HIPK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O00115 S70 Sugiyama DNASE2 DNASE2A DNL2 QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00257 T497 GPS6|EPSD|PSP CBX4 CVKTRSEAGEPPSSLQVKPEtPASAAVAVAAAAAPTTTAEK
O15297 S54 SIGNOR|PSP PPM1D WIP1 tAEEKPsPRRSLSQPLPPRPsPAALPGGEVSGKGPAVAARE
O15297 S85 SIGNOR|EPSD|PSP PPM1D WIP1 GKGPAVAAREARDPLPDAGAsPAPSRCCRRRSSVAFFAVCD
O15379 S374 SIGNOR|PSP HDAC3 YLDQIRQTIFENLKMLNHAPsVQIHDVPADLLTYDRTDEAD
O43255 S28 EPSD|PSP SIAH2 GPsANKPCsKQPPPQPQHtPsPAAPPAAATISAAGPGSSAV
O43255 S68 PSP SIAH2 VPAAAAVISGPGGGGGAGPVsPQHHELTSLFECPVCFDYVL
O43255 T119 PSP SIAH2 LVCNQCRQKLSCCPTCRGALtPSIRNLAMEKVASAVLFPCK
O43255 T26 PSP SIAH2 stGPsANKPCsKQPPPQPQHtPsPAAPPAAATISAAGPGSS
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75128 T1228 Sugiyama COBL KIAA0633 PPPPPPSQALSAPRTAsRFstGtLSNTADARQALMDAIRSG
O94842 S178 Sugiyama TOX4 C14orf92 KIAA0737 GGGTILPPAQSPEDRLsttPsPtssLHEDGVEDFRRQLPSQ
O94842 T176 Sugiyama TOX4 C14orf92 KIAA0737 SLGGGTILPPAQSPEDRLsttPsPtssLHEDGVEDFRRQLP
P04637 S46 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP TP53 P53 LPENNVLsPLPsQAMDDLMLsPDDIEQWFtEDPGPDEAPRM
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 S263 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GMDVAASEFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsF
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814 S739 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07814 T737 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 EKTKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRV
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P10809 S70 Sugiyama HSPD1 HSP60 AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142 T37 Sugiyama HSPA8 HSC70 HSP73 HSPA10 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142 T38 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P16220 S257 SIGNOR|PSP CREB1 TYQIRTAPTSTIAPGVVMAssPALPTQPAEEAARKREVRLM
P17096 S36 GPS6|SIGNOR|EPSD|PSP HMGA1 HMGIY QEKDGTEKRGRGRPRKQPPVsPGtALVGsQKEPsEVPtPKR
P17096 T53 GPS6|SIGNOR|EPSD|PSP HMGA1 HMGIY PPVsPGtALVGsQKEPsEVPtPKRPRGRPKGsKNKGAAKTR
P17096 T78 GPS6|EPSD|PSP HMGA1 HMGIY RGRPKGsKNKGAAKTRKTTTtPGRKPRGRPKKLEKEEEEGI
P17676 S76 PSP CEBPB TCF5 PP9092 PRPPAGELGsIGDHERAIDFsPyLEPLGAPQAPAPATATDT
P17676 T235 EPSD|PSP CEBPB TCF5 PP9092 AVPsGssGsLstsssssPPGtPsPADAKAPPTACyAGAAPA
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18615 Y133 Sugiyama NELFE RD RDBP sIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEA
P18846 S198 GPS6|EPSD ATF1 TYQIRttPsAtsLPQtVVMtsPVTLTSQTTKTDDPQLKREI
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S259 Sugiyama HNRNPA2B1 HNRPA2B1 GFGDGyNGyGGGPGGGNFGGsPGyGGGRGGYGGGGPGYGNQ
P26367 T281 SIGNOR|EPSD PAX6 AN2 RRAKWRREEKLRNQRRQASNtPSHIPISSSFSTSVYQPIPQ
P26367 T304 SIGNOR|EPSD PAX6 AN2 HIPISSSFSTSVYQPIPQPTtPVSSFTSGSMLGRTDTALTN
P26367 T373 SIGNOR|EPSD PAX6 AN2 SYSCMLPTSPSVNGRSYDTYtPPHMQTHMNSQPMGTSGTTS
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27824 S362 Sugiyama CANX WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P29590 S36 EPSD|PSP PML MYL PP8675 RNF71 TRIM19 ARPQEPtMPPPEtPsEGRQPsPsPsPtERAPAsEEEFQFLR
P29590 S38 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP PML MYL PP8675 RNF71 TRIM19 PQEPtMPPPEtPsEGRQPsPsPsPtERAPAsEEEFQFLRCQ
P29590 S8 GPS6|SIGNOR|EPSD|PSP PML MYL PP8675 RNF71 TRIM19 _____________MEPAPARsPRPQQDPARPQEPtMPPPEt
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931 T39 Sugiyama HSPA1L CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34931 T40 Sugiyama HSPA1L VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P35222 S33 GPS6|EPSD CTNNB1 CTNNB OK/SW-cl.35 PRO2286 AMEPDRKAAVsHWQQQsyLDsGIHsGATtTAPsLsGKGNPE
P35222 S37 GPS6 CTNNB1 CTNNB OK/SW-cl.35 PRO2286 DRKAAVsHWQQQsyLDsGIHsGATtTAPsLsGKGNPEEEDV
P35269 T389 Sugiyama GTF2F1 RAP74 PPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAASKLE
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T86 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38646 T87 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P42166 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42166 T74 Sugiyama TMPO LAP2 PAGTNsKGPPDFssDEEREPtPVLGsGAAAAGRSRAAVGRK
P42167 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P42167 T74 Sugiyama TMPO LAP2 PAGTNSKGPPDFssDEEREPtPVLGsGAAAAGRSRAAVGRK
P46013 S1131 Sugiyama MKI67 tPGPsEEsMtDEKTTKIACKsPPPEsVDtPtstKQWPKRSL
P46013 S2105 Sugiyama MKI67 tPDHTEESttDDKTTKIACKsPPPEsMDtPTstRRRPKtPL
P46527 S10 SIGNOR|EPSD|PSP CDKN1B KIP1 p27 ___________MSNVRVSNGsPsLERMDARQAEHPKPSACR
P46531 T2511 EPSD|PSP NOTCH1 TAN1 SSPVDNTPSHQLQVPEHPFLtPsPEsPDQWssssPHSNVSD
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P49023 S303 Sugiyama PXN QRADGERCWAAGWPRDGGRssPGGQDEGGFMAQGKtGsssP
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P51608 S216 EPSD|PSP MECP2 TTRPKAATSEGVQVKRVLEKsPGKLLVKMPFQtsPGGKAEG
P51608 S80 SIGNOR|EPSD|PSP MECP2 GKAETsEGsGsAPAVPEAsAsPKQRRSIIRDRGPMYDDPTL
P52945 S268 GPS6|SIGNOR|EPSD PDX1 IPF1 STF1 VPPAAPVAAREGRLPPGLSAsPQPssVAPRRPQEPR_____
P54652 T38 Sugiyama HSPA2 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P54652 T39 Sugiyama HSPA2 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P56545 S428 EPSD|PSP CTBP2 PGGIPVTHNLPTVAHPSQAPsPNQPTKHGDNREHPNEQ___
P57682 S101 EPSD|PSP KLF3 BKLF sLKFPSSHRRAsPGLSMPsssPPIKKysPPsPGVQPFGVPL
P57682 S108 EPSD|PSP KLF3 BKLF HRRAsPGLSMPsssPPIKKysPPsPGVQPFGVPLSMPPVMA
P57682 S111 EPSD|PSP KLF3 BKLF AsPGLSMPsssPPIKKysPPsPGVQPFGVPLSMPPVMAAAL
P57682 S216 EPSD|PSP KLF3 BKLF KIKIEPGIEPQRTDYYPEEMsPPLMNsVsPPQALLQENHPS
P57682 S224 EPSD|PSP KLF3 BKLF EPQRTDYYPEEMsPPLMNsVsPPQALLQENHPSVIVQPGKR
P57682 S250 EPSD|PSP KLF3 BKLF LQENHPSVIVQPGKRPLPVEsPDTQRKRRIHRCDYDGCNKV
P57682 S71 EPSD|PSP KLF3 BKLF EGLSHGIQMEPVDLTVNKRssPPsAGNsPssLKFPSSHRRA
P57682 S78 EPSD|PSP KLF3 BKLF QMEPVDLTVNKRssPPsAGNsPssLKFPSSHRRAsPGLSMP
P57682 S92 EPSD|PSP KLF3 BKLF PPsAGNsPssLKFPSSHRRAsPGLSMPsssPPIKKysPPsP
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q00059 S160 Sugiyama TFAM TCF6 TCF6L2 RKAMTKKKELTLLGKPKRPRsAYNVyVAERFQEAKGDsPQE
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q01196 S249 GPS6|EPSD|PSP RUNX1 AML1 CBFA2 stAFNPQPQSQMQDTRQIQPsPPWsyDQsyQyLGSIAsPsV
Q01196 S276 GPS6|EPSD|PSP RUNX1 AML1 CBFA2 QsyQyLGSIAsPsVHPAtPIsPGRASGMTTLSAELSSRLsT
Q01196 T273 GPS6|EPSD|PSP RUNX1 AML1 CBFA2 syDQsyQyLGSIAsPsVHPAtPIsPGRASGMTTLSAELSSR
Q04724 S239 PSP TLE1 EFSNDIKKRKVDDKDSSHYDsDGDKsDDNLVVDVsNEDPss
Q04724 S286 PSP TLE1 HsPRENGIDKNRLLKKDAsssPAstASSASSTSLKSKEMSL
Q04724 S289 PSP TLE1 RENGIDKNRLLKKDAsssPAstASSASSTSLKSKEMSLHEK
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q09472 S2279 PSP EP300 P300 AYQQRLLQQQMGSPVQPNPMsPQQHMLPNQAQSPHLQGQQI
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13363 S422 GPS6|SIGNOR|EPSD|PSP CTBP1 CTBP PSAMSLSHGLPPVAHPPHAPsPGQTVKPEADRDHASDQL__
Q13428 T1014 Sugiyama TCOF1 ARssssEsEDEDVIPAtQCLtPGIRTNVVTMPTAHPRIAPK
Q13573 S182 Sugiyama SNW1 SKIIP SKIP AMPVRAADKLAPAQyIRytPsQQGVAFNsGAKQRVIRMVEM
Q13586 S620 Sugiyama STIM1 GOK sPsAPPGGsPHLDssRsHsPssPDPDtPsPVGDSRALQASR
Q14004 S383 Sugiyama CDK13 CDC2L CDC2L5 CHED KIAA1791 sRRRSPSYSRHSSYERGGDVsPsPyssSsWRRsRsPysPVL
Q14160 S1448 Sugiyama SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL QEDEQPPWAsPsPtsRQsPAsPPPLGGGAPVRTAKAERRHQ
Q14160 S1486 Sugiyama SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL RHQERLRVQsPEPPAPERALsPAELRALEAEKRALWRAARM
Q14247 T401 Sugiyama CTTN EMS1 RQEQEEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVy
Q14258 S100 Sugiyama TRIM25 EFP RNF147 ZNF147 DLAREPPADVWtPPARAsAPsPNAQVACDHCLKEAAVKTCL
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q53EL6 S94 Sugiyama PDCD4 H731 GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q5T0N5 S501 Sugiyama FNBP1L C1orf39 TOCA1 GRGDRRHssDINHLVtQGREsPEGsytDDANQEVRGPPQQH
Q6PD62 S1125 Sugiyama CTR9 KIAA0155 SH2BP1 ESVQSGRSHSGVsENDsRPAsPSAEsDHESERGSDNEGSGQ
Q6UN15 S492 Sugiyama FIP1L1 FIP1 RHE DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15 T494 Sugiyama FIP1L1 FIP1 RHE DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q71RC2 S597 Sugiyama LARP4 PP13296 QttIPVsPPsttKPsRAstAsPCNNNINAAtAVALQEPRKL
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q7L2J0 S69 Sugiyama MEPCE BCDIN3 RGPGRCAPsAGsPAAAVGREsPGAAAtsSSGPQAQQHRGGG
Q7Z2W4 T273 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q7Z5L9 S242 Sugiyama IRF2BP2 ASLGSAQPTDLGAHKRPAsVsssAAVEHEQREAAAKEKQPP
Q86VQ1 T350 Sugiyama GLCCI1 RRAPLPAHYRssstRsIDTQtPsVQERSSSCSSHSPCVSPF
Q86YP4 S100 Sugiyama GATAD2A DGPVDMRTSHSDMKSERRPPsPDVIVLsDNEQPssPRVNGL
Q86Z02 S342 Sugiyama HIPK1 KIAA0630 MYAK NBAK2 MLVDPVRQPYRVKVIDFGSAsHVSKAVCstyLQsRYYRAPE
Q86Z02 Y352 Sugiyama HIPK1 KIAA0630 MYAK NBAK2 RVKVIDFGSAsHVSKAVCstyLQsRYYRAPEIILGLPFCEA
Q8IWW6 S240 Sugiyama ARHGAP12 SSSsTEQIRAttPPNQGRPDsPVyANLQELKISQSALPPLP
Q8IWW6 T231 Sugiyama ARHGAP12 QDSEsGDELSSSsTEQIRAttPPNQGRPDsPVyANLQELKI
Q8IWX8 S817 Sugiyama CHERP DAN26 SCAF6 QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8 T819 Sugiyama CHERP DAN26 SCAF6 RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8IZ21 S118 Sugiyama PHACTR4 PRO2963 PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8ND56 S183 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A GSAFTQDTRsLKtQLsQGRssPQLDPLRKsPtMEQAVQtAs
Q8TEW0 T965 Sugiyama PARD3 PAR3 PAR3A MEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQEKG
Q8WXI9 S122 Sugiyama GATAD2B KIAA1150 DEPVDMSARRsEPERGRLtPsPDIIVLsDNEAssPRsSsRM
Q8WXI9 T120 Sugiyama GATAD2B KIAA1150 INDEPVDMSARRsEPERGRLtPsPDIIVLsDNEAssPRsSs
Q8WY36 S844 Sugiyama BBX HBP2 KRKARKTKITHLVRtADGRVsPAGGTLDDKPKEQLQRSLPK
Q96B36 S212 Sugiyama AKT1S1 PRAS40 GFKEKRtEARssDEENGPPssPDLDRIAAsMRALVLREAED
Q96EB6 S27 EPSD|PSP SIRT1 SIR2L1 LALQPGGsPsAAGADREAAssPAGEPLRKRPRRDGPGLERs
Q96EB6 S682 EPSD|PSP SIRT1 SIR2L1 EDDVLSSsSCGSNSDSGTCQsPSLEEPMEDESEIEEFYNGL
Q96G74 S64 Sugiyama OTUD5 GVGGGDRDRDsGVVGARPRAsPPPQGPLPGPPGALHRWALA
Q96MH2 S76 Sugiyama HEXIM2 L3 EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q99607 S369 PSP ELF4 ELFR MEF EKPKIQHVGLQPSASLELGPsLDEEIPTTSTMLVSPAEGQV
Q9BQ16 T118 Sugiyama SPOCK3 TICN3 UNQ409/PRO771 HKVCIAQDSQTAVCISHRRLtHRMKEAGVDHRQWRGPILST
Q9BY44 S506 Sugiyama EIF2A CDA02 MSTP004 MSTP089 KNQRKHEAKKAAKQEARsDKsPDLAPtPAPQstPRNtVsQs
Q9BY44 T512 Sugiyama EIF2A CDA02 MSTP004 MSTP089 EAKKAAKQEARsDKsPDLAPtPAPQstPRNtVsQsIsGDPE
Q9C0C2 S1103 Sugiyama TNKS1BP1 KIAA1741 TAB182 KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2 S672 Sugiyama TNKS1BP1 KIAA1741 TAB182 TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H2X6 S1013 Sugiyama HIPK2 HHSSSYKSKSSSNVTSTSGHssGSSSGAITYRQQRPGPHFQ
Q9H2X6 S1014 Sugiyama HIPK2 HSSSYKSKSSSNVTSTSGHssGSSSGAITYRQQRPGPHFQQ
Q9H2X6 S118 Sugiyama HIPK2 ASSTSVTGQVLGGPHNLMRRstVsLLDtyQKCGLKRKSEEI
Q9H2X6 S121 Sugiyama HIPK2 TSVTGQVLGGPHNLMRRstVsLLDtyQKCGLKRKSEEIENT
Q9H2X6 S351 Sugiyama HIPK2 MLVDPSRQPYRVKVIDFGSAsHVSKAVCstyLQsRYyRAPE
Q9H2X6 S364 EPSD|PSP HIPK2 VIDFGSAsHVSKAVCstyLQsRYyRAPEIILGLPFCEAIDM
Q9H2X6 S37 Sugiyama HIPK2 PHTLQSSAFCSVKKLKIEPSsNWDMtGyGsHsKVYSQSKNI
Q9H2X6 S441 Sugiyama HIPK2 AEYLLSAGTKTTRFFNRDTDsPYPLWRLKTPDDHEAETGIK
Q9H2X6 S46 Sugiyama HIPK2 CSVKKLKIEPSsNWDMtGyGsHsKVYSQSKNIPLSQPATTT
Q9H2X6 S48 Sugiyama HIPK2 VKKLKIEPSsNWDMtGyGsHsKVYSQSKNIPLSQPATTTVS
Q9H2X6 S668 PSP HIPK2 PDPFQQALIVCPPGFQGLQAsPSKHAGYSVRMENAVPIVTQ
Q9H2X6 S815 Sugiyama HIPK2 PTSTTSSRKSKQHQSSVRNVstCEVSSSQAIssPQRSKRVK
Q9H2X6 S827 PSP|Sugiyama HIPK2 HQSSVRNVstCEVSSSQAIssPQRSKRVKENtPPRCAMVHs
Q9H2X6 S848 PSP HIPK2 PQRSKRVKENtPPRCAMVHssPACstsVTCGWGDVASSTTR
Q9H2X6 S882 SIGNOR|EPSD|PSP HIPK2 VASSTTRERQRQTIVIPDtPsPTVSVITISSDTDEEEEQKH
Q9H2X6 S924 PSP HIPK2 PTSTVSKQRKNVISCVTVHDsPYSDSSSNtsPYSVQQRAGH
Q9H2X6 S934 PSP HIPK2 NVISCVTVHDsPYSDSSSNtsPYSVQQRAGHNNANAFDtKG
Q9H2X6 S955 Sugiyama HIPK2 PYSVQQRAGHNNANAFDtKGsLENHCtGNPRTIIVPPLKTQ
Q9H2X6 S985 Sugiyama HIPK2 RTIIVPPLKTQASEVLVECDsLVPVNtSHHSSSYKSKSSSN
Q9H2X6 T119 Sugiyama HIPK2 SSTSVTGQVLGGPHNLMRRstVsLLDtyQKCGLKRKSEEIE
Q9H2X6 T125 Sugiyama HIPK2 GQVLGGPHNLMRRstVsLLDtyQKCGLKRKSEEIENTSSVQ
Q9H2X6 T42 Sugiyama HIPK2 SSAFCSVKKLKIEPSsNWDMtGyGsHsKVYSQSKNIPLSQP
Q9H2X6 T816 Sugiyama HIPK2 TSTTSSRKSKQHQSSVRNVstCEVSSSQAIssPQRSKRVKE
Q9H2X6 T838 PSP HIPK2 EVSSSQAIssPQRSKRVKENtPPRCAMVHssPACstsVTCG
Q9H2X6 T880 SIGNOR|EPSD|PSP HIPK2 GDVASSTTRERQRQTIVIPDtPsPTVSVITISSDTDEEEEQ
Q9H2X6 T952 Sugiyama HIPK2 NtsPYSVQQRAGHNNANAFDtKGsLENHCtGNPRTIIVPPL
Q9H2X6 T961 Sugiyama HIPK2 RAGHNNANAFDtKGsLENHCtGNPRTIIVPPLKTQASEVLV
Q9H2X6 T991 Sugiyama HIPK2 PLKTQASEVLVECDsLVPVNtSHHSSSYKSKSSSNVTSTSG
Q9H2X6 Y126 Sugiyama HIPK2 QVLGGPHNLMRRstVsLLDtyQKCGLKRKSEEIENTSSVQI
Q9H2X6 Y361 EPSD|PSP|Sugiyama HIPK2 RVKVIDFGSAsHVSKAVCstyLQsRYyRAPEIILGLPFCEA
Q9H2X6 Y44 Sugiyama HIPK2 AFCSVKKLKIEPSsNWDMtGyGsHsKVYSQSKNIPLSQPAT
Q9H3D4 T491 EPSD|PSP TP63 KET P63 P73H P73L TP73L SMNKLPsVsQLINPQQRNALtPTTIPDGMGANIPMMGTHMP
Q9H422 S349 Sugiyama HIPK3 DYRK6 FIST3 PKY MLVDPVRQPYRVKVIDFGSAsHVSKTVCstyLQsRYYRAPE
Q9HC35 S146 Sugiyama EML4 C2orf2 EMAPL4 REKKEEsHsNDQsPQIRAsPsPQPssQPLQIHRQtPEsKNA
Q9NPI6 S523 Sugiyama DCP1A SMIF APSVFQQTVTRSSDLERKAssPsPLtIGtPEsQRKPSIILS
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NWB6 S77 Sugiyama ARGLU1 RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9P1Z0 T795 GPS6|SIGNOR|EPSD|PSP ZBTB4 KIAA1538 KTAAALSRHGQRHAAERPGGtPtPVIAYSKGSAGTRPGDVK
Q9P1Z0 T797 GPS6|SIGNOR|EPSD|PSP ZBTB4 KIAA1538 AAALSRHGQRHAAERPGGtPtPVIAYSKGSAGTRPGDVKEE
Q9P1Z0 T983 GPS6|SIGNOR|EPSD|PSP ZBTB4 KIAA1538 FLPGVFGYAVNPQAAPPAPPtPPPPTLPPPIPPKGEGERAG
Q9UBP0 S268 PSP SPAST ADPSP FSP2 KIAA1083 SPG4 RSKTVMKTGSAGLSGHHRAPsYsGLSMVSGVKQGSGPAPTT
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2V2 S30 Sugiyama CARHSP1 QPPtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRt
Q9Y2V2 S32 Sugiyama CARHSP1 PtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRtFs
Q9Y2V2 S41 Sugiyama CARHSP1 LDtPRsRERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGP
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin organization R-HSA-4839726 9.344916e-09 8.029 0 0
Chromatin modifying enzymes R-HSA-3247509 7.353483e-08 7.134 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.589552e-07 6.018 0 0
NRAGE signals death through JNK R-HSA-193648 1.512955e-05 4.820 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 9.612943e-05 4.017 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.474400e-04 3.831 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.905192e-04 3.408 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.411779e-04 3.355 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.983970e-04 3.223 0 0
Death Receptor Signaling R-HSA-73887 5.595193e-04 3.252 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.900505e-04 3.161 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.431816e-04 3.129 0 0
Regulation of TP53 Expression R-HSA-6804754 1.102114e-03 2.958 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.231522e-03 2.910 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.438810e-03 2.842 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.622048e-03 2.790 1 1
Circadian clock R-HSA-9909396 1.406619e-03 2.852 0 0
HATs acetylate histones R-HSA-3214847 1.593415e-03 2.798 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.153128e-03 2.667 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.992654e-03 2.701 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.139333e-03 2.670 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.402975e-03 2.619 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.752723e-03 2.560 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.752723e-03 2.560 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.654367e-03 2.576 0 0
Cell Cycle R-HSA-1640170 2.789953e-03 2.554 0 0
Regulation of TP53 Activity R-HSA-5633007 3.351600e-03 2.475 1 0
G alpha (12/13) signalling events R-HSA-416482 4.039740e-03 2.394 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.695728e-03 2.328 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.721748e-03 2.326 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.447479e-03 2.352 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.721748e-03 2.326 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.932794e-03 2.227 0 0
Gene expression (Transcription) R-HSA-74160 6.076683e-03 2.216 1 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.908104e-03 2.229 0 0
Cell Cycle, Mitotic R-HSA-69278 7.631380e-03 2.117 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 8.014063e-03 2.096 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.486119e-03 2.071 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.025861e-02 1.989 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 9.564919e-03 2.019 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.125719e-02 1.949 0 0
Kinesins R-HSA-983189 9.961525e-03 2.002 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.098034e-02 1.959 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.125719e-02 1.949 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.076593e-02 1.968 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.250797e-02 1.903 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.231902e-02 1.909 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.231902e-02 1.909 0 0
mRNA Splicing R-HSA-72172 1.154838e-02 1.937 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.129937e-02 1.947 1 0
Specification of primordial germ cells R-HSA-9827857 1.207880e-02 1.918 0 0
Signaling by NTRKs R-HSA-166520 1.199394e-02 1.921 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.477213e-02 1.831 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.477213e-02 1.831 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.499844e-02 1.824 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.548364e-02 1.810 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.585883e-02 1.800 0 0
Nuclear import of Rev protein R-HSA-180746 1.729113e-02 1.762 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.730959e-02 1.762 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.840348e-02 1.735 0 0
Specification of the neural plate border R-HSA-9834899 1.847783e-02 1.733 0 0
RNA Polymerase II Transcription R-HSA-73857 1.799307e-02 1.745 1 0
MET interacts with TNS proteins R-HSA-8875513 1.848975e-02 1.733 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.577484e-02 1.589 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.577484e-02 1.589 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.577484e-02 1.589 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.577484e-02 1.589 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.017378e-02 1.695 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.349936e-02 1.629 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.349936e-02 1.629 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.635399e-02 1.579 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.342688e-02 1.630 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.409772e-02 1.618 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.466394e-02 1.608 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.303752e-02 1.638 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.599879e-02 1.585 0 0
Adipogenesis R-HSA-9843745 2.454236e-02 1.610 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.017378e-02 1.695 0 0
RUNX2 regulates bone development R-HSA-8941326 2.302297e-02 1.638 0 0
Prolonged ERK activation events R-HSA-169893 2.492567e-02 1.603 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.184418e-02 1.661 1 0
G1/S-Specific Transcription R-HSA-69205 2.302297e-02 1.638 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.657031e-02 1.576 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.949852e-02 1.530 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.949852e-02 1.530 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.468954e-02 1.460 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.468954e-02 1.460 0 0
MET receptor recycling R-HSA-8875656 3.468954e-02 1.460 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.468954e-02 1.460 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.362266e-02 1.473 0 0
Repression of WNT target genes R-HSA-4641265 3.362266e-02 1.473 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.128906e-02 1.505 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.496539e-02 1.456 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.205679e-02 1.494 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.053962e-02 1.515 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.948260e-02 1.530 0 0
Mitotic Prometaphase R-HSA-68877 3.335170e-02 1.477 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.362266e-02 1.473 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.128906e-02 1.505 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.053962e-02 1.515 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.083892e-02 1.511 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.421613e-02 1.466 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.199340e-02 1.495 1 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.402371e-02 1.468 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.501998e-02 1.456 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.501998e-02 1.456 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.520902e-02 1.453 0 0
Notch-HLH transcription pathway R-HSA-350054 3.772380e-02 1.423 0 0
mRNA 3'-end processing R-HSA-72187 3.722061e-02 1.429 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.714077e-02 1.430 0 0
M Phase R-HSA-68886 3.645906e-02 1.438 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.839062e-02 1.416 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.839062e-02 1.416 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.578887e-02 1.446 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.772380e-02 1.423 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.839751e-02 1.416 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.848770e-02 1.415 0 0
Apoptotic execution phase R-HSA-75153 4.014377e-02 1.396 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 4.389046e-02 1.358 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 4.389046e-02 1.358 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.326962e-02 1.364 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.326962e-02 1.364 0 0
ALK mutants bind TKIs R-HSA-9700645 4.518074e-02 1.345 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.312916e-02 1.365 0 0
Frs2-mediated activation R-HSA-170968 4.173541e-02 1.379 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.312916e-02 1.365 0 0
Centrosome maturation R-HSA-380287 4.569186e-02 1.340 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.607606e-02 1.337 0 0
NGF-stimulated transcription R-HSA-9031628 4.954611e-02 1.305 0 0
Signaling by NOTCH1 R-HSA-1980143 4.962908e-02 1.304 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.093183e-02 1.293 0 0
Regulation of signaling by CBL R-HSA-912631 5.208878e-02 1.283 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.434969e-02 1.265 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.476315e-02 1.262 0 0
Generic Transcription Pathway R-HSA-212436 5.392378e-02 1.268 1 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.034031e-02 1.298 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.453017e-02 1.263 0 0
Heme signaling R-HSA-9707616 5.034031e-02 1.298 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.376423e-02 1.270 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.500122e-02 1.260 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.500122e-02 1.260 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.724980e-02 1.242 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 7.268543e-02 1.139 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 7.268543e-02 1.139 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 7.268543e-02 1.139 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 7.268543e-02 1.139 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 7.268543e-02 1.139 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 7.268543e-02 1.139 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 7.268543e-02 1.139 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 7.268543e-02 1.139 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 7.268543e-02 1.139 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 7.268543e-02 1.139 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 7.268543e-02 1.139 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.969279e-02 1.224 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.969279e-02 1.224 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.969279e-02 1.224 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.969279e-02 1.224 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.969279e-02 1.224 0 0
Differentiation of T cells R-HSA-9945266 7.259977e-02 1.139 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.259977e-02 1.139 0 0
MET promotes cell motility R-HSA-8875878 6.490404e-02 1.188 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.593559e-02 1.181 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.969279e-02 1.224 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.122127e-02 1.213 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.035754e-02 1.153 1 1
Signal Transduction R-HSA-162582 5.998427e-02 1.222 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.286360e-02 1.137 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.518995e-02 1.186 0 0
DCC mediated attractive signaling R-HSA-418885 6.122127e-02 1.213 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.262199e-02 1.203 0 0
Signaling by ALK R-HSA-201556 7.211929e-02 1.142 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.490404e-02 1.188 0 0
Mitotic Anaphase R-HSA-68882 7.314217e-02 1.136 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.635218e-02 1.117 0 0
Cellular response to heat stress R-HSA-3371556 7.655095e-02 1.116 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.858984e-02 1.105 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 7.865072e-02 1.104 0 0
Regulation of endogenous retroelements R-HSA-9842860 8.074932e-02 1.093 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.415575e-02 1.075 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.042618e-01 0.982 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.042618e-01 0.982 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.042618e-01 0.982 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.042618e-01 0.982 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.042618e-01 0.982 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.976586e-01 0.704 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.976586e-01 0.704 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.976586e-01 0.704 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.976586e-01 0.704 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.976586e-01 0.704 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.976586e-01 0.704 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.976586e-01 0.704 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.976586e-01 0.704 0 0
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-9036092 1.976586e-01 0.704 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.976586e-01 0.704 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.976586e-01 0.704 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 1.058702e-01 0.975 0 0
MET activates PTPN11 R-HSA-8865999 1.058702e-01 0.975 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.422175e-01 0.847 0 0
HCN channels R-HSA-1296061 1.422175e-01 0.847 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.422175e-01 0.847 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.422175e-01 0.847 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.813220e-01 0.551 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.813220e-01 0.551 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.813220e-01 0.551 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.813220e-01 0.551 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.813220e-01 0.551 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.813220e-01 0.551 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.813220e-01 0.551 0 0
Intestinal infectious diseases R-HSA-8942233 2.813220e-01 0.551 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 9.973637e-02 1.001 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 9.973637e-02 1.001 0 0
Regulation of PTEN localization R-HSA-8948747 9.973637e-02 1.001 0 0
SOS-mediated signalling R-HSA-112412 9.973637e-02 1.001 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.807079e-01 0.743 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.807079e-01 0.743 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.807079e-01 0.743 0 0
IRS activation R-HSA-74713 1.807079e-01 0.743 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.807079e-01 0.743 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.807079e-01 0.743 0 0
Type I hemidesmosome assembly R-HSA-446107 1.228789e-01 0.911 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.598777e-02 1.066 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.025313e-01 0.989 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.025313e-01 0.989 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.477486e-01 0.830 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.477486e-01 0.830 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.205002e-01 0.657 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.205002e-01 0.657 0 0
Signaling by RNF43 mutants R-HSA-5340588 2.205002e-01 0.657 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.205002e-01 0.657 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.562659e-01 0.448 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.562659e-01 0.448 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.562659e-01 0.448 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.562659e-01 0.448 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.562659e-01 0.448 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.562659e-01 0.448 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.562659e-01 0.448 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.505081e-02 1.070 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.505081e-02 1.070 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.609048e-01 0.584 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.609048e-01 0.584 0 0
G2/M DNA replication checkpoint R-HSA-69478 2.609048e-01 0.584 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.232858e-02 1.035 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.015773e-01 0.696 0 0
Erythropoietin activates RAS R-HSA-9027284 1.597411e-01 0.797 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.448688e-01 0.839 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.809580e-01 0.742 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.809580e-01 0.742 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.300041e-01 0.638 0 0
Activation of RAC1 R-HSA-428540 2.300041e-01 0.638 0 0
Signaling by AXIN mutants R-HSA-4839735 2.300041e-01 0.638 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.013619e-01 0.521 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.013619e-01 0.521 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.013619e-01 0.521 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.233986e-01 0.373 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.233986e-01 0.373 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.233986e-01 0.373 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 4.233986e-01 0.373 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.233986e-01 0.373 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.233986e-01 0.373 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 4.233986e-01 0.373 0 0
Invadopodia formation R-HSA-8941237 4.233986e-01 0.373 0 0
RAF activation R-HSA-5673000 8.750188e-02 1.058 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.066963e-01 0.972 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.620703e-01 0.790 0 0
MET activates RAS signaling R-HSA-8851805 2.591037e-01 0.587 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.591037e-01 0.587 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.800436e-01 0.745 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.304627e-01 0.885 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.414216e-01 0.467 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.414216e-01 0.467 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.886444e-01 0.540 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.886444e-01 0.540 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.886444e-01 0.540 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.492966e-01 0.603 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.180139e-01 0.662 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.468465e-01 0.833 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.468465e-01 0.833 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.468465e-01 0.833 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.468465e-01 0.833 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.090477e-01 0.680 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.378582e-01 0.624 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.732134e-01 0.563 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.732134e-01 0.563 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.184128e-01 0.497 0 0
ARMS-mediated activation R-HSA-170984 3.807271e-01 0.419 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.807271e-01 0.419 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.835338e-01 0.316 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.835338e-01 0.316 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.835338e-01 0.316 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.835338e-01 0.316 0 0
Signaling by LRP5 mutants R-HSA-5339717 4.835338e-01 0.316 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.774583e-01 0.751 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.938039e-02 1.003 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.361984e-01 0.866 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.152359e-01 0.667 0 0
G0 and Early G1 R-HSA-1538133 2.440813e-01 0.612 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.482148e-01 0.458 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.788752e-01 0.555 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.190002e-01 0.378 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.998919e-01 0.523 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.998919e-01 0.523 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.998919e-01 0.523 0 0
Phosphorylation of the APC/C R-HSA-176412 3.778760e-01 0.423 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.636258e-01 0.579 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.470788e-01 0.832 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.466693e-01 0.460 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.211455e-01 0.493 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.211455e-01 0.493 0 0
HIV elongation arrest and recovery R-HSA-167287 3.211455e-01 0.493 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.211455e-01 0.493 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.893723e-01 0.723 0 0
MAP2K and MAPK activation R-HSA-5674135 2.974204e-01 0.527 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 2.974204e-01 0.527 0 0
HIV Transcription Initiation R-HSA-167161 2.974204e-01 0.527 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 2.974204e-01 0.527 0 0
Signaling by Erythropoietin R-HSA-9006335 3.425620e-01 0.465 0 0
Late endosomal microautophagy R-HSA-9615710 3.425620e-01 0.465 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.713511e-01 0.430 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 4.072419e-01 0.390 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.072419e-01 0.390 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.560289e-01 0.341 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.560289e-01 0.341 0 0
Signaling by APC mutants R-HSA-4839744 4.560289e-01 0.341 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.560289e-01 0.341 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.560289e-01 0.341 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.560289e-01 0.341 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.374005e-01 0.270 0 0
G2 Phase R-HSA-68911 5.374005e-01 0.270 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.374005e-01 0.270 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.374005e-01 0.270 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.374005e-01 0.270 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.374005e-01 0.270 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.320683e-01 0.479 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.427258e-01 0.465 0 0
Deadenylation of mRNA R-HSA-429947 4.204114e-01 0.376 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.916567e-01 0.308 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.916567e-01 0.308 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.916567e-01 0.308 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.687927e-01 0.571 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.672506e-01 0.435 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.590205e-01 0.445 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.446166e-01 0.352 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.147380e-01 0.382 0 0
Separation of Sister Chromatids R-HSA-2467813 2.815209e-01 0.550 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.923031e-01 0.308 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.257730e-01 0.279 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.257730e-01 0.279 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.257730e-01 0.279 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.257730e-01 0.279 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.257730e-01 0.279 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.257730e-01 0.279 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.257730e-01 0.279 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.257730e-01 0.279 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.257730e-01 0.279 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.856518e-01 0.232 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.856518e-01 0.232 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.856518e-01 0.232 0 0
PDE3B signalling R-HSA-165160 5.856518e-01 0.232 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.856518e-01 0.232 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.856518e-01 0.232 0 0
PKB-mediated events R-HSA-109703 5.856518e-01 0.232 0 0
Phosphorylation of Emi1 R-HSA-176417 5.856518e-01 0.232 0 0
Signaling by MAPK mutants R-HSA-9652817 5.856518e-01 0.232 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.917891e-01 0.407 0 0
Negative regulation of MET activity R-HSA-6807004 5.193110e-01 0.285 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.193110e-01 0.285 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.193110e-01 0.285 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.193110e-01 0.285 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.193110e-01 0.285 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.193110e-01 0.285 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.376122e-01 0.270 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.376122e-01 0.270 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.277758e-01 0.278 0 0
Nucleosome assembly R-HSA-774815 5.277758e-01 0.278 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.596253e-01 0.252 0 0
Activation of the pre-replicative complex R-HSA-68962 5.596253e-01 0.252 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.288728e-01 0.201 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.288728e-01 0.201 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.184823e-01 0.209 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.184823e-01 0.209 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.184823e-01 0.209 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.188600e-01 0.208 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.188600e-01 0.208 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.188600e-01 0.208 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.262051e-01 0.203 0 0
HSF1-dependent transactivation R-HSA-3371571 6.307945e-01 0.200 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.414417e-01 0.193 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 6.675877e-01 0.175 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.675877e-01 0.175 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.675877e-01 0.175 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.675877e-01 0.175 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.675877e-01 0.175 0 0
Recycling of eIF2:GDP R-HSA-72731 6.675877e-01 0.175 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.675877e-01 0.175 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.675877e-01 0.175 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.604270e-01 0.180 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.630635e-01 0.178 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.721404e-01 0.173 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.370976e-01 0.472 0 0
Transcription of the HIV genome R-HSA-167172 2.218118e-01 0.654 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.060998e-01 0.514 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.015964e-01 0.521 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.262051e-01 0.203 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.744763e-01 0.324 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.744763e-01 0.324 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.744763e-01 0.324 0 0
PTEN Regulation R-HSA-6807070 2.059091e-01 0.686 0 0
Signaling by NOTCH3 R-HSA-9012852 2.624028e-01 0.581 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.030417e-01 0.692 0 0
Polo-like kinase mediated events R-HSA-156711 1.130477e-01 0.947 0 0
Aggrephagy R-HSA-9646399 2.636258e-01 0.579 0 0
HIV Transcription Elongation R-HSA-167169 4.147380e-01 0.382 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.636258e-01 0.579 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.636258e-01 0.579 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.713511e-01 0.430 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.269686e-01 0.896 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.708730e-01 0.243 0 0
Signaling by MET R-HSA-6806834 1.793699e-01 0.746 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.886444e-01 0.540 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.706979e-01 0.768 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.974919e-01 0.527 0 0
Regulation of CDH11 function R-HSA-9762292 4.190002e-01 0.378 0 0
Neurexins and neuroligins R-HSA-6794361 2.208824e-01 0.656 0 0
Nucleotide Excision Repair R-HSA-5696398 6.354757e-01 0.197 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.591037e-01 0.587 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.220145e-01 0.492 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.381225e-01 0.860 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.534347e-01 0.596 1 1
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.147380e-01 0.382 0 0
Signaling by ERBB2 R-HSA-1227986 6.205042e-01 0.207 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.013619e-01 0.521 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 2.258640e-01 0.646 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.920023e-01 0.308 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.892137e-01 0.230 0 0
Formation of the posterior neural plate R-HSA-9832991 2.015773e-01 0.696 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.190002e-01 0.378 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.916567e-01 0.308 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.284795e-01 0.368 0 0
Meiotic synapsis R-HSA-1221632 6.620561e-01 0.179 0 0
Interleukin-15 signaling R-HSA-8983432 5.257730e-01 0.279 0 0
DAP12 signaling R-HSA-2424491 5.596253e-01 0.252 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.072419e-01 0.390 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.923031e-01 0.308 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.708730e-01 0.243 0 0
Signaling by WNT in cancer R-HSA-4791275 1.304627e-01 0.885 0 0
DNA Double Strand Break Response R-HSA-5693606 2.100695e-01 0.678 0 0
PI3K/AKT activation R-HSA-198203 1.740716e-01 0.759 0 0
Formation of apoptosome R-HSA-111458 4.190002e-01 0.378 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.998919e-01 0.523 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.273049e-01 0.895 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.954190e-01 0.403 0 0
Signaling by EGFR R-HSA-177929 4.082485e-01 0.389 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.856518e-01 0.232 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.517530e-01 0.258 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.770531e-01 0.239 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.596253e-01 0.252 0 0
RNA Polymerase I Transcription R-HSA-73864 6.048262e-01 0.218 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.591037e-01 0.587 0 0
Signaling by RAS mutants R-HSA-6802949 1.468465e-01 0.833 0 0
Cardiogenesis R-HSA-9733709 2.622057e-01 0.581 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.604270e-01 0.180 0 0
p75NTR signals via NF-kB R-HSA-193639 3.482148e-01 0.458 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.701490e-01 0.769 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.119277e-01 0.291 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.596253e-01 0.252 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.160589e-01 0.381 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.257530e-01 0.900 0 0
Hedgehog 'on' state R-HSA-5632684 1.682181e-01 0.774 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.813220e-01 0.551 0 0
TGFBR3 expression R-HSA-9839394 1.309382e-01 0.883 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.492966e-01 0.603 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.180139e-01 0.662 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.807271e-01 0.419 0 0
Regulation of gap junction activity R-HSA-191650 4.835338e-01 0.316 0 0
Ligand-receptor interactions R-HSA-5632681 5.856518e-01 0.232 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.897310e-01 0.310 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.184823e-01 0.209 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.675877e-01 0.175 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.185258e-01 0.209 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.713511e-01 0.430 0 0
Nuclear RNA decay R-HSA-9930044 1.432554e-01 0.844 0 0
Laminin interactions R-HSA-3000157 6.630635e-01 0.178 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.942531e-01 0.712 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 4.573839e-01 0.340 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.305241e-01 0.481 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.727974e-01 0.429 0 0
Hedgehog 'off' state R-HSA-5610787 4.494386e-01 0.347 0 0
FOXO-mediated transcription R-HSA-9614085 5.515148e-01 0.258 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.336565e-01 0.363 0 0
Signal attenuation R-HSA-74749 1.740716e-01 0.759 0 0
Rap1 signalling R-HSA-392517 2.732134e-01 0.563 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.152359e-01 0.667 0 0
Long-term potentiation R-HSA-9620244 4.446166e-01 0.352 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.727974e-01 0.429 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.257730e-01 0.279 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.604270e-01 0.180 0 0
Homology Directed Repair R-HSA-5693538 2.913395e-01 0.536 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.531218e-01 0.344 0 0
Cilium Assembly R-HSA-5617833 2.922425e-01 0.534 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.371847e-01 0.270 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.581714e-01 0.588 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.497077e-01 0.347 0 0
Signaling by NOTCH R-HSA-157118 5.726057e-01 0.242 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.120630e-01 0.385 0 0
RNA Polymerase III Transcription R-HSA-74158 5.119277e-01 0.291 0 0
Insulin receptor signalling cascade R-HSA-74751 6.782237e-01 0.169 0 0
Cellular Senescence R-HSA-2559583 2.807080e-01 0.552 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.121002e-01 0.506 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.807079e-01 0.743 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.620703e-01 0.790 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.258640e-01 0.646 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.057538e-01 0.976 0 0
Calcineurin activates NFAT R-HSA-2025928 3.807271e-01 0.419 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.853525e-01 0.732 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.374005e-01 0.270 0 0
IRS-mediated signalling R-HSA-112399 5.737133e-01 0.241 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.220570e-01 0.206 0 0
PTK6 Expression R-HSA-8849473 6.675877e-01 0.175 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.675877e-01 0.175 0 0
Signalling to ERKs R-HSA-187687 9.690827e-02 1.014 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.745954e-01 0.324 0 0
Cyclin D associated events in G1 R-HSA-69231 2.188871e-01 0.660 0 0
G1 Phase R-HSA-69236 2.188871e-01 0.660 0 0
IGF1R signaling cascade R-HSA-2428924 5.371622e-01 0.270 0 0
Signaling by Hedgehog R-HSA-5358351 3.506476e-01 0.455 0 0
UCH proteinases R-HSA-5689603 2.212978e-01 0.655 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.504307e-01 0.601 0 0
Oncogene Induced Senescence R-HSA-2559585 3.183619e-01 0.497 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.257730e-01 0.279 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.493110e-01 0.260 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.361984e-01 0.866 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.217467e-01 0.654 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.217467e-01 0.654 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.217467e-01 0.654 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.217467e-01 0.654 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.422075e-01 0.616 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.579830e-01 0.801 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.685026e-01 0.329 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 9.576195e-02 1.019 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.422175e-01 0.847 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.422175e-01 0.847 0 0
Signaling by LTK R-HSA-9842663 1.025313e-01 0.989 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 2.205002e-01 0.657 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.232858e-02 1.035 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.233986e-01 0.373 0 0
HDACs deacetylate histones R-HSA-3214815 2.624028e-01 0.581 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 4.916567e-01 0.308 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.872880e-01 0.412 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.685026e-01 0.329 0 0
MET Receptor Activation R-HSA-6806942 6.288728e-01 0.201 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.497077e-01 0.347 0 0
G1/S Transition R-HSA-69206 5.767663e-01 0.239 0 0
HDMs demethylate histones R-HSA-3214842 1.309382e-01 0.883 0 0
TNF signaling R-HSA-75893 1.014385e-01 0.994 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.765114e-01 0.239 0 0
Signaling by FGFR4 R-HSA-5654743 6.605482e-01 0.180 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.525987e-01 0.258 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.537284e-01 0.185 0 0
Neurofascin interactions R-HSA-447043 2.609048e-01 0.584 0 0
Vasopressin-like receptors R-HSA-388479 4.835338e-01 0.316 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.803963e-01 0.552 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.974204e-01 0.527 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.916567e-01 0.308 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.645639e-01 0.333 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.685026e-01 0.329 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.920023e-01 0.308 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.184823e-01 0.209 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.184823e-01 0.209 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.401149e-01 0.194 0 0
Signaling by Hippo R-HSA-2028269 9.854629e-02 1.006 0 0
Mitotic Prophase R-HSA-68875 1.105895e-01 0.956 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.395175e-01 0.855 1 1
DNA Repair R-HSA-73894 3.311594e-01 0.480 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.605025e-01 0.180 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.394421e-01 0.856 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.204114e-01 0.376 0 0
Cell junction organization R-HSA-446728 4.406594e-01 0.356 0 0
Interleukin-2 family signaling R-HSA-451927 5.899274e-01 0.229 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.680776e-01 0.572 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.448844e-01 0.611 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.789406e-01 0.554 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.856017e-01 0.414 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 4.446166e-01 0.352 0 0
Selective autophagy R-HSA-9663891 3.824840e-01 0.417 0 0
Deubiquitination R-HSA-5688426 9.593222e-02 1.018 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.778760e-01 0.423 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.635742e-01 0.178 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.599109e-01 0.796 0 0
MTOR signalling R-HSA-165159 6.436536e-01 0.191 0 0
G2/M Transition R-HSA-69275 1.994439e-01 0.700 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.511948e-01 0.346 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.790005e-01 0.554 0 0
SDK interactions R-HSA-373756 1.976586e-01 0.704 0 0
NrCAM interactions R-HSA-447038 1.807079e-01 0.743 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.562659e-01 0.448 0 0
TGFBR3 regulates activin signaling R-HSA-9839406 3.562659e-01 0.448 0 0
Regulation of KIT signaling R-HSA-1433559 1.395175e-01 0.855 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.130477e-01 0.947 0 0
MET activates STAT3 R-HSA-8875791 4.233986e-01 0.373 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.233986e-01 0.373 0 0
Disorders of Developmental Biology R-HSA-9675151 2.030417e-01 0.692 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.800436e-01 0.745 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.886444e-01 0.540 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.886444e-01 0.540 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.566224e-01 0.805 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.359022e-01 0.867 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.807271e-01 0.419 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.835338e-01 0.316 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.835338e-01 0.316 0 0
snRNP Assembly R-HSA-191859 2.093100e-01 0.679 0 0
Metabolism of non-coding RNA R-HSA-194441 2.093100e-01 0.679 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.466693e-01 0.460 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.344651e-01 0.630 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.374005e-01 0.270 0 0
Mitochondrial biogenesis R-HSA-1592230 2.035075e-01 0.691 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 4.361769e-01 0.360 0 0
NF-kB is activated and signals survival R-HSA-209560 4.916567e-01 0.308 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.916567e-01 0.308 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.916567e-01 0.308 0 0
PKA activation in glucagon signalling R-HSA-164378 4.645639e-01 0.333 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.819213e-01 0.550 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.147380e-01 0.382 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.856518e-01 0.232 0 0
Sensory perception of salty taste R-HSA-9730628 5.856518e-01 0.232 0 0
Synthesis of PS R-HSA-1483101 5.856518e-01 0.232 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.163566e-01 0.381 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.281040e-01 0.368 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.583056e-01 0.253 0 0
Budding and maturation of HIV virion R-HSA-162588 5.810573e-01 0.236 0 0
mTORC1-mediated signalling R-HSA-166208 5.953302e-01 0.225 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 6.184823e-01 0.209 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.052199e-01 0.218 0 0
PI3K Cascade R-HSA-109704 6.145470e-01 0.211 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.604270e-01 0.180 0 0
Signaling by ALK in cancer R-HSA-9700206 2.448844e-01 0.611 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.575231e-01 0.254 0 0
Cell-Cell communication R-HSA-1500931 5.222153e-01 0.282 0 0
Membrane Trafficking R-HSA-199991 1.746730e-01 0.758 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.468465e-01 0.833 0 0
Rab regulation of trafficking R-HSA-9007101 2.811975e-01 0.551 0 0
Cell Cycle Checkpoints R-HSA-69620 1.420213e-01 0.848 0 0
Activation of BH3-only proteins R-HSA-114452 3.640702e-01 0.439 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.645639e-01 0.333 0 0
PI Metabolism R-HSA-1483255 1.262539e-01 0.899 0 0
Collagen degradation R-HSA-1442490 4.897310e-01 0.310 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.184128e-01 0.497 0 0
Signaling by VEGF R-HSA-194138 5.767663e-01 0.239 0 0
Pexophagy R-HSA-9664873 4.190002e-01 0.378 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.552063e-01 0.342 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.710610e-01 0.243 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.597411e-01 0.797 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.184823e-01 0.209 0 0
HIV Life Cycle R-HSA-162587 1.178018e-01 0.929 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.361769e-01 0.360 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.361769e-01 0.360 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.721404e-01 0.173 0 0
Gastrulation R-HSA-9758941 3.001160e-01 0.523 0 0
Downstream signal transduction R-HSA-186763 2.263441e-01 0.645 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.455192e-01 0.263 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.455192e-01 0.263 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.622057e-01 0.581 0 0
Myogenesis R-HSA-525793 4.685026e-01 0.329 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.193110e-01 0.285 0 0
Recycling pathway of L1 R-HSA-437239 5.635131e-01 0.249 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 8.977237e-02 1.047 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.810573e-01 0.236 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.217467e-01 0.654 0 0
RMTs methylate histone arginines R-HSA-3214858 3.496123e-01 0.456 0 0
Signaling by NOTCH2 R-HSA-1980145 6.604270e-01 0.180 0 0
Pervasive developmental disorders R-HSA-9005895 2.591037e-01 0.587 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.591037e-01 0.587 0 0
Disorders of Nervous System Development R-HSA-9697154 2.591037e-01 0.587 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.414216e-01 0.467 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.835338e-01 0.316 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 5.892137e-01 0.230 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.220570e-01 0.206 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.675877e-01 0.175 0 0
Mitophagy R-HSA-5205647 6.604270e-01 0.180 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.536200e-01 0.185 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.284795e-01 0.368 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.536200e-01 0.185 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.536200e-01 0.185 0 0
Signaling by TGFB family members R-HSA-9006936 1.340493e-01 0.873 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.727974e-01 0.429 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 9.973637e-02 1.001 0 0
RET signaling R-HSA-8853659 1.068641e-01 0.971 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.603172e-01 0.795 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.807271e-01 0.419 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.583056e-01 0.253 0 0
MAP kinase activation R-HSA-450294 4.897310e-01 0.310 0 0
HIV Infection R-HSA-162906 6.176821e-01 0.209 0 0
Interleukin-17 signaling R-HSA-448424 4.891701e-01 0.311 0 0
L1CAM interactions R-HSA-373760 5.689242e-01 0.245 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.434194e-01 0.265 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.708730e-01 0.243 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.378582e-01 0.624 0 0
Neurodegenerative Diseases R-HSA-8863678 2.378582e-01 0.624 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.334425e-01 0.632 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.517530e-01 0.258 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.813220e-01 0.551 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.740716e-01 0.759 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.130477e-01 0.947 0 0
Activation of SMO R-HSA-5635838 1.809580e-01 0.742 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.233986e-01 0.373 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 1.620703e-01 0.790 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.014385e-01 0.994 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 1.705357e-01 0.768 0 0
Sensory perception of sour taste R-HSA-9729555 4.835338e-01 0.316 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.220145e-01 0.492 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.072419e-01 0.390 0 0
Synthesis of PI R-HSA-1483226 4.560289e-01 0.341 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.204114e-01 0.376 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.856518e-01 0.232 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.892137e-01 0.230 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.892137e-01 0.230 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.184823e-01 0.209 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.220570e-01 0.206 0 0
Negative regulation of FLT3 R-HSA-9706369 6.461171e-01 0.190 0 0
VLDL clearance R-HSA-8964046 6.675877e-01 0.175 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.675877e-01 0.175 0 0
Apoptosis R-HSA-109581 6.040179e-01 0.219 0 0
Signaling by PTK6 R-HSA-8848021 5.215257e-01 0.283 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.215257e-01 0.283 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.425620e-01 0.465 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.788752e-01 0.555 0 0
Signaling by TGFBR3 R-HSA-9839373 3.849452e-01 0.415 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.531218e-01 0.344 0 0
Programmed Cell Death R-HSA-5357801 6.677422e-01 0.175 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.477486e-01 0.830 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.911106e-01 0.228 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.477486e-01 0.830 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.218118e-01 0.654 0 0
Tie2 Signaling R-HSA-210993 4.645639e-01 0.333 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.284795e-01 0.368 0 0
ERK/MAPK targets R-HSA-198753 5.455192e-01 0.263 0 0
TBC/RABGAPs R-HSA-8854214 6.605482e-01 0.180 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.046861e-01 0.689 0 0
FLT3 signaling in disease R-HSA-9682385 5.119277e-01 0.291 0 0
Formation of the anterior neural plate R-HSA-9823739 3.482148e-01 0.458 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.180942e-01 0.661 0 0
Signaling by PDGF R-HSA-186797 5.057085e-01 0.296 0 0
Signaling by SCF-KIT R-HSA-1433557 4.908970e-01 0.309 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.809580e-01 0.742 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.013619e-01 0.521 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.013619e-01 0.521 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.432554e-01 0.844 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.835338e-01 0.316 0 0
Dopamine receptors R-HSA-390651 4.835338e-01 0.316 0 0
Collagen chain trimerization R-HSA-8948216 3.567502e-01 0.448 0 0
Anchoring fibril formation R-HSA-2214320 4.916567e-01 0.308 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.685026e-01 0.329 0 0
Relaxin receptors R-HSA-444821 5.856518e-01 0.232 0 0
Formation of axial mesoderm R-HSA-9796292 5.583056e-01 0.253 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.320313e-01 0.274 0 0
CREB phosphorylation R-HSA-199920 6.288728e-01 0.201 0 0
Signaling by LTK in cancer R-HSA-9842640 6.288728e-01 0.201 0 0
NADPH regeneration R-HSA-389542 6.288728e-01 0.201 0 0
Fibronectin matrix formation R-HSA-1566977 6.721404e-01 0.173 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.220145e-01 0.492 0 0
FLT3 Signaling R-HSA-9607240 4.339863e-01 0.363 0 0
Sensory processing of sound R-HSA-9659379 2.560744e-01 0.592 0 0
Nephrin family interactions R-HSA-373753 5.193110e-01 0.285 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.959620e-01 0.402 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.257730e-01 0.279 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.604270e-01 0.180 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.731220e-01 0.762 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.183679e-01 0.209 0 0
Inositol phosphate metabolism R-HSA-1483249 2.140705e-01 0.669 0 0
Netrin-1 signaling R-HSA-373752 3.496123e-01 0.456 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.807079e-01 0.743 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.414216e-01 0.467 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.414216e-01 0.467 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.468465e-01 0.833 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.361769e-01 0.360 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.856518e-01 0.232 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.856518e-01 0.232 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.856518e-01 0.232 0 0
PKR-mediated signaling R-HSA-9833482 6.316657e-01 0.200 0 0
CHL1 interactions R-HSA-447041 6.675877e-01 0.175 0 0
CREB3 factors activate genes R-HSA-8874211 6.288728e-01 0.201 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.923031e-01 0.308 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.461171e-01 0.190 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.015733e-01 0.696 0 0
Gene Silencing by RNA R-HSA-211000 6.579176e-01 0.182 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.374005e-01 0.270 0 0
tRNA processing in the nucleus R-HSA-6784531 3.665754e-01 0.436 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.339811e-01 0.873 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.738646e-01 0.760 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.374005e-01 0.270 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.892137e-01 0.230 0 0
Interleukin-7 signaling R-HSA-1266695 4.446166e-01 0.352 0 0
Signaling by Leptin R-HSA-2586552 4.190002e-01 0.378 0 0
Interleukin-37 signaling R-HSA-9008059 2.090477e-01 0.680 0 0
Growth hormone receptor signaling R-HSA-982772 6.188600e-01 0.208 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 6.785915e-01 0.168 0 0
Signaling by FGFR in disease R-HSA-1226099 6.800335e-01 0.167 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.822452e-01 0.166 0 0
MET activates PTK2 signaling R-HSA-8874081 6.837217e-01 0.165 0 0
Metalloprotease DUBs R-HSA-5689901 6.837217e-01 0.165 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.837217e-01 0.165 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.837217e-01 0.165 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 6.837217e-01 0.165 0 0
Metabolism of RNA R-HSA-8953854 6.882252e-01 0.162 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.927482e-01 0.159 0 0
Signaling by FGFR3 R-HSA-5654741 6.927482e-01 0.159 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.929164e-01 0.159 0 0
Adherens junctions interactions R-HSA-418990 6.946757e-01 0.158 0 0
G2/M Checkpoints R-HSA-69481 6.957679e-01 0.158 0 0
GPVI-mediated activation cascade R-HSA-114604 6.960664e-01 0.157 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.965876e-01 0.157 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.965876e-01 0.157 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.965876e-01 0.157 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.965876e-01 0.157 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.022659e-01 0.153 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.022659e-01 0.153 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.022659e-01 0.153 0 0
Adrenoceptors R-HSA-390696 7.022659e-01 0.153 0 0
Formation of annular gap junctions R-HSA-196025 7.022659e-01 0.153 0 0
Co-stimulation by ICOS R-HSA-9927354 7.022659e-01 0.153 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.022659e-01 0.153 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.022659e-01 0.153 0 0
Sodium/Proton exchangers R-HSA-425986 7.022659e-01 0.153 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.022659e-01 0.153 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.034192e-01 0.153 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.034192e-01 0.153 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.034192e-01 0.153 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.034192e-01 0.153 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.034192e-01 0.153 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.070819e-01 0.151 0 0
Diseases of DNA repair R-HSA-9675135 7.080413e-01 0.150 0 0
NCAM1 interactions R-HSA-419037 7.128498e-01 0.147 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.176883e-01 0.144 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.195044e-01 0.143 0 0
Apoptotic factor-mediated response R-HSA-111471 7.195044e-01 0.143 0 0
Mismatch Repair R-HSA-5358508 7.195044e-01 0.143 0 0
PKA activation R-HSA-163615 7.195044e-01 0.143 0 0
Telomere Extension By Telomerase R-HSA-171319 7.221650e-01 0.141 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.221650e-01 0.141 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.221650e-01 0.141 0 0
MAPK family signaling cascades R-HSA-5683057 7.278364e-01 0.138 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.289436e-01 0.137 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.291344e-01 0.137 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.291344e-01 0.137 0 0
Gap junction degradation R-HSA-190873 7.333283e-01 0.135 0 0
Unwinding of DNA R-HSA-176974 7.333283e-01 0.135 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.333283e-01 0.135 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.333283e-01 0.135 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.333283e-01 0.135 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.333283e-01 0.135 0 0
Lipophagy R-HSA-9613354 7.333283e-01 0.135 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.333283e-01 0.135 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.333283e-01 0.135 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.333283e-01 0.135 0 0
S Phase R-HSA-69242 7.358938e-01 0.133 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.370015e-01 0.133 0 0
mRNA Capping R-HSA-72086 7.399732e-01 0.131 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.399732e-01 0.131 0 0
DARPP-32 events R-HSA-180024 7.399732e-01 0.131 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.399732e-01 0.131 0 0
MHC class II antigen presentation R-HSA-2132295 7.403811e-01 0.131 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.409439e-01 0.130 0 0
Crosslinking of collagen fibrils R-HSA-2243919 7.409439e-01 0.130 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.409439e-01 0.130 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.409439e-01 0.130 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.409439e-01 0.130 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.511891e-01 0.124 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.537415e-01 0.123 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.568622e-01 0.121 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.609649e-01 0.119 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.609649e-01 0.119 0 0
Formation of definitive endoderm R-HSA-9823730 7.609649e-01 0.119 0 0
Signaling by NODAL R-HSA-1181150 7.609649e-01 0.119 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.611516e-01 0.119 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.611516e-01 0.119 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.611516e-01 0.119 0 0
DNA replication initiation R-HSA-68952 7.611516e-01 0.119 0 0
Josephin domain DUBs R-HSA-5689877 7.611516e-01 0.119 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.611516e-01 0.119 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.611516e-01 0.119 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.611516e-01 0.119 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.611516e-01 0.119 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.611516e-01 0.119 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.611516e-01 0.119 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.611516e-01 0.119 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.611516e-01 0.119 0 0
Vesicle-mediated transport R-HSA-5653656 7.644566e-01 0.117 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.670939e-01 0.115 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.696084e-01 0.114 0 0
EGFR downregulation R-HSA-182971 7.728539e-01 0.112 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.728539e-01 0.112 0 0
Trafficking of AMPA receptors R-HSA-399719 7.728539e-01 0.112 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.731489e-01 0.112 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.731489e-01 0.112 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.759787e-01 0.110 0 0
Glycolysis R-HSA-70171 7.773440e-01 0.109 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.796298e-01 0.108 0 0
Signalling to RAS R-HSA-167044 7.796298e-01 0.108 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.796298e-01 0.108 0 0
Basigin interactions R-HSA-210991 7.796298e-01 0.108 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.810543e-01 0.107 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.810543e-01 0.107 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.822912e-01 0.107 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.834259e-01 0.106 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.834259e-01 0.106 0 0
Ub-specific processing proteases R-HSA-5689880 7.834259e-01 0.106 0 0
Cell-cell junction organization R-HSA-421270 7.854113e-01 0.105 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.860734e-01 0.105 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.860734e-01 0.105 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.860734e-01 0.105 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.860734e-01 0.105 0 0
Interleukin-2 signaling R-HSA-9020558 7.860734e-01 0.105 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.860734e-01 0.105 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.860734e-01 0.105 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.860734e-01 0.105 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.860734e-01 0.105 0 0
vRNA Synthesis R-HSA-192814 7.860734e-01 0.105 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.860734e-01 0.105 0 0
Bicarbonate transporters R-HSA-425381 7.860734e-01 0.105 0 0
Transport of RCbl within the body R-HSA-9758890 7.860734e-01 0.105 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.860734e-01 0.105 0 0
LGI-ADAM interactions R-HSA-5682910 7.860734e-01 0.105 0 0
PECAM1 interactions R-HSA-210990 7.860734e-01 0.105 0 0
Suppression of apoptosis R-HSA-9635465 7.860734e-01 0.105 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.884866e-01 0.103 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.884866e-01 0.103 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.884866e-01 0.103 0 0
Semaphorin interactions R-HSA-373755 7.920649e-01 0.101 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.920649e-01 0.101 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.949021e-01 0.100 0 0
Autophagy R-HSA-9612973 7.967352e-01 0.099 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.970038e-01 0.099 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.970038e-01 0.099 0 0
Assembly Of The HIV Virion R-HSA-175474 7.970038e-01 0.099 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.000518e-01 0.097 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.000518e-01 0.097 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.000518e-01 0.097 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.000518e-01 0.097 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.022470e-01 0.096 0 0
Integrin signaling R-HSA-354192 8.022470e-01 0.096 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.022470e-01 0.096 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.035871e-01 0.095 0 0
Nervous system development R-HSA-9675108 8.044140e-01 0.095 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.062594e-01 0.094 0 0
Chromosome Maintenance R-HSA-73886 8.071861e-01 0.093 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.083961e-01 0.092 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.083961e-01 0.092 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.083961e-01 0.092 0 0
ERKs are inactivated R-HSA-202670 8.083961e-01 0.092 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.083961e-01 0.092 0 0
DS-GAG biosynthesis R-HSA-2022923 8.083961e-01 0.092 0 0
Integration of provirus R-HSA-162592 8.083961e-01 0.092 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.091092e-01 0.092 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.116374e-01 0.091 0 0
Reproduction R-HSA-1474165 8.130044e-01 0.090 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.131529e-01 0.090 0 0
FGFR2 alternative splicing R-HSA-6803529 8.131529e-01 0.090 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.131529e-01 0.090 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.131529e-01 0.090 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.131529e-01 0.090 0 0
Signaling by KIT in disease R-HSA-9669938 8.131529e-01 0.090 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.149244e-01 0.089 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.157045e-01 0.088 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.157045e-01 0.088 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.157045e-01 0.088 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.167967e-01 0.088 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.191793e-01 0.087 0 0
RSV-host interactions R-HSA-9833110 8.195607e-01 0.086 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.216786e-01 0.085 0 0
DAP12 interactions R-HSA-2172127 8.230082e-01 0.085 0 0
Macroautophagy R-HSA-1632852 8.253144e-01 0.083 0 0
Carnitine shuttle R-HSA-200425 8.281434e-01 0.082 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.281434e-01 0.082 0 0
Syndecan interactions R-HSA-3000170 8.281434e-01 0.082 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.283761e-01 0.082 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.283761e-01 0.082 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.283761e-01 0.082 0 0
Leading Strand Synthesis R-HSA-69109 8.283907e-01 0.082 0 0
Polymerase switching R-HSA-69091 8.283907e-01 0.082 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.283907e-01 0.082 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.283907e-01 0.082 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.283907e-01 0.082 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.283907e-01 0.082 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.283907e-01 0.082 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.283907e-01 0.082 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.283907e-01 0.082 0 0
OAS antiviral response R-HSA-8983711 8.283907e-01 0.082 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.309860e-01 0.080 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.314722e-01 0.080 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.317627e-01 0.080 0 0
Signaling by FGFR1 R-HSA-5654736 8.317627e-01 0.080 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.339540e-01 0.079 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.339540e-01 0.079 0 0
Diseases of programmed cell death R-HSA-9645723 8.357238e-01 0.078 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.402930e-01 0.076 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.402930e-01 0.076 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.402930e-01 0.076 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 8.408218e-01 0.075 0 0
Regulated Necrosis R-HSA-5218859 8.408218e-01 0.075 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.420413e-01 0.075 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.420413e-01 0.075 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.420413e-01 0.075 0 0
Axon guidance R-HSA-422475 8.435788e-01 0.074 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.443286e-01 0.073 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.462999e-01 0.072 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.462999e-01 0.072 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.462999e-01 0.072 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.462999e-01 0.072 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.462999e-01 0.072 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.462999e-01 0.072 0 0
Processing of SMDT1 R-HSA-8949664 8.462999e-01 0.072 0 0
Maturation of nucleoprotein R-HSA-9683610 8.462999e-01 0.072 0 0
Interleukin-6 signaling R-HSA-1059683 8.462999e-01 0.072 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.462999e-01 0.072 0 0
Signaling by FGFR2 R-HSA-5654738 8.497255e-01 0.071 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.497255e-01 0.071 0 0
Calmodulin induced events R-HSA-111933 8.514870e-01 0.070 0 0
CaM pathway R-HSA-111997 8.514870e-01 0.070 0 0
Triglyceride catabolism R-HSA-163560 8.514870e-01 0.070 0 0
PPARA activates gene expression R-HSA-1989781 8.540772e-01 0.069 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.541513e-01 0.068 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.541513e-01 0.068 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.549114e-01 0.068 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.549114e-01 0.068 0 0
COPII-mediated vesicle transport R-HSA-204005 8.575419e-01 0.067 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.575419e-01 0.067 0 0
Extension of Telomeres R-HSA-180786 8.592477e-01 0.066 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.619903e-01 0.064 0 0
Removal of the Flap Intermediate R-HSA-69166 8.623409e-01 0.064 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.623409e-01 0.064 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.623409e-01 0.064 0 0
Physiological factors R-HSA-5578768 8.623409e-01 0.064 1 1
HDL assembly R-HSA-8963896 8.623409e-01 0.064 0 0
P2Y receptors R-HSA-417957 8.623409e-01 0.064 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.623409e-01 0.064 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.639571e-01 0.064 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.642178e-01 0.063 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.642178e-01 0.063 0 0
IRE1alpha activates chaperones R-HSA-381070 8.652193e-01 0.063 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.653440e-01 0.063 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.653440e-01 0.063 0 0
ESR-mediated signaling R-HSA-8939211 8.658623e-01 0.063 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.668166e-01 0.062 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 8.668166e-01 0.062 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.668166e-01 0.062 0 0
TRP channels R-HSA-3295583 8.668166e-01 0.062 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.670077e-01 0.062 0 0
Signaling by WNT R-HSA-195721 8.686479e-01 0.061 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.718350e-01 0.060 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.718350e-01 0.060 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.722210e-01 0.059 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.722210e-01 0.059 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.723878e-01 0.059 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.727178e-01 0.059 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 8.727880e-01 0.059 0 0
Aquaporin-mediated transport R-HSA-445717 8.754009e-01 0.058 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.767087e-01 0.057 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.767087e-01 0.057 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.767087e-01 0.057 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.767087e-01 0.057 0 0
Protein lipoylation R-HSA-9857492 8.767087e-01 0.057 0 0
Translesion synthesis by REV1 R-HSA-110312 8.767087e-01 0.057 0 0
Signaling by Activin R-HSA-1502540 8.767087e-01 0.057 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.767087e-01 0.057 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.767087e-01 0.057 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.767087e-01 0.057 0 0
p38MAPK events R-HSA-171007 8.767087e-01 0.057 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.767087e-01 0.057 0 0
Protein methylation R-HSA-8876725 8.767087e-01 0.057 0 0
Cristae formation R-HSA-8949613 8.778183e-01 0.057 0 0
Signaling by BMP R-HSA-201451 8.778183e-01 0.057 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.785245e-01 0.056 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.798848e-01 0.056 0 0
Ca2+ pathway R-HSA-4086398 8.798848e-01 0.056 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.805086e-01 0.055 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.810531e-01 0.055 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.810531e-01 0.055 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.813037e-01 0.055 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.813037e-01 0.055 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.828690e-01 0.054 0 0
Collagen formation R-HSA-1474290 8.843935e-01 0.053 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.843935e-01 0.053 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.846137e-01 0.053 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.879751e-01 0.052 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.879751e-01 0.052 0 0
Translesion synthesis by POLI R-HSA-5656121 8.895777e-01 0.051 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.895777e-01 0.051 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.895777e-01 0.051 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.895777e-01 0.051 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.895777e-01 0.051 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.895777e-01 0.051 0 0
Killing mechanisms R-HSA-9664420 8.895777e-01 0.051 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.895777e-01 0.051 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.895777e-01 0.051 0 0
Attenuation phase R-HSA-3371568 8.896760e-01 0.051 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.896760e-01 0.051 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.899507e-01 0.051 0 0
Host Interactions of HIV factors R-HSA-162909 8.916948e-01 0.050 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.930804e-01 0.049 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.955785e-01 0.048 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.956907e-01 0.048 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.958722e-01 0.048 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.973437e-01 0.047 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.973437e-01 0.047 0 0
Glucagon-type ligand receptors R-HSA-420092 8.973437e-01 0.047 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.011040e-01 0.045 0 0
Translesion synthesis by POLK R-HSA-5655862 9.011040e-01 0.045 0 0
Glycine degradation R-HSA-6783984 9.011040e-01 0.045 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.011040e-01 0.045 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.011040e-01 0.045 0 0
Coenzyme A biosynthesis R-HSA-196783 9.011040e-01 0.045 0 0
Passive transport by Aquaporins R-HSA-432047 9.011040e-01 0.045 0 0
Synthesis of PG R-HSA-1483148 9.011040e-01 0.045 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.011040e-01 0.045 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.011040e-01 0.045 0 0
Post NMDA receptor activation events R-HSA-438064 9.025778e-01 0.045 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.025778e-01 0.045 0 0
Cellular response to hypoxia R-HSA-1234174 9.030131e-01 0.044 0 0
HCMV Early Events R-HSA-9609690 9.037810e-01 0.044 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.052591e-01 0.043 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.052591e-01 0.043 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.052591e-01 0.043 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.059779e-01 0.043 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.059779e-01 0.043 0 0
Translation initiation complex formation R-HSA-72649 9.091495e-01 0.041 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.091495e-01 0.041 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.091495e-01 0.041 0 0
Glucose metabolism R-HSA-70326 9.100831e-01 0.041 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.103863e-01 0.041 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.114278e-01 0.040 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.114278e-01 0.040 0 0
Glycogen storage diseases R-HSA-3229121 9.114278e-01 0.040 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 9.114278e-01 0.040 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.114278e-01 0.040 0 0
Catecholamine biosynthesis R-HSA-209905 9.114278e-01 0.040 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.114278e-01 0.040 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.122789e-01 0.040 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.122789e-01 0.040 0 0
Depyrimidination R-HSA-73928 9.122789e-01 0.040 0 0
Ca-dependent events R-HSA-111996 9.122789e-01 0.040 0 0
HCMV Late Events R-HSA-9610379 9.125106e-01 0.040 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.191512e-01 0.037 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.192375e-01 0.037 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.192375e-01 0.037 0 0
Ephrin signaling R-HSA-3928664 9.206745e-01 0.036 0 0
GAB1 signalosome R-HSA-180292 9.206745e-01 0.036 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.206745e-01 0.036 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.206745e-01 0.036 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.206745e-01 0.036 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.206745e-01 0.036 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.206745e-01 0.036 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.206745e-01 0.036 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 9.206745e-01 0.036 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.210419e-01 0.036 0 0
DNA strand elongation R-HSA-69190 9.212449e-01 0.036 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.212449e-01 0.036 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.212449e-01 0.036 0 0
tRNA processing R-HSA-72306 9.240839e-01 0.034 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.249174e-01 0.034 0 0
Translesion Synthesis by POLH R-HSA-110320 9.289563e-01 0.032 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.289563e-01 0.032 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.289563e-01 0.032 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.289563e-01 0.032 0 0
Diseases of hemostasis R-HSA-9671793 9.289563e-01 0.032 0 0
Maturation of nucleoprotein R-HSA-9694631 9.289563e-01 0.032 0 0
Other interleukin signaling R-HSA-449836 9.289563e-01 0.032 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.289563e-01 0.032 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.299484e-01 0.032 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.305900e-01 0.031 0 0
DAG and IP3 signaling R-HSA-1489509 9.305900e-01 0.031 0 0
Signaling by Insulin receptor R-HSA-74752 9.309902e-01 0.031 0 0
Protein folding R-HSA-391251 9.309902e-01 0.031 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.315181e-01 0.031 0 0
Interleukin-1 family signaling R-HSA-446652 9.327565e-01 0.030 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.336411e-01 0.030 0 0
Striated Muscle Contraction R-HSA-390522 9.341538e-01 0.030 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.341538e-01 0.030 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.341538e-01 0.030 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.358656e-01 0.029 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.358656e-01 0.029 0 0
Regulation of beta-cell development R-HSA-186712 9.362700e-01 0.029 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.363478e-01 0.029 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.363739e-01 0.029 0 0
Glycogen synthesis R-HSA-3322077 9.363739e-01 0.029 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.363739e-01 0.029 0 0
Pregnenolone biosynthesis R-HSA-196108 9.363739e-01 0.029 0 0
Signal transduction by L1 R-HSA-445144 9.363739e-01 0.029 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.386510e-01 0.027 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.386619e-01 0.027 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.386619e-01 0.027 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.397854e-01 0.027 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.407687e-01 0.027 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.416323e-01 0.026 0 0
Meiosis R-HSA-1500620 9.419617e-01 0.026 0 0
Lagging Strand Synthesis R-HSA-69186 9.430174e-01 0.025 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.430174e-01 0.025 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.430174e-01 0.025 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.448857e-01 0.025 0 0
PERK regulates gene expression R-HSA-381042 9.450396e-01 0.025 0 0
GPER1 signaling R-HSA-9634597 9.453223e-01 0.024 0 0
SARS-CoV-1-host interactions R-HSA-9692914 9.463730e-01 0.024 0 0
Signaling by ERBB4 R-HSA-1236394 9.464155e-01 0.024 0 0
Phospholipid metabolism R-HSA-1483257 9.476694e-01 0.023 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.489676e-01 0.023 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.489676e-01 0.023 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.489676e-01 0.023 0 0
Glutathione synthesis and recycling R-HSA-174403 9.489676e-01 0.023 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.489676e-01 0.023 0 0
DNA Damage Bypass R-HSA-73893 9.495487e-01 0.022 0 0
HSF1 activation R-HSA-3371511 9.498176e-01 0.022 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.498176e-01 0.022 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.498176e-01 0.022 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.524235e-01 0.021 0 0
Degradation of AXIN R-HSA-4641257 9.541974e-01 0.020 0 0
Cleavage of the damaged purine R-HSA-110331 9.541974e-01 0.020 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.542968e-01 0.020 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.542968e-01 0.020 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.542968e-01 0.020 0 0
Ethanol oxidation R-HSA-71384 9.542968e-01 0.020 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.542968e-01 0.020 0 0
Cellular hexose transport R-HSA-189200 9.542968e-01 0.020 0 0
LDL clearance R-HSA-8964038 9.542968e-01 0.020 0 0
Signaling by FGFR R-HSA-190236 9.547279e-01 0.020 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.549742e-01 0.020 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.555264e-01 0.020 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.558257e-01 0.020 0 0
Potential therapeutics for SARS R-HSA-9679191 9.569748e-01 0.019 0 0
Interferon Signaling R-HSA-913531 9.570320e-01 0.019 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.571028e-01 0.019 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.571028e-01 0.019 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.580836e-01 0.019 0 0
Depurination R-HSA-73927 9.582100e-01 0.019 0 0
Biofilm formation R-HSA-9931953 9.582100e-01 0.019 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.590698e-01 0.018 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.590698e-01 0.018 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.590698e-01 0.018 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.590698e-01 0.018 0 0
Formation of the ureteric bud R-HSA-9830674 9.590698e-01 0.018 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.604694e-01 0.018 0 0
Neurotransmitter release cycle R-HSA-112310 9.606118e-01 0.017 0 0
Stabilization of p53 R-HSA-69541 9.618844e-01 0.017 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.618844e-01 0.017 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.619657e-01 0.017 0 0
HCMV Infection R-HSA-9609646 9.620929e-01 0.017 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.623206e-01 0.017 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.623206e-01 0.017 0 0
Interleukin-1 signaling R-HSA-9020702 9.624326e-01 0.017 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.633445e-01 0.016 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.633445e-01 0.016 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.633445e-01 0.016 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.633445e-01 0.016 0 0
Interleukin-6 family signaling R-HSA-6783589 9.633445e-01 0.016 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.635865e-01 0.016 0 0
Smooth Muscle Contraction R-HSA-445355 9.635865e-01 0.016 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.652474e-01 0.015 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.652474e-01 0.015 0 0
Generation of second messenger molecules R-HSA-202433 9.652474e-01 0.015 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.652474e-01 0.015 0 0
Formation of the cornified envelope R-HSA-6809371 9.667111e-01 0.015 0 0
G protein gated Potassium channels R-HSA-1296059 9.671730e-01 0.014 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.671730e-01 0.014 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.671730e-01 0.014 0 0
Tight junction interactions R-HSA-420029 9.671730e-01 0.014 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.671730e-01 0.014 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.671730e-01 0.014 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.671730e-01 0.014 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.683240e-01 0.014 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.683240e-01 0.014 0 0
Maturation of spike protein R-HSA-9694548 9.683240e-01 0.014 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.691389e-01 0.014 0 0
G alpha (z) signalling events R-HSA-418597 9.691389e-01 0.014 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.697056e-01 0.013 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.698200e-01 0.013 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.702351e-01 0.013 0 0
Influenza Infection R-HSA-168255 9.703243e-01 0.013 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.706019e-01 0.013 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.706019e-01 0.013 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.711373e-01 0.013 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.711373e-01 0.013 0 0
Intra-Golgi traffic R-HSA-6811438 9.711373e-01 0.013 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.711373e-01 0.013 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.716051e-01 0.013 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.716051e-01 0.013 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.736727e-01 0.012 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.736727e-01 0.012 0 0
Packaging Of Telomere Ends R-HSA-171306 9.736727e-01 0.012 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.736727e-01 0.012 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.736727e-01 0.012 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.736727e-01 0.012 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.736727e-01 0.012 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.736727e-01 0.012 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.736727e-01 0.012 0 0
GABA B receptor activation R-HSA-977444 9.737087e-01 0.012 0 0
Activation of GABAB receptors R-HSA-991365 9.737087e-01 0.012 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.737087e-01 0.012 0 0
Synthesis of PA R-HSA-1483166 9.738837e-01 0.011 0 0
ECM proteoglycans R-HSA-3000178 9.740193e-01 0.011 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.752626e-01 0.011 0 0
Cellular responses to stress R-HSA-2262752 9.752956e-01 0.011 0 0
Dual incision in TC-NER R-HSA-6782135 9.759881e-01 0.011 0 0
Synthesis of DNA R-HSA-69239 9.759973e-01 0.011 0 0
Defective pyroptosis R-HSA-9710421 9.760581e-01 0.011 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.760581e-01 0.011 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.764230e-01 0.010 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.764230e-01 0.010 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.764230e-01 0.010 0 0
Pyroptosis R-HSA-5620971 9.764230e-01 0.010 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.777514e-01 0.010 0 0
Triglyceride metabolism R-HSA-8979227 9.779305e-01 0.010 0 0
Leishmania phagocytosis R-HSA-9664417 9.779731e-01 0.010 0 0
Parasite infection R-HSA-9664407 9.779731e-01 0.010 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.779731e-01 0.010 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.782036e-01 0.010 0 0
Amine ligand-binding receptors R-HSA-375280 9.782036e-01 0.010 0 0
Telomere Maintenance R-HSA-157579 9.785410e-01 0.009 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.788861e-01 0.009 0 0
DNA methylation R-HSA-5334118 9.788861e-01 0.009 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.788861e-01 0.009 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.788861e-01 0.009 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.788861e-01 0.009 0 0
Platelet calcium homeostasis R-HSA-418360 9.788861e-01 0.009 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.792238e-01 0.009 0 0
Signaling by NOTCH4 R-HSA-9013694 9.794223e-01 0.009 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.794223e-01 0.009 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.797226e-01 0.009 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.797226e-01 0.009 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.801624e-01 0.009 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.809743e-01 0.008 0 0
Neurotransmitter clearance R-HSA-112311 9.810920e-01 0.008 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.810920e-01 0.008 0 0
PLC beta mediated events R-HSA-112043 9.813753e-01 0.008 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.816952e-01 0.008 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.819500e-01 0.008 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.819500e-01 0.008 0 0
SLC transporter disorders R-HSA-5619102 9.826872e-01 0.008 0 0
Mitochondrial protein import R-HSA-1268020 9.828989e-01 0.007 0 0
Cargo concentration in the ER R-HSA-5694530 9.830676e-01 0.007 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.835807e-01 0.007 0 0
Synthesis of PC R-HSA-1483191 9.835807e-01 0.007 0 0
Cellular responses to stimuli R-HSA-8953897 9.840412e-01 0.007 0 0
Base Excision Repair R-HSA-73884 9.840760e-01 0.007 0 0
Signaling by ROBO receptors R-HSA-376176 9.843977e-01 0.007 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.848368e-01 0.007 0 0
Interleukin-10 signaling R-HSA-6783783 9.849927e-01 0.007 0 0
Cellular response to starvation R-HSA-9711097 9.853571e-01 0.006 0 0
G-protein beta:gamma signalling R-HSA-397795 9.864213e-01 0.006 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.864213e-01 0.006 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.864213e-01 0.006 0 0
Gap junction trafficking and regulation R-HSA-157858 9.864235e-01 0.006 0 0
Integration of energy metabolism R-HSA-163685 9.865794e-01 0.006 0 0
Opioid Signalling R-HSA-111885 9.868738e-01 0.006 0 0
EPH-Ephrin signaling R-HSA-2682334 9.872806e-01 0.006 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.876591e-01 0.005 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.878403e-01 0.005 0 0
G-protein mediated events R-HSA-112040 9.888899e-01 0.005 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.890234e-01 0.005 0 0
Dual Incision in GG-NER R-HSA-5696400 9.891111e-01 0.005 0 0
eNOS activation R-HSA-203615 9.891111e-01 0.005 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.891111e-01 0.005 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.891111e-01 0.005 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.891111e-01 0.005 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.891111e-01 0.005 0 0
Hyaluronan metabolism R-HSA-2142845 9.891111e-01 0.005 0 0
Developmental Biology R-HSA-1266738 9.893203e-01 0.005 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.898100e-01 0.004 0 0
Orc1 removal from chromatin R-HSA-68949 9.898100e-01 0.004 0 0
Co-inhibition by PD-1 R-HSA-389948 9.902458e-01 0.004 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.902491e-01 0.004 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.902491e-01 0.004 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.902491e-01 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.902491e-01 0.004 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.907436e-01 0.004 0 0
Stimuli-sensing channels R-HSA-2672351 9.908454e-01 0.004 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.912683e-01 0.004 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.912683e-01 0.004 0 0
Glycosphingolipid transport R-HSA-9845576 9.912683e-01 0.004 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.912683e-01 0.004 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.912752e-01 0.004 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.914522e-01 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.914522e-01 0.004 0 0
Toll-like Receptor Cascades R-HSA-168898 9.917520e-01 0.004 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.918764e-01 0.004 0 0
TCR signaling R-HSA-202403 9.920903e-01 0.003 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.921810e-01 0.003 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.921810e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.921810e-01 0.003 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.922147e-01 0.003 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.929983e-01 0.003 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.937302e-01 0.003 0 0
Pentose phosphate pathway R-HSA-71336 9.937302e-01 0.003 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.941946e-01 0.003 0 0
Glycogen metabolism R-HSA-8982491 9.943857e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.943857e-01 0.002 0 0
Downstream TCR signaling R-HSA-202424 9.947972e-01 0.002 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.949727e-01 0.002 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.949727e-01 0.002 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.949727e-01 0.002 0 0
GABA receptor activation R-HSA-977443 9.953021e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9694635 9.954050e-01 0.002 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.954983e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9683701 9.954983e-01 0.002 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.955586e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.957988e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.957988e-01 0.002 0 0
DNA Replication R-HSA-69306 9.958477e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.959690e-01 0.002 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.963906e-01 0.002 0 0
Complex I biogenesis R-HSA-6799198 9.964965e-01 0.002 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.967680e-01 0.001 0 0
Gap junction trafficking R-HSA-190828 9.967680e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.967680e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.967680e-01 0.001 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.968703e-01 0.001 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.968703e-01 0.001 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.971060e-01 0.001 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.971060e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.971060e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.973248e-01 0.001 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.973477e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.976361e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.976797e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.977334e-01 0.001 0 0
Regulation of insulin secretion R-HSA-422356 9.977640e-01 0.001 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.978583e-01 0.001 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.978735e-01 0.001 0 0
Intraflagellar transport R-HSA-5620924 9.979224e-01 0.001 0 0
Co-stimulation by CD28 R-HSA-389356 9.979224e-01 0.001 0 0
Metal ion SLC transporters R-HSA-425410 9.979224e-01 0.001 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.979644e-01 0.001 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.981208e-01 0.001 0 0
Degradation of CDH1 R-HSA-9766229 9.981398e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.981398e-01 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.981398e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.981398e-01 0.001 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.982551e-01 0.001 0 0
Platelet degranulation R-HSA-114608 9.982667e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.984088e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.984088e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.984933e-01 0.001 0 0
Cellular response to chemical stress R-HSA-9711123 9.984960e-01 0.001 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.985086e-01 0.001 0 0
Meiotic recombination R-HSA-912446 9.985086e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.985086e-01 0.001 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.986123e-01 0.001 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.986123e-01 0.001 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.986646e-01 0.001 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.986956e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.987139e-01 0.001 0 0
Signaling by Interleukins R-HSA-449147 9.987253e-01 0.001 0 0
Neddylation R-HSA-8951664 9.987537e-01 0.001 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.989295e-01 0.000 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.989310e-01 0.000 0 0
Protein ubiquitination R-HSA-8852135 9.989312e-01 0.000 0 0
Interferon gamma signaling R-HSA-877300 9.989532e-01 0.000 0 0
Platelet homeostasis R-HSA-418346 9.989735e-01 0.000 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.990027e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.990257e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.990257e-01 0.000 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.990354e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.990415e-01 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.991121e-01 0.000 0 0
Ion homeostasis R-HSA-5578775 9.991418e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.991418e-01 0.000 0 0
PCP/CE pathway R-HSA-4086400 9.992081e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.992081e-01 0.000 0 0
Regulation of CDH1 Function R-HSA-9764561 9.992316e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.992316e-01 0.000 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.992630e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.992836e-01 0.000 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.993120e-01 0.000 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.993165e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.993840e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.993886e-01 0.000 0 0
SARS-CoV Infections R-HSA-9679506 9.994429e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.994485e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.994485e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.995062e-01 0.000 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.995093e-01 0.000 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.995579e-01 0.000 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.995749e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.996061e-01 0.000 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.996061e-01 0.000 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.996094e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.996116e-01 0.000 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.996178e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.996457e-01 0.000 0 0
Ion transport by P-type ATPases R-HSA-936837 9.996457e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.996457e-01 0.000 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.996828e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.997025e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.997106e-01 0.000 0 0
Peptide chain elongation R-HSA-156902 9.997385e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.997385e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.997457e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997457e-01 0.000 0 0
Kidney development R-HSA-9830369 9.997457e-01 0.000 0 0
Transmission across Chemical Synapses R-HSA-112315 9.997524e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.997723e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.997778e-01 0.000 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.998032e-01 0.000 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.998071e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.998211e-01 0.000 0 0
Protein localization R-HSA-9609507 9.998347e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998366e-01 0.000 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.998426e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.998654e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.998654e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.998716e-01 0.000 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.998913e-01 0.000 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.998950e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998951e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.998951e-01 0.000 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.998953e-01 0.000 0 0
Eukaryotic Translation Termination R-HSA-72764 9.998953e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998974e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999054e-01 0.000 0 0
Interleukin-12 signaling R-HSA-9020591 9.999061e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999085e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.999229e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999247e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.999247e-01 0.000 0 0
Developmental Cell Lineages R-HSA-9734767 9.999271e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999326e-01 0.000 0 0
Adaptive Immune System R-HSA-1280218 9.999343e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.999372e-01 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 9.999433e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.999460e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999460e-01 0.000 0 0
Viral mRNA Translation R-HSA-192823 9.999538e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.999722e-01 0.000 0 0
Interleukin-12 family signaling R-HSA-447115 9.999751e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999775e-01 0.000 0 0
Neuronal System R-HSA-112316 9.999844e-01 0.000 0 0
Hemostasis R-HSA-109582 9.999883e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999902e-01 0.000 0 0
rRNA processing R-HSA-72312 9.999904e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999908e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.999911e-01 0.000 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.999918e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999918e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999926e-01 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 9.999941e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999941e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999947e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999960e-01 0.000 0 0
Muscle contraction R-HSA-397014 9.999964e-01 0.000 1 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999969e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999983e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999984e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.999985e-01 0.000 1 0
Sensory perception of taste R-HSA-9717189 9.999985e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999985e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999988e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999989e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999989e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999992e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999993e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999995e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999996e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999996e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999997e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999997e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999998e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000e+00 0.000 1 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Neutrophil degranulation R-HSA-6798695 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Translation R-HSA-72766 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Immune System R-HSA-168256 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 -0.000 1 0
Disease R-HSA-1643685 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.862972e-08 7.052 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.278026e-08 7.369 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.129686e-08 7.213 0 0
Gene expression (Transcription) R-HSA-74160 1.066885e-07 6.972 1 0
Chromatin organization R-HSA-4839726 8.055187e-08 7.094 0 0
mRNA 3'-end processing R-HSA-72187 7.201741e-07 6.143 0 0
Chromatin modifying enzymes R-HSA-3247509 1.247089e-06 5.904 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.830990e-06 5.737 0 0
Signaling by Hippo R-HSA-2028269 2.450145e-06 5.611 0 0
RNA Polymerase II Transcription R-HSA-73857 3.254288e-06 5.488 1 0
MITF-M-dependent gene expression R-HSA-9856651 4.068485e-06 5.391 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.043595e-06 5.297 1 1
RNA Polymerase II Transcription Termination R-HSA-73856 5.265635e-06 5.279 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.987835e-06 5.156 0 0
Activation of BH3-only proteins R-HSA-114452 1.019548e-05 4.992 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.897058e-05 4.722 0 0
mRNA Splicing R-HSA-72172 2.069236e-05 4.684 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.006827e-05 4.522 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.286608e-05 4.483 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.768862e-05 4.169 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.829045e-05 4.106 0 0
Formation of axial mesoderm R-HSA-9796292 8.609287e-05 4.065 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.609287e-05 4.065 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.197429e-04 3.922 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.824135e-04 3.739 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.808529e-04 3.743 1 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.172182e-04 3.663 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.024087e-04 3.519 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.071820e-04 3.513 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.185526e-04 3.497 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.948079e-04 3.404 1 1
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.368903e-04 3.360 0 0
Adipogenesis R-HSA-9843745 4.829313e-04 3.316 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.196549e-04 3.284 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.265152e-04 3.279 0 0
Generic Transcription Pathway R-HSA-212436 6.086747e-04 3.216 1 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.209265e-04 3.142 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.995756e-04 3.097 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.995756e-04 3.097 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.995756e-04 3.097 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.462588e-04 3.072 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 9.801463e-04 3.009 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 9.801463e-04 3.009 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.783598e-04 3.010 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 9.878107e-04 3.005 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.062390e-03 2.974 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.062390e-03 2.974 0 0
TGFBR3 expression R-HSA-9839394 1.062390e-03 2.974 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 9.878107e-04 3.005 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.402561e-03 2.853 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.441706e-03 2.841 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.441706e-03 2.841 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.482939e-03 2.829 0 0
Cell Cycle R-HSA-1640170 1.547623e-03 2.810 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.666975e-03 2.778 0 0
Apoptotic execution phase R-HSA-75153 1.691379e-03 2.772 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.731207e-03 2.762 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.731207e-03 2.762 0 0
Apoptosis R-HSA-109581 1.805979e-03 2.743 0 0
HATs acetylate histones R-HSA-3214847 1.825635e-03 2.739 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.927452e-03 2.715 0 0
Cellular Senescence R-HSA-2559583 1.902450e-03 2.721 0 0
Heme signaling R-HSA-9707616 1.927452e-03 2.715 0 0
Signaling by LTK R-HSA-9842663 2.050120e-03 2.688 0 0
Notch-HLH transcription pathway R-HSA-350054 2.179535e-03 2.662 0 0
Nuclear import of Rev protein R-HSA-180746 2.066013e-03 2.685 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.451095e-03 2.611 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.614883e-03 2.583 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.618768e-03 2.582 0 0
Cell Cycle, Mitotic R-HSA-69278 2.875337e-03 2.541 0 0
Regulation of TP53 Activity R-HSA-5633007 3.066209e-03 2.513 1 0
Epigenetic regulation of gene expression R-HSA-212165 3.246347e-03 2.489 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.393304e-03 2.469 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.638892e-03 2.439 1 1
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.196938e-03 2.377 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.222918e-03 2.374 0 0
Signaling by ALK in cancer R-HSA-9700206 4.222918e-03 2.374 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.961666e-03 2.402 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.286686e-03 2.368 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.492052e-03 2.348 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.602739e-03 2.337 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.813204e-03 2.318 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.822200e-03 2.317 0 0
Gastrulation R-HSA-9758941 5.233428e-03 2.281 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.322687e-03 2.274 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.322687e-03 2.274 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.502465e-03 2.259 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.525933e-03 2.258 0 0
Signaling by NOTCH3 R-HSA-9012852 5.682318e-03 2.245 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.821014e-03 2.235 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.997839e-03 2.222 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.127852e-03 2.213 0 0
NGF-stimulated transcription R-HSA-9031628 6.356965e-03 2.197 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.459534e-03 2.190 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.843624e-03 2.165 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.362471e-03 2.133 0 0
Disorders of Developmental Biology R-HSA-9675151 7.524017e-03 2.124 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 7.909019e-03 2.102 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 7.909019e-03 2.102 0 0
MECP2 regulates transcription factors R-HSA-9022707 9.047965e-03 2.043 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 9.047965e-03 2.043 0 0
Signaling by NTRKs R-HSA-166520 9.247341e-03 2.034 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 9.581843e-03 2.019 0 0
Pervasive developmental disorders R-HSA-9005895 9.978367e-03 2.001 0 0
Disorders of Nervous System Development R-HSA-9697154 9.978367e-03 2.001 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 9.978367e-03 2.001 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.119181e-02 1.951 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.109097e-02 1.955 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.097001e-02 1.960 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.138415e-02 1.944 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.150203e-02 1.939 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.166337e-02 1.933 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.289018e-02 1.890 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.245187e-02 1.905 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.267224e-02 1.897 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.267224e-02 1.897 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.267279e-02 1.897 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.311987e-02 1.882 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.267224e-02 1.897 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.245187e-02 1.905 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.311987e-02 1.882 0 0
Inositol phosphate metabolism R-HSA-1483249 1.293506e-02 1.888 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.313300e-02 1.882 0 0
Signaling by ALK R-HSA-201556 1.313300e-02 1.882 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.376204e-02 1.861 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.457758e-02 1.836 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.457758e-02 1.836 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.581931e-02 1.801 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.581931e-02 1.801 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.691729e-02 1.772 1 0
Formation of definitive endoderm R-HSA-9823730 1.646617e-02 1.783 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.658005e-02 1.780 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.679682e-02 1.775 0 0
Programmed Cell Death R-HSA-5357801 1.659858e-02 1.780 0 0
NRAGE signals death through JNK R-HSA-193648 1.578810e-02 1.802 0 0
Circadian clock R-HSA-9909396 1.830253e-02 1.737 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.837648e-02 1.736 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.931090e-02 1.714 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.931090e-02 1.714 0 0
Signaling by NOTCH1 R-HSA-1980143 2.001305e-02 1.699 0 0
Mitochondrial biogenesis R-HSA-1592230 2.101134e-02 1.678 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.147416e-02 1.668 0 0
Signal attenuation R-HSA-74749 2.147416e-02 1.668 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.358369e-02 1.627 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.329275e-02 1.633 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.329275e-02 1.633 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.329275e-02 1.633 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.329275e-02 1.633 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.329275e-02 1.633 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.455964e-02 1.610 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.424791e-02 1.615 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.237321e-02 1.650 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.569209e-02 1.590 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.571354e-02 1.590 0 0
Metabolism of RNA R-HSA-8953854 2.606012e-02 1.584 0 0
Cellular response to heat stress R-HSA-3371556 2.710418e-02 1.567 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.720158e-02 1.565 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.720158e-02 1.565 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.763828e-02 1.558 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.789450e-02 1.554 0 0
tRNA processing in the nucleus R-HSA-6784531 2.789450e-02 1.554 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.824754e-02 1.549 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.824754e-02 1.549 0 0
Membrane Trafficking R-HSA-199991 2.869169e-02 1.542 0 0
Cell Cycle Checkpoints R-HSA-69620 2.882942e-02 1.540 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.913847e-02 1.536 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.345726e-02 1.476 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.030908e-02 1.518 0 0
Signaling by NOTCH R-HSA-157118 3.254333e-02 1.488 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.030908e-02 1.518 0 0
Signaling by TGFBR3 R-HSA-9839373 3.221275e-02 1.492 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.281626e-02 1.484 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.367684e-02 1.473 0 0
FOXO-mediated transcription R-HSA-9614085 3.478309e-02 1.459 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.546826e-02 1.450 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.655787e-02 1.437 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.655787e-02 1.437 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.666276e-02 1.436 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.712440e-02 1.430 0 0
M Phase R-HSA-68886 3.801096e-02 1.420 0 0
HDMs demethylate histones R-HSA-3214842 4.050927e-02 1.392 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.144979e-02 1.382 0 0
SOS-mediated signalling R-HSA-112412 4.734757e-02 1.325 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.734757e-02 1.325 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.101948e-02 1.387 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.594421e-02 1.338 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.594421e-02 1.338 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.437137e-02 1.353 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.276943e-02 1.369 0 0
Regulation of TP53 Expression R-HSA-6804754 4.144979e-02 1.382 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.101948e-02 1.387 0 0
Regulation of beta-cell development R-HSA-186712 4.643131e-02 1.333 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.734757e-02 1.325 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.188818e-02 1.378 0 0
HIV Life Cycle R-HSA-162587 4.690036e-02 1.329 0 0
Metabolism of non-coding RNA R-HSA-194441 4.643131e-02 1.333 0 0
snRNP Assembly R-HSA-191859 4.643131e-02 1.333 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.081174e-02 1.294 0 0
MTOR signalling R-HSA-165159 5.081174e-02 1.294 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.181108e-02 1.286 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.820466e-02 1.235 0 0
Type I hemidesmosome assembly R-HSA-446107 5.951639e-02 1.225 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 5.951639e-02 1.225 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 5.951639e-02 1.225 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 5.951639e-02 1.225 0 0
RUNX2 regulates bone development R-HSA-8941326 6.046148e-02 1.219 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.204207e-02 1.207 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.517337e-02 1.186 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.517337e-02 1.186 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 7.687219e-02 1.114 0 0
Erythropoietin activates RAS R-HSA-9027284 6.802962e-02 1.167 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.802962e-02 1.167 0 0
Phosphorylation of the APC/C R-HSA-176412 7.865248e-02 1.104 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 7.282673e-02 1.138 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.508317e-02 1.124 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.294065e-02 1.137 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 6.966395e-02 1.157 0 0
UCH proteinases R-HSA-5689603 7.922751e-02 1.101 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 6.803764e-02 1.167 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.299293e-02 1.137 0 0
Mitotic Anaphase R-HSA-68882 6.759671e-02 1.170 0 0
S Phase R-HSA-69242 8.036944e-02 1.095 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.019016e-02 1.154 0 0
mTORC1-mediated signalling R-HSA-166208 7.667531e-02 1.115 0 0
HDACs deacetylate histones R-HSA-3214815 7.028571e-02 1.153 0 0
Unwinding of DNA R-HSA-176974 7.299293e-02 1.137 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.802962e-02 1.167 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.802962e-02 1.167 0 0
Signaling by EGFR R-HSA-177929 7.574161e-02 1.121 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.803764e-02 1.167 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.803764e-02 1.167 0 0
Mitotic Prophase R-HSA-68875 7.747111e-02 1.111 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.145009e-02 1.089 0 0
PTEN Regulation R-HSA-6807070 8.211358e-02 1.086 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 8.414523e-02 1.075 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 8.414523e-02 1.075 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 8.414523e-02 1.075 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.452289e-02 1.073 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.587509e-02 1.066 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 8.587509e-02 1.066 0 0
Regulation of CDH11 function R-HSA-9762292 8.769300e-02 1.057 0 0
DNA strand elongation R-HSA-69190 8.770605e-02 1.057 0 0
Cell junction organization R-HSA-446728 8.800620e-02 1.055 0 0
G alpha (12/13) signalling events R-HSA-416482 8.957356e-02 1.048 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.004766e-02 1.046 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 9.004766e-02 1.046 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 9.004766e-02 1.046 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.088499e-01 0.963 0 0
IRS activation R-HSA-74713 1.088499e-01 0.963 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.088499e-01 0.963 0 0
G2 Phase R-HSA-68911 1.088499e-01 0.963 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.088499e-01 0.963 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.035231e-01 0.985 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.035231e-01 0.985 0 0
Deadenylation of mRNA R-HSA-429947 9.562537e-02 1.019 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.000898e-01 1.000 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.021843e-01 0.991 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.025938e-01 0.989 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.025938e-01 0.989 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.025938e-01 0.989 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 1.035231e-01 0.985 0 0
Synthesis of DNA R-HSA-69239 1.021902e-01 0.991 0 0
Mitotic Prometaphase R-HSA-68877 9.199048e-02 1.036 0 0
Nuclear RNA decay R-HSA-9930044 9.618524e-02 1.017 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.088499e-01 0.963 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.007041e-01 0.997 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.111416e-01 0.954 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 1.021843e-01 0.991 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.562537e-02 1.019 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.050849e-01 0.978 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 9.879453e-02 1.005 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.131950e-01 0.946 0 0
G2/M Checkpoints R-HSA-69481 1.119682e-01 0.951 0 0
Cardiogenesis R-HSA-9733709 9.618524e-02 1.017 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.033225e-01 0.986 0 0
NrCAM interactions R-HSA-447038 1.088499e-01 0.963 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.093061e-01 0.961 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 1.143960e-01 0.942 0 0
Mismatch Repair R-HSA-5358508 1.150268e-01 0.939 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.150268e-01 0.939 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.150268e-01 0.939 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.150268e-01 0.939 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.150268e-01 0.939 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.150268e-01 0.939 0 0
Myogenesis R-HSA-525793 1.167168e-01 0.933 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.167168e-01 0.933 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.478393e-01 0.830 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.478393e-01 0.830 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.478393e-01 0.830 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.478393e-01 0.830 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.478393e-01 0.830 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.478393e-01 0.830 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.478393e-01 0.830 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.478393e-01 0.830 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.351700e-01 0.869 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.203835e-01 0.919 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.203835e-01 0.919 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.381709e-01 0.860 0 0
Repression of WNT target genes R-HSA-4641265 1.381709e-01 0.860 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.381709e-01 0.860 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.381709e-01 0.860 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.381709e-01 0.860 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.381709e-01 0.860 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.381709e-01 0.860 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.567802e-01 0.805 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.285359e-01 0.891 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.285359e-01 0.891 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.573812e-01 0.803 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.280212e-01 0.893 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.280212e-01 0.893 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.398032e-01 0.854 0 0
HIV elongation arrest and recovery R-HSA-167287 1.398032e-01 0.854 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.398032e-01 0.854 0 0
G1/S-Specific Transcription R-HSA-69205 1.342082e-01 0.872 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.461662e-01 0.835 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.387354e-01 0.858 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.387354e-01 0.858 0 0
MET activates RAS signaling R-HSA-8851805 1.381709e-01 0.860 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.461662e-01 0.835 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.461662e-01 0.835 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.319233e-01 0.880 0 0
Signaling by RAS mutants R-HSA-6802949 1.461662e-01 0.835 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.446836e-01 0.840 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.203835e-01 0.919 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.483063e-01 0.829 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.319233e-01 0.880 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.478393e-01 0.830 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.520392e-01 0.818 0 0
Oncogene Induced Senescence R-HSA-2559585 1.241078e-01 0.906 0 0
Cell-Cell communication R-HSA-1500931 1.373598e-01 0.862 0 0
RET signaling R-HSA-8853659 1.342082e-01 0.872 0 0
Rap1 signalling R-HSA-392517 1.285359e-01 0.891 0 0
TBC/RABGAPs R-HSA-8854214 1.187628e-01 0.925 0 0
Developmental Biology R-HSA-1266738 1.519643e-01 0.818 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.351700e-01 0.869 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.440204e-01 0.842 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.542348e-01 0.812 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.526462e-01 0.816 0 0
Signal Transduction R-HSA-162582 1.190650e-01 0.924 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.492056e-01 0.826 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.280212e-01 0.893 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.567802e-01 0.805 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.547877e-01 0.810 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.573812e-01 0.803 0 0
Transcription of the HIV genome R-HSA-167172 1.605303e-01 0.794 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.605303e-01 0.794 0 0
CREB phosphorylation R-HSA-199920 1.627117e-01 0.789 0 0
Gene Silencing by RNA R-HSA-211000 1.643310e-01 0.784 0 0
Activation of the pre-replicative complex R-HSA-68962 1.647040e-01 0.783 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.647040e-01 0.783 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.648845e-01 0.783 0 0
Deubiquitination R-HSA-5688426 1.654423e-01 0.781 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.691119e-01 0.772 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 1.714426e-01 0.766 0 0
Rab regulation of trafficking R-HSA-9007101 1.719695e-01 0.765 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.726256e-01 0.763 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.726256e-01 0.763 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.754852e-01 0.756 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.761067e-01 0.754 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 1.782062e-01 0.749 0 0
Interleukin-2 family signaling R-HSA-451927 1.782062e-01 0.749 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.133546e-01 0.671 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.133546e-01 0.671 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.133546e-01 0.671 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.133546e-01 0.671 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.133546e-01 0.671 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.738365e-01 0.563 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.738365e-01 0.563 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.738365e-01 0.563 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.738365e-01 0.563 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.738365e-01 0.563 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.738365e-01 0.563 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.738365e-01 0.563 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.738365e-01 0.563 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.738365e-01 0.563 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.738365e-01 0.563 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.738365e-01 0.563 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.738365e-01 0.563 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.738365e-01 0.563 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.911319e-01 0.719 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.911319e-01 0.719 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.911319e-01 0.719 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.911319e-01 0.719 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.296716e-01 0.482 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 3.296716e-01 0.482 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.296716e-01 0.482 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 3.296716e-01 0.482 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.296716e-01 0.482 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.201333e-01 0.657 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.494587e-01 0.603 0 0
WNT mediated activation of DVL R-HSA-201688 2.494587e-01 0.603 0 0
ALK mutants bind TKIs R-HSA-9700645 2.494587e-01 0.603 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 3.812166e-01 0.419 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 3.812166e-01 0.419 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 3.812166e-01 0.419 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 3.812166e-01 0.419 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 3.812166e-01 0.419 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.812166e-01 0.419 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.960468e-01 0.708 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.960468e-01 0.708 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.788871e-01 0.555 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.788871e-01 0.555 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 2.788871e-01 0.555 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.165001e-01 0.665 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.165001e-01 0.665 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.082296e-01 0.511 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.082296e-01 0.511 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 3.082296e-01 0.511 0 0
Signaling by APC mutants R-HSA-4839744 3.082296e-01 0.511 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.082296e-01 0.511 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.082296e-01 0.511 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.082296e-01 0.511 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.288009e-01 0.368 0 0
Polymerase switching R-HSA-69091 3.660396e-01 0.436 0 0
Leading Strand Synthesis R-HSA-69109 3.660396e-01 0.436 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.660396e-01 0.436 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 4.727285e-01 0.325 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 4.727285e-01 0.325 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 4.727285e-01 0.325 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 4.727285e-01 0.325 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 4.727285e-01 0.325 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 4.727285e-01 0.325 0 0
Phosphorylation of Emi1 R-HSA-176417 4.727285e-01 0.325 0 0
Signaling by RNF43 mutants R-HSA-5340588 4.727285e-01 0.325 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 4.727285e-01 0.325 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 4.727285e-01 0.325 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 2.021304e-01 0.694 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.021304e-01 0.694 0 0
HIV Transcription Initiation R-HSA-167161 2.021304e-01 0.694 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 2.021304e-01 0.694 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.145097e-01 0.669 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.232226e-01 0.490 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 2.271408e-01 0.644 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.901444e-01 0.537 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.901444e-01 0.537 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.087567e-01 0.680 0 0
Lagging Strand Synthesis R-HSA-69186 3.448785e-01 0.462 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 3.448785e-01 0.462 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.200557e-01 0.657 0 0
Signaling by Erythropoietin R-HSA-9006335 3.078979e-01 0.512 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.078979e-01 0.512 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 2.530776e-01 0.597 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.663422e-01 0.575 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.664699e-01 0.436 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 3.664699e-01 0.436 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.664699e-01 0.436 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.664699e-01 0.436 0 0
Removal of the Flap Intermediate R-HSA-69166 4.218886e-01 0.375 0 0
Signaling by LTK in cancer R-HSA-9842640 5.132804e-01 0.290 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 5.132804e-01 0.290 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.132804e-01 0.290 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.241866e-01 0.489 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 4.488539e-01 0.348 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.488539e-01 0.348 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.092197e-01 0.388 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.092197e-01 0.388 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 4.302717e-01 0.366 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 5.507157e-01 0.259 0 0
Recycling of eIF2:GDP R-HSA-72731 5.507157e-01 0.259 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.239511e-01 0.490 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.421659e-01 0.466 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.421659e-01 0.466 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.627937e-01 0.440 0 0
PPARA activates gene expression R-HSA-1989781 2.291875e-01 0.640 0 0
Translation initiation complex formation R-HSA-72649 3.768448e-01 0.424 0 0
Centrosome maturation R-HSA-380287 3.474938e-01 0.459 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.005586e-01 0.301 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.806423e-01 0.419 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.049597e-01 0.393 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.736896e-01 0.427 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.487899e-01 0.348 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.916060e-01 0.308 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.252141e-01 0.280 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.774284e-01 0.423 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.576394e-01 0.339 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.490337e-01 0.260 0 0
Late endosomal microautophagy R-HSA-9615710 5.306293e-01 0.275 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.238500e-01 0.281 0 0
DAP12 signaling R-HSA-2424491 5.494993e-01 0.260 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.383406e-01 0.269 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 5.445070e-01 0.264 0 0
Nucleotide Excision Repair R-HSA-5696398 2.324409e-01 0.634 0 0
HIV Transcription Elongation R-HSA-167169 3.241866e-01 0.489 0 0
G0 and Early G1 R-HSA-1538133 3.616125e-01 0.442 0 0
RAF activation R-HSA-5673000 2.334946e-01 0.632 0 0
HCMV Early Events R-HSA-9609690 3.625350e-01 0.441 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.320930e-01 0.364 0 0
mRNA Capping R-HSA-72086 5.306293e-01 0.275 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.071257e-01 0.684 0 0
G1/S Transition R-HSA-69206 4.444483e-01 0.352 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.460162e-01 0.609 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.241866e-01 0.489 0 0
Integrin signaling R-HSA-354192 3.795344e-01 0.421 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 5.507157e-01 0.259 0 0
Aggrephagy R-HSA-9646399 3.241866e-01 0.489 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.494993e-01 0.260 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.210665e-01 0.655 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.917594e-01 0.535 0 0
MAP2K and MAPK activation R-HSA-5674135 2.021304e-01 0.694 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.078979e-01 0.512 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.329739e-01 0.364 0 0
Meiotic synapsis R-HSA-1221632 5.383406e-01 0.269 0 0
G1 Phase R-HSA-69236 2.400036e-01 0.620 0 0
Cyclin D associated events in G1 R-HSA-69231 2.400036e-01 0.620 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.373694e-01 0.625 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.178652e-01 0.379 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.257549e-01 0.487 0 0
PI3K/AKT activation R-HSA-198203 2.788871e-01 0.555 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.788871e-01 0.555 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 4.727285e-01 0.325 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.087018e-01 0.510 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.750931e-01 0.323 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.667273e-01 0.574 0 0
Polo-like kinase mediated events R-HSA-156711 5.490337e-01 0.260 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.881834e-01 0.311 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.974027e-01 0.401 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.503548e-01 0.346 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.000477e-01 0.699 0 0
Signaling by ERBB2 R-HSA-1227986 3.042196e-01 0.517 0 0
Gap junction degradation R-HSA-190873 2.494587e-01 0.603 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.494587e-01 0.603 0 0
Regulation of gap junction activity R-HSA-191650 3.812166e-01 0.419 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 4.288009e-01 0.368 0 0
Activation of RAC1 R-HSA-428540 3.373256e-01 0.472 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.660396e-01 0.436 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 4.727285e-01 0.325 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.315657e-01 0.635 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.795344e-01 0.421 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.579963e-01 0.588 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 5.507157e-01 0.259 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.507157e-01 0.259 0 0
Separation of Sister Chromatids R-HSA-2467813 2.136996e-01 0.670 0 0
Ephrin signaling R-HSA-3928664 5.490337e-01 0.260 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.200557e-01 0.657 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.007142e-01 0.522 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.494993e-01 0.260 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.078979e-01 0.512 0 0
IGF1R signaling cascade R-HSA-2428924 3.549523e-01 0.450 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.025666e-01 0.519 0 0
Signaling by WNT in cancer R-HSA-4791275 1.912125e-01 0.718 0 0
DNA Double Strand Break Response R-HSA-5693606 3.935170e-01 0.405 0 0
RNA Polymerase III Transcription R-HSA-74158 4.503548e-01 0.346 0 0
Signaling by WNT R-HSA-195721 2.630998e-01 0.580 0 0
PTK6 Expression R-HSA-8849473 1.911319e-01 0.719 0 0
Adrenoceptors R-HSA-390696 2.201333e-01 0.657 0 0
Formation of the posterior neural plate R-HSA-9832991 3.082296e-01 0.511 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.288009e-01 0.368 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.373256e-01 0.472 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.799893e-01 0.553 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.660396e-01 0.436 0 0
Killing mechanisms R-HSA-9664420 4.750931e-01 0.323 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.750931e-01 0.323 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.184686e-01 0.497 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.005586e-01 0.301 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.433967e-01 0.464 0 0
Neurexins and neuroligins R-HSA-6794361 2.087567e-01 0.680 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.677826e-01 0.434 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 3.942584e-01 0.404 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.167843e-01 0.499 0 0
Frs2-mediated activation R-HSA-170968 3.942584e-01 0.404 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.888695e-01 0.539 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.551253e-01 0.593 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.917594e-01 0.535 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.507157e-01 0.259 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.252141e-01 0.280 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.974027e-01 0.401 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.373256e-01 0.472 0 0
Recycling pathway of L1 R-HSA-437239 2.797764e-01 0.553 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.397522e-01 0.469 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.766180e-01 0.424 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.210665e-01 0.655 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.054254e-01 0.687 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.054254e-01 0.687 0 0
DNA Replication R-HSA-69306 5.014002e-01 0.300 0 0
Specification of the neural plate border R-HSA-9834899 3.015688e-01 0.521 0 0
Prolonged ERK activation events R-HSA-169893 4.750931e-01 0.323 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.783062e-01 0.320 0 0
Adherens junctions interactions R-HSA-418990 2.078281e-01 0.682 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.133546e-01 0.671 0 0
mRNA Editing: A to I Conversion R-HSA-75064 2.738365e-01 0.563 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.738365e-01 0.563 0 0
C6 deamination of adenosine R-HSA-75102 2.738365e-01 0.563 0 0
MET interacts with TNS proteins R-HSA-8875513 3.296716e-01 0.482 0 0
Formation of annular gap junctions R-HSA-196025 2.201333e-01 0.657 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.494587e-01 0.603 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.812166e-01 0.419 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.960468e-01 0.708 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.082296e-01 0.511 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 4.288009e-01 0.368 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.373256e-01 0.472 0 0
Signaling by AXIN mutants R-HSA-4839735 3.373256e-01 0.472 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.373256e-01 0.472 0 0
Pentose phosphate pathway disease R-HSA-6791465 4.727285e-01 0.325 0 0
Synthesis of PS R-HSA-1483101 4.727285e-01 0.325 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.942584e-01 0.404 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.302717e-01 0.366 0 0
Cell-cell junction organization R-HSA-421270 3.356260e-01 0.474 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.113238e-01 0.291 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.490337e-01 0.260 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.183820e-01 0.285 0 0
Orc1 removal from chromatin R-HSA-68949 5.238500e-01 0.281 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.849850e-01 0.415 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.799893e-01 0.553 0 0
Signalling to ERKs R-HSA-187687 4.328438e-01 0.364 0 0
Sensory processing of sound R-HSA-9659379 2.651744e-01 0.576 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.042196e-01 0.517 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 2.494587e-01 0.603 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.585619e-01 0.587 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.005586e-01 0.301 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.347729e-01 0.272 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.931212e-01 0.405 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.288009e-01 0.368 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.795344e-01 0.421 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.151832e-01 0.382 0 0
Long-term potentiation R-HSA-9620244 4.510464e-01 0.346 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.576394e-01 0.339 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.576394e-01 0.339 0 0
Vesicle-mediated transport R-HSA-5653656 3.844579e-01 0.415 0 0
DCC mediated attractive signaling R-HSA-418885 1.960468e-01 0.708 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.490337e-01 0.260 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.044082e-01 0.297 0 0
HIV Infection R-HSA-162906 1.948943e-01 0.710 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 3.812166e-01 0.419 0 0
Formation of intermediate mesoderm R-HSA-9761174 2.788871e-01 0.555 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.883540e-01 0.725 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.727285e-01 0.325 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.507157e-01 0.259 0 0
Signaling by MET R-HSA-6806834 4.070661e-01 0.390 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.130574e-01 0.504 0 0
Cellular responses to stress R-HSA-2262752 3.449249e-01 0.462 0 0
Post NMDA receptor activation events R-HSA-438064 5.016401e-01 0.300 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.493575e-01 0.260 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.183820e-01 0.285 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.183820e-01 0.285 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.187103e-01 0.285 0 0
Interleukin-15 signaling R-HSA-8983432 3.660396e-01 0.436 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.329739e-01 0.364 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.344989e-01 0.630 1 1
MAP kinase activation R-HSA-450294 4.745208e-01 0.324 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.553712e-01 0.449 0 0
Intracellular oxygen transport R-HSA-8981607 3.296716e-01 0.482 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.296716e-01 0.482 0 0
NADE modulates death signalling R-HSA-205025 3.812166e-01 0.419 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.373256e-01 0.472 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.727285e-01 0.325 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 5.507157e-01 0.259 0 0
Ca2+ activated K+ channels R-HSA-1296052 5.507157e-01 0.259 0 0
VLDL clearance R-HSA-8964046 5.507157e-01 0.259 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.916060e-01 0.308 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.252141e-01 0.280 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.252141e-01 0.280 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.883540e-01 0.725 0 0
Protein hydroxylation R-HSA-9629569 3.232226e-01 0.490 0 0
Host Interactions of HIV factors R-HSA-162909 3.150063e-01 0.502 0 0
PI Metabolism R-HSA-1483255 2.000477e-01 0.699 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.494587e-01 0.603 0 0
Tie2 Signaling R-HSA-210993 2.799893e-01 0.553 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.218886e-01 0.375 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.795344e-01 0.421 0 0
Formation of the anterior neural plate R-HSA-9823739 4.488539e-01 0.348 0 0
Specification of primordial germ cells R-HSA-9827857 2.585619e-01 0.587 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.306293e-01 0.275 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.494993e-01 0.260 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.616125e-01 0.442 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.551601e-01 0.593 0 0
The NLRP1 inflammasome R-HSA-844455 3.296716e-01 0.482 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.494587e-01 0.603 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 4.727285e-01 0.325 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.664699e-01 0.436 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.087018e-01 0.510 0 0
Regulation of PTEN localization R-HSA-8948747 5.507157e-01 0.259 0 0
FLT3 signaling in disease R-HSA-9682385 4.503548e-01 0.346 0 0
Signaling by NOTCH4 R-HSA-9013694 4.829348e-01 0.316 0 0
Signaling by PTK6 R-HSA-8848021 3.421659e-01 0.466 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.421659e-01 0.466 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.448785e-01 0.462 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 4.954600e-01 0.305 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.087018e-01 0.510 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.045174e-01 0.689 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.660396e-01 0.436 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.660396e-01 0.436 0 0
RSV-host interactions R-HSA-9833110 4.493355e-01 0.347 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.676886e-01 0.330 0 0
Signaling by FGFR in disease R-HSA-1226099 4.829348e-01 0.316 0 0
Signaling by TGFB family members R-HSA-9006936 4.548416e-01 0.342 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.165001e-01 0.665 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.049999e-01 0.688 0 0
Josephin domain DUBs R-HSA-5689877 2.788871e-01 0.555 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.916060e-01 0.308 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.238500e-01 0.281 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.252141e-01 0.280 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.408477e-01 0.618 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.302717e-01 0.366 0 0
Neurodegenerative Diseases R-HSA-8863678 4.302717e-01 0.366 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.507157e-01 0.259 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.916060e-01 0.308 0 0
Signaling by Leptin R-HSA-2586552 2.788871e-01 0.555 0 0
Glycolysis R-HSA-70171 3.965115e-01 0.402 0 0
Interleukin-7 signaling R-HSA-1266695 4.510464e-01 0.346 0 0
Interleukin-37 signaling R-HSA-9008059 3.257549e-01 0.487 0 0
Death Receptor Signaling R-HSA-73887 2.224555e-01 0.653 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.508800e-01 0.259 0 0
MAPK family signaling cascades R-HSA-5683057 5.518497e-01 0.258 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.666879e-01 0.247 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.666883e-01 0.247 0 0
EGFR downregulation R-HSA-182971 5.679142e-01 0.246 0 0
Cargo concentration in the ER R-HSA-5694530 5.679142e-01 0.246 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.679142e-01 0.246 0 0
Cellular responses to stimuli R-HSA-8953897 5.693266e-01 0.245 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.720001e-01 0.243 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.720001e-01 0.243 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.720001e-01 0.243 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.720001e-01 0.243 0 0
Regulation of signaling by CBL R-HSA-912631 5.720001e-01 0.243 0 0
G2/M Transition R-HSA-69275 5.729591e-01 0.242 0 0
ESR-mediated signaling R-HSA-8939211 5.794288e-01 0.237 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.799361e-01 0.237 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.805225e-01 0.236 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.805225e-01 0.236 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.805225e-01 0.236 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.809937e-01 0.236 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.809937e-01 0.236 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.852738e-01 0.233 0 0
MET receptor recycling R-HSA-8875656 5.852738e-01 0.233 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 5.852738e-01 0.233 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 5.852738e-01 0.233 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 5.852738e-01 0.233 0 0
Sodium/Proton exchangers R-HSA-425986 5.852738e-01 0.233 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.852738e-01 0.233 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.914462e-01 0.228 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.923441e-01 0.227 0 0
Interleukin-17 signaling R-HSA-448424 5.923441e-01 0.227 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 5.941035e-01 0.226 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.941035e-01 0.226 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.941035e-01 0.226 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.941035e-01 0.226 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.941035e-01 0.226 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.941035e-01 0.226 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.941035e-01 0.226 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.969192e-01 0.224 0 0
Netrin-1 signaling R-HSA-373752 5.973539e-01 0.224 0 0
RMTs methylate histone arginines R-HSA-3214858 5.973539e-01 0.224 0 0
Glucose metabolism R-HSA-70326 6.009925e-01 0.221 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.027956e-01 0.220 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.033175e-01 0.219 0 0
Cilium Assembly R-HSA-5617833 6.035266e-01 0.219 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.045720e-01 0.219 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.045720e-01 0.219 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.100102e-01 0.215 0 0
Somitogenesis R-HSA-9824272 6.121902e-01 0.213 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.153409e-01 0.211 0 0
Signalling to RAS R-HSA-167044 6.153409e-01 0.211 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.153409e-01 0.211 0 0
ERK/MAPK targets R-HSA-198753 6.153409e-01 0.211 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.153409e-01 0.211 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.153409e-01 0.211 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.165972e-01 0.210 0 0
Interleukin-21 signaling R-HSA-9020958 6.171756e-01 0.210 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.171756e-01 0.210 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.171756e-01 0.210 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.171756e-01 0.210 0 0
mRNA Editing R-HSA-75072 6.171756e-01 0.210 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.171756e-01 0.210 0 0
ARMS-mediated activation R-HSA-170984 6.171756e-01 0.210 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 6.171756e-01 0.210 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.171756e-01 0.210 0 0
Lipophagy R-HSA-9613354 6.171756e-01 0.210 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.171756e-01 0.210 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.184464e-01 0.209 0 0
Striated Muscle Contraction R-HSA-390522 6.202832e-01 0.207 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.266834e-01 0.203 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.327869e-01 0.199 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.357148e-01 0.197 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.358232e-01 0.197 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.365729e-01 0.196 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.367476e-01 0.196 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.367476e-01 0.196 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.408267e-01 0.193 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.459361e-01 0.190 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.466253e-01 0.189 0 0
DNA replication initiation R-HSA-68952 6.466253e-01 0.189 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.466253e-01 0.189 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.466253e-01 0.189 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.466253e-01 0.189 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.466253e-01 0.189 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.513998e-01 0.186 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.527061e-01 0.185 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.527061e-01 0.185 0 0
GPER1 signaling R-HSA-9634597 6.546144e-01 0.184 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.552322e-01 0.184 0 0
FGFR2 alternative splicing R-HSA-6803529 6.552322e-01 0.184 0 0
LDL clearance R-HSA-8964038 6.552322e-01 0.184 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.552322e-01 0.184 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 6.552322e-01 0.184 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.552322e-01 0.184 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.558246e-01 0.183 0 0
Selective autophagy R-HSA-9663891 6.569438e-01 0.182 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.625604e-01 0.179 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.640278e-01 0.178 0 0
Developmental Cell Lineages R-HSA-9734767 6.646944e-01 0.177 0 0
HCMV Infection R-HSA-9609646 6.651680e-01 0.177 0 0
Degradation of CDH1 R-HSA-9766229 6.680424e-01 0.175 0 0
HSF1 activation R-HSA-3371511 6.681560e-01 0.175 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.681560e-01 0.175 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.720085e-01 0.173 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.734946e-01 0.172 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 6.738110e-01 0.171 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 6.738110e-01 0.171 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 6.738110e-01 0.171 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.738110e-01 0.171 0 0
PECAM1 interactions R-HSA-210990 6.738110e-01 0.171 0 0
Prostanoid ligand receptors R-HSA-391908 6.738110e-01 0.171 0 0
Interleukin-2 signaling R-HSA-9020558 6.738110e-01 0.171 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.739043e-01 0.171 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.739043e-01 0.171 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.739043e-01 0.171 0 0
Formation of the ureteric bud R-HSA-9830674 6.739043e-01 0.171 0 0
Growth hormone receptor signaling R-HSA-982772 6.739043e-01 0.171 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.782645e-01 0.169 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.814050e-01 0.167 0 0
Degradation of DVL R-HSA-4641258 6.830971e-01 0.166 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.830971e-01 0.166 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.830971e-01 0.166 0 0
PCP/CE pathway R-HSA-4086400 6.841992e-01 0.165 0 0
RNA Polymerase I Transcription R-HSA-73864 6.841992e-01 0.165 0 0
Interferon Signaling R-HSA-913531 6.843660e-01 0.165 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.862787e-01 0.163 0 0
Potential therapeutics for SARS R-HSA-9679191 6.908924e-01 0.161 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.917458e-01 0.160 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.917458e-01 0.160 0 0
Cellular response to hypoxia R-HSA-1234174 6.933922e-01 0.159 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.933922e-01 0.159 0 0
HSF1-dependent transactivation R-HSA-3371571 6.938084e-01 0.159 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.946721e-01 0.158 0 0
IRE1alpha activates chaperones R-HSA-381070 6.969016e-01 0.157 0 0
MET promotes cell motility R-HSA-8875878 6.975307e-01 0.156 0 0
SARS-CoV Infections R-HSA-9679506 6.981588e-01 0.156 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.989068e-01 0.156 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 6.989068e-01 0.156 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 6.989068e-01 0.156 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.989068e-01 0.156 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.028163e-01 0.153 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.087737e-01 0.149 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.087737e-01 0.149 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.087737e-01 0.149 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.087737e-01 0.149 0 0
Hyaluronan degradation R-HSA-2160916 7.087737e-01 0.149 0 0
L1CAM interactions R-HSA-373760 7.111814e-01 0.148 0 0
Influenza Infection R-HSA-168255 7.134978e-01 0.147 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.154186e-01 0.145 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 7.181145e-01 0.144 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.220733e-01 0.141 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.220733e-01 0.141 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.220733e-01 0.141 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.220733e-01 0.141 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.220733e-01 0.141 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.220733e-01 0.141 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.220733e-01 0.141 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.220733e-01 0.141 0 0
Regulation of IFNG signaling R-HSA-877312 7.220733e-01 0.141 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 7.220733e-01 0.141 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.220733e-01 0.141 0 0
OAS antiviral response R-HSA-8983711 7.220733e-01 0.141 0 0
Attenuation phase R-HSA-3371568 7.248893e-01 0.140 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.248893e-01 0.140 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.248893e-01 0.140 0 0
Glycogen metabolism R-HSA-8982491 7.248893e-01 0.140 0 0
Generation of second messenger molecules R-HSA-202433 7.248893e-01 0.140 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.250077e-01 0.140 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.250077e-01 0.140 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.250077e-01 0.140 0 0
Metalloprotease DUBs R-HSA-5689901 7.250077e-01 0.140 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.250077e-01 0.140 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.250077e-01 0.140 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.250077e-01 0.140 0 0
Homology Directed Repair R-HSA-5693538 7.274499e-01 0.138 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.378247e-01 0.132 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.378247e-01 0.132 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.404692e-01 0.130 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.404692e-01 0.130 0 0
Cristae formation R-HSA-8949613 7.404692e-01 0.130 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.404692e-01 0.130 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.409666e-01 0.130 0 0
HCMV Late Events R-HSA-9610379 7.411227e-01 0.130 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.434585e-01 0.129 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 7.434585e-01 0.129 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.434585e-01 0.129 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.434585e-01 0.129 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.434585e-01 0.129 0 0
Processing of SMDT1 R-HSA-8949664 7.434585e-01 0.129 0 0
tRNA processing R-HSA-72306 7.434740e-01 0.129 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.463116e-01 0.127 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.463116e-01 0.127 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.502733e-01 0.125 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.502733e-01 0.125 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.506862e-01 0.125 0 0
TNF signaling R-HSA-75893 7.518531e-01 0.124 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.551807e-01 0.122 0 0
Inflammasomes R-HSA-622312 7.551807e-01 0.122 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.560396e-01 0.121 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.560396e-01 0.121 0 0
Co-inhibition by PD-1 R-HSA-389948 7.603222e-01 0.119 0 0
Regulation of CDH1 Function R-HSA-9764561 7.623843e-01 0.118 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.631994e-01 0.117 0 0
cGMP effects R-HSA-418457 7.631994e-01 0.117 0 0
Physiological factors R-HSA-5578768 7.631994e-01 0.117 1 1
Signaling by FGFR4 in disease R-HSA-5655291 7.631994e-01 0.117 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.631994e-01 0.117 0 0
Regulation of KIT signaling R-HSA-1433559 7.631994e-01 0.117 0 0
HDL assembly R-HSA-8963896 7.631994e-01 0.117 0 0
Signal regulatory protein family interactions R-HSA-391160 7.631994e-01 0.117 0 0
MHC class II antigen presentation R-HSA-2132295 7.653952e-01 0.116 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.672713e-01 0.115 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.672713e-01 0.115 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.672713e-01 0.115 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.691663e-01 0.114 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.727495e-01 0.112 0 0
Signaling by FGFR4 R-HSA-5654743 7.737430e-01 0.111 0 0
Ca2+ pathway R-HSA-4086398 7.746515e-01 0.111 0 0
Signaling by ROBO receptors R-HSA-376176 7.773593e-01 0.109 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.783397e-01 0.109 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.814224e-01 0.107 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.814224e-01 0.107 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.814224e-01 0.107 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.814224e-01 0.107 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.814224e-01 0.107 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.814224e-01 0.107 0 0
Extension of Telomeres R-HSA-180786 7.823983e-01 0.107 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.823983e-01 0.107 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.824504e-01 0.107 0 0
Signaling by ERBB4 R-HSA-1236394 7.835404e-01 0.106 0 0
DAP12 interactions R-HSA-2172127 7.847828e-01 0.105 0 0
Surfactant metabolism R-HSA-5683826 7.847828e-01 0.105 0 0
Signaling by VEGF R-HSA-194138 7.862879e-01 0.104 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.877974e-01 0.104 0 0
Kinesins R-HSA-983189 7.918911e-01 0.101 0 0
Trafficking of AMPA receptors R-HSA-399719 7.950582e-01 0.100 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.950582e-01 0.100 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.950582e-01 0.100 0 0
Downstream signal transduction R-HSA-186763 7.950582e-01 0.100 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.953730e-01 0.099 0 0
Signaling by FGFR3 R-HSA-5654741 7.953730e-01 0.099 0 0
Nervous system development R-HSA-9675108 7.980777e-01 0.098 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.982440e-01 0.098 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.982440e-01 0.098 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.982440e-01 0.098 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.982440e-01 0.098 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 7.982440e-01 0.098 0 0
Differentiation of T cells R-HSA-9945266 7.982440e-01 0.098 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.982440e-01 0.098 0 0
Interleukin-12 signaling R-HSA-9020591 8.005002e-01 0.097 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.010488e-01 0.096 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.015462e-01 0.096 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.055242e-01 0.094 0 0
Diseases of DNA repair R-HSA-9675135 8.055242e-01 0.094 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.098773e-01 0.092 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.098773e-01 0.092 0 0
Macroautophagy R-HSA-1632852 8.102173e-01 0.091 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.137719e-01 0.089 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.137719e-01 0.089 0 0
Phase 2 - plateau phase R-HSA-5576893 8.137719e-01 0.089 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.137719e-01 0.089 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.137719e-01 0.089 0 0
DNA Repair R-HSA-73894 8.142115e-01 0.089 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.183464e-01 0.087 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.183464e-01 0.087 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.183833e-01 0.087 0 0
EPH-Ephrin signaling R-HSA-2682334 8.237185e-01 0.084 0 0
Protein folding R-HSA-391251 8.237185e-01 0.084 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 8.245560e-01 0.084 0 0
Insulin receptor signalling cascade R-HSA-74751 8.265735e-01 0.083 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.281057e-01 0.082 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.281057e-01 0.082 0 0
Glycogen storage diseases R-HSA-3229121 8.281057e-01 0.082 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.281057e-01 0.082 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.281057e-01 0.082 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.281057e-01 0.082 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.290777e-01 0.081 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.312550e-01 0.080 0 0
Signaling by FGFR2 R-HSA-5654738 8.312550e-01 0.080 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.329634e-01 0.079 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.329634e-01 0.079 0 0
Gap junction trafficking and regulation R-HSA-157858 8.334600e-01 0.079 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.334600e-01 0.079 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.334600e-01 0.079 0 0
DNA Damage Bypass R-HSA-73893 8.334600e-01 0.079 0 0
Interferon gamma signaling R-HSA-877300 8.359691e-01 0.078 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.383101e-01 0.077 0 0
Dual Incision in GG-NER R-HSA-5696400 8.392342e-01 0.076 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.392342e-01 0.076 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.392342e-01 0.076 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.392342e-01 0.076 0 0
Hyaluronan metabolism R-HSA-2142845 8.392342e-01 0.076 0 0
Signaling by NOTCH2 R-HSA-1980145 8.392342e-01 0.076 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.413369e-01 0.075 0 0
Nephron development R-HSA-9831926 8.413369e-01 0.075 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.413369e-01 0.075 0 0
PKA activation R-HSA-163615 8.413369e-01 0.075 0 0
PKA activation in glucagon signalling R-HSA-164378 8.413369e-01 0.075 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.413369e-01 0.075 0 0
Platelet sensitization by LDL R-HSA-432142 8.413369e-01 0.075 0 0
GAB1 signalosome R-HSA-180292 8.413369e-01 0.075 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.419724e-01 0.075 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.419724e-01 0.075 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.434117e-01 0.074 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.434117e-01 0.074 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.434117e-01 0.074 0 0
Chromosome Maintenance R-HSA-73886 8.443859e-01 0.073 0 0
Signaling by Interleukins R-HSA-449147 8.460719e-01 0.073 0 0
Axon guidance R-HSA-422475 8.477157e-01 0.072 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.487698e-01 0.071 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.488407e-01 0.071 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.488407e-01 0.071 0 0
PERK regulates gene expression R-HSA-381042 8.488407e-01 0.071 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.492172e-01 0.071 0 0
Kidney development R-HSA-9830369 8.493208e-01 0.071 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.498603e-01 0.071 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.498603e-01 0.071 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.501053e-01 0.071 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.535504e-01 0.069 0 0
The NLRP3 inflammasome R-HSA-844456 8.535504e-01 0.069 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.535504e-01 0.069 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.535504e-01 0.069 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.563203e-01 0.067 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.578711e-01 0.067 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.579217e-01 0.067 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.579217e-01 0.067 0 0
Calmodulin induced events R-HSA-111933 8.579217e-01 0.067 0 0
CaM pathway R-HSA-111997 8.579217e-01 0.067 0 0
Glycosphingolipid transport R-HSA-9845576 8.579217e-01 0.067 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.579217e-01 0.067 0 0
Integration of energy metabolism R-HSA-163685 8.611602e-01 0.065 0 0
Telomere Maintenance R-HSA-157579 8.613893e-01 0.065 0 0
Meiosis R-HSA-1500620 8.641438e-01 0.063 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.641438e-01 0.063 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.648245e-01 0.063 0 0
Glycogen synthesis R-HSA-3322077 8.648245e-01 0.063 0 0
Negative regulation of MET activity R-HSA-6807004 8.648245e-01 0.063 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.648245e-01 0.063 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.648245e-01 0.063 0 0
Nephrin family interactions R-HSA-373753 8.648245e-01 0.063 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.648245e-01 0.063 0 0
Smooth Muscle Contraction R-HSA-445355 8.652822e-01 0.063 0 0
Collagen chain trimerization R-HSA-8948216 8.665012e-01 0.062 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.670474e-01 0.062 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.707225e-01 0.060 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.714576e-01 0.060 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.746025e-01 0.058 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.746025e-01 0.058 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.750569e-01 0.058 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.752312e-01 0.058 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.752312e-01 0.058 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 8.752312e-01 0.058 0 0
Basigin interactions R-HSA-210991 8.752312e-01 0.058 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.752312e-01 0.058 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.802944e-01 0.055 0 0
Interleukin-12 family signaling R-HSA-447115 8.811623e-01 0.055 0 0
Stabilization of p53 R-HSA-69541 8.822484e-01 0.054 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.822484e-01 0.054 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.848374e-01 0.053 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.848374e-01 0.053 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.848374e-01 0.053 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 8.848374e-01 0.053 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.848374e-01 0.053 0 0
Signaling by FGFR1 R-HSA-5654736 8.855092e-01 0.053 0 0
Autophagy R-HSA-9612973 8.879312e-01 0.052 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.880333e-01 0.052 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.894609e-01 0.051 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.894609e-01 0.051 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.894609e-01 0.051 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 8.906928e-01 0.050 0 0
ER-Phagosome pathway R-HSA-1236974 8.914682e-01 0.050 0 0
IRS-mediated signalling R-HSA-112399 8.916233e-01 0.050 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.937045e-01 0.049 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.937045e-01 0.049 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.937045e-01 0.049 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.937045e-01 0.049 0 0
Ethanol oxidation R-HSA-71384 8.937045e-01 0.049 0 0
Signaling by KIT in disease R-HSA-9669938 8.937045e-01 0.049 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.939797e-01 0.049 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.939797e-01 0.049 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.962615e-01 0.048 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.962615e-01 0.048 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.962615e-01 0.048 0 0
Maturation of spike protein R-HSA-9694548 8.962615e-01 0.048 0 0
Reproduction R-HSA-1474165 8.965059e-01 0.047 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 8.966648e-01 0.047 0 0
Dual incision in TC-NER R-HSA-6782135 8.974429e-01 0.047 0 0
Protein ubiquitination R-HSA-8852135 8.979481e-01 0.047 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.018893e-01 0.045 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.018893e-01 0.045 0 0
Carnitine shuttle R-HSA-200425 9.018893e-01 0.045 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.022404e-01 0.045 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.026708e-01 0.044 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.026708e-01 0.044 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.026708e-01 0.044 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 9.042070e-01 0.044 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.052145e-01 0.043 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.080822e-01 0.042 0 0
Ca-dependent events R-HSA-111996 9.087086e-01 0.042 0 0
Toll-like Receptor Cascades R-HSA-168898 9.092937e-01 0.041 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.094444e-01 0.041 0 0
Complex III assembly R-HSA-9865881 9.094444e-01 0.041 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.094444e-01 0.041 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.094444e-01 0.041 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.094444e-01 0.041 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.094444e-01 0.041 0 0
Signaling by Insulin receptor R-HSA-74752 9.097853e-01 0.041 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.117102e-01 0.040 0 0
PLC beta mediated events R-HSA-112043 9.132498e-01 0.039 0 0
Phospholipid metabolism R-HSA-1483257 9.160676e-01 0.038 0 0
Tight junction interactions R-HSA-420029 9.164181e-01 0.038 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.164181e-01 0.038 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.164181e-01 0.038 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.164181e-01 0.038 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.164181e-01 0.038 0 0
Formation of the nephric duct R-HSA-9830364 9.164181e-01 0.038 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.164181e-01 0.038 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.197461e-01 0.036 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.197461e-01 0.036 0 0
Amine ligand-binding receptors R-HSA-375280 9.197461e-01 0.036 0 0
Gap junction trafficking R-HSA-190828 9.197461e-01 0.036 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.197461e-01 0.036 0 0
PKR-mediated signaling R-HSA-9833482 9.207922e-01 0.036 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.216887e-01 0.035 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.225214e-01 0.035 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.227137e-01 0.035 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.228551e-01 0.035 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.239632e-01 0.034 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.239632e-01 0.034 0 0
SLC transporter disorders R-HSA-5619102 9.244748e-01 0.034 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.247818e-01 0.034 0 0
Nucleosome assembly R-HSA-774815 9.247818e-01 0.034 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.247818e-01 0.034 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.247818e-01 0.034 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.247818e-01 0.034 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.247818e-01 0.034 0 0
DAG and IP3 signaling R-HSA-1489509 9.247818e-01 0.034 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.247818e-01 0.034 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.287967e-01 0.032 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.287967e-01 0.032 0 0
Interaction between L1 and Ankyrins R-HSA-445095 9.287967e-01 0.032 0 0
Triglyceride biosynthesis R-HSA-75109 9.287967e-01 0.032 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.287967e-01 0.032 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.287967e-01 0.032 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.295184e-01 0.032 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.305001e-01 0.031 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.305001e-01 0.031 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.339719e-01 0.030 0 0
Synthesis of PC R-HSA-1483191 9.339719e-01 0.030 0 0
Telomere Extension By Telomerase R-HSA-171319 9.342811e-01 0.030 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.342811e-01 0.030 0 0
Insulin receptor recycling R-HSA-77387 9.342811e-01 0.030 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.342811e-01 0.030 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.342811e-01 0.030 0 0
Pyrimidine salvage R-HSA-73614 9.342811e-01 0.030 0 0
Pyroptosis R-HSA-5620971 9.342811e-01 0.030 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.353876e-01 0.029 0 0
Signaling by FGFR R-HSA-190236 9.353876e-01 0.029 0 0
Co-stimulation by CD28 R-HSA-389356 9.381579e-01 0.028 0 0
G-protein mediated events R-HSA-112040 9.383971e-01 0.028 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.393433e-01 0.027 0 0
Platelet calcium homeostasis R-HSA-418360 9.393433e-01 0.027 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.393433e-01 0.027 0 0
DARPP-32 events R-HSA-180024 9.393433e-01 0.027 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.393433e-01 0.027 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.393433e-01 0.027 0 0
Hedgehog 'off' state R-HSA-5610787 9.413975e-01 0.026 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.440159e-01 0.025 0 0
PI3K Cascade R-HSA-109704 9.457857e-01 0.024 0 0
COPII-mediated vesicle transport R-HSA-204005 9.482675e-01 0.023 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.483287e-01 0.023 0 0
Budding and maturation of HIV virion R-HSA-162588 9.483287e-01 0.023 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.483287e-01 0.023 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.492550e-01 0.023 0 0
Cellular response to chemical stress R-HSA-9711123 9.502293e-01 0.022 0 0
Diseases of programmed cell death R-HSA-9645723 9.506394e-01 0.022 0 0
Hedgehog 'on' state R-HSA-5632684 9.512161e-01 0.022 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.523096e-01 0.021 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.525118e-01 0.021 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.525118e-01 0.021 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.525118e-01 0.021 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.525118e-01 0.021 0 0
Neurotransmitter release cycle R-HSA-112310 9.556824e-01 0.020 0 0
Base Excision Repair R-HSA-73884 9.556824e-01 0.020 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.559840e-01 0.020 0 0
G-protein beta:gamma signalling R-HSA-397795 9.559840e-01 0.020 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.559840e-01 0.020 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.593755e-01 0.018 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.593755e-01 0.018 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.593755e-01 0.018 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.625059e-01 0.017 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.625059e-01 0.017 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.625059e-01 0.017 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.625059e-01 0.017 0 0
Mitophagy R-HSA-5205647 9.625059e-01 0.017 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.625059e-01 0.017 0 0
eNOS activation R-HSA-203615 9.625059e-01 0.017 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.625059e-01 0.017 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.626624e-01 0.017 0 0
Ion homeostasis R-HSA-5578775 9.636480e-01 0.016 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.653952e-01 0.015 0 0
Regulation of Apoptosis R-HSA-169911 9.653952e-01 0.015 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.653952e-01 0.015 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.653952e-01 0.015 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.653952e-01 0.015 0 0
Collagen formation R-HSA-1474290 9.662814e-01 0.015 0 0
TCR signaling R-HSA-202403 9.663023e-01 0.015 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.671657e-01 0.014 0 0
Leishmania phagocytosis R-HSA-9664417 9.671657e-01 0.014 0 0
Parasite infection R-HSA-9664407 9.671657e-01 0.014 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.680620e-01 0.014 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.680620e-01 0.014 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.680620e-01 0.014 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.686523e-01 0.014 0 0
Ub-specific processing proteases R-HSA-5689880 9.696641e-01 0.013 0 0
Platelet degranulation R-HSA-114608 9.702765e-01 0.013 0 0
Peroxisomal protein import R-HSA-9033241 9.703055e-01 0.013 0 0
Degradation of AXIN R-HSA-4641257 9.705235e-01 0.013 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.705235e-01 0.013 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.705235e-01 0.013 0 0
NCAM1 interactions R-HSA-419037 9.705235e-01 0.013 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.705235e-01 0.013 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.714543e-01 0.013 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.715152e-01 0.013 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.722510e-01 0.012 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.722510e-01 0.012 0 0
Viral Infection Pathways R-HSA-9824446 9.725148e-01 0.012 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.726194e-01 0.012 0 0
Purine salvage R-HSA-74217 9.727954e-01 0.012 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.727954e-01 0.012 0 0
Amyloid fiber formation R-HSA-977225 9.731955e-01 0.012 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.740170e-01 0.011 0 0
Nucleotide salvage R-HSA-8956321 9.740732e-01 0.011 0 0
Collagen degradation R-HSA-1442490 9.740732e-01 0.011 0 0
Regulation of insulin secretion R-HSA-422356 9.744797e-01 0.011 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.748923e-01 0.011 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.748923e-01 0.011 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.748923e-01 0.011 0 0
Pentose phosphate pathway R-HSA-71336 9.748923e-01 0.011 0 0
Mitochondrial protein import R-HSA-1268020 9.757794e-01 0.011 0 0
Signaling by PDGF R-HSA-186797 9.757794e-01 0.011 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.762781e-01 0.010 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.768277e-01 0.010 0 0
Diseases of Immune System R-HSA-5260271 9.768277e-01 0.010 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.768277e-01 0.010 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.774526e-01 0.010 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.786140e-01 0.009 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.786140e-01 0.009 0 0
FLT3 Signaling R-HSA-9607240 9.786140e-01 0.009 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.788720e-01 0.009 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.790124e-01 0.009 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.802627e-01 0.009 0 0
Intra-Golgi traffic R-HSA-6811438 9.802627e-01 0.009 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.802627e-01 0.009 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.802773e-01 0.009 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.814610e-01 0.008 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.817844e-01 0.008 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.817844e-01 0.008 0 0
Depyrimidination R-HSA-73928 9.817844e-01 0.008 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.817844e-01 0.008 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.817844e-01 0.008 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.818477e-01 0.008 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.822760e-01 0.008 0 0
Interleukin-1 family signaling R-HSA-446652 9.822760e-01 0.008 0 0
Defective pyroptosis R-HSA-9710421 9.831889e-01 0.007 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.831889e-01 0.007 0 0
Signaling by SCF-KIT R-HSA-1433557 9.831889e-01 0.007 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.836376e-01 0.007 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.839505e-01 0.007 0 0
Regulated Necrosis R-HSA-5218859 9.839505e-01 0.007 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.844851e-01 0.007 0 0
Proteasome assembly R-HSA-9907900 9.844851e-01 0.007 0 0
Downstream TCR signaling R-HSA-202424 9.855512e-01 0.006 0 0
Formation of the cornified envelope R-HSA-6809371 9.855762e-01 0.006 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.855877e-01 0.006 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.856815e-01 0.006 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.856815e-01 0.006 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.860231e-01 0.006 0 0
Stimuli-sensing channels R-HSA-2672351 9.864013e-01 0.006 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.867857e-01 0.006 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.867857e-01 0.006 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.867857e-01 0.006 0 0
Cellular response to starvation R-HSA-9711097 9.867956e-01 0.006 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.872567e-01 0.006 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.880351e-01 0.005 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.886519e-01 0.005 0 0
Metal ion SLC transporters R-HSA-425410 9.887453e-01 0.005 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.887678e-01 0.005 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.890868e-01 0.005 0 0
Muscle contraction R-HSA-397014 9.890868e-01 0.005 1 0
FCERI mediated MAPK activation R-HSA-2871796 9.892391e-01 0.005 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.894571e-01 0.005 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.896134e-01 0.005 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.901056e-01 0.004 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.901295e-01 0.004 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.901888e-01 0.004 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.904146e-01 0.004 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.907156e-01 0.004 0 0
Meiotic recombination R-HSA-912446 9.911540e-01 0.004 0 0
Complex IV assembly R-HSA-9864848 9.911540e-01 0.004 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.911540e-01 0.004 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.911540e-01 0.004 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.912892e-01 0.004 0 0
Translation of Structural Proteins R-HSA-9694635 9.914186e-01 0.004 0 0
Interferon alpha/beta signaling R-HSA-909733 9.919970e-01 0.003 0 0
Interleukin-10 signaling R-HSA-6783783 9.920000e-01 0.003 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.924662e-01 0.003 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.924662e-01 0.003 0 0
Neddylation R-HSA-8951664 9.927533e-01 0.003 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.930475e-01 0.003 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.930475e-01 0.003 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.931280e-01 0.003 0 0
Protein localization R-HSA-9609507 9.933422e-01 0.003 0 0
G alpha (z) signalling events R-HSA-418597 9.935839e-01 0.003 0 0
Interleukin-1 signaling R-HSA-9020702 9.936805e-01 0.003 0 0
Signaling by Hedgehog R-HSA-5358351 9.944159e-01 0.002 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.944356e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.945359e-01 0.002 0 0
Opioid Signalling R-HSA-111885 9.947956e-01 0.002 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.950544e-01 0.002 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.951488e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.953467e-01 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.953467e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.957059e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.957059e-01 0.002 0 0
Platelet homeostasis R-HSA-418346 9.957187e-01 0.002 0 0
Aquaporin-mediated transport R-HSA-445717 9.960373e-01 0.002 0 0
Peptide chain elongation R-HSA-156902 9.963266e-01 0.002 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.963432e-01 0.002 0 0
Transmission across Chemical Synapses R-HSA-112315 9.965955e-01 0.001 0 0
Neuronal System R-HSA-112316 9.965992e-01 0.001 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.966255e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.966255e-01 0.001 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.968889e-01 0.001 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.970349e-01 0.001 0 0
Cardiac conduction R-HSA-5576891 9.973224e-01 0.001 1 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.973483e-01 0.001 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.974306e-01 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.974306e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.975530e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.976660e-01 0.001 0 0
Leishmania infection R-HSA-9658195 9.977478e-01 0.001 0 0
Parasitic Infection Pathways R-HSA-9824443 9.977478e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.977742e-01 0.001 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.980725e-01 0.001 0 0
Eukaryotic Translation Termination R-HSA-72764 9.980725e-01 0.001 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.980772e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.982065e-01 0.001 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.982065e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.982257e-01 0.001 0 0
Ribosome-associated quality control R-HSA-9948299 9.983751e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.986059e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.986566e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.987136e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.987136e-01 0.001 0 0
Selenocysteine synthesis R-HSA-2408557 9.987504e-01 0.001 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.987673e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.988339e-01 0.001 0 0
Viral mRNA Translation R-HSA-192823 9.989191e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.989893e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.989893e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.989893e-01 0.000 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.992981e-01 0.000 0 0
rRNA processing R-HSA-72312 9.993467e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.994235e-01 0.000 0 0
Adaptive Immune System R-HSA-1280218 9.994922e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.995479e-01 0.000 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.995756e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.995828e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.996387e-01 0.000 0 0
Hemostasis R-HSA-109582 9.996585e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.996882e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.997702e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.998135e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998432e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.998510e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.999054e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999268e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999456e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999486e-01 0.000 0 0
Neutrophil degranulation R-HSA-6798695 9.999662e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999852e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999920e-01 0.000 1 0
G alpha (q) signalling events R-HSA-416476 9.999923e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999968e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999968e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999978e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999978e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999981e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999982e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999986e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999988e-01 0.000 0 0
Translation R-HSA-72766 9.999992e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999993e-01 0.000 0 0
Disease R-HSA-1643685 9.999994e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999996e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Immune System R-HSA-168256 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 1 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways