RSK4
Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Log-Odds: S Sites / S Background
Sites with acceptor types representing >8% and count ≥10 are included
Motif clusters with count ≥ 10 are shown
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| substrate_uniprot | site | source | substrate_genes | site_seq |
|---|---|---|---|---|
| A5A3E0 | S1068 | Sugiyama | POTEF A26C1B | SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________ |
| O14617 | S658 | Sugiyama | AP3D1 PRO0039 | DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN |
| O14618 | S267 | Sugiyama | CCS | DGLTIWEERGRPIAGKGRKEsAQPPAHL_____________ |
| O14974 | S692 | Sugiyama | PPP1R12A MBS MYPT1 | PVRDEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIG |
| O14974 | S695 | Sugiyama | PPP1R12A MBS MYPT1 | DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR |
| O14974 | S910 | Sugiyama | PPP1R12A MBS MYPT1 | yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST |
| O14980 | S1055 | Sugiyama | XPO1 CRM1 | LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____ |
| O15067 | S215 | Sugiyama | PFAS KIAA0361 | LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF |
| O15357 | S1176 | Sugiyama | INPPL1 SHIP2 | RGLPsDyGRPLsFPPPRIREsIQEDLAEEAPCLQGGRASGL |
| O43175 | S12 | Sugiyama | PHGDH PGDH3 | _________MAFANLRKVLIsDsLDPCCRKILQDGGLQVVE |
| O43707 | S423 | Sugiyama | ACTN4 | NEIRRLERLDHLAEKFRQKAsIHEAWtDGKEAMLKHRDyEt |
| O43823 | S323 | Sugiyama | AKAP8 AKAP95 | RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE |
| O43847 | S94 | Sugiyama | NRDC NRD1 | ENSRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYR |
| O43852 | S261 | Sugiyama | CALU | RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK |
| O60220 | S94 | Sugiyama | TIMM8A DDP DDP1 TIM8A | SQFILNRLEQTQKSKPVFSEsLsD_________________ |
| O60293 | S42 | Sugiyama | ZFC3H1 CCDC131 KIAA0546 PSRC2 | LEDGEIsDDDNNSQIRSRsssSsSGGGLLPYPRRRPPHSAR |
| O60343 | S751 | Sugiyama | TBC1D4 AS160 KIAA0603 | EIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRIS |
| O60739 | T45 | Sugiyama | EIF1B | AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK |
| O60814 | S37 | Sugiyama | H2BC12 H2BFT HIRIP1 HIST1H2BK | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| O60814 | S39 | Sugiyama | H2BC12 H2BFT HIRIP1 HIST1H2BK | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| O60841 | S182 | Sugiyama | EIF5B IF2 KIAA0741 | DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK |
| O75122 | S523 | Sugiyama | CLASP2 KIAA0627 | sREAsPSRLSVARSSRIPRPsVsQGCsREAsRESsRDTsPV |
| O75152 | S758 | Sugiyama | ZC3H11A KIAA0663 ZC3HDC11A | sPPEVsGPSSSQMSMKTRRLssAstGKPPLsVEDDFEKLIW |
| O75152 | S759 | Sugiyama | ZC3H11A KIAA0663 ZC3HDC11A | PPEVsGPSSSQMSMKTRRLssAstGKPPLsVEDDFEKLIWE |
| O75347 | S103 | Sugiyama | TBCA | ENEKDLEEAEEyKEARLVLDsVKLEA_______________ |
| O75348 | S68 | Sugiyama | ATP6V1G1 ATP6G ATP6G1 ATP6J | RLQREKEFKAKEAAALGsRGsCstEVEKETQEKMTILQtyF |
| O95239 | S801 | Sugiyama | KIF4A KIF4 | LKEKKESGENPPPKLRRRtFsLtEVRGQVsEsEDsItKQIE |
| O95831 | S116 | Sugiyama | AIFM1 AIF PDCD8 | NERIsGLGLtPEQKQKKAALsAsEGEEVPQDKAPSHVPFLL |
| P00338 | S161 | Sugiyama | LDHA PIG19 | DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH |
| P00338 | S319 | Sugiyama | LDHA PIG19 | GISDLVKVTLtsEEEARLKKsADtLWGIQKELQF_______ |
| P00491 | S176 | Sugiyama | PNP NP | GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA |
| P00558 | S390 | Sugiyama | PGK1 PGKA MIG10 OK/SW-cl.110 | IIGGGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPG |
| P00558 | S399 | Sugiyama | PGK1 PGKA MIG10 OK/SW-cl.110 | CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__ |
| P04075 | S36 | Sugiyama | ALDOA ALDA | LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR |
| P04075 | S39 | Sugiyama | ALDOA ALDA | IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy |
| P04075 | S46 | Sugiyama | ALDOA ALDA | PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA |
| P04075 | T65 | Sugiyama | ALDOA ALDA | QsIGtENtEENRRFyRQLLLtADDRVNPCIGGVILFHETLY |
| P04083 | S182 | Sugiyama | ANXA1 ANX1 LPC1 | RDLAKDItsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsD |
| P04406 | S241 | Sugiyama | GAPDH GAPD CDABP0047 OK/SW-cl.12 | IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV |
| P04792 | S78 | Sugiyama | HSPB1 HSP27 HSP28 | LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs |
| P04792 | S82 | Sugiyama | HSPB1 HSP27 HSP28 | AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN |
| P04792 | S83 | Sugiyama | HSPB1 HSP27 HSP28 | IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH |
| P04792 | S86 | Sugiyama | HSPB1 HSP27 HSP28 | PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP |
| P05386 | S101 | Sugiyama | RPLP1 RRP1 | APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______ |
| P05387 | S102 | Sugiyama | RPLP2 D11S2243E RPP2 | PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______ |
| P05387 | S29 | Sugiyama | RPLP2 D11S2243E RPP2 | LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK |
| P05787 | S330 | Sugiyama | KRT8 CYK8 | MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN |
| P05787 | S475 | Sugiyama | KRT8 CYK8 | TSSSRAVVVKKIETRDGKLVsEssDVLPK____________ |
| P06493 | S39 | Sugiyama | CDK1 CDC2 CDC28A CDKN1 P34CDC2 | yKGRHKTTGQVVAMKKIRLEsEEEGVPstAIREIsLLKELR |
| P06733 | S291 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | IsPDQLADLyKsFIKDyPVVsIEDPFDQDDWGAWQKFtAsA |
| P06733 | S37 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY |
| P06899 | S37 | Sugiyama | H2BC11 H2BFR HIST1H2BJ | KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS |
| P06899 | S39 | Sugiyama | H2BC11 H2BFR HIST1H2BJ | VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA |
| P07195 | S162 | Sugiyama | LDHB | DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH |
| P07195 | S303 | Sugiyama | LDHB | GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt |
| P07205 | S390 | Sugiyama | PGK2 PGKB | VIGGGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPG |
| P07205 | S399 | Sugiyama | PGK2 PGKB | CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__ |
| P07237 | S427 | Sugiyama | P4HB ERBA2L PDI PDIA1 PO4DB | WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP |
| P07355 | S184 | Sugiyama | ANXA2 ANX2 ANX2L4 CAL1H LPC2D | sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK |
| P07711 | S326 | Sugiyama | CTSL CTSL1 | WGMGGyVKMAKDRRNHCGIAsAAsyPtV_____________ |
| P07737 | S30 | Sugiyama | PFN1 | NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV |
| P07814 | S1336 | Sugiyama | EPRS1 EPRS GLNS PARS QARS QPRS PIG32 | SEEDKEALIAKCNDYRRRLLsVNIRVRADLRDNysPGWKFN |
| P07814 | S739 | Sugiyama | EPRS1 EPRS GLNS PARS QARS QPRS PIG32 | TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV |
| P07864 | S161 | Sugiyama | LDHC LDH3 LDHX | DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH |
| P07900 | S391 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV |
| P07900 | S50 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL |
| P07900 | S63 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN |
| P08238 | S383 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV |
| P08238 | S45 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL |
| P08238 | S452 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy |
| P08238 | S460 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ |
| P08238 | S462 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs |
| P08238 | S468 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG |
| P08238 | S58 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN |
| P08238 | T467 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt |
| P08238 | Y457 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK |
| P08670 | S325 | Sugiyama | VIM | NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR |
| P09104 | S37 | Sugiyama | ENO2 | NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY |
| P0CG38 | S1068 | Sugiyama | POTEI | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P0CG39 | S1031 | Sugiyama | POTEJ | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P0CG47 | S57 | Sugiyama | UBB | PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM |
| P0CG48 | S57 | Sugiyama | UBC | PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM |
| P11142 | S40 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA |
| P11274 | S239 | Sugiyama | BCR BCR1 D22S11 | AGssVGDASRPPYRGRssEssCGVDGDyEDAELNPRFLKDN |
| P12814 | S404 | Sugiyama | ACTN1 | NEIRRLERLDHLAEKFRQKAsIHEAWtDGKEAMLRQKDyEt |
| P13639 | S23 | Sugiyama | EEF2 EF2 | NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA |
| P13639 | S578 | Sugiyama | EEF2 EF2 | LKDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNK |
| P13639 | T582 | Sugiyama | EEF2 EF2 | EEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRL |
| P13798 | S8 | Sugiyama | APEH D3F15S2 D3S48E DNF15S2 | _____________MERQVLLsEPEEAAALyRGLSRQPALsA |
| P13861 | S99 | Sugiyama | PRKAR2A PKR2 PRKAR2 | EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI |
| P13929 | S37 | Sugiyama | ENO3 | NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY |
| P14314 | S126 | Sugiyama | PRKCSH G19P1 | yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE |
| P14618 | S202 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs |
| P14618 | S97 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | sHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGP |
| P14618 | T95 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | NFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTK |
| P14625 | S106 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL |
| P14649 | S87 | Sugiyama | MYL6B MLC1SA | EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK |
| P15311 | S535 | Sugiyama | EZR VIL2 | EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN |
| P15336 | S62 | Sugiyama | ATF2 CREB2 CREBP1 | LAVHKHKHEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEV |
| P15531 | S120 | Sugiyama | NME1 NDPKA NM23 | KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV |
| P16333 | S85 | Sugiyama | NCK1 NCK | ASIVKNLKDTLGIGKVKRKPsVPDsAsPADDsFVDPGERLy |
| P17066 | S42 | Sugiyama | HSPA6 HSP70B' | VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA |
| P17544 | S44 | Sugiyama | ATF7 ATFA | LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV |
| P17812 | S573 | Sugiyama | CTPS1 CTPS | HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__ |
| P18615 | S113 | Sugiyama | NELFE RD RDBP | EGKLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLy |
| P18615 | S131 | Sugiyama | NELFE RD RDBP | QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE |
| P18621 | S5 | Sugiyama | RPL17 | ________________MVRysLDPENPtKsCKSRGSNLRVH |
| P19338 | S458 | Sugiyama | NCL | TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN |
| P19338 | S460 | Sugiyama | NCL | ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST |
| P19338 | Y462 | Sugiyama | NCL | AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs |
| P20042 | S67 | Sugiyama | EIF2S2 EIF2B | EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK |
| P20290 | S173 | Sugiyama | BTF3 NACB OK/SW-cl.8 | QLGADsLtsLRRLAEALPKQsVDGKAPLAtGEDDDDEVPDL |
| P20810 | S366 | Sugiyama | CAST | DKDGKPLLPEPEEKPKPRsEsELIDELsEDFDRsECKEKPS |
| P22087 | S124 | Sugiyama | FBL FIB1 FLRN | DALVTKNLVPGEsVyGEKRVsIsEGDDKIEyRAWNPFRSKL |
| P22090 | S204 | Sugiyama | RPS4Y1 RPS4Y PRO2646 | IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN |
| P23381 | S351 | Sugiyama | WARS1 IFI53 WARS WRS | KPALLHSTFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTK |
| P23381 | S353 | Sugiyama | WARS1 IFI53 WARS WRS | ALLHSTFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTKVN |
| P23381 | S467 | Sugiyama | WARS1 IFI53 WARS WRS | ARRKEVTDEIVKEFMTPRKLsFDFQ________________ |
| P23527 | S37 | Sugiyama | H2BC17 H2BFH H2BFN HIST1H2BO | KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS |
| P23527 | S39 | Sugiyama | H2BC17 H2BFH H2BFN HIST1H2BO | VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA |
| P23588 | S207 | Sugiyama | EIF4B | DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR |
| P23588 | S597 | Sugiyama | EIF4B | KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______ |
| P23588 | T205 | Sugiyama | EIF4B | GRDRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYR |
| P24534 | S141 | Sugiyama | EEF1B2 EEF1B EF1B | ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC |
| P25054 | S1389 | Sugiyama | APC DP2.5 | PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP |
| P25788 | S243 | Sugiyama | PSMA3 HC8 PSC8 | GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________ |
| P25789 | S7 | Sugiyama | PSMA4 HC9 PSC9 | ______________MSRRyDsRttIFsPEGRLYQVEYAMEA |
| P25789 | T10 | Sugiyama | PSMA4 HC9 PSC9 | ___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH |
| P25789 | Y5 | Sugiyama | PSMA4 HC9 PSC9 | ________________MSRRyDsRttIFsPEGRLYQVEYAM |
| P26038 | S527 | Sugiyama | MSN | ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE |
| P26373 | S77 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs |
| P26373 | T107 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF |
| P26641 | T287 | Sugiyama | EEF1G EF1G PRO1608 | EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL |
| P26885 | S108 | Sugiyama | FKBP2 FKBP13 | GWDQGLLGMCEGEKRKLVIPsELGyGERGAPPKIPGGATLV |
| P27348 | S45 | Sugiyama | YWHAQ | CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI |
| P27708 | S1859 | Sugiyama | CAD | RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP |
| P27797 | T34 | Sugiyama | CALR CRTC | LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG |
| P27816 | T828 | Sugiyama | MAP4 | AKtttAAAVAstGPssRsPstLLPKKPTAIKTEGKPAEVKK |
| P28066 | S172 | Sugiyama | PSMA5 | QLFHMDPsGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLK |
| P29401 | S473 | Sugiyama | TKT | AtEKAVELAANTKGICFIRTsRPENAIIyNNNEDFQVGQAK |
| P29692 | S44 | Sugiyama | EEF1D EF1D | RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs |
| P29692 | S64 | Sugiyama | EEF1D EF1D | sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI |
| P29692 | S65 | Sugiyama | EEF1D EF1D | VILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRIA |
| P30050 | S138 | Sugiyama | RPL12 | HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG |
| P30086 | S52 | Sugiyama | PEBP1 PBP PEBP | AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD |
| P30533 | S242 | Sugiyama | LRPAP1 A2MRAP | TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD |
| P30622 | S195 | Sugiyama | CLIP1 CYLN1 RSN | AAKEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELKIG |
| P31946 | S47 | Sugiyama | YWHAB | AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI |
| P31947 | S45 | Sugiyama | SFN HME1 | FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI |
| P33240 | S336 | Sugiyama | CSTF2 | PtPRGLLGDAPNDPRGGtLLsVtGEVEPRGYLGPPHQGPPM |
| P33316 | S120 | Sugiyama | DUT | PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS |
| P33778 | S37 | Sugiyama | H2BC3 H2BFF HIST1H2BB | KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS |
| P33778 | S39 | Sugiyama | H2BC3 H2BFF HIST1H2BB | ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA |
| P34931 | S42 | Sugiyama | HSPA1L | VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA |
| P35269 | T154 | Sugiyama | GTF2F1 RAP74 | AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF |
| P35659 | S301 | Sugiyama | DEK | NVKKADSSTTKKNQNSSKKEsEsEDssDDEPLIKKLKKPPT |
| P35659 | S303 | Sugiyama | DEK | KKADSSTTKKNQNSSKKEsEsEDssDDEPLIKKLKKPPTDE |
| P37108 | S25 | Sugiyama | SRP14 | EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt |
| P37802 | S163 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG |
| P37802 | S185 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______ |
| P37837 | S13 | Sugiyama | TALDO1 TAL TALDO TALDOR | ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA |
| P38646 | S148 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | YDDPEVQKDIKNVPFKIVRAsNGDAWVEAHGKLYSPSQIGA |
| P38646 | S89 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA |
| P39023 | S13 | Sugiyama | RPL3 OK/SW-cl.32 | ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP |
| P39023 | S265 | Sugiyama | RPL3 OK/SW-cl.32 | HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY |
| P41567 | T45 | Sugiyama | EIF1 SUI1 | AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK |
| P43243 | S188 | Sugiyama | MATR3 KIAA0723 | EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs |
| P43487 | S60 | Sugiyama | RANBP1 | TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH |
| P45974 | S783 | Sugiyama | USP5 ISOT | IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL |
| P46777 | S224 | Sugiyama | RPL5 MSTP030 | VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH |
| P46779 | S115 | Sugiyama | RPL28 | HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK |
| P46937 | S109 | Sugiyama | YAP1 YAP65 | RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP |
| P47712 | S727 | Sugiyama | PLA2G4A CPLA2 PLA2G4 | VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP |
| P48741 | S42 | Sugiyama | HSPA7 HSP70B | VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA |
| P49419 | S84 | Sugiyama | ALDH7A1 ATQ1 | EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD |
| P49841 | S9 | SIGNOR | GSK3B | ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS |
| P50454 | S139 | Sugiyama | SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 | SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS |
| P51116 | S601 | Sugiyama | FXR2 FMR1L2 | RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ |
| P51812 | S432 | Sugiyama | RPS6KA3 ISPK1 MAPKAPK1B RSK2 | HRNsIQFTDGYEVKEDIGVGsysVCKRCIHKATNMEFAVKI |
| P51812 | S434 | Sugiyama | RPS6KA3 ISPK1 MAPKAPK1B RSK2 | NsIQFTDGYEVKEDIGVGsysVCKRCIHKATNMEFAVKIID |
| P51812 | S78 | Sugiyama | RPS6KA3 ISPK1 MAPKAPK1B RSK2 | EGHEKADPsQFELLKVLGQGsFGKVFLVKKISGSDARQLYA |
| P51858 | S107 | Sugiyama | HDGF HMG1L2 | WEIENNPtVKASGYQSsQKKsCVEEPEPEPEAAEGDGDKKG |
| P53365 | S260 | Sugiyama | ARFIP2 POR1 | TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA |
| P53365 | S74 | Sugiyama | ARFIP2 POR1 | GYGGSGDGLIPTGSGRHPSHsTtPSGPGDEVARGIAGEKFD |
| P53396 | S455 | Sugiyama | ACLY | ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP |
| P53396 | S656 | Sugiyama | ACLY | IGNTGGMLDNILASKLyRPGsVAyVSRsGGMsNELNNIISR |
| P53999 | S9 | Sugiyama | SUB1 PC4 RPO2TC1 | ____________MPKSKELVsssssGsDsDsEVDKKLKRKK |
| P54652 | S41 | Sugiyama | HSPA2 | VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA |
| P57053 | S37 | Sugiyama | H2BC12L H2BFS H2BS1 | KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| P57053 | S39 | Sugiyama | H2BC12L H2BFS H2BS1 | VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| P58876 | S37 | Sugiyama | H2BC5 H2BFB HIRIP2 HIST1H2BD | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| P58876 | S39 | Sugiyama | H2BC5 H2BFB HIRIP2 HIST1H2BD | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| P60174 | S195 | Sugiyama | TPI1 TPI | KtATPQQAQEVHEKLRGWLKsNVsDAVAQstRIIyGGsVtG |
| P60174 | S21 | Sugiyama | TPI1 TPI | MAPSRKFFVGGNWKMNGRKQsLGELIGtLNAAKVPADtEVV |
| P60174 | S212 | Sugiyama | TPI1 TPI | WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV |
| P60660 | S30 | Sugiyama | MYL6 | AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK |
| P60709 | S199 | Sugiyama | ACTB | DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV |
| P60709 | S368 | Sugiyama | ACTB | sLstFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P60709 | S52 | Sugiyama | ACTB | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P60900 | S175 | Sugiyama | PSMA6 PROS27 | DPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTV |
| P61024 | S39 | Sugiyama | CKS1B CKS1 PNAS-143 PNAS-16 | yRHVMLPKDIAKLVPKTHLMsEsEWRNLGVQQsQGWVHyMI |
| P61081 | S175 | Sugiyama | UBE2M UBC12 | NNRRLFEQNVQRSMRGGyIGstyFERCLK____________ |
| P61221 | Y594 | Sugiyama | ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 | RPRINKLNsIKDVEQKKsGNyFFLDD_______________ |
| P61247 | S236 | Sugiyama | RPS3A FTE1 MFTL | KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy |
| P61313 | S100 | Sugiyama | RPL15 EC45 TCBAP0781 | tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW |
| P61916 | S29 | Sugiyama | NPC2 HE1 | LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL |
| P61978 | S75 | Sugiyama | HNRNPK HNRPK | GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE |
| P61981 | S46 | Sugiyama | YWHAG | AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI |
| P62249 | S9 | Sugiyama | RPS16 | ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN |
| P62258 | S46 | Sugiyama | YWHAE | SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI |
| P62263 | S137 | Sugiyama | RPS14 PRO2640 | RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______ |
| P62277 | S12 | Sugiyama | RPS13 | _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD |
| P62701 | S204 | Sugiyama | RPS4X CCG2 RPS4 SCAR | tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN |
| P62736 | S54 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P62807 | S37 | Sugiyama | H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI | KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss |
| P62807 | S39 | Sugiyama | H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI | VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA |
| P62899 | S15 | Sugiyama | RPL31 | ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG |
| P62906 | S64 | Sugiyama | RPL10A NEDD6 | QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH |
| P62917 | S130 | Sugiyama | RPL8 | GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL |
| P62979 | S123 | Sugiyama | RPS27A UBA80 UBCEP1 | LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK |
| P62979 | S57 | Sugiyama | RPS27A UBA80 UBCEP1 | PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA |
| P62987 | S57 | Sugiyama | UBA52 UBCEP2 | PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI |
| P63104 | S45 | Sugiyama | YWHAZ | CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI |
| P63104 | T30 | Sugiyama | YWHAZ | AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN |
| P63220 | S68 | Sugiyama | RPS21 | GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____ |
| P63261 | S199 | Sugiyama | ACTG1 ACTG | DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV |
| P63261 | S368 | Sugiyama | ACTG1 ACTG | sLstFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P63261 | S52 | Sugiyama | ACTG1 ACTG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P63267 | S53 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P67809 | S102 | Sugiyama | YBX1 NSEP1 YB1 | EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA |
| P67809 | S136 | Sugiyama | YBX1 NSEP1 YB1 | GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR |
| P67809 | S209 | Sugiyama | YBX1 NSEP1 YB1 | RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ |
| P67809 | Y99 | Sugiyama | YBX1 NSEP1 YB1 | DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG |
| P68032 | S54 | Sugiyama | ACTC1 ACTC | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68133 | S54 | Sugiyama | ACTA1 ACTA | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P78346 | S251 | Sugiyama | RPP30 RNASEP2 | HGETRKTAFGIIsTVKKPRPsEGDEDCLPAsKKAKCEG___ |
| P78371 | S143 | Sugiyama | CCT2 99D8.1 CCTB | PQTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIA |
| P78371 | S144 | Sugiyama | CCT2 99D8.1 CCTB | QTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIAG |
| P83731 | S7 | Sugiyama | RPL24 | ______________MKVELCsFsGyKIYPGHGRRYARTDGK |
| P84098 | S12 | Sugiyama | RPL19 | _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI |
| Q00587 | S350 | Sugiyama | CDC42EP1 BORG5 CEP1 MSE55 | HyPEMDARQERVEVLPQARAsWEsLDEEWRAPQAGsRtPVP |
| Q02543 | S123 | Sugiyama | RPL18A | AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK |
| Q02818 | S193 | Sugiyama | NUCB1 NUC | HEEFKRyEMLKEHERRRyLEsLGEEQRKEAERKLEEQQRRH |
| Q02952 | S629 | Sugiyama | AKAP12 AKAP250 | PWAsFKKMVtPKKRVRRPsEsDKEDELDKVKsAtLsstEst |
| Q04917 | S46 | Sugiyama | YWHAH YWHA1 | AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI |
| Q06830 | S152 | Sugiyama | PRDX1 PAGA PAGB TDPX2 | IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV |
| Q07021 | S106 | Sugiyama | C1QBP GC1QBP HABP1 SF2P32 | LsDEIKEERKIQKHKTLPKMsGGWELELNGTEAKLVRKVAG |
| Q07021 | S213 | Sugiyama | C1QBP GC1QBP HABP1 SF2P32 | VGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDSLDW |
| Q07866 | S521 | Sugiyama | KLC1 KLC KNS2 | VHKQRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEE |
| Q07866 | S524 | Sugiyama | KLC1 KLC KNS2 | QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM |
| Q09028 | S147 | Sugiyama | RBBP4 RBAP48 | VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC |
| Q09161 | S22 | Sugiyama | NCBP1 CBP80 NCBP | SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS |
| Q09472 | S89 | SIGNOR|PSP | EP300 P300 | GMVQDAASKHKQLSELLRsGssPNLNMGVGGPGQVMAsQAQ |
| Q09666 | S135 | Sugiyama | AHNAK PM227 | sGDDEEyQRIYttKIKPRLKsEDGVEGDLGEtQsRTITVTR |
| Q12982 | S114 | Sugiyama | BNIP2 NIP2 | EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR |
| Q13247 | S301 | Sugiyama | SRSF6 SFRS6 SRP55 | PKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKR |
| Q13428 | S85 | Sugiyama | TCOF1 | AEEDAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRL |
| Q13442 | S60 | Sugiyama | PDAP1 HASPP28 | QKEGGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGL |
| Q13442 | S63 | Sugiyama | PDAP1 HASPP28 | GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI |
| Q13442 | T18 | Sugiyama | PDAP1 HASPP28 | ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE |
| Q13884 | S225 | Sugiyama | SNTB1 SNT2B1 | sPVsEIGWEtPPPEsPRLGGstsDPPssQsFsFHRDRKSIP |
| Q14152 | S1028 | Sugiyama | EIF3A EIF3S10 KIAA0139 | NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP |
| Q14152 | S584 | Sugiyama | EIF3A EIF3S10 KIAA0139 | EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV |
| Q14152 | S988 | Sugiyama | EIF3A EIF3S10 KIAA0139 | PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN |
| Q14320 | S292 | Sugiyama | FAM50A DXS9928E HXC26 XAP5 | ARGKsGPLFNFDVHDDVRLLsDATVEKDESHAGKVVLRSWY |
| Q14568 | S50 | Sugiyama | HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 | MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL |
| Q14671 | S709 | Sugiyama | PUM1 KIAA0099 PUMH1 | LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH |
| Q14697 | S169 | Sugiyama | GANAB G2AN KIAA0088 | IILTARPFRLDLLEDRSLLLsVNARGLLEFEHQRAPRVsQG |
| Q14697 | S190 | Sugiyama | GANAB G2AN KIAA0088 | VNARGLLEFEHQRAPRVsQGsKDPAEGDGAQPEEtPRDGDK |
| Q14847 | S146 | Sugiyama | LASP1 MLN50 | FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt |
| Q14847 | S99 | Sugiyama | LASP1 MLN50 | ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN |
| Q15054 | S409 | Sugiyama | POLD3 KIAA0039 | SKTYLDGEGCIVTEKVyEsEsCtDsEEELNMKTSsVHRPPA |
| Q15080 | S67 | Sugiyama | NCF4 SH3PXD4 | TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP |
| Q15149 | S4386 | Sugiyama | PLEC PLEC1 | ItEFADMLsGNAGGFRsRsssVGssssyPIsPAVsRtQLAs |
| Q15185 | S72 | Sugiyama | PTGES3 P23 TEBP | EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE |
| Q15349 | S425 | Sugiyama | RPS6KA2 MAPKAPK1C RSK3 | HGNNIHFTDGYEIKEDIGVGsysVCKRCVHKAtDTEYAVKI |
| Q15349 | S427 | Sugiyama | RPS6KA2 MAPKAPK1C RSK3 | NNIHFTDGYEIKEDIGVGsysVCKRCVHKAtDTEYAVKIID |
| Q15418 | S72 | Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | AGSEKADPSHFELLKVLGQGsFGKVFLVRKVTRPDSGHLYA |
| Q15428 | S153 | Sugiyama | SF3A2 SAP62 | LFQIDYPEIAEGIMPRHRFMsAyEQRIEPPDRRWQYLLMAA |
| Q15527 | S183 | Sugiyama | SURF2 | sDDsMtDLYPPELFTRKDLGstEDGDGtDDFLtDKEDEKAK |
| Q16204 | S323 | Sugiyama | CCDC6 D10S170 TST1 | RLQRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQ |
| Q16204 | S325 | Sugiyama | CCDC6 D10S170 TST1 | QRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQGL |
| Q16513 | S583 | Sugiyama | PKN2 PRK2 PRKCL2 | VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs |
| Q16576 | S146 | Sugiyama | RBBP7 RBAP46 | VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC |
| Q16778 | S37 | Sugiyama | H2BC21 H2BFQ HIST2H2BE | KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss |
| Q16778 | S39 | Sugiyama | H2BC21 H2BFQ HIST2H2BE | VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA |
| Q27J81 | S1227 | Sugiyama | INF2 C14orf151 C14orf173 | LPRARGRASKGTGKRRKKRPsRsQEEVPPDsDDNKTKKLCV |
| Q4G0J3 | S258 | Sugiyama | LARP7 HDCMA18P | EENMDtsNtsIsKMKRsRPtsEGsDIEstEPQKQCSKKKKK |
| Q4G0J3 | S300 | Sugiyama | LARP7 HDCMA18P | DRVEAssLPEVRTGKRKRsssEDAEsLAPRSKVKKIIQKDI |
| Q58FF6 | S34 | Sugiyama | HSP90AB4P | IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN |
| Q58FF7 | S58 | Sugiyama | HSP90AB3P HSP90BC | IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN |
| Q58FF8 | S58 | Sugiyama | HSP90AB2P HSP90BB | IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN |
| Q5BKZ1 | S130 | Sugiyama | ZNF326 ZIRD | RFESSYRNsLDsFGGRNQGGssWEAPysRSKLRPGFMEDRG |
| Q5QNW6 | S37 | Sugiyama | H2BC18 HIST2H2BF | KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q5QNW6 | S39 | Sugiyama | H2BC18 HIST2H2BF | VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q5SW79 | S881 | Sugiyama | CEP170 FAM68A KAB KIAA0470 | sstPssLALtsAsRIRERsEsLDPDssMDTtLILKDTEAVM |
| Q5T0N5 | S488 | Sugiyama | FNBP1L C1orf39 TOCA1 | NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD |
| Q5T1M5 | S1162 | Sugiyama | FKBP15 KIAA0674 | EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP |
| Q5VUE5 | S67 | Sugiyama | C1orf53 | GNCGGSAPSTPGRPERAARPsVSEELTAAERQIAELHAAAC |
| Q6DN03 | S37 | Sugiyama | H2BC20P HIST2H2BC | KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC |
| Q6DN03 | S39 | Sugiyama | H2BC20P HIST2H2BC | VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA |
| Q6DRA6 | S37 | Sugiyama | H2BC19P HIST2H2BD | KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC |
| Q6DRA6 | S39 | Sugiyama | H2BC19P HIST2H2BD | VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA |
| Q6FI81 | S305 | Sugiyama | CIAPIN1 CUA001 PRO0915 | CAsCPyLGMPAFKPGEKVLLsDsNLHDA_____________ |
| Q6GYQ0 | S797 | Sugiyama | RALGAPA1 GARNL1 KIAA0884 TULIP1 | EtGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDM |
| Q6P996 | S722 | Sugiyama | PDXDC1 KIAA0251 | PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI |
| Q6PKG0 | S853 | Sugiyama | LARP1 KIAA0731 LARP | GWVMDSREHRPRtAsIsssPsEGtPtVGsyGCtPQsLPKFQ |
| Q6S8J3 | S1068 | Sugiyama | POTEE A26C1A POTE2 | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| Q6ZMR3 | S161 | Sugiyama | LDHAL6A LDHL2 | DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH |
| Q6ZN18 | S206 | Sugiyama | AEBP2 | DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS |
| Q7KZ85 | S125 | Sugiyama | SUPT6H KIAA0162 SPT6H | EENLGVKVKRGQKYRRVKKMsDDEDDDEEEYGKEEHEKEAI |
| Q7KZF4 | S150 | Sugiyama | SND1 TDRD11 | EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS |
| Q7Z4V5 | S395 | Sugiyama | HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 | REDDEPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKK |
| Q7Z4V5 | S399 | Sugiyama | HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 | EPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKKPQSS |
| Q7Z4V5 | S454 | Sugiyama | HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 | VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK |
| Q7Z5L9 | S240 | Sugiyama | IRF2BP2 | AAASLGSAQPTDLGAHKRPAsVsssAAVEHEQREAAAKEKQ |
| Q86UE4 | S494 | Sugiyama | MTDH AEG1 LYRIC | PVNtsKTRPKQEKAFSLKtIstsDPAEVLVKNSQPIKTLPP |
| Q86UU0 | S118 | Sugiyama | BCL9L DLNB11 | QAGVPPFssLKGKVKRDRsVsVDsGEQREAGtPsLDSEAKE |
| Q86VQ1 | S223 | Sugiyama | GLCCI1 | QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR |
| Q86W56 | Y832 | Sugiyama | PARG | DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF |
| Q8IZ21 | S590 | Sugiyama | PHACTR4 PRO2963 | SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA |
| Q8N257 | S37 | Sugiyama | H2BC26 H2BU1 HIST3H2BB | KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss |
| Q8N257 | S39 | Sugiyama | H2BC26 H2BU1 HIST3H2BB | VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA |
| Q8NBJ7 | S256 | Sugiyama | SUMF2 PSEC0171 UNQ1968/PRO4500 | EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG |
| Q8NBS9 | S285 | Sugiyama | TXNDC5 TLP46 UNQ364/PRO700 | LLWFRDGKKVDQYKGKRDLEsLREyVEsQLQRTETGATETV |
| Q8NBS9 | S426 | Sugiyama | TXNDC5 TLP46 UNQ364/PRO700 | KKVSEHSGGRDLDSLHRFVLsQAKDEL______________ |
| Q8TEH3 | S536 | Sugiyama | DENND1A FAM31A KIAA1608 | GRRtsVPsPEQPQPYRtLREsDsAEGDEAEsPEQQVRKstG |
| Q8TEH3 | T532 | Sugiyama | DENND1A FAM31A KIAA1608 | IAVEGRRtsVPsPEQPQPYRtLREsDsAEGDEAEsPEQQVR |
| Q8TEW0 | S962 | Sugiyama | PARD3 PAR3 PAR3A | DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ |
| Q8WWI1 | S704 | Sugiyama | LMO7 FBX20 FBXO20 KIAA0858 | KKRLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEM |
| Q92597 | S330 | Sugiyama | NDRG1 CAP43 DRG1 RTP | QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT |
| Q92734 | S50 | Sugiyama | TFG | DITyDELVLMMQRVFRGKLLsNDEVTIKYKDEDGDLITIFD |
| Q92766 | S1167 | Sugiyama | RREB1 FINB | AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT |
| Q93079 | S37 | Sugiyama | H2BC9 H2BFJ HIST1H2BH | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q93079 | S39 | Sugiyama | H2BC9 H2BFJ HIST1H2BH | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q96CV9 | S526 | Sugiyama | OPTN FIP2 GLC1E HIP7 HYPL NRP | FEDGGRQsLMEMQsRHGARtsDsDQQAyLVQRGAEDRDWRQ |
| Q96G46 | T240 | Sugiyama | DUS3L | KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC |
| Q96T58 | S1268 | Sugiyama | SPEN KIAA0929 MINT SHARP | SRQISEDsERtGGsPsVRHGsFHEDEDPIGsPRLLSVKGsP |
| Q99613 | S865 | Sugiyama | EIF3C EIF3S8 | HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF |
| Q99877 | S37 | Sugiyama | H2BC15 H2BFD HIST1H2BN | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q99877 | S39 | Sugiyama | H2BC15 H2BFD HIST1H2BN | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q99879 | S37 | Sugiyama | H2BC14 H2BFE HIST1H2BM | KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q99879 | S39 | Sugiyama | H2BC14 H2BFE HIST1H2BM | INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q99880 | S37 | Sugiyama | H2BC13 H2BFC HIST1H2BL | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q99880 | S39 | Sugiyama | H2BC13 H2BFC HIST1H2BL | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q9BW71 | S357 | Sugiyama | HIRIP3 | EDsGKGEPTAKGSRKMARLGstsGEEsDLEREVsDsEAGGG |
| Q9BY44 | S526 | Sugiyama | EIF2A CDA02 MSTP004 MSTP089 | sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA |
| Q9BYX7 | S368 | Sugiyama | POTEKP ACTBL3 FKSG30 | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| Q9BZI7 | S166 | Sugiyama | UPF3B RENT3B UPF3X | KRDTKVGtIDDDPEyRKFLEsyAtDNEKMTstPEtLLEEIE |
| Q9C0C2 | S1620 | Sugiyama | TNKS1BP1 KIAA1741 TAB182 | ADsDAHLFQDSTEPRAsRVPssDEEVVEEPQsRRTRMsLGT |
| Q9C0C2 | S429 | Sugiyama | TNKS1BP1 KIAA1741 TAB182 | EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA |
| Q9H0L4 | S344 | Sugiyama | CSTF2T KIAA0689 | LPPRGLLGDAPNDPRGGtLLsVtGEVEPRGYLGPPHQGPPM |
| Q9H2G2 | S1229 | Sugiyama | SLK KIAA0204 STK2 | EsECLNPStQsRISKFyPIPsLHstGs______________ |
| Q9H2U2 | S313 | Sugiyama | PPA2 HSPC124 | VQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLG |
| Q9H3Q1 | S309 | Sugiyama | CDC42EP4 BORG4 CEP4 | AAPsPGsARSMGSHTTRDSSsLssCtsGILEERsPAFRGPD |
| Q9H788 | S315 | Sugiyama | SH2D4A PPP1R38 SH2A | LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA |
| Q9H7D7 | S121 | Sugiyama | WDR26 CDW2 MIP2 PRO0852 | ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN |
| Q9H7D7 | S123 | Sugiyama | WDR26 CDW2 MIP2 PRO0852 | SSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLNQT |
| Q9H7E2 | S364 | Sugiyama | TDRD3 | KsVLEGSGLPRNRGsERPSTssVsEVWAEDRIKCDRPYSRY |
| Q9H7E2 | S365 | Sugiyama | TDRD3 | sVLEGSGLPRNRGsERPSTssVsEVWAEDRIKCDRPYSRYD |
| Q9HA77 | T546 | Sugiyama | CARS2 OK/SW-cl.10 | CDTLRRGLTAHGINIKDRssttstWELLDQRTKDQKSAG__ |
| Q9HAU0 | S471 | Sugiyama | PLEKHA5 KIAA1686 PEPP2 | MARYPEGYRtLPRNSKTRPEsICSVtPsTHDKTLGPGAEEK |
| Q9NP61 | S367 | Sugiyama | ARFGAP3 ARFGAP1 | DsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKDT |
| Q9NTI5 | S1257 | Sugiyama | PDS5B APRIN AS3 KIAA0979 | LVQEQKPKGSQRSRKRGHtAsEsDEQQWPEEKRLKEDILEN |
| Q9NW13 | S200 | Sugiyama | RBM28 | KGRTVAVDWAVAKDKYKDTQsVsAIGEEKSHESKHQESVKK |
| Q9NY33 | S130 | Sugiyama | DPP3 | GDTKFVPNLPKEKLERVILGsEAAQQHPEEVRGLWQTCGEL |
| Q9NZL9 | S16 | Sugiyama | MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995 | _____MVGREKELsIHFVPGsCRLVEEEVNIPNRRVLVtGA |
| Q9NZL9 | S9 | Sugiyama | MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995 | ____________MVGREKELsIHFVPGsCRLVEEEVNIPNR |
| Q9NZZ3 | S16 | Sugiyama | CHMP5 C9orf83 SNF7DC2 CGI-34 HSPC177 PNAS-114 PNAS-2 | _____MNRLFGKAKPKAPPPsLtDCIGtVDsRAEsIDKKIS |
| Q9UBP6 | S27 | Sugiyama | METTL1 C12orf1 | NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS |
| Q9UGV2 | S331 | Sugiyama | NDRG3 | QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ |
| Q9UI15 | S185 | Sugiyama | TAGLN3 NP25 | EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______ |
| Q9UK32 | S19 | Sugiyama | RPS6KA6 RSK4 | __MLPFAPQDEPWDREMEVFsGGGAssGEVNGLKMVDEPME |
| Q9UK32 | S223 | Sugiyama | RPS6KA6 RSK4 | NILLDEIGHIKLTDFGLSKEsVDQEKKAysFCGtVEYMAPE |
| Q9UK32 | S232 | SIGNOR|PSP | RPS6KA6 RSK4 | IKLTDFGLSKEsVDQEKKAysFCGtVEYMAPEVVNRRGHSQ |
| Q9UK32 | S24 | Sugiyama | RPS6KA6 RSK4 | FAPQDEPWDREMEVFsGGGAssGEVNGLKMVDEPMEEGEAD |
| Q9UK32 | S25 | Sugiyama | RPS6KA6 RSK4 | APQDEPWDREMEVFsGGGAssGEVNGLKMVDEPMEEGEADs |
| Q9UK32 | S318 | Sugiyama | RPS6KA6 RSK4 | AEAQSLLRMLFKRNPANRLGsEGVEEIKRHLFFANIDWDKL |
| Q9UK32 | S372 | Sugiyama | RPS6KA6 RSK4 | GKPDDTFCFDPEFTAKTPKDsPGLPAsANAHQLFKGFsFVA |
| Q9UK32 | S378 | Sugiyama | RPS6KA6 RSK4 | FCFDPEFTAKTPKDsPGLPAsANAHQLFKGFsFVAtsIAEE |
| Q9UK32 | S389 | Sugiyama | RPS6KA6 RSK4 | PKDsPGLPAsANAHQLFKGFsFVAtsIAEEYKITPITSANV |
| Q9UK32 | S394 | Sugiyama | RPS6KA6 RSK4 | GLPAsANAHQLFKGFsFVAtsIAEEYKITPITSANVLPIVQ |
| Q9UK32 | S436 | Sugiyama | RPS6KA6 RSK4 | NGNAAQFGEVYELKEDIGVGsysVCKRCIHATTNMEFAVKI |
| Q9UK32 | S438 | Sugiyama | RPS6KA6 RSK4 | NAAQFGEVYELKEDIGVGsysVCKRCIHATTNMEFAVKIID |
| Q9UK32 | S45 | Sugiyama | RPS6KA6 RSK4 | sGEVNGLKMVDEPMEEGEADsCHDEGVVKEIPItHHVKEGY |
| Q9UK32 | S465 | Sugiyama | RPS6KA6 RSK4 | HATTNMEFAVKIIDKSKRDPsEEIEILMRYGQHPNIITLKD |
| Q9UK32 | S547 | Sugiyama | RPS6KA6 RSK4 | ISKTVDYLHCQGVVHRDLKPsNILYMDEsASADsIRICDFG |
| Q9UK32 | S555 | Sugiyama | RPS6KA6 RSK4 | HCQGVVHRDLKPsNILYMDEsASADsIRICDFGFAKQLRGE |
| Q9UK32 | S560 | Sugiyama | RPS6KA6 RSK4 | VHRDLKPsNILYMDEsASADsIRICDFGFAKQLRGENGLLL |
| Q9UK32 | S643 | Sugiyama | RPS6KA6 RSK4 | ANGPNDTPEEILLRIGNGKFsLSGGNWDNISDGAKDLLSHM |
| Q9UK32 | S712 | Sugiyama | RPS6KA6 RSK4 | DQPKRNDVSHVVKGAMVAtysALtHKtFQPVLEPVAAssLA |
| Q9UK32 | S729 | Sugiyama | RPS6KA6 RSK4 | AtysALtHKtFQPVLEPVAAssLAQRRSMKKRTSTGL____ |
| Q9UK32 | S730 | Sugiyama | RPS6KA6 RSK4 | tysALtHKtFQPVLEPVAAssLAQRRSMKKRTSTGL_____ |
| Q9UK32 | S83 | Sugiyama | RPS6KA6 RSK4 | EGYEKADPAQFELLKVLGQGsFGKVFLVRKKTGPDAGQLYA |
| Q9UK32 | T393 | Sugiyama | RPS6KA6 RSK4 | PGLPAsANAHQLFKGFsFVAtsIAEEYKITPITSANVLPIV |
| Q9UK32 | T58 | Sugiyama | RPS6KA6 RSK4 | MEEGEADsCHDEGVVKEIPItHHVKEGYEKADPAQFELLKV |
| Q9UK32 | T710 | Sugiyama | RPS6KA6 RSK4 | PNDQPKRNDVSHVVKGAMVAtysALtHKtFQPVLEPVAAss |
| Q9UK32 | T715 | Sugiyama | RPS6KA6 RSK4 | KRNDVSHVVKGAMVAtysALtHKtFQPVLEPVAAssLAQRR |
| Q9UK32 | T718 | Sugiyama | RPS6KA6 RSK4 | DVSHVVKGAMVAtysALtHKtFQPVLEPVAAssLAQRRSMK |
| Q9UK32 | Y711 | Sugiyama | RPS6KA6 RSK4 | NDQPKRNDVSHVVKGAMVAtysALtHKtFQPVLEPVAAssL |
| Q9UKV3 | S551 | Sugiyama | ACIN1 ACINUS KIAA0670 | LKIEELALAKGITEECLKQPsLEQKEGRRAsHtLLPSHRLK |
| Q9ULD2 | S1203 | Sugiyama | MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 | QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL |
| Q9UQ35 | S1455 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | PsRRsRsGssPGLRDGsGtPsRHsLsGssPGMKDIPRtPSR |
| Q9UQ35 | S1539 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs |
| Q9UQ35 | S1541 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs |
| Q9Y2B0 | S65 | Sugiyama | CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 | VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI |
| Q9Y2I7 | S307 | Sugiyama | PIKFYVE KIAA0981 PIP5K3 | TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts |
| Q9Y2T7 | S137 | Sugiyama | YBX2 CSDA3 MSY2 | EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA |
| Q9Y5S9 | S56 | Sugiyama | RBM8A RBM8 HSPC114 MDS014 | KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF |
| Q9Y6X9 | S739 | Sugiyama | MORC2 KIAA0852 ZCWCC1 | VVKKtEsPIKLsPAtPsRKRsVAVsDEEEVEEEAERRKERC |
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| Chromatin organization | R-HSA-4839726 | 2.545320e-11 | 10.594 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 3.386924e-11 | 10.470 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 1.552697e-09 | 8.809 | 0 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 2.167781e-09 | 8.664 | 0 | 0 |
| Cell Cycle | R-HSA-1640170 | 1.461040e-07 | 6.835 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 3.004800e-07 | 6.522 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 2.969997e-07 | 6.527 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 3.528101e-07 | 6.452 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 4.412096e-07 | 6.355 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 5.033063e-07 | 6.298 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 8.696150e-07 | 6.061 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 8.929528e-07 | 6.049 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 1.189305e-06 | 5.925 | 0 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 1.688696e-06 | 5.772 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 2.367180e-06 | 5.626 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 2.403833e-06 | 5.619 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 3.367707e-06 | 5.473 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 3.537618e-06 | 5.451 | 0 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 6.286560e-06 | 5.202 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 7.829118e-06 | 5.106 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 1.025086e-05 | 4.989 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 1.020231e-05 | 4.991 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 1.112740e-05 | 4.954 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 1.154762e-05 | 4.938 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 1.281293e-05 | 4.892 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 1.309133e-05 | 4.883 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 1.410081e-05 | 4.851 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 1.519620e-05 | 4.818 | 0 | 0 |
| DNA methylation | R-HSA-5334118 | 1.702734e-05 | 4.769 | 0 | 0 |
| Signal Transduction | R-HSA-162582 | 1.693227e-05 | 4.771 | 0 | 0 |
| M Phase | R-HSA-68886 | 1.779683e-05 | 4.750 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 1.819924e-05 | 4.740 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 2.189168e-05 | 4.660 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 3.008850e-05 | 4.522 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 3.317393e-05 | 4.479 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 3.572411e-05 | 4.447 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 5.180054e-05 | 4.286 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 5.481586e-05 | 4.261 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 6.593177e-05 | 4.181 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 6.785792e-05 | 4.168 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 7.274593e-05 | 4.138 | 0 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 7.480617e-05 | 4.126 | 0 | 0 |
| FOXO-mediated transcription of cell cycle genes | R-HSA-9617828 | 8.192870e-05 | 4.087 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 8.144169e-05 | 4.089 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 1.032234e-04 | 3.986 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 1.040801e-04 | 3.983 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 1.121515e-04 | 3.950 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 1.107443e-04 | 3.956 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 1.258575e-04 | 3.900 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 1.499937e-04 | 3.824 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 1.462262e-04 | 3.835 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 1.459359e-04 | 3.836 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 1.546943e-04 | 3.811 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 1.631818e-04 | 3.787 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 1.672419e-04 | 3.777 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 1.672419e-04 | 3.777 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 1.793718e-04 | 3.746 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 1.984768e-04 | 3.702 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 1.983228e-04 | 3.703 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 1.854209e-04 | 3.732 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 2.000340e-04 | 3.699 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 2.086313e-04 | 3.681 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 2.114972e-04 | 3.675 | 0 | 0 |
| Meiosis | R-HSA-1500620 | 2.343564e-04 | 3.630 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 3.284452e-04 | 3.484 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 3.237218e-04 | 3.490 | 0 | 0 |
| RUNX1 regulates expression of components of tight junctions | R-HSA-8935964 | 3.498651e-04 | 3.456 | 0 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 3.674080e-04 | 3.435 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 3.910340e-04 | 3.408 | 0 | 0 |
| Germ layer formation at gastrulation | R-HSA-9754189 | 5.125456e-04 | 3.290 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 4.952938e-04 | 3.305 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 5.044669e-04 | 3.297 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 5.182212e-04 | 3.285 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 5.318799e-04 | 3.274 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 6.280645e-04 | 3.202 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 6.492883e-04 | 3.188 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 6.643079e-04 | 3.178 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 6.643079e-04 | 3.178 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 7.018413e-04 | 3.154 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 7.752807e-04 | 3.111 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 7.518036e-04 | 3.124 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 7.928823e-04 | 3.101 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 8.889915e-04 | 3.051 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 9.865208e-04 | 3.006 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 1.005692e-03 | 2.998 | 1 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 1.026080e-03 | 2.989 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 1.100209e-03 | 2.959 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 1.122401e-03 | 2.950 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 1.066833e-03 | 2.972 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 1.087589e-03 | 2.964 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 1.123556e-03 | 2.949 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 1.179162e-03 | 2.928 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 1.203975e-03 | 2.919 | 0 | 0 |
| Regulation of TP53 Expression | R-HSA-6804754 | 1.212609e-03 | 2.916 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 1.247405e-03 | 2.904 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 1.349815e-03 | 2.870 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 1.349815e-03 | 2.870 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 1.374800e-03 | 2.862 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 1.625194e-03 | 2.789 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 1.691414e-03 | 2.772 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 1.772024e-03 | 2.752 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 1.891486e-03 | 2.723 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 2.007096e-03 | 2.697 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 2.295349e-03 | 2.639 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 2.313247e-03 | 2.636 | 0 | 0 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | 2.382245e-03 | 2.623 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 2.459509e-03 | 2.609 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 2.461758e-03 | 2.609 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 2.487013e-03 | 2.604 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 2.731016e-03 | 2.564 | 0 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 2.760976e-03 | 2.559 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 2.875087e-03 | 2.541 | 1 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 3.301031e-03 | 2.481 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 3.613501e-03 | 2.442 | 0 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 3.730330e-03 | 2.428 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 4.111869e-03 | 2.386 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 4.084186e-03 | 2.389 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 4.175692e-03 | 2.379 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | R-HSA-9825892 | 4.202883e-03 | 2.376 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 4.240760e-03 | 2.373 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 4.251097e-03 | 2.371 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 4.335429e-03 | 2.363 | 0 | 0 |
| Transcriptional activation of p53 responsive genes | R-HSA-69560 | 5.143393e-03 | 2.289 | 0 | 0 |
| Transcriptional activation of cell cycle inhibitor p21 | R-HSA-69895 | 5.143393e-03 | 2.289 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 4.933608e-03 | 2.307 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 4.920959e-03 | 2.308 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 4.794033e-03 | 2.319 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 5.168495e-03 | 2.287 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 5.454350e-03 | 2.263 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 5.454350e-03 | 2.263 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 5.698254e-03 | 2.244 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 5.698254e-03 | 2.244 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 5.744986e-03 | 2.241 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | R-HSA-2892245 | 6.054275e-03 | 2.218 | 0 | 0 |
| Depurination | R-HSA-73927 | 6.124234e-03 | 2.213 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 6.383700e-03 | 2.195 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 6.383700e-03 | 2.195 | 0 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 7.214632e-03 | 2.142 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 6.752398e-03 | 2.171 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 6.921922e-03 | 2.160 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 7.226177e-03 | 2.141 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 7.643462e-03 | 2.117 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 7.662253e-03 | 2.116 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 7.852152e-03 | 2.105 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 7.866128e-03 | 2.104 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 8.142671e-03 | 2.089 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 8.142671e-03 | 2.089 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 8.726940e-03 | 2.059 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 8.901883e-03 | 2.051 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 8.500151e-03 | 2.071 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 9.064509e-03 | 2.043 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 8.504673e-03 | 2.070 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 8.316585e-03 | 2.080 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 8.901883e-03 | 2.051 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 8.657830e-03 | 2.063 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 9.253201e-03 | 2.034 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 9.862855e-03 | 2.006 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 9.862855e-03 | 2.006 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 9.862855e-03 | 2.006 | 0 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 9.928433e-03 | 2.003 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 1.091325e-02 | 1.962 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 1.091325e-02 | 1.962 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 1.141905e-02 | 1.942 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 1.270564e-02 | 1.896 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 1.304064e-02 | 1.885 | 0 | 0 |
| PKA-mediated phosphorylation of key metabolic factors | R-HSA-163358 | 1.364021e-02 | 1.865 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 1.392060e-02 | 1.856 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 1.493812e-02 | 1.826 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 1.479174e-02 | 1.830 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 1.515486e-02 | 1.819 | 0 | 0 |
| Polo-like kinase mediated events | R-HSA-156711 | 1.707734e-02 | 1.768 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 1.932239e-02 | 1.714 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 1.932239e-02 | 1.714 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 1.941834e-02 | 1.712 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 1.978894e-02 | 1.704 | 0 | 0 |
| Regulation of NFE2L2 gene expression | R-HSA-9818749 | 2.002590e-02 | 1.698 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 2.266370e-02 | 1.645 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 2.288461e-02 | 1.640 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 2.288461e-02 | 1.640 | 0 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 2.270428e-02 | 1.644 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 2.172482e-02 | 1.663 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 2.264156e-02 | 1.645 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 2.263536e-02 | 1.645 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 2.270428e-02 | 1.644 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 2.256365e-02 | 1.647 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 2.190836e-02 | 1.659 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 2.214607e-02 | 1.655 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 2.334314e-02 | 1.632 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 2.334314e-02 | 1.632 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 2.338875e-02 | 1.631 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 2.440299e-02 | 1.613 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 2.536293e-02 | 1.596 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 2.536293e-02 | 1.596 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 2.675140e-02 | 1.573 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 2.685070e-02 | 1.571 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 2.694044e-02 | 1.570 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 2.712783e-02 | 1.567 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 2.712783e-02 | 1.567 | 0 | 0 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | R-HSA-9634600 | 2.781065e-02 | 1.556 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 2.925142e-02 | 1.534 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 2.925142e-02 | 1.534 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of cell cycle factors | R-HSA-8866911 | 3.150675e-02 | 1.502 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 3.066367e-02 | 1.513 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 2.984853e-02 | 1.525 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 2.988850e-02 | 1.524 | 0 | 0 |
| Dopamine receptors | R-HSA-390651 | 3.150675e-02 | 1.502 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 3.247012e-02 | 1.489 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 3.136000e-02 | 1.504 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 3.132368e-02 | 1.504 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 3.405246e-02 | 1.468 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 3.405246e-02 | 1.468 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 3.066367e-02 | 1.513 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 3.033845e-02 | 1.518 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 3.419815e-02 | 1.466 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 3.426374e-02 | 1.465 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 3.458465e-02 | 1.461 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 3.595346e-02 | 1.444 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 3.604629e-02 | 1.443 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 3.648382e-02 | 1.438 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 3.648382e-02 | 1.438 | 0 | 0 |
| Regulation of FOXO transcriptional activity by acetylation | R-HSA-9617629 | 3.693454e-02 | 1.433 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 3.750011e-02 | 1.426 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 3.758674e-02 | 1.425 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 3.767404e-02 | 1.424 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 3.960532e-02 | 1.402 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 4.102975e-02 | 1.387 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 4.182835e-02 | 1.379 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 4.214281e-02 | 1.375 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 4.214281e-02 | 1.375 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 4.235674e-02 | 1.373 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 4.435919e-02 | 1.353 | 0 | 0 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 4.574717e-02 | 1.340 | 0 | 0 |
| Interactions of Tat with host cellular proteins | R-HSA-176034 | 4.598737e-02 | 1.337 | 0 | 0 |
| TWIK-releated acid-sensitive K+ channel (TASK) | R-HSA-1299316 | 4.598737e-02 | 1.337 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 4.612225e-02 | 1.336 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 4.656879e-02 | 1.332 | 0 | 0 |
| Inactivation of CDC42 and RAC1 | R-HSA-428543 | 4.885134e-02 | 1.311 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 4.885134e-02 | 1.311 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 4.887545e-02 | 1.311 | 0 | 0 |
| Kinesins | R-HSA-983189 | 4.946321e-02 | 1.306 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 4.946321e-02 | 1.306 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 5.214056e-02 | 1.283 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 5.271565e-02 | 1.278 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 5.929771e-02 | 1.227 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 6.248491e-02 | 1.204 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 6.341796e-02 | 1.198 | 0 | 0 |
| PTK6 Regulates Cell Cycle | R-HSA-8849470 | 6.350180e-02 | 1.197 | 0 | 0 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | 6.350180e-02 | 1.197 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 6.350180e-02 | 1.197 | 0 | 0 |
| Epithelial-Mesenchymal Transition (EMT) during gastrulation | R-HSA-9758919 | 6.350180e-02 | 1.197 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 6.422181e-02 | 1.192 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 6.456034e-02 | 1.190 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 6.538743e-02 | 1.185 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 6.607862e-02 | 1.180 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 6.681986e-02 | 1.175 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 6.681986e-02 | 1.175 | 0 | 0 |
| STAT3 nuclear events downstream of ALK signaling | R-HSA-9701898 | 6.681986e-02 | 1.175 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 6.733093e-02 | 1.172 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 6.753984e-02 | 1.170 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 6.825002e-02 | 1.166 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 7.042250e-02 | 1.152 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 7.357333e-02 | 1.133 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 7.424680e-02 | 1.129 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 7.446409e-02 | 1.128 | 0 | 0 |
| Regulation of cortical dendrite branching | R-HSA-8985801 | 7.601996e-02 | 1.119 | 0 | 0 |
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | R-HSA-446343 | 7.601996e-02 | 1.119 | 0 | 0 |
| Potassium transport channels | R-HSA-1296067 | 7.601996e-02 | 1.119 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 7.907220e-02 | 1.102 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 7.907220e-02 | 1.102 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 8.903945e-02 | 1.050 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 8.157131e-02 | 1.088 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 9.007340e-02 | 1.045 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 9.007340e-02 | 1.045 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 9.007340e-02 | 1.045 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 8.243277e-02 | 1.084 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 7.547016e-02 | 1.122 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 8.139705e-02 | 1.089 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 7.769208e-02 | 1.110 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 8.761393e-02 | 1.057 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 8.334251e-02 | 1.079 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 8.424457e-02 | 1.074 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 7.894766e-02 | 1.103 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 7.958170e-02 | 1.099 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 9.007340e-02 | 1.045 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 7.616052e-02 | 1.118 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 8.157131e-02 | 1.088 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 9.085992e-02 | 1.042 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 9.085992e-02 | 1.042 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 9.085992e-02 | 1.042 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 9.085992e-02 | 1.042 | 0 | 0 |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | 9.240241e-02 | 1.034 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | R-HSA-2892247 | 9.244036e-02 | 1.034 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 9.412221e-02 | 1.026 | 0 | 0 |
| S Phase | R-HSA-69242 | 9.541013e-02 | 1.020 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 9.541013e-02 | 1.020 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 9.907792e-02 | 1.004 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 9.907792e-02 | 1.004 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 1.023766e-01 | 0.990 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 1.028406e-01 | 0.988 | 0 | 0 |
| Drug resistance of PDGFR mutants | R-HSA-9674415 | 1.068725e-01 | 0.971 | 0 | 0 |
| PDGFR mutants bind TKIs | R-HSA-9674428 | 1.068725e-01 | 0.971 | 0 | 0 |
| Imatinib-resistant PDGFR mutants | R-HSA-9674396 | 1.068725e-01 | 0.971 | 0 | 0 |
| APC truncation mutants are not K63 polyubiquitinated | R-HSA-5467333 | 1.068725e-01 | 0.971 | 0 | 0 |
| Loss of Function of TP53 in Cancer | R-HSA-9723907 | 1.068725e-01 | 0.971 | 0 | 0 |
| Regorafenib-resistant PDGFR mutants | R-HSA-9674403 | 1.068725e-01 | 0.971 | 0 | 0 |
| Sorafenib-resistant PDGFR mutants | R-HSA-9674404 | 1.068725e-01 | 0.971 | 0 | 0 |
| Loss of function of TP53 in cancer due to loss of tetramerization ability | R-HSA-9723905 | 1.068725e-01 | 0.971 | 0 | 0 |
| Sunitinib-resistant PDGFR mutants | R-HSA-9674401 | 1.068725e-01 | 0.971 | 0 | 0 |
| Signaling by FGFR1 amplification mutants | R-HSA-1839120 | 1.105307e-01 | 0.957 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 1.056891e-01 | 0.976 | 0 | 0 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 1.056891e-01 | 0.976 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 1.056891e-01 | 0.976 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 1.056891e-01 | 0.976 | 0 | 0 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | 1.099594e-01 | 0.959 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 1.288774e-01 | 0.890 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 1.288774e-01 | 0.890 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 1.288774e-01 | 0.890 | 0 | 0 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | R-HSA-9661069 | 1.288774e-01 | 0.890 | 0 | 0 |
| FOXO-mediated transcription of cell death genes | R-HSA-9614657 | 1.223665e-01 | 0.912 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 1.223665e-01 | 0.912 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 1.188788e-01 | 0.925 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 1.085808e-01 | 0.964 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 1.132283e-01 | 0.946 | 0 | 0 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 1.132283e-01 | 0.946 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 1.107059e-01 | 0.956 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 1.153975e-01 | 0.938 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 1.256996e-01 | 0.901 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 1.188788e-01 | 0.925 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 1.211865e-01 | 0.917 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 1.211865e-01 | 0.917 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 1.211865e-01 | 0.917 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 1.085808e-01 | 0.964 | 0 | 0 |
| PKA activation | R-HSA-163615 | 1.223665e-01 | 0.912 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 1.051767e-01 | 0.978 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 1.037138e-01 | 0.984 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 1.185754e-01 | 0.926 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 1.057795e-01 | 0.976 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 1.280927e-01 | 0.892 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 1.280927e-01 | 0.892 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 1.188788e-01 | 0.925 | 0 | 0 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | R-HSA-9659787 | 1.288774e-01 | 0.890 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 1.223665e-01 | 0.912 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 1.188788e-01 | 0.925 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 1.232501e-01 | 0.909 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 1.061384e-01 | 0.974 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 1.223665e-01 | 0.912 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 1.107059e-01 | 0.956 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 1.177330e-01 | 0.929 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 1.133380e-01 | 0.946 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 1.237045e-01 | 0.908 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 1.238365e-01 | 0.907 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 1.299661e-01 | 0.886 | 0 | 0 |
| Sodium/Proton exchangers | R-HSA-425986 | 1.299661e-01 | 0.886 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 1.302789e-01 | 0.885 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 1.310280e-01 | 0.883 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 2.023289e-01 | 0.694 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 2.023289e-01 | 0.694 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 2.023289e-01 | 0.694 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 2.023289e-01 | 0.694 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 2.023289e-01 | 0.694 | 0 | 0 |
| Defective DNA double strand break response due to BARD1 loss of function | R-HSA-9699150 | 2.023289e-01 | 0.694 | 0 | 0 |
| Defective DNA double strand break response due to BRCA1 loss of function | R-HSA-9663199 | 2.023289e-01 | 0.694 | 0 | 0 |
| TLR3-mediated TICAM1-dependent programmed cell death | R-HSA-9013957 | 1.482204e-01 | 0.829 | 0 | 0 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | 1.482204e-01 | 0.829 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 1.482204e-01 | 0.829 | 0 | 0 |
| NFE2L2 regulating ER-stress associated genes | R-HSA-9818035 | 1.482204e-01 | 0.829 | 0 | 0 |
| Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | R-HSA-2644607 | 1.482204e-01 | 0.829 | 0 | 0 |
| GRB7 events in ERBB2 signaling | R-HSA-1306955 | 1.482204e-01 | 0.829 | 0 | 0 |
| FBXW7 Mutants and NOTCH1 in Cancer | R-HSA-2644605 | 1.482204e-01 | 0.829 | 0 | 0 |
| PI and PC transport between ER and Golgi membranes | R-HSA-1483196 | 2.875880e-01 | 0.541 | 0 | 0 |
| TGFBR3 regulates FGF2 signaling | R-HSA-9839397 | 2.875880e-01 | 0.541 | 0 | 0 |
| TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | R-HSA-6791055 | 2.875880e-01 | 0.541 | 0 | 0 |
| SMAD4 MH2 Domain Mutants in Cancer | R-HSA-3311021 | 2.875880e-01 | 0.541 | 0 | 0 |
| Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | R-HSA-5619111 | 2.875880e-01 | 0.541 | 0 | 0 |
| Intestinal infectious diseases | R-HSA-8942233 | 2.875880e-01 | 0.541 | 0 | 0 |
| TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | R-HSA-6791462 | 2.875880e-01 | 0.541 | 0 | 0 |
| Defective SLC6A2 causes orthostatic intolerance (OI) | R-HSA-5619109 | 2.875880e-01 | 0.541 | 0 | 0 |
| IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | R-HSA-5603027 | 2.875880e-01 | 0.541 | 0 | 0 |
| Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) | R-HSA-5619050 | 2.875880e-01 | 0.541 | 0 | 0 |
| IKBKB deficiency causes SCID | R-HSA-5602636 | 2.875880e-01 | 0.541 | 0 | 0 |
| Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) | R-HSA-5619054 | 2.875880e-01 | 0.541 | 0 | 0 |
| Loss of Function of SMAD4 in Cancer | R-HSA-3304347 | 2.875880e-01 | 0.541 | 0 | 0 |
| SMAD2/3 MH2 Domain Mutants in Cancer | R-HSA-3315487 | 2.875880e-01 | 0.541 | 0 | 0 |
| Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | R-HSA-9931529 | 1.880164e-01 | 0.726 | 0 | 0 |
| NFE2L2 regulating inflammation associated genes | R-HSA-9818026 | 1.880164e-01 | 0.726 | 0 | 0 |
| IRS activation | R-HSA-74713 | 1.880164e-01 | 0.726 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 1.559790e-01 | 0.807 | 0 | 0 |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | 2.290385e-01 | 0.640 | 0 | 0 |
| SLIT2:ROBO1 increases RHOA activity | R-HSA-8985586 | 2.290385e-01 | 0.640 | 0 | 0 |
| Signaling by MAPK mutants | R-HSA-9652817 | 2.290385e-01 | 0.640 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 3.637386e-01 | 0.439 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 3.637386e-01 | 0.439 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 3.637386e-01 | 0.439 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 3.637386e-01 | 0.439 | 0 | 0 |
| HHAT G278V doesn't palmitoylate Hh-Np | R-HSA-5658034 | 3.637386e-01 | 0.439 | 0 | 0 |
| Glycogen storage disease type XV (GYG1) | R-HSA-3814836 | 3.637386e-01 | 0.439 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 3.637386e-01 | 0.439 | 0 | 0 |
| Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | R-HSA-5619049 | 3.637386e-01 | 0.439 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 3.637386e-01 | 0.439 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 3.637386e-01 | 0.439 | 0 | 0 |
| Mitotic Metaphase/Anaphase Transition | R-HSA-68881 | 3.637386e-01 | 0.439 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 3.637386e-01 | 0.439 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 3.637386e-01 | 0.439 | 0 | 0 |
| Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | R-HSA-5619089 | 3.637386e-01 | 0.439 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 3.637386e-01 | 0.439 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 3.637386e-01 | 0.439 | 0 | 0 |
| Glycogen storage disease type 0 (muscle GYS1) | R-HSA-3828062 | 3.637386e-01 | 0.439 | 0 | 0 |
| TWIK related potassium channel (TREK) | R-HSA-1299503 | 3.637386e-01 | 0.439 | 0 | 0 |
| Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) | R-HSA-5655799 | 3.637386e-01 | 0.439 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 1.834318e-01 | 0.737 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 1.490382e-01 | 0.827 | 0 | 0 |
| CREB phosphorylation | R-HSA-199920 | 2.705707e-01 | 0.568 | 0 | 0 |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | R-HSA-2980767 | 2.705707e-01 | 0.568 | 0 | 0 |
| ChREBP activates metabolic gene expression | R-HSA-163765 | 2.120344e-01 | 0.674 | 0 | 0 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 2.120344e-01 | 0.674 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 2.120344e-01 | 0.674 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 2.120344e-01 | 0.674 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 2.120344e-01 | 0.674 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 2.120344e-01 | 0.674 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 1.388198e-01 | 0.858 | 0 | 0 |
| Signaling by activated point mutants of FGFR1 | R-HSA-1839122 | 2.415087e-01 | 0.617 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 2.415087e-01 | 0.617 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 2.415087e-01 | 0.617 | 0 | 0 |
| PP2A-mediated dephosphorylation of key metabolic factors | R-HSA-163767 | 3.120358e-01 | 0.506 | 0 | 0 |
| PTK6 Expression | R-HSA-8849473 | 3.120358e-01 | 0.506 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 3.120358e-01 | 0.506 | 0 | 0 |
| The NLRP1 inflammasome | R-HSA-844455 | 4.317534e-01 | 0.365 | 0 | 0 |
| Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | R-HSA-9673766 | 4.317534e-01 | 0.365 | 0 | 0 |
| Signaling by plasma membrane FGFR1 fusions | R-HSA-8853336 | 4.317534e-01 | 0.365 | 0 | 0 |
| Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | R-HSA-9944997 | 4.317534e-01 | 0.365 | 0 | 0 |
| Loss of Function of KMT2D in Kabuki Syndrome | R-HSA-9944971 | 4.317534e-01 | 0.365 | 0 | 0 |
| Invadopodia formation | R-HSA-8941237 | 4.317534e-01 | 0.365 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 2.715927e-01 | 0.566 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 2.715927e-01 | 0.566 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 2.715927e-01 | 0.566 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 2.715927e-01 | 0.566 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 2.715927e-01 | 0.566 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 2.715927e-01 | 0.566 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 1.933453e-01 | 0.714 | 0 | 0 |
| SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | R-HSA-77588 | 3.529738e-01 | 0.452 | 0 | 0 |
| FGFR1b ligand binding and activation | R-HSA-190370 | 3.529738e-01 | 0.452 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 3.529738e-01 | 0.452 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 3.529738e-01 | 0.452 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 3.529738e-01 | 0.452 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 1.713985e-01 | 0.766 | 0 | 0 |
| Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 2.638306e-01 | 0.579 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 2.638306e-01 | 0.579 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 2.539810e-01 | 0.595 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 2.886266e-01 | 0.540 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 2.886266e-01 | 0.540 | 0 | 0 |
| NFE2L2 regulating MDR associated enzymes | R-HSA-9818032 | 3.930240e-01 | 0.406 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 3.930240e-01 | 0.406 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 3.930240e-01 | 0.406 | 0 | 0 |
| MASTL Facilitates Mitotic Progression | R-HSA-2465910 | 3.930240e-01 | 0.406 | 0 | 0 |
| TNFR1-mediated ceramide production | R-HSA-5626978 | 4.925012e-01 | 0.308 | 0 | 0 |
| HCN channels | R-HSA-1296061 | 4.925012e-01 | 0.308 | 0 | 0 |
| Drug-mediated inhibition of CDK4/CDK6 activity | R-HSA-9754119 | 4.925012e-01 | 0.308 | 0 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 4.925012e-01 | 0.308 | 0 | 0 |
| Inhibition of TSC complex formation by PKB | R-HSA-165181 | 4.925012e-01 | 0.308 | 0 | 0 |
| Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | R-HSA-69200 | 4.925012e-01 | 0.308 | 0 | 0 |
| Defective CP causes aceruloplasminemia (ACERULOP) | R-HSA-5619060 | 4.925012e-01 | 0.308 | 0 | 0 |
| TGFBR1 KD Mutants in Cancer | R-HSA-3656532 | 4.925012e-01 | 0.308 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 2.437414e-01 | 0.613 | 0 | 0 |
| FRS-mediated FGFR1 signaling | R-HSA-5654693 | 2.751624e-01 | 0.560 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 2.751624e-01 | 0.560 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 1.585905e-01 | 0.800 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 3.631812e-01 | 0.440 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 3.631812e-01 | 0.440 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 3.631812e-01 | 0.440 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 3.631812e-01 | 0.440 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 2.812964e-01 | 0.551 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 3.389999e-01 | 0.470 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 3.389999e-01 | 0.470 | 0 | 0 |
| Formation of apoptosome | R-HSA-111458 | 4.319086e-01 | 0.365 | 0 | 0 |
| Regulation of the apoptosome activity | R-HSA-9627069 | 4.319086e-01 | 0.365 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 4.319086e-01 | 0.365 | 0 | 0 |
| Folding of actin by CCT/TriC | R-HSA-390450 | 4.319086e-01 | 0.365 | 0 | 0 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | R-HSA-5140745 | 4.319086e-01 | 0.365 | 0 | 0 |
| Activation of Ca-permeable Kainate Receptor | R-HSA-451308 | 4.319086e-01 | 0.365 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 3.184753e-01 | 0.497 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 3.184753e-01 | 0.497 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 3.005412e-01 | 0.522 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 3.005412e-01 | 0.522 | 0 | 0 |
| Differentiation of T cells | R-HSA-9945266 | 3.934897e-01 | 0.405 | 0 | 0 |
| Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | R-HSA-9942503 | 3.934897e-01 | 0.405 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 3.934897e-01 | 0.405 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 2.701369e-01 | 0.568 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 3.643378e-01 | 0.438 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 3.404438e-01 | 0.468 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 3.404438e-01 | 0.468 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 3.404438e-01 | 0.468 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 3.200199e-01 | 0.495 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 2.590449e-01 | 0.587 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 3.625161e-01 | 0.441 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | R-HSA-76071 | 3.896295e-01 | 0.409 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 3.896295e-01 | 0.409 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 4.234089e-01 | 0.373 | 0 | 0 |
| PTK6 Down-Regulation | R-HSA-8849472 | 5.467579e-01 | 0.262 | 0 | 0 |
| G2 Phase | R-HSA-68911 | 5.467579e-01 | 0.262 | 0 | 0 |
| NOSIP mediated eNOS trafficking | R-HSA-203754 | 5.467579e-01 | 0.262 | 0 | 0 |
| FGFR1c and Klotho ligand binding and activation | R-HSA-190374 | 5.467579e-01 | 0.262 | 0 | 0 |
| Defective binding of VWF variant to GPIb:IX:V | R-HSA-9846298 | 5.467579e-01 | 0.262 | 0 | 0 |
| Enhanced binding of GP1BA variant to VWF multimer:collagen | R-HSA-9845620 | 5.467579e-01 | 0.262 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 5.467579e-01 | 0.262 | 0 | 0 |
| Defective F9 activation | R-HSA-9673221 | 5.467579e-01 | 0.262 | 0 | 0 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | 5.467579e-01 | 0.262 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 3.846180e-01 | 0.415 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 3.846180e-01 | 0.415 | 0 | 0 |
| Interleukin receptor SHC signaling | R-HSA-912526 | 4.147749e-01 | 0.382 | 0 | 0 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 4.528031e-01 | 0.344 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 3.069379e-01 | 0.513 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 4.396824e-01 | 0.357 | 0 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 4.396824e-01 | 0.357 | 0 | 0 |
| SHC-mediated cascade:FGFR1 | R-HSA-5654688 | 4.396824e-01 | 0.357 | 0 | 0 |
| Cytochrome c-mediated apoptotic response | R-HSA-111461 | 5.054055e-01 | 0.296 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 5.054055e-01 | 0.296 | 0 | 0 |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | R-HSA-9824878 | 5.054055e-01 | 0.296 | 0 | 0 |
| ERKs are inactivated | R-HSA-202670 | 5.054055e-01 | 0.296 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 3.855208e-01 | 0.414 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 4.815564e-01 | 0.317 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 2.505674e-01 | 0.601 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 3.317246e-01 | 0.479 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 3.317246e-01 | 0.479 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 4.504202e-01 | 0.346 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 5.095716e-01 | 0.293 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 5.095716e-01 | 0.293 | 0 | 0 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | 5.397646e-01 | 0.268 | 0 | 0 |
| IRAK1 recruits IKK complex | R-HSA-937039 | 5.397646e-01 | 0.268 | 0 | 0 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | R-HSA-975144 | 5.397646e-01 | 0.268 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 5.397646e-01 | 0.268 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 4.777399e-01 | 0.321 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 4.777399e-01 | 0.321 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 4.932633e-01 | 0.307 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 4.969614e-01 | 0.304 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 5.367687e-01 | 0.270 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 5.367687e-01 | 0.270 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 5.367687e-01 | 0.270 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 5.367687e-01 | 0.270 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 5.354046e-01 | 0.271 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 4.888011e-01 | 0.311 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 5.346264e-01 | 0.272 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 5.365275e-01 | 0.270 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 2.410351e-01 | 0.618 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 5.142201e-01 | 0.289 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 1.755373e-01 | 0.756 | 1 | 1 |
| EPH-Ephrin signaling | R-HSA-2682334 | 1.864224e-01 | 0.730 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 2.255483e-01 | 0.647 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 2.332279e-01 | 0.632 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 3.934897e-01 | 0.405 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 5.367687e-01 | 0.270 | 0 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 1.559790e-01 | 0.807 | 0 | 0 |
| Transcriptional regulation of testis differentiation | R-HSA-9690406 | 4.234089e-01 | 0.373 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 1.400021e-01 | 0.854 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 3.529738e-01 | 0.452 | 0 | 0 |
| Synaptic adhesion-like molecules | R-HSA-8849932 | 2.638306e-01 | 0.579 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 3.769487e-01 | 0.424 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 5.025609e-01 | 0.299 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 2.012908e-01 | 0.696 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 2.012908e-01 | 0.696 | 0 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 3.896295e-01 | 0.409 | 0 | 0 |
| PTK6 Regulates Proteins Involved in RNA Processing | R-HSA-8849468 | 5.467579e-01 | 0.262 | 0 | 0 |
| Synthesis of PIPs at the late endosome membrane | R-HSA-1660517 | 4.528031e-01 | 0.344 | 0 | 0 |
| FGFR1 ligand binding and activation | R-HSA-190242 | 4.815564e-01 | 0.317 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 5.367687e-01 | 0.270 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 4.815564e-01 | 0.317 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 5.121918e-01 | 0.291 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 2.638306e-01 | 0.579 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 4.777399e-01 | 0.321 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 4.108927e-01 | 0.386 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 4.108927e-01 | 0.386 | 0 | 0 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 2.156659e-01 | 0.666 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 2.394657e-01 | 0.621 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 3.529738e-01 | 0.452 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 1.570908e-01 | 0.804 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 2.129878e-01 | 0.672 | 0 | 0 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | R-HSA-428542 | 3.930240e-01 | 0.406 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 4.319086e-01 | 0.365 | 0 | 0 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 3.934897e-01 | 0.405 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 3.200199e-01 | 0.495 | 0 | 0 |
| Synthesis of PIPs at the ER membrane | R-HSA-1483248 | 4.694193e-01 | 0.328 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 3.122622e-01 | 0.505 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 4.504202e-01 | 0.346 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 5.367687e-01 | 0.270 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 2.012908e-01 | 0.696 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 2.623436e-01 | 0.581 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 2.741975e-01 | 0.562 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 4.932633e-01 | 0.307 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 5.352294e-01 | 0.271 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 5.352294e-01 | 0.271 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 3.662433e-01 | 0.436 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 4.719808e-01 | 0.326 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 5.346264e-01 | 0.272 | 0 | 0 |
| G1 Phase | R-HSA-69236 | 5.346264e-01 | 0.272 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 2.448730e-01 | 0.611 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 2.448730e-01 | 0.611 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 2.448730e-01 | 0.611 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 2.448730e-01 | 0.611 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 1.482204e-01 | 0.829 | 0 | 0 |
| GLI proteins bind promoters of Hh responsive genes to promote transcription | R-HSA-5635851 | 2.290385e-01 | 0.640 | 0 | 0 |
| Role of second messengers in netrin-1 signaling | R-HSA-418890 | 2.715927e-01 | 0.566 | 0 | 0 |
| Adrenoceptors | R-HSA-390696 | 3.529738e-01 | 0.452 | 0 | 0 |
| Nef mediated downregulation of MHC class I complex cell surface expression | R-HSA-164940 | 3.529738e-01 | 0.452 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 2.078221e-01 | 0.682 | 0 | 0 |
| Regulation of gap junction activity | R-HSA-191650 | 4.925012e-01 | 0.308 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 2.584040e-01 | 0.588 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in BCR signaling | R-HSA-8939245 | 5.467579e-01 | 0.262 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 4.504202e-01 | 0.346 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 5.201009e-01 | 0.284 | 0 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 2.253735e-01 | 0.647 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 2.551960e-01 | 0.593 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 4.360931e-01 | 0.360 | 0 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 2.253735e-01 | 0.647 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 1.834318e-01 | 0.737 | 0 | 0 |
| Activated NTRK2 signals through FRS2 and FRS3 | R-HSA-9028731 | 5.397646e-01 | 0.268 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 5.205565e-01 | 0.284 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 4.738394e-01 | 0.324 | 0 | 0 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | R-HSA-6803207 | 3.934897e-01 | 0.405 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 4.387019e-01 | 0.358 | 0 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 3.385637e-01 | 0.470 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 4.017659e-01 | 0.396 | 1 | 0 |
| Glycogen breakdown (glycogenolysis) | R-HSA-70221 | 4.642691e-01 | 0.333 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 3.385637e-01 | 0.470 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 4.102981e-01 | 0.387 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 2.390441e-01 | 0.622 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 1.701925e-01 | 0.769 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 4.266970e-01 | 0.370 | 0 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 3.716335e-01 | 0.430 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 1.559790e-01 | 0.807 | 0 | 0 |
| Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 2.290385e-01 | 0.640 | 0 | 0 |
| CLEC7A (Dectin-1) induces NFAT activation | R-HSA-5607763 | 1.490382e-01 | 0.827 | 0 | 0 |
| Ca2+ activated K+ channels | R-HSA-1296052 | 3.120358e-01 | 0.506 | 0 | 0 |
| Disorders of Developmental Biology | R-HSA-9675151 | 2.156659e-01 | 0.666 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 2.394657e-01 | 0.621 | 0 | 0 |
| Neurotransmitter uptake and metabolism In glial cells | R-HSA-112313 | 3.529738e-01 | 0.452 | 0 | 0 |
| Astrocytic Glutamate-Glutamine Uptake And Metabolism | R-HSA-210455 | 3.529738e-01 | 0.452 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 2.812964e-01 | 0.551 | 0 | 0 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | 4.319086e-01 | 0.365 | 0 | 0 |
| Killing mechanisms | R-HSA-9664420 | 3.934897e-01 | 0.405 | 0 | 0 |
| WNT5:FZD7-mediated leishmania damping | R-HSA-9673324 | 3.934897e-01 | 0.405 | 0 | 0 |
| Formation of the posterior neural plate | R-HSA-9832991 | 4.694193e-01 | 0.328 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 3.168867e-01 | 0.499 | 0 | 0 |
| Modulation of host responses by IFN-stimulated genes | R-HSA-9909505 | 4.528031e-01 | 0.344 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 4.504202e-01 | 0.346 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 3.716335e-01 | 0.430 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 4.719808e-01 | 0.326 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 5.370223e-01 | 0.270 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 5.174512e-01 | 0.286 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 3.198489e-01 | 0.495 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 3.003465e-01 | 0.522 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 3.438412e-01 | 0.464 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 4.969614e-01 | 0.304 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 2.415087e-01 | 0.617 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 2.464010e-01 | 0.608 | 0 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 3.831472e-01 | 0.417 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 2.448730e-01 | 0.611 | 0 | 0 |
| SARS-CoV-1-mediated effects on programmed cell death | R-HSA-9692913 | 1.482204e-01 | 0.829 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 2.290385e-01 | 0.640 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 2.715927e-01 | 0.566 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 2.715927e-01 | 0.566 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 2.715927e-01 | 0.566 | 0 | 0 |
| Defective RIPK1-mediated regulated necrosis | R-HSA-9693928 | 4.319086e-01 | 0.365 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 4.319086e-01 | 0.365 | 0 | 0 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | R-HSA-164938 | 4.528031e-01 | 0.344 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 3.991484e-01 | 0.399 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 4.884608e-01 | 0.311 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 2.437414e-01 | 0.613 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 4.654660e-01 | 0.332 | 1 | 0 |
| Ion homeostasis | R-HSA-5578775 | 3.016058e-01 | 0.521 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 5.356190e-01 | 0.271 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 3.147026e-01 | 0.502 | 0 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 3.041299e-01 | 0.517 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 1.703136e-01 | 0.769 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 2.812964e-01 | 0.551 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 1.525451e-01 | 0.817 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 3.396752e-01 | 0.469 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 4.234089e-01 | 0.373 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 3.792929e-01 | 0.421 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 5.397646e-01 | 0.268 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 2.469379e-01 | 0.607 | 0 | 0 |
| Membrane Trafficking | R-HSA-199991 | 3.188691e-01 | 0.496 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 2.559145e-01 | 0.592 | 0 | 0 |
| Microbial modulation of RIPK1-mediated regulated necrosis | R-HSA-9686347 | 3.120358e-01 | 0.506 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 1.739944e-01 | 0.759 | 0 | 0 |
| PTK6 Activates STAT3 | R-HSA-8849474 | 5.467579e-01 | 0.262 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 5.095716e-01 | 0.293 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 4.096194e-01 | 0.388 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 3.293078e-01 | 0.482 | 1 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 3.280393e-01 | 0.484 | 0 | 0 |
| Signaling by FLT3 ITD and TKD mutants | R-HSA-9703648 | 4.396824e-01 | 0.357 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 1.434962e-01 | 0.843 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 1.694951e-01 | 0.771 | 0 | 0 |
| PLC beta mediated events | R-HSA-112043 | 2.584040e-01 | 0.588 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 3.029254e-01 | 0.519 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 3.013314e-01 | 0.521 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 2.813587e-01 | 0.551 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 3.523387e-01 | 0.453 | 0 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 4.514454e-01 | 0.345 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 2.044472e-01 | 0.689 | 1 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 3.523387e-01 | 0.453 | 0 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 3.523387e-01 | 0.453 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 1.794933e-01 | 0.746 | 0 | 0 |
| NFE2L2 regulating TCA cycle genes | R-HSA-9818025 | 1.880164e-01 | 0.726 | 0 | 0 |
| Interleukin-33 signaling | R-HSA-9014843 | 3.637386e-01 | 0.439 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 2.120344e-01 | 0.674 | 0 | 0 |
| Phase 4 - resting membrane potential | R-HSA-5576886 | 1.925688e-01 | 0.715 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 2.415087e-01 | 0.617 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 2.415087e-01 | 0.617 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 3.120358e-01 | 0.506 | 0 | 0 |
| Binding of TCF/LEF:CTNNB1 to target gene promoters | R-HSA-4411364 | 3.120358e-01 | 0.506 | 0 | 0 |
| Loss of MECP2 binding ability to 5mC-DNA | R-HSA-9022538 | 4.317534e-01 | 0.365 | 0 | 0 |
| MET interacts with TNS proteins | R-HSA-8875513 | 4.317534e-01 | 0.365 | 0 | 0 |
| Activation of BIM and translocation to mitochondria | R-HSA-111446 | 4.317534e-01 | 0.365 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 2.156659e-01 | 0.666 | 0 | 0 |
| Signaling by LTK | R-HSA-9842663 | 2.715927e-01 | 0.566 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 1.739944e-01 | 0.759 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 2.129878e-01 | 0.672 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 1.514098e-01 | 0.820 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 1.514098e-01 | 0.820 | 0 | 0 |
| Unwinding of DNA | R-HSA-176974 | 3.930240e-01 | 0.406 | 0 | 0 |
| Electric Transmission Across Gap Junctions | R-HSA-112303 | 4.925012e-01 | 0.308 | 0 | 0 |
| Transmission across Electrical Synapses | R-HSA-112307 | 4.925012e-01 | 0.308 | 0 | 0 |
| MECP2 regulates transcription of neuronal ligands | R-HSA-9022702 | 4.319086e-01 | 0.365 | 0 | 0 |
| Receptor-type tyrosine-protein phosphatases | R-HSA-388844 | 3.934897e-01 | 0.405 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 2.584040e-01 | 0.588 | 0 | 0 |
| Ionotropic activity of kainate receptors | R-HSA-451306 | 4.694193e-01 | 0.328 | 0 | 0 |
| Reelin signalling pathway | R-HSA-8866376 | 5.467579e-01 | 0.262 | 0 | 0 |
| Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 5.467579e-01 | 0.262 | 0 | 0 |
| PI3K Cascade | R-HSA-109704 | 3.352275e-01 | 0.475 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 2.923989e-01 | 0.534 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 4.396824e-01 | 0.357 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 4.387019e-01 | 0.358 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 4.387019e-01 | 0.358 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 4.108927e-01 | 0.386 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 4.932633e-01 | 0.307 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 3.951059e-01 | 0.403 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 1.686954e-01 | 0.773 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 2.065625e-01 | 0.685 | 0 | 0 |
| Cellular response to heat stress | R-HSA-3371556 | 3.605451e-01 | 0.443 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 4.654660e-01 | 0.332 | 0 | 0 |
| Caspase activation via extrinsic apoptotic signalling pathway | R-HSA-5357769 | 4.884608e-01 | 0.311 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 3.921185e-01 | 0.407 | 0 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 3.030209e-01 | 0.519 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 2.174237e-01 | 0.663 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 4.950284e-01 | 0.305 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 3.772570e-01 | 0.423 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 4.431586e-01 | 0.353 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 2.092742e-01 | 0.679 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 4.387019e-01 | 0.358 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 3.625161e-01 | 0.441 | 0 | 0 |
| MAP kinase activation | R-HSA-450294 | 3.792961e-01 | 0.421 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 1.514098e-01 | 0.820 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 1.570908e-01 | 0.804 | 1 | 1 |
| STAT5 activation downstream of FLT3 ITD mutants | R-HSA-9702518 | 4.234089e-01 | 0.373 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 4.642691e-01 | 0.333 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 3.259742e-01 | 0.487 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 3.022884e-01 | 0.520 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 3.016058e-01 | 0.521 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 3.377673e-01 | 0.471 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 1.635589e-01 | 0.786 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 5.357232e-01 | 0.271 | 0 | 0 |
| Interleukin-1 processing | R-HSA-448706 | 1.559790e-01 | 0.807 | 0 | 0 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | 3.120358e-01 | 0.506 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 3.529738e-01 | 0.452 | 0 | 0 |
| Activation of NOXA and translocation to mitochondria | R-HSA-111448 | 4.925012e-01 | 0.308 | 0 | 0 |
| Muscarinic acetylcholine receptors | R-HSA-390648 | 5.467579e-01 | 0.262 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 4.147749e-01 | 0.382 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 5.201009e-01 | 0.284 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 3.021003e-01 | 0.520 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 2.646545e-01 | 0.577 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 3.299396e-01 | 0.482 | 0 | 0 |
| Amine ligand-binding receptors | R-HSA-375280 | 5.346264e-01 | 0.272 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 1.561826e-01 | 0.806 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 4.319086e-01 | 0.365 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 4.031845e-01 | 0.394 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 1.426842e-01 | 0.846 | 0 | 0 |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | 3.020437e-01 | 0.520 | 0 | 0 |
| Caspase activation via Dependence Receptors in the absence of ligand | R-HSA-418889 | 3.930240e-01 | 0.406 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 5.397646e-01 | 0.268 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 4.119579e-01 | 0.385 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 2.812964e-01 | 0.551 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 2.616644e-01 | 0.582 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 3.799925e-01 | 0.420 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 2.584040e-01 | 0.588 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 4.899096e-01 | 0.310 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 3.983116e-01 | 0.400 | 0 | 0 |
| Uptake and function of anthrax toxins | R-HSA-5210891 | 4.528031e-01 | 0.344 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 2.349870e-01 | 0.629 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 4.465199e-01 | 0.350 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 2.875880e-01 | 0.541 | 0 | 0 |
| SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | R-HSA-111464 | 1.880164e-01 | 0.726 | 0 | 0 |
| DSCAM interactions | R-HSA-376172 | 3.637386e-01 | 0.439 | 0 | 0 |
| Tandem pore domain potassium channels | R-HSA-1296346 | 1.834318e-01 | 0.737 | 0 | 0 |
| Synthesis of PI | R-HSA-1483226 | 2.120344e-01 | 0.674 | 0 | 0 |
| Formation of the anterior neural plate | R-HSA-9823739 | 1.703136e-01 | 0.769 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 2.156659e-01 | 0.666 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9683610 | 3.020437e-01 | 0.520 | 0 | 0 |
| Sensory perception of sour taste | R-HSA-9729555 | 4.925012e-01 | 0.308 | 0 | 0 |
| Cross-presentation of particulate exogenous antigens (phagosomes) | R-HSA-1236973 | 4.319086e-01 | 0.365 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 4.319086e-01 | 0.365 | 0 | 0 |
| Interleukin-36 pathway | R-HSA-9014826 | 5.467579e-01 | 0.262 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 3.062206e-01 | 0.514 | 1 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 4.504202e-01 | 0.346 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 3.298423e-01 | 0.482 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 1.954455e-01 | 0.709 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 2.745492e-01 | 0.561 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 3.055396e-01 | 0.515 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 2.349870e-01 | 0.629 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 4.568768e-01 | 0.340 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 1.579998e-01 | 0.801 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 3.021003e-01 | 0.520 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 2.840379e-01 | 0.547 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 5.159348e-01 | 0.287 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 1.559790e-01 | 0.807 | 0 | 0 |
| RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | R-HSA-8877330 | 3.020437e-01 | 0.520 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 5.367687e-01 | 0.270 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 4.272212e-01 | 0.369 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 1.743834e-01 | 0.758 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 2.705707e-01 | 0.568 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 1.579998e-01 | 0.801 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 1.546794e-01 | 0.811 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 2.886266e-01 | 0.540 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 2.812964e-01 | 0.551 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 2.462427e-01 | 0.609 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 2.721747e-01 | 0.565 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 5.159348e-01 | 0.287 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 4.738394e-01 | 0.324 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 1.553243e-01 | 0.809 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 3.317246e-01 | 0.479 | 0 | 0 |
| NrCAM interactions | R-HSA-447038 | 1.880164e-01 | 0.726 | 0 | 0 |
| SMAC (DIABLO) binds to IAPs | R-HSA-111463 | 1.880164e-01 | 0.726 | 0 | 0 |
| Sodium-coupled phosphate cotransporters | R-HSA-427652 | 2.290385e-01 | 0.640 | 0 | 0 |
| MECP2 regulates transcription factors | R-HSA-9022707 | 3.120358e-01 | 0.506 | 0 | 0 |
| Passive transport by Aquaporins | R-HSA-432047 | 2.156659e-01 | 0.666 | 0 | 0 |
| Activation of the TFAP2 (AP-2) family of transcription factors | R-HSA-8866907 | 3.930240e-01 | 0.406 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 1.935620e-01 | 0.713 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 3.643378e-01 | 0.438 | 0 | 0 |
| RUNX2 regulates chondrocyte maturation | R-HSA-8941284 | 5.467579e-01 | 0.262 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 4.465199e-01 | 0.350 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 4.968405e-01 | 0.304 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 5.397646e-01 | 0.268 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 2.876402e-01 | 0.541 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 4.102981e-01 | 0.387 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 4.319086e-01 | 0.365 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 1.880164e-01 | 0.726 | 0 | 0 |
| SMAC, XIAP-regulated apoptotic response | R-HSA-111469 | 2.290385e-01 | 0.640 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 1.632606e-01 | 0.787 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 2.638306e-01 | 0.579 | 0 | 0 |
| Nephron development | R-HSA-9831926 | 2.638306e-01 | 0.579 | 0 | 0 |
| Interleukin-15 signaling | R-HSA-8983432 | 5.397646e-01 | 0.268 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 2.359879e-01 | 0.627 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 3.643378e-01 | 0.438 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 5.397646e-01 | 0.268 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 1.476482e-01 | 0.831 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 1.625012e-01 | 0.789 | 0 | 0 |
| HDL assembly | R-HSA-8963896 | 3.326399e-01 | 0.478 | 0 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 4.319086e-01 | 0.365 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 2.946512e-01 | 0.531 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 5.494555e-01 | 0.260 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 5.504627e-01 | 0.259 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 5.504627e-01 | 0.259 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 5.530057e-01 | 0.257 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 5.530057e-01 | 0.257 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 5.530057e-01 | 0.257 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 5.530057e-01 | 0.257 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 5.580497e-01 | 0.253 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 5.580497e-01 | 0.253 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 5.580497e-01 | 0.253 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 5.580497e-01 | 0.253 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 5.623065e-01 | 0.250 | 0 | 0 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 5.630834e-01 | 0.249 | 0 | 0 |
| ERK/MAPK targets | R-HSA-198753 | 5.630834e-01 | 0.249 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in apoptosis | R-HSA-9824594 | 5.630834e-01 | 0.249 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 5.630834e-01 | 0.249 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 5.649398e-01 | 0.248 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 5.707598e-01 | 0.244 | 0 | 0 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 5.724332e-01 | 0.242 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 5.724332e-01 | 0.242 | 0 | 0 |
| FGFR1c ligand binding and activation | R-HSA-190373 | 5.724332e-01 | 0.242 | 0 | 0 |
| Processing of SMDT1 | R-HSA-8949664 | 5.724332e-01 | 0.242 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 5.724332e-01 | 0.242 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | R-HSA-9029558 | 5.724332e-01 | 0.242 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 5.739077e-01 | 0.241 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 5.747285e-01 | 0.241 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 5.800852e-01 | 0.237 | 0 | 0 |
| DAP12 signaling | R-HSA-2424491 | 5.800852e-01 | 0.237 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 5.800852e-01 | 0.237 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 5.800852e-01 | 0.237 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 5.813402e-01 | 0.236 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 5.836504e-01 | 0.234 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 5.848136e-01 | 0.233 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 5.883551e-01 | 0.230 | 0 | 0 |
| FRS-mediated FGFR3 signaling | R-HSA-5654706 | 5.884659e-01 | 0.230 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 5.884659e-01 | 0.230 | 0 | 0 |
| Mitochondrial calcium ion transport | R-HSA-8949215 | 5.884659e-01 | 0.230 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 5.887195e-01 | 0.230 | 0 | 0 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 5.887195e-01 | 0.230 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 5.887195e-01 | 0.230 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 5.891571e-01 | 0.230 | 0 | 0 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 5.952169e-01 | 0.225 | 0 | 0 |
| Nef Mediated CD8 Down-regulation | R-HSA-182218 | 5.952169e-01 | 0.225 | 0 | 0 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | 5.952169e-01 | 0.225 | 0 | 0 |
| PKB-mediated events | R-HSA-109703 | 5.952169e-01 | 0.225 | 0 | 0 |
| PDE3B signalling | R-HSA-165160 | 5.952169e-01 | 0.225 | 0 | 0 |
| Defective CSF2RA causes SMDP4 | R-HSA-5688890 | 5.952169e-01 | 0.225 | 0 | 0 |
| Loss of MECP2 binding ability to the NCoR/SMRT complex | R-HSA-9022537 | 5.952169e-01 | 0.225 | 0 | 0 |
| Defective CSF2RB causes SMDP5 | R-HSA-5688849 | 5.952169e-01 | 0.225 | 0 | 0 |
| NGF-independant TRKA activation | R-HSA-187024 | 5.952169e-01 | 0.225 | 0 | 0 |
| Pentose phosphate pathway disease | R-HSA-6791465 | 5.952169e-01 | 0.225 | 0 | 0 |
| Synthesis of PS | R-HSA-1483101 | 5.952169e-01 | 0.225 | 0 | 0 |
| Formation of the Editosome | R-HSA-75094 | 5.952169e-01 | 0.225 | 0 | 0 |
| Phosphorylation of Emi1 | R-HSA-176417 | 5.952169e-01 | 0.225 | 0 | 0 |
| Release of Hh-Np from the secreting cell | R-HSA-5362798 | 5.952169e-01 | 0.225 | 0 | 0 |
| Defects of platelet adhesion to exposed collagen | R-HSA-9823587 | 5.952169e-01 | 0.225 | 0 | 0 |
| Signalling to p38 via RIT and RIN | R-HSA-187706 | 5.952169e-01 | 0.225 | 0 | 0 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | 5.952169e-01 | 0.225 | 0 | 0 |
| Acetylcholine inhibits contraction of outer hair cells | R-HSA-9667769 | 5.952169e-01 | 0.225 | 0 | 0 |
| Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | R-HSA-2660825 | 5.952169e-01 | 0.225 | 0 | 0 |
| Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | R-HSA-2660826 | 5.952169e-01 | 0.225 | 0 | 0 |
| SLC15A4:TASL-dependent IRF5 activation | R-HSA-9860276 | 5.952169e-01 | 0.225 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 5.978277e-01 | 0.223 | 0 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 6.014764e-01 | 0.221 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 6.020057e-01 | 0.220 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 6.033800e-01 | 0.219 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 6.033800e-01 | 0.219 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 6.033800e-01 | 0.219 | 0 | 0 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | R-HSA-5684264 | 6.033800e-01 | 0.219 | 0 | 0 |
| Signaling by FGFR4 in disease | R-HSA-5655291 | 6.033800e-01 | 0.219 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 6.033800e-01 | 0.219 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 6.046859e-01 | 0.218 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 6.075232e-01 | 0.216 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 6.075232e-01 | 0.216 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 6.119165e-01 | 0.213 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 6.127708e-01 | 0.213 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 6.127708e-01 | 0.213 | 0 | 0 |
| FRS-mediated FGFR4 signaling | R-HSA-5654712 | 6.128794e-01 | 0.213 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 6.128794e-01 | 0.213 | 0 | 0 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | R-HSA-6803205 | 6.128794e-01 | 0.213 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 6.128794e-01 | 0.213 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 6.146628e-01 | 0.211 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 6.166002e-01 | 0.210 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 6.178953e-01 | 0.209 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 6.188436e-01 | 0.208 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 6.239059e-01 | 0.205 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 6.321270e-01 | 0.199 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 6.325997e-01 | 0.199 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 6.325997e-01 | 0.199 | 0 | 0 |
| Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | R-HSA-9673767 | 6.325997e-01 | 0.199 | 0 | 0 |
| Signaling by PDGFRA extracellular domain mutants | R-HSA-9673770 | 6.325997e-01 | 0.199 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 6.325997e-01 | 0.199 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 6.325997e-01 | 0.199 | 0 | 0 |
| RNA Polymerase III Chain Elongation | R-HSA-73780 | 6.325997e-01 | 0.199 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 6.325997e-01 | 0.199 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 6.325997e-01 | 0.199 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 6.325997e-01 | 0.199 | 0 | 0 |
| Formation of the ureteric bud | R-HSA-9830674 | 6.362986e-01 | 0.196 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 6.362986e-01 | 0.196 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 6.384974e-01 | 0.195 | 0 | 0 |
| STAT5 Activation | R-HSA-9645135 | 6.384974e-01 | 0.195 | 0 | 0 |
| Autointegration results in viral DNA circles | R-HSA-177539 | 6.384974e-01 | 0.195 | 0 | 0 |
| RAS signaling downstream of NF1 loss-of-function variants | R-HSA-6802953 | 6.384974e-01 | 0.195 | 0 | 0 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | 6.384974e-01 | 0.195 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 6.384974e-01 | 0.195 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in WNT signaling | R-HSA-8939256 | 6.384974e-01 | 0.195 | 0 | 0 |
| Hydrolysis of LPE | R-HSA-1483152 | 6.384974e-01 | 0.195 | 0 | 0 |
| Integration of viral DNA into host genomic DNA | R-HSA-175567 | 6.384974e-01 | 0.195 | 0 | 0 |
| NADPH regeneration | R-HSA-389542 | 6.384974e-01 | 0.195 | 0 | 0 |
| Lipid particle organization | R-HSA-8964572 | 6.384974e-01 | 0.195 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 6.404291e-01 | 0.194 | 1 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 6.422198e-01 | 0.192 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 6.473164e-01 | 0.189 | 0 | 0 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | R-HSA-9615017 | 6.487490e-01 | 0.188 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 6.487490e-01 | 0.188 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 6.551261e-01 | 0.184 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 6.553735e-01 | 0.184 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 6.553735e-01 | 0.184 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 6.555339e-01 | 0.183 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 6.561277e-01 | 0.183 | 0 | 0 |
| TNFs bind their physiological receptors | R-HSA-5669034 | 6.587085e-01 | 0.181 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 6.587085e-01 | 0.181 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 6.597572e-01 | 0.181 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 6.601078e-01 | 0.180 | 0 | 0 |
| Caspase activation via Death Receptors in the presence of ligand | R-HSA-140534 | 6.601078e-01 | 0.180 | 0 | 0 |
| Regulation of BACH1 activity | R-HSA-9708530 | 6.601078e-01 | 0.180 | 0 | 0 |
| Serotonin and melatonin biosynthesis | R-HSA-209931 | 6.601078e-01 | 0.180 | 0 | 0 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | R-HSA-210744 | 6.601078e-01 | 0.180 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 6.601078e-01 | 0.180 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 6.659229e-01 | 0.177 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 6.750563e-01 | 0.171 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 6.762259e-01 | 0.170 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 6.762259e-01 | 0.170 | 0 | 0 |
| RUNX1 regulates estrogen receptor mediated transcription | R-HSA-8931987 | 6.771525e-01 | 0.169 | 0 | 0 |
| Defective HLCS causes multiple carboxylase deficiency | R-HSA-3371599 | 6.771525e-01 | 0.169 | 0 | 0 |
| NOSTRIN mediated eNOS trafficking | R-HSA-203641 | 6.771525e-01 | 0.169 | 0 | 0 |
| Netrin mediated repulsion signals | R-HSA-418886 | 6.771525e-01 | 0.169 | 0 | 0 |
| IFNG signaling activates MAPKs | R-HSA-9732724 | 6.771525e-01 | 0.169 | 0 | 0 |
| Disinhibition of SNARE formation | R-HSA-114516 | 6.771525e-01 | 0.169 | 0 | 0 |
| SLBP independent Processing of Histone Pre-mRNAs | R-HSA-111367 | 6.771525e-01 | 0.169 | 0 | 0 |
| mRNA Editing: C to U Conversion | R-HSA-72200 | 6.771525e-01 | 0.169 | 0 | 0 |
| Nef Mediated CD4 Down-regulation | R-HSA-167590 | 6.771525e-01 | 0.169 | 0 | 0 |
| Activated NTRK2 signals through CDK5 | R-HSA-9032845 | 6.771525e-01 | 0.169 | 0 | 0 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | 6.771525e-01 | 0.169 | 0 | 0 |
| Activation of PUMA and translocation to mitochondria | R-HSA-139915 | 6.771525e-01 | 0.169 | 0 | 0 |
| VLDL clearance | R-HSA-8964046 | 6.771525e-01 | 0.169 | 0 | 0 |
| Insulin effects increased synthesis of Xylulose-5-Phosphate | R-HSA-163754 | 6.771525e-01 | 0.169 | 0 | 0 |
| Activation of TRKA receptors | R-HSA-187015 | 6.771525e-01 | 0.169 | 0 | 0 |
| Phase 3 - rapid repolarisation | R-HSA-5576890 | 6.771525e-01 | 0.169 | 0 | 0 |
| Glycoprotein hormones | R-HSA-209822 | 6.771525e-01 | 0.169 | 0 | 0 |
| CHL1 interactions | R-HSA-447041 | 6.771525e-01 | 0.169 | 0 | 0 |
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 6.771525e-01 | 0.169 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 6.801032e-01 | 0.167 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 6.801032e-01 | 0.167 | 0 | 0 |
| Formation of the nephric duct | R-HSA-9830364 | 6.801032e-01 | 0.167 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 6.801278e-01 | 0.167 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 6.801278e-01 | 0.167 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 6.801278e-01 | 0.167 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 6.801278e-01 | 0.167 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 6.825384e-01 | 0.166 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 6.859363e-01 | 0.164 | 0 | 0 |
| Phase 2 - plateau phase | R-HSA-5576893 | 6.859363e-01 | 0.164 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 6.859363e-01 | 0.164 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 6.859363e-01 | 0.164 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 6.859363e-01 | 0.164 | 0 | 0 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 6.859363e-01 | 0.164 | 0 | 0 |
| Synthesis of PG | R-HSA-1483148 | 6.859363e-01 | 0.164 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 6.861274e-01 | 0.164 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 6.870963e-01 | 0.163 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 6.901631e-01 | 0.161 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 6.921046e-01 | 0.160 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 6.979944e-01 | 0.156 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 6.979944e-01 | 0.156 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 7.004847e-01 | 0.155 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 7.004847e-01 | 0.155 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 7.007280e-01 | 0.154 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 7.007280e-01 | 0.154 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 7.037078e-01 | 0.153 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 7.071624e-01 | 0.150 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 7.101297e-01 | 0.149 | 0 | 0 |
| Myoclonic epilepsy of Lafora | R-HSA-3785653 | 7.116763e-01 | 0.148 | 0 | 0 |
| Axonal growth inhibition (RHOA activation) | R-HSA-193634 | 7.116763e-01 | 0.148 | 0 | 0 |
| Regulation by c-FLIP | R-HSA-3371378 | 7.116763e-01 | 0.148 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | R-HSA-8939246 | 7.116763e-01 | 0.148 | 0 | 0 |
| Dimerization of procaspase-8 | R-HSA-69416 | 7.116763e-01 | 0.148 | 0 | 0 |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | R-HSA-9828211 | 7.116763e-01 | 0.148 | 0 | 0 |
| Alpha-defensins | R-HSA-1462054 | 7.116763e-01 | 0.148 | 0 | 0 |
| Negative regulation of activity of TFAP2 (AP-2) family transcription factors | R-HSA-8866904 | 7.116763e-01 | 0.148 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 7.140686e-01 | 0.146 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 7.140686e-01 | 0.146 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 7.140686e-01 | 0.146 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 7.194451e-01 | 0.143 | 0 | 0 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 7.198616e-01 | 0.143 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 7.198616e-01 | 0.143 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 7.198616e-01 | 0.143 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 7.198616e-01 | 0.143 | 0 | 0 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 7.198616e-01 | 0.143 | 0 | 0 |
| Influenza Infection | R-HSA-168255 | 7.225251e-01 | 0.141 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 7.226713e-01 | 0.141 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 7.286368e-01 | 0.137 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 7.286368e-01 | 0.137 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 7.286368e-01 | 0.137 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 7.286368e-01 | 0.137 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 7.289775e-01 | 0.137 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 7.289775e-01 | 0.137 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 7.289775e-01 | 0.137 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 7.289775e-01 | 0.137 | 0 | 0 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 7.315445e-01 | 0.136 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 7.327424e-01 | 0.135 | 0 | 0 |
| Apoptotic factor-mediated response | R-HSA-111471 | 7.327424e-01 | 0.135 | 0 | 0 |
| Tie2 Signaling | R-HSA-210993 | 7.327424e-01 | 0.135 | 0 | 0 |
| Vitamin D (calciferol) metabolism | R-HSA-196791 | 7.327424e-01 | 0.135 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9679504 | 7.327424e-01 | 0.135 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 7.360659e-01 | 0.133 | 0 | 0 |
| FRS-mediated FGFR2 signaling | R-HSA-5654700 | 7.382485e-01 | 0.132 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 7.382485e-01 | 0.132 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 7.382485e-01 | 0.132 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 7.382485e-01 | 0.132 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 7.382485e-01 | 0.132 | 0 | 0 |
| Interleukin-21 signaling | R-HSA-9020958 | 7.425101e-01 | 0.129 | 0 | 0 |
| CASP8 activity is inhibited | R-HSA-5218900 | 7.425101e-01 | 0.129 | 0 | 0 |
| Defects in biotin (Btn) metabolism | R-HSA-3323169 | 7.425101e-01 | 0.129 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 7.425101e-01 | 0.129 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex | R-HSA-937042 | 7.425101e-01 | 0.129 | 0 | 0 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | R-HSA-9013700 | 7.425101e-01 | 0.129 | 0 | 0 |
| p75NTR regulates axonogenesis | R-HSA-193697 | 7.425101e-01 | 0.129 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 7.425101e-01 | 0.129 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 7.425101e-01 | 0.129 | 0 | 0 |
| AMPK inhibits chREBP transcriptional activation activity | R-HSA-163680 | 7.425101e-01 | 0.129 | 0 | 0 |
| mRNA Editing | R-HSA-75072 | 7.425101e-01 | 0.129 | 0 | 0 |
| Regulation of NPAS4 gene transcription | R-HSA-9768777 | 7.425101e-01 | 0.129 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 7.425101e-01 | 0.129 | 0 | 0 |
| Zinc influx into cells by the SLC39 gene family | R-HSA-442380 | 7.425101e-01 | 0.129 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 7.425101e-01 | 0.129 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 7.425101e-01 | 0.129 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 7.433160e-01 | 0.129 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 7.437414e-01 | 0.129 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 7.446063e-01 | 0.128 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 7.466738e-01 | 0.127 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 7.466738e-01 | 0.127 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 7.472361e-01 | 0.127 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 7.501204e-01 | 0.125 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 7.538356e-01 | 0.123 | 0 | 0 |
| Specification of the neural plate border | R-HSA-9834899 | 7.538356e-01 | 0.123 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 7.538356e-01 | 0.123 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 7.538356e-01 | 0.123 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 7.538924e-01 | 0.123 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 7.546615e-01 | 0.122 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 7.546615e-01 | 0.122 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 7.556648e-01 | 0.122 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 7.556648e-01 | 0.122 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 7.567533e-01 | 0.121 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 7.570873e-01 | 0.121 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 7.622160e-01 | 0.118 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 7.650793e-01 | 0.116 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 7.665521e-01 | 0.115 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 7.665521e-01 | 0.115 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 7.669701e-01 | 0.115 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 7.669701e-01 | 0.115 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 7.679815e-01 | 0.115 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 7.700480e-01 | 0.113 | 0 | 0 |
| TET1,2,3 and TDG demethylate DNA | R-HSA-5221030 | 7.700480e-01 | 0.113 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 7.700480e-01 | 0.113 | 0 | 0 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | R-HSA-2151209 | 7.700480e-01 | 0.113 | 0 | 0 |
| Formation of intermediate mesoderm | R-HSA-9761174 | 7.700480e-01 | 0.113 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 7.700480e-01 | 0.113 | 0 | 0 |
| Defective factor IX causes hemophilia B | R-HSA-9668250 | 7.700480e-01 | 0.113 | 0 | 0 |
| Peptide hormone biosynthesis | R-HSA-209952 | 7.700480e-01 | 0.113 | 0 | 0 |
| Metal sequestration by antimicrobial proteins | R-HSA-6799990 | 7.700480e-01 | 0.113 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 7.702966e-01 | 0.113 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 7.721338e-01 | 0.112 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 7.721338e-01 | 0.112 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 7.721338e-01 | 0.112 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 7.721338e-01 | 0.112 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 7.734758e-01 | 0.112 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 7.734758e-01 | 0.112 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 7.734758e-01 | 0.112 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 7.734758e-01 | 0.112 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 7.756119e-01 | 0.110 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 7.764957e-01 | 0.110 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 7.764957e-01 | 0.110 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 7.764957e-01 | 0.110 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 7.765781e-01 | 0.110 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 7.774532e-01 | 0.109 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 7.782998e-01 | 0.109 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 7.829509e-01 | 0.106 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 7.829509e-01 | 0.106 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 7.853092e-01 | 0.105 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 7.857729e-01 | 0.105 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 7.857965e-01 | 0.105 | 0 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 7.859095e-01 | 0.105 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 7.873251e-01 | 0.104 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 7.876823e-01 | 0.104 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 7.876823e-01 | 0.104 | 0 | 0 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 7.876823e-01 | 0.104 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 7.876823e-01 | 0.104 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 7.879966e-01 | 0.103 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 7.900890e-01 | 0.102 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 7.900890e-01 | 0.102 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 7.901981e-01 | 0.102 | 0 | 0 |
| SHC-mediated cascade:FGFR3 | R-HSA-5654704 | 7.917323e-01 | 0.101 | 0 | 0 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 7.917323e-01 | 0.101 | 0 | 0 |
| Signalling to RAS | R-HSA-167044 | 7.917323e-01 | 0.101 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 7.930693e-01 | 0.101 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 7.946423e-01 | 0.100 | 0 | 0 |
| LGI-ADAM interactions | R-HSA-5682910 | 7.946423e-01 | 0.100 | 0 | 0 |
| FGFR2b ligand binding and activation | R-HSA-190377 | 7.946423e-01 | 0.100 | 0 | 0 |
| Interleukin-2 signaling | R-HSA-9020558 | 7.946423e-01 | 0.100 | 0 | 0 |
| Activated NTRK3 signals through RAS | R-HSA-9034864 | 7.946423e-01 | 0.100 | 0 | 0 |
| FGFRL1 modulation of FGFR1 signaling | R-HSA-5658623 | 7.946423e-01 | 0.100 | 0 | 0 |
| RHOBTB3 ATPase cycle | R-HSA-9706019 | 7.946423e-01 | 0.100 | 0 | 0 |
| Transport of RCbl within the body | R-HSA-9758890 | 7.946423e-01 | 0.100 | 0 | 0 |
| CD163 mediating an anti-inflammatory response | R-HSA-9662834 | 7.946423e-01 | 0.100 | 0 | 0 |
| Alpha-protein kinase 1 signaling pathway | R-HSA-9645460 | 7.946423e-01 | 0.100 | 0 | 0 |
| SARS-CoV-2 modulates autophagy | R-HSA-9754560 | 7.946423e-01 | 0.100 | 0 | 0 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | 7.946423e-01 | 0.100 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 7.969108e-01 | 0.099 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 7.986550e-01 | 0.098 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 8.011285e-01 | 0.096 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 8.023395e-01 | 0.096 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 8.023395e-01 | 0.096 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 8.023395e-01 | 0.096 | 0 | 0 |
| Inwardly rectifying K+ channels | R-HSA-1296065 | 8.023395e-01 | 0.096 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 8.030115e-01 | 0.095 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 8.030115e-01 | 0.095 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 8.030115e-01 | 0.095 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 8.030115e-01 | 0.095 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 8.051332e-01 | 0.094 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 8.066298e-01 | 0.093 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 8.066298e-01 | 0.093 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 8.066298e-01 | 0.093 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 8.076470e-01 | 0.093 | 0 | 0 |
| SHC-mediated cascade:FGFR4 | R-HSA-5654719 | 8.086764e-01 | 0.092 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 8.086764e-01 | 0.092 | 0 | 0 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | 8.086764e-01 | 0.092 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 8.113627e-01 | 0.091 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 8.113627e-01 | 0.091 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 8.124282e-01 | 0.090 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 8.142925e-01 | 0.089 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 8.161369e-01 | 0.088 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 8.161369e-01 | 0.088 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 8.166075e-01 | 0.088 | 0 | 0 |
| Activated NTRK2 signals through RAS | R-HSA-9026519 | 8.166075e-01 | 0.088 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 8.166075e-01 | 0.088 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 8.166075e-01 | 0.088 | 0 | 0 |
| Sensing of DNA Double Strand Breaks | R-HSA-5693548 | 8.166075e-01 | 0.088 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | R-HSA-9623433 | 8.166075e-01 | 0.088 | 0 | 0 |
| Sodium/Calcium exchangers | R-HSA-425561 | 8.166075e-01 | 0.088 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 8.176758e-01 | 0.087 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 8.176758e-01 | 0.087 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 8.226694e-01 | 0.085 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 8.243800e-01 | 0.084 | 0 | 0 |
| LDL clearance | R-HSA-8964038 | 8.243800e-01 | 0.084 | 0 | 0 |
| RAF-independent MAPK1/3 activation | R-HSA-112409 | 8.243800e-01 | 0.084 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9694676 | 8.243800e-01 | 0.084 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 8.264415e-01 | 0.083 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 8.269152e-01 | 0.083 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 8.269152e-01 | 0.083 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 8.273699e-01 | 0.082 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 8.282087e-01 | 0.082 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 8.287211e-01 | 0.082 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 8.291071e-01 | 0.081 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 8.291071e-01 | 0.081 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 8.291071e-01 | 0.081 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 8.328859e-01 | 0.079 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 8.349743e-01 | 0.078 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 8.362243e-01 | 0.078 | 0 | 0 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | R-HSA-3656253 | 8.362243e-01 | 0.078 | 0 | 0 |
| Defective EXT2 causes exostoses 2 | R-HSA-3656237 | 8.362243e-01 | 0.078 | 0 | 0 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 8.362243e-01 | 0.078 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 8.362243e-01 | 0.078 | 0 | 0 |
| Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | R-HSA-9931530 | 8.362243e-01 | 0.078 | 0 | 0 |
| MET activates RAS signaling | R-HSA-8851805 | 8.362243e-01 | 0.078 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | R-HSA-2691232 | 8.362243e-01 | 0.078 | 0 | 0 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | R-HSA-2691230 | 8.362243e-01 | 0.078 | 0 | 0 |
| VLDLR internalisation and degradation | R-HSA-8866427 | 8.362243e-01 | 0.078 | 0 | 0 |
| SHC-related events triggered by IGF1R | R-HSA-2428933 | 8.362243e-01 | 0.078 | 0 | 0 |
| Diseases associated with surfactant metabolism | R-HSA-5687613 | 8.362243e-01 | 0.078 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 8.362243e-01 | 0.078 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 8.362243e-01 | 0.078 | 0 | 0 |
| Advanced glycosylation endproduct receptor signaling | R-HSA-879415 | 8.362243e-01 | 0.078 | 0 | 0 |
| Erythrocytes take up oxygen and release carbon dioxide | R-HSA-1247673 | 8.362243e-01 | 0.078 | 0 | 0 |
| Estrogen biosynthesis | R-HSA-193144 | 8.362243e-01 | 0.078 | 0 | 0 |
| Reversal of alkylation damage by DNA dioxygenases | R-HSA-73943 | 8.362243e-01 | 0.078 | 0 | 0 |
| Surfactant metabolism | R-HSA-5683826 | 8.379348e-01 | 0.077 | 0 | 0 |
| DAP12 interactions | R-HSA-2172127 | 8.379348e-01 | 0.077 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 8.382417e-01 | 0.077 | 0 | 0 |
| Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 8.389145e-01 | 0.076 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 8.389145e-01 | 0.076 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 8.389145e-01 | 0.076 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 8.397909e-01 | 0.076 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 8.412842e-01 | 0.075 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 8.412842e-01 | 0.075 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 8.412842e-01 | 0.075 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 8.437612e-01 | 0.074 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 8.445483e-01 | 0.073 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 8.456194e-01 | 0.073 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 8.483601e-01 | 0.071 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 8.512694e-01 | 0.070 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 8.518867e-01 | 0.070 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 8.523502e-01 | 0.069 | 0 | 0 |
| Assembly of active LPL and LIPC lipase complexes | R-HSA-8963889 | 8.523502e-01 | 0.069 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 8.527026e-01 | 0.069 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 8.537439e-01 | 0.069 | 0 | 0 |
| Adenylate cyclase activating pathway | R-HSA-170660 | 8.537439e-01 | 0.069 | 0 | 0 |
| FGFR2c ligand binding and activation | R-HSA-190375 | 8.537439e-01 | 0.069 | 0 | 0 |
| Golgi Cisternae Pericentriolar Stack Reorganization | R-HSA-162658 | 8.537439e-01 | 0.069 | 0 | 0 |
| Membrane binding and targetting of GAG proteins | R-HSA-174490 | 8.537439e-01 | 0.069 | 0 | 0 |
| FGFR4 ligand binding and activation | R-HSA-190322 | 8.537439e-01 | 0.069 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 8.537439e-01 | 0.069 | 0 | 0 |
| Signaling by activated point mutants of FGFR3 | R-HSA-1839130 | 8.537439e-01 | 0.069 | 0 | 0 |
| Chylomicron remodeling | R-HSA-8963901 | 8.537439e-01 | 0.069 | 0 | 0 |
| Mtb iron assimilation by chelation | R-HSA-1222449 | 8.537439e-01 | 0.069 | 0 | 0 |
| Reversible hydration of carbon dioxide | R-HSA-1475029 | 8.537439e-01 | 0.069 | 0 | 0 |
| FGFR3 mutant receptor activation | R-HSA-2033514 | 8.537439e-01 | 0.069 | 0 | 0 |
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | R-HSA-5676594 | 8.537439e-01 | 0.069 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 8.537439e-01 | 0.069 | 0 | 0 |
| Acyl chain remodeling of DAG and TAG | R-HSA-1482883 | 8.537439e-01 | 0.069 | 0 | 0 |
| Platelet Adhesion to exposed collagen | R-HSA-75892 | 8.537439e-01 | 0.069 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 8.568641e-01 | 0.067 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 8.628231e-01 | 0.064 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 8.633970e-01 | 0.064 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 8.633970e-01 | 0.064 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 8.633970e-01 | 0.064 | 0 | 0 |
| Glycosphingolipid transport | R-HSA-9845576 | 8.633970e-01 | 0.064 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 8.633970e-01 | 0.064 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 8.633970e-01 | 0.064 | 0 | 0 |
| Triglyceride catabolism | R-HSA-163560 | 8.633970e-01 | 0.064 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 8.633970e-01 | 0.064 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 8.647559e-01 | 0.063 | 0 | 0 |
| Activation of G protein gated Potassium channels | R-HSA-1296041 | 8.647559e-01 | 0.063 | 0 | 0 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | R-HSA-997272 | 8.647559e-01 | 0.063 | 0 | 0 |
| G protein gated Potassium channels | R-HSA-1296059 | 8.647559e-01 | 0.063 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 8.647559e-01 | 0.063 | 0 | 0 |
| Synthesis of PIPs at the early endosome membrane | R-HSA-1660516 | 8.647559e-01 | 0.063 | 0 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 8.654829e-01 | 0.063 | 0 | 0 |
| Removal of the Flap Intermediate | R-HSA-69166 | 8.693902e-01 | 0.061 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR3 | R-HSA-5654227 | 8.693902e-01 | 0.061 | 0 | 0 |
| Retrograde neurotrophin signalling | R-HSA-177504 | 8.693902e-01 | 0.061 | 0 | 0 |
| TP53 Regulates Transcription of Death Receptors and Ligands | R-HSA-6803211 | 8.693902e-01 | 0.061 | 0 | 0 |
| Regulation of CDH1 mRNA translation by microRNAs | R-HSA-9764562 | 8.693902e-01 | 0.061 | 0 | 0 |
| FGFR3c ligand binding and activation | R-HSA-190372 | 8.693902e-01 | 0.061 | 0 | 0 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | R-HSA-174495 | 8.693902e-01 | 0.061 | 0 | 0 |
| cGMP effects | R-HSA-418457 | 8.693902e-01 | 0.061 | 0 | 0 |
| Hydrolysis of LPC | R-HSA-1483115 | 8.693902e-01 | 0.061 | 0 | 0 |
| Respiratory syncytial virus genome transcription | R-HSA-9828642 | 8.693902e-01 | 0.061 | 0 | 0 |
| Malate-aspartate shuttle | R-HSA-9856872 | 8.693902e-01 | 0.061 | 0 | 0 |
| P2Y receptors | R-HSA-417957 | 8.693902e-01 | 0.061 | 0 | 0 |
| Zinc transporters | R-HSA-435354 | 8.693902e-01 | 0.061 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 8.728085e-01 | 0.059 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 8.734022e-01 | 0.059 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 8.761982e-01 | 0.057 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 8.761982e-01 | 0.057 | 0 | 0 |
| Synthesis of IP2, IP, and Ins in the cytosol | R-HSA-1855183 | 8.761982e-01 | 0.057 | 0 | 0 |
| Sphingolipid catabolism | R-HSA-9845614 | 8.761982e-01 | 0.057 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 8.761982e-01 | 0.057 | 0 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 8.802405e-01 | 0.055 | 0 | 0 |
| GABA receptor activation | R-HSA-977443 | 8.814120e-01 | 0.055 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 8.824259e-01 | 0.054 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 8.827526e-01 | 0.054 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 8.827526e-01 | 0.054 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 8.828446e-01 | 0.054 | 0 | 0 |
| Adenylate cyclase inhibitory pathway | R-HSA-170670 | 8.833636e-01 | 0.054 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR4 | R-HSA-5654228 | 8.833636e-01 | 0.054 | 0 | 0 |
| G beta:gamma signalling through BTK | R-HSA-8964315 | 8.833636e-01 | 0.054 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 8.833636e-01 | 0.054 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 8.833636e-01 | 0.054 | 0 | 0 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 8.833636e-01 | 0.054 | 0 | 0 |
| Signaling by Activin | R-HSA-1502540 | 8.833636e-01 | 0.054 | 0 | 0 |
| p38MAPK events | R-HSA-171007 | 8.833636e-01 | 0.054 | 0 | 0 |
| Lysosphingolipid and LPA receptors | R-HSA-419408 | 8.833636e-01 | 0.054 | 0 | 0 |
| Biotin transport and metabolism | R-HSA-196780 | 8.833636e-01 | 0.054 | 0 | 0 |
| FGFR3 ligand binding and activation | R-HSA-190239 | 8.833636e-01 | 0.054 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 8.833636e-01 | 0.054 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 8.833636e-01 | 0.054 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 8.833636e-01 | 0.054 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 8.833636e-01 | 0.054 | 0 | 0 |
| DNA Damage Reversal | R-HSA-73942 | 8.833636e-01 | 0.054 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 8.833723e-01 | 0.054 | 1 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 8.845489e-01 | 0.053 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 8.866704e-01 | 0.052 | 0 | 0 |
| SHC-mediated cascade:FGFR2 | R-HSA-5654699 | 8.867411e-01 | 0.052 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 8.867411e-01 | 0.052 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 8.867411e-01 | 0.052 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 8.874231e-01 | 0.052 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 8.874231e-01 | 0.052 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 8.875124e-01 | 0.052 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 8.891997e-01 | 0.051 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 8.914822e-01 | 0.050 | 0 | 0 |
| Defective GALNT3 causes HFTC | R-HSA-5083625 | 8.958427e-01 | 0.048 | 0 | 0 |
| Defective GALNT12 causes CRCS1 | R-HSA-5083636 | 8.958427e-01 | 0.048 | 0 | 0 |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | R-HSA-434316 | 8.958427e-01 | 0.048 | 0 | 0 |
| Activation of SMO | R-HSA-5635838 | 8.958427e-01 | 0.048 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 8.958427e-01 | 0.048 | 0 | 0 |
| Induction of Cell-Cell Fusion | R-HSA-9733458 | 8.958427e-01 | 0.048 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 8.958427e-01 | 0.048 | 0 | 0 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | R-HSA-399955 | 8.958427e-01 | 0.048 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 8.964460e-01 | 0.047 | 0 | 0 |
| Pyrimidine salvage | R-HSA-73614 | 8.964460e-01 | 0.047 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 8.964460e-01 | 0.047 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 8.972416e-01 | 0.047 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 8.996244e-01 | 0.046 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 8.996244e-01 | 0.046 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 8.996244e-01 | 0.046 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 8.996244e-01 | 0.046 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 8.996244e-01 | 0.046 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 9.039529e-01 | 0.044 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 9.040756e-01 | 0.044 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 9.053716e-01 | 0.043 | 0 | 0 |
| mRNA Capping | R-HSA-72086 | 9.053716e-01 | 0.043 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 9.053716e-01 | 0.043 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 9.053716e-01 | 0.043 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 9.053716e-01 | 0.043 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 9.053716e-01 | 0.043 | 0 | 0 |
| Nitric oxide stimulates guanylate cyclase | R-HSA-392154 | 9.053716e-01 | 0.043 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 9.061335e-01 | 0.043 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 9.065155e-01 | 0.043 | 0 | 0 |
| G beta:gamma signalling through CDC42 | R-HSA-8964616 | 9.069873e-01 | 0.042 | 0 | 0 |
| Defective B4GALT7 causes EDS, progeroid type | R-HSA-3560783 | 9.069873e-01 | 0.042 | 0 | 0 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | R-HSA-4420332 | 9.069873e-01 | 0.042 | 0 | 0 |
| SHC1 events in ERBB4 signaling | R-HSA-1250347 | 9.069873e-01 | 0.042 | 0 | 0 |
| Vitamin B6 activation to pyridoxal phosphate | R-HSA-964975 | 9.069873e-01 | 0.042 | 0 | 0 |
| Coenzyme A biosynthesis | R-HSA-196783 | 9.069873e-01 | 0.042 | 0 | 0 |
| Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | R-HSA-9651496 | 9.069873e-01 | 0.042 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 9.073142e-01 | 0.042 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 9.073142e-01 | 0.042 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 9.105837e-01 | 0.041 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 9.117437e-01 | 0.040 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 9.129676e-01 | 0.040 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 9.129676e-01 | 0.040 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 9.129676e-01 | 0.040 | 0 | 0 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 9.135734e-01 | 0.039 | 0 | 0 |
| NOTCH3 Intracellular Domain Regulates Transcription | R-HSA-9013508 | 9.135734e-01 | 0.039 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 9.135734e-01 | 0.039 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 9.142750e-01 | 0.039 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 9.142750e-01 | 0.039 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 9.142750e-01 | 0.039 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 9.143320e-01 | 0.039 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 9.152083e-01 | 0.038 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 9.156506e-01 | 0.038 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 9.169401e-01 | 0.038 | 0 | 0 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 9.169401e-01 | 0.038 | 0 | 0 |
| Defective B3GAT3 causes JDSSDHD | R-HSA-3560801 | 9.169401e-01 | 0.038 | 0 | 0 |
| Defective C1GALT1C1 causes TNPS | R-HSA-5083632 | 9.169401e-01 | 0.038 | 0 | 0 |
| Glycogen storage diseases | R-HSA-3229121 | 9.169401e-01 | 0.038 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 9.169401e-01 | 0.038 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 9.169401e-01 | 0.038 | 0 | 0 |
| Regulation of NPAS4 gene expression | R-HSA-9768759 | 9.169401e-01 | 0.038 | 0 | 0 |
| GDP-fucose biosynthesis | R-HSA-6787639 | 9.169401e-01 | 0.038 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 9.169401e-01 | 0.038 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 9.169401e-01 | 0.038 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 9.170605e-01 | 0.038 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.191643e-01 | 0.037 | 0 | 0 |
| Activation of GABAB receptors | R-HSA-991365 | 9.208456e-01 | 0.036 | 0 | 0 |
| GABA B receptor activation | R-HSA-977444 | 9.208456e-01 | 0.036 | 0 | 0 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 9.211041e-01 | 0.036 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 9.216837e-01 | 0.035 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 9.246918e-01 | 0.034 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 9.258284e-01 | 0.033 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 9.258284e-01 | 0.033 | 0 | 0 |
| Activated point mutants of FGFR2 | R-HSA-2033519 | 9.258284e-01 | 0.033 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 9.258284e-01 | 0.033 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 9.258284e-01 | 0.033 | 0 | 0 |
| Organic anion transport by SLC5/17/25 transporters | R-HSA-428643 | 9.258284e-01 | 0.033 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 9.258284e-01 | 0.033 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 9.258284e-01 | 0.033 | 0 | 0 |
| Nucleotide-like (purinergic) receptors | R-HSA-418038 | 9.258284e-01 | 0.033 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 9.258284e-01 | 0.033 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 9.300039e-01 | 0.032 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 9.313677e-01 | 0.031 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 9.319481e-01 | 0.031 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 9.326239e-01 | 0.030 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 9.330700e-01 | 0.030 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 9.333264e-01 | 0.030 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 9.337660e-01 | 0.030 | 0 | 0 |
| O2/CO2 exchange in erythrocytes | R-HSA-1480926 | 9.337660e-01 | 0.030 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 9.337660e-01 | 0.030 | 0 | 0 |
| Diseases of hemostasis | R-HSA-9671793 | 9.337660e-01 | 0.030 | 0 | 0 |
| Erythrocytes take up carbon dioxide and release oxygen | R-HSA-1237044 | 9.337660e-01 | 0.030 | 0 | 0 |
| Defective B3GALTL causes PpS | R-HSA-5083635 | 9.343480e-01 | 0.029 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 9.378869e-01 | 0.028 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 9.382574e-01 | 0.028 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 9.388539e-01 | 0.027 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 9.394186e-01 | 0.027 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 9.394186e-01 | 0.027 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 9.394186e-01 | 0.027 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 9.401518e-01 | 0.027 | 0 | 0 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 9.401518e-01 | 0.027 | 0 | 0 |
| Vitamin B5 (pantothenate) metabolism | R-HSA-199220 | 9.401518e-01 | 0.027 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 9.401518e-01 | 0.027 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR2 | R-HSA-5654221 | 9.408546e-01 | 0.026 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 9.408546e-01 | 0.026 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 9.408546e-01 | 0.026 | 0 | 0 |
| Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 9.408546e-01 | 0.026 | 0 | 0 |
| Pregnenolone biosynthesis | R-HSA-196108 | 9.408546e-01 | 0.026 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 9.408546e-01 | 0.026 | 0 | 0 |
| Protein folding | R-HSA-391251 | 9.412069e-01 | 0.026 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 9.412069e-01 | 0.026 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 9.412069e-01 | 0.026 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 9.427674e-01 | 0.026 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 9.427674e-01 | 0.026 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 9.427674e-01 | 0.026 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 9.430095e-01 | 0.025 | 0 | 0 |
| Triglyceride metabolism | R-HSA-8979227 | 9.439676e-01 | 0.025 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 9.454657e-01 | 0.024 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 9.454657e-01 | 0.024 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 9.454657e-01 | 0.024 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 9.468429e-01 | 0.024 | 0 | 0 |
| FGFR2 ligand binding and activation | R-HSA-190241 | 9.471849e-01 | 0.024 | 0 | 0 |
| G-protein activation | R-HSA-202040 | 9.471849e-01 | 0.024 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 9.471849e-01 | 0.024 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 9.471849e-01 | 0.024 | 0 | 0 |
| Matriglycan biosynthesis on DAG1 | R-HSA-9939291 | 9.471849e-01 | 0.024 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 9.471849e-01 | 0.024 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 9.471849e-01 | 0.024 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 9.471849e-01 | 0.024 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 9.471849e-01 | 0.024 | 0 | 0 |
| Intrinsic Pathway of Fibrin Clot Formation | R-HSA-140837 | 9.471849e-01 | 0.024 | 0 | 0 |
| PD-L1(CD274) glycosylation and translocation to plasma membrane | R-HSA-9931295 | 9.471849e-01 | 0.024 | 0 | 0 |
| Synthesis, secretion, and deacylation of Ghrelin | R-HSA-422085 | 9.471849e-01 | 0.024 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 9.471849e-01 | 0.024 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 9.495942e-01 | 0.022 | 0 | 0 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 9.503282e-01 | 0.022 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 9.503282e-01 | 0.022 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 9.514426e-01 | 0.022 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 9.514779e-01 | 0.022 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 9.518097e-01 | 0.021 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 9.528380e-01 | 0.021 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 9.528380e-01 | 0.021 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 9.528380e-01 | 0.021 | 0 | 0 |
| Assembly Of The HIV Virion | R-HSA-175474 | 9.528380e-01 | 0.021 | 0 | 0 |
| Glutathione synthesis and recycling | R-HSA-174403 | 9.528380e-01 | 0.021 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 9.547749e-01 | 0.020 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 9.547749e-01 | 0.020 | 0 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 9.553401e-01 | 0.020 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 9.553535e-01 | 0.020 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 9.578863e-01 | 0.019 | 0 | 0 |
| WNT ligand biogenesis and trafficking | R-HSA-3238698 | 9.578863e-01 | 0.019 | 0 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 9.578863e-01 | 0.019 | 0 | 0 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | R-HSA-9670439 | 9.578863e-01 | 0.019 | 0 | 0 |
| Signaling by KIT in disease | R-HSA-9669938 | 9.578863e-01 | 0.019 | 0 | 0 |
| O-glycosylation of TSR domain-containing proteins | R-HSA-5173214 | 9.588391e-01 | 0.018 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 9.588391e-01 | 0.018 | 0 | 0 |
| Collagen chain trimerization | R-HSA-8948216 | 9.588391e-01 | 0.018 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 9.604165e-01 | 0.018 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 9.612601e-01 | 0.017 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 9.622507e-01 | 0.017 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 9.622507e-01 | 0.017 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | R-HSA-167160 | 9.623945e-01 | 0.017 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE | R-HSA-77075 | 9.623945e-01 | 0.017 | 0 | 0 |
| Termination of O-glycan biosynthesis | R-HSA-977068 | 9.623945e-01 | 0.017 | 0 | 0 |
| Free fatty acids regulate insulin secretion | R-HSA-400451 | 9.623945e-01 | 0.017 | 0 | 0 |
| Carnitine shuttle | R-HSA-200425 | 9.623945e-01 | 0.017 | 0 | 0 |
| Synthesis of pyrophosphates in the cytosol | R-HSA-1855167 | 9.623945e-01 | 0.017 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 9.625518e-01 | 0.017 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 9.645712e-01 | 0.016 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 9.659416e-01 | 0.015 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 9.659416e-01 | 0.015 | 0 | 0 |
| Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 9.664203e-01 | 0.015 | 0 | 0 |
| Thromboxane signalling through TP receptor | R-HSA-428930 | 9.664203e-01 | 0.015 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 9.664203e-01 | 0.015 | 0 | 0 |
| Synthesis of dolichyl-phosphate | R-HSA-446199 | 9.664203e-01 | 0.015 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 9.668930e-01 | 0.015 | 0 | 0 |
| Alpha-oxidation of phytanate | R-HSA-389599 | 9.700154e-01 | 0.013 | 0 | 0 |
| Hyaluronan degradation | R-HSA-2160916 | 9.700154e-01 | 0.013 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 9.700154e-01 | 0.013 | 0 | 0 |
| PIWI-interacting RNA (piRNA) biogenesis | R-HSA-5601884 | 9.700154e-01 | 0.013 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 9.700257e-01 | 0.013 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 9.718568e-01 | 0.012 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 9.718568e-01 | 0.012 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 9.718568e-01 | 0.012 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 9.718568e-01 | 0.012 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 9.719647e-01 | 0.012 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.719647e-01 | 0.012 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 9.721601e-01 | 0.012 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 9.731464e-01 | 0.012 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 9.732258e-01 | 0.012 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 9.732258e-01 | 0.012 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 9.732258e-01 | 0.012 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 9.752299e-01 | 0.011 | 0 | 0 |
| Metabolism of amine-derived hormones | R-HSA-209776 | 9.753620e-01 | 0.011 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.760729e-01 | 0.011 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 9.760926e-01 | 0.011 | 0 | 0 |
| Triglyceride biosynthesis | R-HSA-75109 | 9.760926e-01 | 0.011 | 0 | 0 |
| Synthesis of PE | R-HSA-1483213 | 9.760926e-01 | 0.011 | 0 | 0 |
| Signaling by BMP | R-HSA-201451 | 9.760926e-01 | 0.011 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 9.760926e-01 | 0.011 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 9.766146e-01 | 0.010 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 9.775112e-01 | 0.010 | 0 | 0 |
| Retinoid metabolism and transport | R-HSA-975634 | 9.779081e-01 | 0.010 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 9.789099e-01 | 0.009 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 9.790091e-01 | 0.009 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 9.791140e-01 | 0.009 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 9.792826e-01 | 0.009 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 9.808214e-01 | 0.008 | 0 | 0 |
| Thyroxine biosynthesis | R-HSA-209968 | 9.809386e-01 | 0.008 | 0 | 0 |
| Glucagon-type ligand receptors | R-HSA-420092 | 9.809386e-01 | 0.008 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 9.809386e-01 | 0.008 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 9.810123e-01 | 0.008 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 9.810123e-01 | 0.008 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 9.817693e-01 | 0.008 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 9.826036e-01 | 0.008 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 9.826252e-01 | 0.008 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 9.836309e-01 | 0.007 | 0 | 0 |
| Nucleotide salvage | R-HSA-8956321 | 9.840668e-01 | 0.007 | 0 | 0 |
| Collagen degradation | R-HSA-1442490 | 9.840668e-01 | 0.007 | 0 | 0 |
| Regulation of pyruvate metabolism | R-HSA-9861718 | 9.842361e-01 | 0.007 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 9.847340e-01 | 0.007 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 9.848028e-01 | 0.007 | 0 | 0 |
| Cargo concentration in the ER | R-HSA-5694530 | 9.848028e-01 | 0.007 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 9.848028e-01 | 0.007 | 0 | 0 |
| Synthesis of glycosylphosphatidylinositol (GPI) | R-HSA-162710 | 9.848028e-01 | 0.007 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 9.858616e-01 | 0.006 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 9.864305e-01 | 0.006 | 0 | 0 |
| DAG1 glycosylations | R-HSA-8931838 | 9.864305e-01 | 0.006 | 0 | 0 |
| HS-GAG degradation | R-HSA-2024096 | 9.864305e-01 | 0.006 | 0 | 0 |
| Plasma lipoprotein remodeling | R-HSA-8963899 | 9.870337e-01 | 0.006 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 9.870337e-01 | 0.006 | 0 | 0 |
| Interleukin-10 signaling | R-HSA-6783783 | 9.874883e-01 | 0.005 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.882448e-01 | 0.005 | 0 | 0 |
| Developmental Lineage of Pancreatic Acinar Cells | R-HSA-9925561 | 9.884798e-01 | 0.005 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 9.884906e-01 | 0.005 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 9.891818e-01 | 0.005 | 0 | 0 |
| Glutamate and glutamine metabolism | R-HSA-8964539 | 9.891818e-01 | 0.005 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 9.895171e-01 | 0.005 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 9.896402e-01 | 0.005 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.898525e-01 | 0.004 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 9.902424e-01 | 0.004 | 0 | 0 |
| Metabolism of fat-soluble vitamins | R-HSA-6806667 | 9.902424e-01 | 0.004 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 9.902740e-01 | 0.004 | 0 | 0 |
| Glycosaminoglycan-protein linkage region biosynthesis | R-HSA-1971475 | 9.903406e-01 | 0.004 | 0 | 0 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | R-HSA-6814122 | 9.903406e-01 | 0.004 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 9.903406e-01 | 0.004 | 0 | 0 |
| Hyaluronan metabolism | R-HSA-2142845 | 9.903406e-01 | 0.004 | 0 | 0 |
| Regulation of TLR by endogenous ligand | R-HSA-5686938 | 9.903406e-01 | 0.004 | 0 | 0 |
| Gap junction assembly | R-HSA-190861 | 9.903406e-01 | 0.004 | 0 | 0 |
| Phosphate bond hydrolysis by NUDT proteins | R-HSA-2393930 | 9.903406e-01 | 0.004 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 9.906564e-01 | 0.004 | 0 | 0 |
| Nicotinate metabolism | R-HSA-196807 | 9.906564e-01 | 0.004 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 9.909095e-01 | 0.004 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 9.910658e-01 | 0.004 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 9.912528e-01 | 0.004 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 9.913755e-01 | 0.004 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 9.913755e-01 | 0.004 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 9.913755e-01 | 0.004 | 0 | 0 |
| Defects in vitamin and cofactor metabolism | R-HSA-3296482 | 9.913755e-01 | 0.004 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 9.913755e-01 | 0.004 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 9.913755e-01 | 0.004 | 0 | 0 |
| Synthesis of bile acids and bile salts via 24-hydroxycholesterol | R-HSA-193775 | 9.913755e-01 | 0.004 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 9.914793e-01 | 0.004 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 9.915663e-01 | 0.004 | 0 | 0 |
| HS-GAG biosynthesis | R-HSA-2022928 | 9.922995e-01 | 0.003 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 9.923281e-01 | 0.003 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 9.928727e-01 | 0.003 | 0 | 0 |
| Voltage gated Potassium channels | R-HSA-1296072 | 9.931245e-01 | 0.003 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 9.931245e-01 | 0.003 | 0 | 0 |
| NCAM1 interactions | R-HSA-419037 | 9.931245e-01 | 0.003 | 0 | 0 |
| SLC-mediated transport of organic cations | R-HSA-549127 | 9.931245e-01 | 0.003 | 0 | 0 |
| Beta-oxidation of very long chain fatty acids | R-HSA-390247 | 9.931245e-01 | 0.003 | 0 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.934912e-01 | 0.003 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 9.934912e-01 | 0.003 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 9.935039e-01 | 0.003 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 9.936480e-01 | 0.003 | 0 | 0 |
| Purine salvage | R-HSA-74217 | 9.938612e-01 | 0.003 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.940907e-01 | 0.003 | 0 | 0 |
| Immune System | R-HSA-168256 | 9.942032e-01 | 0.003 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 9.945190e-01 | 0.002 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 9.945190e-01 | 0.002 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 9.945190e-01 | 0.002 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.946781e-01 | 0.002 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.946781e-01 | 0.002 | 0 | 0 |
| ROS and RNS production in phagocytes | R-HSA-1222556 | 9.950507e-01 | 0.002 | 0 | 0 |
| Mitochondrial tRNA aminoacylation | R-HSA-379726 | 9.951064e-01 | 0.002 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 9.954847e-01 | 0.002 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 9.956308e-01 | 0.002 | 0 | 0 |
| Aflatoxin activation and detoxification | R-HSA-5423646 | 9.956308e-01 | 0.002 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 9.956434e-01 | 0.002 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 9.957555e-01 | 0.002 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 9.960593e-01 | 0.002 | 0 | 0 |
| Signaling by Retinoic Acid | R-HSA-5362517 | 9.960593e-01 | 0.002 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 9.960991e-01 | 0.002 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 9.965172e-01 | 0.002 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 9.965764e-01 | 0.001 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 9.968800e-01 | 0.001 | 0 | 0 |
| Defensins | R-HSA-1461973 | 9.968905e-01 | 0.001 | 0 | 0 |
| Pyrimidine catabolism | R-HSA-73621 | 9.968905e-01 | 0.001 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 9.972238e-01 | 0.001 | 0 | 0 |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | R-HSA-196741 | 9.972238e-01 | 0.001 | 0 | 0 |
| Diseases associated with glycosaminoglycan metabolism | R-HSA-3560782 | 9.975214e-01 | 0.001 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 9.975214e-01 | 0.001 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.978493e-01 | 0.001 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 9.980043e-01 | 0.001 | 0 | 0 |
| Carboxyterminal post-translational modifications of tubulin | R-HSA-8955332 | 9.980244e-01 | 0.001 | 0 | 0 |
| Synthesis of PC | R-HSA-1483191 | 9.980244e-01 | 0.001 | 0 | 0 |
| Metabolism of steroid hormones | R-HSA-196071 | 9.980569e-01 | 0.001 | 0 | 0 |
| O-linked glycosylation of mucins | R-HSA-913709 | 9.982447e-01 | 0.001 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.985249e-01 | 0.001 | 0 | 0 |
| Complex IV assembly | R-HSA-9864848 | 9.987449e-01 | 0.001 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 9.987449e-01 | 0.001 | 0 | 0 |
| Purine catabolism | R-HSA-74259 | 9.988327e-01 | 0.001 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 9.989463e-01 | 0.000 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 9.989905e-01 | 0.000 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 9.991935e-01 | 0.000 | 0 | 0 |
| Paracetamol ADME | R-HSA-9753281 | 9.992028e-01 | 0.000 | 0 | 0 |
| Digestion | R-HSA-8935690 | 9.992883e-01 | 0.000 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.993346e-01 | 0.000 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.993346e-01 | 0.000 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.993647e-01 | 0.000 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 9.993695e-01 | 0.000 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.993741e-01 | 0.000 | 0 | 0 |
| Heparan sulfate/heparin (HS-GAG) metabolism | R-HSA-1638091 | 9.994937e-01 | 0.000 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.995471e-01 | 0.000 | 0 | 0 |
| RAB geranylgeranylation | R-HSA-8873719 | 9.995480e-01 | 0.000 | 0 | 0 |
| Glutathione conjugation | R-HSA-156590 | 9.995480e-01 | 0.000 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 9.995480e-01 | 0.000 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 9.996398e-01 | 0.000 | 0 | 0 |
| Digestion and absorption | R-HSA-8963743 | 9.996784e-01 | 0.000 | 0 | 0 |
| CD22 mediated BCR regulation | R-HSA-5690714 | 9.997130e-01 | 0.000 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 9.997130e-01 | 0.000 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.997138e-01 | 0.000 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 9.997427e-01 | 0.000 | 0 | 0 |
| Latent infection - Other responses of Mtb to phagocytosis | R-HSA-1222499 | 9.997438e-01 | 0.000 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 9.997474e-01 | 0.000 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 9.997762e-01 | 0.000 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 9.997911e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | R-HSA-193368 | 9.997958e-01 | 0.000 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 9.998363e-01 | 0.000 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.998704e-01 | 0.000 | 0 | 0 |
| O-linked glycosylation | R-HSA-5173105 | 9.998722e-01 | 0.000 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 9.998759e-01 | 0.000 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 9.998868e-01 | 0.000 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 9.998875e-01 | 0.000 | 0 | 0 |
| Antimicrobial peptides | R-HSA-6803157 | 9.999017e-01 | 0.000 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 9.999155e-01 | 0.000 | 0 | 0 |
| Citric acid cycle (TCA cycle) | R-HSA-71403 | 9.999177e-01 | 0.000 | 0 | 0 |
| Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 9.999292e-01 | 0.000 | 0 | 0 |
| SLC-mediated transport of organic anions | R-HSA-9955298 | 9.999415e-01 | 0.000 | 0 | 0 |
| Cholesterol biosynthesis | R-HSA-191273 | 9.999415e-01 | 0.000 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.999516e-01 | 0.000 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 9.999535e-01 | 0.000 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.999555e-01 | 0.000 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 9.999663e-01 | 0.000 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 9.999679e-01 | 0.000 | 0 | 0 |
| Peroxisomal lipid metabolism | R-HSA-390918 | 9.999704e-01 | 0.000 | 0 | 0 |
| Post-translational modification: synthesis of GPI-anchored proteins | R-HSA-163125 | 9.999726e-01 | 0.000 | 0 | 0 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | R-HSA-420499 | 9.999832e-01 | 0.000 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 9.999841e-01 | 0.000 | 0 | 0 |
| Disease | R-HSA-1643685 | 9.999914e-01 | 0.000 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.999936e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.999962e-01 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 9.999982e-01 | 0.000 | 0 | 0 |
| Nucleotide catabolism | R-HSA-8956319 | 9.999986e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.999989e-01 | 0.000 | 0 | 0 |
| Sensory perception of taste | R-HSA-9717189 | 9.999990e-01 | 0.000 | 0 | 0 |
| Synthesis of substrates in N-glycan biosythesis | R-HSA-446219 | 9.999990e-01 | 0.000 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.999990e-01 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 9.999992e-01 | 0.000 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 9.999995e-01 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 9.999996e-01 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 9.999997e-01 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 9.999998e-01 | 0.000 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.999998e-01 | 0.000 | 0 | 0 |
| Translation | R-HSA-72766 | 9.999998e-01 | 0.000 | 0 | 0 |
| Sensory perception of sweet, bitter, and umami (glutamate) taste | R-HSA-9717207 | 9.999998e-01 | 0.000 | 0 | 0 |
| Regulation of Complement cascade | R-HSA-977606 | 9.999999e-01 | 0.000 | 0 | 0 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | R-HSA-446193 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 1.000000e+00 | 0.000 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 1.000000e+00 | 0.000 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 1.000000e+00 | 0.000 | 0 | 0 |
| Complement cascade | R-HSA-166658 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 1.000000e+00 | 0.000 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 1.000000e+00 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 1.000000e+00 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 1.000000e+00 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 1.000000e+00 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 1.000000e+00 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 1.000000e+00 | 0.000 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 1.000000e+00 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 1.000000e+00 | 0.000 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase II - Conjugation of compounds | R-HSA-156580 | 1.000000e+00 | 0.000 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 1.000000e+00 | 0.000 | 0 | 0 |
| Expression and translocation of olfactory receptors | R-HSA-9752946 | 1.000000e+00 | -0.000 | 0 | 0 |
| Olfactory Signaling Pathway | R-HSA-381753 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
| RSK activation | R-HSA-444257 | 1.000000e+00 | 0.000 | 1 | 1 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| HSF1-dependent transactivation | R-HSA-3371571 | 1.332268e-15 | 14.875 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 1.132427e-14 | 13.946 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 2.364775e-14 | 13.626 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 3.474998e-14 | 13.459 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 4.340972e-14 | 13.362 | 0 | 0 |
| Cellular response to heat stress | R-HSA-3371556 | 1.657563e-13 | 12.781 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 2.793321e-13 | 12.554 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 4.823919e-13 | 12.317 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 5.510037e-13 | 12.259 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 7.691625e-13 | 12.114 | 0 | 0 |
| Cell Cycle | R-HSA-1640170 | 9.142687e-13 | 12.039 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 4.385270e-12 | 11.358 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 4.707901e-12 | 11.327 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 9.310996e-12 | 11.031 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 8.917533e-12 | 11.050 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 1.061518e-11 | 10.974 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 2.389844e-11 | 10.622 | 0 | 0 |
| HSF1 activation | R-HSA-3371511 | 2.807066e-11 | 10.552 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 2.719491e-11 | 10.566 | 0 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 6.018863e-11 | 10.220 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 7.693546e-11 | 10.114 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 9.466661e-11 | 10.024 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 9.466661e-11 | 10.024 | 0 | 0 |
| M Phase | R-HSA-68886 | 1.172178e-10 | 9.931 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 1.795448e-10 | 9.746 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 2.394884e-10 | 9.621 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 2.374185e-10 | 9.624 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 2.374185e-10 | 9.624 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 2.964703e-10 | 9.528 | 0 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 3.407179e-10 | 9.468 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 5.995922e-10 | 9.222 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 7.180702e-10 | 9.144 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 1.453642e-09 | 8.838 | 0 | 0 |
| DNA methylation | R-HSA-5334118 | 1.589288e-09 | 8.799 | 0 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 1.817163e-09 | 8.741 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 3.291198e-09 | 8.483 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 3.307194e-09 | 8.481 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 3.258882e-09 | 8.487 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 3.684359e-09 | 8.434 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 4.006483e-09 | 8.397 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 4.367340e-09 | 8.360 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 4.367340e-09 | 8.360 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 6.031088e-09 | 8.220 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 6.004479e-09 | 8.222 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 6.848226e-09 | 8.164 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 7.779349e-09 | 8.109 | 0 | 0 |
| Signal Transduction | R-HSA-162582 | 7.904987e-09 | 8.102 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 9.111886e-09 | 8.040 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 1.315524e-08 | 7.881 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 1.546179e-08 | 7.811 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 1.648120e-08 | 7.783 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 1.809129e-08 | 7.743 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 2.288325e-08 | 7.640 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 2.550169e-08 | 7.593 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 2.966231e-08 | 7.528 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 3.353720e-08 | 7.474 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 3.353720e-08 | 7.474 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 3.293150e-08 | 7.482 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 3.293150e-08 | 7.482 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 3.526382e-08 | 7.453 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 3.788853e-08 | 7.421 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 4.748715e-08 | 7.323 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 7.155178e-08 | 7.145 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 8.030332e-08 | 7.095 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 9.554416e-08 | 7.020 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 9.846548e-08 | 7.007 | 0 | 0 |
| Meiosis | R-HSA-1500620 | 1.208100e-07 | 6.918 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 1.748148e-07 | 6.757 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 1.898313e-07 | 6.722 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 2.484112e-07 | 6.605 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 2.422908e-07 | 6.616 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 2.372260e-07 | 6.625 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 2.530705e-07 | 6.597 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 2.530705e-07 | 6.597 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 3.253407e-07 | 6.488 | 0 | 0 |
| Depurination | R-HSA-73927 | 3.438740e-07 | 6.464 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 3.529438e-07 | 6.452 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 3.750681e-07 | 6.426 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 3.870315e-07 | 6.412 | 0 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 4.633610e-07 | 6.334 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 5.690549e-07 | 6.245 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 6.252536e-07 | 6.204 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 6.384092e-07 | 6.195 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 6.793040e-07 | 6.168 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 7.723514e-07 | 6.112 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 9.142049e-07 | 6.039 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 9.854311e-07 | 6.006 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 1.002748e-06 | 5.999 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 1.029124e-06 | 5.988 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 1.166319e-06 | 5.933 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 1.289429e-06 | 5.890 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 1.414552e-06 | 5.849 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 1.414552e-06 | 5.849 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 1.479181e-06 | 5.830 | 1 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 1.527749e-06 | 5.816 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 1.736331e-06 | 5.760 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 1.924935e-06 | 5.716 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 2.213818e-06 | 5.655 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 2.306057e-06 | 5.637 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 2.763246e-06 | 5.559 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 2.912581e-06 | 5.536 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 2.964492e-06 | 5.528 | 0 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 3.432513e-06 | 5.464 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 3.920501e-06 | 5.407 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 3.920501e-06 | 5.407 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 4.386161e-06 | 5.358 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 4.440219e-06 | 5.353 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 4.674459e-06 | 5.330 | 1 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 4.729228e-06 | 5.325 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 4.934463e-06 | 5.307 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 6.317972e-06 | 5.199 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 7.102063e-06 | 5.149 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 8.515726e-06 | 5.070 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 8.721267e-06 | 5.059 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 1.015170e-05 | 4.993 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 1.159045e-05 | 4.936 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 1.528794e-05 | 4.816 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 1.660432e-05 | 4.780 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 1.542220e-05 | 4.812 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 1.626606e-05 | 4.789 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 1.889029e-05 | 4.724 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 2.223392e-05 | 4.653 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 2.335252e-05 | 4.632 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 2.744607e-05 | 4.562 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 2.797784e-05 | 4.553 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 3.173625e-05 | 4.498 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 3.187687e-05 | 4.497 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 3.545742e-05 | 4.450 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 3.307484e-05 | 4.481 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 3.462401e-05 | 4.461 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 3.545742e-05 | 4.450 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 3.545742e-05 | 4.450 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 3.658489e-05 | 4.437 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 3.661116e-05 | 4.436 | 0 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 3.751974e-05 | 4.426 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 4.334598e-05 | 4.363 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 4.334598e-05 | 4.363 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 4.607101e-05 | 4.337 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 4.635269e-05 | 4.334 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 5.314246e-05 | 4.275 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 5.314246e-05 | 4.275 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 5.023454e-05 | 4.299 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 5.023454e-05 | 4.299 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 5.063781e-05 | 4.296 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 5.773187e-05 | 4.239 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 6.034695e-05 | 4.219 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 6.590258e-05 | 4.181 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 6.818660e-05 | 4.166 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 7.687445e-05 | 4.114 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 8.415355e-05 | 4.075 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 9.418888e-05 | 4.026 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 9.956576e-05 | 4.002 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 9.969283e-05 | 4.001 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 1.024331e-04 | 3.990 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 1.100500e-04 | 3.958 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 1.080169e-04 | 3.967 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 1.195491e-04 | 3.922 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 1.212810e-04 | 3.916 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 1.484723e-04 | 3.828 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 1.551174e-04 | 3.809 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 1.567093e-04 | 3.805 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 1.866207e-04 | 3.729 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 1.873545e-04 | 3.727 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 1.886381e-04 | 3.724 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 1.886381e-04 | 3.724 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 1.886381e-04 | 3.724 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 1.998253e-04 | 3.699 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 2.106010e-04 | 3.677 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 2.106010e-04 | 3.677 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 2.423527e-04 | 3.616 | 0 | 0 |
| Membrane Trafficking | R-HSA-199991 | 2.479172e-04 | 3.606 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 2.820601e-04 | 3.550 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 2.920047e-04 | 3.535 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 2.920047e-04 | 3.535 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 2.921494e-04 | 3.534 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 3.169812e-04 | 3.499 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 3.247503e-04 | 3.488 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 3.247503e-04 | 3.488 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 3.386422e-04 | 3.470 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 3.386422e-04 | 3.470 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 3.548996e-04 | 3.450 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 3.576335e-04 | 3.447 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 3.866795e-04 | 3.413 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 4.132590e-04 | 3.384 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 4.407899e-04 | 3.356 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 4.491332e-04 | 3.348 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 4.711486e-04 | 3.327 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 5.053396e-04 | 3.296 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 6.097133e-04 | 3.215 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 6.408920e-04 | 3.193 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 6.584239e-04 | 3.181 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 6.584239e-04 | 3.181 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 6.584239e-04 | 3.181 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 6.584239e-04 | 3.181 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 6.584239e-04 | 3.181 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 7.166663e-04 | 3.145 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 8.010268e-04 | 3.096 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 8.046059e-04 | 3.094 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 8.199220e-04 | 3.086 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 8.199220e-04 | 3.086 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 8.794462e-04 | 3.056 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 9.033551e-04 | 3.044 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 9.134725e-04 | 3.039 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 9.282500e-04 | 3.032 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 9.386472e-04 | 3.027 | 0 | 0 |
| Translesion Synthesis by POLH | R-HSA-110320 | 9.585553e-04 | 3.018 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 9.585553e-04 | 3.018 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 9.992692e-04 | 3.000 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 1.070309e-03 | 2.970 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 1.092619e-03 | 2.962 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 1.116720e-03 | 2.952 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 1.194967e-03 | 2.923 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 1.238376e-03 | 2.907 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 1.238376e-03 | 2.907 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 1.385346e-03 | 2.858 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 1.393002e-03 | 2.856 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 1.427221e-03 | 2.846 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 1.540027e-03 | 2.812 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 1.666404e-03 | 2.778 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 1.656574e-03 | 2.781 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 1.656574e-03 | 2.781 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 1.481503e-03 | 2.829 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 1.540027e-03 | 2.812 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 1.462283e-03 | 2.835 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 1.731422e-03 | 2.762 | 0 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 1.744399e-03 | 2.758 | 0 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 1.809841e-03 | 2.742 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 1.873685e-03 | 2.727 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 1.958575e-03 | 2.708 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 1.991417e-03 | 2.701 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 1.991417e-03 | 2.701 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 1.991417e-03 | 2.701 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 2.020286e-03 | 2.695 | 0 | 0 |
| PLC beta mediated events | R-HSA-112043 | 2.055469e-03 | 2.687 | 0 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 2.056063e-03 | 2.687 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 2.138627e-03 | 2.670 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 2.199112e-03 | 2.658 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 2.229386e-03 | 2.652 | 0 | 0 |
| IRAK1 recruits IKK complex | R-HSA-937039 | 2.279455e-03 | 2.642 | 0 | 0 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | R-HSA-975144 | 2.279455e-03 | 2.642 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 2.279455e-03 | 2.642 | 0 | 0 |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | R-HSA-9828211 | 2.320898e-03 | 2.634 | 0 | 0 |
| Myoclonic epilepsy of Lafora | R-HSA-3785653 | 2.320898e-03 | 2.634 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 2.406217e-03 | 2.619 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 2.415633e-03 | 2.617 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 2.415633e-03 | 2.617 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 2.545655e-03 | 2.594 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 2.648382e-03 | 2.577 | 0 | 0 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 2.648382e-03 | 2.577 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 2.764658e-03 | 2.558 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 2.827185e-03 | 2.549 | 0 | 0 |
| FLT3 signaling by CBL mutants | R-HSA-9706377 | 2.827185e-03 | 2.549 | 0 | 0 |
| Inactivation of CDC42 and RAC1 | R-HSA-428543 | 3.356045e-03 | 2.474 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 3.064113e-03 | 2.514 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 3.224116e-03 | 2.492 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 3.224116e-03 | 2.492 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex | R-HSA-937042 | 3.356045e-03 | 2.474 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 3.356045e-03 | 2.474 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 3.399410e-03 | 2.469 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 3.399410e-03 | 2.469 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 3.411403e-03 | 2.467 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 3.411403e-03 | 2.467 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 3.411403e-03 | 2.467 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 3.498214e-03 | 2.456 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 3.703820e-03 | 2.431 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 3.748716e-03 | 2.426 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 3.748716e-03 | 2.426 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 3.795448e-03 | 2.421 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 3.936699e-03 | 2.405 | 0 | 0 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 3.951477e-03 | 2.403 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 4.053375e-03 | 2.392 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 4.231865e-03 | 2.373 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 4.231865e-03 | 2.373 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 4.436982e-03 | 2.353 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 4.436982e-03 | 2.353 | 0 | 0 |
| Influenza Infection | R-HSA-168255 | 4.503172e-03 | 2.346 | 0 | 0 |
| RUNX1 regulates expression of components of tight junctions | R-HSA-8935964 | 4.524927e-03 | 2.344 | 0 | 0 |
| Maturation of protein E | R-HSA-9694493 | 4.524927e-03 | 2.344 | 0 | 0 |
| Maturation of protein E | R-HSA-9683683 | 4.524927e-03 | 2.344 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 4.687409e-03 | 2.329 | 0 | 0 |
| Josephin domain DUBs | R-HSA-5689877 | 4.687409e-03 | 2.329 | 0 | 0 |
| Pexophagy | R-HSA-9664873 | 4.687409e-03 | 2.329 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 4.706449e-03 | 2.327 | 0 | 0 |
| Kinesins | R-HSA-983189 | 4.743134e-03 | 2.324 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 5.078829e-03 | 2.294 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 5.103973e-03 | 2.292 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 5.215478e-03 | 2.283 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 5.215478e-03 | 2.283 | 0 | 0 |
| Translesion synthesis by REV1 | R-HSA-110312 | 5.215478e-03 | 2.283 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 5.324245e-03 | 2.274 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 5.510150e-03 | 2.259 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 5.838410e-03 | 2.234 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 6.356492e-03 | 2.197 | 0 | 0 |
| Translesion synthesis by POLI | R-HSA-5656121 | 6.631546e-03 | 2.178 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 7.520137e-03 | 2.124 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 7.506085e-03 | 2.125 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 6.148105e-03 | 2.211 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 7.675245e-03 | 2.115 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 7.067877e-03 | 2.151 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 6.184900e-03 | 2.209 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 6.631546e-03 | 2.178 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 7.026077e-03 | 2.153 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 7.506085e-03 | 2.125 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 7.675245e-03 | 2.115 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 7.508098e-03 | 2.124 | 0 | 0 |
| Alpha-protein kinase 1 signaling pathway | R-HSA-9645460 | 6.356492e-03 | 2.197 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 6.249616e-03 | 2.204 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 6.668417e-03 | 2.176 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 7.931277e-03 | 2.101 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 8.090636e-03 | 2.092 | 0 | 0 |
| Disorders of Developmental Biology | R-HSA-9675151 | 8.307464e-03 | 2.081 | 0 | 0 |
| Translesion synthesis by POLK | R-HSA-5655862 | 8.307464e-03 | 2.081 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 8.307464e-03 | 2.081 | 0 | 0 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 8.307464e-03 | 2.081 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 8.364550e-03 | 2.078 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 8.366312e-03 | 2.077 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 8.366312e-03 | 2.077 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 8.381196e-03 | 2.077 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 8.403542e-03 | 2.076 | 0 | 0 |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | R-HSA-9824878 | 8.403542e-03 | 2.076 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 8.690483e-03 | 2.061 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 8.913605e-03 | 2.050 | 0 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 9.057178e-03 | 2.043 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 1.001138e-02 | 2.000 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 1.001327e-02 | 1.999 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 1.026033e-02 | 1.989 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 1.080046e-02 | 1.967 | 0 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 1.081265e-02 | 1.966 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 1.086684e-02 | 1.964 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 1.086684e-02 | 1.964 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 1.086684e-02 | 1.964 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 1.114816e-02 | 1.953 | 1 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 1.187139e-02 | 1.925 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 1.198032e-02 | 1.922 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 1.198032e-02 | 1.922 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 1.198032e-02 | 1.922 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 1.198032e-02 | 1.922 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 1.198032e-02 | 1.922 | 0 | 0 |
| Loss of MECP2 binding ability to 5hmC-DNA | R-HSA-9022534 | 1.198032e-02 | 1.922 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 1.232477e-02 | 1.909 | 0 | 0 |
| PKA activation | R-HSA-163615 | 1.253501e-02 | 1.902 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 1.253501e-02 | 1.902 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 1.258967e-02 | 1.900 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 1.325868e-02 | 1.877 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 1.326248e-02 | 1.877 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 1.337219e-02 | 1.874 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 1.337219e-02 | 1.874 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 1.337219e-02 | 1.874 | 0 | 0 |
| Modulation by Mtb of host immune system | R-HSA-9637628 | 1.337219e-02 | 1.874 | 0 | 0 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 1.378207e-02 | 1.861 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 1.468828e-02 | 1.833 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 1.476539e-02 | 1.831 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 1.500269e-02 | 1.824 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 1.504283e-02 | 1.823 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 1.504283e-02 | 1.823 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 1.504283e-02 | 1.823 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 1.513261e-02 | 1.820 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 2.033524e-02 | 1.692 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 2.033524e-02 | 1.692 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 1.635141e-02 | 1.786 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 1.868613e-02 | 1.728 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 1.898415e-02 | 1.722 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 1.679576e-02 | 1.775 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 1.718181e-02 | 1.765 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 1.583506e-02 | 1.800 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 2.033524e-02 | 1.692 | 0 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 2.006126e-02 | 1.698 | 0 | 0 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | R-HSA-5684264 | 1.718181e-02 | 1.765 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 1.673580e-02 | 1.776 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 1.754888e-02 | 1.756 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 1.687915e-02 | 1.773 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 1.639746e-02 | 1.785 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 1.549897e-02 | 1.810 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 1.816081e-02 | 1.741 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 2.041720e-02 | 1.690 | 0 | 0 |
| S Phase | R-HSA-69242 | 2.085195e-02 | 1.681 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 2.109514e-02 | 1.676 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 2.109514e-02 | 1.676 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 2.109514e-02 | 1.676 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 2.109514e-02 | 1.676 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 2.109514e-02 | 1.676 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 2.109514e-02 | 1.676 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 2.124983e-02 | 1.673 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 2.124983e-02 | 1.673 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 2.140130e-02 | 1.670 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 2.140130e-02 | 1.670 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 2.140130e-02 | 1.670 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 2.140130e-02 | 1.670 | 0 | 0 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 2.140130e-02 | 1.670 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 2.231790e-02 | 1.651 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 2.265726e-02 | 1.645 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 2.300188e-02 | 1.638 | 0 | 0 |
| Apoptosis induced DNA fragmentation | R-HSA-140342 | 2.300188e-02 | 1.638 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 2.330728e-02 | 1.633 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 2.405295e-02 | 1.619 | 0 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 2.423880e-02 | 1.615 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 2.429628e-02 | 1.614 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 2.429628e-02 | 1.614 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 2.511013e-02 | 1.600 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 2.511013e-02 | 1.600 | 0 | 0 |
| Inactivation of CSF3 (G-CSF) signaling | R-HSA-9705462 | 2.511013e-02 | 1.600 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 2.511013e-02 | 1.600 | 0 | 0 |
| Manipulation of host energy metabolism | R-HSA-9636667 | 2.555229e-02 | 1.593 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 2.555229e-02 | 1.593 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 2.573353e-02 | 1.590 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 2.664193e-02 | 1.574 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 2.664193e-02 | 1.574 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 2.664193e-02 | 1.574 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 2.664193e-02 | 1.574 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 2.664193e-02 | 1.574 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 2.680315e-02 | 1.572 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 2.680315e-02 | 1.572 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 2.680315e-02 | 1.572 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 2.680315e-02 | 1.572 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 2.761437e-02 | 1.559 | 0 | 0 |
| Noncanonical activation of NOTCH3 | R-HSA-9017802 | 2.872487e-02 | 1.542 | 0 | 0 |
| Loss of MECP2 binding ability to the NCoR/SMRT complex | R-HSA-9022537 | 2.872487e-02 | 1.542 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 2.906136e-02 | 1.537 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 2.941009e-02 | 1.532 | 1 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 2.953229e-02 | 1.530 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 3.035365e-02 | 1.518 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 3.047365e-02 | 1.516 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 3.050941e-02 | 1.516 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 3.055936e-02 | 1.515 | 0 | 0 |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | R-HSA-975110 | 3.055936e-02 | 1.515 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 3.164158e-02 | 1.500 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 3.164158e-02 | 1.500 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 3.200967e-02 | 1.495 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 3.200967e-02 | 1.495 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 3.423821e-02 | 1.465 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 3.423821e-02 | 1.465 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 3.454523e-02 | 1.462 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 3.459545e-02 | 1.461 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 3.465426e-02 | 1.460 | 0 | 0 |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | 3.598109e-02 | 1.444 | 0 | 0 |
| Reduction of cytosolic Ca++ levels | R-HSA-418359 | 3.598109e-02 | 1.444 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 3.598109e-02 | 1.444 | 0 | 0 |
| Regulation of FZD by ubiquitination | R-HSA-4641263 | 3.614835e-02 | 1.442 | 0 | 0 |
| Glycogen storage diseases | R-HSA-3229121 | 3.614835e-02 | 1.442 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 3.614835e-02 | 1.442 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 3.646976e-02 | 1.438 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 3.786754e-02 | 1.422 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 3.855853e-02 | 1.414 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 3.872226e-02 | 1.412 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 3.960804e-02 | 1.402 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 3.974115e-02 | 1.401 | 1 | 1 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 3.974115e-02 | 1.401 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 4.064655e-02 | 1.391 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 4.064655e-02 | 1.391 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 4.174576e-02 | 1.379 | 0 | 0 |
| Regulation of TP53 Expression | R-HSA-6804754 | 4.307755e-02 | 1.366 | 0 | 0 |
| Regulation of cortical dendrite branching | R-HSA-8985801 | 4.307755e-02 | 1.366 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 4.987906e-02 | 1.302 | 0 | 0 |
| SLBP independent Processing of Histone Pre-mRNAs | R-HSA-111367 | 4.987906e-02 | 1.302 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 4.987906e-02 | 1.302 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 6.262440e-02 | 1.203 | 0 | 0 |
| SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | R-HSA-77588 | 6.262440e-02 | 1.203 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 6.262440e-02 | 1.203 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 6.262440e-02 | 1.203 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 5.243185e-02 | 1.280 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 6.195506e-02 | 1.208 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 4.910344e-02 | 1.309 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 5.648213e-02 | 1.248 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 4.412833e-02 | 1.355 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 4.998333e-02 | 1.301 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 4.871899e-02 | 1.312 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 4.198443e-02 | 1.377 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 5.112772e-02 | 1.291 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 5.153669e-02 | 1.288 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 4.998333e-02 | 1.301 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 4.325032e-02 | 1.364 | 0 | 0 |
| Membrane binding and targetting of GAG proteins | R-HSA-174490 | 5.243185e-02 | 1.280 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 4.910344e-02 | 1.309 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 5.995626e-02 | 1.222 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 4.910344e-02 | 1.309 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 4.896032e-02 | 1.310 | 1 | 0 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | R-HSA-174495 | 6.195506e-02 | 1.208 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 5.648213e-02 | 1.248 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 5.112772e-02 | 1.291 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 4.364239e-02 | 1.360 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 5.629266e-02 | 1.250 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 5.648213e-02 | 1.248 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 6.161679e-02 | 1.210 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 5.415553e-02 | 1.266 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 4.325032e-02 | 1.364 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 5.112772e-02 | 1.291 | 0 | 0 |
| Uptake and function of diphtheria toxin | R-HSA-5336415 | 4.987906e-02 | 1.302 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 5.640834e-02 | 1.249 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 4.361690e-02 | 1.360 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 4.393569e-02 | 1.357 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | R-HSA-2691232 | 4.377109e-02 | 1.359 | 0 | 0 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | R-HSA-2691230 | 4.377109e-02 | 1.359 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 5.171562e-02 | 1.286 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 5.153669e-02 | 1.288 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 4.371833e-02 | 1.359 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 4.640901e-02 | 1.333 | 0 | 0 |
| VLDLR internalisation and degradation | R-HSA-8866427 | 4.377109e-02 | 1.359 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 6.305942e-02 | 1.200 | 0 | 0 |
| Loss of MECP2 binding ability to 5mC-DNA | R-HSA-9022538 | 6.385295e-02 | 1.195 | 0 | 0 |
| Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | R-HSA-9673766 | 6.385295e-02 | 1.195 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 6.446308e-02 | 1.191 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 6.446308e-02 | 1.191 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 6.490756e-02 | 1.188 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 6.545198e-02 | 1.184 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 6.561225e-02 | 1.183 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 6.612402e-02 | 1.180 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 6.675905e-02 | 1.175 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 6.801421e-02 | 1.167 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 6.848455e-02 | 1.164 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 7.028447e-02 | 1.153 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 7.028447e-02 | 1.153 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 7.232438e-02 | 1.141 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 7.232438e-02 | 1.141 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 7.257427e-02 | 1.139 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 7.266024e-02 | 1.139 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 7.266024e-02 | 1.139 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 7.302145e-02 | 1.137 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 7.309593e-02 | 1.136 | 1 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 7.671492e-02 | 1.115 | 0 | 0 |
| Unwinding of DNA | R-HSA-176974 | 7.671492e-02 | 1.115 | 0 | 0 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | R-HSA-9013700 | 7.671492e-02 | 1.115 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 7.671492e-02 | 1.115 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 7.816153e-02 | 1.107 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 7.816153e-02 | 1.107 | 0 | 0 |
| Loss of Function of TP53 in Cancer | R-HSA-9723907 | 7.847598e-02 | 1.105 | 0 | 0 |
| Loss of function of TP53 in cancer due to loss of tetramerization ability | R-HSA-9723905 | 7.847598e-02 | 1.105 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 7.926090e-02 | 1.101 | 0 | 0 |
| Regulation of pyruvate metabolism | R-HSA-9861718 | 7.926090e-02 | 1.101 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 8.085313e-02 | 1.092 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 8.110322e-02 | 1.091 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 8.221266e-02 | 1.085 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 8.221266e-02 | 1.085 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 8.221266e-02 | 1.085 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 8.330577e-02 | 1.079 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 8.351633e-02 | 1.078 | 0 | 0 |
| Regulation of BACH1 activity | R-HSA-9708530 | 8.351633e-02 | 1.078 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 8.351633e-02 | 1.078 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 8.376159e-02 | 1.077 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 8.376159e-02 | 1.077 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 8.376159e-02 | 1.077 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 8.464678e-02 | 1.072 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 8.470193e-02 | 1.072 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 8.610199e-02 | 1.065 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 8.683693e-02 | 1.061 | 0 | 0 |
| MECP2 regulates transcription of genes involved in GABA signaling | R-HSA-9022927 | 8.726125e-02 | 1.059 | 0 | 0 |
| Inhibition of TSC complex formation by PKB | R-HSA-165181 | 8.726125e-02 | 1.059 | 0 | 0 |
| NFE2L2 regulating ER-stress associated genes | R-HSA-9818035 | 8.726125e-02 | 1.059 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 8.726125e-02 | 1.059 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 8.995645e-02 | 1.046 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 9.205800e-02 | 1.036 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 9.205800e-02 | 1.036 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 9.205800e-02 | 1.036 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 9.262073e-02 | 1.033 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 9.380530e-02 | 1.028 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 9.447340e-02 | 1.025 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 9.447340e-02 | 1.025 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 9.447340e-02 | 1.025 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 9.447340e-02 | 1.025 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 9.447340e-02 | 1.025 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 9.468542e-02 | 1.024 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 9.468542e-02 | 1.024 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 9.468542e-02 | 1.024 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 9.481769e-02 | 1.023 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 9.500038e-02 | 1.022 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 9.519511e-02 | 1.021 | 0 | 0 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 9.550111e-02 | 1.020 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 9.641433e-02 | 1.016 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 9.996682e-02 | 1.000 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 1.004532e-01 | 0.998 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 1.024704e-01 | 0.989 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 1.033829e-01 | 0.986 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 1.037093e-01 | 0.984 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 1.037093e-01 | 0.984 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 1.037093e-01 | 0.984 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 1.037093e-01 | 0.984 | 1 | 1 |
| Sensory processing of sound | R-HSA-9659379 | 1.059291e-01 | 0.975 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 1.072800e-01 | 0.969 | 0 | 0 |
| LGI-ADAM interactions | R-HSA-5682910 | 1.085519e-01 | 0.964 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 1.108227e-01 | 0.955 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 1.108227e-01 | 0.955 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 1.108227e-01 | 0.955 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 1.112152e-01 | 0.954 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 1.120943e-01 | 0.950 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 1.120943e-01 | 0.950 | 0 | 0 |
| NFE2L2 regulating inflammation associated genes | R-HSA-9818026 | 1.127619e-01 | 0.948 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 1.127619e-01 | 0.948 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 1.127619e-01 | 0.948 | 0 | 0 |
| Pyrophosphate hydrolysis | R-HSA-71737 | 1.127619e-01 | 0.948 | 0 | 0 |
| Toxicity of botulinum toxin type C (botC) | R-HSA-5250971 | 1.127619e-01 | 0.948 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 1.131417e-01 | 0.946 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 1.131641e-01 | 0.946 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 1.189252e-01 | 0.925 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 1.195237e-01 | 0.923 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 1.217035e-01 | 0.915 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 1.230388e-01 | 0.910 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 1.230388e-01 | 0.910 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 1.230388e-01 | 0.910 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 1.230388e-01 | 0.910 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 1.230895e-01 | 0.910 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 1.230895e-01 | 0.910 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 1.230895e-01 | 0.910 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 1.230895e-01 | 0.910 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 1.245250e-01 | 0.905 | 0 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 1.248380e-01 | 0.904 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 1.260887e-01 | 0.899 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 1.274372e-01 | 0.895 | 0 | 0 |
| Response of Mtb to phagocytosis | R-HSA-9637690 | 1.285660e-01 | 0.891 | 0 | 0 |
| Regulation of PAK-2p34 activity by PS-GAP/RHG10 | R-HSA-211728 | 1.507978e-01 | 0.822 | 0 | 0 |
| Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) | R-HSA-5619043 | 1.507978e-01 | 0.822 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH6 | R-HSA-5632968 | 1.507978e-01 | 0.822 | 0 | 0 |
| IKBKB deficiency causes SCID | R-HSA-5602636 | 2.174477e-01 | 0.663 | 0 | 0 |
| Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) | R-HSA-5619054 | 2.174477e-01 | 0.663 | 0 | 0 |
| Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) | R-HSA-5619039 | 2.174477e-01 | 0.663 | 0 | 0 |
| Defective SLC6A2 causes orthostatic intolerance (OI) | R-HSA-5619109 | 2.174477e-01 | 0.663 | 0 | 0 |
| IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | R-HSA-5603027 | 2.174477e-01 | 0.663 | 0 | 0 |
| PKB-mediated events | R-HSA-109703 | 1.398830e-01 | 0.854 | 0 | 0 |
| PDE3B signalling | R-HSA-165160 | 1.398830e-01 | 0.854 | 0 | 0 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | 1.398830e-01 | 0.854 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 1.682135e-01 | 0.774 | 0 | 0 |
| MECP2 regulates transcription factors | R-HSA-9022707 | 1.973970e-01 | 0.705 | 0 | 0 |
| Recycling of eIF2:GDP | R-HSA-72731 | 1.973970e-01 | 0.705 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 1.445576e-01 | 0.840 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 1.445576e-01 | 0.840 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 2.271255e-01 | 0.644 | 0 | 0 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 1.638463e-01 | 0.786 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 1.638463e-01 | 0.786 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 1.638463e-01 | 0.786 | 0 | 0 |
| Pre-NOTCH Processing in Golgi | R-HSA-1912420 | 1.358376e-01 | 0.867 | 0 | 0 |
| NFE2L2 regulating MDR associated enzymes | R-HSA-9818032 | 2.571340e-01 | 0.590 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 2.571340e-01 | 0.590 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 2.571340e-01 | 0.590 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 2.571340e-01 | 0.590 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 2.571340e-01 | 0.590 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 1.505989e-01 | 0.822 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 2.044398e-01 | 0.689 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 2.255295e-01 | 0.647 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 2.255295e-01 | 0.647 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 1.488091e-01 | 0.827 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 1.488091e-01 | 0.827 | 0 | 0 |
| mRNA Capping | R-HSA-72086 | 1.616422e-01 | 0.791 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 2.320461e-01 | 0.634 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 1.314289e-01 | 0.881 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 1.576468e-01 | 0.802 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 1.902886e-01 | 0.721 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 1.679560e-01 | 0.775 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 1.489455e-01 | 0.827 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 1.581081e-01 | 0.801 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 2.465419e-01 | 0.608 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 2.235435e-01 | 0.651 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 2.353683e-01 | 0.628 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 1.902886e-01 | 0.721 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 1.476377e-01 | 0.831 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 1.902886e-01 | 0.721 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 1.749018e-01 | 0.757 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 1.333205e-01 | 0.875 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 1.782118e-01 | 0.749 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 2.470107e-01 | 0.607 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 2.149113e-01 | 0.668 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 1.550465e-01 | 0.810 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 1.885587e-01 | 0.725 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 1.894243e-01 | 0.723 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 1.894243e-01 | 0.723 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 1.689354e-01 | 0.772 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 2.465419e-01 | 0.608 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 1.894243e-01 | 0.723 | 0 | 0 |
| Translation | R-HSA-72766 | 2.117495e-01 | 0.674 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 2.209750e-01 | 0.656 | 0 | 0 |
| Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 1.398830e-01 | 0.854 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 2.026685e-01 | 0.693 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 2.026685e-01 | 0.693 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 1.404505e-01 | 0.852 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 1.638463e-01 | 0.786 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 1.325777e-01 | 0.878 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 2.282553e-01 | 0.642 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 2.289404e-01 | 0.640 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 1.782118e-01 | 0.749 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 2.026685e-01 | 0.693 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 2.414195e-01 | 0.617 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 2.181768e-01 | 0.661 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 2.028009e-01 | 0.693 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 2.353683e-01 | 0.628 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 1.940854e-01 | 0.712 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 2.255295e-01 | 0.647 | 0 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 2.049099e-01 | 0.688 | 0 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 2.049099e-01 | 0.688 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 1.680581e-01 | 0.775 | 0 | 0 |
| Inhibition of Host mRNA Processing and RNA Silencing | R-HSA-168315 | 2.174477e-01 | 0.663 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH2 | R-HSA-5632928 | 2.174477e-01 | 0.663 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 1.838435e-01 | 0.736 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 2.044398e-01 | 0.689 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 1.616422e-01 | 0.791 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 1.782118e-01 | 0.749 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 1.785529e-01 | 0.748 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 2.119343e-01 | 0.674 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 2.473931e-01 | 0.607 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 1.749989e-01 | 0.757 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 2.533539e-01 | 0.596 | 0 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 1.885587e-01 | 0.725 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 1.487837e-01 | 0.827 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 2.169422e-01 | 0.664 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 1.823793e-01 | 0.739 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 2.049099e-01 | 0.688 | 0 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 2.169422e-01 | 0.664 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 1.676748e-01 | 0.776 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 1.379406e-01 | 0.860 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 1.998554e-01 | 0.699 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 2.452920e-01 | 0.610 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 1.398830e-01 | 0.854 | 0 | 0 |
| Nef and signal transduction | R-HSA-164944 | 1.682135e-01 | 0.774 | 0 | 0 |
| CHL1 interactions | R-HSA-447041 | 1.973970e-01 | 0.705 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 2.316060e-01 | 0.635 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 2.119343e-01 | 0.674 | 0 | 0 |
| Calnexin/calreticulin cycle | R-HSA-901042 | 2.465419e-01 | 0.608 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 2.255295e-01 | 0.647 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 2.494988e-01 | 0.603 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 1.358376e-01 | 0.867 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 1.488091e-01 | 0.827 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 1.616422e-01 | 0.791 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 2.465419e-01 | 0.608 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 1.659383e-01 | 0.780 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 1.797782e-01 | 0.745 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 1.476377e-01 | 0.831 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 1.325768e-01 | 0.878 | 0 | 0 |
| TGFBR3 PTM regulation | R-HSA-9839383 | 2.271255e-01 | 0.644 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 2.571340e-01 | 0.590 | 0 | 0 |
| Receptor-type tyrosine-protein phosphatases | R-HSA-388844 | 2.255295e-01 | 0.647 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 2.169422e-01 | 0.664 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 2.169422e-01 | 0.664 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 2.316060e-01 | 0.635 | 0 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 1.487913e-01 | 0.827 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 1.902886e-01 | 0.721 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 1.937236e-01 | 0.713 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 1.659383e-01 | 0.780 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 1.405604e-01 | 0.852 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 1.785529e-01 | 0.748 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 2.414195e-01 | 0.617 | 0 | 0 |
| Regulation of NFE2L2 gene expression | R-HSA-9818749 | 1.682135e-01 | 0.774 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 1.981467e-01 | 0.703 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 1.405604e-01 | 0.852 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 1.379406e-01 | 0.860 | 0 | 0 |
| Cation-coupled Chloride cotransporters | R-HSA-426117 | 1.973970e-01 | 0.705 | 0 | 0 |
| Activation of the TFAP2 (AP-2) family of transcription factors | R-HSA-8866907 | 2.571340e-01 | 0.590 | 0 | 0 |
| Assembly Of The HIV Virion | R-HSA-175474 | 1.818048e-01 | 0.740 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 1.400134e-01 | 0.854 | 0 | 0 |
| MAP kinase activation | R-HSA-450294 | 2.076097e-01 | 0.683 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 1.932772e-01 | 0.714 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 1.307170e-01 | 0.884 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 2.347124e-01 | 0.629 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 2.028009e-01 | 0.693 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 2.571340e-01 | 0.590 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 2.125140e-01 | 0.673 | 0 | 0 |
| RUNX3 Regulates Immune Response and Cell Migration | R-HSA-8949275 | 1.973970e-01 | 0.705 | 0 | 0 |
| Respiratory syncytial virus genome replication | R-HSA-9834752 | 2.571340e-01 | 0.590 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 2.571340e-01 | 0.590 | 0 | 0 |
| Prevention of phagosomal-lysosomal fusion | R-HSA-9636383 | 1.659383e-01 | 0.780 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 2.427007e-01 | 0.615 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 1.999958e-01 | 0.699 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 2.153312e-01 | 0.667 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 1.818048e-01 | 0.740 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 1.516926e-01 | 0.819 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 1.897532e-01 | 0.722 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 1.596874e-01 | 0.797 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 2.271255e-01 | 0.644 | 0 | 0 |
| PD-L1(CD274) glycosylation and translocation to plasma membrane | R-HSA-9931295 | 1.659383e-01 | 0.780 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 2.465419e-01 | 0.608 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 2.201563e-01 | 0.657 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 2.395257e-01 | 0.621 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 2.604337e-01 | 0.584 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 2.617180e-01 | 0.582 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 2.617180e-01 | 0.582 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 2.617180e-01 | 0.582 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 2.636944e-01 | 0.579 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 2.672180e-01 | 0.573 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 2.672180e-01 | 0.573 | 0 | 0 |
| Suppression of phagosomal maturation | R-HSA-9637687 | 2.672180e-01 | 0.573 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 2.683801e-01 | 0.571 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 2.683801e-01 | 0.571 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 2.683801e-01 | 0.571 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 2.683801e-01 | 0.571 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 2.683801e-01 | 0.571 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 2.683801e-01 | 0.571 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 2.683801e-01 | 0.571 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 2.687865e-01 | 0.571 | 0 | 0 |
| Uptake and function of anthrax toxins | R-HSA-5210891 | 2.687865e-01 | 0.571 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 2.715007e-01 | 0.566 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 2.719779e-01 | 0.565 | 0 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 2.742587e-01 | 0.562 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 2.771021e-01 | 0.557 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 2.771021e-01 | 0.557 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 2.771021e-01 | 0.557 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 2.788703e-01 | 0.555 | 0 | 0 |
| Stimulation of the cell death response by PAK-2p34 | R-HSA-211736 | 2.788703e-01 | 0.555 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 2.788703e-01 | 0.555 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 2.788703e-01 | 0.555 | 0 | 0 |
| Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | R-HSA-5619089 | 2.788703e-01 | 0.555 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 2.788703e-01 | 0.555 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 2.788703e-01 | 0.555 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 2.788703e-01 | 0.555 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 2.788703e-01 | 0.555 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 2.788703e-01 | 0.555 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 2.788703e-01 | 0.555 | 0 | 0 |
| Glycogen storage disease type XV (GYG1) | R-HSA-3814836 | 2.788703e-01 | 0.555 | 0 | 0 |
| Glycogen storage disease type 0 (muscle GYS1) | R-HSA-3828062 | 2.788703e-01 | 0.555 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 2.788703e-01 | 0.555 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 2.788703e-01 | 0.555 | 0 | 0 |
| Interleukin-33 signaling | R-HSA-9014843 | 2.788703e-01 | 0.555 | 0 | 0 |
| Activation, myristolyation of BID and translocation to mitochondria | R-HSA-75108 | 2.788703e-01 | 0.555 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 2.821323e-01 | 0.550 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 2.821323e-01 | 0.550 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 2.824459e-01 | 0.549 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 2.827124e-01 | 0.549 | 0 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 2.827124e-01 | 0.549 | 0 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 2.827124e-01 | 0.549 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 2.827124e-01 | 0.549 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 2.827124e-01 | 0.549 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 2.841092e-01 | 0.547 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 2.851534e-01 | 0.545 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 2.851534e-01 | 0.545 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 2.851534e-01 | 0.545 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 2.851534e-01 | 0.545 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 2.851534e-01 | 0.545 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 2.851534e-01 | 0.545 | 0 | 0 |
| ER Quality Control Compartment (ERQC) | R-HSA-901032 | 2.851534e-01 | 0.545 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 2.851534e-01 | 0.545 | 0 | 0 |
| MECP2 regulates transcription of neuronal ligands | R-HSA-9022702 | 2.871955e-01 | 0.542 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 2.871955e-01 | 0.542 | 0 | 0 |
| Folding of actin by CCT/TriC | R-HSA-390450 | 2.871955e-01 | 0.542 | 0 | 0 |
| Assembly and release of respiratory syncytial virus (RSV) virions | R-HSA-9820962 | 2.871955e-01 | 0.542 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 2.907656e-01 | 0.536 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 2.907656e-01 | 0.536 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 2.907656e-01 | 0.536 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 2.923713e-01 | 0.534 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 2.926626e-01 | 0.534 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 2.926626e-01 | 0.534 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 2.926626e-01 | 0.534 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 2.936937e-01 | 0.532 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 2.960362e-01 | 0.529 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 2.965790e-01 | 0.528 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 2.969665e-01 | 0.527 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 2.988951e-01 | 0.524 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 3.005048e-01 | 0.522 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 3.032559e-01 | 0.518 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 3.032559e-01 | 0.518 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 3.032559e-01 | 0.518 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 3.083682e-01 | 0.511 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 3.083682e-01 | 0.511 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 3.083682e-01 | 0.511 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 3.087608e-01 | 0.510 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 3.087608e-01 | 0.510 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 3.099474e-01 | 0.509 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 3.100697e-01 | 0.509 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 3.100697e-01 | 0.509 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 3.128620e-01 | 0.505 | 0 | 0 |
| Formation of the posterior neural plate | R-HSA-9832991 | 3.171172e-01 | 0.499 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 3.171172e-01 | 0.499 | 0 | 0 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | 3.171172e-01 | 0.499 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 3.194013e-01 | 0.496 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 3.195246e-01 | 0.495 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 3.206512e-01 | 0.494 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 3.206512e-01 | 0.494 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 3.214783e-01 | 0.493 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 3.241880e-01 | 0.489 | 0 | 0 |
| RAS processing | R-HSA-9648002 | 3.241880e-01 | 0.489 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 3.241880e-01 | 0.489 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 3.242111e-01 | 0.489 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 3.313744e-01 | 0.480 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 3.349960e-01 | 0.475 | 0 | 0 |
| Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | R-HSA-9944997 | 3.354751e-01 | 0.474 | 0 | 0 |
| MET activates PTPN11 | R-HSA-8865999 | 3.354751e-01 | 0.474 | 0 | 0 |
| Loss of Function of KMT2D in Kabuki Syndrome | R-HSA-9944971 | 3.354751e-01 | 0.474 | 0 | 0 |
| MET interacts with TNS proteins | R-HSA-8875513 | 3.354751e-01 | 0.474 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 3.354751e-01 | 0.474 | 0 | 0 |
| Intracellular oxygen transport | R-HSA-8981607 | 3.354751e-01 | 0.474 | 0 | 0 |
| Diseases of Mismatch Repair (MMR) | R-HSA-5423599 | 3.354751e-01 | 0.474 | 0 | 0 |
| PI3K Cascade | R-HSA-109704 | 3.384388e-01 | 0.471 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 3.397751e-01 | 0.469 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 3.397751e-01 | 0.469 | 0 | 0 |
| NOTCH3 Intracellular Domain Regulates Transcription | R-HSA-9013508 | 3.397751e-01 | 0.469 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 3.400922e-01 | 0.468 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 3.400922e-01 | 0.468 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 3.400922e-01 | 0.468 | 0 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 3.417132e-01 | 0.466 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 3.467359e-01 | 0.460 | 0 | 0 |
| Sensing of DNA Double Strand Breaks | R-HSA-5693548 | 3.467359e-01 | 0.460 | 0 | 0 |
| POLB-Dependent Long Patch Base Excision Repair | R-HSA-110362 | 3.467359e-01 | 0.460 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperone genes | R-HSA-381183 | 3.467359e-01 | 0.460 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 3.518082e-01 | 0.454 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 3.560516e-01 | 0.448 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 3.570937e-01 | 0.447 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 3.581027e-01 | 0.446 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 3.581027e-01 | 0.446 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 3.581027e-01 | 0.446 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 3.619223e-01 | 0.441 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 3.619223e-01 | 0.441 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 3.630362e-01 | 0.440 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 3.630362e-01 | 0.440 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 3.686760e-01 | 0.433 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 3.720378e-01 | 0.429 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 3.744193e-01 | 0.427 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 3.759150e-01 | 0.425 | 0 | 0 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | 3.759150e-01 | 0.425 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 3.759150e-01 | 0.425 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 3.759150e-01 | 0.425 | 0 | 0 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | 3.759150e-01 | 0.425 | 0 | 0 |
| Regulation of FOXO transcriptional activity by acetylation | R-HSA-9617629 | 3.759150e-01 | 0.425 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 3.759150e-01 | 0.425 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 3.764198e-01 | 0.424 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 3.814299e-01 | 0.419 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 3.855187e-01 | 0.414 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 3.855187e-01 | 0.414 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 3.858317e-01 | 0.414 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 3.869936e-01 | 0.412 | 0 | 0 |
| Defective LFNG causes SCDO3 | R-HSA-5083630 | 3.876399e-01 | 0.412 | 0 | 0 |
| Regulation of gap junction activity | R-HSA-191650 | 3.876399e-01 | 0.412 | 0 | 0 |
| Transcriptional activation of cell cycle inhibitor p21 | R-HSA-69895 | 3.876399e-01 | 0.412 | 0 | 0 |
| Transcriptional activation of p53 responsive genes | R-HSA-69560 | 3.876399e-01 | 0.412 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 3.876399e-01 | 0.412 | 0 | 0 |
| Activation of NOXA and translocation to mitochondria | R-HSA-111448 | 3.876399e-01 | 0.412 | 0 | 0 |
| NADE modulates death signalling | R-HSA-205025 | 3.876399e-01 | 0.412 | 0 | 0 |
| Sensory perception of sour taste | R-HSA-9729555 | 3.876399e-01 | 0.412 | 0 | 0 |
| FLT3 signaling through SRC family kinases | R-HSA-9706374 | 3.876399e-01 | 0.412 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 3.880236e-01 | 0.411 | 0 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 3.927217e-01 | 0.406 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 3.946873e-01 | 0.404 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 3.946873e-01 | 0.404 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 3.946873e-01 | 0.404 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 4.007794e-01 | 0.397 | 0 | 0 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | R-HSA-6803205 | 4.009146e-01 | 0.397 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 4.029717e-01 | 0.395 | 0 | 0 |
| Immune System | R-HSA-168256 | 4.037242e-01 | 0.394 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 4.039829e-01 | 0.394 | 0 | 0 |
| PDH complex synthesizes acetyl-CoA from PYR | R-HSA-9861559 | 4.045410e-01 | 0.393 | 0 | 0 |
| Golgi Cisternae Pericentriolar Stack Reorganization | R-HSA-162658 | 4.045410e-01 | 0.393 | 0 | 0 |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | 4.045410e-01 | 0.393 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9683610 | 4.045410e-01 | 0.393 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperones | R-HSA-381033 | 4.045410e-01 | 0.393 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 4.050666e-01 | 0.392 | 0 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 4.050666e-01 | 0.392 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 4.128685e-01 | 0.384 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 4.198906e-01 | 0.377 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 4.198906e-01 | 0.377 | 0 | 0 |
| G1 Phase | R-HSA-69236 | 4.198906e-01 | 0.377 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 4.220241e-01 | 0.375 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE | R-HSA-77075 | 4.225197e-01 | 0.374 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | R-HSA-167160 | 4.225197e-01 | 0.374 | 0 | 0 |
| Interleukin receptor SHC signaling | R-HSA-912526 | 4.225197e-01 | 0.374 | 0 | 0 |
| Response of EIF2AK1 (HRI) to heme deficiency | R-HSA-9648895 | 4.225197e-01 | 0.374 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 4.225197e-01 | 0.374 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 4.225197e-01 | 0.374 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 4.225197e-01 | 0.374 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 4.244649e-01 | 0.372 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 4.276299e-01 | 0.369 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 4.276299e-01 | 0.369 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 4.309288e-01 | 0.366 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 4.325212e-01 | 0.364 | 0 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 4.325212e-01 | 0.364 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 4.328217e-01 | 0.364 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 4.344508e-01 | 0.362 | 0 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 4.344508e-01 | 0.362 | 0 | 0 |
| IRS activation | R-HSA-74713 | 4.357127e-01 | 0.361 | 0 | 0 |
| IRF3 mediated activation of type 1 IFN | R-HSA-1606341 | 4.357127e-01 | 0.361 | 0 | 0 |
| Resolution of AP sites via the single-nucleotide replacement pathway | R-HSA-110381 | 4.357127e-01 | 0.361 | 0 | 0 |
| Activation of AKT2 | R-HSA-165158 | 4.357127e-01 | 0.361 | 0 | 0 |
| Reelin signalling pathway | R-HSA-8866376 | 4.357127e-01 | 0.361 | 0 | 0 |
| Nectin/Necl trans heterodimerization | R-HSA-420597 | 4.357127e-01 | 0.361 | 0 | 0 |
| Interleukin-36 pathway | R-HSA-9014826 | 4.357127e-01 | 0.361 | 0 | 0 |
| NrCAM interactions | R-HSA-447038 | 4.357127e-01 | 0.361 | 0 | 0 |
| Co-inhibition by BTLA | R-HSA-9927353 | 4.357127e-01 | 0.361 | 0 | 0 |
| Assembly of Viral Components at the Budding Site | R-HSA-168316 | 4.357127e-01 | 0.361 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 4.357146e-01 | 0.361 | 1 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 4.357230e-01 | 0.361 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 4.387323e-01 | 0.358 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 4.429875e-01 | 0.354 | 0 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 4.438522e-01 | 0.353 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 4.438522e-01 | 0.353 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 4.438522e-01 | 0.353 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 4.440037e-01 | 0.353 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 4.488361e-01 | 0.348 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 4.514575e-01 | 0.345 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 4.537627e-01 | 0.343 | 0 | 0 |
| Protein folding | R-HSA-391251 | 4.543712e-01 | 0.343 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 4.597805e-01 | 0.337 | 0 | 0 |
| Formation of the anterior neural plate | R-HSA-9823739 | 4.597805e-01 | 0.337 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 4.648668e-01 | 0.333 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 4.648668e-01 | 0.333 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 4.648668e-01 | 0.333 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 4.648668e-01 | 0.333 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 4.657179e-01 | 0.332 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 4.662779e-01 | 0.331 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 4.665608e-01 | 0.331 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 4.670479e-01 | 0.331 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 4.670479e-01 | 0.331 | 0 | 0 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 4.800141e-01 | 0.319 | 0 | 0 |
| SLIT2:ROBO1 increases RHOA activity | R-HSA-8985586 | 4.800141e-01 | 0.319 | 0 | 0 |
| Signaling by RNF43 mutants | R-HSA-5340588 | 4.800141e-01 | 0.319 | 0 | 0 |
| GLI proteins bind promoters of Hh responsive genes to promote transcription | R-HSA-5635851 | 4.800141e-01 | 0.319 | 0 | 0 |
| PKA-mediated phosphorylation of key metabolic factors | R-HSA-163358 | 4.800141e-01 | 0.319 | 0 | 0 |
| Aryl hydrocarbon receptor signalling | R-HSA-8937144 | 4.800141e-01 | 0.319 | 0 | 0 |
| Cam-PDE 1 activation | R-HSA-111957 | 4.800141e-01 | 0.319 | 0 | 0 |
| Phosphorylation of Emi1 | R-HSA-176417 | 4.800141e-01 | 0.319 | 0 | 0 |
| Signalling to p38 via RIT and RIN | R-HSA-187706 | 4.800141e-01 | 0.319 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 4.800141e-01 | 0.319 | 0 | 0 |
| Epithelial-Mesenchymal Transition (EMT) during gastrulation | R-HSA-9758919 | 4.800141e-01 | 0.319 | 0 | 0 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | 4.800141e-01 | 0.319 | 0 | 0 |
| SLC15A4:TASL-dependent IRF5 activation | R-HSA-9860276 | 4.800141e-01 | 0.319 | 0 | 0 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 4.840755e-01 | 0.315 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 4.855238e-01 | 0.314 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 4.855238e-01 | 0.314 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 4.862598e-01 | 0.313 | 0 | 0 |
| Class I peroxisomal membrane protein import | R-HSA-9603798 | 4.862598e-01 | 0.313 | 0 | 0 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | R-HSA-210744 | 4.862598e-01 | 0.313 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 4.892689e-01 | 0.310 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 4.949670e-01 | 0.305 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 4.949670e-01 | 0.305 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 4.949670e-01 | 0.305 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 5.013552e-01 | 0.300 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 5.013552e-01 | 0.300 | 0 | 0 |
| Signaling by BMP | R-HSA-201451 | 5.057883e-01 | 0.296 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 5.087417e-01 | 0.294 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 5.105685e-01 | 0.292 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 5.110232e-01 | 0.292 | 0 | 0 |
| G beta:gamma signalling through CDC42 | R-HSA-8964616 | 5.119135e-01 | 0.291 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 5.119135e-01 | 0.291 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 5.119135e-01 | 0.291 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 5.119135e-01 | 0.291 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 5.119135e-01 | 0.291 | 0 | 0 |
| Coenzyme A biosynthesis | R-HSA-196783 | 5.119135e-01 | 0.291 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 5.180709e-01 | 0.286 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 5.183771e-01 | 0.285 | 0 | 0 |
| Signaling by LTK in cancer | R-HSA-9842640 | 5.208400e-01 | 0.283 | 0 | 0 |
| STAT5 Activation | R-HSA-9645135 | 5.208400e-01 | 0.283 | 0 | 0 |
| RUNX3 regulates YAP1-mediated transcription | R-HSA-8951671 | 5.208400e-01 | 0.283 | 0 | 0 |
| Autointegration results in viral DNA circles | R-HSA-177539 | 5.208400e-01 | 0.283 | 0 | 0 |
| G2/M DNA replication checkpoint | R-HSA-69478 | 5.208400e-01 | 0.283 | 0 | 0 |
| E2F-enabled inhibition of pre-replication complex formation | R-HSA-113507 | 5.208400e-01 | 0.283 | 0 | 0 |
| RAS signaling downstream of NF1 loss-of-function variants | R-HSA-6802953 | 5.208400e-01 | 0.283 | 0 | 0 |
| Neurofascin interactions | R-HSA-447043 | 5.208400e-01 | 0.283 | 0 | 0 |
| Integration of viral DNA into host genomic DNA | R-HSA-175567 | 5.208400e-01 | 0.283 | 0 | 0 |
| Lactose synthesis | R-HSA-5653890 | 5.208400e-01 | 0.283 | 0 | 0 |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | R-HSA-2980767 | 5.208400e-01 | 0.283 | 0 | 0 |
| NADPH regeneration | R-HSA-389542 | 5.208400e-01 | 0.283 | 0 | 0 |
| VLDL assembly | R-HSA-8866423 | 5.208400e-01 | 0.283 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 5.256299e-01 | 0.279 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 5.256299e-01 | 0.279 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 5.256299e-01 | 0.279 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 5.256299e-01 | 0.279 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 5.277283e-01 | 0.278 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 5.279595e-01 | 0.277 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 5.351207e-01 | 0.272 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 5.351207e-01 | 0.272 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 5.351207e-01 | 0.272 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 5.358567e-01 | 0.271 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 5.358567e-01 | 0.271 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 5.367081e-01 | 0.270 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 5.367081e-01 | 0.270 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 5.367081e-01 | 0.270 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 5.367081e-01 | 0.270 | 0 | 0 |
| Synthesis of PIPs at the late endosome membrane | R-HSA-1660517 | 5.367081e-01 | 0.270 | 0 | 0 |
| Modulation of host responses by IFN-stimulated genes | R-HSA-9909505 | 5.367081e-01 | 0.270 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 5.367081e-01 | 0.270 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 5.404671e-01 | 0.267 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 5.426681e-01 | 0.265 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 5.427037e-01 | 0.265 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 5.450229e-01 | 0.264 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 5.450229e-01 | 0.264 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 5.485116e-01 | 0.261 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 5.491733e-01 | 0.260 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 5.498130e-01 | 0.260 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 5.515677e-01 | 0.258 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 5.515677e-01 | 0.258 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 5.572276e-01 | 0.254 | 0 | 0 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | 5.584627e-01 | 0.253 | 0 | 0 |
| Defective HLCS causes multiple carboxylase deficiency | R-HSA-3371599 | 5.584627e-01 | 0.253 | 0 | 0 |
| IFNG signaling activates MAPKs | R-HSA-9732724 | 5.584627e-01 | 0.253 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 5.584627e-01 | 0.253 | 0 | 0 |
| Pre-NOTCH Processing in the Endoplasmic Reticulum | R-HSA-1912399 | 5.584627e-01 | 0.253 | 0 | 0 |
| Activated NTRK2 signals through CDK5 | R-HSA-9032845 | 5.584627e-01 | 0.253 | 0 | 0 |
| NOSTRIN mediated eNOS trafficking | R-HSA-203641 | 5.584627e-01 | 0.253 | 0 | 0 |
| Activation of PUMA and translocation to mitochondria | R-HSA-139915 | 5.584627e-01 | 0.253 | 0 | 0 |
| LDL remodeling | R-HSA-8964041 | 5.584627e-01 | 0.253 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 5.606204e-01 | 0.251 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 5.606204e-01 | 0.251 | 0 | 0 |
| Polo-like kinase mediated events | R-HSA-156711 | 5.606204e-01 | 0.251 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 5.606204e-01 | 0.251 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 5.606204e-01 | 0.251 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 5.606204e-01 | 0.251 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 5.606204e-01 | 0.251 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 5.606204e-01 | 0.251 | 0 | 0 |
| FOXO-mediated transcription of cell death genes | R-HSA-9614657 | 5.606204e-01 | 0.251 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 5.606204e-01 | 0.251 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 5.639453e-01 | 0.249 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 5.639453e-01 | 0.249 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 5.639453e-01 | 0.249 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 5.677016e-01 | 0.246 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 5.823792e-01 | 0.235 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 5.836360e-01 | 0.234 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 5.836360e-01 | 0.234 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 5.906894e-01 | 0.229 | 0 | 0 |
| phospho-PLA2 pathway | R-HSA-111995 | 5.931335e-01 | 0.227 | 0 | 0 |
| Activated NTRK2 signals through PI3K | R-HSA-9028335 | 5.931335e-01 | 0.227 | 0 | 0 |
| MET receptor recycling | R-HSA-8875656 | 5.931335e-01 | 0.227 | 0 | 0 |
| Formyl peptide receptors bind formyl peptides and many other ligands | R-HSA-444473 | 5.931335e-01 | 0.227 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | R-HSA-8939246 | 5.931335e-01 | 0.227 | 0 | 0 |
| Neurotransmitter uptake and metabolism In glial cells | R-HSA-112313 | 5.931335e-01 | 0.227 | 0 | 0 |
| Astrocytic Glutamate-Glutamine Uptake And Metabolism | R-HSA-210455 | 5.931335e-01 | 0.227 | 0 | 0 |
| Sodium/Proton exchangers | R-HSA-425986 | 5.931335e-01 | 0.227 | 0 | 0 |
| Interleukin-23 signaling | R-HSA-9020933 | 5.931335e-01 | 0.227 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 5.934209e-01 | 0.227 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 5.954281e-01 | 0.225 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 5.989754e-01 | 0.223 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 6.041566e-01 | 0.219 | 1 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 6.057483e-01 | 0.218 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 6.057483e-01 | 0.218 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 6.057483e-01 | 0.218 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 6.057483e-01 | 0.218 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 6.057483e-01 | 0.218 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 6.177271e-01 | 0.209 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 6.177271e-01 | 0.209 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 6.177271e-01 | 0.209 | 0 | 0 |
| Estrogen-stimulated signaling through PRKCZ | R-HSA-9634635 | 6.250837e-01 | 0.204 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 6.250837e-01 | 0.204 | 0 | 0 |
| AMPK inhibits chREBP transcriptional activation activity | R-HSA-163680 | 6.250837e-01 | 0.204 | 0 | 0 |
| Defects in biotin (Btn) metabolism | R-HSA-3323169 | 6.250837e-01 | 0.204 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 6.250837e-01 | 0.204 | 0 | 0 |
| APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway | R-HSA-5649702 | 6.250837e-01 | 0.204 | 0 | 0 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | 6.250837e-01 | 0.204 | 0 | 0 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | R-HSA-428542 | 6.250837e-01 | 0.204 | 0 | 0 |
| Regulation of signaling by NODAL | R-HSA-1433617 | 6.250837e-01 | 0.204 | 0 | 0 |
| MASTL Facilitates Mitotic Progression | R-HSA-2465910 | 6.250837e-01 | 0.204 | 0 | 0 |
| Interleukin-1 processing | R-HSA-448706 | 6.250837e-01 | 0.204 | 0 | 0 |
| Zinc influx into cells by the SLC39 gene family | R-HSA-442380 | 6.250837e-01 | 0.204 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 6.250837e-01 | 0.204 | 0 | 0 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 6.269573e-01 | 0.203 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 12 | R-HSA-392170 | 6.269573e-01 | 0.203 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 6.269573e-01 | 0.203 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 6.288499e-01 | 0.201 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 6.303630e-01 | 0.200 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 6.303630e-01 | 0.200 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 6.303630e-01 | 0.200 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 6.346217e-01 | 0.197 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 6.346217e-01 | 0.197 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 6.346217e-01 | 0.197 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 6.369984e-01 | 0.196 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 6.369984e-01 | 0.196 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 6.432413e-01 | 0.192 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 6.472685e-01 | 0.189 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 6.472685e-01 | 0.189 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 6.472685e-01 | 0.189 | 0 | 0 |
| FOXO-mediated transcription of cell cycle genes | R-HSA-9617828 | 6.472685e-01 | 0.189 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 6.486852e-01 | 0.188 | 0 | 0 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | R-HSA-6814122 | 6.509887e-01 | 0.186 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 6.509887e-01 | 0.186 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 6.509887e-01 | 0.186 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 6.509887e-01 | 0.186 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 6.509887e-01 | 0.186 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 6.516126e-01 | 0.186 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 6.518344e-01 | 0.186 | 0 | 0 |
| Activation of Ca-permeable Kainate Receptor | R-HSA-451308 | 6.545267e-01 | 0.184 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 6.545267e-01 | 0.184 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 6.545267e-01 | 0.184 | 0 | 0 |
| Binding and entry of HIV virion | R-HSA-173107 | 6.545267e-01 | 0.184 | 0 | 0 |
| Ion influx/efflux at host-pathogen interface | R-HSA-6803544 | 6.545267e-01 | 0.184 | 0 | 0 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | R-HSA-2151209 | 6.545267e-01 | 0.184 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 6.545267e-01 | 0.184 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 6.545267e-01 | 0.184 | 0 | 0 |
| CASP4 inflammasome assembly | R-HSA-9948001 | 6.545267e-01 | 0.184 | 0 | 0 |
| MAPK3 (ERK1) activation | R-HSA-110056 | 6.545267e-01 | 0.184 | 0 | 0 |
| Interleukin-27 signaling | R-HSA-9020956 | 6.545267e-01 | 0.184 | 0 | 0 |
| Maturation of spike protein | R-HSA-9683686 | 6.545267e-01 | 0.184 | 0 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 6.545267e-01 | 0.184 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 6.642463e-01 | 0.178 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 6.666920e-01 | 0.176 | 0 | 0 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | R-HSA-9670439 | 6.666920e-01 | 0.176 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 6.666920e-01 | 0.176 | 0 | 0 |
| Signaling by KIT in disease | R-HSA-9669938 | 6.666920e-01 | 0.176 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy | R-HSA-9857377 | 6.666920e-01 | 0.176 | 0 | 0 |
| Neurotoxicity of clostridium toxins | R-HSA-168799 | 6.666920e-01 | 0.176 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 6.668250e-01 | 0.176 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 6.668250e-01 | 0.176 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 6.668250e-01 | 0.176 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 6.713596e-01 | 0.173 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 6.816590e-01 | 0.166 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 6.816590e-01 | 0.166 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 6.816590e-01 | 0.166 | 0 | 0 |
| Ionotropic activity of kainate receptors | R-HSA-451306 | 6.816590e-01 | 0.166 | 0 | 0 |
| vRNP Assembly | R-HSA-192905 | 6.816590e-01 | 0.166 | 0 | 0 |
| vRNA Synthesis | R-HSA-192814 | 6.816590e-01 | 0.166 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 6.816590e-01 | 0.166 | 0 | 0 |
| Chylomicron assembly | R-HSA-8963888 | 6.816590e-01 | 0.166 | 0 | 0 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 6.816590e-01 | 0.166 | 0 | 0 |
| Suppression of apoptosis | R-HSA-9635465 | 6.816590e-01 | 0.166 | 0 | 0 |
| CD163 mediating an anti-inflammatory response | R-HSA-9662834 | 6.816590e-01 | 0.166 | 0 | 0 |
| Interleukin-2 signaling | R-HSA-9020558 | 6.816590e-01 | 0.166 | 0 | 0 |
| Dissolution of Fibrin Clot | R-HSA-75205 | 6.816590e-01 | 0.166 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 6.821301e-01 | 0.166 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 6.821301e-01 | 0.166 | 0 | 0 |
| Glycosphingolipid transport | R-HSA-9845576 | 6.821301e-01 | 0.166 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 6.821301e-01 | 0.166 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 6.821301e-01 | 0.166 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 6.829427e-01 | 0.166 | 0 | 0 |
| Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 6.852420e-01 | 0.164 | 0 | 0 |
| Carnitine shuttle | R-HSA-200425 | 6.852420e-01 | 0.164 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 6.852420e-01 | 0.164 | 0 | 0 |
| Azathioprine ADME | R-HSA-9748787 | 6.970510e-01 | 0.157 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 6.970510e-01 | 0.157 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 6.983432e-01 | 0.156 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 7.029025e-01 | 0.153 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 1 | R-HSA-418592 | 7.029358e-01 | 0.153 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 7.029358e-01 | 0.153 | 0 | 0 |
| Mitochondrial RNA degradation | R-HSA-9836573 | 7.029358e-01 | 0.153 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 7.029358e-01 | 0.153 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 7.035739e-01 | 0.153 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 7.035739e-01 | 0.153 | 0 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 7.044273e-01 | 0.152 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 7.049725e-01 | 0.152 | 1 | 0 |
| Synthesis of diphthamide-EEF2 | R-HSA-5358493 | 7.066620e-01 | 0.151 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 7.066620e-01 | 0.151 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 7.066620e-01 | 0.151 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 7.066620e-01 | 0.151 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | R-HSA-9623433 | 7.066620e-01 | 0.151 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 7.066620e-01 | 0.151 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 7.066620e-01 | 0.151 | 0 | 0 |
| Viral RNP Complexes in the Host Cell Nucleus | R-HSA-168330 | 7.066620e-01 | 0.151 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 7.066620e-01 | 0.151 | 0 | 0 |
| Sodium/Calcium exchangers | R-HSA-425561 | 7.066620e-01 | 0.151 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 7.111537e-01 | 0.148 | 0 | 0 |
| Synthesis of PIPs at the early endosome membrane | R-HSA-1660516 | 7.197935e-01 | 0.143 | 0 | 0 |
| Laminin interactions | R-HSA-3000157 | 7.197935e-01 | 0.143 | 0 | 0 |
| Glycogen breakdown (glycogenolysis) | R-HSA-70221 | 7.197935e-01 | 0.143 | 0 | 0 |
| PIWI-interacting RNA (piRNA) biogenesis | R-HSA-5601884 | 7.197935e-01 | 0.143 | 0 | 0 |
| Formation of the nephric duct | R-HSA-9830364 | 7.197935e-01 | 0.143 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 7.248802e-01 | 0.140 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 7.265690e-01 | 0.139 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 7.267324e-01 | 0.139 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 7.297026e-01 | 0.137 | 0 | 0 |
| Defective EXT2 causes exostoses 2 | R-HSA-3656237 | 7.297026e-01 | 0.137 | 0 | 0 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | R-HSA-3656253 | 7.297026e-01 | 0.137 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 7.297026e-01 | 0.137 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 7.297026e-01 | 0.137 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 7.297026e-01 | 0.137 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 7.297026e-01 | 0.137 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 7.297026e-01 | 0.137 | 0 | 0 |
| Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | R-HSA-9931530 | 7.297026e-01 | 0.137 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 7.297026e-01 | 0.137 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 7.297026e-01 | 0.137 | 0 | 0 |
| Advanced glycosylation endproduct receptor signaling | R-HSA-879415 | 7.297026e-01 | 0.137 | 0 | 0 |
| Serotonin clearance from the synaptic cleft | R-HSA-380615 | 7.297026e-01 | 0.137 | 0 | 0 |
| Trafficking and processing of endosomal TLR | R-HSA-1679131 | 7.297026e-01 | 0.137 | 0 | 0 |
| Regulation of IFNG signaling | R-HSA-877312 | 7.297026e-01 | 0.137 | 0 | 0 |
| Interleukin-15 signaling | R-HSA-8983432 | 7.297026e-01 | 0.137 | 0 | 0 |
| Interleukin-35 Signalling | R-HSA-8984722 | 7.297026e-01 | 0.137 | 0 | 0 |
| Reversal of alkylation damage by DNA dioxygenases | R-HSA-73943 | 7.297026e-01 | 0.137 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 7.302779e-01 | 0.137 | 0 | 0 |
| Disease | R-HSA-1643685 | 7.344125e-01 | 0.134 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 7.347251e-01 | 0.134 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 7.358373e-01 | 0.133 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 7.358373e-01 | 0.133 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 7.358373e-01 | 0.133 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 7.358373e-01 | 0.133 | 0 | 0 |
| Sphingolipid catabolism | R-HSA-9845614 | 7.358373e-01 | 0.133 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 7.358373e-01 | 0.133 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 7.391746e-01 | 0.131 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 7.454229e-01 | 0.128 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 7.469006e-01 | 0.127 | 0 | 0 |
| Microbial factors inhibit CASP4 activity | R-HSA-9956593 | 7.509347e-01 | 0.124 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 7.509347e-01 | 0.124 | 0 | 0 |
| Platelet Adhesion to exposed collagen | R-HSA-75892 | 7.509347e-01 | 0.124 | 0 | 0 |
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | R-HSA-5676594 | 7.509347e-01 | 0.124 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 7.509347e-01 | 0.124 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 7.510909e-01 | 0.124 | 0 | 0 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 7.510909e-01 | 0.124 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 7.629975e-01 | 0.117 | 0 | 0 |
| Insulin receptor recycling | R-HSA-77387 | 7.655795e-01 | 0.116 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 7.655795e-01 | 0.116 | 0 | 0 |
| ATF4 activates genes in response to endoplasmic reticulum stress | R-HSA-380994 | 7.655795e-01 | 0.116 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 7.655795e-01 | 0.116 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 7.698468e-01 | 0.114 | 0 | 0 |
| TP53 Regulates Transcription of Death Receptors and Ligands | R-HSA-6803211 | 7.705002e-01 | 0.113 | 0 | 0 |
| CLEC7A (Dectin-1) induces NFAT activation | R-HSA-5607763 | 7.705002e-01 | 0.113 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 7.705002e-01 | 0.113 | 0 | 0 |
| Hydrolysis of LPC | R-HSA-1483115 | 7.705002e-01 | 0.113 | 0 | 0 |
| Signaling by FGFR4 in disease | R-HSA-5655291 | 7.705002e-01 | 0.113 | 0 | 0 |
| Physiological factors | R-HSA-5578768 | 7.705002e-01 | 0.113 | 0 | 0 |
| Respiratory syncytial virus genome transcription | R-HSA-9828642 | 7.705002e-01 | 0.113 | 0 | 0 |
| Non-canonical inflammasome activation | R-HSA-9686114 | 7.705002e-01 | 0.113 | 0 | 0 |
| HDL assembly | R-HSA-8963896 | 7.705002e-01 | 0.113 | 0 | 0 |
| Acyl chain remodeling of CL | R-HSA-1482798 | 7.705002e-01 | 0.113 | 0 | 0 |
| Zinc transporters | R-HSA-435354 | 7.705002e-01 | 0.113 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 7.747112e-01 | 0.111 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 7.786867e-01 | 0.109 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 7.793290e-01 | 0.108 | 0 | 0 |
| Regulation of pyruvate dehydrogenase (PDH) complex | R-HSA-204174 | 7.793290e-01 | 0.108 | 0 | 0 |
| Glucagon-type ligand receptors | R-HSA-420092 | 7.793290e-01 | 0.108 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 7.793290e-01 | 0.108 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 7.859455e-01 | 0.105 | 0 | 0 |
| Adenylate cyclase inhibitory pathway | R-HSA-170670 | 7.885297e-01 | 0.103 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 7.885297e-01 | 0.103 | 0 | 0 |
| G beta:gamma signalling through BTK | R-HSA-8964315 | 7.885297e-01 | 0.103 | 0 | 0 |
| Telomere C-strand synthesis initiation | R-HSA-174430 | 7.885297e-01 | 0.103 | 0 | 0 |
| Biotin transport and metabolism | R-HSA-196780 | 7.885297e-01 | 0.103 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 7.885297e-01 | 0.103 | 0 | 0 |
| STAT3 nuclear events downstream of ALK signaling | R-HSA-9701898 | 7.885297e-01 | 0.103 | 0 | 0 |
| DNA Damage Reversal | R-HSA-73942 | 7.885297e-01 | 0.103 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 7.889576e-01 | 0.103 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 7.901048e-01 | 0.102 | 0 | 0 |
| DAP12 signaling | R-HSA-2424491 | 7.923663e-01 | 0.101 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 7.923663e-01 | 0.101 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 7.923663e-01 | 0.101 | 0 | 0 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 7.923663e-01 | 0.101 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 7.923663e-01 | 0.101 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 7.923663e-01 | 0.101 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 7.952783e-01 | 0.099 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 7.952783e-01 | 0.099 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 7.961002e-01 | 0.099 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 7.961002e-01 | 0.099 | 0 | 0 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 8.047182e-01 | 0.094 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 8.047182e-01 | 0.094 | 0 | 0 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | R-HSA-6803207 | 8.051439e-01 | 0.094 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 8.051439e-01 | 0.094 | 0 | 0 |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | R-HSA-434316 | 8.051439e-01 | 0.094 | 0 | 0 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | R-HSA-9634600 | 8.051439e-01 | 0.094 | 0 | 0 |
| Activation of SMO | R-HSA-5635838 | 8.051439e-01 | 0.094 | 0 | 0 |
| Attachment and Entry | R-HSA-9678110 | 8.051439e-01 | 0.094 | 0 | 0 |
| Virus Assembly and Release | R-HSA-168268 | 8.051439e-01 | 0.094 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 8.164120e-01 | 0.088 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 8.164120e-01 | 0.088 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 8.168859e-01 | 0.088 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 8.177718e-01 | 0.087 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 8.185324e-01 | 0.087 | 0 | 0 |
| Antigen processing: Ub, ATP-independent proteasomal degradation | R-HSA-9912633 | 8.204537e-01 | 0.086 | 0 | 0 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | R-HSA-4420332 | 8.204537e-01 | 0.086 | 0 | 0 |
| Defective B4GALT7 causes EDS, progeroid type | R-HSA-3560783 | 8.204537e-01 | 0.086 | 0 | 0 |
| Transcriptional regulation of testis differentiation | R-HSA-9690406 | 8.204537e-01 | 0.086 | 0 | 0 |
| STAT5 activation downstream of FLT3 ITD mutants | R-HSA-9702518 | 8.204537e-01 | 0.086 | 0 | 0 |
| Passive transport by Aquaporins | R-HSA-432047 | 8.204537e-01 | 0.086 | 0 | 0 |
| tRNA modification in the mitochondrion | R-HSA-6787450 | 8.204537e-01 | 0.086 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 8.204537e-01 | 0.086 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 8.226822e-01 | 0.085 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 8.226822e-01 | 0.085 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 8.274748e-01 | 0.082 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 8.274748e-01 | 0.082 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 8.308814e-01 | 0.080 | 0 | 0 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 8.345614e-01 | 0.079 | 0 | 0 |
| Defective B3GAT3 causes JDSSDHD | R-HSA-3560801 | 8.345614e-01 | 0.079 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 8.345614e-01 | 0.079 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 8.345614e-01 | 0.079 | 0 | 0 |
| Choline catabolism | R-HSA-6798163 | 8.345614e-01 | 0.079 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 8.345614e-01 | 0.079 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 8.353329e-01 | 0.078 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 8.379335e-01 | 0.077 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 8.379335e-01 | 0.077 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 8.379335e-01 | 0.077 | 0 | 0 |
| Vitamin B5 (pantothenate) metabolism | R-HSA-199220 | 8.379335e-01 | 0.077 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 8.384809e-01 | 0.077 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 8.439407e-01 | 0.074 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 8.446033e-01 | 0.073 | 0 | 0 |
| Cytosolic iron-sulfur cluster assembly | R-HSA-2564830 | 8.475614e-01 | 0.072 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 8.475614e-01 | 0.072 | 0 | 0 |
| Organic anion transport by SLC5/17/25 transporters | R-HSA-428643 | 8.475614e-01 | 0.072 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9679504 | 8.475614e-01 | 0.072 | 0 | 0 |
| Regulation of TLR by endogenous ligand | R-HSA-5686938 | 8.478147e-01 | 0.072 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 8.478147e-01 | 0.072 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 8.512011e-01 | 0.070 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 8.595406e-01 | 0.066 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 8.595406e-01 | 0.066 | 0 | 0 |
| Prostacyclin signalling through prostacyclin receptor | R-HSA-392851 | 8.595406e-01 | 0.066 | 0 | 0 |
| mRNA decay by 3' to 5' exoribonuclease | R-HSA-429958 | 8.595406e-01 | 0.066 | 0 | 0 |
| E2F mediated regulation of DNA replication | R-HSA-113510 | 8.595406e-01 | 0.066 | 0 | 0 |
| Other interleukin signaling | R-HSA-449836 | 8.595406e-01 | 0.066 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 8.599904e-01 | 0.066 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 8.605760e-01 | 0.065 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 8.639974e-01 | 0.063 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 8.662696e-01 | 0.062 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 8.701061e-01 | 0.060 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 8.705791e-01 | 0.060 | 0 | 0 |
| Formation of ATP by chemiosmotic coupling | R-HSA-163210 | 8.705791e-01 | 0.060 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 8.705791e-01 | 0.060 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 8.705791e-01 | 0.060 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 8.705791e-01 | 0.060 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 8.705791e-01 | 0.060 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 8.705791e-01 | 0.060 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 8.705791e-01 | 0.060 | 0 | 0 |
| Acyl chain remodelling of PI | R-HSA-1482922 | 8.705791e-01 | 0.060 | 0 | 0 |
| Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 8.705791e-01 | 0.060 | 0 | 0 |
| Pregnenolone biosynthesis | R-HSA-196108 | 8.705791e-01 | 0.060 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 8.749354e-01 | 0.058 | 0 | 0 |
| G-protein activation | R-HSA-202040 | 8.807507e-01 | 0.055 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 8.807507e-01 | 0.055 | 0 | 0 |
| Synthesis, secretion, and deacylation of Ghrelin | R-HSA-422085 | 8.807507e-01 | 0.055 | 0 | 0 |
| Vitamin C (ascorbate) metabolism | R-HSA-196836 | 8.807507e-01 | 0.055 | 0 | 0 |
| Acyl chain remodelling of PG | R-HSA-1482925 | 8.807507e-01 | 0.055 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 8.820793e-01 | 0.054 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 8.856977e-01 | 0.053 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 8.867355e-01 | 0.052 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 8.877935e-01 | 0.052 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 8.877935e-01 | 0.052 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 8.885449e-01 | 0.051 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 8.894534e-01 | 0.051 | 0 | 0 |
| Serine metabolism | R-HSA-977347 | 8.901234e-01 | 0.051 | 0 | 0 |
| Metabolism of Angiotensinogen to Angiotensins | R-HSA-2022377 | 8.901234e-01 | 0.051 | 0 | 0 |
| Ribavirin ADME | R-HSA-9755088 | 8.901234e-01 | 0.051 | 0 | 0 |
| Mitochondrial tRNA aminoacylation | R-HSA-379726 | 8.963975e-01 | 0.047 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 8.986548e-01 | 0.046 | 0 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 8.987600e-01 | 0.046 | 0 | 0 |
| Regulation of IFNA/IFNB signaling | R-HSA-912694 | 8.987600e-01 | 0.046 | 0 | 0 |
| Cellular hexose transport | R-HSA-189200 | 8.987600e-01 | 0.046 | 0 | 0 |
| Cholesterol biosynthesis via lathosterol | R-HSA-6807062 | 8.987600e-01 | 0.046 | 0 | 0 |
| RAF-independent MAPK1/3 activation | R-HSA-112409 | 8.987600e-01 | 0.046 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9694676 | 8.987600e-01 | 0.046 | 0 | 0 |
| Interferon alpha/beta signaling | R-HSA-909733 | 9.014373e-01 | 0.045 | 0 | 0 |
| Purine ribonucleoside monophosphate biosynthesis | R-HSA-73817 | 9.029335e-01 | 0.044 | 0 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 9.052916e-01 | 0.043 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 9.052916e-01 | 0.043 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 9.063309e-01 | 0.043 | 0 | 0 |
| Free fatty acids regulate insulin secretion | R-HSA-400451 | 9.067182e-01 | 0.043 | 0 | 0 |
| Formation of the ureteric bud | R-HSA-9830674 | 9.067182e-01 | 0.043 | 0 | 0 |
| Mitochondrial mRNA modification | R-HSA-9937008 | 9.067182e-01 | 0.043 | 0 | 0 |
| Scavenging by Class A Receptors | R-HSA-3000480 | 9.090827e-01 | 0.041 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 9.090827e-01 | 0.041 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 9.105516e-01 | 0.041 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 9.117907e-01 | 0.040 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.127393e-01 | 0.040 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.127393e-01 | 0.040 | 0 | 0 |
| Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 9.140512e-01 | 0.039 | 0 | 0 |
| Thromboxane signalling through TP receptor | R-HSA-428930 | 9.140512e-01 | 0.039 | 0 | 0 |
| Signaling by FLT3 ITD and TKD mutants | R-HSA-9703648 | 9.140512e-01 | 0.039 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 9.140512e-01 | 0.039 | 0 | 0 |
| Complex III assembly | R-HSA-9865881 | 9.140512e-01 | 0.039 | 0 | 0 |
| Activation of GABAB receptors | R-HSA-991365 | 9.148655e-01 | 0.039 | 0 | 0 |
| GABA B receptor activation | R-HSA-977444 | 9.148655e-01 | 0.039 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 9.155449e-01 | 0.038 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 9.202477e-01 | 0.036 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 9.202829e-01 | 0.036 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 9.208082e-01 | 0.036 | 0 | 0 |
| G protein gated Potassium channels | R-HSA-1296059 | 9.208082e-01 | 0.036 | 0 | 0 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | R-HSA-997272 | 9.208082e-01 | 0.036 | 0 | 0 |
| Activation of G protein gated Potassium channels | R-HSA-1296041 | 9.208082e-01 | 0.036 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 9.208082e-01 | 0.036 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 9.208082e-01 | 0.036 | 0 | 0 |
| Hyaluronan degradation | R-HSA-2160916 | 9.208082e-01 | 0.036 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.235755e-01 | 0.035 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 9.243342e-01 | 0.034 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 9.247768e-01 | 0.034 | 0 | 0 |
| DAP12 interactions | R-HSA-2172127 | 9.254093e-01 | 0.034 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 9.254093e-01 | 0.034 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 9.262480e-01 | 0.033 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.262480e-01 | 0.033 | 0 | 0 |
| MET activates PTK2 signaling | R-HSA-8874081 | 9.270344e-01 | 0.033 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 9.270344e-01 | 0.033 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 9.274227e-01 | 0.033 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 9.327714e-01 | 0.030 | 0 | 0 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 9.327714e-01 | 0.030 | 0 | 0 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 9.327714e-01 | 0.030 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 9.327714e-01 | 0.030 | 0 | 0 |
| CD22 mediated BCR regulation | R-HSA-5690714 | 9.330752e-01 | 0.030 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 9.347120e-01 | 0.029 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 9.347120e-01 | 0.029 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 9.424385e-01 | 0.026 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 9.429077e-01 | 0.026 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 9.429285e-01 | 0.026 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 9.429285e-01 | 0.026 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 9.446753e-01 | 0.025 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.471952e-01 | 0.024 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 9.474166e-01 | 0.023 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 9.474166e-01 | 0.023 | 0 | 0 |
| Neurotransmitter clearance | R-HSA-112311 | 9.474166e-01 | 0.023 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 9.499875e-01 | 0.022 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 9.515520e-01 | 0.022 | 0 | 0 |
| Cargo concentration in the ER | R-HSA-5694530 | 9.515520e-01 | 0.022 | 0 | 0 |
| Complex IV assembly | R-HSA-9864848 | 9.533895e-01 | 0.021 | 0 | 0 |
| Inwardly rectifying K+ channels | R-HSA-1296065 | 9.553624e-01 | 0.020 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 9.553624e-01 | 0.020 | 0 | 0 |
| HS-GAG degradation | R-HSA-2024096 | 9.553624e-01 | 0.020 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 9.559090e-01 | 0.020 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.559417e-01 | 0.020 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 9.564265e-01 | 0.019 | 0 | 0 |
| Interconversion of nucleotide di- and triphosphates | R-HSA-499943 | 9.585010e-01 | 0.018 | 0 | 0 |
| Nucleotide biosynthesis | R-HSA-8956320 | 9.593265e-01 | 0.018 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 9.605659e-01 | 0.017 | 0 | 0 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 9.621083e-01 | 0.017 | 0 | 0 |
| Glutamate and glutamine metabolism | R-HSA-8964539 | 9.621083e-01 | 0.017 | 0 | 0 |
| Glycosaminoglycan-protein linkage region biosynthesis | R-HSA-1971475 | 9.650890e-01 | 0.015 | 0 | 0 |
| Hyaluronan metabolism | R-HSA-2142845 | 9.650890e-01 | 0.015 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 9.655535e-01 | 0.015 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 9.668919e-01 | 0.015 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 9.678354e-01 | 0.014 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 9.678354e-01 | 0.014 | 0 | 0 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 9.678354e-01 | 0.014 | 0 | 0 |
| Defects in vitamin and cofactor metabolism | R-HSA-3296482 | 9.678354e-01 | 0.014 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.690981e-01 | 0.014 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 9.694489e-01 | 0.013 | 0 | 0 |
| HS-GAG biosynthesis | R-HSA-2022928 | 9.703659e-01 | 0.013 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 9.703659e-01 | 0.013 | 0 | 0 |
| Triglyceride catabolism | R-HSA-163560 | 9.703659e-01 | 0.013 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 9.703659e-01 | 0.013 | 0 | 0 |
| Cholesterol biosynthesis | R-HSA-191273 | 9.712824e-01 | 0.013 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 9.713397e-01 | 0.013 | 0 | 0 |
| Voltage gated Potassium channels | R-HSA-1296072 | 9.726974e-01 | 0.012 | 0 | 0 |
| Lysine catabolism | R-HSA-71064 | 9.726974e-01 | 0.012 | 0 | 0 |
| Collagen chain trimerization | R-HSA-8948216 | 9.726974e-01 | 0.012 | 0 | 0 |
| Metabolism of folate and pterines | R-HSA-196757 | 9.726974e-01 | 0.012 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 9.748456e-01 | 0.011 | 0 | 0 |
| GABA receptor activation | R-HSA-977443 | 9.748987e-01 | 0.011 | 0 | 0 |
| Signaling by Retinoic Acid | R-HSA-5362517 | 9.748987e-01 | 0.011 | 0 | 0 |
| Collagen degradation | R-HSA-1442490 | 9.765870e-01 | 0.010 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 9.768250e-01 | 0.010 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 9.768250e-01 | 0.010 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 9.775305e-01 | 0.010 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 9.781017e-01 | 0.010 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 9.781651e-01 | 0.010 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 9.786486e-01 | 0.009 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 9.803289e-01 | 0.009 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 9.818771e-01 | 0.008 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 9.818771e-01 | 0.008 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 9.818771e-01 | 0.008 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 9.820292e-01 | 0.008 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.835078e-01 | 0.007 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.836897e-01 | 0.007 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 9.846176e-01 | 0.007 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 9.846307e-01 | 0.007 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 9.858285e-01 | 0.006 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 9.869440e-01 | 0.006 | 0 | 0 |
| Diseases associated with glycosaminoglycan metabolism | R-HSA-3560782 | 9.869440e-01 | 0.006 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 9.869440e-01 | 0.006 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 9.872772e-01 | 0.006 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 9.875711e-01 | 0.005 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.875711e-01 | 0.005 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.884234e-01 | 0.005 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 9.885086e-01 | 0.005 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 9.891849e-01 | 0.005 | 0 | 0 |
| Plasma lipoprotein remodeling | R-HSA-8963899 | 9.897913e-01 | 0.004 | 0 | 0 |
| FCGR activation | R-HSA-2029481 | 9.902514e-01 | 0.004 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.905951e-01 | 0.004 | 0 | 0 |
| ROS and RNS production in phagocytes | R-HSA-1222556 | 9.906524e-01 | 0.004 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.908184e-01 | 0.004 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 9.908508e-01 | 0.004 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 9.914254e-01 | 0.004 | 0 | 0 |
| Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 9.924912e-01 | 0.003 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 9.929831e-01 | 0.003 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.930731e-01 | 0.003 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 9.932293e-01 | 0.003 | 0 | 0 |
| Paracetamol ADME | R-HSA-9753281 | 9.942509e-01 | 0.003 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 9.943791e-01 | 0.002 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.951209e-01 | 0.002 | 0 | 0 |
| Heparan sulfate/heparin (HS-GAG) metabolism | R-HSA-1638091 | 9.958594e-01 | 0.002 | 0 | 0 |
| Triglyceride metabolism | R-HSA-8979227 | 9.958594e-01 | 0.002 | 0 | 0 |
| RAB geranylgeranylation | R-HSA-8873719 | 9.961857e-01 | 0.002 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 9.961857e-01 | 0.002 | 0 | 0 |
| Complex I biogenesis | R-HSA-6799198 | 9.970182e-01 | 0.001 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 9.978004e-01 | 0.001 | 0 | 0 |
| Metabolism of steroid hormones | R-HSA-196071 | 9.978528e-01 | 0.001 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.978849e-01 | 0.001 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 9.979710e-01 | 0.001 | 0 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.984540e-01 | 0.001 | 0 | 0 |
| Retinoid metabolism and transport | R-HSA-975634 | 9.984540e-01 | 0.001 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 9.984829e-01 | 0.001 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.987847e-01 | 0.001 | 0 | 0 |
| Citric acid cycle (TCA cycle) | R-HSA-71403 | 9.988869e-01 | 0.000 | 0 | 0 |
| SLC-mediated transport of organic anions | R-HSA-9955298 | 9.991301e-01 | 0.000 | 0 | 0 |
| Developmental Lineage of Pancreatic Acinar Cells | R-HSA-9925561 | 9.991987e-01 | 0.000 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.993144e-01 | 0.000 | 0 | 0 |
| Metabolism of fat-soluble vitamins | R-HSA-6806667 | 9.993201e-01 | 0.000 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.995026e-01 | 0.000 | 0 | 0 |
| Antimicrobial peptides | R-HSA-6803157 | 9.995385e-01 | 0.000 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.996357e-01 | 0.000 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.997059e-01 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 9.998330e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation elongation | R-HSA-5389840 | 9.998452e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation initiation | R-HSA-5368286 | 9.998687e-01 | 0.000 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 9.998841e-01 | 0.000 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 9.998874e-01 | 0.000 | 0 | 0 |
| Mitochondrial ribosome-associated quality control | R-HSA-9937383 | 9.999130e-01 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 9.999197e-01 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 9.999207e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation termination | R-HSA-5419276 | 9.999511e-01 | 0.000 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 9.999762e-01 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 9.999893e-01 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 9.999928e-01 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 9.999930e-01 | 0.000 | 0 | 0 |
| Sensory perception of taste | R-HSA-9717189 | 9.999943e-01 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 9.999954e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation | R-HSA-5368287 | 9.999970e-01 | 0.000 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.999971e-01 | 0.000 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 9.999972e-01 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 9.999978e-01 | 0.000 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 9.999990e-01 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 9.999990e-01 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 9.999991e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.999991e-01 | 0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 9.999995e-01 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 9.999995e-01 | 0.000 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 1.000000e+00 | 0.000 | 0 | 0 |
| Infection with Enterobacteria | R-HSA-9640148 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase I - Functionalization of compounds | R-HSA-211945 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | 0.000 | 0 | 0 |
| Expression and translocation of olfactory receptors | R-HSA-9752946 | 1.000000e+00 | -0.000 | 0 | 0 |
| Olfactory Signaling Pathway | R-HSA-381753 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
| RSK activation | R-HSA-444257 | 1.000000e+00 | 0.000 | 1 | 1 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
