CAMK2D

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S22	Sugiyama	HNRNPA1L3 HNRNPA1P48	SKSEsPKEPEQLRKLFIGGLsFEtTDESLRSHFEQWGTLTD
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A0A2R8Y4L2	T25	Sugiyama	HNRNPA1L3 HNRNPA1P48	EsPKEPEQLRKLFIGGLsFEtTDESLRSHFEQWGTLTDCVV
A4FU28	S140	Sugiyama	CTAGE9	AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
A5A3E0	Y940	Sugiyama	POTEF A26C1B	ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00273	S28	Sugiyama	DFFA DFF1 DFF45 H13	GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O00488	S93	Sugiyama	ZNF593 ZT86	STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O00488	Y97	Sugiyama	ZNF593 ZT86	KTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVPPRRL
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974	S995	Sugiyama	PPP1R12A MBS MYPT1	ADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLK
O15084	S1011	SIGNOR\|EPSD\|PSP	ANKRD28 KIAA0379	PLssLTFNAINRYTNTsKtVsFEALPIMRNEPSSYCSFNNI
O15212	T38	Sugiyama	PFDN6 HKE2 PFD6	QLQKDLSKSMSGRQKLEAQLtENNIVKEELALLDGsNVVFK
O43164	S253	Sugiyama	PJA2 KIAA0438 RNF131	LDsVPLVKssAGDTEFVHQNsQEIQRSSQDEMVSTKQQNNT
O43399	S161	Sugiyama	TPD52L2	sAALstVGsAIsRKLGDMRNsAtFKsFEDRVGtIKSKVVGD
O43399	S166	Sugiyama	TPD52L2	tVGsAIsRKLGDMRNsAtFKsFEDRVGtIKSKVVGDRENGs
O43399	T163	Sugiyama	TPD52L2	ALstVGsAIsRKLGDMRNsAtFKsFEDRVGtIKSKVVGDRE
O43423	S100	Sugiyama	ANP32CP PP32R1	AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43852	S44	Sugiyama	CALU	KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O43852	T196	Sugiyama	CALU	FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O60220	S94	Sugiyama	TIMM8A DDP DDP1 TIM8A	SQFILNRLEQTQKSKPVFSEsLsD_________________
O60763	S805	Sugiyama	USO1 VDP	EQVAELKQELATLKSQLNSQsVEITKLQTEKQELLQKTEAF
O60841	S107	Sugiyama	EIF5B IF2 KIAA0741	NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60927	S74	Sugiyama	PPP1R11 HCGV TCTE5	GRRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGH
O60927	T75	Sugiyama	PPP1R11 HCGV TCTE5	RRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHR
O94992	S268	Sugiyama	HEXIM1 CLP1 EDG1 HIS1 MAQ1	EDGGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELI
O94992	T270	Sugiyama	HEXIM1 CLP1 EDG1 HIS1 MAQ1	GGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELIKE
O95155	S105	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95218	S120	Sugiyama	ZRANB2 ZIS ZNF265	tGYGGGFNERENVEyIEREEsDGEyDEFGRKKKKYRGKAVG
O95218	S188	Sugiyama	ZRANB2 ZIS ZNF265	KLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRRSRSKSRS
O95425	S968	Sugiyama	SVIL	GETESKRALTGRDSGMEKyGsFEEAEASYPILNRAREGDSH
O95626	S104	Sugiyama	ANP32D PP32R2	AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
P00558	S390	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	IIGGGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPG
P00558	T394	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406	S210	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	S312	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA
P04406	S321	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE______
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S78	Sugiyama	HSPB1 HSP27 HSP28	LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792	S83	Sugiyama	HSPB1 HSP27 HSP28	IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P05362	S43	Sugiyama	ICAM1	GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05387	S29	Sugiyama	RPLP2 D11S2243E RPP2	LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P05388	S304	Sugiyama	RPLP0	AttAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
P05783	S93	Sugiyama	KRT18 CYK18 PIG46	GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P05787	S330	Sugiyama	KRT8 CYK8	MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P06733	S37	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06733	S40	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195	S44	Sugiyama	LDHB	ITVVGVGQVGMACAISILGKsLADELALVDVLEDKLKGEMM
P07205	S390	Sugiyama	PGK2 PGKB	VIGGGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPG
P07205	T394	Sugiyama	PGK2 PGKB	GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07237	S427	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07355	S184	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07437	S75	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07437	T72	Sugiyama	TUBB TUBB5 OK/SW-cl.56	NEAtGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
P07814	S747	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	ETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVREL
P07900	S468	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	GIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKENQ
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	T467	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKEN
P08238	S45	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238	S460	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S48	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238	T297	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238	T467	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08670	S83	SIGNOR\|iPTMNet	VIM	tRssAVRLRssVPGVRLLQDsVDFsLADAINTEFKNTRTNE
P09104	S37	Sugiyama	ENO2	NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY
P09104	S40	Sugiyama	ENO2	VEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGK
P09104	T19	Sugiyama	ENO2	__MSIEKIWAREILDSRGNPtVEVDLyTAKGLFRAAVPsGA
P09104	Y25	Sugiyama	ENO2	KIWAREILDSRGNPtVEVDLyTAKGLFRAAVPsGAstGIyE
P09382	S63	Sugiyama	LGALS1	CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09651	S22	Sugiyama	HNRNPA1 HNRPA1	sKsEsPKEPEQLRKLFIGGLsFEtTDESLRSHFEQWGTLTD
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09651	T25	Sugiyama	HNRNPA1 HNRPA1	EsPKEPEQLRKLFIGGLsFEtTDESLRSHFEQWGTLTDCVV
P0CG41	S140	Sugiyama	CTAGE8	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412	S86	Sugiyama	H1-4 H1F4 HIST1H1E	LAAAGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFK
P10412	S89	Sugiyama	H1-4 H1F4 HIST1H1E	AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P10412	T92	Sugiyama	H1-4 H1F4 HIST1H1E	DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P10809	S488	Sugiyama	HSPD1 HSP60	IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P11717	S1378	Sugiyama	IGF2R MPRI	QYACPPFDLTECSFKDGAGNsFDLsSLSRYSDNWEAITGTG
P12268	S416	Sugiyama	IMPDH2 IMPD2	APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P13073	S74	Sugiyama	COX4I1 COX4	HLSASQKALKEKEKASWssLsMDEKVELYRIKFKEsFAEMN
P13639	T5	Sugiyama	EEF2 EF2	________________MVNFtVDQIRAIMDKKANIRNMsVI
P13688	T457	SIGNOR\|EPSD	CEACAM1 BGP BGP1	VVALVALIAVALACFLHFGKtGRAsDQRDLtEHKPsVSNHT
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P13929	S37	Sugiyama	ENO3	NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY
P13929	S40	Sugiyama	ENO3	VEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGK
P14625	S106	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625	S109	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625	S514	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625	S515	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14625	S523	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	RtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIyFMAG
P14854	S52	Sugiyama	COX6B1 COX6B	QNyLDFHRCQKAMTAKGGDIsVCEWyQRVYQsLCPtsWVTD
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311	S536	Sugiyama	EZR VIL2	KRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNE
P15311	S539	Sugiyama	EZR VIL2	TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15336	S62	Sugiyama	ATF2 CREB2 CREBP1	LAVHKHKHEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEV
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16070	S71	Sugiyama	CD44 LHR MDU2 MDU3 MIC4	DLCKAFNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRI
P16401	S89	Sugiyama	H1-5 H1F5 HIST1H1B	LAAGGYDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFK
P16401	S92	Sugiyama	H1-5 H1F5 HIST1H1B	GGYDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16401	T95	Sugiyama	H1-5 H1F5 HIST1H1B	DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402	S87	Sugiyama	H1-3 H1F3 HIST1H1D	LAAAGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFK
P16402	S90	Sugiyama	H1-3 H1F3 HIST1H1D	AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16402	T93	Sugiyama	H1-3 H1F3 HIST1H1D	DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	S86	Sugiyama	H1-2 H1F2 HIST1H1C	LAAAGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFK
P16403	S89	Sugiyama	H1-2 H1F2 HIST1H1C	AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16403	T92	Sugiyama	H1-2 H1F2 HIST1H1C	DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16949	S46	Sugiyama	STMN1 C1orf215 LAP18 OP18	PRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAEERRKsHEA
P17096	S102	Sugiyama	HMGA1 HMGIY	KPRGRPKKLEKEEEEGIsQEssEEEQ_______________
P17096	S99	Sugiyama	HMGA1 HMGIY	PGRKPRGRPKKLEKEEEEGIsQEssEEEQ____________
P17544	S44	Sugiyama	ATF7 ATFA	LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P18615	S115	Sugiyama	NELFE RD RDBP	KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18615	S131	Sugiyama	NELFE RD RDBP	QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18615	S135	Sugiyama	NELFE RD RDBP	sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18615	S165	Sugiyama	NELFE RD RDBP	ELGPDGEEAEGPGAGDGPPRsFDWGyEERSGAHSsAsPPRs
P18615	Y133	Sugiyama	NELFE RD RDBP	sIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEA
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P18621	T79	Sugiyama	RPL17	PFRRYNGGVGRCAQAKQWGWtQGRWPKKSAEFLLHMLKNAE
P19338	S458	Sugiyama	NCL	TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338	S580	Sugiyama	NCL	PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P19338	S619	Sugiyama	NCL	RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P20042	S67	Sugiyama	EIF2S2 EIF2B	EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK
P22090	S204	Sugiyama	RPS4Y1 RPS4Y PRO2646	IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626	S212	Sugiyama	HNRNPA2B1 HNRPA2B1	EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23528	S41	Sugiyama	CFL1 CFL	RKsstPEEVKKRKKAVLFCLsEDKKNIILEEGKEILVGDVG
P23528	T63	Sugiyama	CFL1 CFL	DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528	T70	Sugiyama	CFL1 CFL	EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588	S597	Sugiyama	EIF4B	KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______
P23921	S780	Sugiyama	RRM1 RR1	KEKVSKEEEEKERNtAAMVCsLENRDECLMCGS________
P24534	S141	Sugiyama	EEF1B2 EEF1B EF1B	ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25054	S1861	Sugiyama	APC DP2.5	DsPHHytPIEGTPYCFsRNDsLssLDFDDDDVDLSREKAEL
P25054	S2129	Sugiyama	APC DP2.5	NSIVSSLHQAAAAACLsRQAssDSDSILSLKsGIsLGsPFH
P25705	S65	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	KtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARVH
P26038	S527	Sugiyama	MSN	ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26038	T526	Sugiyama	MSN	EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T148	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373	T151	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26678	S16	GPS6	PLN PLB	_____MEKVQYLTRSAIRRAstIEMPQQARQKLQNLFINFC
P26678	T17	GPS6	PLN PLB	____MEKVQYLTRSAIRRAstIEMPQQARQKLQNLFINFCL
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29401	S295	Sugiyama	TKT	ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29692	S74	Sugiyama	EEF1D EF1D	RENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVENQsL
P29692	S86	Sugiyama	EEF1D EF1D	GPGAssGtsGDHGELVVRIAsLEVENQsLRGVVQELQQAIs
P30043	T190	Sugiyama	BLVRB FLR SCAN	RGPSRVISKHDLGHFMLRCLttDEyDGHstyPsHQyQ____
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30086	T167	Sugiyama	PEBP1 PBP PEBP	GKFKVAsFRKKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK
P30086	T51	Sugiyama	PEBP1 PBP PEBP	GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P30101	S474	Sugiyama	PDIA3 ERP57 ERP60 GRP58	yFsPANKKLNPKKyEGGRELsDFIsyLQREAtNPPVIQEEK
P30101	S478	Sugiyama	PDIA3 ERP57 ERP60 GRP58	ANKKLNPKKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKK
P30533	S242	Sugiyama	LRPAP1 A2MRAP	TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30533	S247	Sugiyama	LRPAP1 A2MRAP	KLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQSA
P30533	Y246	Sugiyama	LRPAP1 A2MRAP	EKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQS
P31327	S564	Sugiyama	CPS1	TEDRQLFSDKLNEINEKIAPsFAVEsIEDALKAADTIGyPV
P31327	S569	Sugiyama	CPS1	LFSDKLNEINEKIAPsFAVEsIEDALKAADTIGyPVMIRSA
P31943	S23	Sugiyama	HNRNPH1 HNRPH HNRPH1	LGTEGGEGFVVKVRGLPWsCsADEVQRFFSDCKIQNGAQGI
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P31947	S69	Sugiyama	SFN HME1	KNVVGGQRAAWRVLSsIEQKsNEEGsEEKGPEVREYREKVE
P32119	T142	Sugiyama	PRDX2 NKEFB TDPX1	EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P35269	T154	Sugiyama	GTF2F1 RAP74	AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35637	S340	Sugiyama	FUS TLS	PMINLyTDRETGKLKGEAtVsFDDPPsAKAAIDWFDGKEFs
P35637	T338	Sugiyama	FUS TLS	GQPMINLyTDRETGKLKGEAtVsFDDPPsAKAAIDWFDGKE
P36578	S87	Sugiyama	RPL4 RPL1	WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578	T84	Sugiyama	RPL4 RPL1	AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P37108	T45	Sugiyama	SRP14	sVyItLKKYDGRTKPIPKKGtVEGFEPADNKCLLRATDGKK
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P39019	S59	Sugiyama	RPS19	LAKHKELAPyDENWFytRAAstARHLYLRGGAGVGsMTKIY
P39019	Y48	Sugiyama	RPS19	LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P39023	S304	Sugiyama	RPL3 OK/SW-cl.32	IYKIGQGyLIKDGKLIKNNAstDyDLSDKSINPLGGFVHYG
P39687	S104	Sugiyama	ANP32A C15orf1 LANP MAPM PHAP1	AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P39687	S117	Sugiyama	ANP32A C15orf1 LANP MAPM PHAP1	GNKIKDLstIEPLKKLENLKsLDLFNCEVtNLNDyRENVFK
P39748	S255	Sugiyama	FEN1 RAD2	CESIRGIGPKRAVDLIQKHKsIEEIVRRLDPNKYPVPENWL
P41236	S121	Sugiyama	PPP1R2 IPP2	ARKLAAAEGLEPKyRIQEQEssGEEDsDLsPEEREKKRQFE
P42677	S78	Sugiyama	RPS27 MPS1	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P42677	T74	Sugiyama	RPS27 MPS1	VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490	S472	Sugiyama	NAMPT PBEF PBEF1	EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46087	S36	Sugiyama	NOP2 NOL1 NSUN1	RKARKQKGAEtELVRFLPAVsDENsKRLsSRARKRAAKRRL
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46776	T72	Sugiyama	RPL27A	yFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRVNAAK
P46777	S172	Sugiyama	RPL5 MSTP030	RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777	S176	Sugiyama	RPL5 MSTP030	GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46937	S109	Sugiyama	YAP1 YAP65	RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P47914	S142	Sugiyama	RPL29	KAKAKAKAKDQTKAQAAAPAsVPAQAPKRtQAPtKAsE___
P49327	S1597	Sugiyama	FASN FAS	MLATGKLsPDAIPGKWTSQDsLLGMEFSGRDASGKRVMGLV
P50454	S139	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P50454	S141	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	STARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHSKI
P50454	Y135	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	LRSLSNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYN
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51787	S484	SIGNOR\|PSP	KCNQ1 KCNA8 KCNA9 KVLQT1	sVRKsPtLLEVSMPHFMRtNsFAEDLDLEGETLLTPITHIS
P51787	T482	PSP	KCNQ1 KCNA8 KCNA9 KVLQT1	DSsVRKsPtLLEVSMPHFMRtNsFAEDLDLEGETLLTPITH
P51858	S83	Sugiyama	HDGF HMG1L2	LFPyEEsKEKFGKPNKRKGFsEGLWEIENNPtVKASGYQSs
P52272	S528	Sugiyama	HNRNPM HNRPM NAGR1	IERMGsGVERMGPAIERMGLsMERMVPAGMGAGLERMGPVM
P52272	S618	Sugiyama	HNRNPM HNRPM NAGR1	PALGAGIERMGLAMGGGGGAsFDRAIEMERGNFGGsFAGsF
P52298	S13	Sugiyama	NCBP2 CBP20 PIG55	________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52907	S106	Sugiyama	CAPZA1	RFLDPRNKISFKFDHLRKEAsDPQPEEADGGLKsWREsCDs
P52948	S683	Sugiyama	NUP98 ADAR2	IAKPIPQtPEsAGNKHsNsNsVDDtIVALNMRAALRNGLEG
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999	S104	Sugiyama	SUB1 PC4 RPO2TC1	DIREYWMDPEGEMKPGRKGIsLNPEQWsQLKEQIsDIDDAV
P53999	S111	Sugiyama	SUB1 PC4 RPO2TC1	DPEGEMKPGRKGIsLNPEQWsQLKEQIsDIDDAVRKL____
P53999	S118	Sugiyama	SUB1 PC4 RPO2TC1	PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999	S12	Sugiyama	SUB1 PC4 RPO2TC1	_________MPKSKELVsssssGsDsDsEVDKKLKRKKQVA
P54105	Y214	Sugiyama	CLNS1A CLCI ICLN	QsVssQYNMAGVRtEDsIRDyEDGMEVDttPtVAGQFEDAD
P55081	S133	Sugiyama	MFAP1	VGEsDsEVEGDAWRMEREDssEEEEEEIDDEEIERRRGMMR
P55327	S176	SIGNOR\|PSP	TPD52	SVGSVITKKLEDVKNSPTFKsFEEKVENLKSKVGGTKPAGG
P56524	S210	SIGNOR\|EPSD\|PSP	HDAC4 KIAA0288	NLNHCIsSDPRYWYGKtQHssLDQssPPQsGVstsYNHPVL
P60174	S198	Sugiyama	TPI1 TPI	TPQQAQEVHEKLRGWLKsNVsDAVAQstRIIyGGsVtGAtC
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174	S97	Sugiyama	TPI1 TPI	GEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELIGQKVAHA
P60174	T217	Sugiyama	TPI1 TPI	VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	T201	Sugiyama	ACTB	AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL
P60709	T203	Sugiyama	ACTB	RDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALDF
P60709	Y240	Sugiyama	ACTB	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P61247	S236	Sugiyama	RPS3A FTE1 MFTL	KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61254	T8	Sugiyama	RPL26	_____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61353	S86	Sugiyama	RPL27	SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61978	S401	Sugiyama	HNRNPK HNRPK	GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978	S417	Sugiyama	HNRNPK HNRPK	DLAGsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITI
P61978	S420	Sugiyama	HNRNPK HNRPK	GsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITItGt
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	S38	Sugiyama	YWHAG	ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981	T31	Sugiyama	YWHAG	ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62072	S48	Sugiyama	TIMM10 TIM10	ACHRKCVPPHYKEAELSKGEsVCLDRCVSKYLDIHERMGKK
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62258	T229	Sugiyama	YWHAE	LsEEsyKDstLIMQLLRDNLtLWtsDMQGDGEEQNKEALQD
P62266	S45	Sugiyama	RPS23	KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA
P62269	S96	Sugiyama	RPS18 D6S218E	QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62424	T84	Sugiyama	RPL7A SURF-3 SURF3	QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62701	S204	Sugiyama	RPS4X CCG2 RPS4 SCAR	tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	Y242	Sugiyama	ACTA2 ACTSA ACTVS GIG46	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62857	S23	Sugiyama	RPS28	TSRVQPIKLARVTKVLGRtGsQGQCtQVRVEFMDDtsRsII
P62857	T28	Sugiyama	RPS28	PIKLARVTKVLGRtGsQGQCtQVRVEFMDDtsRsIIRNVKG
P62899	S15	Sugiyama	RPL31	______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899	T107	Sugiyama	RPL31	RLSRKRNEDEDsPNKLytLVtyVPVttFKNLQtVNVDEN__
P62899	T119	Sugiyama	RPL31	PNKLytLVtyVPVttFKNLQtVNVDEN______________
P62899	T26	Sugiyama	RPL31	KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917	S130	Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917	T135	Sugiyama	RPL8	CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62937	T157	Sugiyama	PPIA CYPA	NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62942	T22	Sugiyama	FKBP1A FKBP1 FKBP12	GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62979	S123	Sugiyama	RPS27A UBA80 UBCEP1	LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P62979	S134	Sugiyama	RPS27A UBA80 UBCEP1	IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63167	S21	Sugiyama	DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1	MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH
P63220	S31	Sugiyama	RPS21	LYVPRKCSASNRIIGAKDHAsIQMNVAEVDKVTGRFNGQFK
P63220	S65	Sugiyama	RPS21	RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	T201	Sugiyama	ACTG1 ACTG	AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL
P63261	T203	Sugiyama	ACTG1 ACTG	RDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALDF
P63261	Y240	Sugiyama	ACTG1 ACTG	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	Y241	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809	S102	Sugiyama	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809	S136	Sugiyama	YBX1 NSEP1 YB1	GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809	S209	Sugiyama	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809	T80	Sugiyama	YBX1 NSEP1 YB1	LGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIKKNNPRKyL
P67809	Y99	Sugiyama	YBX1 NSEP1 YB1	DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	Y242	Sugiyama	ACTC1 ACTC	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	Y242	Sugiyama	ACTA1 ACTA	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363	S439	Sugiyama	TUBA1B	SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68363	Y432	Sugiyama	TUBA1B	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731	S7	Sugiyama	RPL24	______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731	S86	Sugiyama	RPL24	EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731	T83	Sugiyama	RPL24	QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098	S13	Sugiyama	RPL19	________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEIA
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098	T29	Sugiyama	RPL19	RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
P98175	S733	Sugiyama	RBM10 DXS8237E GPATC9 GPATCH9 KIAA0122	LPKLAsDDRPsPPRGLVAAysGEsDsEEEQERGGPEREEKL
Q00688	T11	Sugiyama	FKBP3 FKBP25	__________MAAAVPQRAWtVEQLRSEQLPKKDIIKFLQE
Q00839	S59	Sugiyama	HNRNPU C1orf199 HNRPU SAFA U21.1	QAALDDEEAGGRPAMEPGNGsLDLGGDsAGRSGAGLEQEAA
Q01650	S35	Sugiyama	SLC7A5 CD98LC LAT1 MPE16	AAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNITLLNG
Q02539	S89	Sugiyama	H1-1 H1F1 HIST1H1A	LAAAGyDVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFK
Q02539	S92	Sugiyama	H1-1 H1F1 HIST1H1A	AGyDVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNK
Q02539	T95	Sugiyama	H1-1 H1F1 HIST1H1A	DVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNKKAS
Q02543	S123	Sugiyama	RPL18A	AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q02878	T118	Sugiyama	RPL6 TXREB1	GDKNGGTRVVKLRKMPRyyPtEDVPRKLLSHGKKPFSQHVR
Q02878	Y116	Sugiyama	RPL6 TXREB1	VGGDKNGGTRVVKLRKMPRyyPtEDVPRKLLSHGKKPFSQH
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05682	S58	Sugiyama	CALD1 CAD CDM	ARERRRRARQERLRQKQEEEsLGQVTDQVEVNAQNsVPDEE
Q06830	S152	Sugiyama	PRDX1 PAGA PAGB TDPX2	IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q06830	T143	Sugiyama	PRDX1 PAGA PAGB TDPX2	EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07020	S140	Sugiyama	RPL18	ILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAPGtPH
Q07020	T136	Sugiyama	RPL18	AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020	T85	Sugiyama	RPL18	RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q07157	S1051	Sugiyama	TJP1 ZO1	PDKEPNLTyEPQLPYVEKQAsRDLEQPtyRyEsssytDQFs
Q07666	S20	Sugiyama	KHDRBS1 SAM68	_MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q08289	T554	SIGNOR	CACNB2 CACNLB2 MYSB	sSAPHHNHRSGTSRGLSRQEtFDSETQESRDSAYVEPKEDY
Q08AD1	S1313	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	sLNtGDNEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWE
Q12830	S1310	Sugiyama	BPTF FAC1 FALZ	DRVLDDVsIRsPEtKCPKQNsIENDIEEKVSDLASRGQEPS
Q13428	S88	Sugiyama	TCOF1	DAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRLAst
Q13435	S307	Sugiyama	SF3B2 SAP145	MNsQQEEEEMETDARssLGQsAsEtEEDtVsVsKKEKNRKR
Q13439	S41	Sugiyama	GOLGA4	APAQAssNsstPtRMRsRtssFtEQLDEGtPNRESGDTQSF
Q13442	S19	Sugiyama	PDAP1 HASPP28	__MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442	S63	Sugiyama	PDAP1 HASPP28	GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13442	T18	Sugiyama	PDAP1 HASPP28	___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13509	S75	Sugiyama	TUBB3 TUBB4	SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13509	T72	Sugiyama	TUBB3 TUBB4	NEASSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIF
Q13554	S26	Sugiyama	CAMK2B CAM2 CAMK2 CAMKB	TCTRFTDEYQLYEDIGKGAFsVVRRCVKLCTGHEYAAKIIN
Q13554	S280	Sugiyama	CAMK2B CAM2 CAMK2 CAMKB	RITAHEALKHPWVCQRstVAsMMHRQEtVECLKKFNARRKL
Q13554	T240	Sugiyama	CAMK2B CAM2 CAMK2 CAMKB	HKLYQQIKAGAyDFPsPEWDtVTPEAKNLINQMLTINPAKR
Q13554	T277	Sugiyama	CAMK2B CAM2 CAMK2 CAMKB	PAKRITAHEALKHPWVCQRstVAsMMHRQEtVECLKKFNAR
Q13554	T306	Sugiyama	CAMK2B CAM2 CAMK2 CAMKB	EtVECLKKFNARRKLKGAILttMLAtRNFSVGRQTtAPAtM
Q13554	T307	Sugiyama	CAMK2B CAM2 CAMK2 CAMKB	tVECLKKFNARRKLKGAILttMLAtRNFSVGRQTtAPAtMS
Q13554	T311	Sugiyama	CAMK2B CAM2 CAMK2 CAMKB	LKKFNARRKLKGAILttMLAtRNFSVGRQTtAPAtMSTAAS
Q13554	Y231	Sugiyama	CAMK2B CAM2 CAMK2 CAMKB	YPPFWDEDQHKLYQQIKAGAyDFPsPEWDtVTPEAKNLINQ
Q13555	S26	Sugiyama	CAMK2G CAMK CAMK-II CAMKG	TCTRFTDDYQLFEELGKGAFsVVRRCVKKTstQEYAAKIIN
Q13555	S280	Sugiyama	CAMK2G CAMK CAMK-II CAMKG	RITADQALKHPWVCQRstVAsMMHRQEtVECLRKFNARRKL
Q13555	T240	Sugiyama	CAMK2G CAMK CAMK-II CAMKG	HKLYQQIKAGAyDFPsPEWDtVTPEAKNLINQMLTINPAKR
Q13555	T277	Sugiyama	CAMK2G CAMK CAMK-II CAMKG	PAKRITADQALKHPWVCQRstVAsMMHRQEtVECLRKFNAR
Q13555	Y231	Sugiyama	CAMK2G CAMK CAMK-II CAMKG	YPPFWDEDQHKLYQQIKAGAyDFPsPEWDtVTPEAKNLINQ
Q13557	S26	Sugiyama	CAMK2D CAMKD	TCTRFTDEyQLFEELGKGAFsVVRRCMKIPTGQEYAAKIIN
Q13557	S264	Sugiyama	CAMK2D CAMKD	EAKDLINKMLTINPAKRItAsEALKHPWICQRstVAsMMHR
Q13557	S276	Sugiyama	CAMK2D CAMKD	NPAKRItAsEALKHPWICQRstVAsMMHRQEtVDCLKKFNA
Q13557	S280	Sugiyama	CAMK2D CAMKD	RItAsEALKHPWICQRstVAsMMHRQEtVDCLKKFNARRKL
Q13557	S315	iPTMNet\|Sugiyama	CAMK2D CAMKD	NARRKLKGAILttMLAtRNFsAAKsLLKKPDGVKEstEssN
Q13557	S319	iPTMNet	CAMK2D CAMKD	KLKGAILttMLAtRNFsAAKsLLKKPDGVKEstEssNttIE
Q13557	S330	Sugiyama	CAMK2D CAMKD	AtRNFsAAKsLLKKPDGVKEstEssNttIEDEDVKARKQEI
Q13557	S333	iPTMNet\|Sugiyama	CAMK2D CAMKD	NFsAAKsLLKKPDGVKEstEssNttIEDEDVKARKQEIIKV
Q13557	S334	iPTMNet\|Sugiyama	CAMK2D CAMKD	FsAAKsLLKKPDGVKEstEssNttIEDEDVKARKQEIIKVT
Q13557	T240	Sugiyama	CAMK2D CAMKD	HRLYQQIKAGAyDFPsPEWDtVTPEAKDLINKMLTINPAKR
Q13557	T262	Sugiyama	CAMK2D CAMKD	TPEAKDLINKMLTINPAKRItAsEALKHPWICQRstVAsMM
Q13557	T277	Sugiyama	CAMK2D CAMKD	PAKRItAsEALKHPWICQRstVAsMMHRQEtVDCLKKFNAR
Q13557	T287	GPS6\|EPSD\|PSP	CAMK2D CAMKD	LKHPWICQRstVAsMMHRQEtVDCLKKFNARRKLKGAILtt
Q13557	T306	Sugiyama	CAMK2D CAMKD	EtVDCLKKFNARRKLKGAILttMLAtRNFsAAKsLLKKPDG
Q13557	T307	GPS6\|Sugiyama	CAMK2D CAMKD	tVDCLKKFNARRKLKGAILttMLAtRNFsAAKsLLKKPDGV
Q13557	T311	Sugiyama	CAMK2D CAMKD	LKKFNARRKLKGAILttMLAtRNFsAAKsLLKKPDGVKEst
Q13557	T331	iPTMNet\|Sugiyama	CAMK2D CAMKD	tRNFsAAKsLLKKPDGVKEstEssNttIEDEDVKARKQEII
Q13557	T337	iPTMNet\|Sugiyama	CAMK2D CAMKD	AKsLLKKPDGVKEstEssNttIEDEDVKARKQEIIKVTEQL
Q13557	Y231	Sugiyama	CAMK2D CAMKD	YPPFWDEDQHRLYQQIKAGAyDFPsPEWDtVTPEAKDLINK
Q13573	T261	Sugiyama	SNW1 SKIIP SKIP	EQQEWKIPPCISNWKNAKGytIPLDKRLAADGRGLQTVHIN
Q13885	S75	Sugiyama	TUBB2A TUBB2	AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q13885	T72	Sugiyama	TUBB2A TUBB2	NEAAGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
Q14151	S613	Sugiyama	SAFB2 KIAA0138	ERSSKSQDRKSESKEKRDILsFDKIKEQRERERQRQREREI
Q14152	S1188	Sugiyama	EIF3A EIF3S10 KIAA0139	PWRPLVKPGGWREKEKAREEsWGPPRESRPsEEREWDREKE
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14157	T239	Sugiyama	UBAP2L KIAA0144 NICE4	GNTWNNTGHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIF
Q14157	T241	Sugiyama	UBAP2L KIAA0144 NICE4	TWNNTGHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIFtA
Q14157	T246	Sugiyama	UBAP2L KIAA0144 NICE4	GHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIFtAsNVss
Q14192	S238	Sugiyama	FHL2 DRAL SLIM3	AKKCAGCTNPISGLGGtKyIsFEERQWHNDCFNCKKCsLsL
Q14247	S282	Sugiyama	CTTN EMS1	QKDyKTGFGGKFGVQsERQDsAAVGFDyKEKLAKHEsQQDy
Q14247	S322	Sugiyama	CTTN EMS1	ySKGFGGKyGVQKDRMDKNAstFEDVtQVssAyQKTVPVEA
Q14524	S1934	SIGNOR	SCN5A	RHLLQRsLKHAsFLFRQQAGsGLsEEDAPEREGLIAYVMSE
Q14524	S1985	SIGNOR	SCN5A	SSSISSTSFPPSYDSVTRATsDNLQVRGSDYSHsEDLADFP
Q14524	S516	SIGNOR\|EPSD\|PSP	SCN5A	KsDsEDGPRAMNHLsLTRGLsRTSMKPRssRGsIFTFRRRD
Q14524	S571	SIGNOR	SCN5A	AGESESHHTSLLVPWPLRRtsAQGQPsPGTSAPGHALHGKK
Q14524	T594	SIGNOR\|EPSD\|PSP	SCN5A	GQPsPGTSAPGHALHGKKNStVDCNGVVSLLGAGDPEATSP
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14571	S150	SIGNOR	ITPR2	KYLTVNKRLPALLEKNAMRVsLDAAGNEGSWFYIHPFWKLR
Q14654	T224	SIGNOR\|EPSD\|PSP	KCNJ11	DLRKSMIISATIHMQVVRKTtSPEGEVVPLHQVDIPMENGV
Q14676	T449	Sugiyama	MDC1 KIAA0170 NFBD1	RDAEEDMPQRVVLLQRsQtttERDsDtDVEEEELPVENREA
Q14677	S164	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	RLREERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKW
Q14677	S166	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14847	S146	Sugiyama	LASP1 MLN50	FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q14847	S99	Sugiyama	LASP1 MLN50	ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q15084	S169	Sugiyama	PDIA6 ERP5 P5 TXNDC7	GKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFYAPW
Q15121	S116	Sugiyama	PEA15	DtKLtRIPsAKKYKDIIRQPsEEEIIKLAPPPKKA______
Q15139	S247	Sugiyama	PRKD1 PKD PKD1 PRKCM	PDEPLLQKsPsEsFIGREKRsNsQsyIGRPIHLDKILMSKV
Q15139	S249	Sugiyama	PRKD1 PKD PKD1 PRKCM	EPLLQKsPsEsFIGREKRsNsQsyIGRPIHLDKILMSKVKV
Q15139	S251	Sugiyama	PRKD1 PKD PKD1 PRKCM	LLQKsPsEsFIGREKRsNsQsyIGRPIHLDKILMSKVKVPH
Q15185	S113	Sugiyama	PTGES3 P23 TEBP	RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185	S82	Sugiyama	PTGES3 P23 TEBP	NDsKHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVD
Q15293	S69	Sugiyama	RCN1 RCN	PPEDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVD
Q16204	S323	Sugiyama	CCDC6 D10S170 TST1	RLQRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQ
Q16204	S328	Sugiyama	CCDC6 D10S170 TST1	LQREMERREALCRQLsEsEssLEMDDERYFNEMsAQGLRPR
Q16625	S471	EPSD\|PSP	OCLN	DEINKELSRLDKELDDYREEsEEyMAAADEYNRLKQVKGsA
Q16626	S163	Sugiyama	MEA1 MEA	RTMAGVSLPAPGVPAWAREIsDAQWEDVVQKALQARQAsPA
Q32P51	S22	Sugiyama	HNRNPA1L2 HNRNPA1L	SKSASPKEPEQLRKLFIGGLsFEtTDESLRSHFEQWGTLTD
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q32P51	T25	Sugiyama	HNRNPA1L2 HNRNPA1L	ASPKEPEQLRKLFIGGLsFEtTDESLRSHFEQWGTLTDCVV
Q3ZCM7	S75	Sugiyama	TUBB8	SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC
Q3ZCM7	T72	Sugiyama	TUBB8	NEASGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIF
Q562R1	Y241	Sugiyama	ACTBL2	ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q5SW79	S881	Sugiyama	CEP170 FAM68A KAB KIAA0470	sstPssLALtsAsRIRERsEsLDPDssMDTtLILKDTEAVM
Q5VT52	S1177	Sugiyama	RPRD2 KIAA0460 HSPC099	GGLTGFKTAPYKERAPQFQEsVGsFRsNsFNstFEHHLPPs
Q6GYQ0	T798	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6P996	S724	Sugiyama	PDXDC1 KIAA0251	QKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQItL
Q6S8J3	Y940	Sugiyama	POTEE A26C1A POTE2	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q71U36	S439	Sugiyama	TUBA1A TUBA3	SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q71U36	Y432	Sugiyama	TUBA1A TUBA3	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71UM5	S78	Sugiyama	RPS27L	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q71UM5	T74	Sugiyama	RPS27L	VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q7LBC6	S816	Sugiyama	KDM3B C5orf7 JHDM2B JMJD1B KIAA1082	RFsLDERSLACRQDsDSSTNsDLSDLSDSEEQLQAKTGLKG
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z4V5	S369	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	EKERRRERADRGEAERGsGGssGDELREDDEPVKKRGRKGR
Q7Z7L8	S425	Sugiyama	C11orf96 AG2	RstQsLSLQREQLSSCKLRNsLDssDsDsAL__________
Q86UF2	S140	Sugiyama	CTAGE6 CTAGE6P	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86V81	S239	Sugiyama	ALYREF ALY BEF THOC4	tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86V81	S8	Sugiyama	ALYREF ALY BEF THOC4	_____________MADKMDMsLDDIIKLNRSQRGGRGGGRG
Q86V81	T148	Sugiyama	ALYREF ALY BEF THOC4	EFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQYNG
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86W56	S133	Sugiyama	PARG	VQKDNFyQHNVEKLENVsQLsLDKsPtEKSTQYLNQHQTAA
Q8IX94	S140	Sugiyama	CTAGE4	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8N3V7	S263	Sugiyama	SYNPO KIAA1029	HsMEGYSEEASLLRHLEKVAsEEEEVPLVVYLKENAALLTA
Q8N6H7	S368	Sugiyama	ARFGAP2 ZNF289 Nbla10535	VGTFASGPPKYKDNPFsLGEsFGsRWDTDAAWGMDRVEEKE
Q8N6H7	S432	Sugiyama	ARFGAP2 ZNF289 Nbla10535	RssGLEssEARQKFAGAKAIssDMFFGREVDAEyEARSRLQ
Q8N8S7	S125	Sugiyama	ENAH MENA	MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NE71	S140	Sugiyama	ABCF1 ABC50	PRGGKKTKGGNVFAALIQDQsEEEEEEEKHPPKPAKPEKNR
Q8NFH8	S631	Sugiyama	REPS2 POB1	AIQTAIRKNKEANAVLARLNsELQQQLKEVHQERIALENQL
Q8NHW5	S304	Sugiyama	RPLP0P6	DTTAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TEQ6	S757	Sugiyama	GEMIN5	PKAKPKKKKKPTLRtPVKLEsIDGNEEEsMKENsGPVENGV
Q8WVC0	T477	Sugiyama	LEO1 RDL	FDVYKAPLQGDHNHLFIRQGtGLQGQAVFKTKLTFRPHstD
Q8WWI1	S1510	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	RsAsVNKEPVSLPGIMRRGEsLDNLDsPRSNSWRQPPWLNQ
Q8WWI1	S706	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	RLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQK
Q8WWI1	T932	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	VtPRPFGsQtRGISsLPRsYtMDDAWKYNGDVEDIKRtPNN
Q8WX93	S479	Sugiyama	PALLD KIAA0992 CGI-151	VLECRVRGAPPLQVQWFRQGsEIQDsPDFRILQKKPRSTAE
Q8WZ42	S11878	EPSD\|PSP	TTN	KVRKLLPERKPEPKEEVVLKsVLRKRPEEEEPKVEPKKLEK
Q8WZ42	S12022	EPSD\|PSP	TTN	GVPKKTPSPIEAERRKLRPGsGGEKPPDEAPFTYQLKAVPL
Q8WZ42	T11922	PSP	TTN	PAVPEPPPPKPVEEVEVPTVtKRERKIPEPtKVPEIKPAIP
Q8WZ42	T11932	PSP	TTN	PVEEVEVPTVtKRERKIPEPtKVPEIKPAIPLPAPEPKPKP
Q8WZ42	T11969	PSP	TTN	KPKPEAEVKTIKPPPVEPEPtPIAAPVTVPVVGKKAEAKAP
Q92625	S663	Sugiyama	ANKS1A ANKS1 KIAA0229 ODIN	sRsEsLsNCsIGKKRLEKsPsFAsEWDEIEKIMssIGEGID
Q92688	S117	Sugiyama	ANP32B APRIL PHAPI2	GNKLKDIstLEPLKKLECLKsLDLFNCEVtNLNDyREsVFK
Q92736	S2808	EPSD	RYR2	RIERTREGDSMALYNRTRRIsQTSQVsVDAAHGYSPRAIDM
Q92736	S2814	EPSD	RYR2	EGDSMALYNRTRRIsQTSQVsVDAAHGYSPRAIDMSNVTLS
Q92769	S424	Sugiyama	HDAC2	KRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGAKK
Q92804	S289	Sugiyama	TAF15 RBP56 TAF2N	PMINLYTDKDTGKPKGEAtVsFDDPPsAKAAIDWFDGKEFH
Q92804	T287	Sugiyama	TAF15 RBP56 TAF2N	GKPMINLYTDKDTGKPKGEAtVsFDDPPsAKAAIDWFDGKE
Q93045	S80	Sugiyama	STMN2 SCG10 SCGN10	PPsPISEAPRTLAsPKKKDLsLEEIQKKLEAAEERRKsQEA
Q96D71	S767	Sugiyama	REPS1	AIQAsIRRNKETNTVLARLNsELQQQLKDVLEERISLEVQL
Q96E11	S239	Sugiyama	MRRF	LKKSKDTVsEDtIRLIEKQIsQMADDtVAELDRHLAVKTKE
Q96MH2	S194	Sugiyama	HEXIM2 L3	EAGDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELV
Q96MH2	T196	Sugiyama	HEXIM2 L3	GDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELVRD
Q96S59	S714	Sugiyama	RANBP9 RANBPM	QPPLALAMGQATQCLGLMARsGIGSCAFAtVEDYLH_____
Q96S59	T723	Sugiyama	RANBP9 RANBPM	QATQCLGLMARsGIGSCAFAtVEDYLH______________
Q96ST3	S158	Sugiyama	SIN3A	GSQPQVYNDFLDIMKEFKSQsIDtPGVISRVSQLFKGHPDL
Q99613	S39	Sugiyama	EIF3C EIF3S8	GEELVTKPVGGNyGKQPLLLsEDEEDTKRVVRSAKDKRFEE
Q99613	S865	Sugiyama	EIF3C EIF3S8	HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99618	S94	Sugiyama	CDCA3 C8 GRCC8 TOME1	ARtPMKTSsGDPPsPLVKQLsEVFETEDSKSNLPPEPVLPP
Q99755	S486	Sugiyama	PIP5K1A	GssFSRRAGssGNsCItyQPsVsGEHKAQVTTKAEVEPGVH
Q9BTE6	S174	Sugiyama	AARSD1	IEQSVNEKIRDRLPVNVRELsLDDPEVEQVsGRGLPDDHAG
Q9BVA1	S75	Sugiyama	TUBB2B	tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BVA1	T72	Sugiyama	TUBB2B	NEAtGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
Q9BY44	S526	Sugiyama	EIF2A CDA02 MSTP004 MSTP089	sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BYX7	Y240	Sugiyama	POTEKP ACTBL3 FKSG30	ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BZI7	S166	Sugiyama	UPF3B RENT3B UPF3X	KRDTKVGtIDDDPEyRKFLEsyAtDNEKMTstPEtLLEEIE
Q9C0C2	S1620	Sugiyama	TNKS1BP1 KIAA1741 TAB182	ADsDAHLFQDSTEPRAsRVPssDEEVVEEPQsRRTRMsLGT
Q9C0C2	S435	Sugiyama	TNKS1BP1 KIAA1741 TAB182	DAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQG
Q9C0C2	S437	Sugiyama	TNKS1BP1 KIAA1741 TAB182	HLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQGsQ
Q9C0C2	S836	Sugiyama	TNKS1BP1 KIAA1741 TAB182	GVLTAQDRVVGKPAQLGtQRsQEADVQDWEFRKRDsQGtys
Q9C0C2	S899	Sugiyama	TNKS1BP1 KIAA1741 TAB182	RDVsLGDWEFGKRDsLGAyAsQDANEQGQDLGKRDHHGRys
Q9H1E3	S113	Sugiyama	NUCKS1 NUCKS JC7	RQAASKAASKQREMLMEDVGsEEEQEEEDEAPFQEKDsGsD
Q9H444	T85	Sugiyama	CHMP4B C20orf178 SHAX1	ALQALKRKKRYEKQLAQIDGtLstIEFQREALENANtNtEV
Q9H444	T88	Sugiyama	CHMP4B C20orf178 SHAX1	ALKRKKRYEKQLAQIDGtLstIEFQREALENANtNtEVLKN
Q9H6S3	S693	Sugiyama	EPS8L2 EPS8R2 PP13181	EGVRVySQLTMQKAFLEKQQsGSELEELMNKFHSMNQRRGE
Q9HCN8	T70	Sugiyama	SDF2L1 UNQ1941/PRO4424	RVRLHSHDIKYGSGSGQQSVtGVEAsDDANSyWRIRGGSEG
Q9NP61	S366	Sugiyama	ARFGAP3 ARFGAP1	DDsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKD
Q9NP61	S367	Sugiyama	ARFGAP3 ARFGAP1	DsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKDT
Q9NR30	S706	Sugiyama	DDX21	PTASVTEIQEKWHDSRRWQLsVATEQPELEGPREGYGGFRG
Q9NUU7	T467	Sugiyama	DDX19A DDX19L	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UHA3	S68	Sugiyama	RSL24D1 C15orf15 RPL24L My024	KVRWTKAFRKAAGKELtVDNsFEFEKRRNEPIKYQRELWNK
Q9UHA3	T64	Sugiyama	RSL24D1 C15orf15 RPL24L My024	RNPRKVRWTKAFRKAAGKELtVDNsFEFEKRRNEPIKYQRE
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UKY7	S106	Sugiyama	CDV3 H41	KELEQKEVDysGLRVQAMQIssEKEEDDNEKRQDPGDNWEE
Q9ULD2	S1203	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9ULD2	T1204	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	ENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRLs
Q9UMR2	T468	Sugiyama	DDX19B DBP5 DDX19 TDBP	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UNX3	T8	Sugiyama	RPL26L1 RPL26P1	_____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UNZ2	S176	Sugiyama	NSFL1C UBXN2C	RLGAAPEEEsAyVAGEKRQHssQDVHVVLKLWKsGFsLDNG
Q9UNZ2	S192	Sugiyama	NSFL1C UBXN2C	KRQHssQDVHVVLKLWKsGFsLDNGELRSyQDPsNAQFLEs
Q9UPQ0	S201	Sugiyama	LIMCH1 KIAA1102	DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UPR0	T584	Sugiyama	PLCL2 KIAA1092 PLCE2	KILIKAKKLsSNCSGVEGDVtDEDEGAEMSQRMGKENMEQP
Q9UQ35	S854	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sHSsssPHPKVKsGtPPRQGsItsPQANEQsVtPQRRsCFE
Q9UQD0	S561	SIGNOR	SCN8A MED	sIMNQSLLSIPGSPFLSRHNsKSSIFSFRGPGRFRDPGSEN
Q9UQD0	S641	SIGNOR	SCN8A MED	SQGSRSSRIFPSLRRSVKRNstVDCNGVVSLIGGPGSHIGG
Q9UQD0	T642	SIGNOR	SCN8A MED	QGSRSSRIFPSLRRSVKRNstVDCNGVVSLIGGPGSHIGGR
Q9UQM7	S25	Sugiyama	CAMK2A CAMKA KIAA0968	TCTRFTEEYQLFEELGKGAFsVVRRCVKVLAGQEYAAKIIN
Q9UQM7	T239	Sugiyama	CAMK2A CAMKA KIAA0968	HRLYQQIKAGAyDFPsPEWDtVTPEAKDLINKMLtINPsKR
Q9UQM7	T305	Sugiyama	CAMK2A CAMKA KIAA0968	EtVDCLKKFNARRKLKGAILttMLAtRNFsGGKSGGNKKSD
Q9UQM7	T306	Sugiyama	CAMK2A CAMKA KIAA0968	tVDCLKKFNARRKLKGAILttMLAtRNFsGGKSGGNKKSDG
Q9UQM7	T310	Sugiyama	CAMK2A CAMKA KIAA0968	LKKFNARRKLKGAILttMLAtRNFsGGKSGGNKKSDGVKEs
Q9UQM7	Y230	Sugiyama	CAMK2A CAMKA KIAA0968	YPPFWDEDQHRLYQQIKAGAyDFPsPEWDtVTPEAKDLINK
Q9Y237	S72	Sugiyama	PIN4	MEAMEKLKSGMRFNEVAAQysEDKARQGGDLGWMTRGSMVG
Q9Y285	S352	Sugiyama	FARSA FARS FARSL FARSLA	SARALYRLAQKKPFTPVKYFsIDRVFRNETLDATHLAEFHQ
Q9Y2B0	S115	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0	S116	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2T7	S137	Sugiyama	YBX2 CSDA3 MSY2	EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA
Q9Y2T7	T115	Sugiyama	YBX2 CSDA3 MSY2	LGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIKRNNPRKFL
Q9Y2T7	T143	Sugiyama	YBX2 CSDA3 MSY2	QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y383	S347	Sugiyama	LUC7L2 CGI-59 CGI-74	SRERSKRRSSKERFRDQDLAsCDRDRssRDRSPRDRDRKDK
Q9Y3T9	S673	Sugiyama	NOC2L NIR	MADRKDEDRKQFKDLFDLNssEEDDtEGFsERGILRPLStR
Q9Y3U8	S91	Sugiyama	RPL36	KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y4L1	S742	Sugiyama	HYOU1 GRP170 HSPH4 ORP150	KLQDLTLRDLEKQEREKAANsLEAFIFEtQDKLyQPEyQEV
Q9Y4L1	T750	Sugiyama	HYOU1 GRP170 HSPH4 ORP150	DLEKQEREKAANsLEAFIFEtQDKLyQPEyQEVsTEEQREE
Q9Y5A9	S394	Sugiyama	YTHDF2 HGRG8	SQAGSGStPSEPHPVLEKLRsINNYNPKDFDWNLKHGRVFI
Q9Y5B9	S650	Sugiyama	SUPT16H FACT140 FACTP140	KRYKTREAEEKEKEGIVKQDsLVINLNRsNPKLKDLYIRPN
Q9Y5L4	S57	Sugiyama	TIMM13 TIM13B TIMM13A TIMM13B	ELLQRMTDKCFRKCIGKPGGsLDNSEQKCIAMCMDRyMDAW
Q9Y5S9	S56	Sugiyama	RBM8A RBM8 HSPC114 MDS014	KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y608	S18	Sugiyama	LRRFIP2	___MGTPASGRKRTPVKDRFsAEDEALsNIAREAEARLAAK

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Apoptotic cleavage of cellular proteins	R-HSA-111465	0.000004	5.391	0	0
DAG and IP3 signaling	R-HSA-1489509	0.000032	4.501	1	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	0.000105	3.980	0	0
Oncogenic MAPK signaling	R-HSA-6802957	0.000129	3.891	1	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	0.000103	3.988	1	0
Apoptotic execution phase	R-HSA-75153	0.000120	3.920	0	0
NRAGE signals death through JNK	R-HSA-193648	0.000141	3.852	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	0.000206	3.686	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	0.000217	3.664	0	0
Post NMDA receptor activation events	R-HSA-438064	0.000211	3.676	1	0
Calmodulin induced events	R-HSA-111933	0.000217	3.663	1	0
CaM pathway	R-HSA-111997	0.000217	3.663	1	0
Cell-extracellular matrix interactions	R-HSA-446353	0.000237	3.625	0	0
Nervous system development	R-HSA-9675108	0.000267	3.574	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	0.000282	3.549	0	0
Ca-dependent events	R-HSA-111996	0.000391	3.408	1	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	0.000513	3.290	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	0.000515	3.288	0	0
G alpha (12/13) signalling events	R-HSA-416482	0.000510	3.292	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	0.000524	3.281	0	0
RET signaling	R-HSA-8853659	0.000647	3.189	0	0
Axon guidance	R-HSA-422475	0.000651	3.186	0	0
Signaling by Hippo	R-HSA-2028269	0.000729	3.137	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	0.000826	3.083	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	0.000902	3.045	1	1
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	0.000902	3.045	1	1
Signaling downstream of RAS mutants	R-HSA-9649948	0.000902	3.045	1	1
HSF1-dependent transactivation	R-HSA-3371571	0.000919	3.036	1	1
Signaling by RAS mutants	R-HSA-6802949	0.000902	3.045	1	0
PLC beta mediated events	R-HSA-112043	0.000915	3.038	1	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	0.001017	2.993	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	0.001117	2.952	1	0
Transcriptional Regulation by MECP2	R-HSA-8986944	0.001773	2.751	1	0
Regulation of MECP2 expression and activity	R-HSA-9022692	0.002121	2.673	1	1
Signaling by RAF1 mutants	R-HSA-9656223	0.002275	2.643	1	1
Developmental Lineages of the Mammary Gland	R-HSA-9924644	0.002263	2.645	0	0
G-protein mediated events	R-HSA-112040	0.002381	2.623	1	0
Death Receptor Signaling	R-HSA-73887	0.002400	2.620	0	0
Striated Muscle Contraction	R-HSA-390522	0.002626	2.581	0	0
Cell Cycle	R-HSA-1640170	0.002722	2.565	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	0.003050	2.516	0	0
Amplification of signal from the kinetochores	R-HSA-141424	0.003405	2.468	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	0.003405	2.468	0	0
Signaling by VEGF	R-HSA-194138	0.003414	2.467	0	0
Trafficking of AMPA receptors	R-HSA-399719	0.003815	2.418	1	1
Cellular response to heat stress	R-HSA-3371556	0.003734	2.428	1	0
MAPK family signaling cascades	R-HSA-5683057	0.003803	2.420	1	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	0.003882	2.411	1	1
Membrane Trafficking	R-HSA-199991	0.003925	2.406	0	0
Intracellular signaling by second messengers	R-HSA-9006925	0.004167	2.380	1	0
Signal Transduction	R-HSA-162582	0.004217	2.375	1	0
Rab regulation of trafficking	R-HSA-9007101	0.004524	2.344	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	0.005184	2.285	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	0.005108	2.292	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	0.005076	2.295	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	0.005364	2.270	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	0.005708	2.244	1	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	0.005708	2.244	1	0
Nuclear Envelope Breakdown	R-HSA-2980766	0.005795	2.237	0	0
Nephrin family interactions	R-HSA-373753	0.006003	2.222	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	0.006481	2.188	0	0
Resolution of D-Loop Structures	R-HSA-5693537	0.006899	2.161	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	0.007531	2.123	1	1
AKT-mediated inactivation of FOXO1A	R-HSA-211163	0.008140	2.089	0	0
Muscle contraction	R-HSA-397014	0.009103	2.041	1	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	0.009603	2.018	1	1
Attenuation phase	R-HSA-3371568	0.009551	2.020	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	0.009789	2.009	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	0.010561	1.976	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	0.010561	1.976	0	0
PKA activation in glucagon signalling	R-HSA-164378	0.011228	1.950	0	0
PKA activation	R-HSA-163615	0.011228	1.950	0	0
FLT3 Signaling	R-HSA-9607240	0.011199	1.951	0	0
Protein-protein interactions at synapses	R-HSA-6794362	0.011496	1.939	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	0.011896	1.925	0	0
Glycolysis	R-HSA-70171	0.011835	1.927	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	0.012129	1.916	0	0
mRNA Splicing	R-HSA-72172	0.012614	1.899	0	0
Neurexins and neuroligins	R-HSA-6794361	0.013247	1.878	0	0
ISG15 antiviral mechanism	R-HSA-1169408	0.013759	1.861	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	0.014276	1.845	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	0.014286	1.845	0	0
RSK activation	R-HSA-444257	0.015056	1.822	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	0.015056	1.822	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	0.015635	1.806	0	0
Cell Cycle, Mitotic	R-HSA-69278	0.016828	1.774	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	0.016418	1.785	0	0
Regulation of gene expression in beta cells	R-HSA-210745	0.017467	1.758	0	0
Deadenylation of mRNA	R-HSA-429947	0.017771	1.750	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	0.018656	1.729	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	0.018656	1.729	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	0.019035	1.720	0	0
RAF activation	R-HSA-5673000	0.019758	1.704	1	1
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	0.021069	1.676	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	0.020983	1.678	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	0.021069	1.676	0	0
Long-term potentiation	R-HSA-9620244	0.021374	1.670	1	1
Cell Cycle Checkpoints	R-HSA-69620	0.020745	1.683	0	0
Sensory processing of sound	R-HSA-9659379	0.021096	1.676	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	0.021560	1.666	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	0.021566	1.666	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	0.023019	1.638	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	0.023315	1.632	0	0
PKMTs methylate histone lysines	R-HSA-3214841	0.024798	1.606	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	0.024643	1.608	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	0.024643	1.608	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	0.024833	1.605	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	0.028133	1.551	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	0.028133	1.551	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	0.028133	1.551	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	0.028133	1.551	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	0.028133	1.551	0	0
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	0.028133	1.551	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	0.027863	1.555	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	0.030567	1.515	0	0
Ephrin signaling	R-HSA-3928664	0.031956	1.495	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	0.031378	1.503	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	0.030103	1.521	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	0.030103	1.521	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	0.030691	1.513	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	0.028334	1.548	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	0.032115	1.493	0	0
Mitotic Prometaphase	R-HSA-68877	0.030559	1.515	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	0.027863	1.555	0	0
CREB phosphorylation	R-HSA-199920	0.030567	1.515	0	0
Opioid Signalling	R-HSA-111885	0.029394	1.532	1	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	0.030691	1.513	0	0
RAF/MAP kinase cascade	R-HSA-5673001	0.025937	1.586	1	1
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	0.026150	1.583	1	1
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	0.032303	1.491	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	0.033032	1.481	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	0.036431	1.439	1	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	0.036944	1.432	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	0.037279	1.429	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	0.038687	1.412	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	0.038089	1.419	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	0.041137	1.386	0	0
EPHB-mediated forward signaling	R-HSA-3928662	0.041308	1.384	0	0
Netrin-1 signaling	R-HSA-373752	0.041308	1.384	0	0
Rap1 signalling	R-HSA-392517	0.038687	1.412	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	0.040385	1.394	0	0
Signaling by ALK in cancer	R-HSA-9700206	0.040385	1.394	0	0
Glucose metabolism	R-HSA-70326	0.038256	1.417	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	0.042218	1.375	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	0.043866	1.358	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	0.043866	1.358	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	0.043866	1.358	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	0.047111	1.327	0	0
Activation of RAC1	R-HSA-428540	0.047111	1.327	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	0.046283	1.335	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	0.046283	1.335	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	0.046283	1.335	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	0.046283	1.335	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	0.046283	1.335	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	0.046283	1.335	0	0
Semaphorin interactions	R-HSA-373755	0.046891	1.329	0	0
Regulation of CDH1 Function	R-HSA-9764561	0.047066	1.327	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	0.046891	1.329	0	0
Signaling by PTK6	R-HSA-8848021	0.046891	1.329	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	0.042431	1.372	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	0.047426	1.324	0	0
Apoptosis	R-HSA-109581	0.047980	1.319	0	0
Cell-Cell communication	R-HSA-1500931	0.048268	1.316	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	0.049753	1.303	0	0
Interleukin-12 signaling	R-HSA-9020591	0.050154	1.300	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	0.051213	1.291	0	0
mRNA 3'-end processing	R-HSA-72187	0.052179	1.283	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	0.056043	1.251	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	0.058779	1.231	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	0.057623	1.239	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	0.057623	1.239	0	0
MAP2K and MAPK activation	R-HSA-5674135	0.057467	1.241	0	0
Separation of Sister Chromatids	R-HSA-2467813	0.053910	1.268	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	0.059289	1.227	0	0
TRP channels	R-HSA-3295583	0.059289	1.227	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	0.057356	1.241	0	0
Mitotic Anaphase	R-HSA-68882	0.054577	1.263	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	0.056043	1.251	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	0.056043	1.251	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	0.056043	1.251	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	0.054421	1.264	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	0.061159	1.214	0	0
G0 and Early G1	R-HSA-1538133	0.062053	1.207	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	0.063507	1.197	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	0.063507	1.197	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	0.063507	1.197	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	0.063507	1.197	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	0.063507	1.197	0	0
Homology Directed Repair	R-HSA-5693538	0.064121	1.193	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	0.064171	1.193	1	1
MTOR signalling	R-HSA-165159	0.064246	1.192	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	0.064246	1.192	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	0.064270	1.192	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	0.066220	1.179	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	0.066220	1.179	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	0.066446	1.178	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	0.072006	1.143	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	0.071947	1.143	0	0
Signaling by EGFR	R-HSA-177929	0.077095	1.113	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	0.072006	1.143	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	0.067742	1.169	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	0.075533	1.122	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	0.076296	1.117	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	0.072006	1.143	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	0.073807	1.132	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	0.077724	1.109	1	1
Regulation of RAS by GAPs	R-HSA-5658442	0.078392	1.106	0	0
Interleukin-12 family signaling	R-HSA-447115	0.078985	1.102	0	0
Polo-like kinase mediated events	R-HSA-156711	0.080867	1.092	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	0.080867	1.092	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	0.080867	1.092	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	0.080867	1.092	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	0.095284	1.021	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	0.095284	1.021	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	0.095284	1.021	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	0.095284	1.021	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	0.095284	1.021	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	0.095284	1.021	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	0.095284	1.021	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	0.095284	1.021	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	0.095284	1.021	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	0.095284	1.021	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	0.095284	1.021	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	0.095284	1.021	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	0.095284	1.021	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	0.095284	1.021	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	0.086491	1.063	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	0.086491	1.063	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	0.088093	1.055	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	0.099225	1.003	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	0.089089	1.050	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	0.100600	0.997	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	0.100087	1.000	0	0
M Phase	R-HSA-68886	0.094920	1.023	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	0.086462	1.063	1	0
Metabolism of RNA	R-HSA-8953854	0.088474	1.053	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	0.097872	1.009	0	0
Neuronal System	R-HSA-112316	0.095503	1.020	1	0
DARPP-32 events	R-HSA-180024	0.088093	1.055	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	0.087601	1.057	0	0
Interleukin-37 signaling	R-HSA-9008059	0.099225	1.003	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	0.100896	0.996	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	0.101351	0.994	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	0.102669	0.989	0	0
DCC mediated attractive signaling	R-HSA-418885	0.102669	0.989	0	0
PI Metabolism	R-HSA-1483255	0.102710	0.988	0	0
Drug resistance of KIT mutants	R-HSA-9669937	0.121178	0.917	0	0
KIT mutants bind TKIs	R-HSA-9669921	0.121178	0.917	0	0
Sorafenib-resistant KIT mutants	R-HSA-9669936	0.121178	0.917	0	0
Imatinib-resistant KIT mutants	R-HSA-9669917	0.121178	0.917	0	0
Sunitinib-resistant KIT mutants	R-HSA-9669934	0.121178	0.917	0	0
Masitinib-resistant KIT mutants	R-HSA-9669924	0.121178	0.917	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	0.121178	0.917	0	0
Regorafenib-resistant KIT mutants	R-HSA-9669929	0.121178	0.917	0	0
Dasatinib-resistant KIT mutants	R-HSA-9669914	0.121178	0.917	0	0
Nilotinib-resistant KIT mutants	R-HSA-9669926	0.121178	0.917	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	0.227677	0.643	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	0.227677	0.643	0	0
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	0.227677	0.643	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	0.227677	0.643	0	0
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	0.227677	0.643	0	0
STAT6-mediated induction of chemokines	R-HSA-3249367	0.137197	0.863	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	0.137197	0.863	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	0.112438	0.949	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	0.182240	0.739	0	0
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	0.182240	0.739	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	0.182240	0.739	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	0.182240	0.739	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	0.182240	0.739	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	0.182240	0.739	0	0
FGFR4 mutant receptor activation	R-HSA-1839128	0.321277	0.493	0	0
PI and PC transport between ER and Golgi membranes	R-HSA-1483196	0.321277	0.493	0	0
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	0.321277	0.493	0	0
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	0.321277	0.493	0	0
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	0.321277	0.493	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	0.321277	0.493	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	0.321277	0.493	0	0
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	0.321277	0.493	0	0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	0.321277	0.493	0	0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	0.321277	0.493	0	0
Defective HK1 causes hexokinase deficiency (HK deficiency)	R-HSA-5619056	0.321277	0.493	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	0.321277	0.493	0	0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	0.321277	0.493	0	0
Signaling by kinase domain mutants of KIT	R-HSA-9669933	0.321277	0.493	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	0.140926	0.851	0	0
Activation of AKT2	R-HSA-165158	0.229040	0.640	0	0
IRS activation	R-HSA-74713	0.229040	0.640	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	0.229040	0.640	0	0
G2 Phase	R-HSA-68911	0.229040	0.640	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	0.229040	0.640	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	0.229040	0.640	0	0
Type I hemidesmosome assembly	R-HSA-446107	0.171516	0.766	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	0.131697	0.880	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	0.155021	0.810	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	0.155021	0.810	0	0
Disorders of Nervous System Development	R-HSA-9697154	0.155021	0.810	0	0
Pervasive developmental disorders	R-HSA-9005895	0.155021	0.810	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	0.155021	0.810	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	0.203768	0.691	0	0
Calcineurin activates NFAT	R-HSA-2025928	0.203768	0.691	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	0.276510	0.558	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	0.276510	0.558	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	0.276510	0.558	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	0.276510	0.558	0	0
Signaling by MAPK mutants	R-HSA-9652817	0.276510	0.558	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	0.403537	0.394	0	0
Potassium transport channels	R-HSA-1296067	0.403537	0.394	0	0
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	0.403537	0.394	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	0.403537	0.394	0	0
Defective visual phototransduction due to STRA6 loss of function	R-HSA-9918449	0.403537	0.394	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	0.403537	0.394	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	0.403537	0.394	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	0.403537	0.394	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	0.403537	0.394	0	0
Disorders of Developmental Biology	R-HSA-9675151	0.138838	0.857	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	0.179751	0.745	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	0.237260	0.625	0	0
Folding of actin by CCT/TriC	R-HSA-390450	0.237260	0.625	0	0
Sema4D in semaphorin signaling	R-HSA-400685	0.110914	0.955	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	0.205684	0.687	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	0.205684	0.687	0	0
Regulation of KIT signaling	R-HSA-1433559	0.205684	0.687	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	0.323801	0.490	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	0.179744	0.745	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	0.111110	0.954	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	0.111110	0.954	0	0
Notch-HLH transcription pathway	R-HSA-350054	0.158024	0.801	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	0.271596	0.566	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	0.139574	0.855	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	0.139574	0.855	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	0.139574	0.855	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	0.232612	0.633	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	0.232612	0.633	0	0
HSF1 activation	R-HSA-3371511	0.110019	0.959	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	0.201702	0.695	0	0
HIV elongation arrest and recovery	R-HSA-167287	0.155123	0.809	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	0.155123	0.809	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	0.137073	0.863	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	0.195500	0.709	0	0
Co-inhibition by CTLA4	R-HSA-389513	0.224501	0.649	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	0.260329	0.584	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	0.306412	0.514	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	0.306412	0.514	0	0
MECP2 regulates transcription factors	R-HSA-9022707	0.370260	0.431	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	0.370260	0.431	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	0.370260	0.431	0	0
Disinhibition of SNARE formation	R-HSA-114516	0.370260	0.431	0	0
SOS-mediated signalling	R-HSA-112412	0.370260	0.431	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	0.370260	0.431	0	0
PLC-gamma1 signalling	R-HSA-167021	0.475832	0.323	0	0
Activated NTRK3 signals through PLCG1	R-HSA-9034793	0.475832	0.323	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	0.475832	0.323	0	0
The IPAF inflammasome	R-HSA-844623	0.475832	0.323	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	0.475832	0.323	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	0.475832	0.323	0	0
Defective GCLC causes HAGGSD	R-HSA-5578999	0.475832	0.323	0	0
Invadopodia formation	R-HSA-8941237	0.475832	0.323	0	0
MET activates PTPN11	R-HSA-8865999	0.475832	0.323	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	0.475832	0.323	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	0.165795	0.780	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	0.165795	0.780	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	0.165795	0.780	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	0.188440	0.725	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	0.248018	0.606	0	0
EGFR downregulation	R-HSA-182971	0.206104	0.686	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	0.117493	0.930	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	0.341378	0.467	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	0.341378	0.467	0	0
Leading Strand Synthesis	R-HSA-69109	0.341378	0.467	0	0
Polymerase switching	R-HSA-69091	0.341378	0.467	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	0.188263	0.725	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	0.159718	0.797	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	0.317330	0.498	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	0.415394	0.382	0	0
Formation of annular gap junctions	R-HSA-196025	0.415394	0.382	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	0.415394	0.382	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	0.415394	0.382	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	0.415394	0.382	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	0.171927	0.765	0	0
snRNP Assembly	R-HSA-191859	0.164358	0.784	0	0
Metabolism of non-coding RNA	R-HSA-194441	0.164358	0.784	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	0.376205	0.425	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	0.247834	0.606	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	0.346238	0.461	0	0
GAB1 signalosome	R-HSA-180292	0.346238	0.461	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	0.300554	0.522	0	0
Late endosomal microautophagy	R-HSA-9615710	0.300554	0.522	0	0
HIV Transcription Elongation	R-HSA-167169	0.265651	0.576	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	0.265651	0.576	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	0.265651	0.576	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	0.250811	0.601	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	0.267444	0.573	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	0.322828	0.491	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	0.346746	0.460	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	0.410636	0.387	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	0.410636	0.387	0	0
Removal of the Flap Intermediate	R-HSA-69166	0.410636	0.387	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	0.410636	0.387	0	0
ARMS-mediated activation	R-HSA-170984	0.458842	0.338	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	0.458842	0.338	0	0
Lipophagy	R-HSA-9613354	0.458842	0.338	0	0
Gap junction degradation	R-HSA-190873	0.458842	0.338	0	0
WNT mediated activation of DVL	R-HSA-201688	0.458842	0.338	0	0
ALK mutants bind TKIs	R-HSA-9700645	0.458842	0.338	0	0
MTF1 activates gene expression	R-HSA-5660489	0.539368	0.268	0	0
HCN channels	R-HSA-1296061	0.539368	0.268	0	0
Activated NTRK2 signals through PLCG1	R-HSA-9026527	0.539368	0.268	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	0.539368	0.268	0	0
betaKlotho-mediated ligand binding	R-HSA-1307965	0.539368	0.268	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	0.539368	0.268	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	0.539368	0.268	0	0
Signaling by MAP2K mutants	R-HSA-9652169	0.539368	0.268	0	0
RUNX2 regulates bone development	R-HSA-8941326	0.322413	0.492	0	0
AURKA Activation by TPX2	R-HSA-8854518	0.253917	0.595	0	0
Tight junction interactions	R-HSA-420029	0.371989	0.429	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	0.253791	0.596	0	0
Transcription of the HIV genome	R-HSA-167172	0.282278	0.549	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	0.444455	0.352	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	0.444455	0.352	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	0.444455	0.352	0	0
Centrosome maturation	R-HSA-380287	0.280842	0.552	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	0.314244	0.503	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	0.314244	0.503	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	0.500350	0.301	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	0.500350	0.301	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	0.500350	0.301	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	0.500350	0.301	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	0.500350	0.301	0	0
Phosphorylation of the APC/C	R-HSA-176412	0.477479	0.321	0	0
Meiotic synapsis	R-HSA-1221632	0.390574	0.408	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	0.447309	0.349	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	0.447309	0.349	0	0
Formation of the Early Elongation Complex	R-HSA-113418	0.447309	0.349	0	0
Neutrophil degranulation	R-HSA-6798695	0.157989	0.801	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	0.401056	0.397	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	0.410185	0.387	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	0.446508	0.350	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	0.446508	0.350	0	0
Signaling by Erythropoietin	R-HSA-9006335	0.471965	0.326	0	0
Signaling by KIT in disease	R-HSA-9669938	0.488445	0.311	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	0.488445	0.311	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	0.509555	0.293	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	0.509555	0.293	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	0.509555	0.293	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	0.509555	0.293	0	0
Phase 2 - plateau phase	R-HSA-5576893	0.509555	0.293	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	0.509555	0.293	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	0.539750	0.268	0	0
Signaling by APC mutants	R-HSA-4839744	0.539750	0.268	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	0.539750	0.268	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	0.539750	0.268	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	0.539750	0.268	0	0
Activation of AMPA receptors	R-HSA-399710	0.595206	0.225	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	0.595206	0.225	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	0.595206	0.225	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	0.595206	0.225	0	0
Defective F9 activation	R-HSA-9673221	0.595206	0.225	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	0.595206	0.225	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	0.595206	0.225	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	0.595206	0.225	0	0
COPI-mediated anterograde transport	R-HSA-6807878	0.410538	0.387	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	0.410538	0.387	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	0.480482	0.318	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	0.540564	0.267	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	0.540564	0.267	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	0.453317	0.344	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	0.541911	0.266	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	0.576943	0.239	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	0.576943	0.239	0	0
Nucleosome assembly	R-HSA-774815	0.527301	0.278	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	0.527301	0.278	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	0.570410	0.244	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	0.569441	0.245	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	0.588506	0.230	0	0
Regulation of signaling by CBL	R-HSA-912631	0.599024	0.223	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	0.599024	0.223	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	0.611885	0.213	0	0
IRAK1 recruits IKK complex	R-HSA-937039	0.611885	0.213	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	0.611885	0.213	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	0.611885	0.213	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	0.611885	0.213	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	0.611885	0.213	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	0.611885	0.213	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	0.611885	0.213	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	0.644278	0.191	0	0
Plus-strand DNA synthesis	R-HSA-164525	0.644278	0.191	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	0.644278	0.191	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	0.644278	0.191	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	0.644278	0.191	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	0.644278	0.191	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	0.644278	0.191	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	0.644278	0.191	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	0.644278	0.191	0	0
Cam-PDE 1 activation	R-HSA-111957	0.644278	0.191	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	0.616312	0.210	0	0
Cristae formation	R-HSA-8949613	0.616312	0.210	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	0.626357	0.203	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	0.626357	0.203	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	0.638574	0.195	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	0.639366	0.194	0	0
Signaling by ERBB2	R-HSA-1227986	0.108583	0.964	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	0.592359	0.227	0	0
RNA Polymerase III Transcription	R-HSA-74158	0.480482	0.318	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	0.432586	0.364	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	0.432586	0.364	0	0
Co-stimulation by CD28	R-HSA-389356	0.115539	0.937	0	0
EPH-Ephrin signaling	R-HSA-2682334	0.118720	0.925	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	0.317330	0.498	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	0.317330	0.498	0	0
Generation of second messenger molecules	R-HSA-202433	0.265651	0.576	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	0.266141	0.575	0	0
Signaling by SCF-KIT	R-HSA-1433557	0.218666	0.660	0	0
TCR signaling	R-HSA-202403	0.170440	0.768	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	0.401056	0.397	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	0.181112	0.742	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	0.272125	0.565	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	0.311544	0.506	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	0.384328	0.415	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	0.498191	0.303	0	0
Prolonged ERK activation events	R-HSA-169893	0.260329	0.584	0	0
GP1b-IX-V activation signalling	R-HSA-430116	0.203768	0.691	0	0
IRS-mediated signalling	R-HSA-112399	0.601187	0.221	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	0.188263	0.725	0	0
Signaling by FGFR4	R-HSA-5654743	0.487368	0.312	0	0
TGFBR3 expression	R-HSA-9839394	0.215380	0.667	0	0
DNA Double Strand Break Response	R-HSA-5693606	0.631406	0.200	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	0.283827	0.547	0	0
DNA strand elongation	R-HSA-69190	0.543482	0.265	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	0.551759	0.258	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	0.173800	0.760	0	0
Processive synthesis on the lagging strand	R-HSA-69183	0.444455	0.352	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	0.390574	0.408	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	0.509555	0.293	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	0.540564	0.267	0	0
Frs2-mediated activation	R-HSA-170968	0.376205	0.425	0	0
STING mediated induction of host immune responses	R-HSA-1834941	0.201702	0.695	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	0.469093	0.329	0	0
Regulation of TP53 Degradation	R-HSA-6804757	0.110019	0.959	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	0.215380	0.667	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	0.317330	0.498	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	0.500350	0.301	0	0
PI3K Cascade	R-HSA-109704	0.474286	0.324	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	0.107395	0.969	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	0.523955	0.281	0	0
IGF1R signaling cascade	R-HSA-2428924	0.452159	0.345	0	0
Germ layer formation at gastrulation	R-HSA-9754189	0.599024	0.223	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	0.276510	0.558	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	0.276510	0.558	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	0.123733	0.908	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	0.370260	0.431	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	0.317330	0.498	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	0.458842	0.338	0	0
PI3K/AKT activation	R-HSA-198203	0.500350	0.301	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	0.477479	0.321	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	0.488445	0.311	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	0.540564	0.267	0	0
Terminal pathway of complement	R-HSA-166665	0.644278	0.191	0	0
Oncogene Induced Senescence	R-HSA-2559585	0.181112	0.742	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	0.346238	0.461	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	0.151104	0.821	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	0.165795	0.780	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	0.188263	0.725	1	1
Hedgehog 'off' state	R-HSA-5610787	0.364172	0.439	0	0
Signalling to ERKs	R-HSA-187687	0.458293	0.339	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	0.201702	0.695	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	0.541604	0.266	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	0.586778	0.232	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	0.143268	0.844	0	0
HIV Life Cycle	R-HSA-162587	0.201674	0.695	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	0.117381	0.930	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	0.458314	0.339	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	0.112438	0.949	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	0.179744	0.745	0	0
mTORC1-mediated signalling	R-HSA-166208	0.296697	0.528	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	0.321611	0.493	0	0
Unwinding of DNA	R-HSA-176974	0.458842	0.338	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	0.216999	0.664	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	0.322413	0.492	0	0
Meiosis	R-HSA-1500620	0.319500	0.496	0	0
Budding and maturation of HIV virion	R-HSA-162588	0.520118	0.284	0	0
NF-kB is activated and signals survival	R-HSA-209560	0.576943	0.239	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	0.599024	0.223	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	0.611885	0.213	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	0.611885	0.213	0	0
Signaling by MST1	R-HSA-8852405	0.644278	0.191	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	0.639366	0.194	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	0.556505	0.255	0	0
G-protein beta:gamma signalling	R-HSA-397795	0.243159	0.614	0	0
Nuclear RNA decay	R-HSA-9930044	0.566293	0.247	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	0.160513	0.794	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	0.299590	0.523	0	0
UCH proteinases	R-HSA-5689603	0.522375	0.282	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	0.570410	0.244	0	0
Developmental Cell Lineages	R-HSA-9734767	0.625099	0.204	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	0.146508	0.834	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	0.181112	0.742	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	0.616312	0.210	0	0
S Phase	R-HSA-69242	0.480776	0.318	0	0
Integrin signaling	R-HSA-354192	0.390639	0.408	0	0
PIP3 activates AKT signaling	R-HSA-1257604	0.219834	0.658	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	0.133731	0.874	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	0.230424	0.637	0	0
p75NTR signals via NF-kB	R-HSA-193639	0.444455	0.352	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	0.567543	0.246	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	0.610325	0.214	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	0.622063	0.206	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	0.188263	0.725	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	0.341520	0.467	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	0.583437	0.234	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	0.610325	0.214	0	0
HIV Infection	R-HSA-162906	0.255102	0.593	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	0.108606	0.964	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	0.151104	0.821	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	0.151104	0.821	0	0
Adrenoceptors	R-HSA-390696	0.415394	0.382	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	0.243159	0.614	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	0.322828	0.491	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	0.410636	0.387	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	0.238284	0.623	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	0.432586	0.364	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	0.500350	0.301	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	0.471965	0.326	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	0.509555	0.293	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	0.595206	0.225	0	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	0.595206	0.225	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	0.576943	0.239	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	0.527301	0.278	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	0.567543	0.246	0	0
Aggrephagy	R-HSA-9646399	0.565892	0.247	0	0
p75NTR recruits signalling complexes	R-HSA-209543	0.611885	0.213	0	0
Cilium Assembly	R-HSA-5617833	0.243239	0.614	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	0.551759	0.258	0	0
Ub-specific processing proteases	R-HSA-5689880	0.170069	0.769	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	0.565984	0.247	0	0
Mitotic Prophase	R-HSA-68875	0.155505	0.808	0	0
TBC/RABGAPs	R-HSA-8854214	0.129919	0.886	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	0.413306	0.384	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	0.471965	0.326	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	0.553306	0.257	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	0.639366	0.194	0	0
Signaling by ROBO receptors	R-HSA-376176	0.231421	0.636	0	0
Autophagy	R-HSA-9612973	0.253989	0.595	0	0
Gene expression (Transcription)	R-HSA-74160	0.641399	0.193	1	0
RNA Polymerase II Transcription	R-HSA-73857	0.636427	0.196	1	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	0.131697	0.880	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	0.260329	0.584	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	0.371989	0.429	0	0
Platelet calcium homeostasis	R-HSA-418360	0.471965	0.326	0	0
Acyl chain remodelling of PS	R-HSA-1482801	0.567543	0.246	0	0
PTEN Regulation	R-HSA-6807070	0.632035	0.199	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	0.455000	0.342	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	0.350164	0.456	0	0
Integration of energy metabolism	R-HSA-163685	0.142793	0.845	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	0.397230	0.401	0	0
Mitophagy	R-HSA-5205647	0.610081	0.215	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	0.586178	0.232	0	0
Signaling by FGFR in disease	R-HSA-1226099	0.372006	0.429	0	0
Glycogen metabolism	R-HSA-8982491	0.405103	0.392	0	0
TNF signaling	R-HSA-75893	0.211083	0.676	0	0
DNA Repair	R-HSA-73894	0.581956	0.235	0	0
Nef and signal transduction	R-HSA-164944	0.112438	0.949	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	0.158024	0.801	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	0.166645	0.778	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	0.539368	0.268	0	0
Cellular Senescence	R-HSA-2559583	0.126650	0.897	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	0.397230	0.401	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	0.329094	0.483	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	0.539750	0.268	0	0
Activation of C3 and C5	R-HSA-174577	0.595206	0.225	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	0.588506	0.230	0	0
Vesicle-mediated transport	R-HSA-5653656	0.291761	0.535	0	0
Macroautophagy	R-HSA-1632852	0.390926	0.408	0	0
Neurodegenerative Diseases	R-HSA-8863678	0.195500	0.709	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	0.195500	0.709	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	0.188440	0.725	0	0
Glycogen synthesis	R-HSA-3322077	0.626357	0.203	0	0
Selective autophagy	R-HSA-9663891	0.375205	0.426	0	0
Ion homeostasis	R-HSA-5578775	0.211083	0.676	1	1
RAF-independent MAPK1/3 activation	R-HSA-112409	0.488445	0.311	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	0.520118	0.284	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	0.173375	0.761	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	0.592359	0.227	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	0.274872	0.561	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	0.112438	0.949	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	0.229040	0.640	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	0.323801	0.490	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	0.502971	0.298	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	0.225807	0.646	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	0.159873	0.796	0	0
Smooth Muscle Contraction	R-HSA-445355	0.268254	0.571	0	0
Signaling by FGFR1	R-HSA-5654736	0.583957	0.234	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	0.390639	0.408	0	0
Deubiquitination	R-HSA-5688426	0.155697	0.808	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	0.509555	0.293	0	0
Signaling by Hedgehog	R-HSA-5358351	0.532056	0.274	0	0
Spry regulation of FGF signaling	R-HSA-1295596	0.444455	0.352	0	0
Mitotic G2-G2/M phases	R-HSA-453274	0.175554	0.756	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	0.257008	0.590	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	0.158024	0.801	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	0.611935	0.213	0	0
G2/M Transition	R-HSA-69275	0.270448	0.568	0	0
MAP kinase activation	R-HSA-450294	0.401056	0.397	0	0
HDMs demethylate histones	R-HSA-3214842	0.110914	0.955	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	0.435154	0.361	0	0
Heme signaling	R-HSA-9707616	0.418110	0.379	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	0.123733	0.908	0	0
Cardiac conduction	R-HSA-5576891	0.351364	0.454	1	0
Transmission across Chemical Synapses	R-HSA-112315	0.172516	0.763	1	0
Regulation of TNFR1 signaling	R-HSA-5357905	0.267444	0.573	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	0.425848	0.371	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	0.182240	0.739	0	0
Manipulation of host energy metabolism	R-HSA-9636667	0.321277	0.493	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	0.321277	0.493	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	0.120112	0.920	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	0.276510	0.558	0	0
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	0.403537	0.394	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	0.179751	0.745	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	0.179744	0.745	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	0.475832	0.323	0	0
MET interacts with TNS proteins	R-HSA-8875513	0.475832	0.323	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	0.248018	0.606	0	0
Recycling pathway of L1	R-HSA-437239	0.179894	0.745	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	0.213470	0.671	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	0.415394	0.382	0	0
Co-stimulation by ICOS	R-HSA-9927354	0.415394	0.382	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	0.376205	0.425	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	0.458842	0.338	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	0.539368	0.268	0	0
Transmission across Electrical Synapses	R-HSA-112307	0.539368	0.268	0	0
Electric Transmission Across Gap Junctions	R-HSA-112303	0.539368	0.268	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	0.339995	0.469	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	0.378304	0.422	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	0.477479	0.321	0	0
Host Interactions of HIV factors	R-HSA-162909	0.333223	0.477	0	0
GPER1 signaling	R-HSA-9634597	0.436085	0.360	0	0
Bicarbonate transporters	R-HSA-425381	0.539750	0.268	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	0.539750	0.268	0	0
Suppression of autophagy	R-HSA-9636569	0.595206	0.225	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	0.390461	0.408	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	0.576943	0.239	0	0
Signaling by AXIN mutants	R-HSA-4839735	0.576943	0.239	0	0
Signaling by AMER1 mutants	R-HSA-4839748	0.576943	0.239	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	0.533041	0.273	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	0.566984	0.246	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	0.584160	0.233	0	0
Pentose phosphate pathway disease	R-HSA-6791465	0.644278	0.191	0	0
PKB-mediated events	R-HSA-109703	0.644278	0.191	0	0
PDE3B signalling	R-HSA-165160	0.644278	0.191	0	0
Synthesis of PS	R-HSA-1483101	0.644278	0.191	0	0
Phosphorylation of Emi1	R-HSA-176417	0.644278	0.191	0	0
Degradation of CDH1	R-HSA-9766229	0.603146	0.220	0	0
Negative regulation of MET activity	R-HSA-6807004	0.626357	0.203	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	0.211083	0.676	0	0
Interleukin-17 signaling	R-HSA-448424	0.551759	0.258	0	0
Cellular responses to stimuli	R-HSA-8953897	0.431877	0.365	1	0
Regulation of insulin secretion	R-HSA-422356	0.177785	0.750	0	0
Signaling by TGFB family members	R-HSA-9006936	0.290940	0.536	0	0
Cellular responses to stress	R-HSA-2262752	0.625195	0.204	1	0
Mismatch Repair	R-HSA-5358508	0.570410	0.244	0	0
Cell junction organization	R-HSA-446728	0.128409	0.891	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	0.170069	0.769	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	0.170069	0.769	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	0.603146	0.220	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	0.603146	0.220	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	0.360262	0.443	0	0
Chromatin modifying enzymes	R-HSA-3247509	0.121260	0.916	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	0.621792	0.206	0	0
Programmed Cell Death	R-HSA-5357801	0.116702	0.933	0	0
Chromatin organization	R-HSA-4839726	0.125459	0.901	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	0.550139	0.260	0	0
Signaling by NOTCH3	R-HSA-9012852	0.426692	0.370	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	0.442566	0.354	0	0
PECAM1 interactions	R-HSA-210990	0.271596	0.566	0	0
Suppression of apoptosis	R-HSA-9635465	0.271596	0.566	0	0
Kinesins	R-HSA-983189	0.268367	0.571	0	0
ERK/MAPK targets	R-HSA-198753	0.432586	0.364	0	0
Signal attenuation	R-HSA-74749	0.500350	0.301	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	0.471965	0.326	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	0.413316	0.384	0	0
Cell-cell junction organization	R-HSA-421270	0.523369	0.281	0	0
Regulation of TP53 Activity	R-HSA-5633007	0.226098	0.646	0	0
Activation of BH3-only proteins	R-HSA-114452	0.322828	0.491	0	0
Adherens junctions interactions	R-HSA-418990	0.578282	0.238	0	0
Negative regulation of FLT3	R-HSA-9706369	0.477479	0.321	0	0
Interleukin-1 family signaling	R-HSA-446652	0.610585	0.214	0	0
FLT3 signaling in disease	R-HSA-9682385	0.480482	0.318	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	0.229040	0.640	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	0.232612	0.633	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	0.151104	0.821	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	0.272125	0.565	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	0.410636	0.387	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	0.539368	0.268	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	0.444455	0.352	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	0.477479	0.321	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	0.595206	0.225	0	0
HATs acetylate histones	R-HSA-3214847	0.451729	0.345	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	0.576943	0.239	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	0.567543	0.246	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	0.567543	0.246	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	0.644278	0.191	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	0.644278	0.191	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	0.422368	0.374	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	0.566293	0.247	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	0.526451	0.279	0	0
Reproduction	R-HSA-1474165	0.517944	0.286	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	0.390574	0.408	0	0
Interleukin-6 family signaling	R-HSA-6783589	0.346746	0.460	0	0
Downstream signal transduction	R-HSA-186763	0.345322	0.462	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	0.151104	0.821	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	0.599024	0.223	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	0.562258	0.250	1	0
Aquaporin-mediated transport	R-HSA-445717	0.283428	0.548	0	0
Integration of provirus	R-HSA-162592	0.576943	0.239	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	0.260329	0.584	0	0
Other interleukin signaling	R-HSA-449836	0.375186	0.426	0	0
Ion transport by P-type ATPases	R-HSA-936837	0.583553	0.234	1	1
Interleukin-6 signaling	R-HSA-1059683	0.376205	0.425	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	0.515521	0.288	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	0.583957	0.234	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	0.160866	0.794	0	0
Signaling by TGFBR3	R-HSA-9839373	0.546817	0.262	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	0.625219	0.204	0	0
Breakdown of the nuclear lamina	R-HSA-352238	0.321277	0.493	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	0.276510	0.558	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	0.205684	0.687	0	0
Synthesis of PI	R-HSA-1483226	0.271596	0.566	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	0.475832	0.323	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	0.243159	0.614	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	0.458842	0.338	0	0
NADE modulates death signalling	R-HSA-205025	0.539368	0.268	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	0.539368	0.268	0	0
Other semaphorin interactions	R-HSA-416700	0.444455	0.352	0	0
Protein methylation	R-HSA-8876725	0.444455	0.352	0	0
Tandem pore domain potassium channels	R-HSA-1296346	0.500350	0.301	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	0.477479	0.321	0	0
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	0.595206	0.225	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	0.541911	0.266	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	0.592359	0.227	0	0
The NLRP3 inflammasome	R-HSA-844456	0.599024	0.223	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	0.644278	0.191	0	0
Intestinal hexose absorption	R-HSA-8981373	0.644278	0.191	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	0.303828	0.517	0	0
Diseases of DNA repair	R-HSA-9675135	0.267444	0.573	0	0
Signaling by Interleukins	R-HSA-449147	0.246317	0.609	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	0.193036	0.714	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	0.496259	0.304	0	0
Ion channel transport	R-HSA-983712	0.593195	0.227	1	0
L1CAM interactions	R-HSA-373760	0.126262	0.899	0	0
G2/M Checkpoints	R-HSA-69481	0.379394	0.421	0	0
Nuclear import of Rev protein	R-HSA-180746	0.165795	0.780	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	0.500350	0.301	0	0
tRNA processing in the nucleus	R-HSA-6784531	0.550139	0.260	0	0
Inflammasomes	R-HSA-622312	0.639366	0.194	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	0.436085	0.360	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	0.175233	0.756	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	0.372552	0.429	0	0
Syndecan interactions	R-HSA-3000170	0.515521	0.288	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	0.142164	0.847	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	0.390639	0.408	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	0.276510	0.558	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	0.370260	0.431	0	0
Regulation of PTEN localization	R-HSA-8948747	0.370260	0.431	0	0
Signaling by PDGFR in disease	R-HSA-9671555	0.272125	0.565	0	0
Interleukin-18 signaling	R-HSA-9012546	0.415394	0.382	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	0.265651	0.576	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	0.283827	0.547	0	0
Dopamine receptors	R-HSA-390651	0.539368	0.268	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	0.539368	0.268	0	0
G2/M DNA damage checkpoint	R-HSA-69473	0.267199	0.573	0	0
Stimuli-sensing channels	R-HSA-2672351	0.483201	0.316	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	0.592359	0.227	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	0.644278	0.191	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	0.644278	0.191	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	0.644278	0.191	0	0
Inositol phosphate metabolism	R-HSA-1483249	0.435719	0.361	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	0.523955	0.281	0	0
Nephron development	R-HSA-9831926	0.346238	0.461	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	0.432586	0.364	0	0
Regulation of beta-cell development	R-HSA-186712	0.253576	0.596	0	0
Interleukin-7 signaling	R-HSA-1266695	0.567543	0.246	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	0.458842	0.338	0	0
Specification of primordial germ cells	R-HSA-9827857	0.317330	0.498	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	0.415394	0.382	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	0.458842	0.338	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	0.444455	0.352	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	0.595206	0.225	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	0.595206	0.225	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	0.644278	0.191	0	0
Assembly Of The HIV Virion	R-HSA-175474	0.460767	0.337	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	0.511849	0.291	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	0.435880	0.361	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	0.247834	0.606	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	0.540564	0.267	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	0.460767	0.337	0	0
OAS antiviral response	R-HSA-8983711	0.611885	0.213	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	0.458842	0.338	0	0
HDL assembly	R-HSA-8963896	0.410636	0.387	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	0.432586	0.364	0	0
Signaling by Leptin	R-HSA-2586552	0.500350	0.301	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	0.488445	0.311	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	0.644575	0.191	0	0
Adenylate cyclase activating pathway	R-HSA-170660	0.644575	0.191	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	0.644575	0.191	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	0.644575	0.191	0	0
Processing of SMDT1	R-HSA-8949664	0.644575	0.191	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	0.644575	0.191	0	0
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	0.644575	0.191	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	0.644575	0.191	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	0.644575	0.191	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	0.644575	0.191	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	0.646681	0.189	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	0.648202	0.188	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	0.649208	0.188	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	0.649995	0.187	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	0.649995	0.187	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	0.649995	0.187	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	0.650603	0.187	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	0.651191	0.186	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	0.652378	0.186	0	0
Lagging Strand Synthesis	R-HSA-69186	0.652378	0.186	0	0
Basigin interactions	R-HSA-210991	0.652378	0.186	0	0
Signaling by NTRKs	R-HSA-166520	0.652428	0.185	0	0
Platelet degranulation	R-HSA-114608	0.655461	0.183	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	0.661495	0.179	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	0.666370	0.176	0	0
Degradation of DVL	R-HSA-4641258	0.670679	0.173	0	0
Ovarian tumor domain proteases	R-HSA-5689896	0.670679	0.173	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	0.672108	0.173	0	0
CRMPs in Sema3A signaling	R-HSA-399956	0.675046	0.171	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	0.675046	0.171	0	0
cGMP effects	R-HSA-418457	0.675046	0.171	0	0
Physiological factors	R-HSA-5578768	0.675046	0.171	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	0.675046	0.171	0	0
Zinc transporters	R-HSA-435354	0.675046	0.171	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	0.676136	0.170	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	0.677076	0.169	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	0.677076	0.169	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	0.678748	0.168	0	0
Fanconi Anemia Pathway	R-HSA-6783310	0.679589	0.168	0	0
Signaling by FGFR3	R-HSA-5654741	0.679589	0.168	0	0
Mitochondrial protein import	R-HSA-1268020	0.681491	0.167	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	0.682682	0.166	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	0.682682	0.166	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	0.682682	0.166	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	0.682682	0.166	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	0.683770	0.165	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	0.685344	0.164	0	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	0.687403	0.163	0	0
STAT5 Activation	R-HSA-9645135	0.687403	0.163	0	0
Erythropoietin activates STAT5	R-HSA-9027283	0.687403	0.163	0	0
Uncoating of the HIV Virion	R-HSA-162585	0.687403	0.163	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	0.687403	0.163	0	0
Defective CYP11A1 causes AICSR	R-HSA-5579026	0.687403	0.163	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	0.687403	0.163	0	0
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	0.687403	0.163	0	0
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	0.687403	0.163	0	0
Agmatine biosynthesis	R-HSA-351143	0.687403	0.163	0	0
Leukotriene receptors	R-HSA-391906	0.687403	0.163	0	0
Lipid particle organization	R-HSA-8964572	0.687403	0.163	0	0
Neurofascin interactions	R-HSA-447043	0.687403	0.163	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	0.690295	0.161	0	0
Hedgehog 'on' state	R-HSA-5632684	0.690295	0.161	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	0.695152	0.158	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	0.696282	0.157	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	0.698594	0.156	0	0
FGFR2 alternative splicing	R-HSA-6803529	0.700449	0.155	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	0.700449	0.155	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	0.700449	0.155	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	0.703355	0.153	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	0.703355	0.153	0	0
Translesion synthesis by REV1	R-HSA-110312	0.703355	0.153	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	0.703355	0.153	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	0.703355	0.153	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	0.703355	0.153	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	0.703355	0.153	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	0.703355	0.153	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	0.703355	0.153	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	0.703355	0.153	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	0.703355	0.153	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	0.704062	0.152	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	0.706450	0.151	0	0
Stabilization of p53	R-HSA-69541	0.707450	0.150	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	0.707450	0.150	0	0
Insulin receptor signalling cascade	R-HSA-74751	0.710627	0.148	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	0.712856	0.147	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	0.714427	0.146	0	0
Circadian clock	R-HSA-9909396	0.718006	0.144	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	0.718627	0.143	0	0
G1/S Transition	R-HSA-69206	0.720913	0.142	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	0.722511	0.141	0	0
Interleukin receptor SHC signaling	R-HSA-912526	0.722511	0.141	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	0.722511	0.141	0	0
Growth hormone receptor signaling	R-HSA-982772	0.722511	0.141	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	0.724719	0.140	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	0.724719	0.140	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	0.724719	0.140	0	0
Interleukin-2 family signaling	R-HSA-451927	0.724719	0.140	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	0.725303	0.139	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	0.725303	0.139	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	0.725303	0.139	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	0.725303	0.139	0	0
Recycling of eIF2:GDP	R-HSA-72731	0.725303	0.139	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	0.725303	0.139	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	0.725303	0.139	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	0.725303	0.139	0	0
PTK6 Expression	R-HSA-8849473	0.725303	0.139	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	0.725303	0.139	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	0.725303	0.139	0	0
Electron transport from NADPH to Ferredoxin	R-HSA-2395516	0.725303	0.139	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	0.725303	0.139	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	0.725303	0.139	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	0.725303	0.139	0	0
Ca2+ activated K+ channels	R-HSA-1296052	0.725303	0.139	0	0
VLDL clearance	R-HSA-8964046	0.725303	0.139	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	0.725303	0.139	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	0.725303	0.139	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	0.725303	0.139	0	0
Glycoprotein hormones	R-HSA-209822	0.725303	0.139	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	0.725303	0.139	0	0
CHL1 interactions	R-HSA-447041	0.725303	0.139	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	0.725303	0.139	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	0.725303	0.139	0	0
Translesion synthesis by POLI	R-HSA-5656121	0.729579	0.137	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	0.729579	0.137	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	0.729579	0.137	0	0
Killing mechanisms	R-HSA-9664420	0.729579	0.137	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	0.729579	0.137	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	0.729579	0.137	0	0
Differentiation of T cells	R-HSA-9945266	0.729579	0.137	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	0.729579	0.137	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	0.729579	0.137	0	0
Signaling by NOTCH4	R-HSA-9013694	0.730403	0.136	0	0
Downstream TCR signaling	R-HSA-202424	0.730415	0.136	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	0.736583	0.133	0	0
Generic Transcription Pathway	R-HSA-212436	0.737402	0.132	1	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	0.737956	0.132	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	0.738184	0.132	0	0
Regulation of necroptotic cell death	R-HSA-5675482	0.740550	0.130	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	0.740550	0.130	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	0.740550	0.130	0	0
Activation of ATR in response to replication stress	R-HSA-176187	0.740550	0.130	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	0.740550	0.130	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	0.743284	0.129	0	0
TNFs bind their physiological receptors	R-HSA-5669034	0.743284	0.129	0	0
Plasma lipoprotein assembly	R-HSA-8963898	0.743284	0.129	0	0
DNA Damage Bypass	R-HSA-73893	0.743670	0.129	0	0
Signaling by FGFR	R-HSA-190236	0.747465	0.126	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	0.752884	0.123	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	0.753807	0.123	0	0
Translesion synthesis by POLK	R-HSA-5655862	0.753807	0.123	0	0
Synthesis of PG	R-HSA-1483148	0.753807	0.123	0	0
Chromosome Maintenance	R-HSA-73886	0.753867	0.123	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	0.757027	0.121	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	0.757027	0.121	0	0
HIV Transcription Initiation	R-HSA-167161	0.757027	0.121	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	0.757027	0.121	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	0.757027	0.121	0	0
Intra-Golgi traffic	R-HSA-6811438	0.757027	0.121	0	0
Reverse Transcription of HIV RNA	R-HSA-162589	0.758609	0.120	0	0
Minus-strand DNA synthesis	R-HSA-164516	0.758609	0.120	0	0
phospho-PLA2 pathway	R-HSA-111995	0.758609	0.120	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	0.758609	0.120	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	0.758609	0.120	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	0.758609	0.120	0	0
MET receptor recycling	R-HSA-8875656	0.758609	0.120	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	0.758609	0.120	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	0.758609	0.120	0	0
Sodium/Proton exchangers	R-HSA-425986	0.758609	0.120	0	0
Interleukin-9 signaling	R-HSA-8985947	0.758609	0.120	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	0.758609	0.120	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	0.758609	0.120	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	0.758609	0.120	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	0.758609	0.120	0	0
Alpha-defensins	R-HSA-1462054	0.758609	0.120	0	0
Intestinal absorption	R-HSA-8963676	0.758609	0.120	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	0.763455	0.117	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	0.767750	0.115	0	0
Meiotic recombination	R-HSA-912446	0.772030	0.112	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	0.772453	0.112	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	0.772722	0.112	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	0.773353	0.112	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	0.774446	0.111	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	0.774446	0.111	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	0.776137	0.110	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	0.776137	0.110	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	0.776137	0.110	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	0.776137	0.110	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	0.778283	0.109	0	0
Myogenesis	R-HSA-525793	0.781088	0.107	0	0
Metalloprotease DUBs	R-HSA-5689901	0.781088	0.107	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	0.781088	0.107	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	0.782389	0.107	0	0
Mitochondrial protein degradation	R-HSA-9837999	0.784540	0.105	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	0.785301	0.105	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	0.785301	0.105	0	0
Eukaryotic Translation Initiation	R-HSA-72613	0.786149	0.104	0	0
Cap-dependent Translation Initiation	R-HSA-72737	0.786149	0.104	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	0.786402	0.104	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	0.786402	0.104	0	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	0.787879	0.104	0	0
MAPK1 (ERK2) activation	R-HSA-112411	0.787879	0.104	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	0.787879	0.104	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	0.787879	0.104	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	0.787879	0.104	0	0
Interleukin-21 signaling	R-HSA-9020958	0.787879	0.104	0	0
p75NTR regulates axonogenesis	R-HSA-193697	0.787879	0.104	0	0
Degradation of GABA	R-HSA-916853	0.787879	0.104	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	0.787879	0.104	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	0.787879	0.104	0	0
Interleukin-1 processing	R-HSA-448706	0.787879	0.104	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	0.787879	0.104	0	0
ESR-mediated signaling	R-HSA-8939211	0.791857	0.101	0	0
Mitochondrial biogenesis	R-HSA-1592230	0.794955	0.100	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	0.796674	0.099	0	0
Apoptotic factor-mediated response	R-HSA-111471	0.796674	0.099	0	0
Platelet sensitization by LDL	R-HSA-432142	0.796674	0.099	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	0.796674	0.099	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	0.796674	0.099	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	0.797595	0.098	0	0
Signaling by PDGF	R-HSA-186797	0.797595	0.098	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	0.797977	0.098	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	0.798198	0.098	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	0.798198	0.098	0	0
Insulin processing	R-HSA-264876	0.798198	0.098	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	0.798289	0.098	0	0
Regulation of mitotic cell cycle	R-HSA-453276	0.798289	0.098	0	0
Signaling by FGFR2	R-HSA-5654738	0.799704	0.097	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	0.800018	0.097	0	0
Proteasome assembly	R-HSA-9907900	0.800018	0.097	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	0.801500	0.096	0	0
Diseases of programmed cell death	R-HSA-9645723	0.801614	0.096	0	0
G1/S-Specific Transcription	R-HSA-69205	0.804750	0.094	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	0.804750	0.094	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	0.809003	0.092	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	0.809015	0.092	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	0.809015	0.092	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	0.809847	0.092	0	0
Translation initiation complex formation	R-HSA-72649	0.810066	0.091	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	0.810066	0.091	0	0
Signaling by NOTCH	R-HSA-157118	0.810278	0.091	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	0.811785	0.091	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	0.811785	0.091	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	0.812940	0.090	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	0.812940	0.090	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	0.813038	0.090	0	0
Binding and entry of HIV virion	R-HSA-173107	0.813601	0.090	0	0
2-LTR circle formation	R-HSA-164843	0.813601	0.090	0	0
DNA replication initiation	R-HSA-68952	0.813601	0.090	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	0.813601	0.090	0	0
Regulation of CDH11 function	R-HSA-9762292	0.813601	0.090	0	0
Metabolism of serotonin	R-HSA-380612	0.813601	0.090	0	0
CASP4 inflammasome assembly	R-HSA-9948001	0.813601	0.090	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	0.813601	0.090	0	0
Pexophagy	R-HSA-9664873	0.813601	0.090	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	0.813601	0.090	0	0
Interleukin-27 signaling	R-HSA-9020956	0.813601	0.090	0	0
Maturation of spike protein	R-HSA-9683686	0.813601	0.090	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	0.813601	0.090	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	0.813601	0.090	0	0
Sperm Motility And Taxes	R-HSA-1300642	0.813601	0.090	0	0
Peptide hormone biosynthesis	R-HSA-209952	0.813601	0.090	0	0
Regulation of the apoptosome activity	R-HSA-9627069	0.813601	0.090	0	0
Formation of apoptosome	R-HSA-111458	0.813601	0.090	0	0
Pyroptosis	R-HSA-5620971	0.814174	0.089	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	0.814174	0.089	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	0.815523	0.089	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	0.815523	0.089	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	0.815523	0.089	0	0
Specification of the neural plate border	R-HSA-9834899	0.815523	0.089	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	0.815523	0.089	0	0
Maturation of nucleoprotein	R-HSA-9694631	0.815523	0.089	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	0.815523	0.089	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	0.818614	0.087	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	0.818614	0.087	0	0
NCAM1 interactions	R-HSA-419037	0.818614	0.087	0	0
Switching of origins to a post-replicative state	R-HSA-69052	0.819279	0.087	0	0
Ca2+ pathway	R-HSA-4086398	0.819279	0.087	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	0.819815	0.086	0	0
Neurotransmitter release cycle	R-HSA-112310	0.820523	0.086	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	0.821582	0.085	0	0
G alpha (z) signalling events	R-HSA-418597	0.821582	0.085	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	0.825185	0.083	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	0.829064	0.081	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	0.829064	0.081	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	0.829064	0.081	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	0.829064	0.081	0	0
MET promotes cell motility	R-HSA-8875878	0.831657	0.080	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	0.831657	0.080	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	0.831657	0.080	0	0
Estrogen-dependent gene expression	R-HSA-9018519	0.832112	0.080	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	0.832536	0.080	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	0.832792	0.079	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	0.832792	0.079	0	0
Formation of definitive endoderm	R-HSA-9823730	0.832792	0.079	0	0
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	0.832792	0.079	0	0
Signal transduction by L1	R-HSA-445144	0.832792	0.079	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	0.835102	0.078	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	0.835102	0.078	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	0.836206	0.078	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	0.836206	0.078	0	0
vRNA Synthesis	R-HSA-192814	0.836206	0.078	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	0.836206	0.078	0	0
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	0.836206	0.078	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	0.836206	0.078	0	0
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	0.836206	0.078	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	0.836206	0.078	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	0.836206	0.078	0	0
Transport of RCbl within the body	R-HSA-9758890	0.836206	0.078	0	0
Interleukin-2 signaling	R-HSA-9020558	0.836206	0.078	0	0
Dissolution of Fibrin Clot	R-HSA-75205	0.836206	0.078	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	0.836772	0.077	0	0
FOXO-mediated transcription	R-HSA-9614085	0.838631	0.076	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	0.841802	0.075	0	0
Activation of the pre-replicative complex	R-HSA-68962	0.842917	0.074	0	0
DAP12 signaling	R-HSA-2424491	0.842917	0.074	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	0.842917	0.074	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	0.846717	0.072	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	0.847199	0.072	0	0
Gluconeogenesis	R-HSA-70263	0.847722	0.072	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	0.848588	0.071	0	0
Signalling to RAS	R-HSA-167044	0.848588	0.071	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	0.848588	0.071	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	0.848672	0.071	0	0
Epigenetic regulation of gene expression	R-HSA-212165	0.849918	0.071	0	0
Signaling by WNT	R-HSA-195721	0.850663	0.070	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	0.852821	0.069	0	0
Interleukin-1 signaling	R-HSA-9020702	0.854136	0.068	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	0.855787	0.068	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	0.855787	0.068	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	0.855787	0.068	0	0
Cargo concentration in the ER	R-HSA-5694530	0.855787	0.068	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	0.855787	0.068	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	0.856070	0.067	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	0.856070	0.067	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	0.856070	0.067	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	0.856070	0.067	0	0
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	0.856070	0.067	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	0.856070	0.067	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	0.856070	0.067	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	0.858057	0.066	0	0
Regulated Necrosis	R-HSA-5218859	0.858489	0.066	0	0
Extension of Telomeres	R-HSA-180786	0.862183	0.064	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	0.863012	0.064	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	0.863012	0.064	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	0.863012	0.064	0	0
Glutathione synthesis and recycling	R-HSA-174403	0.863012	0.064	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	0.863012	0.064	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	0.863012	0.064	0	0
PCP/CE pathway	R-HSA-4086400	0.864359	0.063	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	0.864767	0.063	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	0.866163	0.062	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	0.867724	0.062	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	0.867724	0.062	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	0.867798	0.062	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	0.873527	0.059	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	0.873527	0.059	0	0
GRB2 events in EGFR signaling	R-HSA-179812	0.873527	0.059	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	0.873527	0.059	0	0
Regulation of IFNG signaling	R-HSA-877312	0.873527	0.059	0	0
Interleukin-35 Signalling	R-HSA-8984722	0.873527	0.059	0	0
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	0.873527	0.059	0	0
Signaling by LTK	R-HSA-9842663	0.873527	0.059	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	0.873527	0.059	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	0.873527	0.059	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	0.873527	0.059	0	0
Synthesis of GDP-mannose	R-HSA-446205	0.873527	0.059	0	0
Estrogen biosynthesis	R-HSA-193144	0.873527	0.059	0	0
Interleukin-15 signaling	R-HSA-8983432	0.873527	0.059	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	0.873527	0.059	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	0.876006	0.057	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	0.876167	0.057	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	0.876167	0.057	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	0.876167	0.057	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	0.876167	0.057	0	0
Ethanol oxidation	R-HSA-71384	0.876167	0.057	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	0.876167	0.057	0	0
Cellular hexose transport	R-HSA-189200	0.876167	0.057	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	0.876167	0.057	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	0.876230	0.057	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	0.876968	0.057	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	0.876968	0.057	0	0
Cardiogenesis	R-HSA-9733709	0.878780	0.056	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	0.882572	0.054	0	0
Orc1 removal from chromatin	R-HSA-68949	0.885592	0.053	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	0.885592	0.053	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	0.885635	0.053	0	0
Leishmania infection	R-HSA-9658195	0.886497	0.052	0	0
Parasitic Infection Pathways	R-HSA-9824443	0.886497	0.052	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	0.886755	0.052	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	0.887348	0.052	0	0
Nucleotide Excision Repair	R-HSA-5696398	0.887783	0.052	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	0.888146	0.052	0	0
Interleukin-20 family signaling	R-HSA-8854691	0.888146	0.052	0	0
FGFR4 ligand binding and activation	R-HSA-190322	0.888867	0.051	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	0.888867	0.051	0	0
Formation of axial mesoderm	R-HSA-9796292	0.888867	0.051	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	0.888867	0.051	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	0.888867	0.051	0	0
Maturation of nucleoprotein	R-HSA-9683610	0.888867	0.051	0	0
Acyl chain remodelling of PC	R-HSA-1482788	0.889007	0.051	0	0
Vpu mediated degradation of CD4	R-HSA-180534	0.889007	0.051	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	0.889007	0.051	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	0.892012	0.050	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	0.893691	0.049	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	0.894411	0.048	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	0.897100	0.047	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	0.897459	0.047	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	0.898255	0.047	0	0
Dual Incision in GG-NER	R-HSA-5696400	0.898454	0.047	0	0
eNOS activation	R-HSA-203615	0.898454	0.047	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	0.898454	0.047	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	0.898454	0.047	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	0.898454	0.047	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	0.898454	0.047	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	0.899042	0.046	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	0.899042	0.046	0	0
Complex III assembly	R-HSA-9865881	0.899042	0.046	0	0
Synthesis of DNA	R-HSA-69239	0.899337	0.046	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	0.899851	0.046	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	0.902347	0.045	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	0.902347	0.045	0	0
Hydrolysis of LPC	R-HSA-1483115	0.902347	0.045	0	0
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	0.902347	0.045	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	0.902347	0.045	0	0
Formation of the active cofactor, UDP-glucuronate	R-HSA-173599	0.902347	0.045	0	0
Non-canonical inflammasome activation	R-HSA-9686114	0.902347	0.045	0	0
Glycerophospholipid catabolism	R-HSA-6814848	0.902347	0.045	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	0.902347	0.045	0	0
Signal regulatory protein family interactions	R-HSA-391160	0.902347	0.045	0	0
Acyl chain remodeling of CL	R-HSA-1482798	0.902347	0.045	0	0
G1 Phase	R-HSA-69236	0.902589	0.045	0	0
Cyclin D associated events in G1	R-HSA-69231	0.902589	0.045	0	0
Amine ligand-binding receptors	R-HSA-375280	0.902589	0.045	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	0.903040	0.044	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	0.905922	0.043	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	0.905922	0.043	0	0
Leishmania phagocytosis	R-HSA-9664417	0.906606	0.043	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	0.906606	0.043	0	0
Parasite infection	R-HSA-9664407	0.906606	0.043	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	0.907170	0.042	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	0.907170	0.042	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	0.907170	0.042	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	0.907170	0.042	0	0
Regulation of Apoptosis	R-HSA-169911	0.907170	0.042	0	0
PERK regulates gene expression	R-HSA-381042	0.907170	0.042	0	0
HDACs deacetylate histones	R-HSA-3214815	0.908413	0.042	0	0
Cellular response to hypoxia	R-HSA-1234174	0.908503	0.042	0	0
Signaling by Insulin receptor	R-HSA-74752	0.908688	0.042	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	0.908942	0.041	0	0
Formation of the nephric duct	R-HSA-9830364	0.908942	0.041	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	0.909736	0.041	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	0.909736	0.041	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	0.910201	0.041	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	0.910201	0.041	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	0.910201	0.041	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	0.910201	0.041	0	0
SARS-CoV-2 Infection	R-HSA-9694516	0.913763	0.039	0	0
Erythropoietin activates RAS	R-HSA-9027284	0.914193	0.039	0	0
SHC1 events in EGFR signaling	R-HSA-180336	0.914193	0.039	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	0.914193	0.039	0	0
p38MAPK events	R-HSA-171007	0.914193	0.039	0	0
Protein lipoylation	R-HSA-9857492	0.914193	0.039	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	0.914193	0.039	0	0
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	0.914193	0.039	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	0.914193	0.039	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	0.914193	0.039	0	0
Formation of the anterior neural plate	R-HSA-9823739	0.914193	0.039	0	0
DNA Damage Reversal	R-HSA-73942	0.914193	0.039	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	0.915081	0.039	0	0
GPVI-mediated activation cascade	R-HSA-114604	0.915203	0.038	0	0
Triglyceride catabolism	R-HSA-163560	0.915203	0.038	0	0
Interferon Signaling	R-HSA-913531	0.916072	0.038	1	0
Regulation of endogenous retroelements	R-HSA-9842860	0.916701	0.038	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	0.917280	0.037	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	0.917926	0.037	0	0
Sphingolipid catabolism	R-HSA-9845614	0.917926	0.037	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	0.917926	0.037	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	0.917926	0.037	0	0
Kidney development	R-HSA-9830369	0.920616	0.036	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	0.921077	0.036	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	0.922289	0.035	0	0
Degradation of AXIN	R-HSA-4641257	0.922597	0.035	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	0.922597	0.035	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	0.923855	0.034	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	0.924602	0.034	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	0.924602	0.034	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	0.924602	0.034	0	0
Fructose catabolism	R-HSA-70350	0.924602	0.034	0	0
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	0.924602	0.034	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	0.924602	0.034	0	0
Activation of SMO	R-HSA-5635838	0.924602	0.034	0	0
Influenza Infection	R-HSA-168255	0.925956	0.033	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	0.926071	0.033	0	0
Signaling by BMP	R-HSA-201451	0.926071	0.033	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	0.926071	0.033	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	0.927145	0.033	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	0.928576	0.032	0	0
Intraflagellar transport	R-HSA-5620924	0.929956	0.032	0	0
NGF-stimulated transcription	R-HSA-9031628	0.929956	0.032	0	0
Phospholipid metabolism	R-HSA-1483257	0.931576	0.031	0	0
Telomere Extension By Telomerase	R-HSA-171319	0.933449	0.030	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	0.933749	0.030	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	0.933749	0.030	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	0.933749	0.030	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	0.933749	0.030	0	0
Passive transport by Aquaporins	R-HSA-432047	0.933749	0.030	0	0
Galactose catabolism	R-HSA-70370	0.933749	0.030	0	0
Coenzyme A biosynthesis	R-HSA-196783	0.933749	0.030	0	0
Response to metal ions	R-HSA-5660526	0.933749	0.030	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	0.933749	0.030	0	0
Toll-like Receptor Cascades	R-HSA-168898	0.935506	0.029	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	0.935642	0.029	0	0
Signaling by ALK	R-HSA-201556	0.935642	0.029	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	0.935642	0.029	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	0.935642	0.029	0	0
Signaling by MET	R-HSA-6806834	0.935764	0.029	0	0
PKR-mediated signaling	R-HSA-9833482	0.935764	0.029	0	0
COPII-mediated vesicle transport	R-HSA-204005	0.936152	0.029	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	0.936917	0.028	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	0.937660	0.028	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	0.937660	0.028	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	0.937660	0.028	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	0.937660	0.028	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	0.937660	0.028	0	0
MHC class II antigen presentation	R-HSA-2132295	0.937991	0.028	0	0
Platelet homeostasis	R-HSA-418346	0.938287	0.028	0	0
mRNA Capping	R-HSA-72086	0.940125	0.027	0	0
Base Excision Repair	R-HSA-73884	0.940248	0.027	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	0.940695	0.027	0	0
Post-translational protein phosphorylation	R-HSA-8957275	0.940925	0.026	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	0.941101	0.026	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	0.941374	0.026	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	0.941787	0.026	0	0
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	0.941787	0.026	0	0
Glycogen storage diseases	R-HSA-3229121	0.941787	0.026	0	0
Catecholamine biosynthesis	R-HSA-209905	0.941787	0.026	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	0.941787	0.026	0	0
Sulfide oxidation to sulfate	R-HSA-1614517	0.941787	0.026	0	0
GDP-fucose biosynthesis	R-HSA-6787639	0.941787	0.026	0	0
Choline catabolism	R-HSA-6798163	0.941787	0.026	0	0
Gene Silencing by RNA	R-HSA-211000	0.941968	0.026	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	0.944116	0.025	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	0.944165	0.025	0	0
Maturation of spike protein	R-HSA-9694548	0.946630	0.024	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	0.946630	0.024	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	0.946630	0.024	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	0.946630	0.024	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	0.946791	0.024	0	0
MITF-M-dependent gene expression	R-HSA-9856651	0.946897	0.024	0	0
IRE1alpha activates chaperones	R-HSA-381070	0.947775	0.023	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	0.948850	0.023	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	0.948850	0.023	0	0
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	0.948850	0.023	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	0.948850	0.023	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	0.948850	0.023	0	0
rRNA processing	R-HSA-72312	0.950695	0.022	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	0.950831	0.022	0	0
Cellular response to chemical stress	R-HSA-9711123	0.950941	0.022	0	0
Eukaryotic Translation Elongation	R-HSA-156842	0.951214	0.022	0	0
Amino acids regulate mTORC1	R-HSA-9639288	0.954316	0.020	0	0
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	0.955057	0.020	0	0
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	0.955057	0.020	0	0
Diseases of hemostasis	R-HSA-9671793	0.955057	0.020	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	0.955480	0.020	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	0.955851	0.020	0	0
Depyrimidination	R-HSA-73928	0.955851	0.020	0	0
Signaling by WNT in cancer	R-HSA-4791275	0.956538	0.019	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	0.958135	0.019	0	0
Signaling by NOTCH1	R-HSA-1980143	0.959352	0.018	0	0
Defective pyroptosis	R-HSA-9710421	0.959880	0.018	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	0.960271	0.018	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	0.960351	0.018	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	0.960511	0.017	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	0.960511	0.017	0	0
Pregnenolone biosynthesis	R-HSA-196108	0.960511	0.017	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	0.960511	0.017	0	0
Acyl chain remodelling of PI	R-HSA-1482922	0.960511	0.017	0	0
Creatine metabolism	R-HSA-71288	0.960511	0.017	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	0.960511	0.017	0	0
Protein hydroxylation	R-HSA-9629569	0.960511	0.017	0	0
Signaling by NODAL	R-HSA-1181150	0.960511	0.017	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	0.960511	0.017	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	0.960979	0.017	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	0.961658	0.017	0	0
Paracetamol ADME	R-HSA-9753281	0.961658	0.017	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	0.962725	0.016	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	0.962725	0.016	0	0
RSV-host interactions	R-HSA-9833110	0.962725	0.016	0	0
DAP12 interactions	R-HSA-2172127	0.963562	0.016	0	0
Gap junction trafficking	R-HSA-190828	0.963562	0.016	0	0
SARS-CoV-1 Infection	R-HSA-9678108	0.963974	0.016	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	0.964213	0.016	0	0
Miscellaneous transport and binding events	R-HSA-5223345	0.964983	0.015	0	0
Heme degradation	R-HSA-189483	0.964983	0.015	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	0.965186	0.015	0	0
Interleukin-10 signaling	R-HSA-6783783	0.965186	0.015	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	0.965303	0.015	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	0.965303	0.015	0	0
G-protein activation	R-HSA-202040	0.965303	0.015	0	0
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	0.965303	0.015	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	0.965303	0.015	0	0
Phenylalanine metabolism	R-HSA-8964208	0.965303	0.015	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	0.965303	0.015	0	0
Vitamin C (ascorbate) metabolism	R-HSA-196836	0.965303	0.015	0	0
Acyl chain remodelling of PG	R-HSA-1482925	0.965303	0.015	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	0.965555	0.015	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	0.965817	0.015	0	0
Peptide chain elongation	R-HSA-156902	0.966390	0.015	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	0.966924	0.015	0	0
Somitogenesis	R-HSA-9824272	0.966924	0.015	0	0
Gastrulation	R-HSA-9758941	0.966950	0.015	0	0
Telomere Maintenance	R-HSA-157579	0.967918	0.014	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	0.968590	0.014	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	0.968590	0.014	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	0.968590	0.014	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	0.968590	0.014	0	0
RA biosynthesis pathway	R-HSA-5365859	0.968590	0.014	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	0.968590	0.014	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	0.969514	0.013	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	0.969514	0.013	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	0.969514	0.013	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	0.969992	0.013	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	0.969992	0.013	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	0.969992	0.013	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	0.969992	0.013	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	0.969992	0.013	0	0
Dual incision in TC-NER	R-HSA-6782135	0.970642	0.013	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	0.971370	0.013	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	0.971370	0.013	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	0.971370	0.013	0	0
Acyl chain remodelling of PE	R-HSA-1482839	0.971837	0.012	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	0.972403	0.012	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	0.973164	0.012	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	0.973170	0.012	0	0
Biosynthesis of D-series resolvins	R-HSA-9018676	0.973214	0.012	0	0
Fructose metabolism	R-HSA-5652084	0.973214	0.012	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	0.973214	0.012	0	0
LDL clearance	R-HSA-8964038	0.973214	0.012	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	0.974759	0.011	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	0.974759	0.011	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	0.974877	0.011	0	0
Metal ion SLC transporters	R-HSA-425410	0.975337	0.011	0	0
tRNA Aminoacylation	R-HSA-379724	0.975493	0.011	0	0
Metabolism of polyamines	R-HSA-351202	0.975493	0.011	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	0.976465	0.010	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	0.976465	0.010	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	0.976465	0.010	0	0
Formation of the ureteric bud	R-HSA-9830674	0.976465	0.010	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	0.976465	0.010	0	0
Biosynthesis of maresins	R-HSA-9018682	0.976465	0.010	0	0
Cytoprotection by HMOX1	R-HSA-9707564	0.976575	0.010	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	0.976958	0.010	0	0
Voltage gated Potassium channels	R-HSA-1296072	0.977387	0.010	0	0
Formation of paraxial mesoderm	R-HSA-9793380	0.977626	0.010	0	0
Gap junction trafficking and regulation	R-HSA-157858	0.977658	0.010	0	0
Chemokine receptors bind chemokines	R-HSA-380108	0.977658	0.010	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	0.977936	0.010	0	0
Assembly of the pre-replicative complex	R-HSA-68867	0.978664	0.009	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	0.979322	0.009	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	0.979322	0.009	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	0.979322	0.009	0	0
Mitochondrial RNA degradation	R-HSA-9836573	0.979322	0.009	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	0.979583	0.009	0	0
Signaling by ERBB4	R-HSA-1236394	0.980372	0.009	0	0
Developmental Biology	R-HSA-1266738	0.981438	0.008	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	0.981637	0.008	0	0
The phototransduction cascade	R-HSA-2514856	0.981690	0.008	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	0.981730	0.008	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	0.981832	0.008	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	0.981832	0.008	0	0
Alpha-oxidation of phytanate	R-HSA-389599	0.981832	0.008	0	0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	0.981832	0.008	0	0
Fertilization	R-HSA-1187000	0.981832	0.008	0	0
Retinoid cycle disease events	R-HSA-2453864	0.981832	0.008	0	0
Diseases associated with visual transduction	R-HSA-2474795	0.981832	0.008	0	0
Diseases of the neuronal system	R-HSA-9675143	0.981832	0.008	0	0
Laminin interactions	R-HSA-3000157	0.981832	0.008	0	0
Pentose phosphate pathway	R-HSA-71336	0.981871	0.008	0	0
Interferon gamma signaling	R-HSA-877300	0.981874	0.008	1	1
Citric acid cycle (TCA cycle)	R-HSA-71403	0.981996	0.008	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	0.982721	0.008	0	0
Eukaryotic Translation Termination	R-HSA-72764	0.983105	0.007	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	0.983435	0.007	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	0.983777	0.007	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	0.983777	0.007	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	0.983777	0.007	0	0
Diseases of Immune System	R-HSA-5260271	0.983777	0.007	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	0.983777	0.007	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	0.983777	0.007	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	0.983777	0.007	0	0
MET activates PTK2 signaling	R-HSA-8874081	0.984037	0.007	0	0
Urea cycle	R-HSA-70635	0.984037	0.007	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	0.984037	0.007	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	0.984037	0.007	0	0
Potassium Channels	R-HSA-1296071	0.984383	0.007	0	0
Chaperonin-mediated protein folding	R-HSA-390466	0.984424	0.007	0	0
Translation of Structural Proteins	R-HSA-9694635	0.984873	0.007	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	0.984971	0.007	0	0
Interferon alpha/beta signaling	R-HSA-909733	0.985057	0.007	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	0.985487	0.006	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	0.985487	0.006	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	0.985487	0.006	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	0.985748	0.006	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	0.985908	0.006	0	0
DNA Replication	R-HSA-69306	0.985912	0.006	0	0
Protein localization	R-HSA-9609507	0.985912	0.006	0	0
Packaging Of Telomere Ends	R-HSA-171306	0.985975	0.006	0	0
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	0.985975	0.006	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	0.985975	0.006	0	0
Maturation of hRSV A proteins	R-HSA-9828806	0.985975	0.006	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	0.986460	0.006	0	0
Translation of Structural Proteins	R-HSA-9683701	0.987021	0.006	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	0.987170	0.006	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	0.987678	0.005	0	0
Insulin receptor recycling	R-HSA-77387	0.987678	0.005	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	0.987678	0.005	0	0
DNA Replication Pre-Initiation	R-HSA-69002	0.987770	0.005	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	0.987848	0.005	0	0
Activation of GABAB receptors	R-HSA-991365	0.988396	0.005	0	0
GABA B receptor activation	R-HSA-977444	0.988396	0.005	0	0
ABC-family proteins mediated transport	R-HSA-382556	0.988646	0.005	0	0
HCMV Early Events	R-HSA-9609690	0.989129	0.005	0	0
DNA methylation	R-HSA-5334118	0.989174	0.005	0	0
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	0.989174	0.005	0	0
Selenocysteine synthesis	R-HSA-2408557	0.989527	0.005	0	0
Ribosome-associated quality control	R-HSA-9948299	0.989587	0.005	0	0
Synthesis of PA	R-HSA-1483166	0.990023	0.004	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	0.990340	0.004	0	0
Neurotransmitter clearance	R-HSA-112311	0.990489	0.004	0	0
Protein folding	R-HSA-391251	0.990589	0.004	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	0.990734	0.004	0	0
Viral mRNA Translation	R-HSA-192823	0.991098	0.004	0	0
Co-inhibition by PD-1	R-HSA-389948	0.991480	0.004	0	0
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	0.991644	0.004	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	0.991798	0.004	0	0
Peroxisomal protein import	R-HSA-9033241	0.991877	0.004	0	0
Triglyceride metabolism	R-HSA-8979227	0.991877	0.004	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	0.991877	0.004	0	0
Collagen formation	R-HSA-1474290	0.992070	0.003	0	0
G alpha (s) signalling events	R-HSA-418555	0.992111	0.003	0	0
Formation of the cornified envelope	R-HSA-6809371	0.992372	0.003	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	0.992658	0.003	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	0.992658	0.003	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	0.992674	0.003	0	0
RAB geranylgeranylation	R-HSA-8873719	0.992674	0.003	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	0.992674	0.003	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	0.993550	0.003	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	0.993550	0.003	0	0
Recycling of bile acids and salts	R-HSA-159418	0.993550	0.003	0	0
Protein ubiquitination	R-HSA-8852135	0.994028	0.003	0	0
Glutamate and glutamine metabolism	R-HSA-8964539	0.994333	0.002	0	0
GPCR downstream signalling	R-HSA-388396	0.994359	0.002	1	0
Hemostasis	R-HSA-109582	0.994603	0.002	0	0
HCMV Late Events	R-HSA-9610379	0.994685	0.002	0	0
Signaling by NOTCH2	R-HSA-1980145	0.995022	0.002	0	0
Calnexin/calreticulin cycle	R-HSA-901042	0.995022	0.002	0	0
Gap junction assembly	R-HSA-190861	0.995022	0.002	0	0
Signal amplification	R-HSA-392518	0.995022	0.002	0	0
ER-Phagosome pathway	R-HSA-1236974	0.995313	0.002	0	0
ABC transporter disorders	R-HSA-5619084	0.995544	0.002	0	0
Transferrin endocytosis and recycling	R-HSA-917977	0.995626	0.002	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	0.995626	0.002	0	0
tRNA processing	R-HSA-72306	0.995839	0.002	0	0
Potential therapeutics for SARS	R-HSA-9679191	0.995934	0.002	0	0
PRC2 methylates histones and DNA	R-HSA-212300	0.996158	0.002	0	0
Glycosphingolipid transport	R-HSA-9845576	0.996158	0.002	0	0
Adipogenesis	R-HSA-9843745	0.996216	0.002	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	0.996341	0.002	0	0
SARS-CoV Infections	R-HSA-9679506	0.996602	0.001	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	0.996624	0.001	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	0.996624	0.001	0	0
Cleavage of the damaged purine	R-HSA-110331	0.996624	0.001	0	0
Phenylalanine and tyrosine metabolism	R-HSA-8963691	0.996624	0.001	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	0.996624	0.001	0	0
Lysine catabolism	R-HSA-71064	0.996624	0.001	0	0
Collagen chain trimerization	R-HSA-8948216	0.996624	0.001	0	0
Metabolism of folate and pterines	R-HSA-196757	0.996624	0.001	0	0
Leishmania parasite growth and survival	R-HSA-9664433	0.996637	0.001	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	0.996637	0.001	0	0
Nucleotide biosynthesis	R-HSA-8956320	0.996678	0.001	0	0
Amyloid fiber formation	R-HSA-977225	0.996686	0.001	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	0.996831	0.001	0	0
Depurination	R-HSA-73927	0.997035	0.001	0	0
Purine salvage	R-HSA-74217	0.997035	0.001	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	0.997062	0.001	0	0
Adaptive Immune System	R-HSA-1280218	0.997114	0.001	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	0.997211	0.001	0	0
Plasma lipoprotein clearance	R-HSA-8964043	0.997395	0.001	0	0
RAS processing	R-HSA-9648002	0.997395	0.001	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	0.997438	0.001	0	0
Metabolism of amine-derived hormones	R-HSA-209776	0.997650	0.001	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	0.997650	0.001	0	0
HCMV Infection	R-HSA-9609646	0.997687	0.001	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	0.997697	0.001	0	0
Metabolism of cofactors	R-HSA-8978934	0.997697	0.001	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	0.997711	0.001	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	0.997711	0.001	0	0
Tryptophan catabolism	R-HSA-71240	0.997711	0.001	0	0
Cellular response to starvation	R-HSA-9711097	0.997779	0.001	0	0
Aflatoxin activation and detoxification	R-HSA-5423646	0.997989	0.001	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	0.998136	0.001	0	0
G alpha (q) signalling events	R-HSA-416476	0.998189	0.001	0	0
Scavenging by Class A Receptors	R-HSA-3000480	0.998234	0.001	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	0.998234	0.001	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	0.998330	0.001	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	0.998448	0.001	0	0
GABA receptor activation	R-HSA-977443	0.998523	0.001	0	0
Glutathione conjugation	R-HSA-156590	0.998523	0.001	0	0
Signaling by Retinoic Acid	R-HSA-5362517	0.998523	0.001	0	0
Defensins	R-HSA-1461973	0.998637	0.001	0	0
Endogenous sterols	R-HSA-211976	0.998685	0.001	0	0
Collagen degradation	R-HSA-1442490	0.998685	0.001	0	0
RMTs methylate histone arginines	R-HSA-3214858	0.998803	0.001	0	0
Surfactant metabolism	R-HSA-5683826	0.998803	0.001	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	0.998803	0.001	0	0
PPARA activates gene expression	R-HSA-1989781	0.998839	0.001	0	0
SLC transporter disorders	R-HSA-5619102	0.998899	0.000	0	0
Integrin cell surface interactions	R-HSA-216083	0.998916	0.000	0	0
The canonical retinoid cycle in rods (twilight vision)	R-HSA-2453902	0.998948	0.000	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	0.998948	0.000	0	0
Innate Immune System	R-HSA-168249	0.999013	0.000	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	0.999013	0.000	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	0.999076	0.000	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	0.999108	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	0.999168	0.000	0	0
Synthesis of PC	R-HSA-1483191	0.999188	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	0.999254	0.000	1	0
Metabolism of steroid hormones	R-HSA-196071	0.999349	0.000	0	0
Signaling by GPCR	R-HSA-372790	0.999363	0.000	1	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	0.999374	0.000	0	0
Antigen processing-Cross presentation	R-HSA-1236975	0.999432	0.000	0	0
Azathioprine ADME	R-HSA-9748787	0.999450	0.000	0	0
Branched-chain amino acid catabolism	R-HSA-70895	0.999517	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	0.999534	0.000	0	0
Neddylation	R-HSA-8951664	0.999549	0.000	0	0
Immune System	R-HSA-168256	0.999556	0.000	1	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	0.999594	0.000	0	0
Retinoid metabolism and transport	R-HSA-975634	0.999594	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	0.999594	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	0.999611	0.000	0	0
FCERI mediated MAPK activation	R-HSA-2871796	0.999619	0.000	0	0
Pyruvate metabolism	R-HSA-70268	0.999638	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	0.999649	0.000	0	0
Glucuronidation	R-HSA-156588	0.999672	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	0.999679	0.000	0	0
Iron uptake and transport	R-HSA-917937	0.999747	0.000	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	0.999769	0.000	0	0
Selenoamino acid metabolism	R-HSA-2408522	0.999802	0.000	0	0
Cholesterol biosynthesis	R-HSA-191273	0.999823	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	0.999843	0.000	0	0
Nucleotide salvage	R-HSA-8956321	0.999868	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	0.999875	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	0.999876	0.000	0	0
Complex I biogenesis	R-HSA-6799198	0.999898	0.000	0	0
Digestion and absorption	R-HSA-8963743	0.999898	0.000	0	0
Xenobiotics	R-HSA-211981	0.999910	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	0.999915	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	0.999918	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	0.999922	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	0.999939	0.000	0	0
Nicotinate metabolism	R-HSA-196807	0.999939	0.000	0	0
Disorders of transmembrane transporters	R-HSA-5619115	0.999940	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	0.999947	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	0.999959	0.000	0	0
Glycosphingolipid catabolism	R-HSA-9840310	0.999959	0.000	0	0
ECM proteoglycans	R-HSA-3000178	0.999964	0.000	0	0
Purine catabolism	R-HSA-74259	0.999968	0.000	0	0
Aspirin ADME	R-HSA-9749641	0.999972	0.000	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	0.999981	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	0.999983	0.000	0	0
RNA Polymerase I Transcription	R-HSA-73864	0.999985	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	0.999986	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	0.999986	0.000	0	0
Viral Infection Pathways	R-HSA-9824446	0.999987	0.000	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	0.999987	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	0.999990	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	0.999993	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	0.999994	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	0.999994	0.000	0	0
Visual phototransduction	R-HSA-2187338	0.999995	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	0.999995	0.000	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	0.999995	0.000	0	0
Keratinization	R-HSA-6805567	0.999997	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	0.999997	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	0.999998	0.000	0	0
FCGR activation	R-HSA-2029481	0.999998	0.000	0	0
Translation	R-HSA-72766	0.999999	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	0.999999	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	0.999999	0.000	0	0
Metabolism of steroids	R-HSA-8957322	0.999999	0.000	0	0
Mitochondrial translation	R-HSA-5368287	1.000000	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	1.000000	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	1.000000	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	1.000000	0.000	0	0
Initial triggering of complement	R-HSA-166663	1.000000	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000	0.000	0	0
O-linked glycosylation	R-HSA-5173105	1.000000	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	1.000000	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000	0.000	0	0
Complement cascade	R-HSA-166658	1.000000	0.000	0	0
Post-translational protein modification	R-HSA-597592	1.000000	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	1.000000	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000	0.000	0	0
Sensory perception of taste	R-HSA-9717189	1.000000	0.000	0	0
Respiratory electron transport	R-HSA-611105	1.000000	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	1.000000	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000	0.000	1	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	1.000000	0.000	0	0
Disease	R-HSA-1643685	1.000000	0.000	1	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000	0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000	-0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000	-0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cell Cycle	R-HSA-1640170	1.776357e-15	14.750	0	0
Metabolism of RNA	R-HSA-8953854	4.251044e-13	12.372	0	0
Cell Cycle Checkpoints	R-HSA-69620	8.052448e-13	12.094	0	0
Cell Cycle, Mitotic	R-HSA-69278	4.371947e-12	11.359	0	0
M Phase	R-HSA-68886	8.520185e-12	11.070	0	0
Cell-Cell communication	R-HSA-1500931	2.924028e-11	10.534	0	0
Apoptotic execution phase	R-HSA-75153	2.838085e-11	10.547	0	0
Mitotic Prometaphase	R-HSA-68877	3.439649e-11	10.463	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.232204e-11	10.281	0	0
Eukaryotic Translation Initiation	R-HSA-72613	1.443885e-10	9.840	0	0
Cap-dependent Translation Initiation	R-HSA-72737	1.443885e-10	9.840	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	6.596266e-10	9.181	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.380537e-09	8.860	0	0
Nervous system development	R-HSA-9675108	1.473881e-09	8.832	0	0
Axon guidance	R-HSA-422475	1.780397e-09	8.749	0	0
Cellular responses to stress	R-HSA-2262752	2.648313e-09	8.577	1	0
Cellular responses to stimuli	R-HSA-8953897	3.936276e-09	8.405	1	0
Eukaryotic Translation Elongation	R-HSA-156842	6.153138e-09	8.211	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	7.215861e-09	8.142	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	7.234745e-09	8.141	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.840881e-09	8.106	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.177273e-09	8.037	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	9.151503e-09	8.039	0	0
Separation of Sister Chromatids	R-HSA-2467813	8.410032e-09	8.075	0	0
G2/M DNA damage checkpoint	R-HSA-69473	9.346319e-09	8.029	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.410185e-08	7.851	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	1.483598e-08	7.829	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.674018e-08	7.776	0	0
G2/M Checkpoints	R-HSA-69481	1.629647e-08	7.788	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.437333e-08	7.613	0	0
Mitotic Anaphase	R-HSA-68882	2.487575e-08	7.604	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.837690e-08	7.547	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.288141e-08	7.483	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.868428e-08	7.412	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.868428e-08	7.412	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	4.408860e-08	7.356	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	4.948828e-08	7.305	0	0
Cell junction organization	R-HSA-446728	4.951466e-08	7.305	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	5.718157e-08	7.243	0	0
HDACs deacetylate histones	R-HSA-3214815	5.936372e-08	7.226	0	0
mRNA Splicing	R-HSA-72172	1.875265e-07	6.727	0	0
Regulation of endogenous retroelements	R-HSA-9842860	1.948446e-07	6.710	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.981889e-07	6.703	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.031729e-07	6.692	0	0
Peptide chain elongation	R-HSA-156902	2.780797e-07	6.556	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.635537e-07	6.334	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.635537e-07	6.334	0	0
Muscle contraction	R-HSA-397014	4.995079e-07	6.301	1	0
Chromatin organization	R-HSA-4839726	5.582538e-07	6.253	0	0
Influenza Infection	R-HSA-168255	5.678114e-07	6.246	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	6.080471e-07	6.216	0	0
Interleukin-12 signaling	R-HSA-9020591	6.891289e-07	6.162	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	8.304458e-07	6.081	0	0
rRNA processing	R-HSA-72312	9.510236e-07	6.022	0	0
Adherens junctions interactions	R-HSA-418990	1.003111e-06	5.999	0	0
RNA Polymerase I Transcription	R-HSA-73864	1.042891e-06	5.982	0	0
Chromatin modifying enzymes	R-HSA-3247509	1.183972e-06	5.927	0	0
Signaling by ROBO receptors	R-HSA-376176	1.896780e-06	5.722	0	0
Apoptosis	R-HSA-109581	1.970893e-06	5.705	0	0
Estrogen-dependent gene expression	R-HSA-9018519	2.036973e-06	5.691	0	0
Smooth Muscle Contraction	R-HSA-445355	2.114853e-06	5.675	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.375212e-06	5.624	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.268766e-06	5.644	0	0
Signal Transduction	R-HSA-162582	2.409089e-06	5.618	1	0
Interleukin-12 family signaling	R-HSA-447115	2.280725e-06	5.642	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	2.547008e-06	5.594	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.737225e-06	5.563	0	0
Cell-cell junction organization	R-HSA-421270	3.225591e-06	5.491	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	3.575297e-06	5.447	0	0
DNA Double Strand Break Response	R-HSA-5693606	3.917281e-06	5.407	0	0
Nucleosome assembly	R-HSA-774815	4.176788e-06	5.379	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.176788e-06	5.379	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	4.655427e-06	5.332	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	4.624219e-06	5.335	0	0
Eukaryotic Translation Termination	R-HSA-72764	4.451680e-06	5.351	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.599060e-06	5.337	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.739648e-06	5.324	0	0
Amplification of signal from the kinetochores	R-HSA-141424	4.809369e-06	5.318	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.809369e-06	5.318	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	5.366612e-06	5.270	1	1
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.366612e-06	5.270	1	1
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.366612e-06	5.270	1	1
Signaling by RAS mutants	R-HSA-6802949	5.366612e-06	5.270	1	0
Signaling by RAF1 mutants	R-HSA-9656223	5.814902e-06	5.235	1	1
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	6.799921e-06	5.167	0	0
Post NMDA receptor activation events	R-HSA-438064	6.843418e-06	5.165	1	0
Recycling pathway of L1	R-HSA-437239	6.853130e-06	5.164	0	0
Meiotic synapsis	R-HSA-1221632	7.664747e-06	5.116	0	0
ESR-mediated signaling	R-HSA-8939211	7.520286e-06	5.124	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	8.569514e-06	5.067	1	1
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.072037e-05	4.970	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.037092e-05	4.984	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	1.474791e-05	4.831	0	0
Mitotic Prophase	R-HSA-68875	1.574068e-05	4.803	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.837794e-05	4.736	0	0
PRC2 methylates histones and DNA	R-HSA-212300	1.890620e-05	4.723	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.134013e-05	4.671	1	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.228908e-05	4.652	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	2.228908e-05	4.652	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	2.238587e-05	4.650	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	2.523526e-05	4.598	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.642733e-05	4.578	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	2.838193e-05	4.547	0	0
Selenocysteine synthesis	R-HSA-2408557	3.126961e-05	4.505	0	0
Translation initiation complex formation	R-HSA-72649	3.250911e-05	4.488	0	0
Striated Muscle Contraction	R-HSA-390522	3.415758e-05	4.467	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	3.486030e-05	4.458	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	3.550846e-05	4.450	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.044405e-05	4.393	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	3.819311e-05	4.418	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	3.814703e-05	4.419	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	4.044405e-05	4.393	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	4.031117e-05	4.395	0	0
Cellular Senescence	R-HSA-2559583	4.068716e-05	4.391	0	0
Viral mRNA Translation	R-HSA-192823	4.165503e-05	4.380	0	0
Centrosome maturation	R-HSA-380287	5.366633e-05	4.270	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	6.233495e-05	4.205	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	6.181035e-05	4.209	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	5.814309e-05	4.236	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	5.814309e-05	4.236	0	0
HSF1-dependent transactivation	R-HSA-3371571	5.818245e-05	4.235	1	1
Assembly of the pre-replicative complex	R-HSA-68867	5.841480e-05	4.233	0	0
G2/M Transition	R-HSA-69275	7.442453e-05	4.128	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.065637e-05	4.093	1	1
RNA Polymerase I Promoter Opening	R-HSA-73728	8.513760e-05	4.070	0	0
Oncogenic MAPK signaling	R-HSA-6802957	9.412341e-05	4.026	1	0
Ribosome-associated quality control	R-HSA-9948299	8.960195e-05	4.048	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	8.978761e-05	4.047	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	9.347873e-05	4.029	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	9.243415e-05	4.034	1	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	9.344636e-05	4.029	0	0
Mitotic G2-G2/M phases	R-HSA-453274	9.036231e-05	4.044	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	9.344636e-05	4.029	0	0
AURKA Activation by TPX2	R-HSA-8854518	9.872911e-05	4.006	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	1.035996e-04	3.985	1	1
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.035996e-04	3.985	0	0
Cellular response to heat stress	R-HSA-3371556	1.065033e-04	3.973	1	0
Programmed Cell Death	R-HSA-5357801	1.161125e-04	3.935	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.212779e-04	3.916	0	0
Defective pyroptosis	R-HSA-9710421	1.240988e-04	3.906	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.318768e-04	3.880	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	1.387745e-04	3.858	0	0
DNA methylation	R-HSA-5334118	1.459755e-04	3.836	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.542102e-04	3.812	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.810060e-04	3.742	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.811380e-04	3.742	0	0
Viral Infection Pathways	R-HSA-9824446	1.973299e-04	3.705	0	0
Long-term potentiation	R-HSA-9620244	2.035986e-04	3.691	1	1
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.152043e-04	3.667	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.222990e-04	3.653	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	2.230048e-04	3.652	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	2.244276e-04	3.649	0	0
DNA Replication Pre-Initiation	R-HSA-69002	2.560787e-04	3.592	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	3.169574e-04	3.499	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.169574e-04	3.499	0	0
L1CAM interactions	R-HSA-373760	3.172231e-04	3.499	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	3.269648e-04	3.485	0	0
Packaging Of Telomere Ends	R-HSA-171306	3.432184e-04	3.464	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	4.026364e-04	3.395	0	0
mTORC1-mediated signalling	R-HSA-166208	3.708782e-04	3.431	0	0
Homology Directed Repair	R-HSA-5693538	3.969694e-04	3.401	0	0
Cellular response to starvation	R-HSA-9711097	3.654661e-04	3.437	0	0
Diseases of programmed cell death	R-HSA-9645723	4.259946e-04	3.371	0	0
Signaling by VEGF	R-HSA-194138	4.265118e-04	3.370	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	4.474413e-04	3.349	0	0
Ion homeostasis	R-HSA-5578775	4.480257e-04	3.349	1	1
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	4.578588e-04	3.339	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	4.702050e-04	3.328	0	0
Signaling by ALK in cancer	R-HSA-9700206	4.702050e-04	3.328	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	4.893820e-04	3.310	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	5.915887e-04	3.228	0	0
Meiosis	R-HSA-1500620	6.243972e-04	3.205	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	7.255379e-04	3.139	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.023300e-04	3.153	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	6.649160e-04	3.177	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	6.888535e-04	3.162	0	0
HCMV Early Events	R-HSA-9609690	7.203286e-04	3.142	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	6.598607e-04	3.181	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	6.598607e-04	3.181	0	0
Developmental Biology	R-HSA-1266738	6.853641e-04	3.164	0	0
Nephrin family interactions	R-HSA-373753	6.776919e-04	3.169	0	0
MITF-M-dependent gene expression	R-HSA-9856651	7.247230e-04	3.140	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	8.025931e-04	3.096	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	8.025931e-04	3.096	0	0
MAP2K and MAPK activation	R-HSA-5674135	8.726944e-04	3.059	0	0
Epigenetic regulation of gene expression	R-HSA-212165	9.533724e-04	3.021	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.016658e-03	2.993	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.039584e-03	2.983	0	0
Gene Silencing by RNA	R-HSA-211000	1.060176e-03	2.975	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.072428e-03	2.970	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.076434e-03	2.968	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.151921e-03	2.939	1	1
Chromosome Maintenance	R-HSA-73886	1.184061e-03	2.927	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.242960e-03	2.906	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.314376e-03	2.881	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.539285e-03	2.813	0	0
Folding of actin by CCT/TriC	R-HSA-390450	1.539285e-03	2.813	0	0
Regulation of CDH1 Function	R-HSA-9764561	1.451243e-03	2.838	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.539285e-03	2.813	1	1
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	1.539285e-03	2.813	0	0
Signaling by WNT	R-HSA-195721	1.654581e-03	2.781	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.637360e-03	2.786	0	0
Cilium Assembly	R-HSA-5617833	1.583732e-03	2.800	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	1.637360e-03	2.786	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.701079e-03	2.769	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.730080e-03	2.762	0	0
Translation	R-HSA-72766	1.784286e-03	2.749	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	1.820836e-03	2.740	0	0
Protein folding	R-HSA-391251	1.839634e-03	2.735	0	0
Aggrephagy	R-HSA-9646399	1.853226e-03	2.732	0	0
Attenuation phase	R-HSA-3371568	1.853226e-03	2.732	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.858702e-03	2.731	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.967455e-03	2.706	0	0
HATs acetylate histones	R-HSA-3214847	1.968398e-03	2.706	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.029615e-03	2.693	0	0
Chaperonin-mediated protein folding	R-HSA-390466	2.128726e-03	2.672	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.196716e-03	2.658	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	2.220553e-03	2.654	0	0
Kinesins	R-HSA-983189	2.220553e-03	2.654	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.222331e-03	2.653	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.290161e-03	2.640	0	0
Cell-extracellular matrix interactions	R-HSA-446353	2.290161e-03	2.640	0	0
Protein ubiquitination	R-HSA-8852135	2.517632e-03	2.599	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	2.535138e-03	2.596	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.548078e-03	2.594	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	2.719431e-03	2.566	0	0
Ca-dependent events	R-HSA-111996	3.039903e-03	2.517	1	0
CaM pathway	R-HSA-111997	2.770310e-03	2.557	1	0
Calmodulin induced events	R-HSA-111933	2.770310e-03	2.557	1	0
HSF1 activation	R-HSA-3371511	2.770310e-03	2.557	0	0
Intracellular signaling by second messengers	R-HSA-9006925	2.824431e-03	2.549	1	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	3.039903e-03	2.517	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	2.682561e-03	2.571	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	3.039903e-03	2.517	0	0
Depyrimidination	R-HSA-73928	3.039903e-03	2.517	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	3.111989e-03	2.507	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.132583e-03	2.504	0	0
Cleavage of the damaged purine	R-HSA-110331	3.286853e-03	2.483	0	0
Semaphorin interactions	R-HSA-373755	3.301387e-03	2.481	0	0
DNA Replication	R-HSA-69306	3.557395e-03	2.449	0	0
Depurination	R-HSA-73927	3.877914e-03	2.411	0	0
Membrane Trafficking	R-HSA-199991	4.003441e-03	2.398	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	4.153189e-03	2.382	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	4.182761e-03	2.379	0	0
Meiotic recombination	R-HSA-912446	4.253374e-03	2.371	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	4.292417e-03	2.367	1	1
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	4.292417e-03	2.367	1	1
S Phase	R-HSA-69242	4.517484e-03	2.345	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.550836e-03	2.342	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.643321e-03	2.333	0	0
DAG and IP3 signaling	R-HSA-1489509	4.778292e-03	2.321	1	0
Ub-specific processing proteases	R-HSA-5689880	5.010245e-03	2.300	0	0
Signaling by Hippo	R-HSA-2028269	5.049376e-03	2.297	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	5.215474e-03	2.283	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.313262e-03	2.275	0	0
Signaling by ERBB2	R-HSA-1227986	5.508343e-03	2.259	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.653176e-03	2.248	0	0
Calcineurin activates NFAT	R-HSA-2025928	5.719545e-03	2.243	0	0
SARS-CoV-1 Infection	R-HSA-9678108	5.755988e-03	2.240	0	0
RAF activation	R-HSA-5673000	5.823306e-03	2.235	1	1
VEGFR2 mediated vascular permeability	R-HSA-5218920	6.173108e-03	2.209	0	0
PLC beta mediated events	R-HSA-112043	6.219453e-03	2.206	1	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.799529e-03	2.168	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	7.052379e-03	2.152	1	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	7.431123e-03	2.129	0	0
MTOR signalling	R-HSA-165159	8.217889e-03	2.085	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	7.431123e-03	2.129	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	7.940724e-03	2.100	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	8.049262e-03	2.094	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.861428e-03	2.104	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	7.532749e-03	2.123	1	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	7.002183e-03	2.155	0	0
Deubiquitination	R-HSA-5688426	7.431180e-03	2.129	0	0
Selenoamino acid metabolism	R-HSA-2408522	7.926881e-03	2.101	0	0
Gap junction trafficking and regulation	R-HSA-157858	8.239483e-03	2.084	0	0
Platelet degranulation	R-HSA-114608	8.664012e-03	2.062	0	0
Trafficking of AMPA receptors	R-HSA-399719	8.777901e-03	2.057	1	1
XBP1(S) activates chaperone genes	R-HSA-381038	9.125287e-03	2.040	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	9.342462e-03	2.030	0	0
Neutrophil degranulation	R-HSA-6798695	9.414117e-03	2.026	0	0
Sema4D in semaphorin signaling	R-HSA-400685	9.439918e-03	2.025	0	0
Glycolysis	R-HSA-70171	9.454755e-03	2.024	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	9.728029e-03	2.012	0	0
PKR-mediated signaling	R-HSA-9833482	9.744773e-03	2.011	0	0
Formation of definitive endoderm	R-HSA-9823730	9.774275e-03	2.010	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	9.774275e-03	2.010	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	9.774275e-03	2.010	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.028583e-02	1.988	0	0
Gap junction trafficking	R-HSA-190828	1.075265e-02	1.968	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.121849e-02	1.950	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.124547e-02	1.949	0	0
Reproduction	R-HSA-1474165	1.168691e-02	1.932	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.181867e-02	1.927	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.182338e-02	1.927	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.201667e-02	1.920	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.201667e-02	1.920	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.201667e-02	1.920	1	0
G-protein mediated events	R-HSA-112040	1.216522e-02	1.915	1	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.229166e-02	1.910	0	0
PTEN Regulation	R-HSA-6807070	1.317649e-02	1.880	0	0
COPI-mediated anterograde transport	R-HSA-6807878	1.324763e-02	1.878	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	1.348805e-02	1.870	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	1.384684e-02	1.859	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.393568e-02	1.856	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	1.395207e-02	1.855	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	1.406298e-02	1.852	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.433876e-02	1.843	0	0
Telomere Maintenance	R-HSA-157579	1.440460e-02	1.841	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.501968e-02	1.823	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.525744e-02	1.817	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.525744e-02	1.817	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.525744e-02	1.817	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.525744e-02	1.817	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.525744e-02	1.817	0	0
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.525744e-02	1.817	0	0
IRE1alpha activates chaperones	R-HSA-381070	1.565838e-02	1.805	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.586911e-02	1.799	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.607228e-02	1.794	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.031854e-02	1.692	0	0
Type I hemidesmosome assembly	R-HSA-446107	2.031854e-02	1.692	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	2.193001e-02	1.659	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.193001e-02	1.659	0	0
Ephrin signaling	R-HSA-3928664	2.193001e-02	1.659	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.818701e-02	1.740	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.106505e-02	1.676	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.843954e-02	1.734	0	0
Host Interactions of HIV factors	R-HSA-162909	2.150068e-02	1.668	0	0
Selective autophagy	R-HSA-9663891	2.190690e-02	1.659	0	0
MAPK family signaling cascades	R-HSA-5683057	1.950227e-02	1.710	1	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.007527e-02	1.697	0	0
Ion transport by P-type ATPases	R-HSA-936837	1.943076e-02	1.712	1	1
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.810878e-02	1.742	0	0
Activation of BH3-only proteins	R-HSA-114452	2.106505e-02	1.676	0	0
SARS-CoV Infections	R-HSA-9679506	2.153547e-02	1.667	0	0
Amyloid fiber formation	R-HSA-977225	2.194751e-02	1.659	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.199146e-02	1.658	0	0
HCMV Infection	R-HSA-9609646	2.244953e-02	1.649	0	0
DNA Repair	R-HSA-73894	2.271260e-02	1.644	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	2.300701e-02	1.638	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	2.337825e-02	1.631	1	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.391659e-02	1.621	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	2.425154e-02	1.615	0	0
Opioid Signalling	R-HSA-111885	2.486457e-02	1.604	1	0
RAF/MAP kinase cascade	R-HSA-5673001	2.534744e-02	1.596	1	1
Metabolism of non-coding RNA	R-HSA-194441	2.536946e-02	1.596	0	0
snRNP Assembly	R-HSA-191859	2.536946e-02	1.596	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	2.553913e-02	1.593	0	0
Base Excision Repair	R-HSA-73884	2.573395e-02	1.589	0	0
Rap1 signalling	R-HSA-392517	2.624528e-02	1.581	0	0
Hemostasis	R-HSA-109582	2.643530e-02	1.578	0	0
GP1b-IX-V activation signalling	R-HSA-430116	2.679722e-02	1.572	0	0
Unwinding of DNA	R-HSA-176974	2.679722e-02	1.572	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.705041e-02	1.568	0	0
mRNA 3'-end processing	R-HSA-72187	2.718058e-02	1.566	0	0
Interleukin-7 signaling	R-HSA-1266695	2.768188e-02	1.558	0	0
Signal regulatory protein family interactions	R-HSA-391160	2.780307e-02	1.556	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.782531e-02	1.556	0	0
Interferon Signaling	R-HSA-913531	2.789884e-02	1.554	1	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.793149e-02	1.554	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.834451e-02	1.548	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	2.834451e-02	1.548	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	2.834451e-02	1.548	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	2.919151e-02	1.535	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	3.117907e-02	1.506	0	0
Activation of ATR in response to replication stress	R-HSA-176187	3.160708e-02	1.500	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.160708e-02	1.500	1	0
Manipulation of host energy metabolism	R-HSA-9636667	3.230922e-02	1.491	0	0
Breakdown of the nuclear lamina	R-HSA-352238	3.230922e-02	1.491	0	0
Signaling by NOTCH	R-HSA-157118	3.266078e-02	1.486	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	3.384825e-02	1.470	0	0
Protein methylation	R-HSA-8876725	3.384825e-02	1.470	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	3.397513e-02	1.469	1	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.416421e-02	1.466	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.437947e-02	1.464	0	0
PI3K/AKT activation	R-HSA-198203	3.437947e-02	1.464	0	0
MHC class II antigen presentation	R-HSA-2132295	3.508724e-02	1.455	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.580206e-02	1.446	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	3.648260e-02	1.438	0	0
Basigin interactions	R-HSA-210991	3.648260e-02	1.438	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.653347e-02	1.437	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	3.677174e-02	1.434	0	0
PKMTs methylate histone lysines	R-HSA-3214841	3.816422e-02	1.418	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.950081e-02	1.403	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.956819e-02	1.403	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.996685e-02	1.398	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	4.035714e-02	1.394	0	0
Nuclear import of Rev protein	R-HSA-180746	4.035714e-02	1.394	0	0
Gap junction assembly	R-HSA-190861	4.035714e-02	1.394	0	0
Signaling by Interleukins	R-HSA-449147	4.112009e-02	1.386	0	0
Glucose metabolism	R-HSA-70326	4.129223e-02	1.384	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.244054e-02	1.372	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	5.408542e-02	1.267	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	5.408542e-02	1.267	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	5.408542e-02	1.267	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	5.408542e-02	1.267	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	5.408542e-02	1.267	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	5.408542e-02	1.267	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	5.408542e-02	1.267	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	5.408542e-02	1.267	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	5.408542e-02	1.267	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	5.408542e-02	1.267	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	5.408542e-02	1.267	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	5.408542e-02	1.267	0	0
Signaling by LTK in cancer	R-HSA-9842640	5.270612e-02	1.278	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	5.656943e-02	1.247	0	0
FGFR2 alternative splicing	R-HSA-6803529	4.897580e-02	1.310	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	5.375757e-02	1.270	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	6.035042e-02	1.219	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	6.035042e-02	1.219	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	4.709429e-02	1.327	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	5.736542e-02	1.241	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.270612e-02	1.278	0	0
Integration of provirus	R-HSA-162592	5.291438e-02	1.276	0	0
PIP3 activates AKT signaling	R-HSA-1257604	4.707206e-02	1.327	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	5.345086e-02	1.272	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.627405e-02	1.250	0	0
Regulation of TP53 Activity	R-HSA-5633007	4.869945e-02	1.312	0	0
Nef and signal transduction	R-HSA-164944	5.270612e-02	1.278	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	5.291438e-02	1.276	0	0
Potential therapeutics for SARS	R-HSA-9679191	4.606936e-02	1.337	0	0
RMTs methylate histone arginines	R-HSA-3214858	5.731180e-02	1.242	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	5.041682e-02	1.297	0	0
ISG15 antiviral mechanism	R-HSA-1169408	5.041682e-02	1.297	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	6.154354e-02	1.211	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	6.254117e-02	1.204	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.254117e-02	1.204	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	6.291731e-02	1.201	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	6.380924e-02	1.195	0	0
Neurodegenerative Diseases	R-HSA-8863678	6.380924e-02	1.195	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	6.380924e-02	1.195	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.385783e-02	1.195	0	0
Disorders of Nervous System Development	R-HSA-9697154	6.385783e-02	1.195	0	0
Pervasive developmental disorders	R-HSA-9005895	6.385783e-02	1.195	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	6.569632e-02	1.182	0	0
GAB1 signalosome	R-HSA-180292	6.569632e-02	1.182	0	0
DNA strand elongation	R-HSA-69190	6.741761e-02	1.171	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	6.766267e-02	1.170	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.766267e-02	1.170	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	6.766267e-02	1.170	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.969882e-02	1.157	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.483045e-02	1.126	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	7.496096e-02	1.125	0	0
G-protein beta:gamma signalling	R-HSA-397795	7.496096e-02	1.125	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.514028e-02	1.124	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	7.569800e-02	1.121	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	7.588928e-02	1.120	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	7.588928e-02	1.120	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	7.596607e-02	1.119	0	0
MET interacts with TNS proteins	R-HSA-8875513	7.961463e-02	1.099	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	7.961463e-02	1.099	0	0
MET activates PTPN11	R-HSA-8865999	7.961463e-02	1.099	0	0
Signaling by EGFR	R-HSA-177929	7.983120e-02	1.098	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.983120e-02	1.098	0	0
Ca2+ pathway	R-HSA-4086398	8.019764e-02	1.096	0	0
Switching of origins to a post-replicative state	R-HSA-69052	8.019764e-02	1.096	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	8.042105e-02	1.095	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	8.042105e-02	1.095	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	8.296638e-02	1.081	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	8.298000e-02	1.081	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	8.431466e-02	1.074	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	8.431466e-02	1.074	0	0
Formation of annular gap junctions	R-HSA-196025	8.431466e-02	1.074	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	8.431466e-02	1.074	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	8.431466e-02	1.074	0	0
Infectious disease	R-HSA-5663205	8.524227e-02	1.069	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	8.526686e-02	1.069	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	8.625371e-02	1.064	0	0
Negative regulation of MET activity	R-HSA-6807004	8.625371e-02	1.064	0	0
Signal transduction by L1	R-HSA-445144	8.625371e-02	1.064	0	0
Defective SFTPA2 causes IPF	R-HSA-5687868	8.871978e-02	1.052	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	8.897174e-02	1.051	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.897174e-02	1.051	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	9.048419e-02	1.043	0	0
Insulin processing	R-HSA-264876	9.048419e-02	1.043	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	9.048419e-02	1.043	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	9.765392e-02	1.010	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.025197e-01	0.989	0	0
Gap junction degradation	R-HSA-190873	1.025197e-01	0.989	0	0
ALK mutants bind TKIs	R-HSA-9700645	1.025197e-01	0.989	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.025197e-01	0.989	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.025197e-01	0.989	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.030582e-01	0.987	0	0
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.080604e-01	0.966	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	1.080604e-01	0.966	0	0
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	1.080604e-01	0.966	0	0
SARS-CoV-2 Infection	R-HSA-9694516	1.084847e-01	0.965	0	0
G1/S Transition	R-HSA-69206	1.089196e-01	0.963	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.097726e-01	0.960	0	0
Signaling by PDGFR in disease	R-HSA-9671555	1.097726e-01	0.960	0	0
G1/S-Specific Transcription	R-HSA-69205	1.098524e-01	0.959	0	0
DARPP-32 events	R-HSA-180024	1.111474e-01	0.954	0	0
Platelet calcium homeostasis	R-HSA-418360	1.111474e-01	0.954	0	0
Drug-mediated inhibition of MET activation	R-HSA-9734091	1.695731e-01	0.771	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.695731e-01	0.771	0	0
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	1.695731e-01	0.771	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.695731e-01	0.771	0	0
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	1.695731e-01	0.771	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.695731e-01	0.771	0	0
IRS activation	R-HSA-74713	1.387051e-01	0.858	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	1.387051e-01	0.858	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.221227e-01	0.913	0	0
2-LTR circle formation	R-HSA-164843	1.221227e-01	0.913	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.180930e-01	0.928	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.180930e-01	0.928	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	1.648725e-01	0.783	0	0
PI3K events in ERBB4 signaling	R-HSA-1250342	1.648725e-01	0.783	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	1.340138e-01	0.873	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.340138e-01	0.873	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.507527e-01	0.822	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.507527e-01	0.822	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.507527e-01	0.822	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.507527e-01	0.822	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	1.682377e-01	0.774	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.360490e-01	0.866	0	0
Deadenylation of mRNA	R-HSA-429947	1.501388e-01	0.824	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.447151e-01	0.839	0	0
Degradation of CDH1	R-HSA-9766229	1.656384e-01	0.781	0	0
Integrin signaling	R-HSA-354192	1.588546e-01	0.799	0	0
Activation of the pre-replicative complex	R-HSA-68962	1.223052e-01	0.913	0	0
TGFBR3 expression	R-HSA-9839394	1.648121e-01	0.783	0	0
Disorders of Developmental Biology	R-HSA-9675151	1.340138e-01	0.873	0	0
EPHB-mediated forward signaling	R-HSA-3928662	1.159758e-01	0.936	0	0
LGI-ADAM interactions	R-HSA-5682910	1.429619e-01	0.845	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	1.180930e-01	0.928	0	0
HIV Life Cycle	R-HSA-162587	1.454944e-01	0.837	0	0
PKA activation	R-HSA-163615	1.682377e-01	0.774	0	0
Synthesis of DNA	R-HSA-69239	1.492044e-01	0.826	0	0
HIV Infection	R-HSA-162906	1.232563e-01	0.909	0	0
Pyrophosphate hydrolysis	R-HSA-71737	1.387051e-01	0.858	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.340138e-01	0.873	0	0
Nectin/Necl trans heterodimerization	R-HSA-420597	1.387051e-01	0.858	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.461809e-01	0.835	0	0
Developmental Cell Lineages	R-HSA-9734767	1.527056e-01	0.816	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.387051e-01	0.858	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	1.340138e-01	0.873	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	1.588546e-01	0.799	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.296665e-01	0.887	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	1.233949e-01	0.909	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	1.427637e-01	0.845	0	0
Inhibition of PKR	R-HSA-169131	1.695731e-01	0.771	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	1.180930e-01	0.928	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	1.682377e-01	0.774	0	0
Intraflagellar transport	R-HSA-5620924	1.550079e-01	0.810	0	0
Vesicle-mediated transport	R-HSA-5653656	1.342959e-01	0.872	0	0
Signaling by TGFBR3	R-HSA-9839373	1.347718e-01	0.870	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	1.429619e-01	0.845	0	0
Platelet sensitization by LDL	R-HSA-432142	1.682377e-01	0.774	0	0
tRNA processing in the nucleus	R-HSA-6784531	1.224177e-01	0.912	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.231636e-01	0.910	0	0
Cardiac conduction	R-HSA-5576891	1.482276e-01	0.829	1	0
Transcriptional Regulation by VENTX	R-HSA-8853884	1.634789e-01	0.787	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.372026e-01	0.863	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	1.519299e-01	0.818	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	1.519299e-01	0.818	0	0
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	1.387051e-01	0.858	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.285798e-01	0.891	0	0
Hedgehog 'off' state	R-HSA-5610787	1.585995e-01	0.800	0	0
Gluconeogenesis	R-HSA-70263	1.550079e-01	0.810	0	0
NRAGE signals death through JNK	R-HSA-193648	1.467941e-01	0.833	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.159758e-01	0.936	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.634789e-01	0.787	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.393812e-01	0.856	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	1.512974e-01	0.820	0	0
Signaling by ALK	R-HSA-201556	1.407772e-01	0.851	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.682377e-01	0.774	0	0
Assembly of Viral Components at the Budding Site	R-HSA-168316	1.387051e-01	0.858	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.709352e-01	0.767	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	1.709352e-01	0.767	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	1.709352e-01	0.767	0	0
Defective CSF2RA causes SMDP4	R-HSA-5688890	1.709352e-01	0.767	0	0
Defective CSF2RB causes SMDP5	R-HSA-5688849	1.709352e-01	0.767	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	1.709352e-01	0.767	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	1.709352e-01	0.767	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.709352e-01	0.767	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	1.709352e-01	0.767	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.709352e-01	0.767	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.709352e-01	0.767	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.709352e-01	0.767	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.719856e-01	0.765	0	0
Co-inhibition by PD-1	R-HSA-389948	1.751952e-01	0.756	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.752229e-01	0.756	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	1.754065e-01	0.756	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.800273e-01	0.745	0	0
G alpha (12/13) signalling events	R-HSA-416482	1.825464e-01	0.739	0	0
Death Receptor Signaling	R-HSA-73887	1.851642e-01	0.732	0	0
Dual Incision in GG-NER	R-HSA-5696400	1.855469e-01	0.732	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.855469e-01	0.732	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	1.863940e-01	0.730	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.863940e-01	0.730	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.876910e-01	0.727	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.876910e-01	0.727	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.876910e-01	0.727	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.876910e-01	0.727	0	0
Signaling by LTK	R-HSA-9842663	1.876910e-01	0.727	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	1.876938e-01	0.727	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.948761e-01	0.710	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.957411e-01	0.708	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.957411e-01	0.708	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.957411e-01	0.708	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.957411e-01	0.708	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	1.974764e-01	0.704	0	0
Autophagy	R-HSA-9612973	1.983450e-01	0.703	0	0
Orc1 removal from chromatin	R-HSA-68949	1.994201e-01	0.700	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	1.994201e-01	0.700	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	1.994201e-01	0.700	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.995100e-01	0.700	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.995100e-01	0.700	0	0
Transmission across Chemical Synapses	R-HSA-112315	2.006441e-01	0.698	1	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.013768e-01	0.696	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.042286e-01	0.690	0	0
Autointegration results in viral DNA circles	R-HSA-177539	2.042286e-01	0.690	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.042286e-01	0.690	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.050493e-01	0.688	0	0
Regulation of mitotic cell cycle	R-HSA-453276	2.050493e-01	0.688	0	0
Protein hydroxylation	R-HSA-9629569	2.051450e-01	0.688	0	0
Nucleotide Excision Repair	R-HSA-5696398	2.060705e-01	0.686	0	0
Formation of axial mesoderm	R-HSA-9796292	2.112575e-01	0.675	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.112610e-01	0.675	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.112610e-01	0.675	0	0
HIV elongation arrest and recovery	R-HSA-167287	2.119081e-01	0.674	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	2.119081e-01	0.674	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	2.119081e-01	0.674	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	2.119081e-01	0.674	1	1
Regulation of TP53 Degradation	R-HSA-6804757	2.138448e-01	0.670	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.138448e-01	0.670	0	0
RET signaling	R-HSA-8853659	2.138448e-01	0.670	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.154403e-01	0.667	0	0
Regulation of insulin secretion	R-HSA-422356	2.199449e-01	0.658	0	0
Gene expression (Transcription)	R-HSA-74160	2.235089e-01	0.651	1	0
Macroautophagy	R-HSA-1632852	2.235819e-01	0.651	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.244135e-01	0.649	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.244135e-01	0.649	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	2.244135e-01	0.649	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.265062e-01	0.645	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.284823e-01	0.641	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	2.432572e-01	0.614	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.432572e-01	0.614	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	2.432572e-01	0.614	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	2.432572e-01	0.614	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	2.432572e-01	0.614	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	2.432572e-01	0.614	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	2.432572e-01	0.614	0	0
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.432572e-01	0.614	0	0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	2.432572e-01	0.614	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	2.432572e-01	0.614	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	2.432572e-01	0.614	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.432572e-01	0.614	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.104072e-01	0.508	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.104072e-01	0.508	0	0
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.104072e-01	0.508	0	0
MECP2 regulates transcription factors	R-HSA-9022707	2.381434e-01	0.623	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	2.381434e-01	0.623	0	0
SOS-mediated signalling	R-HSA-112412	2.381434e-01	0.623	0	0
Axonal growth stimulation	R-HSA-209563	3.716022e-01	0.430	0	0
Invadopodia formation	R-HSA-8941237	3.716022e-01	0.430	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	2.723076e-01	0.565	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	2.723076e-01	0.565	0	0
MET receptor recycling	R-HSA-8875656	2.723076e-01	0.565	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.273700e-01	0.369	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	4.273700e-01	0.369	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	2.600254e-01	0.585	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.600254e-01	0.585	0	0
Binding and entry of HIV virion	R-HSA-173107	3.401934e-01	0.468	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	3.401934e-01	0.468	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.849419e-01	0.545	0	0
Phosphorylation of the APC/C	R-HSA-176412	2.849419e-01	0.545	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	2.641957e-01	0.578	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	3.100387e-01	0.509	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	3.100387e-01	0.509	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.734454e-01	0.428	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.734454e-01	0.428	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.603069e-01	0.443	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	3.603069e-01	0.443	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	2.400206e-01	0.620	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	2.357160e-01	0.628	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.482954e-01	0.605	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	3.466822e-01	0.460	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.852704e-01	0.414	0	0
Polymerase switching	R-HSA-69091	4.377042e-01	0.359	0	0
Leading Strand Synthesis	R-HSA-69109	4.377042e-01	0.359	0	0
Scavenging by Class F Receptors	R-HSA-3000484	4.377042e-01	0.359	0	0
Signaling by ERBB4	R-HSA-1236394	2.368335e-01	0.626	0	0
Dual incision in TC-NER	R-HSA-6782135	2.740674e-01	0.562	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.883049e-01	0.411	0	0
Formation of the Early Elongation Complex	R-HSA-113418	3.883049e-01	0.411	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.908527e-01	0.536	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	3.255202e-01	0.487	0	0
Lagging Strand Synthesis	R-HSA-69186	4.344102e-01	0.362	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	3.869753e-01	0.412	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	4.584368e-01	0.339	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	3.849624e-01	0.415	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	4.032969e-01	0.394	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.245089e-01	0.372	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	3.670601e-01	0.435	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	4.499041e-01	0.347	0	0
HIV Transcription Elongation	R-HSA-167169	4.424655e-01	0.354	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.424655e-01	0.354	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.424655e-01	0.354	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.516061e-01	0.599	0	0
Signaling by MET	R-HSA-6806834	4.319833e-01	0.365	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.413811e-01	0.617	0	0
EGFR downregulation	R-HSA-182971	4.499041e-01	0.347	0	0
Myogenesis	R-HSA-525793	3.466822e-01	0.460	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.275421e-01	0.485	0	0
G0 and Early G1	R-HSA-1538133	2.801778e-01	0.553	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	3.401934e-01	0.468	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.883118e-01	0.411	0	0
DAP12 signaling	R-HSA-2424491	4.295498e-01	0.367	0	0
Germ layer formation at gastrulation	R-HSA-9754189	3.852704e-01	0.414	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.706497e-01	0.431	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	3.064102e-01	0.514	0	0
Regulation of CDH11 function	R-HSA-9762292	3.401934e-01	0.468	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.059947e-01	0.391	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.742753e-01	0.562	0	0
Co-inhibition by CTLA4	R-HSA-389513	4.099980e-01	0.387	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	4.584368e-01	0.339	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.059947e-01	0.391	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.368335e-01	0.626	0	0
Generation of second messenger molecules	R-HSA-202433	4.424655e-01	0.354	0	0
Regulation of gap junction activity	R-HSA-191650	4.273700e-01	0.369	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	2.845591e-01	0.546	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	3.675136e-01	0.435	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	3.466822e-01	0.460	0	0
ER-Phagosome pathway	R-HSA-1236974	3.061310e-01	0.514	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	4.179435e-01	0.379	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	3.051404e-01	0.516	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.587682e-01	0.587	0	0
Repression of WNT target genes	R-HSA-4641265	4.377042e-01	0.359	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	4.311698e-01	0.365	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.211537e-01	0.376	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	3.258702e-01	0.487	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.354178e-01	0.628	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	2.354178e-01	0.628	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	4.273700e-01	0.369	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.600254e-01	0.585	0	0
Formation of the posterior neural plate	R-HSA-9832991	3.734454e-01	0.428	0	0
Metalloprotease DUBs	R-HSA-5689901	3.466822e-01	0.460	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.550200e-01	0.593	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	3.701425e-01	0.432	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.466822e-01	0.460	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	2.381434e-01	0.623	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.849419e-01	0.545	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	2.435059e-01	0.613	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	4.297711e-01	0.367	0	0
TCR signaling	R-HSA-202403	3.480646e-01	0.458	0	0
eNOS activation	R-HSA-203615	3.338546e-01	0.476	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	3.706497e-01	0.431	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	3.706497e-01	0.431	0	0
Co-stimulation by CD28	R-HSA-389356	2.677759e-01	0.572	0	0
GPVI-mediated activation cascade	R-HSA-114604	3.701425e-01	0.432	0	0
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.104072e-01	0.508	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.104072e-01	0.508	0	0
MET activates STAT3	R-HSA-8875791	3.716022e-01	0.430	0	0
Co-stimulation by ICOS	R-HSA-9927354	2.723076e-01	0.565	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.273700e-01	0.369	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.273700e-01	0.369	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	3.401934e-01	0.468	0	0
PKA activation in glucagon signalling	R-HSA-164378	3.603069e-01	0.443	0	0
VLDLR internalisation and degradation	R-HSA-8866427	4.377042e-01	0.359	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	3.551235e-01	0.450	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	4.032969e-01	0.394	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	4.424655e-01	0.354	0	0
PI3K Cascade	R-HSA-109704	4.519683e-01	0.345	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	2.477302e-01	0.606	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	2.979111e-01	0.526	0	0
HDMs demethylate histones	R-HSA-3214842	3.258702e-01	0.487	0	0
Polo-like kinase mediated events	R-HSA-156711	3.603069e-01	0.443	0	0
Adaptive Immune System	R-HSA-1280218	3.580075e-01	0.446	0	0
PCP/CE pathway	R-HSA-4086400	2.817461e-01	0.550	0	0
Platelet homeostasis	R-HSA-418346	3.067818e-01	0.513	0	0
Antigen processing-Cross presentation	R-HSA-1236975	3.272742e-01	0.485	0	0
Interferon gamma signaling	R-HSA-877300	3.822783e-01	0.418	1	1
Signal attenuation	R-HSA-74749	3.401934e-01	0.468	0	0
Diseases associated with surfactant metabolism	R-HSA-5687613	4.377042e-01	0.359	0	0
TBC/RABGAPs	R-HSA-8854214	3.381019e-01	0.471	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	3.058934e-01	0.514	0	0
RNA Polymerase II Transcription	R-HSA-73857	4.565200e-01	0.341	1	0
CHL1 interactions	R-HSA-447041	2.381434e-01	0.623	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.064102e-01	0.514	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.064102e-01	0.514	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	2.641957e-01	0.578	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	2.845591e-01	0.546	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.675136e-01	0.435	0	0
Integration of energy metabolism	R-HSA-163685	4.523400e-01	0.345	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	2.381434e-01	0.623	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.377042e-01	0.359	0	0
Rab regulation of trafficking	R-HSA-9007101	4.435661e-01	0.353	0	0
HCMV Late Events	R-HSA-9610379	3.645251e-01	0.438	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.584368e-01	0.339	0	0
Signaling by PTK6	R-HSA-8848021	3.412029e-01	0.467	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	3.412029e-01	0.467	0	0
Intracellular oxygen transport	R-HSA-8981607	3.716022e-01	0.430	0	0
ARMS-mediated activation	R-HSA-170984	3.064102e-01	0.514	0	0
NADE modulates death signalling	R-HSA-205025	4.273700e-01	0.369	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	3.401934e-01	0.468	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.845591e-01	0.546	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	3.158183e-01	0.501	0	0
Creatine metabolism	R-HSA-71288	4.099980e-01	0.387	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	4.295498e-01	0.367	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	3.651231e-01	0.438	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	4.583925e-01	0.339	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.388604e-01	0.622	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	3.402808e-01	0.468	0	0
Signaling by FGFR in disease	R-HSA-1226099	3.541553e-01	0.451	0	0
Signaling by NOTCH4	R-HSA-9013694	3.541553e-01	0.451	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	3.158183e-01	0.501	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	3.065943e-01	0.513	0	0
Histamine receptors	R-HSA-390650	3.716022e-01	0.430	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.641957e-01	0.578	0	0
Suppression of apoptosis	R-HSA-9635465	3.734454e-01	0.428	0	0
PECAM1 interactions	R-HSA-210990	3.734454e-01	0.428	0	0
Immune System	R-HSA-168256	2.900827e-01	0.537	1	0
Signaling by FGFR2	R-HSA-5654738	4.319833e-01	0.365	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.600254e-01	0.585	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	3.852704e-01	0.414	0	0
Syndecan interactions	R-HSA-3000170	2.845591e-01	0.546	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.610853e-01	0.583	0	0
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.104072e-01	0.508	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.381434e-01	0.623	0	0
Interleukin-18 signaling	R-HSA-9012546	2.723076e-01	0.565	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.064102e-01	0.514	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.401934e-01	0.468	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.059947e-01	0.391	0	0
Sodium/Calcium exchangers	R-HSA-425561	4.059947e-01	0.391	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.979111e-01	0.526	0	0
Sensory processing of sound	R-HSA-9659379	2.933474e-01	0.533	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	3.064102e-01	0.514	0	0
Maturation of nucleoprotein	R-HSA-9694631	3.852704e-01	0.414	0	0
Signaling by Hedgehog	R-HSA-5358351	3.703835e-01	0.431	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.381434e-01	0.623	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	3.064102e-01	0.514	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.600254e-01	0.585	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.400206e-01	0.620	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	4.099980e-01	0.387	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	4.099980e-01	0.387	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.245089e-01	0.372	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	4.380297e-01	0.358	0	0
Ion channel transport	R-HSA-983712	3.806632e-01	0.419	1	0
FOXO-mediated transcription	R-HSA-9614085	4.444578e-01	0.352	0	0
Specification of primordial germ cells	R-HSA-9827857	3.351967e-01	0.475	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.482768e-01	0.605	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.064102e-01	0.514	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.482954e-01	0.605	0	0
Other interleukin signaling	R-HSA-449836	3.852704e-01	0.414	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.344102e-01	0.362	0	0
Signaling by Leptin	R-HSA-2586552	3.401934e-01	0.468	0	0
STING mediated induction of host immune responses	R-HSA-1834941	3.852704e-01	0.414	0	0
Interleukin-37 signaling	R-HSA-9008059	4.295498e-01	0.367	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	4.594331e-01	0.338	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	4.602836e-01	0.337	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.602836e-01	0.337	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.684668e-01	0.329	0	0
Frs2-mediated activation	R-HSA-170968	4.684668e-01	0.329	0	0
Maturation of nucleoprotein	R-HSA-9683610	4.684668e-01	0.329	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	4.781917e-01	0.320	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	4.781917e-01	0.320	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.781917e-01	0.320	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	4.781917e-01	0.320	0	0
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	4.781917e-01	0.320	0	0
NrCAM interactions	R-HSA-447038	4.781917e-01	0.320	0	0
Co-inhibition by BTLA	R-HSA-9927353	4.781917e-01	0.320	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	4.781917e-01	0.320	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	4.788009e-01	0.320	0	0
Notch-HLH transcription pathway	R-HSA-350054	4.820166e-01	0.317	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.820166e-01	0.317	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	4.820166e-01	0.317	0	0
LDL clearance	R-HSA-8964038	4.820166e-01	0.317	0	0
Inositol phosphate metabolism	R-HSA-1483249	4.827804e-01	0.316	0	0
Signaling by TGFB family members	R-HSA-9006936	4.874088e-01	0.312	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	4.887474e-01	0.311	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	4.898583e-01	0.310	0	0
Nuclear RNA decay	R-HSA-9930044	4.898583e-01	0.310	0	0
Cardiogenesis	R-HSA-9733709	4.898583e-01	0.310	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	4.898583e-01	0.310	0	0
Retrograde neurotrophin signalling	R-HSA-177504	4.982007e-01	0.303	0	0
Malate-aspartate shuttle	R-HSA-9856872	4.982007e-01	0.303	0	0
Regulation of KIT signaling	R-HSA-1433559	4.982007e-01	0.303	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	4.982007e-01	0.303	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	4.993863e-01	0.302	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	5.014436e-01	0.300	0	0
IGF1R signaling cascade	R-HSA-2428924	5.032305e-01	0.298	0	0
Interleukin receptor SHC signaling	R-HSA-912526	5.050964e-01	0.297	0	0
Growth hormone receptor signaling	R-HSA-982772	5.050964e-01	0.297	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.093827e-01	0.293	0	0
Resolution of D-Loop Structures	R-HSA-5693537	5.093827e-01	0.293	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	5.126133e-01	0.290	0	0
Signaling by SCF-KIT	R-HSA-1433557	5.126133e-01	0.290	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	5.175760e-01	0.286	0	0
Plus-strand DNA synthesis	R-HSA-164525	5.245056e-01	0.280	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.245056e-01	0.280	0	0
Phosphorylation of Emi1	R-HSA-176417	5.245056e-01	0.280	0	0
PKB-mediated events	R-HSA-109703	5.245056e-01	0.280	0	0
PDE3B signalling	R-HSA-165160	5.245056e-01	0.280	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.245056e-01	0.280	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.245056e-01	0.280	0	0
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	5.245056e-01	0.280	0	0
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	5.245056e-01	0.280	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	5.245056e-01	0.280	0	0
Pentose phosphate pathway disease	R-HSA-6791465	5.245056e-01	0.280	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	5.245056e-01	0.280	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	5.245056e-01	0.280	0	0
Cam-PDE 1 activation	R-HSA-111957	5.245056e-01	0.280	0	0
Synthesis of PS	R-HSA-1483101	5.245056e-01	0.280	0	0
Intestinal hexose absorption	R-HSA-8981373	5.245056e-01	0.280	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	5.245056e-01	0.280	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	5.245056e-01	0.280	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	5.245056e-01	0.280	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.245056e-01	0.280	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.245056e-01	0.280	0	0
Processive synthesis on the lagging strand	R-HSA-69183	5.268464e-01	0.278	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	5.268464e-01	0.278	0	0
DCC mediated attractive signaling	R-HSA-418885	5.268464e-01	0.278	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.268464e-01	0.278	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.268464e-01	0.278	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.268464e-01	0.278	0	0
Formation of the anterior neural plate	R-HSA-9823739	5.268464e-01	0.278	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	5.276312e-01	0.278	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	5.276312e-01	0.278	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	5.276312e-01	0.278	0	0
Signal amplification	R-HSA-392518	5.285611e-01	0.277	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	5.285611e-01	0.277	0	0
Calnexin/calreticulin cycle	R-HSA-901042	5.285611e-01	0.277	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	5.380677e-01	0.269	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	5.380677e-01	0.269	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	5.380677e-01	0.269	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.457952e-01	0.263	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	5.458687e-01	0.263	0	0
TNF signaling	R-HSA-75893	5.458687e-01	0.263	0	0
Fanconi Anemia Pathway	R-HSA-6783310	5.463076e-01	0.263	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	5.463076e-01	0.263	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	5.463076e-01	0.263	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	5.463076e-01	0.263	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	5.473653e-01	0.262	0	0
Regulation of Apoptosis	R-HSA-169911	5.473653e-01	0.262	0	0
Oncogene Induced Senescence	R-HSA-2559585	5.473653e-01	0.262	0	0
Tight junction interactions	R-HSA-420029	5.495832e-01	0.260	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.495832e-01	0.260	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	5.495832e-01	0.260	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	5.543627e-01	0.256	0	0
Prolonged ERK activation events	R-HSA-169893	5.543627e-01	0.256	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	5.543627e-01	0.256	0	0
Activation of SMO	R-HSA-5635838	5.543627e-01	0.256	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	5.543627e-01	0.256	0	0
Virus Assembly and Release	R-HSA-168268	5.543627e-01	0.256	0	0
IRS-mediated signalling	R-HSA-112399	5.608398e-01	0.251	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	5.627316e-01	0.250	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	5.627316e-01	0.250	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	5.657703e-01	0.247	0	0
RNA Polymerase III Transcription	R-HSA-74158	5.657703e-01	0.247	0	0
FLT3 signaling in disease	R-HSA-9682385	5.657703e-01	0.247	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.667114e-01	0.247	0	0
Erythropoietin activates STAT5	R-HSA-9027283	5.667114e-01	0.247	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	5.667114e-01	0.247	0	0
Uncoating of the HIV Virion	R-HSA-162585	5.667114e-01	0.247	0	0
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	5.667114e-01	0.247	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	5.667114e-01	0.247	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	5.667114e-01	0.247	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.667114e-01	0.247	0	0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	5.667114e-01	0.247	0	0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	5.667114e-01	0.247	0	0
MET Receptor Activation	R-HSA-6806942	5.667114e-01	0.247	0	0
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	5.667114e-01	0.247	0	0
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	5.667114e-01	0.247	0	0
G2/M DNA replication checkpoint	R-HSA-69478	5.667114e-01	0.247	0	0
Neurofascin interactions	R-HSA-447043	5.667114e-01	0.247	0	0
VLDL assembly	R-HSA-8866423	5.667114e-01	0.247	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	5.771310e-01	0.239	0	0
Signaling by NTRKs	R-HSA-166520	5.775978e-01	0.238	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.807245e-01	0.236	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	5.807245e-01	0.236	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	5.807245e-01	0.236	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.807245e-01	0.236	0	0
Gastrulation	R-HSA-9758941	5.868059e-01	0.232	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.916207e-01	0.228	0	0
GPER1 signaling	R-HSA-9634597	5.946454e-01	0.226	0	0
MET promotes cell motility	R-HSA-8875878	6.012998e-01	0.221	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	6.051732e-01	0.218	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.051732e-01	0.218	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.051732e-01	0.218	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.051732e-01	0.218	0	0
Recycling of eIF2:GDP	R-HSA-72731	6.051732e-01	0.218	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.051732e-01	0.218	0	0
Disinhibition of SNARE formation	R-HSA-114516	6.051732e-01	0.218	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.051732e-01	0.218	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.051732e-01	0.218	0	0
VLDL clearance	R-HSA-8964046	6.051732e-01	0.218	0	0
LDL remodeling	R-HSA-8964041	6.051732e-01	0.218	0	0
Regulation of PTEN localization	R-HSA-8948747	6.051732e-01	0.218	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	6.051732e-01	0.218	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.051732e-01	0.218	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.051732e-01	0.218	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	6.059199e-01	0.218	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.059199e-01	0.218	0	0
Choline catabolism	R-HSA-6798163	6.059199e-01	0.218	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.059199e-01	0.218	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.059199e-01	0.218	0	0
Stabilization of p53	R-HSA-69541	6.183906e-01	0.209	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	6.183906e-01	0.209	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.183906e-01	0.209	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	6.183906e-01	0.209	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	6.194031e-01	0.208	0	0
Regulation of RAS by GAPs	R-HSA-5658442	6.252183e-01	0.204	0	0
Azathioprine ADME	R-HSA-9748787	6.252183e-01	0.204	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.299484e-01	0.201	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.299484e-01	0.201	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.299484e-01	0.201	0	0
Nephron development	R-HSA-9831926	6.299484e-01	0.201	0	0
Mismatch Repair	R-HSA-5358508	6.299484e-01	0.201	0	0
Tie2 Signaling	R-HSA-210993	6.299484e-01	0.201	0	0
Signaling by Erythropoietin	R-HSA-9006335	6.310330e-01	0.200	0	0
Late endosomal microautophagy	R-HSA-9615710	6.310330e-01	0.200	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.310330e-01	0.200	0	0
Heme signaling	R-HSA-9707616	6.318908e-01	0.199	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.350146e-01	0.197	0	0
Glycogen metabolism	R-HSA-8982491	6.350146e-01	0.197	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	6.399732e-01	0.194	0	0
Reverse Transcription of HIV RNA	R-HSA-162589	6.402229e-01	0.194	0	0
Minus-strand DNA synthesis	R-HSA-164516	6.402229e-01	0.194	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.402229e-01	0.194	0	0
phospho-PLA2 pathway	R-HSA-111995	6.402229e-01	0.194	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.402229e-01	0.194	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.402229e-01	0.194	0	0
TGFBR3 PTM regulation	R-HSA-9839383	6.402229e-01	0.194	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	6.402229e-01	0.194	0	0
SLC-mediated bile acid transport	R-HSA-9958517	6.402229e-01	0.194	0	0
Adrenoceptors	R-HSA-390696	6.402229e-01	0.194	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.402229e-01	0.194	0	0
Intestinal absorption	R-HSA-8963676	6.402229e-01	0.194	0	0
Interleukin-23 signaling	R-HSA-9020933	6.402229e-01	0.194	0	0
Disease	R-HSA-1643685	6.464473e-01	0.189	1	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	6.497229e-01	0.187	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	6.497229e-01	0.187	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	6.497229e-01	0.187	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	6.497229e-01	0.187	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	6.528184e-01	0.185	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.528184e-01	0.185	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	6.528184e-01	0.185	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.528184e-01	0.185	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.528184e-01	0.185	0	0
Regulation of signaling by CBL	R-HSA-912631	6.528184e-01	0.185	0	0
Generic Transcription Pathway	R-HSA-212436	6.531281e-01	0.185	1	0
Neurexins and neuroligins	R-HSA-6794361	6.543620e-01	0.184	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	6.559536e-01	0.183	0	0
Insulin receptor signalling cascade	R-HSA-74751	6.583424e-01	0.182	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	6.611792e-01	0.180	0	0
UCH proteinases	R-HSA-5689603	6.626793e-01	0.179	0	0
Neuronal System	R-HSA-112316	6.635286e-01	0.178	1	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	6.668257e-01	0.176	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	6.668257e-01	0.176	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	6.668257e-01	0.176	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	6.677276e-01	0.175	0	0
Lipophagy	R-HSA-9613354	6.721631e-01	0.173	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	6.721631e-01	0.173	0	0
p75NTR regulates axonogenesis	R-HSA-193697	6.721631e-01	0.173	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	6.721631e-01	0.173	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	6.721631e-01	0.173	0	0
Regulation of signaling by NODAL	R-HSA-1433617	6.721631e-01	0.173	0	0
WNT mediated activation of DVL	R-HSA-201688	6.721631e-01	0.173	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	6.721631e-01	0.173	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	6.721631e-01	0.173	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	6.721631e-01	0.173	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	6.721631e-01	0.173	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	6.745462e-01	0.171	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.745462e-01	0.171	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.745462e-01	0.171	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.745462e-01	0.171	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.745462e-01	0.171	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.745462e-01	0.171	0	0
Signaling by NODAL	R-HSA-1181150	6.745462e-01	0.171	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	6.745462e-01	0.171	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	6.820005e-01	0.166	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	6.820005e-01	0.166	0	0
Signaling by FGFR	R-HSA-190236	6.820144e-01	0.166	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.850459e-01	0.164	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	6.850459e-01	0.164	0	0
Integrin cell surface interactions	R-HSA-216083	6.860023e-01	0.164	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	6.951545e-01	0.158	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	6.951545e-01	0.158	0	0
G-protein activation	R-HSA-202040	6.951545e-01	0.158	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	6.951545e-01	0.158	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	6.951545e-01	0.158	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	6.951545e-01	0.158	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.951545e-01	0.158	0	0
ERK/MAPK targets	R-HSA-198753	6.951545e-01	0.158	0	0
G alpha (z) signalling events	R-HSA-418597	6.952704e-01	0.158	0	0
Signaling by NOTCH3	R-HSA-9012852	6.952704e-01	0.158	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	6.966836e-01	0.157	0	0
Metabolism of proteins	R-HSA-392499	6.976454e-01	0.156	0	0
Downstream TCR signaling	R-HSA-202424	6.994560e-01	0.155	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.012694e-01	0.154	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.012694e-01	0.154	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.012694e-01	0.154	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.012694e-01	0.154	0	0
CASP4 inflammasome assembly	R-HSA-9948001	7.012694e-01	0.154	0	0
Tandem pore domain potassium channels	R-HSA-1296346	7.012694e-01	0.154	0	0
Interleukin-27 signaling	R-HSA-9020956	7.012694e-01	0.154	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	7.012694e-01	0.154	0	0
Maturation of spike protein	R-HSA-9683686	7.012694e-01	0.154	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	7.016533e-01	0.154	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	7.081408e-01	0.150	0	0
Proteasome assembly	R-HSA-9907900	7.108743e-01	0.148	0	0
DAP12 interactions	R-HSA-2172127	7.108743e-01	0.148	0	0
Netrin-1 signaling	R-HSA-373752	7.108743e-01	0.148	0	0
Surfactant metabolism	R-HSA-5683826	7.108743e-01	0.148	0	0
Adipogenesis	R-HSA-9843745	7.110346e-01	0.148	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.146706e-01	0.146	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.146706e-01	0.146	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.146706e-01	0.146	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	7.176362e-01	0.144	0	0
Vpu mediated degradation of CD4	R-HSA-180534	7.176362e-01	0.144	0	0
Miscellaneous transport and binding events	R-HSA-5223345	7.176362e-01	0.144	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.277931e-01	0.138	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	7.277931e-01	0.138	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	7.277931e-01	0.138	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	7.277931e-01	0.138	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	7.277931e-01	0.138	0	0
Signaling by APC mutants	R-HSA-4839744	7.277931e-01	0.138	0	0
vRNA Synthesis	R-HSA-192814	7.277931e-01	0.138	0	0
vRNP Assembly	R-HSA-192905	7.277931e-01	0.138	0	0
Chylomicron assembly	R-HSA-8963888	7.277931e-01	0.138	0	0
Bicarbonate transporters	R-HSA-425381	7.277931e-01	0.138	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	7.277931e-01	0.138	0	0
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	7.277931e-01	0.138	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.277931e-01	0.138	0	0
Dissolution of Fibrin Clot	R-HSA-75205	7.277931e-01	0.138	0	0
Signaling by Insulin receptor	R-HSA-74752	7.296608e-01	0.137	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.302901e-01	0.137	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	7.302901e-01	0.137	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	7.329214e-01	0.135	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.329214e-01	0.135	0	0
Mitophagy	R-HSA-5205647	7.329214e-01	0.135	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.329214e-01	0.135	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.329214e-01	0.135	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	7.329214e-01	0.135	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	7.331261e-01	0.135	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.331261e-01	0.135	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.331261e-01	0.135	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.331261e-01	0.135	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.331261e-01	0.135	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	7.331261e-01	0.135	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.331261e-01	0.135	0	0
Signaling by KIT in disease	R-HSA-9669938	7.331261e-01	0.135	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	7.377834e-01	0.132	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	7.475463e-01	0.126	0	0
Signalling to ERKs	R-HSA-187687	7.475463e-01	0.126	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	7.475463e-01	0.126	0	0
Synthesis of PC	R-HSA-1483191	7.505085e-01	0.125	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.505553e-01	0.125	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.505553e-01	0.125	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	7.505553e-01	0.125	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.517364e-01	0.124	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.519633e-01	0.124	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.519633e-01	0.124	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	7.519633e-01	0.124	0	0
Proton-coupled monocarboxylate transport	R-HSA-433692	7.519633e-01	0.124	0	0
Plasmalogen biosynthesis	R-HSA-75896	7.519633e-01	0.124	0	0
ERKs are inactivated	R-HSA-202670	7.519633e-01	0.124	0	0
Signaling by AMER1 mutants	R-HSA-4839748	7.519633e-01	0.124	0	0
Signaling by AXIN mutants	R-HSA-4839735	7.519633e-01	0.124	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	7.519633e-01	0.124	0	0
Activation of RAC1	R-HSA-428540	7.519633e-01	0.124	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.519633e-01	0.124	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.519633e-01	0.124	0	0
tRNA Aminoacylation	R-HSA-379724	7.557659e-01	0.122	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.577383e-01	0.120	0	0
Protein-protein interactions at synapses	R-HSA-6794362	7.592056e-01	0.120	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	7.615231e-01	0.118	0	0
NGF-stimulated transcription	R-HSA-9031628	7.627540e-01	0.118	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	7.662471e-01	0.116	0	0
MAP kinase activation	R-HSA-450294	7.667150e-01	0.115	0	0
Aquaporin-mediated transport	R-HSA-445717	7.667150e-01	0.115	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	7.669950e-01	0.115	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.669950e-01	0.115	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.669950e-01	0.115	0	0
Mitochondrial RNA degradation	R-HSA-9836573	7.669950e-01	0.115	0	0
Plasma lipoprotein assembly	R-HSA-8963898	7.669950e-01	0.115	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.685788e-01	0.114	0	0
MET activates RAS signaling	R-HSA-8851805	7.739886e-01	0.111	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.739886e-01	0.111	0	0
Maple Syrup Urine Disease	R-HSA-9865114	7.739886e-01	0.111	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	7.739886e-01	0.111	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	7.739886e-01	0.111	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	7.739886e-01	0.111	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	7.739886e-01	0.111	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	7.739886e-01	0.111	0	0
GRB2 events in EGFR signaling	R-HSA-179812	7.739886e-01	0.111	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.739886e-01	0.111	0	0
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	7.739886e-01	0.111	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.739886e-01	0.111	0	0
IRAK1 recruits IKK complex	R-HSA-937039	7.739886e-01	0.111	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	7.739886e-01	0.111	0	0
Regulation of IFNG signaling	R-HSA-877312	7.739886e-01	0.111	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	7.739886e-01	0.111	0	0
Interleukin-35 Signalling	R-HSA-8984722	7.739886e-01	0.111	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.739886e-01	0.111	0	0
OAS antiviral response	R-HSA-8983711	7.739886e-01	0.111	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.745264e-01	0.111	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.745264e-01	0.111	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	7.745264e-01	0.111	0	0
Degradation of DVL	R-HSA-4641258	7.748655e-01	0.111	0	0
Degradation of AXIN	R-HSA-4641257	7.748655e-01	0.111	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	7.748655e-01	0.111	0	0
Ovarian tumor domain proteases	R-HSA-5689896	7.748655e-01	0.111	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	7.776826e-01	0.109	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	7.824835e-01	0.107	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.824835e-01	0.107	0	0
G protein gated Potassium channels	R-HSA-1296059	7.824835e-01	0.107	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	7.824835e-01	0.107	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	7.824835e-01	0.107	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.824835e-01	0.107	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.824835e-01	0.107	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	7.836838e-01	0.106	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	7.858333e-01	0.105	0	0
Leishmania phagocytosis	R-HSA-9664417	7.875406e-01	0.104	0	0
Parasite infection	R-HSA-9664407	7.875406e-01	0.104	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	7.875406e-01	0.104	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	7.875889e-01	0.104	0	0
Post-translational protein phosphorylation	R-HSA-8957275	7.918625e-01	0.101	0	0
Microbial factors inhibit CASP4 activity	R-HSA-9956593	7.940594e-01	0.100	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	7.940594e-01	0.100	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	7.940594e-01	0.100	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	7.940594e-01	0.100	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	7.940594e-01	0.100	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	7.940594e-01	0.100	0	0
The phototransduction cascade	R-HSA-2514856	7.966832e-01	0.099	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	7.966832e-01	0.099	0	0
MET activates PTK2 signaling	R-HSA-8874081	7.970599e-01	0.099	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	7.970599e-01	0.099	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.970599e-01	0.099	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.970599e-01	0.099	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.970599e-01	0.099	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	7.970599e-01	0.099	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	7.997097e-01	0.097	0	0
Plasma lipoprotein clearance	R-HSA-8964043	7.997097e-01	0.097	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	8.028726e-01	0.095	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.070853e-01	0.093	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.107641e-01	0.091	0	0
Cristae formation	R-HSA-8949613	8.107641e-01	0.091	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.107641e-01	0.091	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.107641e-01	0.091	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	8.107641e-01	0.091	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.107641e-01	0.091	0	0
Diseases of Immune System	R-HSA-5260271	8.112452e-01	0.091	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.112452e-01	0.091	0	0
Interleukin-2 family signaling	R-HSA-451927	8.112452e-01	0.091	0	0
Removal of the Flap Intermediate	R-HSA-69166	8.123488e-01	0.090	0	0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	8.123488e-01	0.090	0	0
cGMP effects	R-HSA-418457	8.123488e-01	0.090	0	0
CRMPs in Sema3A signaling	R-HSA-399956	8.123488e-01	0.090	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.123488e-01	0.090	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.123488e-01	0.090	0	0
Hydrolysis of LPC	R-HSA-1483115	8.123488e-01	0.090	0	0
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	8.123488e-01	0.090	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.123488e-01	0.090	0	0
Physiological factors	R-HSA-5578768	8.123488e-01	0.090	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.123488e-01	0.090	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	8.123488e-01	0.090	0	0
Non-canonical inflammasome activation	R-HSA-9686114	8.123488e-01	0.090	0	0
HDL assembly	R-HSA-8963896	8.123488e-01	0.090	0	0
Acyl chain remodeling of CL	R-HSA-1482798	8.123488e-01	0.090	0	0
Zinc transporters	R-HSA-435354	8.123488e-01	0.090	0	0
Extracellular matrix organization	R-HSA-1474244	8.159653e-01	0.088	0	0
Amino acids regulate mTORC1	R-HSA-9639288	8.170497e-01	0.088	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.222133e-01	0.085	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	8.222133e-01	0.085	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.222133e-01	0.085	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.236360e-01	0.084	0	0
Insulin receptor recycling	R-HSA-77387	8.236360e-01	0.084	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.290149e-01	0.081	0	0
Erythropoietin activates RAS	R-HSA-9027284	8.290149e-01	0.081	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	8.290149e-01	0.081	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.290149e-01	0.081	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	8.290149e-01	0.081	0	0
Translesion synthesis by REV1	R-HSA-110312	8.290149e-01	0.081	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.290149e-01	0.081	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	8.290149e-01	0.081	0	0
Signaling by Activin	R-HSA-1502540	8.290149e-01	0.081	0	0
p38MAPK events	R-HSA-171007	8.290149e-01	0.081	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.290149e-01	0.081	0	0
Spry regulation of FGF signaling	R-HSA-1295596	8.290149e-01	0.081	0	0
DNA Damage Reversal	R-HSA-73942	8.290149e-01	0.081	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.305069e-01	0.081	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.326328e-01	0.080	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	8.326328e-01	0.080	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.326328e-01	0.080	0	0
Translation of Structural Proteins	R-HSA-9683701	8.326328e-01	0.080	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.328696e-01	0.079	0	0
Transcription of the HIV genome	R-HSA-167172	8.331036e-01	0.079	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.357153e-01	0.078	0	0
mRNA Capping	R-HSA-72086	8.357153e-01	0.078	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	8.357153e-01	0.078	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	8.357153e-01	0.078	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.357153e-01	0.078	0	0
Glucagon-type ligand receptors	R-HSA-420092	8.357153e-01	0.078	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.408923e-01	0.075	0	0
Translesion synthesis by POLI	R-HSA-5656121	8.442018e-01	0.074	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	8.442018e-01	0.074	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.442018e-01	0.074	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.442018e-01	0.074	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	8.442018e-01	0.074	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	8.442018e-01	0.074	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	8.442018e-01	0.074	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.442018e-01	0.074	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.470412e-01	0.072	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	8.470412e-01	0.072	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.470412e-01	0.072	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.470412e-01	0.072	0	0
Cellular response to chemical stress	R-HSA-9711123	8.481631e-01	0.072	0	0
Interleukin-17 signaling	R-HSA-448424	8.489644e-01	0.071	0	0
Signaling by FGFR4	R-HSA-5654743	8.519019e-01	0.070	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.519019e-01	0.070	0	0
Hedgehog 'on' state	R-HSA-5632684	8.564143e-01	0.067	0	0
Mitochondrial biogenesis	R-HSA-1592230	8.568604e-01	0.067	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.576523e-01	0.067	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.576523e-01	0.067	0	0
Cargo concentration in the ER	R-HSA-5694530	8.576523e-01	0.067	0	0
Molecules associated with elastic fibres	R-HSA-2129379	8.576523e-01	0.067	0	0
Downstream signal transduction	R-HSA-186763	8.576523e-01	0.067	0	0
Translesion synthesis by POLK	R-HSA-5655862	8.580406e-01	0.066	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	8.580406e-01	0.066	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	8.580406e-01	0.066	0	0
Fibronectin matrix formation	R-HSA-1566977	8.580406e-01	0.066	0	0
tRNA modification in the mitochondrion	R-HSA-6787450	8.580406e-01	0.066	0	0
Coenzyme A biosynthesis	R-HSA-196783	8.580406e-01	0.066	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.580406e-01	0.066	0	0
Amine ligand-binding receptors	R-HSA-375280	8.607901e-01	0.065	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.607901e-01	0.065	0	0
Interleukin-1 family signaling	R-HSA-446652	8.637644e-01	0.064	0	0
Signaling by WNT in cancer	R-HSA-4791275	8.675860e-01	0.062	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	8.675860e-01	0.062	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.675860e-01	0.062	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.678372e-01	0.062	0	0
Extension of Telomeres	R-HSA-180786	8.682623e-01	0.061	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.682623e-01	0.061	0	0
Signaling by FGFR3	R-HSA-5654741	8.692063e-01	0.061	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	8.692063e-01	0.061	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.692063e-01	0.061	0	0
Somitogenesis	R-HSA-9824272	8.692063e-01	0.061	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.706509e-01	0.060	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.706509e-01	0.060	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.706509e-01	0.060	0	0
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	8.706509e-01	0.060	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	8.706509e-01	0.060	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	8.706509e-01	0.060	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	8.706509e-01	0.060	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	8.768790e-01	0.057	0	0
Circadian clock	R-HSA-9909396	8.793311e-01	0.056	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	8.821417e-01	0.054	0	0
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	8.821417e-01	0.054	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	8.821417e-01	0.054	0	0
Apoptotic factor-mediated response	R-HSA-111471	8.821417e-01	0.054	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.833536e-01	0.054	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.833536e-01	0.054	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	8.847000e-01	0.053	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	8.855667e-01	0.053	0	0
Mitochondrial protein import	R-HSA-1268020	8.888896e-01	0.051	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.888896e-01	0.051	0	0
Signaling by PDGF	R-HSA-186797	8.888896e-01	0.051	0	0
ABC-family proteins mediated transport	R-HSA-382556	8.891692e-01	0.051	0	0
Metal ion SLC transporters	R-HSA-425410	8.918153e-01	0.050	0	0
tRNA processing	R-HSA-72306	8.922458e-01	0.050	0	0
Translesion Synthesis by POLH	R-HSA-110320	8.926123e-01	0.049	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	8.926123e-01	0.049	0	0
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	8.926123e-01	0.049	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	8.926123e-01	0.049	0	0
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	8.926123e-01	0.049	0	0
The NLRP3 inflammasome	R-HSA-844456	8.926123e-01	0.049	0	0
Signaling by NOTCH2	R-HSA-1980145	8.936832e-01	0.049	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.936832e-01	0.049	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.936832e-01	0.049	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	8.936832e-01	0.049	0	0
Translation of Structural Proteins	R-HSA-9694635	8.949171e-01	0.048	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.951088e-01	0.048	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	8.961217e-01	0.048	0	0
DNA Damage Bypass	R-HSA-73893	8.985341e-01	0.046	0	0
Chemokine receptors bind chemokines	R-HSA-380108	8.985341e-01	0.046	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.010199e-01	0.045	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.012615e-01	0.045	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.012615e-01	0.045	0	0
PERK regulates gene expression	R-HSA-381042	9.012615e-01	0.045	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.012615e-01	0.045	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.018146e-01	0.045	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.021533e-01	0.045	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.021533e-01	0.045	0	0
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.021533e-01	0.045	0	0
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.021533e-01	0.045	0	0
Acyl chain remodelling of PI	R-HSA-1482922	9.021533e-01	0.045	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.022183e-01	0.045	0	0
Triglyceride catabolism	R-HSA-163560	9.083331e-01	0.042	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.083331e-01	0.042	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.083331e-01	0.042	0	0
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.108471e-01	0.041	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.108471e-01	0.041	0	0
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.108471e-01	0.041	0	0
Signalling to RAS	R-HSA-167044	9.108471e-01	0.041	0	0
Phenylalanine metabolism	R-HSA-8964208	9.108471e-01	0.041	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	9.108471e-01	0.041	0	0
Acyl chain remodelling of PG	R-HSA-1482925	9.108471e-01	0.041	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.108546e-01	0.041	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	9.149281e-01	0.039	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.164067e-01	0.038	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.164910e-01	0.038	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	9.166344e-01	0.038	0	0
Peptide hormone metabolism	R-HSA-2980736	9.185254e-01	0.037	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.186006e-01	0.037	0	0
Serine metabolism	R-HSA-977347	9.187690e-01	0.037	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	9.187690e-01	0.037	0	0
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.187690e-01	0.037	0	0
Ribavirin ADME	R-HSA-9755088	9.187690e-01	0.037	0	0
Assembly Of The HIV Virion	R-HSA-175474	9.187690e-01	0.037	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.196606e-01	0.036	0	0
Collagen formation	R-HSA-1474290	9.196606e-01	0.036	0	0
Protein localization	R-HSA-9609507	9.197548e-01	0.036	0	0
Innate Immune System	R-HSA-168249	9.199612e-01	0.036	0	0
Elastic fibre formation	R-HSA-1566948	9.210754e-01	0.036	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.210754e-01	0.036	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.210754e-01	0.036	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.218006e-01	0.035	0	0
SLC transporter disorders	R-HSA-5619102	9.229409e-01	0.035	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.259873e-01	0.033	0	0
Biosynthesis of D-series resolvins	R-HSA-9018676	9.259873e-01	0.033	0	0
Pentose phosphate pathway	R-HSA-71336	9.268025e-01	0.033	0	0
Stimuli-sensing channels	R-HSA-2672351	9.280125e-01	0.032	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.282239e-01	0.032	0	0
Leishmania infection	R-HSA-9658195	9.282239e-01	0.032	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.305117e-01	0.031	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.321354e-01	0.031	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.321354e-01	0.031	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.325646e-01	0.030	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.325646e-01	0.030	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.325646e-01	0.030	0	0
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.325646e-01	0.030	0	0
Mitochondrial mRNA modification	R-HSA-9937008	9.325646e-01	0.030	0	0
Biosynthesis of maresins	R-HSA-9018682	9.325646e-01	0.030	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	9.348221e-01	0.029	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	9.348221e-01	0.029	0	0
Signaling by FGFR1	R-HSA-5654736	9.359280e-01	0.029	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.370991e-01	0.028	0	0
Maturation of spike protein	R-HSA-9694548	9.370991e-01	0.028	0	0
FLT3 Signaling	R-HSA-9607240	9.370991e-01	0.028	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	9.381606e-01	0.028	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	9.381606e-01	0.028	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	9.381606e-01	0.028	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.385578e-01	0.028	0	0
Complex III assembly	R-HSA-9865881	9.385578e-01	0.028	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.385578e-01	0.028	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.393916e-01	0.027	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.417169e-01	0.026	0	0
HIV Transcription Initiation	R-HSA-167161	9.417169e-01	0.026	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.417169e-01	0.026	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.417169e-01	0.026	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.417169e-01	0.026	0	0
Acyl chain remodelling of PS	R-HSA-1482801	9.440186e-01	0.025	0	0
Hyaluronan degradation	R-HSA-2160916	9.440186e-01	0.025	0	0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	9.440186e-01	0.025	0	0
Laminin interactions	R-HSA-3000157	9.440186e-01	0.025	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.457085e-01	0.024	0	0
Activation of GABAB receptors	R-HSA-991365	9.460111e-01	0.024	0	0
GABA B receptor activation	R-HSA-977444	9.460111e-01	0.024	0	0
Interleukin-1 signaling	R-HSA-9020702	9.473461e-01	0.023	0	0
Peroxisomal protein import	R-HSA-9033241	9.476646e-01	0.023	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.489944e-01	0.023	0	0
TRP channels	R-HSA-3295583	9.489944e-01	0.023	0	0
Urea cycle	R-HSA-70635	9.489944e-01	0.023	0	0
Sphingolipid catabolism	R-HSA-9845614	9.489944e-01	0.023	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	9.500028e-01	0.022	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.511096e-01	0.022	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	9.511096e-01	0.022	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	9.511096e-01	0.022	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	9.511096e-01	0.022	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	9.511096e-01	0.022	0	0
Metabolism of polyamines	R-HSA-351202	9.511096e-01	0.022	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	9.511096e-01	0.022	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	9.519651e-01	0.021	0	0
Signaling by NOTCH1	R-HSA-1980143	9.520502e-01	0.021	0	0
Toll-like Receptor Cascades	R-HSA-168898	9.524927e-01	0.021	0	0
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	9.535282e-01	0.021	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.535282e-01	0.021	0	0
Maturation of hRSV A proteins	R-HSA-9828806	9.535282e-01	0.021	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.543420e-01	0.020	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.543420e-01	0.020	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.571566e-01	0.019	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.573736e-01	0.019	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.576593e-01	0.019	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	9.576593e-01	0.019	0	0
Inflammasomes	R-HSA-622312	9.576593e-01	0.019	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	9.576593e-01	0.019	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.576593e-01	0.019	0	0
Pyroptosis	R-HSA-5620971	9.576593e-01	0.019	0	0
RSV-host interactions	R-HSA-9833110	9.576832e-01	0.019	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.595698e-01	0.018	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.595698e-01	0.018	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.602937e-01	0.018	0	0
Diseases of DNA repair	R-HSA-9675135	9.603551e-01	0.018	0	0
Thyroxine biosynthesis	R-HSA-209968	9.614233e-01	0.017	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.614233e-01	0.017	0	0
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.614233e-01	0.017	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	9.614233e-01	0.017	0	0
Regulation of gene expression in beta cells	R-HSA-210745	9.614233e-01	0.017	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	9.630375e-01	0.016	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	9.630375e-01	0.016	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.648262e-01	0.016	0	0
Cellular response to hypoxia	R-HSA-1234174	9.653740e-01	0.015	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.661445e-01	0.015	0	0
Budding and maturation of HIV virion	R-HSA-162588	9.679778e-01	0.014	0	0
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	9.679778e-01	0.014	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.680026e-01	0.014	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	9.686331e-01	0.014	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.692504e-01	0.014	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.692504e-01	0.014	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.699880e-01	0.013	0	0
DAG1 glycosylations	R-HSA-8931838	9.708251e-01	0.013	0	0
Formation of the cornified envelope	R-HSA-6809371	9.717440e-01	0.012	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.719429e-01	0.012	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.731977e-01	0.012	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	9.734193e-01	0.012	0	0
Regulation of necroptotic cell death	R-HSA-5675482	9.734193e-01	0.012	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.734193e-01	0.012	0	0
Recycling of bile acids and salts	R-HSA-159418	9.734193e-01	0.012	0	0
Post-translational protein modification	R-HSA-597592	9.738884e-01	0.011	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.745365e-01	0.011	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.757830e-01	0.011	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.757830e-01	0.011	0	0
ECM proteoglycans	R-HSA-3000178	9.773187e-01	0.010	0	0
Metabolism of cofactors	R-HSA-8978934	9.773187e-01	0.010	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	9.779366e-01	0.010	0	0
Hyaluronan metabolism	R-HSA-2142845	9.779366e-01	0.010	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.779366e-01	0.010	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.798989e-01	0.009	0	0
G alpha (i) signalling events	R-HSA-418594	9.801988e-01	0.009	1	0
Paracetamol ADME	R-HSA-9753281	9.804795e-01	0.009	0	0
RUNX2 regulates bone development	R-HSA-8941326	9.816867e-01	0.008	0	0
NCAM1 interactions	R-HSA-419037	9.833156e-01	0.007	0	0
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.833156e-01	0.007	0	0
Lysine catabolism	R-HSA-71064	9.833156e-01	0.007	0	0
Collagen chain trimerization	R-HSA-8948216	9.833156e-01	0.007	0	0
Metabolism of folate and pterines	R-HSA-196757	9.833156e-01	0.007	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.836802e-01	0.007	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.836802e-01	0.007	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.846413e-01	0.007	0	0
tRNA processing in the mitochondrion	R-HSA-6785470	9.847997e-01	0.007	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.847997e-01	0.007	0	0
Triglyceride metabolism	R-HSA-8979227	9.858261e-01	0.006	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.860739e-01	0.006	0	0
RAS processing	R-HSA-9648002	9.861519e-01	0.006	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.861519e-01	0.006	0	0
ABC transporter disorders	R-HSA-5619084	9.863062e-01	0.006	0	0
GABA receptor activation	R-HSA-977443	9.869218e-01	0.006	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.869630e-01	0.006	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.873838e-01	0.006	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.873838e-01	0.006	0	0
Collagen degradation	R-HSA-1442490	9.879348e-01	0.005	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.881872e-01	0.005	0	0
G alpha (q) signalling events	R-HSA-416476	9.887057e-01	0.005	0	0
Intra-Golgi traffic	R-HSA-6811438	9.895289e-01	0.005	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.904606e-01	0.004	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.913606e-01	0.004	0	0
G alpha (s) signalling events	R-HSA-418555	9.916287e-01	0.004	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.919566e-01	0.004	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.920828e-01	0.003	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.924868e-01	0.003	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.924868e-01	0.003	0	0
Kidney development	R-HSA-9830369	9.925865e-01	0.003	0	0
PI Metabolism	R-HSA-1483255	9.929808e-01	0.003	0	0
Regulated Necrosis	R-HSA-5218859	9.931680e-01	0.003	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	9.933476e-01	0.003	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.934293e-01	0.003	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.934293e-01	0.003	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.934293e-01	0.003	0	0
Pyruvate metabolism	R-HSA-70268	9.934571e-01	0.003	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.936300e-01	0.003	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	9.942242e-01	0.003	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.945469e-01	0.002	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.946572e-01	0.002	0	0
Neurotransmitter release cycle	R-HSA-112310	9.947762e-01	0.002	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.947762e-01	0.002	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.950790e-01	0.002	0	0
Aspirin ADME	R-HSA-9749641	9.954680e-01	0.002	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.954746e-01	0.002	0	0
Complex IV assembly	R-HSA-9864848	9.958774e-01	0.002	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.961576e-01	0.002	0	0
Iron uptake and transport	R-HSA-917937	9.961576e-01	0.002	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.961576e-01	0.002	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.966169e-01	0.001	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.967438e-01	0.001	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.970030e-01	0.001	0	0
Interleukin-10 signaling	R-HSA-6783783	9.970030e-01	0.001	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.971547e-01	0.001	0	0
Potassium Channels	R-HSA-1296071	9.971547e-01	0.001	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.973967e-01	0.001	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.974138e-01	0.001	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.975708e-01	0.001	0	0
Synthesis of PA	R-HSA-1483166	9.976441e-01	0.001	0	0
Dectin-2 family	R-HSA-5621480	9.976441e-01	0.001	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.977443e-01	0.001	0	0
Regulation of beta-cell development	R-HSA-186712	9.980451e-01	0.001	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.980451e-01	0.001	0	0
RAB geranylgeranylation	R-HSA-8873719	9.982192e-01	0.001	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.985419e-01	0.001	0	0
Digestion and absorption	R-HSA-8963743	9.986540e-01	0.001	0	0
PPARA activates gene expression	R-HSA-1989781	9.987403e-01	0.001	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.987739e-01	0.001	0	0
Neddylation	R-HSA-8951664	9.988900e-01	0.000	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.988982e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.989119e-01	0.000	1	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.989406e-01	0.000	0	0
Nicotinate metabolism	R-HSA-196807	9.990733e-01	0.000	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.990733e-01	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.991559e-01	0.000	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.992406e-01	0.000	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.992997e-01	0.000	0	0
Glycosphingolipid catabolism	R-HSA-9840310	9.992997e-01	0.000	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.992997e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.994707e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.994870e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.995254e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.995672e-01	0.000	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	9.996682e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.997175e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.997493e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.998106e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.998450e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.998466e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.998853e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999322e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999438e-01	0.000	0	0
Drug ADME	R-HSA-9748784	9.999501e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.999533e-01	0.000	1	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999591e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.999641e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999783e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	9.999816e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999874e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999892e-01	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	9.999896e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999912e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999919e-01	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	9.999972e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999972e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999977e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999988e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999989e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999989e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999989e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999993e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999996e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.999996e-01	0.000	1	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.999997e-01	0.000	0	0
Complement cascade	R-HSA-166658	9.999998e-01	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999999e-01	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0