PKCG

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1065 Sugiyama POTEF A26C1B ILASLSTFQQMWISKQEyDEsGPsIVHRKCL__________
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00571 S82 Sugiyama DDX3X DBX DDX3 ssKDKDAyssFGsRsDsRGKssFFsDRGsGsRGRFDDRGRs
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S196 Sugiyama EIF5B IF2 KIAA0741 ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O94768 S351 SIGNOR STK17B DRAK2 NGTCGDREDKENIPEDssMVsKRFRFDDSLPNPHELVSDLL
O95544 S46 PSP NADK CHGDETWSYNHPIRGRAKsRsLsAsPALGsTKEFRRtRsLH
O95544 S64 PSP NADK sRsLsAsPALGsTKEFRRtRsLHGPCPVTTFGPKACVLQNP
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 S167 Sugiyama LDHA PIG19 AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04004 S381 SIGNOR|iPTMNet|EPSD VTN PRPsLAKKQRFRHRNRKGYRsQRGHsRGRNQNsRRPsRAtW
P04049 S497 SIGNOR RAF1 RAF HEGLtVKIGDFGLAtVKsRWsGsQQVEQPTGSVLWMAPEVI
P04049 S619 SIGNOR RAF1 RAF FPQILssIELLQHsLPKINRsAsEPsLHRAAHtEDINACtL
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04083 S27 SIGNOR ANXA1 ANX1 LPC1 FLKQAWFIENEEQEyVQtVKssKGGPGsAVsPyPtFNPssD
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04637 S46 EPSD TP53 P53 LPENNVLsPLPsQAMDDLMLsPDDIEQWFtEDPGPDEAPRM
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S83 Sugiyama HSPB1 HSP27 HSP28 IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P04792 S86 Sugiyama HSPB1 HSP27 HSP28 PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP
P05129 S145 Sugiyama PRKCG PKCG VHQGMKCSCCEMNVHRRCVRsVPsLCGVDHTERRGRLQLEI
P05129 S148 Sugiyama PRKCG PKCG GMKCSCCEMNVHRRCVRsVPsLCGVDHTERRGRLQLEIRAP
P05129 S297 Sugiyama PRKCG PKCG LLNQEEGEYYNVPVADADNCsLLQKFEACNYPLELYERVRM
P05129 S326 Sugiyama PRKCG PKCG NYPLELYERVRMGPsssPIPsPsPsPtDPKRCFFGAsPGRL
P05129 S328 Sugiyama PRKCG PKCG PLELYERVRMGPsssPIPsPsPsPtDPKRCFFGAsPGRLHI
P05129 S330 Sugiyama PRKCG PKCG ELYERVRMGPsssPIPsPsPsPtDPKRCFFGAsPGRLHISD
P05129 S342 Sugiyama PRKCG PKCG sPIPsPsPsPtDPKRCFFGAsPGRLHISDFSFLMVLGKGSF
P05129 S373 Sugiyama PRKCG PKCG FLMVLGKGSFGKVMLAERRGsDELYAIKILKKDVIVQDDDV
P05129 S600 Sugiyama PRKCG PKCG REAVAICKGFLTKHPGKRLGsGPDGEPtIRAHGFFRWIDWE
P05129 S664 Sugiyama PRKCG PKCG DKFFTRAAPALtPPDRLVLAsIDQADFQGFtYVNPDFVHPD
P05129 S70 Sugiyama PRKCG PKCG SHCTDFIWGIGKQGLQCQVCsFVVHRRCHEFVTFECPGAGK
P05129 T332 Sugiyama PRKCG PKCG YERVRMGPsssPIPsPsPsPtDPKRCFFGAsPGRLHISDFS
P05129 T396 Sugiyama PRKCG PKCG LYAIKILKKDVIVQDDDVDCtLVEKRVLALGGRGPGGRPHF
P05129 T510 Sugiyama PRKCG PKCG AEGHIKITDFGMCKENVFPGtTTRtFCGtPDyIAPEIIAyQ
P05129 T514 Sugiyama PRKCG PKCG IKITDFGMCKENVFPGtTTRtFCGtPDyIAPEIIAyQPYGK
P05129 T518 Sugiyama PRKCG PKCG DFGMCKENVFPGtTTRtFCGtPDyIAPEIIAyQPYGKSVDW
P05129 T607 Sugiyama PRKCG PKCG KGFLTKHPGKRLGsGPDGEPtIRAHGFFRWIDWERLERLEI
P05129 T655 Sugiyama PRKCG PKCG PCGRSGENFDKFFTRAAPALtPPDRLVLAsIDQADFQGFtY
P05129 T674 Sugiyama PRKCG PKCG LtPPDRLVLAsIDQADFQGFtYVNPDFVHPDARSPTSPVPV
P05771 T500 Sugiyama PRKCB PKCB PRKCB1 IKIADFGMCKENIWDGVttKtFCGtPDyIAPEIIAyQPYGK
P05771 T504 Sugiyama PRKCB PKCB PRKCB1 DFGMCKENIWDGVttKtFCGtPDyIAPEIIAyQPYGKSVDW
P05783 S93 Sugiyama KRT18 CYK18 PIG46 GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06127 T434 SIGNOR|iPTMNet|EPSD|PSP CD5 LEU1 QRQWIGPTGMNQNMsFHRNHtAtVRsHAENPtASHVDNEys
P06127 T436 SIGNOR|iPTMNet|EPSD|PSP CD5 LEU1 QWIGPTGMNQNMsFHRNHtAtVRsHAENPtASHVDNEysQP
P06730 S209 SIGNOR|iPTMNet|EPSD EIF4E EIF4EL1 EIF4F LPPKIVIGyQsHADTAtKsGsttKNRFVV____________
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S168 Sugiyama LDHB TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07437 S75 Sugiyama TUBB TUBB5 OK/SW-cl.56 tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07864 S167 Sugiyama LDHC LDH3 LDHX VWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVHPTSCHG
P07900 T115 SIGNOR|EPSD|PSP HSP90AA1 HSP90A HSPC1 HSPCA GIGMTKADLINNLGtIAKSGtKAFMEALQAGADISMIGQFG
P07900 T425 SIGNOR|EPSD|PSP HSP90AA1 HSP90A HSPC1 HSPCA QsKILKVIRKNLVKKCLELFtELAEDKENyKKFyEQFSKNI
P07900 T603 SIGNOR|EPSD|PSP HSP90AA1 HSP90A HSPC1 HSPCA VEKVVVSNRLVtsPCCIVtstyGWTANMERIMKAQALRDNs
P08138 S277 EPSD|PSP NGFR TNFRSF16 SILAAVVVGLVAYIAFKRWNsCKQNKQGANsRPVNQtPPPE
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09211 S185 SIGNOR GSTP1 FAEES3 GST3 VLAPGCLDAFPLLSAYVGRLsARPKLKAFLASPEyVNLPIN
P09211 S43 SIGNOR GSTP1 FAEES3 GST3 ADQGQSWKEEVVTVETWQEGsLKASCLyGQLPKFQDGDLtL
P0CG38 S1065 Sugiyama POTEI ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1028 Sugiyama POTEJ ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10276 S157 GPS6 RARA NR1B1 RNRCQYCRLQKCFEVGMSKEsVRNDRNKKKKEVPKPECSES
P11142 S340 Sugiyama HSPA8 HSC70 HSP73 HSPA10 ALRDAKLDKsQIHDIVLVGGstRIPKIQKLLQDFFNGKELN
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11388 S29 SIGNOR|iPTMNet|EPSD TOP2A TOP2 VNENMQVNKIKKNEDAKKRLsVERIYQKKTQLEHILLRPDT
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618 S205 Sugiyama PKM OIP3 PK2 PK3 PKM2 VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17252 T497 Sugiyama PRKCA PKCA PRKACA IKIADFGMCKEHMMDGVttRtFCGtPDyIAPEIIAyQPYGK
P17252 T501 Sugiyama PRKCA PKCA PRKACA DFGMCKEHMMDGVttRtFCGtPDyIAPEIIAyQPYGKSVDW
P17302 S368 SIGNOR|iPTMNet|EPSD GJA1 GJAL AAGHELQPLAIVDQRPssRAssRAssRPRPDDLEI______
P18615 S131 Sugiyama NELFE RD RDBP QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19429 S42 SIGNOR TNNI3 TNNC1 RssNyRAYAtEPHAKKKsKIsAsRKLQLKtLLLQIAKQELE
P19429 S44 SIGNOR TNNI3 TNNC1 sNyRAYAtEPHAKKKsKIsAsRKLQLKtLLLQIAKQELERE
P20618 S162 Sugiyama PSMB1 PSC5 DEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLDNQVG
P21730 S334 EPSD|PSP C5AR1 C5AR C5R1 sLPsLLRNVLTEEsVVREsKsFTRsTVDTMAQKTQAV____
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23396 S104 Sugiyama RPS3 OK/SW-cl.26 VELyAEKVAtRGLCAIAQAEsLRyKLLGGLAVRRACyGVLR
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P23588 S597 Sugiyama EIF4B KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______
P25098 S29 SIGNOR|iPTMNet|EPSD|PSP GRK2 ADRBK1 BARK BARK1 ADVSyLMAMEKSKATPAARAsKKILLPEPSIRSVMQKYLED
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P28329 S464 SIGNOR|EPSD CHAT PFDGIVLVQCTEHLLKHVTQssRKLIRADsVSELPAPRRLR
P28329 S465 SIGNOR|EPSD CHAT FDGIVLVQCTEHLLKHVTQssRKLIRADsVSELPAPRRLRW
P28329 S558 SIGNOR|EPSD CHAT ALQLAFYRLHRRLVPTYESAsIRRFQEGRVDNIRSAtPEAL
P28329 S594 SIGNOR|EPSD CHAT tPEALAFVRAVTDHKAAVPAsEKLLLLKDAIRAQTAYTVMA
P28329 T373 SIGNOR|EPSD CHAT LTSDGRSEWAEARTVLVKDStNRDSLDMIERCICLVCLDAP
P29474 T495 SIGNOR NOS3 YQPDPWKGSAAKGTGITRKKtFKEVANAVKISASLMGTVMA
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P30086 S153 SIGNOR|iPTMNet|EPSD PEBP1 PBP PEBP CDEPILsNRsGDHRGKFKVAsFRKKyELRAPVAGtCyQAEW
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P33992 S423 Sugiyama MCM5 CDC46 ytsGKGSSAAGLtAsVMRDPssRNFIMEGGAMVLADGGVVC
P34741 S187 SIGNOR|iPTMNet|EPSD SDC2 HSPG1 LVYRMRKKDEGsyDLGERKPssAAYQKAPTKEFYA______
P34741 S188 SIGNOR|iPTMNet|EPSD SDC2 HSPG1 VYRMRKKDEGsyDLGERKPssAAYQKAPTKEFYA_______
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35568 S1101 iPTMNet|EPSD IRS1 RNQSAKVIRADPQGCRRRHssEtFsstPSATRVGNTVPFGA
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37108 S25 Sugiyama SRP14 EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38606 S384 Sugiyama ATP6V1A ATP6A1 ATP6V1A1 VPP2 RLAEMPADSGYPAyLGARLAsFYERAGRVKCLGNPEREGSV
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P41180 T888 iPTMNet|EPSD CASR GPRC2A PCAR1 TIEEVRCsTAAHAFKVAARAtLRRsNVsRKRsssLGGSTGS
P41594 S840 SIGNOR|iPTMNet|EPSD GRM5 GPRC1E MGLUR5 PKVYIILAKPERNVRSAFTTstVVRMHVGDGKSSSAASRSS
P41594 T841 SIGNOR GRM5 GPRC1E MGLUR5 KVYIILAKPERNVRSAFTTstVVRMHVGDGKSSSAASRSSS
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43629 S415 SIGNOR|EPSD|PSP KIR3DL1 CD158E NKAT3 NKB1 EVTYAQLDHCVFTQRKITRPsQRPKtPPTDTILYTELPNAK
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P47712 S724 Sugiyama PLA2G4A CPLA2 PLA2G4 NIDVIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFL
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48058 S862 SIGNOR GRIA4 GluA4 GLUR4 AEAKRMKLtFSEAIRNKARLsITGSVGENGRVLTPDCPKAV
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49768 S346 SIGNOR PSEN1 AD3 PS1 PSNL1 DtVAENDDGGFsEEWEAQRDsHLGPHRstPEsRAAVQELss
P49840 S21 SIGNOR|iPTMNet|EPSD|PSP GSK3A MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs
P49841 S9 EPSD|PSP GSK3B ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P50281 T567 EPSD|PSP MMP14 LLLLLVLAVGLAVFFFRRHGtPRRLLyCQRSLLDKV_____
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51991 S370 Sugiyama HNRNPA3 HNRPA3 sFGGRssGsPyGGGyGsGGGsGGyGsRRF____________
P51991 S375 Sugiyama HNRNPA3 HNRPA3 ssGsPyGGGyGsGGGsGGyGsRRF_________________
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S365 Sugiyama ACTB ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61764 S306 SIGNOR|iPTMNet|EPSD STXBP1 UNC18A DLWIALRHKHIAEVSQEVTRsLKDFSSsKRMNTGEKTTMRD
P61764 S313 SIGNOR|iPTMNet|EPSD STXBP1 UNC18A HKHIAEVSQEVTRsLKDFSSsKRMNTGEKTTMRDLSQMLKK
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978 S420 Sugiyama HNRNPK HNRPK GsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITItGt
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 S67 Sugiyama RPS11 PKEAIEGtyIDKKCPFTGNVsIRGRILsGVVTKMKMQRTIV
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62753 T127 Sugiyama RPS6 OK/SW-cl.2 SVLNLVIVKKGEKDIPGLtDttVPRRLGPKRASRIRKLFNL
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S365 Sugiyama ACTG1 ACTG ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P78417 S23 Sugiyama GSTO1 GSTTLP28 GESARsLGKGsAPPGPVPEGsIRIySMRFCPFAERTRLVLK
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S7 Sugiyama RPL24 ______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 S122 Sugiyama RPL19 LRRLLRRYRESKKIDRHMyHsLyLKVKGNVFKNKRILMEHI
P98082 S24 SIGNOR|iPTMNet|EPSD|PSP DAB2 DOC2 EVEtSATNGQPDQQAAPKAPsKKEKKKGPEKTDEyLLARFK
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q01970 S1105 GPS6 PLCB3 EMNEREKKELQKILDRKRHNsIsEAKMRDKHKKEAELTEIN
Q03721 S15 GPS6|ELM|EPSD|PSP KCNC4 C1orf30 ______MISSVCVssYRGRKsGNKPPsKTCLKEEMAKGEAS
Q03721 S21 GPS6|ELM|EPSD|PSP KCNC4 C1orf30 MISSVCVssYRGRKsGNKPPsKTCLKEEMAKGEASEKIIIN
Q03721 S8 GPS6|ELM|EPSD|PSP KCNC4 C1orf30 _____________MISSVCVssYRGRKsGNKPPsKTCLKEE
Q03721 S9 GPS6|ELM|EPSD|PSP KCNC4 C1orf30 ____________MISSVCVssYRGRKsGNKPPsKTCLKEEM
Q05586 S890 SIGNOR GRIN1 NMDAR1 AEPDPKKKATFRAITSTLAssFKRRRssKDTSTGGGRGALQ
Q07020 S64 Sugiyama RPL18 NQVVLKRLFMSRtNRPPLsLsRMIRKMKLPGRENKtAVVVG
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q13224 S1303 SIGNOR|iPTMNet|EPSD GRIN2B NMDAR2B QSPTNSKAQKKNRNKLRRQHsYDTFVDLQKEEAALAPRSVs
Q13224 S1323 SIGNOR|iPTMNet|EPSD GRIN2B NMDAR2B sYDTFVDLQKEEAALAPRSVsLKDKGRFMDGSPyAHMFEMS
Q13507 T646 PSP TRPC3 TRP3 IAYILPANESFGPLQISLGRtVKDIFKFMVLFIMVFFAFMI
Q13509 S75 Sugiyama TUBB3 TUBB4 SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13769 S314 Sugiyama THOC5 C22orf19 KIAA0983 VDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQLD
Q13885 S75 Sugiyama TUBB2A TUBB2 AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14155 S518 SIGNOR|EPSD|PSP ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314 ERYLLLFPNVLLMLSASPRMsGFIyQGKLPtTGMTITKLED
Q14155 S761 SIGNOR|EPSD|PSP ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314 HNHVLADDDQPSLDSLGRRSsLSRLEPSDLSEDSDYDSIWT
Q14697 S52 Sugiyama GANAB G2AN KIAA0088 AVDRSNFKtCEEssFCKRQRsIRPGLsPyRALLDSLQLGPD
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q16625 S340 SIGNOR|iPTMNet|EPSD OCLN DsPMAYSsNGKVNDKRFYPEssyKstPVPEVVQELPLtsPV
Q16629 S183 Sugiyama SRSF7 SFRS7 sRSISLRRSRSASLRRSRSGsIKGsRyFQsPsRsRsRSRSI
Q16629 S187 Sugiyama SRSF7 SFRS7 SLRRSRSASLRRSRSGsIKGsRyFQsPsRsRsRSRSISRPR
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q5JVS0 T354 SIGNOR|iPTMNet|EPSD HABP4 MVKDDYEDDSHVFRKPANDItSQLEINFGNLPRPGRGARGG
Q5JVS0 T375 SIGNOR|iPTMNet|EPSD HABP4 SQLEINFGNLPRPGRGARGGtRGGRGRIRRAENYGPRAEVV
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6PCE3 S175 Sugiyama PGM2L1 BM32A PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6PCE3 T173 Sugiyama PGM2L1 BM32A PTPFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQ
Q6S8J3 S1065 Sugiyama POTEE A26C1A POTE2 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZMR3 S167 Sugiyama LDHAL6A LDHL2 AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z2E3 T125 SIGNOR|EPSD|PSP APTX AXA1 NELYPYIVEFEEEAKNPGLEtHRKRKRsGNsDsIERDAAQE
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8N201 S495 Sugiyama INTS1 KIAA1440 UNQ1821/PRO3434 KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8WVK2 S132 Sugiyama SNRNP27 FDSTKGKKVDGsVNAyAINVsQKRKYRQYMNRKGGFNRPLD
Q92686 S36 SIGNOR|iPTMNet|EPSD NRGN ILDIPLDDPGANAAAAKIQAsFRGHMARKKIKSGERGRKGP
Q92890 S299 Sugiyama UFD1 UFD1L KKVEEDEAGGRFVAFsGEGQsLRKKGRKP____________
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99418 S392 SIGNOR|EPSD CYTH2 ARNO PSCD2 PSCD2L QAAVSVDPFYEMLAARKKRIsVKKKQEQP____________
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BVA1 S75 Sugiyama TUBB2B tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BYX7 S365 Sugiyama POTEKP ACTBL3 FKSG30 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9H3Z4 S10 EPSD|PSP DNAJC5 CLN4 ___________MADQRQRsLstsGEsLyHVLGLDKNATSDD
Q9H3Z4 S34 EPSD|PSP DNAJC5 CLN4 EsLyHVLGLDKNATSDDIKKsYRKLALKYHPDKNPDNPEAA
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9UBR2 S78 Sugiyama CTSZ SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST
Q9UBS0 S473 GPS6|SIGNOR|ELM|EPSD|PSP RPS6KB2 STK14B PPPPSTTAPLPIRPPSGTKKsKRGRGRPGR___________
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UQ80 S363 SIGNOR|iPTMNet|EPSD PA2G4 EBP1 yKsEMEVQDAELKALLQssAsRKtQKKKKKKAsKtAENAts
Q9UQ80 T366 SIGNOR|iPTMNet|EPSD PA2G4 EBP1 EMEVQDAELKALLQssAsRKtQKKKKKKAsKtAENAtsGEt
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y3B8 S203 Sugiyama REXO2 SFN SMFN CGI-114 EYEFAPKKAAsHRALDDIsEsIKELQFyRNNIFKKKIDEKK
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 8.578693e-13 12.067 0 0
Cell Cycle Checkpoints R-HSA-69620 1.773808e-10 9.751 0 0
Cellular Senescence R-HSA-2559583 1.097224e-09 8.960 0 0
Signal Transduction R-HSA-162582 1.098816e-09 8.959 1 0
Cell Cycle, Mitotic R-HSA-69278 3.026608e-09 8.519 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.542497e-09 8.343 0 0
DNA methylation R-HSA-5334118 1.764766e-08 7.753 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.148467e-08 7.668 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.560169e-08 7.449 0 0
Axon guidance R-HSA-422475 3.773812e-08 7.423 0 0
Chromatin organization R-HSA-4839726 5.281558e-08 7.277 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.605596e-08 7.251 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.214839e-08 7.207 0 0
Chromatin modifying enzymes R-HSA-3247509 6.008577e-08 7.221 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.316798e-08 7.200 0 0
Meiotic synapsis R-HSA-1221632 8.957491e-08 7.048 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.049611e-07 6.979 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.027095e-07 6.988 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.251024e-07 6.903 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.221835e-07 6.913 0 0
M Phase R-HSA-68886 1.208304e-07 6.918 0 0
Packaging Of Telomere Ends R-HSA-171306 1.536758e-07 6.813 0 0
HATs acetylate histones R-HSA-3214847 1.479005e-07 6.830 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.536758e-07 6.813 0 0
Diseases of programmed cell death R-HSA-9645723 1.669806e-07 6.777 0 0
Meiosis R-HSA-1500620 1.853048e-07 6.732 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.035632e-07 6.691 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.998891e-07 6.699 0 0
Nervous system development R-HSA-9675108 2.082440e-07 6.681 0 0
NRAGE signals death through JNK R-HSA-193648 2.262355e-07 6.645 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.403431e-07 6.468 0 0
Apoptotic execution phase R-HSA-75153 4.211150e-07 6.376 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.425982e-07 6.266 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.425982e-07 6.266 0 0
HDACs deacetylate histones R-HSA-3214815 5.613054e-07 6.251 0 0
Meiotic recombination R-HSA-912446 5.754591e-07 6.240 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.290451e-07 6.137 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.811626e-07 6.107 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.407386e-07 6.027 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.035849e-06 5.985 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.220524e-06 5.913 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.214853e-06 5.915 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.220524e-06 5.913 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.465510e-06 5.834 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.671371e-06 5.777 0 0
Defective pyroptosis R-HSA-9710421 2.006852e-06 5.697 0 0
Mitotic Prophase R-HSA-68875 2.533773e-06 5.596 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.680533e-06 5.572 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.738297e-06 5.563 0 0
Nucleosome assembly R-HSA-774815 3.664153e-06 5.436 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.664153e-06 5.436 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.685774e-06 5.433 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.782088e-06 5.422 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.226290e-06 5.374 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.955609e-06 5.225 0 0
G alpha (12/13) signalling events R-HSA-416482 6.501355e-06 5.187 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.636306e-06 5.178 0 0
Cleavage of the damaged purine R-HSA-110331 9.549639e-06 5.020 0 0
G2/M Checkpoints R-HSA-69481 9.554036e-06 5.020 0 0
Depurination R-HSA-73927 1.296569e-05 4.887 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.403010e-05 4.853 0 0
Signaling by ALK in cancer R-HSA-9700206 1.403010e-05 4.853 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.549170e-05 4.810 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.561533e-05 4.806 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.561533e-05 4.806 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.561533e-05 4.806 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.518091e-05 4.819 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.656315e-05 4.781 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.666899e-05 4.778 0 0
Depyrimidination R-HSA-73928 1.666899e-05 4.778 0 0
Reproduction R-HSA-1474165 1.768043e-05 4.753 0 0
Regulation of TP53 Activity R-HSA-5633007 1.821992e-05 4.739 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.917112e-05 4.717 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.197589e-05 4.658 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.180996e-05 4.661 0 0
mRNA 3'-end processing R-HSA-72187 2.391163e-05 4.621 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.391163e-05 4.621 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.401229e-05 4.620 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.636587e-05 4.579 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.865547e-05 4.543 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.115392e-05 4.506 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.207011e-05 4.494 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.207011e-05 4.494 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.767943e-05 4.424 0 0
ESR-mediated signaling R-HSA-8939211 3.946613e-05 4.404 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.475797e-05 4.349 0 0
mRNA Splicing R-HSA-72172 4.489177e-05 4.348 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.937975e-05 4.306 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.594989e-05 4.181 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.657981e-05 4.116 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.085144e-05 4.092 0 0
DNA Double Strand Break Response R-HSA-5693606 8.569314e-05 4.067 0 0
Estrogen-dependent gene expression R-HSA-9018519 9.980081e-05 4.001 0 0
Homology Directed Repair R-HSA-5693538 1.062536e-04 3.974 0 0
Gene expression (Transcription) R-HSA-74160 1.088269e-04 3.963 0 0
Metalloprotease DUBs R-HSA-5689901 1.182677e-04 3.927 0 0
Deubiquitination R-HSA-5688426 1.320782e-04 3.879 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.363260e-04 3.865 0 0
Gene Silencing by RNA R-HSA-211000 1.602504e-04 3.795 0 0
Mitotic Anaphase R-HSA-68882 1.605100e-04 3.794 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.773701e-04 3.751 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.832249e-04 3.737 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.040769e-04 3.690 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.115432e-04 3.675 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.158785e-04 3.666 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.188322e-04 3.660 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.318396e-04 3.635 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.360676e-04 3.627 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.458642e-04 3.609 0 0
Death Receptor Signaling R-HSA-73887 2.649820e-04 3.577 0 0
Mitotic Prometaphase R-HSA-68877 2.662593e-04 3.575 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.881608e-04 3.540 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.244153e-04 3.489 0 0
Apoptosis R-HSA-109581 3.446972e-04 3.463 0 0
Kinesins R-HSA-983189 3.628084e-04 3.440 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.636071e-04 3.439 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.351990e-04 3.361 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.713835e-04 3.327 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.713835e-04 3.327 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.186194e-04 3.285 0 0
Developmental Biology R-HSA-1266738 5.473746e-04 3.262 0 0
RNA Polymerase II Transcription R-HSA-73857 5.633479e-04 3.249 0 0
RNA Polymerase I Transcription R-HSA-73864 6.005154e-04 3.221 0 0
EPH-Ephrin signaling R-HSA-2682334 6.266637e-04 3.203 0 0
Chromosome Maintenance R-HSA-73886 6.588643e-04 3.181 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.214223e-04 3.207 0 0
Cell-Cell communication R-HSA-1500931 6.287698e-04 3.202 0 0
Ub-specific processing proteases R-HSA-5689880 6.643582e-04 3.178 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.643582e-04 3.178 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.643582e-04 3.178 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.670864e-04 3.176 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.219969e-04 3.141 0 0
PKMTs methylate histone lysines R-HSA-3214841 7.931195e-04 3.101 0 0
Cellular responses to stress R-HSA-2262752 8.339907e-04 3.079 0 0
TCF dependent signaling in response to WNT R-HSA-201681 9.941288e-04 3.003 0 0
Programmed Cell Death R-HSA-5357801 9.268696e-04 3.033 0 0
Cellular responses to stimuli R-HSA-8953897 9.592861e-04 3.018 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.006668e-03 2.997 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.059534e-03 2.975 1 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.187407e-03 2.925 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.187407e-03 2.925 0 0
Telomere Maintenance R-HSA-157579 1.413131e-03 2.850 0 0
Cell junction organization R-HSA-446728 1.495594e-03 2.825 0 0
Oncogene Induced Senescence R-HSA-2559585 1.631803e-03 2.787 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.688088e-03 2.773 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.873267e-03 2.727 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.845043e-03 2.734 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.938995e-03 2.712 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.011952e-03 2.696 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.028011e-03 2.693 0 0
Amyloid fiber formation R-HSA-977225 2.036254e-03 2.691 0 0
Signaling by VEGF R-HSA-194138 2.220243e-03 2.654 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.282168e-03 2.642 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.347028e-03 2.629 0 0
Separation of Sister Chromatids R-HSA-2467813 2.440981e-03 2.612 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.613424e-03 2.583 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.797664e-03 2.553 0 0
Recycling pathway of L1 R-HSA-437239 3.052038e-03 2.515 0 0
HCMV Early Events R-HSA-9609690 3.115315e-03 2.506 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.406397e-03 2.468 0 0
DNA Repair R-HSA-73894 3.375190e-03 2.472 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.481296e-03 2.458 0 0
Signaling by ROBO receptors R-HSA-376176 3.343645e-03 2.476 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.626434e-03 2.441 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.626434e-03 2.441 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.644953e-03 2.438 0 0
Base Excision Repair R-HSA-73884 3.655385e-03 2.437 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.687625e-03 2.433 0 0
Ephrin signaling R-HSA-3928664 3.827452e-03 2.417 0 0
Activation of RAC1 R-HSA-428540 4.059705e-03 2.392 0 0
Netrin-1 signaling R-HSA-373752 4.352380e-03 2.361 0 0
RMTs methylate histone arginines R-HSA-3214858 4.352380e-03 2.361 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.397929e-03 2.357 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.397929e-03 2.357 0 0
Interleukin-12 signaling R-HSA-9020591 4.475650e-03 2.349 0 0
L1CAM interactions R-HSA-373760 4.790734e-03 2.320 0 0
Rap1 signalling R-HSA-392517 5.012769e-03 2.300 0 0
ALK mutants bind TKIs R-HSA-9700645 5.484366e-03 2.261 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.774580e-03 2.238 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.214427e-03 2.283 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.244718e-03 2.204 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.481401e-03 2.188 0 0
Adherens junctions interactions R-HSA-418990 6.957317e-03 2.158 0 0
Semaphorin interactions R-HSA-373755 7.037703e-03 2.153 0 0
Neurodegenerative Diseases R-HSA-8863678 7.088465e-03 2.149 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 7.088465e-03 2.149 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 7.172316e-03 2.144 0 0
Generic Transcription Pathway R-HSA-212436 7.351612e-03 2.134 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.538193e-03 2.123 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 7.821087e-03 2.107 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.821087e-03 2.107 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 7.821087e-03 2.107 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.912548e-03 2.102 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.270857e-03 2.082 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.392110e-03 2.076 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 8.476602e-03 2.072 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 8.476602e-03 2.072 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.022679e-03 2.045 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.879334e-03 2.052 0 0
Nuclear import of Rev protein R-HSA-180746 9.032972e-03 2.044 0 0
Signaling by Hippo R-HSA-2028269 9.386409e-03 2.028 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.902132e-03 2.004 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.045802e-02 1.981 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.130193e-02 1.947 0 0
FOXO-mediated transcription R-HSA-9614085 1.221603e-02 1.913 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.270593e-02 1.896 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.368233e-02 1.864 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.419193e-02 1.848 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.458463e-02 1.836 0 0
Specification of the neural plate border R-HSA-9834899 1.507745e-02 1.822 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.544500e-02 1.811 0 0
Adrenoceptors R-HSA-390696 1.576673e-02 1.802 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.616748e-02 1.791 0 0
Cell-cell junction organization R-HSA-421270 1.681118e-02 1.774 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.742524e-02 1.759 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.742524e-02 1.759 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.756570e-02 1.755 0 0
Interleukin-12 family signaling R-HSA-447115 1.766832e-02 1.753 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.777420e-02 1.750 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.878207e-02 1.726 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.022803e-02 1.694 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.132099e-02 1.671 0 0
Metabolism of RNA R-HSA-8953854 2.000103e-02 1.699 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.132099e-02 1.671 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.022803e-02 1.694 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.189118e-02 1.660 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.189118e-02 1.660 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.223802e-02 1.653 0 0
Activation of BH3-only proteins R-HSA-114452 2.223802e-02 1.653 0 0
Interleukin-37 signaling R-HSA-9008059 2.223802e-02 1.653 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.335283e-02 1.632 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.358369e-02 1.627 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.410583e-02 1.618 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.500837e-02 1.602 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.500837e-02 1.602 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.613292e-02 1.583 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.613292e-02 1.583 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.875544e-02 1.541 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.875544e-02 1.541 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.875544e-02 1.541 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.875544e-02 1.541 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.875544e-02 1.541 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.875544e-02 1.541 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.875544e-02 1.541 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.875544e-02 1.541 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.875544e-02 1.541 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.719273e-02 1.566 0 0
TRP channels R-HSA-3295583 2.719273e-02 1.566 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.049296e-02 1.516 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.817131e-02 1.550 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.837403e-02 1.547 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.987072e-02 1.525 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.681894e-02 1.572 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.719273e-02 1.566 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.951595e-02 1.530 0 0
Signaling by NOTCH R-HSA-157118 2.742220e-02 1.562 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.815860e-02 1.550 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.951595e-02 1.530 0 0
HCMV Late Events R-HSA-9610379 2.647912e-02 1.577 0 0
FLT3 Signaling R-HSA-9607240 2.681894e-02 1.572 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.842453e-02 1.546 0 0
Diseases of DNA repair R-HSA-9675135 2.835798e-02 1.547 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.172279e-02 1.499 0 0
HCMV Infection R-HSA-9609646 3.284712e-02 1.484 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.299495e-02 1.482 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.373295e-02 1.472 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.373295e-02 1.472 0 0
Metabolism of non-coding RNA R-HSA-194441 3.384673e-02 1.470 0 0
snRNP Assembly R-HSA-191859 3.384673e-02 1.470 0 0
Signaling by NTRKs R-HSA-166520 3.415973e-02 1.466 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.449246e-02 1.462 0 0
Integrin signaling R-HSA-354192 3.534251e-02 1.452 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.534251e-02 1.452 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.534251e-02 1.452 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.534251e-02 1.452 0 0
Translation initiation complex formation R-HSA-72649 3.708630e-02 1.431 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.773447e-02 1.423 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.801676e-02 1.420 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.881841e-02 1.411 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.986506e-02 1.399 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.986506e-02 1.399 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.070385e-02 1.390 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.078926e-02 1.389 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.078926e-02 1.389 0 0
DCC mediated attractive signaling R-HSA-418885 4.084337e-02 1.389 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 4.084337e-02 1.389 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.084337e-02 1.389 0 0
Formation of the anterior neural plate R-HSA-9823739 4.084337e-02 1.389 0 0
Regulation of gap junction activity R-HSA-191650 4.516366e-02 1.345 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.516366e-02 1.345 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.516366e-02 1.345 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.910448e-02 1.309 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.910448e-02 1.309 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.874114e-02 1.312 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.874114e-02 1.312 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.874114e-02 1.312 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.874114e-02 1.312 0 0
Signaling by EGFR R-HSA-177929 4.597007e-02 1.338 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.445262e-02 1.352 0 0
Signal amplification R-HSA-392518 4.659688e-02 1.332 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.697302e-02 1.328 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.179538e-02 1.379 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.583666e-02 1.339 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.516366e-02 1.345 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.951093e-02 1.305 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.283951e-02 1.368 0 0
DNA Replication R-HSA-69306 4.702444e-02 1.328 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.292967e-02 1.367 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.859689e-02 1.313 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.997716e-02 1.301 0 0
Signaling by Interleukins R-HSA-449147 5.005917e-02 1.301 0 0
Protein ubiquitination R-HSA-8852135 5.014842e-02 1.300 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.090773e-02 1.293 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.092850e-02 1.293 0 0
Post NMDA receptor activation events R-HSA-438064 5.292204e-02 1.276 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.303884e-02 1.275 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.303884e-02 1.275 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.303884e-02 1.275 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.328881e-02 1.273 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.624440e-02 1.250 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.944804e-02 1.226 0 0
Oligomerization of connexins into connexons R-HSA-190704 5.944804e-02 1.226 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 5.944804e-02 1.226 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 5.944804e-02 1.226 0 0
Transport of connexins along the secretory pathway R-HSA-190827 5.944804e-02 1.226 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 5.944804e-02 1.226 0 0
HIV Life Cycle R-HSA-162587 5.964743e-02 1.224 0 0
Disorders of Developmental Biology R-HSA-9675151 6.030620e-02 1.220 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.030620e-02 1.220 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.094573e-02 1.215 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 6.119600e-02 1.213 0 0
Disorders of Nervous System Development R-HSA-9697154 6.119600e-02 1.213 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.119600e-02 1.213 0 0
Pervasive developmental disorders R-HSA-9005895 6.119600e-02 1.213 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.119600e-02 1.213 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 6.119600e-02 1.213 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 6.119600e-02 1.213 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 6.119600e-02 1.213 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 6.119600e-02 1.213 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 6.119600e-02 1.213 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 6.119600e-02 1.213 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 6.136288e-02 1.212 0 0
Signaling by WNT R-HSA-195721 6.368371e-02 1.196 1 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.531770e-02 1.185 0 0
AURKA Activation by TPX2 R-HSA-8854518 6.709944e-02 1.173 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 6.742065e-02 1.171 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.448085e-02 1.128 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 7.482189e-02 1.126 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.178929e-02 1.144 0 0
Notch-HLH transcription pathway R-HSA-350054 7.817012e-02 1.107 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.817012e-02 1.107 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.184202e-02 1.144 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 7.444429e-02 1.128 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.856287e-02 1.164 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.263900e-02 1.083 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.013142e-02 1.154 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.380485e-02 1.077 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.444429e-02 1.128 0 0
Adipogenesis R-HSA-9843745 7.968427e-02 1.099 0 0
Gap junction trafficking and regulation R-HSA-157858 7.605230e-02 1.119 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.815273e-02 1.167 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 6.762403e-02 1.170 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.444429e-02 1.128 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.482189e-02 1.126 0 0
GPER1 signaling R-HSA-9634597 6.882486e-02 1.162 0 0
Calcineurin activates NFAT R-HSA-2025928 7.448085e-02 1.128 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.443877e-02 1.073 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.380485e-02 1.077 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.798136e-02 1.168 0 0
mTORC1-mediated signalling R-HSA-166208 7.817012e-02 1.107 0 0
Pyroptosis R-HSA-5620971 8.187137e-02 1.087 0 0
Polo-like kinase mediated events R-HSA-156711 8.443877e-02 1.073 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.934944e-02 1.159 0 0
G2/M Transition R-HSA-69275 7.155906e-02 1.145 0 0
Heme signaling R-HSA-9707616 8.123448e-02 1.090 0 0
Specification of primordial germ cells R-HSA-9827857 7.178929e-02 1.144 0 0
MAPK family signaling cascades R-HSA-5683057 8.501190e-02 1.071 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.842432e-02 1.053 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.844073e-02 1.053 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.886403e-02 1.051 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.985881e-02 1.046 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 8.985881e-02 1.046 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 8.995268e-02 1.046 0 0
Signal regulatory protein family interactions R-HSA-391160 8.995268e-02 1.046 0 0
UCH proteinases R-HSA-5689603 9.101382e-02 1.041 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.225410e-01 0.912 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.225410e-01 0.912 0 0
KIT mutants bind TKIs R-HSA-9669921 1.225410e-01 0.912 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.225410e-01 0.912 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.225410e-01 0.912 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.225410e-01 0.912 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.225410e-01 0.912 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.225410e-01 0.912 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.225410e-01 0.912 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.225410e-01 0.912 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.225410e-01 0.912 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.225410e-01 0.912 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.225410e-01 0.912 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.225410e-01 0.912 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.225410e-01 0.912 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.225410e-01 0.912 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.225410e-01 0.912 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.225410e-01 0.912 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.225410e-01 0.912 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.225410e-01 0.912 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.225410e-01 0.912 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 9.720315e-02 1.012 0 0
Regulation of TP53 Expression R-HSA-6804754 9.720315e-02 1.012 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 9.720315e-02 1.012 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 9.720315e-02 1.012 0 0
Diseases of cellular response to stress R-HSA-9675132 9.720315e-02 1.012 0 0
Diseases of Cellular Senescence R-HSA-9630747 9.720315e-02 1.012 0 0
Potassium transport channels R-HSA-1296067 9.720315e-02 1.012 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 9.720315e-02 1.012 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 9.720315e-02 1.012 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 9.720315e-02 1.012 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 9.720315e-02 1.012 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 9.720315e-02 1.012 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 9.720315e-02 1.012 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 9.720315e-02 1.012 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 9.720315e-02 1.012 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 9.720315e-02 1.012 0 0
CREB phosphorylation R-HSA-199920 1.154055e-01 0.938 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 9.301709e-02 1.031 0 0
Signaling by APC mutants R-HSA-4839744 1.135083e-01 0.945 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.135083e-01 0.945 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.135083e-01 0.945 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.135083e-01 0.945 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.065363e-01 0.973 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.065363e-01 0.973 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.131496e-01 0.946 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.131496e-01 0.946 0 0
Deadenylation of mRNA R-HSA-429947 1.024751e-01 0.989 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.024751e-01 0.989 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.024751e-01 0.989 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.159991e-01 0.936 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.159991e-01 0.936 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.159991e-01 0.936 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.042786e-01 0.982 0 0
RAF activation R-HSA-5673000 9.383917e-02 1.028 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.143138e-01 0.942 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.005424e-01 0.998 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.096442e-01 0.960 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.216088e-02 1.035 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.171679e-01 0.931 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.128547e-01 0.947 0 0
HDMs demethylate histones R-HSA-3214842 1.159991e-01 0.936 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 9.315515e-02 1.031 0 0
Signaling by ERBB2 R-HSA-1227986 1.158402e-01 0.936 0 0
Receptor Mediated Mitophagy R-HSA-8934903 9.301709e-02 1.031 0 0
MHC class II antigen presentation R-HSA-2132295 9.623687e-02 1.017 0 0
Regulation of CDH11 function R-HSA-9762292 9.301709e-02 1.031 0 0
Peptide chain elongation R-HSA-156902 9.216088e-02 1.035 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.089621e-01 0.963 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.116515e-01 0.952 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.211624e-01 0.917 0 0
Interleukin-2 signaling R-HSA-9020558 1.135083e-01 0.945 0 0
Signalling to ERKs R-HSA-187687 1.045433e-01 0.981 0 0
Long-term potentiation R-HSA-9620244 1.159991e-01 0.936 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.623687e-02 1.017 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.037496e-01 0.984 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.129232e-01 0.947 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.021033e-01 0.991 0 0
Signaling by TGFBR3 R-HSA-9839373 1.023973e-01 0.990 0 0
Co-stimulation by CD28 R-HSA-389356 1.224351e-01 0.912 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.024751e-01 0.989 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 9.275437e-02 1.033 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 9.315515e-02 1.031 0 0
Signaling by Leptin R-HSA-2586552 9.301709e-02 1.031 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.038042e-01 0.984 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.572668e-02 1.019 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.383917e-02 1.028 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.244658e-01 0.905 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.245009e-01 0.905 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.258242e-01 0.900 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.263285e-01 0.898 1 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.279238e-01 0.893 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.281018e-01 0.892 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.303598e-01 0.885 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.304026e-01 0.885 0 0
Myogenesis R-HSA-525793 1.304026e-01 0.885 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.305752e-01 0.884 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.315878e-01 0.881 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.332172e-01 0.875 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.332172e-01 0.875 0 0
Centrosome maturation R-HSA-380287 1.346889e-01 0.871 0 0
Co-inhibition by PD-1 R-HSA-389948 1.356079e-01 0.868 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.357902e-01 0.867 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.357902e-01 0.867 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.357902e-01 0.867 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.357902e-01 0.867 0 0
Signaling by AXIN mutants R-HSA-4839735 1.357902e-01 0.867 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.357902e-01 0.867 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.397171e-01 0.855 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.398306e-01 0.854 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.398306e-01 0.854 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.398306e-01 0.854 0 0
Axonal growth stimulation R-HSA-209563 1.398306e-01 0.854 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.398306e-01 0.854 0 0
Cardiogenesis R-HSA-9733709 1.435684e-01 0.843 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.437575e-01 0.842 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.437575e-01 0.842 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.445013e-01 0.840 0 0
Netrin mediated repulsion signals R-HSA-418886 1.445013e-01 0.840 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.445013e-01 0.840 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.445013e-01 0.840 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.445013e-01 0.840 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 1.445013e-01 0.840 0 0
Regulation of PTEN localization R-HSA-8948747 1.445013e-01 0.840 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.451572e-01 0.838 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.451572e-01 0.838 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.451572e-01 0.838 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.456503e-01 0.837 0 0
Glycolysis R-HSA-70171 1.469097e-01 0.833 0 0
G1 Phase R-HSA-69236 1.492367e-01 0.826 0 0
Cyclin D associated events in G1 R-HSA-69231 1.492367e-01 0.826 0 0
Gap junction trafficking R-HSA-190828 1.492367e-01 0.826 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.509194e-01 0.821 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.531127e-01 0.815 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.300719e-01 0.638 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.300719e-01 0.638 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.300719e-01 0.638 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.300719e-01 0.638 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.300719e-01 0.638 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.300719e-01 0.638 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.855706e-01 0.731 0 0
NADE modulates death signalling R-HSA-205025 1.855706e-01 0.731 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.855706e-01 0.731 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.855706e-01 0.731 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.855706e-01 0.731 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.855706e-01 0.731 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.855706e-01 0.731 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.855706e-01 0.731 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.330211e-01 0.633 0 0
IRS activation R-HSA-74713 2.330211e-01 0.633 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.330211e-01 0.633 0 0
G2 Phase R-HSA-68911 2.330211e-01 0.633 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.330211e-01 0.633 0 0
Type I hemidesmosome assembly R-HSA-446107 1.756943e-01 0.755 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.756943e-01 0.755 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.756943e-01 0.755 0 0
Formation of annular gap junctions R-HSA-196025 1.756943e-01 0.755 0 0
FGFR1b ligand binding and activation R-HSA-190370 1.756943e-01 0.755 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.756943e-01 0.755 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.596751e-01 0.797 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.596751e-01 0.797 0 0
ARMS-mediated activation R-HSA-170984 2.085317e-01 0.681 0 0
Gap junction degradation R-HSA-190873 2.085317e-01 0.681 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.085317e-01 0.681 0 0
Regulation of KIT signaling R-HSA-1433559 2.114334e-01 0.675 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.114334e-01 0.675 0 0
Striated Muscle Contraction R-HSA-390522 1.580893e-01 0.801 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.580893e-01 0.801 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.025899e-01 0.693 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.025899e-01 0.693 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.314991e-01 0.635 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.732703e-01 0.761 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.960089e-01 0.708 0 0
Downstream signal transduction R-HSA-186763 2.141571e-01 0.669 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.141571e-01 0.669 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.751937e-01 0.756 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.751937e-01 0.756 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.751937e-01 0.756 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.751937e-01 0.756 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.328876e-01 0.633 0 0
MAP2K and MAPK activation R-HSA-5674135 1.970212e-01 0.705 0 0
Voltage gated Potassium channels R-HSA-1296072 2.223789e-01 0.653 0 0
G alpha (z) signalling events R-HSA-418597 2.077862e-01 0.682 1 1
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.572156e-01 0.804 0 0
EGFR downregulation R-HSA-182971 2.141571e-01 0.669 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.676769e-01 0.776 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.676769e-01 0.776 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.306726e-01 0.637 0 0
TGFBR3 expression R-HSA-9839394 2.229596e-01 0.652 0 0
Transcription of the HIV genome R-HSA-167172 2.018466e-01 0.695 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.085317e-01 0.681 0 0
Gap junction assembly R-HSA-190861 1.732703e-01 0.761 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.855706e-01 0.731 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.642033e-01 0.785 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.085317e-01 0.681 0 0
Signaling by RAS mutants R-HSA-6802949 1.751937e-01 0.756 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.188891e-01 0.660 1 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.330211e-01 0.633 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.596751e-01 0.797 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.314732e-01 0.635 0 0
Mitochondrial biogenesis R-HSA-1592230 2.023886e-01 0.694 0 0
Circadian clock R-HSA-9909396 1.700433e-01 0.769 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.820841e-01 0.740 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.330211e-01 0.633 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.114334e-01 0.675 0 0
DARPP-32 events R-HSA-180024 1.785040e-01 0.748 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.732703e-01 0.761 0 0
Aggrephagy R-HSA-9646399 1.676769e-01 0.776 0 0
HIV Infection R-HSA-162906 2.236420e-01 0.650 0 0
Opioid Signalling R-HSA-111885 1.821033e-01 0.740 1 0
Cilium Assembly R-HSA-5617833 2.071449e-01 0.684 0 0
G-protein mediated events R-HSA-112040 1.897801e-01 0.722 1 0
Membrane Trafficking R-HSA-199991 2.186683e-01 0.660 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.085317e-01 0.681 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.849602e-01 0.733 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.213111e-01 0.655 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.599978e-01 0.796 0 0
DNA Damage Bypass R-HSA-73893 2.177119e-01 0.662 0 0
Signaling by NOTCH1 R-HSA-1980143 2.164243e-01 0.665 0 0
Signaling by LTK R-HSA-9842663 1.596751e-01 0.797 0 0
Eukaryotic Translation Termination R-HSA-72764 1.620061e-01 0.790 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.212892e-01 0.655 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.330211e-01 0.633 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.212892e-01 0.655 0 0
MTOR signalling R-HSA-165159 2.124549e-01 0.673 0 0
Muscle contraction R-HSA-397014 2.188891e-01 0.660 0 0
NGF-stimulated transcription R-HSA-9031628 2.030958e-01 0.692 0 0
Signaling by PTK6 R-HSA-8848021 2.247021e-01 0.648 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.247021e-01 0.648 0 0
Inhibition of PKR R-HSA-169131 2.300719e-01 0.638 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.855706e-01 0.731 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.330211e-01 0.633 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.756943e-01 0.755 0 0
Unwinding of DNA R-HSA-176974 2.085317e-01 0.681 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.085317e-01 0.681 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.619604e-01 0.791 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.094625e-01 0.679 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.700433e-01 0.769 0 0
Cellular response to heat stress R-HSA-3371556 1.765715e-01 0.753 0 0
Host Interactions of HIV factors R-HSA-162909 2.027082e-01 0.693 0 0
Apoptotic factor-mediated response R-HSA-111471 1.857244e-01 0.731 0 0
Formation of definitive endoderm R-HSA-9823730 2.314991e-01 0.635 0 0
tRNA processing in the nucleus R-HSA-6784531 2.114253e-01 0.675 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.849602e-01 0.733 0 0
Inositol phosphate metabolism R-HSA-1483249 2.018874e-01 0.695 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.330211e-01 0.633 0 0
Selenocysteine synthesis R-HSA-2408557 2.208029e-01 0.656 0 0
Co-inhibition by BTLA R-HSA-9927353 2.330211e-01 0.633 0 0
NrCAM interactions R-HSA-447038 2.330211e-01 0.633 0 0
Sodium/Proton exchangers R-HSA-425986 1.756943e-01 0.755 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.110571e-01 0.676 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.751937e-01 0.756 0 0
Influenza Infection R-HSA-168255 1.788997e-01 0.747 0 0
PTEN Regulation R-HSA-6807070 2.386058e-01 0.622 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.388800e-01 0.622 0 0
p75NTR signals via NF-kB R-HSA-193639 2.388800e-01 0.622 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.388800e-01 0.622 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.388800e-01 0.622 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.418727e-01 0.616 0 0
Viral mRNA Translation R-HSA-192823 2.422840e-01 0.616 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.425792e-01 0.615 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.425792e-01 0.615 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.425792e-01 0.615 0 0
Signal attenuation R-HSA-74749 2.425792e-01 0.615 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 2.439645e-01 0.613 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.510589e-01 0.600 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.510589e-01 0.600 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.521368e-01 0.598 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.244307e-01 0.489 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.244307e-01 0.489 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.244307e-01 0.489 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.244307e-01 0.489 0 0
Mitochondrial transcription initiation R-HSA-163282 3.244307e-01 0.489 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.244307e-01 0.489 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.244307e-01 0.489 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.244307e-01 0.489 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.244307e-01 0.489 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.244307e-01 0.489 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.244307e-01 0.489 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.244307e-01 0.489 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.244307e-01 0.489 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.244307e-01 0.489 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.244307e-01 0.489 0 0
Intestinal infectious diseases R-HSA-8942233 3.244307e-01 0.489 0 0
MPS IIID - Sanfilippo syndrome D R-HSA-2206305 3.244307e-01 0.489 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.244307e-01 0.489 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.244307e-01 0.489 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.810766e-01 0.551 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.810766e-01 0.551 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.810766e-01 0.551 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.810766e-01 0.551 0 0
Phosphorylation of Emi1 R-HSA-176417 2.810766e-01 0.551 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.072300e-01 0.390 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.072300e-01 0.390 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.072300e-01 0.390 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.072300e-01 0.390 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.072300e-01 0.390 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.288768e-01 0.483 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.288768e-01 0.483 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.288768e-01 0.483 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.774304e-01 0.557 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.774304e-01 0.557 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 2.774304e-01 0.557 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.670868e-01 0.573 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.127137e-01 0.505 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.127137e-01 0.505 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.757629e-01 0.425 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.757629e-01 0.425 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.757629e-01 0.425 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.757629e-01 0.425 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.757629e-01 0.425 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.757629e-01 0.425 0 0
SOS-mediated signalling R-HSA-112412 3.757629e-01 0.425 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.798856e-01 0.319 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.798856e-01 0.319 0 0
Classical Kir channels R-HSA-1296053 4.798856e-01 0.319 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.798856e-01 0.319 0 0
MET activates PTPN11 R-HSA-8865999 4.798856e-01 0.319 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.798856e-01 0.319 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.798856e-01 0.319 0 0
Invadopodia formation R-HSA-8941237 4.798856e-01 0.319 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.798856e-01 0.319 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.554949e-01 0.593 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.480950e-01 0.458 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.480950e-01 0.458 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.800552e-01 0.553 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.800552e-01 0.553 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.800552e-01 0.553 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.655153e-01 0.576 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.655153e-01 0.576 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.655153e-01 0.576 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.249612e-01 0.488 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.249612e-01 0.488 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.212412e-01 0.375 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.212412e-01 0.375 0 0
Activation of RAS in B cells R-HSA-1169092 4.212412e-01 0.375 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.875216e-01 0.541 0 0
HIV elongation arrest and recovery R-HSA-167287 2.875216e-01 0.541 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.875216e-01 0.541 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.832794e-01 0.416 0 0
Formation of axial mesoderm R-HSA-9796292 3.832794e-01 0.416 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.832794e-01 0.416 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.542439e-01 0.451 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.542439e-01 0.451 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.098928e-01 0.509 0 0
Activation of the pre-replicative complex R-HSA-68962 3.325396e-01 0.478 0 0
Thromboxane signalling through TP receptor R-HSA-428930 3.558417e-01 0.449 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.180111e-01 0.379 0 0
cGMP effects R-HSA-418457 4.180111e-01 0.379 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.649527e-01 0.333 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.649527e-01 0.333 0 0
WNT mediated activation of DVL R-HSA-201688 4.649527e-01 0.333 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 4.126342e-01 0.384 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.520721e-01 0.345 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.520721e-01 0.345 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.520721e-01 0.345 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.491932e-01 0.457 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.012712e-01 0.397 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 4.414391e-01 0.355 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.414391e-01 0.355 0 0
MAPK3 (ERK1) activation R-HSA-110056 5.066474e-01 0.295 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.066474e-01 0.295 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.066474e-01 0.295 0 0
Stabilization of p53 R-HSA-69541 3.958148e-01 0.403 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.958148e-01 0.403 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.322886e-01 0.364 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 4.852799e-01 0.314 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 4.852799e-01 0.314 0 0
Phase 4 - resting membrane potential R-HSA-5576886 4.852799e-01 0.314 0 0
HIV Transcription Elongation R-HSA-167169 4.168292e-01 0.380 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.168292e-01 0.380 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.168292e-01 0.380 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.168292e-01 0.380 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.698076e-01 0.328 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.698076e-01 0.328 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.469483e-01 0.350 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.295694e-01 0.367 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.822321e-01 0.317 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.918399e-01 0.308 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.066380e-01 0.295 0 0
PPARA activates gene expression R-HSA-1989781 4.127786e-01 0.384 0 0
Signaling by NOTCH4 R-HSA-9013694 5.064104e-01 0.295 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 4.345308e-01 0.362 0 0
PKR-mediated signaling R-HSA-9833482 3.672885e-01 0.435 0 0
Protein folding R-HSA-391251 4.636891e-01 0.334 0 0
RNA Polymerase III Transcription R-HSA-74158 4.918399e-01 0.308 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.822321e-01 0.317 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.066380e-01 0.295 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.069158e-01 0.390 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.773797e-01 0.423 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.012712e-01 0.397 0 0
G-protein beta:gamma signalling R-HSA-397795 4.012712e-01 0.397 0 0
Signaling by FGFR3 R-HSA-5654741 3.905731e-01 0.408 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.050502e-01 0.516 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.542439e-01 0.451 0 0
Signaling by FGFR4 R-HSA-5654743 3.516899e-01 0.454 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.542439e-01 0.451 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.804508e-01 0.318 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.126342e-01 0.384 0 0
Ribosome-associated quality control R-HSA-9948299 3.782733e-01 0.422 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.958466e-01 0.529 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.867136e-01 0.543 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.649527e-01 0.333 0 0
Activation of GABAB receptors R-HSA-991365 3.324150e-01 0.478 0 0
Signaling by FGFR1 R-HSA-5654736 4.585229e-01 0.339 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.918399e-01 0.308 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.180111e-01 0.379 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.133200e-01 0.504 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.414391e-01 0.355 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.142989e-01 0.383 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.212412e-01 0.375 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.813992e-01 0.419 0 0
IGF1R signaling cascade R-HSA-2428924 4.668175e-01 0.331 0 0
GAB1 signalosome R-HSA-180292 3.542439e-01 0.451 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.810766e-01 0.551 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.757629e-01 0.425 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 4.520721e-01 0.345 0 0
Signalling to RAS R-HSA-167044 4.414391e-01 0.355 0 0
PI3K/AKT activation R-HSA-198203 5.066474e-01 0.295 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.241744e-01 0.372 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.741667e-01 0.324 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.325396e-01 0.478 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.469483e-01 0.350 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.655153e-01 0.576 0 0
GABA B receptor activation R-HSA-977444 3.324150e-01 0.478 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.311948e-01 0.480 0 0
NF-kB is activated and signals survival R-HSA-209560 3.127137e-01 0.505 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 4.414391e-01 0.355 0 0
GABA receptor activation R-HSA-977443 3.979426e-01 0.400 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.838697e-01 0.315 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.352935e-01 0.361 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.806610e-01 0.552 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.806610e-01 0.552 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.806610e-01 0.552 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.806610e-01 0.552 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 4.852799e-01 0.314 0 0
Neurexins and neuroligins R-HSA-6794361 3.855441e-01 0.414 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.672885e-01 0.435 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.810766e-01 0.551 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.072300e-01 0.390 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.127137e-01 0.505 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.212412e-01 0.375 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.212412e-01 0.375 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.212412e-01 0.375 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.875216e-01 0.541 0 0
FGFR1c ligand binding and activation R-HSA-190373 3.832794e-01 0.416 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.613702e-01 0.583 0 0
Killing mechanisms R-HSA-9664420 4.852799e-01 0.314 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.852799e-01 0.314 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.538107e-01 0.595 0 0
S Phase R-HSA-69242 4.180628e-01 0.379 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.241744e-01 0.372 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.958466e-01 0.529 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.835212e-01 0.416 0 0
Signal transduction by L1 R-HSA-445144 4.126342e-01 0.384 0 0
Prolonged ERK activation events R-HSA-169893 2.670868e-01 0.573 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.480950e-01 0.458 0 0
Signaling by WNT in cancer R-HSA-4791275 3.783120e-01 0.422 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.852799e-01 0.314 0 0
HSF1-dependent transactivation R-HSA-3371571 5.064353e-01 0.295 0 0
Hedgehog 'off' state R-HSA-5610787 4.836421e-01 0.315 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.387064e-01 0.470 0 0
Neuronal System R-HSA-112316 4.629006e-01 0.335 1 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.810766e-01 0.551 0 0
p38MAPK events R-HSA-171007 4.520721e-01 0.345 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.012712e-01 0.397 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.066474e-01 0.295 0 0
Degradation of CDH1 R-HSA-9766229 4.683040e-01 0.329 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.098928e-01 0.509 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.377807e-01 0.359 0 0
Interleukin-2 family signaling R-HSA-451927 4.168292e-01 0.380 0 0
Potassium Channels R-HSA-1296071 3.290344e-01 0.483 0 0
Cardiac conduction R-HSA-5576891 3.713057e-01 0.430 0 0
rRNA processing R-HSA-72312 4.498081e-01 0.347 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.698076e-01 0.328 0 0
Adaptive Immune System R-HSA-1280218 3.263113e-01 0.486 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.133200e-01 0.504 0 0
Ion homeostasis R-HSA-5578775 4.585229e-01 0.339 0 0
Calmodulin induced events R-HSA-111933 4.918399e-01 0.308 1 1
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.561271e-01 0.448 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.378783e-01 0.471 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.244307e-01 0.489 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.072300e-01 0.390 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.072300e-01 0.390 0 0
Negative regulation of FLT3 R-HSA-9706369 2.670868e-01 0.573 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.757629e-01 0.425 0 0
RET signaling R-HSA-8853659 3.329908e-01 0.478 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.538334e-01 0.451 0 0
Intraflagellar transport R-HSA-5620924 4.489916e-01 0.348 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.822321e-01 0.317 0 0
Platelet calcium homeostasis R-HSA-418360 4.822321e-01 0.317 0 0
CaM pathway R-HSA-111997 4.918399e-01 0.308 1 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.806610e-01 0.552 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.069158e-01 0.390 0 0
Amine ligand-binding receptors R-HSA-375280 3.710928e-01 0.431 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.295694e-01 0.367 0 0
Frs2-mediated activation R-HSA-170968 3.832794e-01 0.416 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.324150e-01 0.478 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.288543e-01 0.368 0 0
The NLRP3 inflammasome R-HSA-844456 3.835212e-01 0.416 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.288543e-01 0.368 0 0
Regulated Necrosis R-HSA-5218859 4.087834e-01 0.389 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.028501e-01 0.395 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.621436e-01 0.335 0 0
Suppression of apoptosis R-HSA-9635465 2.774304e-01 0.557 0 0
PECAM1 interactions R-HSA-210990 2.774304e-01 0.557 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.212412e-01 0.375 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.322886e-01 0.364 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.945437e-01 0.306 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.698076e-01 0.328 0 0
Interleukin-1 family signaling R-HSA-446652 4.625760e-01 0.335 0 0
Selective autophagy R-HSA-9663891 3.917080e-01 0.407 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.249612e-01 0.488 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.212412e-01 0.375 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.212412e-01 0.375 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.649527e-01 0.333 0 0
Interleukin-1 processing R-HSA-448706 4.649527e-01 0.333 0 0
Protein hydroxylation R-HSA-9629569 4.126342e-01 0.384 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.976270e-01 0.303 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.324516e-01 0.364 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.066474e-01 0.295 0 0
Stimuli-sensing channels R-HSA-2672351 4.028501e-01 0.395 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.973764e-01 0.303 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.654344e-01 0.576 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.654344e-01 0.576 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.654344e-01 0.576 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.471698e-01 0.459 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.168292e-01 0.380 0 0
Diseases of Immune System R-HSA-5260271 4.168292e-01 0.380 0 0
TBC/RABGAPs R-HSA-8854214 4.997193e-01 0.301 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.158419e-01 0.381 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.810766e-01 0.551 0 0
DSCAM interactions R-HSA-376172 4.072300e-01 0.390 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.127137e-01 0.505 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.798856e-01 0.319 0 0
Maturation of nucleoprotein R-HSA-9683610 3.832794e-01 0.416 0 0
Platelet sensitization by LDL R-HSA-432142 3.542439e-01 0.451 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.542439e-01 0.451 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.220922e-01 0.375 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.151990e-01 0.382 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.655153e-01 0.576 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.012712e-01 0.397 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.101152e-01 0.387 0 0
Sensory processing of sound R-HSA-9659379 3.525037e-01 0.453 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.678743e-01 0.330 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.554949e-01 0.593 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.288768e-01 0.483 0 0
Histamine receptors R-HSA-390650 4.798856e-01 0.319 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.649527e-01 0.333 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 4.087834e-01 0.389 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.415552e-01 0.355 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.798856e-01 0.319 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.798856e-01 0.319 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.012712e-01 0.397 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.698076e-01 0.328 0 0
Signaling by ALK R-HSA-201556 3.958148e-01 0.403 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.585229e-01 0.339 0 0
Cytoprotection by HMOX1 R-HSA-9707564 4.120635e-01 0.385 0 0
IRE1alpha activates chaperones R-HSA-381070 3.454639e-01 0.462 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.835212e-01 0.416 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.520721e-01 0.345 0 0
Glucose metabolism R-HSA-70326 3.560695e-01 0.448 0 0
Interleukin-7 signaling R-HSA-1266695 3.813992e-01 0.419 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.542439e-01 0.451 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.758974e-01 0.322 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.525037e-01 0.453 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.631199e-01 0.440 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 3.832794e-01 0.416 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.587678e-01 0.587 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.180111e-01 0.379 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.138361e-01 0.289 0 0
Gastrulation R-HSA-9758941 5.143047e-01 0.289 0 0
Phase 2 - plateau phase R-HSA-5576893 5.174856e-01 0.286 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.174856e-01 0.286 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.174856e-01 0.286 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.174856e-01 0.286 0 0
Hemostasis R-HSA-109582 5.231618e-01 0.281 1 0
Interleukin receptor SHC signaling R-HSA-912526 5.247995e-01 0.280 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 5.247995e-01 0.280 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 5.247995e-01 0.280 0 0
Growth hormone receptor signaling R-HSA-982772 5.247995e-01 0.280 0 0
Cellular response to starvation R-HSA-9711097 5.287645e-01 0.277 0 0
Trafficking of AMPA receptors R-HSA-399719 5.305709e-01 0.275 1 0
SARS-CoV-2 Infection R-HSA-9694516 5.335498e-01 0.273 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.345386e-01 0.272 0 0
DAG and IP3 signaling R-HSA-1489509 5.397688e-01 0.268 1 0
Nucleotide catabolism defects R-HSA-9735786 5.436394e-01 0.265 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.436394e-01 0.265 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.436394e-01 0.265 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 5.436394e-01 0.265 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.436394e-01 0.265 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.436394e-01 0.265 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.436394e-01 0.265 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.436394e-01 0.265 0 0
Dopamine receptors R-HSA-390651 5.436394e-01 0.265 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.436394e-01 0.265 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.436394e-01 0.265 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.436602e-01 0.265 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.461631e-01 0.263 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.461631e-01 0.263 0 0
Formation of the posterior neural plate R-HSA-9832991 5.461631e-01 0.263 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.461631e-01 0.263 0 0
Prostanoid ligand receptors R-HSA-391908 5.461631e-01 0.263 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.461631e-01 0.263 0 0
PLC beta mediated events R-HSA-112043 5.472343e-01 0.262 1 0
MAP kinase activation R-HSA-450294 5.472343e-01 0.262 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.485706e-01 0.261 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.485706e-01 0.261 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.512420e-01 0.259 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.512420e-01 0.259 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.536744e-01 0.257 0 0
G0 and Early G1 R-HSA-1538133 5.539693e-01 0.257 0 0
DNA strand elongation R-HSA-69190 5.539693e-01 0.257 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.592954e-01 0.252 0 0
Toll-like Receptor Cascades R-HSA-168898 5.605350e-01 0.251 0 0
Regulation of insulin secretion R-HSA-422356 5.620907e-01 0.250 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.643249e-01 0.248 0 0
Signaling by PDGF R-HSA-186797 5.643249e-01 0.248 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.667241e-01 0.247 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.767801e-01 0.239 1 0
Formation of the nephric duct R-HSA-9830364 5.768854e-01 0.239 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.768854e-01 0.239 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.784439e-01 0.238 0 0
PKA activation in glucagon signalling R-HSA-164378 5.784439e-01 0.238 0 0
Mismatch Repair R-HSA-5358508 5.784439e-01 0.238 0 0
PKA activation R-HSA-163615 5.784439e-01 0.238 0 0
FGFR1 ligand binding and activation R-HSA-190242 5.784439e-01 0.238 0 0
Tie2 Signaling R-HSA-210993 5.784439e-01 0.238 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.834075e-01 0.234 0 0
Integration of provirus R-HSA-162592 5.834075e-01 0.234 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.834075e-01 0.234 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.834075e-01 0.234 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.834075e-01 0.234 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.834075e-01 0.234 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.834075e-01 0.234 0 0
Macroautophagy R-HSA-1632852 5.874008e-01 0.231 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 5.874061e-01 0.231 0 0
G alpha (s) signalling events R-HSA-418555 5.944443e-01 0.226 0 0
G alpha (q) signalling events R-HSA-416476 5.964176e-01 0.224 0 0
TNF signaling R-HSA-75893 5.972384e-01 0.224 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.983004e-01 0.223 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.989578e-01 0.223 0 0
Signaling by FGFR2 R-HSA-5654738 5.991248e-01 0.222 0 0
Activation of AMPA receptors R-HSA-399710 5.995818e-01 0.222 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.995818e-01 0.222 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.995818e-01 0.222 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.995818e-01 0.222 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.995818e-01 0.222 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.995818e-01 0.222 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.995818e-01 0.222 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.995818e-01 0.222 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.995818e-01 0.222 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.995818e-01 0.222 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.995818e-01 0.222 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.016734e-01 0.221 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.070392e-01 0.217 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.070392e-01 0.217 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.070392e-01 0.217 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.070392e-01 0.217 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.070392e-01 0.217 0 0
Maturation of nucleoprotein R-HSA-9694631 6.070392e-01 0.217 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.070392e-01 0.217 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.095163e-01 0.215 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.120401e-01 0.213 0 0
Regulation of CDH1 Function R-HSA-9764561 6.143890e-01 0.212 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.146081e-01 0.211 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.152226e-01 0.211 0 0
PI Metabolism R-HSA-1483255 6.152226e-01 0.211 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.173661e-01 0.209 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.173661e-01 0.209 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.183437e-01 0.209 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.183437e-01 0.209 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.183437e-01 0.209 0 0
Regulation of IFNG signaling R-HSA-877312 6.183437e-01 0.209 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.183437e-01 0.209 0 0
OAS antiviral response R-HSA-8983711 6.183437e-01 0.209 0 0
Integration of energy metabolism R-HSA-163685 6.194109e-01 0.208 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.204645e-01 0.207 0 0
Mitophagy R-HSA-5205647 6.204645e-01 0.207 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.204645e-01 0.207 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.255621e-01 0.204 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.255621e-01 0.204 0 0
Signaling by ERBB4 R-HSA-1236394 6.287463e-01 0.202 0 0
Cellular response to chemical stress R-HSA-9711123 6.292185e-01 0.201 0 0
Transmission across Chemical Synapses R-HSA-112315 6.298737e-01 0.201 1 0
Signaling by TGFB family members R-HSA-9006936 6.326128e-01 0.199 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.343119e-01 0.198 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.343119e-01 0.198 0 0
Nephrin family interactions R-HSA-373753 6.343119e-01 0.198 0 0
Ca-dependent events R-HSA-111996 6.365222e-01 0.196 1 0
Rab regulation of trafficking R-HSA-9007101 6.405156e-01 0.193 0 0
Signaling by Hedgehog R-HSA-5358351 6.412695e-01 0.193 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.412697e-01 0.193 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.412697e-01 0.193 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.412697e-01 0.193 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.474999e-01 0.189 0 0
Telomere Extension By Telomerase R-HSA-171319 6.485184e-01 0.188 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.485184e-01 0.188 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.485184e-01 0.188 0 0
Inflammasomes R-HSA-622312 6.485184e-01 0.188 0 0
Plus-strand DNA synthesis R-HSA-164525 6.486694e-01 0.188 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.486694e-01 0.188 0 0
PKB-mediated events R-HSA-109703 6.486694e-01 0.188 0 0
PDE3B signalling R-HSA-165160 6.486694e-01 0.188 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.486694e-01 0.188 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.486694e-01 0.188 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.486694e-01 0.188 0 0
Signaling by MAPK mutants R-HSA-9652817 6.486694e-01 0.188 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.486694e-01 0.188 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.486694e-01 0.188 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.486694e-01 0.188 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.486694e-01 0.188 0 0
Formation of the Editosome R-HSA-75094 6.486694e-01 0.188 0 0
Ceramide signalling R-HSA-193681 6.486694e-01 0.188 0 0
Synthesis of PS R-HSA-1483101 6.486694e-01 0.188 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.486694e-01 0.188 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 6.486694e-01 0.188 0 0
VEGF ligand-receptor interactions R-HSA-194313 6.486694e-01 0.188 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.486694e-01 0.188 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.486694e-01 0.188 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.486694e-01 0.188 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.486694e-01 0.188 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.486694e-01 0.188 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.486694e-01 0.188 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.509779e-01 0.186 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.509779e-01 0.186 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.509779e-01 0.186 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.509779e-01 0.186 0 0
FGFR4 ligand binding and activation R-HSA-190322 6.509779e-01 0.186 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.509779e-01 0.186 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.509779e-01 0.186 0 0
FGFR3 mutant receptor activation R-HSA-2033514 6.509779e-01 0.186 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.509779e-01 0.186 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.509779e-01 0.186 0 0
Developmental Cell Lineages R-HSA-9734767 6.522167e-01 0.186 0 0
Signaling by SCF-KIT R-HSA-1433557 6.550984e-01 0.184 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.602362e-01 0.180 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.602362e-01 0.180 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.602362e-01 0.180 0 0
Basigin interactions R-HSA-210991 6.602362e-01 0.180 0 0
GPVI-mediated activation cascade R-HSA-114604 6.613493e-01 0.180 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.675458e-01 0.176 0 0
Signaling by Erythropoietin R-HSA-9006335 6.705197e-01 0.174 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.705197e-01 0.174 0 0
Late endosomal microautophagy R-HSA-9615710 6.705197e-01 0.174 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 6.705197e-01 0.174 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.806856e-01 0.167 0 0
Removal of the Flap Intermediate R-HSA-69166 6.813494e-01 0.167 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.813494e-01 0.167 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.813494e-01 0.167 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.813494e-01 0.167 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.813494e-01 0.167 0 0
FGFR3c ligand binding and activation R-HSA-190372 6.813494e-01 0.167 0 0
Prolactin receptor signaling R-HSA-1170546 6.813494e-01 0.167 0 0
HDL assembly R-HSA-8963896 6.813494e-01 0.167 0 0
Zinc transporters R-HSA-435354 6.813494e-01 0.167 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.838979e-01 0.165 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.838979e-01 0.165 0 0
Smooth Muscle Contraction R-HSA-445355 6.838979e-01 0.165 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.848029e-01 0.164 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.848029e-01 0.164 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.894140e-01 0.162 0 0
Interleukin-17 signaling R-HSA-448424 6.894140e-01 0.162 0 0
DAP12 signaling R-HSA-2424491 6.915525e-01 0.160 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 6.915525e-01 0.160 0 0
Signaling by LTK in cancer R-HSA-9842640 6.917419e-01 0.160 0 0
STAT5 Activation R-HSA-9645135 6.917419e-01 0.160 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.917419e-01 0.160 0 0
Uncoating of the HIV Virion R-HSA-162585 6.917419e-01 0.160 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.917419e-01 0.160 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 6.917419e-01 0.160 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.917419e-01 0.160 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.917419e-01 0.160 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.917419e-01 0.160 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.917419e-01 0.160 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 6.917419e-01 0.160 0 0
Abacavir transmembrane transport R-HSA-2161517 6.917419e-01 0.160 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.917419e-01 0.160 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.917419e-01 0.160 0 0
NADPH regeneration R-HSA-389542 6.917419e-01 0.160 0 0
VLDL assembly R-HSA-8866423 6.917419e-01 0.160 0 0
Nef and signal transduction R-HSA-164944 6.917419e-01 0.160 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.917419e-01 0.160 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.996672e-01 0.155 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.018690e-01 0.154 0 0
Interleukin-1 signaling R-HSA-9020702 7.023808e-01 0.153 0 0
GPCR downstream signalling R-HSA-388396 7.036551e-01 0.153 1 0
Regulation of TNFR1 signaling R-HSA-5357905 7.071892e-01 0.150 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.080165e-01 0.150 0 0
FGFR2 alternative splicing R-HSA-6803529 7.080165e-01 0.150 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.080165e-01 0.150 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.080165e-01 0.150 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.080165e-01 0.150 0 0
Viral Infection Pathways R-HSA-9824446 7.081275e-01 0.150 0 0
Erythropoietin activates RAS R-HSA-9027284 7.095224e-01 0.149 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.095224e-01 0.149 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.095224e-01 0.149 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.095224e-01 0.149 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.095224e-01 0.149 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.095224e-01 0.149 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.095224e-01 0.149 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.095224e-01 0.149 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 7.095224e-01 0.149 0 0
Protein methylation R-HSA-8876725 7.095224e-01 0.149 0 0
Budding and maturation of HIV virion R-HSA-162588 7.116113e-01 0.148 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.116113e-01 0.148 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.150298e-01 0.146 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.169190e-01 0.145 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.226685e-01 0.141 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.295359e-01 0.137 0 0
CHL1 interactions R-HSA-447041 7.295359e-01 0.137 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.295359e-01 0.137 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.295359e-01 0.137 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.295359e-01 0.137 0 0
Recycling of eIF2:GDP R-HSA-72731 7.295359e-01 0.137 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.295359e-01 0.137 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.295359e-01 0.137 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.295359e-01 0.137 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.295359e-01 0.137 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.295359e-01 0.137 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.295359e-01 0.137 0 0
LDL remodeling R-HSA-8964041 7.295359e-01 0.137 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.295359e-01 0.137 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.298935e-01 0.137 0 0
Syndecan interactions R-HSA-3000170 7.298935e-01 0.137 0 0
Ca2+ pathway R-HSA-4086398 7.300574e-01 0.137 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.306981e-01 0.136 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.306981e-01 0.136 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.341407e-01 0.134 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.341407e-01 0.134 0 0
Generation of second messenger molecules R-HSA-202433 7.341407e-01 0.134 0 0
Phosphorylation of the APC/C R-HSA-176412 7.355794e-01 0.133 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.355794e-01 0.133 0 0
Atorvastatin ADME R-HSA-9754706 7.355794e-01 0.133 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.355794e-01 0.133 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.355794e-01 0.133 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.355794e-01 0.133 0 0
Activation of SMO R-HSA-5635838 7.355794e-01 0.133 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.355794e-01 0.133 0 0
Cellular response to hypoxia R-HSA-1234174 7.363259e-01 0.133 0 0
G1/S Transition R-HSA-69206 7.374697e-01 0.132 0 0
Metal ion SLC transporters R-HSA-425410 7.387956e-01 0.131 0 0
Autophagy R-HSA-9612973 7.472479e-01 0.127 0 0
Nuclear RNA decay R-HSA-9930044 7.488211e-01 0.126 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.504344e-01 0.125 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.504344e-01 0.125 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.504599e-01 0.125 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.504599e-01 0.125 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.506400e-01 0.125 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.536541e-01 0.123 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.596157e-01 0.119 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.596157e-01 0.119 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.596157e-01 0.119 0 0
Passive transport by Aquaporins R-HSA-432047 7.596157e-01 0.119 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.596157e-01 0.119 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 7.596157e-01 0.119 0 0
Synthesis of PG R-HSA-1483148 7.596157e-01 0.119 0 0
Signaling by FGFR R-HSA-190236 7.612512e-01 0.118 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.626981e-01 0.118 0 0
Minus-strand DNA synthesis R-HSA-164516 7.626981e-01 0.118 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.626981e-01 0.118 0 0
RSK activation R-HSA-444257 7.626981e-01 0.118 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.626981e-01 0.118 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.626981e-01 0.118 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.626981e-01 0.118 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.626981e-01 0.118 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.626981e-01 0.118 0 0
Interleukin-9 signaling R-HSA-8985947 7.626981e-01 0.118 0 0
Regulation by c-FLIP R-HSA-3371378 7.626981e-01 0.118 0 0
Co-stimulation by ICOS R-HSA-9927354 7.626981e-01 0.118 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.626981e-01 0.118 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.626981e-01 0.118 0 0
Dimerization of procaspase-8 R-HSA-69416 7.626981e-01 0.118 0 0
Alpha-defensins R-HSA-1462054 7.626981e-01 0.118 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.626981e-01 0.118 0 0
Interleukin-23 signaling R-HSA-9020933 7.626981e-01 0.118 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.659730e-01 0.116 0 0
HIV Transcription Initiation R-HSA-167161 7.659730e-01 0.116 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.659730e-01 0.116 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.659730e-01 0.116 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.659730e-01 0.116 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.659730e-01 0.116 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.659940e-01 0.116 0 0
Platelet homeostasis R-HSA-418346 7.670566e-01 0.115 0 0
PI3K Cascade R-HSA-109704 7.678860e-01 0.115 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.697496e-01 0.114 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.697496e-01 0.114 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.697496e-01 0.114 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.697496e-01 0.114 0 0
Tight junction interactions R-HSA-420029 7.697496e-01 0.114 0 0
Extension of Telomeres R-HSA-180786 7.708755e-01 0.113 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.718266e-01 0.112 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.744857e-01 0.111 0 0
Leishmania infection R-HSA-9658195 7.793866e-01 0.108 0 0
Parasitic Infection Pathways R-HSA-9824443 7.793866e-01 0.108 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.817350e-01 0.107 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.817350e-01 0.107 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.817350e-01 0.107 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.817350e-01 0.107 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.817350e-01 0.107 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.817350e-01 0.107 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.817350e-01 0.107 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.817350e-01 0.107 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.822352e-01 0.107 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 7.822352e-01 0.107 0 0
Signaling by NOTCH2 R-HSA-1980145 7.822352e-01 0.107 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.826259e-01 0.106 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.827142e-01 0.106 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.878027e-01 0.104 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.878027e-01 0.104 0 0
CASP8 activity is inhibited R-HSA-5218900 7.917959e-01 0.101 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.917959e-01 0.101 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.917959e-01 0.101 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.917959e-01 0.101 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.917959e-01 0.101 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.917959e-01 0.101 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.917959e-01 0.101 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.917959e-01 0.101 0 0
mRNA Editing R-HSA-75072 7.917959e-01 0.101 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.917959e-01 0.101 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.917959e-01 0.101 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.917959e-01 0.101 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.944953e-01 0.100 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.944953e-01 0.100 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.948265e-01 0.100 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.955986e-01 0.099 0 0
PERK regulates gene expression R-HSA-381042 7.975671e-01 0.098 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.020460e-01 0.096 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.020460e-01 0.096 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.020460e-01 0.096 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.020460e-01 0.096 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.020460e-01 0.096 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.020460e-01 0.096 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.046645e-01 0.094 0 0
Cristae formation R-HSA-8949613 8.046645e-01 0.094 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.046645e-01 0.094 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.071775e-01 0.093 0 0
DAP12 interactions R-HSA-2172127 8.081693e-01 0.092 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.084649e-01 0.092 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.084649e-01 0.092 0 0
Hedgehog 'on' state R-HSA-5632684 8.084649e-01 0.092 0 0
FLT3 signaling in disease R-HSA-9682385 8.120151e-01 0.090 0 0
RUNX2 regulates bone development R-HSA-8941326 8.120151e-01 0.090 0 0
Neutrophil degranulation R-HSA-6798695 8.141860e-01 0.089 0 0
Binding and entry of HIV virion R-HSA-173107 8.173273e-01 0.088 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.173273e-01 0.088 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.173273e-01 0.088 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.173273e-01 0.088 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.173273e-01 0.088 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.173273e-01 0.088 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.173273e-01 0.088 0 0
2-LTR circle formation R-HSA-164843 8.173273e-01 0.088 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.173273e-01 0.088 0 0
Pexophagy R-HSA-9664873 8.173273e-01 0.088 0 0
Maturation of spike protein R-HSA-9683686 8.173273e-01 0.088 0 0
Formation of apoptosome R-HSA-111458 8.173273e-01 0.088 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.173273e-01 0.088 0 0
Josephin domain DUBs R-HSA-5689877 8.173273e-01 0.088 0 0
Tandem pore domain potassium channels R-HSA-1296346 8.173273e-01 0.088 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.173273e-01 0.088 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.173273e-01 0.088 0 0
SARS-CoV Infections R-HSA-9679506 8.191737e-01 0.087 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.196801e-01 0.086 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.203835e-01 0.086 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.203835e-01 0.086 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.203835e-01 0.086 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.203835e-01 0.086 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.206594e-01 0.086 0 0
Regulation of signaling by CBL R-HSA-912631 8.206594e-01 0.086 0 0
Translesion Synthesis by POLH R-HSA-110320 8.206594e-01 0.086 0 0
Other interleukin signaling R-HSA-449836 8.206594e-01 0.086 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.208119e-01 0.086 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.208119e-01 0.086 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.208119e-01 0.086 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.208119e-01 0.086 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.244810e-01 0.084 0 0
Insulin receptor signalling cascade R-HSA-74751 8.288121e-01 0.082 0 0
Signaling by NOTCH3 R-HSA-9012852 8.299210e-01 0.081 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.327738e-01 0.079 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.327738e-01 0.079 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.327738e-01 0.079 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.350110e-01 0.078 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.350110e-01 0.078 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.376861e-01 0.077 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.376861e-01 0.077 0 0
Negative regulation of MET activity R-HSA-6807004 8.376861e-01 0.077 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.376861e-01 0.077 0 0
MET promotes cell motility R-HSA-8875878 8.383750e-01 0.077 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.397291e-01 0.076 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.397291e-01 0.076 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.397291e-01 0.076 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.397291e-01 0.076 0 0
Chylomicron assembly R-HSA-8963888 8.397291e-01 0.076 0 0
Synthesis of PI R-HSA-1483226 8.397291e-01 0.076 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.397291e-01 0.076 0 0
Bicarbonate transporters R-HSA-425381 8.397291e-01 0.076 0 0
Transport of RCbl within the body R-HSA-9758890 8.397291e-01 0.076 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.397291e-01 0.076 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.397291e-01 0.076 0 0
LGI-ADAM interactions R-HSA-5682910 8.397291e-01 0.076 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.397291e-01 0.076 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.397291e-01 0.076 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.405838e-01 0.075 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.411046e-01 0.075 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 8.440755e-01 0.074 0 0
Immune System R-HSA-168256 8.446093e-01 0.073 0 0
Interferon Signaling R-HSA-913531 8.462755e-01 0.072 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.474385e-01 0.072 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.485998e-01 0.071 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.485998e-01 0.071 0 0
IRS-mediated signalling R-HSA-112399 8.506990e-01 0.070 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.532352e-01 0.069 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.532352e-01 0.069 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.532352e-01 0.069 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.532352e-01 0.069 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.532352e-01 0.069 0 0
Lagging Strand Synthesis R-HSA-69186 8.532352e-01 0.069 0 0
ERK/MAPK targets R-HSA-198753 8.532352e-01 0.069 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.532352e-01 0.069 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.593849e-01 0.066 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.593849e-01 0.066 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.593849e-01 0.066 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.593849e-01 0.066 0 0
ERKs are inactivated R-HSA-202670 8.593849e-01 0.066 0 0
Sodium/Calcium exchangers R-HSA-425561 8.593849e-01 0.066 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.602829e-01 0.065 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.610145e-01 0.065 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.612035e-01 0.065 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.612035e-01 0.065 0 0
Attenuation phase R-HSA-3371568 8.615624e-01 0.065 0 0
Glycogen metabolism R-HSA-8982491 8.615624e-01 0.065 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.615624e-01 0.065 0 0
Selenoamino acid metabolism R-HSA-2408522 8.643270e-01 0.063 0 0
Ion channel transport R-HSA-983712 8.658768e-01 0.063 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.674131e-01 0.062 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.674131e-01 0.062 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.674131e-01 0.062 0 0
Parasite infection R-HSA-9664407 8.699932e-01 0.060 0 0
Leishmania phagocytosis R-HSA-9664417 8.699932e-01 0.060 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.699932e-01 0.060 0 0
Maturation of spike protein R-HSA-9694548 8.720490e-01 0.059 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.766310e-01 0.057 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.766310e-01 0.057 0 0
Repression of WNT target genes R-HSA-4641265 8.766310e-01 0.057 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.766310e-01 0.057 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.766310e-01 0.057 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.766310e-01 0.057 0 0
MET activates RAS signaling R-HSA-8851805 8.766310e-01 0.057 0 0
Interleukin-15 signaling R-HSA-8983432 8.766310e-01 0.057 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.766310e-01 0.057 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.766310e-01 0.057 0 0
Polymerase switching R-HSA-69091 8.766310e-01 0.057 0 0
Leading Strand Synthesis R-HSA-69109 8.766310e-01 0.057 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.766310e-01 0.057 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.766310e-01 0.057 0 0
Estrogen biosynthesis R-HSA-193144 8.766310e-01 0.057 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.766310e-01 0.057 0 0
Signaling by KIT in disease R-HSA-9669938 8.803220e-01 0.055 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.803220e-01 0.055 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.803220e-01 0.055 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.803220e-01 0.055 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.803220e-01 0.055 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.803220e-01 0.055 0 0
Free fatty acid receptors R-HSA-444209 8.803220e-01 0.055 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.803220e-01 0.055 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.803220e-01 0.055 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.803220e-01 0.055 0 0
Vesicle-mediated transport R-HSA-5653656 8.803383e-01 0.055 0 0
Intra-Golgi traffic R-HSA-6811438 8.818428e-01 0.055 0 0
Translation of Structural Proteins R-HSA-9683701 8.818428e-01 0.055 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.823473e-01 0.054 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.836703e-01 0.054 0 0
Platelet degranulation R-HSA-114608 8.849299e-01 0.053 0 0
Aquaporin-mediated transport R-HSA-445717 8.860224e-01 0.053 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.860224e-01 0.053 0 0
Signaling by MET R-HSA-6806834 8.871076e-01 0.052 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.907800e-01 0.050 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.909778e-01 0.050 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.909778e-01 0.050 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.909778e-01 0.050 0 0
Orc1 removal from chromatin R-HSA-68949 8.914786e-01 0.050 0 0
Acetylcholine binding and downstream events R-HSA-181431 8.917628e-01 0.050 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 8.917628e-01 0.050 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.917628e-01 0.050 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.917628e-01 0.050 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.917628e-01 0.050 0 0
Chylomicron remodeling R-HSA-8963901 8.917628e-01 0.050 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.917628e-01 0.050 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.917628e-01 0.050 0 0
Processing of SMDT1 R-HSA-8949664 8.917628e-01 0.050 0 0
Interleukin-6 signaling R-HSA-1059683 8.917628e-01 0.050 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.917628e-01 0.050 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.920600e-01 0.050 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.936393e-01 0.049 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.936393e-01 0.049 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.936393e-01 0.049 0 0
Nucleotide Excision Repair R-HSA-5696398 8.960039e-01 0.048 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.010431e-01 0.045 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.027199e-01 0.044 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.027199e-01 0.044 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.027199e-01 0.044 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.027199e-01 0.044 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.028340e-01 0.044 0 0
Dual Incision in GG-NER R-HSA-5696400 9.028340e-01 0.044 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.028340e-01 0.044 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.033830e-01 0.044 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.050395e-01 0.043 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.050395e-01 0.043 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.050395e-01 0.043 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.050395e-01 0.043 0 0
Physiological factors R-HSA-5578768 9.050395e-01 0.043 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.050395e-01 0.043 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.050395e-01 0.043 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.050395e-01 0.043 0 0
P2Y receptors R-HSA-417957 9.050395e-01 0.043 0 0
Signaling by FGFR in disease R-HSA-1226099 9.096426e-01 0.041 0 0
Formation of the cornified envelope R-HSA-6809371 9.107150e-01 0.041 0 0
Regulation of Apoptosis R-HSA-169911 9.113042e-01 0.040 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.113042e-01 0.040 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.123897e-01 0.040 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.123897e-01 0.040 0 0
G protein gated Potassium channels R-HSA-1296059 9.123897e-01 0.040 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.123897e-01 0.040 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.147659e-01 0.039 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.147659e-01 0.039 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.155507e-01 0.038 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.155507e-01 0.038 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.155507e-01 0.038 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.166882e-01 0.038 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.166882e-01 0.038 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.166882e-01 0.038 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.166882e-01 0.038 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.166882e-01 0.038 0 0
Translesion synthesis by REV1 R-HSA-110312 9.166882e-01 0.038 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.166882e-01 0.038 0 0
Biotin transport and metabolism R-HSA-196780 9.166882e-01 0.038 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 9.166882e-01 0.038 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.166882e-01 0.038 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.166882e-01 0.038 0 0
DNA Damage Reversal R-HSA-73942 9.166882e-01 0.038 0 0
Signaling by GPCR R-HSA-372790 9.167915e-01 0.038 1 0
G1/S-Specific Transcription R-HSA-69205 9.190978e-01 0.037 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.190978e-01 0.037 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.190978e-01 0.037 0 0
Triglyceride catabolism R-HSA-163560 9.190978e-01 0.037 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.190978e-01 0.037 0 0
HSF1 activation R-HSA-3371511 9.190978e-01 0.037 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.193210e-01 0.037 1 1
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.199104e-01 0.036 0 0
MET activates PTK2 signaling R-HSA-8874081 9.211517e-01 0.036 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.211517e-01 0.036 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.211517e-01 0.036 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.211517e-01 0.036 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.215986e-01 0.035 0 0
Synthesis of PA R-HSA-1483166 9.258996e-01 0.033 0 0
Degradation of DVL R-HSA-4641258 9.262609e-01 0.033 0 0
NCAM1 interactions R-HSA-419037 9.262609e-01 0.033 0 0
Translation of Structural Proteins R-HSA-9694635 9.263717e-01 0.033 0 0
Translesion synthesis by POLI R-HSA-5656121 9.269086e-01 0.033 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.269086e-01 0.033 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.269086e-01 0.033 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.269086e-01 0.033 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.269086e-01 0.033 1 1
Differentiation of T cells R-HSA-9945266 9.269086e-01 0.033 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.269086e-01 0.033 0 0
Fructose catabolism R-HSA-70350 9.269086e-01 0.033 0 0
Attachment and Entry R-HSA-9678110 9.269086e-01 0.033 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.279353e-01 0.032 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.290831e-01 0.032 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.290831e-01 0.032 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.290831e-01 0.032 0 0
Insulin processing R-HSA-264876 9.290831e-01 0.032 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.290831e-01 0.032 0 0
Dual incision in TC-NER R-HSA-6782135 9.314872e-01 0.031 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.328376e-01 0.030 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.328376e-01 0.030 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.358757e-01 0.029 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.358757e-01 0.029 0 0
Translesion synthesis by POLK R-HSA-5655862 9.358757e-01 0.029 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.358757e-01 0.029 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.358757e-01 0.029 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.358757e-01 0.029 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.358757e-01 0.029 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.359621e-01 0.029 0 0
Prednisone ADME R-HSA-9757110 9.362559e-01 0.029 0 0
Pyrimidine salvage R-HSA-73614 9.362559e-01 0.029 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.362559e-01 0.029 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.362559e-01 0.029 0 0
Regulation of beta-cell development R-HSA-186712 9.366954e-01 0.028 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.388695e-01 0.027 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.388695e-01 0.027 0 0
mRNA Capping R-HSA-72086 9.427366e-01 0.026 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.427366e-01 0.026 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.427366e-01 0.026 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.427366e-01 0.026 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.437432e-01 0.025 0 0
Glycogen storage diseases R-HSA-3229121 9.437432e-01 0.025 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.437432e-01 0.025 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.437432e-01 0.025 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.437432e-01 0.025 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.443966e-01 0.025 0 0
Neurotransmitter clearance R-HSA-112311 9.485871e-01 0.023 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.485871e-01 0.023 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.485871e-01 0.023 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.489067e-01 0.023 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.489067e-01 0.023 0 0
The phototransduction cascade R-HSA-2514856 9.489067e-01 0.023 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.494563e-01 0.023 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.494563e-01 0.023 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.494563e-01 0.023 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.501534e-01 0.022 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.506458e-01 0.022 1 1
G beta:gamma signalling through PLC beta R-HSA-418217 9.506458e-01 0.022 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.506458e-01 0.022 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.506458e-01 0.022 0 0
ABC-family proteins mediated transport R-HSA-382556 9.524114e-01 0.021 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.531914e-01 0.021 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.538645e-01 0.021 0 0
Cargo concentration in the ER R-HSA-5694530 9.538645e-01 0.021 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.540840e-01 0.020 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.540840e-01 0.020 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.540840e-01 0.020 0 0
TCR signaling R-HSA-202403 9.561535e-01 0.019 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.567018e-01 0.019 0 0
Methionine salvage pathway R-HSA-1237112 9.567018e-01 0.019 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.567018e-01 0.019 0 0
Ion transport by P-type ATPases R-HSA-936837 9.577649e-01 0.019 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.614077e-01 0.017 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.620150e-01 0.017 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.620150e-01 0.017 0 0
Glycogen synthesis R-HSA-3322077 9.620150e-01 0.017 0 0
Creatine metabolism R-HSA-71288 9.620150e-01 0.017 0 0
Keratan sulfate degradation R-HSA-2022857 9.620150e-01 0.017 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.620150e-01 0.017 0 0
Pregnenolone biosynthesis R-HSA-196108 9.620150e-01 0.017 0 0
Signaling by NODAL R-HSA-1181150 9.620150e-01 0.017 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.621742e-01 0.017 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.621742e-01 0.017 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.629058e-01 0.016 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.641368e-01 0.016 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.641784e-01 0.016 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.644763e-01 0.016 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.656971e-01 0.015 0 0
Surfactant metabolism R-HSA-5683826 9.656971e-01 0.015 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.662062e-01 0.015 0 0
G-protein activation R-HSA-202040 9.666765e-01 0.015 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.666765e-01 0.015 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.666765e-01 0.015 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.666765e-01 0.015 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.666765e-01 0.015 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.672212e-01 0.014 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.689088e-01 0.014 0 0
Neddylation R-HSA-8951664 9.695013e-01 0.013 0 0
eNOS activation R-HSA-203615 9.702310e-01 0.013 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.702310e-01 0.013 0 0
Hyaluronan metabolism R-HSA-2142845 9.702310e-01 0.013 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.704871e-01 0.013 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.707662e-01 0.013 0 0
Glutathione synthesis and recycling R-HSA-174403 9.707662e-01 0.013 0 0
Attachment and Entry R-HSA-9694614 9.707662e-01 0.013 0 0
Ribavirin ADME R-HSA-9755088 9.707662e-01 0.013 0 0
Assembly Of The HIV Virion R-HSA-175474 9.707662e-01 0.013 0 0
ER-Phagosome pathway R-HSA-1236974 9.714403e-01 0.013 0 0
Potential therapeutics for SARS R-HSA-9679191 9.723191e-01 0.012 0 0
Synthesis of DNA R-HSA-69239 9.724727e-01 0.012 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.733493e-01 0.012 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.733493e-01 0.012 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.743541e-01 0.011 0 0
LDL clearance R-HSA-8964038 9.743541e-01 0.011 0 0
Fructose metabolism R-HSA-5652084 9.743541e-01 0.011 0 0
Triglyceride metabolism R-HSA-8979227 9.750532e-01 0.011 0 0
tRNA processing R-HSA-72306 9.752563e-01 0.011 0 0
Peptide hormone metabolism R-HSA-2980736 9.759312e-01 0.011 0 0
Glycosphingolipid transport R-HSA-9845576 9.761508e-01 0.010 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.761508e-01 0.010 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.769213e-01 0.010 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.775019e-01 0.010 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.775019e-01 0.010 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.775019e-01 0.010 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.775019e-01 0.010 0 0
Biosynthesis of maresins R-HSA-9018682 9.775019e-01 0.010 0 0
Interleukin-20 family signaling R-HSA-8854691 9.775019e-01 0.010 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.785510e-01 0.009 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.786663e-01 0.009 0 0
Degradation of AXIN R-HSA-4641257 9.786663e-01 0.009 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.786663e-01 0.009 0 0
Signaling by Insulin receptor R-HSA-74752 9.790294e-01 0.009 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.790294e-01 0.009 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.790672e-01 0.009 1 0
Formation of paraxial mesoderm R-HSA-9793380 9.792583e-01 0.009 0 0
Nucleotide salvage R-HSA-8956321 9.792583e-01 0.009 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.802635e-01 0.009 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.802635e-01 0.009 0 0
Complex III assembly R-HSA-9865881 9.802635e-01 0.009 0 0
Interleukin-6 family signaling R-HSA-6783589 9.802635e-01 0.009 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.809238e-01 0.008 0 0
Purine salvage R-HSA-74217 9.809238e-01 0.008 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.811009e-01 0.008 0 0
Mitochondrial protein import R-HSA-1268020 9.811009e-01 0.008 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.811256e-01 0.008 0 0
SLC transporter disorders R-HSA-5619102 9.822741e-01 0.008 0 0
Hyaluronan degradation R-HSA-2160916 9.826863e-01 0.008 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.826863e-01 0.008 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.829429e-01 0.007 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.829487e-01 0.007 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.829487e-01 0.007 0 0
RSV-host interactions R-HSA-9833110 9.839011e-01 0.007 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.845920e-01 0.007 0 0
Urea cycle R-HSA-70635 9.848118e-01 0.007 0 0
Abacavir ADME R-HSA-2161522 9.848118e-01 0.007 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.860876e-01 0.006 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.860876e-01 0.006 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.866764e-01 0.006 0 0
Triglyceride biosynthesis R-HSA-75109 9.866764e-01 0.006 0 0
Synthesis of PE R-HSA-1483213 9.866764e-01 0.006 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.866764e-01 0.006 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.869763e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.870338e-01 0.006 0 0
ABC transporter disorders R-HSA-5619084 9.873483e-01 0.006 0 0
Cholesterol biosynthesis R-HSA-191273 9.873483e-01 0.006 0 0
Integrin cell surface interactions R-HSA-216083 9.873483e-01 0.006 0 0
Phospholipid metabolism R-HSA-1483257 9.881624e-01 0.005 0 0
Kidney development R-HSA-9830369 9.882124e-01 0.005 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.892884e-01 0.005 0 0
Thyroxine biosynthesis R-HSA-209968 9.897473e-01 0.004 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.901883e-01 0.004 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.903200e-01 0.004 0 0
Mucopolysaccharidoses R-HSA-2206281 9.910062e-01 0.004 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.915234e-01 0.004 0 0
Interferon gamma signaling R-HSA-877300 9.917705e-01 0.004 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.921107e-01 0.003 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.921107e-01 0.003 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.921107e-01 0.003 0 0
Somitogenesis R-HSA-9824272 9.922984e-01 0.003 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.925237e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.928784e-01 0.003 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.930795e-01 0.003 0 0
HS-GAG degradation R-HSA-2024096 9.930795e-01 0.003 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.931333e-01 0.003 0 0
RAB geranylgeranylation R-HSA-8873719 9.932676e-01 0.003 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.932676e-01 0.003 0 0
Synthesis of PC R-HSA-1483191 9.938793e-01 0.003 0 0
Recycling of bile acids and salts R-HSA-159418 9.939294e-01 0.003 0 0
Collagen degradation R-HSA-1442490 9.939396e-01 0.003 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.940107e-01 0.003 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.940189e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.940786e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.940786e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.942296e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.942296e-01 0.003 0 0
Gluconeogenesis R-HSA-70263 9.945458e-01 0.002 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.946750e-01 0.002 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.946750e-01 0.002 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.946750e-01 0.002 0 0
Heme degradation R-HSA-189483 9.946750e-01 0.002 0 0
Disease R-HSA-1643685 9.950619e-01 0.002 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.953291e-01 0.002 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.956134e-01 0.002 0 0
Azathioprine ADME R-HSA-9748787 9.956721e-01 0.002 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.959028e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.959741e-01 0.002 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.968476e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.968476e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.968476e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.972125e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.972349e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.972349e-01 0.001 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.972827e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.973476e-01 0.001 1 0
Pentose phosphate pathway R-HSA-71336 9.975746e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.975746e-01 0.001 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.975746e-01 0.001 0 0
RAS processing R-HSA-9648002 9.975746e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.975825e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.976246e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.977156e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.978726e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.978783e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.979189e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.979189e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.980878e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.981329e-01 0.001 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.981340e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.983633e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.983791e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.984886e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.985078e-01 0.001 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.985645e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.986567e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.986921e-01 0.001 0 0
Defensins R-HSA-1461973 9.987409e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.988063e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.988407e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.988443e-01 0.001 0 0
Proteasome assembly R-HSA-9907900 9.988956e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.988956e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.989263e-01 0.000 0 0
Downstream TCR signaling R-HSA-202424 9.989263e-01 0.000 0 0
PCP/CE pathway R-HSA-4086400 9.990313e-01 0.000 1 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.990314e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.990314e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.991633e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.991633e-01 0.000 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.992549e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.992549e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.992804e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.994144e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.994144e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.994268e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.995021e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.995591e-01 0.000 0 0
Protein localization R-HSA-9609507 9.995659e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.995907e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.995907e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.996369e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.996369e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.996613e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.997143e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.997712e-01 0.000 0 0
Digestion R-HSA-8935690 9.997712e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.997741e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.997753e-01 0.000 0 0
Keratinization R-HSA-6805567 9.997941e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.998457e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.998457e-01 0.000 0 0
Translation R-HSA-72766 9.998502e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.998647e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.998647e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.998647e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.998793e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998911e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.998994e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999066e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999087e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999087e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999137e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999163e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999298e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.999460e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999460e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999474e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999588e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.999636e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999681e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999698e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999720e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999728e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999755e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999776e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999800e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999802e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.999811e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999879e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999879e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999888e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999905e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999914e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999942e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999945e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999949e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999960e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999978e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999984e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999989e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999990e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999993e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999994e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999997e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Disinhibition of SNARE formation R-HSA-114516 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Nervous system development R-HSA-9675108 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.220446e-16 15.654 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.220446e-16 15.654 0 0
M Phase R-HSA-68886 2.220446e-16 15.654 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.440892e-16 15.353 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.776357e-15 14.750 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.547918e-15 14.020 0 0
Cellular response to heat stress R-HSA-3371556 1.110223e-14 13.955 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.915091e-14 13.050 0 0
Cellular Senescence R-HSA-2559583 1.564304e-13 12.806 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.811884e-13 12.742 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.226463e-12 11.911 0 0
Apoptotic execution phase R-HSA-75153 1.873612e-12 11.727 0 0
Peptide chain elongation R-HSA-156902 4.524048e-12 11.344 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 9.187429e-12 11.037 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.281408e-11 10.892 0 0
Post NMDA receptor activation events R-HSA-438064 1.284206e-11 10.891 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.496225e-11 10.825 0 0
Signaling by ROBO receptors R-HSA-376176 1.521394e-11 10.818 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.145984e-11 10.382 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.868572e-11 10.313 0 0
Influenza Infection R-HSA-168255 7.488521e-11 10.126 0 0
Cell Cycle Checkpoints R-HSA-69620 9.403278e-11 10.027 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.569574e-10 9.804 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.569574e-10 9.804 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.714773e-10 9.766 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.867519e-10 9.729 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.968077e-10 9.528 0 0
Mitotic Prometaphase R-HSA-68877 3.470146e-10 9.460 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.784032e-10 9.422 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.165162e-10 9.380 0 0
Cell-Cell communication R-HSA-1500931 4.117232e-10 9.385 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.352007e-10 9.361 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.660680e-10 9.332 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.672425e-10 9.330 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.984660e-10 9.302 0 0
Eukaryotic Translation Termination R-HSA-72764 7.323246e-10 9.135 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.002095e-10 9.097 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.255894e-10 9.034 0 0
DNA methylation R-HSA-5334118 9.794636e-10 9.009 0 0
Translation initiation complex formation R-HSA-72649 9.928492e-10 9.003 0 0
Selenocysteine synthesis R-HSA-2408557 9.774533e-10 9.010 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.154530e-09 8.938 0 0
HSF1 activation R-HSA-3371511 1.381738e-09 8.860 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.490565e-09 8.827 0 0
HSF1-dependent transactivation R-HSA-3371571 1.487260e-09 8.828 0 0
Aggrephagy R-HSA-9646399 1.495185e-09 8.825 0 0
Attenuation phase R-HSA-3371568 1.495185e-09 8.825 0 0
Viral mRNA Translation R-HSA-192823 1.580340e-09 8.801 0 0
Ribosome-associated quality control R-HSA-9948299 1.593840e-09 8.798 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.785465e-09 8.748 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.960557e-09 8.708 0 0
G2/M Checkpoints R-HSA-69481 2.791651e-09 8.554 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.946423e-09 8.531 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.950432e-09 8.530 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.767215e-09 8.424 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.039119e-09 8.394 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.039119e-09 8.394 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.550302e-09 8.342 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.329241e-09 8.273 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.481646e-09 8.261 0 0
HDACs deacetylate histones R-HSA-3214815 5.762936e-09 8.239 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.284929e-09 8.202 0 0
Mitotic Anaphase R-HSA-68882 6.534929e-09 8.185 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.866625e-09 8.163 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.830241e-09 8.166 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.059537e-09 8.151 0 0
Viral Infection Pathways R-HSA-9824446 7.070954e-09 8.151 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.580442e-09 8.120 0 0
Cell junction organization R-HSA-446728 8.577754e-09 8.067 0 0
HCMV Early Events R-HSA-9609690 9.257000e-09 8.034 0 0
Packaging Of Telomere Ends R-HSA-171306 1.149857e-08 7.939 0 0
PKR-mediated signaling R-HSA-9833482 1.122273e-08 7.950 0 0
Separation of Sister Chromatids R-HSA-2467813 1.119602e-08 7.951 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.149857e-08 7.939 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.262549e-08 7.899 0 0
Nucleosome assembly R-HSA-774815 1.433814e-08 7.844 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.433814e-08 7.844 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.608904e-08 7.793 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.869247e-08 7.728 0 0
HATs acetylate histones R-HSA-3214847 1.973872e-08 7.705 0 0
Apoptosis R-HSA-109581 2.059237e-08 7.686 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.290593e-08 7.640 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.290593e-08 7.640 0 0
Recycling pathway of L1 R-HSA-437239 2.834591e-08 7.548 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.055735e-08 7.515 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.128756e-08 7.505 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.195713e-08 7.495 0 0
Mitotic Prophase R-HSA-68875 3.820867e-08 7.418 0 0
Gap junction trafficking R-HSA-190828 4.301921e-08 7.366 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.385697e-08 7.358 0 0
Meiotic synapsis R-HSA-1221632 4.808224e-08 7.318 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.808224e-08 7.318 0 0
Gap junction trafficking and regulation R-HSA-157858 5.429169e-08 7.265 0 0
Metabolism of RNA R-HSA-8953854 5.685413e-08 7.245 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.500338e-08 7.187 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.905999e-08 7.161 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.919434e-08 7.160 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.784314e-08 7.168 0 0
Depurination R-HSA-73927 6.828445e-08 7.166 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.482876e-08 7.126 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.142868e-08 7.039 0 0
Depyrimidination R-HSA-73928 9.142868e-08 7.039 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.444045e-08 7.025 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.914038e-08 7.004 0 0
Selective autophagy R-HSA-9663891 9.889242e-08 7.005 0 0
Meiotic recombination R-HSA-912446 1.009658e-07 6.996 0 0
Meiosis R-HSA-1500620 1.247188e-07 6.904 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.277622e-07 6.894 0 0
Developmental Biology R-HSA-1266738 1.291358e-07 6.889 0 0
Defective pyroptosis R-HSA-9710421 1.274729e-07 6.895 0 0
L1CAM interactions R-HSA-373760 1.382262e-07 6.859 0 0
Interleukin-12 signaling R-HSA-9020591 1.544507e-07 6.811 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.563654e-07 6.806 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.567302e-07 6.805 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.643542e-07 6.784 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.612320e-07 6.793 0 0
G2/M Transition R-HSA-69275 1.650105e-07 6.782 0 0
DNA Double Strand Break Response R-HSA-5693606 1.832355e-07 6.737 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.943316e-07 6.711 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.085974e-07 6.681 0 0
Cleavage of the damaged purine R-HSA-110331 2.085974e-07 6.681 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.194176e-07 6.659 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.307871e-07 6.637 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.899679e-07 6.538 0 0
Signal Transduction R-HSA-162582 2.958893e-07 6.529 1 0
Diseases of programmed cell death R-HSA-9645723 3.032290e-07 6.518 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.100024e-07 6.509 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.105814e-07 6.508 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.288516e-07 6.483 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.930292e-07 6.406 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.731648e-07 6.325 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.918623e-07 6.308 0 0
Adherens junctions interactions R-HSA-418990 5.362082e-07 6.271 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.878063e-07 6.104 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.382491e-07 6.077 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.739642e-07 6.059 0 0
Cellular response to starvation R-HSA-9711097 9.955686e-07 6.002 0 0
Gene Silencing by RNA R-HSA-211000 1.006412e-06 5.997 0 0
Programmed Cell Death R-HSA-5357801 1.078256e-06 5.967 0 0
DNA Replication R-HSA-69306 1.135526e-06 5.945 0 0
Kinesins R-HSA-983189 1.200574e-06 5.921 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.202618e-06 5.920 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.308173e-06 5.883 0 0
Homology Directed Repair R-HSA-5693538 1.401846e-06 5.853 0 0
Gap junction assembly R-HSA-190861 1.340583e-06 5.873 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.425048e-06 5.846 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.798515e-06 5.745 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.858726e-06 5.731 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.957690e-06 5.708 0 0
Interleukin-12 family signaling R-HSA-447115 2.130677e-06 5.671 0 0
HCMV Infection R-HSA-9609646 2.489600e-06 5.604 0 0
Cell-cell junction organization R-HSA-421270 2.777126e-06 5.556 0 0
rRNA processing R-HSA-72312 2.855066e-06 5.544 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.415437e-06 5.467 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.560064e-06 5.449 0 0
Chromatin modifying enzymes R-HSA-3247509 3.574278e-06 5.447 0 0
Signaling by ERBB2 R-HSA-1227986 3.937955e-06 5.405 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.357663e-06 5.361 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.486510e-06 5.348 0 0
Chromatin organization R-HSA-4839726 4.496943e-06 5.347 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.590192e-06 5.338 0 0
Signaling by VEGF R-HSA-194138 5.057633e-06 5.296 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.059310e-06 5.296 0 0
Selenoamino acid metabolism R-HSA-2408522 5.237251e-06 5.281 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.458050e-06 5.263 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.863976e-06 5.232 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.381711e-06 5.195 0 0
RNA Polymerase I Transcription R-HSA-73864 6.880939e-06 5.162 0 0
Regulation of TP53 Activity R-HSA-5633007 6.905616e-06 5.161 0 0
Signaling by PTK6 R-HSA-8848021 7.802112e-06 5.108 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 7.802112e-06 5.108 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.811298e-06 5.107 0 0
Ub-specific processing proteases R-HSA-5689880 8.567447e-06 5.067 0 0
Autophagy R-HSA-9612973 9.105797e-06 5.041 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.905003e-06 5.004 0 0
ESR-mediated signaling R-HSA-8939211 9.958025e-06 5.002 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.000593e-05 5.000 0 0
Base Excision Repair R-HSA-73884 1.039400e-05 4.983 0 0
DNA Repair R-HSA-73894 1.204731e-05 4.919 0 0
Macroautophagy R-HSA-1632852 1.225943e-05 4.912 0 0
Chromosome Maintenance R-HSA-73886 1.384334e-05 4.859 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.628478e-05 4.788 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.909225e-05 4.719 0 0
Metalloprotease DUBs R-HSA-5689901 2.001468e-05 4.699 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.706163e-05 4.568 0 0
Interferon Signaling R-HSA-913531 2.724793e-05 4.565 0 0
Deubiquitination R-HSA-5688426 3.112491e-05 4.507 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.809682e-05 4.551 0 0
Glycolysis R-HSA-70171 3.027987e-05 4.519 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.984348e-05 4.525 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.300215e-05 4.481 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.421722e-05 4.466 0 0
Membrane Trafficking R-HSA-199991 3.466285e-05 4.460 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.895356e-05 4.409 0 0
FLT3 Signaling R-HSA-9607240 3.905759e-05 4.408 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.975555e-05 4.401 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.998318e-05 4.398 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.275439e-05 4.369 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.296502e-05 4.367 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.299660e-05 4.367 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.411378e-05 4.355 0 0
Protein folding R-HSA-391251 4.502299e-05 4.347 0 0
Telomere Maintenance R-HSA-157579 4.679642e-05 4.330 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.775961e-05 4.238 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.762348e-05 4.170 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.802925e-05 4.167 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.802925e-05 4.167 0 0
Semaphorin interactions R-HSA-373755 6.802925e-05 4.167 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.047577e-05 4.152 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.448704e-05 4.073 1 0
Amyloid fiber formation R-HSA-977225 8.793727e-05 4.056 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.884873e-05 4.051 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.175246e-05 4.037 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.679586e-05 4.014 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.781170e-05 4.010 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.910682e-05 4.004 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 9.955451e-05 4.002 0 0
Signaling by ALK in cancer R-HSA-9700206 9.955451e-05 4.002 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.085215e-04 3.964 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.248108e-04 3.904 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.274126e-04 3.895 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.289742e-04 3.889 0 0
Reproduction R-HSA-1474165 1.378128e-04 3.861 0 0
Translation R-HSA-72766 1.582872e-04 3.801 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.628330e-04 3.788 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.704943e-04 3.768 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.733026e-04 3.761 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.833327e-04 3.737 0 0
Glucose metabolism R-HSA-70326 2.178026e-04 3.662 0 0
Long-term potentiation R-HSA-9620244 2.326167e-04 3.633 0 0
mRNA Splicing R-HSA-72172 2.668119e-04 3.574 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.416999e-04 3.617 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.676739e-04 3.572 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.676739e-04 3.572 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.088723e-04 3.510 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.094670e-04 3.509 0 0
RMTs methylate histone arginines R-HSA-3214858 3.101277e-04 3.508 0 0
Co-inhibition by PD-1 R-HSA-389948 3.136491e-04 3.504 0 0
MAPK family signaling cascades R-HSA-5683057 3.378869e-04 3.471 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.433178e-04 3.464 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.667646e-04 3.436 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.898214e-04 3.409 0 0
Hedgehog 'off' state R-HSA-5610787 3.975895e-04 3.401 0 0
HIV Life Cycle R-HSA-162587 4.082212e-04 3.389 0 0
Infectious disease R-HSA-5663205 4.441974e-04 3.352 0 0
MHC class II antigen presentation R-HSA-2132295 4.491670e-04 3.348 0 0
mRNA 3'-end processing R-HSA-72187 5.149634e-04 3.288 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.263532e-04 3.279 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.305636e-04 3.275 0 0
Centrosome maturation R-HSA-380287 5.306623e-04 3.275 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.322228e-04 3.274 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.374457e-04 3.270 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.067750e-04 3.217 0 0
Signaling by WNT R-HSA-195721 6.146720e-04 3.211 1 0
Intracellular signaling by second messengers R-HSA-9006925 6.436743e-04 3.191 1 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.475337e-04 3.189 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.718911e-04 3.173 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.137030e-04 3.146 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.855767e-04 3.105 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.855767e-04 3.105 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.481470e-04 3.126 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.481470e-04 3.126 0 0
Cilium Assembly R-HSA-5617833 7.988173e-04 3.098 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.350213e-04 3.134 0 0
Gene expression (Transcription) R-HSA-74160 8.198740e-04 3.086 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.536021e-04 3.069 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.536021e-04 3.069 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.575977e-04 3.067 1 0
Mitotic Spindle Checkpoint R-HSA-69618 8.744630e-04 3.058 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 9.124595e-04 3.040 0 0
Oncogene Induced Senescence R-HSA-2559585 1.032468e-03 2.986 0 0
RNA Polymerase II Transcription R-HSA-73857 1.034708e-03 2.985 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.039546e-03 2.983 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.082506e-03 2.966 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.091324e-03 2.962 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.178236e-03 2.929 0 0
S Phase R-HSA-69242 1.203019e-03 2.920 0 0
RET signaling R-HSA-8853659 1.269731e-03 2.896 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.299205e-03 2.886 0 0
UCH proteinases R-HSA-5689603 1.448629e-03 2.839 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.537577e-03 2.813 0 0
Formation of annular gap junctions R-HSA-196025 1.584811e-03 2.800 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.601586e-03 2.795 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.610343e-03 2.793 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.610343e-03 2.793 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.659870e-03 2.780 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.659870e-03 2.780 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.672336e-03 2.777 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.834950e-03 2.736 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.303675e-03 2.638 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.303675e-03 2.638 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.303675e-03 2.638 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.303675e-03 2.638 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.163465e-03 2.665 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.038573e-03 2.691 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.268078e-03 2.644 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.927045e-03 2.715 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.020504e-03 2.695 0 0
DNA Damage Bypass R-HSA-73893 2.152321e-03 2.667 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.090718e-03 2.680 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.038573e-03 2.691 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.268078e-03 2.644 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.927045e-03 2.715 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.277041e-03 2.643 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.268078e-03 2.644 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.424290e-03 2.615 0 0
Gap junction degradation R-HSA-190873 2.436389e-03 2.613 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.436389e-03 2.613 0 0
Nuclear import of Rev protein R-HSA-180746 2.485210e-03 2.605 0 0
Hemostasis R-HSA-109582 2.635304e-03 2.579 1 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.673198e-03 2.573 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.696491e-03 2.569 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.696491e-03 2.569 0 0
Response to metal ions R-HSA-5660526 2.696491e-03 2.569 0 0
HCMV Late Events R-HSA-9610379 2.715489e-03 2.566 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.717799e-03 2.566 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.717799e-03 2.566 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.836566e-03 2.547 0 0
Protein ubiquitination R-HSA-8852135 2.865851e-03 2.543 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.865851e-03 2.543 0 0
EPH-Ephrin signaling R-HSA-2682334 2.873475e-03 2.542 0 0
Regulation of CDH1 Function R-HSA-9764561 2.991288e-03 2.524 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.008445e-03 2.522 0 0
HIV Infection R-HSA-162906 3.011107e-03 2.521 0 0
Adaptive Immune System R-HSA-1280218 3.037329e-03 2.518 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.280481e-03 2.484 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.501386e-03 2.456 0 0
Signaling by Hippo R-HSA-2028269 3.558544e-03 2.449 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.592976e-03 2.445 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.592976e-03 2.445 0 0
FLT3 signaling in disease R-HSA-9682385 3.617509e-03 2.442 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.619957e-03 2.441 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.619957e-03 2.441 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.619957e-03 2.441 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.619957e-03 2.441 0 0
SARS-CoV Infections R-HSA-9679506 3.683327e-03 2.434 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.836113e-03 2.416 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.990891e-03 2.399 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.054130e-03 2.392 0 0
Signaling by NOTCH R-HSA-157118 4.445963e-03 2.352 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.466942e-03 2.350 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.619887e-03 2.335 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.619887e-03 2.335 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.733567e-03 2.325 0 0
MTF1 activates gene expression R-HSA-5660489 4.742058e-03 2.324 0 0
SOS-mediated signalling R-HSA-112412 5.501414e-03 2.260 0 0
Signaling by ERBB4 R-HSA-1236394 5.517181e-03 2.258 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.001923e-03 2.301 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.001923e-03 2.301 0 0
Neutrophil degranulation R-HSA-6798695 6.110056e-03 2.214 0 0
Signaling by SCF-KIT R-HSA-1433557 5.300478e-03 2.276 0 0
Signaling by EGFR R-HSA-177929 6.100913e-03 2.215 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.132726e-03 2.290 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.890097e-03 2.311 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.691801e-03 2.245 0 0
Regulation of PTEN localization R-HSA-8948747 5.501414e-03 2.260 0 0
p75NTR signals via NF-kB R-HSA-193639 5.797692e-03 2.237 0 0
Generic Transcription Pathway R-HSA-212436 6.426709e-03 2.192 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.688781e-03 2.175 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.015999e-03 2.154 0 0
DAG and IP3 signaling R-HSA-1489509 7.181536e-03 2.144 1 0
Host Interactions of HIV factors R-HSA-162909 7.221332e-03 2.141 0 0
Negative regulation of MET activity R-HSA-6807004 7.453893e-03 2.128 0 0
Nephrin family interactions R-HSA-373753 7.453893e-03 2.128 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.565285e-03 2.121 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.733556e-03 2.112 0 0
Activation of the pre-replicative complex R-HSA-68962 7.733556e-03 2.112 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.814032e-03 2.107 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.061904e-03 2.094 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 8.105460e-03 2.091 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 8.105460e-03 2.091 0 0
PIP3 activates AKT signaling R-HSA-1257604 8.257381e-03 2.083 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.309092e-03 2.080 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.450436e-03 2.073 0 0
G1/S Transition R-HSA-69206 8.565609e-03 2.067 0 0
Sema4D in semaphorin signaling R-HSA-400685 8.568521e-03 2.067 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.640042e-03 2.063 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.132428e-03 2.039 0 0
Trafficking of AMPA receptors R-HSA-399719 9.239941e-03 2.034 1 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 9.239941e-03 2.034 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 9.239941e-03 2.034 0 0
Signaling by Hedgehog R-HSA-5358351 9.261797e-03 2.033 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.285151e-03 2.032 0 0
Smooth Muscle Contraction R-HSA-445355 9.328308e-03 2.030 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 9.495547e-03 2.022 0 0
p75NTR recruits signalling complexes R-HSA-209543 9.495547e-03 2.022 0 0
Calmodulin induced events R-HSA-111933 9.572468e-03 2.019 1 1
CaM pathway R-HSA-111997 9.572468e-03 2.019 1 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 9.702256e-03 2.013 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.033629e-02 1.986 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.033629e-02 1.986 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.033629e-02 1.986 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.033629e-02 1.986 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.033629e-02 1.986 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.033629e-02 1.986 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.033629e-02 1.986 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.033629e-02 1.986 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.033629e-02 1.986 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.033629e-02 1.986 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.033629e-02 1.986 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.070737e-02 1.970 0 0
Signaling by MET R-HSA-6806834 1.079587e-02 1.967 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.082681e-02 1.965 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.091929e-02 1.962 0 0
Intraflagellar transport R-HSA-5620924 1.095200e-02 1.961 0 0
Vesicle-mediated transport R-HSA-5653656 1.096064e-02 1.960 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.116293e-02 1.952 0 0
MTOR signalling R-HSA-165159 1.116293e-02 1.952 0 0
Ca-dependent events R-HSA-111996 1.116293e-02 1.952 1 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.119160e-02 1.951 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.119160e-02 1.951 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.146003e-02 1.941 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.167577e-02 1.933 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.167577e-02 1.933 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.167577e-02 1.933 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.247485e-02 1.904 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.291436e-02 1.889 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.291436e-02 1.889 1 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.291436e-02 1.889 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.512248e-02 1.820 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.512248e-02 1.820 0 0
Platelet sensitization by LDL R-HSA-432142 1.524559e-02 1.817 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.512248e-02 1.820 0 0
mTORC1-mediated signalling R-HSA-166208 1.392434e-02 1.856 0 0
Pexophagy R-HSA-9664873 1.565272e-02 1.805 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.565272e-02 1.805 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.262546e-02 1.899 0 0
Josephin domain DUBs R-HSA-5689877 1.565272e-02 1.805 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.524559e-02 1.817 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.392434e-02 1.856 0 0
Immune System R-HSA-168256 1.483055e-02 1.829 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.524559e-02 1.817 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.291436e-02 1.889 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.519820e-02 1.818 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.243888e-02 1.905 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.511841e-02 1.820 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.322408e-02 1.879 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.432804e-02 1.844 0 0
Maturation of protein E R-HSA-9694493 1.262546e-02 1.899 0 0
Maturation of protein E R-HSA-9683683 1.262546e-02 1.899 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.605552e-02 1.794 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.605552e-02 1.794 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.605552e-02 1.794 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.620356e-02 1.790 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.663363e-02 1.779 0 0
Syndecan interactions R-HSA-3000170 1.679059e-02 1.775 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.731592e-02 1.762 0 0
Disease R-HSA-1643685 1.732130e-02 1.761 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.748028e-02 1.757 0 0
RAF activation R-HSA-5673000 1.759082e-02 1.755 0 0
Dual Incision in GG-NER R-HSA-5696400 1.759082e-02 1.755 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.759082e-02 1.755 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.857205e-02 1.731 0 0
MET activates PTPN11 R-HSA-8865999 1.862563e-02 1.730 0 0
Translesion Synthesis by POLH R-HSA-110320 1.872926e-02 1.727 0 0
Regulation of signaling by CBL R-HSA-912631 1.872926e-02 1.727 0 0
Rap1 signalling R-HSA-392517 1.872926e-02 1.727 0 0
The NLRP3 inflammasome R-HSA-844456 1.872926e-02 1.727 0 0
Signaling by RAS mutants R-HSA-6802949 1.907309e-02 1.720 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.907309e-02 1.720 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.907309e-02 1.720 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.907309e-02 1.720 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.907309e-02 1.720 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.907309e-02 1.720 0 0
snRNP Assembly R-HSA-191859 1.925913e-02 1.715 0 0
Metabolism of non-coding RNA R-HSA-194441 1.925913e-02 1.715 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.960760e-02 1.708 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.960760e-02 1.708 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.028929e-02 1.693 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.028929e-02 1.693 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.028929e-02 1.693 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.028929e-02 1.693 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.028929e-02 1.693 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.028929e-02 1.693 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.028929e-02 1.693 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.028929e-02 1.693 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.028929e-02 1.693 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.044611e-02 1.689 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.049530e-02 1.688 0 0
Signaling by NTRKs R-HSA-166520 2.064097e-02 1.685 0 0
PECAM1 interactions R-HSA-210990 2.076044e-02 1.683 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.076044e-02 1.683 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.106497e-02 1.676 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.106497e-02 1.676 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.106497e-02 1.676 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.106497e-02 1.676 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.106497e-02 1.676 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.106497e-02 1.676 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.133537e-02 1.671 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.258174e-02 1.646 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.260027e-02 1.646 0 0
MAP2K and MAPK activation R-HSA-5674135 2.260027e-02 1.646 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.273565e-02 1.643 0 0
Transmission across Chemical Synapses R-HSA-112315 2.276649e-02 1.643 1 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.316933e-02 1.635 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.341024e-02 1.631 0 0
MAP kinase activation R-HSA-450294 2.391256e-02 1.621 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.476784e-02 1.606 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.522266e-02 1.598 0 0
G alpha (z) signalling events R-HSA-418597 2.560908e-02 1.592 1 1
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.600498e-02 1.585 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.600498e-02 1.585 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.600498e-02 1.585 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.679060e-02 1.572 0 0
NF-kB is activated and signals survival R-HSA-209560 2.684778e-02 1.571 0 0
Synthesis of DNA R-HSA-69239 2.708317e-02 1.567 0 0
Signaling by Interleukins R-HSA-449147 2.822130e-02 1.549 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.895127e-02 1.538 1 1
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.897685e-02 1.538 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.921900e-02 1.534 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.970884e-02 1.527 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 4.411179e-02 1.355 0 0
Oligomerization of connexins into connexons R-HSA-190704 4.411179e-02 1.355 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.411179e-02 1.355 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 4.411179e-02 1.355 0 0
Transport of connexins along the secretory pathway R-HSA-190827 4.411179e-02 1.355 0 0
TRAF3 deficiency - HSE R-HSA-5602571 4.411179e-02 1.355 0 0
Co-inhibition by BTLA R-HSA-9927353 4.356876e-02 1.361 0 0
IRS activation R-HSA-74713 4.356876e-02 1.361 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.356876e-02 1.361 0 0
Type I hemidesmosome assembly R-HSA-446107 3.499136e-02 1.456 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.499136e-02 1.456 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.499136e-02 1.456 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.556363e-02 1.341 0 0
MET activates RAS signaling R-HSA-8851805 3.396586e-02 1.469 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.215169e-02 1.375 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.089615e-02 1.510 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.734358e-02 1.428 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.734358e-02 1.428 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.734358e-02 1.428 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.734358e-02 1.428 0 0
Ephrin signaling R-HSA-3928664 4.459168e-02 1.351 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.459168e-02 1.351 1 1
PKA activation in glucagon signalling R-HSA-164378 4.459168e-02 1.351 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.244370e-02 1.489 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.328968e-02 1.364 0 0
Late endosomal microautophagy R-HSA-9615710 4.328968e-02 1.364 0 0
Striated Muscle Contraction R-HSA-390522 3.632339e-02 1.440 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.632339e-02 1.440 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.131127e-02 1.384 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.056528e-02 1.515 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.081320e-02 1.389 0 0
Orc1 removal from chromatin R-HSA-68949 3.788227e-02 1.422 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.540958e-02 1.343 0 0
Stabilization of p53 R-HSA-69541 3.457026e-02 1.461 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.380047e-02 1.359 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.215169e-02 1.375 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.765297e-02 1.424 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.499136e-02 1.456 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.540958e-02 1.343 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.396586e-02 1.469 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.396586e-02 1.469 0 0
Regulation of IFNG signaling R-HSA-877312 3.396586e-02 1.469 0 0
DARPP-32 events R-HSA-180024 4.328968e-02 1.364 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.327551e-02 1.478 0 0
PTEN Regulation R-HSA-6807070 4.515789e-02 1.345 0 0
Opioid Signalling R-HSA-111885 3.448617e-02 1.462 1 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.593144e-02 1.445 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.411179e-02 1.355 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.215169e-02 1.375 0 0
G-protein mediated events R-HSA-112040 4.287061e-02 1.368 1 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.914753e-02 1.407 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.499136e-02 1.456 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.280521e-02 1.484 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.244370e-02 1.489 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.261642e-02 1.370 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.147950e-02 1.502 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.556363e-02 1.341 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.556363e-02 1.341 0 0
Unwinding of DNA R-HSA-176974 4.556363e-02 1.341 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.244370e-02 1.489 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.654925e-02 1.437 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.172045e-02 1.499 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.184631e-02 1.378 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.499136e-02 1.456 0 0
Assembly Of The HIV Virion R-HSA-175474 3.244370e-02 1.489 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.459168e-02 1.351 0 0
NrCAM interactions R-HSA-447038 4.356876e-02 1.361 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.380047e-02 1.359 0 0
IRE1alpha activates chaperones R-HSA-381070 3.547321e-02 1.450 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.499136e-02 1.456 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.635307e-02 1.334 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.674150e-02 1.330 0 0
Signalling to ERKs R-HSA-187687 4.674150e-02 1.330 0 0
PLC beta mediated events R-HSA-112043 4.679028e-02 1.330 1 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.898954e-02 1.310 0 0
DAP12 signaling R-HSA-2424491 4.945617e-02 1.306 0 0
Activation of BH3-only proteins R-HSA-114452 4.945617e-02 1.306 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.034763e-02 1.298 0 0
Co-stimulation by CD28 R-HSA-389356 5.034763e-02 1.298 0 0
Gluconeogenesis R-HSA-70263 5.034763e-02 1.298 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.111511e-02 1.291 0 0
tRNA processing in the nucleus R-HSA-6784531 5.123923e-02 1.290 0 0
Regulation of KIT signaling R-HSA-1433559 5.142806e-02 1.289 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.142806e-02 1.289 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.142806e-02 1.289 0 0
Deadenylation of mRNA R-HSA-429947 5.162449e-02 1.287 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.162449e-02 1.287 0 0
Neurodegenerative Diseases R-HSA-8863678 5.162449e-02 1.287 0 0
GPVI-mediated activation cascade R-HSA-114604 5.262590e-02 1.279 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.265976e-02 1.279 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.265976e-02 1.279 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.265976e-02 1.279 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.392925e-02 1.268 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.553512e-02 1.255 0 0
Interleukin-17 signaling R-HSA-448424 5.553512e-02 1.255 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.563552e-02 1.255 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.563552e-02 1.255 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.596961e-02 1.252 0 0
Signaling by FGFR1 R-HSA-5654736 5.604420e-02 1.251 0 0
EGFR downregulation R-HSA-182971 5.616482e-02 1.251 0 0
TCR signaling R-HSA-202403 5.618361e-02 1.250 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.772219e-02 1.239 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.772219e-02 1.239 0 0
Signal attenuation R-HSA-74749 5.772219e-02 1.239 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.772219e-02 1.239 0 0
Signaling by Leptin R-HSA-2586552 5.772219e-02 1.239 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.903103e-02 1.229 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.932211e-02 1.227 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.009274e-02 1.221 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.009274e-02 1.221 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.024564e-02 1.220 0 0
Signaling by FGFR4 R-HSA-5654743 6.056369e-02 1.218 0 0
Glycogen synthesis R-HSA-3322077 6.155960e-02 1.211 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.155960e-02 1.211 0 0
Formation of definitive endoderm R-HSA-9823730 6.155960e-02 1.211 0 0
Erythropoietin activates RAS R-HSA-9027284 6.180374e-02 1.209 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.180374e-02 1.209 0 0
Translesion synthesis by REV1 R-HSA-110312 6.180374e-02 1.209 0 0
p38MAPK events R-HSA-171007 6.180374e-02 1.209 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.180374e-02 1.209 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.728779e-02 1.172 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.768879e-02 1.169 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.768879e-02 1.169 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.803926e-02 1.167 0 0
Signaling by FGFR2 R-HSA-5654738 6.898226e-02 1.161 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.966507e-02 1.157 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.966507e-02 1.157 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.054065e-02 1.152 0 0
Integrin signaling R-HSA-354192 7.124300e-02 1.147 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.129543e-02 1.147 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.129543e-02 1.147 0 0
Signalling to RAS R-HSA-167044 7.129543e-02 1.147 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.143865e-02 1.146 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.143865e-02 1.146 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.298176e-02 1.137 0 0
Regulation of TP53 Expression R-HSA-6804754 7.303786e-02 1.136 0 0
Diseases of cellular response to stress R-HSA-9675132 7.303786e-02 1.136 0 0
Diseases of Cellular Senescence R-HSA-9630747 7.303786e-02 1.136 0 0
Signaling by RAS GAP mutants R-HSA-9753510 7.303786e-02 1.136 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.303786e-02 1.136 0 0
Translesion synthesis by POLI R-HSA-5656121 7.327404e-02 1.135 0 0
Phosphorylation of the APC/C R-HSA-176412 7.327404e-02 1.135 0 0
Negative regulation of FLT3 R-HSA-9706369 7.327404e-02 1.135 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.366263e-02 1.133 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.366263e-02 1.133 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.377891e-02 1.132 0 0
Signaling by FGFR3 R-HSA-5654741 7.377891e-02 1.132 0 0
Platelet degranulation R-HSA-114608 7.532173e-02 1.123 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.672782e-02 1.115 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.672782e-02 1.115 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.672782e-02 1.115 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.672782e-02 1.115 0 0
CREB phosphorylation R-HSA-199920 7.909990e-02 1.102 0 0
Nef and signal transduction R-HSA-164944 7.909990e-02 1.102 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.962198e-02 1.099 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.962198e-02 1.099 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.040815e-02 1.095 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.086813e-02 1.092 0 0
Glycogen metabolism R-HSA-8982491 8.086813e-02 1.092 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.101323e-02 1.091 0 0
Diseases of DNA repair R-HSA-9675135 8.101323e-02 1.091 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.186415e-02 1.087 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.189945e-02 1.087 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.276788e-02 1.082 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.276788e-02 1.082 0 0
Disorders of Developmental Biology R-HSA-9675151 8.582164e-02 1.066 0 0
Translesion synthesis by POLK R-HSA-5655862 8.582164e-02 1.066 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.582164e-02 1.066 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.582164e-02 1.066 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.582164e-02 1.066 0 0
Inflammasomes R-HSA-622312 8.643785e-02 1.063 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.665955e-02 1.062 0 0
Integration of provirus R-HSA-162592 8.665955e-02 1.062 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.665955e-02 1.062 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.856192e-02 1.053 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.856192e-02 1.053 0 0
Mitophagy R-HSA-5205647 8.856192e-02 1.053 0 0
Signaling by NOTCH2 R-HSA-1980145 8.856192e-02 1.053 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.912642e-02 1.050 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.289838e-02 1.032 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.291873e-02 1.032 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.325552e-02 1.030 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.501806e-02 1.022 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.653013e-02 1.015 0 0
NGF-stimulated transcription R-HSA-9031628 9.674326e-02 1.014 0 0
Signaling by Erythropoietin R-HSA-9006335 9.681302e-02 1.014 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.681302e-02 1.014 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.733979e-02 1.012 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.786454e-02 1.009 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.786454e-02 1.009 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 9.805970e-02 1.009 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.941755e-02 1.003 0 0
Glycogen storage diseases R-HSA-3229121 9.941755e-02 1.003 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.003630e-01 0.998 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.003630e-01 0.998 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 1.003630e-01 0.998 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.003630e-01 0.998 0 0
Recycling of eIF2:GDP R-HSA-72731 1.003630e-01 0.998 0 0
Disinhibition of SNARE formation R-HSA-114516 1.003630e-01 0.998 1 1
Cohesin Loading onto Chromatin R-HSA-2470946 1.003630e-01 0.998 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.003630e-01 0.998 0 0
Signaling by FGFR R-HSA-190236 1.024709e-01 0.989 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.028825e-01 0.988 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.028825e-01 0.988 0 0
TNF signaling R-HSA-75893 1.028825e-01 0.988 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.028825e-01 0.988 0 0
Pervasive developmental disorders R-HSA-9005895 1.033102e-01 0.986 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.033102e-01 0.986 0 0
Disorders of Nervous System Development R-HSA-9697154 1.033102e-01 0.986 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.033102e-01 0.986 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.033102e-01 0.986 0 0
Metallothioneins bind metals R-HSA-5661231 1.033102e-01 0.986 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.033102e-01 0.986 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.033102e-01 0.986 0 0
Circadian clock R-HSA-9909396 1.035324e-01 0.985 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.042390e-01 0.982 0 0
Nucleotide Excision Repair R-HSA-5696398 1.043114e-01 0.982 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.044594e-01 0.981 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.044594e-01 0.981 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.045399e-01 0.981 0 0
KIT mutants bind TKIs R-HSA-9669921 1.045399e-01 0.981 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.045399e-01 0.981 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.045399e-01 0.981 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.045399e-01 0.981 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.045399e-01 0.981 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.045399e-01 0.981 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.045399e-01 0.981 0 0
Defective OGG1 Localization R-HSA-9657050 1.045399e-01 0.981 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.045399e-01 0.981 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.045399e-01 0.981 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.045399e-01 0.981 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 1.045399e-01 0.981 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.045399e-01 0.981 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.045399e-01 0.981 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.045399e-01 0.981 0 0
Death Receptor Signaling R-HSA-73887 1.051720e-01 0.978 0 0
Degradation of CDH1 R-HSA-9766229 1.052370e-01 0.978 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.052370e-01 0.978 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.054526e-01 0.977 0 0
Growth hormone receptor signaling R-HSA-982772 1.054526e-01 0.977 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.063634e-01 0.973 0 0
MET interacts with TNS proteins R-HSA-8875513 1.063634e-01 0.973 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.063634e-01 0.973 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.070789e-01 0.970 0 0
Triglyceride catabolism R-HSA-163560 1.081091e-01 0.966 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.981567e-01 0.703 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 1.981567e-01 0.703 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.981567e-01 0.703 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.981567e-01 0.703 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.981567e-01 0.703 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.981567e-01 0.703 0 0
Hereditary fructose intolerance R-HSA-5657560 1.981567e-01 0.703 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.981567e-01 0.703 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.981567e-01 0.703 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.981567e-01 0.703 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.981567e-01 0.703 0 0
Regulation of gap junction activity R-HSA-191650 1.428536e-01 0.845 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.428536e-01 0.845 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.428536e-01 0.845 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.428536e-01 0.845 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.428536e-01 0.845 0 0
Activation of AMPA receptors R-HSA-399710 1.814834e-01 0.741 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.814834e-01 0.741 0 0
MET receptor recycling R-HSA-8875656 1.236260e-01 0.908 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 1.486173e-01 0.828 0 0
ARMS-mediated activation R-HSA-170984 1.486173e-01 0.828 0 0
Lipophagy R-HSA-9613354 1.486173e-01 0.828 0 0
ALK mutants bind TKIs R-HSA-9700645 1.486173e-01 0.828 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.750609e-01 0.757 0 0
Binding and entry of HIV virion R-HSA-173107 1.750609e-01 0.757 0 0
2-LTR circle formation R-HSA-164843 1.750609e-01 0.757 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.750609e-01 0.757 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.750609e-01 0.757 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.405185e-01 0.852 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.405185e-01 0.852 0 0
GAB1 signalosome R-HSA-180292 1.140223e-01 0.943 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.608541e-01 0.794 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.608541e-01 0.794 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.460552e-01 0.835 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.821819e-01 0.739 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.043742e-01 0.690 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.195135e-01 0.923 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.617495e-01 0.791 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.617495e-01 0.791 0 0
Signaling by KIT in disease R-HSA-9669938 2.002190e-01 0.698 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.002190e-01 0.698 0 0
FGFR2 alternative splicing R-HSA-6803529 2.002190e-01 0.698 0 0
HIV elongation arrest and recovery R-HSA-167287 1.775192e-01 0.751 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.775192e-01 0.751 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.196177e-01 0.658 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.535985e-01 0.814 0 0
Dual incision in TC-NER R-HSA-6782135 1.197208e-01 0.922 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.867071e-01 0.729 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.600193e-01 0.796 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.509882e-01 0.821 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.375113e-01 0.862 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.721790e-01 0.764 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.321651e-01 0.879 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.321651e-01 0.879 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.017702e-01 0.695 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.814834e-01 0.741 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.605636e-01 0.794 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.002190e-01 0.698 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.375113e-01 0.862 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.269113e-01 0.896 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.002190e-01 0.698 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.581658e-01 0.801 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.304896e-01 0.884 0 0
Cyclin D associated events in G1 R-HSA-69231 1.269113e-01 0.896 0 0
G1 Phase R-HSA-69236 1.269113e-01 0.896 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.814834e-01 0.741 0 0
Regulation of Apoptosis R-HSA-169911 1.867071e-01 0.729 0 0
Interleukin-2 signaling R-HSA-9020558 2.026840e-01 0.693 0 0
Aquaporin-mediated transport R-HSA-445717 1.476830e-01 0.831 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.633632e-01 0.787 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.414618e-01 0.849 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.875067e-01 0.727 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.486173e-01 0.828 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.446986e-01 0.840 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.535985e-01 0.814 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.375113e-01 0.862 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.375113e-01 0.862 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.375113e-01 0.862 0 0
Developmental Cell Lineages R-HSA-9734767 1.705544e-01 0.768 0 0
Toll-like Receptor Cascades R-HSA-168898 1.816682e-01 0.741 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.867071e-01 0.729 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.662141e-01 0.779 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.212985e-01 0.916 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.821819e-01 0.739 1 1
DNA strand elongation R-HSA-69190 1.318061e-01 0.880 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.298235e-01 0.887 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.792868e-01 0.746 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.814834e-01 0.741 0 0
Protein methylation R-HSA-8876725 1.608541e-01 0.794 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.721790e-01 0.764 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.552682e-01 0.809 0 0
Interleukin-1 signaling R-HSA-9020702 1.825702e-01 0.739 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.446986e-01 0.840 0 0
Inhibition of PKR R-HSA-169131 1.981567e-01 0.703 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.428536e-01 0.845 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.026840e-01 0.693 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.026840e-01 0.693 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.608541e-01 0.794 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.821819e-01 0.739 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.775192e-01 0.751 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.938799e-01 0.712 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.721790e-01 0.764 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.476830e-01 0.831 0 0
PCP/CE pathway R-HSA-4086400 1.626347e-01 0.789 1 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.806049e-01 0.743 0 0
Neuronal System R-HSA-112316 1.499322e-01 0.824 1 0
Cellular response to hypoxia R-HSA-1234174 1.896937e-01 0.722 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.043742e-01 0.690 0 0
Muscle contraction R-HSA-397014 1.647525e-01 0.783 0 0
Suppression of apoptosis R-HSA-9635465 2.026840e-01 0.693 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.608541e-01 0.794 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.466172e-01 0.834 0 0
RAS processing R-HSA-9648002 1.414618e-01 0.849 0 0
Adrenoceptors R-HSA-390696 1.236260e-01 0.908 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.494517e-01 0.825 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.196177e-01 0.658 0 0
Signaling by NOTCH4 R-HSA-9013694 1.276313e-01 0.894 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.269113e-01 0.896 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.405185e-01 0.852 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.171718e-01 0.663 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.633632e-01 0.787 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.552682e-01 0.809 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.495261e-01 0.825 0 0
Signaling by NOTCH3 R-HSA-9012852 1.646785e-01 0.783 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.814422e-01 0.741 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.314831e-01 0.881 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.617495e-01 0.791 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.167638e-01 0.933 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.043742e-01 0.690 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.026840e-01 0.693 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.814422e-01 0.741 0 0
Regulation of BACH1 activity R-HSA-9708530 1.821819e-01 0.739 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.759139e-01 0.755 0 0
Interleukin-37 signaling R-HSA-9008059 2.107825e-01 0.676 0 0
DAP12 interactions R-HSA-2172127 2.210008e-01 0.656 0 0
Netrin-1 signaling R-HSA-373752 2.210008e-01 0.656 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.214073e-01 0.655 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.214073e-01 0.655 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.214073e-01 0.655 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.214073e-01 0.655 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.214073e-01 0.655 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.214073e-01 0.655 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.214073e-01 0.655 0 0
Diseases of Base Excision Repair R-HSA-9605308 2.214073e-01 0.655 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.214073e-01 0.655 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.214073e-01 0.655 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.231559e-01 0.651 0 0
Leishmania infection R-HSA-9658195 2.237505e-01 0.650 0 0
Parasitic Infection Pathways R-HSA-9824443 2.237505e-01 0.650 0 0
Signaling by NOTCH1 R-HSA-1980143 2.239724e-01 0.650 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.241654e-01 0.649 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.241654e-01 0.649 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.241654e-01 0.649 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.241654e-01 0.649 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.241654e-01 0.649 0 0
Transcription of the HIV genome R-HSA-167172 2.243636e-01 0.649 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.255573e-01 0.647 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.273016e-01 0.643 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.273016e-01 0.643 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.273016e-01 0.643 0 0
Budding and maturation of HIV virion R-HSA-162588 2.281757e-01 0.642 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.281757e-01 0.642 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.281757e-01 0.642 0 0
Regulation of insulin secretion R-HSA-422356 2.305568e-01 0.637 0 0
Activation of RAC1 R-HSA-428540 2.312232e-01 0.636 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.312232e-01 0.636 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 2.312232e-01 0.636 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.312232e-01 0.636 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.312232e-01 0.636 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 2.330355e-01 0.633 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.330355e-01 0.633 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.368032e-01 0.626 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.395600e-01 0.621 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.395600e-01 0.621 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.460064e-01 0.609 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.471135e-01 0.607 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.492692e-01 0.603 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.492692e-01 0.603 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 2.492692e-01 0.603 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.508347e-01 0.601 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.508347e-01 0.601 0 0
Mismatch Repair R-HSA-5358508 2.508347e-01 0.601 0 0
PKA activation R-HSA-163615 2.508347e-01 0.601 0 0
Tie2 Signaling R-HSA-210993 2.508347e-01 0.601 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.542482e-01 0.595 1 0
Interleukin-1 family signaling R-HSA-446652 2.558403e-01 0.592 0 0
Stimuli-sensing channels R-HSA-2672351 2.582933e-01 0.588 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.604289e-01 0.584 0 0
Repression of WNT target genes R-HSA-4641265 2.604289e-01 0.584 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.604289e-01 0.584 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.604289e-01 0.584 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.604289e-01 0.584 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.604289e-01 0.584 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.604289e-01 0.584 0 0
Interleukin-15 signaling R-HSA-8983432 2.604289e-01 0.584 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.604289e-01 0.584 0 0
Signaling by LTK R-HSA-9842663 2.604289e-01 0.584 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.604289e-01 0.584 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.604289e-01 0.584 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.612792e-01 0.583 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.619331e-01 0.582 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.619331e-01 0.582 0 0
STAT5 Activation R-HSA-9645135 2.619331e-01 0.582 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.619331e-01 0.582 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.619331e-01 0.582 0 0
MET Receptor Activation R-HSA-6806942 2.619331e-01 0.582 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 2.632036e-01 0.580 0 0
G-protein beta:gamma signalling R-HSA-397795 2.642208e-01 0.578 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.642208e-01 0.578 0 0
Nuclear RNA decay R-HSA-9930044 2.642208e-01 0.578 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.642208e-01 0.578 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.642208e-01 0.578 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.642208e-01 0.578 0 0
Cardiogenesis R-HSA-9733709 2.642208e-01 0.578 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.648098e-01 0.577 0 0
Diseases of Immune System R-HSA-5260271 2.658331e-01 0.575 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.658331e-01 0.575 0 0
Interleukin-2 family signaling R-HSA-451927 2.658331e-01 0.575 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.658331e-01 0.575 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.740803e-01 0.562 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.748467e-01 0.561 0 0
Insulin receptor signalling cascade R-HSA-74751 2.768792e-01 0.558 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.793753e-01 0.554 0 0
Myogenesis R-HSA-525793 2.807603e-01 0.552 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.807603e-01 0.552 0 0
GPER1 signaling R-HSA-9634597 2.814018e-01 0.551 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 2.819912e-01 0.550 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 2.819912e-01 0.550 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.819912e-01 0.550 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.819912e-01 0.550 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.819912e-01 0.550 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.819912e-01 0.550 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.819912e-01 0.550 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.819912e-01 0.550 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.819912e-01 0.550 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.819912e-01 0.550 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.819912e-01 0.550 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.819912e-01 0.550 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.819912e-01 0.550 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.819912e-01 0.550 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.819912e-01 0.550 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.819912e-01 0.550 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.819912e-01 0.550 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.819912e-01 0.550 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 2.819912e-01 0.550 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.819912e-01 0.550 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 2.819912e-01 0.550 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.819912e-01 0.550 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.819912e-01 0.550 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.819912e-01 0.550 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.819912e-01 0.550 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.826873e-01 0.549 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.826873e-01 0.549 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.827643e-01 0.549 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.827643e-01 0.549 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.833487e-01 0.548 0 0
Rab regulation of trafficking R-HSA-9007101 2.849320e-01 0.545 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.900680e-01 0.538 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.900680e-01 0.538 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.900680e-01 0.538 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 2.900680e-01 0.538 0 0
IRS-mediated signalling R-HSA-112399 2.940274e-01 0.532 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.986118e-01 0.525 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.992143e-01 0.524 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.992143e-01 0.524 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.992143e-01 0.524 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.992143e-01 0.524 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.992143e-01 0.524 0 0
Protein hydroxylation R-HSA-9629569 2.992143e-01 0.524 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.015822e-01 0.521 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.015822e-01 0.521 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.018612e-01 0.520 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.018612e-01 0.520 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.018612e-01 0.520 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.018612e-01 0.520 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.024989e-01 0.519 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.024989e-01 0.519 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.024989e-01 0.519 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.024989e-01 0.519 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.024989e-01 0.519 0 0
Downstream TCR signaling R-HSA-202424 3.034184e-01 0.518 0 0
Cellular response to chemical stress R-HSA-9711123 3.066999e-01 0.513 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.171035e-01 0.499 0 0
Removal of the Flap Intermediate R-HSA-69166 3.199263e-01 0.495 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.199263e-01 0.495 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.199263e-01 0.495 0 0
Signal regulatory protein family interactions R-HSA-391160 3.199263e-01 0.495 0 0
HDL assembly R-HSA-8963896 3.199263e-01 0.495 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.206204e-01 0.494 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.238191e-01 0.490 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.238191e-01 0.490 0 0
Signaling by TGFB family members R-HSA-9006936 3.266661e-01 0.486 0 0
Regulated Necrosis R-HSA-5218859 3.327952e-01 0.478 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.327952e-01 0.478 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.345845e-01 0.475 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.398255e-01 0.469 0 0
G1/S-Specific Transcription R-HSA-69205 3.398255e-01 0.469 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.426538e-01 0.465 0 0
Activation of RAS in B cells R-HSA-1169092 3.426538e-01 0.465 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.426538e-01 0.465 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.435120e-01 0.464 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.446821e-01 0.463 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.446821e-01 0.463 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.446821e-01 0.463 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.446821e-01 0.463 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.454765e-01 0.462 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 3.485489e-01 0.458 0 0
Mitochondrial calcium ion transport R-HSA-8949215 3.485489e-01 0.458 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.485489e-01 0.458 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.498090e-01 0.456 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.498090e-01 0.456 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.498090e-01 0.456 0 0
DCC mediated attractive signaling R-HSA-418885 3.498090e-01 0.456 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.498090e-01 0.456 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 3.498090e-01 0.456 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 3.498090e-01 0.456 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.521940e-01 0.453 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 3.524612e-01 0.453 0 0
G alpha (12/13) signalling events R-HSA-416482 3.539636e-01 0.451 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.542629e-01 0.451 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.570650e-01 0.447 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 3.570650e-01 0.447 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.570650e-01 0.447 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.570650e-01 0.447 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.570650e-01 0.447 0 0
Potassium transport channels R-HSA-1296067 3.570650e-01 0.447 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.570650e-01 0.447 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.570650e-01 0.447 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.570650e-01 0.447 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.570650e-01 0.447 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.570650e-01 0.447 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.570650e-01 0.447 0 0
Signalling to ERK5 R-HSA-198765 3.570650e-01 0.447 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.570650e-01 0.447 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.570650e-01 0.447 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.572781e-01 0.447 0 0
Degradation of DVL R-HSA-4641258 3.591453e-01 0.445 0 0
Degradation of AXIN R-HSA-4641257 3.591453e-01 0.445 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.591453e-01 0.445 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.618324e-01 0.441 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.618324e-01 0.441 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.649489e-01 0.438 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.662562e-01 0.436 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.662562e-01 0.436 0 0
Sensory processing of sound R-HSA-9659379 3.676682e-01 0.435 0 0
NCAM signaling for neurite out-growth R-HSA-375165 3.696004e-01 0.432 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.698928e-01 0.432 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 3.698928e-01 0.432 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 3.698928e-01 0.432 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.698928e-01 0.432 0 0
Pyruvate metabolism R-HSA-70268 3.729293e-01 0.428 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.732982e-01 0.428 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.732982e-01 0.428 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 3.732982e-01 0.428 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 3.754718e-01 0.425 0 0
Leishmania phagocytosis R-HSA-9664417 3.754718e-01 0.425 0 0
Parasite infection R-HSA-9664407 3.754718e-01 0.425 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.774999e-01 0.423 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.795414e-01 0.421 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.795414e-01 0.421 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 3.795414e-01 0.421 0 0
Prolonged ERK activation events R-HSA-169893 3.795414e-01 0.421 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.795414e-01 0.421 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 3.820404e-01 0.418 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.820404e-01 0.418 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.820404e-01 0.418 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.820404e-01 0.418 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.820404e-01 0.418 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.820404e-01 0.418 0 0
MAPK1 (ERK2) activation R-HSA-112411 3.820404e-01 0.418 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.820404e-01 0.418 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.820404e-01 0.418 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.820404e-01 0.418 0 0
Signaling by TGFBR3 R-HSA-9839373 3.876425e-01 0.412 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 3.876425e-01 0.412 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 3.876425e-01 0.412 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.876425e-01 0.412 0 0
Downstream signal transduction R-HSA-186763 3.878470e-01 0.411 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.979686e-01 0.400 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.979686e-01 0.400 0 0
Potential therapeutics for SARS R-HSA-9679191 3.982079e-01 0.400 0 0
ER-Phagosome pathway R-HSA-1236974 3.992607e-01 0.399 0 0
IGF1R signaling cascade R-HSA-2428924 4.004331e-01 0.397 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.089685e-01 0.388 0 0
Passive transport by Aquaporins R-HSA-432047 4.089685e-01 0.388 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.089685e-01 0.388 0 0
NRAGE signals death through JNK R-HSA-193648 4.112148e-01 0.386 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.158792e-01 0.381 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.172941e-01 0.380 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.172941e-01 0.380 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.172941e-01 0.380 0 0
Generation of second messenger molecules R-HSA-202433 4.172941e-01 0.380 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.203806e-01 0.376 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.203806e-01 0.376 0 0
Regulation of CDH11 function R-HSA-9762292 4.203806e-01 0.376 0 0
PI3K/AKT activation R-HSA-198203 4.203806e-01 0.376 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.203806e-01 0.376 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.203806e-01 0.376 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.222328e-01 0.374 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.224696e-01 0.374 0 0
Axonal growth stimulation R-HSA-209563 4.242932e-01 0.372 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.242932e-01 0.372 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.242932e-01 0.372 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.242932e-01 0.372 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.242932e-01 0.372 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 4.242932e-01 0.372 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 4.242932e-01 0.372 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.242932e-01 0.372 0 0
MET activates STAT3 R-HSA-8875791 4.242932e-01 0.372 0 0
Intracellular oxygen transport R-HSA-8981607 4.242932e-01 0.372 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.242932e-01 0.372 0 0
Histamine receptors R-HSA-390650 4.242932e-01 0.372 0 0
Platelet homeostasis R-HSA-418346 4.301413e-01 0.366 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.308228e-01 0.366 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 4.342946e-01 0.362 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.365839e-01 0.360 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.379549e-01 0.359 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.379549e-01 0.359 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.379549e-01 0.359 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.408307e-01 0.356 0 0
HDMs demethylate histones R-HSA-3214842 4.467182e-01 0.350 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.467182e-01 0.350 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.467182e-01 0.350 0 0
TGFBR3 expression R-HSA-9839394 4.467182e-01 0.350 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 4.467182e-01 0.350 0 0
Interleukin-7 signaling R-HSA-1266695 4.467182e-01 0.350 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.467182e-01 0.350 0 0
Antigen processing-Cross presentation R-HSA-1236975 4.544884e-01 0.342 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.557545e-01 0.341 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.557545e-01 0.341 0 0
Translation of Structural Proteins R-HSA-9683701 4.557545e-01 0.341 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.574628e-01 0.340 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.574628e-01 0.340 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.574628e-01 0.340 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.574628e-01 0.340 0 0
Signaling by APC mutants R-HSA-4839744 4.574628e-01 0.340 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.574628e-01 0.340 0 0
Azathioprine ADME R-HSA-9748787 4.584247e-01 0.339 0 0
Peroxisomal protein import R-HSA-9033241 4.604580e-01 0.337 0 0
Triglyceride metabolism R-HSA-8979227 4.604580e-01 0.337 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.643954e-01 0.333 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.660066e-01 0.332 0 0
Polo-like kinase mediated events R-HSA-156711 4.663834e-01 0.331 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.663834e-01 0.331 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.706397e-01 0.327 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.706397e-01 0.327 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.706397e-01 0.327 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.706397e-01 0.327 0 0
eNOS activation R-HSA-203615 4.731372e-01 0.325 0 0
Calnexin/calreticulin cycle R-HSA-901042 4.731372e-01 0.325 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.758974e-01 0.322 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.758974e-01 0.322 0 0
Mitochondrial biogenesis R-HSA-1592230 4.788453e-01 0.320 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.844952e-01 0.315 0 0
HCN channels R-HSA-1296061 4.844952e-01 0.315 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.844952e-01 0.315 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.844952e-01 0.315 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.844952e-01 0.315 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.844952e-01 0.315 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.844952e-01 0.315 0 0
Dopamine receptors R-HSA-390651 4.844952e-01 0.315 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.844952e-01 0.315 0 0
NADE modulates death signalling R-HSA-205025 4.844952e-01 0.315 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.844952e-01 0.315 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.931308e-01 0.307 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.931308e-01 0.307 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.931308e-01 0.307 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.931308e-01 0.307 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.931308e-01 0.307 0 0
Signaling by AXIN mutants R-HSA-4839735 4.931308e-01 0.307 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.931308e-01 0.307 0 0
Neurexins and neuroligins R-HSA-6794361 4.932190e-01 0.307 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.932190e-01 0.307 0 0
TBC/RABGAPs R-HSA-8854214 4.935816e-01 0.307 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.939168e-01 0.306 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.939168e-01 0.306 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.941546e-01 0.306 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.941546e-01 0.306 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.941546e-01 0.306 0 0
Maturation of nucleoprotein R-HSA-9694631 4.941546e-01 0.306 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.941671e-01 0.306 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.941671e-01 0.306 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.941671e-01 0.306 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.941671e-01 0.306 0 0
Maturation of hRSV A proteins R-HSA-9828806 4.941671e-01 0.306 0 0
Inositol phosphate metabolism R-HSA-1483249 5.028009e-01 0.299 0 0
Hedgehog 'on' state R-HSA-5632684 5.075345e-01 0.295 0 0
Heme signaling R-HSA-9707616 5.088436e-01 0.293 0 0
Amine ligand-binding receptors R-HSA-375280 5.121662e-01 0.291 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.143842e-01 0.289 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 5.172408e-01 0.286 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.172408e-01 0.286 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 5.211853e-01 0.283 0 0
Signal transduction by L1 R-HSA-445144 5.211853e-01 0.283 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.211853e-01 0.283 0 0
Integration of energy metabolism R-HSA-163685 5.223774e-01 0.282 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 5.272751e-01 0.278 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 5.272751e-01 0.278 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.272751e-01 0.278 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.272751e-01 0.278 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.272751e-01 0.278 0 0
Polymerase switching R-HSA-69091 5.272751e-01 0.278 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.272751e-01 0.278 0 0
Leading Strand Synthesis R-HSA-69109 5.272751e-01 0.278 0 0
OAS antiviral response R-HSA-8983711 5.272751e-01 0.278 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.384050e-01 0.269 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.384050e-01 0.269 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.384050e-01 0.269 0 0
PTK6 Down-Regulation R-HSA-8849472 5.384050e-01 0.269 0 0
Activation of AKT2 R-HSA-165158 5.384050e-01 0.269 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.384050e-01 0.269 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.384050e-01 0.269 0 0
Reelin signalling pathway R-HSA-8866376 5.384050e-01 0.269 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.384050e-01 0.269 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.384050e-01 0.269 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.384050e-01 0.269 0 0
Inositol transporters R-HSA-429593 5.384050e-01 0.269 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.384050e-01 0.269 0 0
Platelet calcium homeostasis R-HSA-418360 5.398093e-01 0.268 0 0
Glucagon-type ligand receptors R-HSA-420092 5.398093e-01 0.268 0 0
Lagging Strand Synthesis R-HSA-69186 5.474074e-01 0.262 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.474074e-01 0.262 0 0
Basigin interactions R-HSA-210991 5.474074e-01 0.262 0 0
Innate Immune System R-HSA-168249 5.484432e-01 0.261 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.485181e-01 0.261 0 0
Signaling by FGFR in disease R-HSA-1226099 5.517884e-01 0.258 0 0
MET promotes cell motility R-HSA-8875878 5.542261e-01 0.256 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.598243e-01 0.252 0 0
Interleukin-6 signaling R-HSA-1059683 5.598243e-01 0.252 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.598243e-01 0.252 0 0
Maturation of nucleoprotein R-HSA-9683610 5.598243e-01 0.252 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.598243e-01 0.252 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.598243e-01 0.252 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.618276e-01 0.250 0 0
Metabolism of proteins R-HSA-392499 5.708252e-01 0.243 0 0
Signaling by Insulin receptor R-HSA-74752 5.714855e-01 0.243 0 0
Attachment and Entry R-HSA-9694614 5.727667e-01 0.242 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.727667e-01 0.242 0 0
Ribavirin ADME R-HSA-9755088 5.727667e-01 0.242 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.735332e-01 0.241 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.735332e-01 0.241 0 0
Signaling by ALK R-HSA-201556 5.735332e-01 0.241 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.766496e-01 0.239 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 5.832581e-01 0.234 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.832581e-01 0.234 0 0
Plus-strand DNA synthesis R-HSA-164525 5.866800e-01 0.232 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.866800e-01 0.232 0 0
Phosphorylation of Emi1 R-HSA-176417 5.866800e-01 0.232 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.866800e-01 0.232 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.866800e-01 0.232 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.866800e-01 0.232 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.866800e-01 0.232 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.866800e-01 0.232 0 0
PKB-mediated events R-HSA-109703 5.866800e-01 0.232 0 0
PDE3B signalling R-HSA-165160 5.866800e-01 0.232 0 0
Threonine catabolism R-HSA-8849175 5.866800e-01 0.232 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.866800e-01 0.232 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.866800e-01 0.232 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.866800e-01 0.232 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.866800e-01 0.232 0 0
Signaling by MST1 R-HSA-8852405 5.866800e-01 0.232 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.866800e-01 0.232 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.866800e-01 0.232 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.889781e-01 0.230 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.907385e-01 0.229 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.907385e-01 0.229 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 5.907385e-01 0.229 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 5.907385e-01 0.229 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 5.907385e-01 0.229 0 0
Prolactin receptor signaling R-HSA-1170546 5.907385e-01 0.229 0 0
Malate-aspartate shuttle R-HSA-9856872 5.907385e-01 0.229 0 0
Acyl chain remodeling of CL R-HSA-1482798 5.907385e-01 0.229 0 0
Zinc transporters R-HSA-435354 5.907385e-01 0.229 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.907385e-01 0.229 0 0
HIV Transcription Elongation R-HSA-167169 5.923927e-01 0.227 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.923927e-01 0.227 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.923927e-01 0.227 0 0
Translation of Structural Proteins R-HSA-9694635 5.943722e-01 0.226 0 0
Notch-HLH transcription pathway R-HSA-350054 5.972216e-01 0.224 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.972216e-01 0.224 0 0
Signaling by WNT in cancer R-HSA-4791275 6.040692e-01 0.219 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.067588e-01 0.217 0 0
Extension of Telomeres R-HSA-180786 6.081314e-01 0.216 0 0
FCERI mediated MAPK activation R-HSA-2871796 6.111880e-01 0.214 0 0
PI3K Cascade R-HSA-109704 6.172307e-01 0.210 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.200039e-01 0.208 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.200039e-01 0.208 0 0
RAB geranylgeranylation R-HSA-8873719 6.233966e-01 0.205 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.242358e-01 0.205 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.242358e-01 0.205 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.286776e-01 0.202 0 0
HIV Transcription Initiation R-HSA-167161 6.286776e-01 0.202 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.286776e-01 0.202 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.299087e-01 0.201 0 0
Signaling by LTK in cancer R-HSA-9842640 6.299087e-01 0.201 0 0
Uncoating of the HIV Virion R-HSA-162585 6.299087e-01 0.201 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.299087e-01 0.201 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.299087e-01 0.201 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.299087e-01 0.201 0 0
Lactose synthesis R-HSA-5653890 6.299087e-01 0.201 0 0
Abacavir transmembrane transport R-HSA-2161517 6.299087e-01 0.201 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.299087e-01 0.201 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.299087e-01 0.201 0 0
HDL clearance R-HSA-8964011 6.299087e-01 0.201 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.299087e-01 0.201 0 0
Neurofascin interactions R-HSA-447043 6.299087e-01 0.201 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.383265e-01 0.195 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.433075e-01 0.192 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.433075e-01 0.192 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.476269e-01 0.189 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.476269e-01 0.189 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.476269e-01 0.189 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.476269e-01 0.189 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.629338e-01 0.179 0 0
Tight junction interactions R-HSA-420029 6.649072e-01 0.177 0 0
Formation of the nephric duct R-HSA-9830364 6.649072e-01 0.177 0 0
Interferon alpha/beta signaling R-HSA-909733 6.659308e-01 0.177 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.671368e-01 0.176 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.686185e-01 0.175 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.686185e-01 0.175 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.686185e-01 0.175 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.686185e-01 0.175 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.686185e-01 0.175 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.686185e-01 0.175 0 0
VLDL clearance R-HSA-8964046 6.686185e-01 0.175 0 0
Netrin mediated repulsion signals R-HSA-418886 6.686185e-01 0.175 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.686185e-01 0.175 0 0
CHL1 interactions R-HSA-447041 6.686185e-01 0.175 0 0
Ca2+ pathway R-HSA-4086398 6.700319e-01 0.174 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.736311e-01 0.172 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 6.736311e-01 0.172 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 6.736311e-01 0.172 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.736311e-01 0.172 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.736311e-01 0.172 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 6.736311e-01 0.172 0 0
Galactose catabolism R-HSA-70370 6.736311e-01 0.172 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.736311e-01 0.172 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 6.736311e-01 0.172 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.880012e-01 0.162 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.950671e-01 0.158 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 6.980529e-01 0.156 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 6.980529e-01 0.156 0 0
Specification of primordial germ cells R-HSA-9827857 6.980529e-01 0.156 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.980529e-01 0.156 0 0
Protein localization R-HSA-9609507 6.998861e-01 0.155 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.032815e-01 0.153 0 0
Minus-strand DNA synthesis R-HSA-164516 7.032815e-01 0.153 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.032815e-01 0.153 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.032815e-01 0.153 0 0
phospho-PLA2 pathway R-HSA-111995 7.032815e-01 0.153 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.032815e-01 0.153 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.032815e-01 0.153 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.032815e-01 0.153 0 0
Interleukin-9 signaling R-HSA-8985947 7.032815e-01 0.153 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.032815e-01 0.153 0 0
Fructose biosynthesis R-HSA-5652227 7.032815e-01 0.153 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.032815e-01 0.153 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.032815e-01 0.153 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.032815e-01 0.153 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.032815e-01 0.153 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.032815e-01 0.153 0 0
Nucleotide salvage defects R-HSA-9734207 7.032815e-01 0.153 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.032815e-01 0.153 0 0
Sodium/Proton exchangers R-HSA-425986 7.032815e-01 0.153 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.052029e-01 0.152 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.055621e-01 0.151 0 0
Ion homeostasis R-HSA-5578775 7.082208e-01 0.150 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.103214e-01 0.149 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.202561e-01 0.143 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.209386e-01 0.142 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.209386e-01 0.142 0 0
Apoptotic factor-mediated response R-HSA-111471 7.209386e-01 0.142 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.239120e-01 0.140 0 0
Pyroptosis R-HSA-5620971 7.239120e-01 0.140 0 0
Elastic fibre formation R-HSA-1566948 7.309357e-01 0.136 0 0
RSV-host interactions R-HSA-9833110 7.323811e-01 0.135 0 0
Interleukin-21 signaling R-HSA-9020958 7.343205e-01 0.134 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.343205e-01 0.134 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.343205e-01 0.134 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.343205e-01 0.134 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.343205e-01 0.134 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.343205e-01 0.134 0 0
Calcineurin activates NFAT R-HSA-2025928 7.343205e-01 0.134 0 0
WNT mediated activation of DVL R-HSA-201688 7.343205e-01 0.134 0 0
Interleukin-1 processing R-HSA-448706 7.343205e-01 0.134 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.343205e-01 0.134 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.343205e-01 0.134 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.343205e-01 0.134 0 0
Metal ion SLC transporters R-HSA-425410 7.391946e-01 0.131 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.416799e-01 0.130 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.423424e-01 0.129 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.423424e-01 0.129 0 0
Specification of the neural plate border R-HSA-9834899 7.423424e-01 0.129 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.423424e-01 0.129 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 7.571592e-01 0.121 0 0
Ion channel transport R-HSA-983712 7.617827e-01 0.118 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.621142e-01 0.118 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.621142e-01 0.118 0 0
Interleukin-27 signaling R-HSA-9020956 7.621142e-01 0.118 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.621142e-01 0.118 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.621142e-01 0.118 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.623238e-01 0.118 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.623238e-01 0.118 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.623238e-01 0.118 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.658999e-01 0.116 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.712764e-01 0.113 0 0
Aspartate and asparagine metabolism R-HSA-8963693 7.744708e-01 0.111 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 7.750009e-01 0.111 0 0
The phototransduction cascade R-HSA-2514856 7.784513e-01 0.109 0 0
Post-translational protein modification R-HSA-597592 7.797760e-01 0.108 0 0
ABC-family proteins mediated transport R-HSA-382556 7.801770e-01 0.108 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.809461e-01 0.107 0 0
G-protein activation R-HSA-202040 7.809461e-01 0.107 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.809461e-01 0.107 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.809461e-01 0.107 0 0
Mitochondrial protein import R-HSA-1268020 7.832605e-01 0.106 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.848114e-01 0.105 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.848114e-01 0.105 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.870017e-01 0.104 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.870017e-01 0.104 0 0
vRNA Synthesis R-HSA-192814 7.870017e-01 0.104 0 0
vRNP Assembly R-HSA-192905 7.870017e-01 0.104 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.870017e-01 0.104 0 0
Propionyl-CoA catabolism R-HSA-71032 7.870017e-01 0.104 0 0
Bicarbonate transporters R-HSA-425381 7.870017e-01 0.104 0 0
LGI-ADAM interactions R-HSA-5682910 7.870017e-01 0.104 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.870017e-01 0.104 0 0
Transport of RCbl within the body R-HSA-9758890 7.870017e-01 0.104 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 7.871243e-01 0.104 0 0
Leishmania parasite growth and survival R-HSA-9664433 7.871243e-01 0.104 0 0
Intra-Golgi traffic R-HSA-6811438 7.883599e-01 0.103 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.913258e-01 0.102 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.982750e-01 0.098 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.982750e-01 0.098 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.010766e-01 0.096 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.010766e-01 0.096 0 0
Iron uptake and transport R-HSA-917937 8.084890e-01 0.092 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.092869e-01 0.092 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.092869e-01 0.092 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.092869e-01 0.092 0 0
Plasmalogen biosynthesis R-HSA-75896 8.092869e-01 0.092 0 0
ERKs are inactivated R-HSA-202670 8.092869e-01 0.092 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.092869e-01 0.092 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.092869e-01 0.092 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.092869e-01 0.092 0 0
Sodium/Calcium exchangers R-HSA-425561 8.092869e-01 0.092 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.143771e-01 0.089 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.143771e-01 0.089 0 0
Fructose metabolism R-HSA-5652084 8.143771e-01 0.089 0 0
LDL clearance R-HSA-8964038 8.143771e-01 0.089 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.171717e-01 0.088 0 0
Heme degradation R-HSA-189483 8.171717e-01 0.088 0 0
Adipogenesis R-HSA-9843745 8.229171e-01 0.085 0 0
Paracetamol ADME R-HSA-9753281 8.235036e-01 0.084 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 8.292416e-01 0.081 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 8.292416e-01 0.081 0 0
Interleukin-35 Signalling R-HSA-8984722 8.292416e-01 0.081 0 0
Acetylation R-HSA-156582 8.292416e-01 0.081 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.292416e-01 0.081 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.292416e-01 0.081 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.292416e-01 0.081 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.293194e-01 0.081 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.293194e-01 0.081 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.293194e-01 0.081 0 0
Interleukin-20 family signaling R-HSA-8854691 8.293194e-01 0.081 0 0
Signal amplification R-HSA-392518 8.297910e-01 0.081 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.335307e-01 0.079 0 0
ABC transporter disorders R-HSA-5619084 8.354318e-01 0.078 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 8.409505e-01 0.075 0 0
Neddylation R-HSA-8951664 8.412118e-01 0.075 0 0
PERK regulates gene expression R-HSA-381042 8.416549e-01 0.075 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.418969e-01 0.075 0 0
Interleukin-6 family signaling R-HSA-6783589 8.431683e-01 0.074 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.431683e-01 0.074 0 0
Complex III assembly R-HSA-9865881 8.431683e-01 0.074 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.471095e-01 0.072 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.471095e-01 0.072 0 0
Processing of SMDT1 R-HSA-8949664 8.471095e-01 0.072 0 0
Frs2-mediated activation R-HSA-170968 8.471095e-01 0.072 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.471095e-01 0.072 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.471095e-01 0.072 0 0
Formation of axial mesoderm R-HSA-9796292 8.471095e-01 0.072 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.471095e-01 0.072 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.471095e-01 0.072 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.471095e-01 0.072 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.471095e-01 0.072 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.481483e-01 0.072 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 8.512571e-01 0.070 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.521874e-01 0.069 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.527958e-01 0.069 0 0
RNA Polymerase III Transcription R-HSA-74158 8.527958e-01 0.069 0 0
FOXO-mediated transcription R-HSA-9614085 8.551659e-01 0.068 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.556254e-01 0.068 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.559890e-01 0.068 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.559890e-01 0.068 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.559890e-01 0.068 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.559890e-01 0.068 0 0
Regulation of beta-cell development R-HSA-186712 8.608439e-01 0.065 0 0
Hydrolysis of LPC R-HSA-1483115 8.631086e-01 0.064 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.631086e-01 0.064 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.631086e-01 0.064 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.631086e-01 0.064 0 0
Ciprofloxacin ADME R-HSA-9793528 8.631086e-01 0.064 0 0
Voltage gated Potassium channels R-HSA-1296072 8.632460e-01 0.064 0 0
ECM proteoglycans R-HSA-3000178 8.670313e-01 0.062 0 0
TRP channels R-HSA-3295583 8.678449e-01 0.062 0 0
Urea cycle R-HSA-70635 8.678449e-01 0.062 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.678449e-01 0.062 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.730379e-01 0.059 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.744173e-01 0.058 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.774344e-01 0.057 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.774344e-01 0.057 0 0
Protein lipoylation R-HSA-9857492 8.774344e-01 0.057 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.774344e-01 0.057 0 0
Transport and metabolism of PAPS R-HSA-174362 8.774344e-01 0.057 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.774344e-01 0.057 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 8.774344e-01 0.057 0 0
Biotin transport and metabolism R-HSA-196780 8.774344e-01 0.057 0 0
Other semaphorin interactions R-HSA-416700 8.774344e-01 0.057 0 0
Cristae formation R-HSA-8949613 8.787975e-01 0.056 0 0
Insulin processing R-HSA-264876 8.787975e-01 0.056 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.814566e-01 0.055 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.822036e-01 0.054 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.822036e-01 0.054 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.842956e-01 0.053 0 0
Signaling by PDGF R-HSA-186797 8.842956e-01 0.053 0 0
Telomere Extension By Telomerase R-HSA-171319 8.889060e-01 0.051 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.889060e-01 0.051 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.889060e-01 0.051 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.889060e-01 0.051 0 0
Fructose catabolism R-HSA-70350 8.902617e-01 0.050 0 0
Activation of SMO R-HSA-5635838 8.902617e-01 0.050 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.902617e-01 0.050 0 0
Attachment and Entry R-HSA-9678110 8.902617e-01 0.050 0 0
Virus Assembly and Release R-HSA-168268 8.902617e-01 0.050 0 0
Formation of the cornified envelope R-HSA-6809371 8.936246e-01 0.049 0 0
G alpha (q) signalling events R-HSA-416476 8.950928e-01 0.048 0 0
mRNA Capping R-HSA-72086 8.982270e-01 0.047 0 0
Phase 2 - plateau phase R-HSA-5576893 9.017472e-01 0.045 0 0
Glycine degradation R-HSA-6783984 9.017472e-01 0.045 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.017472e-01 0.045 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.017472e-01 0.045 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.017472e-01 0.045 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.017472e-01 0.045 0 0
Coenzyme A biosynthesis R-HSA-196783 9.017472e-01 0.045 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.028203e-01 0.044 0 0
Nucleotide biosynthesis R-HSA-8956320 9.037753e-01 0.044 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.068147e-01 0.042 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.068147e-01 0.042 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.068147e-01 0.042 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.068147e-01 0.042 0 0
SLC transporter disorders R-HSA-5619102 9.118894e-01 0.040 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.120312e-01 0.040 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.120312e-01 0.040 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.120312e-01 0.040 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.120312e-01 0.040 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.120312e-01 0.040 0 0
Choline catabolism R-HSA-6798163 9.120312e-01 0.040 0 0
Extracellular matrix organization R-HSA-1474244 9.138699e-01 0.039 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.173573e-01 0.037 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.193585e-01 0.037 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.212394e-01 0.036 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 9.212394e-01 0.036 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.212394e-01 0.036 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.212394e-01 0.036 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.219925e-01 0.035 0 0
G0 and Early G1 R-HSA-1538133 9.219925e-01 0.035 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.219925e-01 0.035 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.219925e-01 0.035 0 0
HS-GAG degradation R-HSA-2024096 9.219925e-01 0.035 0 0
Proteasome assembly R-HSA-9907900 9.257742e-01 0.033 0 0
Dectin-2 family R-HSA-5621480 9.274008e-01 0.033 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.286774e-01 0.032 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.294841e-01 0.032 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.294841e-01 0.032 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.294841e-01 0.032 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.294841e-01 0.032 0 0
Other interleukin signaling R-HSA-449836 9.294841e-01 0.032 0 0
PI Metabolism R-HSA-1483255 9.300375e-01 0.031 0 0
COPII-mediated vesicle transport R-HSA-204005 9.309266e-01 0.031 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.314022e-01 0.031 0 0
Somitogenesis R-HSA-9824272 9.314022e-01 0.031 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.348180e-01 0.029 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.348180e-01 0.029 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.363718e-01 0.029 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.368663e-01 0.028 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.368663e-01 0.028 0 0
Creatine metabolism R-HSA-71288 9.368663e-01 0.028 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.368663e-01 0.028 0 0
Pregnenolone biosynthesis R-HSA-196108 9.368663e-01 0.028 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.371324e-01 0.028 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.393456e-01 0.027 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.404551e-01 0.027 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.404551e-01 0.027 0 0
Hyaluronan metabolism R-HSA-2142845 9.404551e-01 0.027 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.404551e-01 0.027 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.404551e-01 0.027 0 0
tRNA Aminoacylation R-HSA-379724 9.415397e-01 0.026 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.415397e-01 0.026 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.417988e-01 0.026 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.434760e-01 0.025 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.434760e-01 0.025 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.434760e-01 0.025 0 0
ERK/MAPK targets R-HSA-198753 9.434760e-01 0.025 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.434760e-01 0.025 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.434760e-01 0.025 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.434760e-01 0.025 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.434760e-01 0.025 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.456268e-01 0.024 0 0
Serine metabolism R-HSA-977347 9.493940e-01 0.023 0 0
Glutathione synthesis and recycling R-HSA-174403 9.493940e-01 0.023 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.497606e-01 0.022 0 0
HS-GAG biosynthesis R-HSA-2022928 9.503687e-01 0.022 0 0
RUNX2 regulates bone development R-HSA-8941326 9.503687e-01 0.022 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.546928e-01 0.020 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.546928e-01 0.020 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.546928e-01 0.020 0 0
Cellular hexose transport R-HSA-189200 9.546928e-01 0.020 0 0
NCAM1 interactions R-HSA-419037 9.547140e-01 0.020 0 0
tRNA processing R-HSA-72306 9.550132e-01 0.020 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.564875e-01 0.019 0 0
Ion transport by P-type ATPases R-HSA-936837 9.564875e-01 0.019 0 0
Purine salvage R-HSA-74217 9.586939e-01 0.018 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.586939e-01 0.018 0 0
Biosynthesis of maresins R-HSA-9018682 9.594370e-01 0.018 0 0
Formation of the ureteric bud R-HSA-9830674 9.594370e-01 0.018 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.594370e-01 0.018 0 0
Carnitine shuttle R-HSA-200425 9.594370e-01 0.018 0 0
Integrin cell surface interactions R-HSA-216083 9.599995e-01 0.018 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.610132e-01 0.017 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.612710e-01 0.017 0 0
Pentose phosphate pathway R-HSA-71336 9.623372e-01 0.017 0 0
CYP2E1 reactions R-HSA-211999 9.636847e-01 0.016 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.636847e-01 0.016 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.636847e-01 0.016 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.636847e-01 0.016 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.640981e-01 0.016 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.674878e-01 0.014 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.674878e-01 0.014 0 0
G protein gated Potassium channels R-HSA-1296059 9.674878e-01 0.014 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.674878e-01 0.014 0 0
Hyaluronan degradation R-HSA-2160916 9.674878e-01 0.014 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.674878e-01 0.014 0 0
Laminin interactions R-HSA-3000157 9.674878e-01 0.014 0 0
Maturation of spike protein R-HSA-9694548 9.687193e-01 0.014 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.698224e-01 0.013 0 0
MET activates PTK2 signaling R-HSA-8874081 9.708928e-01 0.013 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.708928e-01 0.013 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.708928e-01 0.013 0 0
Abacavir ADME R-HSA-2161522 9.708928e-01 0.013 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.715061e-01 0.013 0 0
Mitochondrial protein degradation R-HSA-9837999 9.723437e-01 0.012 0 0
Collagen formation R-HSA-1474290 9.723437e-01 0.012 0 0
Interferon gamma signaling R-HSA-877300 9.738635e-01 0.012 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.739414e-01 0.011 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.739414e-01 0.011 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.739414e-01 0.011 0 0
Activation of GABAB receptors R-HSA-991365 9.740526e-01 0.011 0 0
GABA B receptor activation R-HSA-977444 9.740526e-01 0.011 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.763609e-01 0.010 0 0
Insulin receptor recycling R-HSA-77387 9.766709e-01 0.010 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.766709e-01 0.010 0 0
Pyrimidine salvage R-HSA-73614 9.766709e-01 0.010 0 0
Potassium Channels R-HSA-1296071 9.774816e-01 0.010 0 0
Surfactant metabolism R-HSA-5683826 9.785018e-01 0.009 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.785018e-01 0.009 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.790256e-01 0.009 0 0
Thyroxine biosynthesis R-HSA-209968 9.791146e-01 0.009 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.791146e-01 0.009 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.804397e-01 0.009 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.813024e-01 0.008 0 0
Neurotransmitter clearance R-HSA-112311 9.813024e-01 0.008 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.816811e-01 0.008 0 0
Cargo concentration in the ER R-HSA-5694530 9.832612e-01 0.007 0 0
DAG1 glycosylations R-HSA-8931838 9.850149e-01 0.007 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.865849e-01 0.006 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.866297e-01 0.006 0 0
G alpha (s) signalling events R-HSA-418555 9.873462e-01 0.006 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.878502e-01 0.005 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.879906e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.879906e-01 0.005 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.879963e-01 0.005 0 0
Gastrulation R-HSA-9758941 9.882233e-01 0.005 0 0
FCGR activation R-HSA-2029481 9.884618e-01 0.005 0 0
G alpha (i) signalling events R-HSA-418594 9.886565e-01 0.005 1 0
Complex IV assembly R-HSA-9864848 9.889618e-01 0.005 0 0
Kidney development R-HSA-9830369 9.890921e-01 0.005 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.892490e-01 0.005 0 0
RA biosynthesis pathway R-HSA-5365859 9.892490e-01 0.005 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.892490e-01 0.005 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.900052e-01 0.004 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.903756e-01 0.004 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.903756e-01 0.004 0 0
Glycosphingolipid transport R-HSA-9845576 9.913842e-01 0.004 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.913842e-01 0.004 0 0
Cardiac conduction R-HSA-5576891 9.915181e-01 0.004 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.918882e-01 0.004 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.922872e-01 0.003 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.922872e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.922872e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.922872e-01 0.003 0 0
Retinoid metabolism and transport R-HSA-975634 9.923235e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.923235e-01 0.003 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.930956e-01 0.003 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.938193e-01 0.003 0 0
Synthesis of PA R-HSA-1483166 9.938209e-01 0.003 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.944672e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.944672e-01 0.002 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.944672e-01 0.002 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.949154e-01 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.949154e-01 0.002 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.949165e-01 0.002 0 0
GABA receptor activation R-HSA-977443 9.953890e-01 0.002 0 0
Glutathione conjugation R-HSA-156590 9.953890e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.953890e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.953890e-01 0.002 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.955023e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.955664e-01 0.002 0 0
Heme biosynthesis R-HSA-189451 9.955664e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.958191e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.958891e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.960680e-01 0.002 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.962435e-01 0.002 0 0
Complex I biogenesis R-HSA-6799198 9.965645e-01 0.001 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.965645e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.968199e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.968652e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.969397e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.975766e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.976848e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.976848e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.977191e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.977191e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.981724e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.984435e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.984435e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.986443e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.987466e-01 0.001 0 0
Glucuronidation R-HSA-156588 9.989499e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.991517e-01 0.000 1 0
Metabolism of amine-derived hormones R-HSA-209776 9.991587e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.992830e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.992927e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.993009e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.993826e-01 0.000 0 0
Keratinization R-HSA-6805567 9.994349e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.995167e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.995546e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.995777e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.996535e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.997224e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.997456e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997516e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997516e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.997798e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998574e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.998624e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.998723e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.998857e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.998857e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998977e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.998984e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999267e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999326e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999332e-01 0.000 1 0
Degradation of the extracellular matrix R-HSA-1474228 9.999333e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999344e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999475e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999572e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999660e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999704e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999725e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999784e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999805e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999841e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999884e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999897e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999934e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999974e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999981e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999983e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999986e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999988e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999991e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999992e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999993e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways