MELK

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Y Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Log-Odds: Y Sites / Y Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0	S939	Sugiyama	POTEF A26C1B	VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
O14545	S191	Sugiyama	TRAFD1 FLN29	QIEALDPPMRLPRRPLRAFEsDVFHNRTTNQRNITAQVSIQ
O14639	S452	Sugiyama	ABLIM1 ABLIM KIAA0059 LIMAB1	PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15226	S618	Sugiyama	NKRF ITBA4 NRF	VNKIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQ
O15226	T620	Sugiyama	NKRF ITBA4 NRF	KIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQIA
O15530	T354	SIGNOR\|EPSD	PDPK1 PDK1	GPLKAHPFFESVTWENLHQQtPPKLTAYLPAMSEDDEDCyG
O43707	T445	Sugiyama	ACTN4	HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O43823	S323	Sugiyama	AKAP8 AKAP95	RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852	S69	Sugiyama	CALU	HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60361	Y136	Sugiyama	NME2P1	SLRFKPEELVDYKSCAHDWVyE___________________
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00558	Y161	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04406	Y314	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	tFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsK
P04406	Y320	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE_____
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792	S83	Sugiyama	HSPB1 HSP27 HSP28	IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P05455	S94	Sugiyama	SSB	KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P06733	S27	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733	Y44	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205	Y161	Sugiyama	PGK2 PGKB	KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07339	S37	Sugiyama	CTSD CPSD	PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	T317	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P07900	Y160	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	SAYLVAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPM
P07900	Y309	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900	Y313	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S48	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238	T309	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238	Y155	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	SAYLVAEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPI
P08238	Y301	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238	Y305	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238	Y472	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	sELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEsKE
P08708	Y84	Sugiyama	RPS17 RPS17L	GPVRGISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKE
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P10809	Y243	Sugiyama	HSPD1 HSP60	yIsPyFINtsKGQKCEFQDAyVLLsEKKIssIQsIVPALEI
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11532	S3623	Sugiyama	DMD	EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P13667	T449	Sugiyama	PDIA4 ERP70 ERP72	AATQFWRSKVLEVAKDFPEytFAIADEEDyAGEVKDLGLsE
P13667	Y458	Sugiyama	PDIA4 ERP70 ERP72	VLEVAKDFPEytFAIADEEDyAGEVKDLGLsEsGEDVNAAI
P14314	Y106	Sugiyama	PRKCSH G19P1	yIPSNRVNDGVCDCCDGtDEyNsGVICENtCKEKGRKEREs
P14618	T45	Sugiyama	PKM OIP3 PK2 PK3 PKM2	TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14625	S109	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625	S514	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P18615	S135	Sugiyama	NELFE RD RDBP	sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18669	S14	Sugiyama	PGAM1 PGAMA CDABP0006	_______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P19338	S328	Sugiyama	NCL	NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P20674	T105	Sugiyama	COX5A	EPKIIDAALRACRRLNDFAstVRILEVVKDKAGPHKEIYPY
P22059	S240	Sugiyama	OSBP OSBP1	DLSTCNDLIAKHGTALQRsLsELEsLKLPAESNEKIKQVNE
P22392	Y151	Sugiyama	NME2 NM23B	SLWFKPEELVDyKSCAHDWVyE___________________
P23528	T70	Sugiyama	CFL1 CFL	EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588	S406	EPSD\|PSP	EIF4B	KLQRQLDEPKLERRPRERHPsWRsEEtQERERsRtGsEssQ
P23588	S422	EPSD\|PSP	EIF4B	ERHPsWRsEEtQERERsRtGsEssQtGtstTssRNARRREs
P23588	Y609	Sugiyama	EIF4B	sASKyAALsVDGEDENEGEDyAE__________________
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25205	Y19	Sugiyama	MCM3	__MAGtVVLDDVELREAQRDyLDFLDDEEDQGIyQsKVREL
P25205	Y32	Sugiyama	MCM3	LREAQRDyLDFLDDEEDQGIyQsKVRELIsDNQyRLIVNVN
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T107	Sugiyama	RPL13 BBC1 OK/SW-cl.46	HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26373	T151	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P30305	S169	GPS6\|SIGNOR\|EPSD\|PSP	CDC25B CDC25HU2	FQsMPVRLLGHsPVLRNItNsQAPDGRRKsEAGSGAAssSG
P30305	S219	SIGNOR	CDC25B CDC25HU2	FKMPWKPTHPsSTHALAEWAsRREAFAQRPssAPDLMCLsP
P30305	S321	EPSD	CDC25B CDC25HU2	LEKEEEKDLVMYSKCQRLFRsPsMPCSVIRPILKRLERPQD
P30305	S323	GPS6\|EPSD\|PSP	CDC25B CDC25HU2	KEEEKDLVMYSKCQRLFRsPsMPCSVIRPILKRLERPQDRD
P31327	T45	Sugiyama	CPS1	AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P32119	T142	Sugiyama	PRDX2 NKEFB TDPX1	EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P32969	Y180	Sugiyama	RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9	LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P33527	S915	Sugiyama	ABCC1 MRP MRP1	QMENGMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQ
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35268	Y114	Sugiyama	RPL22	NNLRDWLRVVANSKESYELRyFQINQDEEEEEDED______
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P39019	Y48	Sugiyama	RPS19	LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P42677	S78	Sugiyama	RPS27 MPS1	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013	S651	Sugiyama	MKI67	ISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLGAKQ
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49588	S775	Sugiyama	AARS1 AARS	VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P53999	S118	Sugiyama	SUB1 PC4 RPO2TC1	PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55010	S10	Sugiyama	EIF5	___________MSVNVNRsVsDQFyRyKMPRLIAKVEGKGN
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S239	Sugiyama	ACTB	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709	T297	Sugiyama	ACTB	TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P60709	Y306	Sugiyama	ACTB	DVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPstMK
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62736	S241	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62826	Y146	Sugiyama	RAN ARA24 OK/SW-cl.81	IKDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLAR
P62899	T26	Sugiyama	RPL31	KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P63104	Y149	Sugiyama	YWHAZ	LAEVAAGDDKKGIVDQsQQAyQEAFEIsKKEMQPTHPIRLG
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S239	Sugiyama	ACTG1 ACTG	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261	T297	Sugiyama	ACTG1 ACTG	TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P63261	Y306	Sugiyama	ACTG1 ACTG	DVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPstMK
P63267	S240	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032	S241	Sugiyama	ACTC1 ACTC	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133	S241	Sugiyama	ACTA1 ACTA	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68363	Y432	Sugiyama	TUBA1B	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P68363	Y451	Sugiyama	TUBA1B	DyEEVGVDsVEGEGEEEGEEy____________________
P78345	S253	Sugiyama	RPP38	DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731	S86	Sugiyama	RPL24	EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731	T83	Sugiyama	RPL24	QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00839	Y260	Sugiyama	HNRNPU C1orf199 HNRPU SAFA U21.1	GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q02878	T118	Sugiyama	RPL6 TXREB1	GDKNGGTRVVKLRKMPRyyPtEDVPRKLLSHGKKPFSQHVR
Q02878	Y116	Sugiyama	RPL6 TXREB1	VGGDKNGGTRVVKLRKMPRyyPtEDVPRKLLSHGKKPFSQH
Q06210	T263	Sugiyama	GFPT1 GFAT GFPT	QGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDASA
Q06830	T143	Sugiyama	PRDX1 PAGA PAGB TDPX2	EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q12965	S1002	Sugiyama	MYO1E MYO1C	RSNQKSLyTsMARPPLPRQQstssDRVsQtPEsLDFLKVPD
Q14257	Y39	Sugiyama	RCN2 ERC55	AAGAGKAEELHyPLGERRsDyDREALLGVQEDVDEyVKLGH
Q14257	Y54	Sugiyama	RCN2 ERC55	ERRsDyDREALLGVQEDVDEyVKLGHEEQQKRLQAIIKKID
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568	Y160	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	SAYLVAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERM
Q14680	S171	GPS6\|SIGNOR\|EPSD\|PSP\|Sugiyama	MELK KIAA0175	FGLCAKPKGNKDyHLQtCCGsLAYAAPELIQGKSYLGSEAD
Q14680	S253	GPS6\|EPSD\|PSP	MELK KIAA0175	SPSSILLLQQMLQVDPKKRIsMKNLLNHPWIMQDYNyPVEW
Q14680	S336	GPS6\|EPSD\|PSP	MELK KIAA0175	TYLLLLAKKARGKPVRLRLssFsCGQAsAtPFTDIKSNNWs
Q14680	S343	GPS6\|EPSD\|PSP	MELK KIAA0175	KKARGKPVRLRLssFsCGQAsAtPFTDIKSNNWsLEDVtAs
Q14680	S356	GPS6\|SIGNOR\|EPSD\|PSP\|Sugiyama	MELK KIAA0175	sFsCGQAsAtPFTDIKSNNWsLEDVtAsDKNyVAGLIDYDW
Q14680	S363	Sugiyama	MELK KIAA0175	sAtPFTDIKSNNWsLEDVtAsDKNyVAGLIDYDWCEDDLST
Q14680	S391	GPS6\|SIGNOR\|EPSD\|PSP	MELK KIAA0175	LIDYDWCEDDLSTGAAtPRTsQFTKyWtEsNGVEsKsLtPA
Q14680	S405	EPSD\|PSP	MELK KIAA0175	AAtPRTsQFTKyWtEsNGVEsKsLtPALCRtPANKLKNKEN
Q14680	S407	GPS6\|SIGNOR\|EPSD\|PSP	MELK KIAA0175	tPRTsQFTKyWtEsNGVEsKsLtPALCRtPANKLKNKENVY
Q14680	S431	GPS6\|SIGNOR\|EPSD\|PSP	MELK KIAA0175	ALCRtPANKLKNKENVYtPKsAVKNEEyFMFPEPKtPVNKN
Q14680	S505	GPS6\|SIGNOR\|EPSD\|PSP	MELK KIAA0175	NSTGTDKLMtGVIsPERRCRsVELDLNQAHMEEtPKRKGAK
Q14680	S529	GPS6\|SIGNOR\|EPSD\|PSP	MELK KIAA0175	DLNQAHMEEtPKRKGAKVFGsLERGLDKVItVLTRSKRKGS
Q14680	T167	GPS6\|SIGNOR\|EPSD\|PSP	MELK KIAA0175	KLIDFGLCAKPKGNKDyHLQtCCGsLAYAAPELIQGKSYLG
Q14680	T361	Sugiyama	MELK KIAA0175	QAsAtPFTDIKSNNWsLEDVtAsDKNyVAGLIDYDWCEDDL
Q14680	T387	EPSD\|PSP	MELK KIAA0175	yVAGLIDYDWCEDDLSTGAAtPRTsQFTKyWtEsNGVEsKs
Q14680	T398	GPS6\|SIGNOR\|EPSD\|PSP\|Sugiyama	MELK KIAA0175	EDDLSTGAAtPRTsQFTKyWtEsNGVEsKsLtPALCRtPAN
Q14680	T409	EPSD\|PSP	MELK KIAA0175	RTsQFTKyWtEsNGVEsKsLtPALCRtPANKLKNKENVYtP
Q14680	T494	GPS6\|SIGNOR\|EPSD\|PSP	MELK KIAA0175	CLKEtPIKIPVNSTGTDKLMtGVIsPERRCRsVELDLNQAH
Q14680	T539	GPS6\|SIGNOR\|EPSD\|PSP	MELK KIAA0175	PKRKGAKVFGsLERGLDKVItVLTRSKRKGSARDGPRRLKL
Q14680	T56	GPS6\|EPSD\|PSP	MELK KIAA0175	MVAIKIMDKNTLGSDLPRIKtEIEALKNLRHQHICQLYHVL
Q14680	Y163	EPSD\|PSP	MELK KIAA0175	YHKLKLIDFGLCAKPKGNKDyHLQtCCGsLAYAAPELIQGK
Q14680	Y367	EPSD\|PSP	MELK KIAA0175	FTDIKSNNWsLEDVtAsDKNyVAGLIDYDWCEDDLSTGAAt
Q14680	Y396	Sugiyama	MELK KIAA0175	WCEDDLSTGAAtPRTsQFTKyWtEsNGVEsKsLtPALCRtP
Q14680	Y438	EPSD\|PSP\|Sugiyama	MELK KIAA0175	NKLKNKENVYtPKsAVKNEEyFMFPEPKtPVNKNQHKREIL
Q15172	S472	Sugiyama	PPP2R5A	EELWKKLEELKLKKALEKQNsAyNMHSILSNTSAE______
Q15293	Y278	Sugiyama	RCN1 RCN	LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q15818	S91	Sugiyama	NPTX1	TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP
Q15818	S93	Sugiyama	NPTX1	LSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQPGS
Q15910	S220	SIGNOR\|PSP	EZH2 KMT6	QKDLEDHRDDKESRPPRKFPsDKIFEAISSMFPDKGTAEEL
Q16658	S237	Sugiyama	FSCN1 FAN1 HSN SNL	RsGKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALE
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q562R1	S240	Sugiyama	ACTBL2	VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q5T035	S66	Sugiyama	FAM120A2P C9orf129	LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI
Q5T035	T62	Sugiyama	FAM120A2P C9orf129	yPysLSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyER
Q6GYQ0	S797	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	EtGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDM
Q6PKG0	S627	Sugiyama	LARP1 KIAA0731 LARP	FLFDEEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVt
Q6PKG0	S631	Sugiyama	LARP1 KIAA0731 LARP	EEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVtQtPH
Q6PKG0	Y633	Sugiyama	LARP1 KIAA0731 LARP	MEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVtQtPHyM
Q6S8J3	S939	Sugiyama	POTEE A26C1A POTE2	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36	Y432	Sugiyama	TUBA1A TUBA3	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71U36	Y451	Sugiyama	TUBA1A TUBA3	DyEEVGVDsVEGEGEEEGEEy____________________
Q71UM5	S78	Sugiyama	RPS27L	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q86V81	Y250	Sugiyama	ALYREF ALY BEF THOC4	AGRNSKQQLsAEELDAQLDAyNARMDts_____________
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IWX8	S904	Sugiyama	CHERP DAN26 SCAF6	KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8N8S7	S125	Sugiyama	ENAH MENA	MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NFH8	S631	Sugiyama	REPS2 POB1	AIQTAIRKNKEANAVLARLNsELQQQLKEVHQERIALENQL
Q8WUF5	S102	Sugiyama	PPP1R13L IASPP NKIP1 PPP1R13BL RAI	RGsPRKAATDGADtPFGRsEsAPtLHPysPLsPKGRPssPR
Q96D71	S767	Sugiyama	REPS1	AIQAsIRRNKETNTVLARLNsELQQQLKDVLEERISLEVQL
Q96PK6	S520	Sugiyama	RBM14 SIP	AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q99613	S754	Sugiyama	EIF3C EIF3S8	REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK
Q99618	S94	Sugiyama	CDCA3 C8 GRCC8 TOME1	ARtPMKTSsGDPPsPLVKQLsEVFETEDSKSNLPPEPVLPP
Q99683	T838	GPS6\|EPSD	MAP3K5 ASK1 MAPKKK5 MEKK5	LKISDFGtSKRLAGINPCTEtFTGtLQyMAPEIIDKGPRGY
Q9BQE3	Y432	Sugiyama	TUBA1C TUBA6	GMEEGEFSEAREDMAALEKDyEEVGADsADGEDEGEEy___
Q9BYX7	S239	Sugiyama	POTEKP ACTBL3 FKSG30	VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9H0H5	S257	Sugiyama	RACGAP1 KIAA1478 MGCRACGAP	ETVPYWtRSRRKtGtLQPWNsDstLNSRQLEPRTETDsVGt
Q9H1E3	Y146	Sugiyama	NUCKS1 NUCKS JC7	QEKDsGsDEDFLMEDDDDsDyGSsKKKNKKMVKKSKPERKE
Q9H788	S315	Sugiyama	SH2D4A PPP1R38 SH2A	LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9HAU0	S410	Sugiyama	PLEKHA5 KIAA1686 PEPP2	NRPNTGPLytEADRVIQRtNsMQQLEQWIKIQKGRGHEEET
Q9HD42	S101	Sugiyama	CHMP1A CHMP1 KIAA0047 PCOLN3 PRSM1	TMKGVTKNMAQVTKALDKALsTMDLQKVSSVMDRFEQQVQN
Q9NUU7	T467	Sugiyama	DDX19A DDX19L	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9NZB2	S417	Sugiyama	FAM120A C9orf10 KIAA0183 OSSA	LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI
Q9NZB2	T413	Sugiyama	FAM120A C9orf10 KIAA0183 OSSA	yPysLSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyER
Q9P1Y5	S431	Sugiyama	CAMSAP3 KIAA1543	FGLDSDVDVVMGDPVLLRsVssDsLGPPRPAPARTPtQPPP
Q9UGV2	S331	Sugiyama	NDRG3	QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UMR2	T468	Sugiyama	DDX19B DBP5 DDX19 TDBP	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9Y490	S1535	Sugiyama	TLN1 KIAA1027 TLN	RTTNPTAKRQFVQSAKEVANsTANLVKTIKALDGAFTEENR
Q9Y4G6	S1537	Sugiyama	TLN2 KIAA0320	KTANPVAKRHFVQSAKEVANsTANLVKTIKALDGDFSEDNR

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
HSF1-dependent transactivation	R-HSA-3371571	2.993491e-10	9.524
Cell Cycle	R-HSA-1640170	1.135695e-09	8.945
Cellular response to heat stress	R-HSA-3371556	1.806986e-09	8.743
Mitotic Prometaphase	R-HSA-68877	4.450126e-09	8.352
Attenuation phase	R-HSA-3371568	6.839525e-09	8.165
Axon guidance	R-HSA-422475	9.710734e-09	8.013
Cell Cycle, Mitotic	R-HSA-69278	2.823040e-08	7.549
Nervous system development	R-HSA-9675108	4.777699e-08	7.321
Signal Transduction	R-HSA-162582	1.827207e-07	6.738
NRAGE signals death through JNK	R-HSA-193648	2.791399e-07	6.554
HSF1 activation	R-HSA-3371511	2.942628e-07	6.531
G alpha (12/13) signalling events	R-HSA-416482	6.065793e-07	6.217
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.649124e-06	5.783
M Phase	R-HSA-68886	1.880412e-06	5.726
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	2.472872e-06	5.607
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.496941e-06	5.603
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.523098e-06	5.453
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	5.038595e-06	5.298
Death Receptor Signaling	R-HSA-73887	5.700883e-06	5.244
Mitotic G2-G2/M phases	R-HSA-453274	7.144920e-06	5.146
p75 NTR receptor-mediated signalling	R-HSA-193704	7.696030e-06	5.114
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.004824e-05	4.998
Amplification of signal from the kinetochores	R-HSA-141424	1.004824e-05	4.998
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.220961e-05	4.913
Semaphorin interactions	R-HSA-373755	1.613826e-05	4.792
G2/M Transition	R-HSA-69275	2.028944e-05	4.693
Mitotic Spindle Checkpoint	R-HSA-69618	2.147339e-05	4.668
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.670687e-05	4.573
Cell Cycle Checkpoints	R-HSA-69620	2.727312e-05	4.564
Apoptotic execution phase	R-HSA-75153	3.504126e-05	4.455
Post NMDA receptor activation events	R-HSA-438064	3.602091e-05	4.443
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.360565e-05	4.360
Regulation of TP53 Activity	R-HSA-5633007	5.363451e-05	4.271
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	5.857501e-05	4.232
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	7.965815e-05	4.099
Centrosome maturation	R-HSA-380287	8.767082e-05	4.057
Separation of Sister Chromatids	R-HSA-2467813	9.038089e-05	4.044
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	9.908956e-05	4.004
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.182410e-04	3.927
Mitotic Anaphase	R-HSA-68882	1.340083e-04	3.873
Kinesins	R-HSA-983189	1.403726e-04	3.853
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.491972e-04	3.826
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.556583e-04	3.808
FOXO-mediated transcription	R-HSA-9614085	1.896212e-04	3.722
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.866925e-04	3.729
Neurodegenerative Diseases	R-HSA-8863678	2.319412e-04	3.635
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.319412e-04	3.635
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	4.370995e-04	3.359
Muscle contraction	R-HSA-397014	4.477089e-04	3.349
L1CAM interactions	R-HSA-373760	4.374526e-04	3.359
AURKA Activation by TPX2	R-HSA-8854518	4.646572e-04	3.333
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	4.930914e-04	3.307
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	6.114811e-04	3.214
Loss of Nlp from mitotic centrosomes	R-HSA-380259	6.114811e-04	3.214
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	6.128921e-04	3.213
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	7.195275e-04	3.143
FOXO-mediated transcription of cell death genes	R-HSA-9614657	8.552850e-04	3.068
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	9.508920e-04	3.022
Selective autophagy	R-HSA-9663891	9.785686e-04	3.009
Sema4D in semaphorin signaling	R-HSA-400685	1.003990e-03	2.998
Transcriptional Regulation by TP53	R-HSA-3700989	1.043563e-03	2.981
EPH-Ephrin signaling	R-HSA-2682334	1.008752e-03	2.996
Oncogenic MAPK signaling	R-HSA-6802957	1.098312e-03	2.959
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.136050e-03	2.945
Cellular responses to stress	R-HSA-2262752	1.213812e-03	2.916
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.312407e-03	2.882
Nuclear Receptor transcription pathway	R-HSA-383280	1.610094e-03	2.793
Cellular responses to stimuli	R-HSA-8953897	1.921671e-03	2.716
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.925199e-03	2.716
Recycling pathway of L1	R-HSA-437239	2.022943e-03	2.694
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.167431e-03	2.664
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.590791e-03	2.587
CREB phosphorylation	R-HSA-199920	2.590791e-03	2.587
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.719037e-03	2.566
Intracellular signaling by second messengers	R-HSA-9006925	2.391496e-03	2.621
PKMTs methylate histone lysines	R-HSA-3214841	2.917305e-03	2.535
Resolution of D-Loop Structures	R-HSA-5693537	3.390065e-03	2.470
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.545404e-03	2.450
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.625582e-03	2.441
Interleukin-37 signaling	R-HSA-9008059	3.597566e-03	2.444
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.821395e-03	2.418
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	3.877913e-03	2.411
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	3.877913e-03	2.411
Signaling downstream of RAS mutants	R-HSA-9649948	3.877913e-03	2.411
Signaling by RAS mutants	R-HSA-6802949	3.877913e-03	2.411
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.810660e-03	2.419
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	4.057226e-03	2.392
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.356253e-03	2.361
Ion homeostasis	R-HSA-5578775	4.386247e-03	2.358
Programmed Cell Death	R-HSA-5357801	4.395262e-03	2.357
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	4.765850e-03	2.322
Chromatin modifying enzymes	R-HSA-3247509	4.881399e-03	2.311
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	5.045440e-03	2.297
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	5.045440e-03	2.297
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	5.045440e-03	2.297
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	5.045440e-03	2.297
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	5.137840e-03	2.289
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	5.381024e-03	2.269
ChREBP activates metabolic gene expression	R-HSA-163765	5.644430e-03	2.248
Aggrephagy	R-HSA-9646399	5.679500e-03	2.246
RNA Polymerase II Transcription	R-HSA-73857	5.732600e-03	2.242
Apoptosis	R-HSA-109581	6.236948e-03	2.205
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.277925e-03	2.202
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	6.345491e-03	2.198
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	6.983789e-03	2.156
Membrane Trafficking	R-HSA-199991	6.950839e-03	2.158
Impaired BRCA2 binding to RAD51	R-HSA-9709570	7.416238e-03	2.130
Mitotic Telophase/Cytokinesis	R-HSA-68884	8.069499e-03	2.093
Activation of RAC1	R-HSA-428540	8.069499e-03	2.093
Chaperone Mediated Autophagy	R-HSA-9613829	8.663415e-03	2.062
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	8.663415e-03	2.062
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	8.399064e-03	2.076
Signaling by RAF1 mutants	R-HSA-9656223	8.119868e-03	2.090
Gene expression (Transcription)	R-HSA-74160	8.702918e-03	2.060
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	8.399064e-03	2.076
Signaling by ROBO receptors	R-HSA-376176	8.292023e-03	2.081
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	9.050795e-03	2.043
Chromatin organization	R-HSA-4839726	9.530807e-03	2.021
Cardiac conduction	R-HSA-5576891	9.630043e-03	2.016
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.005091e-02	1.998
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.061409e-02	1.974
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	1.005070e-02	1.998
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	1.005070e-02	1.998
mRNA 3'-end processing	R-HSA-72187	1.035357e-02	1.985
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.050043e-02	1.979
Golgi-to-ER retrograde transport	R-HSA-8856688	1.055573e-02	1.977
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.005091e-02	1.998
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.071099e-02	1.970
Transcriptional Regulation by E2F6	R-HSA-8953750	1.077979e-02	1.967
Germ layer formation at gastrulation	R-HSA-9754189	1.117614e-02	1.952
Rap1 signalling	R-HSA-392517	1.117614e-02	1.952
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.118644e-02	1.951
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.118644e-02	1.951
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.172443e-02	1.931
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.203676e-02	1.919
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	1.204688e-02	1.919
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.315714e-02	1.881
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.315714e-02	1.881
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.315714e-02	1.881
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.315714e-02	1.881
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.324655e-02	1.878
Diseases of mitotic cell cycle	R-HSA-9675126	1.341294e-02	1.872
G2/M DNA damage checkpoint	R-HSA-69473	1.368305e-02	1.864
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	1.437264e-02	1.842
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.489610e-02	1.827
Cytokine Signaling in Immune system	R-HSA-1280215	1.494760e-02	1.825
Generic Transcription Pathway	R-HSA-212436	1.497052e-02	1.825
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.509396e-02	1.821
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.509396e-02	1.821
DAG and IP3 signaling	R-HSA-1489509	1.545658e-02	1.811
Signaling by Interleukins	R-HSA-449147	1.572097e-02	1.804
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.778413e-02	1.750
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.694450e-02	1.771
Cilium Assembly	R-HSA-5617833	1.660164e-02	1.780
Diseases of DNA repair	R-HSA-9675135	1.791247e-02	1.747
RUNX3 regulates WNT signaling	R-HSA-8951430	1.809187e-02	1.743
DNA Double-Strand Break Repair	R-HSA-5693532	1.828424e-02	1.738
Specification of primordial germ cells	R-HSA-9827857	1.904913e-02	1.720
Striated Muscle Contraction	R-HSA-390522	1.910464e-02	1.719
Signaling by NTRKs	R-HSA-166520	1.911591e-02	1.719
PIP3 activates AKT signaling	R-HSA-1257604	1.918344e-02	1.717
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.984263e-02	1.702
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.993988e-02	1.700
HDMs demethylate histones	R-HSA-3214842	1.993988e-02	1.700
Long-term potentiation	R-HSA-9620244	1.993988e-02	1.700
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.148865e-02	1.668
RAF activation	R-HSA-5673000	2.254855e-02	1.647
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.093320e-02	1.679
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.172933e-02	1.663
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.187854e-02	1.660
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.230496e-02	1.652
Nuclear Envelope Breakdown	R-HSA-2980766	2.064928e-02	1.685
NrCAM interactions	R-HSA-447038	2.172933e-02	1.663
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.198780e-02	1.658
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.266701e-02	1.645
Diseases of programmed cell death	R-HSA-9645723	2.266740e-02	1.645
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.272079e-02	1.644
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.272079e-02	1.644
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.272079e-02	1.644
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.272079e-02	1.644
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.272079e-02	1.644
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.272079e-02	1.644
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.272079e-02	1.644
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.272079e-02	1.644
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.272079e-02	1.644
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.272079e-02	1.644
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.272079e-02	1.644
TRP channels	R-HSA-3295583	2.408645e-02	1.618
Trafficking of AMPA receptors	R-HSA-399719	2.551861e-02	1.593
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.564840e-02	1.591
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.587459e-02	1.587
Rab regulation of trafficking	R-HSA-9007101	2.598002e-02	1.585
EPHB-mediated forward signaling	R-HSA-3928662	2.712957e-02	1.567
The NLRP3 inflammasome	R-HSA-844456	2.971557e-02	1.527
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.800567e-02	1.553
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.992983e-02	1.524
Calmodulin induced events	R-HSA-111933	3.077642e-02	1.512
CaM pathway	R-HSA-111997	3.077642e-02	1.512
MyD88-independent TLR4 cascade	R-HSA-166166	3.082815e-02	1.511
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.082815e-02	1.511
mRNA Splicing - Major Pathway	R-HSA-72163	3.180960e-02	1.497
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.219415e-02	1.492
Prolonged ERK activation events	R-HSA-169893	3.245776e-02	1.489
MAPK family signaling cascades	R-HSA-5683057	3.299895e-02	1.481
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	3.306848e-02	1.481
RNA Polymerase II Transcription Termination	R-HSA-73856	3.342711e-02	1.476
Formation of editosomes by ADAR proteins	R-HSA-77042	3.650116e-02	1.438
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	3.650116e-02	1.438
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	3.650116e-02	1.438
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.552132e-02	1.450
ARMS-mediated activation	R-HSA-170984	3.552132e-02	1.450
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	3.634510e-02	1.440
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	3.878974e-02	1.411
Integrin signaling	R-HSA-354192	3.517169e-02	1.454
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.517169e-02	1.454
Formation of RNA Pol II elongation complex	R-HSA-112382	3.933613e-02	1.405
Formation of definitive endoderm	R-HSA-9823730	3.634510e-02	1.440
Neurexins and neuroligins	R-HSA-6794361	3.933613e-02	1.405
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	3.504124e-02	1.455
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.517169e-02	1.454
FGFR1 mutant receptor activation	R-HSA-1839124	3.517169e-02	1.454
Organelle biogenesis and maintenance	R-HSA-1852241	3.796822e-02	1.421
Neuronal System	R-HSA-112316	3.461651e-02	1.461
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.517169e-02	1.454
Axonal growth stimulation	R-HSA-209563	3.984498e-02	1.400
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	3.984498e-02	1.400
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	4.037818e-02	1.394
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	4.085402e-02	1.389
MHC class II antigen presentation	R-HSA-2132295	4.189623e-02	1.378
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	4.270873e-02	1.369
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.297090e-02	1.367
Homology Directed Repair	R-HSA-5693538	4.396918e-02	1.357
RNA Polymerase II Transcription Elongation	R-HSA-75955	4.418770e-02	1.355
TBC/RABGAPs	R-HSA-8854214	4.620486e-02	1.335
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.685879e-02	1.329
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.685879e-02	1.329
MET activates RAP1 and RAC1	R-HSA-8875555	4.712206e-02	1.327
Glycolysis	R-HSA-70171	4.924904e-02	1.308
Autophagy	R-HSA-9612973	5.041682e-02	1.297
Signaling by VEGF	R-HSA-194138	5.215587e-02	1.283
Netrin-1 signaling	R-HSA-373752	5.222342e-02	1.282
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.330722e-02	1.273
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	5.413929e-02	1.266
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	5.432325e-02	1.265
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	6.187868e-02	1.208
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	6.187868e-02	1.208
Interaction between L1 and Ankyrins	R-HSA-445095	6.269702e-02	1.203
EPHA-mediated growth cone collapse	R-HSA-3928663	6.269702e-02	1.203
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	6.247889e-02	1.204
mRNA Splicing	R-HSA-72172	6.038415e-02	1.219
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.960292e-02	1.225
G0 and Early G1	R-HSA-1538133	6.247889e-02	1.204
Polo-like kinase mediated events	R-HSA-156711	5.974028e-02	1.224
Ephrin signaling	R-HSA-3928664	5.974028e-02	1.224
Regulation of TP53 Degradation	R-HSA-6804757	6.161881e-02	1.210
Dopamine receptors	R-HSA-390651	6.187868e-02	1.208
Cellular Senescence	R-HSA-2559583	5.583677e-02	1.253
RAF/MAP kinase cascade	R-HSA-5673001	6.367548e-02	1.196
Depolymerization of the Nuclear Lamina	R-HSA-4419969	5.974028e-02	1.224
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	5.974028e-02	1.224
FLT3 Signaling	R-HSA-9607240	6.032980e-02	1.219
Cohesin Loading onto Chromatin	R-HSA-2470946	6.438574e-02	1.191
Regulation of PTEN localization	R-HSA-8948747	6.438574e-02	1.191
Regulation of TNFR1 signaling	R-HSA-5357905	6.581741e-02	1.182
MAPK1/MAPK3 signaling	R-HSA-5684996	6.640599e-02	1.178
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.780129e-02	1.169
p75NTR signals via NF-kB	R-HSA-193639	6.780129e-02	1.169
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	6.780304e-02	1.169
Signaling by FGFR1 in disease	R-HSA-5655302	6.794042e-02	1.168
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	6.984127e-02	1.156
ESR-mediated signaling	R-HSA-8939211	7.083703e-02	1.150
STING mediated induction of host immune responses	R-HSA-1834941	7.123884e-02	1.147
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	7.138521e-02	1.146
Regulation of necroptotic cell death	R-HSA-5675482	7.138521e-02	1.146
Regulation of MECP2 expression and activity	R-HSA-9022692	7.138521e-02	1.146
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	7.138521e-02	1.146
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	7.138521e-02	1.146
Activation of AMPK downstream of NMDARs	R-HSA-9619483	7.237052e-02	1.140
Breakdown of the nuclear lamina	R-HSA-352238	7.460002e-02	1.127
Interactions of Tat with host cellular proteins	R-HSA-176034	7.460002e-02	1.127
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	7.460002e-02	1.127
SMAC (DIABLO) binds to IAPs	R-HSA-111463	8.839293e-02	1.054
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	8.839293e-02	1.054
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	8.839293e-02	1.054
Type I hemidesmosome assembly	R-HSA-446107	8.427723e-02	1.074
RSK activation	R-HSA-444257	8.427723e-02	1.074
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	8.427723e-02	1.074
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.631184e-02	1.117
Signaling by GSK3beta mutants	R-HSA-5339716	7.631184e-02	1.117
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	8.187083e-02	1.087
TRAF6 mediated NF-kB activation	R-HSA-933542	8.404365e-02	1.075
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	8.291785e-02	1.081
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	8.228357e-02	1.085
snRNP Assembly	R-HSA-191859	8.228357e-02	1.085
Metabolism of non-coding RNA	R-HSA-194441	8.228357e-02	1.085
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	7.483568e-02	1.126
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	7.873515e-02	1.104
Estrogen-dependent gene expression	R-HSA-9018519	8.363600e-02	1.078
DARPP-32 events	R-HSA-180024	8.291785e-02	1.081
Cyclin E associated events during G1/S transition	R-HSA-69202	8.170409e-02	1.088
Effects of PIP2 hydrolysis	R-HSA-114508	8.105238e-02	1.091
Macroautophagy	R-HSA-1632852	7.936082e-02	1.100
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.396912e-02	1.131
Potassium Channels	R-HSA-1296071	8.629602e-02	1.064
Transcriptional regulation by RUNX1	R-HSA-8878171	7.443620e-02	1.128
Ca-dependent events	R-HSA-111996	7.614976e-02	1.118
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	8.170409e-02	1.088
ISG15 antiviral mechanism	R-HSA-1169408	7.774155e-02	1.109
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	7.848761e-02	1.105
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	8.427723e-02	1.074
Eukaryotic Translation Elongation	R-HSA-156842	9.102788e-02	1.041
p75NTR recruits signalling complexes	R-HSA-209543	9.385361e-02	1.028
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	9.385361e-02	1.028
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	9.385361e-02	1.028
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	9.385361e-02	1.028
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	9.385361e-02	1.028
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	9.385361e-02	1.028
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	9.385361e-02	1.028
Developmental Lineages of the Mammary Gland	R-HSA-9924644	9.663994e-02	1.015
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	9.663994e-02	1.015
PLC beta mediated events	R-HSA-112043	9.861670e-02	1.006
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.038312e-01	0.984
TNF signaling	R-HSA-75893	1.038312e-01	0.984
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.044265e-01	0.981
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.059298e-01	0.975
mRNA Editing: A to I Conversion	R-HSA-75064	1.206228e-01	0.919
Regulation of TP53 Expression	R-HSA-6804754	1.206228e-01	0.919
C6 deamination of adenosine	R-HSA-75102	1.206228e-01	0.919
Potassium transport channels	R-HSA-1296067	1.206228e-01	0.919
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	1.188093e-01	0.925
CLEC7A/inflammasome pathway	R-HSA-5660668	1.188093e-01	0.925
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	1.188093e-01	0.925
IkBA variant leads to EDA-ID	R-HSA-5603029	1.188093e-01	0.925
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.067936e-01	0.971
Regulated proteolysis of p75NTR	R-HSA-193692	1.067936e-01	0.971
Lipophagy	R-HSA-9613354	1.067936e-01	0.971
ALK mutants bind TKIs	R-HSA-9700645	1.067936e-01	0.971
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.132626e-01	0.946
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.144580e-01	0.941
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.247672e-01	0.904
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.094864e-01	0.961
Voltage gated Potassium channels	R-HSA-1296072	1.273362e-01	0.895
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.227211e-01	0.911
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.227211e-01	0.911
Extra-nuclear estrogen signaling	R-HSA-9009391	1.211668e-01	0.917
Apoptosis induced DNA fragmentation	R-HSA-140342	1.317083e-01	0.880
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.328665e-01	0.877
G1/S DNA Damage Checkpoints	R-HSA-69615	1.168172e-01	0.932
Processing of DNA double-strand break ends	R-HSA-5693607	1.240563e-01	0.906
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.197836e-01	0.922
Frs2-mediated activation	R-HSA-170968	1.132626e-01	0.946
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.067936e-01	0.971
MAP2K and MAPK activation	R-HSA-5674135	1.210851e-01	0.917
Signaling by Hippo	R-HSA-2028269	1.144580e-01	0.941
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.240499e-01	0.906
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	1.067936e-01	0.971
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	1.132626e-01	0.946
Synaptic adhesion-like molecules	R-HSA-8849932	1.328665e-01	0.877
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	1.102017e-01	0.958
Platelet activation, signaling and aggregation	R-HSA-76002	1.222587e-01	0.913
Protein-protein interactions at synapses	R-HSA-6794362	1.091535e-01	0.962
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.328665e-01	0.877
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.172523e-01	0.931
Interleukin-1 family signaling	R-HSA-446652	1.117166e-01	0.952
Regulated Necrosis	R-HSA-5218859	1.105743e-01	0.956
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	1.317083e-01	0.880
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.144580e-01	0.941
Glucose metabolism	R-HSA-70326	1.306185e-01	0.884
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.074839e-01	0.969
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.317083e-01	0.880
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	1.293029e-01	0.888
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.297289e-01	0.887
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.067936e-01	0.971
Signaling by ALK in cancer	R-HSA-9700206	1.297289e-01	0.887
Transport of connexons to the plasma membrane	R-HSA-190872	1.328665e-01	0.877
MTOR signalling	R-HSA-165159	1.333428e-01	0.875
CRMPs in Sema3A signaling	R-HSA-399956	1.344241e-01	0.872
cGMP effects	R-HSA-418457	1.344241e-01	0.872
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	1.344241e-01	0.872
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.368676e-01	0.864
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.377093e-01	0.861
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.384698e-01	0.859
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.384698e-01	0.859
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.384698e-01	0.859
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.384698e-01	0.859
Phase 0 - rapid depolarisation	R-HSA-5576892	1.402841e-01	0.853
Inflammasomes	R-HSA-622312	1.402841e-01	0.853
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.407637e-01	0.852
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.407637e-01	0.852
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	1.716464e-01	0.765
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.716464e-01	0.765
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.887090e-01	0.724
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.887090e-01	0.724
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.887090e-01	0.724
TRIF-mediated programmed cell death	R-HSA-2562578	1.887090e-01	0.724
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.587510e-01	0.799
Signaling by APC mutants	R-HSA-4839744	1.587510e-01	0.799
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.587510e-01	0.799
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.587510e-01	0.799
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.587510e-01	0.799
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.876232e-01	0.727
Beta-catenin phosphorylation cascade	R-HSA-196299	1.571964e-01	0.804
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.814170e-01	0.741
Phase 4 - resting membrane potential	R-HSA-5576886	1.814170e-01	0.741
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.814170e-01	0.741
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.466815e-01	0.834
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.485666e-01	0.828
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.740009e-01	0.759
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.740009e-01	0.759
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.548961e-01	0.810
HIV Transcription Elongation	R-HSA-167169	1.697056e-01	0.770
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.697056e-01	0.770
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.697056e-01	0.770
Formation of a pool of free 40S subunits	R-HSA-72689	1.732116e-01	0.761
DNA Double Strand Break Response	R-HSA-5693606	1.587179e-01	0.799
HATs acetylate histones	R-HSA-3214847	1.542081e-01	0.812
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.633447e-01	0.787
Regulation of NF-kappa B signaling	R-HSA-9758274	1.814170e-01	0.741
Signaling by ERBB2	R-HSA-1227986	1.450978e-01	0.838
Cytochrome c-mediated apoptotic response	R-HSA-111461	1.876232e-01	0.727
Peptide chain elongation	R-HSA-156902	1.436606e-01	0.843
Opioid Signalling	R-HSA-111885	1.456805e-01	0.837
G2/M Checkpoints	R-HSA-69481	1.705620e-01	0.768
Signalling to ERKs	R-HSA-187687	1.804498e-01	0.744
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.525805e-01	0.817
Mitotic Prophase	R-HSA-68875	1.542514e-01	0.812
Sodium/Calcium exchangers	R-HSA-425561	1.876232e-01	0.727
NF-kB is activated and signals survival	R-HSA-209560	1.876232e-01	0.727
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	1.571964e-01	0.804
Platelet calcium homeostasis	R-HSA-418360	1.567116e-01	0.805
Interactions of Rev with host cellular proteins	R-HSA-177243	1.697056e-01	0.770
G-protein mediated events	R-HSA-112040	1.587179e-01	0.799
Nuclear import of Rev protein	R-HSA-180746	1.641395e-01	0.785
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.539614e-01	0.813
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.452174e-01	0.838
Response of endothelial cells to shear stress	R-HSA-9860931	1.456805e-01	0.837
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.452174e-01	0.838
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.452174e-01	0.838
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.804498e-01	0.744
Reduction of cytosolic Ca++ levels	R-HSA-418359	1.876232e-01	0.727
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.735024e-01	0.761
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.470251e-01	0.833
DNA Repair	R-HSA-73894	1.455068e-01	0.837
FasL/ CD95L signaling	R-HSA-75157	1.716464e-01	0.765
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.885967e-01	0.724
Transmission across Chemical Synapses	R-HSA-112315	1.823252e-01	0.739
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.664274e-01	0.779
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.876232e-01	0.727
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.571964e-01	0.804
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.567116e-01	0.805
Phase 3 - rapid repolarisation	R-HSA-5576890	1.887090e-01	0.724
Signaling by AMER1 mutants	R-HSA-4839748	1.876232e-01	0.727
Signaling by AXIN mutants	R-HSA-4839735	1.876232e-01	0.727
Cell-extracellular matrix interactions	R-HSA-446353	1.571964e-01	0.804
Transcriptional Regulation by VENTX	R-HSA-8853884	1.851602e-01	0.732
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.650985e-01	0.782
LGI-ADAM interactions	R-HSA-5682910	1.587510e-01	0.799
RAB geranylgeranylation	R-HSA-8873719	1.450978e-01	0.838
PI Metabolism	R-HSA-1483255	1.829701e-01	0.738
PKR-mediated signaling	R-HSA-9833482	1.723410e-01	0.764
HIV Life Cycle	R-HSA-162587	1.898525e-01	0.722
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.920964e-01	0.716
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.920964e-01	0.716
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.922945e-01	0.716
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.922945e-01	0.716
Stimuli-sensing channels	R-HSA-2672351	1.922945e-01	0.716
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.928146e-01	0.715
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.938527e-01	0.713
ERK/MAPK targets	R-HSA-198753	1.955216e-01	0.709
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.577726e-01	0.589
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.577726e-01	0.589
Diseases of Telomere Maintenance	R-HSA-9673013	2.577726e-01	0.589
Defective SLC2A10 causes arterial tortuosity syndrome (ATS)	R-HSA-5619068	2.577726e-01	0.589
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	2.577726e-01	0.589
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.577726e-01	0.589
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.577726e-01	0.589
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.577726e-01	0.589
TICAM1 deficiency - HSE	R-HSA-5602566	2.577726e-01	0.589
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.577726e-01	0.589
Defective SLC26A4 causes Pendred syndrome (PDS)	R-HSA-5619046	2.577726e-01	0.589
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	2.577726e-01	0.589
Defective Mismatch Repair Associated With MSH3	R-HSA-5632927	2.577726e-01	0.589
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.577726e-01	0.589
HCN channels	R-HSA-1296061	2.254047e-01	0.647
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.254047e-01	0.647
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.254047e-01	0.647
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.254047e-01	0.647
NFG and proNGF binds to p75NTR	R-HSA-205017	3.605605e-01	0.443
Mitochondrial transcription initiation	R-HSA-163282	3.605605e-01	0.443
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	3.605605e-01	0.443
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.605605e-01	0.443
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.605605e-01	0.443
Signaling by TCF7L2 mutants	R-HSA-5339700	3.605605e-01	0.443
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.605605e-01	0.443
Defective MMADHC causes MMAHCD	R-HSA-3359473	3.605605e-01	0.443
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.605605e-01	0.443
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.605605e-01	0.443
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.605605e-01	0.443
TRAF3 deficiency - HSE	R-HSA-5602571	3.605605e-01	0.443
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.605605e-01	0.443
Intestinal infectious diseases	R-HSA-8942233	3.605605e-01	0.443
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.605605e-01	0.443
Defective SLC12A3 causes Gitelman syndrome (GS)	R-HSA-5619087	3.605605e-01	0.443
MyD88 deficiency (TLR5)	R-HSA-5602680	3.605605e-01	0.443
IKBKB deficiency causes SCID	R-HSA-5602636	3.605605e-01	0.443
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.605605e-01	0.443
XAV939 stabilizes AXIN	R-HSA-5545619	3.605605e-01	0.443
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.605605e-01	0.443
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.605605e-01	0.443
IRS activation	R-HSA-74713	2.801629e-01	0.553
NOSIP mediated eNOS trafficking	R-HSA-203754	2.801629e-01	0.553
G2 Phase	R-HSA-68911	2.801629e-01	0.553
ROBO receptors bind AKAP5	R-HSA-9010642	2.268517e-01	0.644
Axonal growth inhibition (RHOA activation)	R-HSA-193634	2.268517e-01	0.644
Regulation by c-FLIP	R-HSA-3371378	2.268517e-01	0.644
Dimerization of procaspase-8	R-HSA-69416	2.268517e-01	0.644
IRAK1 recruits IKK complex	R-HSA-937039	2.180110e-01	0.662
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	2.180110e-01	0.662
p75NTR regulates axonogenesis	R-HSA-193697	2.662767e-01	0.575
WNT mediated activation of DVL	R-HSA-201688	2.662767e-01	0.575
Inactivation of CDC42 and RAC1	R-HSA-428543	2.662767e-01	0.575
CASP8 activity is inhibited	R-HSA-5218900	2.662767e-01	0.575
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	3.346141e-01	0.475
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.346141e-01	0.475
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	3.346141e-01	0.475
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.346141e-01	0.475
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.346141e-01	0.475
PTK6 Regulates Cell Cycle	R-HSA-8849470	3.346141e-01	0.475
Signaling by MAPK mutants	R-HSA-9652817	3.346141e-01	0.475
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.491189e-01	0.348
TWIK related potassium channel (TREK)	R-HSA-1299503	4.491189e-01	0.348
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.491189e-01	0.348
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.491189e-01	0.348
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.069081e-01	0.684
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.069081e-01	0.684
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.069081e-01	0.684
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.495960e-01	0.603
Formation of axial mesoderm	R-HSA-9796292	2.495960e-01	0.603
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.064128e-01	0.514
PI3K/AKT activation	R-HSA-198203	3.064128e-01	0.514
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.064128e-01	0.514
Folding of actin by CCT/TriC	R-HSA-390450	3.064128e-01	0.514
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	3.064128e-01	0.514
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	3.064128e-01	0.514
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.877934e-01	0.411
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	3.877934e-01	0.411
STAT5 Activation	R-HSA-9645135	3.877934e-01	0.411
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	3.877934e-01	0.411
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.877934e-01	0.411
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.609451e-01	0.583
RHOBTB3 ATPase cycle	R-HSA-9706019	3.467508e-01	0.460
DCC mediated attractive signaling	R-HSA-418885	3.151164e-01	0.502
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	3.151164e-01	0.502
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.151164e-01	0.502
Signaling by FGFR2 IIIa TM	R-HSA-8851708	2.891038e-01	0.539
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	2.304534e-01	0.637
IPs transport between nucleus and cytosol	R-HSA-1855170	2.304534e-01	0.637
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.178559e-01	0.662
Late endosomal microautophagy	R-HSA-9615710	2.699674e-01	0.569
Co-inhibition by CTLA4	R-HSA-389513	3.177669e-01	0.498
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	3.484664e-01	0.458
Phosphorylation of the APC/C	R-HSA-176412	3.484664e-01	0.458
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	3.868474e-01	0.412
Condensation of Prometaphase Chromosomes	R-HSA-2514853	3.868474e-01	0.412
Activated NTRK2 signals through CDK5	R-HSA-9032845	4.390094e-01	0.358
Netrin mediated repulsion signals	R-HSA-418886	4.390094e-01	0.358
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	4.390094e-01	0.358
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	4.390094e-01	0.358
Disinhibition of SNARE formation	R-HSA-114516	4.390094e-01	0.358
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.390094e-01	0.358
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	4.390094e-01	0.358
SOS-mediated signalling	R-HSA-112412	4.390094e-01	0.358
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	4.390094e-01	0.358
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	5.254169e-01	0.279
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	5.254169e-01	0.279
Defective MMACHC causes MAHCC	R-HSA-3359474	5.254169e-01	0.279
Invadopodia formation	R-HSA-8941237	5.254169e-01	0.279
Defective GCLC causes HAGGSD	R-HSA-5578999	5.254169e-01	0.279
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.254169e-01	0.279
Defective ABCA1 causes TGD	R-HSA-5682113	5.254169e-01	0.279
MET activates PTPN11	R-HSA-8865999	5.254169e-01	0.279
Defective HPRT1 disrupts guanine and hypoxanthine salvage	R-HSA-9734281	5.254169e-01	0.279
Classical Kir channels	R-HSA-1296053	5.254169e-01	0.279
IRAK4 deficiency (TLR5)	R-HSA-5603037	5.254169e-01	0.279
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.254169e-01	0.279
Defective CYP1B1 causes Glaucoma	R-HSA-5579000	5.254169e-01	0.279
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.923433e-01	0.534
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.707215e-01	0.567
SHC-related events triggered by IGF1R	R-HSA-2428933	4.263255e-01	0.370
G1/S-Specific Transcription	R-HSA-69205	3.138324e-01	0.503
Transcription of the HIV genome	R-HSA-167172	2.494666e-01	0.603
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.696988e-01	0.432
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	3.696988e-01	0.432
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	3.696988e-01	0.432
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	4.150366e-01	0.382
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	4.150366e-01	0.382
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	4.877860e-01	0.312
FGFR1b ligand binding and activation	R-HSA-190370	4.877860e-01	0.312
Signaling by MRAS-complex mutants	R-HSA-9660537	4.877860e-01	0.312
Activation of RAS in B cells	R-HSA-1169092	4.877860e-01	0.312
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.877860e-01	0.312
Meiotic synapsis	R-HSA-1221632	3.047053e-01	0.516
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.425171e-01	0.615
Negative regulation of FGFR3 signaling	R-HSA-5654732	3.958728e-01	0.402
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.958728e-01	0.402
HIV elongation arrest and recovery	R-HSA-167287	3.958728e-01	0.402
Formation of the Early Elongation Complex	R-HSA-113418	3.958728e-01	0.402
Pausing and recovery of HIV elongation	R-HSA-167290	3.958728e-01	0.402
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.648710e-01	0.333
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.875253e-01	0.412
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.797896e-01	0.420
PKA activation in glucagon signalling	R-HSA-164378	4.478059e-01	0.349
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	4.339008e-01	0.363
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	3.079014e-01	0.512
Negative regulation of FGFR4 signaling	R-HSA-5654733	4.219970e-01	0.375
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.479620e-01	0.349
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.479620e-01	0.349
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.625081e-01	0.335
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	4.625081e-01	0.335
Thromboxane signalling through TP receptor	R-HSA-428930	4.625081e-01	0.335
IKK complex recruitment mediated by RIP1	R-HSA-937041	4.799739e-01	0.319
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.799739e-01	0.319
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	5.022295e-01	0.299
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	5.338166e-01	0.273
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	5.338166e-01	0.273
NADE modulates death signalling	R-HSA-205025	5.911512e-01	0.228
TNFR1-mediated ceramide production	R-HSA-5626978	5.911512e-01	0.228
ATP sensitive Potassium channels	R-HSA-1296025	5.911512e-01	0.228
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	5.911512e-01	0.228
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.911512e-01	0.228
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	5.911512e-01	0.228
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	5.113800e-01	0.291
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	4.129530e-01	0.384
Viral mRNA Translation	R-HSA-192823	4.350706e-01	0.361
Spry regulation of FGF signaling	R-HSA-1295596	5.382010e-01	0.269
Erythropoietin activates RAS	R-HSA-9027284	5.382010e-01	0.269
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.382010e-01	0.269
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.382010e-01	0.269
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.382010e-01	0.269
SHC-mediated cascade:FGFR3	R-HSA-5654704	5.418891e-01	0.266
Pexophagy	R-HSA-9664873	5.769263e-01	0.239
2-LTR circle formation	R-HSA-164843	5.769263e-01	0.239
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	4.627170e-01	0.335
Activation of NF-kappaB in B cells	R-HSA-1169091	5.170264e-01	0.286
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.452306e-01	0.263
Cristae formation	R-HSA-8949613	5.452306e-01	0.263
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	5.330848e-01	0.273
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	5.330848e-01	0.273
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	5.330848e-01	0.273
Nucleosome assembly	R-HSA-774815	5.330848e-01	0.273
Neutrophil degranulation	R-HSA-6798695	4.800761e-01	0.319
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.483297e-01	0.261
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	5.512384e-01	0.259
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.713899e-01	0.243
SHC-mediated cascade:FGFR4	R-HSA-5654719	5.713899e-01	0.243
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	5.566070e-01	0.254
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.526484e-01	0.258
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	5.714440e-01	0.243
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.721506e-01	0.242
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	5.721506e-01	0.242
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.880923e-01	0.540
Downstream signaling of activated FGFR3	R-HSA-5654708	4.219970e-01	0.375
Downstream signaling of activated FGFR4	R-HSA-5654716	4.479620e-01	0.349
EGFR downregulation	R-HSA-182971	4.736663e-01	0.325
Eukaryotic Translation Initiation	R-HSA-72613	2.322130e-01	0.634
G1/S Transition	R-HSA-69206	4.306169e-01	0.366
Chaperonin-mediated protein folding	R-HSA-390466	4.622573e-01	0.335
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.507867e-01	0.601
Cap-dependent Translation Initiation	R-HSA-72737	2.322130e-01	0.634
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	2.012236e-01	0.696
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.038410e-01	0.691
IGF1R signaling cascade	R-HSA-2428924	2.819471e-01	0.550
Mismatch Repair	R-HSA-5358508	4.478059e-01	0.349
Specification of the neural plate border	R-HSA-9834899	2.891038e-01	0.539
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.792473e-01	0.554
Negative regulation of FGFR1 signaling	R-HSA-5654726	5.239298e-01	0.281
Signaling by FGFR3	R-HSA-5654741	5.330848e-01	0.273
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.049760e-01	0.393
Signaling by FGFR4	R-HSA-5654743	4.902521e-01	0.310
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.279652e-01	0.484
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.648710e-01	0.333
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.826751e-01	0.316
IRS-related events triggered by IGF1R	R-HSA-2428928	5.773699e-01	0.239
Mitophagy	R-HSA-5205647	4.114888e-01	0.386
Developmental Cell Lineages	R-HSA-9734767	5.321023e-01	0.274
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.435919e-01	0.464
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.507867e-01	0.601
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.150366e-01	0.382
VxPx cargo-targeting to cilium	R-HSA-5620916	5.113800e-01	0.291
Telomere Extension By Telomerase	R-HSA-171319	5.714440e-01	0.243
Epigenetic regulation of gene expression	R-HSA-212165	5.822364e-01	0.235
mRNA Editing	R-HSA-75072	2.662767e-01	0.575
Transcriptional regulation of testis differentiation	R-HSA-9690406	2.069081e-01	0.684
CD28 dependent PI3K/Akt signaling	R-HSA-389357	3.696988e-01	0.432
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	4.150366e-01	0.382
Cyclin D associated events in G1	R-HSA-69231	2.526519e-01	0.597
G1 Phase	R-HSA-69236	2.526519e-01	0.597
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.452548e-01	0.462
Meiosis	R-HSA-1500620	2.316271e-01	0.635
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.726345e-01	0.242
G-protein beta:gamma signalling	R-HSA-397795	3.635868e-01	0.439
NGF-stimulated transcription	R-HSA-9031628	2.195961e-01	0.658
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	3.463011e-01	0.461
p53-Dependent G1 DNA Damage Response	R-HSA-69563	3.463011e-01	0.461
Signal attenuation	R-HSA-74749	3.064128e-01	0.514
PKA-mediated phosphorylation of CREB	R-HSA-111931	3.467492e-01	0.460
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.405664e-01	0.619
PI-3K cascade:FGFR3	R-HSA-5654710	4.799739e-01	0.319
PI-3K cascade:FGFR4	R-HSA-5654720	5.113800e-01	0.291
Golgi Associated Vesicle Biogenesis	R-HSA-432722	5.566070e-01	0.254
Protein folding	R-HSA-391251	5.552905e-01	0.255
TRAF6 mediated IRF7 activation	R-HSA-933541	3.356213e-01	0.474
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	3.215816e-01	0.493
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.979662e-01	0.526
Regulation of the apoptosome activity	R-HSA-9627069	3.064128e-01	0.514
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	2.595271e-01	0.586
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.022295e-01	0.299
PI3K Cascade	R-HSA-109704	4.968113e-01	0.304
EGFR Transactivation by Gastrin	R-HSA-2179392	5.769263e-01	0.239
Interleukin-1 signaling	R-HSA-9020702	5.026516e-01	0.299
Glycogen breakdown (glycogenolysis)	R-HSA-70221	3.176751e-01	0.498
TCF dependent signaling in response to WNT	R-HSA-201681	3.216846e-01	0.493
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.254047e-01	0.647
Formation of lateral plate mesoderm	R-HSA-9758920	3.346141e-01	0.475
Formation of apoptosome	R-HSA-111458	3.064128e-01	0.514
Activation of PUMA and translocation to mitochondria	R-HSA-139915	4.390094e-01	0.358
Elevation of cytosolic Ca2+ levels	R-HSA-139853	4.150366e-01	0.382
Downregulation of ERBB4 signaling	R-HSA-1253288	4.877860e-01	0.312
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.972074e-01	0.705
Regulation of CDH11 function	R-HSA-9762292	5.769263e-01	0.239
Diseases associated with the TLR signaling cascade	R-HSA-5602358	5.512384e-01	0.259
Diseases of Immune System	R-HSA-5260271	5.512384e-01	0.259
Activation of ATR in response to replication stress	R-HSA-176187	5.239298e-01	0.281
Interleukin-9 signaling	R-HSA-8985947	4.877860e-01	0.312
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	3.484664e-01	0.458
Late Phase of HIV Life Cycle	R-HSA-162599	2.215518e-01	0.655
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.354196e-01	0.474
Adrenoceptors	R-HSA-390696	2.268517e-01	0.644
Apoptotic factor-mediated response	R-HSA-111471	2.609451e-01	0.583
Signaling by WNT in cancer	R-HSA-4791275	2.109362e-01	0.676
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	3.484664e-01	0.458
Cation-coupled Chloride cotransporters	R-HSA-426117	4.390094e-01	0.358
Role of second messengers in netrin-1 signaling	R-HSA-418890	4.263255e-01	0.370
COPI-mediated anterograde transport	R-HSA-6807878	2.527289e-01	0.597
PKA activation	R-HSA-163615	4.478059e-01	0.349
Hedgehog 'off' state	R-HSA-5610787	3.037270e-01	0.518
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.732170e-01	0.242
Integration of energy metabolism	R-HSA-163685	2.141800e-01	0.669
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.494666e-01	0.603
S Phase	R-HSA-69242	2.194346e-01	0.659
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.409361e-01	0.467
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.182783e-01	0.285
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	2.268517e-01	0.644
Receptor Mediated Mitophagy	R-HSA-8934903	3.064128e-01	0.514
Repression of WNT target genes	R-HSA-4641265	4.263255e-01	0.370
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	4.219970e-01	0.375
NRIF signals cell death from the nucleus	R-HSA-205043	5.022295e-01	0.299
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	4.396934e-01	0.357
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.024316e-01	0.694
DNA Damage Bypass	R-HSA-73893	4.763709e-01	0.322
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.409361e-01	0.467
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	3.789783e-01	0.421
Toll-like Receptor Cascades	R-HSA-168898	4.036330e-01	0.394
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.152349e-01	0.382
Gastrulation	R-HSA-9758941	4.382671e-01	0.358
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	3.789783e-01	0.421
Activation of BH3-only proteins	R-HSA-114452	2.928567e-01	0.533
Signaling by Nuclear Receptors	R-HSA-9006931	2.723981e-01	0.565
Calcineurin activates NFAT	R-HSA-2025928	2.662767e-01	0.575
Transcription from mitochondrial promoters	R-HSA-75944	4.491189e-01	0.348
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.495960e-01	0.603
Abacavir transmembrane transport	R-HSA-2161517	3.877934e-01	0.411
Sensing of DNA Double Strand Breaks	R-HSA-5693548	3.868474e-01	0.412
Ca2+ activated K+ channels	R-HSA-1296052	4.390094e-01	0.358
TGFBR3 PTM regulation	R-HSA-9839383	4.877860e-01	0.312
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.877860e-01	0.312
Cardiogenesis	R-HSA-9733709	3.635868e-01	0.439
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	3.142352e-01	0.503
HDL assembly	R-HSA-8963896	5.022295e-01	0.299
GP1b-IX-V activation signalling	R-HSA-430116	5.338166e-01	0.273
Evasion by RSV of host interferon responses	R-HSA-9833109	4.736663e-01	0.325
Intraflagellar transport	R-HSA-5620924	4.557530e-01	0.341
Mitochondrial biogenesis	R-HSA-1592230	4.872498e-01	0.312
rRNA processing in the nucleus and cytosol	R-HSA-8868773	5.858602e-01	0.232
Cellular response to chemical stress	R-HSA-9711123	3.951169e-01	0.403
Signaling by FGFR in disease	R-HSA-1226099	2.479348e-01	0.606
Signaling by WNT	R-HSA-195721	4.844647e-01	0.315
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	2.505768e-01	0.601
Downregulation of ERBB2 signaling	R-HSA-8863795	2.928567e-01	0.533
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	3.818525e-01	0.418
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	4.612435e-01	0.336
Cellular responses to mechanical stimuli	R-HSA-9855142	2.567421e-01	0.591
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.819872e-01	0.235
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.454295e-01	0.610
TCR signaling	R-HSA-202403	4.549378e-01	0.342
Co-stimulation by CD28	R-HSA-389356	2.195961e-01	0.658
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.799660e-01	0.553
mTORC1-mediated signalling	R-HSA-166208	2.423641e-01	0.616
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	4.561009e-01	0.341
Host Interactions of HIV factors	R-HSA-162909	5.799114e-01	0.237
Interleukin-2 family signaling	R-HSA-451927	5.512384e-01	0.259
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	4.141902e-01	0.383
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	4.141902e-01	0.383
Signaling by LTK	R-HSA-9842663	2.180110e-01	0.662
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.495960e-01	0.603
Formation of intermediate mesoderm	R-HSA-9761174	3.064128e-01	0.514
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	3.151164e-01	0.502
Regulation of PTEN gene transcription	R-HSA-8943724	2.210005e-01	0.656
Eukaryotic Translation Termination	R-HSA-72764	3.215816e-01	0.493
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.382010e-01	0.269
Nuclear RNA decay	R-HSA-9930044	5.239298e-01	0.281
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.726345e-01	0.242
Metabolism of RNA	R-HSA-8953854	3.232749e-01	0.490
HIV Infection	R-HSA-162906	3.802440e-01	0.420
Transcriptional regulation by RUNX3	R-HSA-8878159	5.431520e-01	0.265
Neurofascin interactions	R-HSA-447043	3.877934e-01	0.411
Deubiquitination	R-HSA-5688426	3.965215e-01	0.402
Vesicle-mediated transport	R-HSA-5653656	3.533166e-01	0.452
Developmental Biology	R-HSA-1266738	3.474115e-01	0.459
Signaling by Hedgehog	R-HSA-5358351	5.365502e-01	0.270
Protein methylation	R-HSA-8876725	3.151164e-01	0.502
Regulation of RUNX2 expression and activity	R-HSA-8939902	5.773699e-01	0.239
Signaling by TGFB family members	R-HSA-9006936	5.675182e-01	0.246
Platelet degranulation	R-HSA-114608	5.436108e-01	0.265
Negative regulation of MAPK pathway	R-HSA-5675221	3.110355e-01	0.507
Reproduction	R-HSA-1474165	2.065324e-01	0.685
Manipulation of host energy metabolism	R-HSA-9636667	3.605605e-01	0.443
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	2.268517e-01	0.644
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.662767e-01	0.575
TRAIL signaling	R-HSA-75158	3.346141e-01	0.475
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.491189e-01	0.348
Regulation of cortical dendrite branching	R-HSA-8985801	4.491189e-01	0.348
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	4.491189e-01	0.348
Bicarbonate transporters	R-HSA-425381	3.467508e-01	0.460
Ionotropic activity of kainate receptors	R-HSA-451306	3.467508e-01	0.460
RET signaling	R-HSA-8853659	1.974530e-01	0.705
Amine ligand-binding receptors	R-HSA-375280	2.526519e-01	0.597
Ovarian tumor domain proteases	R-HSA-5689896	3.356213e-01	0.474
Vpr-mediated nuclear import of PICs	R-HSA-180910	3.356213e-01	0.474
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.877860e-01	0.312
Smooth Muscle Contraction	R-HSA-445355	3.047053e-01	0.516
Influenza Viral RNA Transcription and Replication	R-HSA-168273	2.875047e-01	0.541
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.811464e-01	0.419
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.479620e-01	0.349
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.906715e-01	0.309
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.684266e-01	0.329
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	5.182783e-01	0.285
Metalloprotease DUBs	R-HSA-5689901	5.182783e-01	0.285
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	4.831754e-01	0.316
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	5.418891e-01	0.266
Mitochondrial calcium ion transport	R-HSA-8949215	5.713899e-01	0.243
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.074633e-01	0.683
Cargo trafficking to the periciliary membrane	R-HSA-5620920	2.945559e-01	0.531
Transcriptional regulation of granulopoiesis	R-HSA-9616222	3.532182e-01	0.452
Signaling by ERBB4	R-HSA-1236394	4.493945e-01	0.347
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	5.330848e-01	0.273
Formation of the nephric duct	R-HSA-9830364	3.176751e-01	0.498
Signaling by PTK6	R-HSA-8848021	2.662101e-01	0.575
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.662101e-01	0.575
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.844482e-01	0.546
Pyroptosis	R-HSA-5620971	3.958728e-01	0.402
Interleukin-6 signaling	R-HSA-1059683	4.648710e-01	0.333
Oxidative Stress Induced Senescence	R-HSA-2559580	4.206735e-01	0.376
Interferon Signaling	R-HSA-913531	2.039340e-01	0.691
Signaling by NTRK2 (TRKB)	R-HSA-9006115	2.258163e-01	0.646
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	4.390094e-01	0.358
NOD1/2 Signaling Pathway	R-HSA-168638	2.712323e-01	0.567
Regulation of NPAS4 gene transcription	R-HSA-9768777	5.338166e-01	0.273
PECAM1 interactions	R-HSA-210990	3.467508e-01	0.460
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.494666e-01	0.603
Selenocysteine synthesis	R-HSA-2408557	3.169540e-01	0.499
MDK and PTN in ALK signaling	R-HSA-9851151	5.911512e-01	0.228
SARS-CoV-2-host interactions	R-HSA-9705683	3.290122e-01	0.483
Signaling by SCF-KIT	R-HSA-1433557	3.518683e-01	0.454
MAP kinase activation	R-HSA-450294	3.357369e-01	0.474
Interleukin-1 processing	R-HSA-448706	2.662767e-01	0.575
Syndecan interactions	R-HSA-3000170	2.669283e-01	0.574
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.505768e-01	0.601
CHL1 interactions	R-HSA-447041	4.390094e-01	0.358
Signal regulatory protein family interactions	R-HSA-391160	5.022295e-01	0.299
Ion channel transport	R-HSA-983712	3.173499e-01	0.498
Protein hydroxylation	R-HSA-9629569	5.113800e-01	0.291
Signaling by TGFBR3	R-HSA-9839373	5.539896e-01	0.256
Hemostasis	R-HSA-109582	5.865647e-01	0.232
Sensory processing of sound	R-HSA-9659379	3.211702e-01	0.493
PI5P Regulates TP53 Acetylation	R-HSA-6811555	4.648710e-01	0.333
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.745809e-01	0.561
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	3.593289e-01	0.445
Downstream signal transduction	R-HSA-186763	4.736663e-01	0.325
Interleukin-17 signaling	R-HSA-448424	4.951145e-01	0.305
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.684266e-01	0.329
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	5.002232e-01	0.301
Signal transduction by L1	R-HSA-445144	5.113800e-01	0.291
Interleukin-15 signaling	R-HSA-8983432	4.263255e-01	0.370
Ion transport by P-type ATPases	R-HSA-936837	2.819471e-01	0.550
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	3.346141e-01	0.475
DSCAM interactions	R-HSA-376172	4.491189e-01	0.348
Tandem pore domain potassium channels	R-HSA-1296346	3.064128e-01	0.514
Synthesis of PI	R-HSA-1483226	3.467508e-01	0.460
Formation of the anterior neural plate	R-HSA-9823739	3.151164e-01	0.502
Regulation of gene expression in beta cells	R-HSA-210745	2.699674e-01	0.569
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.521107e-01	0.598
Maturation of nucleoprotein	R-HSA-9683610	4.648710e-01	0.333
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	5.338166e-01	0.273
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	5.911512e-01	0.228
Sensory perception of sour taste	R-HSA-9729555	5.911512e-01	0.228
SLC-mediated transport of inorganic anions	R-HSA-9958790	5.059108e-01	0.296
Serotonin receptors	R-HSA-390666	5.769263e-01	0.239
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.769263e-01	0.239
SARS-CoV-1-host interactions	R-HSA-9692914	4.924942e-01	0.308
Negative regulation of FLT3	R-HSA-9706369	5.726345e-01	0.242
MITF-M-regulated melanocyte development	R-HSA-9730414	4.366762e-01	0.360
PTEN Regulation	R-HSA-6807070	5.488600e-01	0.261
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.268517e-01	0.644
Transcriptional Regulation by MECP2	R-HSA-8986944	2.425171e-01	0.615
Zygotic genome activation (ZGA)	R-HSA-9819196	3.467492e-01	0.460
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.185179e-01	0.661
Histamine receptors	R-HSA-390650	5.254169e-01	0.279
Signaling by ALK	R-HSA-201556	5.287852e-01	0.277
MITF-M-dependent gene expression	R-HSA-9856651	5.301185e-01	0.276
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.491189e-01	0.348
MECP2 regulates transcription factors	R-HSA-9022707	4.390094e-01	0.358
Interleukin-18 signaling	R-HSA-9012546	4.877860e-01	0.312
Interactions of Vpr with host cellular proteins	R-HSA-176033	4.020181e-01	0.396
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	4.242459e-01	0.372
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.911512e-01	0.228
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	5.769263e-01	0.239
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	5.334993e-01	0.273
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	4.895201e-01	0.310
Nephrin family interactions	R-HSA-373753	3.177669e-01	0.498
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.182783e-01	0.285
Influenza Infection	R-HSA-168255	2.827558e-01	0.549
Interleukin-12 family signaling	R-HSA-447115	3.611891e-01	0.442
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	4.114888e-01	0.386
Signaling by Leptin	R-HSA-2586552	3.064128e-01	0.514
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	2.801629e-01	0.553
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.346141e-01	0.475
Uptake and function of diphtheria toxin	R-HSA-5336415	4.390094e-01	0.358
OAS antiviral response	R-HSA-8983711	4.263255e-01	0.370
Respiratory syncytial virus genome replication	R-HSA-9834752	5.338166e-01	0.273
Gap junction assembly	R-HSA-190861	5.721506e-01	0.242
NPAS4 regulates expression of target genes	R-HSA-9768919	5.721506e-01	0.242
XBP1(S) activates chaperone genes	R-HSA-381038	3.461893e-01	0.461
IRE1alpha activates chaperones	R-HSA-381070	4.373660e-01	0.359
Interleukin-12 signaling	R-HSA-9020591	2.764787e-01	0.558
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	5.946736e-01	0.226
Degradation of GLI1 by the proteasome	R-HSA-5610780	5.946736e-01	0.226
HIV Transcription Initiation	R-HSA-167161	5.946736e-01	0.226
RNA Polymerase II Transcription Initiation	R-HSA-75953	5.946736e-01	0.226
Heme signaling	R-HSA-9707616	5.952947e-01	0.225
Downstream signaling of activated FGFR1	R-HSA-5654687	5.953351e-01	0.225
Downstream signaling of activated FGFR2	R-HSA-5654696	5.953351e-01	0.225
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.968478e-01	0.224
mRNA Capping	R-HSA-72086	5.968478e-01	0.224
Termination of translesion DNA synthesis	R-HSA-5656169	5.968478e-01	0.224
Signaling by CSF3 (G-CSF)	R-HSA-9674555	5.968478e-01	0.224
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.997937e-01	0.222
FGFR2 alternative splicing	R-HSA-6803529	5.997937e-01	0.222
Notch-HLH transcription pathway	R-HSA-350054	5.997937e-01	0.222
PI-3K cascade:FGFR1	R-HSA-5654689	5.997937e-01	0.222
Regulation of IFNA/IFNB signaling	R-HSA-912694	5.997937e-01	0.222
Transcriptional regulation by RUNX2	R-HSA-8878166	6.041083e-01	0.219
Phase 2 - plateau phase	R-HSA-5576893	6.054222e-01	0.218
Acetylcholine regulates insulin secretion	R-HSA-399997	6.054222e-01	0.218
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.054222e-01	0.218
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	6.054222e-01	0.218
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.054222e-01	0.218
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	6.054222e-01	0.218
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	6.054222e-01	0.218
Clathrin-mediated endocytosis	R-HSA-8856828	6.087350e-01	0.216
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.127265e-01	0.213
Signaling by EGFR	R-HSA-177929	6.132905e-01	0.212
Detoxification of Reactive Oxygen Species	R-HSA-3299685	6.132905e-01	0.212
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	6.170411e-01	0.210
Activated NTRK3 signals through RAS	R-HSA-9034864	6.170411e-01	0.210
FGFR2b ligand binding and activation	R-HSA-190377	6.170411e-01	0.210
Presynaptic depolarization and calcium channel opening	R-HSA-112308	6.170411e-01	0.210
Formation of the posterior neural plate	R-HSA-9832991	6.170411e-01	0.210
Interleukin-2 signaling	R-HSA-9020558	6.170411e-01	0.210
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	6.170411e-01	0.210
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	6.170411e-01	0.210
CD163 mediating an anti-inflammatory response	R-HSA-9662834	6.170411e-01	0.210
Triglyceride catabolism	R-HSA-163560	6.178346e-01	0.209
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	6.178346e-01	0.209
FLT3 signaling in disease	R-HSA-9682385	6.178346e-01	0.209
GPVI-mediated activation cascade	R-HSA-114604	6.178346e-01	0.209
Ribosome-associated quality control	R-HSA-9948299	6.194124e-01	0.208
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	6.213842e-01	0.207
GABA synthesis, release, reuptake and degradation	R-HSA-888590	6.213842e-01	0.207
SARS-CoV-2 Infection	R-HSA-9694516	6.259463e-01	0.203
Interleukin receptor SHC signaling	R-HSA-912526	6.270327e-01	0.203
Carnitine shuttle	R-HSA-200425	6.270327e-01	0.203
Growth hormone receptor signaling	R-HSA-982772	6.270327e-01	0.203
MAPK6/MAPK4 signaling	R-HSA-5687128	6.282455e-01	0.202
Hedgehog 'on' state	R-HSA-5632684	6.291364e-01	0.201
Insulin receptor signalling cascade	R-HSA-74751	6.300296e-01	0.201
Unfolded Protein Response (UPR)	R-HSA-381119	6.310920e-01	0.200
IRS-mediated signalling	R-HSA-112399	6.313428e-01	0.200
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	6.324036e-01	0.199
Regulation of RAS by GAPs	R-HSA-5658442	6.332168e-01	0.198
RNA Polymerase II Promoter Escape	R-HSA-73776	6.358621e-01	0.197
Constitutive Signaling by EGFRvIII	R-HSA-5637810	6.364939e-01	0.196
Signaling by EGFRvIII in Cancer	R-HSA-5637812	6.364939e-01	0.196
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.364939e-01	0.196
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.417809e-01	0.193
Ub-specific processing proteases	R-HSA-5689880	6.449657e-01	0.190
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	6.450073e-01	0.190
trans-Golgi Network Vesicle Budding	R-HSA-199992	6.451812e-01	0.190
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	6.477840e-01	0.189
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	6.477840e-01	0.189
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	6.477840e-01	0.189
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	6.477840e-01	0.189
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	6.477840e-01	0.189
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	6.477840e-01	0.189
Defective F9 activation	R-HSA-9673221	6.477840e-01	0.189
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	6.477840e-01	0.189
Activation of AKT2	R-HSA-165158	6.477840e-01	0.189
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	6.477840e-01	0.189
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	6.477840e-01	0.189
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	6.477840e-01	0.189
Muscarinic acetylcholine receptors	R-HSA-390648	6.477840e-01	0.189
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	6.477840e-01	0.189
Co-inhibition by BTLA	R-HSA-9927353	6.477840e-01	0.189
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	6.477840e-01	0.189
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	6.477840e-01	0.189
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	6.489318e-01	0.188
Meiotic recombination	R-HSA-912446	6.517604e-01	0.186
SHC-mediated cascade:FGFR1	R-HSA-5654688	6.530582e-01	0.185
Complex III assembly	R-HSA-9865881	6.530582e-01	0.185
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	6.530582e-01	0.185
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.530582e-01	0.185
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	6.530582e-01	0.185
ER to Golgi Anterograde Transport	R-HSA-199977	6.540869e-01	0.184
Activated NTRK2 signals through RAS	R-HSA-9026519	6.541635e-01	0.184
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	6.541635e-01	0.184
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	6.541635e-01	0.184
ERKs are inactivated	R-HSA-202670	6.541635e-01	0.184
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	6.541635e-01	0.184
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	6.541635e-01	0.184
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	6.541635e-01	0.184
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	6.541635e-01	0.184
Signaling by activated point mutants of FGFR1	R-HSA-1839122	6.541635e-01	0.184
Integration of provirus	R-HSA-162592	6.541635e-01	0.184
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	6.541635e-01	0.184
Signaling by FGFR2	R-HSA-5654738	6.590359e-01	0.181
MET promotes cell motility	R-HSA-8875878	6.606251e-01	0.180
SARS-CoV-1 Infection	R-HSA-9678108	6.653292e-01	0.177
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.658119e-01	0.177
Platelet sensitization by LDL	R-HSA-432142	6.658119e-01	0.177
Tie2 Signaling	R-HSA-210993	6.658119e-01	0.177
Nephron development	R-HSA-9831926	6.658119e-01	0.177
Regulation of beta-cell development	R-HSA-186712	6.660373e-01	0.177
Inwardly rectifying K+ channels	R-HSA-1296065	6.676829e-01	0.175
Nucleotide Excision Repair	R-HSA-5696398	6.679104e-01	0.175
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	6.697481e-01	0.174
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.697481e-01	0.174
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	6.745454e-01	0.171
FRS-mediated FGFR1 signaling	R-HSA-5654693	6.778381e-01	0.169
PI-3K cascade:FGFR2	R-HSA-5654695	6.778381e-01	0.169
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.778381e-01	0.169
Tight junction interactions	R-HSA-420029	6.778381e-01	0.169
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	6.778381e-01	0.169
TGFBR3 expression	R-HSA-9839394	6.778381e-01	0.169
Interleukin-7 signaling	R-HSA-1266695	6.778381e-01	0.169
Platelet homeostasis	R-HSA-418346	6.805780e-01	0.167
Stabilization of p53	R-HSA-69541	6.808587e-01	0.167
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	6.826425e-01	0.166
Regulation of PTEN stability and activity	R-HSA-8948751	6.871620e-01	0.163
RUNX3 regulates p14-ARF	R-HSA-8951936	6.883528e-01	0.162
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	6.883528e-01	0.162
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.883528e-01	0.162
Scavenging by Class F Receptors	R-HSA-3000484	6.883528e-01	0.162
Regulation of IFNG signaling	R-HSA-877312	6.883528e-01	0.162
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	6.883528e-01	0.162
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.883528e-01	0.162
RUNX3 regulates NOTCH signaling	R-HSA-8941856	6.883528e-01	0.162
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	6.883528e-01	0.162
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	6.883528e-01	0.162
Leading Strand Synthesis	R-HSA-69109	6.883528e-01	0.162
Polymerase switching	R-HSA-69091	6.883528e-01	0.162
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	6.883528e-01	0.162
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.928911e-01	0.159
mRNA Splicing - Minor Pathway	R-HSA-72165	6.928911e-01	0.159
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	6.928911e-01	0.159
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.933656e-01	0.159
E2F mediated regulation of DNA replication	R-HSA-113510	6.933656e-01	0.159
Regulation of signaling by CBL	R-HSA-912631	6.933656e-01	0.159
Other interleukin signaling	R-HSA-449836	6.933656e-01	0.159
Maturation of nucleoprotein	R-HSA-9694631	6.933656e-01	0.159
Cellular response to starvation	R-HSA-9711097	6.960426e-01	0.157
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.965750e-01	0.157
PKB-mediated events	R-HSA-109703	6.965750e-01	0.157
PDE3B signalling	R-HSA-165160	6.965750e-01	0.157
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.965750e-01	0.157
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.965750e-01	0.157
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.965750e-01	0.157
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	6.965750e-01	0.157
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.965750e-01	0.157
Signaling by RNF43 mutants	R-HSA-5340588	6.965750e-01	0.157
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.965750e-01	0.157
NGF-independant TRKA activation	R-HSA-187024	6.965750e-01	0.157
Pentose phosphate pathway disease	R-HSA-6791465	6.965750e-01	0.157
Phosphorylation of Emi1	R-HSA-176417	6.965750e-01	0.157
CDC6 association with the ORC:origin complex	R-HSA-68689	6.965750e-01	0.157
Noncanonical activation of NOTCH3	R-HSA-9017802	6.965750e-01	0.157
Formation of the Editosome	R-HSA-75094	6.965750e-01	0.157
Ceramide signalling	R-HSA-193681	6.965750e-01	0.157
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.965750e-01	0.157
Signalling to p38 via RIT and RIN	R-HSA-187706	6.965750e-01	0.157
Negative feedback regulation of MAPK pathway	R-HSA-5674499	6.965750e-01	0.157
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.965750e-01	0.157
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.965750e-01	0.157
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.965750e-01	0.157
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.965750e-01	0.157
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.965750e-01	0.157
Viral Messenger RNA Synthesis	R-HSA-168325	6.987335e-01	0.156
Formation of Incision Complex in GG-NER	R-HSA-5696395	7.002916e-01	0.155
Generation of second messenger molecules	R-HSA-202433	7.002916e-01	0.155
Glycogen metabolism	R-HSA-8982491	7.002916e-01	0.155
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	7.013560e-01	0.154
Myogenesis	R-HSA-525793	7.013560e-01	0.154
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.013560e-01	0.154
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.013560e-01	0.154
Translation initiation complex formation	R-HSA-72649	7.039880e-01	0.152
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	7.039880e-01	0.152
Signaling by NOTCH1	R-HSA-1980143	7.054056e-01	0.152
Interferon gamma signaling	R-HSA-877300	7.060249e-01	0.151
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	7.068342e-01	0.151
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	7.101044e-01	0.149
Miscellaneous transport and binding events	R-HSA-5223345	7.101044e-01	0.149
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	7.105532e-01	0.148
tRNA processing in the nucleus	R-HSA-6784531	7.142994e-01	0.146
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	7.155909e-01	0.145
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.191672e-01	0.143
Acetylcholine binding and downstream events	R-HSA-181431	7.197092e-01	0.143
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	7.197092e-01	0.143
FGFR2c ligand binding and activation	R-HSA-190375	7.197092e-01	0.143
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	7.197092e-01	0.143
FGFR1c ligand binding and activation	R-HSA-190373	7.197092e-01	0.143
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	7.197092e-01	0.143
Reversible hydration of carbon dioxide	R-HSA-1475029	7.197092e-01	0.143
FGFR4 ligand binding and activation	R-HSA-190322	7.197092e-01	0.143
Signaling by activated point mutants of FGFR3	R-HSA-1839130	7.197092e-01	0.143
rRNA modification in the mitochondrion	R-HSA-6793080	7.197092e-01	0.143
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	7.197092e-01	0.143
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	7.197092e-01	0.143
FGFR3 mutant receptor activation	R-HSA-2033514	7.197092e-01	0.143
CD28 dependent Vav1 pathway	R-HSA-389359	7.197092e-01	0.143
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	7.197092e-01	0.143
Signaling by NOTCH3	R-HSA-9012852	7.202158e-01	0.143
RNA Polymerase I Transcription Termination	R-HSA-73863	7.236085e-01	0.140
SHC-mediated cascade:FGFR2	R-HSA-5654699	7.236085e-01	0.140
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	7.236085e-01	0.140
Insulin processing	R-HSA-264876	7.236085e-01	0.140
GPER1 signaling	R-HSA-9634597	7.275224e-01	0.138
Metal ion SLC transporters	R-HSA-425410	7.275224e-01	0.138
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.293325e-01	0.137
Dual Incision in GG-NER	R-HSA-5696400	7.298297e-01	0.137
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	7.298297e-01	0.137
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	7.298297e-01	0.137
Signal amplification	R-HSA-392518	7.298297e-01	0.137
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	7.358383e-01	0.133
Ribosomal scanning and start codon recognition	R-HSA-72702	7.358383e-01	0.133
Signaling by FGFR1	R-HSA-5654736	7.358383e-01	0.133
Intra-Golgi traffic	R-HSA-6811438	7.367144e-01	0.133
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	7.379545e-01	0.132
Regulation of mitotic cell cycle	R-HSA-453276	7.379545e-01	0.132
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	7.379545e-01	0.132
Erythropoietin activates STAT5	R-HSA-9027283	7.386095e-01	0.132
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	7.386095e-01	0.132
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	7.386095e-01	0.132
NADPH regeneration	R-HSA-389542	7.386095e-01	0.132
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	7.386095e-01	0.132
Nef and signal transduction	R-HSA-164944	7.386095e-01	0.132
Cell-Cell communication	R-HSA-1500931	7.391154e-01	0.131
Activation of HOX genes during differentiation	R-HSA-5619507	7.425606e-01	0.129
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	7.425606e-01	0.129
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	7.432474e-01	0.129
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	7.432474e-01	0.129
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	7.432474e-01	0.129
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.432474e-01	0.129
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.432474e-01	0.129
Early Phase of HIV Life Cycle	R-HSA-162594	7.432474e-01	0.129
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.432474e-01	0.129
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	7.437943e-01	0.129
FRS-mediated FGFR2 signaling	R-HSA-5654700	7.446036e-01	0.128
Regulation of insulin secretion	R-HSA-422356	7.458569e-01	0.127
Prolactin receptor signaling	R-HSA-1170546	7.483614e-01	0.126
Removal of the Flap Intermediate	R-HSA-69166	7.483614e-01	0.126
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	7.483614e-01	0.126
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.483614e-01	0.126
FGFR3c ligand binding and activation	R-HSA-190372	7.483614e-01	0.126
Malate-aspartate shuttle	R-HSA-9856872	7.483614e-01	0.126
Regulation of KIT signaling	R-HSA-1433559	7.483614e-01	0.126
Physiological factors	R-HSA-5578768	7.483614e-01	0.126
Zinc transporters	R-HSA-435354	7.483614e-01	0.126
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	7.483614e-01	0.126
Transcriptional regulation by small RNAs	R-HSA-5578749	7.514860e-01	0.124
RNA Polymerase I Transcription Initiation	R-HSA-73762	7.536982e-01	0.123
C-type lectin receptors (CLRs)	R-HSA-5621481	7.602222e-01	0.119
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	7.635572e-01	0.117
Signaling by Erythropoietin	R-HSA-9006335	7.643593e-01	0.117
Ca2+ pathway	R-HSA-4086398	7.645304e-01	0.117
Dual incision in TC-NER	R-HSA-6782135	7.652562e-01	0.116
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	7.652562e-01	0.116
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.656518e-01	0.116
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.656518e-01	0.116
Signaling by PDGFR in disease	R-HSA-9671555	7.656518e-01	0.116
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.656518e-01	0.116
Vif-mediated degradation of APOBEC3G	R-HSA-180585	7.663167e-01	0.116
FGFR2 mutant receptor activation	R-HSA-1839126	7.663167e-01	0.116
Translesion synthesis by REV1	R-HSA-110312	7.744566e-01	0.111
SHC1 events in EGFR signaling	R-HSA-180336	7.744566e-01	0.111
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	7.744566e-01	0.111
Processive synthesis on the lagging strand	R-HSA-69183	7.744566e-01	0.111
Telomere C-strand synthesis initiation	R-HSA-174430	7.744566e-01	0.111
FGFR3 ligand binding and activation	R-HSA-190239	7.744566e-01	0.111
Lysosphingolipid and LPA receptors	R-HSA-419408	7.744566e-01	0.111
Biotin transport and metabolism	R-HSA-196780	7.744566e-01	0.111
Other semaphorin interactions	R-HSA-416700	7.744566e-01	0.111
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	7.748230e-01	0.111
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.748230e-01	0.111
FGFR3b ligand binding and activation	R-HSA-190371	7.748230e-01	0.111
Recycling of eIF2:GDP	R-HSA-72731	7.748230e-01	0.111
mRNA Editing: C to U Conversion	R-HSA-72200	7.748230e-01	0.111
PTK6 Expression	R-HSA-8849473	7.748230e-01	0.111
Nef Mediated CD4 Down-regulation	R-HSA-167590	7.748230e-01	0.111
Activated NTRK3 signals through PI3K	R-HSA-9603381	7.748230e-01	0.111
VLDL clearance	R-HSA-8964046	7.748230e-01	0.111
Activation of TRKA receptors	R-HSA-187015	7.748230e-01	0.111
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	7.748230e-01	0.111
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	7.748230e-01	0.111
Displacement of DNA glycosylase by APEX1	R-HSA-110357	7.748230e-01	0.111
Maturation of replicase proteins	R-HSA-9694301	7.748230e-01	0.111
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	7.769697e-01	0.110
Regulation of CDH1 Expression and Function	R-HSA-9764265	7.769697e-01	0.110
Extension of Telomeres	R-HSA-180786	7.790530e-01	0.108
Kidney development	R-HSA-9830369	7.840675e-01	0.106
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	7.850463e-01	0.105
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	7.852326e-01	0.105
Gap junction trafficking	R-HSA-190828	7.852326e-01	0.105
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.864374e-01	0.104
RAF-independent MAPK1/3 activation	R-HSA-112409	7.864374e-01	0.104
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.864374e-01	0.104
Chromosome Maintenance	R-HSA-73886	7.877028e-01	0.104
Uptake and actions of bacterial toxins	R-HSA-5339562	7.884347e-01	0.103
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.891599e-01	0.103
Protein ubiquitination	R-HSA-8852135	7.891599e-01	0.103
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	7.922469e-01	0.101
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	7.922469e-01	0.101
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	7.922469e-01	0.101
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	7.922469e-01	0.101
Signaling by NOTCH1 in Cancer	R-HSA-2644603	7.922469e-01	0.101
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.964297e-01	0.099
Class I peroxisomal membrane protein import	R-HSA-9603798	7.981534e-01	0.098
Translesion synthesis by POLI	R-HSA-5656121	7.981534e-01	0.098
Induction of Cell-Cell Fusion	R-HSA-9733458	7.981534e-01	0.098
Attachment and Entry	R-HSA-9678110	7.981534e-01	0.098
Regulation of BACH1 activity	R-HSA-9708530	7.981534e-01	0.098
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	7.981534e-01	0.098
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	7.981534e-01	0.098
Differentiation of T cells	R-HSA-9945266	7.981534e-01	0.098
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.981534e-01	0.098
Activation of SMO	R-HSA-5635838	7.981534e-01	0.098
Downstream TCR signaling	R-HSA-202424	7.992928e-01	0.097
Fanconi Anemia Pathway	R-HSA-6783310	7.998043e-01	0.097
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.998043e-01	0.097
Budding and maturation of HIV virion	R-HSA-162588	8.002641e-01	0.097
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.042544e-01	0.095
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	8.051808e-01	0.094
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.056700e-01	0.094
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.056700e-01	0.094
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	8.056700e-01	0.094
Interleukin-20 family signaling	R-HSA-8854691	8.056700e-01	0.094
EGFR interacts with phospholipase C-gamma	R-HSA-212718	8.060212e-01	0.094
MET receptor recycling	R-HSA-8875656	8.060212e-01	0.094
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	8.060212e-01	0.094
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	8.060212e-01	0.094
Co-stimulation by ICOS	R-HSA-9927354	8.060212e-01	0.094
Fructose biosynthesis	R-HSA-5652227	8.060212e-01	0.094
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	8.060212e-01	0.094
Nucleotide salvage defects	R-HSA-9734207	8.060212e-01	0.094
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	8.060212e-01	0.094
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	8.060212e-01	0.094
Activated NTRK2 signals through FYN	R-HSA-9032500	8.060212e-01	0.094
Alpha-defensins	R-HSA-1462054	8.060212e-01	0.094
Sodium/Proton exchangers	R-HSA-425986	8.060212e-01	0.094
Condensation of Prophase Chromosomes	R-HSA-2299718	8.135989e-01	0.090
Cell junction organization	R-HSA-446728	8.136530e-01	0.090
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.138448e-01	0.089
Pentose phosphate pathway	R-HSA-71336	8.138448e-01	0.089
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.138448e-01	0.089
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.164845e-01	0.088
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.196153e-01	0.086
Translesion synthesis by POLK	R-HSA-5655862	8.196153e-01	0.086
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.196153e-01	0.086
Disorders of Developmental Biology	R-HSA-9675151	8.196153e-01	0.086
Synthesis of PG	R-HSA-1483148	8.196153e-01	0.086
Deadenylation of mRNA	R-HSA-429947	8.234217e-01	0.084
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	8.234217e-01	0.084
Plasma lipoprotein assembly	R-HSA-8963898	8.234217e-01	0.084
Interleukin-6 family signaling	R-HSA-6783589	8.234217e-01	0.084
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	8.266349e-01	0.083
HDACs deacetylate histones	R-HSA-3214815	8.269659e-01	0.083
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	8.278551e-01	0.082
Nuclear signaling by ERBB4	R-HSA-1251985	8.278551e-01	0.082
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	8.311410e-01	0.080
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	8.311410e-01	0.080
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	8.311410e-01	0.080
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	8.328984e-01	0.079
MASTL Facilitates Mitotic Progression	R-HSA-2465910	8.328984e-01	0.079
Interleukin-21 signaling	R-HSA-9020958	8.328984e-01	0.079
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	8.328984e-01	0.079
Degradation of GABA	R-HSA-916853	8.328984e-01	0.079
MAPK1 (ERK2) activation	R-HSA-112411	8.328984e-01	0.079
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	8.328984e-01	0.079
Cellular response to mitochondrial stress	R-HSA-9840373	8.328984e-01	0.079
Defects in biotin (Btn) metabolism	R-HSA-3323169	8.328984e-01	0.079
Regulation of CDH11 gene transcription	R-HSA-9762293	8.328984e-01	0.079
Gluconeogenesis	R-HSA-70263	8.389331e-01	0.076
PI3K events in ERBB2 signaling	R-HSA-1963642	8.390066e-01	0.076
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	8.390066e-01	0.076
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.390066e-01	0.076
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.390066e-01	0.076
Regulation of NPAS4 gene expression	R-HSA-9768759	8.390066e-01	0.076
Uptake and function of anthrax toxins	R-HSA-5210891	8.390066e-01	0.076
SWI/SNF chromatin remodelers	R-HSA-9932451	8.397686e-01	0.076
ATP-dependent chromatin remodelers	R-HSA-9932444	8.397686e-01	0.076
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.397686e-01	0.076
Activation of G protein gated Potassium channels	R-HSA-1296041	8.397686e-01	0.076
G protein gated Potassium channels	R-HSA-1296059	8.397686e-01	0.076
Acyl chain remodelling of PS	R-HSA-1482801	8.397686e-01	0.076
rRNA processing	R-HSA-72312	8.406724e-01	0.075
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.409963e-01	0.075
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	8.409963e-01	0.075
Resolution of Abasic Sites (AP sites)	R-HSA-73933	8.409963e-01	0.075
Glucagon signaling in metabolic regulation	R-HSA-163359	8.456733e-01	0.073
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.456733e-01	0.073
GPCR downstream signalling	R-HSA-388396	8.500449e-01	0.071
Gap junction trafficking and regulation	R-HSA-157858	8.505165e-01	0.070
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.533003e-01	0.069
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.533003e-01	0.069
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.533003e-01	0.069
Signaling by EGFR in Cancer	R-HSA-1643713	8.547895e-01	0.068
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.547895e-01	0.068
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.547895e-01	0.068
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	8.560529e-01	0.067
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	8.560529e-01	0.067
Binding and entry of HIV virion	R-HSA-173107	8.560529e-01	0.067
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.560529e-01	0.067
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	8.560529e-01	0.067
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	8.560529e-01	0.067
Arachidonate production from DAG	R-HSA-426048	8.560529e-01	0.067
Interleukin-27 signaling	R-HSA-9020956	8.560529e-01	0.067
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.560529e-01	0.067
Maturation of spike protein	R-HSA-9683686	8.560529e-01	0.067
MAPK3 (ERK1) activation	R-HSA-110056	8.560529e-01	0.067
Defective factor IX causes hemophilia B	R-HSA-9668250	8.560529e-01	0.067
Sperm Motility And Taxes	R-HSA-1300642	8.560529e-01	0.067
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.560529e-01	0.067
Josephin domain DUBs	R-HSA-5689877	8.560529e-01	0.067
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.564890e-01	0.067
GAB1 signalosome	R-HSA-180292	8.564890e-01	0.067
Activated point mutants of FGFR2	R-HSA-2033519	8.564890e-01	0.067
FGFR1 ligand binding and activation	R-HSA-190242	8.564890e-01	0.067
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	8.564890e-01	0.067
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	8.564890e-01	0.067
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	8.564890e-01	0.067
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	8.587357e-01	0.066
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	8.587357e-01	0.066
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	8.587357e-01	0.066
Signaling by FGFR2 in disease	R-HSA-5655253	8.614093e-01	0.065
Interferon alpha/beta signaling	R-HSA-909733	8.625396e-01	0.064
Cytosolic tRNA aminoacylation	R-HSA-379716	8.648008e-01	0.063
Maternal to zygotic transition (MZT)	R-HSA-9816359	8.650624e-01	0.063
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.684249e-01	0.061
Packaging Of Telomere Ends	R-HSA-171306	8.685640e-01	0.061
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.685640e-01	0.061
Signaling by FGFR3 in disease	R-HSA-5655332	8.685640e-01	0.061
Triglyceride metabolism	R-HSA-8979227	8.694819e-01	0.061
PERK regulates gene expression	R-HSA-381042	8.708424e-01	0.060
Oncogene Induced Senescence	R-HSA-2559585	8.708424e-01	0.060
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.722190e-01	0.059
Crosslinking of collagen fibrils	R-HSA-2243919	8.722190e-01	0.059
Conjugation of benzoate with glycine	R-HSA-177135	8.760002e-01	0.057
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.760002e-01	0.057
vRNA Synthesis	R-HSA-192814	8.760002e-01	0.057
vRNP Assembly	R-HSA-192905	8.760002e-01	0.057
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	8.760002e-01	0.057
Transport of RCbl within the body	R-HSA-9758890	8.760002e-01	0.057
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	8.760002e-01	0.057
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.760002e-01	0.057
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	8.760002e-01	0.057
Suppression of apoptosis	R-HSA-9635465	8.760002e-01	0.057
Prostanoid ligand receptors	R-HSA-391908	8.760002e-01	0.057
UCH proteinases	R-HSA-5689603	8.767950e-01	0.057
GABA receptor activation	R-HSA-977443	8.786513e-01	0.056
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.811714e-01	0.055
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.811714e-01	0.055
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	8.812266e-01	0.055
Inositol phosphate metabolism	R-HSA-1483249	8.812385e-01	0.055
PRC2 methylates histones and DNA	R-HSA-212300	8.820436e-01	0.055
Lysosome Vesicle Biogenesis	R-HSA-432720	8.820436e-01	0.055
RUNX2 regulates bone development	R-HSA-8941326	8.820436e-01	0.055
RMTs methylate histone arginines	R-HSA-3214858	8.855312e-01	0.053
Signaling by FGFR	R-HSA-190236	8.855353e-01	0.053
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	8.863466e-01	0.052
Signaling by NODAL	R-HSA-1181150	8.863466e-01	0.052
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.863466e-01	0.052
Pregnenolone biosynthesis	R-HSA-196108	8.863466e-01	0.052
Regulation of T cell activation by CD28 family	R-HSA-388841	8.876569e-01	0.052
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	8.902047e-01	0.051
Immune System	R-HSA-168256	8.907790e-01	0.050
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.923897e-01	0.049
Cleavage of the damaged purine	R-HSA-110331	8.923897e-01	0.049
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.926900e-01	0.049
Regulation of CDH11 Expression and Function	R-HSA-9759475	8.926900e-01	0.049
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.931843e-01	0.049
Plasmalogen biosynthesis	R-HSA-75896	8.931843e-01	0.049
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	8.931843e-01	0.049
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.931843e-01	0.049
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.948328e-01	0.048
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	8.948328e-01	0.048
Mitochondrial protein import	R-HSA-1268020	8.953841e-01	0.048
Signaling by PDGF	R-HSA-186797	8.953841e-01	0.048
G-protein activation	R-HSA-202040	8.990137e-01	0.046
FGFR2 ligand binding and activation	R-HSA-190241	8.990137e-01	0.046
Signalling to RAS	R-HSA-167044	8.990137e-01	0.046
Lagging Strand Synthesis	R-HSA-69186	8.990137e-01	0.046
Basigin interactions	R-HSA-210991	8.990137e-01	0.046
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.019309e-01	0.045
Depurination	R-HSA-73927	9.019309e-01	0.045
Elastic fibre formation	R-HSA-1566948	9.019309e-01	0.045
Activation of the pre-replicative complex	R-HSA-68962	9.031960e-01	0.044
DAP12 signaling	R-HSA-2424491	9.031960e-01	0.044
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.031960e-01	0.044
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.031960e-01	0.044
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.034731e-01	0.044
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.034731e-01	0.044
Selenoamino acid metabolism	R-HSA-2408522	9.038511e-01	0.044
G alpha (s) signalling events	R-HSA-418555	9.054905e-01	0.043
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	9.079878e-01	0.042
Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77285	9.079878e-01	0.042
GRB2 events in EGFR signaling	R-HSA-179812	9.079878e-01	0.042
Serotonin clearance from the synaptic cleft	R-HSA-380615	9.079878e-01	0.042
VLDLR internalisation and degradation	R-HSA-8866427	9.079878e-01	0.042
Conjugation of salicylate with glycine	R-HSA-177128	9.079878e-01	0.042
Interleukin-35 Signalling	R-HSA-8984722	9.079878e-01	0.042
MET activates RAS signaling	R-HSA-8851805	9.079878e-01	0.042
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	9.079878e-01	0.042
Trafficking and processing of endosomal TLR	R-HSA-1679131	9.079878e-01	0.042
Disorders of Nervous System Development	R-HSA-9697154	9.079878e-01	0.042
Pervasive developmental disorders	R-HSA-9005895	9.079878e-01	0.042
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	9.079878e-01	0.042
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	9.079878e-01	0.042
Estrogen biosynthesis	R-HSA-193144	9.079878e-01	0.042
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.099557e-01	0.041
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	9.103536e-01	0.041
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.103536e-01	0.041
Attachment and Entry	R-HSA-9694614	9.103536e-01	0.041
Listeria monocytogenes entry into host cells	R-HSA-8876384	9.103536e-01	0.041
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.114880e-01	0.040
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.114880e-01	0.040
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.127631e-01	0.040
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	9.137451e-01	0.039
Switching of origins to a post-replicative state	R-HSA-69052	9.141469e-01	0.039
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	9.145240e-01	0.039
Cellular response to hypoxia	R-HSA-1234174	9.167964e-01	0.038
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.187939e-01	0.037
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.187939e-01	0.037
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.187939e-01	0.037
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	9.189126e-01	0.037
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.204910e-01	0.036
Fructose metabolism	R-HSA-5652084	9.204910e-01	0.036
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.204910e-01	0.036
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.204910e-01	0.036
LDL clearance	R-HSA-8964038	9.204910e-01	0.036
Signaling by KIT in disease	R-HSA-9669938	9.204910e-01	0.036
Cellular hexose transport	R-HSA-189200	9.204910e-01	0.036
Neurotoxicity of clostridium toxins	R-HSA-168799	9.204910e-01	0.036
Adenylate cyclase activating pathway	R-HSA-170660	9.207405e-01	0.036
Processing of SMDT1	R-HSA-8949664	9.207405e-01	0.036
Membrane binding and targetting of GAG proteins	R-HSA-174490	9.207405e-01	0.036
Mtb iron assimilation by chelation	R-HSA-1222449	9.207405e-01	0.036
Diseases of nucleotide metabolism	R-HSA-9735804	9.207405e-01	0.036
Platelet Adhesion to exposed collagen	R-HSA-75892	9.207405e-01	0.036
Replication of the SARS-CoV-1 genome	R-HSA-9682706	9.207405e-01	0.036
Phospholipid metabolism	R-HSA-1483257	9.219172e-01	0.035
Neurotransmitter release cycle	R-HSA-112310	9.224406e-01	0.035
Degradation of CDH1	R-HSA-9766229	9.257814e-01	0.033
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.262105e-01	0.033
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.262105e-01	0.033
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.262105e-01	0.033
Maturation of spike protein	R-HSA-9694548	9.262105e-01	0.033
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.268839e-01	0.033
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.293604e-01	0.032
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	9.293604e-01	0.032
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	9.293604e-01	0.032
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.295411e-01	0.032
RNA Polymerase I Promoter Clearance	R-HSA-73854	9.313593e-01	0.031
Retrograde neurotrophin signalling	R-HSA-177504	9.317263e-01	0.031
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	9.317263e-01	0.031
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	9.317263e-01	0.031
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	9.317263e-01	0.031
Signaling by FGFR4 in disease	R-HSA-5655291	9.317263e-01	0.031
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	9.317263e-01	0.031
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	9.317263e-01	0.031
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	9.317263e-01	0.031
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77348	9.317263e-01	0.031
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77350	9.317263e-01	0.031
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77310	9.317263e-01	0.031
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	9.317263e-01	0.031
Glycerophospholipid catabolism	R-HSA-6814848	9.317263e-01	0.031
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.317263e-01	0.031
Ciprofloxacin ADME	R-HSA-9793528	9.317263e-01	0.031
Synthesis of IPs in the nucleus	R-HSA-1855191	9.317263e-01	0.031
Acyl chain remodeling of CL	R-HSA-1482798	9.317263e-01	0.031
P2Y receptors	R-HSA-417957	9.317263e-01	0.031
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	9.317263e-01	0.031
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.327671e-01	0.030
Translation of Structural Proteins	R-HSA-9683701	9.330110e-01	0.030
Acyl chain remodelling of PC	R-HSA-1482788	9.365220e-01	0.028
Signaling by Insulin receptor	R-HSA-74752	9.370244e-01	0.028
TNFs bind their physiological receptors	R-HSA-5669034	9.376107e-01	0.028
The phototransduction cascade	R-HSA-2514856	9.379849e-01	0.028
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.382270e-01	0.028
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.387746e-01	0.027
Activation of GABAB receptors	R-HSA-991365	9.392385e-01	0.027
GABA B receptor activation	R-HSA-977444	9.392385e-01	0.027
G alpha (q) signalling events	R-HSA-416476	9.408891e-01	0.026
RNA Polymerase I Transcription	R-HSA-73864	9.410897e-01	0.026
HCMV Early Events	R-HSA-9609690	9.411294e-01	0.026
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.411899e-01	0.026
G beta:gamma signalling through BTK	R-HSA-8964315	9.411899e-01	0.026
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	9.411899e-01	0.026
Signaling by Activin	R-HSA-1502540	9.411899e-01	0.026
p38MAPK events	R-HSA-171007	9.411899e-01	0.026
Protein repair	R-HSA-5676934	9.411899e-01	0.026
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	9.411899e-01	0.026
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	9.411899e-01	0.026
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	9.411899e-01	0.026
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	9.411899e-01	0.026
Potential therapeutics for SARS	R-HSA-9679191	9.413435e-01	0.026
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.421168e-01	0.026
eNOS activation	R-HSA-203615	9.430072e-01	0.025
Signaling by NOTCH2	R-HSA-1980145	9.430072e-01	0.025
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.430072e-01	0.025
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.430072e-01	0.025
Aquaporin-mediated transport	R-HSA-445717	9.432886e-01	0.025
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.433836e-01	0.025
Orc1 removal from chromatin	R-HSA-68949	9.433836e-01	0.025
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.433836e-01	0.025
RNA Polymerase I Promoter Escape	R-HSA-73772	9.433836e-01	0.025
Beta-catenin independent WNT signaling	R-HSA-3858494	9.445710e-01	0.025
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.449344e-01	0.025
Defective pyroptosis	R-HSA-9710421	9.449344e-01	0.025
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.449344e-01	0.025
Mitochondrial protein degradation	R-HSA-9837999	9.453695e-01	0.024
Collagen formation	R-HSA-1474290	9.453695e-01	0.024
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.454831e-01	0.024
SARS-CoV Infections	R-HSA-9679506	9.457461e-01	0.024
NCAM signaling for neurite out-growth	R-HSA-375165	9.479758e-01	0.023
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.479758e-01	0.023
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.483542e-01	0.023
NoRC negatively regulates rRNA expression	R-HSA-427413	9.484926e-01	0.023
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	R-HSA-2142816	9.493423e-01	0.023
Defective GALNT3 causes HFTC	R-HSA-5083625	9.493423e-01	0.023
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.493423e-01	0.023
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.493423e-01	0.023
Serotonin and melatonin biosynthesis	R-HSA-209931	9.493423e-01	0.023
Fructose catabolism	R-HSA-70350	9.493423e-01	0.023
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.493423e-01	0.023
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	9.493423e-01	0.023
Atorvastatin ADME	R-HSA-9754706	9.493423e-01	0.023
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	9.495842e-01	0.022
Signaling by MET	R-HSA-6806834	9.495842e-01	0.022
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.511913e-01	0.022
Abacavir ADME	R-HSA-2161522	9.511913e-01	0.022
Adipogenesis	R-HSA-9843745	9.512070e-01	0.022
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.529257e-01	0.021
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.541715e-01	0.020
RNA Polymerase III Transcription	R-HSA-74158	9.541715e-01	0.020
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.548859e-01	0.020
G beta:gamma signalling through CDC42	R-HSA-8964616	9.563649e-01	0.019
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.563649e-01	0.019
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	9.563649e-01	0.019
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.563649e-01	0.019
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	R-HSA-77288	9.563649e-01	0.019
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77346	9.563649e-01	0.019
Galactose catabolism	R-HSA-70370	9.563649e-01	0.019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.563649e-01	0.019
tRNA modification in the mitochondrion	R-HSA-6787450	9.563649e-01	0.019
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.563649e-01	0.019
RNA Polymerase I Promoter Opening	R-HSA-73728	9.568738e-01	0.019
Maturation of hRSV A proteins	R-HSA-9828806	9.568738e-01	0.019
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.571256e-01	0.019
G alpha (z) signalling events	R-HSA-418597	9.571256e-01	0.019
Degradation of AXIN	R-HSA-4641257	9.589530e-01	0.018
Degradation of DVL	R-HSA-4641258	9.589530e-01	0.018
Telomere Maintenance	R-HSA-157579	9.591987e-01	0.018
Adherens junctions interactions	R-HSA-418990	9.596385e-01	0.018
Signaling by NOTCH4	R-HSA-9013694	9.598755e-01	0.018
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.602893e-01	0.018
Cytoprotection by HMOX1	R-HSA-9707564	9.602893e-01	0.018
Pyrimidine salvage	R-HSA-73614	9.619191e-01	0.017
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.619191e-01	0.017
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.624144e-01	0.017
Regulation of FZD by ubiquitination	R-HSA-4641263	9.624144e-01	0.017
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	9.624144e-01	0.017
Sulfide oxidation to sulfate	R-HSA-1614517	9.624144e-01	0.017
Catecholamine biosynthesis	R-HSA-209905	9.624144e-01	0.017
GDP-fucose biosynthesis	R-HSA-6787639	9.624144e-01	0.017
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.624144e-01	0.017
Cell-cell junction organization	R-HSA-421270	9.630794e-01	0.016
Regulation of CDH1 Function	R-HSA-9764561	9.645142e-01	0.016
Gene Silencing by RNA	R-HSA-211000	9.659155e-01	0.015
DNA methylation	R-HSA-5334118	9.663949e-01	0.015
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.663949e-01	0.015
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.663949e-01	0.015
Glucagon-type ligand receptors	R-HSA-420092	9.663949e-01	0.015
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.667062e-01	0.015
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.671442e-01	0.015
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	R-HSA-2142670	9.676255e-01	0.014
RNA Polymerase III Transcription Termination	R-HSA-73980	9.676255e-01	0.014
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	9.676255e-01	0.014
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.676255e-01	0.014
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.676255e-01	0.014
Vitamin D (calciferol) metabolism	R-HSA-196791	9.676255e-01	0.014
Co-inhibition by PD-1	R-HSA-389948	9.687104e-01	0.014
Translation of Structural Proteins	R-HSA-9694635	9.689343e-01	0.014
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.692341e-01	0.014
Assembly of the pre-replicative complex	R-HSA-68867	9.692341e-01	0.014
Protein localization	R-HSA-9609507	9.697858e-01	0.013
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.703619e-01	0.013
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.706358e-01	0.013
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.706358e-01	0.013
Peroxisomal protein import	R-HSA-9033241	9.707133e-01	0.013
PCP/CE pathway	R-HSA-4086400	9.715114e-01	0.013
Transport to the Golgi and subsequent modification	R-HSA-948021	9.720445e-01	0.012
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.721143e-01	0.012
Pyrimidine biosynthesis	R-HSA-500753	9.721143e-01	0.012
Amino Acid conjugation	R-HSA-156587	9.721143e-01	0.012
Conjugation of carboxylic acids	R-HSA-159424	9.721143e-01	0.012
Translesion Synthesis by POLH	R-HSA-110320	9.721143e-01	0.012
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	9.721143e-01	0.012
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.721143e-01	0.012
Diseases of hemostasis	R-HSA-9671793	9.721143e-01	0.012
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.721143e-01	0.012
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.721143e-01	0.012
tRNA Aminoacylation	R-HSA-379724	9.734215e-01	0.012
Circadian clock	R-HSA-9909396	9.734552e-01	0.012
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.735907e-01	0.012
Hh mutants are degraded by ERAD	R-HSA-5362768	9.737739e-01	0.012
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.738751e-01	0.011
Cargo concentration in the ER	R-HSA-5694530	9.738751e-01	0.011
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.738751e-01	0.011
Molecules associated with elastic fibres	R-HSA-2129379	9.738751e-01	0.011
COPII-mediated vesicle transport	R-HSA-204005	9.745791e-01	0.011
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.746628e-01	0.011
Signaling by GPCR	R-HSA-372790	9.749596e-01	0.011
Hedgehog ligand biogenesis	R-HSA-5358346	9.756353e-01	0.011
Formation of paraxial mesoderm	R-HSA-9793380	9.758953e-01	0.011
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.759810e-01	0.011
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	9.759810e-01	0.011
Acyl chain remodelling of PI	R-HSA-1482922	9.759810e-01	0.011
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.759810e-01	0.011
Eicosanoid ligand-binding receptors	R-HSA-391903	9.759810e-01	0.011
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.765918e-01	0.010
DNA strand elongation	R-HSA-69190	9.769842e-01	0.010
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.769842e-01	0.010
Cleavage of the damaged pyrimidine	R-HSA-110329	9.791200e-01	0.009
Depyrimidination	R-HSA-73928	9.791200e-01	0.009
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.793117e-01	0.009
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.793117e-01	0.009
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.793117e-01	0.009
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.793117e-01	0.009
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.793117e-01	0.009
Base Excision Repair	R-HSA-73884	9.795656e-01	0.009
Adaptive Immune System	R-HSA-1280218	9.799145e-01	0.009
Amino acids regulate mTORC1	R-HSA-9639288	9.802666e-01	0.009
Response of Mtb to phagocytosis	R-HSA-9637690	9.813865e-01	0.008
Vpu mediated degradation of CD4	R-HSA-180534	9.821633e-01	0.008
Heme degradation	R-HSA-189483	9.821633e-01	0.008
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.821807e-01	0.008
Molybdenum cofactor biosynthesis	R-HSA-947581	9.821807e-01	0.008
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.821807e-01	0.008
Assembly Of The HIV Virion	R-HSA-175474	9.821807e-01	0.008
Serine metabolism	R-HSA-977347	9.821807e-01	0.008
Glutathione synthesis and recycling	R-HSA-174403	9.821807e-01	0.008
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.822575e-01	0.008
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.825731e-01	0.008
Synthesis of DNA	R-HSA-69239	9.825741e-01	0.008
HCMV Infection	R-HSA-9609646	9.830061e-01	0.007
DAP12 interactions	R-HSA-2172127	9.834166e-01	0.007
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.843090e-01	0.007
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.843090e-01	0.007
Hyaluronan metabolism	R-HSA-2142845	9.843090e-01	0.007
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.846520e-01	0.007
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.846520e-01	0.007
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	9.846520e-01	0.007
Biosynthesis of D-series resolvins	R-HSA-9018676	9.846520e-01	0.007
Ethanol oxidation	R-HSA-71384	9.846520e-01	0.007
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.846520e-01	0.007
DNA Replication Pre-Initiation	R-HSA-69002	9.851757e-01	0.006
Somitogenesis	R-HSA-9824272	9.852337e-01	0.006
Parasite infection	R-HSA-9664407	9.859669e-01	0.006
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.859669e-01	0.006
Leishmania phagocytosis	R-HSA-9664417	9.859669e-01	0.006
Transferrin endocytosis and recycling	R-HSA-917977	9.862028e-01	0.006
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.862028e-01	0.006
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.862028e-01	0.006
Acyl chain remodelling of PE	R-HSA-1482839	9.862028e-01	0.006
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.862028e-01	0.006
Regulation of Apoptosis	R-HSA-169911	9.862028e-01	0.006
Termination of O-glycan biosynthesis	R-HSA-977068	9.867806e-01	0.006
Free fatty acids regulate insulin secretion	R-HSA-400451	9.867806e-01	0.006
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.867806e-01	0.006
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.867806e-01	0.006
ABC transporters in lipid homeostasis	R-HSA-1369062	9.867806e-01	0.006
Biosynthesis of maresins	R-HSA-9018682	9.867806e-01	0.006
Signaling by NOTCH	R-HSA-157118	9.880771e-01	0.005
ABC transporter disorders	R-HSA-5619084	9.880783e-01	0.005
Integrin cell surface interactions	R-HSA-216083	9.880783e-01	0.005
Synthesis of PC	R-HSA-1483191	9.883115e-01	0.005
Parasitic Infection Pathways	R-HSA-9824443	9.884107e-01	0.005
Leishmania infection	R-HSA-9658195	9.884107e-01	0.005
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.886142e-01	0.005
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.886142e-01	0.005
Synthesis of dolichyl-phosphate	R-HSA-446199	9.886142e-01	0.005
Mitochondrial RNA degradation	R-HSA-9836573	9.886142e-01	0.005
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.893459e-01	0.005
SLC-mediated transport of organic cations	R-HSA-549127	9.893459e-01	0.005
NCAM1 interactions	R-HSA-419037	9.893459e-01	0.005
Deadenylation-dependent mRNA decay	R-HSA-429914	9.896662e-01	0.005
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.901935e-01	0.004
Alpha-oxidation of phytanate	R-HSA-389599	9.901935e-01	0.004
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.901935e-01	0.004
Hyaluronan degradation	R-HSA-2160916	9.901935e-01	0.004
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	9.901935e-01	0.004
Fertilization	R-HSA-1187000	9.901935e-01	0.004
Laminin interactions	R-HSA-3000157	9.901935e-01	0.004
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.901935e-01	0.004
Signaling by Retinoic Acid	R-HSA-5362517	9.907404e-01	0.004
MET activates PTK2 signaling	R-HSA-8874081	9.915538e-01	0.004
Urea cycle	R-HSA-70635	9.915538e-01	0.004
Sphingolipid catabolism	R-HSA-9845614	9.915538e-01	0.004
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.915538e-01	0.004
Suppression of phagosomal maturation	R-HSA-9637687	9.915538e-01	0.004
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.917860e-01	0.004
Plasma lipoprotein clearance	R-HSA-8964043	9.917860e-01	0.004
RAS processing	R-HSA-9648002	9.917860e-01	0.004
Pre-NOTCH Transcription and Translation	R-HSA-1912408	9.920313e-01	0.003
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.927206e-01	0.003
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.927255e-01	0.003
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.927255e-01	0.003
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	9.927255e-01	0.003
Triglyceride biosynthesis	R-HSA-75109	9.927255e-01	0.003
Synthesis of PE	R-HSA-1483213	9.927255e-01	0.003
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.927255e-01	0.003
Signaling by BMP	R-HSA-201451	9.927255e-01	0.003
rRNA processing in the mitochondrion	R-HSA-8868766	9.927918e-01	0.003
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.927918e-01	0.003
ABC-family proteins mediated transport	R-HSA-382556	9.929475e-01	0.003
SLC transporter disorders	R-HSA-5619102	9.935354e-01	0.003
Prednisone ADME	R-HSA-9757110	9.937347e-01	0.003
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.942297e-01	0.003
Citric acid cycle (TCA cycle)	R-HSA-71403	9.942297e-01	0.003
Degradation of CRY and PER proteins	R-HSA-9932298	9.944548e-01	0.002
Thyroxine biosynthesis	R-HSA-209968	9.946040e-01	0.002
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.946040e-01	0.002
Viral Infection Pathways	R-HSA-9824446	9.949504e-01	0.002
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.951388e-01	0.002
DNA Replication	R-HSA-69306	9.951444e-01	0.002
FCERI mediated NF-kB activation	R-HSA-2871837	9.951612e-01	0.002
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.952571e-01	0.002
Neurotransmitter clearance	R-HSA-112311	9.953527e-01	0.002
Innate Immune System	R-HSA-168249	9.955744e-01	0.002
Cholesterol biosynthesis	R-HSA-191273	9.958081e-01	0.002
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	9.959975e-01	0.002
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.959975e-01	0.002
Metabolism of amine-derived hormones	R-HSA-209776	9.960137e-01	0.002
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.962193e-01	0.002
Proteasome assembly	R-HSA-9907900	9.962677e-01	0.002
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.962677e-01	0.002
Surfactant metabolism	R-HSA-5683826	9.962677e-01	0.002
ER-Phagosome pathway	R-HSA-1236974	9.964089e-01	0.002
HCMV Late Events	R-HSA-9610379	9.964652e-01	0.002
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.966418e-01	0.001
Asymmetric localization of PCP proteins	R-HSA-4608870	9.967311e-01	0.001
Antigen processing-Cross presentation	R-HSA-1236975	9.969658e-01	0.001
Amyloid fiber formation	R-HSA-977225	9.969670e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.969914e-01	0.001
Recycling of bile acids and salts	R-HSA-159418	9.970313e-01	0.001
Regulation of pyruvate metabolism	R-HSA-9861718	9.971378e-01	0.001
Metabolism of cofactors	R-HSA-8978934	9.973178e-01	0.001
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	9.975554e-01	0.001
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.976097e-01	0.001
Regulation of endogenous retroelements	R-HSA-9842860	9.977641e-01	0.001
RA biosynthesis pathway	R-HSA-5365859	9.977981e-01	0.001
Calnexin/calreticulin cycle	R-HSA-901042	9.977981e-01	0.001
Collagen degradation	R-HSA-1442490	9.978387e-01	0.001
Nucleotide salvage	R-HSA-8956321	9.978387e-01	0.001
PPARA activates gene expression	R-HSA-1989781	9.980502e-01	0.001
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.980819e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.980819e-01	0.001
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.981038e-01	0.001
ROS and RNS production in phagocytes	R-HSA-1222556	9.981040e-01	0.001
Iron uptake and transport	R-HSA-917937	9.983123e-01	0.001
RSV-host interactions	R-HSA-9833110	9.983493e-01	0.001
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.983550e-01	0.001
Glycosphingolipid transport	R-HSA-9845576	9.983670e-01	0.001
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.983670e-01	0.001
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.984300e-01	0.001
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.985937e-01	0.001
Collagen chain trimerization	R-HSA-8948216	9.985937e-01	0.001
Metabolism of folate and pterines	R-HSA-196757	9.985937e-01	0.001
Pyruvate metabolism	R-HSA-70268	9.985951e-01	0.001
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.987378e-01	0.001
Purine salvage	R-HSA-74217	9.987889e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.988123e-01	0.001
Nucleotide biosynthesis	R-HSA-8956320	9.988791e-01	0.000
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.989570e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.989657e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.989751e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.989751e-01	0.000
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.991018e-01	0.000
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.992265e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.992480e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.992689e-01	0.000
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.992841e-01	0.000
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.992972e-01	0.000
Neddylation	R-HSA-8951664	9.993060e-01	0.000
Scavenging by Class A Receptors	R-HSA-3000480	9.993339e-01	0.000
Heme biosynthesis	R-HSA-189451	9.993339e-01	0.000
Synthesis of PA	R-HSA-1483166	9.993474e-01	0.000
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.993491e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.993806e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.994904e-01	0.000
Defensins	R-HSA-1461973	9.995061e-01	0.000
tRNA processing	R-HSA-72306	9.995179e-01	0.000
Metabolism of polyamines	R-HSA-351202	9.995659e-01	0.000
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.995747e-01	0.000
Endogenous sterols	R-HSA-211976	9.996212e-01	0.000
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	9.996337e-01	0.000
Degradation of cysteine and homocysteine	R-HSA-1614558	9.996337e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.997118e-01	0.000
Azathioprine ADME	R-HSA-9748787	9.998266e-01	0.000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.998266e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998335e-01	0.000
Complex IV assembly	R-HSA-9864848	9.998507e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.998549e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.998835e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.999040e-01	0.000
Paracetamol ADME	R-HSA-9753281	9.999179e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999233e-01	0.000
Post-translational protein phosphorylation	R-HSA-8957275	9.999267e-01	0.000
Digestion	R-HSA-8935690	9.999293e-01	0.000
Dectin-2 family	R-HSA-5621480	9.999392e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.999463e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999500e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999529e-01	0.000
Sialic acid metabolism	R-HSA-4085001	9.999549e-01	0.000
Glutathione conjugation	R-HSA-156590	9.999612e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999617e-01	0.000
Translation	R-HSA-72766	9.999636e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999636e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999683e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999699e-01	0.000
Digestion and absorption	R-HSA-8963743	9.999752e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999786e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.999787e-01	0.000
Glycosphingolipid biosynthesis	R-HSA-9840309	9.999787e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999801e-01	0.000
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.999816e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999836e-01	0.000
SLC-mediated transport of amino acids	R-HSA-9958863	9.999864e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999890e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.999913e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.999925e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.999925e-01	0.000
Purine catabolism	R-HSA-74259	9.999936e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999945e-01	0.000
Aspirin ADME	R-HSA-9749641	9.999945e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999948e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999948e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999963e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999973e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999978e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999981e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999981e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999982e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.999983e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999983e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999983e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999986e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999988e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999989e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999992e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999993e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999993e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999994e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999995e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999997e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999998e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999999e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000e+00	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	1.000000e+00	0.000
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Post-translational protein modification	R-HSA-597592	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955
Axon guidance	R-HSA-422475	1.110223e-16	15.955
Nervous system development	R-HSA-9675108	1.110223e-16	15.955
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.332268e-15	14.875
Cell Cycle, Mitotic	R-HSA-69278	8.215650e-15	14.085
Cellular response to heat stress	R-HSA-3371556	1.010303e-14	13.996
Metabolism of RNA	R-HSA-8953854	4.137801e-13	12.383
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.965228e-13	12.224
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	8.327783e-13	12.079
Eukaryotic Translation Initiation	R-HSA-72613	9.982015e-13	12.001
Cap-dependent Translation Initiation	R-HSA-72737	9.982015e-13	12.001
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.016387e-12	11.695
M Phase	R-HSA-68886	3.472778e-12	11.459
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	5.015321e-12	11.300
Signaling by ALK in cancer	R-HSA-9700206	5.015321e-12	11.300
Signaling by ROBO receptors	R-HSA-376176	4.770073e-12	11.321
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.755129e-11	10.756
HSF1-dependent transactivation	R-HSA-3371571	3.355893e-11	10.474
Cytokine Signaling in Immune system	R-HSA-1280215	3.668721e-11	10.435
Attenuation phase	R-HSA-3371568	6.981726e-11	10.156
Cell-Cell communication	R-HSA-1500931	1.051178e-10	9.978
Formation of a pool of free 40S subunits	R-HSA-72689	1.535830e-10	9.814
Eukaryotic Translation Elongation	R-HSA-156842	1.609008e-10	9.793
Cell Cycle Checkpoints	R-HSA-69620	2.159686e-10	9.666
HSF1 activation	R-HSA-3371511	2.408654e-10	9.618
Apoptotic execution phase	R-HSA-75153	3.409727e-10	9.467
EPH-Ephrin signaling	R-HSA-2682334	5.262670e-10	9.279
G2/M Checkpoints	R-HSA-69481	6.061655e-10	9.217
Programmed Cell Death	R-HSA-5357801	1.948605e-09	8.710
Ribosome-associated quality control	R-HSA-9948299	3.725344e-09	8.429
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.031057e-09	8.395
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	3.882200e-09	8.411
Peptide chain elongation	R-HSA-156902	4.349962e-09	8.362
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	5.095294e-09	8.293
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	5.356283e-09	8.271
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.607763e-09	8.251
rRNA processing in the nucleus and cytosol	R-HSA-8868773	6.681450e-09	8.175
Translation initiation complex formation	R-HSA-72649	7.056207e-09	8.151
G2/M DNA damage checkpoint	R-HSA-69473	7.192526e-09	8.143
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	7.366977e-09	8.133
Influenza Infection	R-HSA-168255	7.999926e-09	8.097
Post NMDA receptor activation events	R-HSA-438064	1.042974e-08	7.982
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.078716e-08	7.967
Apoptosis	R-HSA-109581	1.117830e-08	7.952
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.122302e-08	7.950
Mitotic Anaphase	R-HSA-68882	1.170934e-08	7.931
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.194820e-08	7.923
Ribosomal scanning and start codon recognition	R-HSA-72702	1.388349e-08	7.858
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.426680e-08	7.846
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.426680e-08	7.846
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.368236e-08	7.864
Signaling by VEGF	R-HSA-194138	2.203748e-08	7.657
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.893013e-08	7.539
Recycling pathway of L1	R-HSA-437239	3.364211e-08	7.473
Interferon Signaling	R-HSA-913531	3.866663e-08	7.413
Interleukin-12 signaling	R-HSA-9020591	4.106528e-08	7.387
Viral Infection Pathways	R-HSA-9824446	4.354102e-08	7.361
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.601060e-08	7.337
Signaling by ERBB2	R-HSA-1227986	4.946351e-08	7.306
L1CAM interactions	R-HSA-373760	5.208598e-08	7.283
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	6.188762e-08	7.208
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	6.452899e-08	7.190
SARS-CoV-1-host interactions	R-HSA-9692914	8.015857e-08	7.096
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	8.985697e-08	7.046
Interleukin-12 family signaling	R-HSA-447115	9.520241e-08	7.021
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.143996e-07	6.942
Eukaryotic Translation Termination	R-HSA-72764	1.198180e-07	6.921
SARS-CoV-2-host interactions	R-HSA-9705683	1.496059e-07	6.825
Cell junction organization	R-HSA-446728	1.666541e-07	6.778
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.674366e-07	6.776
Separation of Sister Chromatids	R-HSA-2467813	2.124216e-07	6.673
Signal Transduction	R-HSA-162582	3.024499e-07	6.519
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.304078e-07	6.481
Mitotic Prometaphase	R-HSA-68877	3.891811e-07	6.410
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.420927e-07	6.266
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	6.938738e-07	6.159
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	8.985343e-07	6.046
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	8.995482e-07	6.046
mRNA Splicing	R-HSA-72172	9.911278e-07	6.004
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.002432e-06	5.999
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.002432e-06	5.999
PKR-mediated signaling	R-HSA-9833482	1.008249e-06	5.996
Selenocysteine synthesis	R-HSA-2408557	1.159903e-06	5.936
Signaling by Interleukins	R-HSA-449147	1.224597e-06	5.912
Cellular Senescence	R-HSA-2559583	1.283559e-06	5.892
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.606528e-06	5.794
Viral mRNA Translation	R-HSA-192823	1.718036e-06	5.765
Mitotic Prophase	R-HSA-68875	1.826140e-06	5.738
Downregulation of ERBB2 signaling	R-HSA-8863795	1.901202e-06	5.721
mRNA Splicing - Major Pathway	R-HSA-72163	2.018692e-06	5.695
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	2.043791e-06	5.690
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.113745e-06	5.675
rRNA processing	R-HSA-72312	2.160440e-06	5.665
Intracellular signaling by second messengers	R-HSA-9006925	2.454337e-06	5.610
ISG15 antiviral mechanism	R-HSA-1169408	2.583377e-06	5.588
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.762638e-06	5.559
Meiotic synapsis	R-HSA-1221632	2.642041e-06	5.578
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.882227e-06	5.540
Ephrin signaling	R-HSA-3928664	2.902352e-06	5.537
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.929162e-06	5.533
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	3.121836e-06	5.506
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.363698e-06	5.473
Processing of DNA double-strand break ends	R-HSA-5693607	3.513887e-06	5.454
Regulation of endogenous retroelements	R-HSA-9842860	3.588905e-06	5.445
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.096659e-06	5.388
Chromatin organization	R-HSA-4839726	4.281394e-06	5.368
SARS-CoV Infections	R-HSA-9679506	4.666617e-06	5.331
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.238222e-06	5.281
Aggrephagy	R-HSA-9646399	5.703056e-06	5.244
Developmental Biology	R-HSA-1266738	5.565021e-06	5.255
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	5.394537e-06	5.268
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	5.968733e-06	5.224
SARS-CoV-1 Infection	R-HSA-9678108	6.038172e-06	5.219
Host Interactions of HIV factors	R-HSA-162909	8.396463e-06	5.076
HIV Infection	R-HSA-162906	8.878880e-06	5.052
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.011804e-05	4.995
Cell-cell junction organization	R-HSA-421270	1.015708e-05	4.993
Transcriptional regulation by small RNAs	R-HSA-5578749	1.028850e-05	4.988
S Phase	R-HSA-69242	1.095641e-05	4.960
Adherens junctions interactions	R-HSA-418990	1.160963e-05	4.935
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.183266e-05	4.927
Transcriptional Regulation by MECP2	R-HSA-8986944	1.232147e-05	4.909
G2/M Transition	R-HSA-69275	1.240956e-05	4.906
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.372371e-05	4.863
ESR-mediated signaling	R-HSA-8939211	1.445392e-05	4.840
Transcriptional regulation by RUNX1	R-HSA-8878171	1.516022e-05	4.819
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.539720e-05	4.813
Deubiquitination	R-HSA-5688426	1.562809e-05	4.806
Mitotic G2-G2/M phases	R-HSA-453274	1.593000e-05	4.798
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.825683e-05	4.739
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.879877e-05	4.726
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.954682e-05	4.709
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	2.018100e-05	4.695
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.032413e-05	4.692
Meiosis	R-HSA-1500620	2.079615e-05	4.682
Regulation of CDH1 Function	R-HSA-9764561	2.202377e-05	4.657
SARS-CoV-2 Infection	R-HSA-9694516	2.556447e-05	4.592
DNA Double Strand Break Response	R-HSA-5693606	2.615744e-05	4.582
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.747626e-05	4.561
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.769524e-05	4.558
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	3.140023e-05	4.503
Regulation of T cell activation by CD28 family	R-HSA-388841	3.173389e-05	4.498
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.276059e-05	4.485
Nephrin family interactions	R-HSA-373753	3.276059e-05	4.485
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.328020e-05	4.478
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.357268e-05	4.474
Chromatin modifying enzymes	R-HSA-3247509	3.629963e-05	4.440
RNA Polymerase I Transcription	R-HSA-73864	3.509458e-05	4.455
MAPK family signaling cascades	R-HSA-5683057	3.645404e-05	4.438
Homology Directed Repair	R-HSA-5693538	3.746687e-05	4.426
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.801052e-05	4.420
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	3.801052e-05	4.420
Signaling by Hippo	R-HSA-2028269	4.143832e-05	4.383
DNA Double-Strand Break Repair	R-HSA-5693532	4.511411e-05	4.346
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.070162e-05	4.295
Assembly of the pre-replicative complex	R-HSA-68867	5.144723e-05	4.289
Membrane Trafficking	R-HSA-199991	5.386631e-05	4.269
Regulation of TP53 Activity	R-HSA-5633007	5.442599e-05	4.264
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.689458e-05	4.245
Cohesin Loading onto Chromatin	R-HSA-2470946	6.012326e-05	4.221
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.077445e-05	4.216
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	6.367122e-05	4.196
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	6.738264e-05	4.171
Regulation of TP53 Degradation	R-HSA-6804757	6.738264e-05	4.171
Transcriptional Regulation by TP53	R-HSA-3700989	6.544334e-05	4.184
Regulation of MECP2 expression and activity	R-HSA-9022692	7.152891e-05	4.146
Developmental Lineages of the Mammary Gland	R-HSA-9924644	7.189081e-05	4.143
EPHB-mediated forward signaling	R-HSA-3928662	7.261583e-05	4.139
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	7.388273e-05	4.131
ATP-dependent chromatin remodelers	R-HSA-9932444	7.396064e-05	4.131
SWI/SNF chromatin remodelers	R-HSA-9932451	7.396064e-05	4.131
Estrogen-dependent gene expression	R-HSA-9018519	7.529285e-05	4.123
Mitotic G1 phase and G1/S transition	R-HSA-453279	7.557718e-05	4.122
Signaling by PTK6	R-HSA-8848021	8.161553e-05	4.088
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	8.161553e-05	4.088
Semaphorin interactions	R-HSA-373755	8.161553e-05	4.088
PI3K/AKT Signaling in Cancer	R-HSA-2219528	8.172346e-05	4.088
Cellular response to starvation	R-HSA-9711097	8.457477e-05	4.073
Gene expression (Transcription)	R-HSA-74160	8.541294e-05	4.068
Striated Muscle Contraction	R-HSA-390522	9.530615e-05	4.021
Regulation of signaling by CBL	R-HSA-912631	9.331546e-05	4.030
Signaling by RAF1 mutants	R-HSA-9656223	1.038843e-04	3.983
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.050679e-04	3.979
HDACs deacetylate histones	R-HSA-3214815	1.108607e-04	3.955
Kinesins	R-HSA-983189	1.171541e-04	3.931
Signaling by RAS mutants	R-HSA-6802949	1.172337e-04	3.931
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.172337e-04	3.931
Signaling downstream of RAS mutants	R-HSA-9649948	1.172337e-04	3.931
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.172337e-04	3.931
PIP3 activates AKT signaling	R-HSA-1257604	1.314532e-04	3.881
EPHA-mediated growth cone collapse	R-HSA-3928663	1.403986e-04	3.853
Ub-specific processing proteases	R-HSA-5689880	1.466373e-04	3.834
HIV Life Cycle	R-HSA-162587	1.471738e-04	3.832
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.486645e-04	3.828
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.593486e-04	3.798
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.680662e-04	3.775
DNA Replication Pre-Initiation	R-HSA-69002	1.680662e-04	3.775
Nuclear Envelope Breakdown	R-HSA-2980766	1.682894e-04	3.774
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.896920e-04	3.722
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.968711e-04	3.706
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.955706e-04	3.709
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.839547e-04	3.735
Glycolysis	R-HSA-70171	1.842820e-04	3.735
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.799286e-04	3.745
Nef and signal transduction	R-HSA-164944	2.038548e-04	3.691
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.147878e-04	3.668
Cell-extracellular matrix interactions	R-HSA-446353	2.336182e-04	3.631
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.336182e-04	3.631
MAPK1/MAPK3 signaling	R-HSA-5684996	2.399955e-04	3.620
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.400717e-04	3.620
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.419604e-04	3.616
FLT3 Signaling	R-HSA-9607240	2.419604e-04	3.616
Oxidative Stress Induced Senescence	R-HSA-2559580	2.472754e-04	3.607
Chaperone Mediated Autophagy	R-HSA-9613829	2.615024e-04	3.583
Transport of connexons to the plasma membrane	R-HSA-190872	2.615024e-04	3.583
Nucleosome assembly	R-HSA-774815	2.654550e-04	3.576
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.654550e-04	3.576
Oncogenic MAPK signaling	R-HSA-6802957	2.900129e-04	3.538
Protein ubiquitination	R-HSA-8852135	3.034591e-04	3.518
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.108934e-04	3.507
Josephin domain DUBs	R-HSA-5689877	3.503381e-04	3.456
NoRC negatively regulates rRNA expression	R-HSA-427413	3.647620e-04	3.438
RAF/MAP kinase cascade	R-HSA-5673001	3.705589e-04	3.431
TCR signaling	R-HSA-202403	4.075576e-04	3.390
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	4.322405e-04	3.364
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.525440e-04	3.344
RNA Polymerase I Promoter Opening	R-HSA-73728	4.763355e-04	3.322
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.398394e-04	3.357
Nuclear Receptor transcription pathway	R-HSA-383280	4.967461e-04	3.304
Cellular response to chemical stress	R-HSA-9711123	4.979619e-04	3.303
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.852428e-04	3.314
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	5.067515e-04	3.295
RNA Polymerase II Transcription	R-HSA-73857	5.113565e-04	3.291
KEAP1-NFE2L2 pathway	R-HSA-9755511	5.196479e-04	3.284
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	5.200219e-04	3.284
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	5.203399e-04	3.284
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.250196e-04	3.280
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.516907e-04	3.258
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	5.598759e-04	3.252
Gene Silencing by RNA	R-HSA-211000	5.658692e-04	3.247
Gap junction trafficking	R-HSA-190828	5.884889e-04	3.230
Selenoamino acid metabolism	R-HSA-2408522	6.031029e-04	3.220
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.127318e-04	3.213
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.127318e-04	3.213
Gap junction trafficking and regulation	R-HSA-157858	6.127318e-04	3.213
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	6.200711e-04	3.208
PRC2 methylates histones and DNA	R-HSA-212300	6.344896e-04	3.198
GPVI-mediated activation cascade	R-HSA-114604	6.344896e-04	3.198
Immune System	R-HSA-168256	6.548663e-04	3.184
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.661828e-04	3.176
Downregulation of ERBB4 signaling	R-HSA-1253288	6.661828e-04	3.176
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	6.661828e-04	3.176
Late Phase of HIV Life Cycle	R-HSA-162599	6.847759e-04	3.164
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	7.223922e-04	3.141
Transport of the SLBP independent Mature mRNA	R-HSA-159227	7.223922e-04	3.141
Assembly of the ORC complex at the origin of replication	R-HSA-68616	7.223922e-04	3.141
Cyclin E associated events during G1/S transition	R-HSA-69202	7.259702e-04	3.139
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	7.968829e-04	3.099
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.968829e-04	3.099
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.116339e-04	3.091
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	9.641282e-04	3.016
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.641282e-04	3.016
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	9.641282e-04	3.016
Long-term potentiation	R-HSA-9620244	8.957140e-04	3.048
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	9.165293e-04	3.038
HCMV Early Events	R-HSA-9609690	8.395329e-04	3.076
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.804477e-04	3.055
G1/S Transition	R-HSA-69206	9.493201e-04	3.023
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	9.167084e-04	3.038
Hedgehog 'off' state	R-HSA-5610787	8.381217e-04	3.077
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	9.827413e-04	3.008
Translation	R-HSA-72766	1.001859e-03	2.999
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.042569e-03	2.982
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.044147e-03	2.981
RNA Polymerase I Promoter Escape	R-HSA-73772	1.082580e-03	2.966
Nuclear import of Rev protein	R-HSA-180746	1.152828e-03	2.938
Diseases of programmed cell death	R-HSA-9645723	1.155368e-03	2.937
Epigenetic regulation of gene expression	R-HSA-212165	1.166279e-03	2.933
Co-inhibition by PD-1	R-HSA-389948	1.204185e-03	2.919
Golgi-to-ER retrograde transport	R-HSA-8856688	1.222840e-03	2.913
Defective pyroptosis	R-HSA-9710421	1.274910e-03	2.895
Co-stimulation by CD28	R-HSA-389356	1.295616e-03	2.888
Smooth Muscle Contraction	R-HSA-445355	1.295629e-03	2.888
Pervasive developmental disorders	R-HSA-9005895	1.320034e-03	2.879
Disorders of Nervous System Development	R-HSA-9697154	1.320034e-03	2.879
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.320034e-03	2.879
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.320034e-03	2.879
Generic Transcription Pathway	R-HSA-212436	1.322857e-03	2.878
Response of endothelial cells to shear stress	R-HSA-9860931	1.396874e-03	2.855
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.461986e-03	2.835
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.489952e-03	2.827
Packaging Of Telomere Ends	R-HSA-171306	1.506706e-03	2.822
Interactions of Rev with host cellular proteins	R-HSA-177243	1.509893e-03	2.821
Potential therapeutics for SARS	R-HSA-9679191	1.579952e-03	2.801
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.648131e-03	2.783
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.670727e-03	2.777
Folding of actin by CCT/TriC	R-HSA-390450	1.722230e-03	2.764
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.953423e-03	2.709
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.953423e-03	2.709
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.953423e-03	2.709
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.953423e-03	2.709
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.953423e-03	2.709
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.953423e-03	2.709
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.953423e-03	2.709
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.953423e-03	2.709
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.953423e-03	2.709
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.953423e-03	2.709
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.953423e-03	2.709
Regulation of PTEN localization	R-HSA-8948747	2.131520e-03	2.671
Disorders of Developmental Biology	R-HSA-9675151	1.931896e-03	2.714
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.180787e-03	2.661
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.187074e-03	2.660
DNA Replication	R-HSA-69306	2.115645e-03	2.675
Muscle contraction	R-HSA-397014	2.153958e-03	2.667
MAP2K and MAPK activation	R-HSA-5674135	2.234706e-03	2.651
Degradation of GLI1 by the proteasome	R-HSA-5610780	2.234706e-03	2.651
Condensation of Prophase Chromosomes	R-HSA-2299718	2.239984e-03	2.650
TCF dependent signaling in response to WNT	R-HSA-201681	2.282615e-03	2.642
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	2.363821e-03	2.626
Glucose metabolism	R-HSA-70326	2.383710e-03	2.623
DNA methylation	R-HSA-5334118	2.426274e-03	2.615
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.427248e-03	2.615
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.427248e-03	2.615
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.583780e-03	2.588
PECAM1 interactions	R-HSA-210990	2.593396e-03	2.586
Cellular responses to mechanical stimuli	R-HSA-9855142	2.596545e-03	2.586
Orc1 removal from chromatin	R-HSA-68949	2.618454e-03	2.582
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.667946e-03	2.574
G1/S DNA Damage Checkpoints	R-HSA-69615	2.840146e-03	2.547
MAPK6/MAPK4 signaling	R-HSA-5687128	2.930166e-03	2.533
HATs acetylate histones	R-HSA-3214847	2.975323e-03	2.526
Signaling by ERBB2 in Cancer	R-HSA-1227990	3.033703e-03	2.518
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.033703e-03	2.518
Regulation of PTEN stability and activity	R-HSA-8948751	3.084797e-03	2.511
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.173611e-03	2.498
RAF activation	R-HSA-5673000	3.174135e-03	2.498
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	3.174135e-03	2.498
Signaling by SCF-KIT	R-HSA-1433557	3.227110e-03	2.491
Transcriptional Regulation by E2F6	R-HSA-8953750	3.232489e-03	2.490
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.232489e-03	2.490
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.371011e-03	2.472
Neutrophil degranulation	R-HSA-6798695	3.402224e-03	2.468
snRNP Assembly	R-HSA-191859	3.463147e-03	2.461
Metabolism of non-coding RNA	R-HSA-194441	3.463147e-03	2.461
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	3.516740e-03	2.454
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.617961e-03	2.442
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.636335e-03	2.439
Sema3A PAK dependent Axon repulsion	R-HSA-399954	3.742592e-03	2.427
Degradation of CDH1	R-HSA-9766229	3.748933e-03	2.426
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	3.758755e-03	2.425
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	3.758755e-03	2.425
Evasion by RSV of host interferon responses	R-HSA-9833109	3.758755e-03	2.425
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	3.768845e-03	2.424
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	3.769674e-03	2.424
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	3.844785e-03	2.415
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	3.869820e-03	2.412
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.891112e-03	2.410
Generation of second messenger molecules	R-HSA-202433	3.891112e-03	2.410
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.891112e-03	2.410
mTORC1-mediated signalling	R-HSA-166208	4.063171e-03	2.391
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	4.074601e-03	2.390
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	4.311497e-03	2.365
AKT phosphorylates targets in the nucleus	R-HSA-198693	5.137226e-03	2.289
ALK mutants bind TKIs	R-HSA-9700645	5.137226e-03	2.289
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	4.654884e-03	2.332
PTEN Regulation	R-HSA-6807070	4.910274e-03	2.309
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.555836e-03	2.341
CaM pathway	R-HSA-111997	4.683935e-03	2.329
Calmodulin induced events	R-HSA-111933	4.683935e-03	2.329
DAG and IP3 signaling	R-HSA-1489509	4.555836e-03	2.341
RET signaling	R-HSA-8853659	4.683935e-03	2.329
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	5.137226e-03	2.289
Meiotic recombination	R-HSA-912446	5.157082e-03	2.288
Platelet activation, signaling and aggregation	R-HSA-76002	4.945833e-03	2.306
Rap1 signalling	R-HSA-392517	4.592636e-03	2.338
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	4.224944e-03	2.374
Selective autophagy	R-HSA-9663891	4.801766e-03	2.319
MHC class II antigen presentation	R-HSA-2132295	4.447924e-03	2.352
DNA Repair	R-HSA-73894	5.305817e-03	2.275
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	5.310318e-03	2.275
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.310318e-03	2.275
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	5.535500e-03	2.257
Degradation of GLI2 by the proteasome	R-HSA-5610783	5.535500e-03	2.257
Negative regulation of MAPK pathway	R-HSA-5675221	5.535500e-03	2.257
HCMV Infection	R-HSA-9609646	5.542535e-03	2.256
IPs transport between nucleus and cytosol	R-HSA-1855170	5.625288e-03	2.250
Regulation of necroptotic cell death	R-HSA-5675482	5.625288e-03	2.250
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	5.625288e-03	2.250
Cleavage of the damaged purine	R-HSA-110331	5.630329e-03	2.249
Negative regulation of MET activity	R-HSA-6807004	5.931661e-03	2.227
Co-inhibition by CTLA4	R-HSA-389513	5.931661e-03	2.227
Signal transduction by L1	R-HSA-445144	5.931661e-03	2.227
Reproduction	R-HSA-1474165	5.939730e-03	2.226
mRNA 3'-end processing	R-HSA-72187	6.007453e-03	2.221
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	6.155249e-03	2.211
Loss of Nlp from mitotic centrosomes	R-HSA-380259	6.155249e-03	2.211
Infectious disease	R-HSA-5663205	6.199967e-03	2.208
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	6.467065e-03	2.189
CD209 (DC-SIGN) signaling	R-HSA-5621575	6.467065e-03	2.189
MTOR signalling	R-HSA-165159	6.545235e-03	2.184
Ca-dependent events	R-HSA-111996	6.545235e-03	2.184
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	6.684432e-03	2.175
Depurination	R-HSA-73927	6.723537e-03	2.172
Signaling by ERBB2 KD Mutants	R-HSA-9664565	6.733829e-03	2.172
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	6.740558e-03	2.171
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	6.800758e-03	2.167
Apoptosis induced DNA fragmentation	R-HSA-140342	7.464189e-03	2.127
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.464189e-03	2.127
Clathrin-mediated endocytosis	R-HSA-8856828	7.630803e-03	2.117
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	7.700305e-03	2.113
COPI-mediated anterograde transport	R-HSA-6807878	7.710343e-03	2.113
Stabilization of p53	R-HSA-69541	7.978700e-03	2.098
Sema4D in semaphorin signaling	R-HSA-400685	8.022961e-03	2.096
Interleukin-7 signaling	R-HSA-1266695	8.022961e-03	2.096
Autophagy	R-HSA-9612973	8.054143e-03	2.094
FLT3 signaling through SRC family kinases	R-HSA-9706374	8.086419e-03	2.092
AKT-mediated inactivation of FOXO1A	R-HSA-211163	8.086419e-03	2.092
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	8.161621e-03	2.088
Gap junction assembly	R-HSA-190861	8.161621e-03	2.088
DAP12 signaling	R-HSA-2424491	8.197798e-03	2.086
Activation of BH3-only proteins	R-HSA-114452	8.197798e-03	2.086
Protein folding	R-HSA-391251	8.442077e-03	2.074
Signaling by TGF-beta Receptor Complex	R-HSA-170834	8.562502e-03	2.067
Cyclin D associated events in G1	R-HSA-69231	9.003721e-03	2.046
G1 Phase	R-HSA-69236	9.003721e-03	2.046
AURKA Activation by TPX2	R-HSA-8854518	9.131443e-03	2.039
Glycogen metabolism	R-HSA-8982491	9.411474e-03	2.026
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.411474e-03	2.026
MITF-M-regulated melanocyte development	R-HSA-9730414	9.451422e-03	2.025
Signaling by PDGFR in disease	R-HSA-9671555	9.492235e-03	2.023
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	9.492235e-03	2.023
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	9.492235e-03	2.023
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	9.492235e-03	2.023
Transcriptional regulation by RUNX2	R-HSA-8878166	9.522838e-03	2.021
Signaling by WNT	R-HSA-195721	9.686116e-03	2.014
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	9.726580e-03	2.012
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	9.749051e-03	2.011
Signaling by EGFR in Cancer	R-HSA-1643713	9.851929e-03	2.006
PLC beta mediated events	R-HSA-112043	9.856336e-03	2.006
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.897315e-03	2.004
Macroautophagy	R-HSA-1632852	9.952134e-03	2.002
Signaling by NOTCH	R-HSA-157118	1.021829e-02	1.991
Interleukin-2 signaling	R-HSA-9020558	1.046918e-02	1.980
p75 NTR receptor-mediated signalling	R-HSA-193704	1.049736e-02	1.979
FLT3 signaling by CBL mutants	R-HSA-9706377	1.355697e-02	1.868
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.277608e-02	1.894
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	1.277608e-02	1.894
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.110982e-02	1.954
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.409580e-02	1.851
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.354565e-02	1.868
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	1.304219e-02	1.885
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.074002e-02	1.969
Centrosome maturation	R-HSA-380287	1.351483e-02	1.869
Ovarian tumor domain proteases	R-HSA-5689896	1.354565e-02	1.868
Chromosome Maintenance	R-HSA-73886	1.139940e-02	1.943
Signaling by EGFR	R-HSA-177929	1.060745e-02	1.974
Integrin signaling	R-HSA-354192	1.409580e-02	1.851
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	1.178537e-02	1.929
Protein methylation	R-HSA-8876725	1.277608e-02	1.894
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.198248e-02	1.921
Translesion Synthesis by POLH	R-HSA-110320	1.399650e-02	1.854
Extra-nuclear estrogen signaling	R-HSA-9009391	1.277131e-02	1.894
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.103793e-02	1.957
Switching of origins to a post-replicative state	R-HSA-69052	1.074002e-02	1.969
Degradation of DVL	R-HSA-4641258	1.354565e-02	1.868
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.110982e-02	1.954
Signaling by NTRKs	R-HSA-166520	1.150022e-02	1.939
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.198248e-02	1.921
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.356538e-02	1.868
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.354565e-02	1.868
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.185552e-02	1.926
tRNA processing in the nucleus	R-HSA-6784531	1.120668e-02	1.951
Signaling by Hedgehog	R-HSA-5358351	1.293317e-02	1.888
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.213784e-02	1.916
Signaling by KIT in disease	R-HSA-9669938	1.178537e-02	1.929
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.110982e-02	1.954
Vesicle-mediated transport	R-HSA-5653656	1.417129e-02	1.849
Reduction of cytosolic Ca++ levels	R-HSA-418359	1.424485e-02	1.846
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.446847e-02	1.840
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.489517e-02	1.827
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.493762e-02	1.826
Cleavage of the damaged pyrimidine	R-HSA-110329	1.493762e-02	1.826
Depyrimidination	R-HSA-73928	1.493762e-02	1.826
ROBO receptors bind AKAP5	R-HSA-9010642	1.494467e-02	1.826
Myoclonic epilepsy of Lafora	R-HSA-3785653	1.494467e-02	1.826
Formation of annular gap junctions	R-HSA-196025	1.494467e-02	1.826
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.494467e-02	1.826
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.583875e-02	1.800
Cilium Assembly	R-HSA-5617833	1.636627e-02	1.786
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.654984e-02	1.781
Late endosomal microautophagy	R-HSA-9615710	1.726282e-02	1.763
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.739412e-02	1.760
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.757710e-02	1.755
Neurodegenerative Diseases	R-HSA-8863678	1.757710e-02	1.755
Signaling by Nuclear Receptors	R-HSA-9006931	1.770693e-02	1.752
TP53 Regulates Metabolic Genes	R-HSA-5628897	1.802133e-02	1.744
Death Receptor Signaling	R-HSA-73887	1.811635e-02	1.742
DNA Damage Bypass	R-HSA-73893	1.835237e-02	1.736
FOXO-mediated transcription	R-HSA-9614085	1.866894e-02	1.729
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.870316e-02	1.728
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	1.878782e-02	1.726
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.887740e-02	1.724
Signaling by LTK	R-HSA-9842663	1.887740e-02	1.724
VLDLR internalisation and degradation	R-HSA-8866427	1.887740e-02	1.724
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.920453e-02	1.717
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.951588e-02	1.710
Dual Incision in GG-NER	R-HSA-5696400	1.951588e-02	1.710
Interferon alpha/beta signaling	R-HSA-909733	1.960271e-02	1.708
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.981029e-02	1.703
RNA Polymerase II Transcription Termination	R-HSA-73856	1.983807e-02	1.703
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.983807e-02	1.703
G-protein mediated events	R-HSA-112040	2.028628e-02	1.693
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	2.057803e-02	1.687
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.074457e-02	1.683
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	2.075707e-02	1.683
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.083114e-02	1.681
Gap junction degradation	R-HSA-190873	2.083114e-02	1.681
Calcineurin activates NFAT	R-HSA-2025928	2.083114e-02	1.681
Regulation of RAS by GAPs	R-HSA-5658442	2.088468e-02	1.680
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.093970e-02	1.679
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	2.093970e-02	1.679
Maturation of protein E	R-HSA-9694493	2.093970e-02	1.679
Maturation of protein E	R-HSA-9683683	2.093970e-02	1.679
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.128940e-02	1.672
MITF-M-dependent gene expression	R-HSA-9856651	2.149140e-02	1.668
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.168593e-02	1.664
Ion homeostasis	R-HSA-5578775	2.168593e-02	1.664
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.168593e-02	1.664
Organelle biogenesis and maintenance	R-HSA-1852241	2.192711e-02	1.659
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.210408e-02	1.656
Regulated Necrosis	R-HSA-5218859	2.263643e-02	1.645
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.265273e-02	1.645
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	2.274151e-02	1.643
Regulation of Apoptosis	R-HSA-169911	2.274151e-02	1.643
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.291208e-02	1.640
Amplification of signal from the kinetochores	R-HSA-141424	2.291208e-02	1.640
Adaptive Immune System	R-HSA-1280218	2.341508e-02	1.631
Trafficking of AMPA receptors	R-HSA-399719	2.408903e-02	1.618
EGFR downregulation	R-HSA-182971	2.408903e-02	1.618
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.408903e-02	1.618
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	2.408903e-02	1.618
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.444430e-02	1.612
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.444430e-02	1.612
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.444430e-02	1.612
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.448511e-02	1.611
PKMTs methylate histone lysines	R-HSA-3214841	2.448511e-02	1.611
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.448511e-02	1.611
Negative regulation of the PI3K/AKT network	R-HSA-199418	2.573528e-02	1.589
Uptake and function of anthrax toxins	R-HSA-5210891	2.582472e-02	1.588
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.589589e-02	1.587
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.589589e-02	1.587
Vif-mediated degradation of APOBEC3G	R-HSA-180585	2.634040e-02	1.579
FLT3 signaling in disease	R-HSA-9682385	2.634040e-02	1.579
Transcriptional regulation by RUNX3	R-HSA-8878159	2.697585e-02	1.569
Chaperonin-mediated protein folding	R-HSA-390466	2.765561e-02	1.558
MET interacts with TNS proteins	R-HSA-8875513	2.772721e-02	1.557
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	2.772721e-02	1.557
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.794916e-02	1.554
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	2.803416e-02	1.552
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	2.805360e-02	1.552
G0 and Early G1	R-HSA-1538133	2.814863e-02	1.551
Opioid Signalling	R-HSA-111885	2.885931e-02	1.540
Signaling by NTRK2 (TRKB)	R-HSA-9006115	2.979323e-02	1.526
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	2.979323e-02	1.526
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.979323e-02	1.526
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.033353e-02	1.518
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	3.101226e-02	1.508
Regulation of KIT signaling	R-HSA-1433559	3.101226e-02	1.508
Regulation of IFNA/IFNB signaling	R-HSA-912694	3.107952e-02	1.508
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	3.107952e-02	1.508
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.167734e-02	1.499
Activation of ATR in response to replication stress	R-HSA-176187	3.267217e-02	1.486
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.267217e-02	1.486
Base-Excision Repair, AP Site Formation	R-HSA-73929	3.369085e-02	1.472
Mitotic Spindle Checkpoint	R-HSA-69618	3.471739e-02	1.459
Disease	R-HSA-1643685	3.589184e-02	1.445
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.617037e-02	1.442
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.669120e-02	1.435
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.693175e-02	1.433
Developmental Cell Lineages	R-HSA-9734767	3.716585e-02	1.430
Signaling by NOTCH3	R-HSA-9012852	3.762752e-02	1.424
Vpu mediated degradation of CD4	R-HSA-180534	3.768213e-02	1.424
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.835685e-02	1.416
IRF3-mediated induction of type I IFN	R-HSA-3270619	3.863580e-02	1.413
Translesion synthesis by REV1	R-HSA-110312	3.863580e-02	1.413
p75NTR signals via NF-kB	R-HSA-193639	3.863580e-02	1.413
Manipulation of host energy metabolism	R-HSA-9636667	5.802264e-02	1.236
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	5.802264e-02	1.236
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.365967e-02	1.360
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	4.197311e-02	1.377
PTK6 Expression	R-HSA-8849473	4.197311e-02	1.377
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	4.197311e-02	1.377
Signaling by MRAS-complex mutants	R-HSA-9660537	5.572778e-02	1.254
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	5.572778e-02	1.254
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.679683e-02	1.330
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	4.735619e-02	1.325
Translesion synthesis by POLI	R-HSA-5656121	4.735619e-02	1.325
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.720091e-02	1.243
Translesion synthesis by POLK	R-HSA-5655862	5.720091e-02	1.243
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.432626e-02	1.265
Degradation of CRY and PER proteins	R-HSA-9932298	5.685289e-02	1.245
mRNA Splicing - Minor Pathway	R-HSA-72165	5.133829e-02	1.290
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	5.133829e-02	1.290
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	5.723116e-02	1.242
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	5.712671e-02	1.243
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.724856e-02	1.242
Telomere Maintenance	R-HSA-157579	4.518848e-02	1.345
UCH proteinases	R-HSA-5689603	4.944589e-02	1.306
Platelet calcium homeostasis	R-HSA-418360	4.064798e-02	1.391
Interleukin-2 family signaling	R-HSA-451927	4.486928e-02	1.348
Integration of provirus	R-HSA-162592	4.679683e-02	1.330
Platelet Aggregation (Plug Formation)	R-HSA-76009	4.587169e-02	1.338
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.500271e-02	1.260
Regulation of mitotic cell cycle	R-HSA-453276	5.500271e-02	1.260
DARPP-32 events	R-HSA-180024	4.064798e-02	1.391
Degradation of beta-catenin by the destruction complex	R-HSA-195253	5.027571e-02	1.299
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	5.488671e-02	1.261
Synthesis of DNA	R-HSA-69239	3.968305e-02	1.401
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.365967e-02	1.360
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.365967e-02	1.360
Budding and maturation of HIV virion	R-HSA-162588	5.390167e-02	1.268
Fanconi Anemia Pathway	R-HSA-6783310	4.587169e-02	1.338
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	4.073369e-02	1.390
Breakdown of the nuclear lamina	R-HSA-352238	5.802264e-02	1.236
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	4.924039e-02	1.308
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	5.062244e-02	1.296
Hh mutants are degraded by ERAD	R-HSA-5362768	5.062244e-02	1.296
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	4.746971e-02	1.324
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	4.190682e-02	1.378
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.626938e-02	1.335
Non-integrin membrane-ECM interactions	R-HSA-3000171	4.523443e-02	1.345
Regulation of TNFR1 signaling	R-HSA-5357905	5.133829e-02	1.290
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	3.958037e-02	1.403
NF-kB is activated and signals survival	R-HSA-209560	4.679683e-02	1.330
Regulation of RUNX3 expression and activity	R-HSA-8941858	4.486928e-02	1.348
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	4.646708e-02	1.333
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	5.698601e-02	1.244
Uptake and function of diphtheria toxin	R-HSA-5336415	4.197311e-02	1.377
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	4.319888e-02	1.365
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.720091e-02	1.243
Amyloid fiber formation	R-HSA-977225	4.449239e-02	1.352
Signaling by NOTCH4	R-HSA-9013694	4.128499e-02	1.384
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	4.587169e-02	1.338
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	4.587169e-02	1.338
Negative regulation of FLT3	R-HSA-9706369	4.735619e-02	1.325
Modulation by Mtb of host immune system	R-HSA-9637628	5.572778e-02	1.254
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.190682e-02	1.378
Regulation of IFNG signaling	R-HSA-877312	5.839703e-02	1.234
IRAK1 recruits IKK complex	R-HSA-937039	5.839703e-02	1.234
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	5.839703e-02	1.234
p75NTR recruits signalling complexes	R-HSA-209543	5.839703e-02	1.234
Downstream TCR signaling	R-HSA-202424	6.026917e-02	1.220
Diseases of mitotic cell cycle	R-HSA-9675126	6.147290e-02	1.211
Regulation of PTEN gene transcription	R-HSA-8943724	6.229212e-02	1.206
Degradation of AXIN	R-HSA-4641257	6.295653e-02	1.201
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	6.309259e-02	1.200
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	6.321998e-02	1.199
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	6.321998e-02	1.199
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	6.321998e-02	1.199
Intraflagellar transport	R-HSA-5620924	6.356001e-02	1.197
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.366043e-02	1.196
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.689681e-02	1.175
CLEC7A (Dectin-1) signaling	R-HSA-5607764	6.775737e-02	1.169
Signaling by EGFRvIII in Cancer	R-HSA-5637812	6.818339e-02	1.166
Constitutive Signaling by EGFRvIII	R-HSA-5637810	6.818339e-02	1.166
Glycogen storage diseases	R-HSA-3229121	6.818339e-02	1.166
Viral Messenger RNA Synthesis	R-HSA-168325	6.828447e-02	1.166
G-protein beta:gamma signalling	R-HSA-397795	6.968988e-02	1.157
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.968988e-02	1.157
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	6.968988e-02	1.157
Hh mutants abrogate ligand secretion	R-HSA-5387390	7.078714e-02	1.150
Hemostasis	R-HSA-109582	7.135177e-02	1.147
CD28 dependent Vav1 pathway	R-HSA-389359	7.149280e-02	1.146
Membrane binding and targetting of GAG proteins	R-HSA-174490	7.149280e-02	1.146
Platelet Adhesion to exposed collagen	R-HSA-75892	7.149280e-02	1.146
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	7.149280e-02	1.146
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.161355e-02	1.145
GP1b-IX-V activation signalling	R-HSA-430116	7.161355e-02	1.145
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.161355e-02	1.145
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.161355e-02	1.145
Cellular response to mitochondrial stress	R-HSA-9840373	7.161355e-02	1.145
Unwinding of DNA	R-HSA-176974	7.161355e-02	1.145
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	7.288283e-02	1.137
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.390953e-02	1.131
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.390953e-02	1.131
TNF signaling	R-HSA-75893	7.623101e-02	1.118
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.623101e-02	1.118
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.623101e-02	1.118
RMTs methylate histone arginines	R-HSA-3214858	7.850601e-02	1.105
DAP12 interactions	R-HSA-2172127	7.850601e-02	1.105
Signaling by ALK	R-HSA-201556	7.891943e-02	1.103
C-type lectin receptors (CLRs)	R-HSA-5621481	8.143746e-02	1.089
Interleukin receptor SHC signaling	R-HSA-912526	8.507423e-02	1.070
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.523304e-02	1.069
Hedgehog ligand biogenesis	R-HSA-5358346	8.523304e-02	1.069
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	8.588532e-02	1.066
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.606114e-02	1.065
NRIF signals cell death from the nucleus	R-HSA-205043	8.606114e-02	1.065
Signal regulatory protein family interactions	R-HSA-391160	8.606114e-02	1.065
Negative feedback regulation of MAPK pathway	R-HSA-5674499	8.611371e-02	1.065
PTK6 Regulates Cell Cycle	R-HSA-8849470	8.611371e-02	1.065
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	8.611371e-02	1.065
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	8.611371e-02	1.065
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.673214e-02	1.062
Defective CFTR causes cystic fibrosis	R-HSA-5678895	8.673214e-02	1.062
Termination of translesion DNA synthesis	R-HSA-5656169	8.737047e-02	1.059
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.737047e-02	1.059
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.808500e-02	1.055
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.808500e-02	1.055
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.808500e-02	1.055
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.954819e-02	1.048
2-LTR circle formation	R-HSA-164843	8.954819e-02	1.048
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	8.954819e-02	1.048
Interleukin-27 signaling	R-HSA-9020956	8.954819e-02	1.048
Pexophagy	R-HSA-9664873	8.954819e-02	1.048
Dual incision in TC-NER	R-HSA-6782135	9.101047e-02	1.041
ER to Golgi Anterograde Transport	R-HSA-199977	9.128682e-02	1.040
Hedgehog 'on' state	R-HSA-5632684	9.290779e-02	1.032
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.336708e-02	1.030
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.336708e-02	1.030
Uptake and actions of bacterial toxins	R-HSA-5339562	9.336708e-02	1.030
STING mediated induction of host immune responses	R-HSA-1834941	9.354668e-02	1.029
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	9.497748e-02	1.022
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	9.497748e-02	1.022
Neurophilin interactions with VEGF and VEGFR	R-HSA-194306	9.497748e-02	1.022
Base Excision Repair	R-HSA-73884	9.632089e-02	1.016
G alpha (12/13) signalling events	R-HSA-416482	9.674933e-02	1.014
Deadenylation of mRNA	R-HSA-429947	9.714675e-02	1.013
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.716954e-02	1.012
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	9.716954e-02	1.012
Signalling to ERKs	R-HSA-187687	9.826458e-02	1.008
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	9.826458e-02	1.008
Oncogene Induced Senescence	R-HSA-2559585	9.826458e-02	1.008
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	9.842923e-02	1.007
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	1.006612e-01	0.997
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.019582e-01	0.992
Erythropoietin activates RAS	R-HSA-9027284	1.020571e-01	0.991
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.020571e-01	0.991
DCC mediated attractive signaling	R-HSA-418885	1.020571e-01	0.991
Spry regulation of FGF signaling	R-HSA-1295596	1.020571e-01	0.991
Sensory processing of sound	R-HSA-9659379	1.039938e-01	0.983
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.047098e-01	0.980
Signaling by FGFR1 in disease	R-HSA-5655302	1.071512e-01	0.970
HCMV Late Events	R-HSA-9610379	1.072741e-01	0.970
Glycogen synthesis	R-HSA-3322077	1.078873e-01	0.967
Circadian clock	R-HSA-9909396	1.093037e-01	0.961
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.094101e-01	0.961
ChREBP activates metabolic gene expression	R-HSA-163765	1.094101e-01	0.961
VEGFR2 mediated cell proliferation	R-HSA-5218921	1.101111e-01	0.958
Glycogen breakdown (glycogenolysis)	R-HSA-70221	1.101111e-01	0.958
Signaling by MET	R-HSA-6806834	1.115625e-01	0.952
CREB phosphorylation	R-HSA-199920	1.119660e-01	0.951
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	1.119660e-01	0.951
Signaling by ERBB4	R-HSA-1236394	1.160729e-01	0.935
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.160729e-01	0.935
Prolonged ERK activation events	R-HSA-169893	1.194163e-01	0.923
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.194163e-01	0.923
Regulation of BACH1 activity	R-HSA-9708530	1.194163e-01	0.923
Drug resistance of PDGFR mutants	R-HSA-9674415	1.209593e-01	0.917
PDGFR mutants bind TKIs	R-HSA-9674428	1.209593e-01	0.917
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.209593e-01	0.917
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.209593e-01	0.917
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.209593e-01	0.917
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.209593e-01	0.917
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.209593e-01	0.917
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.209593e-01	0.917
DNA strand elongation	R-HSA-69190	1.227855e-01	0.911
Early Phase of HIV Life Cycle	R-HSA-162594	1.232872e-01	0.909
PKA-mediated phosphorylation of CREB	R-HSA-111931	1.232872e-01	0.909
Signaling by TGFB family members	R-HSA-9006936	1.237916e-01	0.907
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.239436e-01	0.907
Nucleotide Excision Repair	R-HSA-5696398	1.286822e-01	0.890
Signaling by FGFR4	R-HSA-5654743	1.287978e-01	0.890
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.292983e-01	0.888
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.272936e-01	0.643
Diseases of Telomere Maintenance	R-HSA-9673013	2.272936e-01	0.643
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.272936e-01	0.643
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.272936e-01	0.643
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.272936e-01	0.643
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.272936e-01	0.643
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.272936e-01	0.643
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	R-HSA-5619110	2.272936e-01	0.643
MET activates PTPN11	R-HSA-8865999	1.367762e-01	0.864
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.817076e-01	0.741
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.817076e-01	0.741
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.817076e-01	0.741
Activated NTRK2 signals through CDK5	R-HSA-9032845	1.403573e-01	0.853
NOSTRIN mediated eNOS trafficking	R-HSA-203641	1.403573e-01	0.853
IFNG signaling activates MAPKs	R-HSA-9732724	1.403573e-01	0.853
SOS-mediated signalling	R-HSA-112412	1.403573e-01	0.853
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	2.284030e-01	0.641
Activation of AKT2	R-HSA-165158	2.284030e-01	0.641
PTK6 Down-Regulation	R-HSA-8849472	2.284030e-01	0.641
IRS activation	R-HSA-74713	2.284030e-01	0.641
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.284030e-01	0.641
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.284030e-01	0.641
NTRK2 activates RAC1	R-HSA-9032759	2.284030e-01	0.641
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.708498e-01	0.767
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.708498e-01	0.767
Type I hemidesmosome assembly	R-HSA-446107	1.708498e-01	0.767
Interleukin-18 signaling	R-HSA-9012546	1.708498e-01	0.767
Activated NTRK2 signals through RAS	R-HSA-9026519	1.310466e-01	0.883
Activation of RAC1	R-HSA-428540	1.310466e-01	0.883
SHC-related events triggered by IGF1R	R-HSA-2428933	1.542815e-01	0.812
ARMS-mediated activation	R-HSA-170984	2.030076e-01	0.692
Interleukin-21 signaling	R-HSA-9020958	2.030076e-01	0.692
MASTL Facilitates Mitotic Progression	R-HSA-2465910	2.030076e-01	0.692
MAPK1 (ERK2) activation	R-HSA-112411	2.030076e-01	0.692
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.380576e-01	0.860
SHC1 events in ERBB4 signaling	R-HSA-1250347	1.380576e-01	0.860
MET activates RAP1 and RAC1	R-HSA-8875555	2.364105e-01	0.626
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	2.364105e-01	0.626
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	2.364105e-01	0.626
PI3K events in ERBB2 signaling	R-HSA-1963642	1.578858e-01	0.802
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.578858e-01	0.802
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.047684e-01	0.689
CRMPs in Sema3A signaling	R-HSA-399956	2.047684e-01	0.689
Retrograde neurotrophin signalling	R-HSA-177504	2.047684e-01	0.689
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.787944e-01	0.748
Interaction between L1 and Ankyrins	R-HSA-445095	1.386132e-01	0.858
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	2.316127e-01	0.635
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	2.316127e-01	0.635
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.006685e-01	0.698
Signaling by Erythropoietin	R-HSA-9006335	1.703076e-01	0.769
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	1.703076e-01	0.769
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.233874e-01	0.651
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.233874e-01	0.651
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.233874e-01	0.651
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.233874e-01	0.651
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.233874e-01	0.651
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.592502e-01	0.586
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.304482e-01	0.885
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.652964e-01	0.782
Formation of RNA Pol II elongation complex	R-HSA-112382	1.583369e-01	0.800
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.704712e-01	0.768
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.010967e-01	0.697
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.912309e-01	0.718
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.360475e-01	0.866
IGF1R signaling cascade	R-HSA-2428924	2.248052e-01	0.648
Downstream signal transduction	R-HSA-186763	2.048268e-01	0.689
Interleukin-9 signaling	R-HSA-8985947	1.708498e-01	0.767
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.346299e-01	0.630
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.006685e-01	0.698
Activation of the pre-replicative complex	R-HSA-68962	1.872402e-01	0.728
Signal attenuation	R-HSA-74749	2.364105e-01	0.626
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	2.556540e-01	0.592
Frs2-mediated activation	R-HSA-170968	1.789227e-01	0.747
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.382229e-01	0.623
EGFR Transactivation by Gastrin	R-HSA-2179392	2.364105e-01	0.626
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.316127e-01	0.635
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.316127e-01	0.635
Metalloprotease DUBs	R-HSA-5689901	2.346299e-01	0.630
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.061942e-01	0.686
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.300081e-01	0.886
Interleukin-15 signaling	R-HSA-8983432	1.542815e-01	0.812
HDMs demethylate histones	R-HSA-3214842	2.141752e-01	0.669
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.284030e-01	0.641
Interleukin-6 signaling	R-HSA-1059683	1.789227e-01	0.747
Regulation of CDH11 function	R-HSA-9762292	2.364105e-01	0.626
PI3K/AKT activation	R-HSA-198203	2.364105e-01	0.626
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.396976e-01	0.855
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.047684e-01	0.689
Deadenylation-dependent mRNA decay	R-HSA-429914	1.628770e-01	0.788
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.589257e-01	0.799
Myogenesis	R-HSA-525793	2.346299e-01	0.630
Interleukin-35 Signalling	R-HSA-8984722	1.542815e-01	0.812
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.817076e-01	0.741
PKA activation	R-HSA-163615	1.787944e-01	0.748
RNA Polymerase I Transcription Termination	R-HSA-73863	2.556540e-01	0.592
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.488377e-01	0.827
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.787944e-01	0.748
Activation of HOX genes during differentiation	R-HSA-5619507	1.765748e-01	0.753
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.765748e-01	0.753
RAS processing	R-HSA-9648002	2.462760e-01	0.609
Adrenoceptors	R-HSA-390696	1.708498e-01	0.767
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	1.542815e-01	0.812
Tight junction interactions	R-HSA-420029	2.141752e-01	0.669
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	1.636588e-01	0.786
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.380576e-01	0.860
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	2.006685e-01	0.698
Neurexins and neuroligins	R-HSA-6794361	2.508297e-01	0.601
Signaling by FGFR2	R-HSA-5654738	1.716329e-01	0.765
Synaptic adhesion-like molecules	R-HSA-8849932	1.787944e-01	0.748
Beta-catenin independent WNT signaling	R-HSA-3858494	1.407838e-01	0.851
CHL1 interactions	R-HSA-447041	1.403573e-01	0.853
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	2.289375e-01	0.640
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.872402e-01	0.728
Transmission across Chemical Synapses	R-HSA-112315	1.351186e-01	0.869
Signaling by FGFR3	R-HSA-5654741	1.526138e-01	0.816
Protein-protein interactions at synapses	R-HSA-6794362	1.542001e-01	0.812
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.618930e-01	0.791
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.263470e-01	0.645
FGFR1 mutant receptor activation	R-HSA-1839124	2.417315e-01	0.617
Platelet sensitization by LDL	R-HSA-432142	1.787944e-01	0.748
Rab regulation of trafficking	R-HSA-9007101	2.539753e-01	0.595
Syndecan interactions	R-HSA-3000170	1.753107e-01	0.756
Inhibition of PKR	R-HSA-169131	2.272936e-01	0.643
STAT6-mediated induction of chemokines	R-HSA-3249367	1.367762e-01	0.864
Reelin signalling pathway	R-HSA-8866376	2.284030e-01	0.641
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	2.030076e-01	0.692
MAPK3 (ERK1) activation	R-HSA-110056	2.364105e-01	0.626
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	1.326527e-01	0.877
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	2.592502e-01	0.586
Basigin interactions	R-HSA-210991	2.468267e-01	0.608
Cytoprotection by HMOX1	R-HSA-9707564	1.361991e-01	0.866
PCP/CE pathway	R-HSA-4086400	1.517884e-01	0.819
Platelet degranulation	R-HSA-114608	1.616733e-01	0.791
Cellular response to hypoxia	R-HSA-1234174	2.382229e-01	0.623
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.386369e-01	0.622
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	1.798525e-01	0.745
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	2.346299e-01	0.630
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	1.820263e-01	0.740
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.310466e-01	0.883
Activation of NF-kappaB in B cells	R-HSA-1169091	1.466543e-01	0.834
Calnexin/calreticulin cycle	R-HSA-901042	1.646129e-01	0.784
Growth hormone receptor signaling	R-HSA-982772	1.753107e-01	0.756
Gluconeogenesis	R-HSA-70263	1.921102e-01	0.716
Ion transport by P-type ATPases	R-HSA-936837	2.248052e-01	0.648
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	1.817076e-01	0.741
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	1.542815e-01	0.812
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	1.542815e-01	0.812
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	2.316127e-01	0.635
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.592502e-01	0.586
Interleukin-1 family signaling	R-HSA-446652	2.164074e-01	0.665
Assembly Of The HIV Virion	R-HSA-175474	1.396976e-01	0.855
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	2.468267e-01	0.608
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	2.468267e-01	0.608
Asymmetric localization of PCP proteins	R-HSA-4608870	1.526138e-01	0.816
NRAGE signals death through JNK	R-HSA-193648	1.304482e-01	0.885
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.468267e-01	0.608
Cation-coupled Chloride cotransporters	R-HSA-426117	1.403573e-01	0.853
NrCAM interactions	R-HSA-447038	2.284030e-01	0.641
Butyrophilin (BTN) family interactions	R-HSA-8851680	2.030076e-01	0.692
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.047684e-01	0.689
Plasma lipoprotein clearance	R-HSA-8964043	2.462760e-01	0.609
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.789227e-01	0.747
Regulation of NF-kappa B signaling	R-HSA-9758274	2.592502e-01	0.586
XBP1(S) activates chaperone genes	R-HSA-381038	2.503200e-01	0.602
Interleukin-37 signaling	R-HSA-9008059	1.872402e-01	0.728
Assembly of Viral Components at the Budding Site	R-HSA-168316	2.284030e-01	0.641
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	2.609274e-01	0.583
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.609274e-01	0.583
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	2.609274e-01	0.583
Nuclear signaling by ERBB4	R-HSA-1251985	2.640248e-01	0.578
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.640248e-01	0.578
Signaling by FGFR in disease	R-HSA-1226099	2.650683e-01	0.577
Diseases of DNA repair	R-HSA-9675135	2.657007e-01	0.576
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.666451e-01	0.574
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	2.674363e-01	0.573
Activated NTRK3 signals through RAS	R-HSA-9034864	2.706636e-01	0.568
Signaling by APC mutants	R-HSA-4839744	2.706636e-01	0.568
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.706636e-01	0.568
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.706636e-01	0.568
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.706636e-01	0.568
Ionotropic activity of kainate receptors	R-HSA-451306	2.706636e-01	0.568
Bicarbonate transporters	R-HSA-425381	2.706636e-01	0.568
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	2.706636e-01	0.568
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	2.725003e-01	0.565
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	2.725003e-01	0.565
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	2.725003e-01	0.565
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.757790e-01	0.559
Noncanonical activation of NOTCH3	R-HSA-9017802	2.757790e-01	0.559
IkBA variant leads to EDA-ID	R-HSA-5603029	2.757790e-01	0.559
Aryl hydrocarbon receptor signalling	R-HSA-8937144	2.757790e-01	0.559
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	2.757790e-01	0.559
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.757790e-01	0.559
HIV elongation arrest and recovery	R-HSA-167287	2.771612e-01	0.557
Pausing and recovery of HIV elongation	R-HSA-167290	2.771612e-01	0.557
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.771612e-01	0.557
Activation of kainate receptors upon glutamate binding	R-HSA-451326	2.771612e-01	0.557
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	2.771612e-01	0.557
Transcription of the HIV genome	R-HSA-167172	2.801717e-01	0.553
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	2.805347e-01	0.552
MAP kinase activation	R-HSA-450294	2.814145e-01	0.551
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	2.825900e-01	0.549
Unfolded Protein Response (UPR)	R-HSA-381119	2.872972e-01	0.542
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.874805e-01	0.541
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.874805e-01	0.541
Acetylcholine regulates insulin secretion	R-HSA-399997	2.874805e-01	0.541
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	2.874805e-01	0.541
ER-Phagosome pathway	R-HSA-1236974	2.876984e-01	0.541
FGFR2 alternative splicing	R-HSA-6803529	2.953642e-01	0.530
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.953642e-01	0.530
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.990646e-01	0.524
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.990646e-01	0.524
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.990646e-01	0.524
GPER1 signaling	R-HSA-9634597	2.997630e-01	0.523
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	3.005558e-01	0.522
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	3.054038e-01	0.515
Signaling by GSK3beta mutants	R-HSA-5339716	3.054038e-01	0.515
Signaling by AXIN mutants	R-HSA-4839735	3.054038e-01	0.515
Signaling by AMER1 mutants	R-HSA-4839748	3.054038e-01	0.515
Signaling by FGFR1	R-HSA-5654736	3.147613e-01	0.502
Detoxification of Reactive Oxygen Species	R-HSA-3299685	3.147613e-01	0.502
Regulation of FZD by ubiquitination	R-HSA-4641263	3.161105e-01	0.500
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	3.171790e-01	0.499
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	3.192375e-01	0.496
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	3.202144e-01	0.495
Interactions of Tat with host cellular proteins	R-HSA-176034	3.207705e-01	0.494
Beta-ketothiolase deficiency	R-HSA-9915355	3.207705e-01	0.494
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	3.207705e-01	0.494
PTEN Loss of Function in Cancer	R-HSA-5674404	3.207705e-01	0.494
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	3.207705e-01	0.494
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.207705e-01	0.494
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	3.207705e-01	0.494
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.207705e-01	0.494
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	3.207705e-01	0.494
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.207705e-01	0.494
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	3.207705e-01	0.494
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	3.207705e-01	0.494
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.229882e-01	0.491
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.229882e-01	0.491
Signaling by LTK in cancer	R-HSA-9842640	3.229882e-01	0.491
Erythropoietin activates STAT5	R-HSA-9027283	3.229882e-01	0.491
Autointegration results in viral DNA circles	R-HSA-177539	3.229882e-01	0.491
G2/M DNA replication checkpoint	R-HSA-69478	3.229882e-01	0.491
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.229882e-01	0.491
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	3.229882e-01	0.491
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.229882e-01	0.491
Integration of viral DNA into host genomic DNA	R-HSA-175567	3.229882e-01	0.491
IRE1alpha activates chaperones	R-HSA-381070	3.266909e-01	0.486
RSV-host interactions	R-HSA-9833110	3.311731e-01	0.480
Mitochondrial biogenesis	R-HSA-1592230	3.345282e-01	0.476
TBC/RABGAPs	R-HSA-8854214	3.381293e-01	0.471
Inositol phosphate metabolism	R-HSA-1483249	3.389912e-01	0.470
MET activates RAS signaling	R-HSA-8851805	3.403033e-01	0.468
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	3.403033e-01	0.468
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	3.403033e-01	0.468
Leading Strand Synthesis	R-HSA-69109	3.403033e-01	0.468
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	3.403033e-01	0.468
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	3.403033e-01	0.468
Polymerase switching	R-HSA-69091	3.403033e-01	0.468
Scavenging by Class F Receptors	R-HSA-3000484	3.403033e-01	0.468
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	3.403033e-01	0.468
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	3.403033e-01	0.468
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	3.403033e-01	0.468
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	3.403033e-01	0.468
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	3.403033e-01	0.468
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.436081e-01	0.464
GAB1 signalosome	R-HSA-180292	3.449578e-01	0.462
PKA activation in glucagon signalling	R-HSA-164378	3.449578e-01	0.462
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	3.449578e-01	0.462
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.452920e-01	0.462
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	3.452920e-01	0.462
Interferon gamma signaling	R-HSA-877300	3.505744e-01	0.455
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	3.533623e-01	0.452
Proteasome assembly	R-HSA-9907900	3.571810e-01	0.447
SLC-mediated transport of inorganic anions	R-HSA-9958790	3.617889e-01	0.442
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	3.662957e-01	0.436
MECP2 regulates transcription factors	R-HSA-9022707	3.693780e-01	0.433
MET activates PI3K/AKT signaling	R-HSA-8851907	3.693780e-01	0.433
Recycling of eIF2:GDP	R-HSA-72731	3.693780e-01	0.433
DAG1 core M1 glycosylations	R-HSA-8932506	3.693780e-01	0.433
Nef Mediated CD4 Down-regulation	R-HSA-167590	3.693780e-01	0.433
RUNX3 regulates WNT signaling	R-HSA-8951430	3.693780e-01	0.433
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.693780e-01	0.433
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	3.693780e-01	0.433
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	3.704829e-01	0.431
E2F mediated regulation of DNA replication	R-HSA-113510	3.738518e-01	0.427
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	3.738518e-01	0.427
O2/CO2 exchange in erythrocytes	R-HSA-1480926	3.738518e-01	0.427
IKK complex recruitment mediated by RIP1	R-HSA-937041	3.738518e-01	0.427
Maturation of nucleoprotein	R-HSA-9694631	3.738518e-01	0.427
Interleukin-1 signaling	R-HSA-9020702	3.744538e-01	0.427
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	3.750712e-01	0.426
Somitogenesis	R-HSA-9824272	3.763432e-01	0.424
Leishmania phagocytosis	R-HSA-9664417	3.764387e-01	0.424
FCGR3A-mediated phagocytosis	R-HSA-9664422	3.764387e-01	0.424
Parasite infection	R-HSA-9664407	3.764387e-01	0.424
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.818017e-01	0.418
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.818017e-01	0.418
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.818017e-01	0.418
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.818017e-01	0.418
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.818017e-01	0.418
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	3.824910e-01	0.417
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	3.824910e-01	0.417
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.824910e-01	0.417
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	3.875377e-01	0.412
Nuclear RNA decay	R-HSA-9930044	3.889376e-01	0.410
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.889376e-01	0.410
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.889376e-01	0.410
Negative regulation of FGFR1 signaling	R-HSA-5654726	3.889376e-01	0.410
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.927243e-01	0.406
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	3.956788e-01	0.403
Suppression of phagosomal maturation	R-HSA-9637687	3.956788e-01	0.403
Signaling by NOTCH1	R-HSA-1980143	4.003093e-01	0.398
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	4.026355e-01	0.395
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	4.029440e-01	0.395
NTF3 activates NTRK2 (TRKB) signaling	R-HSA-9025046	4.029440e-01	0.395
NTF4 activates NTRK2 (TRKB) signaling	R-HSA-9026357	4.029440e-01	0.395
BDNF activates NTRK2 (TRKB) signaling	R-HSA-9024909	4.029440e-01	0.395
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	4.029440e-01	0.395
Defective AHCY causes HMAHCHD	R-HSA-5578997	4.029440e-01	0.395
Signaling by RAS GAP mutants	R-HSA-9753510	4.029440e-01	0.395
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	4.029440e-01	0.395
Essential pentosuria	R-HSA-5662853	4.029440e-01	0.395
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	4.029440e-01	0.395
Glycogen storage disease type IV (GBE1)	R-HSA-3878781	4.029440e-01	0.395
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	4.029440e-01	0.395
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	4.029440e-01	0.395
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	4.029440e-01	0.395
Regulation of cortical dendrite branching	R-HSA-8985801	4.029440e-01	0.395
Diseases of cellular response to stress	R-HSA-9675132	4.029440e-01	0.395
Diseases of Cellular Senescence	R-HSA-9630747	4.029440e-01	0.395
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.029440e-01	0.395
HIV Transcription Elongation	R-HSA-167169	4.032260e-01	0.394
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.032260e-01	0.394
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	4.032260e-01	0.394
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	4.032260e-01	0.394
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	4.032260e-01	0.394
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	4.069931e-01	0.390
MyD88-independent TLR4 cascade	R-HSA-166166	4.069931e-01	0.390
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	4.094537e-01	0.388
Removal of the Flap Intermediate	R-HSA-69166	4.094537e-01	0.388
Signaling by FGFR4 in disease	R-HSA-5655291	4.094537e-01	0.388
HDL assembly	R-HSA-8963896	4.094537e-01	0.388
Activated NTRK2 signals through FYN	R-HSA-9032500	4.144560e-01	0.383
RSK activation	R-HSA-444257	4.144560e-01	0.383
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.144560e-01	0.383
DAG1 core M2 glycosylations	R-HSA-8932504	4.144560e-01	0.383
MET receptor recycling	R-HSA-8875656	4.144560e-01	0.383
Activated NTRK2 signals through PI3K	R-HSA-9028335	4.144560e-01	0.383
Interleukin-23 signaling	R-HSA-9020933	4.144560e-01	0.383
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.144560e-01	0.383
Co-stimulation by ICOS	R-HSA-9927354	4.144560e-01	0.383
Sodium/Proton exchangers	R-HSA-425986	4.144560e-01	0.383
Heme signaling	R-HSA-9707616	4.158141e-01	0.381
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	4.207780e-01	0.376
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	4.207780e-01	0.376
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.207780e-01	0.376
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.207780e-01	0.376
ER Quality Control Compartment (ERQC)	R-HSA-901032	4.207780e-01	0.376
Interleukin-17 signaling	R-HSA-448424	4.239535e-01	0.373
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	4.311660e-01	0.365
Lagging Strand Synthesis	R-HSA-69186	4.311660e-01	0.365
Signalling to RAS	R-HSA-167044	4.311660e-01	0.365
ERK/MAPK targets	R-HSA-198753	4.311660e-01	0.365
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.311660e-01	0.365
NGF-stimulated transcription	R-HSA-9031628	4.340157e-01	0.362
eNOS activation	R-HSA-203615	4.341054e-01	0.362
Negative regulation of FGFR2 signaling	R-HSA-5654727	4.341054e-01	0.362
Mitophagy	R-HSA-5205647	4.341054e-01	0.362
NPAS4 regulates expression of target genes	R-HSA-9768919	4.341054e-01	0.362
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	4.341054e-01	0.362
Signaling by FGFR	R-HSA-190236	4.351236e-01	0.361
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	4.376226e-01	0.359
SHC1 events in EGFR signaling	R-HSA-180336	4.432329e-01	0.353
Beta-catenin phosphorylation cascade	R-HSA-196299	4.432329e-01	0.353
Processive synthesis on the lagging strand	R-HSA-69183	4.432329e-01	0.353
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	4.432329e-01	0.353
p38MAPK events	R-HSA-171007	4.432329e-01	0.353
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	4.432329e-01	0.353
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	4.432329e-01	0.353
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	4.445669e-01	0.352
HIV Transcription Initiation	R-HSA-167161	4.445669e-01	0.352
RNA Polymerase II Transcription Initiation	R-HSA-75953	4.445669e-01	0.352
Translation of Structural Proteins	R-HSA-9683701	4.445669e-01	0.352
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.456862e-01	0.351
Phase 0 - rapid depolarisation	R-HSA-5576892	4.456862e-01	0.351
Pyroptosis	R-HSA-5620971	4.456862e-01	0.351
Insulin receptor signalling cascade	R-HSA-74751	4.498081e-01	0.347
Platelet homeostasis	R-HSA-418346	4.537539e-01	0.343
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	4.578608e-01	0.339
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	4.578608e-01	0.339
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	4.578608e-01	0.339
p75NTR regulates axonogenesis	R-HSA-193697	4.578608e-01	0.339
Regulation of CDH11 gene transcription	R-HSA-9762293	4.578608e-01	0.339
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.578608e-01	0.339
Interleukin-1 processing	R-HSA-448706	4.578608e-01	0.339
Respiratory syncytial virus genome replication	R-HSA-9834752	4.578608e-01	0.339
Signaling by NTRK3 (TRKC)	R-HSA-9034015	4.593150e-01	0.338
IRS-mediated signalling	R-HSA-112399	4.604193e-01	0.337
ABC-family proteins mediated transport	R-HSA-382556	4.625094e-01	0.335
Downstream signaling of activated FGFR3	R-HSA-5654708	4.703166e-01	0.328
PI3K Cascade	R-HSA-109704	4.721696e-01	0.326
Ca2+ pathway	R-HSA-4086398	4.722866e-01	0.326
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	4.751803e-01	0.323
Axonal growth stimulation	R-HSA-209563	4.751803e-01	0.323
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.751803e-01	0.323
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.751803e-01	0.323
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.751803e-01	0.323
Invadopodia formation	R-HSA-8941237	4.751803e-01	0.323
MET activates STAT3	R-HSA-8875791	4.751803e-01	0.323
Intracellular oxygen transport	R-HSA-8981607	4.751803e-01	0.323
CASP5-mediated substrate cleavage	R-HSA-9960525	4.751803e-01	0.323
CASP4-mediated substrate cleavage	R-HSA-9960519	4.751803e-01	0.323
Phosphorylation of the APC/C	R-HSA-176412	4.762255e-01	0.322
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	4.762255e-01	0.322
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	4.762255e-01	0.322
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	4.762255e-01	0.322
WNT5A-dependent internalization of FZD4	R-HSA-5099900	4.762255e-01	0.322
Early SARS-CoV-2 Infection Events	R-HSA-9772572	4.782379e-01	0.320
Triglyceride catabolism	R-HSA-163560	4.786570e-01	0.320
G1/S-Specific Transcription	R-HSA-69205	4.786570e-01	0.320
RNA Polymerase II Promoter Escape	R-HSA-73776	4.853828e-01	0.314
Response of Mtb to phagocytosis	R-HSA-9637690	4.853828e-01	0.314
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	4.859281e-01	0.313
Notch-HLH transcription pathway	R-HSA-350054	4.869689e-01	0.312
RAF-independent MAPK1/3 activation	R-HSA-112409	4.869689e-01	0.312
LDL clearance	R-HSA-8964038	4.869689e-01	0.312
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	4.869689e-01	0.312
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.945904e-01	0.306
Downstream signaling of activated FGFR4	R-HSA-5654716	4.945904e-01	0.306
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.945904e-01	0.306
Peroxisomal protein import	R-HSA-9033241	4.959204e-01	0.305
Binding and entry of HIV virion	R-HSA-173107	4.993377e-01	0.302
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.993377e-01	0.302
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.993377e-01	0.302
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.993377e-01	0.302
Signaling by Leptin	R-HSA-2586552	4.993377e-01	0.302
Netrin-1 signaling	R-HSA-373752	5.054732e-01	0.296
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	5.076460e-01	0.294
G beta:gamma signalling through CDC42	R-HSA-8964616	5.082802e-01	0.294
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.082802e-01	0.294
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.082802e-01	0.294
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	5.082802e-01	0.294
Transcriptional Regulation by NPAS4	R-HSA-9634815	5.097052e-01	0.293
Innate Immune System	R-HSA-168249	5.127442e-01	0.290
Sphingolipid de novo biosynthesis	R-HSA-1660661	5.134359e-01	0.290
Interleukin-20 family signaling	R-HSA-8854691	5.140285e-01	0.289
Neuronal System	R-HSA-112316	5.196668e-01	0.284
MET promotes cell motility	R-HSA-8875878	5.221034e-01	0.282
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	5.252941e-01	0.280
IRS-related events triggered by IGF1R	R-HSA-2428928	5.307554e-01	0.275
Formation of paraxial mesoderm	R-HSA-9793380	5.307554e-01	0.275
Activated NTRK2 signals through PLCG1	R-HSA-9026527	5.386806e-01	0.269
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	5.386806e-01	0.269
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	5.386806e-01	0.269
Signaling by MAP2K mutants	R-HSA-9652169	5.386806e-01	0.269
GRB7 events in ERBB2 signaling	R-HSA-1306955	5.386806e-01	0.269
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	R-HSA-2978092	5.386806e-01	0.269
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.386806e-01	0.269
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	5.386806e-01	0.269
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	5.386806e-01	0.269
Regulation of gap junction activity	R-HSA-191650	5.386806e-01	0.269
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	5.386806e-01	0.269
TNFR1-mediated ceramide production	R-HSA-5626978	5.386806e-01	0.269
NADE modulates death signalling	R-HSA-205025	5.386806e-01	0.269
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.386806e-01	0.269
Toxicity of tetanus toxin (tetX)	R-HSA-5250982	5.386806e-01	0.269
SARS-CoV-2 modulates autophagy	R-HSA-9754560	5.387178e-01	0.269
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.392752e-01	0.268
Elevation of cytosolic Ca2+ levels	R-HSA-139853	5.392752e-01	0.268
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	5.392752e-01	0.268
Interleukin-6 family signaling	R-HSA-6783589	5.404088e-01	0.267
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	5.404088e-01	0.267
Plasma lipoprotein assembly	R-HSA-8963898	5.404088e-01	0.267
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.414614e-01	0.266
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.414614e-01	0.266
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.414614e-01	0.266
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	5.432809e-01	0.265
Signaling by PDGF	R-HSA-186797	5.478518e-01	0.261
ABC transporter disorders	R-HSA-5619084	5.508149e-01	0.259
Transport to the Golgi and subsequent modification	R-HSA-948021	5.624560e-01	0.250
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.646030e-01	0.248
MicroRNA (miRNA) biogenesis	R-HSA-203927	5.660379e-01	0.247
TGFBR3 expression	R-HSA-9839394	5.660379e-01	0.247
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.660379e-01	0.247
Acyl chain remodelling of PS	R-HSA-1482801	5.660379e-01	0.247
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.691159e-01	0.245
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	5.691159e-01	0.245
G beta:gamma signalling through PLC beta	R-HSA-418217	5.691159e-01	0.245
Polo-like kinase mediated events	R-HSA-156711	5.691159e-01	0.245
Presynaptic function of Kainate receptors	R-HSA-500657	5.691159e-01	0.245
Tie2 Signaling	R-HSA-210993	5.691159e-01	0.245
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.759013e-01	0.240
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.759013e-01	0.240
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.759013e-01	0.240
PI3K events in ERBB4 signaling	R-HSA-1250342	5.759013e-01	0.240
Sensing of DNA Double Strand Breaks	R-HSA-5693548	5.759013e-01	0.240
Antigen processing-Cross presentation	R-HSA-1236975	5.822219e-01	0.235
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.843265e-01	0.233
Resolution of D-Loop Structures	R-HSA-5693537	5.868204e-01	0.231
Effects of PIP2 hydrolysis	R-HSA-114508	5.868204e-01	0.231
Glucagon signaling in metabolic regulation	R-HSA-163359	5.868204e-01	0.231
Heme degradation	R-HSA-189483	5.868204e-01	0.231
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	5.908569e-01	0.229
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	5.945009e-01	0.226
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.945009e-01	0.226
G2 Phase	R-HSA-68911	5.945009e-01	0.226
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.945009e-01	0.226
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.945009e-01	0.226
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.945009e-01	0.226
Defective F9 activation	R-HSA-9673221	5.945009e-01	0.226
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	5.945009e-01	0.226
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.945009e-01	0.226
PTK6 Activates STAT3	R-HSA-8849474	5.945009e-01	0.226
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.945009e-01	0.226
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	5.945009e-01	0.226
Inositol transporters	R-HSA-429593	5.945009e-01	0.226
Nectin/Necl trans heterodimerization	R-HSA-420597	5.945009e-01	0.226
SMAC (DIABLO) binds to IAPs	R-HSA-111463	5.945009e-01	0.226
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.945009e-01	0.226
Co-inhibition by BTLA	R-HSA-9927353	5.945009e-01	0.226
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	5.945009e-01	0.226
Integration of energy metabolism	R-HSA-163685	5.957553e-01	0.225
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	5.977314e-01	0.223
Signaling by FGFR2 IIIa TM	R-HSA-8851708	5.977314e-01	0.223
The NLRP3 inflammasome	R-HSA-844456	5.977314e-01	0.223
Pre-NOTCH Processing in Golgi	R-HSA-1912420	5.977314e-01	0.223
Other interleukin signaling	R-HSA-449836	5.977314e-01	0.223
Signaling by NOTCH2	R-HSA-1980145	6.084047e-01	0.216
RUNX3 regulates p14-ARF	R-HSA-8951936	6.108433e-01	0.214
Repression of WNT target genes	R-HSA-4641265	6.108433e-01	0.214
GRB2 events in EGFR signaling	R-HSA-179812	6.108433e-01	0.214
OAS antiviral response	R-HSA-8983711	6.108433e-01	0.214
Cristae formation	R-HSA-8949613	6.148186e-01	0.211
Insulin processing	R-HSA-264876	6.148186e-01	0.211
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.250727e-01	0.204
Protein hydroxylation	R-HSA-9629569	6.250727e-01	0.204
Downstream signaling of activated FGFR2	R-HSA-5654696	6.293225e-01	0.201
Downstream signaling of activated FGFR1	R-HSA-5654687	6.293225e-01	0.201
Extension of Telomeres	R-HSA-180786	6.324279e-01	0.199
Telomere Extension By Telomerase	R-HSA-171319	6.378867e-01	0.195
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	6.378867e-01	0.195
Formation of the Early Elongation Complex	R-HSA-113418	6.378867e-01	0.195
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.424876e-01	0.192
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.424876e-01	0.192
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	6.435418e-01	0.191
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	6.435418e-01	0.191
Processing of SMDT1	R-HSA-8949664	6.435418e-01	0.191
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	6.435418e-01	0.191
Reversible hydration of carbon dioxide	R-HSA-1475029	6.435418e-01	0.191
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	6.435418e-01	0.191
Maturation of nucleoprotein	R-HSA-9683610	6.435418e-01	0.191
Replication of the SARS-CoV-1 genome	R-HSA-9682706	6.435418e-01	0.191
NGF-independant TRKA activation	R-HSA-187024	6.435698e-01	0.191
Plus-strand DNA synthesis	R-HSA-164525	6.435698e-01	0.191
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.435698e-01	0.191
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	6.435698e-01	0.191
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.435698e-01	0.191
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	6.435698e-01	0.191
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.435698e-01	0.191
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	6.435698e-01	0.191
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	6.435698e-01	0.191
Signaling by MST1	R-HSA-8852405	6.435698e-01	0.191
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.435698e-01	0.191
Cam-PDE 1 activation	R-HSA-111957	6.435698e-01	0.191
PKB-mediated events	R-HSA-109703	6.435698e-01	0.191
Phosphorylation of Emi1	R-HSA-176417	6.435698e-01	0.191
PDE3B signalling	R-HSA-165160	6.435698e-01	0.191
CDC6 association with the ORC:origin complex	R-HSA-68689	6.435698e-01	0.191
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.435698e-01	0.191
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.435698e-01	0.191
VEGF binds to VEGFR leading to receptor dimerization	R-HSA-195399	6.435698e-01	0.191
Signalling to p38 via RIT and RIN	R-HSA-187706	6.435698e-01	0.191
Sodium-coupled phosphate cotransporters	R-HSA-427652	6.435698e-01	0.191
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	6.435698e-01	0.191
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.435698e-01	0.191
VEGF ligand-receptor interactions	R-HSA-194313	6.435698e-01	0.191
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	6.435698e-01	0.191
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	6.435698e-01	0.191
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.435698e-01	0.191
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.438486e-01	0.191
Regulation of insulin secretion	R-HSA-422356	6.473496e-01	0.189
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	6.495473e-01	0.187
RNA Polymerase III Transcription	R-HSA-74158	6.495473e-01	0.187
Lysosome Vesicle Biogenesis	R-HSA-432720	6.495473e-01	0.187
RUNX2 regulates bone development	R-HSA-8941326	6.495473e-01	0.187
SHC-mediated cascade:FGFR3	R-HSA-5654704	6.511091e-01	0.186
Matriglycan biosynthesis on DAG1	R-HSA-9939291	6.511091e-01	0.186
TNFR1-induced proapoptotic signaling	R-HSA-5357786	6.511091e-01	0.186
Zygotic genome activation (ZGA)	R-HSA-9819196	6.511091e-01	0.186
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	6.511091e-01	0.186
Translation of Structural Proteins	R-HSA-9694635	6.555034e-01	0.183
mRNA Capping	R-HSA-72086	6.600351e-01	0.180
Regulation of gene expression in beta cells	R-HSA-210745	6.600351e-01	0.180
Signaling by Insulin receptor	R-HSA-74752	6.625417e-01	0.179
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.625417e-01	0.179
Ion channel transport	R-HSA-983712	6.643905e-01	0.178
Non-canonical inflammasome activation	R-HSA-9686114	6.740280e-01	0.171
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	6.740280e-01	0.171
SHC-mediated cascade:FGFR4	R-HSA-5654719	6.758265e-01	0.170
Attachment and Entry	R-HSA-9694614	6.758265e-01	0.170
Ribavirin ADME	R-HSA-9755088	6.758265e-01	0.170
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.761722e-01	0.170
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.761722e-01	0.170
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	6.778292e-01	0.169
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	6.778292e-01	0.169
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.784783e-01	0.168
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.788308e-01	0.168
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.811102e-01	0.167
Toll-like Receptor Cascades	R-HSA-168898	6.821854e-01	0.166
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	6.867034e-01	0.163
STAT5 Activation	R-HSA-9645135	6.867034e-01	0.163
Uncoating of the HIV Virion	R-HSA-162585	6.867034e-01	0.163
Metabolism of ingested MeSeO2H into MeSeH	R-HSA-5263617	6.867034e-01	0.163
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	6.867034e-01	0.163
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.867034e-01	0.163
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	6.867034e-01	0.163
MET Receptor Activation	R-HSA-6806942	6.867034e-01	0.163
NADPH regeneration	R-HSA-389542	6.867034e-01	0.163
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.867034e-01	0.163
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.867034e-01	0.163
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	6.867034e-01	0.163
VLDL assembly	R-HSA-8866423	6.867034e-01	0.163
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	6.867034e-01	0.163
Neurofascin interactions	R-HSA-447043	6.867034e-01	0.163
FCERI mediated Ca+2 mobilization	R-HSA-2871809	6.895887e-01	0.161
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.925270e-01	0.160
Signaling by TGFBR3	R-HSA-9839373	6.947968e-01	0.158
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	6.947968e-01	0.158
Regulation of pyruvate metabolism	R-HSA-9861718	6.947968e-01	0.158
Parasitic Infection Pathways	R-HSA-9824443	6.973595e-01	0.157
Leishmania infection	R-HSA-9658195	6.973595e-01	0.157
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.992248e-01	0.155
Telomere C-strand synthesis initiation	R-HSA-174430	7.023584e-01	0.153
Other semaphorin interactions	R-HSA-416700	7.023584e-01	0.153
Cardiac conduction	R-HSA-5576891	7.052402e-01	0.152
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.111583e-01	0.148
Regulation of PTEN mRNA translation	R-HSA-8943723	7.213156e-01	0.142
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.213156e-01	0.142
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.213156e-01	0.142
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.213156e-01	0.142
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	7.246194e-01	0.140
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	7.246194e-01	0.140
Disinhibition of SNARE formation	R-HSA-114516	7.246194e-01	0.140
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.246194e-01	0.140
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	7.246194e-01	0.140
Activation of TRKA receptors	R-HSA-187015	7.246194e-01	0.140
Activation of PUMA and translocation to mitochondria	R-HSA-139915	7.246194e-01	0.140
Activated NTRK3 signals through PI3K	R-HSA-9603381	7.246194e-01	0.140
LDL remodeling	R-HSA-8964041	7.246194e-01	0.140
VLDL clearance	R-HSA-8964046	7.246194e-01	0.140
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	7.246194e-01	0.140
Activation of SMO	R-HSA-5635838	7.286083e-01	0.138
Class I peroxisomal membrane protein import	R-HSA-9603798	7.286083e-01	0.138
Atorvastatin ADME	R-HSA-9754706	7.286083e-01	0.138
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	7.286083e-01	0.138
Differentiation of T cells	R-HSA-9945266	7.286083e-01	0.138
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	7.286083e-01	0.138
Virus Assembly and Release	R-HSA-168268	7.286083e-01	0.138
Transcriptional Regulation by VENTX	R-HSA-8853884	7.397504e-01	0.131
TRAF6 mediated NF-kB activation	R-HSA-933542	7.421204e-01	0.130
SHC-mediated cascade:FGFR1	R-HSA-5654688	7.421204e-01	0.130
Post-translational protein phosphorylation	R-HSA-8957275	7.452111e-01	0.128
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	7.528663e-01	0.123
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	7.528663e-01	0.123
Synthesis of PG	R-HSA-1483148	7.528663e-01	0.123
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	7.528663e-01	0.123
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.555718e-01	0.122
Signaling by FGFR2 in disease	R-HSA-5655253	7.565709e-01	0.121
Azathioprine ADME	R-HSA-9748787	7.565709e-01	0.121
Reverse Transcription of HIV RNA	R-HSA-162589	7.579487e-01	0.120
Minus-strand DNA synthesis	R-HSA-164516	7.579487e-01	0.120
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.579487e-01	0.120
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.579487e-01	0.120
phospho-PLA2 pathway	R-HSA-111995	7.579487e-01	0.120
Regulation of NPAS4 mRNA translation	R-HSA-9768778	7.579487e-01	0.120
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	7.579487e-01	0.120
Activation of RAS in B cells	R-HSA-1169092	7.579487e-01	0.120
TGFBR3 PTM regulation	R-HSA-9839383	7.579487e-01	0.120
Alpha-defensins	R-HSA-1462054	7.579487e-01	0.120
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	7.579487e-01	0.120
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.616690e-01	0.118
The phototransduction cascade	R-HSA-2514856	7.704876e-01	0.113
Stimuli-sensing channels	R-HSA-2672351	7.704923e-01	0.113
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.731797e-01	0.112
NOD1/2 Signaling Pathway	R-HSA-168638	7.731797e-01	0.112
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	7.752298e-01	0.111
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	7.752298e-01	0.111
Regulation of NPAS4 gene expression	R-HSA-9768759	7.752298e-01	0.111
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	7.752298e-01	0.111
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	7.752298e-01	0.111
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	7.752298e-01	0.111
Specification of primordial germ cells	R-HSA-9827857	7.752298e-01	0.111
Replication of the SARS-CoV-2 genome	R-HSA-9694686	7.752298e-01	0.111
MET activates PTK2 signaling	R-HSA-8874081	7.799975e-01	0.108
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	7.799975e-01	0.108
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.799975e-01	0.108
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.799975e-01	0.108
Lipophagy	R-HSA-9613354	7.872458e-01	0.104
WNT mediated activation of DVL	R-HSA-201688	7.872458e-01	0.104
Inactivation of CDC42 and RAC1	R-HSA-428543	7.872458e-01	0.104
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.872458e-01	0.104
Regulation of signaling by NODAL	R-HSA-1433617	7.872458e-01	0.104
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.872458e-01	0.104
Regulated proteolysis of p75NTR	R-HSA-193692	7.872458e-01	0.104
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.872458e-01	0.104
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	7.873628e-01	0.104
PERK regulates gene expression	R-HSA-381042	7.888103e-01	0.103
Pyruvate metabolism	R-HSA-70268	7.897408e-01	0.103
FOXO-mediated transcription of cell death genes	R-HSA-9614657	7.958021e-01	0.099
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	7.958021e-01	0.099
RNA Polymerase III Transcription Termination	R-HSA-73980	7.958021e-01	0.099
Mismatch Repair	R-HSA-5358508	7.958021e-01	0.099
NCAM signaling for neurite out-growth	R-HSA-375165	7.960283e-01	0.099
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.971474e-01	0.098
SHC-mediated cascade:FGFR2	R-HSA-5654699	7.971474e-01	0.098
Signaling by FGFR3 in disease	R-HSA-5655332	7.971474e-01	0.098
FCERI mediated MAPK activation	R-HSA-2871796	8.069789e-01	0.093
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.074331e-01	0.093
DNA replication initiation	R-HSA-68952	8.129984e-01	0.090
Formation of apoptosome	R-HSA-111458	8.129984e-01	0.090
Regulation of the apoptosome activity	R-HSA-9627069	8.129984e-01	0.090
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	8.129984e-01	0.090
CASP4 inflammasome assembly	R-HSA-9948001	8.129984e-01	0.090
Defective factor IX causes hemophilia B	R-HSA-9668250	8.129984e-01	0.090
Maturation of spike protein	R-HSA-9683686	8.129984e-01	0.090
Inflammasomes	R-HSA-622312	8.131638e-01	0.090
PI-3K cascade:FGFR3	R-HSA-5654710	8.146890e-01	0.089
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.146890e-01	0.089
TRAF6 mediated IRF7 activation	R-HSA-933541	8.174740e-01	0.088
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	8.183412e-01	0.087
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.280001e-01	0.082
PI-3K cascade:FGFR4	R-HSA-5654720	8.319971e-01	0.080
Formation of ATP by chemiosmotic coupling	R-HSA-163210	8.319971e-01	0.080
VxPx cargo-targeting to cilium	R-HSA-5620916	8.319971e-01	0.080
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.319971e-01	0.080
Formation of definitive endoderm	R-HSA-9823730	8.319971e-01	0.080
Protein localization	R-HSA-9609507	8.347309e-01	0.078
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	8.356351e-01	0.078
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	8.356351e-01	0.078
DAG1 core M3 glycosylations	R-HSA-8932505	8.356351e-01	0.078
LGI-ADAM interactions	R-HSA-5682910	8.356351e-01	0.078
vRNP Assembly	R-HSA-192905	8.356351e-01	0.078
vRNA Synthesis	R-HSA-192814	8.356351e-01	0.078
Chylomicron assembly	R-HSA-8963888	8.356351e-01	0.078
Utilization of Ketone Bodies	R-HSA-77108	8.356351e-01	0.078
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	8.356351e-01	0.078
Transport of RCbl within the body	R-HSA-9758890	8.356351e-01	0.078
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.356351e-01	0.078
Dissolution of Fibrin Clot	R-HSA-75205	8.356351e-01	0.078
Iron uptake and transport	R-HSA-917937	8.370701e-01	0.077
tRNA processing	R-HSA-72306	8.395602e-01	0.076
Dectin-2 family	R-HSA-5621480	8.416738e-01	0.075
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.419910e-01	0.075
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.419910e-01	0.075
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.419910e-01	0.075
Pentose phosphate pathway	R-HSA-71336	8.428564e-01	0.074
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.428564e-01	0.074
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.446900e-01	0.073
Metal ion SLC transporters	R-HSA-425410	8.465740e-01	0.072
G-protein activation	R-HSA-202040	8.478318e-01	0.072
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.478318e-01	0.072
Adipogenesis	R-HSA-9843745	8.489106e-01	0.071
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.549029e-01	0.068
Molecules associated with elastic fibres	R-HSA-2129379	8.549029e-01	0.068
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.555327e-01	0.068
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	8.555327e-01	0.068
Cytochrome c-mediated apoptotic response	R-HSA-111461	8.555327e-01	0.068
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.555327e-01	0.068
ERKs are inactivated	R-HSA-202670	8.555327e-01	0.068
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.555327e-01	0.068
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	8.555327e-01	0.068
Sodium/Calcium exchangers	R-HSA-425561	8.555327e-01	0.068
Proton-coupled monocarboxylate transport	R-HSA-433692	8.555327e-01	0.068
Triglyceride metabolism	R-HSA-8979227	8.610063e-01	0.065
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	8.622960e-01	0.064
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.622960e-01	0.064
Mitochondrial calcium ion transport	R-HSA-8949215	8.622960e-01	0.064
Serine metabolism	R-HSA-977347	8.622960e-01	0.064
Integrin cell surface interactions	R-HSA-216083	8.630301e-01	0.064
DAG1 glycosylations	R-HSA-8931838	8.668823e-01	0.062
Signaling by WNT in cancer	R-HSA-4791275	8.668823e-01	0.062
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	8.673336e-01	0.062
Metabolism of polyamines	R-HSA-351202	8.699164e-01	0.061
Maple Syrup Urine Disease	R-HSA-9865114	8.730227e-01	0.059
Defective EXT2 causes exostoses 2	R-HSA-3656237	8.730227e-01	0.059
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	8.730227e-01	0.059
RUNX3 regulates NOTCH signaling	R-HSA-8941856	8.730227e-01	0.059
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.730227e-01	0.059
Proline catabolism	R-HSA-70688	8.730227e-01	0.059
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.730227e-01	0.059
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.730227e-01	0.059
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.730227e-01	0.059
Intra-Golgi traffic	R-HSA-6811438	8.753110e-01	0.058
PI-3K cascade:FGFR1	R-HSA-5654689	8.754894e-01	0.058
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	8.754894e-01	0.058
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.754894e-01	0.058
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.754894e-01	0.058
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	8.754894e-01	0.058
Aquaporin-mediated transport	R-HSA-445717	8.783450e-01	0.056
FCERI mediated NF-kB activation	R-HSA-2871837	8.855216e-01	0.053
Disorders of transmembrane transporters	R-HSA-5619115	8.856479e-01	0.053
Free fatty acids regulate insulin secretion	R-HSA-400451	8.875078e-01	0.052
Formation of axial mesoderm	R-HSA-9796292	8.883961e-01	0.051
Microbial factors inhibit CASP4 activity	R-HSA-9956593	8.883961e-01	0.051
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.883961e-01	0.051
rRNA modification in the mitochondrion	R-HSA-6793080	8.883961e-01	0.051
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	8.913805e-01	0.050
Diseases of carbohydrate metabolism	R-HSA-5663084	8.959729e-01	0.048
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.984421e-01	0.047
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.984421e-01	0.047
Mitochondrial RNA degradation	R-HSA-9836573	8.984421e-01	0.047
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	9.019090e-01	0.045
cGMP effects	R-HSA-418457	9.019090e-01	0.045
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	9.019090e-01	0.045
Hydrolysis of LPC	R-HSA-1483115	9.019090e-01	0.045
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	9.019090e-01	0.045
Prolactin receptor signaling	R-HSA-1170546	9.019090e-01	0.045
Physiological factors	R-HSA-5578768	9.019090e-01	0.045
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.019090e-01	0.045
Malate-aspartate shuttle	R-HSA-9856872	9.019090e-01	0.045
Acyl chain remodeling of CL	R-HSA-1482798	9.019090e-01	0.045
Zinc transporters	R-HSA-435354	9.019090e-01	0.045
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.020212e-01	0.045
G alpha (z) signalling events	R-HSA-418597	9.075751e-01	0.042
PI-3K cascade:FGFR2	R-HSA-5654695	9.083786e-01	0.042
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.083786e-01	0.042
Laminin interactions	R-HSA-3000157	9.083786e-01	0.042
Hyaluronan degradation	R-HSA-2160916	9.083786e-01	0.042
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	9.137864e-01	0.039
Protein lipoylation	R-HSA-9857492	9.137864e-01	0.039
G beta:gamma signalling through BTK	R-HSA-8964315	9.137864e-01	0.039
Lysosphingolipid and LPA receptors	R-HSA-419408	9.137864e-01	0.039
DNA Damage Reversal	R-HSA-73942	9.137864e-01	0.039
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.145638e-01	0.039
FGFR2 mutant receptor activation	R-HSA-1839126	9.145638e-01	0.039
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.165693e-01	0.038
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.165693e-01	0.038
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	9.173986e-01	0.037
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.173986e-01	0.037
TRP channels	R-HSA-3295583	9.173986e-01	0.037
Defective GALNT3 causes HFTC	R-HSA-5083625	9.242263e-01	0.034
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	9.242263e-01	0.034
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.242263e-01	0.034
Killing mechanisms	R-HSA-9664420	9.242263e-01	0.034
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	9.242263e-01	0.034
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	9.242263e-01	0.034
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	9.242263e-01	0.034
Attachment and Entry	R-HSA-9678110	9.242263e-01	0.034
Post-translational protein modification	R-HSA-597592	9.268837e-01	0.033
Elastic fibre formation	R-HSA-1566948	9.288309e-01	0.032
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.288309e-01	0.032
Regulation of beta-cell development	R-HSA-186712	9.319067e-01	0.031
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.320465e-01	0.031
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.329889e-01	0.030
Insulin receptor recycling	R-HSA-77387	9.329889e-01	0.030
Glycine degradation	R-HSA-6783984	9.334025e-01	0.030
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.334025e-01	0.030
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.334025e-01	0.030
Fibronectin matrix formation	R-HSA-1566977	9.334025e-01	0.030
Heme assimilation	R-HSA-9927020	9.334025e-01	0.030
Transcriptional regulation of testis differentiation	R-HSA-9690406	9.334025e-01	0.030
Passive transport by Aquaporins	R-HSA-432047	9.334025e-01	0.030
Formation of xylulose-5-phosphate	R-HSA-5661270	9.334025e-01	0.030
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.334025e-01	0.030
Coenzyme A biosynthesis	R-HSA-196783	9.334025e-01	0.030
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.334025e-01	0.030
Metabolism of porphyrins	R-HSA-189445	9.400250e-01	0.027
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.408769e-01	0.026
Diseases of Immune System	R-HSA-5260271	9.408769e-01	0.026
SLC transporter disorders	R-HSA-5619102	9.414171e-01	0.026
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.414680e-01	0.026
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.414680e-01	0.026
Metabolism of proteins	R-HSA-392499	9.442668e-01	0.025
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.443127e-01	0.025
Neddylation	R-HSA-8951664	9.449586e-01	0.025
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.457631e-01	0.024
Mitochondrial protein import	R-HSA-1268020	9.462176e-01	0.024
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.462176e-01	0.024
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.485570e-01	0.023
Apoptotic factor-mediated response	R-HSA-111471	9.485570e-01	0.023
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	9.485570e-01	0.023
Scavenging by Class A Receptors	R-HSA-3000480	9.510090e-01	0.022
Amino acids regulate mTORC1	R-HSA-9639288	9.538479e-01	0.021
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	9.547879e-01	0.020
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.547879e-01	0.020
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.547879e-01	0.020
Diseases of hemostasis	R-HSA-9671793	9.547879e-01	0.020
Cytosolic tRNA aminoacylation	R-HSA-379716	9.554442e-01	0.020
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.561953e-01	0.019
Mitochondrial protein degradation	R-HSA-9837999	9.568992e-01	0.019
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.602643e-01	0.018
Signaling by NODAL	R-HSA-1181150	9.602643e-01	0.018
Acyl chain remodelling of PI	R-HSA-1482922	9.602643e-01	0.018
Creatine metabolism	R-HSA-71288	9.602643e-01	0.018
Pregnenolone biosynthesis	R-HSA-196108	9.602643e-01	0.018
Synthesis of Ketone Bodies	R-HSA-77111	9.602643e-01	0.018
Cardiogenesis	R-HSA-9733709	9.606619e-01	0.017
Recycling of bile acids and salts	R-HSA-159418	9.606619e-01	0.017
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.618930e-01	0.017
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.631467e-01	0.016
Amine ligand-binding receptors	R-HSA-375280	9.632094e-01	0.016
Acyl chain remodelling of PC	R-HSA-1482788	9.646896e-01	0.016
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.646896e-01	0.016
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.646896e-01	0.016
Miscellaneous transport and binding events	R-HSA-5223345	9.646896e-01	0.016
Interleukin-10 signaling	R-HSA-6783783	9.647345e-01	0.016
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.650506e-01	0.015
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.650777e-01	0.015
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.650777e-01	0.015
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.650777e-01	0.015
Abacavir metabolism	R-HSA-2161541	9.650777e-01	0.015
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.650777e-01	0.015
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.650777e-01	0.015
Acyl chain remodelling of PG	R-HSA-1482925	9.650777e-01	0.015
Formation of the cornified envelope	R-HSA-6809371	9.668999e-01	0.015
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.683190e-01	0.014
Signal amplification	R-HSA-392518	9.683190e-01	0.014
Hyaluronan metabolism	R-HSA-2142845	9.683190e-01	0.014
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.693083e-01	0.014
Molybdenum cofactor biosynthesis	R-HSA-947581	9.693083e-01	0.014
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.703057e-01	0.013
Acyl chain remodelling of PE	R-HSA-1482839	9.715876e-01	0.013
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.730266e-01	0.012
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.730266e-01	0.012
Neurotoxicity of clostridium toxins	R-HSA-168799	9.730266e-01	0.012
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.730266e-01	0.012
Biosynthesis of D-series resolvins	R-HSA-9018676	9.730266e-01	0.012
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.757685e-01	0.011
Leishmania parasite growth and survival	R-HSA-9664433	9.757685e-01	0.011
Termination of O-glycan biosynthesis	R-HSA-977068	9.762946e-01	0.010
Organic anion transport by SLCO transporters	R-HSA-879518	9.762946e-01	0.010
Ketone body metabolism	R-HSA-74182	9.762946e-01	0.010
Formation of the ureteric bud	R-HSA-9830674	9.762946e-01	0.010
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.762946e-01	0.010
Mitochondrial mRNA modification	R-HSA-9937008	9.762946e-01	0.010
Biosynthesis of maresins	R-HSA-9018682	9.762946e-01	0.010
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.771757e-01	0.010
Thromboxane signalling through TP receptor	R-HSA-428930	9.791668e-01	0.009
Complex III assembly	R-HSA-9865881	9.791668e-01	0.009
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.795548e-01	0.009
Gastrulation	R-HSA-9758941	9.814171e-01	0.008
Branched-chain amino acid catabolism	R-HSA-70895	9.814813e-01	0.008
G protein gated Potassium channels	R-HSA-1296059	9.816912e-01	0.008
Activation of G protein gated Potassium channels	R-HSA-1296041	9.816912e-01	0.008
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.816912e-01	0.008
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.816912e-01	0.008
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.824016e-01	0.008
CD22 mediated BCR regulation	R-HSA-5690714	9.828034e-01	0.008
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.828282e-01	0.008
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.836128e-01	0.007
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.839098e-01	0.007
Linoleic acid (LA) metabolism	R-HSA-2046105	9.839098e-01	0.007
Urea cycle	R-HSA-70635	9.839098e-01	0.007
Sphingolipid catabolism	R-HSA-9845614	9.839098e-01	0.007
Abacavir ADME	R-HSA-2161522	9.839098e-01	0.007
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.839098e-01	0.007
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.853366e-01	0.006
Maturation of spike protein	R-HSA-9694548	9.853366e-01	0.006
Signaling by BMP	R-HSA-201451	9.858597e-01	0.006
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.858597e-01	0.006
Maturation of hRSV A proteins	R-HSA-9828806	9.858597e-01	0.006
Nicotinate metabolism	R-HSA-196807	9.869948e-01	0.006
PPARA activates gene expression	R-HSA-1989781	9.873620e-01	0.006
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.875734e-01	0.005
Prednisone ADME	R-HSA-9757110	9.875734e-01	0.005
Thyroxine biosynthesis	R-HSA-209968	9.890795e-01	0.005
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.890795e-01	0.005
Glucagon-type ligand receptors	R-HSA-420092	9.890795e-01	0.005
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.890795e-01	0.005
PI Metabolism	R-HSA-1483255	9.901707e-01	0.004
COPII-mediated vesicle transport	R-HSA-204005	9.902018e-01	0.004
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.902018e-01	0.004
Neurotransmitter clearance	R-HSA-112311	9.904031e-01	0.004
Cell surface interactions at the vascular wall	R-HSA-202733	9.905683e-01	0.004
Methylation	R-HSA-156581	9.906292e-01	0.004
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.906292e-01	0.004
ECM proteoglycans	R-HSA-3000178	9.910914e-01	0.004
Metabolism of cofactors	R-HSA-8978934	9.910914e-01	0.004
FCGR activation	R-HSA-2029481	9.912122e-01	0.004
Cargo concentration in the ER	R-HSA-5694530	9.915664e-01	0.004
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.917681e-01	0.004
RAB geranylgeranylation	R-HSA-8873719	9.925741e-01	0.003
tRNA Aminoacylation	R-HSA-379724	9.925741e-01	0.003
Inwardly rectifying K+ channels	R-HSA-1296065	9.925887e-01	0.003
HS-GAG degradation	R-HSA-2024096	9.925887e-01	0.003
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.933227e-01	0.003
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.934872e-01	0.003
Extracellular matrix organization	R-HSA-1474244	9.937970e-01	0.003
Citric acid cycle (TCA cycle)	R-HSA-71403	9.939352e-01	0.003
Complex I biogenesis	R-HSA-6799198	9.945599e-01	0.002
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.946800e-01	0.002
Chemokine receptors bind chemokines	R-HSA-380108	9.946800e-01	0.002
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.949706e-01	0.002
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.949706e-01	0.002
Transferrin endocytosis and recycling	R-HSA-917977	9.955804e-01	0.002
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.955804e-01	0.002
Neurotransmitter release cycle	R-HSA-112310	9.956524e-01	0.002
G alpha (s) signalling events	R-HSA-418555	9.960218e-01	0.002
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.960261e-01	0.002
HS-GAG biosynthesis	R-HSA-2022928	9.961163e-01	0.002
G alpha (q) signalling events	R-HSA-416476	9.965284e-01	0.002
Voltage gated Potassium channels	R-HSA-1296072	9.965873e-01	0.001
Collagen chain trimerization	R-HSA-8948216	9.965873e-01	0.001
Metabolism of folate and pterines	R-HSA-196757	9.965873e-01	0.001
Nucleotide biosynthesis	R-HSA-8956320	9.966328e-01	0.001
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.971407e-01	0.001
Asparagine N-linked glycosylation	R-HSA-446203	9.972937e-01	0.001
Paracetamol ADME	R-HSA-9753281	9.973248e-01	0.001
Role of phospholipids in phagocytosis	R-HSA-2029485	9.974332e-01	0.001
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.976594e-01	0.001
rRNA processing in the mitochondrion	R-HSA-8868766	9.976844e-01	0.001
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.976844e-01	0.001
Purine catabolism	R-HSA-74259	9.978963e-01	0.001
Aflatoxin activation and detoxification	R-HSA-5423646	9.979653e-01	0.001
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.982121e-01	0.001
Heme biosynthesis	R-HSA-189451	9.982121e-01	0.001
Amino acid transport across the plasma membrane	R-HSA-352230	9.983154e-01	0.001
Activation of GABAB receptors	R-HSA-991365	9.984290e-01	0.001
GABA B receptor activation	R-HSA-977444	9.984290e-01	0.001
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.984749e-01	0.001
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.984814e-01	0.001
Defensins	R-HSA-1461973	9.986196e-01	0.001
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.986196e-01	0.001
Pyrimidine catabolism	R-HSA-73621	9.986196e-01	0.001
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.987870e-01	0.001
Metabolism of amino acids and derivatives	R-HSA-71291	9.988964e-01	0.000
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.989342e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.990101e-01	0.000
Collagen formation	R-HSA-1474290	9.992593e-01	0.000
Plasma lipoprotein remodeling	R-HSA-8963899	9.992770e-01	0.000
SLC-mediated transport of amino acids	R-HSA-9958863	9.993378e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.994112e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.994263e-01	0.000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.994418e-01	0.000
Complex IV assembly	R-HSA-9864848	9.995096e-01	0.000
Aspirin ADME	R-HSA-9749641	9.996735e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.997432e-01	0.000
Synthesis of PA	R-HSA-1483166	9.997744e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.998195e-01	0.000
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.998259e-01	0.000
GABA receptor activation	R-HSA-977443	9.998470e-01	0.000
Collagen degradation	R-HSA-1442490	9.998656e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.998737e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.998881e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.998915e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.998994e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999044e-01	0.000
Xenobiotics	R-HSA-211981	9.999089e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999130e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999133e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999319e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999382e-01	0.000
Kidney development	R-HSA-9830369	9.999382e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.999382e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.999457e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999507e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999575e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.999581e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999619e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.999632e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.999632e-01	0.000
Keratinization	R-HSA-6805567	9.999634e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.999663e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999746e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.999750e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999778e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999809e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999814e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.999851e-01	0.000
Potassium Channels	R-HSA-1296071	9.999855e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999857e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999869e-01	0.000
Drug ADME	R-HSA-9748784	9.999874e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999899e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999899e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999954e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999959e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999966e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999976e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999977e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999984e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999987e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999988e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999989e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999989e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999994e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999996e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.999999e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999999e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999999e-01	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000