GSK3B

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0	S939	Sugiyama	POTEF A26C1B	VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A5A3E0	Y1062	Sugiyama	POTEF A26C1B	GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCL_______
E9PAV3	T2022	SIGNOR\|EPSD\|PSP	NACA	AAEKFKVQGEAVsNIQENtQtPtVQEEsEEEEVDEtGVEVK
O00213	T579	EPSD\|PSP	APBB1 FE65 RIR	VDVINGALESVLSSSSREQWtPSHVSVAPATLTILHQQTEA
O00327	S17	SIGNOR\|EPSD\|PSP	BMAL1 ARNTL BHLHE5 MOP3 PASD3	____MADQRMDISSTISDFMsPGPtDLLSSSLGTSGVDCNR
O00327	T21	SIGNOR\|EPSD\|PSP	BMAL1 ARNTL BHLHE5 MOP3 PASD3	MADQRMDISSTISDFMsPGPtDLLSSSLGTSGVDCNRKRKG
O00429	S40	SIGNOR\|EPSD\|PSP	DNM1L DLP1 DRP1	ADIIQLPQIVVVGTQSSGKSsVLEsLVGRDLLPRGTGIVTR
O00429	S44	SIGNOR\|EPSD\|PSP	DNM1L DLP1 DRP1	QLPQIVVVGTQSSGKSsVLEsLVGRDLLPRGTGIVTRRPLI
O00429	S616	PSP	DNM1L DLP1 DRP1	SKAEELLAEEKsKPIPIMPAsPQKGHAVNLLDVPVPVARKL
O00429	S693	SIGNOR\|EPSD\|PSP	DNM1L DLP1 DRP1	FLVNHVKDTLQSELVGQLyKsSLLDDLLtESEDMAQRRKEA
O14965	S283	SIGNOR	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	LLGsAGELKIADFGWsVHAPssRRttLCGTLDYLPPEMIEG
O15033	T783	SIGNOR\|EPSD	AREL1 KIAA0317	PGGFAALCPSFQIIAAPTHStLPTAHTCFNQLCLPTYDSYE
O15067	S1062	Sugiyama	PFAS KIAA0361	SYCLPPTFPKAsVPREPGGPsPRVAILREEGSNGDREMADA
O15085	S1457	Sugiyama	ARHGEF11 KIAA0380	NRLKDMELAHRELLKsLGGEssGGttPVGSFHTEAARWTDG
O15085	S1458	Sugiyama	ARHGEF11 KIAA0380	RLKDMELAHRELLKsLGGEssGGttPVGSFHTEAARWTDGs
O15169	S486	SIGNOR	AXIN1 AXIN	NPEsILDEHVQRVLRtPGRQsPGPGHRsPDSGHVAKMPVAL
O15169	S614	iPTMNet\|EPSD	AXIN1 AXIN	HSGKVGVACKRNAKKAESGKsASTEVPGASEDAEKNQKIMQ
O15169	T481	SIGNOR	AXIN1 AXIN	DAHEENPEsILDEHVQRVLRtPGRQsPGPGHRsPDSGHVAK
O15273	S157	SIGNOR\|PSP	TCAP	TKQLPPVVPVSKPGALRRSLsRSMsQEAQRG__________
O15273	S161	PSP	TCAP	PPVVPVSKPGALRRSLsRSMsQEAQRG______________
O15294	S3	SIGNOR\|EPSD\|PSP	OGT	__________________MAssVGNVADSTEPTKRMLsFQG
O15294	S4	SIGNOR\|EPSD\|PSP	OGT	_________________MAssVGNVADSTEPTKRMLsFQGL
O15516	S427	SIGNOR\|EPSD\|PSP	CLOCK BHLHE8 KIAA0334	GsDNRINTVSLKEALERFDHsPTPsASsRSsRKssHtAVsD
O43432	S1409	Sugiyama	EIF4G3	EGEDVHNFLLEQKLDFIEsDsPCssEALSKKELSAEELYKR
O43602	S332	SIGNOR	DCX DBCN LISX	NDQDANGTSSSQLStPKsKQsPIstPtsPGSLRKHKDLYLP
O43623	S100	EPSD\|PSP	SNAI2 SLUG SLUGH	SSSLGRVsPPPPsDTSsKDHsGSEsPIsDEEERLQSKLSDP
O43623	S104	EPSD\|PSP	SNAI2 SLUG SLUGH	GRVsPPPPsDTSsKDHsGSEsPIsDEEERLQSKLSDPHAIE
O43623	S92	EPSD\|PSP	SNAI2 SLUG SLUGH	GLSPLSGYSSSLGRVsPPPPsDTSsKDHsGSEsPIsDEEER
O43623	S96	EPSD\|PSP	SNAI2 SLUG SLUGH	LSGYSSSLGRVsPPPPsDTSsKDHsGSEsPIsDEEERLQSK
O43765	S77	Sugiyama	SGTA SGT SGT1	TLPEIFEAAATGKEMPQDLRsPARtPPsEEDsAEAERLKTE
O43765	T81	Sugiyama	SGTA SGT SGT1	IFEAAATGKEMPQDLRsPARtPPsEEDsAEAERLKTEGNEQ
O43852	T196	Sugiyama	CALU	FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O43852	T65	Sugiyama	CALU	FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60341	S683	EPSD\|PSP	KDM1A AOF2 KDM1 KIAA0601 LSD1	VLCFDRVFWDPSVNLFGHVGsTTAsRGELFLFWNLYKAPIL
O60346	S1359	SIGNOR\|EPSD\|PSP	PHLPP1 KIAA0606 PHLPP PLEKHE1 SCOP	TRILGYTFLHPSVVPRPHVQsVLLtPQDEFFILGSKGLWDs
O60346	S1379	EPSD\|PSP	PHLPP1 KIAA0606 PHLPP PLEKHE1 SCOP	sVLLtPQDEFFILGSKGLWDsLsVEEAVEAVRNVPDALAAA
O60346	S1381	EPSD\|PSP	PHLPP1 KIAA0606 PHLPP PLEKHE1 SCOP	LLtPQDEFFILGSKGLWDsLsVEEAVEAVRNVPDALAAAKK
O60346	T1363	SIGNOR\|EPSD\|PSP	PHLPP1 KIAA0606 PHLPP PLEKHE1 SCOP	GYTFLHPSVVPRPHVQsVLLtPQDEFFILGSKGLWDsLsVE
O60361	Y136	Sugiyama	NME2P1	SLRFKPEELVDYKSCAHDWVyE___________________
O60701	T185	Sugiyama	UGDH	EGTAIKDLKNPDRVLIGGDEtPEGQRAVQALCAVYEHWVPR
O60716	S252	SIGNOR\|iPTMNet\|EPSD\|Sugiyama	CTNND1 KIAA0384	sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60716	T310	SIGNOR\|iPTMNet\|EPSD	CTNND1 KIAA0384	GyDDLDyGMMsDyGtARRtGtPsDPRRRLRsyEDMIGEEVP
O75030	S405	GPS6\|SIGNOR	MITF BHLHE32	NRHLLLRIQELEMQARAHGLsLIPsTGLCsPDLVNRIIKQE
O75116	S425	Sugiyama	ROCK2 KIAA0619	GNQLPFIGFTYYRENLLLsDsPSCRETDSIQSRKNEESQEI
O75122	S499	EPSD\|PSP	CLASP2 KIAA0627	GVQRVLVNsAsAQKRSKIPRsQGCsREAsPSRLSVARSSRI
O75122	S503	EPSD\|PSP	CLASP2 KIAA0627	VLVNsAsAQKRSKIPRsQGCsREAsPSRLSVARSSRIPRPs
O75122	S507	EPSD\|PSP	CLASP2 KIAA0627	sAsAQKRSKIPRsQGCsREAsPSRLSVARSSRIPRPsVsQG
O75122	S533	SIGNOR\|EPSD\|PSP	CLASP2 KIAA0627	VARSSRIPRPsVsQGCsREAsRESsRDTsPVRSFQPLASRH
O75122	S537	SIGNOR\|EPSD\|PSP	CLASP2 KIAA0627	SRIPRPsVsQGCsREAsRESsRDTsPVRSFQPLASRHHSRS
O75385	S405	GPS6	ULK1 KIAA0722	SGSSLVASAGLESHGRtPsPsPPCsssPsPsGRAGPFSsSR
O75385	S415	GPS6	ULK1 KIAA0722	LESHGRtPsPsPPCsssPsPsGRAGPFSsSRCGASVPIPVP
O75533	T223	Sugiyama	SF3B1 SAP155	tADQtPGAtPKKLssWDQAEtPGHtPsLRWDEtPGRAKGsE
O75533	T227	Sugiyama	SF3B1 SAP155	tPGAtPKKLssWDQAEtPGHtPsLRWDEtPGRAKGsEtPGA
O75581	S1490	SIGNOR\|iPTMNet\|EPSD\|PSP	LRP6	SSSSssTKGtYFPAILNPPPsPAtERsHYTMEFGYSsNsPs
O75581	S1607	iPTMNet\|EPSD	LRP6	CPPsPYTERSYSHHLYPPPPsPCTDss______________
O75581	T1572	iPTMNet\|EPSD	LRP6	TAKGYTSDLNyDSEPVPPPPtPRSQYLSAEENyESCPPsPY
O75925	S13	SIGNOR\|PSP	PIAS1 DDXBP1	________MADSAELKQMVMsLRVsELQVLLGYAGRNKHGR
O75925	S17	SIGNOR\|PSP	PIAS1 DDXBP1	____MADSAELKQMVMsLRVsELQVLLGYAGRNKHGRKHEL
O75952	S155	SIGNOR\|iPTMNet\|EPSD\|PSP	CABYR CBP86 FSP2	EAVGGLsSKPAtPKTTtPPssPPPTAVSPEFAYVPADPAQL
O75952	T151	SIGNOR\|iPTMNet\|EPSD\|PSP	CABYR CBP86 FSP2	TEQTEAVGGLsSKPAtPKTTtPPssPPPTAVSPEFAYVPAD
O94979	S188	Sugiyama	SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334	PEDISCIAWNRQVQHILAsAsPsGRATVWDLRKNEPIIKVS
O94979	S190	Sugiyama	SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334	DISCIAWNRQVQHILAsAsPsGRATVWDLRKNEPIIKVSDH
O94979	S799	Sugiyama	SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334	IMQLRDRLCRAQGEPVAGHEsPKIPyEKQQLPKGRPGPVAG
O95271	S978	EPSD\|PSP	TNKS PARP5A PARPL TIN1 TINF1 TNKS1	PEALPTCFKPQATVVSASLIsPAStPSCLsAASsIDNLTGP
O95271	S987	EPSD\|PSP	TNKS PARP5A PARPL TIN1 TINF1 TNKS1	PQATVVSASLIsPAStPSCLsAASsIDNLTGPLAELAVGGA
O95271	S991	EPSD\|PSP	TNKS PARP5A PARPL TIN1 TINF1 TNKS1	VVSASLIsPAStPSCLsAASsIDNLTGPLAELAVGGASNAG
O95271	T982	EPSD\|PSP	TNKS PARP5A PARPL TIN1 TINF1 TNKS1	PTCFKPQATVVSASLIsPAStPSCLsAASsIDNLTGPLAEL
O95757	T35	Sugiyama	HSPA4L APG1 HSPH3 OSP94	IAVARsGGIETIANEySDRCtPACIsLGSRTRAIGNAAKSQ
O95863	S100	SIGNOR\|EPSD\|PSP	SNAI1 SNAH	QEsPRVAELTSLsDEDsGKGsQPPsPPsPAPsSFSsTSVsS
O95863	S104	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	SNAI1 SNAH	RVAELTSLsDEDsGKGsQPPsPPsPAPsSFSsTSVsSLEAE
O95863	S107	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	SNAI1 SNAH	ELTSLsDEDsGKGsQPPsPPsPAPsSFSsTSVsSLEAEAYA
O95863	S111	SIGNOR\|EPSD\|PSP	SNAI1 SNAH	LsDEDsGKGsQPPsPPsPAPsSFSsTSVsSLEAEAYAAFPG
O95863	S115	SIGNOR\|EPSD\|PSP	SNAI1 SNAH	DsGKGsQPPsPPsPAPsSFSsTSVsSLEAEAYAAFPGLGQV
O95863	S119	SIGNOR\|EPSD\|PSP	SNAI1 SNAH	GsQPPsPPsPAPsSFSsTSVsSLEAEAYAAFPGLGQVPKQL
O95863	S96	SIGNOR\|EPSD\|PSP	SNAI1 SNAH	SLRLQEsPRVAELTSLsDEDsGKGsQPPsPPsPAPsSFSsT
O95997	S183	SIGNOR\|PSP	PTTG1 EAP1 PTTG TUTR1	PPsPVKMPsPPWESNLLQsPssILSTLDVELPPVCCDIDI_
O95997	S184	SIGNOR\|PSP	PTTG1 EAP1 PTTG TUTR1	PsPVKMPsPPWESNLLQsPssILSTLDVELPPVCCDIDI__
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00966	Y163	Sugiyama	ASS1 ASS	APWRMPEFYNRFKGRNDLMEyAKQHGIPIPVtPKNPWSMDE
P01106	S77	PSP	MYC BHLHE39	PPAPSEDIWKKFELLPtPPLsPsRRsGLCsPSyVAVTPFsL
P01106	T73	iPTMNet\|PSP	MYC BHLHE39	SELQPPAPSEDIWKKFELLPtPPLsPsRRsGLCsPSyVAVT
P01112	S183	PSP	HRAS HRAS1	IRQHKLRKLNPPDESGPGCMsCKCVLS______________
P01112	T144	EPSD\|PSP	HRAS HRAS1	TVESRQAQDLARSyGIPYIEtSAKtRQGVEDAFytLVREIR
P01112	T148	EPSD\|PSP	HRAS HRAS1	RQAQDLARSyGIPYIEtSAKtRQGVEDAFytLVREIRQHKL
P03372	S102	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	ESR1 ESR NR3A1	PGSEAAAFGSNGLGGFPPLNsVsPsPLMLLHPPPQLsPFLQ
P03372	S104	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	ESR1 ESR NR3A1	SEAAAFGSNGLGGFPPLNsVsPsPLMLLHPPPQLsPFLQPH
P03372	S106	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	ESR1 ESR NR3A1	AAAFGSNGLGGFPPLNsVsPsPLMLLHPPPQLsPFLQPHGQ
P03372	S118	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	ESR1 ESR NR3A1	PPLNsVsPsPLMLLHPPPQLsPFLQPHGQQVPYYLENEPSG
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04150	S404	SIGNOR\|EPSD\|PSP	NR3C1 GRL	PGRTVFSNGYssPSMRPDVssPPSSSStATTGPPPKLCLVC
P04198	T58	PSP	MYCN BHLHE37 NMYC	GGPDSTPPGEDIWKKFELLPtPPLsPsRGFAEHSSEPPSWV
P04637	S33	SIGNOR\|ELM\|iPTMNet\|EPSD	TP53 P53	PLsQEtFsDLWKLLPENNVLsPLPsQAMDDLMLsPDDIEQW
P04637	S376	EPSD\|PSP	TP53 P53	GKEPGGSRAHssHLKsKKGQstsRHKKLMFKtEGPDsD___
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05067	T743	GPS6\|SIGNOR\|ELM\|EPSD	APP A4 AD1	LKKKQYtsIHHGVVEVDAAVtPEERHLSKMQQNGyENPtyK
P05187	S114	Sugiyama	ALPP PLAP	DRFPYVALSKTYNVDKHVPDsGAtATAYLCGVKGNFQTIGL
P05412	S243	GPS6\|SIGNOR\|EPSD\|PSP	JUN	QALKEEPQtVPEMPGEtPPLsPIDMEsQERIKAERKRMRNR
P05412	S249	GPS6\|SIGNOR\|EPSD	JUN	PQtVPEMPGEtPPLsPIDMEsQERIKAERKRMRNRIAASKC
P05412	T239	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	JUN	HPRLQALKEEPQtVPEMPGEtPPLsPIDMEsQERIKAERKR
P05787	S274	Sugiyama	KRT8 CYK8	LDMDsIIAEVKAQyEDIANRsRAEAEsMyQIKyEELQsLAG
P06401	S554	SIGNOR	PGR NR3C3	LPQVYPPYLNYLRPDsEAsQsPQYsFEsLPQKICLICGDEA
P06733	S37	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06733	S40	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06744	S455	Sugiyama	GPI	ALMRGKSTEEARKELQAAGKsPEDLERLLPHKVFEGNRPTN
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	S70	Sugiyama	LDHB	ALVDVLEDKLKGEMMDLQHGsLFLQtPKIVADKDysVtANS
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07195	T75	Sugiyama	LDHB	LEDKLKGEMMDLQHGsLFLQtPKIVADKDysVtANSKIVVV
P07437	S168	Sugiyama	TUBB TUBB5 OK/SW-cl.56	GTLLISKIREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLS
P07437	S172	Sugiyama	TUBB TUBB5 OK/SW-cl.56	ISKIREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLSVHQL
P07437	S75	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S263	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	S726	PSP	HSP90AA1 HSP90A HSPC1 HSPCA	DDtsAAVtEEMPPLEGDDDtsRMEEVD______________
P07900	T725	PSP	HSP90AA1 HSP90A HSPC1 HSPCA	ADDtsAAVtEEMPPLEGDDDtsRMEEVD_____________
P07900	Y309	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07942	T1141	Sugiyama	LAMB1	FWGDPDVECRACDCDPRGIEtPQCDQSTGQCVCVEGVEGPR
P08047	S728	PSP	SP1 TSFP1	HQNKKGGPGVALsVGtLPLDsGAGsEGSGtAtPSALITTNM
P08047	S732	PSP	SP1 TSFP1	KGGPGVALsVGtLPLDsGAGsEGSGtAtPSALITTNMVAME
P08195	S598	Sugiyama	SLC3A2 MDU1	LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195	S607	Sugiyama	SLC3A2 MDU1	ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238	S718	PSP	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	EEPNAAVPDEIPPLEGDEDAsRMEEVD______________
P08238	T467	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238	Y301	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08865	T97	Sugiyama	RPSA LAMBR LAMR1	IssRNtGQRAVLKFAAAtGAtPIAGRFtPGTFTNQIQAAFR
P09104	S37	Sugiyama	ENO2	NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY
P09104	S40	Sugiyama	ENO2	VEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGK
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG38	Y1062	Sugiyama	POTEI	GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	Y1025	Sugiyama	POTEJ	GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P0DMV8	T636	PSP	HSPA1A HSP72 HSPA1 HSX70	GPGPGGFGAQGPKGGsGsGPtIEEVD_______________
P10070	S820	SIGNOR	GLI2 THP	SQLQERRDsstsTVSSAYTVsRRssGISPYFSsRRssEAsP
P10070	S832	SIGNOR	GLI2 THP	TVSSAYTVsRRssGISPYFSsRRssEAsPLGAGRPHNAssA
P10070	S863	SIGNOR	GLI2 THP	AGRPHNAssADSYDPISTDAsRRsSEASQCSGGSGLLNLTP
P10636	S214	GPS6	MAPT MAPTL MTBT1 TAU	GDLHQEGPPLKGAGGKERPGsKEEVDEDRDVDESsPQDsPP
P10636	S235	GPS6	MAPT MAPTL MTBT1 TAU	KEEVDEDRDVDESsPQDsPPsKAsPAQDGRPPQTAAREATS
P10636	S396	GPS6\|SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	ARMVSKSKDGtGSDDKKAKTsTRSsAKtLKNRPCLsPKHPT
P10636	S400	GPS6\|SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	SKSKDGtGSDDKKAKTsTRSsAKtLKNRPCLsPKHPTPGSs
P10636	S46	EPSD\|PSP	MAPT MAPTL MTBT1 TAU	QGGytMHQDQEGDtDAGLKEsPLQtPTEDGsEEPGsETSDA
P10636	S501	EPSD	MAPT MAPTL MTBT1 TAU	GQANATRIPAKtPPAPKtPPsSGEPPKsGDRsGyssPGsPG
P10636	S512	SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	tPPAPKtPPsSGEPPKsGDRsGyssPGsPGtPGsRsRtPsL
P10636	S515	SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	APKtPPsSGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtP
P10636	S516	SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	PKtPPsSGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtPP
P10636	S519	SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	PPsSGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtPPTRE
P10636	S525	EPSD	MAPT MAPTL MTBT1 TAU	PPKsGDRsGyssPGsPGtPGsRsRtPsLPtPPTREPKKVAV
P10636	S531	SIGNOR	MAPT MAPTL MTBT1 TAU	RsGyssPGsPGtPGsRsRtPsLPtPPTREPKKVAVVRtPPK
P10636	S552	GPS6\|ELM\|EPSD	MAPT MAPTL MTBT1 TAU	LPtPPTREPKKVAVVRtPPKsPssAKSRLQTAPVPMPDLKN
P10636	S575	GPS6\|ELM\|EPSD	MAPT MAPTL MTBT1 TAU	sAKSRLQTAPVPMPDLKNVKsKIGstENLKHQPGGGKVQII
P10636	S579	GPS6\|SIGNOR\|ELM\|EPSD	MAPT MAPTL MTBT1 TAU	RLQTAPVPMPDLKNVKsKIGstENLKHQPGGGKVQIINKKL
P10636	S713	GPS6\|SIGNOR\|ELM\|EPSD	MAPT MAPTL MTBT1 TAU	LTFRENAKAKTDHGAEIVyKsPVVsGDtsPRHLsNVsstGs
P10636	S717	SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	ENAKAKTDHGAEIVyKsPVVsGDtsPRHLsNVsstGsIDMV
P10636	S721	GPS6\|SIGNOR\|ELM\|EPSD	MAPT MAPTL MTBT1 TAU	AKTDHGAEIVyKsPVVsGDtsPRHLsNVsstGsIDMVDsPQ
P10636	S730	EPSD	MAPT MAPTL MTBT1 TAU	VyKsPVVsGDtsPRHLsNVsstGsIDMVDsPQLAtLADEVS
P10636	T123	iPTMNet\|EPSD	MAPT MAPTL MTBT1 TAU	AEEAGIGDtPSLEDEAAGHVtQEPESGKVVQEGFLREPGPP
P10636	T173	iPTMNet	MAPT MAPTL MTBT1 TAU	MPGAPLLPEGPREATRQPsGtGPEDTEGGRHAPELLKHQLL
P10636	T498	SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	GQKGQANATRIPAKtPPAPKtPPsSGEPPKsGDRsGyssPG
P10636	T50	EPSD\|PSP	MAPT MAPTL MTBT1 TAU	tMHQDQEGDtDAGLKEsPLQtPTEDGsEEPGsETSDAKstP
P10636	T522	SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	SGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtPPTREPKK
P10636	T529	SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	GDRsGyssPGsPGtPGsRsRtPsLPtPPTREPKKVAVVRtP
P10636	T534	SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	yssPGsPGtPGsRsRtPsLPtPPTREPKKVAVVRtPPKsPs
P10636	T548	GPS6\|SIGNOR\|ELM\|EPSD	MAPT MAPTL MTBT1 TAU	RtPsLPtPPTREPKKVAVVRtPPKsPssAKSRLQTAPVPMP
P10696	S111	Sugiyama	ALPG ALPPL ALPPL2	DRFPYVALSKTYSVDKHVPDsGAtATAYLCGVKGNFQTIGL
P10809	S225	Sugiyama	HSPD1 HSP60	KtLNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVL
P10809	S70	Sugiyama	HSPD1 HSP60	AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P10809	T455	Sugiyama	HSPD1 HSP60	GIVLGGGCALLRCIPALDsLtPANEDQKIGIEIIKRTLKIP
P10914	S184	PSP	IRF1	YTVPGYMQDLEVEQALtPALsPCAVSSTLPDWHIPVEVVPD
P10914	T180	PSP	IRF1	DHSSYTVPGYMQDLEVEQALtPALsPCAVSSTLPDWHIPVE
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T37	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142	T38	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11142	Y41	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11308	T180	SIGNOR\|PSP	ERG	FQNIDGKELCKMTKDDFQRLtPSyNADILLSHLHYLRETPL
P11388	S1361	SIGNOR\|EPSD\|PSP	TOP2A TOP2	EKtDDEDFVPsDAsPPKtKTsPKLsNKELKPQKsVVsDLEA
P11586	S129	Sugiyama	MTHFD1 MTHFC MTHFD	INTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCtP
P11831	S224	PSP	SRF	PMITSETGKALIQtCLNsPDsPPRsDPttDQRMSATGFEET
P12036	S503	SIGNOR\|EPSD\|PSP	NEFH KIAA0845 NFH	GKEEEGGEEEEAEGGEEEtKsPPAEEAAsPEKEAKsPVKEE
P12524	S38	EPSD\|PSP	MYCL BHLHE38 LMYC MYCL1	DFYRSTAPSEDIWKKFELVPsPPTsPPWGLGPGAGDPAPGI
P12524	S42	EPSD\|PSP	MYCL BHLHE38 LMYC MYCL1	STAPSEDIWKKFELVPsPPTsPPWGLGPGAGDPAPGIGPPE
P12830	S847	SIGNOR\|iPTMNet\|EPSD	CDH1 CDHE UVO	YDSLLVFDYEGsGsEAAsLSsLNssEsDKDQDYDYLNEWGN
P12931	S43	SIGNOR\|PSP	SRC SRC1	NVHGAGGGAFPAsQtPsKPAsADGHRGPsAAFAPAAAEPKL
P12931	S493	GPS6\|SIGNOR\|PSP	SRC SRC1	EVLDQVERGYRMPCPPECPEsLHDLMCQCWRKEPEERPTFE
P12931	S51	GPS6\|PSP	SRC SRC1	AFPAsQtPsKPAsADGHRGPsAAFAPAAAEPKLFGGFNssD
P12931	Y419	PSP	SRC SRC1	ENLVCKVADFGLARLIEDNEytARQGAKFPIKWTAPEAALy
P13051	S64	SIGNOR\|EPSD\|PSP	UNG DGU UNG1 UNG15	AAIPAKKAPAGQEEPGtPPssPLsAEQLDRIQRNKAAALLR
P13051	T60	SIGNOR\|EPSD\|PSP	UNG DGU UNG1 UNG15	SGDAAAIPAKKAPAGQEEPGtPPssPLsAEQLDRIQRNKAA
P13489	T176	Sugiyama	RNH1 PRI RNH	AASCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKD
P13688	S508	PSP	CEACAM1 BGP BGP1	MNEVtysTLNFEAQQPTQPTsASPsLTATEIIySEVKKQ__
P13807	S641	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	GYS1 GYS	FTYEPNEADAAQGyRyPRPAsVPPsPsLsRHssPHQsEDEE
P13807	S645	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	GYS1 GYS	PNEADAAQGyRyPRPAsVPPsPsLsRHssPHQsEDEEDPRN
P13807	S649	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	GYS1 GYS	DAAQGyRyPRPAsVPPsPsLsRHssPHQsEDEEDPRNGPLE
P13807	S653	SIGNOR\|iPTMNet\|EPSD\|PSP	GYS1 GYS	GyRyPRPAsVPPsPsLsRHssPHQsEDEEDPRNGPLEEDGE
P13929	S37	Sugiyama	ENO3	NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY
P13929	S40	Sugiyama	ENO3	VEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGK
P14314	T469	Sugiyama	PRKCSH G19P1	WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618	T328	EPSD\|PSP	PKM OIP3 PK2 PK3 PKM2	LAQKMMIGRCNRAGKPVICAtQMLEsMIKKPRPTRAEGsDV
P14866	S101	Sugiyama	HNRNPL HNRPL P/OKcl.14	GAAGGGGGGENyDDPHKtPAsPVVHIRGLIDGVVEADLVEA
P14921	S269	SIGNOR\|PSP	ETS1 EWSR2	QDsFEsIEsYDSCDRLtQsWssQssFNsLQRVPsyDsFDsE
P14921	T265	SIGNOR\|PSP	ETS1 EWSR2	KLGGQDsFEsIEsYDSCDRLtQsWssQssFNsLQRVPsyDs
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15559	S82	Sugiyama	NQO1 DIA4 NMOR1	DPANFQYPAESVLAYKEGHLsPDIVAEQKKLEAADLVIFQF
P15924	S2845	EPSD\|PSP	DSP	sRsGsRsGsRSGsRsGsRsGsRRGsFDAtGNssYsYSYSFS
P15924	S2849	EPSD\|PSP	DSP	sRsGsRSGsRsGsRsGsRRGsFDAtGNssYsYSYSFSsssI
P15941	S1227	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	MUC1 PUM	sEyPtyHtHGRyVPPsstDRsPyEKVsAGNGGssLsytNPA
P16220	S115	PSP	CREB1	EDsQEsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVP
P16220	S129	SIGNOR\|ELM\|iPTMNet\|EPSD	CREB1	KRREILsRRPsYRKILNDLssDAPGVPRIEEEKsEEETSAP
P16278	S433	Sugiyama	GLB1 ELNR1	YGFVLYRTTLPQDCSNPAPLssPLNGVHDRAyVAVDGIPQG
P16401	T11	GPS6\|SIGNOR\|EPSD\|PSP	H1-5 H1F5 HIST1H1B	__________MsEtAPAEtAtPAPVEKsPAKKKATKKAAGA
P16615	S663	SIGNOR	ATP2A2 ATP2B	QDEDVTSKAFtGREFDELNPsAQRDACLNARCFARVEPSHK
P17275	S251	SIGNOR\|EPSD\|PSP	JUNB	GLGRGASTFKEEPQtVPEARsRDAtPPVsPINMEDQERIKV
P17275	T255	SIGNOR\|EPSD\|PSP	JUNB	GASTFKEEPQtVPEARsRDAtPPVsPINMEDQERIKVERKR
P17661	S28	PSP	DES	sQRVssYRRtFGGAPGFPLGsPLssPVFPRAGFGsKGssss
P17661	S32	PSP	DES	ssYRRtFGGAPGFPLGsPLssPVFPRAGFGsKGssssVTSR
P17676	S223	EPSD\|PSP	CEBPB TCF5 PP9092	FPYALRAYLGYQAVPsGssGsLstsssssPPGtPsPADAKA
P17676	S231	SIGNOR	CEBPB TCF5 PP9092	LGYQAVPsGssGsLstsssssPPGtPsPADAKAPPTACyAG
P17676	T226	SIGNOR	CEBPB TCF5 PP9092	ALRAYLGYQAVPsGssGsLstsssssPPGtPsPADAKAPPT
P17676	T235	SIGNOR	CEBPB TCF5 PP9092	AVPsGssGsLstsssssPPGtPsPADAKAPPTACyAGAAPA
P17812	S571	SIGNOR\|PSP	CTPS1 CTPS	LSHYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD
P17812	S573	Sugiyama	CTPS1 CTPS	HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P17812	S574	SIGNOR\|Sugiyama	CTPS1 CTPS	YLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD___
P17812	S575	SIGNOR	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P17947	S140	SIGNOR\|PSP	SPI1	QYPSLSPAQPSSDEEEGERQsPPLEVSDGEADGLEPGPGLL
P17947	S41	SIGNOR\|PSP	SPI1	VPYDTDLYQRQTHEYYPYLSsDGESHSDHYWDFHPHHVHSE
P18669	S23	Sugiyama	PGAM1 PGAMA CDABP0006	AYKLVLIRHGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQ
P18669	S31	Sugiyama	PGAM1 PGAMA CDABP0006	HGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALRDAGyE
P18669	Y26	Sugiyama	PGAM1 PGAMA CDABP0006	LVLIRHGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALR
P19544	S208	SIGNOR	WT1	LGEQQYSVPPPVYGCHTPTDsCTGSQALLLRTPYSSDNLYQ
P19793	S49	SIGNOR\|EPSD\|PSP	RXRA NR2B1	AAPsLHPSLGPGIGSPGQLHsPISTLSSPINGMGPPFsVIS
P19793	S66	SIGNOR\|EPSD\|PSP	RXRA NR2B1	QLHsPISTLSSPINGMGPPFsVISSPMGPHSMsVPTtPTLG
P19793	S78	SIGNOR\|EPSD\|PSP	RXRA NR2B1	INGMGPPFsVISSPMGPHSMsVPTtPTLGFSTGSPQLSSPM
P19838	S903	GPS6\|SIGNOR\|ELM\|EPSD	NFKB1	EAIEVIQAAssPVKTtsQAHsLPLsPAstRQQIDELRDSDs
P19838	S907	GPS6\|SIGNOR\|ELM\|EPSD	NFKB1	VIQAAssPVKTtsQAHsLPLsPAstRQQIDELRDSDsVCDs
P20393	S55	SIGNOR\|EPSD\|PSP	NR1D1 EAR1 HREV THRAL	DNSNGSFQSLTQGCPTYFPPsPTGsLTQDPARSFGSIPPSL
P20393	S59	SIGNOR\|EPSD\|PSP	NR1D1 EAR1 HREV THRAL	GSFQSLTQGCPTYFPPsPTGsLTQDPARSFGSIPPSLSDDG
P21796	S13	PSP	VDAC1 VDAC	________MAVPPTYADLGKsARDVFTKGyGFGLIKLDLKt
P21796	T107	PSP	VDAC1 VDAC	VEDQLARGLKLtFDssFsPNtGKKNAKIKTGYKREHINLGC
P22234	S27	Sugiyama	PAICS ADE2 AIRC PAIS	LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22314	S816	Sugiyama	UBA1 A1S9T UBE1	VPEFtPKsGVKIHVsDQELQsANAsVDDsRLEELKATLPsP
P22314	S820	Sugiyama	UBA1 A1S9T UBE1	tPKsGVKIHVsDQELQsANAsVDDsRLEELKATLPsPDKLP
P22392	Y151	Sugiyama	NME2 NM23B	SLWFKPEELVDyKSCAHDWVyE___________________
P22415	S186	SIGNOR\|PSP	USF1 BHLHB11 USF	PQEVLQGGSQRSIAPRTHPYsPKSEAPRTTRDEKRRAQHNE
P22415	T153	SIGNOR\|PSP	USF1 BHLHB11 USF	SGSTAAVVTTQGSEALLGQAtPPGTGQFFVMMSPQEVLQGG
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626	S212	Sugiyama	HNRNPA2B1 HNRPA2B1	EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P22626	Y347	Sugiyama	HNRNPA2B1 HNRPA2B1	MGGPyGGGNyGPGGsGGsGGyGGRsRy______________
P22670	S120	EPSD\|PSP	RFX1	YIVVTVSEGAMRAsEtVsEAsPGstAsQtGVPTQVVQQVQG
P22670	T124	EPSD\|PSP	RFX1	TVSEGAMRAsEtVsEAsPGstAsQtGVPTQVVQQVQGTQQR
P23246	T687	SIGNOR\|EPSD\|PSP	SFPQ PSF	FGQGGAGPVGGQGPRGMGPGtPAGyGRGREEYEGPNKKPRF
P24071	S284	SIGNOR\|PSP	FCAR CD89	AEPSWSQQMCQPGLTFARTPsVCK_________________
P24385	T286	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CCND1 BCL1 PRAD1	MDPKAAEEEEEEEEEVDLACtPtDVRDVDI___________
P24864	S73	EPSD\|PSP	CCNE1 CCNE	ARDQCGSQPWDNNAVCADPCsLIPtPDKEDDDRVYPNsTCK
P24864	T395	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CCNE1 CCNE	AKKAMLsEQNRAsPLPsGLLtPPQsGKKQSSGPEMA_____
P24864	T77	SIGNOR\|EPSD\|PSP	CCNE1 CCNE	CGSQPWDNNAVCADPCsLIPtPDKEDDDRVYPNsTCKPRII
P25054	S1501	iPTMNet\|EPSD\|PSP	APC DP2.5	VLPDADTLLHFATESTPDGFsCsssLsALsLDEPFIQKDVE
P25054	S1503	iPTMNet\|EPSD\|PSP	APC DP2.5	PDADTLLHFATESTPDGFsCsssLsALsLDEPFIQKDVELR
P25205	T722	Sugiyama	MCM3	GDsyDPyDFsDtEEEMPQVHtPKTADsQEtKEsQKVELsES
P25786	Y6	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	_______________MFRNQyDNDVtVWsPQGRIHQIEYAM
P26358	S714	PSP	DNMT1 AIM CXXC9 DNMT	MAMKEADDDEEVDDNIPEMPsPKKMHQGKKKKQNKNRIsWV
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27824	S362	Sugiyama	CANX	WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P29401	S295	Sugiyama	TKT	ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29401	T287	Sugiyama	TKT	AEQIIQEIysQIQsKKKILAtPPQEDAPsVDIANIRMPsLP
P29692	S71	Sugiyama	EEF1D EF1D	ARARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVEN
P30043	Y194	Sugiyama	BLVRB FLR SCAN	RVISKHDLGHFMLRCLttDEyDGHstyPsHQyQ________
P30101	S443	Sugiyama	PDIA3 ERP57 ERP60 GRP58	LsKDPNIVIAKMDAtANDVPsPyEVRGFPtIyFsPANKKLN
P30279	T280	SIGNOR\|EPSD\|PSP	CCND2	QYRQDQRDGsKsEDELDQAstPTDVRDIDL___________
P30281	T283	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	CCND3	ssPAPKAPRGsssQGPsQtstPtDVtAIHL___________
P30291	S211	SIGNOR\|EPSD\|PSP	WEE1	PKSLLSKARGIDSSSVKLRGssLFMDtEKSGKREFDVRQTP
P30304	S76	SIGNOR\|EPSD\|PSP	CDC25A	GSDyEQPLEVKNNSNLQRMGsSEstDsGFCLDsPGPLDSKE
P30405	S191	SIGNOR\|PSP	PPIF CYP3	FGHVKEGMDVVKKIESFGSKsGRTSKKIVItDCGQLs____
P31645	S48	PSP	SLC6A4 HTT SERT	QKVVPTPGDKVESGQISNGysAVPSPGAGDDtRHsIPATTT
P31943	S104	Sugiyama	HNRNPH1 HNRPH HNRPH1	EVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P31943	T100	Sugiyama	HNRNPH1 HNRPH HNRPH1	HRyVEVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPF
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P32929	S56	Sugiyama	CTH	AVVPPISLSTTFKQGAPGQHsGFEysRsGNPTRNCLEKAVA
P33076	S373	SIGNOR\|EPSD\|PSP	CIITA MHC2TA	PAGPDGILVEVDLVQARLERsSSKSLERELATPDWAERQLA
P34931	T39	Sugiyama	HSPA1L	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34931	T40	Sugiyama	HSPA1L	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P34931	Y43	Sugiyama	HSPA1L	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P34932	S31	Sugiyama	HSPA4 APG2 HSPH2	QSCYVAVARAGGIETIANEysDRCtPACIsFGPKNRSIGAA
P34932	S40	Sugiyama	HSPA4 APG2 HSPH2	AGGIETIANEysDRCtPACIsFGPKNRSIGAAAKSQVISNA
P34932	T35	Sugiyama	HSPA4 APG2 HSPH2	VAVARAGGIETIANEysDRCtPACIsFGPKNRSIGAAAKSQ
P34932	T538	Sugiyama	HSPA4 APG2 HSPH2	EEEKMQVDQEEPHVEEQQQQtPAENKAEsEEMEtsQAGsKD
P34932	Y30	Sugiyama	HSPA4 APG2 HSPH2	FQSCYVAVARAGGIETIANEysDRCtPACIsFGPKNRSIGA
P35222	S23	GPS6\|EPSD	CTNNB1 CTNNB OK/SW-cl.35 PRO2286	tQADLMELDMAMEPDRKAAVsHWQQQsyLDsGIHsGATtTA
P35222	S29	GPS6\|EPSD	CTNNB1 CTNNB OK/SW-cl.35 PRO2286	ELDMAMEPDRKAAVsHWQQQsyLDsGIHsGATtTAPsLsGK
P35222	S33	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CTNNB1 CTNNB OK/SW-cl.35 PRO2286	AMEPDRKAAVsHWQQQsyLDsGIHsGATtTAPsLsGKGNPE
P35222	S37	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CTNNB1 CTNNB OK/SW-cl.35 PRO2286	DRKAAVsHWQQQsyLDsGIHsGATtTAPsLsGKGNPEEEDV
P35222	T41	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CTNNB1 CTNNB OK/SW-cl.35 PRO2286	AVsHWQQQsyLDsGIHsGATtTAPsLsGKGNPEEEDVDTsQ
P35579	S1714	Sugiyama	MYH9	RAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQL
P35612	S613	EPSD\|PSP	ADD2 ADDB	PAKsAPAsPVQsPAKEAEtKsPLVsPsKSLEEGTKKTETSK
P35612	S693	EPSD\|PSP	ADD2 ADDB	ADtDVDTSKDKTESVTSGPMsPEGsPsKsPsKKKKKFRTPs
P35659	T67	SIGNOR	DEK	EKEKsLIVEGKREKKKVERLtMQVssLQREPFTIAQGKGQK
P35869	S436	SIGNOR\|PSP	AHR BHLHE76	ATNPFPAIMDPLPLRTKNGTsGKDsATTsTLSKDSLNPSSL
P35869	S440	SIGNOR\|PSP	AHR BHLHE76	FPAIMDPLPLRTKNGTsGKDsATTsTLSKDSLNPSSLLAAM
P35869	S444	SIGNOR\|PSP	AHR BHLHE76	MDPLPLRTKNGTsGKDsATTsTLSKDSLNPSSLLAAMMQQD
P35869	S689	SIGNOR\|PSP	AHR BHLHE76	PQQYNVFTDLHGISQEFPYKsEMDsMPYtQNFISCNQPVLP
P35869	S693	SIGNOR\|PSP	AHR BHLHE76	NVFTDLHGISQEFPYKsEMDsMPYtQNFISCNQPVLPQHSK
P35869	S723	SIGNOR\|PSP	AHR BHLHE76	CNQPVLPQHSKCTELDYPMGsFEPsPYPtTSSLEDFVTCLQ
P35869	S727	SIGNOR\|PSP	AHR BHLHE76	VLPQHSKCTELDYPMGsFEPsPYPtTSSLEDFVTCLQLPEN
P35869	T697	SIGNOR\|PSP	AHR BHLHE76	DLHGISQEFPYKsEMDsMPYtQNFISCNQPVLPQHSKCTEL
P35869	T731	SIGNOR\|PSP	AHR BHLHE76	HSKCTELDYPMGsFEPsPYPtTSSLEDFVTCLQLPENQKHG
P35998	T193	Sugiyama	PSMC2 MSS1	TYSDVGGCKEQIEKLREVVEtPLLHPERFVNLGIEPPKGVL
P36956	S430	SIGNOR\|EPSD\|PSP	SREBF1 BHLHD1 SREBP1	TDVLMEGVKTEVEDTLtPPPsDAGsPFQSsPLSLGSRGsGs
P36956	S434	SIGNOR\|EPSD\|PSP	SREBF1 BHLHD1 SREBP1	MEGVKTEVEDTLtPPPsDAGsPFQSsPLSLGSRGsGsGGsG
P36956	T426	SIGNOR\|EPSD\|PSP	SREBF1 BHLHD1 SREBP1	SGGNTDVLMEGVKTEVEDTLtPPPsDAGsPFQSsPLSLGSR
P37802	S145	Sugiyama	TAGLN2 KIAA0120 CDABP0035	VQRTLMNLGGLAVARDDGLFsGDPNWFPKKSKENPRNFsDN
P37840	S129	EPSD\|PSP	SNCA NACP PARK1	QEGILEDMPVDPDNEAyEMPsEEGyQDyEPEA_________
P38646	T86	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38646	T87	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P38936	S114	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1	RPGtsPALLQGTAEEDHVDLsLSCTLVPRsGEQAEGsPGGP
P38936	T57	GPS6\|ELM\|EPSD\|PSP	CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1	LMAGCIQEARERWNFDFVtEtPLEGDFAWERVRGLGLPKLy
P40337	S68	EPSD\|PSP	VHL	LGAEEEMEAGRPRPVLRSVNsREPsQVIFCNRsPRVVLPVW
P40763	S727	PSP	STAT3 APRF	KTKFICVtPttCsNtIDLPMsPRTLDSLMQFGNNGEGAEPS
P40763	T714	PSP	STAT3 APRF	HPEADPGsAAPyLKTKFICVtPttCsNtIDLPMsPRTLDSL
P41091	T109	Sugiyama	EIF2S3 EIF2G	YKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLVRH
P41236	T73	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PPP1R2 IPP2	LAtyHPADKDyGLMKIDEPstPYHsMMGDDEDACsDtEAtE
P46013	S1131	Sugiyama	MKI67	tPGPsEEsMtDEKTTKIACKsPPPEsVDtPtstKQWPKRSL
P46777	Y226	Sugiyama	RPL5 MSTP030	DyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAA
P46937	T114	Sugiyama	YAP1 YAP65	sFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQL
P46937	T119	Sugiyama	YAP1 YAP65	PEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQLGAVsP
P47736	S525	GPS6\|ELM\|EPSD	RAP1GAP KIAA0474 RAP1GA1	NIQEVQEKREsPPAGQKtPDsGHVSQEPKSENSStQssPEM
P48436	T236	EPSD\|PSP	SOX9	SGMSEVHsPGEHsGQsQGPPtPPtTPKTDVQPGKADLKREG
P49327	T1999	Sugiyama	FASN FAS	LLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFVVF
P49327	T2204	Sugiyama	FASN FAS	LRKLQELSSKADEAsELACPtPKEDGLAQQQtQLNLRSLLV
P49715	T226	SIGNOR\|iPTMNet\|EPSD	CEBPA CEBP	LQFQIAHCGQTTMHLQPGHPtPPPtPVPsPHPAPALGAAGL
P49715	T230	SIGNOR\|iPTMNet\|EPSD	CEBPA CEBP	IAHCGQTTMHLQPGHPtPPPtPVPsPHPAPALGAAGLPGPG
P49716	S167	EPSD\|PSP	CEBPD	VSLAAAGQPTPPTSPEPPRSsPRQtPAPGPAREKSAGKRGP
P49716	T171	PSP	CEBPD	AAGQPTPPTSPEPPRSsPRQtPAPGPAREKSAGKRGPDRGs
P49768	S353	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PSEN1 AD3 PS1 PSNL1	DGGFsEEWEAQRDsHLGPHRstPEsRAAVQELsssILAGED
P49768	S357	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PSEN1 AD3 PS1 PSNL1	sEEWEAQRDsHLGPHRstPEsRAAVQELsssILAGEDPEER
P49768	S397	GPS6	PSEN1 AD3 PS1 PSNL1	RGVKLGLGDFIFYSVLVGKAsATASGDWNTTIACFVAILIG
P49840	S282	Sugiyama	GSK3A	CDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTSSID
P49840	Y279	Sugiyama	GSK3A	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841	S13	Sugiyama	GSK3B	________MSGRPRttsFAEsCKPVQQPsAFGsMKVSRDKD
P49841	S219	Sugiyama	GSK3B	CDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTSSID
P49841	S389	Sugiyama	GSK3B	SNPPLATILIPPHARIQAAAstPtNATAASDANTGDRGQTN
P49841	S9	Sugiyama	GSK3B	____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P49841	T390	Sugiyama	GSK3B	NPPLATILIPPHARIQAAAstPtNATAASDANTGDRGQTNN
P49841	Y216	SIGNOR\|EPSD\|PSP\|Sugiyama	GSK3B	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P50219	S77	SIGNOR	MNX1 HLXB9	sCsPASSEPPAAPADRLRAEsPsPPRLLAAHCALLPKPGFL
P50219	S79	SIGNOR	MNX1 HLXB9	sPASSEPPAAPADRLRAEsPsPPRLLAAHCALLPKPGFLGA
P50395	S396	Sugiyama	GDI2 RABGDIB	IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50895	S596	EPSD\|PSP	BCAM LU MSK19	GPCCRQRREKGAPPPGEPGLsHsGsEQPEQtGLLMGGAsGG
P50990	T398	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	RGstDNLMDDIERAVDDGVNtFKVLTRDKRLVPGGGAtEIE
P52565	T160	Sugiyama	ARHGDIA GDIA1	DKtDyMVGsYGPRAEEyEFLtPVEEAPKGMLARGsYsIKSR
P52565	Y156	Sugiyama	ARHGDIA GDIA1	GVKIDKtDyMVGsYGPRAEEyEFLtPVEEAPKGMLARGsYs
P52630	S381	SIGNOR\|PSP	STAT2	VSIDRNPPQLQGFRKFNILTsNQKtLtPEKGQsQGLIWDFG
P52630	S393	SIGNOR\|PSP	STAT2	FRKFNILTsNQKtLtPEKGQsQGLIWDFGYLtLVEQRSGGS
P52630	T385	SIGNOR\|PSP	STAT2	RNPPQLQGFRKFNILTsNQKtLtPEKGQsQGLIWDFGYLtL
P52789	T514	Sugiyama	HK2	EMERGLSKETHASAPVKMLPtYVCAtPDGTEKGDFLALDLG
P52789	T519	Sugiyama	HK2	LSKETHASAPVKMLPtYVCAtPDGTEKGDFLALDLGGTNFR
P52945	S268	SIGNOR	PDX1 IPF1 STF1	VPPAAPVAAREGRLPPGLSAsPQPssVAPRRPQEPR_____
P52945	S272	SIGNOR	PDX1 IPF1 STF1	APVAAREGRLPPGLSAsPQPssVAPRRPQEPR_________
P52945	S61	SIGNOR	PDX1 IPF1 STF1	QPPPPPPHPFPGALGALEQGsPPDIsPYEVPPLADDPAVAH
P52945	S66	SIGNOR	PDX1 IPF1 STF1	PPHPFPGALGALEQGsPPDIsPYEVPPLADDPAVAHLHHHL
P52948	S623	Sugiyama	NUP98 ADAR2	KNLNNsNLFsPVNRDsENLAsPsEyPENGERFsFLSKPVDE
P53396	S451	SIGNOR\|ELM\|iPTMNet\|EPSD	ACLY	AAHTANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAK
P53396	S457	Sugiyama	ACLY	FLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQD
P53396	T447	SIGNOR\|ELM\|iPTMNet\|EPSD	ACLY	QPPTAAHTANFLLNAsGststPAPsRtAsFsEsRADEVAPA
P53805	S163	SIGNOR\|iPTMNet\|EPSD\|PSP	RCAN1 ADAPT78 CSP1 DSC1 DSCR1	TLHIGSSHLAPPNPDKQFLIsPPAsPPVGWKQVEDAtPVIN
P54132	S175	SIGNOR	BLM RECQ2 RECQL3	DDMDDFDTSETSKsFVtPPQsHFVRVStAQKSKKGKRNFFK
P54132	T171	SIGNOR\|EPSD\|PSP	BLM RECQ2 RECQL3	INDWDDMDDFDTSETSKsFVtPPQsHFVRVStAQKSKKGKR
P54252	S256	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	ATXN3 ATX3 MJD MJD1 SCA3	sRQEIDMEDEEADLRRAIQLsMQGssRNIsQDMtQtsGTNL
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652	T38	Sugiyama	HSPA2	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P54652	T39	Sugiyama	HSPA2	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P54652	Y42	Sugiyama	HSPA2	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55060	S342	Sugiyama	CSE1L CAS XPO2	ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF
P55795	S104	Sugiyama	HNRNPH2 FTP3 HNRPH2	EVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P55795	T100	Sugiyama	HNRNPH2 FTP3 HNRPH2	HRyVEVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPF
P56524	S298	SIGNOR\|EPSD\|PSP	HDAC4 KIAA0288	TALKKRPLDVTDSACSSAPGsGPSsPNNSSGSVSAENGIAP
P56524	S302	SIGNOR\|EPSD\|PSP	HDAC4 KIAA0288	KRPLDVTDSACSSAPGsGPSsPNNSSGSVSAENGIAPAVPS
P56537	S235	GPS6\|PSP	EIF6 EIF3A ITGB4BP OK/SW-cl.27	LSVVESVFKLNEAQPstIAtsMRDsLIDsLt__________
P56537	S239	GPS6\|PSP	EIF6 EIF3A ITGB4BP OK/SW-cl.27	ESVFKLNEAQPstIAtsMRDsLIDsLt______________
P56537	S243	GPS6\|PSP	EIF6 EIF3A ITGB4BP OK/SW-cl.27	KLNEAQPstIAtsMRDsLIDsLt__________________
P56537	T231	GPS6\|PSP	EIF6 EIF3A ITGB4BP OK/SW-cl.27	TSTELSVVESVFKLNEAQPstIAtsMRDsLIDsLt______
P57059	T182	GPS6\|EPSD	SIK1 SIK SNF1LK	DIKLADFGFGNFYKSGEPLStWCGsPPYAAPEVFEGKEYEG
P58012	S33	EPSD\|PSP	FOXL2	GALLAPETGRTVKEPEGPPPsPGKGGGGGGGTAPEKPDPAQ
P60174	T217	Sugiyama	TPI1 TPI	VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174	Y209	Sugiyama	TPI1 TPI	LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60484	S362	GPS6\|ELM\|EPSD\|PSP	PTEN MMAC1 TEP1	KVKLYFTKTVEEPSNPEASSsTSVtPDVsDNEPDHyRYsDt
P60484	T366	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	PTEN MMAC1 TEP1	YFTKTVEEPSNPEASSsTSVtPDVsDNEPDHyRYsDttDsD
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S239	Sugiyama	ACTB	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709	Y362	Sugiyama	ACTB	GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P61247	S263	Sugiyama	RPS3A FTE1 MFTL	GDEtGAKVERADGyEPPVQEsV___________________
P61978	S77	Sugiyama	HNRNPK HNRPK	VIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIETI
P61981	S38	Sugiyama	YWHAG	ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62195	T109	Sugiyama	PSMC5 SUG1	VHPEGKFVVDVDKNIDINDVtPNCRVALRNDsytLHKILPN
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736	S241	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62826	T21	Sugiyama	RAN ARA24 OK/SW-cl.81	MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P62826	T66	Sugiyama	RAN ARA24 OK/SW-cl.81	EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62942	S9	Sugiyama	FKBP1A FKBP1 FKBP12	____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S239	Sugiyama	ACTG1 ACTG	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261	Y362	Sugiyama	ACTG1 ACTG	GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P63267	S240	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032	S241	Sugiyama	ACTC1 ACTC	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133	S241	Sugiyama	ACTA1 ACTA	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	T82	Sugiyama	TUBA1B	VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
P84022	T66	SIGNOR	SMAD3 MADH3	GQLDELEKAITTQNVNTKCItIPRSLDGRLQVSHRKGLPHV
P84098	T29	Sugiyama	RPL19	RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
P98170	T180	SIGNOR\|EPSD\|PSP	XIAP API3 BIRC4 IAP3	MYSEEARLKSFQNWPDYAHLtPRELASAGLYYTGIGDQVQC
Q00613	S303	SIGNOR\|ELM\|EPSD\|PSP	HSF1 HSTF1	SIDERPLSSsPLVRVKEEPPsPPQsPRVEEAsPGRPssVDt
Q00653	S222	EPSD\|PSP	NFKB2 LYT10	DGSFSLPLKPVISQPIHDsKsPGASNLKISRMDKTAGSVRG
Q00653	S707	EPSD\|PSP	NFKB2 LYT10	LLKAGADIHAENEEPLCPLPsPPTsDsDsDsEGPEKDtRss
Q00653	S711	EPSD\|PSP	NFKB2 LYT10	GADIHAENEEPLCPLPsPPTsDsDsDsEGPEKDtRssFRGH
Q01094	S403	EPSD\|PSP	E2F1 RBBP3	LLEHVREDFSGLLPEEFISLsPPHEALDYHFGLEEGEGIRD
Q01094	T433	EPSD\|PSP	E2F1 RBBP3	FGLEEGEGIRDLFDCDFGDLtPLDF________________
Q01201	S573	EPSD\|PSP	RELB	VGSNMFPNHYREAAFGGGLLsPGPEAT______________
Q01518	S308	SIGNOR\|PSP	CAP1 CAP	AQSGPVRsGPKPFsAPKPQtsPsPKRATKKEPAVLELEGKK
Q01518	S310	SIGNOR\|PSP	CAP1 CAP	SGPVRsGPKPFsAPKPQtsPsPKRATKKEPAVLELEGKKWR
Q01974	S864	SIGNOR	ROR2 NTRKR2	MQMAPQQVPPQMVPKPssHHsGsGststGYVTTAPSNTSMA
Q02156	S346	SIGNOR\|EPSD\|PSP	PRKCE PKCE	GAEsPQPAsGssPsEEDRsKsAPtsPCDQEIKELENNIRKA
Q02543	T24	Sugiyama	RPL18A	SGTLREYKVVGRCLPTPKCHtPPLYRMRIFAPNHVVAKSRF
Q04206	S468	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	RELA NFKB3	EDLGALLGNSTDPAVFTDLAsVDNsEFQQLLNQGIPVAPHT
Q04206	T254	SIGNOR	RELA NFKB3	EARGsFSQADVHRQVAIVFRtPPYADPsLQAPVRVsMQLRR
Q04637	S1430	Sugiyama	EIF4G1 EIF4F EIF4G EIF4GI	GQDIGAFVAEQKVEyTLGEEsEAPGQRALPsEELNRQLEKL
Q04721	S2070	SIGNOR\|iPTMNet\|EPSD	NOTCH2	ARDRMHHDIVRLLDEyNVtPsPPGtVLtSALsPVICGPNRs
Q04721	S2093	SIGNOR\|iPTMNet\|EPSD	NOTCH2	GtVLtSALsPVICGPNRsFLsLKHtPMGKKSRRPSAKSTMP
Q04721	T2068	SIGNOR\|iPTMNet\|EPSD	NOTCH2	DVARDRMHHDIVRLLDEyNVtPsPPGtVLtSALsPVICGPN
Q04721	T2074	SIGNOR\|iPTMNet\|EPSD	NOTCH2	MHHDIVRLLDEyNVtPsPPGtVLtSALsPVICGPNRsFLsL
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q07021	T165	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	GEEEPSQGQKVEEQEPELtstPNFVVEVIKNDDGKKALVLD
Q07812	S163	SIGNOR\|EPSD\|PSP	BAX BCL2L4	FLRERLLGWIQDQGGWDGLLsYFGtPTWQtVtIFVAGVLTA
Q07817	S62	EPSD\|PSP	BCL2L1 BCL2L BCLX	ESEMEtPsAINGNPSWHLADsPAVNGATGHSSSLDAREVIP
Q07820	S121	PSP	MCL1 BCL2L3	PTRRAAPLEEMEAPAADAIMsPEEELDGYEPEPLGKRPAVL
Q07820	S159	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MCL1 BCL2L3	AVLPLLELVGEsGNNtstDGsLPstPPPAEEEEDELYRQSL
Q07820	T163	iPTMNet\|EPSD\|PSP	MCL1 BCL2L3	LLELVGEsGNNtstDGsLPstPPPAEEEEDELYRQSLEIIS
Q07960	S51	Sugiyama	ARHGAP1 CDC42GAP RHOGAP1	KNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDIARHQ
Q08J23	S743	Sugiyama	NSUN2 SAKI TRM4	AstGQPDNDVtEGQRAGEPNsPDAEEANsPDVtAGCDPAGV
Q12778	S325	iPTMNet\|EPSD	FOXO1 FKHR FOXO1A	DDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLGEGDVHS
Q12931	S568	Sugiyama	TRAP1 HSP75 HSPC5	ISVETDIVVDHYKEEKFEDRsPAAECLSEKETEELMAWMRN
Q13131	S486	EPSD\|PSP	PRKAA1 AMPK1	DsRTYLLDFRsIDDEItEAKsGtAtPQRsGsVsNYRSCQRs
Q13131	T482	PSP	PRKAA1 AMPK1	LYQVDsRTYLLDFRsIDDEItEAKsGtAtPQRsGsVsNYRS
Q13131	T490	EPSD\|PSP	PRKAA1 AMPK1	YLLDFRsIDDEItEAKsGtAtPQRsGsVsNYRSCQRsDsDA
Q13136	S666	Sugiyama	PPFIA1 LIP1	IQEEKENTEQRAEEIESRVGsGsLDNLGRFRSMssIPPYPA
Q13144	S535	SIGNOR\|ELM\|iPTMNet\|EPSD	EIF2B5 EIF2BE	WGLKINMEEEsEsESEQSMDsEEPDsRGGsPQMDDIKVFQN
Q13144	S540	SIGNOR\|iPTMNet\|EPSD	EIF2B5 EIF2BE	NMEEEsEsESEQSMDsEEPDsRGGsPQMDDIKVFQNEVLGT
Q13144	S544	iPTMNet\|EPSD	EIF2B5 EIF2BE	EsEsESEQSMDsEEPDsRGGsPQMDDIKVFQNEVLGTLQRG
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13451	T46	Sugiyama	FKBP5 AIG6 FKBP51	TsKKDRGVLKIVKRVGNGEEtPMIGDKVyVHYKGKLSNGKK
Q13485	T265	SIGNOR\|PSP	SMAD4 DPC4 MADH4	QPGQQQNGFTGQPATYHHNStTTWtGSRtAPYtPNLPHHQN
Q13485	T269	SIGNOR\|PSP	SMAD4 DPC4 MADH4	QQNGFTGQPATYHHNStTTWtGSRtAPYtPNLPHHQNGHLQ
Q13485	T273	SIGNOR\|PSP	SMAD4 DPC4 MADH4	FTGQPATYHHNStTTWtGSRtAPYtPNLPHHQNGHLQHHPP
Q13509	S168	Sugiyama	TUBB3 TUBB4	GTLLISKVREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLS
Q13509	S172	Sugiyama	TUBB3 TUBB4	ISKVREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLSIHQL
Q13509	S75	Sugiyama	TUBB3 TUBB4	SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13541	S65	EPSD\|PSP	EIF4EBP1	ttPGGtRIIyDRKFLMECRNsPVtKtPPRDLPtIPGVtsPs
Q13541	T37	SIGNOR\|EPSD\|PSP	EIF4EBP1	ATRRVVLGDGVQLPPGDysttPGGtLFsttPGGtRIIyDRK
Q13541	T46	SIGNOR\|EPSD\|PSP	EIF4EBP1	GVQLPPGDysttPGGtLFsttPGGtRIIyDRKFLMECRNsP
Q13541	T70	EPSD\|PSP	EIF4EBP1	tRIIyDRKFLMECRNsPVtKtPPRDLPtIPGVtsPssDEPP
Q13765	T159	GPS6\|ELM	NACA HSD48	AAEKFKVQGEAVsNIQENTQtPTVQEEsEEEEVDEtGVEVK
Q13885	S75	Sugiyama	TUBB2A TUBB2	AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q13887	S303	SIGNOR\|EPSD\|PSP	KLF5 BTEB2 CKLF IKLF	PCTYTMPSQFLPQQATYFPPsPPSSEPGSPDRQAEMLQNLt
Q14103	S83	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	HNRNPD AUF1 HNRPD	SEGAKIDAsKNEEDEGHsNssPRHsEAAtAQREEWKMFIGG
Q14103	T193	Sugiyama	HNRNPD AUF1 HNRPD	KAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVESIEL
Q14194	S518	SIGNOR	CRMP1 DPYSL1 ULIP3	MYDGPVyEVPAtPKYAtPAPsAKssPsKHQPPPIRNLHQSN
Q14194	T509	SIGNOR	CRMP1 DPYSL1 ULIP3	FGLQGVSRGMYDGPVyEVPAtPKYAtPAPsAKssPsKHQPP
Q14194	T514	SIGNOR	CRMP1 DPYSL1 ULIP3	VSRGMYDGPVyEVPAtPKYAtPAPsAKssPsKHQPPPIRNL
Q14195	S518	SIGNOR\|EPSD\|PSP	DPYSL3 CRMP4 DRP3 ULIP ULIP1	MYDGPVFDLtttPKGGtPAGsARGsPTRPNPPVRNLHQSGF
Q14195	S522	SIGNOR	DPYSL3 CRMP4 DRP3 ULIP ULIP1	PVFDLtttPKGGtPAGsARGsPTRPNPPVRNLHQSGFSLSG
Q14195	T509	SIGNOR\|EPSD\|PSP	DPYSL3 CRMP4 DRP3 ULIP ULIP1	ADLHAVPRGMYDGPVFDLtttPKGGtPAGsARGsPTRPNPP
Q14195	T514	SIGNOR\|EPSD\|PSP	DPYSL3 CRMP4 DRP3 ULIP ULIP1	VPRGMYDGPVFDLtttPKGGtPAGsARGsPTRPNPPVRNLH
Q14249	S288	PSP	ENDOG	ESIERASGLLFVPNILARAGsLKAITAGSK___________
Q14249	T128	PSP	ENDOG	GDRRECDFREDDSVHAYHRAtNADYRGSGFDRGHLAAAANH
Q14449	S358	SIGNOR\|PSP	GRB14	RLLKYGMQLYQNYMHPYQGRsGCSsQSIsPMRsIsENSLVA
Q14449	S362	SIGNOR\|PSP	GRB14	YGMQLYQNYMHPYQGRsGCSsQSIsPMRsIsENSLVAMDFS
Q14449	S366	SIGNOR\|PSP	GRB14	LYQNYMHPYQGRsGCSsQSIsPMRsIsENSLVAMDFSGQKS
Q14449	S370	PSP	GRB14	YMHPYQGRsGCSsQSIsPMRsIsENSLVAMDFSGQKSRVIE
Q14449	S419	PSP	GRB14	AVEEGLAWRKKGCLRLGTHGsPtAsSQSSATNMAIHRSQPW
Q14449	S423	PSP	GRB14	GLAWRKKGCLRLGTHGsPtAsSQSSATNMAIHRSQPWFHHK
Q14494	S379	SIGNOR\|EPSD\|PSP	NFE2L1 HBZ17 NRF1 TCF11	QNVSLHQASLGGCSQDFLLFsPEVESLPVASSSTLLPLAPS
Q14534	S83	PSP	SQLE ERG1	FALFSDILSGLPFIGFFWAKsPPEsENKEQLEARRRRKGTN
Q14534	S87	PSP	SQLE ERG1	SDILSGLPFIGFFWAKsPPEsENKEQLEARRRRKGTNISET
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14596	T586	SIGNOR\|PSP	NBR1 1A13B KIAA0049 M17S2 MIG19	LDINIVQELERVPHNtPVDVtPCMsPLPHDsPLIEKPGLGQ
Q14653	S123	PSP	IRF3	PHKIYEFVNSGVGDFSQPDTsPDTNGGGSTSDtQEDILDEL
Q14653	S173	PSP	IRF3	PDPGPPSLAVAPEPCPQPLRsPsLDNPtPFPNLGPsENPLK
Q14653	T180	PSP	IRF3	LAVAPEPCPQPLRsPsLDNPtPFPNLGPsENPLKRLLVPGE
Q14896	S133	EPSD\|PSP	MYBPC3	ATGAPGEAPAPAAELGESAPsPKGSSSAALNGPTPGAPDDP
Q14896	S304	PSP	MYBPC3	sDSHEDTGILDFSSLLKKRDsFRTPRDsKLEAPAEEDVWEI
Q15208	S6	SIGNOR\|EPSD\|PSP	STK38 NDR1	_______________MAMTGstPCssMSNHTKERVTMTKVT
Q15208	T7	EPSD\|PSP	STK38 NDR1	______________MAMTGstPCssMSNHTKERVTMTKVTL
Q15293	T71	Sugiyama	RCN1 RCN	EDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRI
Q15293	T76	Sugiyama	RCN1 RCN	FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15691	S155	PSP	MAPRE1	tAVAPsLVAPALNKPKKPLtsssAAPQRPIstQRTAAAPKA
Q15691	S156	PSP	MAPRE1	AVAPsLVAPALNKPKKPLtsssAAPQRPIstQRTAAAPKAG
Q15746	S16	ELM	MYLK MLCK MLCK1 MYLK1	_____MGDVKLVASSHIsKTsLsVDPSRVDSMPLTEAPAFI
Q15746	S1776	EPSD\|PSP	MYLK MLCK MLCK1 MYLK1	GRLssMAMISGLSGRKsstGsPtsPLNAEKLEsEEDVsQAF
Q15773	S240	Sugiyama	MLF2	GGRRAEGPPRLAIQGPEDsPsRQsRRYDW____________
Q15797	T202	EPSD\|PSP	SMAD1 BSP1 MADH1 MADR1	HPFPHsPNSSYPNsPGSSSStYPHsPTSSDPGsPFQMPADT
Q15853	S155	EPSD\|PSP	USF2 BHLHB12	PGPAAPFPLAVIQNPFSNGGsPAAEAVSGEARFAYFPASSV
Q15853	T230	EPSD\|PSP	USF2 BHLHB12	TQRTIAPRTHPYsPKIDGTRtPRDERRRAQHNEVERRRRDK
Q15910	S363	EPSD\|PSP	EZH2 KMT6	IKtPPKRPGGRRRGRLPNNssRPstPtINVLEsKDtDsDRE
Q15910	T367	EPSD\|PSP	EZH2 KMT6	PKRPGGRRRGRLPNNssRPstPtINVLEsKDtDsDREAGtE
Q16204	S240	Sugiyama	CCDC6 D10S170 TST1	RMDKLEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMR
Q16204	S244	Sugiyama	CCDC6 D10S170 TST1	LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q16236	S344	EPSD\|PSP	NFE2L2 NRF2	LCKAFNQNHPESTAEFNDSDsGIsLNTsPSVAsPEHSVESS
Q16236	S347	EPSD\|PSP	NFE2L2 NRF2	AFNQNHPESTAEFNDSDsGIsLNTsPSVAsPEHSVESSSYG
Q16555	S518	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	DPYSL2 CRMP2 ULIP2	LyDGPVCEVsVtPKtVtPAssAKtsPAKQQAPPVRNLHQsG
Q16555	T509	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	DPYSL2 CRMP2 ULIP2	AELRGVPRGLyDGPVCEVsVtPKtVtPAssAKtsPAKQQAP
Q16555	T514	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	DPYSL2 CRMP2 ULIP2	VPRGLyDGPVCEVsVtPKtVtPAssAKtsPAKQQAPPVRNL
Q16584	S789	SIGNOR\|PSP	MAP3K11 MLK3 PTK1 SPRK	PsPLRSRIDPWsFVSAGPRPsPLPsPQPAPRRAPWTLFPDS
Q16584	S793	SIGNOR\|PSP	MAP3K11 MLK3 PTK1 SPRK	RSRIDPWsFVSAGPRPsPLPsPQPAPRRAPWTLFPDSDPFW
Q16630	T157	Sugiyama	CPSF6 CFIM68	SKKLMDLLPKRELHGQNPVVtPCNKQFLsQFEMQSRKTTQS
Q16665	S551	GPS6\|EPSD	HIF1A BHLHE78 MOP1 PASD8	FKLELVEKLFAEDTEAKNPFsTQDtDLDLEMLAPYIPMDDD
Q16665	S589	GPS6\|EPSD	HIF1A BHLHE78 MOP1 PASD8	DDDFQLRsFDQLSPLESSSAsPESASPQSTVTVFQQTQIQE
Q16665	T555	GPS6\|EPSD	HIF1A BHLHE78 MOP1 PASD8	LVEKLFAEDTEAKNPFsTQDtDLDLEMLAPYIPMDDDFQLR
Q16881	T413	Sugiyama	TXNRD1 GRIM12 KDRF	HGIKFIRQFVPIKVEQIEAGtPGRLRVVAQSTNSEEIIEGE
Q2M1Z3	T789	SIGNOR	ARHGAP31 CDGAP KIAA1204	VEVGGPGNLsPPLPPAPPPPtPLEESTPVLLSKGGPEREDS
Q53GS7	S88	PSP	GLE1 GLE1L	ETSPSSTSASALDQPSFVPKsPDAssAFsPAsPAtPNGTKG
Q53GS7	S92	PSP	GLE1 GLE1L	SSTSASALDQPSFVPKsPDAssAFsPAsPAtPNGTKGKDES
Q53GS7	S93	PSP	GLE1 GLE1L	STSASALDQPSFVPKsPDAssAFsPAsPAtPNGTKGKDESQ
Q53GS7	S99	PSP	GLE1 GLE1L	LDQPSFVPKsPDAssAFsPAsPAtPNGTKGKDESQHTESMV
Q53GS7	T102	PSP	GLE1 GLE1L	PSFVPKsPDAssAFsPAsPAtPNGTKGKDESQHTESMVLQS
Q562R1	S240	Sugiyama	ACTBL2	VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q5R3I4	S362	Sugiyama	TTC38	GAHDPQTTQELLTTLRDASEsPGENCQHLLARDVGLPLCQA
Q5T4S7	S178	Sugiyama	UBR4 KIAA0462 KIAA1307 RBAF600	AKLPQTVKTLSDVEDQKELAsPVsPELRQKEVQMNFLNQLT
Q6IA17	T372	GPS6\|PSP	SIGIRR UNQ301/PRO342	PEGDLGVRGPVFGEPSAPPHtsGVsLGEsRssEVDVSDLGS
Q6P3X3	T302	Sugiyama	TTC27	VAQLILDVRREGDVLSNCEFtPAPtPQEHLTKNLELNDDTI
Q6P3X3	T306	Sugiyama	TTC27	ILDVRREGDVLSNCEFtPAPtPQEHLTKNLELNDDTILNDI
Q6PGQ7	S274	SIGNOR\|EPSD\|PSP	BORA C13orf34	IQASAKKYSLGSITsPsPIssPTFsPIEFQIGETPLSEQRK
Q6PGQ7	S278	SIGNOR\|EPSD\|PSP	BORA C13orf34	AKKYSLGSITsPsPIssPTFsPIEFQIGETPLSEQRKFtVH
Q6R327	S1235	EPSD\|PSP	RICTOR KIAA1999	IRsQsFNtDtttSGIssMsssPsRETVGVDATTMDTDCGSM
Q6R327	T1695	SIGNOR\|EPSD\|PSP	RICTOR KIAA1999	ELFQDVQFLQMHEEAEAVLAtPPKQPIVDTSAEs_______
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3	S939	Sugiyama	POTEE A26C1A POTE2	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6S8J3	Y1062	Sugiyama	POTEE A26C1A POTE2	GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q6U7Q0	S391	SIGNOR\|EPSD\|PSP	ZNF322 ZNF322A ZNF388 ZNF489	TVHIGEKPFVCNVSEKGLELsPPHAsEAsQMS_________
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZMU5	S255	PSP	TRIM72 MG53	TEFLMKYCLVTSRLQKILAEsPPPARLDIQLPIISDDFKFQ
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	T82	Sugiyama	TUBA1A TUBA3	VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q7KZF4	T240	Sugiyama	SND1 TDRD11	TVMLSGIKCPTFRREADGsEtPEPFAAEAKFFTESRLLQRD
Q7KZI7	S212	SIGNOR\|EPSD\|PSP	MARK2 EMK1	ADFGFSNEFTFGNKLDtFCGsPPYAAPELFQGKKYDGPEVD
Q8IWX8	S817	Sugiyama	CHERP DAN26 SCAF6	QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8	T819	Sugiyama	CHERP DAN26 SCAF6	RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8IZQ8	S451	SIGNOR\|iPTMNet\|EPSD	MYOCD MYCD	PNYQSSSSTSALSNGFYHFGsTSSsPPIsPASsDLSVAGSL
Q8IZQ8	S455	SIGNOR\|iPTMNet\|EPSD	MYOCD MYCD	SSSSTSALSNGFYHFGsTSSsPPIsPASsDLSVAGSLPDTF
Q8IZQ8	S459	SIGNOR\|iPTMNet\|EPSD	MYOCD MYCD	TSALSNGFYHFGsTSSsPPIsPASsDLSVAGSLPDTFNDAS
Q8IZQ8	S463	SIGNOR	MYOCD MYCD	SNGFYHFGsTSSsPPIsPASsDLSVAGSLPDTFNDASPSFG
Q8IZQ8	S626	SIGNOR\|iPTMNet\|EPSD	MYOCD MYCD	LQPLGNAHCVESSDQTNVLSsTFLsPQCsPQHsPLGAVKSP
Q8IZQ8	S630	SIGNOR\|iPTMNet\|EPSD	MYOCD MYCD	GNAHCVESSDQTNVLSsTFLsPQCsPQHsPLGAVKSPQHIS
Q8IZQ8	S634	SIGNOR\|iPTMNet\|EPSD	MYOCD MYCD	CVESSDQTNVLSsTFLsPQCsPQHsPLGAVKSPQHISLPPS
Q8IZQ8	S638	SIGNOR	MYOCD MYCD	SDQTNVLSsTFLsPQCsPQHsPLGAVKSPQHISLPPSPNNP
Q8N122	S722	EPSD\|PSP	RPTOR KIAA1303 RAPTOR	GGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSLQNL
Q8N122	S792	EPSD\|PSP	RPTOR KIAA1303 RAPTOR	PENEEHILSFETIDKMRRAssYSSLNSLIGVSFNSVYTQIW
Q8N122	S859	EPSD\|PSP	RPTOR KIAA1303 RAPTOR	YKATVNARPQRVLDtssLtQsAPAsPtNKGVHIHQAGGsPP
Q8N122	S863	EPSD\|PSP	RPTOR KIAA1303 RAPTOR	VNARPQRVLDtssLtQsAPAsPtNKGVHIHQAGGsPPAsst
Q8N122	S877	EPSD\|PSP	RPTOR KIAA1303 RAPTOR	tQsAPAsPtNKGVHIHQAGGsPPAsstssssLtNDVAKQPV
Q8N1F7	S430	Sugiyama	NUP93 KIAA0095	TEDYLWLKLNQVCFDDDGTssPQDRLTLsQFQKQLLEDYGE
Q8N684	T203	Sugiyama	CPSF7	GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8NBJ5	S607	Sugiyama	COLGALT1 GLT25D1 PSEC0241	DRAKSQKMREQQALSREAKNsDVLQsPLDsAARDEL_____
Q8NBJ5	S612	Sugiyama	COLGALT1 GLT25D1 PSEC0241	QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8NHW3	S49	SIGNOR\|PSP	MAFA	FEVKKEPPEAERFCHRLPPGsLSStPLStPCSsVPSsPSFC
Q8NHW3	S61	SIGNOR\|PSP	MAFA	FCHRLPPGsLSStPLStPCSsVPSsPSFCAPSPGTGGGGGA
Q8NHW3	T53	SIGNOR\|PSP	MAFA	KEPPEAERFCHRLPPGsLSStPLStPCSsVPSsPSFCAPSP
Q8NHW3	T57	SIGNOR\|PSP	MAFA	EAERFCHRLPPGsLSStPLStPCSsVPSsPSFCAPSPGTGG
Q92837	S188	SIGNOR\|EPSD\|PSP	FRAT1	CRRGWLRGAAASRRLQQRRGsQPETRTGDDDPHRLLQQLVL
Q92908	S37	SIGNOR\|EPSD\|PSP	GATA6	AGADASDSRAFPAREPSTPPsPISSSSSSCSRGGERGPGGA
Q92915	S226	SIGNOR	FGF14 FHF4	YREPSLHDVGETVPKPGVTPsKsTsASAIMNGGKPVNKSKT
Q92993	S86	SIGNOR\|EPSD\|PSP	KAT5 HTATIP TIP60	KKIQFPKKEAKTPTKNGLPGsRPGsPEREVPASAQASGKTL
Q92993	S90	EPSD\|PSP	KAT5 HTATIP TIP60	FPKKEAKTPTKNGLPGsRPGsPEREVPASAQASGKTLPIPV
Q969R2	S762	PSP	OSBP2 KIAA1664 ORP4 OSBPL4	AHYVLSGSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSA
Q969R2	S763	PSP	OSBP2 KIAA1664 ORP4 OSBPL4	HYVLSGSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSAK
Q969R2	S766	PSP	OSBP2 KIAA1664 ORP4 OSBPL4	LSGSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSAKLLW
Q969R2	S768	PSP	OSBP2 KIAA1664 ORP4 OSBPL4	GSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSAKLLWKK
Q96A49	S269	Sugiyama	SYAP1 PRO3113	PPVVIKSQLKtQEDEEEIstsPGVsEFVsDAFDACNLNQED
Q96C19	S74	Sugiyama	EFHD2 SWS1	ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96D15	T72	Sugiyama	RCN3 UNQ239/PRO272	FQYDHEAFLGREVAKEFDQLtPEEsQARLGRIVDRMDRAGD
Q96EK9	S184	Sugiyama	KTI12 SBBI81	GSAQADVPKELEREEsGAAEsPALVtPDSEKSAKHGsGAFy
Q96EK9	T189	Sugiyama	KTI12 SBBI81	DVPKELEREEsGAAEsPALVtPDSEKSAKHGsGAFysPELL
Q96F46	T780	SIGNOR\|EPSD\|PSP	IL17RA IL17R	LSCQAQGGCSRPAMVLTDPHtPYEEEQRQSVQsDQGyIsRs
Q96G01	S585	SIGNOR\|iPTMNet\|EPSD	BICD1	RRGVssPVETRTSSEPVAKEsTEASKEPsPtKtPtIsPVIT
Q96G01	T597	SIGNOR\|iPTMNet\|EPSD	BICD1	SSEPVAKEsTEASKEPsPtKtPtIsPVITAPPssPVLDtsD
Q96IG2	S139	PSP	FBXL20 FBL2	IEVLNLNGCTKTTDATCTSLsKFCsKLRHLDLASCTSITNM
Q96IG2	S143	PSP	FBXL20 FBL2	NLNGCTKTTDATCTSLsKFCsKLRHLDLASCTSITNMSLKA
Q96IG2	S251	PSP	FBXL20 FBL2	CLQITDEGLITICRGCHKLQsLCAsGCSNITDAILNALGQN
Q96IG2	S255	PSP	FBXL20 FBL2	TDEGLITICRGCHKLQsLCAsGCSNITDAILNALGQNCPRL
Q96IG2	S421	PSP	FBXL20 FBL2	RTHLPNIKVHAyFAPVtPPPsVGGsRQRFCRCCIIL_____
Q96IG2	S425	PSP	FBXL20 FBL2	PNIKVHAyFAPVtPPPsVGGsRQRFCRCCIIL_________
Q96IG2	T417	PSP	FBXL20 FBL2	IKRLRTHLPNIKVHAyFAPVtPPPsVGGsRQRFCRCCIIL_
Q96K76	S910	Sugiyama	USP47	DGDNGDssKstEtsDFENIEsPLNERDsSAsVDNRELEQHI
Q96KS0	S401	EPSD\|PSP	EGLN2 EIT6	AAAKDKYQLASGQKGVQVPVsQPPtPT______________
Q96KS0	T405	EPSD\|PSP	EGLN2 EIT6	DKYQLASGQKGVQVPVsQPPtPT__________________
Q96R06	S974	SIGNOR\|EPSD\|PSP	SPAG5	sMVSLQPAETPGMEESLAEMsIMTtELQSLCSLLQESKEEA
Q96R06	T111	SIGNOR\|EPSD\|PSP	SPAG5	ETCQHEsDEQPLDPIPQIsstPKTsEEAVDPLGNyMVKtIV
Q96R06	T937	SIGNOR\|EPSD\|PSP	SPAG5	NDRTFLGSILTAVADEEPEStPVPLLGsDKSAFTRVAsMVS
Q96R06	T978	SIGNOR\|EPSD\|PSP	SPAG5	LQPAETPGMEESLAEMsIMTtELQSLCSLLQESKEEAIRTL
Q96RR4	S129	SIGNOR	CAMKK2 CAMKKB KIAA0787	LAAGGsLDMNGRCICPsLPysPVssPQssPRLPRRPTVESH
Q96RR4	S133	SIGNOR	CAMKK2 CAMKKB KIAA0787	GsLDMNGRCICPsLPysPVssPQssPRLPRRPTVESHHVSI
Q96RR4	S137	SIGNOR	CAMKK2 CAMKKB KIAA0787	MNGRCICPsLPysPVssPQssPRLPRRPTVESHHVSITGMQ
Q99250	T1966	SIGNOR	SCN2A HBA NAC2 SCN2A1 SCN2A2	KEDTLIDKLNENSTPEKTDMtPstTSPPSYDSVTKPEKEKF
Q99459	T385	Sugiyama	CDC5L KIAA0432 PCDC5RP	EAQNLMALtNVDtPLKGGLNtPLHEsDFsGVtPQRQVVQtP
Q99626	S283	SIGNOR\|EPSD\|PSP	CDX2 CDX3	PPPQPPQPQPGPLRSVPEPLsPVSsLQAsVPGsVPGVLGPT
Q99626	S287	SIGNOR\|EPSD	CDX2 CDX3	PPQPQPGPLRSVPEPLsPVSsLQAsVPGsVPGVLGPTGGVL
Q99626	S291	SIGNOR\|EPSD	CDX2 CDX3	QPGPLRSVPEPLsPVSsLQAsVPGsVPGVLGPTGGVLNPTV
Q99626	S295	SIGNOR\|EPSD	CDX2 CDX3	LRSVPEPLsPVSsLQAsVPGsVPGVLGPTGGVLNPTVTQ__
Q99684	S94	SIGNOR\|PSP	GFI1 ZNF163	sCEGSVCERSSEFEDFWRPPsPsAsPAsEKSMCPSLDEAQP
Q99684	S98	SIGNOR\|PSP	GFI1 ZNF163	SVCERSSEFEDFWRPPsPsAsPAsEKSMCPSLDEAQPFPLP
Q9BPU6	T516	SIGNOR\|PSP	DPYSL5 CRMP5 ULIP6	VAVVVHPGKKEMGtPLADtPtRPVTRHGGMRDLHEssFsLS
Q9BQE3	S439	Sugiyama	TUBA1C TUBA6	SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	T82	Sugiyama	TUBA1C TUBA6	VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q9BVA1	S75	Sugiyama	TUBB2B	tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BXF6	S188	PSP	RAB11FIP5 GAF1 KIAA0857 RIP11	FTRNNLsAsMFDLSMKDKPRsPFSKIRDKMKGKKKyDLEsA
Q9BXF6	T276	PSP	RAB11FIP5 GAF1 KIAA0857 RIP11	stLSSASGSLAYQGPGAELLtRsPsRssWLsTEGGRDsAQs
Q9BYG3	S230	GPS6\|ELM\|EPSD\|PSP	NIFK MKI67IP NOPP34	LRKKKKKVsGtLDtPEKtVDsQGPtPVCtPtFLERRKsQVA
Q9BYG3	T234	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	NIFK MKI67IP NOPP34	KKKVsGtLDtPEKtVDsQGPtPVCtPtFLERRKsQVAELND
Q9BYX7	S239	Sugiyama	POTEKP ACTBL3 FKSG30	VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7	Y362	Sugiyama	POTEKP ACTBL3 FKSG30	GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q9BZS1	S270	SIGNOR\|EPSD\|PSP	FOXP3 IPEX JM2	KEKLSAMQAHLAGKMALTKAsSVAsSDKGSCCIVAAGSQGP
Q9BZS1	S274	SIGNOR\|EPSD\|PSP	FOXP3 IPEX JM2	SAMQAHLAGKMALTKAsSVAsSDKGSCCIVAAGSQGPVVPA
Q9GZV5	S58	SIGNOR	WWTR1 TAZ	PKPSSWRKKILPESFFKEPDsGsHsRQsstDSsGGHPGPRL
Q9GZV5	S62	SIGNOR	WWTR1 TAZ	SWRKKILPESFFKEPDsGsHsRQsstDSsGGHPGPRLAGGA
Q9H0B6	S608	EPSD\|PSP	KLC2	KsVEEPTQPGGTGLsDsRtLssssMDLsRRssLVG______
Q9H0Z9	S195	SIGNOR\|EPSD\|PSP	RBM38 RNPC1 SEB4	ASPAYAQYPPATYDQYPYAAsPATAASFVGYSYPAAVPQAL
Q9H6T3	T491	Sugiyama	RPAP3	ATGTTSKKNssQDDLFPTsDtPRAKVLKIEEVsDTssLQPQ
Q9NP62	S322	EPSD\|PSP	GCM1 GCMA	ALGRNHLADNCYSNYPFPLTsWPCsFSPSQNSSEPFYQQLP
Q9NQX3	S270	SIGNOR	GPHN GPH KIAA1385	SRGVQVLPRDTAsLsttPsEsPRAQAtsRLstAsCPtPKVQ
Q9NRD5	S342	EPSD\|PSP	PICK1 PRKCABP	LDQKHVQDIVFQLQRLVsTMsKYYNDCYAVLRDADVFPIEV
Q9NRD5	S415	EPSD\|PSP	PICK1 PRKCABP	PSRDTRGAAGPLDKGGsWCDs____________________
Q9NRR4	S300	SIGNOR\|EPSD\|PSP	DROSHA RN3 RNASE3L RNASEN	SYERSRERERERHRHRDNRRsPsLERSYKKEYKRSGRSYGL
Q9NRR4	S302	SIGNOR\|EPSD\|PSP	DROSHA RN3 RNASE3L RNASEN	ERSRERERERHRHRDNRRsPsLERSYKKEYKRSGRSYGLSV
Q9NW38	T178	PSP	FANCL PHF9	YPAESPDYFVDFPVPFCASWtPQSSLISIYSQFLAAIESLK
Q9NXG6	S485	Sugiyama	P4HTM PH4	ARQALFQQEMARLAREGGtDsQPEWALDRAYRDARVEL___
Q9NYF8	S531	EPSD\|PSP	BCLAF1 BTF KIAA0164	ysPPLHKNLDAREKstFREEsPLRIKMIAsDSHRPEVKLKM
Q9NZ72	S60	SIGNOR\|PSP	STMN3 SCLIP	MEVKQLDKRAsGQsFEVILKsPSDLsPEsPMLssPPKKKDt
Q9NZN8	S242	Sugiyama	CNOT2 CDC36 NOT2 HSPC131 MSTP046	VTGLDLSDFPALADRNRREGsGNPtPLINPLAGRAPYVGMV
Q9NZN8	T246	Sugiyama	CNOT2 CDC36 NOT2 HSPC131 MSTP046	DLSDFPALADRNRREGsGNPtPLINPLAGRAPYVGMVTKPA
Q9NZQ7	S184	SIGNOR\|PSP	CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1	EVIWTSSDHQVLSGKTtTTNsKREEKLFNVtsTLRINTTTN
Q9NZQ7	T180	SIGNOR\|PSP	CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1	YPKAEVIWTSSDHQVLSGKTtTTNsKREEKLFNVtsTLRIN
Q9P0L2	S219	GPS6\|EPSD	MARK1 KIAA1477 MARK	ADFGFSNEFTVGNKLDtFCGsPPYAAPELFQGKKYDGPEVD
Q9UHD2	S172	PSP	TBK1 NAK	VyKLtDFGAARELEDDEQFVsLyGtEEyLHPDMYERAVLRK
Q9UKA4	T1136	SIGNOR\|EPSD\|PSP	AKAP11 AKAP220 KIAA0629	DIKKLTKKLKGELAKEFAPAtPPstPHNSSVGSLSENEQNT
Q9UKA4	T1140	EPSD\|PSP	AKAP11 AKAP220 KIAA0629	LTKKLKGELAKEFAPAtPPstPHNSSVGSLSENEQNTIEKE
Q9UKC9	T404	PSP	FBXL2 FBL2 FBL3	IKRMRAQLPHVKVHAYFAPVtPPTAVAGSGQRLCRCCVIL_
Q9UKT5	S12	SIGNOR\|EPSD\|PSP	FBXO4 FBX4	_________MAGSEPRsGtNsPPPPFSDWGRLEAAILSGWK
Q9UKT6	T33	SIGNOR\|PSP	FBXL21P FBL21 FBL3 FBXL21 FBXL3B FBXL3P	VQLSGAAKQPKVGFYSSLNQtHTHTVLLDWGSLPHHVVLQI
Q9UKT9	S378	PSP	IKZF3 ZNFN1A3	ELEKKSIHLPEKSVPSERGLsPNNsGHDstDtDsNHEERQN
Q9UMX1	S342	GPS6\|EPSD\|PSP	SUFU UNQ650/PRO1280	PVLPPINPQRQNGLAHDRAPsRKDsLEsDsstAIIPHELIR
Q9UNE7	S19	Sugiyama	STUB1 CHIP PP1131	__MKGKEEKEGGARLGAGGGsPEKsPsAQELKEQGNRLFVG
Q9UNE7	S23	Sugiyama	STUB1 CHIP PP1131	GKEEKEGGARLGAGGGsPEKsPsAQELKEQGNRLFVGRKYP
Q9UPN3	S7222	SIGNOR\|PSP	MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251	FILPEGASQGMtPFRSRGRRsKPSsRAAsPtRssssASQSN
Q9UPN3	S7226	PSP	MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251	EGASQGMtPFRSRGRRsKPSsRAAsPtRssssASQSNHsCT
Q9UPN3	S7230	SIGNOR\|PSP	MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251	QGMtPFRSRGRRsKPSsRAAsPtRssssASQSNHsCTSMPs
Q9UPN3	S7234	SIGNOR\|PSP	MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251	PFRSRGRRsKPSsRAAsPtRssssASQSNHsCTSMPssPAT
Q9UPN3	S7310	SIGNOR\|PSP	MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251	sssPAsTGAKTNRADPKKSAsRPGsRAGsRAGsRASsRRGs
Q9UPN3	S7314	SIGNOR\|PSP	MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251	AsTGAKTNRADPKKSAsRPGsRAGsRAGsRASsRRGsDAsD
Q9UPN3	S7318	SIGNOR\|PSP	MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251	AKTNRADPKKSAsRPGsRAGsRAGsRASsRRGsDAsDFDLL
Q9UPN3	S7322	SIGNOR\|PSP	MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251	RADPKKSAsRPGsRAGsRAGsRASsRRGsDAsDFDLLEtQs
Q9UPN3	S7326	SIGNOR\|PSP	MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251	KKSAsRPGsRAGsRAGsRASsRRGsDAsDFDLLEtQsACsD
Q9UPN3	S7330	SIGNOR\|PSP	MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251	sRPGsRAGsRAGsRASsRRGsDAsDFDLLEtQsACsDTSES
Q9UQD0	T1938	SIGNOR	SCN8A MED	KKTTSNKLENGGTHREKKEStPSTASLPSYDSVTKPEKEKQ
Q9Y266	S139	Sugiyama	NUDC	IDQKKDAENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKL
Q9Y266	T145	Sugiyama	NUDC	AENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKLKPNLGN
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2X9	S638	SIGNOR\|EPSD\|PSP	ZNF281 GZP1 ZBP99	SEsQKEDPFNIAEPRVDLHtsGEHsELVQEENLsPGtQtPS
Q9Y448	T294	PSP	KNSTRN C15orf23 SKAP TRAF4AF1 HSD11	QALKVKLEMKEERVRFLEQQtLCNNQVNDLTTALKEMEQLL
Q9Y4K3	T266	SIGNOR\|PSP	TRAF6 RNF85	TFGCHEKMQRNHLARHLQENtQSHMRMLAQAVHSLSVIPDS
Q9Y696	S226	Sugiyama	CLIC4	RNFDIPKEMTGIWRYLtNAysRDEFtNtCPsDKEVEIAysD
Q9Y6H5	S556	SIGNOR\|EPSD\|PSP	SNCAIP	RVTLQNQLQQFLEAQKSEGKsLPSSPSSPSSPASRKSQWKS
Q9Y6K9	S17	EPSD\|PSP	IKBKG FIP3 NEMO	____MNRHLWKsQLCEMVQPsGGPAADQDVLGEEsPLGKPA
Q9Y6K9	S31	EPSD\|PSP	IKBKG FIP3 NEMO	CEMVQPsGGPAADQDVLGEEsPLGKPAMLHLPsEQGAPETL
Q9Y6K9	S43	EPSD\|PSP	IKBKG FIP3 NEMO	DQDVLGEEsPLGKPAMLHLPsEQGAPETLQRCLEENQELRD
Q9Y6K9	S8	EPSD\|PSP	IKBKG FIP3 NEMO	_____________MNRHLWKsQLCEMVQPsGGPAADQDVLG

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cell Cycle	R-HSA-1640170	1.391554e-12	11.857	1	0
Cell Cycle, Mitotic	R-HSA-69278	3.085643e-12	11.511	1	0
Chromatin organization	R-HSA-4839726	5.950218e-11	10.225	0	0
Chromatin modifying enzymes	R-HSA-3247509	4.018607e-09	8.396	0	0
M Phase	R-HSA-68886	5.938140e-09	8.226	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.694464e-09	8.174	1	0
Mitotic Prometaphase	R-HSA-68877	7.747662e-09	8.111	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.288678e-08	7.640	0	0
Signal Transduction	R-HSA-162582	2.231978e-08	7.651	1	0
Separation of Sister Chromatids	R-HSA-2467813	4.435282e-08	7.353	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	1.459370e-07	6.836	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.602600e-07	6.795	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.560128e-07	6.592	0	0
Mitotic Anaphase	R-HSA-68882	3.064662e-07	6.514	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.519564e-07	6.454	0	0
Cell Cycle Checkpoints	R-HSA-69620	1.004896e-06	5.998	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.513521e-06	5.820	0	0
Amplification of signal from the kinetochores	R-HSA-141424	1.513521e-06	5.820	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.969172e-06	5.706	0	0
Mitotic G2-G2/M phases	R-HSA-453274	2.106802e-06	5.676	0	0
G2/M Transition	R-HSA-69275	6.877691e-06	5.163	0	0
Apoptotic execution phase	R-HSA-75153	1.362229e-05	4.866	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	1.409762e-05	4.851	1	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.576032e-05	4.802	0	0
MITF-M-dependent gene expression	R-HSA-9856651	1.608281e-05	4.794	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.838253e-05	4.736	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	2.352217e-05	4.629	0	0
Cellular Senescence	R-HSA-2559583	2.608001e-05	4.584	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	5.267261e-05	4.278	0	0
Recycling pathway of L1	R-HSA-437239	5.381793e-05	4.269	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	5.584197e-05	4.253	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	7.735728e-05	4.111	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	7.735728e-05	4.111	0	0
Membrane Trafficking	R-HSA-199991	9.558439e-05	4.020	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.061667e-04	3.974	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.114515e-04	3.953	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.125658e-04	3.949	0	0
Formation of definitive endoderm	R-HSA-9823730	1.410704e-04	3.851	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.578594e-04	3.802	0	0
AURKA Activation by TPX2	R-HSA-8854518	1.568553e-04	3.805	0	0
Deubiquitination	R-HSA-5688426	1.792863e-04	3.746	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.242862e-04	3.649	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.242862e-04	3.649	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.452171e-04	3.610	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.908799e-04	3.536	0	0
Signaling by ALK in cancer	R-HSA-9700206	2.908799e-04	3.536	0	0
L1CAM interactions	R-HSA-373760	2.972347e-04	3.527	0	0
Oncogenic MAPK signaling	R-HSA-6802957	3.092460e-04	3.510	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.186486e-04	3.497	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	3.209062e-04	3.494	0	0
Axon guidance	R-HSA-422475	3.292125e-04	3.483	1	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.487247e-04	3.458	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.604089e-04	3.443	0	0
Nervous system development	R-HSA-9675108	4.236409e-04	3.373	1	0
Transcriptional Regulation by TP53	R-HSA-3700989	4.253028e-04	3.371	0	0
Regulation of TP53 Activity	R-HSA-5633007	4.289679e-04	3.368	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.604852e-04	3.337	0	0
Post NMDA receptor activation events	R-HSA-438064	4.915962e-04	3.308	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	5.235188e-04	3.281	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	5.386560e-04	3.269	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.773011e-04	3.239	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	7.525876e-04	3.123	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	7.525876e-04	3.123	0	0
PKMTs methylate histone lysines	R-HSA-3214841	7.185896e-04	3.144	0	0
Signaling by Hippo	R-HSA-2028269	7.426247e-04	3.129	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	7.754771e-04	3.110	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	7.831200e-04	3.106	0	0
Kinesins	R-HSA-983189	7.921252e-04	3.101	0	0
HDMs demethylate histones	R-HSA-3214842	9.290006e-04	3.032	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	9.708287e-04	3.013	0	0
Cell-extracellular matrix interactions	R-HSA-446353	1.012364e-03	2.995	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.033333e-03	2.986	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.083206e-03	2.965	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.229200e-03	2.910	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.229200e-03	2.910	0	0
Estrogen-dependent gene expression	R-HSA-9018519	1.206514e-03	2.918	0	0
Nuclear import of Rev protein	R-HSA-180746	1.199843e-03	2.921	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.236649e-03	2.908	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.281209e-03	2.892	0	0
Intracellular signaling by second messengers	R-HSA-9006925	1.287567e-03	2.890	1	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.377012e-03	2.861	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.377012e-03	2.861	0	0
S Phase	R-HSA-69242	1.390367e-03	2.857	1	0
Death Receptor Signaling	R-HSA-73887	1.408047e-03	2.851	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	1.573413e-03	2.803	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.615122e-03	2.792	0	0
Centrosome maturation	R-HSA-380287	1.655581e-03	2.781	0	0
ISG15 antiviral mechanism	R-HSA-1169408	1.655581e-03	2.781	0	0
Mitotic Prophase	R-HSA-68875	1.874357e-03	2.727	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	1.919377e-03	2.717	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.969933e-03	2.706	0	0
Regulation of TP53 Expression	R-HSA-6804754	1.984055e-03	2.702	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	2.177446e-03	2.662	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.177446e-03	2.662	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	2.164646e-03	2.665	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.272959e-03	2.643	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.272959e-03	2.643	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.326002e-03	2.633	0	0
PIP3 activates AKT signaling	R-HSA-1257604	2.591266e-03	2.586	1	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.679312e-03	2.572	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.680793e-03	2.572	0	0
Cell-Cell communication	R-HSA-1500931	2.919029e-03	2.535	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.771377e-03	2.557	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.960375e-03	2.529	0	0
Apoptosis	R-HSA-109581	2.996323e-03	2.523	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.201156e-03	2.495	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.255113e-03	2.487	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	3.356192e-03	2.474	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.463502e-03	2.460	0	0
Polo-like kinase mediated events	R-HSA-156711	3.600169e-03	2.444	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.754708e-03	2.425	0	0
Developmental Biology	R-HSA-1266738	3.789830e-03	2.421	1	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	3.839366e-03	2.416	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	3.887235e-03	2.410	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	4.038084e-03	2.394	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	4.226665e-03	2.374	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	4.226665e-03	2.374	0	0
G0 and Early G1	R-HSA-1538133	4.772645e-03	2.321	0	0
COPI-mediated anterograde transport	R-HSA-6807878	4.294091e-03	2.367	0	0
Epigenetic regulation of gene expression	R-HSA-212165	4.530234e-03	2.344	1	0
Cell junction organization	R-HSA-446728	4.588829e-03	2.338	0	0
MAP kinase activation	R-HSA-450294	4.855116e-03	2.314	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.420682e-03	2.355	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.828396e-03	2.316	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.733754e-03	2.325	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	4.968801e-03	2.304	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	4.968801e-03	2.304	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	5.119904e-03	2.291	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.179690e-03	2.286	0	0
PTEN Regulation	R-HSA-6807070	5.222667e-03	2.282	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	5.243186e-03	2.280	0	0
Repression of WNT target genes	R-HSA-4641265	5.432566e-03	2.265	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	5.654864e-03	2.248	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	5.812065e-03	2.236	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	5.827377e-03	2.235	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	6.850975e-03	2.164	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	6.850975e-03	2.164	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	7.241775e-03	2.140	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.850975e-03	2.164	0	0
MTOR signalling	R-HSA-165159	6.782754e-03	2.169	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	6.955871e-03	2.158	0	0
CREB phosphorylation	R-HSA-199920	6.860140e-03	2.164	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	7.023258e-03	2.153	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	5.990831e-03	2.223	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	7.446268e-03	2.128	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	7.446268e-03	2.128	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	7.548716e-03	2.122	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	8.096306e-03	2.092	0	0
Ub-specific processing proteases	R-HSA-5689880	8.128961e-03	2.090	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	8.856986e-03	2.053	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	8.900547e-03	2.051	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	8.900547e-03	2.051	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.139256e-03	2.039	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	9.741940e-03	2.011	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.003054e-02	1.999	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.084431e-02	1.965	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	1.106652e-02	1.956	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.106652e-02	1.956	0	0
HATs acetylate histones	R-HSA-3214847	1.100842e-02	1.958	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.164490e-02	1.934	0	0
Switching of origins to a post-replicative state	R-HSA-69052	1.119197e-02	1.951	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	1.137628e-02	1.944	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.119197e-02	1.951	0	0
NRAGE signals death through JNK	R-HSA-193648	1.100893e-02	1.958	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.140276e-02	1.943	0	0
Cellular response to heat stress	R-HSA-3371556	1.200339e-02	1.921	1	0
mTORC1-mediated signalling	R-HSA-166208	1.208988e-02	1.918	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.216776e-02	1.915	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	1.231400e-02	1.910	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	1.255463e-02	1.901	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.255463e-02	1.901	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.255463e-02	1.901	0	0
Signaling by RAS mutants	R-HSA-6802949	1.255463e-02	1.901	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.255463e-02	1.901	0	0
Gastrulation	R-HSA-9758941	1.315997e-02	1.881	0	0
Signaling by RAF1 mutants	R-HSA-9656223	1.329379e-02	1.876	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.375206e-02	1.862	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.396277e-02	1.855	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.427843e-02	1.845	0	0
Rap1 signalling	R-HSA-392517	1.432573e-02	1.844	0	0
Nuclear RNA decay	R-HSA-9930044	1.450462e-02	1.838	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.576786e-02	1.802	0	0
Formation of annular gap junctions	R-HSA-196025	1.519665e-02	1.818	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.541699e-02	1.812	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.659600e-02	1.780	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	1.471047e-02	1.832	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.471529e-02	1.832	0	0
Interleukin-17 signaling	R-HSA-448424	1.536250e-02	1.814	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.619331e-02	1.791	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	1.519665e-02	1.818	0	0
Cellular responses to stress	R-HSA-2262752	1.466733e-02	1.834	1	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.483557e-02	1.829	1	1
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.677372e-02	1.775	0	0
Phosphorylation of the APC/C	R-HSA-176412	1.677372e-02	1.775	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.689786e-02	1.772	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.711634e-02	1.767	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.719324e-02	1.765	1	1
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.772425e-02	1.751	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.772425e-02	1.751	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.778610e-02	1.750	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.778610e-02	1.750	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.778610e-02	1.750	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.779530e-02	1.750	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.779530e-02	1.750	0	0
Negative regulation of MET activity	R-HSA-6807004	1.779530e-02	1.750	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.923281e-02	1.716	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.923281e-02	1.716	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.801493e-02	1.744	0	0
Deadenylation of mRNA	R-HSA-429947	1.801493e-02	1.744	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.896312e-02	1.722	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.880077e-02	1.726	0	0
Adherens junctions interactions	R-HSA-418990	2.099325e-02	1.678	0	0
G alpha (12/13) signalling events	R-HSA-416482	1.944419e-02	1.711	0	0
Gene expression (Transcription)	R-HSA-74160	1.825705e-02	1.739	1	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.896312e-02	1.722	0	0
Signaling by ALK	R-HSA-201556	1.896312e-02	1.722	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.986064e-02	1.702	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	2.100666e-02	1.678	0	0
Gap junction degradation	R-HSA-190873	2.117334e-02	1.674	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	2.117334e-02	1.674	0	0
ALK mutants bind TKIs	R-HSA-9700645	2.117334e-02	1.674	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.117334e-02	1.674	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	2.123222e-02	1.673	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	2.162650e-02	1.665	0	0
Sema4D in semaphorin signaling	R-HSA-400685	2.166277e-02	1.664	0	0
TGFBR3 expression	R-HSA-9839394	2.166277e-02	1.664	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.182940e-02	1.661	0	0
Signaling by EGFR	R-HSA-177929	2.241644e-02	1.649	0	0
tRNA processing in the nucleus	R-HSA-6784531	2.303509e-02	1.638	0	0
EGFR downregulation	R-HSA-182971	2.471059e-02	1.607	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.489375e-02	1.604	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.489375e-02	1.604	0	0
Regulation of CDH1 Function	R-HSA-9764561	2.521202e-02	1.598	0	0
Cellular responses to stimuli	R-HSA-8953897	2.528192e-02	1.597	1	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	2.541898e-02	1.595	1	1
Semaphorin interactions	R-HSA-373755	2.575134e-02	1.589	1	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.619145e-02	1.582	0	0
Specification of primordial germ cells	R-HSA-9827857	2.634874e-02	1.579	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.646965e-02	1.577	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.825721e-02	1.549	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.825721e-02	1.549	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	2.825721e-02	1.549	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.825721e-02	1.549	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.825721e-02	1.549	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.803274e-02	1.552	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.079589e-02	1.512	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.156893e-02	1.501	0	0
Notch-HLH transcription pathway	R-HSA-350054	3.175417e-02	1.498	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.049447e-02	1.516	0	0
MAP2K and MAPK activation	R-HSA-5674135	2.881580e-02	1.540	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.200562e-02	1.495	0	0
Regulation of mitotic cell cycle	R-HSA-453276	3.200562e-02	1.495	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.893373e-02	1.539	1	1
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.079589e-02	1.512	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	2.720311e-02	1.565	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.950550e-02	1.530	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.124842e-02	1.505	0	0
ESR-mediated signaling	R-HSA-8939211	2.919757e-02	1.535	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.049447e-02	1.516	0	0
MAPK family signaling cascades	R-HSA-5683057	3.207817e-02	1.494	0	0
Programmed Cell Death	R-HSA-5357801	3.115846e-02	1.506	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.226275e-02	1.491	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.230608e-02	1.491	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.230608e-02	1.491	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	3.311786e-02	1.480	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	3.348526e-02	1.475	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	3.348526e-02	1.475	0	0
Cardiogenesis	R-HSA-9733709	3.348526e-02	1.475	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.348526e-02	1.475	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.373407e-02	1.472	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.396051e-02	1.469	0	0
G2/M Checkpoints	R-HSA-69481	3.446620e-02	1.463	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.479367e-02	1.458	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.515766e-02	1.454	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.515766e-02	1.454	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.531168e-02	1.452	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.700750e-02	1.432	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.726261e-02	1.429	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.771697e-02	1.423	0	0
Gap junction trafficking and regulation	R-HSA-157858	3.816547e-02	1.418	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	3.903057e-02	1.409	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.910131e-02	1.408	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	3.931259e-02	1.405	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.021633e-02	1.396	0	0
Synthesis of DNA	R-HSA-69239	4.127423e-02	1.384	0	0
Gap junction trafficking	R-HSA-190828	4.192439e-02	1.378	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	4.214142e-02	1.375	0	0
Regulation of endogenous retroelements	R-HSA-9842860	4.231279e-02	1.374	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	4.252479e-02	1.371	0	0
Macroautophagy	R-HSA-1632852	4.262350e-02	1.370	0	0
TNF signaling	R-HSA-75893	4.312258e-02	1.365	0	0
Heme signaling	R-HSA-9707616	4.320006e-02	1.365	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.412370e-02	1.355	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.412370e-02	1.355	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.412370e-02	1.355	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.412370e-02	1.355	0	0
RAF activation	R-HSA-5673000	4.423484e-02	1.354	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	4.423484e-02	1.354	0	0
Neurodegenerative Diseases	R-HSA-8863678	4.438733e-02	1.353	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	4.438733e-02	1.353	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	4.518822e-02	1.345	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	4.600449e-02	1.337	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	4.600449e-02	1.337	0	0
Aggrephagy	R-HSA-9646399	4.600449e-02	1.337	0	0
Type I hemidesmosome assembly	R-HSA-446107	5.643770e-02	1.248	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	5.643770e-02	1.248	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	5.643770e-02	1.248	0	0
Signaling by AMER1 mutants	R-HSA-4839748	4.750595e-02	1.323	1	0
Signaling by GSK3beta mutants	R-HSA-5339716	4.750595e-02	1.323	1	1
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.815412e-02	1.235	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	5.824019e-02	1.235	0	0
Metabolism of non-coding RNA	R-HSA-194441	5.826285e-02	1.235	0	0
snRNP Assembly	R-HSA-191859	5.826285e-02	1.235	0	0
G1/S Transition	R-HSA-69206	4.694526e-02	1.328	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	5.533348e-02	1.257	0	0
Oncogene Induced Senescence	R-HSA-2559585	5.039917e-02	1.298	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.680068e-02	1.330	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	5.268055e-02	1.278	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	4.816545e-02	1.317	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	4.782134e-02	1.320	0	0
Disorders of Developmental Biology	R-HSA-9675151	5.815412e-02	1.235	0	0
HIV Life Cycle	R-HSA-162587	5.412558e-02	1.267	0	0
Selective autophagy	R-HSA-9663891	5.325407e-02	1.274	0	0
Vesicle-mediated transport	R-HSA-5653656	5.700697e-02	1.244	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.188039e-02	1.285	0	0
Chaperonin-mediated protein folding	R-HSA-390466	4.910337e-02	1.309	0	0
RET signaling	R-HSA-8853659	5.711088e-02	1.243	0	0
Interleukin-37 signaling	R-HSA-9008059	4.800728e-02	1.319	0	0
Breakdown of the nuclear lamina	R-HSA-352238	5.846371e-02	1.233	0	0
Glycolysis	R-HSA-70171	5.877168e-02	1.231	0	0
Cell-cell junction organization	R-HSA-421270	5.877364e-02	1.231	0	0
MHC class II antigen presentation	R-HSA-2132295	5.924247e-02	1.227	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	5.925767e-02	1.227	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	5.925767e-02	1.227	1	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	5.925767e-02	1.227	1	1
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	5.925767e-02	1.227	1	1
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	5.925767e-02	1.227	1	1
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	5.925767e-02	1.227	1	1
Rab regulation of trafficking	R-HSA-9007101	6.130451e-02	1.213	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	6.306288e-02	1.200	0	0
Host Interactions of HIV factors	R-HSA-162909	6.319456e-02	1.199	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	6.386760e-02	1.195	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	6.386760e-02	1.195	0	0
IRS activation	R-HSA-74713	6.386760e-02	1.195	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	6.386760e-02	1.195	0	0
Signaling by ERBB2	R-HSA-1227986	6.402236e-02	1.194	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	6.476573e-02	1.189	0	0
Signaling by PDGFR in disease	R-HSA-9671555	6.481344e-02	1.188	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	6.509450e-02	1.186	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	6.548122e-02	1.184	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.980495e-02	1.156	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.980495e-02	1.156	0	0
PKR-mediated signaling	R-HSA-9833482	7.115436e-02	1.148	0	0
Signaling by MET	R-HSA-6806834	7.115436e-02	1.148	0	0
HDACs deacetylate histones	R-HSA-3214815	7.126953e-02	1.147	0	0
Signaling by VEGF	R-HSA-194138	7.164583e-02	1.145	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	7.249725e-02	1.140	0	0
Calcineurin activates NFAT	R-HSA-2025928	7.249725e-02	1.140	0	0
Unwinding of DNA	R-HSA-176974	7.249725e-02	1.140	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	7.251709e-02	1.140	0	0
Formation of axial mesoderm	R-HSA-9796292	7.251709e-02	1.140	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	7.251709e-02	1.140	0	0
G2/M DNA damage checkpoint	R-HSA-69473	7.308430e-02	1.136	0	0
Adipogenesis	R-HSA-9843745	7.332654e-02	1.135	0	0
Autophagy	R-HSA-9612973	7.455676e-02	1.128	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	7.493196e-02	1.125	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	9.566661e-02	1.019	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	9.566661e-02	1.019	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	9.566661e-02	1.019	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	9.566661e-02	1.019	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	9.566661e-02	1.019	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	9.566661e-02	1.019	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	9.566661e-02	1.019	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	9.566661e-02	1.019	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	9.566661e-02	1.019	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	9.566661e-02	1.019	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	9.566661e-02	1.019	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	8.696333e-02	1.061	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	8.696333e-02	1.061	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	8.696333e-02	1.061	0	0
Phosphorylation of Emi1	R-HSA-176417	8.696333e-02	1.061	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	9.061798e-02	1.043	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.725923e-02	1.059	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.725923e-02	1.059	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	9.498886e-02	1.022	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.002243e-01	0.999	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.002243e-01	0.999	0	0
Activation of the pre-replicative complex	R-HSA-68962	1.002243e-01	0.999	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.002243e-01	0.999	0	0
Nucleosome assembly	R-HSA-774815	8.869562e-02	1.052	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	8.869562e-02	1.052	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.758692e-02	1.011	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.818443e-02	1.107	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.665230e-02	1.115	0	0
mRNA 3'-end processing	R-HSA-72187	9.555954e-02	1.020	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.555954e-02	1.020	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.234402e-02	1.035	0	0
Nucleotide Excision Repair	R-HSA-5696398	8.858158e-02	1.053	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	9.498886e-02	1.022	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	8.822313e-02	1.054	0	0
Regulation of CDH11 function	R-HSA-9762292	9.061798e-02	1.043	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.402332e-02	1.076	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.402332e-02	1.076	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	9.539553e-02	1.020	1	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	8.353245e-02	1.078	0	0
Signaling by PTK6	R-HSA-8848021	8.353245e-02	1.078	0	0
HIV Infection	R-HSA-162906	9.333924e-02	1.030	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	8.696333e-02	1.061	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	8.696333e-02	1.061	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	9.878368e-02	1.005	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	8.900064e-02	1.051	0	0
Protein folding	R-HSA-391251	7.772193e-02	1.109	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	8.157429e-02	1.088	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.918076e-02	1.101	0	0
Regulation of gene expression in beta cells	R-HSA-210745	8.900064e-02	1.051	0	0
Signaling by NOTCH1	R-HSA-1980143	8.559983e-02	1.068	0	0
Signaling by NTRKs	R-HSA-166520	9.985031e-02	1.001	0	0
Regulation of beta-cell development	R-HSA-186712	1.014285e-01	0.994	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.029208e-01	0.987	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	1.034370e-01	0.985	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	1.034370e-01	0.985	1	1
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.034370e-01	0.985	0	0
DCC mediated attractive signaling	R-HSA-418885	1.034370e-01	0.985	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.034370e-01	0.985	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.040478e-01	0.983	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.043082e-01	0.982	0	0
PI Metabolism	R-HSA-1483255	1.044608e-01	0.981	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.069899e-01	0.971	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	1.085875e-01	0.964	1	0
Cilium Assembly	R-HSA-5617833	1.090181e-01	0.963	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	1.093459e-01	0.961	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.093459e-01	0.961	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.095067e-01	0.961	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.095067e-01	0.961	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.095067e-01	0.961	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.095067e-01	0.961	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.100126e-01	0.959	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.100126e-01	0.959	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.100126e-01	0.959	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.100126e-01	0.959	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.100126e-01	0.959	0	0
Signaling by APC mutants	R-HSA-4839744	1.106748e-01	0.956	1	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.106748e-01	0.956	1	1
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.106748e-01	0.956	1	1
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.106748e-01	0.956	1	1
ChREBP activates metabolic gene expression	R-HSA-163765	1.106748e-01	0.956	0	0
G1/S-Specific Transcription	R-HSA-69205	1.111836e-01	0.954	0	0
Regulation of TP53 Degradation	R-HSA-6804757	1.111836e-01	0.954	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	1.130292e-01	0.947	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	1.130292e-01	0.947	0	0
DNA Repair	R-HSA-73894	1.172566e-01	0.931	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.190119e-01	0.924	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.190252e-01	0.924	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	1.209837e-01	0.917	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	1.209837e-01	0.917	0	0
Drug resistance of KIT mutants	R-HSA-9669937	1.214505e-01	0.916	0	0
Drug resistance of PDGFR mutants	R-HSA-9674415	1.214505e-01	0.916	0	0
KIT mutants bind TKIs	R-HSA-9669921	1.214505e-01	0.916	0	0
PDGFR mutants bind TKIs	R-HSA-9674428	1.214505e-01	0.916	0	0
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.214505e-01	0.916	0	0
Masitinib-resistant KIT mutants	R-HSA-9669924	1.214505e-01	0.916	0	0
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.214505e-01	0.916	0	0
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.214505e-01	0.916	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.214505e-01	0.916	0	0
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.214505e-01	0.916	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.214505e-01	0.916	0	0
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.214505e-01	0.916	0	0
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.214505e-01	0.916	0	0
Imatinib-resistant KIT mutants	R-HSA-9669917	1.214505e-01	0.916	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.214505e-01	0.916	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.214505e-01	0.916	0	0
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	1.214505e-01	0.916	0	0
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.214505e-01	0.916	0	0
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.214505e-01	0.916	0	0
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.214505e-01	0.916	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.231773e-01	0.909	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.236613e-01	0.908	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.249227e-01	0.903	0	0
ERK/MAPK targets	R-HSA-198753	1.250881e-01	0.903	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.259303e-01	0.900	0	0
Signaling by FGFR1 amplification mutants	R-HSA-1839120	1.377225e-01	0.861	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	1.377225e-01	0.861	0	0
MET interacts with TNS proteins	R-HSA-8875513	1.377225e-01	0.861	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	1.377225e-01	0.861	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	1.377225e-01	0.861	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.829052e-01	0.738	0	0
Regulation of gap junction activity	R-HSA-191650	1.829052e-01	0.738	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.829052e-01	0.738	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.829052e-01	0.738	0	0
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	1.829052e-01	0.738	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.829052e-01	0.738	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.829052e-01	0.738	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	1.416390e-01	0.849	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	1.416390e-01	0.849	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.416390e-01	0.849	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.723492e-01	0.764	0	0
RSK activation	R-HSA-444257	1.723492e-01	0.764	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	1.723492e-01	0.764	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.723492e-01	0.764	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.325113e-01	0.878	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.325113e-01	0.878	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.559480e-01	0.807	1	1
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.559480e-01	0.807	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	1.398157e-01	0.854	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.807893e-01	0.743	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	1.598356e-01	0.796	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.416827e-01	0.849	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.416827e-01	0.849	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.809346e-01	0.742	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.592309e-01	0.798	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.776650e-01	0.750	0	0
Activation of ATR in response to replication stress	R-HSA-176187	1.383598e-01	0.859	0	0
Striated Muscle Contraction	R-HSA-390522	1.524886e-01	0.817	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.728335e-01	0.762	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.728335e-01	0.762	0	0
Dual Incision in GG-NER	R-HSA-5696400	1.672780e-01	0.777	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	1.683386e-01	0.774	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.900005e-01	0.721	0	0
UCH proteinases	R-HSA-5689603	1.365301e-01	0.865	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	1.716053e-01	0.765	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.662179e-01	0.779	0	0
Signaling by SCF-KIT	R-HSA-1433557	1.313275e-01	0.882	0	0
Circadian clock	R-HSA-9909396	1.592151e-01	0.798	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.817379e-01	0.741	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.416827e-01	0.849	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.899442e-01	0.721	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.309614e-01	0.883	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.592309e-01	0.798	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.899442e-01	0.721	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	1.826929e-01	0.738	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	1.829052e-01	0.738	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.614197e-01	0.792	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.284226e-01	0.891	0	0
Dopamine receptors	R-HSA-390651	1.829052e-01	0.738	0	0
RNA Polymerase II Transcription	R-HSA-73857	1.697019e-01	0.770	1	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.407791e-01	0.851	1	1
Activation of BH3-only proteins	R-HSA-114452	1.899442e-01	0.721	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.807893e-01	0.743	0	0
TBC/RABGAPs	R-HSA-8854214	1.313275e-01	0.882	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	1.807893e-01	0.743	0	0
Disorders of Nervous System Development	R-HSA-9697154	1.559480e-01	0.807	0	0
Pervasive developmental disorders	R-HSA-9005895	1.559480e-01	0.807	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.559480e-01	0.807	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.807893e-01	0.743	0	0
Gap junction assembly	R-HSA-190861	1.672780e-01	0.777	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.377225e-01	0.861	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.325113e-01	0.878	0	0
Signaling by AXIN mutants	R-HSA-4839735	1.325113e-01	0.878	1	0
Signaling by TGFB family members	R-HSA-9006936	1.282869e-01	0.892	0	0
Signaling by ROBO receptors	R-HSA-376176	1.840084e-01	0.735	0	0
Signaling by Interleukins	R-HSA-449147	1.891568e-01	0.723	0	0
Assembly of the pre-replicative complex	R-HSA-68867	1.889413e-01	0.724	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.824821e-01	0.739	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.416390e-01	0.849	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.416827e-01	0.849	0	0
Inhibition of nitric oxide production	R-HSA-9636249	1.377225e-01	0.861	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	1.592309e-01	0.798	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	1.625082e-01	0.789	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	1.416390e-01	0.849	0	0
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	1.829052e-01	0.738	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.427751e-01	0.845	1	0
Sensory processing of sound	R-HSA-9659379	1.653188e-01	0.782	0	0
Inositol phosphate metabolism	R-HSA-1483249	1.908385e-01	0.719	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	1.775194e-01	0.751	0	0
Glucose metabolism	R-HSA-70326	1.910291e-01	0.719	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	1.959809e-01	0.708	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.969108e-01	0.706	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	1.969108e-01	0.706	0	0
mRNA Splicing	R-HSA-72172	1.975669e-01	0.704	0	0
Calmodulin induced events	R-HSA-111933	1.986944e-01	0.702	0	0
CaM pathway	R-HSA-111997	1.986944e-01	0.702	0	0
Homology Directed Repair	R-HSA-5693538	2.000364e-01	0.699	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	2.027829e-01	0.693	0	0
Germ layer formation at gastrulation	R-HSA-9754189	2.029956e-01	0.693	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	2.047184e-01	0.689	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.047184e-01	0.689	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	2.047184e-01	0.689	0	0
Regulation of KIT signaling	R-HSA-1433559	2.068303e-01	0.684	0	0
CRMPs in Sema3A signaling	R-HSA-399956	2.068303e-01	0.684	1	1
DNA Damage Bypass	R-HSA-73893	2.097411e-01	0.678	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.097411e-01	0.678	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.097411e-01	0.678	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	2.131874e-01	0.671	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.131874e-01	0.671	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	2.157047e-01	0.666	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	2.168886e-01	0.664	0	0
Long-term potentiation	R-HSA-9620244	2.168886e-01	0.664	0	0
Interleukin-7 signaling	R-HSA-1266695	2.168886e-01	0.664	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	2.258957e-01	0.646	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.260601e-01	0.646	0	0
Signaling by WNT in cancer	R-HSA-4791275	2.260601e-01	0.646	1	0
DNA strand elongation	R-HSA-69190	2.260601e-01	0.646	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.281569e-01	0.642	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.281569e-01	0.642	0	0
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.281569e-01	0.642	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.281569e-01	0.642	0	0
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.281569e-01	0.642	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.281569e-01	0.642	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	2.281569e-01	0.642	0	0
Inhibition of PKR	R-HSA-169131	2.281569e-01	0.642	0	0
Chromosome Maintenance	R-HSA-73886	2.282505e-01	0.642	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	2.298356e-01	0.639	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.298356e-01	0.639	0	0
G2 Phase	R-HSA-68911	2.298356e-01	0.639	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	2.298356e-01	0.639	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.298356e-01	0.639	0	0
DNA Replication Pre-Initiation	R-HSA-69002	2.299099e-01	0.638	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	3.219086e-01	0.492	0	0
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	3.219086e-01	0.492	0	0
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	3.219086e-01	0.492	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.219086e-01	0.492	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.219086e-01	0.492	0	0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	3.219086e-01	0.492	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	3.219086e-01	0.492	0	0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	3.219086e-01	0.492	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	3.219086e-01	0.492	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.219086e-01	0.492	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.219086e-01	0.492	0	0
Signaling by kinase domain mutants of KIT	R-HSA-9669933	3.219086e-01	0.492	0	0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	3.219086e-01	0.492	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.219086e-01	0.492	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	2.774234e-01	0.557	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	2.774234e-01	0.557	0	0
PDE3B signalling	R-HSA-165160	2.774234e-01	0.557	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	2.774234e-01	0.557	0	0
PKB-mediated events	R-HSA-109703	2.774234e-01	0.557	0	0
Signaling by MAPK mutants	R-HSA-9652817	2.774234e-01	0.557	0	0
Interaction between PHLDA1 and AURKA	R-HSA-8854521	4.042775e-01	0.393	0	0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	4.042775e-01	0.393	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	4.042775e-01	0.393	0	0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	4.042775e-01	0.393	0	0
Defective visual phototransduction due to ABCA4 loss of function	R-HSA-9918454	4.042775e-01	0.393	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.042775e-01	0.393	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	4.042775e-01	0.393	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	4.042775e-01	0.393	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.042775e-01	0.393	0	0
Pexophagy	R-HSA-9664873	2.383220e-01	0.623	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	2.383220e-01	0.623	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.248172e-01	0.488	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	2.727618e-01	0.564	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.727618e-01	0.564	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.338623e-01	0.631	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.338623e-01	0.631	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	3.076718e-01	0.512	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	3.713623e-01	0.430	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	3.713623e-01	0.430	0	0
SOS-mediated signalling	R-HSA-112412	3.713623e-01	0.430	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.495088e-01	0.603	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.900734e-01	0.537	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	2.375150e-01	0.624	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	3.427223e-01	0.465	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.427223e-01	0.465	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.188554e-01	0.496	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.165660e-01	0.380	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	4.165660e-01	0.380	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.165660e-01	0.380	0	0
MET receptor recycling	R-HSA-8875656	4.165660e-01	0.380	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	4.165660e-01	0.380	0	0
HIV elongation arrest and recovery	R-HSA-167287	2.803674e-01	0.552	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	2.803674e-01	0.552	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.478395e-01	0.459	0	0
GAB1 signalosome	R-HSA-180292	3.478395e-01	0.459	0	0
Ephrin signaling	R-HSA-3928664	3.478395e-01	0.459	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.478395e-01	0.459	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.840586e-01	0.547	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.840586e-01	0.547	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	2.676880e-01	0.572	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	2.413604e-01	0.617	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	2.413604e-01	0.617	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	3.485643e-01	0.458	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	3.768543e-01	0.424	0	0
ARMS-mediated activation	R-HSA-170984	4.600676e-01	0.337	0	0
WNT mediated activation of DVL	R-HSA-201688	4.600676e-01	0.337	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	4.600676e-01	0.337	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	2.866613e-01	0.543	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	3.473305e-01	0.459	0	0
Translation initiation complex formation	R-HSA-72649	2.865843e-01	0.543	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	4.057422e-01	0.392	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	4.057422e-01	0.392	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.849172e-01	0.545	0	0
Degradation of CDH1	R-HSA-9766229	3.215161e-01	0.493	0	0
Processive synthesis on the lagging strand	R-HSA-69183	4.459822e-01	0.351	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	4.459822e-01	0.351	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	2.689168e-01	0.570	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	2.835907e-01	0.547	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	3.193369e-01	0.496	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.927664e-01	0.406	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	4.243551e-01	0.372	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	4.243551e-01	0.372	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	4.243551e-01	0.372	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	3.751479e-01	0.426	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	4.074496e-01	0.390	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.074496e-01	0.390	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.932212e-01	0.405	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.932212e-01	0.405	1	1
Transcription of the HIV genome	R-HSA-167172	3.969541e-01	0.401	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.131829e-01	0.384	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	4.489337e-01	0.348	0	0
HIV Transcription Initiation	R-HSA-167161	4.489337e-01	0.348	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	4.489337e-01	0.348	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.800063e-01	0.553	0	0
FOXO-mediated transcription	R-HSA-9614085	4.553554e-01	0.342	0	0
EPH-Ephrin signaling	R-HSA-2682334	3.458804e-01	0.461	0	0
Interleukin-15 signaling	R-HSA-8983432	3.427223e-01	0.465	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	3.045049e-01	0.516	0	0
Cyclin D associated events in G1	R-HSA-69231	3.614931e-01	0.442	0	0
G1 Phase	R-HSA-69236	3.614931e-01	0.442	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	4.193912e-01	0.377	0	0
DNA Double Strand Break Response	R-HSA-5693606	2.705345e-01	0.568	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	2.383220e-01	0.623	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.478395e-01	0.459	0	0
HCMV Early Events	R-HSA-9609690	2.977650e-01	0.526	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	2.616776e-01	0.582	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.188554e-01	0.496	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.485643e-01	0.458	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	3.329501e-01	0.478	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.140674e-01	0.383	0	0
EPHB-mediated forward signaling	R-HSA-3928662	2.365527e-01	0.626	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	2.900734e-01	0.537	0	0
Specification of the neural plate border	R-HSA-9834899	3.768543e-01	0.424	0	0
Developmental Cell Lineages	R-HSA-9734767	4.328399e-01	0.364	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	3.932212e-01	0.405	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.700123e-01	0.432	0	0
Nephrin family interactions	R-HSA-373753	4.057422e-01	0.392	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.600676e-01	0.337	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.698715e-01	0.569	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.900734e-01	0.537	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.713623e-01	0.430	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	2.322865e-01	0.634	0	0
Stabilization of p53	R-HSA-69541	2.497852e-01	0.602	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.600676e-01	0.337	0	0
Interleukin-21 signaling	R-HSA-9020958	4.600676e-01	0.337	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	3.807605e-01	0.419	0	0
Myogenesis	R-HSA-525793	3.991687e-01	0.399	0	0
Interleukin-9 signaling	R-HSA-8985947	4.165660e-01	0.380	0	0
Resolution of D-Loop Structures	R-HSA-5693537	2.643005e-01	0.578	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.245241e-01	0.489	0	0
RNA Polymerase III Transcription	R-HSA-74158	3.245241e-01	0.489	0	0
NF-kB is activated and signals survival	R-HSA-209560	3.076718e-01	0.512	0	0
Adrenoceptors	R-HSA-390696	4.165660e-01	0.380	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.165660e-01	0.380	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.449461e-01	0.611	0	0
PKA activation	R-HSA-163615	3.478395e-01	0.459	0	0
Meiosis	R-HSA-1500620	4.287995e-01	0.368	0	0
Prolonged ERK activation events	R-HSA-169893	2.616776e-01	0.582	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	3.991687e-01	0.399	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.282375e-01	0.368	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.431476e-01	0.614	0	0
Generic Transcription Pathway	R-HSA-212436	3.046247e-01	0.516	1	0
DAG and IP3 signaling	R-HSA-1489509	2.529117e-01	0.597	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	4.343599e-01	0.362	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.031779e-01	0.518	1	0
Ca-dependent events	R-HSA-111996	3.233170e-01	0.490	0	0
PLC beta mediated events	R-HSA-112043	4.038842e-01	0.394	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	3.444325e-01	0.463	0	0
Synthesis of PI	R-HSA-1483226	2.727618e-01	0.564	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.431678e-01	0.614	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.927664e-01	0.406	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.343599e-01	0.362	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	4.154818e-01	0.381	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.525569e-01	0.453	1	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.294192e-01	0.367	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	3.412899e-01	0.467	0	0
Signaling by WNT	R-HSA-195721	3.490821e-01	0.457	1	0
G-protein mediated events	R-HSA-112040	3.807605e-01	0.419	0	0
Signaling by NOTCH3	R-HSA-9012852	4.294239e-01	0.367	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.900734e-01	0.537	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	3.768543e-01	0.424	0	0
Signal transduction by L1	R-HSA-445144	4.057422e-01	0.392	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	3.427223e-01	0.465	0	0
Toll-like Receptor Cascades	R-HSA-168898	2.554316e-01	0.593	0	0
DNA Replication	R-HSA-69306	2.980658e-01	0.526	0	0
p75NTR signals via NF-kB	R-HSA-193639	2.338623e-01	0.631	0	0
Frs2-mediated activation	R-HSA-170968	3.776211e-01	0.423	0	0
Interferon Signaling	R-HSA-913531	3.719304e-01	0.430	0	0
Formation of intermediate mesoderm	R-HSA-9761174	2.383220e-01	0.623	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	4.121137e-01	0.385	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.991687e-01	0.399	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	4.380972e-01	0.358	0	0
Ca2+ pathway	R-HSA-4086398	3.596827e-01	0.444	0	0
Mismatch Repair	R-HSA-5358508	3.478395e-01	0.459	0	0
Metabolism of RNA	R-HSA-8953854	4.298477e-01	0.367	0	0
Signal attenuation	R-HSA-74749	2.383220e-01	0.623	0	0
Neurofascin interactions	R-HSA-447043	3.248172e-01	0.488	0	0
Signalling to ERKs	R-HSA-187687	3.041549e-01	0.517	0	0
p75NTR recruits signalling complexes	R-HSA-209543	3.427223e-01	0.465	0	0
Platelet sensitization by LDL	R-HSA-432142	3.478395e-01	0.459	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	3.836151e-01	0.416	0	0
RAF/MAP kinase cascade	R-HSA-5673001	2.328390e-01	0.633	0	0
Hedgehog 'off' state	R-HSA-5610787	2.765935e-01	0.558	1	0
MAPK1/MAPK3 signaling	R-HSA-5684996	2.798962e-01	0.553	0	0
Interleukin-1 family signaling	R-HSA-446652	3.630747e-01	0.440	0	0
Transport of connexins along the secretory pathway	R-HSA-190827	3.219086e-01	0.492	0	0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	3.219086e-01	0.492	0	0
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	3.219086e-01	0.492	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.219086e-01	0.492	0	0
Manipulation of host energy metabolism	R-HSA-9636667	3.219086e-01	0.492	0	0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	3.219086e-01	0.492	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	4.042775e-01	0.393	0	0
C6 deamination of adenosine	R-HSA-75102	4.042775e-01	0.393	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	4.042775e-01	0.393	0	0
Signalling to ERK5	R-HSA-198765	4.042775e-01	0.393	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	2.616776e-01	0.582	0	0
Regulation of PTEN localization	R-HSA-8948747	3.713623e-01	0.430	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.165660e-01	0.380	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	4.165660e-01	0.380	0	0
PKA activation in glucagon signalling	R-HSA-164378	3.478395e-01	0.459	0	0
Ovarian tumor domain proteases	R-HSA-5689896	3.451012e-01	0.462	0	0
Orc1 removal from chromatin	R-HSA-68949	3.751479e-01	0.426	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	3.697793e-01	0.432	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	4.343599e-01	0.362	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	3.932212e-01	0.405	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	3.700123e-01	0.432	0	0
Signaling by FGFR in disease	R-HSA-1226099	2.698715e-01	0.569	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	3.368674e-01	0.473	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	4.456357e-01	0.351	0	0
Other semaphorin interactions	R-HSA-416700	4.459822e-01	0.351	0	0
NGF-stimulated transcription	R-HSA-9031628	3.039711e-01	0.517	0	0
Reproduction	R-HSA-1474165	4.305986e-01	0.366	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	4.020499e-01	0.396	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.248172e-01	0.488	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	2.983649e-01	0.525	0	0
CHL1 interactions	R-HSA-447041	3.713623e-01	0.430	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	2.495088e-01	0.603	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	4.600676e-01	0.337	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	4.459822e-01	0.351	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.489337e-01	0.348	1	1
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.489337e-01	0.348	1	1
SARS-CoV-2-host interactions	R-HSA-9705683	3.269502e-01	0.486	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.357388e-01	0.474	0	0
Signaling by Leptin	R-HSA-2586552	2.383220e-01	0.623	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.478395e-01	0.459	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.423299e-01	0.466	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	4.343599e-01	0.362	0	0
Oligomerization of connexins into connexons	R-HSA-190704	3.219086e-01	0.492	0	0
Inhibition of membrane repair	R-HSA-9635644	3.219086e-01	0.492	0	0
Diseases of cellular response to stress	R-HSA-9675132	4.042775e-01	0.393	0	0
Diseases of Cellular Senescence	R-HSA-9630747	4.042775e-01	0.393	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	2.495088e-01	0.603	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	3.485643e-01	0.458	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	4.121137e-01	0.385	0	0
Potential therapeutics for SARS	R-HSA-9679191	2.692474e-01	0.570	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	3.625894e-01	0.441	0	0
Diseases of DNA repair	R-HSA-9675135	4.000718e-01	0.398	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.143274e-01	0.503	0	0
Signaling by TGFBR3	R-HSA-9839373	2.696279e-01	0.569	0	0
Signal regulatory protein family interactions	R-HSA-391160	4.121137e-01	0.385	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.474778e-01	0.349	0	0
RMTs methylate histone arginines	R-HSA-3214858	3.614931e-01	0.442	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	3.991687e-01	0.399	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	4.586404e-01	0.339	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	4.600676e-01	0.337	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	4.459822e-01	0.351	0	0
IRE1alpha activates chaperones	R-HSA-381070	2.427369e-01	0.615	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	2.449461e-01	0.611	0	0
HDL assembly	R-HSA-8963896	4.121137e-01	0.385	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	4.605443e-01	0.337	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.625792e-01	0.335	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.678054e-01	0.330	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	4.678054e-01	0.330	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.694860e-01	0.328	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	4.720554e-01	0.326	0	0
DARPP-32 events	R-HSA-180024	4.740241e-01	0.324	0	0
MET activates STAT3	R-HSA-8875791	4.766451e-01	0.322	0	0
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	4.766451e-01	0.322	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	4.766451e-01	0.322	0	0
Defective gamma-carboxylation of F9	R-HSA-9673240	4.766451e-01	0.322	0	0
MET activates PTPN11	R-HSA-8865999	4.766451e-01	0.322	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	4.766451e-01	0.322	0	0
Invadopodia formation	R-HSA-8941237	4.766451e-01	0.322	0	0
Signalling to STAT3	R-HSA-198745	4.766451e-01	0.322	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	4.766451e-01	0.322	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.766451e-01	0.322	0	0
The NLRP1 inflammasome	R-HSA-844455	4.766451e-01	0.322	0	0
Co-inhibition by PD-1	R-HSA-389948	4.768812e-01	0.322	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	4.790435e-01	0.320	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	4.790435e-01	0.320	0	0
Killing mechanisms	R-HSA-9664420	4.790435e-01	0.320	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	4.790435e-01	0.320	0	0
Differentiation of T cells	R-HSA-9945266	4.790435e-01	0.320	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	4.790435e-01	0.320	0	0
Negative regulation of FLT3	R-HSA-9706369	4.790435e-01	0.320	0	0
RUNX2 regulates bone development	R-HSA-8941326	4.827596e-01	0.316	0	0
Interleukin-1 signaling	R-HSA-9020702	4.827600e-01	0.316	0	0
Dual incision in TC-NER	R-HSA-6782135	4.833120e-01	0.316	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	4.898452e-01	0.310	0	0
Signaling by NOTCH4	R-HSA-9013694	4.939080e-01	0.306	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	4.963991e-01	0.304	0	0
2-LTR circle formation	R-HSA-164843	5.016137e-01	0.300	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	5.016137e-01	0.300	0	0
PI3K/AKT activation	R-HSA-198203	5.016137e-01	0.300	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	5.016137e-01	0.300	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	5.016137e-01	0.300	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	5.016137e-01	0.300	0	0
Josephin domain DUBs	R-HSA-5689877	5.016137e-01	0.300	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	5.046844e-01	0.297	0	0
Degradation of DVL	R-HSA-4641258	5.046844e-01	0.297	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	5.070234e-01	0.295	0	0
Netrin-1 signaling	R-HSA-373752	5.099657e-01	0.292	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.111469e-01	0.291	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	5.111469e-01	0.291	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	5.131606e-01	0.290	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.173835e-01	0.286	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.173835e-01	0.286	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	5.173835e-01	0.286	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.173835e-01	0.286	0	0
Syndecan interactions	R-HSA-3000170	5.173835e-01	0.286	0	0
Growth hormone receptor signaling	R-HSA-982772	5.173835e-01	0.286	0	0
Downstream signal transduction	R-HSA-186763	5.222169e-01	0.282	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	5.222169e-01	0.282	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	5.233760e-01	0.281	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	5.255326e-01	0.279	0	0
MET promotes cell motility	R-HSA-8875878	5.262653e-01	0.279	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	5.262653e-01	0.279	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	5.298051e-01	0.276	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	5.298051e-01	0.276	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	5.298051e-01	0.276	0	0
Smooth Muscle Contraction	R-HSA-445355	5.329846e-01	0.273	0	0
Formation of paraxial mesoderm	R-HSA-9793380	5.358929e-01	0.271	0	0
Signaling by MAP2K mutants	R-HSA-9652169	5.402253e-01	0.267	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	5.402253e-01	0.267	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	5.402253e-01	0.267	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.402253e-01	0.267	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	5.402253e-01	0.267	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	5.402253e-01	0.267	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	5.402253e-01	0.267	0	0
NADE modulates death signalling	R-HSA-205025	5.402253e-01	0.267	0	0
Vasopressin-like receptors	R-HSA-388479	5.402253e-01	0.267	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	5.410374e-01	0.267	0	0
Formation of the posterior neural plate	R-HSA-9832991	5.410374e-01	0.267	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	5.410374e-01	0.267	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	5.410374e-01	0.267	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	5.421718e-01	0.266	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	5.421718e-01	0.266	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	5.421718e-01	0.266	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	5.421718e-01	0.266	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	5.421718e-01	0.266	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	5.421718e-01	0.266	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	5.421718e-01	0.266	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	5.421718e-01	0.266	0	0
Protein-protein interactions at synapses	R-HSA-6794362	5.434897e-01	0.265	0	0
Plasma lipoprotein assembly	R-HSA-8963898	5.437852e-01	0.265	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	5.474539e-01	0.262	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.474539e-01	0.262	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	5.493246e-01	0.260	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.529907e-01	0.257	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	5.565058e-01	0.255	0	0
RNA Polymerase I Transcription	R-HSA-73864	5.565058e-01	0.255	0	0
HIV Transcription Elongation	R-HSA-167169	5.682070e-01	0.245	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	5.682070e-01	0.245	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	5.682070e-01	0.245	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	5.682070e-01	0.245	0	0
Integrin signaling	R-HSA-354192	5.684013e-01	0.245	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	5.684013e-01	0.245	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	5.684891e-01	0.245	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	5.684891e-01	0.245	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	5.694209e-01	0.245	0	0
Signaling by NOTCH	R-HSA-157118	5.695446e-01	0.244	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	5.698307e-01	0.244	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	5.707222e-01	0.244	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	5.720244e-01	0.243	0	0
Nephron development	R-HSA-9831926	5.720244e-01	0.243	0	0
Gene Silencing by RNA	R-HSA-211000	5.760254e-01	0.240	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.782414e-01	0.238	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.782414e-01	0.238	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	5.782414e-01	0.238	0	0
PI3K events in ERBB4 signaling	R-HSA-1250342	5.782414e-01	0.238	0	0
Integration of provirus	R-HSA-162592	5.782414e-01	0.238	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.782414e-01	0.238	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	5.782414e-01	0.238	0	0
Activation of RAC1	R-HSA-428540	5.782414e-01	0.238	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	5.782414e-01	0.238	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.782414e-01	0.238	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	5.782414e-01	0.238	0	0
ERKs are inactivated	R-HSA-202670	5.782414e-01	0.238	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	5.875749e-01	0.231	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	5.884864e-01	0.230	0	0
FLT3 Signaling	R-HSA-9607240	5.884864e-01	0.230	0	0
SARS-CoV Infections	R-HSA-9679506	5.901795e-01	0.229	1	0
Glucagon signaling in metabolic regulation	R-HSA-163359	5.906087e-01	0.229	0	0
Metalloprotease DUBs	R-HSA-5689901	5.942323e-01	0.226	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.942323e-01	0.226	0	0
TRP channels	R-HSA-3295583	5.942323e-01	0.226	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.942323e-01	0.226	0	0
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	5.960846e-01	0.225	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	5.960846e-01	0.225	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	5.960846e-01	0.225	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.960846e-01	0.225	0	0
PTK6 Activates STAT3	R-HSA-8849474	5.960846e-01	0.225	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.960846e-01	0.225	0	0
Activation of AKT2	R-HSA-165158	5.960846e-01	0.225	0	0
Reelin signalling pathway	R-HSA-8866376	5.960846e-01	0.225	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.960846e-01	0.225	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	5.960846e-01	0.225	0	0
Co-inhibition by BTLA	R-HSA-9927353	5.960846e-01	0.225	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	5.960846e-01	0.225	0	0
NrCAM interactions	R-HSA-447038	5.960846e-01	0.225	0	0
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	5.960846e-01	0.225	0	0
Regulation of signaling by CBL	R-HSA-912631	6.006355e-01	0.221	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	6.006355e-01	0.221	0	0
STING mediated induction of host immune responses	R-HSA-1834941	6.006355e-01	0.221	0	0
Diseases of programmed cell death	R-HSA-9645723	6.011872e-01	0.221	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	6.121711e-01	0.213	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	6.121711e-01	0.213	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	6.121711e-01	0.213	0	0
Mitophagy	R-HSA-5205647	6.121711e-01	0.213	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	6.131830e-01	0.212	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	6.131830e-01	0.212	0	0
VLDLR internalisation and degradation	R-HSA-8866427	6.131830e-01	0.212	0	0
Regulation of IFNG signaling	R-HSA-877312	6.131830e-01	0.212	0	0
OAS antiviral response	R-HSA-8983711	6.131830e-01	0.212	0	0
Signaling by ERBB4	R-HSA-1236394	6.170334e-01	0.210	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.181733e-01	0.209	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	6.181733e-01	0.209	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	6.181733e-01	0.209	0	0
Regulation of RAS by GAPs	R-HSA-5658442	6.235530e-01	0.205	0	0
PI3K Cascade	R-HSA-109704	6.235530e-01	0.205	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	6.274962e-01	0.202	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	6.279571e-01	0.202	0	0
Co-inhibition by CTLA4	R-HSA-389513	6.279571e-01	0.202	0	0
Signaling by NODAL	R-HSA-1181150	6.279571e-01	0.202	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	6.330560e-01	0.199	0	0
Regulation of Apoptosis	R-HSA-169911	6.330560e-01	0.199	0	0
PERK regulates gene expression	R-HSA-381042	6.330560e-01	0.199	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	6.382306e-01	0.195	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	6.410153e-01	0.193	0	0
Meiotic recombination	R-HSA-912446	6.410153e-01	0.193	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	6.412086e-01	0.193	0	0
Formation of the Early Elongation Complex	R-HSA-113418	6.412086e-01	0.193	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	6.412086e-01	0.193	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	6.412086e-01	0.193	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	6.412086e-01	0.193	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	6.421475e-01	0.192	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.451603e-01	0.190	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.451603e-01	0.190	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	6.451603e-01	0.190	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	6.451603e-01	0.190	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.451603e-01	0.190	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.451603e-01	0.190	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.451603e-01	0.190	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.451603e-01	0.190	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	6.451603e-01	0.190	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.451603e-01	0.190	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.451603e-01	0.190	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	6.458267e-01	0.190	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	6.458629e-01	0.190	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	6.458629e-01	0.190	0	0
Interleukin-6 signaling	R-HSA-1059683	6.458629e-01	0.190	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	6.458629e-01	0.190	0	0
Interleukin-12 signaling	R-HSA-9020591	6.464525e-01	0.189	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	6.532377e-01	0.185	0	0
FLT3 signaling in disease	R-HSA-9682385	6.532377e-01	0.185	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	6.539603e-01	0.184	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	6.539603e-01	0.184	0	0
Lagging Strand Synthesis	R-HSA-69186	6.539603e-01	0.184	0	0
Influenza Infection	R-HSA-168255	6.545860e-01	0.184	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	6.579986e-01	0.182	0	0
mRNA Capping	R-HSA-72086	6.633130e-01	0.178	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	6.633130e-01	0.178	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	6.642737e-01	0.178	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	6.688163e-01	0.175	0	0
Amino acids regulate mTORC1	R-HSA-9639288	6.744879e-01	0.171	0	0
Meiotic synapsis	R-HSA-1221632	6.744879e-01	0.171	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.763147e-01	0.170	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	6.763147e-01	0.170	0	0
Removal of the Flap Intermediate	R-HSA-69166	6.763147e-01	0.170	0	0
Retrograde neurotrophin signalling	R-HSA-177504	6.763147e-01	0.170	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	6.763147e-01	0.170	0	0
Zinc transporters	R-HSA-435354	6.763147e-01	0.170	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	6.763147e-01	0.170	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	6.786324e-01	0.168	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	6.786324e-01	0.168	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	6.786324e-01	0.168	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	6.788189e-01	0.168	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	6.817793e-01	0.166	0	0
Fanconi Anemia Pathway	R-HSA-6783310	6.817793e-01	0.166	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	6.817793e-01	0.166	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	6.844707e-01	0.165	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.846674e-01	0.165	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.881420e-01	0.162	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.882758e-01	0.162	0	0
Signaling by LTK in cancer	R-HSA-9842640	6.882758e-01	0.162	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.882758e-01	0.162	0	0
Erythropoietin activates STAT5	R-HSA-9027283	6.882758e-01	0.162	0	0
Autointegration results in viral DNA circles	R-HSA-177539	6.882758e-01	0.162	0	0
G2/M DNA replication checkpoint	R-HSA-69478	6.882758e-01	0.162	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	6.882758e-01	0.162	0	0
Nef and signal transduction	R-HSA-164944	6.882758e-01	0.162	0	0
Leukotriene receptors	R-HSA-391906	6.882758e-01	0.162	0	0
Interleukin-12 family signaling	R-HSA-447115	6.968865e-01	0.157	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.986798e-01	0.156	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	7.019746e-01	0.154	0	0
FGFR2 alternative splicing	R-HSA-6803529	7.019746e-01	0.154	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.019746e-01	0.154	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	7.019746e-01	0.154	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	7.045973e-01	0.152	0	0
Erythropoietin activates RAS	R-HSA-9027284	7.045973e-01	0.152	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	7.045973e-01	0.152	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	7.045973e-01	0.152	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	7.045973e-01	0.152	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	7.045973e-01	0.152	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	7.045973e-01	0.152	0	0
Spry regulation of FGF signaling	R-HSA-1295596	7.045973e-01	0.152	0	0
Formation of the anterior neural plate	R-HSA-9823739	7.045973e-01	0.152	0	0
p38MAPK events	R-HSA-171007	7.045973e-01	0.152	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	7.046738e-01	0.152	0	0
Trafficking of AMPA receptors	R-HSA-399719	7.046738e-01	0.152	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	7.046738e-01	0.152	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	7.093953e-01	0.149	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	7.093953e-01	0.149	0	0
TCR signaling	R-HSA-202403	7.095055e-01	0.149	0	0
IGF1R signaling cascade	R-HSA-2428924	7.130621e-01	0.147	0	0
Insulin receptor signalling cascade	R-HSA-74751	7.130621e-01	0.147	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	7.142034e-01	0.146	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.239218e-01	0.140	0	0
Interleukin receptor SHC signaling	R-HSA-912526	7.240002e-01	0.140	0	0
Opioid Signalling	R-HSA-111885	7.240587e-01	0.140	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	7.261547e-01	0.139	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.261547e-01	0.139	0	0
DAG1 core M1 glycosylations	R-HSA-8932506	7.261547e-01	0.139	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.261547e-01	0.139	0	0
Recycling of eIF2:GDP	R-HSA-72731	7.261547e-01	0.139	0	0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	7.261547e-01	0.139	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	7.261547e-01	0.139	0	0
Disinhibition of SNARE formation	R-HSA-114516	7.261547e-01	0.139	0	0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	7.261547e-01	0.139	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	7.261547e-01	0.139	0	0
PTK6 Expression	R-HSA-8849473	7.261547e-01	0.139	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	7.261547e-01	0.139	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	7.261547e-01	0.139	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	7.261547e-01	0.139	0	0
Synthesis of PIPs in the nucleus	R-HSA-8847453	7.261547e-01	0.139	0	0
VLDL clearance	R-HSA-8964046	7.261547e-01	0.139	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	7.261547e-01	0.139	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	7.261547e-01	0.139	0	0
Interleukin-2 family signaling	R-HSA-451927	7.266228e-01	0.139	0	0
Generation of second messenger molecules	R-HSA-202433	7.266228e-01	0.139	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	7.269086e-01	0.139	0	0
Cellular response to hypoxia	R-HSA-1234174	7.269086e-01	0.139	0	0
Cellular response to chemical stress	R-HSA-9711123	7.290707e-01	0.137	1	0
GPER1 signaling	R-HSA-9634597	7.306378e-01	0.136	0	0
Intraflagellar transport	R-HSA-5620924	7.306378e-01	0.136	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	7.307883e-01	0.136	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	7.307883e-01	0.136	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.307883e-01	0.136	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	7.307883e-01	0.136	0	0
Base Excision Repair	R-HSA-73884	7.331771e-01	0.135	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	7.349078e-01	0.134	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	7.349078e-01	0.134	0	0
IRS-mediated signalling	R-HSA-112399	7.353070e-01	0.134	0	0
G-protein beta:gamma signalling	R-HSA-397795	7.422206e-01	0.129	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.422206e-01	0.129	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	7.422206e-01	0.129	0	0
Protein ubiquitination	R-HSA-8852135	7.454244e-01	0.128	0	0
Adaptive Immune System	R-HSA-1280218	7.475960e-01	0.126	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	7.505860e-01	0.125	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	7.549782e-01	0.122	0	0
Phase 2 - plateau phase	R-HSA-5576893	7.549782e-01	0.122	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	7.549782e-01	0.122	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.588363e-01	0.120	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	7.588363e-01	0.120	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.594327e-01	0.120	0	0
DAG1 core M2 glycosylations	R-HSA-8932504	7.594327e-01	0.120	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	7.594327e-01	0.120	0	0
FGFR1b ligand binding and activation	R-HSA-190370	7.594327e-01	0.120	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.594327e-01	0.120	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.594327e-01	0.120	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.594327e-01	0.120	0	0
Interleukin-23 signaling	R-HSA-9020933	7.594327e-01	0.120	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	7.594327e-01	0.120	0	0
Regulation by c-FLIP	R-HSA-3371378	7.594327e-01	0.120	0	0
Dimerization of procaspase-8	R-HSA-69416	7.594327e-01	0.120	0	0
SLC-mediated bile acid transport	R-HSA-9958517	7.594327e-01	0.120	0	0
Sodium/Proton exchangers	R-HSA-425986	7.594327e-01	0.120	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	7.595817e-01	0.119	0	0
Vpu mediated degradation of CD4	R-HSA-180534	7.595817e-01	0.119	0	0
Extension of Telomeres	R-HSA-180786	7.625674e-01	0.118	0	0
Formation of the nephric duct	R-HSA-9830364	7.642011e-01	0.117	0	0
Transmission across Chemical Synapses	R-HSA-112315	7.686079e-01	0.114	0	0
HCMV Infection	R-HSA-9609646	7.731275e-01	0.112	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	7.739480e-01	0.111	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.754097e-01	0.110	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	7.760214e-01	0.110	0	0
Signaling by NOTCH2	R-HSA-1980145	7.760214e-01	0.110	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.760214e-01	0.110	1	1
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.772666e-01	0.109	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	7.772666e-01	0.109	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	7.772666e-01	0.109	0	0
PCP/CE pathway	R-HSA-4086400	7.805160e-01	0.108	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	7.809123e-01	0.107	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	7.824449e-01	0.107	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	7.824449e-01	0.107	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.824449e-01	0.107	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	7.824449e-01	0.107	0	0
Suppression of phagosomal maturation	R-HSA-9637687	7.824449e-01	0.107	0	0
Signaling by Hedgehog	R-HSA-5358351	7.846180e-01	0.105	1	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	7.871649e-01	0.104	0	0
Neurexins and neuroligins	R-HSA-6794361	7.871649e-01	0.104	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	7.871649e-01	0.104	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	7.881082e-01	0.103	0	0
MAPK1 (ERK2) activation	R-HSA-112411	7.886684e-01	0.103	0	0
CASP8 activity is inhibited	R-HSA-5218900	7.886684e-01	0.103	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.886684e-01	0.103	0	0
Lipophagy	R-HSA-9613354	7.886684e-01	0.103	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	7.886684e-01	0.103	0	0
p75NTR regulates axonogenesis	R-HSA-193697	7.886684e-01	0.103	0	0
mRNA Editing	R-HSA-75072	7.886684e-01	0.103	0	0
Regulation of signaling by NODAL	R-HSA-1433617	7.886684e-01	0.103	0	0
GP1b-IX-V activation signalling	R-HSA-430116	7.886684e-01	0.103	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.886684e-01	0.103	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	7.886684e-01	0.103	0	0
Interleukin-1 processing	R-HSA-448706	7.886684e-01	0.103	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.886684e-01	0.103	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	7.886684e-01	0.103	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	7.899460e-01	0.102	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	7.915599e-01	0.102	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.967940e-01	0.099	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	7.977583e-01	0.098	0	0
FGFR1 ligand binding and activation	R-HSA-190242	7.977583e-01	0.098	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	7.977583e-01	0.098	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	7.977583e-01	0.098	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	7.977583e-01	0.098	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	7.995058e-01	0.097	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.995058e-01	0.097	0	0
Signaling by PDGF	R-HSA-186797	7.995397e-01	0.097	0	0
Hedgehog 'on' state	R-HSA-5632684	8.003559e-01	0.097	0	0
Amine ligand-binding receptors	R-HSA-375280	8.016700e-01	0.096	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	8.062210e-01	0.094	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.062210e-01	0.094	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	8.143527e-01	0.089	0	0
Folding of actin by CCT/TriC	R-HSA-390450	8.143527e-01	0.089	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	8.143527e-01	0.089	0	0
Binding and entry of HIV virion	R-HSA-173107	8.143527e-01	0.089	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	8.143527e-01	0.089	0	0
DNA replication initiation	R-HSA-68952	8.143527e-01	0.089	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	8.143527e-01	0.089	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	8.143527e-01	0.089	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	8.143527e-01	0.089	0	0
Interleukin-27 signaling	R-HSA-9020956	8.143527e-01	0.089	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.143527e-01	0.089	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	8.143527e-01	0.089	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	8.145363e-01	0.089	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.145363e-01	0.089	0	0
Somitogenesis	R-HSA-9824272	8.145363e-01	0.089	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	8.153430e-01	0.089	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	8.154304e-01	0.089	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.165607e-01	0.088	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	8.165607e-01	0.088	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	8.165607e-01	0.088	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	8.165607e-01	0.088	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.165607e-01	0.088	0	0
Degradation of AXIN	R-HSA-4641257	8.200311e-01	0.086	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.200311e-01	0.086	1	1
Ion transport by P-type ATPases	R-HSA-936837	8.216430e-01	0.085	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	8.216430e-01	0.085	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	8.267248e-01	0.083	0	0
Signaling by Erythropoietin	R-HSA-9006335	8.302676e-01	0.081	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.302676e-01	0.081	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.315437e-01	0.080	0	0
Regulation of insulin secretion	R-HSA-422356	8.325971e-01	0.080	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.337817e-01	0.079	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	8.337817e-01	0.079	0	0
Integration of energy metabolism	R-HSA-163685	8.346961e-01	0.078	0	0
DAG1 core M3 glycosylations	R-HSA-8932505	8.369167e-01	0.077	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.369167e-01	0.077	0	0
LGI-ADAM interactions	R-HSA-5682910	8.369167e-01	0.077	0	0
Interleukin-2 signaling	R-HSA-9020558	8.369167e-01	0.077	0	0
vRNA Synthesis	R-HSA-192814	8.369167e-01	0.077	0	0
Bicarbonate transporters	R-HSA-425381	8.369167e-01	0.077	0	0
Chylomicron assembly	R-HSA-8963888	8.369167e-01	0.077	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.369167e-01	0.077	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.369167e-01	0.077	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	8.369167e-01	0.077	0	0
Suppression of apoptosis	R-HSA-9635465	8.369167e-01	0.077	0	0
PECAM1 interactions	R-HSA-210990	8.369167e-01	0.077	0	0
Transport of RCbl within the body	R-HSA-9758890	8.369167e-01	0.077	0	0
Prostanoid ligand receptors	R-HSA-391908	8.369167e-01	0.077	0	0
tRNA processing	R-HSA-72306	8.445720e-01	0.073	0	0
Muscle contraction	R-HSA-397014	8.462674e-01	0.072	0	0
Co-stimulation by CD28	R-HSA-389356	8.491478e-01	0.071	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	8.495278e-01	0.071	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	8.495278e-01	0.071	0	0
Basigin interactions	R-HSA-210991	8.495278e-01	0.071	0	0
Signalling to RAS	R-HSA-167044	8.495278e-01	0.071	0	0
Kidney development	R-HSA-9830369	8.511630e-01	0.070	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.566163e-01	0.067	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.566504e-01	0.067	0	0
Diseases of Immune System	R-HSA-5260271	8.566504e-01	0.067	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.566504e-01	0.067	0	0
Gamma-carboxylation of protein precursors	R-HSA-159740	8.567394e-01	0.067	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	8.567394e-01	0.067	0	0
Proton-coupled monocarboxylate transport	R-HSA-433692	8.567394e-01	0.067	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	8.567394e-01	0.067	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	8.639031e-01	0.064	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	8.639031e-01	0.064	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	8.648581e-01	0.063	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	8.648581e-01	0.063	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	8.648581e-01	0.063	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.673581e-01	0.062	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	8.673581e-01	0.062	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.673581e-01	0.062	0	0
SARS-CoV-1 Infection	R-HSA-9678108	8.727878e-01	0.059	1	0
GRB2 events in EGFR signaling	R-HSA-179812	8.741536e-01	0.058	0	0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	R-HSA-159854	8.741536e-01	0.058	0	0
Signaling by LTK	R-HSA-9842663	8.741536e-01	0.058	0	0
IRAK1 recruits IKK complex	R-HSA-937039	8.741536e-01	0.058	0	0
Polymerase switching	R-HSA-69091	8.741536e-01	0.058	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.741536e-01	0.058	0	0
Leading Strand Synthesis	R-HSA-69109	8.741536e-01	0.058	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	8.741536e-01	0.058	0	0
MET activates RAS signaling	R-HSA-8851805	8.741536e-01	0.058	0	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.741536e-01	0.058	0	0
Interleukin-35 Signalling	R-HSA-8984722	8.741536e-01	0.058	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.741536e-01	0.058	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	8.767518e-01	0.057	1	0
Signaling by KIT in disease	R-HSA-9669938	8.770082e-01	0.057	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	8.770082e-01	0.057	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	8.770082e-01	0.057	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.770082e-01	0.057	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.770082e-01	0.057	0	0
LDL clearance	R-HSA-8964038	8.770082e-01	0.057	0	0
HSF1-dependent transactivation	R-HSA-3371571	8.782230e-01	0.056	0	0
Regulation of necroptotic cell death	R-HSA-5675482	8.797724e-01	0.056	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	8.867905e-01	0.052	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.867905e-01	0.052	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	8.889393e-01	0.051	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	8.889393e-01	0.051	0	0
Interleukin-20 family signaling	R-HSA-8854691	8.889393e-01	0.051	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	8.894520e-01	0.051	0	0
FGFR1c ligand binding and activation	R-HSA-190373	8.894520e-01	0.051	0	0
Chylomicron remodeling	R-HSA-8963901	8.894520e-01	0.051	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.894520e-01	0.051	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.894520e-01	0.051	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	8.894520e-01	0.051	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.894520e-01	0.051	0	0
SARS-CoV-2 Infection	R-HSA-9694516	8.895849e-01	0.051	1	0
Effects of PIP2 hydrolysis	R-HSA-114508	8.899474e-01	0.051	0	0
Miscellaneous transport and binding events	R-HSA-5223345	8.899474e-01	0.051	0	0
Telomere Maintenance	R-HSA-157579	8.906253e-01	0.050	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.954437e-01	0.048	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	8.993438e-01	0.046	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	8.997881e-01	0.046	0	0
Interleukin-6 family signaling	R-HSA-6783589	8.997881e-01	0.046	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	8.997881e-01	0.046	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.012052e-01	0.045	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.023805e-01	0.045	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	9.028914e-01	0.044	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	9.028914e-01	0.044	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	9.028914e-01	0.044	0	0
Physiological factors	R-HSA-5578768	9.028914e-01	0.044	0	0
Proteasome assembly	R-HSA-9907900	9.035695e-01	0.044	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.062426e-01	0.043	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.062426e-01	0.043	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.080106e-01	0.042	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.083191e-01	0.042	0	0
Parasite infection	R-HSA-9664407	9.083191e-01	0.042	0	0
Leishmania phagocytosis	R-HSA-9664417	9.083191e-01	0.042	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.096415e-01	0.041	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	9.096415e-01	0.041	0	0
Tight junction interactions	R-HSA-420029	9.096415e-01	0.041	0	0
Acyl chain remodelling of PS	R-HSA-1482801	9.096415e-01	0.041	0	0
Laminin interactions	R-HSA-3000157	9.096415e-01	0.041	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.096415e-01	0.041	0	0
Cap-dependent Translation Initiation	R-HSA-72737	9.100788e-01	0.041	0	0
Eukaryotic Translation Initiation	R-HSA-72613	9.100788e-01	0.041	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.111312e-01	0.040	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.111312e-01	0.040	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.127500e-01	0.040	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.146976e-01	0.039	0	0
SHC1 events in EGFR signaling	R-HSA-180336	9.146976e-01	0.039	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	9.146976e-01	0.039	0	0
Translesion synthesis by REV1	R-HSA-110312	9.146976e-01	0.039	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	9.146976e-01	0.039	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	9.146976e-01	0.039	0	0
Signaling by Activin	R-HSA-1502540	9.146976e-01	0.039	0	0
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	9.146976e-01	0.039	0	0
Protein methylation	R-HSA-8876725	9.146976e-01	0.039	0	0
DNA Damage Reversal	R-HSA-73942	9.146976e-01	0.039	0	0
Mitochondrial biogenesis	R-HSA-1592230	9.148369e-01	0.039	0	0
Triglyceride catabolism	R-HSA-163560	9.159951e-01	0.038	0	0
Signaling by FGFR1	R-HSA-5654736	9.160667e-01	0.038	0	0
Ion homeostasis	R-HSA-5578775	9.160667e-01	0.038	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.185810e-01	0.037	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.233428e-01	0.035	0	0
Translesion synthesis by POLI	R-HSA-5656121	9.250691e-01	0.034	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.250691e-01	0.034	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	9.250691e-01	0.034	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	9.250691e-01	0.034	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.250691e-01	0.034	0	0
Triglyceride biosynthesis	R-HSA-75109	9.266832e-01	0.033	0	0
Insulin processing	R-HSA-264876	9.266832e-01	0.033	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.300973e-01	0.031	0	0
Gluconeogenesis	R-HSA-70263	9.307419e-01	0.031	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	9.310168e-01	0.031	0	0
RSV-host interactions	R-HSA-9833110	9.314754e-01	0.031	0	0
Triglyceride metabolism	R-HSA-8979227	9.334264e-01	0.030	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.340194e-01	0.030	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	9.340194e-01	0.030	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.340194e-01	0.030	0	0
Inflammasomes	R-HSA-622312	9.340194e-01	0.030	0	0
Translesion synthesis by POLK	R-HSA-5655862	9.341801e-01	0.030	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.341801e-01	0.030	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.341801e-01	0.030	0	0
Heme assimilation	R-HSA-9927020	9.341801e-01	0.030	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	9.341801e-01	0.030	0	0
tRNA modification in the mitochondrion	R-HSA-6787450	9.341801e-01	0.030	0	0
Synthesis of PG	R-HSA-1483148	9.341801e-01	0.030	0	0
Coenzyme A biosynthesis	R-HSA-196783	9.341801e-01	0.030	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	9.341801e-01	0.030	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.341801e-01	0.030	0	0
Plasma lipoprotein clearance	R-HSA-8964043	9.363001e-01	0.029	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	9.406561e-01	0.027	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.406561e-01	0.027	0	0
Downstream TCR signaling	R-HSA-202424	9.411899e-01	0.026	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.419908e-01	0.026	0	0
Glycogen metabolism	R-HSA-8982491	9.419908e-01	0.026	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.421837e-01	0.026	0	0
Glycogen storage diseases	R-HSA-3229121	9.421837e-01	0.026	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	9.421837e-01	0.026	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	9.421837e-01	0.026	0	0
Choline catabolism	R-HSA-6798163	9.421837e-01	0.026	0	0
Aquaporin-mediated transport	R-HSA-445717	9.431401e-01	0.025	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.431401e-01	0.025	1	1
Cellular response to starvation	R-HSA-9711097	9.443643e-01	0.025	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.463531e-01	0.024	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.466550e-01	0.024	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.466550e-01	0.024	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.472067e-01	0.024	0	0
Neddylation	R-HSA-8951664	9.474850e-01	0.023	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.475005e-01	0.023	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.489737e-01	0.023	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	9.492145e-01	0.023	0	0
Tie2 Signaling	R-HSA-210993	9.492145e-01	0.023	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.492145e-01	0.023	0	0
Intra-Golgi traffic	R-HSA-6811438	9.519833e-01	0.021	0	0
Signaling by Insulin receptor	R-HSA-74752	9.520244e-01	0.021	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.520244e-01	0.021	0	0
Cargo concentration in the ER	R-HSA-5694530	9.520729e-01	0.021	0	0
Phospholipid metabolism	R-HSA-1483257	9.530483e-01	0.021	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.533722e-01	0.021	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	9.553907e-01	0.020	0	0
Translesion Synthesis by POLH	R-HSA-110320	9.553907e-01	0.020	0	0
Pyrimidine biosynthesis	R-HSA-500753	9.553907e-01	0.020	0	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.553907e-01	0.020	0	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.553907e-01	0.020	0	0
Other interleukin signaling	R-HSA-449836	9.553907e-01	0.020	0	0
HDL remodeling	R-HSA-8964058	9.553907e-01	0.020	0	0
Maturation of nucleoprotein	R-HSA-9694631	9.553907e-01	0.020	1	1
The NLRP3 inflammasome	R-HSA-844456	9.553907e-01	0.020	0	0
Diseases of hemostasis	R-HSA-9671793	9.553907e-01	0.020	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.563537e-01	0.019	0	0
Signaling by FGFR4	R-HSA-5654743	9.603492e-01	0.018	0	0
PPARA activates gene expression	R-HSA-1989781	9.604846e-01	0.018	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	9.608161e-01	0.017	0	0
Glycogen synthesis	R-HSA-3322077	9.608161e-01	0.017	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.608161e-01	0.017	0	0
Protein hydroxylation	R-HSA-9629569	9.608161e-01	0.017	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.608637e-01	0.017	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.610330e-01	0.017	0	0
G alpha (z) signalling events	R-HSA-418597	9.621660e-01	0.017	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.629236e-01	0.016	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.646791e-01	0.016	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.653458e-01	0.015	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.653458e-01	0.015	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.653789e-01	0.015	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.655819e-01	0.015	0	0
G-protein activation	R-HSA-202040	9.655819e-01	0.015	0	0
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.655819e-01	0.015	0	0
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.655819e-01	0.015	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.655819e-01	0.015	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.666248e-01	0.015	0	0
Signaling by FGFR3	R-HSA-5654741	9.673307e-01	0.014	0	0
Platelet homeostasis	R-HSA-418346	9.680839e-01	0.014	0	0
eNOS activation	R-HSA-203615	9.689247e-01	0.014	0	0
Signal amplification	R-HSA-392518	9.689247e-01	0.014	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.689247e-01	0.014	0	0
Hyaluronan metabolism	R-HSA-2142845	9.689247e-01	0.014	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.689247e-01	0.014	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	9.689247e-01	0.014	0	0
ER-Phagosome pathway	R-HSA-1236974	9.693486e-01	0.014	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.697684e-01	0.013	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	9.697684e-01	0.013	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.697684e-01	0.013	0	0
Assembly Of The HIV Virion	R-HSA-175474	9.697684e-01	0.013	0	0
Signaling by FGFR	R-HSA-190236	9.706894e-01	0.013	0	0
Signaling by FGFR2	R-HSA-5654738	9.707366e-01	0.013	0	0
Neurotransmitter release cycle	R-HSA-112310	9.715727e-01	0.013	0	0
Stimuli-sensing channels	R-HSA-2672351	9.722043e-01	0.012	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.729580e-01	0.012	0	0
Synthesis of PC	R-HSA-1483191	9.731393e-01	0.012	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.734458e-01	0.012	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.734458e-01	0.012	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.734458e-01	0.012	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.735568e-01	0.012	0	0
Neuronal System	R-HSA-112316	9.743749e-01	0.011	0	0
PRC2 methylates histones and DNA	R-HSA-212300	9.750437e-01	0.011	0	0
HSF1 activation	R-HSA-3371511	9.750437e-01	0.011	0	0
Glycosphingolipid transport	R-HSA-9845576	9.750437e-01	0.011	0	0
GPVI-mediated activation cascade	R-HSA-114604	9.750437e-01	0.011	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.750437e-01	0.011	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.750437e-01	0.011	0	0
Metal ion SLC transporters	R-HSA-425410	9.756623e-01	0.011	0	0
tRNA Aminoacylation	R-HSA-379724	9.758534e-01	0.011	0	0
Metabolism of polyamines	R-HSA-351202	9.758534e-01	0.011	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.766761e-01	0.010	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.766761e-01	0.010	0	0
Carnitine shuttle	R-HSA-200425	9.766761e-01	0.010	0	0
Formation of the ureteric bud	R-HSA-9830674	9.766761e-01	0.010	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.769830e-01	0.010	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.770816e-01	0.010	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.776488e-01	0.010	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.776488e-01	0.010	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.784306e-01	0.009	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.790284e-01	0.009	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.790284e-01	0.009	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.795136e-01	0.009	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.795136e-01	0.009	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.795136e-01	0.009	0	0
Mitochondrial RNA degradation	R-HSA-9836573	9.795136e-01	0.009	0	0
TNFs bind their physiological receptors	R-HSA-5669034	9.795136e-01	0.009	0	0
Ribosome-associated quality control	R-HSA-9948299	9.797801e-01	0.009	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.799896e-01	0.009	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.799896e-01	0.009	0	0
HCMV Late Events	R-HSA-9610379	9.800215e-01	0.009	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	9.800480e-01	0.009	0	0
SLC transporter disorders	R-HSA-5619102	9.802770e-01	0.009	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.816681e-01	0.008	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.820060e-01	0.008	0	0
G protein gated Potassium channels	R-HSA-1296059	9.820060e-01	0.008	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.820060e-01	0.008	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	9.820060e-01	0.008	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.820060e-01	0.008	0	0
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.820060e-01	0.008	0	0
Hyaluronan degradation	R-HSA-2160916	9.820060e-01	0.008	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.820060e-01	0.008	0	0
Retinoid cycle disease events	R-HSA-2453864	9.820060e-01	0.008	0	0
Diseases of the neuronal system	R-HSA-9675143	9.820060e-01	0.008	0	0
Diseases associated with visual transduction	R-HSA-2474795	9.820060e-01	0.008	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.820060e-01	0.008	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.820918e-01	0.008	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.823042e-01	0.008	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	9.834391e-01	0.007	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.834391e-01	0.007	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	9.836729e-01	0.007	0	0
Formation of the cornified envelope	R-HSA-6809371	9.838206e-01	0.007	0	0
Attenuation phase	R-HSA-3371568	9.839789e-01	0.007	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.839789e-01	0.007	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.841953e-01	0.007	0	0
Sphingolipid catabolism	R-HSA-9845614	9.841953e-01	0.007	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	9.841953e-01	0.007	0	0
Viral Infection Pathways	R-HSA-9824446	9.856430e-01	0.006	1	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.856720e-01	0.006	0	0
Maturation of spike protein	R-HSA-9694548	9.856720e-01	0.006	0	0
Neutrophil degranulation	R-HSA-6798695	9.859573e-01	0.006	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.860548e-01	0.006	0	0
Cristae formation	R-HSA-8949613	9.861184e-01	0.006	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.861184e-01	0.006	0	0
Signaling by BMP	R-HSA-201451	9.861184e-01	0.006	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	9.861184e-01	0.006	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	9.861184e-01	0.006	0	0
Synthesis of PE	R-HSA-1483213	9.861184e-01	0.006	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.861184e-01	0.006	0	0
Maturation of hRSV A proteins	R-HSA-9828806	9.861184e-01	0.006	0	0
Interleukin-10 signaling	R-HSA-6783783	9.863928e-01	0.006	0	0
Integrin cell surface interactions	R-HSA-216083	9.863928e-01	0.006	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.866621e-01	0.006	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.870830e-01	0.006	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.871904e-01	0.006	0	0
Iron assimilation using enterobactin	R-HSA-9638334	9.878076e-01	0.005	0	0
Pyrimidine salvage	R-HSA-73614	9.878076e-01	0.005	0	0
Pyroptosis	R-HSA-5620971	9.878076e-01	0.005	0	0
Paracetamol ADME	R-HSA-9753281	9.879521e-01	0.005	0	0
Regulated Necrosis	R-HSA-5218859	9.885227e-01	0.005	0	0
Activation of GABAB receptors	R-HSA-991365	9.885516e-01	0.005	0	0
GABA B receptor activation	R-HSA-977444	9.885516e-01	0.005	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	9.885516e-01	0.005	0	0
Depyrimidination	R-HSA-73928	9.885516e-01	0.005	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.885516e-01	0.005	0	0
Late endosomal microautophagy	R-HSA-9615710	9.892913e-01	0.005	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.892913e-01	0.005	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	9.892913e-01	0.005	0	0
DNA methylation	R-HSA-5334118	9.892913e-01	0.005	0	0
Platelet calcium homeostasis	R-HSA-418360	9.892913e-01	0.005	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.892913e-01	0.005	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.899629e-01	0.004	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.905112e-01	0.004	0	0
DAP12 signaling	R-HSA-2424491	9.905945e-01	0.004	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	9.905945e-01	0.004	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.905945e-01	0.004	0	0
Eukaryotic Translation Elongation	R-HSA-156842	9.907836e-01	0.004	0	0
Surfactant metabolism	R-HSA-5683826	9.908637e-01	0.004	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.908637e-01	0.004	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.911412e-01	0.004	0	0
Ion channel transport	R-HSA-983712	9.911961e-01	0.004	0	0
Budding and maturation of HIV virion	R-HSA-162588	9.917392e-01	0.004	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.917392e-01	0.004	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.917392e-01	0.004	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.918207e-01	0.004	0	0
Peroxisomal protein import	R-HSA-9033241	9.920101e-01	0.003	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.927173e-01	0.003	0	0
DAG1 glycosylations	R-HSA-8931838	9.927446e-01	0.003	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	9.927446e-01	0.003	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.927446e-01	0.003	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.928812e-01	0.003	0	0
Leishmania infection	R-HSA-9658195	9.934752e-01	0.003	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.934752e-01	0.003	0	0
Recycling of bile acids and salts	R-HSA-159418	9.936278e-01	0.003	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.942011e-01	0.003	0	0
G alpha (q) signalling events	R-HSA-416476	9.942627e-01	0.002	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.944034e-01	0.002	0	0
Heme degradation	R-HSA-189483	9.944034e-01	0.002	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.948274e-01	0.002	0	0
Peptide chain elongation	R-HSA-156902	9.949688e-01	0.002	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.950847e-01	0.002	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.950847e-01	0.002	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.950847e-01	0.002	0	0
Cholesterol biosynthesis	R-HSA-191273	9.956338e-01	0.002	0	0
ABC transporter disorders	R-HSA-5619084	9.956338e-01	0.002	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.956831e-01	0.002	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.956831e-01	0.002	0	0
The phototransduction cascade	R-HSA-2514856	9.958875e-01	0.002	0	0
Immune System	R-HSA-168256	9.959713e-01	0.002	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.961578e-01	0.002	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.961942e-01	0.002	0	0
Cardiac conduction	R-HSA-5576891	9.963204e-01	0.002	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.964454e-01	0.002	0	0
Cleavage of the damaged purine	R-HSA-110331	9.966703e-01	0.001	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.966703e-01	0.001	0	0
NCAM1 interactions	R-HSA-419037	9.966703e-01	0.001	0	0
Collagen chain trimerization	R-HSA-8948216	9.966703e-01	0.001	0	0
Metabolism of folate and pterines	R-HSA-196757	9.966703e-01	0.001	0	0
tRNA processing in the mitochondrion	R-HSA-6785470	9.970757e-01	0.001	0	0
Depurination	R-HSA-73927	9.970757e-01	0.001	0	0
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.970757e-01	0.001	0	0
Elastic fibre formation	R-HSA-1566948	9.970757e-01	0.001	0	0
Post-translational protein modification	R-HSA-597592	9.973676e-01	0.001	0	0
Pentose phosphate pathway	R-HSA-71336	9.974318e-01	0.001	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.974318e-01	0.001	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.975543e-01	0.001	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.976253e-01	0.001	0	0
ECM proteoglycans	R-HSA-3000178	9.977432e-01	0.001	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.977446e-01	0.001	0	0
Eukaryotic Translation Termination	R-HSA-72764	9.978415e-01	0.001	0	0
Interferon gamma signaling	R-HSA-877300	9.980099e-01	0.001	0	0
G alpha (s) signalling events	R-HSA-418555	9.982953e-01	0.001	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.983812e-01	0.001	0	0
GABA receptor activation	R-HSA-977443	9.985505e-01	0.001	0	0
RAB geranylgeranylation	R-HSA-8873719	9.985505e-01	0.001	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.986119e-01	0.001	0	0
Defective pyroptosis	R-HSA-9710421	9.986584e-01	0.001	0	0
Selenocysteine synthesis	R-HSA-2408557	9.987891e-01	0.001	0	0
Translation of Structural Proteins	R-HSA-9694635	9.988186e-01	0.001	1	0
DAP12 interactions	R-HSA-2172127	9.988218e-01	0.001	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.988218e-01	0.001	0	0
Mitochondrial protein import	R-HSA-1268020	9.988528e-01	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.989231e-01	0.000	0	0
The canonical retinoid cycle in rods (twilight vision)	R-HSA-2453902	9.989654e-01	0.000	0	0
Viral mRNA Translation	R-HSA-192823	9.990035e-01	0.000	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.990498e-01	0.000	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.990914e-01	0.000	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.990914e-01	0.000	0	0
Hemostasis	R-HSA-109582	9.991129e-01	0.000	0	0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.992021e-01	0.000	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.992158e-01	0.000	0	0
Amyloid fiber formation	R-HSA-977225	9.992364e-01	0.000	0	0
Collagen formation	R-HSA-1474290	9.992929e-01	0.000	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.993847e-01	0.000	0	0
Azathioprine ADME	R-HSA-9748787	9.994597e-01	0.000	0	0
Protein localization	R-HSA-9609507	9.994999e-01	0.000	0	0
Complex IV assembly	R-HSA-9864848	9.995255e-01	0.000	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.995528e-01	0.000	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.996028e-01	0.000	0	0
Metal ion assimilation from the host	R-HSA-9638482	9.996028e-01	0.000	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.996341e-01	0.000	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.997218e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.997262e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.997472e-01	0.000	0	0
Dectin-2 family	R-HSA-5621480	9.997825e-01	0.000	0	0
Synthesis of PA	R-HSA-1483166	9.997825e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.997937e-01	0.000	0	0
rRNA processing	R-HSA-72312	9.998137e-01	0.000	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.998192e-01	0.000	1	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.998273e-01	0.000	0	0
Sialic acid metabolism	R-HSA-4085001	9.998323e-01	0.000	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.998323e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.998390e-01	0.000	0	0
Nucleotide salvage	R-HSA-8956321	9.998707e-01	0.000	0	0
Collagen degradation	R-HSA-1442490	9.998707e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.998787e-01	0.000	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.998829e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.998942e-01	0.000	0	0
Potassium Channels	R-HSA-1296071	9.998970e-01	0.000	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.999125e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.999139e-01	0.000	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.999147e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.999266e-01	0.000	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999347e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.999407e-01	0.000	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.999407e-01	0.000	0	0
Platelet degranulation	R-HSA-114608	9.999411e-01	0.000	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.999413e-01	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.999480e-01	0.000	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.999480e-01	0.000	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999503e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999522e-01	0.000	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	9.999595e-01	0.000	0	0
Glycosphingolipid catabolism	R-HSA-9840310	9.999599e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.999600e-01	0.000	0	0
Retinoid metabolism and transport	R-HSA-975634	9.999648e-01	0.000	0	0
Metabolism of cofactors	R-HSA-8978934	9.999648e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.999648e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999729e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.999729e-01	0.000	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.999802e-01	0.000	0	0
Disease	R-HSA-1643685	9.999810e-01	0.000	1	0
Selenoamino acid metabolism	R-HSA-2408522	9.999830e-01	0.000	0	0
Infectious disease	R-HSA-5663205	9.999881e-01	0.000	1	0
Keratinization	R-HSA-6805567	9.999891e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999904e-01	0.000	0	0
Translation	R-HSA-72766	9.999935e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999935e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999938e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.999938e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.999939e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999941e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999944e-01	0.000	0	0
Pyruvate metabolism	R-HSA-70268	9.999961e-01	0.000	0	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999966e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999979e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999981e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999985e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.999989e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.999990e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999991e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999991e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999993e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999993e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999998e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999999e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999999e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999999e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000	0	0
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000	0	0
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000e+00	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000	0	0
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	-0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000	0	0
Maturation of nucleoprotein	R-HSA-9683610	1.000000e+00	0.000	1	1
Translation of Structural Proteins	R-HSA-9683701	1.000000e+00	0.000	1	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Chromatin organization	R-HSA-4839726	7.233599e-08	7.141	0	0
Chromatin modifying enzymes	R-HSA-3247509	5.828466e-07	6.234	0	0
Signal Transduction	R-HSA-162582	9.431010e-07	6.025	1	0
Formation of axial mesoderm	R-HSA-9796292	5.969222e-06	5.224	0	0
TGFBR3 expression	R-HSA-9839394	2.373371e-05	4.625	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	2.314231e-05	4.636	0	0
Recycling pathway of L1	R-HSA-437239	1.877834e-05	4.726	0	0
PKMTs methylate histone lysines	R-HSA-3214841	1.712736e-05	4.766	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.968262e-05	4.527	0	0
Cell Cycle, Mitotic	R-HSA-69278	3.111775e-05	4.507	1	0
Cell Cycle	R-HSA-1640170	3.258418e-05	4.487	1	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.164778e-05	4.500	0	0
Signaling by Hippo	R-HSA-2028269	4.411767e-05	4.355	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	4.560481e-05	4.341	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.158082e-05	4.211	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	9.529720e-05	4.021	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	1.089977e-04	3.963	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.089977e-04	3.963	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.398022e-04	3.854	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	1.494650e-04	3.825	1	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.851394e-04	3.733	1	0
Signaling by LTK	R-HSA-9842663	2.051069e-04	3.688	0	0
Cellular Senescence	R-HSA-2559583	2.088644e-04	3.680	0	0
Apoptotic execution phase	R-HSA-75153	2.208800e-04	3.656	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.472655e-04	3.607	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.548595e-04	3.594	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.946534e-04	3.531	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.063342e-04	3.514	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	3.285388e-04	3.483	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	3.415212e-04	3.467	0	0
Gap junction trafficking and regulation	R-HSA-157858	3.666928e-04	3.436	0	0
Gene expression (Transcription)	R-HSA-74160	4.072433e-04	3.390	1	0
Clathrin-mediated endocytosis	R-HSA-8856828	4.461345e-04	3.351	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	4.633620e-04	3.334	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	4.751872e-04	3.323	0	0
Gap junction trafficking	R-HSA-190828	5.484358e-04	3.261	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.766347e-04	3.239	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	6.802368e-04	3.167	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	7.078011e-04	3.150	0	0
Signaling by NTRKs	R-HSA-166520	6.848607e-04	3.164	0	0
Signaling by ALK	R-HSA-201556	6.904644e-04	3.161	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	6.466510e-04	3.189	0	0
Gastrulation	R-HSA-9758941	7.441253e-04	3.128	0	0
M Phase	R-HSA-68886	7.889172e-04	3.103	0	0
Aggrephagy	R-HSA-9646399	8.201961e-04	3.086	0	0
Epigenetic regulation of gene expression	R-HSA-212165	9.767926e-04	3.010	1	0
Death Receptor Signaling	R-HSA-73887	1.112268e-03	2.954	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.124896e-03	2.949	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.241974e-03	2.906	0	0
Membrane Trafficking	R-HSA-199991	1.210139e-03	2.917	0	0
Formation of annular gap junctions	R-HSA-196025	1.397067e-03	2.855	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.524367e-03	2.817	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.494758e-03	2.825	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.718617e-03	2.765	0	0
MITF-M-dependent gene expression	R-HSA-9856651	1.725203e-03	2.763	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	1.760302e-03	2.754	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.855523e-03	2.732	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	1.776710e-03	2.750	0	0
Signaling by NOTCH	R-HSA-157118	1.870634e-03	2.728	0	0
Gap junction degradation	R-HSA-190873	2.034782e-03	2.691	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.360361e-03	2.627	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	2.329394e-03	2.633	1	0
SWI/SNF chromatin remodelers	R-HSA-9932451	2.253666e-03	2.647	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	2.253666e-03	2.647	0	0
Separation of Sister Chromatids	R-HSA-2467813	2.337741e-03	2.631	0	0
Mitotic Prometaphase	R-HSA-68877	2.309255e-03	2.637	0	0
Signaling by TGFBR3	R-HSA-9839373	2.409690e-03	2.618	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.592702e-03	2.586	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.486027e-03	2.604	0	0
Selective autophagy	R-HSA-9663891	2.486027e-03	2.604	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.057481e-03	2.515	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.746454e-03	2.561	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.989833e-03	2.524	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	3.031982e-03	2.518	0	0
Formation of definitive endoderm	R-HSA-9823730	2.673950e-03	2.573	0	0
NGF-stimulated transcription	R-HSA-9031628	3.163018e-03	2.500	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.968454e-03	2.527	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.968454e-03	2.527	0	0
Cell-extracellular matrix interactions	R-HSA-446353	2.968454e-03	2.527	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	3.181431e-03	2.497	0	0
Developmental Biology	R-HSA-1266738	3.052254e-03	2.515	1	0
Mitotic Anaphase	R-HSA-68882	2.863537e-03	2.543	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.039282e-03	2.517	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.679973e-03	2.572	0	0
NRAGE signals death through JNK	R-HSA-193648	3.051255e-03	2.516	0	0
Adipogenesis	R-HSA-9843745	3.228116e-03	2.491	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.324791e-03	2.478	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.909491e-03	2.408	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	3.890191e-03	2.410	0	0
L1CAM interactions	R-HSA-373760	3.885797e-03	2.411	0	0
Apoptosis	R-HSA-109581	4.053980e-03	2.392	0	0
Kinesins	R-HSA-983189	4.883657e-03	2.311	0	0
RNA Polymerase II Transcription	R-HSA-73857	4.997154e-03	2.301	1	0
Cell Cycle Checkpoints	R-HSA-69620	5.057653e-03	2.296	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	5.462163e-03	2.263	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	5.462163e-03	2.263	0	0
Activation of BH3-only proteins	R-HSA-114452	5.462163e-03	2.263	0	0
Cellular response to heat stress	R-HSA-3371556	5.723469e-03	2.242	1	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	5.914056e-03	2.228	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	6.392053e-03	2.194	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	6.392053e-03	2.194	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.914056e-03	2.228	0	0
Mitotic G2-G2/M phases	R-HSA-453274	6.063127e-03	2.217	0	0
Generic Transcription Pathway	R-HSA-212436	5.978580e-03	2.223	1	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.125782e-03	2.213	1	1
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	6.057629e-03	2.218	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.519333e-03	2.186	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	6.763828e-03	2.170	0	0
Repression of WNT target genes	R-HSA-4641265	6.778861e-03	2.169	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	7.381059e-03	2.132	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	7.437189e-03	2.129	0	0
Tie2 Signaling	R-HSA-210993	7.343936e-03	2.134	0	0
Macroautophagy	R-HSA-1632852	7.088222e-03	2.149	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	7.517170e-03	2.124	0	0
Signaling by ALK in cancer	R-HSA-9700206	7.517170e-03	2.124	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	7.343936e-03	2.134	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	7.453485e-03	2.128	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	7.948144e-03	2.100	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	8.606017e-03	2.065	0	0
Nuclear RNA decay	R-HSA-9930044	8.606017e-03	2.065	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	8.658038e-03	2.063	0	0
HCMV Early Events	R-HSA-9609690	9.530328e-03	2.021	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	9.021608e-03	2.045	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	9.907016e-03	2.004	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	9.182048e-03	2.037	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	9.020416e-03	2.045	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	9.975853e-03	2.001	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	9.975853e-03	2.001	0	0
Autophagy	R-HSA-9612973	1.019087e-02	1.992	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.074583e-02	1.969	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.074583e-02	1.969	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.080618e-02	1.966	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	1.086950e-02	1.964	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.086950e-02	1.964	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.086950e-02	1.964	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.207860e-02	1.918	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.111666e-02	1.954	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.207860e-02	1.918	0	0
Signaling by WNT	R-HSA-195721	1.177571e-02	1.929	1	0
Gap junction assembly	R-HSA-190861	1.134864e-02	1.945	0	0
Nuclear import of Rev protein	R-HSA-180746	1.134864e-02	1.945	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.278079e-02	1.893	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.280932e-02	1.892	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.293929e-02	1.888	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	1.343821e-02	1.872	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.343821e-02	1.872	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	1.345671e-02	1.871	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.362945e-02	1.866	0	0
Circadian clock	R-HSA-9909396	1.397016e-02	1.855	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.502297e-02	1.823	0	0
Signal attenuation	R-HSA-74749	1.572940e-02	1.803	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.638723e-02	1.785	0	0
RUNX2 regulates bone development	R-HSA-8941326	1.468724e-02	1.833	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.572940e-02	1.803	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.638723e-02	1.785	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	1.517207e-02	1.819	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.660062e-02	1.780	0	0
G2/M Transition	R-HSA-69275	1.746049e-02	1.758	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.755131e-02	1.756	0	0
Notch-HLH transcription pathway	R-HSA-350054	1.773960e-02	1.751	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.868733e-02	1.728	0	0
Signaling by NOTCH3	R-HSA-9012852	1.874014e-02	1.727	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.874014e-02	1.727	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.001444e-02	1.699	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.243081e-02	1.649	0	0
Amplification of signal from the kinetochores	R-HSA-141424	2.243081e-02	1.649	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	2.070501e-02	1.684	1	1
Signaling by EGFR	R-HSA-177929	2.060552e-02	1.686	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.060552e-02	1.686	0	0
Breakdown of the nuclear lamina	R-HSA-352238	2.055750e-02	1.687	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	2.070501e-02	1.684	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	2.095503e-02	1.679	0	0
Mitotic Prophase	R-HSA-68875	2.127541e-02	1.672	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	2.049340e-02	1.688	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.095503e-02	1.679	0	0
G0 and Early G1	R-HSA-1538133	2.270889e-02	1.644	0	0
Signaling by WNT in cancer	R-HSA-4791275	2.270889e-02	1.644	1	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.320554e-02	1.634	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	2.341111e-02	1.631	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.341111e-02	1.631	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.368149e-02	1.626	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	2.383520e-02	1.623	0	0
Cardiogenesis	R-HSA-9733709	2.564381e-02	1.591	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	2.564381e-02	1.591	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.594449e-02	1.586	0	0
G alpha (12/13) signalling events	R-HSA-416482	2.594449e-02	1.586	0	0
Post NMDA receptor activation events	R-HSA-438064	2.596183e-02	1.586	0	0
Chaperonin-mediated protein folding	R-HSA-390466	2.596183e-02	1.586	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.606260e-02	1.584	0	0
Programmed Cell Death	R-HSA-5357801	2.685708e-02	1.571	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.712553e-02	1.567	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.712553e-02	1.567	0	0
Polo-like kinase mediated events	R-HSA-156711	2.771269e-02	1.557	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.771269e-02	1.557	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.828578e-02	1.548	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	3.053397e-02	1.515	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	3.053397e-02	1.515	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.882775e-02	1.540	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.979447e-02	1.526	0	0
HATs acetylate histones	R-HSA-3214847	3.344883e-02	1.476	0	0
Cell junction organization	R-HSA-446728	3.274292e-02	1.485	0	0
tRNA processing in the nucleus	R-HSA-6784531	3.472534e-02	1.459	0	0
Heme signaling	R-HSA-9707616	3.472534e-02	1.459	0	0
Regulation of TP53 Expression	R-HSA-6804754	3.485746e-02	1.458	0	0
Cell-Cell communication	R-HSA-1500931	3.661542e-02	1.436	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	3.681552e-02	1.434	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	3.740354e-02	1.427	0	0
SOS-mediated signalling	R-HSA-112412	3.740354e-02	1.427	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.760653e-02	1.425	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.760653e-02	1.425	0	0
Protein folding	R-HSA-391251	3.899437e-02	1.409	0	0
Nervous system development	R-HSA-9675108	3.978677e-02	1.400	1	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.989497e-02	1.399	0	0
Cellular responses to stress	R-HSA-2262752	3.990220e-02	1.399	1	0
RET signaling	R-HSA-8853659	3.994859e-02	1.398	0	0
Signaling by TGFB family members	R-HSA-9006936	3.999249e-02	1.398	0	0
Regulation of endogenous retroelements	R-HSA-9842860	4.026007e-02	1.395	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.026007e-02	1.395	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.476949e-02	1.349	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.999821e-02	1.301	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	4.385549e-02	1.358	0	0
AURKA Activation by TPX2	R-HSA-8854518	4.722970e-02	1.326	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.419974e-02	1.355	0	0
HCMV Infection	R-HSA-9609646	4.202793e-02	1.376	0	0
CRMPs in Sema3A signaling	R-HSA-399956	4.378551e-02	1.359	1	1
Regulation of PD-L1(CD274) expression	R-HSA-9909648	4.351139e-02	1.361	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.246977e-02	1.372	0	0
Adherens junctions interactions	R-HSA-418990	4.641156e-02	1.333	0	0
Signaling by PDGFR in disease	R-HSA-9671555	4.911924e-02	1.309	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.246977e-02	1.372	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	4.725301e-02	1.326	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.727515e-02	1.325	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	4.641851e-02	1.333	0	0
TNF signaling	R-HSA-75893	4.727515e-02	1.325	0	0
Regulation of CDH1 Function	R-HSA-9764561	5.112472e-02	1.291	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	5.112472e-02	1.291	0	0
Erythropoietin activates RAS	R-HSA-9027284	5.144390e-02	1.289	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.144390e-02	1.289	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.144390e-02	1.289	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	5.294098e-02	1.276	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	5.326757e-02	1.274	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	5.449169e-02	1.264	0	0
Calcineurin activates NFAT	R-HSA-2025928	5.824113e-02	1.235	0	0
Unwinding of DNA	R-HSA-176974	5.824113e-02	1.235	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	5.865204e-02	1.232	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	5.865204e-02	1.232	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	5.967244e-02	1.224	0	0
Phosphorylation of the APC/C	R-HSA-176412	5.978519e-02	1.223	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.978519e-02	1.223	0	0
Signaling by MET	R-HSA-6806834	6.056668e-02	1.218	0	0
PKR-mediated signaling	R-HSA-9833482	6.056668e-02	1.218	0	0
DNA strand elongation	R-HSA-69190	6.153550e-02	1.211	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	6.245400e-02	1.204	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	7.008261e-02	1.154	0	0
Regulation of gap junction activity	R-HSA-191650	7.141141e-02	1.146	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	7.141141e-02	1.146	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	7.141141e-02	1.146	0	0
Pexophagy	R-HSA-9664873	7.031496e-02	1.153	0	0
Interleukin receptor SHC signaling	R-HSA-912526	6.265861e-02	1.203	0	0
Striated Muscle Contraction	R-HSA-390522	7.452076e-02	1.128	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	6.388365e-02	1.195	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	7.574106e-02	1.121	0	0
PI3K/AKT activation	R-HSA-198203	7.031496e-02	1.153	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	7.113118e-02	1.148	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	6.670251e-02	1.176	1	0
Switching of origins to a post-replicative state	R-HSA-69052	7.574106e-02	1.121	0	0
PTEN Regulation	R-HSA-6807070	6.818228e-02	1.166	0	0
MTOR signalling	R-HSA-165159	7.570718e-02	1.121	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.404587e-02	1.194	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	6.973078e-02	1.157	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.784721e-02	1.168	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	7.141141e-02	1.146	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	6.879876e-02	1.162	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	7.452076e-02	1.128	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	6.854684e-02	1.164	0	0
Vesicle-mediated transport	R-HSA-5653656	7.091407e-02	1.149	0	0
HDMs demethylate histones	R-HSA-3214842	7.809178e-02	1.107	0	0
Deubiquitination	R-HSA-5688426	7.546504e-02	1.122	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	6.784721e-02	1.168	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	7.570718e-02	1.121	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	6.879876e-02	1.162	0	0
Axon guidance	R-HSA-422475	7.182275e-02	1.144	1	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.341751e-02	1.134	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	7.846945e-02	1.105	0	0
Specification of primordial germ cells	R-HSA-9827857	7.846945e-02	1.105	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	7.907766e-02	1.102	0	0
G2/M DNA damage checkpoint	R-HSA-69473	8.053289e-02	1.094	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.071290e-02	1.093	0	0
Oncogenic MAPK signaling	R-HSA-6802957	8.158325e-02	1.088	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	8.341255e-02	1.079	0	0
Centrosome maturation	R-HSA-380287	8.550707e-02	1.068	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	8.650568e-02	1.063	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	8.853183e-02	1.053	0	0
Signalling to ERKs	R-HSA-187687	8.894457e-02	1.051	0	0
Signaling by NOTCH1	R-HSA-1980143	9.066370e-02	1.043	0	0
UCH proteinases	R-HSA-5689603	9.066370e-02	1.043	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	9.279080e-02	1.032	0	0
IRS activation	R-HSA-74713	9.279080e-02	1.032	0	0
G2 Phase	R-HSA-68911	9.279080e-02	1.032	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	9.279080e-02	1.032	0	0
Cellular responses to stimuli	R-HSA-8953897	9.377034e-02	1.028	1	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.157355e-01	0.937	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	1.157355e-01	0.937	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.157355e-01	0.937	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	1.157355e-01	0.937	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	1.157355e-01	0.937	0	0
Signaling by RNF43 mutants	R-HSA-5340588	1.157355e-01	0.937	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	9.746523e-02	1.011	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	9.746523e-02	1.011	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	9.746523e-02	1.011	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	9.746523e-02	1.011	1	1
RUNX3 regulates p14-ARF	R-HSA-8951936	1.123996e-01	0.949	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.123996e-01	0.949	1	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.123996e-01	0.949	1	1
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.123996e-01	0.949	1	1
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.123996e-01	0.949	1	1
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.123996e-01	0.949	1	1
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	9.970134e-02	1.001	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.112135e-01	0.954	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.232855e-01	0.909	0	0
G1/S-Specific Transcription	R-HSA-69205	9.668721e-02	1.015	0	0
Activation of the pre-replicative complex	R-HSA-68962	1.245797e-01	0.905	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	1.025061e-01	0.989	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.099165e-01	0.959	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.198578e-01	0.921	1	1
MET activates RAS signaling	R-HSA-8851805	1.123996e-01	0.949	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.121250e-01	0.950	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	9.537322e-02	1.021	1	1
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.025061e-01	0.989	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.025061e-01	0.989	0	0
COPI-mediated anterograde transport	R-HSA-6807878	9.561540e-02	1.019	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	1.132057e-01	0.946	0	0
Germ layer formation at gastrulation	R-HSA-9754189	9.970134e-02	1.001	0	0
Synthesis of DNA	R-HSA-69239	9.922055e-02	1.003	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.123996e-01	0.949	0	0
Signaling by RAS mutants	R-HSA-6802949	1.025061e-01	0.989	0	0
Activation of RAC1	R-HSA-428540	9.746523e-02	1.011	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	9.568033e-02	1.019	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.157355e-01	0.937	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.047765e-01	0.980	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.157355e-01	0.937	0	0
S Phase	R-HSA-69242	1.035118e-01	0.985	1	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.144238e-01	0.941	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	1.046835e-01	0.980	0	0
Co-inhibition by PD-1	R-HSA-389948	1.254303e-01	0.902	0	0
G2/M Checkpoints	R-HSA-69481	1.000791e-01	1.000	0	0
Cell-cell junction organization	R-HSA-421270	9.705068e-02	1.013	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	1.212110e-01	0.916	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.157355e-01	0.937	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	1.232855e-01	0.909	0	0
Interleukin-15 signaling	R-HSA-8983432	1.123996e-01	0.949	0	0
Regulation of TP53 Activity	R-HSA-5633007	1.046725e-01	0.980	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.157355e-01	0.937	0	0
snRNP Assembly	R-HSA-191859	1.195176e-01	0.923	0	0
Metabolism of non-coding RNA	R-HSA-194441	1.195176e-01	0.923	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	1.213550e-01	0.916	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.070131e-01	0.971	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	1.232855e-01	0.909	0	0
Inositol phosphate metabolism	R-HSA-1483249	1.240746e-01	0.906	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	1.025061e-01	0.989	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.265805e-01	0.898	0	0
Signaling by ERBB2	R-HSA-1227986	1.268068e-01	0.897	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.281389e-01	0.892	0	0
Frs2-mediated activation	R-HSA-170968	1.281389e-01	0.892	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.281389e-01	0.892	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.286412e-01	0.891	0	0
Interleukin-2 family signaling	R-HSA-451927	1.310509e-01	0.883	0	0
ESR-mediated signaling	R-HSA-8939211	1.315296e-01	0.881	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.334998e-01	0.875	0	0
MAP kinase activation	R-HSA-450294	1.343216e-01	0.872	0	0
EGFR downregulation	R-HSA-182971	1.351353e-01	0.869	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.352576e-01	0.869	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.352576e-01	0.869	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.352576e-01	0.869	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.352576e-01	0.869	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.352576e-01	0.869	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.352576e-01	0.869	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	1.358864e-01	0.867	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.358864e-01	0.867	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.383911e-01	0.859	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	1.958682e-01	0.708	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	1.958682e-01	0.708	0	0
Defective MMADHC causes MMAHCD	R-HSA-3359473	1.958682e-01	0.708	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	1.958682e-01	0.708	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	1.958682e-01	0.708	0	0
XAV939 stabilizes AXIN	R-HSA-5545619	1.958682e-01	0.708	0	0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	1.958682e-01	0.708	0	0
Defective VWF binding to collagen type I	R-HSA-9845622	1.958682e-01	0.708	0	0
Signaling by LTK in cancer	R-HSA-9842640	1.399216e-01	0.854	0	0
G2/M DNA replication checkpoint	R-HSA-69478	1.399216e-01	0.854	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	1.650627e-01	0.782	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	1.650627e-01	0.782	0	0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	1.650627e-01	0.782	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	1.650627e-01	0.782	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.650627e-01	0.782	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	1.909064e-01	0.719	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.909064e-01	0.719	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.446051e-01	0.840	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	1.446051e-01	0.840	0	0
Processive synthesis on the lagging strand	R-HSA-69183	1.617192e-01	0.791	0	0
SHC1 events in EGFR signaling	R-HSA-180336	1.617192e-01	0.791	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	1.617192e-01	0.791	1	1
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.975791e-01	0.704	0	0
MAP2K and MAPK activation	R-HSA-5674135	1.501478e-01	0.823	0	0
Signaling by RAF1 mutants	R-HSA-9656223	1.501478e-01	0.823	0	0
mRNA 3'-end processing	R-HSA-72187	1.509994e-01	0.821	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	2.082039e-01	0.682	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	1.709162e-01	0.767	0	0
RAF activation	R-HSA-5673000	1.809945e-01	0.742	0	0
DCC mediated attractive signaling	R-HSA-418885	1.617192e-01	0.791	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.650627e-01	0.782	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	1.909064e-01	0.719	0	0
FOXO-mediated transcription	R-HSA-9614085	1.826677e-01	0.738	0	0
Myogenesis	R-HSA-525793	2.056238e-01	0.687	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.460735e-01	0.835	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.975791e-01	0.704	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	1.445050e-01	0.840	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.445050e-01	0.840	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	1.446051e-01	0.840	0	0
Adrenoceptors	R-HSA-390696	1.909064e-01	0.719	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	1.975791e-01	0.704	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.601382e-01	0.796	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	1.536282e-01	0.814	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.056238e-01	0.687	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.056238e-01	0.687	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	1.690229e-01	0.772	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.404482e-01	0.852	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.765248e-01	0.753	0	0
PIP3 activates AKT signaling	R-HSA-1257604	1.642732e-01	0.784	1	0
p75NTR signals via NF-kB	R-HSA-193639	1.617192e-01	0.791	0	0
Prolonged ERK activation events	R-HSA-169893	1.794029e-01	0.746	0	0
Transport of connexins along the secretory pathway	R-HSA-190827	1.958682e-01	0.708	0	0
CREB phosphorylation	R-HSA-199920	1.399216e-01	0.854	0	0
Disorders of Developmental Biology	R-HSA-9675151	1.975791e-01	0.704	0	0
Deadenylation of mRNA	R-HSA-429947	1.765248e-01	0.753	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.573758e-01	0.803	0	0
Oncogene Induced Senescence	R-HSA-2559585	1.932695e-01	0.714	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.685298e-01	0.773	0	0
Intracellular signaling by second messengers	R-HSA-9006925	2.008961e-01	0.697	1	0
HIV Life Cycle	R-HSA-162587	1.435002e-01	0.843	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.425544e-01	0.846	0	0
Hedgehog 'off' state	R-HSA-5610787	1.899377e-01	0.721	1	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.420574e-01	0.848	0	0
mTORC1-mediated signalling	R-HSA-166208	1.489830e-01	0.827	0	0
Mitochondrial biogenesis	R-HSA-1592230	1.642411e-01	0.785	0	0
TBC/RABGAPs	R-HSA-8854214	1.704070e-01	0.769	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	1.462821e-01	0.835	0	0
MHC class II antigen presentation	R-HSA-2132295	2.032855e-01	0.692	0	0
Oligomerization of connexins into connexons	R-HSA-190704	1.958682e-01	0.708	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	1.446051e-01	0.840	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.399216e-01	0.854	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	1.968506e-01	0.706	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	1.650627e-01	0.782	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.650627e-01	0.782	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	1.794029e-01	0.746	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.573758e-01	0.803	0	0
ISG15 antiviral mechanism	R-HSA-1169408	1.554020e-01	0.809	0	0
Sensory processing of sound	R-HSA-9659379	1.871165e-01	0.728	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.625410e-01	0.789	1	1
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.882816e-01	0.725	0	0
Interleukin-7 signaling	R-HSA-1266695	1.908980e-01	0.719	0	0
Interleukin-17 signaling	R-HSA-448424	2.112018e-01	0.675	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.112018e-01	0.675	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	2.126083e-01	0.672	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.161726e-01	0.665	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.161726e-01	0.665	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	2.161726e-01	0.665	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	2.161726e-01	0.665	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.172311e-01	0.663	0	0
ALK mutants bind TKIs	R-HSA-9700645	2.172311e-01	0.663	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.172311e-01	0.663	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	2.172311e-01	0.663	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	2.172311e-01	0.663	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	2.172311e-01	0.663	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.172311e-01	0.663	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	2.172311e-01	0.663	0	0
Interleukin-1 processing	R-HSA-448706	2.172311e-01	0.663	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	2.184504e-01	0.661	0	0
G1/S Transition	R-HSA-69206	2.242378e-01	0.649	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	2.522340e-01	0.598	0	0
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	2.522340e-01	0.598	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	2.522340e-01	0.598	0	0
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	2.522340e-01	0.598	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	2.522340e-01	0.598	0	0
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	3.046519e-01	0.516	0	0
Defective MMACHC causes MAHCC	R-HSA-3359474	3.046519e-01	0.516	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.046519e-01	0.516	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.046519e-01	0.516	0	0
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	3.046519e-01	0.516	0	0
HCN channels	R-HSA-1296061	3.533983e-01	0.452	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	3.533983e-01	0.452	0	0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	3.533983e-01	0.452	0	0
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	3.533983e-01	0.452	0	0
Signaling by LRP5 mutants	R-HSA-5339717	3.533983e-01	0.452	0	0
Signaling by MAP2K mutants	R-HSA-9652169	3.533983e-01	0.452	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	3.533983e-01	0.452	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	3.533983e-01	0.452	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	2.438427e-01	0.613	0	0
Signaling by APC mutants	R-HSA-4839744	2.705717e-01	0.568	1	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.705717e-01	0.568	1	1
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.705717e-01	0.568	1	1
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.705717e-01	0.568	1	1
NOSIP mediated eNOS trafficking	R-HSA-203754	3.987302e-01	0.399	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	3.987302e-01	0.399	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	3.987302e-01	0.399	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.351107e-01	0.629	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	2.543236e-01	0.595	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.543236e-01	0.595	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	3.238141e-01	0.490	0	0
Leading Strand Synthesis	R-HSA-69109	3.238141e-01	0.490	0	0
Polymerase switching	R-HSA-69091	3.238141e-01	0.490	0	0
GRB2 events in EGFR signaling	R-HSA-179812	3.238141e-01	0.490	0	0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	4.408864e-01	0.356	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	4.408864e-01	0.356	0	0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	4.408864e-01	0.356	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	4.408864e-01	0.356	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	4.408864e-01	0.356	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	4.408864e-01	0.356	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	4.408864e-01	0.356	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	4.408864e-01	0.356	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	4.408864e-01	0.356	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	4.408864e-01	0.356	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	3.500912e-01	0.456	0	0
Lagging Strand Synthesis	R-HSA-69186	2.933106e-01	0.533	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	2.933106e-01	0.533	0	0
Signaling by Erythropoietin	R-HSA-9006335	2.515476e-01	0.599	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	3.129619e-01	0.505	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.129619e-01	0.505	0	0
Removal of the Flap Intermediate	R-HSA-69166	3.760096e-01	0.425	0	0
Retrograde neurotrophin signalling	R-HSA-177504	3.760096e-01	0.425	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.326427e-01	0.478	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.993306e-01	0.524	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.288728e-01	0.640	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.288728e-01	0.640	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.288728e-01	0.640	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.288728e-01	0.640	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.288728e-01	0.640	0	0
HSF1-dependent transactivation	R-HSA-3371571	2.609247e-01	0.583	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	3.718879e-01	0.430	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	4.264678e-01	0.370	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.853321e-01	0.545	1	1
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.480456e-01	0.458	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	2.578625e-01	0.589	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.106738e-01	0.387	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	3.561944e-01	0.448	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	3.704094e-01	0.431	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	4.297942e-01	0.367	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	4.297942e-01	0.367	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	4.297942e-01	0.367	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.486864e-01	0.348	0	0
HIV elongation arrest and recovery	R-HSA-167287	4.486864e-01	0.348	0	0
Formation of the Early Elongation Complex	R-HSA-113418	4.486864e-01	0.348	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	4.486864e-01	0.348	0	0
Attenuation phase	R-HSA-3371568	4.450279e-01	0.352	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	2.917516e-01	0.535	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	4.119182e-01	0.385	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	4.411537e-01	0.355	0	0
PPARA activates gene expression	R-HSA-1989781	3.795077e-01	0.421	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	4.452813e-01	0.351	0	0
mRNA Splicing	R-HSA-72172	3.660739e-01	0.436	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	2.954233e-01	0.530	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	4.106738e-01	0.387	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.933106e-01	0.533	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.933106e-01	0.533	0	0
Nucleotide Excision Repair	R-HSA-5696398	2.361325e-01	0.627	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	3.608493e-01	0.443	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	4.385641e-01	0.358	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	4.385641e-01	0.358	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	4.385641e-01	0.358	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.351107e-01	0.629	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.673160e-01	0.573	0	0
DAP12 signaling	R-HSA-2424491	2.673160e-01	0.573	0	0
Regulation of CDH11 function	R-HSA-9762292	2.438427e-01	0.613	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	2.972712e-01	0.527	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.450279e-01	0.352	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.718879e-01	0.430	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	3.533983e-01	0.452	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	3.987302e-01	0.399	0	0
NF-kB is activated and signals survival	R-HSA-209560	2.972712e-01	0.527	0	0
VLDLR internalisation and degradation	R-HSA-8866427	3.238141e-01	0.490	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	2.977177e-01	0.526	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.106738e-01	0.387	0	0
IGF1R signaling cascade	R-HSA-2428924	2.721001e-01	0.565	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.811307e-01	0.551	1	0
Formation of the posterior neural plate	R-HSA-9832991	2.705717e-01	0.568	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	3.987302e-01	0.399	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	3.987302e-01	0.399	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	2.972712e-01	0.527	0	0
MET promotes cell motility	R-HSA-8875878	4.130155e-01	0.384	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.832344e-01	0.548	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	3.500912e-01	0.456	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.635481e-01	0.439	0	0
Formation of paraxial mesoderm	R-HSA-9793380	3.863869e-01	0.413	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	2.972712e-01	0.527	0	0
Signalling to RAS	R-HSA-167044	2.933106e-01	0.533	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.326427e-01	0.478	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	4.264678e-01	0.370	0	0
HDACs deacetylate histones	R-HSA-3214815	3.102037e-01	0.508	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	2.357225e-01	0.628	0	0
Estrogen-dependent gene expression	R-HSA-9018519	2.287624e-01	0.641	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	2.858417e-01	0.544	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.972712e-01	0.527	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	4.014904e-01	0.396	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	4.014904e-01	0.396	0	0
DNA Replication Pre-Initiation	R-HSA-69002	3.850428e-01	0.414	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.543236e-01	0.595	0	0
Specification of the neural plate border	R-HSA-9834899	2.543236e-01	0.595	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	2.522340e-01	0.598	0	0
Signalling to ERK5	R-HSA-198765	2.522340e-01	0.598	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	3.046519e-01	0.516	0	0
MET interacts with TNS proteins	R-HSA-8875513	3.046519e-01	0.516	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	3.046519e-01	0.516	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	2.438427e-01	0.613	0	0
Reelin signalling pathway	R-HSA-8866376	3.987302e-01	0.399	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.972712e-01	0.527	0	0
Signaling by AXIN mutants	R-HSA-4839735	2.972712e-01	0.527	1	0
Signaling by AMER1 mutants	R-HSA-4839748	2.972712e-01	0.527	1	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.351107e-01	0.629	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	3.238141e-01	0.490	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	4.408864e-01	0.356	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.500912e-01	0.456	0	0
Intraflagellar transport	R-HSA-5620924	2.254560e-01	0.647	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	4.014904e-01	0.396	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	2.394603e-01	0.621	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.718879e-01	0.430	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	4.297942e-01	0.367	0	0
Cilium Assembly	R-HSA-5617833	2.660051e-01	0.575	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	4.450279e-01	0.352	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.754678e-01	0.425	0	0
Orc1 removal from chromatin	R-HSA-68949	4.411537e-01	0.355	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.420006e-01	0.466	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	3.613967e-01	0.442	0	0
RAF/MAP kinase cascade	R-HSA-5673001	3.212705e-01	0.493	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.302510e-01	0.638	0	0
PTK6 Activates STAT3	R-HSA-8849474	3.987302e-01	0.399	0	0
p75NTR recruits signalling complexes	R-HSA-209543	3.238141e-01	0.490	0	0
Differentiation of T cells	R-HSA-9945266	4.264678e-01	0.370	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	4.264678e-01	0.370	0	0
Rap1 signalling	R-HSA-392517	2.543236e-01	0.595	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	3.480456e-01	0.458	0	0
Neurexins and neuroligins	R-HSA-6794361	4.411537e-01	0.355	0	0
HIV Infection	R-HSA-162906	3.436091e-01	0.464	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	2.821993e-01	0.549	0	0
Negative regulation of MET activity	R-HSA-6807004	2.737446e-01	0.563	0	0
MAPK family signaling cascades	R-HSA-5683057	2.820175e-01	0.550	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	3.533983e-01	0.452	0	0
Formation of intermediate mesoderm	R-HSA-9761174	2.438427e-01	0.613	0	0
Disorders of Nervous System Development	R-HSA-9697154	3.238141e-01	0.490	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	3.238141e-01	0.490	0	0
Pervasive developmental disorders	R-HSA-9005895	3.238141e-01	0.490	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.297942e-01	0.367	0	0
Protein-protein interactions at synapses	R-HSA-6794362	2.393848e-01	0.621	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.338964e-01	0.631	0	0
Assembly of the pre-replicative complex	R-HSA-68867	3.355674e-01	0.474	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.961986e-01	0.402	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.961986e-01	0.402	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.961986e-01	0.402	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	4.119182e-01	0.385	0	0
Signaling by PTK6	R-HSA-8848021	4.119182e-01	0.385	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.515476e-01	0.599	0	0
Downstream signal transduction	R-HSA-186763	2.832551e-01	0.548	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.492044e-01	0.603	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	3.236556e-01	0.490	0	0
Neurodegenerative Diseases	R-HSA-8863678	3.718879e-01	0.430	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.718879e-01	0.430	0	0
Signaling by VEGF	R-HSA-194138	3.225278e-01	0.491	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.736121e-01	0.428	0	0
EPHB-mediated forward signaling	R-HSA-3928662	3.278478e-01	0.484	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.449674e-01	0.611	0	0
Semaphorin interactions	R-HSA-373755	2.610853e-01	0.583	1	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	2.438427e-01	0.613	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.351107e-01	0.629	0	0
Activation of ATR in response to replication stress	R-HSA-176187	3.155088e-01	0.501	0	0
Ca2+ pathway	R-HSA-4086398	2.399972e-01	0.620	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.297942e-01	0.367	0	0
Host Interactions of HIV factors	R-HSA-162909	4.203147e-01	0.376	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	4.297942e-01	0.367	0	0
Signaling by FGFR in disease	R-HSA-1226099	2.498798e-01	0.602	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	3.747563e-01	0.426	1	0
Formation of the anterior neural plate	R-HSA-9823739	4.014904e-01	0.396	0	0
The NLRP1 inflammasome	R-HSA-844455	3.046519e-01	0.516	0	0
Dopamine receptors	R-HSA-390651	3.533983e-01	0.452	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	3.987302e-01	0.399	0	0
Anchoring fibril formation	R-HSA-2214320	2.972712e-01	0.527	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	4.408864e-01	0.356	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	4.408864e-01	0.356	0	0
Regulation of KIT signaling	R-HSA-1433559	3.760096e-01	0.425	0	0
Smooth Muscle Contraction	R-HSA-445355	2.853321e-01	0.545	0	0
FLT3 signaling in disease	R-HSA-9682385	3.806218e-01	0.420	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	3.986170e-01	0.399	0	0
Interferon Signaling	R-HSA-913531	2.717454e-01	0.566	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	3.238141e-01	0.490	1	1
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.975018e-01	0.527	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	3.326427e-01	0.478	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	3.500912e-01	0.456	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.155088e-01	0.501	0	0
Signaling by NOTCH4	R-HSA-9013694	2.498798e-01	0.602	0	0
Gene Silencing by RNA	R-HSA-211000	3.659160e-01	0.437	0	0
Josephin domain DUBs	R-HSA-5689877	2.438427e-01	0.613	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	4.264678e-01	0.370	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	4.297942e-01	0.367	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	2.705717e-01	0.568	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	4.395456e-01	0.357	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.129619e-01	0.505	0	0
OAS antiviral response	R-HSA-8983711	3.238141e-01	0.490	0	0
PI Metabolism	R-HSA-1483255	4.368797e-01	0.360	0	0
Signaling by Leptin	R-HSA-2586552	2.438427e-01	0.613	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	3.563933e-01	0.448	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	3.867094e-01	0.413	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	3.326427e-01	0.478	0	0
Inflammasomes	R-HSA-622312	4.486864e-01	0.348	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	4.508870e-01	0.346	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	4.508870e-01	0.346	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	4.508870e-01	0.346	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	4.508870e-01	0.346	0	0
Fibronectin matrix formation	R-HSA-1566977	4.508870e-01	0.346	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	4.508870e-01	0.346	0	0
IRE1alpha activates chaperones	R-HSA-381070	4.517296e-01	0.345	0	0
Signaling by Hedgehog	R-HSA-5358351	4.521137e-01	0.345	1	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	4.522275e-01	0.345	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.551171e-01	0.342	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	4.551171e-01	0.342	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	4.560855e-01	0.341	1	0
EPH-Ephrin signaling	R-HSA-2682334	4.624861e-01	0.335	0	0
DNA Double Strand Break Response	R-HSA-5693606	4.625515e-01	0.335	0	0
Late endosomal microautophagy	R-HSA-9615710	4.673200e-01	0.330	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.673200e-01	0.330	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	4.673200e-01	0.330	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	4.727095e-01	0.325	0	0
DNA Replication	R-HSA-69306	4.727095e-01	0.325	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	4.747036e-01	0.324	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	4.747036e-01	0.324	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	4.747036e-01	0.324	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.747036e-01	0.324	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	4.764839e-01	0.322	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	4.772698e-01	0.321	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	4.781009e-01	0.320	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	4.800893e-01	0.319	0	0
Erythropoietin activates STAT5	R-HSA-9027283	4.800893e-01	0.319	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	4.800893e-01	0.319	0	0
Rab regulation of trafficking	R-HSA-9007101	4.808009e-01	0.318	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	4.827360e-01	0.316	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.856674e-01	0.314	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	4.856674e-01	0.314	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.874660e-01	0.312	0	0
Cytoprotection by HMOX1	R-HSA-9707564	4.912745e-01	0.309	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	4.953026e-01	0.305	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	4.963644e-01	0.304	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	4.963644e-01	0.304	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.978822e-01	0.303	0	0
GAB1 signalosome	R-HSA-180292	4.978822e-01	0.303	0	0
Ephrin signaling	R-HSA-3928664	4.978822e-01	0.303	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	4.978822e-01	0.303	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	4.978822e-01	0.303	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	4.978822e-01	0.303	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	4.978822e-01	0.303	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	4.978822e-01	0.303	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	4.978822e-01	0.303	0	0
Mismatch Repair	R-HSA-5358508	4.978822e-01	0.303	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	4.997855e-01	0.301	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	5.026028e-01	0.299	0	0
Budding and maturation of HIV virion	R-HSA-162588	5.037043e-01	0.298	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	5.071368e-01	0.295	0	0
Signaling by SCF-KIT	R-HSA-1433557	5.072318e-01	0.295	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	5.120003e-01	0.291	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	5.165456e-01	0.287	0	0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	5.165456e-01	0.287	0	0
Disinhibition of SNARE formation	R-HSA-114516	5.165456e-01	0.287	0	0
Recycling of eIF2:GDP	R-HSA-72731	5.165456e-01	0.287	0	0
PTK6 Expression	R-HSA-8849473	5.165456e-01	0.287	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	5.165456e-01	0.287	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	5.165456e-01	0.287	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.165456e-01	0.287	0	0
Regulation of PTEN localization	R-HSA-8948747	5.165456e-01	0.287	0	0
CHL1 interactions	R-HSA-447041	5.165456e-01	0.287	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	5.169816e-01	0.287	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	5.189913e-01	0.285	0	0
Crosslinking of collagen fibrils	R-HSA-2243919	5.203950e-01	0.284	0	0
Regulation of signaling by CBL	R-HSA-912631	5.203950e-01	0.284	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	5.203950e-01	0.284	0	0
The NLRP3 inflammasome	R-HSA-844456	5.203950e-01	0.284	0	0
DAP12 interactions	R-HSA-2172127	5.222991e-01	0.282	0	0
RMTs methylate histone arginines	R-HSA-3214858	5.222991e-01	0.282	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.241015e-01	0.281	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	5.267624e-01	0.278	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	5.267624e-01	0.278	0	0
Metabolism of RNA	R-HSA-8953854	5.283759e-01	0.277	0	0
Regulation of beta-cell development	R-HSA-186712	5.363800e-01	0.271	0	0
Somitogenesis	R-HSA-9824272	5.371429e-01	0.270	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	5.386257e-01	0.269	0	0
Integrin signaling	R-HSA-354192	5.387635e-01	0.269	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	5.387635e-01	0.269	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	5.396486e-01	0.268	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	5.422216e-01	0.266	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	5.422216e-01	0.266	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	5.422216e-01	0.266	0	0
Signaling by NODAL	R-HSA-1181150	5.422216e-01	0.266	0	0
Signal transduction by L1	R-HSA-445144	5.422216e-01	0.266	0	0
Nephrin family interactions	R-HSA-373753	5.422216e-01	0.266	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	5.424175e-01	0.266	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	5.479296e-01	0.261	0	0
Type I hemidesmosome assembly	R-HSA-446107	5.504477e-01	0.259	0	0
RSK activation	R-HSA-444257	5.504477e-01	0.259	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	5.504477e-01	0.259	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	5.504477e-01	0.259	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	5.504477e-01	0.259	0	0
MET receptor recycling	R-HSA-8875656	5.504477e-01	0.259	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	5.504477e-01	0.259	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	5.504477e-01	0.259	0	0
Co-stimulation by ICOS	R-HSA-9927354	5.504477e-01	0.259	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	5.504477e-01	0.259	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	5.504477e-01	0.259	0	0
Sodium/Proton exchangers	R-HSA-425986	5.504477e-01	0.259	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	5.517505e-01	0.258	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.556724e-01	0.255	0	0
Glycolysis	R-HSA-70171	5.565790e-01	0.254	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	5.633475e-01	0.249	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	5.633475e-01	0.249	0	0
ERK/MAPK targets	R-HSA-198753	5.633475e-01	0.249	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	5.712079e-01	0.243	0	0
Dual Incision in GG-NER	R-HSA-5696400	5.723584e-01	0.242	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.723584e-01	0.242	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	5.748743e-01	0.240	0	0
Signaling by PDGF	R-HSA-186797	5.748743e-01	0.240	0	0
Signaling by Interleukins	R-HSA-449147	5.761519e-01	0.239	0	0
Base Excision Repair	R-HSA-73884	5.791749e-01	0.237	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	5.802130e-01	0.236	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	5.802130e-01	0.236	0	0
Lipophagy	R-HSA-9613354	5.819743e-01	0.235	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	5.819743e-01	0.235	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	5.819743e-01	0.235	0	0
p75NTR regulates axonogenesis	R-HSA-193697	5.819743e-01	0.235	0	0
ARMS-mediated activation	R-HSA-170984	5.819743e-01	0.235	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	5.819743e-01	0.235	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	5.819743e-01	0.235	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	5.819743e-01	0.235	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	5.819743e-01	0.235	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	5.837636e-01	0.234	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	5.837636e-01	0.234	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	5.837636e-01	0.234	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	5.885149e-01	0.230	0	0
Leishmania phagocytosis	R-HSA-9664417	5.885149e-01	0.230	0	0
Parasite infection	R-HSA-9664407	5.885149e-01	0.230	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.885740e-01	0.230	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	5.885740e-01	0.230	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	5.885740e-01	0.230	0	0
RNA Polymerase I Transcription	R-HSA-73864	5.938828e-01	0.226	0	0
Insulin receptor signalling cascade	R-HSA-74751	5.995776e-01	0.222	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	6.034655e-01	0.219	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.034655e-01	0.219	0	0
Signaling by KIT in disease	R-HSA-9669938	6.034655e-01	0.219	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	6.043887e-01	0.219	0	0
GPVI-mediated activation cascade	R-HSA-114604	6.043887e-01	0.219	0	0
Regulation of TP53 Degradation	R-HSA-6804757	6.043887e-01	0.219	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.099265e-01	0.215	0	0
Cellular response to chemical stress	R-HSA-9711123	6.109939e-01	0.214	1	0
MAPK3 (ERK1) activation	R-HSA-110056	6.112917e-01	0.214	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	6.112917e-01	0.214	0	0
DNA replication initiation	R-HSA-68952	6.112917e-01	0.214	0	0
Folding of actin by CCT/TriC	R-HSA-390450	6.112917e-01	0.214	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	6.112917e-01	0.214	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	6.112917e-01	0.214	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	6.112917e-01	0.214	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	6.112917e-01	0.214	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	6.112917e-01	0.214	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	6.112917e-01	0.214	0	0
Cellular response to hypoxia	R-HSA-1234174	6.116205e-01	0.214	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	6.159086e-01	0.210	0	0
HCMV Late Events	R-HSA-9610379	6.182898e-01	0.209	0	0
Ovarian tumor domain proteases	R-HSA-5689896	6.197952e-01	0.208	0	0
Collagen chain trimerization	R-HSA-8948216	6.197952e-01	0.208	0	0
Homology Directed Repair	R-HSA-5693538	6.200685e-01	0.208	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	6.224531e-01	0.206	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	6.224531e-01	0.206	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	6.224531e-01	0.206	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	6.224531e-01	0.206	0	0
Formation of the ureteric bud	R-HSA-9830674	6.224531e-01	0.206	0	0
Growth hormone receptor signaling	R-HSA-982772	6.224531e-01	0.206	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.288653e-01	0.201	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.288653e-01	0.201	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	6.338842e-01	0.198	0	0
Ub-specific processing proteases	R-HSA-5689880	6.377832e-01	0.195	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	6.385546e-01	0.195	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	6.385546e-01	0.195	0	0
LGI-ADAM interactions	R-HSA-5682910	6.385546e-01	0.195	0	0
vRNA Synthesis	R-HSA-192814	6.385546e-01	0.195	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	6.385546e-01	0.195	0	0
Bicarbonate transporters	R-HSA-425381	6.385546e-01	0.195	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	6.385546e-01	0.195	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	6.385546e-01	0.195	0	0
Chylomicron assembly	R-HSA-8963888	6.385546e-01	0.195	0	0
PECAM1 interactions	R-HSA-210990	6.385546e-01	0.195	0	0
Interleukin-2 signaling	R-HSA-9020558	6.385546e-01	0.195	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.407295e-01	0.193	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	6.407295e-01	0.193	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	6.407295e-01	0.193	0	0
Chromosome Maintenance	R-HSA-73886	6.461273e-01	0.190	0	0
Transcription of the HIV genome	R-HSA-167172	6.464500e-01	0.189	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	6.465866e-01	0.189	0	0
DNA Repair	R-HSA-73894	6.481765e-01	0.188	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	6.493639e-01	0.188	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.493639e-01	0.188	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	6.493639e-01	0.188	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.545877e-01	0.184	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.545877e-01	0.184	0	0
Acyl chain remodelling of PS	R-HSA-1482801	6.583012e-01	0.182	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.583012e-01	0.182	0	0
Sema4D in semaphorin signaling	R-HSA-400685	6.583012e-01	0.182	0	0
Formation of the nephric duct	R-HSA-9830364	6.583012e-01	0.182	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	6.590561e-01	0.181	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.635203e-01	0.178	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.635203e-01	0.178	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	6.635203e-01	0.178	0	0
HIV Transcription Elongation	R-HSA-167169	6.635203e-01	0.178	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	6.635203e-01	0.178	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	6.639069e-01	0.178	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	6.639069e-01	0.178	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	6.678991e-01	0.175	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	6.685461e-01	0.175	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	6.685461e-01	0.175	0	0
MET activates PTK2 signaling	R-HSA-8874081	6.751770e-01	0.171	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	6.751770e-01	0.171	0	0
Potential therapeutics for SARS	R-HSA-9679191	6.752040e-01	0.171	0	0
FLT3 Signaling	R-HSA-9607240	6.772566e-01	0.169	0	0
Regulation of mitotic cell cycle	R-HSA-453276	6.792479e-01	0.168	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.792479e-01	0.168	0	0
Hedgehog 'on' state	R-HSA-5632684	6.792479e-01	0.168	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	6.873975e-01	0.163	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	6.874823e-01	0.163	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	6.874823e-01	0.163	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	6.874823e-01	0.163	0	0
Regulation of IFNG signaling	R-HSA-877312	6.874823e-01	0.163	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	6.874823e-01	0.163	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.874823e-01	0.163	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	6.905733e-01	0.161	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	6.905733e-01	0.161	0	0
HIV Transcription Initiation	R-HSA-167161	6.905733e-01	0.161	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	6.905733e-01	0.161	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.905733e-01	0.161	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.913682e-01	0.160	0	0
Signaling by BMP	R-HSA-201451	6.913682e-01	0.160	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	6.913682e-01	0.160	0	0
IRS-mediated signalling	R-HSA-112399	6.944217e-01	0.158	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	6.958217e-01	0.158	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	7.034724e-01	0.153	0	0
Interleukin-1 signaling	R-HSA-9020702	7.040227e-01	0.152	0	0
Muscle contraction	R-HSA-397014	7.092479e-01	0.149	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	7.094054e-01	0.149	0	0
Chylomicron remodeling	R-HSA-8963901	7.094054e-01	0.149	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	7.094054e-01	0.149	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	7.094054e-01	0.149	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	7.094054e-01	0.149	0	0
Signaling by ERBB4	R-HSA-1236394	7.099466e-01	0.149	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	7.108552e-01	0.148	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	7.159566e-01	0.145	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.159566e-01	0.145	0	0
Signaling by FGFR4	R-HSA-5654743	7.159566e-01	0.145	0	0
Extension of Telomeres	R-HSA-180786	7.165347e-01	0.145	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	7.165347e-01	0.145	0	0
Adaptive Immune System	R-HSA-1280218	7.188751e-01	0.143	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.197074e-01	0.143	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	7.217498e-01	0.142	0	0
mRNA Capping	R-HSA-72086	7.217498e-01	0.142	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	7.217498e-01	0.142	0	0
Regulation of gene expression in beta cells	R-HSA-210745	7.217498e-01	0.142	0	0
Netrin-1 signaling	R-HSA-373752	7.280297e-01	0.138	0	0
Amine ligand-binding receptors	R-HSA-375280	7.280297e-01	0.138	0	0
G1 Phase	R-HSA-69236	7.280297e-01	0.138	0	0
Cyclin D associated events in G1	R-HSA-69231	7.280297e-01	0.138	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.297918e-01	0.137	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	7.297918e-01	0.137	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	7.297918e-01	0.137	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	7.297918e-01	0.137	0	0
Physiological factors	R-HSA-5578768	7.297918e-01	0.137	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	7.297918e-01	0.137	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	7.297918e-01	0.137	0	0
Signal regulatory protein family interactions	R-HSA-391160	7.297918e-01	0.137	0	0
Glucose metabolism	R-HSA-70326	7.342715e-01	0.134	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	7.359707e-01	0.133	0	0
Interleukin-37 signaling	R-HSA-9008059	7.359707e-01	0.133	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	7.374468e-01	0.132	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.396964e-01	0.131	0	0
Nucleosome assembly	R-HSA-774815	7.396964e-01	0.131	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	7.396964e-01	0.131	0	0
DAG and IP3 signaling	R-HSA-1489509	7.396964e-01	0.131	0	0
Signaling by FGFR3	R-HSA-5654741	7.396964e-01	0.131	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.417168e-01	0.130	1	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.474563e-01	0.126	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	7.474563e-01	0.126	0	0
PCP/CE pathway	R-HSA-4086400	7.475728e-01	0.126	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	7.487491e-01	0.126	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	7.487491e-01	0.126	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	7.487491e-01	0.126	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	7.487491e-01	0.126	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	7.487491e-01	0.126	0	0
Signaling by Activin	R-HSA-1502540	7.487491e-01	0.126	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	7.487491e-01	0.126	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	7.487491e-01	0.126	0	0
p38MAPK events	R-HSA-171007	7.487491e-01	0.126	0	0
Protein methylation	R-HSA-8876725	7.487491e-01	0.126	0	0
Trafficking of AMPA receptors	R-HSA-399719	7.495671e-01	0.125	0	0
Cargo concentration in the ER	R-HSA-5694530	7.495671e-01	0.125	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	7.495671e-01	0.125	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	7.509622e-01	0.124	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.618332e-01	0.118	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.618332e-01	0.118	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	7.642699e-01	0.117	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.663775e-01	0.116	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	7.663775e-01	0.116	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	7.663775e-01	0.116	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	7.663775e-01	0.116	0	0
Negative regulation of FLT3	R-HSA-9706369	7.663775e-01	0.116	0	0
Activation of SMO	R-HSA-5635838	7.663775e-01	0.116	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	7.663775e-01	0.116	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	7.665948e-01	0.115	0	0
GPER1 signaling	R-HSA-9634597	7.723161e-01	0.112	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	7.733315e-01	0.112	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	7.749572e-01	0.111	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	7.749572e-01	0.111	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	7.749572e-01	0.111	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	7.749572e-01	0.111	0	0
Degradation of CDH1	R-HSA-9766229	7.824181e-01	0.107	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.824181e-01	0.107	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.824181e-01	0.107	0	0
DNA Damage Bypass	R-HSA-73893	7.824181e-01	0.107	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	7.827700e-01	0.106	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	7.827700e-01	0.106	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	7.827700e-01	0.106	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	7.827700e-01	0.106	0	0
Resolution of D-Loop Structures	R-HSA-5693537	7.867877e-01	0.104	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.867877e-01	0.104	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	7.867877e-01	0.104	0	0
Miscellaneous transport and binding events	R-HSA-5223345	7.867877e-01	0.104	0	0
PI3K Cascade	R-HSA-109704	7.921471e-01	0.101	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	7.931509e-01	0.101	0	0
Kidney development	R-HSA-9830369	7.931509e-01	0.101	0	0
Telomere Maintenance	R-HSA-157579	7.952697e-01	0.099	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.980132e-01	0.098	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	7.980132e-01	0.098	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	7.980132e-01	0.098	0	0
Glycogen storage diseases	R-HSA-3229121	7.980132e-01	0.098	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	7.980132e-01	0.098	0	0
Signaling by NOTCH2	R-HSA-1980145	7.980672e-01	0.098	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.980672e-01	0.098	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.980672e-01	0.098	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.980672e-01	0.098	0	0
Mitophagy	R-HSA-5205647	7.980672e-01	0.098	0	0
Hyaluronan metabolism	R-HSA-2142845	7.980672e-01	0.098	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	7.980672e-01	0.098	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.015109e-01	0.096	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	8.080300e-01	0.093	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	8.080300e-01	0.093	0	0
Regulation of Apoptosis	R-HSA-169911	8.088145e-01	0.092	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	8.088145e-01	0.092	0	0
PERK regulates gene expression	R-HSA-381042	8.088145e-01	0.092	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	8.105181e-01	0.091	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.105181e-01	0.091	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	8.105181e-01	0.091	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	8.117176e-01	0.091	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	8.121876e-01	0.090	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	8.121876e-01	0.090	0	0
Platelet sensitization by LDL	R-HSA-432142	8.121876e-01	0.090	0	0
Developmental Cell Lineages	R-HSA-9734767	8.154925e-01	0.089	0	0
COPII-mediated vesicle transport	R-HSA-204005	8.172239e-01	0.088	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.190488e-01	0.087	0	0
Calmodulin induced events	R-HSA-111933	8.190488e-01	0.087	0	0
CaM pathway	R-HSA-111997	8.190488e-01	0.087	0	0
Glycosphingolipid transport	R-HSA-9845576	8.190488e-01	0.087	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.190488e-01	0.087	0	0
RNA Polymerase III Transcription	R-HSA-74158	8.190488e-01	0.087	0	0
Meiotic synapsis	R-HSA-1221632	8.191772e-01	0.087	0	0
Hemostasis	R-HSA-109582	8.252626e-01	0.083	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	8.253681e-01	0.083	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	8.253681e-01	0.083	0	0
Pyrimidine biosynthesis	R-HSA-500753	8.253681e-01	0.083	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.253681e-01	0.083	0	0
Diseases of hemostasis	R-HSA-9671793	8.253681e-01	0.083	0	0
STING mediated induction of host immune responses	R-HSA-1834941	8.253681e-01	0.083	0	0
HDL remodeling	R-HSA-8964058	8.253681e-01	0.083	0	0
Degradation of AXIN	R-HSA-4641257	8.287892e-01	0.082	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	8.287892e-01	0.082	0	0
Reproduction	R-HSA-1474165	8.308575e-01	0.080	0	0
Diseases of programmed cell death	R-HSA-9645723	8.321426e-01	0.080	0	0
G alpha (z) signalling events	R-HSA-418597	8.354870e-01	0.078	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	8.376244e-01	0.077	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	8.376244e-01	0.077	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	8.376244e-01	0.077	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	8.376244e-01	0.077	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	8.376244e-01	0.077	0	0
Co-inhibition by CTLA4	R-HSA-389513	8.376244e-01	0.077	0	0
Glycogen synthesis	R-HSA-3322077	8.376244e-01	0.077	0	0
Pregnenolone biosynthesis	R-HSA-196108	8.376244e-01	0.077	0	0
Protein hydroxylation	R-HSA-9629569	8.376244e-01	0.077	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.380545e-01	0.077	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.380545e-01	0.077	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.380545e-01	0.077	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	8.401695e-01	0.076	0	0
SARS-CoV Infections	R-HSA-9679506	8.414878e-01	0.075	1	0
Signaling by FGFR1	R-HSA-5654736	8.431558e-01	0.074	0	0
Stabilization of p53	R-HSA-69541	8.468635e-01	0.072	0	0
Plasma lipoprotein clearance	R-HSA-8964043	8.468635e-01	0.072	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	8.490212e-01	0.071	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.490212e-01	0.071	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	8.490212e-01	0.071	0	0
Influenza Infection	R-HSA-168255	8.501239e-01	0.071	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	8.552345e-01	0.068	0	0
Generation of second messenger molecules	R-HSA-202433	8.552345e-01	0.068	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.552345e-01	0.068	0	0
Glycogen metabolism	R-HSA-8982491	8.552345e-01	0.068	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	8.552345e-01	0.068	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.552345e-01	0.068	0	0
Diseases of Immune System	R-HSA-5260271	8.552345e-01	0.068	0	0
Dual incision in TC-NER	R-HSA-6782135	8.575673e-01	0.067	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	8.596187e-01	0.066	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	8.596187e-01	0.066	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	8.596187e-01	0.066	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.596187e-01	0.066	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	8.596187e-01	0.066	0	0
Assembly Of The HIV Virion	R-HSA-175474	8.596187e-01	0.066	0	0
Signaling by Insulin receptor	R-HSA-74752	8.621381e-01	0.064	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.631856e-01	0.064	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.631856e-01	0.064	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.631856e-01	0.064	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.631856e-01	0.064	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.631856e-01	0.064	0	0
Transmission across Chemical Synapses	R-HSA-112315	8.658209e-01	0.063	0	0
Interleukin-1 family signaling	R-HSA-446652	8.680340e-01	0.061	0	0
FGFR2 alternative splicing	R-HSA-6803529	8.694729e-01	0.061	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	8.694729e-01	0.061	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.694729e-01	0.061	0	0
LDL clearance	R-HSA-8964038	8.694729e-01	0.061	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	8.759184e-01	0.058	0	0
TCR signaling	R-HSA-202403	8.767552e-01	0.057	0	0
PLC beta mediated events	R-HSA-112043	8.770079e-01	0.057	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.770079e-01	0.057	1	1
Collagen degradation	R-HSA-1442490	8.770079e-01	0.057	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.778792e-01	0.057	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	8.778983e-01	0.057	0	0
Depyrimidination	R-HSA-73928	8.778983e-01	0.057	0	0
Ca-dependent events	R-HSA-111996	8.778983e-01	0.057	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	8.786359e-01	0.056	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	8.786359e-01	0.056	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	8.786359e-01	0.056	0	0
Carnitine shuttle	R-HSA-200425	8.786359e-01	0.056	0	0
Syndecan interactions	R-HSA-3000170	8.786359e-01	0.056	0	0
tRNA processing	R-HSA-72306	8.787538e-01	0.056	0	0
Signaling by ROBO receptors	R-HSA-376176	8.810111e-01	0.055	0	0
Signaling by FGFR2	R-HSA-5654738	8.813096e-01	0.055	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	8.824787e-01	0.054	0	0
Defective pyroptosis	R-HSA-9710421	8.846940e-01	0.053	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.871562e-01	0.052	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.871562e-01	0.052	0	0
Plasma lipoprotein assembly	R-HSA-8963898	8.871562e-01	0.052	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	8.886242e-01	0.051	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.911379e-01	0.050	0	0
Surfactant metabolism	R-HSA-5683826	8.911379e-01	0.050	0	0
Interferon gamma signaling	R-HSA-877300	8.949734e-01	0.048	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	8.950788e-01	0.048	0	0
Long-term potentiation	R-HSA-9620244	8.950788e-01	0.048	0	0
Tight junction interactions	R-HSA-420029	8.950788e-01	0.048	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.950788e-01	0.048	0	0
Defects in cobalamin (B12) metabolism	R-HSA-3296469	8.950788e-01	0.048	0	0
Laminin interactions	R-HSA-3000157	8.950788e-01	0.048	0	0
Hyaluronan degradation	R-HSA-2160916	8.950788e-01	0.048	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.950788e-01	0.048	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.950788e-01	0.048	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.950788e-01	0.048	0	0
Toll-like Receptor Cascades	R-HSA-168898	8.950804e-01	0.048	0	0
SARS-CoV-1 Infection	R-HSA-9678108	8.964541e-01	0.047	1	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.972460e-01	0.047	0	0
Fanconi Anemia Pathway	R-HSA-6783310	8.972460e-01	0.047	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	8.972460e-01	0.047	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.024457e-01	0.045	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.024457e-01	0.045	0	0
Metalloprotease DUBs	R-HSA-5689901	9.024457e-01	0.045	0	0
Attachment of bacteria to epithelial cells	R-HSA-9638630	9.024457e-01	0.045	0	0
TRP channels	R-HSA-3295583	9.024457e-01	0.045	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.024457e-01	0.045	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.030335e-01	0.044	0	0
Diseases of DNA repair	R-HSA-9675135	9.030335e-01	0.044	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.030335e-01	0.044	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.030335e-01	0.044	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.038981e-01	0.044	0	0
Meiosis	R-HSA-1500620	9.053109e-01	0.043	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.060425e-01	0.043	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.085154e-01	0.042	0	0
G-protein mediated events	R-HSA-112040	9.089514e-01	0.041	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	9.092957e-01	0.041	0	0
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.092957e-01	0.041	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	9.092957e-01	0.041	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	9.092957e-01	0.041	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.092957e-01	0.041	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.092957e-01	0.041	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.134779e-01	0.039	0	0
Co-stimulation by CD28	R-HSA-389356	9.137060e-01	0.039	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.137060e-01	0.039	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.156650e-01	0.038	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.156650e-01	0.038	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.156650e-01	0.038	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.156650e-01	0.038	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.156650e-01	0.038	0	0
Neuronal System	R-HSA-112316	9.185453e-01	0.037	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.186192e-01	0.037	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.197388e-01	0.036	0	0
SLC transporter disorders	R-HSA-5619102	9.199901e-01	0.036	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.215875e-01	0.035	0	0
DNA methylation	R-HSA-5334118	9.215875e-01	0.035	0	0
Platelet calcium homeostasis	R-HSA-418360	9.215875e-01	0.035	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.215875e-01	0.035	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.215875e-01	0.035	0	0
RSV-host interactions	R-HSA-9833110	9.231331e-01	0.035	0	0
Regulation of RAS by GAPs	R-HSA-5658442	9.232684e-01	0.035	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	9.232684e-01	0.035	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.258376e-01	0.033	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.258550e-01	0.033	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.270944e-01	0.033	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.270944e-01	0.033	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	9.276663e-01	0.033	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.283011e-01	0.032	0	0
Neurotransmitter release cycle	R-HSA-112310	9.283617e-01	0.032	0	0
Downstream TCR signaling	R-HSA-202424	9.283617e-01	0.032	0	0
SARS-CoV-2 Infection	R-HSA-9694516	9.288563e-01	0.032	1	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.297700e-01	0.032	0	0
Viral Infection Pathways	R-HSA-9824446	9.315648e-01	0.031	1	0
RNA Polymerase I Promoter Escape	R-HSA-73772	9.318253e-01	0.031	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.318253e-01	0.031	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.318253e-01	0.031	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.322149e-01	0.030	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.322149e-01	0.030	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.322149e-01	0.030	0	0
Stimuli-sensing channels	R-HSA-2672351	9.354705e-01	0.029	0	0
Amino acids regulate mTORC1	R-HSA-9639288	9.357573e-01	0.029	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	9.357573e-01	0.029	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.369760e-01	0.028	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.378744e-01	0.028	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.394736e-01	0.027	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	9.397020e-01	0.027	0	0
Protein ubiquitination	R-HSA-8852135	9.398347e-01	0.027	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.406774e-01	0.027	0	0
G-protein beta:gamma signalling	R-HSA-397795	9.414029e-01	0.026	0	0
Recycling of bile acids and salts	R-HSA-159418	9.414029e-01	0.026	0	0
Regulation of necroptotic cell death	R-HSA-5675482	9.414029e-01	0.026	0	0
Collagen formation	R-HSA-1474290	9.435626e-01	0.025	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.435626e-01	0.025	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.455192e-01	0.024	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.455192e-01	0.024	0	0
Vpu mediated degradation of CD4	R-HSA-180534	9.455192e-01	0.024	0	0
Ion homeostasis	R-HSA-5578775	9.463023e-01	0.024	0	0
eNOS activation	R-HSA-203615	9.493465e-01	0.023	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.493465e-01	0.023	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.493465e-01	0.023	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	9.493465e-01	0.023	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.493465e-01	0.023	1	1
NPAS4 regulates expression of target genes	R-HSA-9768919	9.493465e-01	0.023	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.513602e-01	0.022	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	9.523929e-01	0.021	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.529052e-01	0.021	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.529052e-01	0.021	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.529052e-01	0.021	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.529052e-01	0.021	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.538758e-01	0.021	0	0
Signaling by FGFR	R-HSA-190236	9.557618e-01	0.020	0	0
HSF1 activation	R-HSA-3371511	9.562140e-01	0.019	0	0
PRC2 methylates histones and DNA	R-HSA-212300	9.562140e-01	0.019	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.562140e-01	0.019	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.562140e-01	0.019	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.578200e-01	0.019	0	0
Degradation of DVL	R-HSA-4641258	9.592906e-01	0.018	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.592906e-01	0.018	1	1
NCAM1 interactions	R-HSA-419037	9.592906e-01	0.018	0	0
Metabolism of folate and pterines	R-HSA-196757	9.592906e-01	0.018	0	0
Biofilm formation	R-HSA-9931953	9.621511e-01	0.017	0	0
Purine salvage	R-HSA-74217	9.621511e-01	0.017	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.621511e-01	0.017	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.648108e-01	0.016	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.648108e-01	0.016	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.648108e-01	0.016	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.648633e-01	0.016	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.666761e-01	0.015	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.689151e-01	0.014	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.695831e-01	0.013	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.695831e-01	0.013	0	0
Maturation of spike protein	R-HSA-9694548	9.695831e-01	0.013	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.703576e-01	0.013	0	0
Cellular response to starvation	R-HSA-9711097	9.713338e-01	0.013	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.716249e-01	0.013	0	0
Leishmania infection	R-HSA-9658195	9.716249e-01	0.013	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.717209e-01	0.012	0	0
Intra-Golgi traffic	R-HSA-6811438	9.717209e-01	0.012	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.717209e-01	0.012	1	1
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.717209e-01	0.012	1	1
Scavenging by Class A Receptors	R-HSA-3000480	9.717209e-01	0.012	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	9.737086e-01	0.012	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.755567e-01	0.011	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.772750e-01	0.010	0	0
Proteasome assembly	R-HSA-9907900	9.772750e-01	0.010	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.772750e-01	0.010	0	0
ECM proteoglycans	R-HSA-3000178	9.785453e-01	0.009	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.788726e-01	0.009	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.788726e-01	0.009	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.788726e-01	0.009	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.792594e-01	0.009	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.797637e-01	0.009	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.803580e-01	0.009	0	0
Neddylation	R-HSA-8951664	9.806778e-01	0.008	0	0
Synthesis of PC	R-HSA-1483191	9.817390e-01	0.008	0	0
Metal ion SLC transporters	R-HSA-425410	9.830230e-01	0.007	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.838502e-01	0.007	0	0
Interleukin-12 signaling	R-HSA-9020591	9.843007e-01	0.007	0	0
Regulation of insulin secretion	R-HSA-422356	9.855847e-01	0.006	0	0
Integrin cell surface interactions	R-HSA-216083	9.861553e-01	0.006	0	0
Cholesterol biosynthesis	R-HSA-191273	9.861553e-01	0.006	0	0
Integration of energy metabolism	R-HSA-163685	9.863583e-01	0.006	0	0
Meiotic recombination	R-HSA-912446	9.863587e-01	0.006	0	0
Complex IV assembly	R-HSA-9864848	9.863587e-01	0.006	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.863587e-01	0.006	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.882101e-01	0.005	0	0
Translation initiation complex formation	R-HSA-72649	9.890394e-01	0.005	0	0
Opioid Signalling	R-HSA-111885	9.897801e-01	0.004	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.898191e-01	0.004	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.899073e-01	0.004	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	9.905272e-01	0.004	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.905272e-01	0.004	0	0
Phospholipid metabolism	R-HSA-1483257	9.908546e-01	0.004	0	0
Extracellular matrix organization	R-HSA-1474244	9.908589e-01	0.004	0	0
Synthesis of PA	R-HSA-1483166	9.911936e-01	0.004	0	0
Platelet homeostasis	R-HSA-418346	9.914091e-01	0.004	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.918941e-01	0.004	0	0
Peroxisomal protein import	R-HSA-9033241	9.923892e-01	0.003	0	0
Interleukin-12 family signaling	R-HSA-447115	9.926600e-01	0.003	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.928318e-01	0.003	0	0
Metabolism of polyamines	R-HSA-351202	9.929248e-01	0.003	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.929248e-01	0.003	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.932817e-01	0.003	0	0
Endogenous sterols	R-HSA-211976	9.934226e-01	0.003	0	0
Nucleotide salvage	R-HSA-8956321	9.934226e-01	0.003	0	0
ER-Phagosome pathway	R-HSA-1236974	9.935420e-01	0.003	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.936041e-01	0.003	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.942399e-01	0.003	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.945479e-01	0.002	0	0
Cap-dependent Translation Initiation	R-HSA-72737	9.957534e-01	0.002	0	0
Eukaryotic Translation Initiation	R-HSA-72613	9.957534e-01	0.002	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.957550e-01	0.002	0	0
Metabolism of steroid hormones	R-HSA-196071	9.957550e-01	0.002	0	0
Immune System	R-HSA-168256	9.957714e-01	0.002	0	0
Peptide hormone metabolism	R-HSA-2980736	9.959982e-01	0.002	0	0
Regulated Necrosis	R-HSA-5218859	9.960539e-01	0.002	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.961426e-01	0.002	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.965900e-01	0.001	0	0
G alpha (q) signalling events	R-HSA-416476	9.967665e-01	0.001	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.968245e-01	0.001	0	0
Retinoid metabolism and transport	R-HSA-975634	9.968301e-01	0.001	0	0
Metabolism of cofactors	R-HSA-8978934	9.968301e-01	0.001	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.972117e-01	0.001	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.972608e-01	0.001	0	0
Formation of the cornified envelope	R-HSA-6809371	9.973664e-01	0.001	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.974537e-01	0.001	0	0
Neutrophil degranulation	R-HSA-6798695	9.976399e-01	0.001	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.977334e-01	0.001	0	0
Platelet degranulation	R-HSA-114608	9.979305e-01	0.001	0	0
Translation of Structural Proteins	R-HSA-9694635	9.979547e-01	0.001	1	0
G alpha (s) signalling events	R-HSA-418555	9.980035e-01	0.001	0	0
ABC transporter disorders	R-HSA-5619084	9.980988e-01	0.001	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.980988e-01	0.001	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.984519e-01	0.001	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.984519e-01	0.001	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.984519e-01	0.001	0	0
Cardiac conduction	R-HSA-5576891	9.984719e-01	0.001	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.984730e-01	0.001	0	0
Amyloid fiber formation	R-HSA-977225	9.984730e-01	0.001	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.988101e-01	0.001	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.988101e-01	0.001	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.990150e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.990238e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.991447e-01	0.000	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.991447e-01	0.000	0	0
Peptide chain elongation	R-HSA-156902	9.991490e-01	0.000	0	0
rRNA processing	R-HSA-72312	9.992129e-01	0.000	0	0
Ion channel transport	R-HSA-983712	9.992550e-01	0.000	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.993166e-01	0.000	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.993648e-01	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.993918e-01	0.000	0	0
Post-translational protein modification	R-HSA-597592	9.994023e-01	0.000	0	0
Eukaryotic Translation Elongation	R-HSA-156842	9.994095e-01	0.000	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.994095e-01	0.000	1	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.995259e-01	0.000	0	0
Eukaryotic Translation Termination	R-HSA-72764	9.995593e-01	0.000	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	9.995593e-01	0.000	0	0
Potassium Channels	R-HSA-1296071	9.995904e-01	0.000	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.996303e-01	0.000	0	0
Protein localization	R-HSA-9609507	9.996527e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.996711e-01	0.000	0	0
Selenocysteine synthesis	R-HSA-2408557	9.997159e-01	0.000	0	0
Viral mRNA Translation	R-HSA-192823	9.997545e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.998017e-01	0.000	0	0
Ribosome-associated quality control	R-HSA-9948299	9.998494e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.998633e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.998730e-01	0.000	0	0
Infectious disease	R-HSA-5663205	9.998746e-01	0.000	1	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999224e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999544e-01	0.000	0	0
Disease	R-HSA-1643685	9.999717e-01	0.000	1	0
Nucleotide catabolism	R-HSA-8956319	9.999727e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999799e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.999849e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999853e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999897e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999942e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999953e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	9.999960e-01	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999969e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999977e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999979e-01	0.000	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.999983e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999986e-01	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.999987e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.999992e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999992e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999994e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.999995e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999999e-01	0.000	0	0
Infection with Enterobacteria	R-HSA-9640148	9.999999e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Translation	R-HSA-72766	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
Maturation of nucleoprotein	R-HSA-9683610	1.000000e+00	0.000	1	1
Translation of Structural Proteins	R-HSA-9683701	1.000000e+00	0.000	1	0
Maturation of nucleoprotein	R-HSA-9694631	1.000000e+00	0.000	1	1