NUAK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A6NKT7	S980	Sugiyama	RGPD3 RGP3	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
A6NMY6	T163	Sugiyama	ANXA2P2 ANX2L2 ANX2P2 LPC2B	INRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDG
O14715	S979	Sugiyama	RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O14974	S445	Sugiyama	PPP1R12A MBS MYPT1	EEERKDEsPATWRLGLRKtGsyGALAEItASKEGQKEKDTA
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15226	S618	Sugiyama	NKRF ITBA4 NRF	VNKIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQ
O15446	S64	Sugiyama	POLR1G ASE1 CAST CD3EAP PAF49	LIQAPADFAPECFNGRHVPLsGsQIVKGKLAGKRHRyRVLS
O43399	S21	Sugiyama	TPD52L2	MDsAGQDINLNsPNKGLLsDsMtDVPVDTGVAARtPAVEGL
O43823	S323	Sugiyama	AKAP8 AKAP95	RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O94888	S280	Sugiyama	UBXN7 KIAA0794 UBXD7	EHGQLDGLsssPPKKCARsEsLIDAsEDsQLEAAIRASLQE
O95456	S180	Sugiyama	PSMG1 C21LRP DSCR2 PAC1	KNMQITILTCRHVTDYKTSEsTGsLPsPFLRALKTQNFKDS
O95678	S162	Sugiyama	KRT75 K6HF KB18	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95757	S587	Sugiyama	HSPA4L APG1 HSPH3 OSP94	RLNQTLKKGKVKsIDLPIQssLCRQLGQDLLNsyIENEGKM
O95835	S464	GPS6\|SIGNOR\|EPSD\|PSP\|Sugiyama	LATS1 WARTS	SPSSGHEIPTWQPNIPVRsNsFNNPLGNRASHSANSQPSAT
P00338	S105	Sugiyama	LDHA PIG19	VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P02538	S176	Sugiyama	KRT6A K6A KRT6D	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04040	S515	Sugiyama	CAT	ALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL________
P04040	S517	Sugiyama	CAT	LDKYNAEKPKNAIHtFVQsGsHLAAREKANL__________
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04083	S173	Sugiyama	ANXA1 ANX1 LPC1	NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04259	S176	Sugiyama	KRT6B K6B KRTL1	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	S321	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE______
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05455	S94	Sugiyama	SSB	KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05787	S104	Sugiyama	KRT8 CYK8	IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733	S27	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P07195	S106	Sugiyama	LDHB	VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07355	T163	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	INRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDG
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	S53	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900	T317	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	T309	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08729	S104	Sugiyama	KRT7 SCL	LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P0DJD0	S964	Sugiyama	RGPD1 RANBP2L6 RGP1	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10619	S51	Sugiyama	CTSA PPGB	DQDEIQRLPGLAKQPSFRQYsGYLKGSGSKHLHYWFVESQK
P11142	T64	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11279	S141	Sugiyama	LAMP1	NLSDTHLFPNASSKEIKtVEsITDIRADIDKKYRCVSGTQV
P11532	S3623	Sugiyama	DMD	EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P12035	S211	Sugiyama	KRT3	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639	S38	Sugiyama	EEF2 EF2	NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13647	S181	Sugiyama	KRT5	IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13667	S470	Sugiyama	PDIA4 ERP70 ERP72	FAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAMEP
P13798	S187	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	EKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQFV
P14618	S202	Sugiyama	PKM OIP3 PK2 PK3 PKM2	SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14625	S172	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI
P14625	S514	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625	S551	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKEKQDKIyFMAGsSRKEAEssPFVERLLKKGyEVIyLTEP
P14625	S64	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625	T171	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P15880	T232	Sugiyama	RPS2 RPS4	KLLMMAGIDDCytsARGCtAtLGNFAKATFDAISKTysyLt
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P18615	S135	Sugiyama	NELFE RD RDBP	sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18754	S85	Sugiyama	RCC1 CHC1	IPEDVVQAEAGGMHTVCLSKsGQVysFGCNDEGALGRDtsV
P21108	S11	Sugiyama	PRPS1L1 PRPS3 PRPSL	__________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P22314	S46	Sugiyama	UBA1 A1S9T UBE1	AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23396	T242	Sugiyama	RPS3 OK/SW-cl.26	PIsEQKGGKPEPPAMPQPVPtA___________________
P23528	S41	Sugiyama	CFL1 CFL	RKsstPEEVKKRKKAVLFCLsEDKKNIILEEGKEILVGDVG
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P26232	S667	Sugiyama	CTNNA2 CAPR	YDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEEKAKIAEQV
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T107	Sugiyama	RPL13 BBC1 OK/SW-cl.46	HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26641	S286	Sugiyama	EEF1G EF1G PRO1608	CEQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVA
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P28838	S194	Sugiyama	LAP3 LAPEP PEPS	SAKLyGsGDQEAWQKGVLFAsGQNLARQLMETPANEMTPtR
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30101	T485	Sugiyama	PDIA3 ERP57 ERP60 GRP58	KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30622	S195	Sugiyama	CLIP1 CYLN1 RSN	AAKEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELKIG
P31153	S247	Sugiyama	MAT2A AMS2 MATA2	IKAVVPAKyLDEDtIyHLQPsGRFVIGGPQGDAGLtGRKII
P31943	S23	Sugiyama	HNRNPH1 HNRPH HNRPH1	LGTEGGEGFVVKVRGLPWsCsADEVQRFFSDCKIQNGAQGI
P31943	S269	Sugiyama	HNRNPH1 HNRPH HNRPH1	YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQsttGH
P32119	T142	Sugiyama	PRDX2 NKEFB TDPX1	EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33992	S423	Sugiyama	MCM5 CDC46	ytsGKGSSAAGLtAsVMRDPssRNFIMEGGAMVLADGGVVC
P33992	S424	Sugiyama	MCM5 CDC46	tsGKGSSAAGLtAsVMRDPssRNFIMEGGAMVLADGGVVCI
P35221	S668	Sugiyama	CTNNA1	FDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEQKAKIAEQV
P35579	S1304	Sugiyama	MYH9	NVtGLLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQK
P35579	T1764	Sugiyama	MYH9	NtELINDRLKKANLQIDQINtDLNLERSHAQKNENARQQLE
P35580	S1939	Sugiyama	MYH10	REVSTLKNRLRRGGPIsFsssRSGRRQLHLEGAsLELsDDD
P35613	S229	Sugiyama	BSG UNQ6505/PRO21383	PMGTANIQLHGPPRVKAVKssEHINEGEtAMLVCKSEsVPP
P35613	S279	Sugiyama	BSG UNQ6505/PRO21383	TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P35908	S191	Sugiyama	KRT2 KRT2A KRT2E	IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646	T398	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P38646	T86	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40939	T393	Sugiyama	HADHA HADH	GAGIAQVSVDKGLKTILKDAtLtALDRGQQQVFKGLNDKVK
P41091	T21	Sugiyama	EIF2S3 EIF2G	MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P41252	S1047	Sugiyama	IARS1 IARS	ESHTEFIFTTIKAPLKPYPVsPsDKVLIQEKTQLKGSELEI
P42677	S78	Sugiyama	RPS27 MPS1	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490	S472	Sugiyama	NAMPT PBEF PBEF1	EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777	S176	Sugiyama	RPL5 MSTP030	GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46778	T29	Sugiyama	RPL21	RGTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQ
P46940	S343	Sugiyama	IQGAP1 KIAA0051	ALFRALQsPALGLRGLQQQNsDWYLKQLLSDKQQKRQsGQT
P48668	S176	Sugiyama	KRT6C KRT6E	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P49321	S659	Sugiyama	NASP	IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49790	S607	Sugiyama	NUP153	KtPPEDCEGPFRPAEILKEGsVLDILKsPGFAsPKIDSVAA
P49792	S1955	Sugiyama	RANBP2 NUP358	GVIFGQTSSTFTFADLAKstsGEGFQFGKKDPNFKGFSGAG
P50395	S396	Sugiyama	GDI2 RABGDIB	IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50402	T30	Sugiyama	EMD EDMD STA	tELttLLRRyNIPHGPVVGstRRLyEKKIFEyEtQRRRLsP
P50991	T50	Sugiyama	CCT4 CCTD SRB	PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P52298	S13	Sugiyama	NCBP2 CBP20 PIG55	________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53992	Y379	Sugiyama	SEC24C KIAA0079	TNFLVKDQGNASPRYIRCTsyNIPCTSDMAKQAQVPLAAVI
P54252	S260	Sugiyama	ATXN3 ATX3 MJD MJD1 SCA3	IDMEDEEADLRRAIQLsMQGssRNIsQDMtQtsGTNLTSEE
P55010	S10	Sugiyama	EIF5	___________MSVNVNRsVsDQFyRyKMPRLIAKVEGKGN
P55795	S269	Sugiyama	HNRNPH2 FTP3 HNRPH2	YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQstTGH
P60174	T217	Sugiyama	TPI1 TPI	VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60891	S11	Sugiyama	PRPS1	__________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P61313	S97	Sugiyama	RPL15 EC45 TCBAP0781	KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61916	T44	Sugiyama	NPC2 HE1	FKDCGsVDGVIKEVNVsPCPtQPCQLSKGQSYSVNVTFTSN
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	S74	Sugiyama	RPS11	tyIDKKCPFTGNVsIRGRILsGVVTKMKMQRTIVIRRDYLH
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62899	T26	Sugiyama	RPL31	KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731	S7	Sugiyama	RPL24	______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731	T83	Sugiyama	RPL24	QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00613	S375	Sugiyama	HSF1 HSTF1	TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105	S168	Sugiyama	SET	ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01546	S196	Sugiyama	KRT76 KRT2B KRT2P	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q04637	S1238	Sugiyama	EIF4G1 EIF4F EIF4G EIF4GI	RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q06210	S261	Sugiyama	GFPT1 GFAT GFPT	GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06830	T143	Sugiyama	PRDX1 PAGA PAGB TDPX2	EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q08AD1	S464	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q09028	S146	Sugiyama	RBBP4 RBAP48	EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q13243	S153	Sugiyama	SRSF5 HRS SFRS5 SRP40	EVTFADAHRPKLNEGVVEFAsYGDLKNAIEKLSGKEINGRK
Q13263	S473	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13283	S362	Sugiyama	G3BP1 G3BP	LFIGNLPHEVDKSELKDFFQsyGNVVELRINsGGKLPNFGF
Q13573	S182	Sugiyama	SNW1 SKIIP SKIP	AMPVRAADKLAPAQyIRytPsQQGVAFNsGAKQRVIRMVEM
Q13765	S186	Sugiyama	NACA HSD48	sEEEEVDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDI
Q14152	S1028	Sugiyama	EIF3A EIF3S10 KIAA0139	NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152	S492	Sugiyama	EIF3A EIF3S10 KIAA0139	VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568	S53	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14CN4	S138	Sugiyama	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15021	S1333	Sugiyama	NCAPD2 CAPD2 CNAP1 KIAA0159	APsAKKPSTGSRyQPLAstAsDNDFVtPEPRRTTRRHPNTQ
Q15084	S377	Sugiyama	PDIA6 ERP5 P5 TXNDC7	PAMAAINARKMKFALLKGsFsEQGINEFLRELsFGRGstAP
Q15172	S472	Sugiyama	PPP2R5A	EELWKKLEELKLKKALEKQNsAyNMHSILSNTSAE______
Q15185	S113	Sugiyama	PTGES3 P23 TEBP	RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15293	S80	Sugiyama	RCN1 RCN	HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q15293	T71	Sugiyama	RCN1 RCN	EDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRI
Q15642	S296	Sugiyama	TRIP10 CIP4 STOT STP	FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q16576	S145	Sugiyama	RBBP7 RBAP46	EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16658	S237	Sugiyama	FSCN1 FAN1 HSN SNL	RsGKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALE
Q2VIR3	T21	Sugiyama	EIF2S3B	MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q3KQU3	S366	Sugiyama	MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464	GPQPDRTHPSAAVPVCPRsAsAsPLtPCSVTRSVHRCAPAG
Q3SY84	S143	Sugiyama	KRT71 K6IRS1 KB34 KRT6IRS1	IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q5JSH3	S565	Sugiyama	WDR44 RPH11	DYFNNMRMKYNtEGRVsPsPsQEsLsssKsDTDtGVCsGtD
Q5SYE7	S1495	Sugiyama	NHSL1 C6orf63 KIAA1357	KNRRAQEEWAKNEGLMPRsLsFsGPRYGRSRTPPSAASSRY
Q5T5C0	S692	Sugiyama	STXBP5 LLGL3	YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q5XKE5	S155	Sugiyama	KRT79 K6L KB38 KRT6L	IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6FI81	S305	Sugiyama	CIAPIN1 CUA001 PRO0915	CAsCPyLGMPAFKPGEKVLLsDsNLHDA_____________
Q6GYQ0	T798	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6P996	S722	Sugiyama	PDXDC1 KIAA0251	PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PID6	S19	Sugiyama	TTC33	__MASFGWKRKIGEKVSKVTsQQFEAEAADEKDVVDNDEGN
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71UM5	S78	Sugiyama	RPS27L	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7KZ85	S1525	Sugiyama	SUPT6H KIAA0162 SPT6H	NGLFRWFKDHYQDPVPGItPssssRtRtPAsINAtPANINL
Q7LBC6	S766	Sugiyama	KDM3B C5orf7 JHDM2B JMJD1B KIAA1082	tEERPtVGPGQQDNPLLKTFsNVFGRHsGGFLssPADFsQE
Q7RTS7	S153	Sugiyama	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z3J3	S980	Sugiyama	RGPD4 RGP4	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
Q7Z401	S1511	Sugiyama	DENND4A IRLB MYCPBP	LNIEIRDLRRPGRYFLKssPstENMHFPSSISSQTRQSCIs
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z794	S177	Sugiyama	KRT77 KRT1B	IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86UP3	S314	Sugiyama	ZFHX4	VTHAVHDHRMTLNDEEQKLLsNKCVsAIIQGIGKDKEPLIS
Q86UP3	S319	Sugiyama	ZFHX4	HDHRMTLNDEEQKLLsNKCVsAIIQGIGKDKEPLISFLEPK
Q86V81	S239	Sugiyama	ALYREF ALY BEF THOC4	tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86Y46	S145	Sugiyama	KRT73 K6IRS3 KB36 KRT6IRS3	IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8	S904	Sugiyama	CHERP DAN26 SCAF6	KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IYB3	S240	Sugiyama	SRRM1 SRM160	tPELPEPsVKVKEPsVQEAtstsDILKVPKPEPIPEPKEPs
Q8N6T3	S345	Sugiyama	ARFGAP1 ARF1GAP	DQSFWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWE
Q8N8S7	S125	Sugiyama	ENAH MENA	MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NEZ2	S326	Sugiyama	VPS37A HCRP1	QMKSTFEKKMQRQHELSEsCsASALQARLKVAAHEAEEESD
Q8WUF5	S102	Sugiyama	PPP1R13L IASPP NKIP1 PPP1R13BL RAI	RGsPRKAATDGADtPFGRsEsAPtLHPysPLsPKGRPssPR
Q8WWM7	S273	Sugiyama	ATXN2L A2D A2LG A2LP A2RP	PNEMFKFNEENyGVKTtyDssLssytVPLEKDNsEEFRQRE
Q92609	S541	Sugiyama	TBC1D5 KIAA0210	EsMPVQLNKGLSSKNIsssPsVEsLPGGREFtGsPPssAtK
Q92614	S72	Sugiyama	MYO18A CD245 KIAA0216 MYSPDZ TIAF1	sKRESKTRLEISNPIPIKVAsGsDLHLTDIDsDsNRGSVIL
Q92625	S663	Sugiyama	ANKS1A ANKS1 KIAA0229 ODIN	sRsEsLsNCsIGKKRLEKsPsFAsEWDEIEKIMssIGEGID
Q96IZ0	S259	Sugiyama	PAWR PAR4	SRYsRTDRSGFPRYNRDANVsGtLVSSstLEKKIEDLEKEV
Q96L92	S51	Sugiyama	SNX27 KIAA0488 My014	AGNGGGGGGGPRVVRIVKsEsGYGFNVRGQVsEGGQLRSIN
Q96N67	S1432	Sugiyama	DOCK7 KIAA1771	RRSRGQLGTYTIAsPPERsPsGsAFGsQENLRWRKDMTHWR
Q96PK6	S520	Sugiyama	RBM14 SIP	AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q96PK6	S521	Sugiyama	RBM14 SIP	AAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASYR
Q96RR4	S105	Sugiyama	CAMKK2 CAMKKB KIAA0787	tsGSQARPHLSGRKLsLQERsQGGLAAGGsLDMNGRCICPs
Q96RR4	S114	Sugiyama	CAMKK2 CAMKKB KIAA0787	LSGRKLsLQERsQGGLAAGGsLDMNGRCICPsLPysPVssP
Q99614	S187	Sugiyama	TTC1 TPR1	KQDKKEMAINDCSKAIQLNPsyIRAILRRAELYEKTDKLDE
Q99618	S94	Sugiyama	CDCA3 C8 GRCC8 TOME1	ARtPMKTSsGDPPsPLVKQLsEVFETEDSKSNLPPEPVLPP
Q99666	S979	Sugiyama	RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
Q99700	T811	Sugiyama	ATXN2 ATX2 SCA2 TNRC13	RKQIDDLKKFKNDFRLQPSStSESMDQLLNKNREGEKSRDL
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BT78	S18	Sugiyama	COPS4 CSN4	___MAAAVRQDLAQLMNSsGsHKDLAGKYRQILEKAIQLSG
Q9BUJ2	T534	Sugiyama	HNRNPUL1 E1BAP5 HNRPUL1	QRRKMRPFEGFQRKAIVICPtDEDLKDRTIKRTDEEGKDVP
Q9BUK0	S18	Sugiyama	CHCHD7	___MPSVTQRLRDPDINPCLsESDASTRCLDENNYDRERCS
Q9C0C2	S437	Sugiyama	TNKS1BP1 KIAA1741 TAB182	HLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQGsQ
Q9GZR7	S828	Sugiyama	DDX24	KYPTQSGKPPLLVSAPsKSEsALSCLsKQKKKKTKKPKEPQ
Q9H093	S325	Sugiyama	NUAK2 OMPHK2 SNARK	WGYATRVGEQEAPHEGGHPGsDsARAsMADWLRRSSRPLLE
Q9H093	S327	Sugiyama	NUAK2 OMPHK2 SNARK	YATRVGEQEAPHEGGHPGsDsARAsMADWLRRSSRPLLENG
Q9H093	S331	Sugiyama	NUAK2 OMPHK2 SNARK	VGEQEAPHEGGHPGsDsARAsMADWLRRSSRPLLENGAKVC
Q9H093	S386	Sugiyama	NUAK2 OMPHK2 SNARK	PGLERQHSLKKSRKENDMAQsLHsDtADDTAHRPGKSNLKL
Q9H093	S389	Sugiyama	NUAK2 OMPHK2 SNARK	ERQHSLKKSRKENDMAQsLHsDtADDTAHRPGKSNLKLPKG
Q9H093	S492	Sugiyama	NUAK2 OMPHK2 SNARK	LDAGDVFVSGDPKEQKPPQAsGLLLHRKGILKLNGKFSQTA
Q9H093	S573	Sugiyama	NUAK2 OMPHK2 SNARK	SFDQLDLPERLPEPPLRGCVsVDNLtGLEEPPsEGPGsCLR
Q9H093	S585	Sugiyama	NUAK2 OMPHK2 SNARK	EPPLRGCVsVDNLtGLEEPPsEGPGsCLRRWRQDPLGDSCF
Q9H093	S590	Sugiyama	NUAK2 OMPHK2 SNARK	GCVsVDNLtGLEEPPsEGPGsCLRRWRQDPLGDSCFSLTDC
Q9H093	T365	Sugiyama	NUAK2 OMPHK2 SNARK	ENGAKVCSFFKQHAPGGGSTtPGLERQHSLKKSRKENDMAQ
Q9H093	T391	Sugiyama	NUAK2 OMPHK2 SNARK	QHSLKKSRKENDMAQsLHsDtADDTAHRPGKSNLKLPKGIL
Q9H093	T578	Sugiyama	NUAK2 OMPHK2 SNARK	DLPERLPEPPLRGCVsVDNLtGLEEPPsEGPGsCLRRWRQD
Q9H093	T58	Sugiyama	NUAK2 OMPHK2 SNARK	QAVKRHHHKHNLRHRYEFLEtLGKGTYGKVKKARESSGRLV
Q9H0H5	S257	Sugiyama	RACGAP1 KIAA1478 MGCRACGAP	ETVPYWtRSRRKtGtLQPWNsDstLNSRQLEPRTETDsVGt
Q9H788	S315	Sugiyama	SH2D4A PPP1R38 SH2A	LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9HAU0	S410	Sugiyama	PLEKHA5 KIAA1686 PEPP2	NRPNTGPLytEADRVIQRtNsMQQLEQWIKIQKGRGHEEET
Q9HCN8	S40	Sugiyama	SDF2L1 UNQ1941/PRO4424	ALLVPGGGAAKTGAELVTCGsVLKLLNTHHRVRLHSHDIKY
Q9NP61	S367	Sugiyama	ARFGAP3 ARFGAP1	DsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKDT
Q9NSB2	S178	Sugiyama	KRT84 KRTHB4	AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9P1Y5	S431	Sugiyama	CAMSAP3 KIAA1543	FGLDSDVDVVMGDPVLLRsVssDsLGPPRPAPARTPtQPPP
Q9UGV2	S331	Sugiyama	NDRG3	QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UKV8	S387	Sugiyama	AGO2 EIF2C2	ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9ULD2	S1203	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9UNZ2	S176	Sugiyama	NSFL1C UBXN2C	RLGAAPEEEsAyVAGEKRQHssQDVHVVLKLWKsGFsLDNG
Q9UPQ0	S201	Sugiyama	LIMCH1 KIAA1102	DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQ35	S1537	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sGsEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERs
Q9UQ35	S1539	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35	S1542	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDss
Q9Y2B0	S55	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDELEWEIAQVDPKKTIQMGsFRINPDGsQsVVEVPyARsE
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y580	S136	Sugiyama	RBM7	RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Q9Y5K5	S131	Sugiyama	UCHL5 UCH37 AD-019 CGI-70	LSEFKEFSQSFDAAMKGLALsNsDVIRQVHNSFARQQMFEF
Q9Y617	S226	Sugiyama	PSAT1 PSA	GVTVVIVRDDLLGFALRECPsVLEyKVQAGNSSLYNTPPCF

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Axon guidance	R-HSA-422475	1.096245e-11	10.960
Nervous system development	R-HSA-9675108	2.098434e-10	9.678
Cell Cycle	R-HSA-1640170	2.125851e-09	8.672
Signal Transduction	R-HSA-162582	7.226263e-09	8.141
Apoptotic execution phase	R-HSA-75153	1.609594e-08	7.793
Cell Cycle, Mitotic	R-HSA-69278	2.307357e-08	7.637
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.790750e-08	7.554
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.820068e-07	6.740
M Phase	R-HSA-68886	9.695261e-07	6.013
Metalloprotease DUBs	R-HSA-5689901	3.116806e-06	5.506
Signaling by ROBO receptors	R-HSA-376176	3.296563e-06	5.482
Mitotic Anaphase	R-HSA-68882	5.091090e-06	5.293
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.765554e-06	5.239
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.115864e-05	4.952
Apoptosis	R-HSA-109581	1.335144e-05	4.874
Cell Cycle Checkpoints	R-HSA-69620	2.707227e-05	4.567
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.929429e-05	4.533
Separation of Sister Chromatids	R-HSA-2467813	3.520634e-05	4.453
Intracellular signaling by second messengers	R-HSA-9006925	4.000147e-05	4.398
Mitotic G2-G2/M phases	R-HSA-453274	5.436888e-05	4.265
VEGFA-VEGFR2 Pathway	R-HSA-4420097	6.268217e-05	4.203
Programmed Cell Death	R-HSA-5357801	6.504009e-05	4.187
G alpha (12/13) signalling events	R-HSA-416482	7.827946e-05	4.106
Signaling by ERBB2	R-HSA-1227986	8.882791e-05	4.051
Mitotic Prometaphase	R-HSA-68877	9.648244e-05	4.016
NRAGE signals death through JNK	R-HSA-193648	9.970243e-05	4.001
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.049854e-04	3.979
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.138176e-04	3.944
Death Receptor Signaling	R-HSA-73887	1.472331e-04	3.832
G2/M Transition	R-HSA-69275	1.511202e-04	3.821
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.609406e-04	3.793
Post NMDA receptor activation events	R-HSA-438064	1.933283e-04	3.714
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.296143e-04	3.639
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.602303e-04	3.585
Signaling by VEGF	R-HSA-194138	2.927712e-04	3.533
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.102467e-04	3.508
Neurodegenerative Diseases	R-HSA-8863678	3.102467e-04	3.508
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.044488e-04	3.516
RET signaling	R-HSA-8853659	3.614293e-04	3.442
Regulation of TP53 Degradation	R-HSA-6804757	3.614293e-04	3.442
Integrin signaling	R-HSA-354192	3.884306e-04	3.411
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.867422e-04	3.413
Mitotic Spindle Checkpoint	R-HSA-69618	4.090662e-04	3.388
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	5.541585e-04	3.256
Chromatin modifying enzymes	R-HSA-3247509	6.563588e-04	3.183
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	6.891102e-04	3.162
Amplification of signal from the kinetochores	R-HSA-141424	6.891102e-04	3.162
ChREBP activates metabolic gene expression	R-HSA-163765	7.752652e-04	3.111
mRNA 3'-end processing	R-HSA-72187	7.554106e-04	3.122
PIP3 activates AKT signaling	R-HSA-1257604	7.681453e-04	3.115
p75 NTR receptor-mediated signalling	R-HSA-193704	7.379615e-04	3.132
TBC/RABGAPs	R-HSA-8854214	8.095308e-04	3.092
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	8.831006e-04	3.054
Transcriptional regulation by RUNX1	R-HSA-8878171	9.054192e-04	3.043
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	8.831006e-04	3.054
Chromatin organization	R-HSA-4839726	8.686107e-04	3.061
Aggrephagy	R-HSA-9646399	9.157605e-04	3.038
Regulation of TP53 Activity	R-HSA-5633007	9.930808e-04	3.003
Cellular responses to stimuli	R-HSA-8953897	9.802165e-04	3.009
Signaling by Hippo	R-HSA-2028269	1.034610e-03	2.985
Transcriptional Regulation by TP53	R-HSA-3700989	1.102941e-03	2.957
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.283535e-03	2.892
Cellular responses to stress	R-HSA-2262752	1.243685e-03	2.905
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.298080e-03	2.887
Chaperone Mediated Autophagy	R-HSA-9613829	1.432375e-03	2.844
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.446988e-03	2.840
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.502966e-03	2.823
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.551719e-03	2.809
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	1.590745e-03	2.798
TRP channels	R-HSA-3295583	1.748168e-03	2.757
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.785996e-03	2.748
Nuclear Envelope Breakdown	R-HSA-2980766	1.858271e-03	2.731
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.933857e-03	2.714
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.957152e-03	2.708
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.056468e-03	2.687
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.169534e-03	2.664
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	2.258681e-03	2.646
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.373705e-03	2.625
Signaling by Interleukins	R-HSA-449147	2.268144e-03	2.644
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.496648e-03	2.603
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.599401e-03	2.585
Membrane Trafficking	R-HSA-199991	2.684790e-03	2.571
FLT3 signaling by CBL mutants	R-HSA-9706377	2.909941e-03	2.536
FLT3 Signaling	R-HSA-9607240	2.902108e-03	2.537
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.969905e-03	2.527
mRNA Splicing - Major Pathway	R-HSA-72163	2.992529e-03	2.524
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.383185e-03	2.471
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.417245e-03	2.466
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.417245e-03	2.466
RNA Polymerase II Transcription Termination	R-HSA-73856	3.522966e-03	2.453
ROBO receptors bind AKAP5	R-HSA-9010642	4.288399e-03	2.368
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.288399e-03	2.368
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.358414e-03	2.361
Diseases of programmed cell death	R-HSA-9645723	4.358414e-03	2.361
Eukaryotic Translation Elongation	R-HSA-156842	4.129664e-03	2.384
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	4.201287e-03	2.377
L1CAM interactions	R-HSA-373760	4.244913e-03	2.372
Downregulation of ERBB2 signaling	R-HSA-8863795	4.439511e-03	2.353
mRNA Splicing	R-HSA-72172	4.498794e-03	2.347
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.890706e-03	2.311
Activation of RAC1	R-HSA-428540	4.890706e-03	2.311
Regulation of TP53 Activity through Methylation	R-HSA-6804760	4.781324e-03	2.320
Polo-like kinase mediated events	R-HSA-156711	4.781324e-03	2.320
NOD1/2 Signaling Pathway	R-HSA-168638	4.734328e-03	2.325
Semaphorin interactions	R-HSA-373755	4.736183e-03	2.325
Transcriptional Regulation by E2F6	R-HSA-8953750	4.913283e-03	2.309
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	4.982825e-03	2.303
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.042631e-03	2.297
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.084244e-03	2.294
Germ layer formation at gastrulation	R-HSA-9754189	6.237877e-03	2.205
Regulation of signaling by CBL	R-HSA-912631	6.237877e-03	2.205
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	5.658659e-03	2.247
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	6.279781e-03	2.202
Rap1 signalling	R-HSA-392517	6.237877e-03	2.205
Hedgehog 'off' state	R-HSA-5610787	6.147363e-03	2.211
Gene expression (Transcription)	R-HSA-74160	6.164788e-03	2.210
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	6.461312e-03	2.190
Transcriptional Regulation by MECP2	R-HSA-8986944	6.228302e-03	2.206
Glycolysis	R-HSA-70171	6.147363e-03	2.211
Kinesins	R-HSA-983189	6.510397e-03	2.186
RNA Polymerase II Transcription	R-HSA-73857	6.631569e-03	2.178
G0 and Early G1	R-HSA-1538133	6.683102e-03	2.175
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	6.854943e-03	2.164
Platelet Aggregation (Plug Formation)	R-HSA-76009	6.978130e-03	2.156
DAG and IP3 signaling	R-HSA-1489509	6.978130e-03	2.156
VEGFR2 mediated vascular permeability	R-HSA-5218920	6.997695e-03	2.155
Cellular response to heat stress	R-HSA-3371556	7.023218e-03	2.153
TNF signaling	R-HSA-75893	7.766456e-03	2.110
Deubiquitination	R-HSA-5688426	8.114072e-03	2.091
Nephrin family interactions	R-HSA-373753	8.013679e-03	2.096
Regulation of NFE2L2 gene expression	R-HSA-9818749	8.214041e-03	2.085
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	8.214041e-03	2.085
Breakdown of the nuclear lamina	R-HSA-352238	8.251239e-03	2.083
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.275998e-03	2.082
Signaling by NTRKs	R-HSA-166520	8.278143e-03	2.082
Rab regulation of trafficking	R-HSA-9007101	8.319256e-03	2.080
Peptide chain elongation	R-HSA-156902	8.324814e-03	2.080
Apoptosis induced DNA fragmentation	R-HSA-140342	9.339885e-03	2.030
Josephin domain DUBs	R-HSA-5689877	9.339885e-03	2.030
Late endosomal microautophagy	R-HSA-9615710	9.458965e-03	2.024
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	8.839716e-03	2.054
Recycling pathway of L1	R-HSA-437239	9.541725e-03	2.020
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	8.839716e-03	2.054
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	8.861438e-03	2.052
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	9.542177e-03	2.020
Transcriptional activation of p53 responsive genes	R-HSA-69560	9.542177e-03	2.020
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	9.542177e-03	2.020
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	9.732270e-03	2.012
FOXO-mediated transcription	R-HSA-9614085	1.005331e-02	1.998
HATs acetylate histones	R-HSA-3214847	1.005331e-02	1.998
MAPK family signaling cascades	R-HSA-5683057	1.022400e-02	1.990
Cellular Senescence	R-HSA-2559583	1.053686e-02	1.977
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.078514e-02	1.967
Mitotic Prophase	R-HSA-68875	1.101721e-02	1.958
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.115393e-02	1.953
Centrosome maturation	R-HSA-380287	1.125412e-02	1.949
Signaling by FGFR4	R-HSA-5654743	1.138250e-02	1.944
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.245457e-02	1.905
Regulation of KIT signaling	R-HSA-1433559	1.245457e-02	1.905
Interleukin-12 signaling	R-HSA-9020591	1.264457e-02	1.898
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.282905e-02	1.892
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.282905e-02	1.892
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.284240e-02	1.891
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.303333e-02	1.885
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.303333e-02	1.885
TCF dependent signaling in response to WNT	R-HSA-201681	1.311616e-02	1.882
Signaling by EGFR in Cancer	R-HSA-1643713	1.342971e-02	1.872
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.377760e-02	1.861
Transcriptional regulation by RUNX3	R-HSA-8878159	1.461523e-02	1.835
Ub-specific processing proteases	R-HSA-5689880	1.538531e-02	1.813
Signaling by FGFR3	R-HSA-5654741	1.533030e-02	1.814
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.512383e-02	1.820
RAF/MAP kinase cascade	R-HSA-5673001	1.395063e-02	1.855
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.454412e-02	1.837
Selective autophagy	R-HSA-9663891	1.530045e-02	1.815
Autophagy	R-HSA-9612973	1.569140e-02	1.804
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.771644e-02	1.752
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.771644e-02	1.752
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.771644e-02	1.752
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.771644e-02	1.752
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.771644e-02	1.752
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.771644e-02	1.752
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.771644e-02	1.752
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.771644e-02	1.752
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.771644e-02	1.752
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.771644e-02	1.752
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.771644e-02	1.752
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.771644e-02	1.752
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	1.592034e-02	1.798
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	1.623783e-02	1.789
Regulation of TNFR1 signaling	R-HSA-5357905	1.766101e-02	1.753
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.640906e-02	1.785
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.714080e-02	1.766
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.624777e-02	1.789
Calmodulin induced events	R-HSA-111933	1.622347e-02	1.790
CaM pathway	R-HSA-111997	1.622347e-02	1.790
Spry regulation of FGF signaling	R-HSA-1295596	1.623783e-02	1.789
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.714080e-02	1.766
Generic Transcription Pathway	R-HSA-212436	1.788045e-02	1.748
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	1.803086e-02	1.744
Downregulation of ERBB4 signaling	R-HSA-1253288	1.803086e-02	1.744
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.810696e-02	1.742
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.815174e-02	1.741
Regulation of NF-kappa B signaling	R-HSA-9758274	2.076985e-02	1.683
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.938214e-02	1.713
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.938214e-02	1.713
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.065992e-02	1.685
G1/S DNA Damage Checkpoints	R-HSA-69615	1.931847e-02	1.714
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	2.076985e-02	1.683
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.948166e-02	1.710
MAPK1/MAPK3 signaling	R-HSA-5684996	2.048227e-02	1.689
Negative regulation of FLT3	R-HSA-9706369	2.076985e-02	1.683
Formation of a pool of free 40S subunits	R-HSA-72689	2.103325e-02	1.677
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.230302e-02	1.652
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.244198e-02	1.649
Cyclin E associated events during G1/S transition	R-HSA-69202	2.265082e-02	1.645
Striated Muscle Contraction	R-HSA-390522	2.276223e-02	1.643
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.276223e-02	1.643
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	2.447277e-02	1.611
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	2.500970e-02	1.602
AKT phosphorylates targets in the nucleus	R-HSA-198693	2.500970e-02	1.602
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.326505e-02	1.633
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	2.326505e-02	1.633
IRAK1 recruits IKK complex	R-HSA-937039	2.326505e-02	1.633
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.611385e-02	1.583
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.559638e-02	1.592
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.559638e-02	1.592
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.318418e-02	1.635
Co-stimulation by CD28	R-HSA-389356	2.311879e-02	1.636
NGF-stimulated transcription	R-HSA-9031628	2.311879e-02	1.636
Hedgehog 'on' state	R-HSA-5632684	2.522533e-02	1.598
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.655401e-02	1.576
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.627837e-02	1.580
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.359087e-02	1.627
Signaling by Hedgehog	R-HSA-5358351	2.336631e-02	1.631
EPH-Ephrin signaling	R-HSA-2682334	2.497313e-02	1.603
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.316311e-02	1.635
Metabolism of RNA	R-HSA-8953854	2.676502e-02	1.572
Oxidative Stress Induced Senescence	R-HSA-2559580	2.332518e-02	1.632
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.349890e-02	1.629
Signaling by ALK in cancer	R-HSA-9700206	2.349890e-02	1.629
Cytokine Signaling in Immune system	R-HSA-1280215	2.583872e-02	1.588
Maturation of protein E	R-HSA-9694493	2.447277e-02	1.611
Maturation of protein E	R-HSA-9683683	2.447277e-02	1.611
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.691488e-02	1.570
AURKA Activation by TPX2	R-HSA-8854518	2.713309e-02	1.567
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.732245e-02	1.563
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.732245e-02	1.563
Interleukin-37 signaling	R-HSA-9008059	2.732245e-02	1.563
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.740091e-02	1.562
Muscle contraction	R-HSA-397014	2.742968e-02	1.562
Sema4D in semaphorin signaling	R-HSA-400685	2.768328e-02	1.558
Long-term potentiation	R-HSA-9620244	2.768328e-02	1.558
HDMs demethylate histones	R-HSA-3214842	2.768328e-02	1.558
Netrin-1 signaling	R-HSA-373752	2.784323e-02	1.555
RMTs methylate histone arginines	R-HSA-3214858	2.784323e-02	1.555
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.801497e-02	1.553
Macroautophagy	R-HSA-1632852	2.911257e-02	1.536
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.925687e-02	1.534
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	3.065487e-02	1.514
Diseases of Telomere Maintenance	R-HSA-9673013	3.065487e-02	1.514
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	3.065487e-02	1.514
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	3.065487e-02	1.514
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	3.065487e-02	1.514
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	3.065487e-02	1.514
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.136680e-02	1.504
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.997616e-02	1.523
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.232599e-02	1.490
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	3.232599e-02	1.490
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.307138e-02	1.481
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	3.307138e-02	1.481
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	3.198827e-02	1.495
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	3.198827e-02	1.495
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.248014e-02	1.488
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.253980e-02	1.488
Regulated Necrosis	R-HSA-5218859	3.352186e-02	1.475
Estrogen-dependent gene expression	R-HSA-9018519	3.160279e-02	1.500
G2/M Checkpoints	R-HSA-69481	3.467163e-02	1.460
Clathrin-mediated endocytosis	R-HSA-8856828	3.589087e-02	1.445
Listeria monocytogenes entry into host cells	R-HSA-8876384	3.307138e-02	1.481
Late Phase of HIV Life Cycle	R-HSA-162599	3.351047e-02	1.475
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	3.136680e-02	1.504
Membrane binding and targetting of GAG proteins	R-HSA-174490	2.997616e-02	1.523
Protein-protein interactions at synapses	R-HSA-6794362	3.214474e-02	1.493
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.997616e-02	1.523
Eukaryotic Translation Termination	R-HSA-72764	3.562829e-02	1.448
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	3.307138e-02	1.481
Heme signaling	R-HSA-9707616	3.253980e-02	1.488
Selenocysteine synthesis	R-HSA-2408557	3.565611e-02	1.448
Specification of primordial germ cells	R-HSA-9827857	3.232599e-02	1.490
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	3.543268e-02	1.451
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.620102e-02	1.441
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.620102e-02	1.441
Diseases of mitotic cell cycle	R-HSA-9675126	3.718697e-02	1.430
Neurexins and neuroligins	R-HSA-6794361	3.766574e-02	1.424
ISG15 antiviral mechanism	R-HSA-1169408	3.777172e-02	1.423
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	3.784313e-02	1.422
Glucose metabolism	R-HSA-70326	3.802005e-02	1.420
Degradation of GLI1 by the proteasome	R-HSA-5610780	3.824770e-02	1.417
Degradation of GLI2 by the proteasome	R-HSA-5610783	3.824770e-02	1.417
Negative regulation of MAPK pathway	R-HSA-5675221	3.824770e-02	1.417
Signaling by NTRK2 (TRKB)	R-HSA-9006115	3.860662e-02	1.413
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.907428e-02	1.408
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.945418e-02	1.404
Synaptic adhesion-like molecules	R-HSA-8849932	3.945418e-02	1.404
Transport of connexons to the plasma membrane	R-HSA-190872	3.945418e-02	1.404
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.945418e-02	1.404
Notch-HLH transcription pathway	R-HSA-350054	3.949115e-02	1.404
mTORC1-mediated signalling	R-HSA-166208	3.949115e-02	1.404
HIV Life Cycle	R-HSA-162587	3.967039e-02	1.402
UCH proteinases	R-HSA-5689603	4.151742e-02	1.382
Signaling by NOTCH1	R-HSA-1980143	4.151742e-02	1.382
Regulation of gap junction activity	R-HSA-191650	4.917078e-02	1.308
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.917078e-02	1.308
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	4.917078e-02	1.308
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	4.859668e-02	1.313
RUNX3 regulates WNT signaling	R-HSA-8951430	4.859668e-02	1.313
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	4.859668e-02	1.313
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	4.859668e-02	1.313
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	4.691567e-02	1.329
IKK complex recruitment mediated by RIP1	R-HSA-937041	4.753709e-02	1.323
Activation of AMPK downstream of NMDARs	R-HSA-9619483	4.503578e-02	1.346
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.214228e-02	1.283
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	4.294244e-02	1.367
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	4.294244e-02	1.367
IPs transport between nucleus and cytosol	R-HSA-1855170	4.294244e-02	1.367
Metabolism of non-coding RNA	R-HSA-194441	4.344420e-02	1.362
snRNP Assembly	R-HSA-191859	4.344420e-02	1.362
HDACs deacetylate histones	R-HSA-3214815	5.220822e-02	1.282
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	4.440451e-02	1.353
Transcriptional regulation by small RNAs	R-HSA-5578749	4.950123e-02	1.305
Cellular response to starvation	R-HSA-9711097	4.226568e-02	1.374
Regulation of MECP2 expression and activity	R-HSA-9022692	4.294244e-02	1.367
Regulation of necroptotic cell death	R-HSA-5675482	4.294244e-02	1.367
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.950123e-02	1.305
Mitotic G1 phase and G1/S transition	R-HSA-453279	4.380165e-02	1.359
Activation of PUMA and translocation to mitochondria	R-HSA-139915	4.859668e-02	1.313
DNA Damage Recognition in GG-NER	R-HSA-5696394	4.927568e-02	1.307
MTOR signalling	R-HSA-165159	4.333205e-02	1.363
p53-Dependent G1 DNA Damage Response	R-HSA-69563	5.079604e-02	1.294
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	5.079604e-02	1.294
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.917078e-02	1.308
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.814947e-02	1.317
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.814947e-02	1.317
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.814947e-02	1.317
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.814947e-02	1.317
Meiotic synapsis	R-HSA-1221632	4.214558e-02	1.375
Negative regulation of FGFR1 signaling	R-HSA-5654726	4.294244e-02	1.367
Regulation of PTEN gene transcription	R-HSA-8943724	4.814947e-02	1.317
Ca-dependent events	R-HSA-111996	4.333205e-02	1.363
MECP2 regulates transcription factors	R-HSA-9022707	4.859668e-02	1.313
Regulation of PTEN localization	R-HSA-8948747	4.859668e-02	1.313
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	4.629995e-02	1.334
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.814947e-02	1.317
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	4.927568e-02	1.307
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	4.879389e-02	1.312
Influenza Infection	R-HSA-168255	5.048241e-02	1.297
Interleukin-12 family signaling	R-HSA-447115	4.208356e-02	1.376
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	5.248101e-02	1.280
NS1 Mediated Effects on Host Pathways	R-HSA-168276	5.248101e-02	1.280
PLC beta mediated events	R-HSA-112043	5.320021e-02	1.274
Cell-Cell communication	R-HSA-1500931	5.327235e-02	1.273
DNA Double Strand Break Response	R-HSA-5693606	5.384910e-02	1.269
Oncogenic MAPK signaling	R-HSA-6802957	5.429871e-02	1.265
EPHB-mediated forward signaling	R-HSA-3928662	5.486677e-02	1.261
Eukaryotic Translation Initiation	R-HSA-72613	5.522008e-02	1.258
Cap-dependent Translation Initiation	R-HSA-72737	5.522008e-02	1.258
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.537797e-02	1.257
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	5.537797e-02	1.257
Signaling by GSK3beta mutants	R-HSA-5339716	5.537797e-02	1.257
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	5.537797e-02	1.257
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	5.620457e-02	1.250
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	5.620457e-02	1.250
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.620457e-02	1.250
Nuclear import of Rev protein	R-HSA-180746	5.620457e-02	1.250
Co-inhibition by CTLA4	R-HSA-389513	5.660353e-02	1.247
Negative regulation of MET activity	R-HSA-6807004	5.660353e-02	1.247
Post-chaperonin tubulin folding pathway	R-HSA-389977	5.660353e-02	1.247
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.722675e-02	1.242
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	5.722675e-02	1.242
Signaling by EGFR	R-HSA-177929	5.781292e-02	1.238
Signaling by FGFR1	R-HSA-5654736	5.781292e-02	1.238
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	5.781292e-02	1.238
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	6.318959e-02	1.199
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	6.318959e-02	1.199
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	7.088862e-02	1.149
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	7.088862e-02	1.149
Type I hemidesmosome assembly	R-HSA-446107	6.422564e-02	1.192
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	6.878046e-02	1.163
RUNX3 regulates p14-ARF	R-HSA-8951936	6.878046e-02	1.163
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	6.878046e-02	1.163
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	6.878046e-02	1.163
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	6.878046e-02	1.163
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	6.878046e-02	1.163
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	6.878046e-02	1.163
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.775039e-02	1.109
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.994480e-02	1.222
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	6.374361e-02	1.196
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.919226e-02	1.228
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.424977e-02	1.129
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	6.830625e-02	1.166
Signaling downstream of RAS mutants	R-HSA-9649948	6.830625e-02	1.166
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	6.830625e-02	1.166
HSF1-dependent transactivation	R-HSA-3371571	6.283744e-02	1.202
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	7.664089e-02	1.116
Viral mRNA Translation	R-HSA-192823	6.649276e-02	1.177
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.879229e-02	1.162
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.576382e-02	1.121
IGF1R signaling cascade	R-HSA-2428924	7.051174e-02	1.152
Signaling by FGFR2	R-HSA-5654738	5.918927e-02	1.228
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.320722e-02	1.135
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	6.879229e-02	1.162
PKA-mediated phosphorylation of CREB	R-HSA-111931	6.667197e-02	1.176
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	7.702523e-02	1.113
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	6.381241e-02	1.195
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	7.088862e-02	1.149
Signaling by RAS mutants	R-HSA-6802949	6.830625e-02	1.166
VLDLR internalisation and degradation	R-HSA-8866427	6.878046e-02	1.163
Budding and maturation of HIV virion	R-HSA-162588	6.845727e-02	1.165
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	5.918927e-02	1.228
Signaling by LTK	R-HSA-9842663	6.878046e-02	1.163
Signaling by WNT	R-HSA-195721	7.626964e-02	1.118
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.320722e-02	1.135
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	6.422564e-02	1.192
Developmental Biology	R-HSA-1266738	7.563742e-02	1.121
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	7.768861e-02	1.110
Response of endothelial cells to shear stress	R-HSA-9860931	7.135359e-02	1.147
NrCAM interactions	R-HSA-447038	7.088862e-02	1.149
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.422564e-02	1.192
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	7.768861e-02	1.110
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.973626e-02	1.157
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	7.775039e-02	1.109
Regulation of CDH1 Gene Transcription	R-HSA-9764560	7.049028e-02	1.152
FLT3 signaling in disease	R-HSA-9682385	7.190372e-02	1.143
Interactions of Rev with host cellular proteins	R-HSA-177243	5.919226e-02	1.228
SARS-CoV-2-host interactions	R-HSA-9705683	6.445937e-02	1.191
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	6.422564e-02	1.192
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.667197e-02	1.176
p75NTR recruits signalling complexes	R-HSA-209543	6.878046e-02	1.163
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.775039e-02	1.109
Modulation by Mtb of host immune system	R-HSA-9637628	6.422564e-02	1.192
Circadian clock	R-HSA-9909396	7.817543e-02	1.107
Golgi-to-ER retrograde transport	R-HSA-8856688	7.817543e-02	1.107
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	8.069209e-02	1.093
Ovarian tumor domain proteases	R-HSA-5689896	8.069209e-02	1.093
Vpr-mediated nuclear import of PICs	R-HSA-180910	8.069209e-02	1.093
Signaling by EGFRvIII in Cancer	R-HSA-5637812	8.161137e-02	1.088
Constitutive Signaling by EGFRvIII	R-HSA-5637810	8.161137e-02	1.088
Neuronal System	R-HSA-112316	8.179553e-02	1.087
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	8.216006e-02	1.085
Inactivation of CDC42 and RAC1	R-HSA-428543	8.216006e-02	1.085
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	8.216006e-02	1.085
Interaction between L1 and Ankyrins	R-HSA-445095	8.372300e-02	1.077
Packaging Of Telomere Ends	R-HSA-171306	8.372300e-02	1.077
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.381351e-02	1.077
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.381351e-02	1.077
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	8.381351e-02	1.077
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	8.381351e-02	1.077
Platelet activation, signaling and aggregation	R-HSA-76002	8.522519e-02	1.069
Meiosis	R-HSA-1500620	8.781514e-02	1.056
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	8.983632e-02	1.047
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.983632e-02	1.047
Cilium Assembly	R-HSA-5617833	8.989573e-02	1.046
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.011213e-02	1.045
G-protein mediated events	R-HSA-112040	9.119573e-02	1.040
Signaling by SCF-KIT	R-HSA-1433557	9.153320e-02	1.038
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.225435e-02	1.035
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.319675e-02	1.031
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	9.528090e-02	1.021
PKA activation in glucagon signalling	R-HSA-164378	9.566691e-02	1.019
Ephrin signaling	R-HSA-3928664	9.566691e-02	1.019
PKA activation	R-HSA-163615	9.566691e-02	1.019
TRAIL signaling	R-HSA-75158	9.614442e-02	1.017
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	9.614442e-02	1.017
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	9.614442e-02	1.017
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	9.614442e-02	1.017
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	9.614442e-02	1.017
Regulation of CDH19 Expression and Function	R-HSA-9764302	9.614442e-02	1.017
ESR-mediated signaling	R-HSA-8939211	9.678776e-02	1.014
Cellular responses to mechanical stimuli	R-HSA-9855142	9.693527e-02	1.014
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	9.735479e-02	1.012
Effects of PIP2 hydrolysis	R-HSA-114508	9.831823e-02	1.007
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.266184e-01	0.898
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.266184e-01	0.898
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.266184e-01	0.898
Regulation of TP53 Expression	R-HSA-6804754	1.030265e-01	0.987
Regulation of cortical dendrite branching	R-HSA-8985801	1.030265e-01	0.987
Potassium transport channels	R-HSA-1296067	1.030265e-01	0.987
CREB phosphorylation	R-HSA-199920	1.244808e-01	0.905
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.244132e-01	0.905
Signaling by APC mutants	R-HSA-4839744	1.244132e-01	0.905
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.244132e-01	0.905
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.244132e-01	0.905
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.244132e-01	0.905
Reduction of cytosolic Ca++ levels	R-HSA-418359	1.483715e-01	0.829
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.483715e-01	0.829
Translesion synthesis by REV1	R-HSA-110312	1.185559e-01	0.926
Beta-catenin phosphorylation cascade	R-HSA-196299	1.185559e-01	0.926
Translesion synthesis by POLI	R-HSA-5656121	1.381007e-01	0.860
Phosphorylation of the APC/C	R-HSA-176412	1.381007e-01	0.860
Phase 4 - resting membrane potential	R-HSA-5576886	1.381007e-01	0.860
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.169703e-01	0.932
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.448604e-01	0.839
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	1.072690e-01	0.970
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.202744e-01	0.920
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.478594e-01	0.830
EGFR downregulation	R-HSA-182971	1.340737e-01	0.873
Regulation of RUNX3 expression and activity	R-HSA-8941858	1.108415e-01	0.955
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.108415e-01	0.955
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.110564e-01	0.954
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.110564e-01	0.954
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.327853e-01	0.877
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	1.369991e-01	0.863
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.217310e-01	0.915
Transcriptional regulation by RUNX2	R-HSA-8878166	1.004359e-01	0.998
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.448604e-01	0.839
Activation of SMO	R-HSA-5635838	1.381007e-01	0.860
Ion homeostasis	R-HSA-5578775	1.007466e-01	0.997
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.009489e-01	0.996
DNA Double-Strand Break Repair	R-HSA-5693532	1.330695e-01	0.876
G1/S Transition	R-HSA-69206	1.473904e-01	0.832
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	1.004293e-01	0.998
Signaling by RAF1 mutants	R-HSA-9656223	1.340424e-01	0.873
Homology Directed Repair	R-HSA-5693538	1.368134e-01	0.864
MAP2K and MAPK activation	R-HSA-5674135	1.340424e-01	0.873
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.153386e-01	0.938
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.241542e-01	0.906
PTEN Regulation	R-HSA-6807070	1.217551e-01	0.915
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.453861e-01	0.837
Platelet calcium homeostasis	R-HSA-418360	1.072690e-01	0.970
Integration of energy metabolism	R-HSA-163685	1.457179e-01	0.836
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.442801e-01	0.841
Cardiac conduction	R-HSA-5576891	1.067932e-01	0.971
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.022774e-01	0.990
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.442801e-01	0.841
S Phase	R-HSA-69242	1.037744e-01	0.984
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.039134e-01	0.983
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.202744e-01	0.920
Assembly of the pre-replicative complex	R-HSA-68867	1.135663e-01	0.945
Cyclin D associated events in G1	R-HSA-69231	1.010158e-01	0.996
G1 Phase	R-HSA-69236	1.010158e-01	0.996
Interleukin-2 signaling	R-HSA-9020558	1.244132e-01	0.905
Activation of BH3-only proteins	R-HSA-114452	1.202744e-01	0.920
Host Interactions of HIV factors	R-HSA-162909	1.328571e-01	0.877
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.185559e-01	0.926
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.363484e-01	0.865
Interleukin-2 family signaling	R-HSA-451927	1.108415e-01	0.955
HIV Infection	R-HSA-162906	1.458190e-01	0.836
FasL/ CD95L signaling	R-HSA-75157	1.477964e-01	0.830
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.478594e-01	0.830
VEGFR2 mediated cell proliferation	R-HSA-5218921	1.319644e-01	0.880
NRIF signals cell death from the nucleus	R-HSA-205043	1.004293e-01	0.998
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.483715e-01	0.829
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.025840e-01	0.989
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.025840e-01	0.989
Cleavage of the damaged purine	R-HSA-110331	1.480346e-01	0.830
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.004293e-01	0.998
Signaling by AMER1 mutants	R-HSA-4839748	1.483715e-01	0.829
Signaling by AXIN mutants	R-HSA-4839735	1.483715e-01	0.829
Cell-extracellular matrix interactions	R-HSA-446353	1.185559e-01	0.926
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.082232e-01	0.966
PKMTs methylate histone lysines	R-HSA-3214841	1.221385e-01	0.913
Reproduction	R-HSA-1474165	1.429743e-01	0.845
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.022774e-01	0.990
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.995042e-02	1.000
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.153386e-01	0.938
Evasion by RSV of host interferon responses	R-HSA-9833109	1.340737e-01	0.873
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.482633e-01	0.829
Glycogen metabolism	R-HSA-8982491	1.108415e-01	0.955
CASP5-mediated substrate cleavage	R-HSA-9960525	1.477964e-01	0.830
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.480346e-01	0.830
PI Metabolism	R-HSA-1483255	1.412517e-01	0.850
SARS-CoV-1-host interactions	R-HSA-9692914	1.295967e-01	0.887
Stimuli-sensing channels	R-HSA-2672351	9.926938e-02	1.003
Unfolded Protein Response (UPR)	R-HSA-381119	1.217551e-01	0.915
CASP4-mediated substrate cleavage	R-HSA-9960519	1.477964e-01	0.830
NF-kB is activated and signals survival	R-HSA-209560	1.483715e-01	0.829
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.108415e-01	0.955
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.221385e-01	0.913
p75NTR signals via NF-kB	R-HSA-193639	1.185559e-01	0.926
XBP1(S) activates chaperone genes	R-HSA-381038	1.014109e-01	0.994
Pexophagy	R-HSA-9664873	1.022774e-01	0.990
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.097089e-01	0.960
Signaling by MET	R-HSA-6806834	1.487776e-01	0.827
IRE1alpha activates chaperones	R-HSA-381070	1.496446e-01	0.825
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.499762e-01	0.824
MAP kinase activation	R-HSA-450294	1.499762e-01	0.824
G2/M DNA damage checkpoint	R-HSA-69473	1.528539e-01	0.816
Signaling by ERBB4	R-HSA-1236394	1.528539e-01	0.816
DNA Replication Pre-Initiation	R-HSA-69002	1.532944e-01	0.814
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.540556e-01	0.812
Nef Mediated CD4 Down-regulation	R-HSA-167590	1.554001e-01	0.809
Activated NTRK3 signals through PI3K	R-HSA-9603381	1.554001e-01	0.809
TRIF-mediated programmed cell death	R-HSA-2562578	1.554001e-01	0.809
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.569802e-01	0.804
Processing of DNA double-strand break ends	R-HSA-5693607	1.585305e-01	0.800
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.589538e-01	0.799
Translesion synthesis by POLK	R-HSA-5655862	1.589538e-01	0.799
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.589538e-01	0.799
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	1.589538e-01	0.799
Ribosome-associated quality control	R-HSA-9948299	1.603164e-01	0.795
Depurination	R-HSA-73927	1.621256e-01	0.790
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.630030e-01	0.788
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.630030e-01	0.788
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.630030e-01	0.788
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.634061e-01	0.787
Assembly Of The HIV Virion	R-HSA-175474	1.634061e-01	0.787
Cell junction organization	R-HSA-446728	1.634329e-01	0.787
Cardiogenesis	R-HSA-9733709	1.639352e-01	0.785
Nuclear RNA decay	R-HSA-9930044	1.639352e-01	0.785
Activation of ATR in response to replication stress	R-HSA-176187	1.639352e-01	0.785
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.639352e-01	0.785
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.652644e-01	0.782
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.652644e-01	0.782
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.680487e-01	0.775
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.680487e-01	0.775
PI3K Cascade	R-HSA-109704	1.693253e-01	0.771
Interleukin-1 family signaling	R-HSA-446652	1.722524e-01	0.764
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	1.726958e-01	0.763
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.726958e-01	0.763
Signaling by PTK6	R-HSA-8848021	1.726958e-01	0.763
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.739342e-01	0.760
Role of second messengers in netrin-1 signaling	R-HSA-418890	1.739342e-01	0.760
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	1.739342e-01	0.760
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	1.739342e-01	0.760
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.372110e-01	0.625
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.372110e-01	0.625
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.372110e-01	0.625
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	2.372110e-01	0.625
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.372110e-01	0.625
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	2.372110e-01	0.625
Defective Mismatch Repair Associated With MSH3	R-HSA-5632927	2.372110e-01	0.625
TICAM1 deficiency - HSE	R-HSA-5602566	2.372110e-01	0.625
TNFR1-mediated ceramide production	R-HSA-5626978	1.956128e-01	0.709
HCN channels	R-HSA-1296061	1.956128e-01	0.709
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.956128e-01	0.709
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.956128e-01	0.709
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.956128e-01	0.709
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.956128e-01	0.709
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.956128e-01	0.709
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.338053e-01	0.477
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	R-HSA-73930	3.338053e-01	0.477
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	3.338053e-01	0.477
Interactions of Tat with host cellular proteins	R-HSA-176034	3.338053e-01	0.477
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.338053e-01	0.477
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	3.338053e-01	0.477
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.338053e-01	0.477
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	3.338053e-01	0.477
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	3.338053e-01	0.477
Signaling by TCF7L2 mutants	R-HSA-5339700	3.338053e-01	0.477
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.338053e-01	0.477
IKBKB deficiency causes SCID	R-HSA-5602636	3.338053e-01	0.477
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.338053e-01	0.477
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.338053e-01	0.477
XAV939 stabilizes AXIN	R-HSA-5545619	3.338053e-01	0.477
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.338053e-01	0.477
TRAF3 deficiency - HSE	R-HSA-5602571	3.338053e-01	0.477
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	3.338053e-01	0.477
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.338053e-01	0.477
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.338053e-01	0.477
Intestinal infectious diseases	R-HSA-8942233	3.338053e-01	0.477
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	3.338053e-01	0.477
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.449873e-01	0.611
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	2.449873e-01	0.611
IRS activation	R-HSA-74713	2.449873e-01	0.611
G2 Phase	R-HSA-68911	2.449873e-01	0.611
NOSIP mediated eNOS trafficking	R-HSA-203754	2.449873e-01	0.611
Regulation by c-FLIP	R-HSA-3371378	1.883943e-01	0.725
Dimerization of procaspase-8	R-HSA-69416	1.883943e-01	0.725
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.229664e-01	0.652
ARMS-mediated activation	R-HSA-170984	2.229664e-01	0.652
Lipophagy	R-HSA-9613354	2.229664e-01	0.652
WNT mediated activation of DVL	R-HSA-201688	2.229664e-01	0.652
CASP8 activity is inhibited	R-HSA-5218900	2.229664e-01	0.652
ALK mutants bind TKIs	R-HSA-9700645	2.229664e-01	0.652
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.947593e-01	0.531
Noncanonical activation of NOTCH3	R-HSA-9017802	2.947593e-01	0.531
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.008696e-01	0.697
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.008696e-01	0.697
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.008696e-01	0.697
MET activates RAP1 and RAC1	R-HSA-8875555	2.586461e-01	0.587
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.289397e-01	0.640
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	3.440370e-01	0.463
Signaling by LTK in cancer	R-HSA-9842640	3.440370e-01	0.463
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.040808e-01	0.690
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	2.949984e-01	0.530
RHOBTB3 ATPase cycle	R-HSA-9706019	2.949984e-01	0.530
DCC mediated attractive signaling	R-HSA-418885	2.579065e-01	0.589
PI-3K cascade:FGFR3	R-HSA-5654710	2.280805e-01	0.642
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.280805e-01	0.642
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.799243e-01	0.745
Downstream signaling of activated FGFR3	R-HSA-5654708	2.004412e-01	0.698
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.004412e-01	0.698
Termination of translesion DNA synthesis	R-HSA-5656169	2.004412e-01	0.698
DNA methylation	R-HSA-5334118	2.004412e-01	0.698
PI-3K cascade:FGFR4	R-HSA-5654720	2.528464e-01	0.597
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.528464e-01	0.597
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.528464e-01	0.597
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.528464e-01	0.597
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.528464e-01	0.597
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	2.875373e-01	0.541
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.875373e-01	0.541
Condensation of Prometaphase Chromosomes	R-HSA-2514853	3.316303e-01	0.479
RAF activation	R-HSA-5673000	1.965624e-01	0.706
Downstream signaling of activated FGFR4	R-HSA-5654716	2.194016e-01	0.659
Attenuation phase	R-HSA-3371568	1.921141e-01	0.716
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	3.176086e-01	0.498
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.389673e-01	0.622
Vif-mediated degradation of APOBEC3G	R-HSA-180585	2.315920e-01	0.635
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	2.020134e-01	0.695
Degradation of AXIN	R-HSA-4641257	2.498791e-01	0.602
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	2.914333e-01	0.535
EPHA-mediated growth cone collapse	R-HSA-3928663	2.914333e-01	0.535
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.914333e-01	0.535
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.914333e-01	0.535
PI3K events in ERBB2 signaling	R-HSA-1963642	3.479092e-01	0.459
PI-3K cascade:FGFR1	R-HSA-5654689	3.302940e-01	0.481
Translation initiation complex formation	R-HSA-72649	2.246551e-01	0.648
HIV elongation arrest and recovery	R-HSA-167287	3.146630e-01	0.502
Pausing and recovery of HIV elongation	R-HSA-167290	3.146630e-01	0.502
Vpu mediated degradation of CD4	R-HSA-180534	3.005721e-01	0.522
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	2.395100e-01	0.621
Nuclear Receptor transcription pathway	R-HSA-383280	1.961044e-01	0.708
Regulation of RAS by GAPs	R-HSA-5658442	2.649326e-01	0.577
Ribosomal scanning and start codon recognition	R-HSA-72702	2.547182e-01	0.594
Dual Incision in GG-NER	R-HSA-5696400	3.218284e-01	0.492
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.985068e-01	0.525
Formation of RNA Pol II elongation complex	R-HSA-112382	2.985068e-01	0.525
Condensation of Prophase Chromosomes	R-HSA-2299718	3.120299e-01	0.506
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	3.120299e-01	0.506
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	3.268646e-01	0.486
Downstream signaling of activated FGFR1	R-HSA-5654687	3.433212e-01	0.464
Downstream signaling of activated FGFR2	R-HSA-5654696	3.433212e-01	0.464
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.156905e-01	0.501
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	3.156905e-01	0.501
HCMV Early Events	R-HSA-9609690	2.573657e-01	0.589
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.910401e-01	0.536
RUNX2 regulates bone development	R-HSA-8941326	2.315920e-01	0.635
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	3.268646e-01	0.486
Signaling by NOTCH2	R-HSA-1980145	1.965624e-01	0.706
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	2.242773e-01	0.649
Specification of the neural plate border	R-HSA-9834899	2.280805e-01	0.642
IRS-related events triggered by IGF1R	R-HSA-2428928	2.309127e-01	0.637
Signaling by FGFR	R-HSA-190236	2.302100e-01	0.638
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.479092e-01	0.459
Prolonged ERK activation events	R-HSA-169893	2.875373e-01	0.541
Epigenetic regulation of gene expression	R-HSA-212165	3.179705e-01	0.498
IRS-mediated signalling	R-HSA-112399	2.702494e-01	0.568
Insulin receptor signalling cascade	R-HSA-74751	2.745602e-01	0.561
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.925682e-01	0.534
Downstream TCR signaling	R-HSA-202424	2.725783e-01	0.565
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.188869e-01	0.660
Signal attenuation	R-HSA-74749	2.586461e-01	0.587
Degradation of DVL	R-HSA-4641258	2.498791e-01	0.602
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	3.136128e-01	0.504
Regulation of PTEN stability and activity	R-HSA-8948751	2.101826e-01	0.677
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.326711e-01	0.633
Resolution of D-Loop Structures	R-HSA-5693537	3.005721e-01	0.522
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.229664e-01	0.652
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.579065e-01	0.589
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.032614e-01	0.692
Pyroptosis	R-HSA-5620971	1.821550e-01	0.740
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.243921e-01	0.649
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.796266e-01	0.553
HDR through Homologous Recombination (HRR)	R-HSA-5685942	2.227788e-01	0.652
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	2.860723e-01	0.544
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	3.268646e-01	0.486
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.977209e-01	0.704
Signalling to ERKs	R-HSA-187687	2.138019e-01	0.670
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.624249e-01	0.581
MHC class II antigen presentation	R-HSA-2132295	1.764170e-01	0.753
Activation of NOXA and translocation to mitochondria	R-HSA-111448	1.956128e-01	0.709
Aryl hydrocarbon receptor signalling	R-HSA-8937144	2.947593e-01	0.531
Regulation of CDH11 function	R-HSA-9762292	2.586461e-01	0.587
PI3K/AKT activation	R-HSA-198203	2.586461e-01	0.587
Lysosphingolipid and LPA receptors	R-HSA-419408	2.579065e-01	0.589
Meiotic recombination	R-HSA-912446	1.824929e-01	0.739
Activation of NF-kappaB in B cells	R-HSA-1169091	2.815745e-01	0.550
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.638423e-01	0.579
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.874972e-01	0.727
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.780856e-01	0.556
Regulation of mitotic cell cycle	R-HSA-453276	2.780856e-01	0.556
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.276915e-01	0.643
Opioid Signalling	R-HSA-111885	3.005212e-01	0.522
Dopamine receptors	R-HSA-390651	1.956128e-01	0.709
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	2.449873e-01	0.611
Adrenoceptors	R-HSA-390696	1.883943e-01	0.725
DARPP-32 events	R-HSA-180024	2.004412e-01	0.698
Glycogen breakdown (glycogenolysis)	R-HSA-70221	2.461974e-01	0.609
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.921141e-01	0.716
Trafficking of AMPA receptors	R-HSA-399719	2.389673e-01	0.622
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.079429e-01	0.682
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.315920e-01	0.635
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	3.302940e-01	0.481
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	3.479092e-01	0.459
TCR signaling	R-HSA-202403	3.012747e-01	0.521
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.937421e-01	0.713
MyD88-independent TLR4 cascade	R-HSA-166166	2.247885e-01	0.648
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	2.914333e-01	0.535
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.247885e-01	0.648
DNA Repair	R-HSA-73894	2.784799e-01	0.555
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.759068e-01	0.755
GPER1 signaling	R-HSA-9634597	2.326711e-01	0.633
Potassium Channels	R-HSA-1296071	2.084891e-01	0.681
Switching of origins to a post-replicative state	R-HSA-69052	3.072662e-01	0.512
Organelle biogenesis and maintenance	R-HSA-1852241	2.051389e-01	0.688
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.389673e-01	0.622
Signaling by WNT in cancer	R-HSA-4791275	2.590668e-01	0.587
Signaling by FGFR1 in disease	R-HSA-5655302	3.467798e-01	0.460
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.853591e-01	0.545
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.449873e-01	0.611
Stabilization of p53	R-HSA-69541	1.768297e-01	0.752
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.479092e-01	0.459
Intraflagellar transport	R-HSA-5620924	3.491110e-01	0.457
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.948002e-01	0.710
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	3.005721e-01	0.522
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	2.045403e-01	0.689
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.120818e-01	0.673
The NLRP3 inflammasome	R-HSA-844456	2.280805e-01	0.642
Signaling by Nuclear Receptors	R-HSA-9006931	2.110921e-01	0.676
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.391341e-01	0.621
Signaling by NOTCH	R-HSA-157118	1.822636e-01	0.739
Formation of intermediate mesoderm	R-HSA-9761174	2.586461e-01	0.587
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.579065e-01	0.589
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	3.316303e-01	0.479
Elevation of cytosolic Ca2+ levels	R-HSA-139853	3.479092e-01	0.459
Degradation of CDH1	R-HSA-9766229	2.486191e-01	0.604
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.218284e-01	0.492
Interleukin-1 signaling	R-HSA-9020702	3.512673e-01	0.454
Amyloid fiber formation	R-HSA-977225	2.319048e-01	0.635
Receptor Mediated Mitophagy	R-HSA-8934903	2.586461e-01	0.587
Neurofascin interactions	R-HSA-447043	3.440370e-01	0.463
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.381681e-01	0.471
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.920150e-01	0.535
Gap junction assembly	R-HSA-190861	3.218284e-01	0.492
Protein methylation	R-HSA-8876725	2.579065e-01	0.589
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	3.040959e-01	0.517
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.031700e-01	0.692
Vesicle-mediated transport	R-HSA-5653656	2.098487e-01	0.678
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	3.233344e-01	0.490
Adherens junctions interactions	R-HSA-418990	3.341225e-01	0.476
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.004412e-01	0.698
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.145537e-01	0.668
FLT3 signaling through SRC family kinases	R-HSA-9706374	1.956128e-01	0.709
Manipulation of host energy metabolism	R-HSA-9636667	3.338053e-01	0.477
Mitochondrial transcription initiation	R-HSA-163282	3.338053e-01	0.477
Transport of connexins along the secretory pathway	R-HSA-190827	3.338053e-01	0.477
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.449873e-01	0.611
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.229664e-01	0.652
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.947593e-01	0.531
Formation of the Editosome	R-HSA-75094	2.947593e-01	0.531
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.008696e-01	0.697
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	2.586461e-01	0.587
Regulation of FZD by ubiquitination	R-HSA-4641263	1.809917e-01	0.742
Bicarbonate transporters	R-HSA-425381	2.949984e-01	0.530
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.875373e-01	0.541
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.176086e-01	0.498
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.873703e-01	0.727
RNA Polymerase I Promoter Opening	R-HSA-73728	2.914333e-01	0.535
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	1.847865e-01	0.733
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	3.330864e-01	0.477
Viral Messenger RNA Synthesis	R-HSA-168325	3.349667e-01	0.475
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.516295e-01	0.454
Signaling by TGFB family members	R-HSA-9006936	2.374738e-01	0.624
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.170967e-01	0.663
Formation of the nephric duct	R-HSA-9830364	2.461974e-01	0.609
Signaling by NTRK3 (TRKC)	R-HSA-9034015	3.040959e-01	0.517
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.567326e-01	0.591
Assembly of the ORC complex at the origin of replication	R-HSA-68616	2.796266e-01	0.553
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	2.170112e-01	0.664
GP1b-IX-V activation signalling	R-HSA-430116	2.229664e-01	0.652
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.335117e-01	0.632
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.579065e-01	0.589
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.362988e-01	0.473
Gene Silencing by RNA	R-HSA-211000	2.662558e-01	0.575
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	2.410763e-01	0.618
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.780856e-01	0.556
MAPK6/MAPK4 signaling	R-HSA-5687128	2.007662e-01	0.697
Transcriptional Regulation by VENTX	R-HSA-8853884	3.268646e-01	0.486
Signaling by ALK	R-HSA-201556	1.768297e-01	0.752
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.547182e-01	0.594
Interleukin-17 signaling	R-HSA-448424	2.638423e-01	0.579
Oncogene Induced Senescence	R-HSA-2559585	2.138019e-01	0.670
Oligomerization of connexins into connexons	R-HSA-190704	3.338053e-01	0.477
Tandem pore domain potassium channels	R-HSA-1296346	2.586461e-01	0.587
Formation of the anterior neural plate	R-HSA-9823739	2.579065e-01	0.589
Regulation of gene expression in beta cells	R-HSA-210745	2.004412e-01	0.698
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.176086e-01	0.498
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.796266e-01	0.553
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.120299e-01	0.506
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.330864e-01	0.477
Signaling by NOTCH3	R-HSA-9012852	2.395100e-01	0.621
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.782330e-01	0.556
Sodium/Proton exchangers	R-HSA-425986	1.883943e-01	0.725
Sodium-coupled phosphate cotransporters	R-HSA-427652	2.947593e-01	0.531
Base-Excision Repair, AP Site Formation	R-HSA-73929	3.330864e-01	0.477
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	2.289397e-01	0.640
Mitophagy	R-HSA-5205647	3.218284e-01	0.492
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	3.176086e-01	0.498
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.020134e-01	0.695
SARS-CoV-2 Infection	R-HSA-9694516	3.504954e-01	0.455
Cleavage of the damaged pyrimidine	R-HSA-110329	2.410763e-01	0.618
Depyrimidination	R-HSA-73928	2.410763e-01	0.618
PECAM1 interactions	R-HSA-210990	2.949984e-01	0.530
SARS-CoV-1 Infection	R-HSA-9678108	3.210581e-01	0.493
Glycogen synthesis	R-HSA-3322077	2.528464e-01	0.597
Regulation of BACH1 activity	R-HSA-9708530	2.875373e-01	0.541
Glycogen storage diseases	R-HSA-3229121	3.479092e-01	0.459
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	3.302940e-01	0.481
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	3.521792e-01	0.453
Interleukin receptor SHC signaling	R-HSA-912526	3.566916e-01	0.448
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	3.566916e-01	0.448
Syndecan interactions	R-HSA-3000170	3.566916e-01	0.448
DAP12 signaling	R-HSA-2424491	3.618519e-01	0.441
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.618519e-01	0.441
HSF1 activation	R-HSA-3371511	3.649774e-01	0.438
PRC2 methylates histones and DNA	R-HSA-212300	3.649774e-01	0.438
Triglyceride catabolism	R-HSA-163560	3.649774e-01	0.438
DNA Damage Bypass	R-HSA-73893	3.678876e-01	0.434
Gap junction trafficking and regulation	R-HSA-157858	3.678876e-01	0.434
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	3.681932e-01	0.434
RUNX3 regulates NOTCH signaling	R-HSA-8941856	3.681932e-01	0.434
SHC-related events triggered by IGF1R	R-HSA-2428933	3.681932e-01	0.434
Repression of WNT target genes	R-HSA-4641265	3.681932e-01	0.434
Interleukin-15 signaling	R-HSA-8983432	3.681932e-01	0.434
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	3.683575e-01	0.434
Platelet degranulation	R-HSA-114608	3.719983e-01	0.429
GAB1 signalosome	R-HSA-180292	3.782431e-01	0.422
Mismatch Repair	R-HSA-5358508	3.782431e-01	0.422
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.782431e-01	0.422
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	3.782431e-01	0.422
PCP/CE pathway	R-HSA-4086400	3.831183e-01	0.417
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.831591e-01	0.417
TRAF6 mediated NF-kB activation	R-HSA-933542	3.831591e-01	0.417
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	3.831591e-01	0.417
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.831591e-01	0.417
NoRC negatively regulates rRNA expression	R-HSA-427413	3.842737e-01	0.415
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	3.856211e-01	0.414
Downstream signal transduction	R-HSA-186763	3.856211e-01	0.414
Regulation of CDH1 Function	R-HSA-9764561	3.861546e-01	0.413
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	3.867256e-01	0.413
SIRT1 negatively regulates rRNA expression	R-HSA-427359	3.867256e-01	0.413
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.870075e-01	0.412
Ion channel transport	R-HSA-983712	3.885393e-01	0.411
Activated NTRK2 signals through CDK5	R-HSA-9032845	3.921478e-01	0.407
MET activates PI3K/AKT signaling	R-HSA-8851907	3.921478e-01	0.407
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.921478e-01	0.407
Netrin mediated repulsion signals	R-HSA-418886	3.921478e-01	0.407
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	3.921478e-01	0.407
Cohesin Loading onto Chromatin	R-HSA-2470946	3.921478e-01	0.407
Disinhibition of SNARE formation	R-HSA-114516	3.921478e-01	0.407
SOS-mediated signalling	R-HSA-112412	3.921478e-01	0.407
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	3.921478e-01	0.407
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.921478e-01	0.407
mRNA Editing: C to U Conversion	R-HSA-72200	3.921478e-01	0.407
Ca2+ activated K+ channels	R-HSA-1296052	3.921478e-01	0.407
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	3.921478e-01	0.407
CHL1 interactions	R-HSA-447041	3.921478e-01	0.407
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.921478e-01	0.407
Uptake and function of diphtheria toxin	R-HSA-5336415	3.921478e-01	0.407
Interferon Signaling	R-HSA-913531	3.944397e-01	0.404
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	3.985855e-01	0.399
Sensory processing of sound	R-HSA-9659379	3.985855e-01	0.399
Cellular response to hypoxia	R-HSA-1234174	4.022460e-01	0.396
Formation of axial mesoderm	R-HSA-9796292	4.043837e-01	0.393
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.043837e-01	0.393
Frs2-mediated activation	R-HSA-170968	4.043837e-01	0.393
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	4.043837e-01	0.393
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	4.072081e-01	0.390
Amine ligand-binding receptors	R-HSA-375280	4.072081e-01	0.390
Translesion Synthesis by POLH	R-HSA-110320	4.084303e-01	0.389
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.084303e-01	0.389
STING mediated induction of host immune responses	R-HSA-1834941	4.084303e-01	0.389
Other interleukin signaling	R-HSA-449836	4.084303e-01	0.389
Toll-like Receptor Cascades	R-HSA-168898	4.084881e-01	0.389
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	4.093863e-01	0.388
SWI/SNF chromatin remodelers	R-HSA-9932451	4.095747e-01	0.388
ATP-dependent chromatin remodelers	R-HSA-9932444	4.095747e-01	0.388
PI-3K cascade:FGFR2	R-HSA-5654695	4.095747e-01	0.388
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.095747e-01	0.388
Interleukin-7 signaling	R-HSA-1266695	4.095747e-01	0.388
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.140935e-01	0.383
Regulation of T cell activation by CD28 family	R-HSA-388841	4.156775e-01	0.381
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	4.181725e-01	0.379
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	4.181725e-01	0.379
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.181725e-01	0.379
TWIK related potassium channel (TREK)	R-HSA-1299503	4.181725e-01	0.379
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.181725e-01	0.379
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.181725e-01	0.379
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	4.181725e-01	0.379
Transcription from mitochondrial promoters	R-HSA-75944	4.181725e-01	0.379
DSCAM interactions	R-HSA-376172	4.181725e-01	0.379
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	4.181725e-01	0.379
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.181725e-01	0.379
MITF-M-regulated melanocyte development	R-HSA-9730414	4.208389e-01	0.376
MITF-M-dependent gene expression	R-HSA-9856651	4.234954e-01	0.373
Orc1 removal from chromatin	R-HSA-68949	4.246078e-01	0.372
RNA Polymerase I Promoter Escape	R-HSA-73772	4.246078e-01	0.372
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.273947e-01	0.369
Nucleosome assembly	R-HSA-774815	4.273947e-01	0.369
Asymmetric localization of PCP proteins	R-HSA-4608870	4.273947e-01	0.369
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.273947e-01	0.369
Transmission across Chemical Synapses	R-HSA-112315	4.281616e-01	0.368
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.302252e-01	0.366
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	4.330631e-01	0.363
FGFR1 mutant receptor activation	R-HSA-1839124	4.330631e-01	0.363
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.330631e-01	0.363
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	4.350897e-01	0.361
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	4.350897e-01	0.361
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	4.350897e-01	0.361
Cell-cell junction organization	R-HSA-421270	4.358157e-01	0.361
Myogenesis	R-HSA-525793	4.358251e-01	0.361
Signaling by FLT3 fusion proteins	R-HSA-9703465	4.358251e-01	0.361
Suppression of phagosomal maturation	R-HSA-9637687	4.358251e-01	0.361
VxPx cargo-targeting to cilium	R-HSA-5620916	4.383085e-01	0.358
Formation of definitive endoderm	R-HSA-9823730	4.383085e-01	0.358
RSK activation	R-HSA-444257	4.385973e-01	0.358
Signaling by MRAS-complex mutants	R-HSA-9660537	4.385973e-01	0.358
MET receptor recycling	R-HSA-8875656	4.385973e-01	0.358
FGFR1b ligand binding and activation	R-HSA-190370	4.385973e-01	0.358
Activation of RAS in B cells	R-HSA-1169092	4.385973e-01	0.358
Activated NTRK2 signals through PI3K	R-HSA-9028335	4.385973e-01	0.358
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.385973e-01	0.358
TGFBR3 PTM regulation	R-HSA-9839383	4.385973e-01	0.358
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.385973e-01	0.358
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	4.385973e-01	0.358
Co-stimulation by ICOS	R-HSA-9927354	4.385973e-01	0.358
Activated NTRK2 signals through FYN	R-HSA-9032500	4.385973e-01	0.358
Alpha-defensins	R-HSA-1462054	4.385973e-01	0.358
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.397350e-01	0.357
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	4.399425e-01	0.357
CRMPs in Sema3A signaling	R-HSA-399956	4.399425e-01	0.357
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	4.399425e-01	0.357
Signaling by FGFR4 in disease	R-HSA-5655291	4.399425e-01	0.357
Non-canonical inflammasome activation	R-HSA-9686114	4.399425e-01	0.357
HDL assembly	R-HSA-8963896	4.399425e-01	0.357
mRNA Splicing - Minor Pathway	R-HSA-72165	4.475159e-01	0.349
Signaling by TGFBR3	R-HSA-9839373	4.475159e-01	0.349
Diseases of DNA repair	R-HSA-9675135	4.475159e-01	0.349
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	4.490050e-01	0.348
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.513296e-01	0.346
HIV Transcription Elongation	R-HSA-167169	4.518477e-01	0.345
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.518477e-01	0.345
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.518477e-01	0.345
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.518477e-01	0.345
Negative regulation of NOTCH4 signaling	R-HSA-9604323	4.518477e-01	0.345
Transcription of the HIV genome	R-HSA-167172	4.531233e-01	0.344
Glucagon signaling in metabolic regulation	R-HSA-163359	4.565720e-01	0.340
DNA Replication	R-HSA-69306	4.573234e-01	0.340
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	4.618063e-01	0.336
Signaling by FGFR3 in disease	R-HSA-5655332	4.618063e-01	0.336
Regulation of endogenous retroelements	R-HSA-9842860	4.624899e-01	0.335
SHC-mediated cascade:FGFR3	R-HSA-5654704	4.677330e-01	0.330
MyD88 deficiency (TLR2/4)	R-HSA-5602498	4.677330e-01	0.330
Signalling to RAS	R-HSA-167044	4.677330e-01	0.330
Zygotic genome activation (ZGA)	R-HSA-9819196	4.677330e-01	0.330
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	4.677330e-01	0.330
Base Excision Repair	R-HSA-73884	4.712482e-01	0.327
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.733049e-01	0.325
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	4.733049e-01	0.325
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	4.746524e-01	0.324
Activation of BAD and translocation to mitochondria	R-HSA-111447	4.746524e-01	0.324
IRF3-mediated induction of type I IFN	R-HSA-3270619	4.746524e-01	0.324
tRNA processing in the nucleus	R-HSA-6784531	4.752515e-01	0.323
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	4.760532e-01	0.322
NPAS4 regulates expression of target genes	R-HSA-9768919	4.798395e-01	0.319
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	4.798395e-01	0.319
COPI-mediated anterograde transport	R-HSA-6807878	4.810494e-01	0.318
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.830348e-01	0.316
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	4.830348e-01	0.316
Unwinding of DNA	R-HSA-176974	4.830348e-01	0.316
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	4.830348e-01	0.316
Regulation of CDH11 gene transcription	R-HSA-9762293	4.830348e-01	0.316
mRNA Editing	R-HSA-75072	4.830348e-01	0.316
Respiratory syncytial virus genome replication	R-HSA-9834752	4.830348e-01	0.316
Butyrophilin (BTN) family interactions	R-HSA-8851680	4.830348e-01	0.316
Phase 0 - rapid depolarisation	R-HSA-5576892	4.874233e-01	0.312
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.874233e-01	0.312
Telomere Extension By Telomerase	R-HSA-171319	4.874233e-01	0.312
Inflammasomes	R-HSA-622312	4.874233e-01	0.312
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.918597e-01	0.308
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	4.918597e-01	0.308
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.918597e-01	0.308
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.918597e-01	0.308
Defective GSS causes GSS deficiency	R-HSA-5579006	4.918597e-01	0.308
Invadopodia formation	R-HSA-8941237	4.918597e-01	0.308
Defective CYP1B1 causes Glaucoma	R-HSA-5579000	4.918597e-01	0.308
Classical Kir channels	R-HSA-1296053	4.918597e-01	0.308
MET activates PTPN11	R-HSA-8865999	4.918597e-01	0.308
Defective GCLC causes HAGGSD	R-HSA-5578999	4.918597e-01	0.308
MET interacts with TNS proteins	R-HSA-8875513	4.918597e-01	0.308
Activation of BIM and translocation to mitochondria	R-HSA-111446	4.918597e-01	0.308
Histamine receptors	R-HSA-390650	4.918597e-01	0.308
HCMV Infection	R-HSA-9609646	4.927177e-01	0.307
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.928467e-01	0.307
Degradation of CRY and PER proteins	R-HSA-9932298	4.945416e-01	0.306
Translation of Structural Proteins	R-HSA-9683701	4.945416e-01	0.306
Telomere Maintenance	R-HSA-157579	4.952938e-01	0.305
SHC-mediated cascade:FGFR4	R-HSA-5654719	4.965769e-01	0.304
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	4.965769e-01	0.304
Signaling by PDGFR in disease	R-HSA-9671555	4.965769e-01	0.304
PERK regulates gene expression	R-HSA-381042	5.027976e-01	0.299
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.027976e-01	0.299
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	5.027976e-01	0.299
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	5.027976e-01	0.299
Regulation of Apoptosis	R-HSA-169911	5.027976e-01	0.299
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	5.034366e-01	0.298
Beta-catenin independent WNT signaling	R-HSA-3858494	5.042751e-01	0.297
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	5.083356e-01	0.294
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.083356e-01	0.294
Differentiation of T cells	R-HSA-9945266	5.083356e-01	0.294
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	5.083356e-01	0.294
Signaling by Erythropoietin	R-HSA-9006335	5.125914e-01	0.290
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.125914e-01	0.290
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	5.125914e-01	0.290
Signaling by Insulin receptor	R-HSA-74752	5.154117e-01	0.288
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	5.154117e-01	0.288
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	5.161812e-01	0.287
Nucleotide Excision Repair	R-HSA-5696398	5.175396e-01	0.286
FGFR2 alternative splicing	R-HSA-6803529	5.247308e-01	0.280
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	5.247308e-01	0.280
Signaling by KIT in disease	R-HSA-9669938	5.247308e-01	0.280
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.251126e-01	0.280
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.252250e-01	0.280
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	5.252250e-01	0.280
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	5.252250e-01	0.280
EGFR Transactivation by Gastrin	R-HSA-2179392	5.252250e-01	0.280
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.252250e-01	0.280
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	5.252250e-01	0.280
Signaling by Leptin	R-HSA-2586552	5.252250e-01	0.280
G1/S-Specific Transcription	R-HSA-69205	5.253846e-01	0.280
GPVI-mediated activation cascade	R-HSA-114604	5.253846e-01	0.280
PKR-mediated signaling	R-HSA-9833482	5.287412e-01	0.277
Dual incision in TC-NER	R-HSA-6782135	5.360052e-01	0.271
Defective pyroptosis	R-HSA-9710421	5.361513e-01	0.271
Response of Mtb to phagocytosis	R-HSA-9637690	5.361513e-01	0.271
Activation of the pre-replicative complex	R-HSA-68962	5.372351e-01	0.270
Transcriptional regulation of testis differentiation	R-HSA-9690406	5.408503e-01	0.267
Acetylcholine regulates insulin secretion	R-HSA-399997	5.408503e-01	0.267
TRAF3-dependent IRF activation pathway	R-HSA-918233	5.408503e-01	0.267
Disorders of Developmental Biology	R-HSA-9675151	5.408503e-01	0.267
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	5.408503e-01	0.267
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	5.443084e-01	0.264
Voltage gated Potassium channels	R-HSA-1296072	5.475448e-01	0.262
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.521021e-01	0.258
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.521021e-01	0.258
Signaling by NOTCH4	R-HSA-9013694	5.524484e-01	0.258
Regulation of beta-cell development	R-HSA-186712	5.538725e-01	0.257
ATP sensitive Potassium channels	R-HSA-1296025	5.562182e-01	0.255
Defective LFNG causes SCDO3	R-HSA-5083630	5.562182e-01	0.255
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.562182e-01	0.255
MDK and PTN in ALK signaling	R-HSA-9851151	5.562182e-01	0.255
NADE modulates death signalling	R-HSA-205025	5.562182e-01	0.255
Sensory perception of sour taste	R-HSA-9729555	5.562182e-01	0.255
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.562182e-01	0.255
Gap junction trafficking	R-HSA-190828	5.564339e-01	0.255
Class I MHC mediated antigen processing & presentation	R-HSA-983169	5.565143e-01	0.255
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	5.612886e-01	0.251
Kidney development	R-HSA-9830369	5.614390e-01	0.251
TP53 Regulates Metabolic Genes	R-HSA-5628897	5.640515e-01	0.249
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	5.643204e-01	0.248
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.643204e-01	0.248
Activated NTRK3 signals through RAS	R-HSA-9034864	5.650245e-01	0.248
FGFR2b ligand binding and activation	R-HSA-190377	5.650245e-01	0.248
Presynaptic depolarization and calcium channel opening	R-HSA-112308	5.650245e-01	0.248
Formation of the posterior neural plate	R-HSA-9832991	5.650245e-01	0.248
Ionotropic activity of kainate receptors	R-HSA-451306	5.650245e-01	0.248
Synthesis of PI	R-HSA-1483226	5.650245e-01	0.248
ER-Phagosome pathway	R-HSA-1236974	5.663514e-01	0.247
MET promotes cell motility	R-HSA-8875878	5.692289e-01	0.245
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	5.692289e-01	0.245
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.720877e-01	0.243
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	5.720877e-01	0.243
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	5.720877e-01	0.243
Defective CFTR causes cystic fibrosis	R-HSA-5678895	5.763152e-01	0.239
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	5.763152e-01	0.239
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	5.763152e-01	0.239
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	5.763152e-01	0.239
SHC-mediated cascade:FGFR1	R-HSA-5654688	5.786141e-01	0.238
Deadenylation of mRNA	R-HSA-429947	5.786141e-01	0.238
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	5.786141e-01	0.238
Plasma lipoprotein assembly	R-HSA-8963898	5.786141e-01	0.238
Selenoamino acid metabolism	R-HSA-2408522	5.789082e-01	0.237
Gastrulation	R-HSA-9758941	5.797412e-01	0.237
Amino acids regulate mTORC1	R-HSA-9639288	5.827696e-01	0.235
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	5.827696e-01	0.235
RNA Polymerase I Promoter Clearance	R-HSA-73854	5.840847e-01	0.234
Inwardly rectifying K+ channels	R-HSA-1296065	5.846955e-01	0.233
HCMV Late Events	R-HSA-9610379	5.847296e-01	0.233
Cellular response to chemical stress	R-HSA-9711123	5.854777e-01	0.232
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	5.865034e-01	0.232
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	5.903932e-01	0.229
Plasma lipoprotein clearance	R-HSA-8964043	5.903932e-01	0.229
RAS processing	R-HSA-9648002	5.903932e-01	0.229
Regulation of pyruvate metabolism	R-HSA-9861718	5.957606e-01	0.225
rRNA processing	R-HSA-72312	5.997768e-01	0.222
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.019678e-01	0.220
Apoptotic factor-mediated response	R-HSA-111471	6.019678e-01	0.220
Tie2 Signaling	R-HSA-210993	6.019678e-01	0.220
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	6.023620e-01	0.220
Activated NTRK2 signals through RAS	R-HSA-9026519	6.023620e-01	0.220
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	6.023620e-01	0.220
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	6.023620e-01	0.220
Cytochrome c-mediated apoptotic response	R-HSA-111461	6.023620e-01	0.220
Sodium/Calcium exchangers	R-HSA-425561	6.023620e-01	0.220
Signaling by activated point mutants of FGFR1	R-HSA-1839122	6.023620e-01	0.220
TGFBR3 expression	R-HSA-9839394	6.042052e-01	0.219
G-protein beta:gamma signalling	R-HSA-397795	6.074082e-01	0.217
Inositol phosphate metabolism	R-HSA-1483249	6.096434e-01	0.215
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.110003e-01	0.214
Diseases of Immune System	R-HSA-5260271	6.110003e-01	0.214
Diseases associated with the TLR signaling cascade	R-HSA-5602358	6.110003e-01	0.214
Nuclear signaling by ERBB4	R-HSA-1251985	6.110003e-01	0.214
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	6.124287e-01	0.213
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	6.124287e-01	0.213
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	6.124287e-01	0.213
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	6.124287e-01	0.213
Post-transcriptional silencing by small RNAs	R-HSA-426496	6.124287e-01	0.213
Activation of AKT2	R-HSA-165158	6.124287e-01	0.213
PTK6 Down-Regulation	R-HSA-8849472	6.124287e-01	0.213
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	6.124287e-01	0.213
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	6.124287e-01	0.213
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	6.124287e-01	0.213
Muscarinic acetylcholine receptors	R-HSA-390648	6.124287e-01	0.213
Nectin/Necl trans heterodimerization	R-HSA-420597	6.124287e-01	0.213
Regulation of insulin secretion	R-HSA-422356	6.136980e-01	0.212
RNA Polymerase I Transcription	R-HSA-73864	6.147040e-01	0.211
Protein folding	R-HSA-391251	6.230333e-01	0.205
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	6.288276e-01	0.201
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	6.288276e-01	0.201
Miscellaneous transport and binding events	R-HSA-5223345	6.293877e-01	0.201
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.304366e-01	0.200
Maturation of nucleoprotein	R-HSA-9694631	6.304366e-01	0.200
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.310182e-01	0.200
Hh mutants are degraded by ERAD	R-HSA-5362768	6.310182e-01	0.200
Metal ion SLC transporters	R-HSA-425410	6.332258e-01	0.198
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.372226e-01	0.196
Scavenging by Class F Receptors	R-HSA-3000484	6.372226e-01	0.196
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	6.372226e-01	0.196
MET activates RAS signaling	R-HSA-8851805	6.372226e-01	0.196
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	6.372226e-01	0.196
Regulation of IFNG signaling	R-HSA-877312	6.372226e-01	0.196
Pervasive developmental disorders	R-HSA-9005895	6.372226e-01	0.196
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.372226e-01	0.196
Disorders of Nervous System Development	R-HSA-9697154	6.372226e-01	0.196
OAS antiviral response	R-HSA-8983711	6.372226e-01	0.196
Ion transport by P-type ATPases	R-HSA-936837	6.384777e-01	0.195
Chaperonin-mediated protein folding	R-HSA-390466	6.470695e-01	0.189
Chromosome Maintenance	R-HSA-73886	6.497911e-01	0.187
SARS-CoV Infections	R-HSA-9679506	6.502544e-01	0.187
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	6.504207e-01	0.187
HIV Transcription Initiation	R-HSA-167161	6.504207e-01	0.187
RNA Polymerase II Transcription Initiation	R-HSA-75953	6.504207e-01	0.187
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	6.506030e-01	0.187
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.506030e-01	0.187
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.506030e-01	0.187
Calnexin/calreticulin cycle	R-HSA-901042	6.506030e-01	0.187
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.524462e-01	0.185
SHC-mediated cascade:FGFR2	R-HSA-5654699	6.524462e-01	0.185
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	6.524462e-01	0.185
ER Quality Control Compartment (ERQC)	R-HSA-901032	6.524462e-01	0.185
Extra-nuclear estrogen signaling	R-HSA-9009391	6.528432e-01	0.185
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.556988e-01	0.183
Antigen processing-Cross presentation	R-HSA-1236975	6.556988e-01	0.183
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	6.574622e-01	0.182
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	6.574622e-01	0.182
Protein hydroxylation	R-HSA-9629569	6.574622e-01	0.182
C-type lectin receptors (CLRs)	R-HSA-5621481	6.606645e-01	0.180
Adaptive Immune System	R-HSA-1280218	6.612487e-01	0.180
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.615223e-01	0.179
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.615223e-01	0.179
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	6.615223e-01	0.179
PDE3B signalling	R-HSA-165160	6.615223e-01	0.179
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.615223e-01	0.179
PKB-mediated events	R-HSA-109703	6.615223e-01	0.179
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.615223e-01	0.179
Signaling by MAPK mutants	R-HSA-9652817	6.615223e-01	0.179
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.615223e-01	0.179
Defective CSF2RA causes SMDP4	R-HSA-5688890	6.615223e-01	0.179
Defective CSF2RB causes SMDP5	R-HSA-5688849	6.615223e-01	0.179
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	6.615223e-01	0.179
CLEC7A/inflammasome pathway	R-HSA-5660668	6.615223e-01	0.179
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.615223e-01	0.179
Pentose phosphate pathway disease	R-HSA-6791465	6.615223e-01	0.179
Phosphorylation of Emi1	R-HSA-176417	6.615223e-01	0.179
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.615223e-01	0.179
IkBA variant leads to EDA-ID	R-HSA-5603029	6.615223e-01	0.179
CDC6 association with the ORC:origin complex	R-HSA-68689	6.615223e-01	0.179
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.615223e-01	0.179
Negative feedback regulation of MAPK pathway	R-HSA-5674499	6.615223e-01	0.179
Signalling to p38 via RIT and RIN	R-HSA-187706	6.615223e-01	0.179
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.615223e-01	0.179
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.615223e-01	0.179
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.615223e-01	0.179
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.615223e-01	0.179
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.615223e-01	0.179
Hemostasis	R-HSA-109582	6.657823e-01	0.177
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	6.689056e-01	0.175
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.691865e-01	0.174
FGFR2c ligand binding and activation	R-HSA-190375	6.696348e-01	0.174
Chylomicron remodeling	R-HSA-8963901	6.696348e-01	0.174
FGFR1c ligand binding and activation	R-HSA-190373	6.696348e-01	0.174
FGFR4 ligand binding and activation	R-HSA-190322	6.696348e-01	0.174
Processing of SMDT1	R-HSA-8949664	6.696348e-01	0.174
Signaling by activated point mutants of FGFR3	R-HSA-1839130	6.696348e-01	0.174
PI5P Regulates TP53 Acetylation	R-HSA-6811555	6.696348e-01	0.174
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	6.696348e-01	0.174
Maturation of nucleoprotein	R-HSA-9683610	6.696348e-01	0.174
FGFR3 mutant receptor activation	R-HSA-2033514	6.696348e-01	0.174
Regulation of PD-L1(CD274) expression	R-HSA-9909648	6.703044e-01	0.174
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	6.710307e-01	0.173
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	6.747111e-01	0.171
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	6.750373e-01	0.171
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	6.750373e-01	0.171
Phospholipid metabolism	R-HSA-1483257	6.797998e-01	0.168
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	6.830322e-01	0.166
ERK/MAPK targets	R-HSA-198753	6.830322e-01	0.166
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	6.830322e-01	0.166
Triglyceride metabolism	R-HSA-8979227	6.847762e-01	0.164
Protein ubiquitination	R-HSA-8852135	6.851855e-01	0.164
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	6.851855e-01	0.164
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	6.855229e-01	0.164
Hedgehog ligand biogenesis	R-HSA-5358346	6.855229e-01	0.164
RNA Polymerase II Promoter Escape	R-HSA-73776	6.872993e-01	0.163
Hh mutants abrogate ligand secretion	R-HSA-5387390	6.872993e-01	0.163
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	6.906541e-01	0.161
RNA Polymerase III Transcription	R-HSA-74158	6.906541e-01	0.161
Mitochondrial biogenesis	R-HSA-1592230	6.929519e-01	0.159
Neutrophil degranulation	R-HSA-6798695	6.974563e-01	0.156
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.996594e-01	0.155
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	6.996594e-01	0.155
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.996594e-01	0.155
cGMP effects	R-HSA-418457	6.996594e-01	0.155
FGFR3c ligand binding and activation	R-HSA-190372	6.996594e-01	0.155
Physiological factors	R-HSA-5578768	6.996594e-01	0.155
Zinc transporters	R-HSA-435354	6.996594e-01	0.155
Signal regulatory protein family interactions	R-HSA-391160	6.996594e-01	0.155
RAB geranylgeranylation	R-HSA-8873719	7.001631e-01	0.155
Activation of HOX genes during differentiation	R-HSA-5619507	7.015669e-01	0.154
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	7.015669e-01	0.154
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	7.018514e-01	0.154
Transcriptional Regulation by NPAS4	R-HSA-9634815	7.018514e-01	0.154
PTK6 promotes HIF1A stabilization	R-HSA-8857538	7.043997e-01	0.152
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	7.043997e-01	0.152
Erythropoietin activates STAT5	R-HSA-9027283	7.043997e-01	0.152
STAT5 Activation	R-HSA-9645135	7.043997e-01	0.152
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	7.043997e-01	0.152
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	7.043997e-01	0.152
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	7.043997e-01	0.152
Hydrolysis of LPE	R-HSA-1483152	7.043997e-01	0.152
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	7.043997e-01	0.152
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	7.043997e-01	0.152
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	7.043997e-01	0.152
G2/M DNA replication checkpoint	R-HSA-69478	7.043997e-01	0.152
Abacavir transmembrane transport	R-HSA-2161517	7.043997e-01	0.152
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	7.043997e-01	0.152
NADPH regeneration	R-HSA-389542	7.043997e-01	0.152
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	7.043997e-01	0.152
Nef and signal transduction	R-HSA-164944	7.043997e-01	0.152
CREB3 factors activate genes	R-HSA-8874211	7.043997e-01	0.152
DAP12 interactions	R-HSA-2172127	7.047476e-01	0.152
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.071503e-01	0.150
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.071503e-01	0.150
Glutathione synthesis and recycling	R-HSA-174403	7.071503e-01	0.150
Translation of Structural Proteins	R-HSA-9694635	7.125600e-01	0.147
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.170937e-01	0.144
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	7.170937e-01	0.144
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	7.170937e-01	0.144
Golgi Associated Vesicle Biogenesis	R-HSA-432722	7.176112e-01	0.144
Smooth Muscle Contraction	R-HSA-445355	7.176112e-01	0.144
ER to Golgi Anterograde Transport	R-HSA-199977	7.194106e-01	0.143
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.215238e-01	0.142
Fanconi Anemia Pathway	R-HSA-6783310	7.215238e-01	0.142
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.271685e-01	0.138
Erythropoietin activates RAS	R-HSA-9027284	7.273812e-01	0.138
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	7.273812e-01	0.138
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	7.273812e-01	0.138
SHC1 events in EGFR signaling	R-HSA-180336	7.273812e-01	0.138
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	7.273812e-01	0.138
ERBB2 Regulates Cell Motility	R-HSA-6785631	7.273812e-01	0.138
Telomere C-strand synthesis initiation	R-HSA-174430	7.273812e-01	0.138
FGFR3 ligand binding and activation	R-HSA-190239	7.273812e-01	0.138
p38MAPK events	R-HSA-171007	7.273812e-01	0.138
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	7.273812e-01	0.138
Biotin transport and metabolism	R-HSA-196780	7.273812e-01	0.138
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.274532e-01	0.138
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.298341e-01	0.137
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.298341e-01	0.137
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	7.298341e-01	0.137
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.298341e-01	0.137
Synthesis of DNA	R-HSA-69239	7.352722e-01	0.134
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.376244e-01	0.132
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.376244e-01	0.132
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	7.418477e-01	0.130
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	7.418477e-01	0.130
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.418477e-01	0.130
IFNG signaling activates MAPKs	R-HSA-9732724	7.418477e-01	0.130
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	7.418477e-01	0.130
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	7.418477e-01	0.130
FGFR3b ligand binding and activation	R-HSA-190371	7.418477e-01	0.130
DAG1 core M1 glycosylations	R-HSA-8932506	7.418477e-01	0.130
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	7.418477e-01	0.130
VLDL clearance	R-HSA-8964046	7.418477e-01	0.130
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	7.418477e-01	0.130
Phase 3 - rapid repolarisation	R-HSA-5576890	7.418477e-01	0.130
Maturation of replicase proteins	R-HSA-9694301	7.418477e-01	0.130
Potential therapeutics for SARS	R-HSA-9679191	7.470788e-01	0.127
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	7.511123e-01	0.124
Carnitine shuttle	R-HSA-200425	7.511123e-01	0.124
Growth hormone receptor signaling	R-HSA-982772	7.511123e-01	0.124
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	7.529015e-01	0.123
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.529015e-01	0.123
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.529015e-01	0.123
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	7.530497e-01	0.123
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.530497e-01	0.123
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	7.575414e-01	0.121
Ca2+ pathway	R-HSA-4086398	7.656214e-01	0.116
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	7.710226e-01	0.113
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.710226e-01	0.113
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	7.724181e-01	0.112
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.745535e-01	0.111
DAG1 core M2 glycosylations	R-HSA-8932504	7.745535e-01	0.111
Formation of annular gap junctions	R-HSA-196025	7.745535e-01	0.111
Regulation of NPAS4 mRNA translation	R-HSA-9768778	7.745535e-01	0.111
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.745535e-01	0.111
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	7.745535e-01	0.111
Interleukin-9 signaling	R-HSA-8985947	7.745535e-01	0.111
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	7.745535e-01	0.111
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	7.745535e-01	0.111
Co-inhibition by PD-1	R-HSA-389948	7.748393e-01	0.111
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.763333e-01	0.110
Phase 2 - plateau phase	R-HSA-5576893	7.763333e-01	0.110
Processing of Intronless Pre-mRNAs	R-HSA-77595	7.763333e-01	0.110
Synthesis of PG	R-HSA-1483148	7.763333e-01	0.110
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	7.765404e-01	0.110
Signaling by FGFR in disease	R-HSA-1226099	7.775463e-01	0.109
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	7.851591e-01	0.105
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	7.888511e-01	0.103
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	7.888511e-01	0.103
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.896100e-01	0.103
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.896100e-01	0.103
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.896100e-01	0.103
G protein gated Potassium channels	R-HSA-1296059	7.896100e-01	0.103
Activation of G protein gated Potassium channels	R-HSA-1296041	7.896100e-01	0.103
Tight junction interactions	R-HSA-420029	7.896100e-01	0.103
Acyl chain remodelling of PS	R-HSA-1482801	7.896100e-01	0.103
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	7.896100e-01	0.103
Signaling by FGFR2 in disease	R-HSA-5655253	7.953205e-01	0.099
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	7.977960e-01	0.098
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	7.977960e-01	0.098
Sulfide oxidation to sulfate	R-HSA-1614517	7.977960e-01	0.098
Extension of Telomeres	R-HSA-180786	8.001225e-01	0.097
Peroxisomal protein import	R-HSA-9033241	8.001225e-01	0.097
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	8.031174e-01	0.095
Interleukin-21 signaling	R-HSA-9020958	8.031174e-01	0.095
Gap junction degradation	R-HSA-190873	8.031174e-01	0.095
MASTL Facilitates Mitotic Progression	R-HSA-2465910	8.031174e-01	0.095
Defects in biotin (Btn) metabolism	R-HSA-3323169	8.031174e-01	0.095
Calcineurin activates NFAT	R-HSA-2025928	8.031174e-01	0.095
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	8.031174e-01	0.095
Interleukin-1 processing	R-HSA-448706	8.031174e-01	0.095
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	8.031174e-01	0.095
Regulated proteolysis of p75NTR	R-HSA-193692	8.031174e-01	0.095
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.043201e-01	0.095
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.043201e-01	0.095
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.069249e-01	0.093
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.174124e-01	0.088
RNA Polymerase III Transcription Termination	R-HSA-73980	8.174124e-01	0.088
Activated point mutants of FGFR2	R-HSA-2033519	8.174124e-01	0.088
FGFR1 ligand binding and activation	R-HSA-190242	8.174124e-01	0.088
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	8.174124e-01	0.088
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	8.174124e-01	0.088
Nephron development	R-HSA-9831926	8.174124e-01	0.088
Platelet sensitization by LDL	R-HSA-432142	8.174124e-01	0.088
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	8.174124e-01	0.088
Viral Infection Pathways	R-HSA-9824446	8.176742e-01	0.087
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.230219e-01	0.085
Signaling by BMP	R-HSA-201451	8.230219e-01	0.085
Aquaporin-mediated transport	R-HSA-445717	8.231304e-01	0.085
Binding and entry of HIV virion	R-HSA-173107	8.280637e-01	0.082
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	8.280637e-01	0.082
Folding of actin by CCT/TriC	R-HSA-390450	8.280637e-01	0.082
Regulation of the apoptosome activity	R-HSA-9627069	8.280637e-01	0.082
Formation of apoptosome	R-HSA-111458	8.280637e-01	0.082
2-LTR circle formation	R-HSA-164843	8.280637e-01	0.082
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.280637e-01	0.082
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	8.280637e-01	0.082
CASP4 inflammasome assembly	R-HSA-9948001	8.280637e-01	0.082
Arachidonate production from DAG	R-HSA-426048	8.280637e-01	0.082
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	8.280637e-01	0.082
Maturation of spike protein	R-HSA-9683686	8.280637e-01	0.082
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.280637e-01	0.082
Serotonin receptors	R-HSA-390666	8.280637e-01	0.082
Proteasome assembly	R-HSA-9907900	8.310384e-01	0.080
Nucleotide biosynthesis	R-HSA-8956320	8.317915e-01	0.080
Lysosome Vesicle Biogenesis	R-HSA-432720	8.324884e-01	0.080
NCAM signaling for neurite out-growth	R-HSA-375165	8.338301e-01	0.079
Signaling by PDGF	R-HSA-186797	8.338301e-01	0.079
Pre-NOTCH Processing in Golgi	R-HSA-1912420	8.353056e-01	0.078
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	8.353056e-01	0.078
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	8.353056e-01	0.078
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.353056e-01	0.078
E2F mediated regulation of DNA replication	R-HSA-113510	8.353056e-01	0.078
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.379581e-01	0.077
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	8.379581e-01	0.077
Formation of the Early Elongation Complex	R-HSA-113418	8.379581e-01	0.077
Pyrimidine salvage	R-HSA-73614	8.379581e-01	0.077
Adipogenesis	R-HSA-9843745	8.394796e-01	0.076
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.461605e-01	0.073
DAG1 core M3 glycosylations	R-HSA-8932505	8.498504e-01	0.071
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	8.498504e-01	0.071
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.498504e-01	0.071
vRNA Synthesis	R-HSA-192814	8.498504e-01	0.071
vRNP Assembly	R-HSA-192905	8.498504e-01	0.071
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.498504e-01	0.071
Chylomicron assembly	R-HSA-8963888	8.498504e-01	0.071
LGI-ADAM interactions	R-HSA-5682910	8.498504e-01	0.071
Suppression of apoptosis	R-HSA-9635465	8.498504e-01	0.071
Prostanoid ligand receptors	R-HSA-391908	8.498504e-01	0.071
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	8.515973e-01	0.070
Acyl chain remodelling of PI	R-HSA-1482922	8.515973e-01	0.070
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.515973e-01	0.070
Signal transduction by L1	R-HSA-445144	8.515973e-01	0.070
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.515973e-01	0.070
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.517924e-01	0.070
G alpha (z) signalling events	R-HSA-418597	8.530738e-01	0.069
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.571900e-01	0.067
RSV-host interactions	R-HSA-9833110	8.585535e-01	0.066
Synthesis of PC	R-HSA-1483191	8.643776e-01	0.063
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.645846e-01	0.063
Cytoprotection by HMOX1	R-HSA-9707564	8.655276e-01	0.063
G-protein activation	R-HSA-202040	8.664060e-01	0.062
FGFR2 ligand binding and activation	R-HSA-190241	8.664060e-01	0.062
Early Phase of HIV Life Cycle	R-HSA-162594	8.664060e-01	0.062
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.683315e-01	0.061
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.683315e-01	0.061
PI3K events in ERBB4 signaling	R-HSA-1250342	8.688776e-01	0.061
Sensing of DNA Double Strand Breaks	R-HSA-5693548	8.688776e-01	0.061
Plasmalogen biosynthesis	R-HSA-75896	8.688776e-01	0.061
ERKs are inactivated	R-HSA-202670	8.688776e-01	0.061
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.688776e-01	0.061
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.688776e-01	0.061
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.688776e-01	0.061
Integration of provirus	R-HSA-162592	8.688776e-01	0.061
Interferon gamma signaling	R-HSA-877300	8.715162e-01	0.060
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.720770e-01	0.059
Platelet homeostasis	R-HSA-418346	8.726590e-01	0.059
Plasma lipoprotein remodeling	R-HSA-8963899	8.741849e-01	0.058
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	8.741849e-01	0.058
Generation of second messenger molecules	R-HSA-202433	8.787167e-01	0.056
Mitochondrial calcium ion transport	R-HSA-8949215	8.798459e-01	0.056
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.808082e-01	0.055
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.819979e-01	0.055
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	8.833833e-01	0.054
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.854945e-01	0.053
GRB2 events in EGFR signaling	R-HSA-179812	8.854945e-01	0.053
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.854945e-01	0.053
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.854945e-01	0.053
Diseases associated with surfactant metabolism	R-HSA-5687613	8.854945e-01	0.053
Polymerase switching	R-HSA-69091	8.854945e-01	0.053
Leading Strand Synthesis	R-HSA-69109	8.854945e-01	0.053
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.854945e-01	0.053
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.854945e-01	0.053
DNA strand elongation	R-HSA-69190	8.872800e-01	0.052
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.877156e-01	0.052
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.888265e-01	0.051
Regulation of IFNA/IFNB signaling	R-HSA-912694	8.920260e-01	0.050
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	8.920260e-01	0.050
RAF-independent MAPK1/3 activation	R-HSA-112409	8.920260e-01	0.050
LDL clearance	R-HSA-8964038	8.920260e-01	0.050
ABC transporter disorders	R-HSA-5619084	8.943043e-01	0.049
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.944040e-01	0.048
G alpha (s) signalling events	R-HSA-418555	8.952657e-01	0.048
GABA receptor activation	R-HSA-977443	8.967360e-01	0.047
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.967360e-01	0.047
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.973003e-01	0.047
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.973698e-01	0.047
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.973698e-01	0.047
Adenylate cyclase activating pathway	R-HSA-170660	9.000065e-01	0.046
CD28 dependent Vav1 pathway	R-HSA-389359	9.000065e-01	0.046
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	9.000065e-01	0.046
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	9.000065e-01	0.046
Reversible hydration of carbon dioxide	R-HSA-1475029	9.000065e-01	0.046
Interleukin-6 signaling	R-HSA-1059683	9.000065e-01	0.046
Replication of the SARS-CoV-1 genome	R-HSA-9682706	9.000065e-01	0.046
Immune System	R-HSA-168256	9.002849e-01	0.046
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.030497e-01	0.044
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.030497e-01	0.044
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.030497e-01	0.044
Formation of the ureteric bud	R-HSA-9830674	9.030497e-01	0.044
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.030497e-01	0.044
Activation of GABAB receptors	R-HSA-991365	9.057124e-01	0.043
GABA B receptor activation	R-HSA-977444	9.057124e-01	0.043
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.057124e-01	0.043
Acyl chain remodelling of PC	R-HSA-1482788	9.065112e-01	0.043
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	9.065112e-01	0.043
Removal of the Flap Intermediate	R-HSA-69166	9.126800e-01	0.040
Retrograde neurotrophin signalling	R-HSA-177504	9.126800e-01	0.040
Synthesis of IPs in the nucleus	R-HSA-1855191	9.126800e-01	0.040
Hydrolysis of LPC	R-HSA-1483115	9.126800e-01	0.040
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.126800e-01	0.040
P2Y receptors	R-HSA-417957	9.126800e-01	0.040
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	9.126800e-01	0.040
Thromboxane signalling through TP receptor	R-HSA-428930	9.130143e-01	0.040
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.130143e-01	0.040
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	9.130143e-01	0.040
TNFs bind their physiological receptors	R-HSA-5669034	9.130143e-01	0.040
Complex III assembly	R-HSA-9865881	9.130143e-01	0.040
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.149671e-01	0.039
eNOS activation	R-HSA-203615	9.149671e-01	0.039
Signal amplification	R-HSA-392518	9.149671e-01	0.039
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.149671e-01	0.039
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.220113e-01	0.035
Laminin interactions	R-HSA-3000157	9.220113e-01	0.035
Acyl chain remodelling of PE	R-HSA-1482839	9.227205e-01	0.035
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	9.237479e-01	0.034
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.237479e-01	0.034
RNA Polymerase III Chain Elongation	R-HSA-73780	9.237479e-01	0.034
G beta:gamma signalling through BTK	R-HSA-8964315	9.237479e-01	0.034
Processive synthesis on the lagging strand	R-HSA-69183	9.237479e-01	0.034
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	9.237479e-01	0.034
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	9.237479e-01	0.034
Dopamine clearance from the synaptic cleft	R-HSA-379401	9.237479e-01	0.034
Other semaphorin interactions	R-HSA-416700	9.237479e-01	0.034
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	9.237479e-01	0.034
DNA Damage Reversal	R-HSA-73942	9.237479e-01	0.034
Developmental Cell Lineages	R-HSA-9734767	9.290739e-01	0.032
FGFR2 mutant receptor activation	R-HSA-1839126	9.298213e-01	0.032
MET activates PTK2 signaling	R-HSA-8874081	9.301258e-01	0.031
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.301258e-01	0.031
Interferon alpha/beta signaling	R-HSA-909733	9.312980e-01	0.031
ABC-family proteins mediated transport	R-HSA-382556	9.316834e-01	0.031
G alpha (q) signalling events	R-HSA-416476	9.319037e-01	0.031
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.329709e-01	0.030
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	R-HSA-2142816	9.334135e-01	0.030
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	9.334135e-01	0.030
Killing mechanisms	R-HSA-9664420	9.334135e-01	0.030
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.334135e-01	0.030
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	9.334135e-01	0.030
Atorvastatin ADME	R-HSA-9754706	9.334135e-01	0.030
TRAF6 mediated IRF7 activation	R-HSA-933541	9.363173e-01	0.029
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.368122e-01	0.028
RNA Polymerase I Transcription Termination	R-HSA-73863	9.374368e-01	0.028
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.390179e-01	0.027
Mitochondrial protein degradation	R-HSA-9837999	9.408972e-01	0.026
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.418543e-01	0.026
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	9.418543e-01	0.026
Galactose catabolism	R-HSA-70370	9.418543e-01	0.026
Coenzyme A biosynthesis	R-HSA-196783	9.418543e-01	0.026
tRNA modification in the mitochondrion	R-HSA-6787450	9.418543e-01	0.026
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.440177e-01	0.025
Insulin receptor recycling	R-HSA-77387	9.440177e-01	0.025
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.476729e-01	0.023
Deadenylation-dependent mRNA decay	R-HSA-429914	9.477064e-01	0.023
Regulation of NPAS4 gene expression	R-HSA-9768759	9.492256e-01	0.023
GDP-fucose biosynthesis	R-HSA-6787639	9.492256e-01	0.023
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.492256e-01	0.023
mRNA Capping	R-HSA-72086	9.499360e-01	0.022
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.526155e-01	0.021
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.526155e-01	0.021
Neurotransmitter clearance	R-HSA-112311	9.552540e-01	0.020
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.552540e-01	0.020
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.556628e-01	0.020
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	R-HSA-2142670	9.556628e-01	0.020
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.556628e-01	0.020
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.556628e-01	0.020
Formation of paraxial mesoderm	R-HSA-9793380	9.558290e-01	0.020
Maturation of spike protein	R-HSA-9694548	9.571190e-01	0.019
GPCR downstream signalling	R-HSA-388396	9.576007e-01	0.019
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.600286e-01	0.018
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.600286e-01	0.018
Intra-Golgi traffic	R-HSA-6811438	9.612188e-01	0.017
Uptake and actions of bacterial toxins	R-HSA-5339562	9.612537e-01	0.017
Pyrimidine biosynthesis	R-HSA-500753	9.612842e-01	0.017
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.612842e-01	0.017
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.612842e-01	0.017
HDL remodeling	R-HSA-8964058	9.612842e-01	0.017
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.612842e-01	0.017
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.641151e-01	0.016
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.643122e-01	0.016
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.661932e-01	0.015
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.661932e-01	0.015
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	9.661932e-01	0.015
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.661932e-01	0.015
Pregnenolone biosynthesis	R-HSA-196108	9.661932e-01	0.015
Signaling by NODAL	R-HSA-1181150	9.661932e-01	0.015
Eicosanoid ligand-binding receptors	R-HSA-391903	9.661932e-01	0.015
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.673027e-01	0.014
Leishmania infection	R-HSA-9658195	9.673584e-01	0.014
Parasitic Infection Pathways	R-HSA-9824443	9.673584e-01	0.014
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.681524e-01	0.014
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.697654e-01	0.013
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.704800e-01	0.013
Lagging Strand Synthesis	R-HSA-69186	9.704800e-01	0.013
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.704800e-01	0.013
Phenylalanine metabolism	R-HSA-8964208	9.704800e-01	0.013
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.704800e-01	0.013
Basigin interactions	R-HSA-210991	9.704800e-01	0.013
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.713447e-01	0.013
FCERI mediated NF-kB activation	R-HSA-2871837	9.719168e-01	0.012
Somitogenesis	R-HSA-9824272	9.742072e-01	0.011
Molybdenum cofactor biosynthesis	R-HSA-947581	9.742234e-01	0.011
Serine metabolism	R-HSA-977347	9.742234e-01	0.011
Pyruvate metabolism	R-HSA-70268	9.743737e-01	0.011
PPARA activates gene expression	R-HSA-1989781	9.747954e-01	0.011
Integrin cell surface interactions	R-HSA-216083	9.748766e-01	0.011
Cholesterol biosynthesis	R-HSA-191273	9.748766e-01	0.011
Synthesis of PA	R-HSA-1483166	9.757598e-01	0.011
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.767394e-01	0.010
Neurotoxicity of clostridium toxins	R-HSA-168799	9.774923e-01	0.010
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.774923e-01	0.010
Ethanol oxidation	R-HSA-71384	9.774923e-01	0.010
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.774923e-01	0.010
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.777176e-01	0.010
Transport to the Golgi and subsequent modification	R-HSA-948021	9.780756e-01	0.010
SLC transporter disorders	R-HSA-5619102	9.787069e-01	0.009
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.787262e-01	0.009
Parasite infection	R-HSA-9664407	9.787262e-01	0.009
Leishmania phagocytosis	R-HSA-9664417	9.787262e-01	0.009
Glycerophospholipid biosynthesis	R-HSA-1483206	9.792698e-01	0.009
Post-translational protein phosphorylation	R-HSA-8957275	9.796084e-01	0.009
Glycosphingolipid transport	R-HSA-9845576	9.798939e-01	0.009
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.798939e-01	0.009
COPII-mediated vesicle transport	R-HSA-204005	9.799346e-01	0.009
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.799845e-01	0.009
Regulation of PTEN mRNA translation	R-HSA-8943723	9.803468e-01	0.009
Free fatty acids regulate insulin secretion	R-HSA-400451	9.803468e-01	0.009
Interleukin-20 family signaling	R-HSA-8854691	9.803468e-01	0.009
Gluconeogenesis	R-HSA-70263	9.811115e-01	0.008
Signaling by Retinoic Acid	R-HSA-5362517	9.818264e-01	0.008
SLC-mediated transport of organic cations	R-HSA-549127	9.820966e-01	0.008
NCAM1 interactions	R-HSA-419037	9.820966e-01	0.008
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.828395e-01	0.008
Mitochondrial RNA degradation	R-HSA-9836573	9.828395e-01	0.008
Interleukin-6 family signaling	R-HSA-6783589	9.828395e-01	0.008
tRNA processing	R-HSA-72306	9.833533e-01	0.007
Azathioprine ADME	R-HSA-9748787	9.846916e-01	0.007
Diseases of carbohydrate metabolism	R-HSA-5663084	9.847237e-01	0.007
Hyaluronan degradation	R-HSA-2160916	9.850161e-01	0.007
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.850161e-01	0.007
Pentose phosphate pathway	R-HSA-71336	9.858208e-01	0.006
The phototransduction cascade	R-HSA-2514856	9.862281e-01	0.006
Collagen formation	R-HSA-1474290	9.866629e-01	0.006
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.869167e-01	0.006
Urea cycle	R-HSA-70635	9.869167e-01	0.006
Abacavir ADME	R-HSA-2161522	9.869167e-01	0.006
Sphingolipid catabolism	R-HSA-9845614	9.869167e-01	0.006
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.869167e-01	0.006
Iron uptake and transport	R-HSA-917937	9.872940e-01	0.006
Disorders of transmembrane transporters	R-HSA-5619115	9.873176e-01	0.006
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.873883e-01	0.006
Cristae formation	R-HSA-8949613	9.885764e-01	0.005
Triglyceride biosynthesis	R-HSA-75109	9.885764e-01	0.005
Synthesis of PE	R-HSA-1483213	9.885764e-01	0.005
Insulin processing	R-HSA-264876	9.885764e-01	0.005
Maturation of hRSV A proteins	R-HSA-9828806	9.885764e-01	0.005
Prednisone ADME	R-HSA-9757110	9.900256e-01	0.004
Signaling by GPCR	R-HSA-372790	9.909784e-01	0.004
Cytosolic tRNA aminoacylation	R-HSA-379716	9.911436e-01	0.004
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.912581e-01	0.004
Thyroxine biosynthesis	R-HSA-209968	9.912911e-01	0.004
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.912911e-01	0.004
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.912911e-01	0.004
Glucagon-type ligand receptors	R-HSA-420092	9.912911e-01	0.004
Defensins	R-HSA-1461973	9.921330e-01	0.003
Surfactant metabolism	R-HSA-5683826	9.930140e-01	0.003
Cargo concentration in the ER	R-HSA-5694530	9.933608e-01	0.003
Degradation of cysteine and homocysteine	R-HSA-1614558	9.937982e-01	0.003
Metabolism of cofactors	R-HSA-8978934	9.939059e-01	0.003
Amino acid transport across the plasma membrane	R-HSA-352230	9.941794e-01	0.003
DAG1 glycosylations	R-HSA-8931838	9.942033e-01	0.003
Glutathione conjugation	R-HSA-156590	9.947825e-01	0.002
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.953022e-01	0.002
Nucleotide salvage	R-HSA-8956321	9.953247e-01	0.002
Heme degradation	R-HSA-189483	9.955812e-01	0.002
Mitochondrial protein import	R-HSA-1268020	9.958120e-01	0.002
Citric acid cycle (TCA cycle)	R-HSA-71403	9.959546e-01	0.002
Role of phospholipids in phagocytosis	R-HSA-2029485	9.960406e-01	0.002
Hyaluronan metabolism	R-HSA-2142845	9.961420e-01	0.002
RA biosynthesis pathway	R-HSA-5365859	9.961420e-01	0.002
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.961420e-01	0.002
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.966316e-01	0.001
Transferrin endocytosis and recycling	R-HSA-917977	9.966316e-01	0.001
Neurotransmitter release cycle	R-HSA-112310	9.972625e-01	0.001
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.974325e-01	0.001
Collagen chain trimerization	R-HSA-8948216	9.974325e-01	0.001
SLC-mediated transport of amino acids	R-HSA-9958863	9.975962e-01	0.001
Purine salvage	R-HSA-74217	9.977584e-01	0.001
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.978508e-01	0.001
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.980430e-01	0.001
Neddylation	R-HSA-8951664	9.980953e-01	0.001
Formation of the cornified envelope	R-HSA-6809371	9.981972e-01	0.001
Protein localization	R-HSA-9609507	9.982649e-01	0.001
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.982763e-01	0.001
Leishmania parasite growth and survival	R-HSA-9664433	9.982763e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.982834e-01	0.001
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.985400e-01	0.001
Scavenging by Class A Receptors	R-HSA-3000480	9.986977e-01	0.001
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.987729e-01	0.001
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.988548e-01	0.000
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.988631e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.989085e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.989907e-01	0.000
Metabolism of polyamines	R-HSA-351202	9.989907e-01	0.000
Collagen degradation	R-HSA-1442490	9.991072e-01	0.000
Endogenous sterols	R-HSA-211976	9.991072e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.991684e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.993838e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.995740e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.996125e-01	0.000
Innate Immune System	R-HSA-168249	9.996403e-01	0.000
Complex IV assembly	R-HSA-9864848	9.996652e-01	0.000
Branched-chain amino acid catabolism	R-HSA-70895	9.996652e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.997064e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.997407e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.997407e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.997407e-01	0.000
Purine catabolism	R-HSA-74259	9.997711e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.997834e-01	0.000
Paracetamol ADME	R-HSA-9753281	9.998056e-01	0.000
Translation	R-HSA-72766	9.998114e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.998303e-01	0.000
Digestion	R-HSA-8935690	9.998303e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.998472e-01	0.000
Dectin-2 family	R-HSA-5621480	9.998519e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.998856e-01	0.000
Sialic acid metabolism	R-HSA-4085001	9.998871e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.998918e-01	0.000
FCGR activation	R-HSA-2029481	9.999046e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999258e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.999337e-01	0.000
Digestion and absorption	R-HSA-8963743	9.999345e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999349e-01	0.000
Glycosphingolipid biosynthesis	R-HSA-9840309	9.999428e-01	0.000
Xenobiotics	R-HSA-211981	9.999428e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999465e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.999536e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.999620e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999652e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.999668e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999729e-01	0.000
Infectious disease	R-HSA-5663205	9.999751e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.999779e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999810e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999915e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999924e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999925e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999939e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999941e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999967e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999967e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999969e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999974e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999977e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999984e-01	0.000
Disease	R-HSA-1643685	9.999985e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999987e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999987e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999990e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999993e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999997e-01	0.000
Keratinization	R-HSA-6805567	9.999997e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999999e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999999e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999999e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999999e-01	0.000
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cellular responses to stress	R-HSA-2262752	3.735900e-13	12.428
Cellular responses to stimuli	R-HSA-8953897	2.243095e-12	11.649
Cellular response to heat stress	R-HSA-3371556	3.660342e-10	9.436
Axon guidance	R-HSA-422475	3.524288e-09	8.453
Nervous system development	R-HSA-9675108	7.468811e-09	8.127
Apoptotic execution phase	R-HSA-75153	7.111518e-09	8.148
Recycling pathway of L1	R-HSA-437239	1.001464e-08	7.999
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.554216e-09	8.020
Cell Cycle, Mitotic	R-HSA-69278	2.238548e-08	7.650
Cell Cycle	R-HSA-1640170	2.729743e-08	7.564
Mitotic Prometaphase	R-HSA-68877	3.440880e-08	7.463
Interleukin-12 signaling	R-HSA-9020591	4.860334e-08	7.313
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	8.731494e-08	7.059
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.334098e-07	6.875
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.420921e-07	6.847
HSF1-dependent transactivation	R-HSA-3371571	1.455207e-07	6.837
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	2.084084e-07	6.681
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.084391e-07	6.681
Post NMDA receptor activation events	R-HSA-438064	2.334163e-07	6.632
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	5.770222e-07	6.239
Separation of Sister Chromatids	R-HSA-2467813	5.508769e-07	6.259
M Phase	R-HSA-68886	6.020815e-07	6.220
Interleukin-12 family signaling	R-HSA-447115	7.176007e-07	6.144
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	7.743569e-07	6.111
L1CAM interactions	R-HSA-373760	7.515328e-07	6.124
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.235618e-07	6.035
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	8.899179e-07	6.051
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.169756e-06	5.932
HSF1 activation	R-HSA-3371511	1.189049e-06	5.925
Transport of connexons to the plasma membrane	R-HSA-190872	1.496705e-06	5.825
Kinesins	R-HSA-983189	1.582644e-06	5.801
Signaling by RAF1 mutants	R-HSA-9656223	1.836236e-06	5.736
Signaling by RAS mutants	R-HSA-6802949	1.970300e-06	5.705
Signaling downstream of RAS mutants	R-HSA-9649948	1.970300e-06	5.705
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.970300e-06	5.705
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.970300e-06	5.705
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.853198e-06	5.732
Metabolism of RNA	R-HSA-8953854	2.131113e-06	5.671
Mitotic Anaphase	R-HSA-68882	3.908128e-06	5.408
Attenuation phase	R-HSA-3371568	4.006018e-06	5.397
Mitotic Metaphase and Anaphase	R-HSA-2555396	4.372605e-06	5.359
Activation of AMPK downstream of NMDARs	R-HSA-9619483	4.844614e-06	5.315
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	4.970884e-06	5.304
mRNA Splicing - Major Pathway	R-HSA-72163	5.816966e-06	5.235
Signal Transduction	R-HSA-162582	5.830007e-06	5.234
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.843179e-06	5.233
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	6.993048e-06	5.155
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	7.355381e-06	5.133
Cell-Cell communication	R-HSA-1500931	1.089464e-05	4.963
G2/M Transition	R-HSA-69275	1.062928e-05	4.973
Mitotic G2-G2/M phases	R-HSA-453274	1.337067e-05	4.874
Gap junction trafficking and regulation	R-HSA-157858	1.499071e-05	4.824
Gap junction trafficking	R-HSA-190828	1.526150e-05	4.816
mRNA Splicing	R-HSA-72172	1.985952e-05	4.702
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.490449e-05	4.604
Apoptosis	R-HSA-109581	2.681813e-05	4.572
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.796017e-05	4.553
Chaperonin-mediated protein folding	R-HSA-390466	4.547749e-05	4.342
Aggrephagy	R-HSA-9646399	5.369873e-05	4.270
Post-chaperonin tubulin folding pathway	R-HSA-389977	8.788113e-05	4.056
MAP2K and MAPK activation	R-HSA-5674135	8.640708e-05	4.063
Regulation of MECP2 expression and activity	R-HSA-9022692	8.909017e-05	4.050
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	9.742257e-05	4.011
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	9.765226e-05	4.010
Cohesin Loading onto Chromatin	R-HSA-2470946	1.073060e-04	3.969
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.136458e-04	3.944
Protein folding	R-HSA-391251	1.154656e-04	3.938
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.253715e-04	3.902
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.484228e-04	3.828
Gap junction assembly	R-HSA-190861	1.484608e-04	3.828
Oncogenic MAPK signaling	R-HSA-6802957	1.867840e-04	3.729
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.879077e-04	3.726
Cell junction organization	R-HSA-446728	1.895445e-04	3.722
Ribosomal scanning and start codon recognition	R-HSA-72702	2.022729e-04	3.694
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.124279e-04	3.673
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	2.200611e-04	3.657
PKR-mediated signaling	R-HSA-9833482	2.200611e-04	3.657
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.233667e-04	3.651
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.973992e-04	3.527
Membrane Trafficking	R-HSA-199991	2.981193e-04	3.526
Golgi-to-ER retrograde transport	R-HSA-8856688	2.999569e-04	3.523
Programmed Cell Death	R-HSA-5357801	3.257649e-04	3.487
Translation initiation complex formation	R-HSA-72649	3.976585e-04	3.400
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	4.030970e-04	3.395
Regulation of CDH1 Expression and Function	R-HSA-9764265	4.030970e-04	3.395
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.134460e-04	3.384
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	4.744785e-04	3.324
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	5.149924e-04	3.288
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.439573e-04	3.264
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	6.691755e-04	3.174
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	6.705857e-04	3.174
Loss of Nlp from mitotic centrosomes	R-HSA-380259	6.705857e-04	3.174
Cell Cycle Checkpoints	R-HSA-69620	6.897161e-04	3.161
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	7.862035e-04	3.104
ChREBP activates metabolic gene expression	R-HSA-163765	7.914423e-04	3.102
Selective autophagy	R-HSA-9663891	7.865930e-04	3.104
Signaling by ROBO receptors	R-HSA-376176	8.589997e-04	3.066
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	8.923009e-04	3.049
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.923009e-04	3.049
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.042964e-03	2.982
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.042964e-03	2.982
AURKA Activation by TPX2	R-HSA-8854518	1.060760e-03	2.974
Cell-extracellular matrix interactions	R-HSA-446353	1.031166e-03	2.987
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.042964e-03	2.982
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.195870e-03	2.922
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.195870e-03	2.922
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.287586e-03	2.890
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.400281e-03	2.854
Cellular Senescence	R-HSA-2559583	1.412588e-03	2.850
Nephrin family interactions	R-HSA-373753	1.508509e-03	2.821
Cap-dependent Translation Initiation	R-HSA-72737	1.654361e-03	2.781
Eukaryotic Translation Initiation	R-HSA-72613	1.654361e-03	2.781
MHC class II antigen presentation	R-HSA-2132295	1.672482e-03	2.777
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.686673e-03	2.773
Adherens junctions interactions	R-HSA-418990	1.686778e-03	2.773
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.693216e-03	2.771
S Phase	R-HSA-69242	1.820330e-03	2.740
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.847491e-03	2.733
Mitotic Spindle Checkpoint	R-HSA-69618	1.922856e-03	2.716
Glycolysis	R-HSA-70171	1.922856e-03	2.716
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	2.060647e-03	2.686
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.148105e-03	2.668
Interferon Signaling	R-HSA-913531	2.204111e-03	2.657
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.434194e-03	2.614
Amplification of signal from the kinetochores	R-HSA-141424	2.728124e-03	2.564
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.728124e-03	2.564
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	2.737838e-03	2.563
Folding of actin by CCT/TriC	R-HSA-390450	2.737838e-03	2.563
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	2.771951e-03	2.557
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.790437e-03	2.554
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.803145e-03	2.552
Eukaryotic Translation Elongation	R-HSA-156842	3.161803e-03	2.500
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.195315e-03	2.495
Cell-cell junction organization	R-HSA-421270	3.438723e-03	2.464
Centrosome maturation	R-HSA-380287	3.556213e-03	2.449
ISG15 antiviral mechanism	R-HSA-1169408	3.556213e-03	2.449
Autophagy	R-HSA-9612973	3.599419e-03	2.444
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	3.794289e-03	2.421
Striated Muscle Contraction	R-HSA-390522	3.850370e-03	2.414
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	4.403491e-03	2.356
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.266785e-03	2.370
Nuclear Envelope Breakdown	R-HSA-2980766	4.267396e-03	2.370
RAF activation	R-HSA-5673000	4.608385e-03	2.336
Interactions of Rev with host cellular proteins	R-HSA-177243	4.658295e-03	2.332
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.867607e-03	2.313
Neurodegenerative Diseases	R-HSA-8863678	4.947771e-03	2.306
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	4.947771e-03	2.306
Activation of the pre-replicative complex	R-HSA-68962	5.327979e-03	2.273
Cilium Assembly	R-HSA-5617833	5.348962e-03	2.272
Activation of RAC1	R-HSA-428540	5.433304e-03	2.265
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	5.433304e-03	2.265
Developmental Lineages of the Mammary Gland	R-HSA-9924644	5.487371e-03	2.261
Formation of annular gap junctions	R-HSA-196025	6.457448e-03	2.190
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	6.438320e-03	2.191
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.813659e-03	2.236
Vpr-mediated nuclear import of PICs	R-HSA-180910	7.610778e-03	2.119
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.610778e-03	2.119
rRNA processing in the nucleus and cytosol	R-HSA-8868773	7.854937e-03	2.105
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	8.893126e-03	2.051
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	8.903435e-03	2.050
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	8.903435e-03	2.050
Gap junction degradation	R-HSA-190873	9.172787e-03	2.037
ALK mutants bind TKIs	R-HSA-9700645	9.172787e-03	2.037
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	9.682584e-03	2.014
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	9.690352e-03	2.014
Notch-HLH transcription pathway	R-HSA-350054	1.025456e-02	1.989
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.046978e-02	1.980
Chaperone Mediated Autophagy	R-HSA-9613829	1.155578e-02	1.937
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.115877e-02	1.952
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.136898e-02	1.944
COPI-mediated anterograde transport	R-HSA-6807878	1.055998e-02	1.976
Cytokine Signaling in Immune system	R-HSA-1280215	1.110221e-02	1.955
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.195283e-02	1.923
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.242383e-02	1.906
Nuclear import of Rev protein	R-HSA-180746	1.242383e-02	1.906
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.242556e-02	1.906
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.253098e-02	1.902
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.258700e-02	1.900
Signal attenuation	R-HSA-74749	1.258700e-02	1.900
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.258700e-02	1.900
Apoptosis induced DNA fragmentation	R-HSA-140342	1.258700e-02	1.900
Glucose metabolism	R-HSA-70326	1.278425e-02	1.893
EPH-Ephrin signaling	R-HSA-2682334	1.285733e-02	1.891
HCMV Early Events	R-HSA-9609690	1.313005e-02	1.882
CREB phosphorylation	R-HSA-199920	1.547040e-02	1.810
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.488689e-02	1.827
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.470833e-02	1.832
ESR-mediated signaling	R-HSA-8939211	1.527299e-02	1.816
Signaling by VEGF	R-HSA-194138	1.446046e-02	1.840
Regulation of PTEN gene transcription	R-HSA-8943724	1.407799e-02	1.851
Smooth Muscle Contraction	R-HSA-445355	1.362620e-02	1.866
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.422699e-02	1.847
MITF-M-regulated melanocyte development	R-HSA-9730414	1.507489e-02	1.822
Unfolded Protein Response (UPR)	R-HSA-381119	1.550428e-02	1.810
Negative regulation of MAPK pathway	R-HSA-5675221	1.575522e-02	1.803
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.591000e-02	1.798
Intraflagellar transport	R-HSA-5620924	1.666038e-02	1.778
Organelle biogenesis and maintenance	R-HSA-1852241	1.711334e-02	1.767
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.739826e-02	1.759
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.742088e-02	1.759
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.742088e-02	1.759
Sema4D in semaphorin signaling	R-HSA-400685	1.774983e-02	1.751
Macroautophagy	R-HSA-1632852	1.783095e-02	1.749
Ca-dependent events	R-HSA-111996	1.796591e-02	1.746
Formation of a pool of free 40S subunits	R-HSA-72689	1.831043e-02	1.737
ERK/MAPK targets	R-HSA-198753	2.098810e-02	1.678
Regulation of CDH1 Function	R-HSA-9764561	2.152995e-02	1.667
Semaphorin interactions	R-HSA-373755	1.951824e-02	1.710
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.929411e-02	1.715
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.155049e-02	1.667
Host Interactions of HIV factors	R-HSA-162909	2.174389e-02	1.663
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.175857e-02	1.662
IFNG signaling activates MAPKs	R-HSA-9732724	2.175857e-02	1.662
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.178856e-02	1.662
Muscle contraction	R-HSA-397014	2.221205e-02	1.653
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	2.227445e-02	1.652
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.306711e-02	1.637
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.320956e-02	1.634
IPs transport between nucleus and cytosol	R-HSA-1855170	2.340846e-02	1.631
Activation of ATR in response to replication stress	R-HSA-176187	2.340846e-02	1.631
Nonsense-Mediated Decay (NMD)	R-HSA-927802	2.358009e-02	1.627
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	2.358009e-02	1.627
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.372109e-02	1.625
XBP1(S) activates chaperone genes	R-HSA-381038	2.491698e-02	1.604
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.501718e-02	1.602
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.501718e-02	1.602
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.506246e-02	1.601
mRNA 3'-end processing	R-HSA-72187	2.645938e-02	1.577
Death Receptor Signaling	R-HSA-73887	2.681808e-02	1.572
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.689656e-02	1.570
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.689656e-02	1.570
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.769061e-02	1.558
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.940679e-02	1.532
RSK activation	R-HSA-444257	2.940679e-02	1.532
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.945619e-02	1.531
Peptide chain elongation	R-HSA-156902	2.946411e-02	1.531
Diseases of programmed cell death	R-HSA-9645723	2.946411e-02	1.531
FGFR2 alternative splicing	R-HSA-6803529	2.964741e-02	1.528
Signaling by Hippo	R-HSA-2028269	2.969379e-02	1.527
Influenza Infection	R-HSA-168255	3.068521e-02	1.513
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.561971e-02	1.448
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	3.494064e-02	1.457
HDACs deacetylate histones	R-HSA-3214815	3.617109e-02	1.442
Regulation of endogenous retroelements	R-HSA-9842860	3.196744e-02	1.495
Downregulation of ERBB2 signaling	R-HSA-8863795	3.783714e-02	1.422
Ephrin signaling	R-HSA-3928664	3.561971e-02	1.448
PKMTs methylate histone lysines	R-HSA-3214841	3.200181e-02	1.495
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.476611e-02	1.459
PLC beta mediated events	R-HSA-112043	3.243286e-02	1.489
Estrogen-dependent gene expression	R-HSA-9018519	3.536922e-02	1.451
Polo-like kinase mediated events	R-HSA-156711	3.561971e-02	1.448
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.191726e-02	1.496
Transcriptional Regulation by MECP2	R-HSA-8986944	3.740229e-02	1.427
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.561971e-02	1.448
IRS activation	R-HSA-74713	3.795155e-02	1.421
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.795155e-02	1.421
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.795155e-02	1.421
Nectin/Necl trans heterodimerization	R-HSA-420597	3.795155e-02	1.421
Lipophagy	R-HSA-9613354	3.845905e-02	1.415
Unwinding of DNA	R-HSA-176974	3.845905e-02	1.415
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.845905e-02	1.415
Cellular response to mitochondrial stress	R-HSA-9840373	3.845905e-02	1.415
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.866994e-02	1.413
Neutrophil degranulation	R-HSA-6798695	3.872789e-02	1.412
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	3.917122e-02	1.407
Calmodulin induced events	R-HSA-111933	3.952484e-02	1.403
CaM pathway	R-HSA-111997	3.952484e-02	1.403
Signaling by TCF7L2 mutants	R-HSA-5339700	3.989346e-02	1.399
Breakdown of the nuclear lamina	R-HSA-352238	3.989346e-02	1.399
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	4.025370e-02	1.395
Nuclear Receptor transcription pathway	R-HSA-383280	4.031558e-02	1.395
G alpha (12/13) signalling events	R-HSA-416482	4.031558e-02	1.395
IRE1alpha activates chaperones	R-HSA-381070	4.036509e-02	1.394
rRNA processing	R-HSA-72312	4.040502e-02	1.394
Chromatin organization	R-HSA-4839726	4.138212e-02	1.383
G1/S Transition	R-HSA-69206	4.175929e-02	1.379
Vesicle-mediated transport	R-HSA-5653656	4.181309e-02	1.379
Spry regulation of FGF signaling	R-HSA-1295596	5.106383e-02	1.292
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	4.962053e-02	1.304
Long-term potentiation	R-HSA-9620244	4.668168e-02	1.331
ATP-dependent chromatin remodelers	R-HSA-9932444	4.668168e-02	1.331
SWI/SNF chromatin remodelers	R-HSA-9932451	4.668168e-02	1.331
DNA strand elongation	R-HSA-69190	4.897571e-02	1.310
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	4.230383e-02	1.374
Switching of origins to a post-replicative state	R-HSA-69052	4.923724e-02	1.308
PTEN Regulation	R-HSA-6807070	4.242586e-02	1.372
Mitotic Prophase	R-HSA-68875	4.686262e-02	1.329
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	4.874478e-02	1.312
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.256121e-02	1.279
Signaling by ALK in cancer	R-HSA-9700206	4.874478e-02	1.312
Signaling by NTRK1 (TRKA)	R-HSA-187037	5.019884e-02	1.299
Cellular response to chemical stress	R-HSA-9711123	4.594509e-02	1.338
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.512950e-02	1.346
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.450042e-02	1.352
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.897571e-02	1.310
Hedgehog 'off' state	R-HSA-5610787	4.788690e-02	1.320
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.106383e-02	1.292
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	4.316975e-02	1.365
Transcriptional Regulation by TP53	R-HSA-3700989	5.034019e-02	1.298
MITF-M-dependent gene expression	R-HSA-9856651	5.327557e-02	1.273
Myogenesis	R-HSA-525793	5.350843e-02	1.272
RAF/MAP kinase cascade	R-HSA-5673001	5.461302e-02	1.263
DAG and IP3 signaling	R-HSA-1489509	5.518848e-02	1.258
G-protein mediated events	R-HSA-112040	5.550066e-02	1.256
DNA Replication Pre-Initiation	R-HSA-69002	5.552484e-02	1.256
Transcriptional Regulation by E2F6	R-HSA-8953750	5.566648e-02	1.254
KEAP1-NFE2L2 pathway	R-HSA-9755511	5.622101e-02	1.250
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	5.753367e-02	1.240
Signaling by ERBB2	R-HSA-1227986	5.753367e-02	1.240
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	5.928077e-02	1.227
Meiotic synapsis	R-HSA-1221632	5.937018e-02	1.226
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	6.080652e-02	1.216
Prolonged ERK activation events	R-HSA-169893	6.080652e-02	1.216
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.080652e-02	1.216
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	6.088130e-02	1.216
EPHA-mediated growth cone collapse	R-HSA-3928663	6.092839e-02	1.215
HCMV Infection	R-HSA-9609646	6.171661e-02	1.210
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	6.187333e-02	1.208
Opioid Signalling	R-HSA-111885	6.246801e-02	1.204
RNA Polymerase II Transcription Termination	R-HSA-73856	6.264294e-02	1.203
MAP kinase activation	R-HSA-450294	6.264294e-02	1.203
Chromatin modifying enzymes	R-HSA-3247509	6.369834e-02	1.196
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	6.630194e-02	1.178
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	6.630194e-02	1.178
Regulation of cortical dendrite branching	R-HSA-8985801	6.630194e-02	1.178
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	6.630194e-02	1.178
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	6.630194e-02	1.178
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	6.630194e-02	1.178
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	6.630194e-02	1.178
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	6.630194e-02	1.178
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	6.630194e-02	1.178
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	6.630194e-02	1.178
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	6.630194e-02	1.178
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	6.630194e-02	1.178
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	6.630194e-02	1.178
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	6.657734e-02	1.177
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	6.657734e-02	1.177
Signaling by PDGFR in disease	R-HSA-9671555	6.657734e-02	1.177
tRNA processing in the nucleus	R-HSA-6784531	6.804283e-02	1.167
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	6.804283e-02	1.167
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	6.850411e-02	1.164
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	6.932753e-02	1.159
Signaling by LTK in cancer	R-HSA-9842640	6.946769e-02	1.158
Nef and signal transduction	R-HSA-164944	6.946769e-02	1.158
MAPK1/MAPK3 signaling	R-HSA-5684996	7.120453e-02	1.147
Disorders of Developmental Biology	R-HSA-9675151	7.152867e-02	1.146
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	7.219022e-02	1.142
Signaling by PTK6	R-HSA-8848021	7.373687e-02	1.132
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	7.373687e-02	1.132
FasL/ CD95L signaling	R-HSA-75157	9.690991e-02	1.014
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	9.690991e-02	1.014
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	9.690991e-02	1.014
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	9.690991e-02	1.014
SOS-mediated signalling	R-HSA-112412	8.849492e-02	1.053
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	8.849492e-02	1.053
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	8.321686e-02	1.080
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.651523e-02	1.063
Late endosomal microautophagy	R-HSA-9615710	7.756757e-02	1.110
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	9.758456e-02	1.011
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	9.260684e-02	1.033
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.983875e-02	1.098
Ribosome-associated quality control	R-HSA-9948299	9.608666e-02	1.017
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	8.869317e-02	1.052
Synthesis of DNA	R-HSA-69239	7.983875e-02	1.098
Eukaryotic Translation Termination	R-HSA-72764	9.542456e-02	1.020
Oncogene Induced Senescence	R-HSA-2559585	7.710851e-02	1.113
Signalling to ERKs	R-HSA-187687	7.710851e-02	1.113
RNA Polymerase I Transcription Initiation	R-HSA-73762	8.305106e-02	1.081
MTOR signalling	R-HSA-165159	8.305106e-02	1.081
MAPK family signaling cascades	R-HSA-5683057	9.330853e-02	1.030
Rab regulation of trafficking	R-HSA-9007101	9.929685e-02	1.003
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	8.651523e-02	1.063
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	8.168856e-02	1.088
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	7.750164e-02	1.111
HIV Infection	R-HSA-162906	9.473614e-02	1.023
Developmental Biology	R-HSA-1266738	9.049653e-02	1.043
Uptake and function of diphtheria toxin	R-HSA-5336415	8.849492e-02	1.053
Metabolism of non-coding RNA	R-HSA-194441	9.766319e-02	1.010
snRNP Assembly	R-HSA-191859	9.766319e-02	1.010
Sensory processing of sound	R-HSA-9659379	7.750164e-02	1.111
SARS-CoV-2-host interactions	R-HSA-9705683	9.842505e-02	1.007
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.702370e-02	1.113
Epigenetic regulation of gene expression	R-HSA-212165	9.957718e-02	1.002
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.006311e-01	0.997
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.028522e-01	0.988
Signaling by WNT	R-HSA-195721	1.028792e-01	0.988
ER to Golgi Anterograde Transport	R-HSA-199977	1.041682e-01	0.982
Frs2-mediated activation	R-HSA-170968	1.045659e-01	0.981
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.045659e-01	0.981
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.074894e-01	0.969
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	1.076594e-01	0.968
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.080884e-01	0.966
Nucleosome assembly	R-HSA-774815	1.080884e-01	0.966
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.080884e-01	0.966
Signaling by NTRKs	R-HSA-166520	1.090386e-01	0.962
TGFBR3 expression	R-HSA-9839394	1.093673e-01	0.961
Type I hemidesmosome assembly	R-HSA-446107	1.094373e-01	0.961
Signaling by MRAS-complex mutants	R-HSA-9660537	1.094373e-01	0.961
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.094373e-01	0.961
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.094373e-01	0.961
G2/M Checkpoints	R-HSA-69481	1.141886e-01	0.942
Cellular response to starvation	R-HSA-9711097	1.170523e-01	0.932
Integrin signaling	R-HSA-354192	1.179747e-01	0.928
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.179747e-01	0.928
p75 NTR receptor-mediated signalling	R-HSA-193704	1.198772e-01	0.921
TCF dependent signaling in response to WNT	R-HSA-201681	1.199525e-01	0.921
NCAM signaling for neurite out-growth	R-HSA-375165	1.212920e-01	0.916
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	1.216281e-01	0.915
Interleukin-17 signaling	R-HSA-448424	1.219539e-01	0.914
RNA Polymerase I Transcription	R-HSA-73864	1.220167e-01	0.914
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.238071e-01	0.907
Signal transduction by L1	R-HSA-445144	1.238071e-01	0.907
Assembly of the pre-replicative complex	R-HSA-68867	1.278389e-01	0.893
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.295066e-01	0.888
rRNA modification in the nucleus and cytosol	R-HSA-6790901	1.298208e-01	0.887
Regulation of gap junction activity	R-HSA-191650	1.306263e-01	0.884
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.306263e-01	0.884
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.306263e-01	0.884
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.306263e-01	0.884
Signaling by MAP2K mutants	R-HSA-9652169	1.306263e-01	0.884
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.306263e-01	0.884
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.306263e-01	0.884
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	1.306263e-01	0.884
Signaling by Interleukins	R-HSA-449147	1.308696e-01	0.883
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.320715e-01	0.879
Inactivation of CDC42 and RAC1	R-HSA-428543	1.320715e-01	0.879
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.320715e-01	0.879
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.320715e-01	0.879
Selenocysteine synthesis	R-HSA-2408557	1.333716e-01	0.875
Interaction between L1 and Ankyrins	R-HSA-445095	1.349831e-01	0.870
Signaling by FGFR2	R-HSA-5654738	1.376094e-01	0.861
Ion homeostasis	R-HSA-5578775	1.382579e-01	0.859
TNF signaling	R-HSA-75893	1.382579e-01	0.859
NRAGE signals death through JNK	R-HSA-193648	1.382579e-01	0.859
Transcriptional regulation by small RNAs	R-HSA-5578749	1.383911e-01	0.859
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.383911e-01	0.859
Ion transport by P-type ATPases	R-HSA-936837	1.386683e-01	0.858
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.390497e-01	0.857
Activation, translocation and oligomerization of BAX	R-HSA-114294	1.884376e-01	0.725
Diseases of Telomere Maintenance	R-HSA-9673013	1.884376e-01	0.725
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.884376e-01	0.725
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.884376e-01	0.725
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.884376e-01	0.725
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.884376e-01	0.725
TICAM1 deficiency - HSE	R-HSA-5602566	1.884376e-01	0.725
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	1.884376e-01	0.725
Hereditary fructose intolerance	R-HSA-5657560	1.884376e-01	0.725
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	1.884376e-01	0.725
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.884376e-01	0.725
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.038704e-01	0.691
CDC6 association with the ORC:origin complex	R-HSA-68689	2.038704e-01	0.691
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.038704e-01	0.691
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	2.038704e-01	0.691
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	1.561656e-01	0.806
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.814865e-01	0.741
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.814865e-01	0.741
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.814865e-01	0.741
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.397896e-01	0.855
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.589525e-01	0.799
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	2.078051e-01	0.682
ERKs are inactivated	R-HSA-202670	2.078051e-01	0.682
Signaling by GSK3beta mutants	R-HSA-5339716	2.078051e-01	0.682
G beta:gamma signalling through CDC42	R-HSA-8964616	1.790126e-01	0.747
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	1.790126e-01	0.747
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.998624e-01	0.699
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.998624e-01	0.699
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.998624e-01	0.699
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.718044e-01	0.765
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.415788e-01	0.849
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.780871e-01	0.749
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.071915e-01	0.684
G0 and Early G1	R-HSA-1538133	2.095191e-01	0.679
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.424177e-01	0.846
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.980383e-01	0.703
DNA Damage Bypass	R-HSA-73893	1.472998e-01	0.832
EGFR Transactivation by Gastrin	R-HSA-2179392	1.561656e-01	0.806
Josephin domain DUBs	R-HSA-5689877	1.561656e-01	0.806
DCC mediated attractive signaling	R-HSA-418885	1.397896e-01	0.855
Protein ubiquitination	R-HSA-8852135	1.651572e-01	0.782
Muscarinic acetylcholine receptors	R-HSA-390648	1.665349e-01	0.778
MET activates RAP1 and RAC1	R-HSA-8875555	1.561656e-01	0.806
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.541704e-01	0.812
Diseases of mitotic cell cycle	R-HSA-9675126	2.095191e-01	0.679
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	1.892000e-01	0.723
Platelet calcium homeostasis	R-HSA-418360	1.631407e-01	0.787
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.672579e-01	0.777
Trafficking of AMPA receptors	R-HSA-399719	1.935604e-01	0.713
Interleukin-2 signaling	R-HSA-9020558	1.814865e-01	0.741
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.785827e-01	0.748
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.078051e-01	0.682
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.771084e-01	0.752
Meiosis	R-HSA-1500620	1.810430e-01	0.742
DNA Replication	R-HSA-69306	1.896740e-01	0.722
Intracellular signaling by second messengers	R-HSA-9006925	1.727308e-01	0.763
Reduction of cytosolic Ca++ levels	R-HSA-418359	2.078051e-01	0.682
Fanconi Anemia Pathway	R-HSA-6783310	1.942673e-01	0.712
TBC/RABGAPs	R-HSA-8854214	1.690044e-01	0.772
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.706864e-01	0.768
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	2.038704e-01	0.691
Oxidative Stress Induced Senescence	R-HSA-2559580	1.404307e-01	0.853
Cellular responses to mechanical stimuli	R-HSA-9855142	1.748797e-01	0.757
Protein methylation	R-HSA-8876725	1.397896e-01	0.855
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.442046e-01	0.841
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.631407e-01	0.787
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.470374e-01	0.833
Formation of editosomes by ADAR proteins	R-HSA-77042	1.884376e-01	0.725
Signaling by APC mutants	R-HSA-4839744	1.814865e-01	0.741
Signaling by AXIN mutants	R-HSA-4839735	2.078051e-01	0.682
Signaling by AMER1 mutants	R-HSA-4839748	2.078051e-01	0.682
Orc1 removal from chromatin	R-HSA-68949	1.807576e-01	0.743
HIV Life Cycle	R-HSA-162587	1.591619e-01	0.798
Integration of energy metabolism	R-HSA-163685	1.847748e-01	0.733
Signaling by Nuclear Receptors	R-HSA-9006931	1.868817e-01	0.728
TP53 Regulates Metabolic Genes	R-HSA-5628897	1.907707e-01	0.719
Suppression of apoptosis	R-HSA-9635465	1.814865e-01	0.741
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.550675e-01	0.809
Regulation of TP53 Activity	R-HSA-5633007	1.783179e-01	0.749
Heme signaling	R-HSA-9707616	2.015792e-01	0.696
Transmission across Chemical Synapses	R-HSA-112315	1.673231e-01	0.776
Regulation of TNFR1 signaling	R-HSA-5357905	2.074528e-01	0.683
Signaling by TGFB family members	R-HSA-9006936	1.783179e-01	0.749
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.038704e-01	0.691
Protein-protein interactions at synapses	R-HSA-6794362	1.810430e-01	0.742
Signaling by Hedgehog	R-HSA-5358351	1.995942e-01	0.700
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.038704e-01	0.691
Regulation of gene expression in beta cells	R-HSA-210745	1.631407e-01	0.787
RET signaling	R-HSA-8853659	1.672579e-01	0.777
MyD88-independent TLR4 cascade	R-HSA-166166	2.127661e-01	0.672
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.127661e-01	0.672
Viral mRNA Translation	R-HSA-192823	2.183842e-01	0.661
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	2.209772e-01	0.656
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.213926e-01	0.655
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	2.240260e-01	0.650
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	2.240260e-01	0.650
Nuclear signaling by ERBB4	R-HSA-1251985	2.240260e-01	0.650
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.241998e-01	0.649
HDMs demethylate histones	R-HSA-3214842	2.257137e-01	0.646
Interleukin-7 signaling	R-HSA-1266695	2.257137e-01	0.646
G-protein beta:gamma signalling	R-HSA-397795	2.259198e-01	0.646
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.259198e-01	0.646
Nuclear RNA decay	R-HSA-9930044	2.259198e-01	0.646
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	2.259198e-01	0.646
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.259198e-01	0.646
Response of endothelial cells to shear stress	R-HSA-9860931	2.277708e-01	0.643
Signaling by EGFR	R-HSA-177929	2.300395e-01	0.638
Detoxification of Reactive Oxygen Species	R-HSA-3299685	2.300395e-01	0.638
Interferon gamma signaling	R-HSA-877300	2.337336e-01	0.631
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	2.349012e-01	0.629
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.349012e-01	0.629
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.349012e-01	0.629
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.349012e-01	0.629
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.349012e-01	0.629
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.349012e-01	0.629
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.349012e-01	0.629
Repression of WNT target genes	R-HSA-4641265	2.349012e-01	0.629
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.349012e-01	0.629
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	2.349012e-01	0.629
Disorders of Nervous System Development	R-HSA-9697154	2.349012e-01	0.629
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	2.349012e-01	0.629
Pervasive developmental disorders	R-HSA-9005895	2.349012e-01	0.629
Late Phase of HIV Life Cycle	R-HSA-162599	2.390117e-01	0.622
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.390117e-01	0.622
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.391725e-01	0.621
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.391725e-01	0.621
Transcriptional Regulation by VENTX	R-HSA-8853884	2.391725e-01	0.621
FLT3 Signaling	R-HSA-9607240	2.391725e-01	0.621
Defective HK1 causes hexokinase deficiency (HK deficiency)	R-HSA-5619056	2.688968e-01	0.570
TRAF3 deficiency - HSE	R-HSA-5602571	2.688968e-01	0.570
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	2.688968e-01	0.570
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.688968e-01	0.570
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.688968e-01	0.570
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.413835e-01	0.467
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.413835e-01	0.467
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.413835e-01	0.467
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.413835e-01	0.467
Signaling by RAS GAP mutants	R-HSA-9753510	3.413835e-01	0.467
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.419975e-01	0.616
Autointegration results in viral DNA circles	R-HSA-177539	2.419975e-01	0.616
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	2.419975e-01	0.616
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	2.419975e-01	0.616
TRIF-mediated programmed cell death	R-HSA-2562578	2.803927e-01	0.552
Recycling of eIF2:GDP	R-HSA-72731	2.803927e-01	0.552
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.066872e-01	0.391
Defective GSS causes GSS deficiency	R-HSA-5579006	4.066872e-01	0.391
Invadopodia formation	R-HSA-8941237	4.066872e-01	0.391
Defective ABCC2 causes DJS	R-HSA-5679001	4.066872e-01	0.391
Regulation by c-FLIP	R-HSA-3371378	3.186286e-01	0.497
Dimerization of procaspase-8	R-HSA-69416	3.186286e-01	0.497
phospho-PLA2 pathway	R-HSA-111995	3.186286e-01	0.497
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	3.186286e-01	0.497
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.186286e-01	0.497
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.625656e-01	0.581
ARMS-mediated activation	R-HSA-170984	3.563595e-01	0.448
WNT mediated activation of DVL	R-HSA-201688	3.563595e-01	0.448
MAPK1 (ERK2) activation	R-HSA-112411	3.563595e-01	0.448
CASP8 activity is inhibited	R-HSA-5218900	3.563595e-01	0.448
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.655193e-01	0.332
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.655193e-01	0.332
Defective LFNG causes SCDO3	R-HSA-5083630	4.655193e-01	0.332
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.655193e-01	0.332
Regulation of PD-L1(CD274) translation	R-HSA-9909620	2.660578e-01	0.575
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	2.660578e-01	0.575
Erythropoietin activates RAS	R-HSA-9027284	3.188331e-01	0.496
Processive synthesis on the lagging strand	R-HSA-69183	3.188331e-01	0.496
p38MAPK events	R-HSA-171007	3.188331e-01	0.496
IRF3-mediated induction of type I IFN	R-HSA-3270619	3.188331e-01	0.496
Beta-catenin phosphorylation cascade	R-HSA-196299	3.188331e-01	0.496
G beta:gamma signalling through BTK	R-HSA-8964315	3.188331e-01	0.496
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.889794e-01	0.539
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.889794e-01	0.539
Lagging Strand Synthesis	R-HSA-69186	2.889794e-01	0.539
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.933100e-01	0.405
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.427179e-01	0.615
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	3.470909e-01	0.460
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	3.470909e-01	0.460
Class I peroxisomal membrane protein import	R-HSA-9603798	3.470909e-01	0.460
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	3.470909e-01	0.460
Phosphorylation of the APC/C	R-HSA-176412	3.470909e-01	0.460
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.121568e-01	0.506
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.838000e-01	0.547
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	2.598679e-01	0.585
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.037805e-01	0.517
Negative regulation of FGFR4 signaling	R-HSA-5654733	3.037805e-01	0.517
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.752277e-01	0.426
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	4.292640e-01	0.367
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	4.292640e-01	0.367
Formation of RNA Pol II elongation complex	R-HSA-112382	2.928172e-01	0.533
Deadenylation of mRNA	R-HSA-429947	3.822773e-01	0.418
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	4.640560e-01	0.333
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.078465e-01	0.512
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.078465e-01	0.512
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	3.492868e-01	0.457
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.306224e-01	0.366
G beta:gamma signalling through PLC beta	R-HSA-418217	4.306224e-01	0.366
mRNA Splicing - Minor Pathway	R-HSA-72165	3.355270e-01	0.474
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	3.355270e-01	0.474
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.689132e-01	0.433
Signaling by EGFR in Cancer	R-HSA-1643713	4.286651e-01	0.368
Regulation of signaling by CBL	R-HSA-912631	4.576606e-01	0.339
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	4.576606e-01	0.339
Negative regulation of FGFR2 signaling	R-HSA-5654727	4.257645e-01	0.371
Dual Incision in GG-NER	R-HSA-5696400	4.257645e-01	0.371
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.360088e-01	0.361
PRC2 methylates histones and DNA	R-HSA-212300	4.658917e-01	0.332
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.505776e-01	0.455
Signaling by ERBB2 in Cancer	R-HSA-1227990	3.239616e-01	0.490
Negative regulation of FGFR1 signaling	R-HSA-5654726	3.850927e-01	0.414
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	3.189869e-01	0.496
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	3.189869e-01	0.496
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.673978e-01	0.435
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.189869e-01	0.496
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	4.286651e-01	0.368
Chromosome Maintenance	R-HSA-73886	3.394597e-01	0.469
Nucleotide Excision Repair	R-HSA-5696398	4.485469e-01	0.348
Rap1 signalling	R-HSA-392517	2.434937e-01	0.614
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.239616e-01	0.490
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.239616e-01	0.490
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	4.768269e-01	0.322
GAB1 signalosome	R-HSA-180292	4.306224e-01	0.366
Adipogenesis	R-HSA-9843745	4.674069e-01	0.330
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.906031e-01	0.537
Co-inhibition by CTLA4	R-HSA-389513	2.660578e-01	0.575
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.447004e-01	0.611
Regulation of CDH11 function	R-HSA-9762292	3.933100e-01	0.405
PI3K/AKT activation	R-HSA-198203	3.933100e-01	0.405
Elevation of cytosolic Ca2+ levels	R-HSA-139853	4.031106e-01	0.395
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.640560e-01	0.333
Formation of Incision Complex in GG-NER	R-HSA-5696395	3.675880e-01	0.435
HATs acetylate histones	R-HSA-3214847	4.783840e-01	0.320
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	2.447004e-01	0.611
Sodium/Proton exchangers	R-HSA-425986	3.186286e-01	0.497
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.186286e-01	0.497
Translesion Synthesis by POLH	R-HSA-110320	2.434937e-01	0.614
MAPK3 (ERK1) activation	R-HSA-110056	3.933100e-01	0.405
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	3.230339e-01	0.491
Cyclin E associated events during G1/S transition	R-HSA-69202	3.009382e-01	0.522
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.371974e-01	0.359
Clathrin-mediated endocytosis	R-HSA-8856828	2.472702e-01	0.607
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.273775e-01	0.369
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.286651e-01	0.368
PIP3 activates AKT signaling	R-HSA-1257604	3.780499e-01	0.422
Integration of provirus	R-HSA-162592	4.640560e-01	0.333
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.515283e-01	0.345
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.526736e-01	0.344
NoRC negatively regulates rRNA expression	R-HSA-427413	4.419506e-01	0.355
Ca2+ pathway	R-HSA-4086398	3.410935e-01	0.467
Deadenylation-dependent mRNA decay	R-HSA-429914	4.004143e-01	0.397
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.773237e-01	0.557
Formation of definitive endoderm	R-HSA-9823730	2.660578e-01	0.575
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	3.239616e-01	0.490
Translation	R-HSA-72766	3.469739e-01	0.460
Formation of the posterior neural plate	R-HSA-9832991	4.292640e-01	0.367
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.489463e-01	0.604
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.239616e-01	0.490
Glucagon signaling in metabolic regulation	R-HSA-163359	4.054726e-01	0.392
Defective pyroptosis	R-HSA-9710421	4.407730e-01	0.356
Extra-nuclear estrogen signaling	R-HSA-9009391	2.859124e-01	0.544
DNA Double-Strand Break Repair	R-HSA-5693532	4.237151e-01	0.373
Circadian clock	R-HSA-9909396	2.896797e-01	0.538
Beta-catenin independent WNT signaling	R-HSA-3858494	2.545067e-01	0.594
mTORC1-mediated signalling	R-HSA-166208	3.354927e-01	0.474
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.835928e-01	0.547
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.835928e-01	0.547
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.835928e-01	0.547
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.835928e-01	0.547
Platelet activation, signaling and aggregation	R-HSA-76002	2.969119e-01	0.527
Activation of BAD and translocation to mitochondria	R-HSA-111447	3.188331e-01	0.496
WNT5A-dependent internalization of FZD4	R-HSA-5099900	3.470909e-01	0.460
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	4.031106e-01	0.395
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	4.576606e-01	0.339
Regulation of RAS by GAPs	R-HSA-5658442	4.024899e-01	0.395
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.055587e-01	0.392
Homology Directed Repair	R-HSA-5693538	4.061142e-01	0.391
ROBO receptors bind AKAP5	R-HSA-9010642	3.186286e-01	0.497
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	3.822773e-01	0.418
TRP channels	R-HSA-3295583	4.286651e-01	0.368
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.990826e-01	0.524
Signaling by WNT in cancer	R-HSA-4791275	3.646770e-01	0.438
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	2.434937e-01	0.614
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.822773e-01	0.418
G1/S DNA Damage Checkpoints	R-HSA-69615	3.257702e-01	0.487
PCP/CE pathway	R-HSA-4086400	4.096298e-01	0.388
Ub-specific processing proteases	R-HSA-5689880	3.594529e-01	0.444
Regulation of necroptotic cell death	R-HSA-5675482	3.850927e-01	0.414
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.817455e-01	0.550
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.688968e-01	0.570
Transport of connexins along the secretory pathway	R-HSA-190827	2.688968e-01	0.570
Manipulation of host energy metabolism	R-HSA-9636667	2.688968e-01	0.570
mRNA Editing: A to I Conversion	R-HSA-75064	3.413835e-01	0.467
C6 deamination of adenosine	R-HSA-75102	3.413835e-01	0.467
Cation-coupled Chloride cotransporters	R-HSA-426117	2.803927e-01	0.552
Regulation of PTEN localization	R-HSA-8948747	2.803927e-01	0.552
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	4.066872e-01	0.391
MET interacts with TNS proteins	R-HSA-8875513	4.066872e-01	0.391
Membrane binding and targetting of GAG proteins	R-HSA-174490	2.625656e-01	0.581
The NLRP3 inflammasome	R-HSA-844456	2.434937e-01	0.614
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.563595e-01	0.448
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	3.563595e-01	0.448
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	3.563595e-01	0.448
VxPx cargo-targeting to cilium	R-HSA-5620916	2.660578e-01	0.575
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.933100e-01	0.405
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	3.933100e-01	0.405
Phase 0 - rapid depolarisation	R-HSA-5576892	2.838000e-01	0.547
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.752277e-01	0.426
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	4.306224e-01	0.366
Presynaptic function of Kainate receptors	R-HSA-500657	4.306224e-01	0.366
E2F mediated regulation of DNA replication	R-HSA-113510	4.576606e-01	0.339
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.225578e-01	0.374
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	4.646518e-01	0.333
Signaling by NOTCH	R-HSA-157118	3.152542e-01	0.501
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	4.371974e-01	0.359
Platelet degranulation	R-HSA-114608	3.185319e-01	0.497
Deubiquitination	R-HSA-5688426	2.919846e-01	0.535
Gene expression (Transcription)	R-HSA-74160	3.868927e-01	0.412
Neurexins and neuroligins	R-HSA-6794361	2.928172e-01	0.533
Atorvastatin ADME	R-HSA-9754706	3.470909e-01	0.460
Signaling by FGFR4	R-HSA-5654743	4.407730e-01	0.356
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	2.906031e-01	0.537
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	2.660578e-01	0.575
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	3.188331e-01	0.496
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.354927e-01	0.474
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	3.848327e-01	0.415
Signaling by FGFR3	R-HSA-5654741	4.768269e-01	0.322
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.189869e-01	0.496
Azathioprine ADME	R-HSA-9748787	4.024899e-01	0.395
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.835928e-01	0.547
Signaling by NOTCH1	R-HSA-1980143	3.820807e-01	0.418
Netrin-1 signaling	R-HSA-373752	3.025936e-01	0.519
Regulation of NPAS4 gene expression	R-HSA-9768759	4.031106e-01	0.395
PERK regulates gene expression	R-HSA-381042	4.459194e-01	0.351
Signaling by ERBB4	R-HSA-1236394	2.428875e-01	0.615
Oligomerization of connexins into connexons	R-HSA-190704	2.688968e-01	0.570
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.419975e-01	0.616
Intracellular oxygen transport	R-HSA-8981607	4.066872e-01	0.391
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	3.563595e-01	0.448
NADE modulates death signalling	R-HSA-205025	4.655193e-01	0.332
TNFR1-mediated ceramide production	R-HSA-5626978	4.655193e-01	0.332
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	3.188331e-01	0.496
2-LTR circle formation	R-HSA-164843	3.933100e-01	0.405
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.752277e-01	0.426
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.292640e-01	0.367
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.640560e-01	0.333
Viral Messenger RNA Synthesis	R-HSA-168325	2.974960e-01	0.527
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	3.958445e-01	0.402
Hemostasis	R-HSA-109582	3.438129e-01	0.464
Neuronal System	R-HSA-112316	3.563861e-01	0.448
MyD88 cascade initiated on plasma membrane	R-HSA-975871	4.659814e-01	0.332
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	4.659814e-01	0.332
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	4.659814e-01	0.332
Inflammasomes	R-HSA-622312	4.740864e-01	0.324
Reproduction	R-HSA-1474165	4.566946e-01	0.340
STING mediated induction of host immune responses	R-HSA-1834941	4.576606e-01	0.339
Biotin transport and metabolism	R-HSA-196780	3.188331e-01	0.496
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.447004e-01	0.611
Regulation of PTEN stability and activity	R-HSA-8948751	4.526736e-01	0.344
Potential therapeutics for SARS	R-HSA-9679191	3.080287e-01	0.511
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	3.933100e-01	0.405
Gluconeogenesis	R-HSA-70263	3.689132e-01	0.433
Neurofascin interactions	R-HSA-447043	2.419975e-01	0.616
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	3.188331e-01	0.496
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	3.354927e-01	0.474
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	2.640847e-01	0.578
Signaling by FGFR	R-HSA-190236	3.531135e-01	0.452
Syndecan interactions	R-HSA-3000170	3.588951e-01	0.445
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	4.042634e-01	0.393
NTRK3 as a dependence receptor	R-HSA-9603505	2.688968e-01	0.570
MECP2 regulates transcription factors	R-HSA-9022707	2.803927e-01	0.552
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.655193e-01	0.332
Dopamine receptors	R-HSA-390651	4.655193e-01	0.332
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.933100e-01	0.405
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	3.121568e-01	0.506
Downstream signal transduction	R-HSA-186763	3.442806e-01	0.463
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	2.546493e-01	0.594
Zinc transporters	R-HSA-435354	2.906031e-01	0.537
Viral Infection Pathways	R-HSA-9824446	4.323031e-01	0.364
Platelet sensitization by LDL	R-HSA-432142	4.306224e-01	0.366
Regulation of CDH11 gene transcription	R-HSA-9762293	3.563595e-01	0.448
G1/S-Specific Transcription	R-HSA-69205	2.950392e-01	0.530
Maturation of nucleoprotein	R-HSA-9694631	4.576606e-01	0.339
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.803927e-01	0.552
Respiratory syncytial virus genome replication	R-HSA-9834752	3.563595e-01	0.448
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.292640e-01	0.367
Signaling by NOTCH4	R-HSA-9013694	3.546874e-01	0.450
Gene Silencing by RNA	R-HSA-211000	4.724118e-01	0.326
Transcriptional Regulation by NPAS4	R-HSA-9634815	4.360088e-01	0.361
Regulation of the apoptosome activity	R-HSA-9627069	3.933100e-01	0.405
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	2.598679e-01	0.585
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	3.752277e-01	0.426
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.230339e-01	0.491
SARS-CoV-1-host interactions	R-HSA-9692914	2.568975e-01	0.590
Specification of primordial germ cells	R-HSA-9827857	4.031106e-01	0.395
Selenoamino acid metabolism	R-HSA-2408522	4.393063e-01	0.357
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	4.292640e-01	0.367
Signaling by ALK	R-HSA-201556	3.492868e-01	0.457
Regulation of beta-cell development	R-HSA-186712	4.004143e-01	0.397
Apoptotic factor-mediated response	R-HSA-111471	4.306224e-01	0.366
Signaling by Leptin	R-HSA-2586552	3.933100e-01	0.405
Formation of apoptosome	R-HSA-111458	3.933100e-01	0.405
Cytochrome c-mediated apoptotic response	R-HSA-111461	4.640560e-01	0.333
Growth hormone receptor signaling	R-HSA-982772	3.588951e-01	0.445
Negative regulation of MET activity	R-HSA-6807004	4.841370e-01	0.315
Glycogen synthesis	R-HSA-3322077	4.841370e-01	0.315
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	4.842866e-01	0.315
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.853289e-01	0.314
G alpha (z) signalling events	R-HSA-418597	4.856794e-01	0.314
Signaling by NOTCH3	R-HSA-9012852	4.856794e-01	0.314
ABC-family proteins mediated transport	R-HSA-382556	4.907326e-01	0.309
SARS-CoV-2 Infection	R-HSA-9694516	4.909327e-01	0.309
Developmental Cell Lineages	R-HSA-9734767	4.911898e-01	0.309
Signaling by TGFBR3	R-HSA-9839373	4.946011e-01	0.306
MyD88 dependent cascade initiated on endosome	R-HSA-975155	4.961098e-01	0.304
Glucagon-type ligand receptors	R-HSA-420092	4.962841e-01	0.304
RUNX3 regulates p14-ARF	R-HSA-8951936	4.975629e-01	0.303
Polymerase switching	R-HSA-69091	4.975629e-01	0.303
Maple Syrup Urine Disease	R-HSA-9865114	4.975629e-01	0.303
Leading Strand Synthesis	R-HSA-69109	4.975629e-01	0.303
Scavenging by Class F Receptors	R-HSA-3000484	4.975629e-01	0.303
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.975629e-01	0.303
GRB2 events in EGFR signaling	R-HSA-179812	4.975629e-01	0.303
VLDLR internalisation and degradation	R-HSA-8866427	4.975629e-01	0.303
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	4.975629e-01	0.303
p75NTR recruits signalling complexes	R-HSA-209543	4.975629e-01	0.303
Mitochondrial biogenesis	R-HSA-1592230	5.010591e-01	0.300
Transcriptional regulation by RUNX1	R-HSA-8878171	5.014074e-01	0.300
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.019705e-01	0.299
Intrinsic Pathway for Apoptosis	R-HSA-109606	5.019705e-01	0.299
MET promotes cell motility	R-HSA-8875878	5.051227e-01	0.297
RIPK1-mediated regulated necrosis	R-HSA-5213460	5.051227e-01	0.297
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.099768e-01	0.292
PKA-mediated phosphorylation of CREB	R-HSA-111931	5.099768e-01	0.292
G-protein activation	R-HSA-202040	5.099768e-01	0.292
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	5.099768e-01	0.292
Signalling to RAS	R-HSA-167044	5.099768e-01	0.292
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	5.099768e-01	0.292
Basigin interactions	R-HSA-210991	5.099768e-01	0.292
Early Phase of HIV Life Cycle	R-HSA-162594	5.099768e-01	0.292
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	5.121674e-01	0.291
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.121674e-01	0.291
Activation of BH3-only proteins	R-HSA-114452	5.180718e-01	0.286
Interleukin-37 signaling	R-HSA-9008059	5.180718e-01	0.286
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	5.180895e-01	0.286
NrCAM interactions	R-HSA-447038	5.185208e-01	0.285
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.185208e-01	0.285
FLT3 signaling by CBL mutants	R-HSA-9706377	5.185208e-01	0.285
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.185208e-01	0.285
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.185208e-01	0.285
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.185208e-01	0.285
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.185208e-01	0.285
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	5.185208e-01	0.285
Assembly of Viral Components at the Budding Site	R-HSA-168316	5.185208e-01	0.285
SARS-CoV Infections	R-HSA-9679506	5.248513e-01	0.280
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	5.294988e-01	0.276
Co-stimulation by CD28	R-HSA-389356	5.294988e-01	0.276
NGF-stimulated transcription	R-HSA-9031628	5.294988e-01	0.276
Metal ion SLC transporters	R-HSA-425410	5.294988e-01	0.276
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.296977e-01	0.276
Formation of axial mesoderm	R-HSA-9796292	5.296977e-01	0.276
Interleukin-6 signaling	R-HSA-1059683	5.296977e-01	0.276
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.296977e-01	0.276
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	5.296977e-01	0.276
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	5.296977e-01	0.276
Maturation of nucleoprotein	R-HSA-9683610	5.296977e-01	0.276
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.296977e-01	0.276
Inositol phosphate metabolism	R-HSA-1483249	5.311752e-01	0.275
Transport to the Golgi and subsequent modification	R-HSA-948021	5.341637e-01	0.272
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	5.351176e-01	0.272
Listeria monocytogenes entry into host cells	R-HSA-8876384	5.351176e-01	0.272
Ribavirin ADME	R-HSA-9755088	5.351176e-01	0.272
Signaling by NTRK3 (TRKC)	R-HSA-9034015	5.351176e-01	0.272
Assembly Of The HIV Virion	R-HSA-175474	5.351176e-01	0.272
EGFR downregulation	R-HSA-182971	5.394062e-01	0.268
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	5.394062e-01	0.268
Budding and maturation of HIV virion	R-HSA-162588	5.394062e-01	0.268
Evasion by RSV of host interferon responses	R-HSA-9833109	5.394062e-01	0.268
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.426991e-01	0.265
Negative regulation of NOTCH4 signaling	R-HSA-9604323	5.431605e-01	0.265
Degradation of CDH1	R-HSA-9766229	5.465707e-01	0.262
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	5.497279e-01	0.260
SARS-CoV-1 Infection	R-HSA-9678108	5.526215e-01	0.258
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.541268e-01	0.256
RAF-independent MAPK1/3 activation	R-HSA-112409	5.595086e-01	0.252
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	5.595086e-01	0.252
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.595086e-01	0.252
LDL clearance	R-HSA-8964038	5.595086e-01	0.252
Removal of the Flap Intermediate	R-HSA-69166	5.604029e-01	0.251
Retrograde neurotrophin signalling	R-HSA-177504	5.604029e-01	0.251
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.604029e-01	0.251
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	5.604029e-01	0.251
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77350	5.604029e-01	0.251
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77348	5.604029e-01	0.251
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77310	5.604029e-01	0.251
Regulation of KIT signaling	R-HSA-1433559	5.604029e-01	0.251
Signal regulatory protein family interactions	R-HSA-391160	5.604029e-01	0.251
Acyl chain remodeling of CL	R-HSA-1482798	5.604029e-01	0.251
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.616540e-01	0.251
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.616540e-01	0.251
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	5.642360e-01	0.249
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.662693e-01	0.247
Noncanonical activation of NOTCH3	R-HSA-9017802	5.662693e-01	0.247
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.662693e-01	0.247
Phosphorylation of Emi1	R-HSA-176417	5.662693e-01	0.247
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.662693e-01	0.247
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	5.662693e-01	0.247
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	5.662693e-01	0.247
Signaling by MAPK mutants	R-HSA-9652817	5.662693e-01	0.247
TRAIL signaling	R-HSA-75158	5.662693e-01	0.247
Release of apoptotic factors from the mitochondria	R-HSA-111457	5.662693e-01	0.247
Pentose phosphate pathway disease	R-HSA-6791465	5.662693e-01	0.247
Signalling to p38 via RIT and RIN	R-HSA-187706	5.662693e-01	0.247
Signaling by MET	R-HSA-6806834	5.690546e-01	0.245
Platelet homeostasis	R-HSA-418346	5.747955e-01	0.240
RNA Polymerase II Transcription	R-HSA-73857	5.753532e-01	0.240
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.766619e-01	0.239
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	5.797623e-01	0.237
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.805695e-01	0.236
Regulation of mitotic cell cycle	R-HSA-453276	5.813467e-01	0.236
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.813467e-01	0.236
Regulation of T cell activation by CD28 family	R-HSA-388841	5.861914e-01	0.232
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	5.896461e-01	0.229
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	5.896461e-01	0.229
SHC1 events in EGFR signaling	R-HSA-180336	5.896461e-01	0.229
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.896461e-01	0.229
Translesion synthesis by REV1	R-HSA-110312	5.896461e-01	0.229
Telomere C-strand synthesis initiation	R-HSA-174430	5.896461e-01	0.229
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.896461e-01	0.229
Formation of the anterior neural plate	R-HSA-9823739	5.896461e-01	0.229
p75NTR signals via NF-kB	R-HSA-193639	5.896461e-01	0.229
Signaling by Activin	R-HSA-1502540	5.896461e-01	0.229
trans-Golgi Network Vesicle Budding	R-HSA-199992	5.953492e-01	0.225
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	5.954123e-01	0.225
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.954123e-01	0.225
Signaling by PDGF	R-HSA-186797	5.954123e-01	0.225
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	5.960144e-01	0.225
RNA Polymerase I Promoter Escape	R-HSA-73772	5.960144e-01	0.225
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.961937e-01	0.225
FOXO-mediated transcription	R-HSA-9614085	5.969187e-01	0.224
Cytosolic tRNA aminoacylation	R-HSA-379716	5.974632e-01	0.224
Resolution of D-Loop Structures	R-HSA-5693537	6.003391e-01	0.222
Effects of PIP2 hydrolysis	R-HSA-114508	6.003391e-01	0.222
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.003391e-01	0.222
Co-inhibition by PD-1	R-HSA-389948	6.005988e-01	0.221
Thromboxane signalling through TP receptor	R-HSA-428930	6.058890e-01	0.218
Cytoprotection by HMOX1	R-HSA-9707564	6.086428e-01	0.216
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.092851e-01	0.215
Erythropoietin activates STAT5	R-HSA-9027283	6.092851e-01	0.215
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.092851e-01	0.215
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.092851e-01	0.215
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	6.092851e-01	0.215
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	6.092851e-01	0.215
G2/M DNA replication checkpoint	R-HSA-69478	6.092851e-01	0.215
Abacavir transmembrane transport	R-HSA-2161517	6.092851e-01	0.215
Regulation of NFE2L2 gene expression	R-HSA-9818749	6.092851e-01	0.215
HDL clearance	R-HSA-8964011	6.092851e-01	0.215
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	6.118439e-01	0.213
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	6.147375e-01	0.211
Response of Mtb to phagocytosis	R-HSA-9637690	6.147375e-01	0.211
Signaling by SCF-KIT	R-HSA-1433557	6.147375e-01	0.211
Translesion synthesis by POLI	R-HSA-5656121	6.174152e-01	0.209
Activation of SMO	R-HSA-5635838	6.174152e-01	0.209
Fructose catabolism	R-HSA-70350	6.174152e-01	0.209
Negative regulation of FLT3	R-HSA-9706369	6.174152e-01	0.209
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.174152e-01	0.209
Signaling by NOTCH2	R-HSA-1980145	6.195362e-01	0.208
Signal amplification	R-HSA-392518	6.195362e-01	0.208
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	6.195362e-01	0.208
NPAS4 regulates expression of target genes	R-HSA-9768919	6.195362e-01	0.208
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.214262e-01	0.207
G2/M DNA damage checkpoint	R-HSA-69473	6.226392e-01	0.206
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.245080e-01	0.204
DNA Repair	R-HSA-73894	6.276890e-01	0.202
G protein gated Potassium channels	R-HSA-1296059	6.278256e-01	0.202
Activation of G protein gated Potassium channels	R-HSA-1296041	6.278256e-01	0.202
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	6.278256e-01	0.202
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.278256e-01	0.202
Tight junction interactions	R-HSA-420029	6.278256e-01	0.202
Acyl chain remodelling of PS	R-HSA-1482801	6.278256e-01	0.202
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.308070e-01	0.200
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.308070e-01	0.200
RMTs methylate histone arginines	R-HSA-3214858	6.315689e-01	0.200
EPHB-mediated forward signaling	R-HSA-3928662	6.315689e-01	0.200
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	6.359062e-01	0.197
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	6.381431e-01	0.195
Regulation of Apoptosis	R-HSA-169911	6.381431e-01	0.195
Cellular response to hypoxia	R-HSA-1234174	6.386106e-01	0.195
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.424368e-01	0.192
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.437149e-01	0.191
Translesion synthesis by POLK	R-HSA-5655862	6.437149e-01	0.191
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.437149e-01	0.191
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.437149e-01	0.191
TRAF3-dependent IRF activation pathway	R-HSA-918233	6.437149e-01	0.191
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	6.437149e-01	0.191
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77346	6.437149e-01	0.191
Acetylcholine regulates insulin secretion	R-HSA-399997	6.437149e-01	0.191
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.437149e-01	0.191
tRNA modification in the mitochondrion	R-HSA-6787450	6.437149e-01	0.191
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	6.479440e-01	0.188
RUNX3 regulates WNT signaling	R-HSA-8951430	6.480370e-01	0.188
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.480370e-01	0.188
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.480370e-01	0.188
Disinhibition of SNARE formation	R-HSA-114516	6.480370e-01	0.188
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.480370e-01	0.188
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.480370e-01	0.188
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.480370e-01	0.188
PTK6 Expression	R-HSA-8849473	6.480370e-01	0.188
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.480370e-01	0.188
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.480370e-01	0.188
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.480370e-01	0.188
VLDL clearance	R-HSA-8964046	6.480370e-01	0.188
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.480370e-01	0.188
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.480370e-01	0.188
CHL1 interactions	R-HSA-447041	6.480370e-01	0.188
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.480370e-01	0.188
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	6.489048e-01	0.188
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	6.489048e-01	0.188
Signaling by FLT3 fusion proteins	R-HSA-9703465	6.489048e-01	0.188
Metalloprotease DUBs	R-HSA-5689901	6.489048e-01	0.188
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.540378e-01	0.184
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	6.561464e-01	0.183
RNA Polymerase III Transcription	R-HSA-74158	6.561464e-01	0.183
Lysosome Vesicle Biogenesis	R-HSA-432720	6.561464e-01	0.183
Regulation of TP53 Degradation	R-HSA-6804757	6.561464e-01	0.183
FLT3 signaling in disease	R-HSA-9682385	6.561464e-01	0.183
RUNX2 regulates bone development	R-HSA-8941326	6.561464e-01	0.183
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	6.571775e-01	0.182
Signaling by FGFR1	R-HSA-5654736	6.571775e-01	0.182
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.584179e-01	0.181
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	6.584179e-01	0.181
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.615536e-01	0.179
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.615536e-01	0.179
DNA Double Strand Break Response	R-HSA-5693606	6.658773e-01	0.177
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.658773e-01	0.177
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.685637e-01	0.175
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.685637e-01	0.175
PI3K events in ERBB2 signaling	R-HSA-1963642	6.685637e-01	0.175
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.685637e-01	0.175
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.685637e-01	0.175
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.691191e-01	0.174
RNA Polymerase I Promoter Opening	R-HSA-73728	6.691191e-01	0.174
Cristae formation	R-HSA-8949613	6.691191e-01	0.174
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	6.691191e-01	0.174
RNA Polymerase I Transcription Termination	R-HSA-73863	6.691191e-01	0.174
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	6.691191e-01	0.174
CD28 dependent PI3K/Akt signaling	R-HSA-389357	6.691191e-01	0.174
Insulin processing	R-HSA-264876	6.691191e-01	0.174
Degradation of DVL	R-HSA-4641258	6.735368e-01	0.172
Ion channel transport	R-HSA-983712	6.738286e-01	0.171
Adaptive Immune System	R-HSA-1280218	6.800963e-01	0.167
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.829474e-01	0.166
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.829474e-01	0.166
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.829474e-01	0.166
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.829474e-01	0.166
Interleukin-9 signaling	R-HSA-8985947	6.829474e-01	0.166
Activation of RAS in B cells	R-HSA-1169092	6.829474e-01	0.166
Downregulation of ERBB4 signaling	R-HSA-1253288	6.829474e-01	0.166
SLC-mediated bile acid transport	R-HSA-9958517	6.829474e-01	0.166
Alpha-defensins	R-HSA-1462054	6.829474e-01	0.166
Adrenoceptors	R-HSA-390696	6.829474e-01	0.166
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	6.829474e-01	0.166
Dual incision in TC-NER	R-HSA-6782135	6.855040e-01	0.164
HIV elongation arrest and recovery	R-HSA-167287	6.884672e-01	0.162
Pausing and recovery of HIV elongation	R-HSA-167290	6.884672e-01	0.162
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	6.884672e-01	0.162
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	6.884672e-01	0.162
Activation of kainate receptors upon glutamate binding	R-HSA-451326	6.884672e-01	0.162
Transcriptional regulation by RUNX3	R-HSA-8878159	6.892764e-01	0.162
PKA activation	R-HSA-163615	6.919904e-01	0.160
PKA activation in glucagon signalling	R-HSA-164378	6.919904e-01	0.160
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.919904e-01	0.160
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.919904e-01	0.160
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.919904e-01	0.160
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.919904e-01	0.160
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.919904e-01	0.160
Mismatch Repair	R-HSA-5358508	6.919904e-01	0.160
Tie2 Signaling	R-HSA-210993	6.919904e-01	0.160
Nephron development	R-HSA-9831926	6.919904e-01	0.160
GPER1 signaling	R-HSA-9634597	6.942353e-01	0.158
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.973740e-01	0.157
Extension of Telomeres	R-HSA-180786	6.990775e-01	0.155
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	7.043263e-01	0.152
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	7.064583e-01	0.151
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	7.064583e-01	0.151
Stabilization of p53	R-HSA-69541	7.064583e-01	0.151
Regulation of TP53 Expression and Degradation	R-HSA-6806003	7.064583e-01	0.151
Pentose phosphate pathway	R-HSA-71336	7.064583e-01	0.151
Plasma lipoprotein clearance	R-HSA-8964043	7.064583e-01	0.151
Signaling by Erythropoietin	R-HSA-9006335	7.069531e-01	0.151
Termination of translesion DNA synthesis	R-HSA-5656169	7.069531e-01	0.151
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	7.069531e-01	0.151
DARPP-32 events	R-HSA-180024	7.069531e-01	0.151
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.087007e-01	0.150
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.087007e-01	0.150
Processing of DNA double-strand break ends	R-HSA-5693607	7.097339e-01	0.149
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	7.097339e-01	0.149
tRNA Aminoacylation	R-HSA-379724	7.122521e-01	0.147
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.140327e-01	0.146
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	7.140327e-01	0.146
Germ layer formation at gastrulation	R-HSA-9754189	7.140327e-01	0.146
Other interleukin signaling	R-HSA-449836	7.140327e-01	0.146
Interleukin-21 signaling	R-HSA-9020958	7.143971e-01	0.146
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.143971e-01	0.146
MASTL Facilitates Mitotic Progression	R-HSA-2465910	7.143971e-01	0.146
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.143971e-01	0.146
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.143971e-01	0.146
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	7.143971e-01	0.146
mRNA Editing	R-HSA-75072	7.143971e-01	0.146
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.143971e-01	0.146
GP1b-IX-V activation signalling	R-HSA-430116	7.143971e-01	0.146
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.143971e-01	0.146
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.143971e-01	0.146
Butyrophilin (BTN) family interactions	R-HSA-8851680	7.143971e-01	0.146
Hedgehog 'on' state	R-HSA-5632684	7.164696e-01	0.145
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.219873e-01	0.141
Generation of second messenger molecules	R-HSA-202433	7.219873e-01	0.141
Regulation of RUNX3 expression and activity	R-HSA-8941858	7.219873e-01	0.141
DAP12 signaling	R-HSA-2424491	7.245855e-01	0.140
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.245855e-01	0.140
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	7.245855e-01	0.140
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.245855e-01	0.140
Transcriptional regulation by RUNX2	R-HSA-8878166	7.310816e-01	0.136
Formation of ATP by chemiosmotic coupling	R-HSA-163210	7.347347e-01	0.134
Protein hydroxylation	R-HSA-9629569	7.347347e-01	0.134
Creatine metabolism	R-HSA-71288	7.347347e-01	0.134
Signaling by NODAL	R-HSA-1181150	7.347347e-01	0.134
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	7.368984e-01	0.133
Hh mutants are degraded by ERAD	R-HSA-5362768	7.368984e-01	0.133
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	7.368984e-01	0.133
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.427288e-01	0.129
DNA replication initiation	R-HSA-68952	7.427288e-01	0.129
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	7.427288e-01	0.129
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.427288e-01	0.129
Interleukin-27 signaling	R-HSA-9020956	7.427288e-01	0.129
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.427288e-01	0.129
Receptor Mediated Mitophagy	R-HSA-8934903	7.427288e-01	0.129
Degradation of GLI1 by the proteasome	R-HSA-5610780	7.511969e-01	0.124
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.511969e-01	0.124
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.511969e-01	0.124
MAPK6/MAPK4 signaling	R-HSA-5687128	7.531178e-01	0.123
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.534944e-01	0.123
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	7.541453e-01	0.123
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.541453e-01	0.123
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.541453e-01	0.123
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.541453e-01	0.123
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.541453e-01	0.123
Zygotic genome activation (ZGA)	R-HSA-9819196	7.541453e-01	0.123
Inwardly rectifying K+ channels	R-HSA-1296065	7.573433e-01	0.121
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.573433e-01	0.121
Immune System	R-HSA-168256	7.608861e-01	0.119
Insulin receptor signalling cascade	R-HSA-74751	7.609346e-01	0.119
Generic Transcription Pathway	R-HSA-212436	7.611060e-01	0.119
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	7.632158e-01	0.117
Activation of GABAB receptors	R-HSA-991365	7.648906e-01	0.116
GABA B receptor activation	R-HSA-977444	7.648906e-01	0.116
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	7.648906e-01	0.116
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.650614e-01	0.116
Activation of HOX genes during differentiation	R-HSA-5619507	7.679811e-01	0.115
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	7.679811e-01	0.115
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.682515e-01	0.114
vRNA Synthesis	R-HSA-192814	7.682515e-01	0.114
Conjugation of benzoate with glycine	R-HSA-177135	7.682515e-01	0.114
vRNP Assembly	R-HSA-192905	7.682515e-01	0.114
Synthesis of PI	R-HSA-1483226	7.682515e-01	0.114
RHOBTB3 ATPase cycle	R-HSA-9706019	7.682515e-01	0.114
Activated NTRK3 signals through RAS	R-HSA-9034864	7.682515e-01	0.114
Bicarbonate transporters	R-HSA-425381	7.682515e-01	0.114
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	7.682515e-01	0.114
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.682515e-01	0.114
PECAM1 interactions	R-HSA-210990	7.682515e-01	0.114
Dissolution of Fibrin Clot	R-HSA-75205	7.682515e-01	0.114
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.723170e-01	0.112
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	7.723170e-01	0.112
Serine metabolism	R-HSA-977347	7.723170e-01	0.112
Assembly of the ORC complex at the origin of replication	R-HSA-68616	7.725037e-01	0.112
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	7.725037e-01	0.112
Hh mutants abrogate ligand secretion	R-HSA-5387390	7.779887e-01	0.109
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.836368e-01	0.106
Vpu mediated degradation of CD4	R-HSA-180534	7.868791e-01	0.104
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	7.868791e-01	0.104
Heme degradation	R-HSA-189483	7.868791e-01	0.104
Miscellaneous transport and binding events	R-HSA-5223345	7.868791e-01	0.104
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.893044e-01	0.103
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.893044e-01	0.103
Fructose metabolism	R-HSA-5652084	7.893044e-01	0.103
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	7.893044e-01	0.103
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.893044e-01	0.103
Proteasome assembly	R-HSA-9907900	7.905025e-01	0.102
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	7.905025e-01	0.102
Amine ligand-binding receptors	R-HSA-375280	7.905025e-01	0.102
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.912436e-01	0.102
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.912436e-01	0.102
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	7.912436e-01	0.102
Proton-coupled monocarboxylate transport	R-HSA-433692	7.912436e-01	0.102
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.912436e-01	0.102
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.912436e-01	0.102
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.912436e-01	0.102
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.912436e-01	0.102
Activated NTRK2 signals through RAS	R-HSA-9026519	7.912436e-01	0.102
Integrin cell surface interactions	R-HSA-216083	7.919008e-01	0.101
NOD1/2 Signaling Pathway	R-HSA-168638	8.004926e-01	0.097
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.004926e-01	0.097
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.004926e-01	0.097
Hyaluronan metabolism	R-HSA-2142845	8.004926e-01	0.097
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	8.004926e-01	0.097
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	8.004926e-01	0.097
Post-translational protein phosphorylation	R-HSA-8957275	8.008178e-01	0.096
Regulation of insulin secretion	R-HSA-422356	8.008178e-01	0.096
Defective CFTR causes cystic fibrosis	R-HSA-5678895	8.024444e-01	0.096
Asymmetric localization of PCP proteins	R-HSA-4608870	8.024444e-01	0.096
Regulated Necrosis	R-HSA-5218859	8.032640e-01	0.095
Regulation of PTEN mRNA translation	R-HSA-8943723	8.051638e-01	0.094
Carnitine shuttle	R-HSA-200425	8.051638e-01	0.094
Formation of the ureteric bud	R-HSA-9830674	8.051638e-01	0.094
PI3K/AKT Signaling in Cancer	R-HSA-2219528	8.103390e-01	0.091
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	8.119558e-01	0.090
Interleukin-15 signaling	R-HSA-8983432	8.119558e-01	0.090
Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77285	8.119558e-01	0.090
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	8.119558e-01	0.090
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	8.119558e-01	0.090
Interleukin-35 Signalling	R-HSA-8984722	8.119558e-01	0.090
Regulation of IFNG signaling	R-HSA-877312	8.119558e-01	0.090
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.119558e-01	0.090
Conjugation of salicylate with glycine	R-HSA-177128	8.119558e-01	0.090
MET activates RAS signaling	R-HSA-8851805	8.119558e-01	0.090
Signaling by LTK	R-HSA-9842663	8.119558e-01	0.090
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.119558e-01	0.090
Role of second messengers in netrin-1 signaling	R-HSA-418890	8.119558e-01	0.090
Synthesis of GDP-mannose	R-HSA-446205	8.119558e-01	0.090
OAS antiviral response	R-HSA-8983711	8.119558e-01	0.090
SHC-related events triggered by IGF1R	R-HSA-2428933	8.119558e-01	0.090
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	8.119558e-01	0.090
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	8.119558e-01	0.090
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.119558e-01	0.090
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.119558e-01	0.090
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.128834e-01	0.090
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.131351e-01	0.090
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.133689e-01	0.090
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.138281e-01	0.089
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.138281e-01	0.089
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.156941e-01	0.088
TCR signaling	R-HSA-202403	8.170231e-01	0.088
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.199515e-01	0.086
Interleukin-6 family signaling	R-HSA-6783589	8.199515e-01	0.086
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.199515e-01	0.086
Negative regulation of the PI3K/AKT network	R-HSA-199418	8.253344e-01	0.083
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.255336e-01	0.083
Gastrulation	R-HSA-9758941	8.275782e-01	0.082
Toll-like Receptor Cascades	R-HSA-168898	8.286222e-01	0.082
tRNA processing	R-HSA-72306	8.305953e-01	0.081
Adenylate cyclase activating pathway	R-HSA-170660	8.306141e-01	0.081
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.306141e-01	0.081
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	8.306141e-01	0.081
Processing of SMDT1	R-HSA-8949664	8.306141e-01	0.081
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.306141e-01	0.081
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.306141e-01	0.081
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.306141e-01	0.081
CD28 dependent Vav1 pathway	R-HSA-389359	8.306141e-01	0.081
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.306141e-01	0.081
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.337242e-01	0.079
Hyaluronan degradation	R-HSA-2160916	8.337242e-01	0.079
NCAM1 interactions	R-HSA-419037	8.370133e-01	0.077
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.370133e-01	0.077
Degradation of AXIN	R-HSA-4641257	8.370133e-01	0.077
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.370133e-01	0.077
Ovarian tumor domain proteases	R-HSA-5689896	8.370133e-01	0.077
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	8.395305e-01	0.076
Maternal to zygotic transition (MZT)	R-HSA-9816359	8.445654e-01	0.073
Aquaporin-mediated transport	R-HSA-445717	8.453040e-01	0.073
Formation of paraxial mesoderm	R-HSA-9793380	8.453040e-01	0.073
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	8.465375e-01	0.072
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.465375e-01	0.072
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.465375e-01	0.072
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.465375e-01	0.072
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.465375e-01	0.072
NRIF signals cell death from the nucleus	R-HSA-205043	8.474221e-01	0.072
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	8.474221e-01	0.072
CRMPs in Sema3A signaling	R-HSA-399956	8.474221e-01	0.072
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.474221e-01	0.072
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	8.474221e-01	0.072
Hydrolysis of LPC	R-HSA-1483115	8.474221e-01	0.072
Formation of the active cofactor, UDP-glucuronate	R-HSA-173599	8.474221e-01	0.072
Malate-aspartate shuttle	R-HSA-9856872	8.474221e-01	0.072
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.474221e-01	0.072
Signaling by FGFR4 in disease	R-HSA-5655291	8.474221e-01	0.072
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.474221e-01	0.072
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.478350e-01	0.072
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.478350e-01	0.072
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.525004e-01	0.069
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	8.564744e-01	0.067
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	8.580260e-01	0.066
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.580260e-01	0.066
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	8.584463e-01	0.066
Packaging Of Telomere Ends	R-HSA-171306	8.584463e-01	0.066
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	8.584463e-01	0.066
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	8.625631e-01	0.064
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.625631e-01	0.064
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.625631e-01	0.064
Protein lipoylation	R-HSA-9857492	8.625631e-01	0.064
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	8.625631e-01	0.064
Protein repair	R-HSA-5676934	8.625631e-01	0.064
Beta oxidation of butanoyl-CoA to acetyl-CoA	R-HSA-77352	8.625631e-01	0.064
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	8.625631e-01	0.064
Lysosphingolipid and LPA receptors	R-HSA-419408	8.625631e-01	0.064
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.625631e-01	0.064
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.625631e-01	0.064
DNA Damage Reversal	R-HSA-73942	8.625631e-01	0.064
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.629107e-01	0.064
Activation of NF-kappaB in B cells	R-HSA-1169091	8.629107e-01	0.064
Hedgehog ligand biogenesis	R-HSA-5358346	8.629107e-01	0.064
Inhibition of DNA recombination at telomere	R-HSA-9670095	8.676138e-01	0.062
HIV Transcription Elongation	R-HSA-167169	8.676138e-01	0.062
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	8.676138e-01	0.062
Interleukin-2 family signaling	R-HSA-451927	8.676138e-01	0.062
Glycogen metabolism	R-HSA-8982491	8.676138e-01	0.062
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	8.695038e-01	0.061
Formation of the Early Elongation Complex	R-HSA-113418	8.695038e-01	0.061
Telomere Extension By Telomerase	R-HSA-171319	8.695038e-01	0.061
Prednisone ADME	R-HSA-9757110	8.695038e-01	0.061
HCMV Late Events	R-HSA-9610379	8.719211e-01	0.060
Pyruvate metabolism	R-HSA-70268	8.719583e-01	0.060
Telomere Maintenance	R-HSA-157579	8.744856e-01	0.058
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.762024e-01	0.057
Defective GALNT3 causes HFTC	R-HSA-5083625	8.762024e-01	0.057
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.762024e-01	0.057
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.762024e-01	0.057
Killing mechanisms	R-HSA-9664420	8.762024e-01	0.057
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.762024e-01	0.057
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.762024e-01	0.057
Attachment and Entry	R-HSA-9678110	8.762024e-01	0.057
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	8.762024e-01	0.057
Virus Assembly and Release	R-HSA-168268	8.762024e-01	0.057
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.766257e-01	0.057
Stimuli-sensing channels	R-HSA-2672351	8.774785e-01	0.057
DNA methylation	R-HSA-5334118	8.797616e-01	0.056
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.797616e-01	0.056
mRNA Capping	R-HSA-72086	8.797616e-01	0.056
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.797616e-01	0.056
Intra-Golgi traffic	R-HSA-6811438	8.850887e-01	0.053
Degradation of CRY and PER proteins	R-HSA-9932298	8.850887e-01	0.053
Signaling by FGFR1 in disease	R-HSA-5655302	8.850887e-01	0.053
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.850887e-01	0.053
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.867604e-01	0.052
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	8.884889e-01	0.051
Glycine degradation	R-HSA-6783984	8.884889e-01	0.051
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.884889e-01	0.051
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	R-HSA-77288	8.884889e-01	0.051
SHC1 events in ERBB4 signaling	R-HSA-1250347	8.884889e-01	0.051
Galactose catabolism	R-HSA-70370	8.884889e-01	0.051
Biosynthesis of maresin-like SPMs	R-HSA-9027307	8.884889e-01	0.051
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.892696e-01	0.051
Base Excision Repair	R-HSA-73884	8.903217e-01	0.050
Paracetamol ADME	R-HSA-9753281	8.937762e-01	0.049
Transcription of the HIV genome	R-HSA-167172	8.970568e-01	0.047
Molecules associated with elastic fibres	R-HSA-2129379	8.980755e-01	0.047
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.980755e-01	0.047
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.980755e-01	0.047
Cardiac conduction	R-HSA-5576891	8.984384e-01	0.047
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.995566e-01	0.046
Glycogen storage diseases	R-HSA-3229121	8.995566e-01	0.046
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.995566e-01	0.046
Regulation of FZD by ubiquitination	R-HSA-4641263	8.995566e-01	0.046
Sulfide oxidation to sulfate	R-HSA-1614517	8.995566e-01	0.046
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	8.995566e-01	0.046
Choline catabolism	R-HSA-6798163	8.995566e-01	0.046
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.995566e-01	0.046
PI Metabolism	R-HSA-1483255	9.020044e-01	0.045
Protein localization	R-HSA-9609507	9.039072e-01	0.044
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.050825e-01	0.043
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.062249e-01	0.043
DAP12 interactions	R-HSA-2172127	9.074478e-01	0.042
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.087733e-01	0.042
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.095264e-01	0.041
RNA Polymerase III Transcription Termination	R-HSA-73980	9.095264e-01	0.041
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.095264e-01	0.041
PPARA activates gene expression	R-HSA-1989781	9.116758e-01	0.040
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.123098e-01	0.040
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	9.137613e-01	0.039
FGFR1 mutant receptor activation	R-HSA-1839124	9.137613e-01	0.039
Cardiogenesis	R-HSA-9733709	9.137613e-01	0.039
Recycling of bile acids and salts	R-HSA-159418	9.137613e-01	0.039
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.137613e-01	0.039
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.139757e-01	0.039
Somitogenesis	R-HSA-9824272	9.139757e-01	0.039
RSV-host interactions	R-HSA-9833110	9.159310e-01	0.038
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.183646e-01	0.037
IKK complex recruitment mediated by RIP1	R-HSA-937041	9.185072e-01	0.037
Impaired BRCA2 binding to PALB2	R-HSA-9709603	9.185072e-01	0.037
Signaling by FGFR2 IIIa TM	R-HSA-8851708	9.185072e-01	0.037
HDL remodeling	R-HSA-8964058	9.185072e-01	0.037
Conjugation of carboxylic acids	R-HSA-159424	9.185072e-01	0.037
Amino Acid conjugation	R-HSA-156587	9.185072e-01	0.037
Pyrimidine biosynthesis	R-HSA-500753	9.185072e-01	0.037
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.185072e-01	0.037
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.189142e-01	0.037
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.200818e-01	0.036
Regulation of pyruvate metabolism	R-HSA-9861718	9.200818e-01	0.036
Diseases of DNA repair	R-HSA-9675135	9.200818e-01	0.036
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.207262e-01	0.036
Acyl chain remodelling of PC	R-HSA-1482788	9.207262e-01	0.036
GABA receptor activation	R-HSA-977443	9.236561e-01	0.034
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.236561e-01	0.034
Aspirin ADME	R-HSA-9749641	9.241571e-01	0.034
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	9.265970e-01	0.033
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	9.265970e-01	0.033
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	9.265970e-01	0.033
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	9.265970e-01	0.033
Acyl chain remodelling of PI	R-HSA-1482922	9.265970e-01	0.033
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.265970e-01	0.033
Pregnenolone biosynthesis	R-HSA-196108	9.265970e-01	0.033
eNOS activation	R-HSA-203615	9.271588e-01	0.033
Mitophagy	R-HSA-5205647	9.271588e-01	0.033
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.271588e-01	0.033
Parasitic Infection Pathways	R-HSA-9824443	9.281475e-01	0.032
Leishmania infection	R-HSA-9658195	9.281475e-01	0.032
IRS-related events triggered by IGF1R	R-HSA-2428928	9.286371e-01	0.032
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.286371e-01	0.032
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.287521e-01	0.032
Antigen processing-Cross presentation	R-HSA-1236975	9.318339e-01	0.031
Iron uptake and transport	R-HSA-917937	9.330901e-01	0.030
Transferrin endocytosis and recycling	R-HSA-917977	9.330959e-01	0.030
Acyl chain remodelling of PE	R-HSA-1482839	9.330959e-01	0.030
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	9.330959e-01	0.030
Mitochondrial protein import	R-HSA-1268020	9.333229e-01	0.030
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.333229e-01	0.030
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.338841e-01	0.030
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.338841e-01	0.030
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.338841e-01	0.030
Acyl chain remodelling of PG	R-HSA-1482925	9.338841e-01	0.030
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.338841e-01	0.030
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.358592e-01	0.029
Leishmania phagocytosis	R-HSA-9664417	9.358592e-01	0.029
Parasite infection	R-HSA-9664407	9.358592e-01	0.029
UCH proteinases	R-HSA-5689603	9.371937e-01	0.028
GPVI-mediated activation cascade	R-HSA-114604	9.385726e-01	0.028
Triglyceride catabolism	R-HSA-163560	9.385726e-01	0.028
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.404482e-01	0.027
Mitochondrial calcium ion transport	R-HSA-8949215	9.404482e-01	0.027
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.404482e-01	0.027
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.404482e-01	0.027
Molybdenum cofactor biosynthesis	R-HSA-947581	9.404482e-01	0.027
Glutathione synthesis and recycling	R-HSA-174403	9.404482e-01	0.027
Attachment and Entry	R-HSA-9694614	9.404482e-01	0.027
ER-Phagosome pathway	R-HSA-1236974	9.416755e-01	0.026
IGF1R signaling cascade	R-HSA-2428924	9.418671e-01	0.026
TRAF6 mediated IRF7 activation	R-HSA-933541	9.436218e-01	0.025
Cleavage of the damaged purine	R-HSA-110331	9.436218e-01	0.025
ABC transporter disorders	R-HSA-5619084	9.447293e-01	0.025
Cholesterol biosynthesis	R-HSA-191273	9.447293e-01	0.025
Meiotic recombination	R-HSA-912446	9.450679e-01	0.025
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.457536e-01	0.024
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.463609e-01	0.024
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.463609e-01	0.024
Ethanol oxidation	R-HSA-71384	9.463609e-01	0.024
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.463609e-01	0.024
Signaling by KIT in disease	R-HSA-9669938	9.463609e-01	0.024
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.463609e-01	0.024
SLC transporter disorders	R-HSA-5619102	9.480384e-01	0.023
Elastic fibre formation	R-HSA-1566948	9.482743e-01	0.023
tRNA processing in the mitochondrion	R-HSA-6785470	9.482743e-01	0.023
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.482743e-01	0.023
Depurination	R-HSA-73927	9.482743e-01	0.023
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.482743e-01	0.023
Uptake and actions of bacterial toxins	R-HSA-5339562	9.491008e-01	0.023
Interleukin receptor SHC signaling	R-HSA-912526	9.516869e-01	0.022
Termination of O-glycan biosynthesis	R-HSA-977068	9.516869e-01	0.022
Interleukin-20 family signaling	R-HSA-8854691	9.516869e-01	0.022
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.516869e-01	0.022
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.516869e-01	0.022
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.516869e-01	0.022
Organic anion transport by SLCO transporters	R-HSA-879518	9.516869e-01	0.022
ABC transporters in lipid homeostasis	R-HSA-1369062	9.516869e-01	0.022
Biosynthesis of maresins	R-HSA-9018682	9.516869e-01	0.022
Kidney development	R-HSA-9830369	9.528218e-01	0.021
Amino acids regulate mTORC1	R-HSA-9639288	9.528563e-01	0.021
Nucleotide biosynthesis	R-HSA-8956320	9.528563e-01	0.021
Signaling by Insulin receptor	R-HSA-74752	9.542694e-01	0.020
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.542694e-01	0.020
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	9.550199e-01	0.020
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	9.550199e-01	0.020
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	9.550199e-01	0.020
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.564844e-01	0.019
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.564844e-01	0.019
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.564844e-01	0.019
Complex III assembly	R-HSA-9865881	9.564844e-01	0.019
Mitochondrial RNA degradation	R-HSA-9836573	9.564844e-01	0.019
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.564844e-01	0.019
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.565033e-01	0.019
Diseases of Immune System	R-HSA-5260271	9.565033e-01	0.019
rRNA processing in the mitochondrion	R-HSA-8868766	9.565033e-01	0.019
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.565033e-01	0.019
Interferon alpha/beta signaling	R-HSA-909733	9.583480e-01	0.018
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.601323e-01	0.018
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.601323e-01	0.018
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	9.608057e-01	0.017
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.608057e-01	0.017
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.608057e-01	0.017
Laminin interactions	R-HSA-3000157	9.608057e-01	0.017
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.608057e-01	0.017
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.618468e-01	0.017
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.620413e-01	0.017
Scavenging by Class A Receptors	R-HSA-3000480	9.634698e-01	0.016
Translation of Structural Proteins	R-HSA-9683701	9.634698e-01	0.016
Metabolism of porphyrins	R-HSA-189445	9.644802e-01	0.016
MET activates PTK2 signaling	R-HSA-8874081	9.646981e-01	0.016
Urea cycle	R-HSA-70635	9.646981e-01	0.016
Sphingolipid catabolism	R-HSA-9845614	9.646981e-01	0.016
Abacavir ADME	R-HSA-2161522	9.646981e-01	0.016
Suppression of phagosomal maturation	R-HSA-9637687	9.646981e-01	0.016
IRS-mediated signalling	R-HSA-112399	9.654348e-01	0.015
Cleavage of the damaged pyrimidine	R-HSA-110329	9.665379e-01	0.015
Depyrimidination	R-HSA-73928	9.665379e-01	0.015
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.680439e-01	0.014
Signaling by BMP	R-HSA-201451	9.682042e-01	0.014
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.682042e-01	0.014
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	9.682042e-01	0.014
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.682042e-01	0.014
Triglyceride biosynthesis	R-HSA-75109	9.682042e-01	0.014
Synthesis of PE	R-HSA-1483213	9.682042e-01	0.014
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.682042e-01	0.014
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.682042e-01	0.014
Signaling by FGFR3 in disease	R-HSA-5655332	9.682042e-01	0.014
Peroxisomal protein import	R-HSA-9033241	9.704660e-01	0.013
Triglyceride metabolism	R-HSA-8979227	9.704660e-01	0.013
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.713622e-01	0.013
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.713622e-01	0.013
Pyrimidine salvage	R-HSA-73614	9.713622e-01	0.013
Pyroptosis	R-HSA-5620971	9.713622e-01	0.013
Signaling by FGFR in disease	R-HSA-1226099	9.714001e-01	0.013
Metabolism of polyamines	R-HSA-351202	9.727137e-01	0.012
Extracellular matrix organization	R-HSA-1474244	9.737450e-01	0.012
Downstream signaling of activated FGFR3	R-HSA-5654708	9.742068e-01	0.011
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	9.743242e-01	0.011
Degradation of cysteine and homocysteine	R-HSA-1614558	9.743242e-01	0.011
Formation of the cornified envelope	R-HSA-6809371	9.752116e-01	0.011
G alpha (q) signalling events	R-HSA-416476	9.757075e-01	0.011
Interleukin-1 signaling	R-HSA-9020702	9.757123e-01	0.011
Condensation of Prophase Chromosomes	R-HSA-2299718	9.765065e-01	0.010
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.765065e-01	0.010
Downstream signaling of activated FGFR4	R-HSA-5654716	9.767689e-01	0.010
Neurotransmitter clearance	R-HSA-112311	9.767689e-01	0.010
Neurotransmitter release cycle	R-HSA-112310	9.767790e-01	0.010
Class B/2 (Secretin family receptors)	R-HSA-373080	9.767790e-01	0.010
Downstream TCR signaling	R-HSA-202424	9.767790e-01	0.010
Translation of Structural Proteins	R-HSA-9694635	9.770421e-01	0.010
C-type lectin receptors (CLRs)	R-HSA-5621481	9.773845e-01	0.010
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.785088e-01	0.009
Synthesis of PC	R-HSA-1483191	9.785088e-01	0.009
Cargo concentration in the ER	R-HSA-5694530	9.790767e-01	0.009
Aspartate and asparagine metabolism	R-HSA-8963693	9.790767e-01	0.009
Plasma lipoprotein remodeling	R-HSA-8963899	9.803452e-01	0.009
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.811554e-01	0.008
Disorders of transmembrane transporters	R-HSA-5619115	9.818023e-01	0.008
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.820290e-01	0.008
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.820290e-01	0.008
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.824186e-01	0.008
Interleukin-1 family signaling	R-HSA-446652	9.828027e-01	0.008
PI3K Cascade	R-HSA-109704	9.835724e-01	0.007
Signaling by FGFR2 in disease	R-HSA-5655253	9.835724e-01	0.007
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.836123e-01	0.007
Mitochondrial protein degradation	R-HSA-9837999	9.836123e-01	0.007
Glutamate and glutamine metabolism	R-HSA-8964539	9.847139e-01	0.007
Branched-chain amino acid catabolism	R-HSA-70895	9.849866e-01	0.007
Complex IV assembly	R-HSA-9864848	9.849866e-01	0.007
The phototransduction cascade	R-HSA-2514856	9.849866e-01	0.007
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	9.862328e-01	0.006
Calnexin/calreticulin cycle	R-HSA-901042	9.862328e-01	0.006
RA biosynthesis pathway	R-HSA-5365859	9.862328e-01	0.006
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.862328e-01	0.006
Degradation of the extracellular matrix	R-HSA-1474228	9.864554e-01	0.006
Downstream signaling of activated FGFR2	R-HSA-5654696	9.876009e-01	0.005
Downstream signaling of activated FGFR1	R-HSA-5654687	9.876009e-01	0.005
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.876009e-01	0.005
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.877995e-01	0.005
COPII-mediated vesicle transport	R-HSA-204005	9.878394e-01	0.005
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.885546e-01	0.005
ECM proteoglycans	R-HSA-3000178	9.888006e-01	0.005
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.888330e-01	0.005
FGFR2 mutant receptor activation	R-HSA-1839126	9.888330e-01	0.005
FCERI mediated MAPK activation	R-HSA-2871796	9.890911e-01	0.005
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.899428e-01	0.004
Collagen chain trimerization	R-HSA-8948216	9.899428e-01	0.004
Metabolism of folate and pterines	R-HSA-196757	9.899428e-01	0.004
Diseases of carbohydrate metabolism	R-HSA-5663084	9.905081e-01	0.004
Purine salvage	R-HSA-74217	9.909424e-01	0.004
Dectin-2 family	R-HSA-5621480	9.912905e-01	0.004
Synthesis of PA	R-HSA-1483166	9.912905e-01	0.004
RAS processing	R-HSA-9648002	9.918426e-01	0.004
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.918426e-01	0.004
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.926535e-01	0.003
Amino acid transport across the plasma membrane	R-HSA-352230	9.927474e-01	0.003
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.928695e-01	0.003
Aflatoxin activation and detoxification	R-HSA-5423646	9.933837e-01	0.003
Maturation of spike protein	R-HSA-9694548	9.933837e-01	0.003
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.937131e-01	0.003
SLC-mediated transport of organic anions	R-HSA-9955298	9.937492e-01	0.003
Collagen degradation	R-HSA-1442490	9.939649e-01	0.003
HIV Transcription Initiation	R-HSA-167161	9.940415e-01	0.003
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.940415e-01	0.003
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.940415e-01	0.003
Heme biosynthesis	R-HSA-189451	9.940415e-01	0.003
Neddylation	R-HSA-8951664	9.943154e-01	0.002
Collagen formation	R-HSA-1474290	9.946280e-01	0.002
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.946338e-01	0.002
Amyloid fiber formation	R-HSA-977225	9.951479e-01	0.002
RNA Polymerase II Promoter Escape	R-HSA-73776	9.951674e-01	0.002
Defensins	R-HSA-1461973	9.951674e-01	0.002
Pyrimidine catabolism	R-HSA-73621	9.951674e-01	0.002
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.953132e-01	0.002
Leishmania parasite growth and survival	R-HSA-9664433	9.953132e-01	0.002
Infectious disease	R-HSA-5663205	9.954958e-01	0.002
G1 Phase	R-HSA-69236	9.956479e-01	0.002
Cyclin D associated events in G1	R-HSA-69231	9.956479e-01	0.002
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.959061e-01	0.002
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.960806e-01	0.002
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.961988e-01	0.002
Nicotinate metabolism	R-HSA-196807	9.965361e-01	0.002
SLC-mediated transport of amino acids	R-HSA-9958863	9.965361e-01	0.002
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.967204e-01	0.001
Drug ADME	R-HSA-9748784	9.967521e-01	0.001
O-linked glycosylation of mucins	R-HSA-913709	9.968439e-01	0.001
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.970924e-01	0.001
Metabolism of steroids	R-HSA-8957322	9.974072e-01	0.001
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.976148e-01	0.001
Metabolism of cofactors	R-HSA-8978934	9.976148e-01	0.001
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.976786e-01	0.001
Innate Immune System	R-HSA-168249	9.978588e-01	0.001
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.981174e-01	0.001
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.981996e-01	0.001
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.983121e-01	0.001
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.983664e-01	0.001
Glucuronidation	R-HSA-156588	9.984734e-01	0.001
Bile acid and bile salt metabolism	R-HSA-194068	9.987442e-01	0.001
Potassium Channels	R-HSA-1296071	9.989759e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.989789e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.991342e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.991732e-01	0.000
RAB geranylgeranylation	R-HSA-8873719	9.991860e-01	0.000
Glutathione conjugation	R-HSA-156590	9.991860e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.991860e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.992138e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.992392e-01	0.000
Endogenous sterols	R-HSA-211976	9.992670e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.992670e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.993004e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.994057e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.994061e-01	0.000
Xenobiotics	R-HSA-211981	9.994649e-01	0.000
Glycosphingolipid biosynthesis	R-HSA-9840309	9.994649e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.994743e-01	0.000
Post-translational protein modification	R-HSA-597592	9.994975e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.995328e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.996093e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.996093e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.996360e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.996482e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.997148e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.997536e-01	0.000
Purine catabolism	R-HSA-74259	9.997688e-01	0.000
Transport of small molecules	R-HSA-382551	9.997824e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.997984e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.998125e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.998568e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.998568e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.998768e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.998891e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.998891e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999026e-01	0.000
Metabolism of proteins	R-HSA-392499	9.999041e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999101e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999207e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999410e-01	0.000
Keratinization	R-HSA-6805567	9.999414e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.999587e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999737e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999739e-01	0.000
FCGR activation	R-HSA-2029481	9.999793e-01	0.000
Disease	R-HSA-1643685	9.999847e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999864e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999864e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999890e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999902e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999911e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999922e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999935e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999947e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999955e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999961e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999967e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999969e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999973e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999974e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999983e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999990e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999992e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999994e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999994e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999995e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999997e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999998e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999998e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999999e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.999999e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999999e-01	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000