SMMLCK

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00264 S54 Sugiyama PGRMC1 HPR6.6 PGRMC LLGLCIFLLYKIVRGDQPAAsGDsDDDEPPPLPRLKRRDFt
O14950 S20 EPSD|PSP MYL12B MRLC2 MYLC2B _MSSKKAKTKTTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
O14950 T19 EPSD|PSP MYL12B MRLC2 MYLC2B __MSSKKAKTKTTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P09923 S111 Sugiyama ALPI DRFPYLALSKTYNVDRQVPDsAATATAYLCGVKANFQTIGL
P10916 S15 EPSD|PSP MYL2 MLC2 ______MAPKKAKKRAGGANsNVFsMFEQTQIQEFKEAFTI
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P19105 T18 EPSD MYL12A MLCB MRLC3 RLC ___MSSKRTKTKTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
P24844 S20 SIGNOR|EPSD|PSP MYL9 MLC2 MRLC1 MYRL2 _MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P24844 T19 SIGNOR|EPSD|PSP MYL9 MLC2 MRLC1 MYRL2 __MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
P25205 T722 Sugiyama MCM3 GDsyDPyDFsDtEEEMPQVHtPKTADsQEtKEsQKVELsES
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
Q05682 S744 SIGNOR CALD1 CAD CDM sPtAAGtPNKEtAGLKVGVSsRINEWLTKtPDGNKsPAPKP
Q12913 S843 Sugiyama PTPRJ DEP1 PNITSVSHNSVKVKFSGFEAsHGPIKAYAVILTTGEAGHPS
Q13765 Y120 Sugiyama NACA HSD48 KNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAAA
Q13769 S314 Sugiyama THOC5 C22orf19 KIAA0983 VDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQLD
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15746 S1438 Sugiyama MYLK MLCK MLCK1 MYLK1 ESELTTVGEKPEEPKDEVEVsDDDEKEPEVDyRTVTINTEQ
Q15746 S1570 Sugiyama MYLK MLCK MLCK1 MYLK1 IIDEDFELTERECIKYMRQIsEGVEyIHKQGIVHLDLKPEN
Q32MK0 S275 Sugiyama MYLK3 MLCK SENLRTGLELAPAPGRVNVVsPSLEVAPGAGQGASSSRPDP
Q32MK0 S401 Sugiyama MYLK3 MLCK CLQAPGTEPGEQtPEGARELsPLQESSsPGGVKAEEEQRAG
Q32MK0 S408 Sugiyama MYLK3 MLCK EPGEQtPEGARELsPLQESSsPGGVKAEEEQRAGAEPGtRP
Q32MK0 S429 Sugiyama MYLK3 MLCK PGGVKAEEEQRAGAEPGtRPsLARSDDNDHEVGALGLQQGK
Q32MK0 T359 Sugiyama MYLK3 MLCK IQEMDTPGEMLMTGRGSLGPtLtTEAPAAAQPGKQGPPGTG
Q32MK0 T361 Sugiyama MYLK3 MLCK EMDTPGEMLMTGRGSLGPtLtTEAPAAAQPGKQGPPGTGRC
Q32MK0 T393 Sugiyama MYLK3 MLCK QGPPGTGRCLQAPGTEPGEQtPEGARELsPLQESSsPGGVK
Q32MK0 T426 Sugiyama MYLK3 MLCK SSsPGGVKAEEEQRAGAEPGtRPsLARSDDNDHEVGALGLQ
Q32MK0 T807 Sugiyama MYLK3 MLCK QLLLQKYIAQRKWKKHFyVVtAANRLRKFPTSP________
Q32MK0 Y804 Sugiyama MYLK3 MLCK LKSQLLLQKYIAQRKWKKHFyVVtAANRLRKFPTSP_____
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q9BRS2 T509 Sugiyama RIOK1 RIO1 QVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHTTDPDI
Q9BX95 S112 Sugiyama SGPP1 SPP1 GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9H6T0 Y326 Sugiyama ESRP2 RBM35B PP7059 VDSEQRDLALQRHKHHMGVRyIEVYKATGEEFVKIAGGTSL
Q9NSY1 S1029 Sugiyama BMP2K BIKE HRIHFB2017 KPTYRtPERARRHKKVGRRDsQssNEFLTIsDSKENISVAL
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Meiotic synapsis R-HSA-1221632 6.005592e-10 9.221 0 0
Cell Cycle R-HSA-1640170 1.119955e-08 7.951 0 0
HATs acetylate histones R-HSA-3214847 1.727943e-08 7.762 0 0
Reproduction R-HSA-1474165 4.900439e-08 7.310 0 0
Chromatin modifying enzymes R-HSA-3247509 1.340809e-07 6.873 0 0
Packaging Of Telomere Ends R-HSA-171306 1.707270e-07 6.768 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.613623e-07 6.792 0 0
Cell Cycle, Mitotic R-HSA-69278 2.320350e-07 6.634 0 0
Meiosis R-HSA-1500620 4.164916e-07 6.380 0 0
Chromatin organization R-HSA-4839726 4.975988e-07 6.303 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.107984e-07 6.292 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.411848e-07 6.130 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.093434e-07 6.092 0 0
Cell Cycle Checkpoints R-HSA-69620 1.036518e-06 5.984 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.113167e-06 5.953 0 0
Signal Transduction R-HSA-162582 1.172604e-06 5.931 1 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.612236e-06 5.793 0 0
Cellular Senescence R-HSA-2559583 1.597813e-06 5.796 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.612236e-06 5.793 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.709967e-06 5.567 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.284135e-06 5.484 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.175829e-06 5.498 0 0
Cleavage of the damaged purine R-HSA-110331 3.288551e-06 5.483 0 0
Nucleosome assembly R-HSA-774815 4.049757e-06 5.393 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.049757e-06 5.393 0 0
Depurination R-HSA-73927 4.117663e-06 5.385 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.126291e-06 5.213 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.809356e-06 5.107 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.731047e-06 5.059 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.163718e-05 4.934 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.165386e-05 4.934 0 0
Depyrimidination R-HSA-73928 1.165386e-05 4.934 0 0
Diseases of programmed cell death R-HSA-9645723 1.205011e-05 4.919 0 0
DNA methylation R-HSA-5334118 1.439459e-05 4.842 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.500686e-05 4.824 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.848401e-05 4.733 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.816879e-05 4.741 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.354941e-05 4.628 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.471854e-05 4.459 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.866451e-05 4.413 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.866451e-05 4.413 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.866451e-05 4.413 0 0
M Phase R-HSA-68886 4.565615e-05 4.341 0 0
Defective pyroptosis R-HSA-9710421 6.871429e-05 4.163 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.009657e-05 4.045 0 0
HDACs deacetylate histones R-HSA-3214815 1.044082e-04 3.981 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.208654e-04 3.918 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.295740e-04 3.887 0 0
Specification of primordial germ cells R-HSA-9827857 1.437466e-04 3.842 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.563121e-04 3.806 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.617121e-04 3.791 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.596376e-04 3.797 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.792135e-04 3.747 0 0
FOXO-mediated transcription R-HSA-9614085 1.820411e-04 3.740 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.910230e-04 3.719 0 0
Mitotic Prophase R-HSA-68875 1.946468e-04 3.711 0 0
Chromosome Maintenance R-HSA-73886 2.126357e-04 3.672 0 0
Meiotic recombination R-HSA-912446 2.394747e-04 3.621 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.427448e-04 3.615 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.822714e-04 3.549 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.163161e-04 3.500 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.247020e-04 3.489 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.247020e-04 3.489 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.210117e-04 3.493 0 0
Axon guidance R-HSA-422475 3.358185e-04 3.474 0 0
Netrin-1 signaling R-HSA-373752 3.568075e-04 3.448 0 0
Telomere Maintenance R-HSA-157579 4.589500e-04 3.338 0 0
NRAGE signals death through JNK R-HSA-193648 4.698305e-04 3.328 0 0
G alpha (12/13) signalling events R-HSA-416482 4.987653e-04 3.302 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.767124e-04 3.322 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.812808e-04 3.167 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.814145e-04 3.167 0 0
Nervous system development R-HSA-9675108 7.337556e-04 3.134 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.436679e-04 3.129 0 0
Ub-specific processing proteases R-HSA-5689880 8.723053e-04 3.059 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.174190e-04 3.037 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.051505e-03 2.978 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.403401e-03 2.853 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.408639e-03 2.851 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.427528e-03 2.845 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.575030e-03 2.803 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.710972e-03 2.767 0 0
DNA Double Strand Break Response R-HSA-5693606 1.657018e-03 2.781 0 0
Ion homeostasis R-HSA-5578775 1.683756e-03 2.774 0 0
Base Excision Repair R-HSA-73884 1.743630e-03 2.759 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.807195e-03 2.743 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.899920e-03 2.721 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.067163e-03 2.685 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.462278e-03 2.609 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.462278e-03 2.609 0 0
G2/M Checkpoints R-HSA-69481 2.562400e-03 2.591 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.593638e-03 2.586 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.706437e-03 2.568 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.969761e-03 2.527 0 0
Homology Directed Repair R-HSA-5693538 3.176729e-03 2.498 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.217946e-03 2.492 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.217946e-03 2.492 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 3.562335e-03 2.448 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.562335e-03 2.448 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.562335e-03 2.448 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.516108e-03 2.454 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.664253e-03 2.436 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.395204e-03 2.357 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.395204e-03 2.357 0 0
Mitotic Anaphase R-HSA-68882 4.581907e-03 2.339 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.805481e-03 2.318 0 0
S Phase R-HSA-69242 4.925864e-03 2.308 0 0
Cell junction organization R-HSA-446728 5.102408e-03 2.292 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.169067e-03 2.287 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.193335e-03 2.285 0 0
Amyloid fiber formation R-HSA-977225 5.899857e-03 2.229 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.401862e-03 2.194 0 0
DNA Replication R-HSA-69306 6.520253e-03 2.186 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.627552e-03 2.179 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.613118e-03 2.118 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.829887e-03 2.106 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 7.847939e-03 2.105 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.159999e-03 2.088 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 8.687096e-03 2.061 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.955250e-03 2.048 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 9.132166e-03 2.039 0 0
Developmental Biology R-HSA-1266738 9.370892e-03 2.028 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.012397e-02 1.995 0 0
Semaphorin interactions R-HSA-373755 1.040081e-02 1.983 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.051637e-02 1.978 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.073203e-02 1.969 0 0
FLT3 Signaling R-HSA-9607240 1.131247e-02 1.946 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.142917e-02 1.942 0 0
Separation of Sister Chromatids R-HSA-2467813 1.150703e-02 1.939 0 0
Cell-Cell communication R-HSA-1500931 1.202080e-02 1.920 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.374818e-02 1.862 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.274051e-02 1.895 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.295117e-02 1.888 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.373156e-02 1.862 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.295117e-02 1.888 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.340560e-02 1.873 0 0
RNA Polymerase I Transcription R-HSA-73864 1.245833e-02 1.905 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.425145e-02 1.846 0 0
Cellular responses to stress R-HSA-2262752 1.466093e-02 1.834 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.605427e-02 1.794 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.741949e-02 1.759 0 0
Regulation of TP53 Expression R-HSA-6804754 1.741949e-02 1.759 0 0
Cardiac conduction R-HSA-5576891 1.772311e-02 1.751 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.778540e-02 1.750 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.799012e-02 1.745 0 0
Neurodegenerative Diseases R-HSA-8863678 1.827899e-02 1.738 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.827899e-02 1.738 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.874901e-02 1.727 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.874901e-02 1.727 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.069787e-02 1.684 0 0
ESR-mediated signaling R-HSA-8939211 2.100361e-02 1.678 0 0
Apoptotic execution phase R-HSA-75153 2.011115e-02 1.697 0 0
Regulation of TP53 Activity R-HSA-5633007 1.912513e-02 1.718 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.149015e-02 1.668 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.149477e-02 1.668 0 0
RET signaling R-HSA-8853659 2.218173e-02 1.654 0 0
Mitotic Prometaphase R-HSA-68877 2.237941e-02 1.650 0 0
RAB geranylgeranylation R-HSA-8873719 2.249724e-02 1.648 0 0
Deubiquitination R-HSA-5688426 2.273838e-02 1.643 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.290589e-02 1.640 0 0
TRP channels R-HSA-3295583 2.331659e-02 1.632 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.395510e-02 1.621 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.445014e-02 1.612 0 0
HCMV Early Events R-HSA-9609690 2.521605e-02 1.598 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.537545e-02 1.596 0 0
Signaling by Hippo R-HSA-2028269 2.542993e-02 1.595 0 0
Protein ubiquitination R-HSA-8852135 2.545405e-02 1.594 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 2.634652e-02 1.579 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.924245e-02 1.534 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.924245e-02 1.534 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.802666e-02 1.552 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.634652e-02 1.579 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.924245e-02 1.534 0 0
Death Receptor Signaling R-HSA-73887 2.858987e-02 1.544 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.809124e-02 1.551 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.614022e-02 1.583 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.944015e-02 1.531 0 0
HSF1-dependent transactivation R-HSA-3371571 3.040849e-02 1.517 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.132066e-02 1.504 0 0
Signaling by WNT R-HSA-195721 3.228227e-02 1.491 0 0
Adherens junctions interactions R-HSA-418990 3.307597e-02 1.480 0 0
Cell-cell junction organization R-HSA-421270 3.415408e-02 1.467 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.588288e-02 1.445 0 0
Interleukin-37 signaling R-HSA-9008059 3.588288e-02 1.445 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.672946e-02 1.435 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.672946e-02 1.435 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.672946e-02 1.435 0 0
Dopamine receptors R-HSA-390651 3.672946e-02 1.435 0 0
Cellular responses to stimuli R-HSA-8953897 3.765019e-02 1.424 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.783204e-02 1.422 0 0
Gene Silencing by RNA R-HSA-211000 3.936470e-02 1.405 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.016255e-02 1.396 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.016255e-02 1.396 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.033898e-02 1.394 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.771875e-02 1.321 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.771875e-02 1.321 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.703027e-02 1.328 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.747316e-02 1.324 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.759710e-02 1.322 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.771875e-02 1.321 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.771875e-02 1.321 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.797057e-02 1.319 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.823299e-02 1.317 0 0
IRS activation R-HSA-74713 4.840591e-02 1.315 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.840591e-02 1.315 0 0
NrCAM interactions R-HSA-447038 4.840591e-02 1.315 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.933774e-02 1.307 0 0
G1/S Transition R-HSA-69206 5.172716e-02 1.286 0 0
Gene expression (Transcription) R-HSA-74160 5.303020e-02 1.275 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.443511e-02 1.264 0 0
G2/M Transition R-HSA-69275 5.572603e-02 1.254 0 0
RNA Polymerase II Transcription R-HSA-73857 5.730333e-02 1.242 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.963054e-02 1.225 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.989522e-02 1.223 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.122578e-02 1.213 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.132537e-02 1.212 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.238644e-02 1.205 0 0
Programmed Cell Death R-HSA-5357801 6.304471e-02 1.200 0 0
DCC mediated attractive signaling R-HSA-418885 7.078785e-02 1.150 0 0
mRNA Splicing - Major Pathway R-HSA-72163 7.245478e-02 1.140 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 7.078785e-02 1.150 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.803385e-02 1.108 0 0
Long-term potentiation R-HSA-9620244 7.134587e-02 1.147 0 0
EPH-Ephrin signaling R-HSA-2682334 7.324326e-02 1.135 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.852402e-02 1.164 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.852402e-02 1.164 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.772156e-02 1.169 0 0
Apoptosis R-HSA-109581 7.152071e-02 1.146 0 0
MAPK family signaling cascades R-HSA-5683057 7.627867e-02 1.118 0 0
Formation of the anterior neural plate R-HSA-9823739 7.078785e-02 1.150 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.554584e-02 1.183 0 0
Interleukin-7 signaling R-HSA-1266695 7.134587e-02 1.147 0 0
Cell-extracellular matrix interactions R-HSA-446353 7.078785e-02 1.150 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.661805e-02 1.176 0 0
Muscle contraction R-HSA-397014 7.807426e-02 1.107 1 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.969652e-02 1.099 0 0
Phase 4 - resting membrane potential R-HSA-5576886 7.969652e-02 1.099 0 0
Cellular response to heat stress R-HSA-3371556 7.972719e-02 1.098 0 0
Stimuli-sensing channels R-HSA-2672351 8.205528e-02 1.086 0 0
mRNA 3'-end processing R-HSA-72187 8.273645e-02 1.082 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.275025e-02 1.082 0 0
Diseases of Telomere Maintenance R-HSA-9673013 9.492654e-02 1.023 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 9.492654e-02 1.023 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 9.492654e-02 1.023 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 9.492654e-02 1.023 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 9.492654e-02 1.023 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 9.492654e-02 1.023 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 9.492654e-02 1.023 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 9.492654e-02 1.023 0 0
SOS-mediated signalling R-HSA-112412 8.975219e-02 1.047 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 8.975219e-02 1.047 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 8.975219e-02 1.047 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.052131e-01 0.978 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.052131e-01 0.978 0 0
Type I hemidesmosome assembly R-HSA-446107 1.052131e-01 0.978 0 0
Activation of RAS in B cells R-HSA-1169092 1.052131e-01 0.978 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.906456e-02 1.050 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.906456e-02 1.050 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.886881e-02 1.005 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.987490e-02 1.001 0 0
Attenuation phase R-HSA-3371568 8.865226e-02 1.052 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.781127e-02 1.056 0 0
mRNA Splicing R-HSA-72172 1.004397e-01 0.998 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.152669e-02 1.038 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.476700e-02 1.023 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.039489e-01 0.983 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.039489e-01 0.983 0 0
Adrenoceptors R-HSA-390696 1.052131e-01 0.978 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.010909e-01 0.995 0 0
HCMV Infection R-HSA-9609646 8.812173e-02 1.055 0 0
Potassium Channels R-HSA-1296071 9.152669e-02 1.038 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 8.975219e-02 1.047 0 0
Signaling by VEGF R-HSA-194138 9.627094e-02 1.017 0 0
MTOR signalling R-HSA-165159 1.076199e-01 0.968 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.906456e-02 1.050 0 0
PKMTs methylate histone lysines R-HSA-3214841 9.476700e-02 1.023 0 0
Generic Transcription Pathway R-HSA-212436 9.608791e-02 1.017 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.022094e-01 0.991 0 0
Ion channel transport R-HSA-983712 1.028797e-01 0.988 0 0
MECP2 regulates transcription factors R-HSA-9022707 8.975219e-02 1.047 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.052131e-01 0.978 0 0
Signaling by NOTCH R-HSA-157118 1.058506e-01 0.975 0 0
Signaling by Interleukins R-HSA-449147 9.790064e-02 1.009 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.067879e-01 0.971 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.077213e-01 0.968 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.077213e-01 0.968 0 0
Polo-like kinase mediated events R-HSA-156711 1.090852e-01 0.962 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.090852e-01 0.962 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.142711e-01 0.942 0 0
Signaling by SCF-KIT R-HSA-1433557 1.143497e-01 0.942 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.147204e-01 0.940 0 0
Signaling by ERBB4 R-HSA-1236394 1.196266e-01 0.922 0 0
Rap1 signalling R-HSA-392517 1.196890e-01 0.922 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 1.213248e-01 0.916 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.213248e-01 0.916 0 0
Adipogenesis R-HSA-9843745 1.226274e-01 0.911 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.240953e-01 0.906 0 0
Rab regulation of trafficking R-HSA-9007101 1.245465e-01 0.905 0 0
Signaling by ERBB2 R-HSA-1227986 1.278840e-01 0.893 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.283925e-01 0.891 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.306551e-01 0.884 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.306551e-01 0.884 0 0
Protein hydroxylation R-HSA-9629569 1.306551e-01 0.884 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 1.389592e-01 0.857 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.389592e-01 0.857 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 1.389592e-01 0.857 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.389592e-01 0.857 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.389592e-01 0.857 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.389592e-01 0.857 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.389592e-01 0.857 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.389592e-01 0.857 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.808522e-01 0.743 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.808522e-01 0.743 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 1.808522e-01 0.743 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.808522e-01 0.743 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 1.808522e-01 0.743 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.808522e-01 0.743 0 0
Potassium transport channels R-HSA-1296067 1.808522e-01 0.743 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.808522e-01 0.743 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.808522e-01 0.743 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.808522e-01 0.743 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.808522e-01 0.743 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 1.808522e-01 0.743 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.808522e-01 0.743 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.808522e-01 0.743 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 1.808522e-01 0.743 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.808522e-01 0.743 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.808522e-01 0.743 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 1.808522e-01 0.743 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 2.207093e-01 0.656 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 2.207093e-01 0.656 0 0
Invadopodia formation R-HSA-8941237 2.207093e-01 0.656 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.586294e-01 0.587 0 0
HCN channels R-HSA-1296061 2.586294e-01 0.587 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.586294e-01 0.587 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.586294e-01 0.587 0 0
ATP sensitive Potassium channels R-HSA-1296025 2.586294e-01 0.587 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.586294e-01 0.587 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.379876e-01 0.860 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.379876e-01 0.860 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.379876e-01 0.860 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.947065e-01 0.531 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.947065e-01 0.531 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.947065e-01 0.531 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.947065e-01 0.531 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.947065e-01 0.531 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.947065e-01 0.531 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 2.947065e-01 0.531 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.726076e-01 0.763 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.726076e-01 0.763 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.904040e-01 0.720 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.290301e-01 0.483 0 0
PKB-mediated events R-HSA-109703 3.290301e-01 0.483 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.290301e-01 0.483 0 0
PDE3B signalling R-HSA-165160 3.290301e-01 0.483 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.290301e-01 0.483 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.290301e-01 0.483 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.290301e-01 0.483 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.290301e-01 0.483 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.290301e-01 0.483 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.290301e-01 0.483 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.084287e-01 0.681 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.419581e-01 0.848 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.266174e-01 0.645 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.616853e-01 0.442 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.616853e-01 0.442 0 0
STAT5 Activation R-HSA-9645135 3.616853e-01 0.442 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.616853e-01 0.442 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.616853e-01 0.442 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.616853e-01 0.442 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.449116e-01 0.611 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.449116e-01 0.611 0 0
Phosphorylation of the APC/C R-HSA-176412 2.632581e-01 0.580 0 0
Netrin mediated repulsion signals R-HSA-418886 3.927531e-01 0.406 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.927531e-01 0.406 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.927531e-01 0.406 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.927531e-01 0.406 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.927531e-01 0.406 0 0
Disinhibition of SNARE formation R-HSA-114516 3.927531e-01 0.406 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.927531e-01 0.406 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.816086e-01 0.550 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.816086e-01 0.550 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 2.283934e-01 0.641 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.283934e-01 0.641 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.999193e-01 0.523 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.223105e-01 0.374 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.223105e-01 0.374 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.342292e-01 0.872 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.181507e-01 0.497 0 0
Late endosomal microautophagy R-HSA-9615710 2.547134e-01 0.594 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.680306e-01 0.572 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.362673e-01 0.473 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.362673e-01 0.473 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.504310e-01 0.346 0 0
Lipophagy R-HSA-9613354 4.504310e-01 0.346 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.504310e-01 0.346 0 0
CASP8 activity is inhibited R-HSA-5218900 4.504310e-01 0.346 0 0
ALK mutants bind TKIs R-HSA-9700645 4.504310e-01 0.346 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.302290e-01 0.638 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.899306e-01 0.721 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.668714e-01 0.778 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.623452e-01 0.581 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.083662e-01 0.511 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.083662e-01 0.511 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.720314e-01 0.429 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.720314e-01 0.429 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.218761e-01 0.492 0 0
snRNP Assembly R-HSA-191859 2.446708e-01 0.611 0 0
Metabolism of non-coding RNA R-HSA-194441 2.446708e-01 0.611 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.842049e-01 0.546 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.896250e-01 0.409 0 0
Notch-HLH transcription pathway R-HSA-350054 4.069951e-01 0.390 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.069951e-01 0.390 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.026367e-01 0.299 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 5.026367e-01 0.299 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.026367e-01 0.299 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.026367e-01 0.299 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.026367e-01 0.299 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.623568e-01 0.441 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.286011e-01 0.483 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.241220e-01 0.373 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.011180e-01 0.521 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.509697e-01 0.455 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.509697e-01 0.455 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.409881e-01 0.356 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.268514e-01 0.278 0 0
Activation of RAC1 R-HSA-428540 5.268514e-01 0.278 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.268514e-01 0.278 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.300877e-01 0.481 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.621621e-01 0.441 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.621621e-01 0.441 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.024433e-01 0.395 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.156543e-01 0.381 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.845171e-01 0.415 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.956622e-01 0.403 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.350738e-01 0.475 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.788370e-01 0.422 0 0
Centrosome maturation R-HSA-380287 3.983513e-01 0.400 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.055720e-01 0.296 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.055720e-01 0.296 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.274909e-01 0.369 0 0
Signaling by Erythropoietin R-HSA-9006335 5.209462e-01 0.283 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.209462e-01 0.283 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.209462e-01 0.283 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.925554e-01 0.308 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.925554e-01 0.308 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.048933e-01 0.297 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.170742e-01 0.286 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.041150e-01 0.297 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.419201e-01 0.616 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.154340e-01 0.667 0 0
Formation of definitive endoderm R-HSA-9823730 3.542370e-01 0.451 0 0
Telomere Extension By Telomerase R-HSA-171319 2.414939e-01 0.617 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.542370e-01 0.451 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.154340e-01 0.667 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.927531e-01 0.406 0 0
EGFR downregulation R-HSA-182971 2.814249e-01 0.551 0 0
Signaling by EGFR R-HSA-177929 3.956622e-01 0.403 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.898805e-01 0.310 0 0
Extension of Telomeres R-HSA-180786 4.288699e-01 0.368 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.379876e-01 0.860 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.084287e-01 0.681 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.771842e-01 0.321 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.771842e-01 0.321 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.268514e-01 0.278 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.417783e-01 0.355 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.880237e-01 0.541 0 0
PI3K/AKT activation R-HSA-198203 1.379876e-01 0.860 0 0
Formation of apoptosome R-HSA-111458 4.771842e-01 0.321 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.816086e-01 0.550 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.948765e-01 0.530 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.449116e-01 0.611 0 0
Telomere C-strand synthesis initiation R-HSA-174430 2.449116e-01 0.611 0 0
RAF activation R-HSA-5673000 1.507744e-01 0.822 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.816086e-01 0.550 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 4.223105e-01 0.374 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.223105e-01 0.374 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.342292e-01 0.872 0 0
Trafficking of AMPA receptors R-HSA-399719 2.814249e-01 0.551 0 0
Orc1 removal from chromatin R-HSA-68949 3.509697e-01 0.455 0 0
Inwardly rectifying K+ channels R-HSA-1296065 2.948765e-01 0.530 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.048933e-01 0.297 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.048933e-01 0.297 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.048933e-01 0.297 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.024433e-01 0.395 0 0
Neurexins and neuroligins R-HSA-6794361 1.830767e-01 0.737 0 0
Signaling by ROBO receptors R-HSA-376176 1.496130e-01 0.825 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.864415e-01 0.729 0 0
Formation of the posterior neural plate R-HSA-9832991 1.551098e-01 0.809 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.904040e-01 0.720 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.328301e-01 0.877 0 0
mRNA Editing: C to U Conversion R-HSA-72200 3.927531e-01 0.406 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.026386e-01 0.693 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.999193e-01 0.523 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.547134e-01 0.594 0 0
Aggrephagy R-HSA-9646399 2.094025e-01 0.679 0 0
IRS-mediated signalling R-HSA-112399 2.265073e-01 0.645 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.203945e-01 0.494 0 0
Tight junction interactions R-HSA-420029 4.575783e-01 0.340 0 0
Interleukin-2 signaling R-HSA-9020558 5.026367e-01 0.299 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.114502e-01 0.386 0 0
Signaling by WNT in cancer R-HSA-4791275 2.948765e-01 0.530 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.212661e-01 0.493 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 2.586294e-01 0.587 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.947065e-01 0.531 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.290301e-01 0.483 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 2.449116e-01 0.611 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.999193e-01 0.523 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 4.771842e-01 0.321 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.206405e-01 0.656 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.891483e-01 0.410 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 5.268514e-01 0.278 0 0
Cyclin D associated events in G1 R-HSA-69231 4.800672e-01 0.319 0 0
G1 Phase R-HSA-69236 4.800672e-01 0.319 0 0
DARPP-32 events R-HSA-180024 5.209462e-01 0.283 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.128093e-01 0.672 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.616853e-01 0.442 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.218761e-01 0.492 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.519623e-01 0.818 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.488875e-01 0.457 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 5.209462e-01 0.283 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.283934e-01 0.641 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.362673e-01 0.473 0 0
Signaling by RAS mutants R-HSA-6802949 5.048933e-01 0.297 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.864415e-01 0.729 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.206405e-01 0.656 0 0
IGF1R signaling cascade R-HSA-2428924 1.541266e-01 0.812 0 0
DAP12 signaling R-HSA-2424491 2.680306e-01 0.572 0 0
Generation of second messenger molecules R-HSA-202433 4.156543e-01 0.381 0 0
Signaling by BMP R-HSA-201451 4.898805e-01 0.310 0 0
G0 and Early G1 R-HSA-1538133 2.948765e-01 0.530 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.151315e-01 0.288 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.672073e-01 0.330 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 1.808522e-01 0.743 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.586294e-01 0.587 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.586294e-01 0.587 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.551098e-01 0.809 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.947065e-01 0.531 0 0
Formation of the Editosome R-HSA-75094 3.290301e-01 0.483 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.290301e-01 0.483 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.084287e-01 0.681 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.084287e-01 0.681 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.927531e-01 0.406 0 0
Cristae formation R-HSA-8949613 2.283934e-01 0.641 0 0
Regulation by c-FLIP R-HSA-3371378 4.223105e-01 0.374 0 0
PI3K Cascade R-HSA-109704 1.666455e-01 0.778 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.504310e-01 0.346 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.771842e-01 0.321 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.771842e-01 0.321 0 0
Signaling by APC mutants R-HSA-4839744 5.026367e-01 0.299 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.268514e-01 0.278 0 0
ERKs are inactivated R-HSA-202670 5.268514e-01 0.278 0 0
Signaling by AXIN mutants R-HSA-4839735 5.268514e-01 0.278 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.268514e-01 0.278 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.167644e-01 0.380 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.615801e-01 0.336 0 0
Synthesis of DNA R-HSA-69239 3.830753e-01 0.417 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.328301e-01 0.877 0 0
Insulin receptor signalling cascade R-HSA-74751 2.915484e-01 0.535 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.610341e-01 0.793 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.154340e-01 0.667 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.265073e-01 0.645 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.900304e-01 0.721 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.927531e-01 0.406 0 0
Signaling by FGFR in disease R-HSA-1226099 2.285661e-01 0.641 0 0
Signal attenuation R-HSA-74749 1.379876e-01 0.860 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.156543e-01 0.381 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.156543e-01 0.381 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.898805e-01 0.310 0 0
Interleukin-1 signaling R-HSA-9020702 4.859462e-01 0.313 0 0
FLT3 signaling in disease R-HSA-9682385 1.695800e-01 0.771 0 0
Co-stimulation by CD28 R-HSA-389356 1.508345e-01 0.821 0 0
Integrin signaling R-HSA-354192 1.328301e-01 0.877 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.119181e-01 0.506 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.467662e-01 0.350 0 0
Neuronal System R-HSA-112316 3.224006e-01 0.492 0 0
Regulated Necrosis R-HSA-5218859 5.248200e-01 0.280 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 5.248200e-01 0.280 0 0
Signaling by LTK R-HSA-9842663 1.904040e-01 0.720 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.290301e-01 0.483 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.927531e-01 0.406 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.223105e-01 0.374 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.504310e-01 0.346 0 0
Interleukin-1 processing R-HSA-448706 4.504310e-01 0.346 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.112078e-01 0.386 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.999872e-01 0.699 0 0
Membrane Trafficking R-HSA-199991 4.793737e-01 0.319 0 0
Autophagy R-HSA-9612973 5.015618e-01 0.300 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.904040e-01 0.720 0 0
mTORC1-mediated signalling R-HSA-166208 1.654726e-01 0.781 0 0
Regulation of BACH1 activity R-HSA-9708530 2.632581e-01 0.580 0 0
TGFBR3 expression R-HSA-9839394 2.026386e-01 0.693 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.738795e-01 0.324 0 0
Platelet calcium homeostasis R-HSA-418360 5.209462e-01 0.283 0 0
Gastrulation R-HSA-9758941 4.533318e-01 0.344 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.732378e-01 0.563 0 0
HCMV Late Events R-HSA-9610379 1.701719e-01 0.769 0 0
Kinesins R-HSA-983189 4.398380e-01 0.357 0 0
HDMs demethylate histones R-HSA-3214842 4.575783e-01 0.340 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.433527e-01 0.844 0 0
Signaling by PTK6 R-HSA-8848021 2.820340e-01 0.550 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.820340e-01 0.550 0 0
Interleukin-1 family signaling R-HSA-446652 2.332461e-01 0.632 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.389592e-01 0.857 0 0
DSCAM interactions R-HSA-376172 1.808522e-01 0.743 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.379876e-01 0.860 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.947065e-01 0.531 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.927531e-01 0.406 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.223105e-01 0.374 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.223105e-01 0.374 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.223105e-01 0.374 0 0
Dimerization of procaspase-8 R-HSA-69416 4.223105e-01 0.374 0 0
Amine ligand-binding receptors R-HSA-375280 2.623452e-01 0.581 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.083662e-01 0.511 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.353887e-01 0.474 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.026367e-01 0.299 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.268514e-01 0.278 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.268514e-01 0.278 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.733476e-01 0.428 0 0
GABA receptor activation R-HSA-977443 4.398380e-01 0.357 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.055720e-01 0.296 0 0
DNA Repair R-HSA-73894 3.473459e-01 0.459 0 0
Sensory processing of sound R-HSA-9659379 4.371471e-01 0.359 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.999193e-01 0.523 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.223105e-01 0.374 0 0
Ion transport by P-type ATPases R-HSA-936837 2.915484e-01 0.535 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.616853e-01 0.442 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.328301e-01 0.877 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.328301e-01 0.877 0 0
Recycling pathway of L1 R-HSA-437239 2.952356e-01 0.530 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.248200e-01 0.280 0 0
Post NMDA receptor activation events R-HSA-438064 5.218350e-01 0.282 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.181507e-01 0.497 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.725818e-01 0.565 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 4.738795e-01 0.324 0 0
DAP12 interactions R-HSA-2172127 4.800672e-01 0.319 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.956622e-01 0.403 0 0
Specification of the neural plate border R-HSA-9834899 3.362673e-01 0.473 0 0
G-protein beta:gamma signalling R-HSA-397795 3.083662e-01 0.511 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.697766e-01 0.432 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.495502e-01 0.456 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.859462e-01 0.313 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.586294e-01 0.587 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.947065e-01 0.531 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 3.290301e-01 0.483 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.084287e-01 0.681 0 0
Regulation of PTEN localization R-HSA-8948747 3.927531e-01 0.406 0 0
Glycoprotein hormones R-HSA-209822 3.927531e-01 0.406 0 0
Passive transport by Aquaporins R-HSA-432047 2.816086e-01 0.550 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.223105e-01 0.374 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.504310e-01 0.346 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.504310e-01 0.346 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.771842e-01 0.321 0 0
Bicarbonate transporters R-HSA-425381 5.026367e-01 0.299 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.241220e-01 0.373 0 0
Sodium/Calcium exchangers R-HSA-425561 5.268514e-01 0.278 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.956622e-01 0.403 0 0
Cellular response to hypoxia R-HSA-1234174 4.936142e-01 0.307 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.593064e-01 0.445 0 0
Adaptive Immune System R-HSA-1280218 4.195102e-01 0.377 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.464602e-01 0.608 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.417783e-01 0.355 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.771842e-01 0.321 0 0
Signaling by ALK in cancer R-HSA-9700206 2.464602e-01 0.608 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 4.504310e-01 0.346 0 0
mRNA Editing R-HSA-75072 4.504310e-01 0.346 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.720314e-01 0.429 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.218761e-01 0.492 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.830212e-01 0.316 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.654726e-01 0.781 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.507744e-01 0.822 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.287696e-01 0.368 0 0
Myogenesis R-HSA-525793 4.738795e-01 0.324 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 4.417783e-01 0.355 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.898805e-01 0.310 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.947065e-01 0.531 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.290301e-01 0.483 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.290301e-01 0.483 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.084287e-01 0.681 0 0
Leukotriene receptors R-HSA-391906 3.616853e-01 0.442 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.927531e-01 0.406 0 0
CHL1 interactions R-HSA-447041 3.927531e-01 0.406 0 0
Synthesis of PG R-HSA-1483148 2.816086e-01 0.550 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.504310e-01 0.346 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 4.504310e-01 0.346 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.083662e-01 0.511 0 0
Peptide hormone biosynthesis R-HSA-209952 4.771842e-01 0.321 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.026367e-01 0.299 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 5.026367e-01 0.299 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 5.026367e-01 0.299 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.026367e-01 0.299 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.112549e-01 0.291 0 0
Co-inhibition by PD-1 R-HSA-389948 1.387506e-01 0.858 0 0
Potential therapeutics for SARS R-HSA-9679191 3.307657e-01 0.480 0 0
Integration of energy metabolism R-HSA-163685 4.946894e-01 0.306 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 1.891544e-01 0.723 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.449116e-01 0.611 0 0
G1/S-Specific Transcription R-HSA-69205 1.695800e-01 0.771 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.156543e-01 0.381 0 0
Signaling by TGFBR3 R-HSA-9839373 2.842049e-01 0.546 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.547134e-01 0.594 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.820340e-01 0.550 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.464436e-01 0.460 0 0
Activation of BH3-only proteins R-HSA-114452 2.680306e-01 0.572 0 0
PI Metabolism R-HSA-1483255 2.068521e-01 0.684 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.551098e-01 0.809 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.509697e-01 0.455 0 0
Cardiogenesis R-HSA-9733709 3.083662e-01 0.511 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.535724e-01 0.814 0 0
Signaling by ALK R-HSA-201556 1.992002e-01 0.701 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.504310e-01 0.346 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.771842e-01 0.321 0 0
Suppression of apoptosis R-HSA-9635465 5.026367e-01 0.299 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.026367e-01 0.299 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.371471e-01 0.359 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 4.178026e-01 0.379 0 0
L1CAM interactions R-HSA-373760 3.243981e-01 0.489 0 0
Regulation of beta-cell development R-HSA-186712 4.288699e-01 0.368 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.504310e-01 0.346 0 0
Signaling by Leptin R-HSA-2586552 1.379876e-01 0.860 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.223105e-01 0.374 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.504310e-01 0.346 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.623568e-01 0.441 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.181507e-01 0.497 0 0
Pyroptosis R-HSA-5620971 5.055720e-01 0.296 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.738795e-01 0.324 0 0
IRE1alpha activates chaperones R-HSA-381070 1.365578e-01 0.865 0 0
Insulin processing R-HSA-264876 4.898805e-01 0.310 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.163564e-01 0.287 0 0
Growth hormone receptor signaling R-HSA-982772 4.241220e-01 0.373 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.290919e-01 0.276 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.306258e-01 0.275 0 0
Selective autophagy R-HSA-9663891 5.309217e-01 0.275 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.359968e-01 0.271 0 0
Activation of the pre-replicative complex R-HSA-68962 5.359968e-01 0.271 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.359968e-01 0.271 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.359968e-01 0.271 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.359968e-01 0.271 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.359968e-01 0.271 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 5.359968e-01 0.271 0 0
DNA Damage Bypass R-HSA-73893 5.409409e-01 0.267 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.442426e-01 0.264 0 0
COPII-mediated vesicle transport R-HSA-204005 5.451000e-01 0.264 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.451000e-01 0.264 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.488581e-01 0.261 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.498887e-01 0.260 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.498887e-01 0.260 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.498887e-01 0.260 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.498887e-01 0.260 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.498887e-01 0.260 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.498887e-01 0.260 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.498887e-01 0.260 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.498887e-01 0.260 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.498887e-01 0.260 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.498887e-01 0.260 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.498887e-01 0.260 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.498887e-01 0.260 0 0
Repression of WNT target genes R-HSA-4641265 5.498887e-01 0.260 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.498887e-01 0.260 0 0
Polymerase switching R-HSA-69091 5.498887e-01 0.260 0 0
Leading Strand Synthesis R-HSA-69109 5.498887e-01 0.260 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.498887e-01 0.260 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.498887e-01 0.260 0 0
Disorders of Nervous System Development R-HSA-9697154 5.498887e-01 0.260 0 0
Pervasive developmental disorders R-HSA-9005895 5.498887e-01 0.260 0 0
Estrogen biosynthesis R-HSA-193144 5.498887e-01 0.260 0 0
Interleukin-15 signaling R-HSA-8983432 5.498887e-01 0.260 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.498887e-01 0.260 0 0
OAS antiviral response R-HSA-8983711 5.498887e-01 0.260 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 5.507188e-01 0.259 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.523364e-01 0.258 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.523364e-01 0.258 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.536558e-01 0.257 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.649230e-01 0.248 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.651086e-01 0.248 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.664585e-01 0.247 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.718056e-01 0.243 0 0
Formation of axial mesoderm R-HSA-9796292 5.718056e-01 0.243 0 0
Frs2-mediated activation R-HSA-170968 5.718056e-01 0.243 0 0
Chylomicron remodeling R-HSA-8963901 5.718056e-01 0.243 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.718056e-01 0.243 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.718056e-01 0.243 0 0
rRNA modification in the mitochondrion R-HSA-6793080 5.718056e-01 0.243 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 5.718056e-01 0.243 0 0
Maturation of nucleoprotein R-HSA-9683610 5.718056e-01 0.243 0 0
Signaling by Insulin receptor R-HSA-74752 5.751258e-01 0.240 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.791636e-01 0.237 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.791636e-01 0.237 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.791636e-01 0.237 0 0
Nuclear RNA decay R-HSA-9930044 5.791636e-01 0.237 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.791636e-01 0.237 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.791636e-01 0.237 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 5.837013e-01 0.234 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.840291e-01 0.234 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.840291e-01 0.234 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.842621e-01 0.233 0 0
Signaling by NOTCH4 R-HSA-9013694 5.842621e-01 0.233 0 0
Amino acids regulate mTORC1 R-HSA-9639288 5.865584e-01 0.232 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.865584e-01 0.232 0 0
Collagen formation R-HSA-1474290 5.921827e-01 0.228 0 0
Removal of the Flap Intermediate R-HSA-69166 5.926566e-01 0.227 0 0
cGMP effects R-HSA-418457 5.926566e-01 0.227 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.926566e-01 0.227 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.926566e-01 0.227 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.926566e-01 0.227 0 0
Physiological factors R-HSA-5578768 5.926566e-01 0.227 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.926566e-01 0.227 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.926566e-01 0.227 0 0
Regulation of KIT signaling R-HSA-1433559 5.926566e-01 0.227 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.926566e-01 0.227 0 0
Signal regulatory protein family interactions R-HSA-391160 5.926566e-01 0.227 0 0
Striated Muscle Contraction R-HSA-390522 5.928824e-01 0.227 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.928824e-01 0.227 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.928824e-01 0.227 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.928824e-01 0.227 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.974996e-01 0.224 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.051683e-01 0.218 0 0
eNOS activation R-HSA-203615 6.062642e-01 0.217 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.062642e-01 0.217 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.062642e-01 0.217 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.073060e-01 0.217 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.088547e-01 0.215 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.124790e-01 0.213 0 0
Erythropoietin activates RAS R-HSA-9027284 6.124935e-01 0.213 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.124935e-01 0.213 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.124935e-01 0.213 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.124935e-01 0.213 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.124935e-01 0.213 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.124935e-01 0.213 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.124935e-01 0.213 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.124935e-01 0.213 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.124935e-01 0.213 0 0
Signaling by Activin R-HSA-1502540 6.124935e-01 0.213 0 0
p75NTR signals via NF-kB R-HSA-193639 6.124935e-01 0.213 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.124935e-01 0.213 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.124935e-01 0.213 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.124935e-01 0.213 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.124935e-01 0.213 0 0
Protein methylation R-HSA-8876725 6.124935e-01 0.213 0 0
DNA Damage Reversal R-HSA-73942 6.124935e-01 0.213 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.170415e-01 0.210 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.188068e-01 0.208 0 0
TNF signaling R-HSA-75893 6.188068e-01 0.208 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.193095e-01 0.208 0 0
Interleukin-10 signaling R-HSA-6783783 6.214006e-01 0.207 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.313655e-01 0.200 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.313655e-01 0.200 0 0
Prolonged ERK activation events R-HSA-169893 6.313655e-01 0.200 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.313655e-01 0.200 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.313655e-01 0.200 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.313655e-01 0.200 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.313655e-01 0.200 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.313655e-01 0.200 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.313655e-01 0.200 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.313655e-01 0.200 0 0
Differentiation of T cells R-HSA-9945266 6.313655e-01 0.200 0 0
HSF1 activation R-HSA-3371511 6.320192e-01 0.199 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.320192e-01 0.199 0 0
RNA Polymerase III Transcription R-HSA-74158 6.320192e-01 0.199 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.320192e-01 0.199 0 0
Triglyceride catabolism R-HSA-163560 6.320192e-01 0.199 0 0
Calmodulin induced events R-HSA-111933 6.320192e-01 0.199 0 0
CaM pathway R-HSA-111997 6.320192e-01 0.199 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.330861e-01 0.199 0 0
Glucose metabolism R-HSA-70326 6.365708e-01 0.196 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.391660e-01 0.194 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.443175e-01 0.191 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.443950e-01 0.191 0 0
SLC-mediated transport of organic cations R-HSA-549127 6.443950e-01 0.191 0 0
Collagen chain trimerization R-HSA-8948216 6.443950e-01 0.191 0 0
Glycolysis R-HSA-70171 6.487569e-01 0.188 0 0
Triglyceride metabolism R-HSA-8979227 6.493041e-01 0.188 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.493195e-01 0.188 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.493195e-01 0.188 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.493195e-01 0.188 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 6.493195e-01 0.188 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.493195e-01 0.188 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.493195e-01 0.188 0 0
Disorders of Developmental Biology R-HSA-9675151 6.493195e-01 0.188 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.493195e-01 0.188 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.493195e-01 0.188 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.564394e-01 0.183 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.564394e-01 0.183 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.590753e-01 0.181 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.590753e-01 0.181 0 0
PTEN Regulation R-HSA-6807070 6.600332e-01 0.180 0 0
Signaling by TGFB family members R-HSA-9006936 6.626655e-01 0.179 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.639776e-01 0.178 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.664000e-01 0.176 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.664000e-01 0.176 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.664000e-01 0.176 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.664000e-01 0.176 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.664000e-01 0.176 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.664000e-01 0.176 0 0
Choline catabolism R-HSA-6798163 6.664000e-01 0.176 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.664000e-01 0.176 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.664000e-01 0.176 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.681553e-01 0.175 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.681553e-01 0.175 0 0
Stabilization of p53 R-HSA-69541 6.681553e-01 0.175 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.681553e-01 0.175 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.686485e-01 0.175 0 0
Aquaporin-mediated transport R-HSA-445717 6.686485e-01 0.175 0 0
Collagen degradation R-HSA-1442490 6.686485e-01 0.175 0 0
Macroautophagy R-HSA-1632852 6.727786e-01 0.172 0 0
Neutrophil degranulation R-HSA-6798695 6.773924e-01 0.169 0 0
Heme signaling R-HSA-9707616 6.780236e-01 0.169 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.780236e-01 0.169 0 0
Cellular response to chemical stress R-HSA-9711123 6.781629e-01 0.169 0 0
MHC class II antigen presentation R-HSA-2132295 6.783312e-01 0.169 0 0
Opioid Signalling R-HSA-111885 6.787630e-01 0.168 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.787630e-01 0.168 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.795460e-01 0.168 0 0
HIV Transcription Elongation R-HSA-167169 6.795460e-01 0.168 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.795460e-01 0.168 0 0
Diseases of Immune System R-HSA-5260271 6.795460e-01 0.168 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.795460e-01 0.168 0 0
Interleukin-2 family signaling R-HSA-451927 6.795460e-01 0.168 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.795460e-01 0.168 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.826497e-01 0.166 0 0
GAB1 signalosome R-HSA-180292 6.826497e-01 0.166 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.826497e-01 0.166 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.826497e-01 0.166 0 0
Apoptotic factor-mediated response R-HSA-111471 6.826497e-01 0.166 0 0
Ephrin signaling R-HSA-3928664 6.826497e-01 0.166 0 0
Platelet sensitization by LDL R-HSA-432142 6.826497e-01 0.166 0 0
Tie2 Signaling R-HSA-210993 6.826497e-01 0.166 0 0
Mismatch Repair R-HSA-5358508 6.826497e-01 0.166 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.826497e-01 0.166 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.872010e-01 0.163 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.872010e-01 0.163 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.872010e-01 0.163 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.906155e-01 0.161 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.906155e-01 0.161 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.918304e-01 0.160 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.981087e-01 0.156 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.981087e-01 0.156 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.981087e-01 0.156 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.981087e-01 0.156 0 0
Pyrimidine biosynthesis R-HSA-500753 6.981087e-01 0.156 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.981087e-01 0.156 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.981087e-01 0.156 0 0
The NLRP3 inflammasome R-HSA-844456 6.981087e-01 0.156 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.981087e-01 0.156 0 0
Maturation of nucleoprotein R-HSA-9694631 6.981087e-01 0.156 0 0
Other interleukin signaling R-HSA-449836 6.981087e-01 0.156 0 0
Platelet homeostasis R-HSA-418346 7.001139e-01 0.155 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.013680e-01 0.154 0 0
MAP2K and MAPK activation R-HSA-5674135 7.013680e-01 0.154 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.013680e-01 0.154 0 0
Intra-Golgi traffic R-HSA-6811438 7.013680e-01 0.154 0 0
Phospholipid metabolism R-HSA-1483257 7.033715e-01 0.153 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.118081e-01 0.148 0 0
Ca-dependent events R-HSA-111996 7.118081e-01 0.148 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.118081e-01 0.148 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.121811e-01 0.147 0 0
Peptide chain elongation R-HSA-156902 7.121811e-01 0.147 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.128156e-01 0.147 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.128156e-01 0.147 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.128156e-01 0.147 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.128156e-01 0.147 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.128156e-01 0.147 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.128156e-01 0.147 0 0
Signaling by NODAL R-HSA-1181150 7.128156e-01 0.147 0 0
Signal transduction by L1 R-HSA-445144 7.128156e-01 0.147 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.128156e-01 0.147 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.137917e-01 0.146 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.137917e-01 0.146 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.149905e-01 0.146 0 0
ER-Phagosome pathway R-HSA-1236974 7.195848e-01 0.143 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.207105e-01 0.142 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.219407e-01 0.141 0 0
TBC/RABGAPs R-HSA-8854214 7.219407e-01 0.141 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.268069e-01 0.139 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.268069e-01 0.139 0 0
G-protein activation R-HSA-202040 7.268069e-01 0.139 0 0
Lagging Strand Synthesis R-HSA-69186 7.268069e-01 0.139 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.268069e-01 0.139 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.268069e-01 0.139 0 0
ERK/MAPK targets R-HSA-198753 7.268069e-01 0.139 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.268069e-01 0.139 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 7.268069e-01 0.139 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.268069e-01 0.139 0 0
Basigin interactions R-HSA-210991 7.268069e-01 0.139 0 0
TCR signaling R-HSA-202403 7.270231e-01 0.138 0 0
Transmission across Chemical Synapses R-HSA-112315 7.300479e-01 0.137 0 0
RMTs methylate histone arginines R-HSA-3214858 7.317710e-01 0.136 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.339679e-01 0.134 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.401174e-01 0.131 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.401174e-01 0.131 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.401174e-01 0.131 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.401174e-01 0.131 0 0
Glutathione synthesis and recycling R-HSA-174403 7.401174e-01 0.131 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.401174e-01 0.131 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.401174e-01 0.131 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.401174e-01 0.131 0 0
Metabolism of RNA R-HSA-8953854 7.405512e-01 0.130 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.413044e-01 0.130 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.413044e-01 0.130 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.413044e-01 0.130 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.413044e-01 0.130 0 0
DAG and IP3 signaling R-HSA-1489509 7.413044e-01 0.130 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.459772e-01 0.127 0 0
Circadian clock R-HSA-9909396 7.464526e-01 0.127 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.477892e-01 0.126 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.505464e-01 0.125 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.505464e-01 0.125 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.505464e-01 0.125 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.505464e-01 0.125 0 0
Diseases of DNA repair R-HSA-9675135 7.505464e-01 0.125 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.505464e-01 0.125 0 0
Developmental Cell Lineages R-HSA-9734767 7.515845e-01 0.124 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.520937e-01 0.124 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.521496e-01 0.124 0 0
FGFR2 alternative splicing R-HSA-6803529 7.527801e-01 0.123 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.527801e-01 0.123 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.527801e-01 0.123 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.527801e-01 0.123 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.527801e-01 0.123 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.527801e-01 0.123 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.527801e-01 0.123 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.527801e-01 0.123 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.527801e-01 0.123 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.527801e-01 0.123 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.536098e-01 0.123 0 0
Hedgehog 'on' state R-HSA-5632684 7.536098e-01 0.123 0 0
G alpha (q) signalling events R-HSA-416476 7.556862e-01 0.122 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.595029e-01 0.119 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.648265e-01 0.116 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.648265e-01 0.116 0 0
Syndecan interactions R-HSA-3000170 7.648265e-01 0.116 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.674815e-01 0.115 0 0
Intraflagellar transport R-HSA-5620924 7.681796e-01 0.115 0 0
Ca2+ pathway R-HSA-4086398 7.683206e-01 0.114 0 0
Cellular response to starvation R-HSA-9711097 7.735903e-01 0.111 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.737723e-01 0.111 0 0
Eukaryotic Translation Termination R-HSA-72764 7.737723e-01 0.111 0 0
ROS and RNS production in phagocytes R-HSA-1222556 7.754033e-01 0.110 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.755129e-01 0.110 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.755129e-01 0.110 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.762867e-01 0.110 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.762867e-01 0.110 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.762867e-01 0.110 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.762867e-01 0.110 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 7.762867e-01 0.110 0 0
Deadenylation of mRNA R-HSA-429947 7.762867e-01 0.110 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.762867e-01 0.110 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 7.762867e-01 0.110 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.762867e-01 0.110 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 7.765826e-01 0.110 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.799285e-01 0.108 0 0
Mitochondrial biogenesis R-HSA-1592230 7.810823e-01 0.107 0 0
Viral Infection Pathways R-HSA-9824446 7.825457e-01 0.106 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.847179e-01 0.105 0 0
SARS-CoV Infections R-HSA-9679506 7.859031e-01 0.105 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.859513e-01 0.105 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.871890e-01 0.104 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.871890e-01 0.104 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.871890e-01 0.104 0 0
G protein gated Potassium channels R-HSA-1296059 7.871890e-01 0.104 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.871890e-01 0.104 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.871890e-01 0.104 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.871890e-01 0.104 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.871890e-01 0.104 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.871890e-01 0.104 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.871890e-01 0.104 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.871890e-01 0.104 0 0
Signaling by NOTCH1 R-HSA-1980143 7.890353e-01 0.103 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.918419e-01 0.101 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.918419e-01 0.101 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.918419e-01 0.101 0 0
Regulation of insulin secretion R-HSA-422356 7.918419e-01 0.101 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.919005e-01 0.101 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.919005e-01 0.101 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.925916e-01 0.101 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.925916e-01 0.101 0 0
The phototransduction cascade R-HSA-2514856 7.925916e-01 0.101 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.939476e-01 0.100 0 0
Parasite infection R-HSA-9664407 7.939476e-01 0.100 0 0
Leishmania phagocytosis R-HSA-9664417 7.939476e-01 0.100 0 0
MET activates PTK2 signaling R-HSA-8874081 7.975607e-01 0.098 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.975607e-01 0.098 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.975607e-01 0.098 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.975607e-01 0.098 0 0
Metalloprotease DUBs R-HSA-5689901 7.975607e-01 0.098 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.975607e-01 0.098 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.002100e-01 0.097 0 0
ABC transporter disorders R-HSA-5619084 8.019733e-01 0.096 0 0
PCP/CE pathway R-HSA-4086400 8.019733e-01 0.096 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.073389e-01 0.093 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.073389e-01 0.093 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.074275e-01 0.093 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.074275e-01 0.093 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.074275e-01 0.093 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.074275e-01 0.093 0 0
Triglyceride biosynthesis R-HSA-75109 8.074275e-01 0.093 0 0
Synthesis of PE R-HSA-1483213 8.074275e-01 0.093 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.074275e-01 0.093 0 0
Smooth Muscle Contraction R-HSA-445355 8.075791e-01 0.093 1 1
Selenocysteine synthesis R-HSA-2408557 8.087358e-01 0.092 0 0
SLC transporter disorders R-HSA-5619102 8.145480e-01 0.089 0 0
Translation initiation complex formation R-HSA-72649 8.147052e-01 0.089 0 0
HIV elongation arrest and recovery R-HSA-167287 8.168139e-01 0.088 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.168139e-01 0.088 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.168139e-01 0.088 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.168139e-01 0.088 0 0
Inflammasomes R-HSA-622312 8.168139e-01 0.088 0 0
Host Interactions of HIV factors R-HSA-162909 8.171164e-01 0.088 0 0
Cilium Assembly R-HSA-5617833 8.171834e-01 0.088 0 0
Immune System R-HSA-168256 8.184836e-01 0.087 0 0
Viral mRNA Translation R-HSA-192823 8.193654e-01 0.087 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.215944e-01 0.085 0 0
Signaling by NOTCH3 R-HSA-9012852 8.215944e-01 0.085 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 8.244952e-01 0.084 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.257434e-01 0.083 0 0
Thyroxine biosynthesis R-HSA-209968 8.257434e-01 0.083 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.257434e-01 0.083 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 8.257434e-01 0.083 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.257434e-01 0.083 0 0
mRNA Capping R-HSA-72086 8.257434e-01 0.083 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.257434e-01 0.083 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.257434e-01 0.083 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.282529e-01 0.082 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.282529e-01 0.082 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.308070e-01 0.080 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.314259e-01 0.080 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 8.342381e-01 0.079 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.342381e-01 0.079 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.342381e-01 0.079 0 0
Signaling by NTRKs R-HSA-166520 8.343062e-01 0.079 0 0
Synthesis of PA R-HSA-1483166 8.346868e-01 0.078 0 0
Platelet degranulation R-HSA-114608 8.354742e-01 0.078 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.391650e-01 0.076 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.398209e-01 0.076 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.409022e-01 0.075 0 0
GPCR downstream signalling R-HSA-388396 8.417673e-01 0.075 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.421103e-01 0.075 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.423193e-01 0.075 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.423193e-01 0.075 0 0
Budding and maturation of HIV virion R-HSA-162588 8.423193e-01 0.075 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.423193e-01 0.075 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.423193e-01 0.075 0 0
Cargo concentration in the ER R-HSA-5694530 8.423193e-01 0.075 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.423193e-01 0.075 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.423193e-01 0.075 0 0
Downstream signal transduction R-HSA-186763 8.423193e-01 0.075 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.469050e-01 0.072 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.469050e-01 0.072 0 0
Neddylation R-HSA-8951664 8.481054e-01 0.072 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.483631e-01 0.071 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 8.495247e-01 0.071 0 0
DNA strand elongation R-HSA-69190 8.500069e-01 0.071 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.500069e-01 0.071 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.500858e-01 0.071 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.522035e-01 0.069 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.522035e-01 0.069 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.527012e-01 0.069 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.527012e-01 0.069 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.527012e-01 0.069 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.527012e-01 0.069 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.527012e-01 0.069 0 0
Signaling by Retinoic Acid R-HSA-5362517 8.527012e-01 0.069 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.527931e-01 0.069 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.561146e-01 0.067 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.573201e-01 0.067 0 0
Defective B3GALTL causes PpS R-HSA-5083635 8.573201e-01 0.067 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.573201e-01 0.067 0 0
PLC beta mediated events R-HSA-112043 8.582967e-01 0.066 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.582967e-01 0.066 0 0
MAP kinase activation R-HSA-450294 8.582967e-01 0.066 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.630679e-01 0.064 0 0
Mitochondrial protein import R-HSA-1268020 8.636972e-01 0.064 0 0
Signaling by PDGF R-HSA-186797 8.636972e-01 0.064 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.642772e-01 0.063 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.642772e-01 0.063 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.642772e-01 0.063 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.642772e-01 0.063 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.642772e-01 0.063 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.642772e-01 0.063 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.653630e-01 0.063 0 0
Inositol phosphate metabolism R-HSA-1483249 8.654290e-01 0.063 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.694293e-01 0.061 0 0
Neurotransmitter release cycle R-HSA-112310 8.707123e-01 0.060 0 0
Dual Incision in GG-NER R-HSA-5696400 8.708955e-01 0.060 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.708955e-01 0.060 0 0
Nuclear import of Rev protein R-HSA-180746 8.708955e-01 0.060 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.708955e-01 0.060 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.708955e-01 0.060 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.708955e-01 0.060 0 0
Signal amplification R-HSA-392518 8.708955e-01 0.060 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.708955e-01 0.060 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.708955e-01 0.060 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.771914e-01 0.057 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.771914e-01 0.057 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.771914e-01 0.057 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.771914e-01 0.057 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.771914e-01 0.057 0 0
Regulation of Apoptosis R-HSA-169911 8.771914e-01 0.057 0 0
Signalling to ERKs R-HSA-187687 8.771914e-01 0.057 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.771914e-01 0.057 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.782900e-01 0.056 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 8.787856e-01 0.056 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.795265e-01 0.056 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.808217e-01 0.055 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.816660e-01 0.055 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.831807e-01 0.054 0 0
GPVI-mediated activation cascade R-HSA-114604 8.831807e-01 0.054 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.831807e-01 0.054 0 0
Ribosome-associated quality control R-HSA-9948299 8.849617e-01 0.053 0 0
G-protein mediated events R-HSA-112040 8.879717e-01 0.052 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.879717e-01 0.052 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 8.888782e-01 0.051 0 0
Voltage gated Potassium channels R-HSA-1296072 8.888782e-01 0.051 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.888782e-01 0.051 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.888782e-01 0.051 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.888782e-01 0.051 0 0
Degradation of DVL R-HSA-4641258 8.888782e-01 0.051 0 0
Degradation of AXIN R-HSA-4641257 8.888782e-01 0.051 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.888782e-01 0.051 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.888782e-01 0.051 0 0
Lysine catabolism R-HSA-71064 8.888782e-01 0.051 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.904504e-01 0.050 0 0
Peptide hormone metabolism R-HSA-2980736 8.913412e-01 0.050 0 0
Transcription of the HIV genome R-HSA-167172 8.923187e-01 0.049 0 0
MET promotes cell motility R-HSA-8875878 8.942982e-01 0.049 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.942982e-01 0.049 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.946379e-01 0.048 0 0
Vesicle-mediated transport R-HSA-5653656 8.975654e-01 0.047 0 0
Toll-like Receptor Cascades R-HSA-168898 8.984386e-01 0.047 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.994541e-01 0.046 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.994541e-01 0.046 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.994541e-01 0.046 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.002840e-01 0.046 0 0
Interleukin-17 signaling R-HSA-448424 9.005464e-01 0.045 0 0
Signaling by GPCR R-HSA-372790 9.040495e-01 0.044 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.040973e-01 0.044 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.043588e-01 0.044 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.043588e-01 0.044 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.043588e-01 0.044 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.043588e-01 0.044 0 0
Metabolism of cofactors R-HSA-8978934 9.044369e-01 0.044 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.081848e-01 0.042 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.081848e-01 0.042 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.090246e-01 0.041 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.090246e-01 0.041 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.090246e-01 0.041 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.090246e-01 0.041 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.090246e-01 0.041 0 0
Maturation of spike protein R-HSA-9694548 9.090246e-01 0.041 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.134630e-01 0.039 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.134630e-01 0.039 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.134630e-01 0.039 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.134630e-01 0.039 0 0
Translation of Structural Proteins R-HSA-9683701 9.134630e-01 0.039 0 0
ABC-family proteins mediated transport R-HSA-382556 9.145109e-01 0.039 0 0
Hedgehog 'off' state R-HSA-5610787 9.145109e-01 0.039 0 0
Activation of GABAB receptors R-HSA-991365 9.176851e-01 0.037 0 0
GABA B receptor activation R-HSA-977444 9.176851e-01 0.037 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.176851e-01 0.037 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.186191e-01 0.037 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.207874e-01 0.036 0 0
Signaling by FGFR4 R-HSA-5654743 9.217015e-01 0.035 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.217015e-01 0.035 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.217015e-01 0.035 0 0
Interleukin-12 signaling R-HSA-9020591 9.218421e-01 0.035 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.236288e-01 0.035 0 0
Translation of Structural Proteins R-HSA-9694635 9.249446e-01 0.034 0 0
HIV Infection R-HSA-162906 9.250180e-01 0.034 0 0
Proteasome assembly R-HSA-9907900 9.255221e-01 0.034 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.283980e-01 0.032 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.291565e-01 0.032 0 0
Signaling by FGFR3 R-HSA-5654741 9.291565e-01 0.032 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.291565e-01 0.032 0 0
Somitogenesis R-HSA-9824272 9.291565e-01 0.032 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.308044e-01 0.031 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.309140e-01 0.031 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.320955e-01 0.031 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.326138e-01 0.030 0 0
Signaling by FGFR2 R-HSA-5654738 9.335695e-01 0.030 0 0
PKR-mediated signaling R-HSA-9833482 9.335695e-01 0.030 0 0
rRNA processing R-HSA-72312 9.339733e-01 0.030 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.359026e-01 0.029 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.359026e-01 0.029 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.359026e-01 0.029 0 0
Synthesis of PC R-HSA-1483191 9.359026e-01 0.029 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.362298e-01 0.029 0 0
NGF-stimulated transcription R-HSA-9031628 9.390310e-01 0.027 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.390310e-01 0.027 0 0
Gluconeogenesis R-HSA-70263 9.390310e-01 0.027 0 0
Metal ion SLC transporters R-HSA-425410 9.390310e-01 0.027 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.412502e-01 0.026 0 0
Degradation of CDH1 R-HSA-9766229 9.420070e-01 0.026 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.423162e-01 0.026 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.423162e-01 0.026 0 0
Complex IV assembly R-HSA-9864848 9.475306e-01 0.023 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.475306e-01 0.023 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.480823e-01 0.023 0 0
Signaling by Hedgehog R-HSA-5358351 9.499520e-01 0.022 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.500922e-01 0.022 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.500922e-01 0.022 0 0
Interleukin-12 family signaling R-HSA-447115 9.522089e-01 0.021 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.525288e-01 0.021 0 0
Nucleotide biosynthesis R-HSA-8956320 9.525288e-01 0.021 0 0
Post-translational protein modification R-HSA-597592 9.532198e-01 0.021 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.536902e-01 0.021 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.553690e-01 0.020 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.553690e-01 0.020 0 0
G alpha (z) signalling events R-HSA-418597 9.570513e-01 0.019 0 0
Late Phase of HIV Life Cycle R-HSA-162599 9.577211e-01 0.019 0 0
Downstream TCR signaling R-HSA-202424 9.578163e-01 0.019 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.591486e-01 0.018 0 0
Signaling by FGFR1 R-HSA-5654736 9.591486e-01 0.018 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.591486e-01 0.018 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.599197e-01 0.018 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.605046e-01 0.018 0 0
Dectin-2 family R-HSA-5621480 9.611435e-01 0.017 0 0
Regulation of CDH1 Function R-HSA-9764561 9.611435e-01 0.017 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.627905e-01 0.016 0 0
Dual incision in TC-NER R-HSA-6782135 9.630412e-01 0.016 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.630412e-01 0.016 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.630412e-01 0.016 0 0
Leishmania infection R-HSA-9658195 9.640090e-01 0.016 0 0
Parasitic Infection Pathways R-HSA-9824443 9.640090e-01 0.016 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.648463e-01 0.016 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.649281e-01 0.016 0 0
Glutathione conjugation R-HSA-156590 9.665633e-01 0.015 0 0
Metabolism of polyamines R-HSA-351202 9.665633e-01 0.015 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.681965e-01 0.014 0 0
Influenza Infection R-HSA-168255 9.689978e-01 0.014 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.697501e-01 0.013 0 0
tRNA processing in the nucleus R-HSA-6784531 9.697501e-01 0.013 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.720445e-01 0.012 0 0
Signaling by FGFR R-HSA-190236 9.723012e-01 0.012 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.726336e-01 0.012 0 0
HIV Life Cycle R-HSA-162587 9.748370e-01 0.011 0 0
Nicotinate metabolism R-HSA-196807 9.764522e-01 0.010 0 0
Metabolism of steroid hormones R-HSA-196071 9.764522e-01 0.010 0 0
Interferon gamma signaling R-HSA-877300 9.765510e-01 0.010 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.782149e-01 0.010 0 0
RSV-host interactions R-HSA-9833110 9.794447e-01 0.009 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.797386e-01 0.009 0 0
Selenoamino acid metabolism R-HSA-2408522 9.803680e-01 0.009 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.807289e-01 0.008 0 0
Retinoid metabolism and transport R-HSA-975634 9.807289e-01 0.008 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.816708e-01 0.008 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.842296e-01 0.007 0 0
ISG15 antiviral mechanism R-HSA-1169408 9.842296e-01 0.007 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.842296e-01 0.007 0 0
UCH proteinases R-HSA-5689603 9.850006e-01 0.007 0 0
G alpha (s) signalling events R-HSA-418555 9.852803e-01 0.006 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.854321e-01 0.006 0 0
Cholesterol biosynthesis R-HSA-191273 9.864316e-01 0.006 0 0
Integrin cell surface interactions R-HSA-216083 9.864316e-01 0.006 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.870951e-01 0.006 0 0
Signaling by MET R-HSA-6806834 9.877262e-01 0.005 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.883264e-01 0.005 0 0
Visual phototransduction R-HSA-2187338 9.887819e-01 0.005 0 0
Hemostasis R-HSA-109582 9.899004e-01 0.004 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.899569e-01 0.004 0 0
Transport of small molecules R-HSA-382551 9.909301e-01 0.004 0 0
Extracellular matrix organization R-HSA-1474244 9.911238e-01 0.004 0 0
Protein localization R-HSA-9609507 9.911624e-01 0.004 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.917827e-01 0.004 0 0
PPARA activates gene expression R-HSA-1989781 9.918415e-01 0.004 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.924701e-01 0.003 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.937055e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.939188e-01 0.003 0 0
Protein folding R-HSA-391251 9.939188e-01 0.003 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.952685e-01 0.002 0 0
Innate Immune System R-HSA-168249 9.957853e-01 0.002 0 0
Disease R-HSA-1643685 9.968398e-01 0.001 0 0
Nucleotide Excision Repair R-HSA-5696398 9.971364e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.979681e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.985187e-01 0.001 0 0
Sphingolipid metabolism R-HSA-428157 9.988215e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.988412e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.990035e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.991431e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.993664e-01 0.000 0 0
Interferon Signaling R-HSA-913531 9.993700e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.994522e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.995231e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.995545e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.995699e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.997473e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.998454e-01 0.000 0 0
Translation R-HSA-72766 9.998760e-01 0.000 0 0
tRNA processing R-HSA-72306 9.999237e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999344e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999344e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999490e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999500e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999523e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999624e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999656e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999660e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999709e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999876e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999882e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999905e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999969e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999978e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999997e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999997e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.469174e-10 9.607 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.052688e-10 9.392 0 0
Attenuation phase R-HSA-3371568 5.427737e-10 9.265 0 0
mRNA Splicing R-HSA-72172 1.547049e-09 8.810 0 0
HSF1-dependent transactivation R-HSA-3371571 7.966703e-08 7.099 0 0
Cellular response to heat stress R-HSA-3371556 1.266598e-07 6.897 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.874375e-07 6.727 0 0
HSF1 activation R-HSA-3371511 3.026485e-07 6.519 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.902684e-06 5.721 0 0
Metabolism of RNA R-HSA-8953854 2.750388e-06 5.561 0 0
Cell Cycle R-HSA-1640170 3.772251e-06 5.423 0 0
Apoptotic execution phase R-HSA-75153 1.359831e-05 4.867 0 0
Chromatin organization R-HSA-4839726 2.013363e-05 4.696 0 0
M Phase R-HSA-68886 2.439871e-05 4.613 0 0
Cell Cycle, Mitotic R-HSA-69278 2.467404e-05 4.608 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.206955e-05 4.656 0 0
Nervous system development R-HSA-9675108 5.511157e-05 4.259 0 0
Chromatin modifying enzymes R-HSA-3247509 5.632415e-05 4.249 0 0
Apoptosis R-HSA-109581 6.645569e-05 4.177 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.257567e-05 4.139 0 0
Cellular responses to stimuli R-HSA-8953897 7.597386e-05 4.119 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.142031e-05 4.089 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 9.625258e-05 4.017 0 0
Axon guidance R-HSA-422475 1.672758e-04 3.777 0 0
mRNA 3'-end processing R-HSA-72187 1.768208e-04 3.752 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.050424e-04 3.688 0 0
Programmed Cell Death R-HSA-5357801 2.804757e-04 3.552 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.458231e-04 3.461 0 0
Metalloprotease DUBs R-HSA-5689901 3.024487e-04 3.519 0 0
Mitotic Anaphase R-HSA-68882 3.207971e-04 3.494 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.561060e-04 3.448 0 0
Regulation of TP53 Activity R-HSA-5633007 3.119018e-04 3.506 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.581772e-04 3.446 0 0
Signaling by ALK in cancer R-HSA-9700206 3.581772e-04 3.446 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.049044e-04 3.393 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.118598e-04 3.385 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.517681e-04 3.258 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.127887e-04 3.290 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.881227e-04 3.311 0 0
Regulation of CDH1 Function R-HSA-9764561 5.275369e-04 3.278 0 0
Membrane Trafficking R-HSA-199991 5.098516e-04 3.293 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.376746e-04 3.269 0 0
Cellular responses to stress R-HSA-2262752 5.383816e-04 3.269 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.433192e-04 3.265 0 0
Cell Cycle Checkpoints R-HSA-69620 6.507963e-04 3.187 0 0
IRE1alpha activates chaperones R-HSA-381070 6.998699e-04 3.155 0 0
Mitotic Prophase R-HSA-68875 8.177907e-04 3.087 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.342288e-04 3.079 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.319201e-04 3.080 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 9.098830e-04 3.041 0 0
Signaling by ERBB2 R-HSA-1227986 9.517290e-04 3.021 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.741388e-04 3.011 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.258818e-03 2.900 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.200693e-03 2.921 0 0
Deubiquitination R-HSA-5688426 1.224760e-03 2.912 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.291590e-03 2.889 0 0
Signaling by NOTCH4 R-HSA-9013694 1.153789e-03 2.938 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.258818e-03 2.900 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.564541e-03 2.806 0 0
Signaling by PTK6 R-HSA-8848021 1.643122e-03 2.784 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.643122e-03 2.784 0 0
Signaling by VEGF R-HSA-194138 1.740160e-03 2.759 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.689776e-03 2.772 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.077116e-03 2.683 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.089216e-03 2.680 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.337133e-03 2.631 0 0
Separation of Sister Chromatids R-HSA-2467813 2.450049e-03 2.611 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.649026e-03 2.577 0 0
Striated Muscle Contraction R-HSA-390522 2.673843e-03 2.573 0 0
MTF1 activates gene expression R-HSA-5660489 3.153965e-03 2.501 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.019115e-03 2.396 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.019115e-03 2.396 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.986237e-03 2.399 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.023154e-03 2.395 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.272914e-03 2.369 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.232191e-03 2.373 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.272914e-03 2.369 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.119276e-03 2.385 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.272914e-03 2.369 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.167725e-03 2.287 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 5.167725e-03 2.287 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.052906e-03 2.296 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.833998e-03 2.316 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.172424e-03 2.286 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.119616e-03 2.291 0 0
Co-stimulation by CD28 R-HSA-389356 5.319829e-03 2.274 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.984219e-03 2.223 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.731223e-03 2.242 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.731223e-03 2.242 0 0
UCH proteinases R-HSA-5689603 6.163905e-03 2.210 0 0
Mitotic Prometaphase R-HSA-68877 6.049343e-03 2.218 0 0
Signaling by NOTCH1 R-HSA-1980143 6.163905e-03 2.210 0 0
Smooth Muscle Contraction R-HSA-445355 5.897013e-03 2.229 1 1
Negative regulation of FLT3 R-HSA-9706369 5.897591e-03 2.229 0 0
Regulation of PTEN localization R-HSA-8948747 6.193126e-03 2.208 0 0
FLT3 Signaling R-HSA-9607240 5.963892e-03 2.224 0 0
Regulation of signaling by CBL R-HSA-912631 6.428185e-03 2.192 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.428185e-03 2.192 0 0
Notch-HLH transcription pathway R-HSA-350054 6.691667e-03 2.174 0 0
G2/M Checkpoints R-HSA-69481 6.410561e-03 2.193 0 0
Activation of BH3-only proteins R-HSA-114452 6.678447e-03 2.175 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.933356e-03 2.159 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.110335e-03 2.148 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.264292e-03 2.083 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.017550e-03 2.096 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.953641e-03 2.099 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.814801e-03 2.107 0 0
Negative regulation of MET activity R-HSA-6807004 8.403268e-03 2.076 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.403268e-03 2.076 0 0
Epigenetic regulation of gene expression R-HSA-212165 8.420810e-03 2.075 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.546417e-03 2.068 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.573849e-03 2.067 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 9.252617e-03 2.034 0 0
Mitotic Spindle Checkpoint R-HSA-69618 9.173960e-03 2.037 0 0
Gene expression (Transcription) R-HSA-74160 9.023729e-03 2.045 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 9.605436e-03 2.017 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.470329e-03 2.024 0 0
Signaling by EGFR R-HSA-177929 9.462456e-03 2.024 0 0
EPH-Ephrin signaling R-HSA-2682334 9.935968e-03 2.003 0 0
Regulation of Apoptosis R-HSA-169911 9.653490e-03 2.015 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 9.472248e-03 2.024 0 0
MAPK family signaling cascades R-HSA-5683057 9.751324e-03 2.011 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.007279e-02 1.997 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.027036e-02 1.988 0 0
Orc1 removal from chromatin R-HSA-68949 1.027036e-02 1.988 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.081387e-02 1.966 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.081387e-02 1.966 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.090762e-02 1.962 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.130572e-02 1.947 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.195510e-02 1.922 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.159077e-02 1.936 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.231375e-02 1.910 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.293206e-02 1.888 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.295232e-02 1.888 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.295232e-02 1.888 0 0
Ephrin signaling R-HSA-3928664 1.368331e-02 1.864 0 0
Translation initiation complex formation R-HSA-72649 1.385122e-02 1.859 0 0
Signaling by FGFR3 R-HSA-5654741 1.411294e-02 1.850 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.418153e-02 1.848 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.385122e-02 1.859 0 0
Signaling by NTRKs R-HSA-166520 1.467335e-02 1.833 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.484092e-02 1.829 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.511689e-02 1.821 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.634687e-02 1.787 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.597567e-02 1.797 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.670182e-02 1.777 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.670182e-02 1.777 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.670182e-02 1.777 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.670182e-02 1.777 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.670182e-02 1.777 0 0
Cellular Senescence R-HSA-2559583 1.695532e-02 1.771 0 0
Prolonged ERK activation events R-HSA-169893 1.730493e-02 1.762 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.774609e-02 1.751 0 0
Signaling by NOTCH2 R-HSA-1980145 1.774609e-02 1.751 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.834558e-02 1.736 0 0
NRAGE signals death through JNK R-HSA-193648 1.834558e-02 1.736 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.861746e-02 1.730 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.876203e-02 1.727 0 0
EGFR downregulation R-HSA-182971 1.898563e-02 1.722 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.904303e-02 1.720 0 0
Josephin domain DUBs R-HSA-5689877 2.009092e-02 1.697 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.071099e-02 1.684 0 0
Signaling by ALK R-HSA-201556 1.945889e-02 1.711 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.907750e-02 1.719 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.093380e-02 1.679 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.093380e-02 1.679 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.184955e-02 1.661 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.184955e-02 1.661 0 0
Disorders of Developmental Biology R-HSA-9675151 2.231348e-02 1.651 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.199532e-02 1.658 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.121376e-02 1.673 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.309187e-02 1.637 0 0
Ub-specific processing proteases R-HSA-5689880 2.203512e-02 1.657 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.270663e-02 1.644 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.270663e-02 1.644 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.184955e-02 1.661 0 0
HATs acetylate histones R-HSA-3214847 2.332123e-02 1.632 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.121376e-02 1.673 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.280039e-02 1.642 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.262079e-02 1.645 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.389059e-02 1.622 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.417596e-02 1.617 0 0
Cyclin D associated events in G1 R-HSA-69231 2.423888e-02 1.615 0 0
G1 Phase R-HSA-69236 2.423888e-02 1.615 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.423888e-02 1.615 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.765062e-02 1.558 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.765062e-02 1.558 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.765062e-02 1.558 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.765062e-02 1.558 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.765062e-02 1.558 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.765062e-02 1.558 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.765062e-02 1.558 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.765062e-02 1.558 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.765062e-02 1.558 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.765062e-02 1.558 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.765062e-02 1.558 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.748192e-02 1.561 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.748192e-02 1.561 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.748192e-02 1.561 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.728835e-02 1.564 0 0
RET signaling R-HSA-8853659 2.481856e-02 1.605 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.728835e-02 1.564 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.709985e-02 1.567 0 0
G2/M Transition R-HSA-69275 2.613526e-02 1.583 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.655288e-02 1.576 0 0
Degradation of CDH1 R-HSA-9766229 2.541306e-02 1.595 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.562847e-02 1.591 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.501273e-02 1.602 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.748192e-02 1.561 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.132357e-02 1.504 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.912806e-02 1.536 0 0
Late endosomal microautophagy R-HSA-9615710 2.912806e-02 1.536 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.171818e-02 1.499 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.172274e-02 1.499 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.132357e-02 1.504 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.132357e-02 1.504 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.795816e-02 1.553 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.837889e-02 1.547 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.074265e-02 1.512 0 0
Selective autophagy R-HSA-9663891 2.863516e-02 1.543 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.851775e-02 1.545 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.870294e-02 1.542 0 0
Degradation of DVL R-HSA-4641258 2.904813e-02 1.537 0 0
Signaling by Hippo R-HSA-2028269 2.826532e-02 1.549 0 0
Circadian clock R-HSA-9909396 2.815163e-02 1.550 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.851775e-02 1.545 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.826532e-02 1.549 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.171818e-02 1.499 0 0
RNA Polymerase II Transcription R-HSA-73857 3.179178e-02 1.498 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 4.192227e-02 1.378 0 0
Diseases of Telomere Maintenance R-HSA-9673013 4.192227e-02 1.378 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 4.192227e-02 1.378 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 4.192227e-02 1.378 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 4.192227e-02 1.378 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 4.192227e-02 1.378 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 4.192227e-02 1.378 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 4.192227e-02 1.378 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 4.192227e-02 1.378 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 4.192227e-02 1.378 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.183713e-02 1.378 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.183713e-02 1.378 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.426613e-02 1.465 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.662501e-02 1.331 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.662501e-02 1.331 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.662501e-02 1.331 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.647594e-02 1.438 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.647594e-02 1.438 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.644160e-02 1.438 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.644160e-02 1.438 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.523184e-02 1.453 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.747820e-02 1.426 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.442131e-02 1.352 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.063018e-02 1.391 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.304277e-02 1.366 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.903993e-02 1.408 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.756384e-02 1.425 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.756384e-02 1.425 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.390732e-02 1.470 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.242004e-02 1.372 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.242004e-02 1.372 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.293591e-02 1.367 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.485876e-02 1.458 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.323028e-02 1.364 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.323028e-02 1.364 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.903388e-02 1.409 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.334040e-02 1.363 0 0
ESR-mediated signaling R-HSA-8939211 4.459638e-02 1.351 0 0
RAF activation R-HSA-5673000 3.707605e-02 1.431 0 0
Signalling to ERKs R-HSA-187687 4.304277e-02 1.366 0 0
DNA Double Strand Break Response R-HSA-5693606 3.893119e-02 1.410 0 0
Mitophagy R-HSA-5205647 3.707605e-02 1.431 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.647594e-02 1.438 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.617943e-02 1.336 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.569397e-02 1.340 0 0
Signaling by FGFR4 R-HSA-5654743 4.053315e-02 1.392 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.747820e-02 1.426 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.977390e-02 1.400 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.304277e-02 1.366 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.442131e-02 1.352 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.673361e-02 1.330 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.183713e-02 1.378 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.304277e-02 1.366 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.304277e-02 1.366 0 0
Signaling by ROBO receptors R-HSA-376176 3.923834e-02 1.406 0 0
NGF-stimulated transcription R-HSA-9031628 4.163747e-02 1.381 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.044035e-02 1.393 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.377941e-02 1.471 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.341929e-02 1.476 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.053315e-02 1.392 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 3.867259e-02 1.413 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.593952e-02 1.338 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.593952e-02 1.338 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.447496e-02 1.462 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.242004e-02 1.372 0 0
G1/S Transition R-HSA-69206 3.423115e-02 1.466 0 0
L1CAM interactions R-HSA-373760 3.542267e-02 1.451 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.426613e-02 1.465 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.662501e-02 1.331 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.646890e-02 1.438 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.341929e-02 1.476 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.707605e-02 1.431 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.569397e-02 1.340 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.752091e-02 1.426 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.426613e-02 1.465 0 0
Stabilization of p53 R-HSA-69541 3.903993e-02 1.408 0 0
Maturation of protein E R-HSA-9683683 4.183713e-02 1.378 0 0
Maturation of protein E R-HSA-9694493 4.183713e-02 1.378 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.710644e-02 1.327 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.710644e-02 1.327 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.711976e-02 1.327 0 0
Disorders of Nervous System Development R-HSA-9697154 4.716348e-02 1.326 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.716348e-02 1.326 0 0
Pervasive developmental disorders R-HSA-9005895 4.716348e-02 1.326 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.716348e-02 1.326 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.716348e-02 1.326 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.716348e-02 1.326 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.716348e-02 1.326 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.716348e-02 1.326 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.716348e-02 1.326 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.716348e-02 1.326 0 0
Cilium Assembly R-HSA-5617833 4.804677e-02 1.318 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.809112e-02 1.318 0 0
S Phase R-HSA-69242 4.887116e-02 1.311 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.131138e-02 1.212 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.244110e-02 1.280 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.244110e-02 1.280 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.732267e-02 1.242 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.124751e-02 1.290 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.907298e-02 1.229 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.348063e-02 1.272 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.044405e-02 1.219 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.069186e-02 1.217 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.060857e-02 1.217 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.494793e-02 1.260 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.494793e-02 1.260 0 0
Integrin signaling R-HSA-354192 5.494793e-02 1.260 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.690665e-02 1.245 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.124751e-02 1.290 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.964436e-02 1.224 0 0
Frs2-mediated activation R-HSA-170968 5.960183e-02 1.225 0 0
Signaling by NOTCH3 R-HSA-9012852 5.344544e-02 1.272 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.951547e-02 1.225 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.230044e-02 1.281 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.823744e-02 1.235 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.252256e-02 1.280 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.321930e-02 1.274 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.079449e-02 1.294 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.871179e-02 1.231 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.010236e-02 1.300 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 5.951547e-02 1.225 0 0
Synthesis of DNA R-HSA-69239 5.180855e-02 1.286 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.076046e-02 1.216 0 0
Adherens junctions interactions R-HSA-418990 5.276034e-02 1.278 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.964890e-02 1.304 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.732267e-02 1.242 0 0
Neurodegenerative Diseases R-HSA-8863678 5.732267e-02 1.242 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.931511e-02 1.227 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.494793e-02 1.260 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.871179e-02 1.231 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.823744e-02 1.235 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.964520e-02 1.304 0 0
Degradation of AXIN R-HSA-4641257 5.690665e-02 1.245 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.690665e-02 1.245 0 0
Pexophagy R-HSA-9664873 6.131138e-02 1.212 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.358466e-02 1.271 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.427752e-02 1.265 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.494793e-02 1.260 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.964436e-02 1.224 0 0
Cell-Cell communication R-HSA-1500931 6.174314e-02 1.209 0 0
HIV Life Cycle R-HSA-162587 6.187833e-02 1.208 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.254179e-02 1.204 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.276914e-02 1.202 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.322916e-02 1.199 0 0
HIV Infection R-HSA-162906 6.363450e-02 1.196 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.458645e-02 1.190 0 0
Host Interactions of HIV factors R-HSA-162909 6.529901e-02 1.185 0 0
TCR signaling R-HSA-202403 6.538493e-02 1.185 0 0
Cell junction organization R-HSA-446728 6.589335e-02 1.181 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.591472e-02 1.181 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 6.648460e-02 1.177 0 0
HDMs demethylate histones R-HSA-3214842 6.724673e-02 1.172 0 0
Cell-cell junction organization R-HSA-421270 6.930177e-02 1.159 0 0
G alpha (12/13) signalling events R-HSA-416482 6.973351e-02 1.157 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.029417e-02 1.153 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.029417e-02 1.153 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 7.085194e-02 1.150 0 0
Death Receptor Signaling R-HSA-73887 7.205568e-02 1.142 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.228393e-02 1.141 0 0
Dual Incision in GG-NER R-HSA-5696400 7.228393e-02 1.141 0 0
Nuclear import of Rev protein R-HSA-180746 7.228393e-02 1.141 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.313579e-02 1.136 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 8.504635e-02 1.070 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 8.504635e-02 1.070 0 0
Regulation of gap junction activity R-HSA-191650 7.408217e-02 1.130 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 7.408217e-02 1.130 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 7.408217e-02 1.130 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 7.408217e-02 1.130 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 7.408217e-02 1.130 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 7.408217e-02 1.130 0 0
MECP2 regulates transcription factors R-HSA-9022707 8.008743e-02 1.096 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 8.008743e-02 1.096 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 8.008743e-02 1.096 0 0
PTK6 Expression R-HSA-8849473 8.008743e-02 1.096 0 0
Signaling by APC mutants R-HSA-4839744 7.832207e-02 1.106 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.832207e-02 1.106 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.832207e-02 1.106 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.832207e-02 1.106 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.979074e-02 1.047 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.979074e-02 1.047 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.428056e-02 1.129 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.014500e-02 1.045 0 0
Downstream signal transduction R-HSA-186763 8.066989e-02 1.093 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.066989e-02 1.093 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.066989e-02 1.093 0 0
Generation of second messenger molecules R-HSA-202433 8.281820e-02 1.082 0 0
Aggrephagy R-HSA-9646399 8.281820e-02 1.082 0 0
Centrosome maturation R-HSA-380287 8.458370e-02 1.073 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.511753e-02 1.022 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.058925e-02 1.043 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.281820e-02 1.082 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.818524e-02 1.107 0 0
Netrin-1 signaling R-HSA-373752 8.294346e-02 1.081 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.408430e-02 1.026 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.408430e-02 1.026 0 0
Interleukin-2 signaling R-HSA-9020558 7.832207e-02 1.106 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.245713e-02 1.034 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.711458e-02 1.060 0 0
Regulation of KIT signaling R-HSA-1433559 7.381427e-02 1.132 0 0
NF-kB is activated and signals survival R-HSA-209560 9.759677e-02 1.011 0 0
Budding and maturation of HIV virion R-HSA-162588 8.066989e-02 1.093 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.286400e-02 1.082 0 0
Autophagy R-HSA-9612973 8.126834e-02 1.090 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.394842e-02 1.131 0 0
Breakdown of the nuclear lamina R-HSA-352238 8.504635e-02 1.070 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.979074e-02 1.047 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.511753e-02 1.022 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 7.381427e-02 1.132 0 0
NRIF signals cell death from the nucleus R-HSA-205043 7.381427e-02 1.132 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.245713e-02 1.034 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.014500e-02 1.045 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 7.408217e-02 1.130 0 0
Signaling by AMER1 mutants R-HSA-4839748 9.759677e-02 1.011 0 0
Signaling by AXIN mutants R-HSA-4839735 9.759677e-02 1.011 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.185538e-02 1.087 0 0
Interaction between L1 and Ankyrins R-HSA-445095 9.014500e-02 1.045 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.348014e-02 1.134 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.245713e-02 1.034 0 0
MAP kinase activation R-HSA-450294 9.793283e-02 1.009 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 9.286686e-02 1.032 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.348014e-02 1.134 0 0
PKR-mediated signaling R-HSA-9833482 8.286400e-02 1.082 0 0
Hedgehog 'on' state R-HSA-5632684 9.408430e-02 1.026 0 0
Sensory processing of sound R-HSA-9659379 7.610909e-02 1.119 0 0
Nucleotide Excision Repair R-HSA-5696398 9.871374e-02 1.006 0 0
Signal Transduction R-HSA-162582 9.918179e-02 1.004 1 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.960595e-02 1.002 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.008724e-01 0.996 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.012744e-01 0.995 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.026170e-01 0.989 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.026170e-01 0.989 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.026170e-01 0.989 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.026170e-01 0.989 0 0
Signaling by RAS mutants R-HSA-6802949 1.026170e-01 0.989 0 0
PTEN Regulation R-HSA-6807070 1.030856e-01 0.987 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.031226e-01 0.987 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.036275e-01 0.985 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.036275e-01 0.985 0 0
Formation of annular gap junctions R-HSA-196025 1.039654e-01 0.983 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.039654e-01 0.983 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.040973e-01 0.983 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.040973e-01 0.983 0 0
Nuclear RNA decay R-HSA-9930044 1.040973e-01 0.983 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.041801e-01 0.982 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.041801e-01 0.982 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.045081e-01 0.981 0 0
NrCAM interactions R-HSA-447038 1.049894e-01 0.979 0 0
Activation of AKT2 R-HSA-165158 1.049894e-01 0.979 0 0
IRS activation R-HSA-74713 1.049894e-01 0.979 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.049894e-01 0.979 0 0
PTK6 Activates STAT3 R-HSA-8849474 1.049894e-01 0.979 0 0
Phosphorylation of the APC/C R-HSA-176412 1.074895e-01 0.969 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.074895e-01 0.969 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.137527e-01 0.944 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.139254e-01 0.943 0 0
MTOR signalling R-HSA-165159 1.150968e-01 0.939 0 0
Macroautophagy R-HSA-1632852 1.156135e-01 0.937 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.159272e-01 0.936 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.163900e-01 0.934 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.169442e-01 0.932 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.171045e-01 0.931 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.171045e-01 0.931 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.171386e-01 0.931 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.171386e-01 0.931 0 0
Signaling by NOTCH R-HSA-157118 1.183412e-01 0.927 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.190247e-01 0.924 0 0
Repression of WNT target genes R-HSA-4641265 1.190247e-01 0.924 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 1.190247e-01 0.924 0 0
Signaling by LTK R-HSA-9842663 1.190247e-01 0.924 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.190247e-01 0.924 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.190247e-01 0.924 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.190247e-01 0.924 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.190247e-01 0.924 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.224496e-01 0.912 0 0
Vesicle-mediated transport R-HSA-5653656 1.236756e-01 0.908 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.242694e-01 0.906 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.242694e-01 0.906 0 0
Signaling by MET R-HSA-6806834 1.260993e-01 0.899 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.268400e-01 0.897 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.268400e-01 0.897 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.268400e-01 0.897 0 0
TBC/RABGAPs R-HSA-8854214 1.272665e-01 0.895 0 0
Defective Base Excision Repair Associated with NEIL1 R-HSA-9616334 1.486814e-01 0.828 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.486814e-01 0.828 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.486814e-01 0.828 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.486814e-01 0.828 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.486814e-01 0.828 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.486814e-01 0.828 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.486814e-01 0.828 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.486814e-01 0.828 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.365279e-01 0.865 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.400263e-01 0.854 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 1.400263e-01 0.854 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.306745e-01 0.884 0 0
ARMS-mediated activation R-HSA-170984 1.306745e-01 0.884 0 0
Lipophagy R-HSA-9613354 1.306745e-01 0.884 0 0
Gap junction degradation R-HSA-190873 1.306745e-01 0.884 0 0
Erythropoietin activates STAT5 R-HSA-9027283 1.783459e-01 0.749 0 0
G2/M DNA replication checkpoint R-HSA-69478 1.783459e-01 0.749 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.783459e-01 0.749 0 0
Signal attenuation R-HSA-74749 1.598783e-01 0.796 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.598783e-01 0.796 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.424527e-01 0.846 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.676932e-01 0.775 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.477458e-01 0.830 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.477458e-01 0.830 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.477458e-01 0.830 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.700888e-01 0.769 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.495737e-01 0.825 0 0
DAP12 signaling R-HSA-2424491 1.320675e-01 0.879 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.676970e-01 0.775 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.676970e-01 0.775 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.676970e-01 0.775 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.293742e-01 0.888 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.869677e-01 0.728 0 0
HIV elongation arrest and recovery R-HSA-167287 1.869677e-01 0.728 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.869677e-01 0.728 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.431152e-01 0.844 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.776855e-01 0.750 0 0
HDACs deacetylate histones R-HSA-3214815 1.455843e-01 0.837 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.298421e-01 0.887 0 0
Dual incision in TC-NER R-HSA-6782135 1.846892e-01 0.734 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.344147e-01 0.872 0 0
Protein folding R-HSA-391251 1.557312e-01 0.808 0 0
Post NMDA receptor activation events R-HSA-438064 1.508532e-01 0.821 0 0
Mismatch Repair R-HSA-5358508 1.700888e-01 0.769 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.306668e-01 0.884 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.477458e-01 0.830 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.456976e-01 0.837 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.276327e-01 0.894 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.727695e-01 0.763 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.442382e-01 0.841 0 0
Neurexins and neuroligins R-HSA-6794361 1.767859e-01 0.753 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.598783e-01 0.796 0 0
Regulation of TP53 Expression R-HSA-6804754 1.365279e-01 0.865 0 0
Interleukin-6 signaling R-HSA-1059683 1.424527e-01 0.846 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.536508e-01 0.813 0 0
Myogenesis R-HSA-525793 1.493906e-01 0.826 0 0
Recycling pathway of L1 R-HSA-437239 1.826231e-01 0.738 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.487325e-01 0.828 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.506095e-01 0.822 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.668683e-01 0.778 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.336728e-01 0.874 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.479788e-01 0.830 0 0
Signaling by FGFR1 R-HSA-5654736 1.580844e-01 0.801 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.826231e-01 0.738 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.423063e-01 0.847 0 0
Signaling by WNT in cancer R-HSA-4791275 1.647972e-01 0.783 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.477458e-01 0.830 0 0
Nef and signal transduction R-HSA-164944 1.783459e-01 0.749 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.696786e-01 0.770 0 0
Cellular response to hypoxia R-HSA-1234174 1.375829e-01 0.861 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.786013e-01 0.748 0 0
Semaphorin interactions R-HSA-373755 1.784415e-01 0.749 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.892604e-01 0.723 0 0
Rab regulation of trafficking R-HSA-9007101 1.662261e-01 0.779 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.306745e-01 0.884 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.424527e-01 0.846 0 0
Glycogen storage diseases R-HSA-3229121 1.477458e-01 0.830 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.700888e-01 0.769 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.431152e-01 0.844 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.493906e-01 0.826 0 0
Hedgehog 'off' state R-HSA-5610787 1.911538e-01 0.719 0 0
PECAM1 interactions R-HSA-210990 1.912012e-01 0.719 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.627042e-01 0.789 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.702338e-01 0.769 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.702338e-01 0.769 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.702338e-01 0.769 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.676932e-01 0.775 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.401236e-01 0.853 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.784415e-01 0.749 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.431152e-01 0.844 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.460977e-01 0.835 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.700888e-01 0.769 0 0
Signaling by Leptin R-HSA-2586552 1.598783e-01 0.796 0 0
Assembly Of The HIV Virion R-HSA-175474 1.495737e-01 0.825 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.536508e-01 0.813 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.536508e-01 0.813 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.580844e-01 0.801 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.918545e-01 0.717 0 0
TRKA activation by NGF R-HSA-187042 1.929302e-01 0.715 0 0
PLC-gamma1 signalling R-HSA-167021 1.929302e-01 0.715 0 0
MET interacts with TNS proteins R-HSA-8875513 1.929302e-01 0.715 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 1.929302e-01 0.715 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.929302e-01 0.715 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.929302e-01 0.715 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.929302e-01 0.715 0 0
Inhibition of nitric oxide production R-HSA-9636249 1.929302e-01 0.715 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.937327e-01 0.713 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.937327e-01 0.713 0 0
Erythropoietin activates RAS R-HSA-9027284 1.945332e-01 0.711 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.945332e-01 0.711 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.945332e-01 0.711 0 0
Protein methylation R-HSA-8876725 1.945332e-01 0.711 0 0
p75NTR signals via NF-kB R-HSA-193639 1.945332e-01 0.711 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.945332e-01 0.711 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.945332e-01 0.711 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.949388e-01 0.710 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.979781e-01 0.703 0 0
Interleukin-17 signaling R-HSA-448424 1.979781e-01 0.703 0 0
Metabolism of non-coding RNA R-HSA-194441 1.987528e-01 0.702 0 0
snRNP Assembly R-HSA-191859 1.987528e-01 0.702 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.051069e-01 0.688 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.071271e-01 0.684 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.090250e-01 0.680 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.090250e-01 0.680 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.098464e-01 0.678 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.752638e-01 0.560 0 0
MGMT-mediated DNA damage reversal R-HSA-5657655 2.752638e-01 0.560 0 0
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) R-HSA-5619110 2.752638e-01 0.560 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.752638e-01 0.560 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.752638e-01 0.560 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.516535e-01 0.599 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.516535e-01 0.599 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.516535e-01 0.599 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.516535e-01 0.599 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 3.830309e-01 0.417 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.830309e-01 0.417 0 0
t(4;14) translocations of FGFR3 R-HSA-2033515 3.830309e-01 0.417 0 0
Signaling by FGFR3 fusions in cancer R-HSA-8853334 3.830309e-01 0.417 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.830309e-01 0.417 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.830309e-01 0.417 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.830309e-01 0.417 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.830309e-01 0.417 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.830309e-01 0.417 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.830309e-01 0.417 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.830309e-01 0.417 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.830309e-01 0.417 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.830309e-01 0.417 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.830309e-01 0.417 0 0
Disinhibition of SNARE formation R-HSA-114516 2.191038e-01 0.659 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.191038e-01 0.659 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.191038e-01 0.659 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.107614e-01 0.508 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.107614e-01 0.508 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.614991e-01 0.583 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.614991e-01 0.583 0 0
MET receptor recycling R-HSA-8875656 2.614991e-01 0.583 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.614991e-01 0.583 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.614991e-01 0.583 0 0
Activation of RAC1 R-HSA-428540 2.242469e-01 0.649 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.227417e-01 0.652 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.586152e-01 0.587 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.586152e-01 0.587 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.586152e-01 0.587 0 0
Regulation of IFNG signaling R-HSA-877312 2.586152e-01 0.587 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.586152e-01 0.587 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.048008e-01 0.516 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.048008e-01 0.516 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.048008e-01 0.516 0 0
ALK mutants bind TKIs R-HSA-9700645 3.048008e-01 0.516 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.688420e-01 0.433 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.688420e-01 0.433 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.688420e-01 0.433 0 0
Cam-PDE 1 activation R-HSA-111957 3.688420e-01 0.433 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.688420e-01 0.433 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.688420e-01 0.433 0 0
Signaling by MAPK mutants R-HSA-9652817 3.688420e-01 0.433 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.520780e-01 0.598 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.520780e-01 0.598 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.939141e-01 0.532 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.130982e-01 0.671 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.483612e-01 0.458 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.483612e-01 0.458 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.483612e-01 0.458 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.483612e-01 0.458 0 0
Long-term potentiation R-HSA-9620244 2.361958e-01 0.627 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.709236e-01 0.567 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.709236e-01 0.567 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.709236e-01 0.567 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.297707e-01 0.482 0 0
PKA activation R-HSA-163615 3.131580e-01 0.504 0 0
PERK regulates gene expression R-HSA-381042 2.400540e-01 0.620 0 0
DCC mediated attractive signaling R-HSA-418885 3.658377e-01 0.437 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.658377e-01 0.437 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.658377e-01 0.437 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.444247e-01 0.463 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.444247e-01 0.463 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.132922e-01 0.671 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.949137e-01 0.530 0 0
MAP2K and MAPK activation R-HSA-5674135 2.692779e-01 0.570 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.579321e-01 0.588 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.375248e-01 0.624 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.765018e-01 0.558 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.891877e-01 0.539 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.891877e-01 0.539 0 0
MET promotes cell motility R-HSA-8875878 3.030029e-01 0.519 0 0
Signaling by Erythropoietin R-HSA-9006335 3.350283e-01 0.475 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.350283e-01 0.475 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.758739e-01 0.425 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.758739e-01 0.425 0 0
Translesion synthesis by POLI R-HSA-5656121 4.017990e-01 0.396 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.017990e-01 0.396 0 0
Meiotic synapsis R-HSA-1221632 2.825615e-01 0.549 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.825615e-01 0.549 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.954656e-01 0.529 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.248236e-01 0.488 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.417714e-01 0.466 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.132999e-01 0.671 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.607231e-01 0.443 0 0
Activation of the pre-replicative complex R-HSA-68962 3.607231e-01 0.443 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.607231e-01 0.443 0 0
Protein ubiquitination R-HSA-8852135 2.686849e-01 0.571 0 0
HIV Transcription Elongation R-HSA-167169 3.469311e-01 0.460 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.469311e-01 0.460 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.469311e-01 0.460 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.365866e-01 0.626 0 0
Nucleosome assembly R-HSA-774815 3.509657e-01 0.455 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.509657e-01 0.455 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.121009e-01 0.506 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.895670e-01 0.409 0 0
Transcription of the HIV genome R-HSA-167172 3.431139e-01 0.465 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.916910e-01 0.407 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.991073e-01 0.524 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.991073e-01 0.524 0 0
Ribosome-associated quality control R-HSA-9948299 2.955365e-01 0.529 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.652159e-01 0.437 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.430117e-01 0.465 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.128710e-01 0.384 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.132999e-01 0.671 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.607231e-01 0.443 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.777133e-01 0.556 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.901508e-01 0.537 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.954436e-01 0.403 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.777133e-01 0.556 0 0
IGF1R signaling cascade R-HSA-2428924 3.770814e-01 0.424 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.483612e-01 0.458 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.607231e-01 0.443 0 0
DARPP-32 events R-HSA-180024 3.350283e-01 0.475 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.540211e-01 0.451 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.787988e-01 0.422 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.105136e-01 0.387 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.822974e-01 0.549 0 0
DNA Damage Bypass R-HSA-73893 2.139601e-01 0.670 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 2.939141e-01 0.532 0 0
CaM pathway R-HSA-111997 2.605397e-01 0.584 0 0
Translesion Synthesis by POLH R-HSA-110320 3.444247e-01 0.463 0 0
Calmodulin induced events R-HSA-111933 2.605397e-01 0.584 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 3.107614e-01 0.508 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 2.124948e-01 0.673 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.498178e-01 0.602 0 0
RNA Polymerase I Transcription R-HSA-73864 3.148863e-01 0.502 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.579321e-01 0.588 0 0
GPVI-mediated activation cascade R-HSA-114604 2.605397e-01 0.584 0 0
Signaling by FGFR2 R-HSA-5654738 3.468053e-01 0.460 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.871821e-01 0.542 0 0
Homology Directed Repair R-HSA-5693538 3.798568e-01 0.420 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.107614e-01 0.508 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.048008e-01 0.516 0 0
PI3K/AKT activation R-HSA-198203 3.483612e-01 0.458 0 0
Translesion synthesis by REV1 R-HSA-110312 3.658377e-01 0.437 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.949137e-01 0.530 0 0
Signalling to RAS R-HSA-167044 4.072961e-01 0.390 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.800226e-01 0.420 0 0
DAG and IP3 signaling R-HSA-1489509 3.509657e-01 0.455 0 0
Interleukin-2 family signaling R-HSA-451927 2.308701e-01 0.637 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.407174e-01 0.468 0 0
Ca-dependent events R-HSA-111996 4.141893e-01 0.383 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.840276e-01 0.416 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.468053e-01 0.460 0 0
FOXO-mediated transcription R-HSA-9614085 4.101666e-01 0.387 0 0
TNF signaling R-HSA-75893 2.375248e-01 0.624 0 0
DNA Replication R-HSA-69306 2.190880e-01 0.659 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.822614e-01 0.418 0 0
TGFBR3 expression R-HSA-9839394 3.822614e-01 0.418 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.429899e-01 0.465 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.949137e-01 0.530 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.915331e-01 0.535 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.618936e-01 0.441 0 0
DNA Repair R-HSA-73894 2.416463e-01 0.617 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.213075e-01 0.655 0 0
Co-inhibition by PD-1 R-HSA-389948 3.428207e-01 0.465 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.688420e-01 0.433 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.822974e-01 0.549 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.201670e-01 0.657 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.258875e-01 0.487 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.899632e-01 0.409 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.206722e-01 0.376 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.513806e-01 0.600 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.520780e-01 0.598 0 0
ER-Phagosome pathway R-HSA-1236974 3.194094e-01 0.496 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.513806e-01 0.600 0 0
Signaling by WNT R-HSA-195721 3.644022e-01 0.438 0 0
Signaling by SCF-KIT R-HSA-1433557 3.094828e-01 0.509 0 0
Regulation of beta-cell development R-HSA-186712 3.949807e-01 0.403 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.048008e-01 0.516 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.688420e-01 0.433 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.934057e-01 0.405 0 0
Glycogen synthesis R-HSA-3322077 2.185275e-01 0.660 0 0
Glycogen metabolism R-HSA-8982491 3.469311e-01 0.460 0 0
Oncogene Induced Senescence R-HSA-2559585 3.655999e-01 0.437 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.934057e-01 0.405 0 0
ERK/MAPK targets R-HSA-198753 2.443131e-01 0.612 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.297707e-01 0.482 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.072961e-01 0.390 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.618296e-01 0.582 0 0
Generic Transcription Pathway R-HSA-212436 3.356480e-01 0.474 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.201670e-01 0.657 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.949137e-01 0.530 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.113737e-01 0.675 0 0
RMTs methylate histone arginines R-HSA-3214858 2.221848e-01 0.653 0 0
Signal transduction by L1 R-HSA-445144 3.758739e-01 0.425 0 0
Biotin transport and metabolism R-HSA-196780 3.658377e-01 0.437 0 0
Signaling by ERBB4 R-HSA-1236394 3.451200e-01 0.462 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.132922e-01 0.671 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.228000e-01 0.491 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.516535e-01 0.599 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.516535e-01 0.599 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.830309e-01 0.417 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.830309e-01 0.417 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.830309e-01 0.417 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.830309e-01 0.417 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.830309e-01 0.417 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 3.830309e-01 0.417 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.048008e-01 0.516 0 0
Unwinding of DNA R-HSA-176974 3.048008e-01 0.516 0 0
Proton/oligopeptide cotransporters R-HSA-427975 3.688420e-01 0.433 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.688420e-01 0.433 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.520780e-01 0.598 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.916219e-01 0.407 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.444247e-01 0.463 0 0
Kinesins R-HSA-983189 3.051153e-01 0.516 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.509657e-01 0.455 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.588253e-01 0.445 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.109010e-01 0.386 0 0
Muscle contraction R-HSA-397014 4.143855e-01 0.383 1 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.986393e-01 0.399 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.124948e-01 0.673 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.280185e-01 0.642 0 0
Somitogenesis R-HSA-9824272 3.509657e-01 0.455 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.051153e-01 0.516 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.981900e-01 0.526 0 0
Diseases of programmed cell death R-HSA-9645723 3.956334e-01 0.403 0 0
Heme signaling R-HSA-9707616 2.436883e-01 0.613 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.094828e-01 0.509 0 0
tRNA processing in the nucleus R-HSA-6784531 3.407174e-01 0.468 0 0
Adrenoceptors R-HSA-390696 2.614991e-01 0.583 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.865674e-01 0.413 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.770814e-01 0.424 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.765018e-01 0.558 0 0
RUNX2 regulates bone development R-HSA-8941326 2.605397e-01 0.584 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.579321e-01 0.588 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.395764e-01 0.621 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.541673e-01 0.451 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.350283e-01 0.475 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.144358e-01 0.383 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.647735e-01 0.577 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.483612e-01 0.458 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.800049e-01 0.553 0 0
Interleukin-1 signaling R-HSA-9020702 2.709614e-01 0.567 0 0
Inhibition of membrane repair R-HSA-9635644 3.830309e-01 0.417 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.830309e-01 0.417 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 3.107614e-01 0.508 0 0
TRAIL signaling R-HSA-75158 3.688420e-01 0.433 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.520780e-01 0.598 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 2.720802e-01 0.565 0 0
PCP/CE pathway R-HSA-4086400 3.148863e-01 0.502 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.144224e-01 0.383 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.509657e-01 0.455 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 2.939141e-01 0.532 0 0
Signal regulatory protein family interactions R-HSA-391160 3.297707e-01 0.482 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.600618e-01 0.585 0 0
CASP4 inflammasome assembly R-HSA-9948001 3.483612e-01 0.458 0 0
Growth hormone receptor signaling R-HSA-982772 3.259442e-01 0.487 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 4.072961e-01 0.390 0 0
Inositol phosphate metabolism R-HSA-1483249 3.525396e-01 0.453 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.586152e-01 0.587 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.586152e-01 0.587 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.498178e-01 0.602 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.741563e-01 0.427 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.444247e-01 0.463 0 0
Basigin interactions R-HSA-210991 4.072961e-01 0.390 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.916219e-01 0.407 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.714593e-01 0.566 0 0
Response to metal ions R-HSA-5660526 2.520780e-01 0.598 0 0
Regulation of BACH1 activity R-HSA-9708530 4.017990e-01 0.396 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.248944e-01 0.372 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 4.248944e-01 0.372 0 0
CREB phosphorylation R-HSA-199920 4.248944e-01 0.372 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 4.248944e-01 0.372 0 0
Neurofascin interactions R-HSA-447043 4.248944e-01 0.372 0 0
Meiosis R-HSA-1500620 4.287905e-01 0.368 0 0
Signaling by Interleukins R-HSA-449147 4.337434e-01 0.363 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.341141e-01 0.362 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.341141e-01 0.362 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.341141e-01 0.362 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.341141e-01 0.362 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.343564e-01 0.362 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.343564e-01 0.362 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.373724e-01 0.359 0 0
Translesion synthesis by POLK R-HSA-5655862 4.373724e-01 0.359 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 4.373724e-01 0.359 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.382448e-01 0.358 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.384983e-01 0.358 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.384983e-01 0.358 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.386351e-01 0.358 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.386351e-01 0.358 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.386351e-01 0.358 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.386351e-01 0.358 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.386351e-01 0.358 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.419816e-01 0.355 0 0
Signaling by Hedgehog R-HSA-5358351 4.430337e-01 0.354 0 0
Regulated Necrosis R-HSA-5218859 4.507538e-01 0.346 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.575216e-01 0.340 0 0
Proteasome assembly R-HSA-9907900 4.590551e-01 0.338 0 0
DAP12 interactions R-HSA-2172127 4.590551e-01 0.338 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.641443e-01 0.333 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.664941e-01 0.331 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.664941e-01 0.331 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.664941e-01 0.331 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.682383e-01 0.330 0 0
Antigen processing-Cross presentation R-HSA-1236975 4.682383e-01 0.330 0 0
Leishmania phagocytosis R-HSA-9664417 4.687491e-01 0.329 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.687491e-01 0.329 0 0
Parasite infection R-HSA-9664407 4.687491e-01 0.329 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 4.693056e-01 0.329 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.693056e-01 0.329 0 0
mTORC1-mediated signalling R-HSA-166208 4.693056e-01 0.329 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 4.693056e-01 0.329 0 0
Specification of primordial germ cells R-HSA-9827857 4.723111e-01 0.326 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.747785e-01 0.324 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 4.747785e-01 0.324 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 4.747785e-01 0.324 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.747785e-01 0.324 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.747785e-01 0.324 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.747785e-01 0.324 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.747785e-01 0.324 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.747785e-01 0.324 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.747785e-01 0.324 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.747785e-01 0.324 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.747785e-01 0.324 0 0
Diseases of Cellular Senescence R-HSA-9630747 4.747785e-01 0.324 0 0
Diseases of cellular response to stress R-HSA-9675132 4.747785e-01 0.324 0 0
DSCAM interactions R-HSA-376172 4.747785e-01 0.324 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.747785e-01 0.324 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.747785e-01 0.324 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.754548e-01 0.323 0 0
Interleukin-15 signaling R-HSA-8983432 4.754548e-01 0.323 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.754548e-01 0.323 0 0
Activation of TRKA receptors R-HSA-187015 4.782378e-01 0.320 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.782378e-01 0.320 0 0
Netrin mediated repulsion signals R-HSA-418886 4.782378e-01 0.320 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.782378e-01 0.320 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.782378e-01 0.320 0 0
SOS-mediated signalling R-HSA-112412 4.782378e-01 0.320 0 0
Recycling of eIF2:GDP R-HSA-72731 4.782378e-01 0.320 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.782378e-01 0.320 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 4.782378e-01 0.320 0 0
CHL1 interactions R-HSA-447041 4.782378e-01 0.320 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 4.782378e-01 0.320 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.782378e-01 0.320 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.850255e-01 0.314 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.861969e-01 0.313 0 0
Signaling by FGFR R-HSA-190236 4.884840e-01 0.311 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.892043e-01 0.311 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.892043e-01 0.311 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.939700e-01 0.306 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.939700e-01 0.306 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.939700e-01 0.306 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.945598e-01 0.306 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.980711e-01 0.303 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.987567e-01 0.302 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.995622e-01 0.301 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.995622e-01 0.301 0 0
Syndecan interactions R-HSA-3000170 4.995622e-01 0.301 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.995622e-01 0.301 0 0
Adipogenesis R-HSA-9843745 4.997709e-01 0.301 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.032942e-01 0.298 0 0
Diseases of DNA repair R-HSA-9675135 5.032942e-01 0.298 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.043518e-01 0.297 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.064037e-01 0.296 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.064037e-01 0.296 0 0
Platelet sensitization by LDL R-HSA-432142 5.064037e-01 0.296 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.083782e-01 0.294 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.097743e-01 0.293 0 0
FGFR3 mutant receptor activation R-HSA-2033514 5.153403e-01 0.288 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 5.153403e-01 0.288 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 5.153403e-01 0.288 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.153403e-01 0.288 0 0
Processing of SMDT1 R-HSA-8949664 5.153403e-01 0.288 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.153403e-01 0.288 0 0
Gastrulation R-HSA-9758941 5.168190e-01 0.287 0 0
ABC transporter disorders R-HSA-5619084 5.190527e-01 0.285 0 0
Glycolysis R-HSA-70171 5.191407e-01 0.285 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.209542e-01 0.283 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.209542e-01 0.283 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.235648e-01 0.281 0 0
Downstream TCR signaling R-HSA-202424 5.271219e-01 0.278 0 0
Type I hemidesmosome assembly R-HSA-446107 5.284384e-01 0.277 0 0
RSK activation R-HSA-444257 5.284384e-01 0.277 0 0
Regulation by c-FLIP R-HSA-3371378 5.284384e-01 0.277 0 0
Dimerization of procaspase-8 R-HSA-69416 5.284384e-01 0.277 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 5.284384e-01 0.277 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 5.284384e-01 0.277 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.284384e-01 0.277 0 0
Deadenylation of mRNA R-HSA-429947 5.291316e-01 0.276 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.291316e-01 0.276 0 0
Interleukin-6 family signaling R-HSA-6783589 5.291316e-01 0.276 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.385725e-01 0.269 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.387049e-01 0.269 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.387049e-01 0.269 0 0
RNA Polymerase III Transcription R-HSA-74158 5.387049e-01 0.269 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.394737e-01 0.268 0 0
The NLRP3 inflammasome R-HSA-844456 5.394737e-01 0.268 0 0
Other interleukin signaling R-HSA-449836 5.394737e-01 0.268 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.473502e-01 0.262 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.528870e-01 0.257 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.528870e-01 0.257 0 0
Invadopodia formation R-HSA-8941237 5.528870e-01 0.257 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.528870e-01 0.257 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 5.528870e-01 0.257 0 0
Defective ABCC2 causes DJS R-HSA-5679001 5.528870e-01 0.257 0 0
Signalling to STAT3 R-HSA-198745 5.528870e-01 0.257 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 5.528870e-01 0.257 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 5.528870e-01 0.257 0 0
MET activates PTPN11 R-HSA-8865999 5.528870e-01 0.257 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 5.528870e-01 0.257 0 0
MET activates STAT3 R-HSA-8875791 5.528870e-01 0.257 0 0
Histamine receptors R-HSA-390650 5.528870e-01 0.257 0 0
FasL/ CD95L signaling R-HSA-75157 5.528870e-01 0.257 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.530428e-01 0.257 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 5.535392e-01 0.257 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.535392e-01 0.257 0 0
Tight junction interactions R-HSA-420029 5.578965e-01 0.253 0 0
Interleukin-7 signaling R-HSA-1266695 5.578965e-01 0.253 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.611926e-01 0.251 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 5.674312e-01 0.246 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.700227e-01 0.244 0 0
Amyloid fiber formation R-HSA-977225 5.700227e-01 0.244 0 0
Formation of definitive endoderm R-HSA-9823730 5.713775e-01 0.243 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.713775e-01 0.243 0 0
Signaling by PDGF R-HSA-186797 5.719461e-01 0.243 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.719461e-01 0.243 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.719461e-01 0.243 0 0
Interleukin-21 signaling R-HSA-9020958 5.752514e-01 0.240 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.752514e-01 0.240 0 0
Calcineurin activates NFAT R-HSA-2025928 5.752514e-01 0.240 0 0
CASP8 activity is inhibited R-HSA-5218900 5.752514e-01 0.240 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 5.752514e-01 0.240 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 5.752514e-01 0.240 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.752514e-01 0.240 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.752514e-01 0.240 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.830377e-01 0.234 0 0
MET activates PTK2 signaling R-HSA-8874081 5.857583e-01 0.232 0 0
TRP channels R-HSA-3295583 5.857583e-01 0.232 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.894915e-01 0.230 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.898837e-01 0.229 0 0
Formation of the anterior neural plate R-HSA-9823739 5.898837e-01 0.229 0 0
Interleukin-12 signaling R-HSA-9020591 5.932788e-01 0.227 0 0
G-protein beta:gamma signalling R-HSA-397795 5.980531e-01 0.223 0 0
Cardiogenesis R-HSA-9733709 5.980531e-01 0.223 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.007621e-01 0.221 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.017940e-01 0.221 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 6.020022e-01 0.220 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.020022e-01 0.220 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.020022e-01 0.220 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.020022e-01 0.220 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.089222e-01 0.215 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.126365e-01 0.213 0 0
2-LTR circle formation R-HSA-164843 6.185741e-01 0.209 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.185741e-01 0.209 0 0
Interleukin-27 signaling R-HSA-9020956 6.185741e-01 0.209 0 0
MAPK3 (ERK1) activation R-HSA-110056 6.185741e-01 0.209 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.185741e-01 0.209 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 6.185741e-01 0.209 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.185741e-01 0.209 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 6.193834e-01 0.208 0 0
Signaling by MAP2K mutants R-HSA-9652169 6.193834e-01 0.208 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 6.193834e-01 0.208 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 6.193834e-01 0.208 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 6.193834e-01 0.208 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 6.193834e-01 0.208 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.193834e-01 0.208 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.201118e-01 0.208 0 0
Mitochondrial biogenesis R-HSA-1592230 6.235295e-01 0.205 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.242616e-01 0.205 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.242616e-01 0.205 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.242616e-01 0.205 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.242616e-01 0.205 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.310228e-01 0.200 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.310228e-01 0.200 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.310228e-01 0.200 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.312633e-01 0.200 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.360795e-01 0.196 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.384675e-01 0.195 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.384675e-01 0.195 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.455477e-01 0.190 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.455477e-01 0.190 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.459742e-01 0.190 0 0
Toll-like Receptor Cascades R-HSA-168898 6.460458e-01 0.190 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.560897e-01 0.183 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.560897e-01 0.183 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.560897e-01 0.183 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.566080e-01 0.183 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.566080e-01 0.183 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.566080e-01 0.183 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.566497e-01 0.183 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.566538e-01 0.183 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 6.584091e-01 0.182 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 6.584091e-01 0.182 0 0
Formation of the posterior neural plate R-HSA-9832991 6.584091e-01 0.182 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 6.584091e-01 0.182 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 6.584091e-01 0.182 0 0
Suppression of apoptosis R-HSA-9635465 6.584091e-01 0.182 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 6.591021e-01 0.181 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.591021e-01 0.181 0 0
Signaling by KIT in disease R-HSA-9669938 6.591021e-01 0.181 0 0
DNA methylation R-HSA-5334118 6.632035e-01 0.178 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.653629e-01 0.177 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.714161e-01 0.173 0 0
PLC beta mediated events R-HSA-112043 6.714161e-01 0.173 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.730196e-01 0.172 0 0
HIV Transcription Initiation R-HSA-167161 6.730196e-01 0.172 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.730196e-01 0.172 0 0
Intra-Golgi traffic R-HSA-6811438 6.730196e-01 0.172 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.730196e-01 0.172 0 0
PTK6 Down-Regulation R-HSA-8849472 6.759934e-01 0.170 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.759934e-01 0.170 0 0
G2 Phase R-HSA-68911 6.759934e-01 0.170 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.759934e-01 0.170 0 0
Defective F9 activation R-HSA-9673221 6.759934e-01 0.170 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.759934e-01 0.170 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.759934e-01 0.170 0 0
Reelin signalling pathway R-HSA-8866376 6.759934e-01 0.170 0 0
Suppression of autophagy R-HSA-9636569 6.759934e-01 0.170 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.759934e-01 0.170 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.759934e-01 0.170 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.759934e-01 0.170 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.759934e-01 0.170 0 0
GPER1 signaling R-HSA-9634597 6.781465e-01 0.169 0 0
Interleukin-12 family signaling R-HSA-447115 6.793435e-01 0.168 0 0
Interleukin-20 family signaling R-HSA-8854691 6.854824e-01 0.164 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.868979e-01 0.163 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.868979e-01 0.163 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.868979e-01 0.163 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.868979e-01 0.163 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.868979e-01 0.163 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.868979e-01 0.163 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.883066e-01 0.162 0 0
FLT3 signaling in disease R-HSA-9682385 6.894818e-01 0.161 0 0
G1/S-Specific Transcription R-HSA-69205 6.894818e-01 0.161 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.948356e-01 0.158 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.948356e-01 0.158 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.948356e-01 0.158 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 6.948356e-01 0.158 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.948356e-01 0.158 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.948356e-01 0.158 0 0
Integration of provirus R-HSA-162592 6.948356e-01 0.158 0 0
ERKs are inactivated R-HSA-202670 6.948356e-01 0.158 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.948356e-01 0.158 0 0
Gap junction trafficking and regulation R-HSA-157858 6.966230e-01 0.157 0 0
Interleukin-1 family signaling R-HSA-446652 7.013287e-01 0.154 0 0
ABC-family proteins mediated transport R-HSA-382556 7.035765e-01 0.153 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.046576e-01 0.152 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.119038e-01 0.148 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.119707e-01 0.148 0 0
PI3K Cascade R-HSA-109704 7.144067e-01 0.146 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.151391e-01 0.146 0 0
PKA activation in glucagon signalling R-HSA-164378 7.151391e-01 0.146 0 0
GAB1 signalosome R-HSA-180292 7.151391e-01 0.146 0 0
Transport of connexons to the plasma membrane R-HSA-190872 7.151391e-01 0.146 0 0
Polo-like kinase mediated events R-HSA-156711 7.151391e-01 0.146 0 0
Tie2 Signaling R-HSA-210993 7.151391e-01 0.146 0 0
Signaling by TGFB family members R-HSA-9006936 7.163213e-01 0.145 0 0
Insulin receptor signalling cascade R-HSA-74751 7.204575e-01 0.142 0 0
NGF-independant TRKA activation R-HSA-187024 7.241865e-01 0.140 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.241865e-01 0.140 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.241865e-01 0.140 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.241865e-01 0.140 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 7.241865e-01 0.140 0 0
Signaling by RNF43 mutants R-HSA-5340588 7.241865e-01 0.140 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 7.241865e-01 0.140 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 7.241865e-01 0.140 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 7.241865e-01 0.140 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 7.241865e-01 0.140 0 0
Synthesis of PS R-HSA-1483101 7.241865e-01 0.140 0 0
Phosphorylation of Emi1 R-HSA-176417 7.241865e-01 0.140 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 7.241865e-01 0.140 0 0
PDE3B signalling R-HSA-165160 7.241865e-01 0.140 0 0
Threonine catabolism R-HSA-8849175 7.241865e-01 0.140 0 0
PKB-mediated events R-HSA-109703 7.241865e-01 0.140 0 0
Diseases of Base Excision Repair R-HSA-9605308 7.241865e-01 0.140 0 0
Relaxin receptors R-HSA-444821 7.241865e-01 0.140 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 7.241865e-01 0.140 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 7.241865e-01 0.140 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 7.241865e-01 0.140 0 0
Reproduction R-HSA-1474165 7.260092e-01 0.139 0 0
MET activates RAS signaling R-HSA-8851805 7.279861e-01 0.138 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.279861e-01 0.138 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.279861e-01 0.138 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.279861e-01 0.138 0 0
Interleukin-35 Signalling R-HSA-8984722 7.279861e-01 0.138 0 0
Polymerase switching R-HSA-69091 7.279861e-01 0.138 0 0
Leading Strand Synthesis R-HSA-69109 7.279861e-01 0.138 0 0
DNA strand elongation R-HSA-69190 7.305723e-01 0.136 0 0
G0 and Early G1 R-HSA-1538133 7.305723e-01 0.136 0 0
Neutrophil degranulation R-HSA-6798695 7.319383e-01 0.136 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.320615e-01 0.135 0 0
Stimuli-sensing channels R-HSA-2672351 7.326422e-01 0.135 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.338205e-01 0.134 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.340332e-01 0.134 0 0
rRNA processing R-HSA-72312 7.349684e-01 0.134 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.405675e-01 0.130 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.413659e-01 0.130 0 0
Specification of the neural plate border R-HSA-9834899 7.413659e-01 0.130 0 0
Rap1 signalling R-HSA-392517 7.413659e-01 0.130 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.475602e-01 0.126 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.483212e-01 0.126 0 0
RAS processing R-HSA-9648002 7.483212e-01 0.126 0 0
Peroxisomal protein import R-HSA-9033241 7.488695e-01 0.126 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 7.507194e-01 0.125 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.507194e-01 0.125 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.507194e-01 0.125 0 0
Opioid Signalling R-HSA-111885 7.526532e-01 0.123 0 0
Interferon Signaling R-HSA-913531 7.530634e-01 0.123 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.557954e-01 0.122 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.557954e-01 0.122 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.557954e-01 0.122 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.580291e-01 0.120 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.580291e-01 0.120 0 0
Formation of axial mesoderm R-HSA-9796292 7.580291e-01 0.120 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 7.580291e-01 0.120 0 0
Maturation of nucleoprotein R-HSA-9683610 7.580291e-01 0.120 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.590008e-01 0.120 0 0
Cellular response to chemical stress R-HSA-9711123 7.606787e-01 0.119 0 0
Cellular response to starvation R-HSA-9711097 7.607975e-01 0.119 0 0
Metabolism of polyamines R-HSA-351202 7.637047e-01 0.117 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.640439e-01 0.117 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.640439e-01 0.117 0 0
Signaling by TGFBR3 R-HSA-9839373 7.641679e-01 0.117 0 0
G-protein mediated events R-HSA-112040 7.644811e-01 0.117 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.652136e-01 0.116 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.652136e-01 0.116 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 7.652136e-01 0.116 0 0
MET Receptor Activation R-HSA-6806942 7.652136e-01 0.116 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.652136e-01 0.116 0 0
Agmatine biosynthesis R-HSA-351143 7.652136e-01 0.116 0 0
Abacavir transmembrane transport R-HSA-2161517 7.652136e-01 0.116 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.652136e-01 0.116 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.652136e-01 0.116 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 7.652136e-01 0.116 0 0
HDL clearance R-HSA-8964011 7.652136e-01 0.116 0 0
CREB3 factors activate genes R-HSA-8874211 7.652136e-01 0.116 0 0
Nephrin family interactions R-HSA-373753 7.656336e-01 0.116 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.660290e-01 0.116 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.660290e-01 0.116 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.697226e-01 0.114 0 0
SARS-CoV Infections R-HSA-9679506 7.752730e-01 0.111 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.753069e-01 0.111 0 0
Packaging Of Telomere Ends R-HSA-171306 7.763410e-01 0.110 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.763410e-01 0.110 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.763410e-01 0.110 0 0
Influenza Infection R-HSA-168255 7.787198e-01 0.109 0 0
Glucose metabolism R-HSA-70326 7.795673e-01 0.108 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.827950e-01 0.106 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.827950e-01 0.106 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.851555e-01 0.105 0 0
Removal of the Flap Intermediate R-HSA-69166 7.851555e-01 0.105 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.851555e-01 0.105 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.851555e-01 0.105 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.851555e-01 0.105 0 0
Malate-aspartate shuttle R-HSA-9856872 7.851555e-01 0.105 0 0
Physiological factors R-HSA-5578768 7.851555e-01 0.105 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.876007e-01 0.104 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.880134e-01 0.103 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.927197e-01 0.101 0 0
Telomere Extension By Telomerase R-HSA-171319 7.954955e-01 0.099 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.954955e-01 0.099 0 0
Inflammasomes R-HSA-622312 7.954955e-01 0.099 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.960737e-01 0.099 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.986338e-01 0.098 0 0
Translation of Structural Proteins R-HSA-9683701 7.986338e-01 0.098 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 8.001400e-01 0.097 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 8.001400e-01 0.097 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 8.001400e-01 0.097 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 8.001400e-01 0.097 0 0
IFNG signaling activates MAPKs R-HSA-9732724 8.001400e-01 0.097 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 8.001400e-01 0.097 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 8.001400e-01 0.097 0 0
DAG1 core M1 glycosylations R-HSA-8932506 8.001400e-01 0.097 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 8.001400e-01 0.097 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 8.001400e-01 0.097 0 0
FGFR3b ligand binding and activation R-HSA-190371 8.001400e-01 0.097 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 8.001400e-01 0.097 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 8.001400e-01 0.097 0 0
VLDL clearance R-HSA-8964046 8.001400e-01 0.097 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 8.001400e-01 0.097 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 8.001400e-01 0.097 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 8.001400e-01 0.097 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.018753e-01 0.096 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.034082e-01 0.095 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.085886e-01 0.092 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.085886e-01 0.092 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.095681e-01 0.092 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.095681e-01 0.092 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.095681e-01 0.092 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.095681e-01 0.092 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.095681e-01 0.092 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.095681e-01 0.092 0 0
FGFR3 ligand binding and activation R-HSA-190239 8.095681e-01 0.092 0 0
p38MAPK events R-HSA-171007 8.095681e-01 0.092 0 0
Transport and metabolism of PAPS R-HSA-174362 8.095681e-01 0.092 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.101589e-01 0.091 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.133053e-01 0.090 0 0
Platelet calcium homeostasis R-HSA-418360 8.133053e-01 0.090 0 0
Depyrimidination R-HSA-73928 8.135647e-01 0.090 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.135647e-01 0.090 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.139985e-01 0.089 0 0
Chromosome Maintenance R-HSA-73886 8.176470e-01 0.087 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.180913e-01 0.087 0 0
IRS-mediated signalling R-HSA-112399 8.191447e-01 0.087 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.191447e-01 0.087 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.252915e-01 0.083 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.274506e-01 0.082 0 0
Defective pyroptosis R-HSA-9710421 8.276111e-01 0.082 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.298229e-01 0.081 0 0
Interleukin-37 signaling R-HSA-9008059 8.298229e-01 0.081 0 0
DAG1 core M2 glycosylations R-HSA-8932504 8.298724e-01 0.081 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 8.298724e-01 0.081 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 8.298724e-01 0.081 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 8.298724e-01 0.081 0 0
Interleukin-23 signaling R-HSA-9020933 8.298724e-01 0.081 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 8.298724e-01 0.081 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 8.298724e-01 0.081 0 0
Interleukin-9 signaling R-HSA-8985947 8.298724e-01 0.081 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 8.298724e-01 0.081 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 8.298724e-01 0.081 0 0
TGFBR3 PTM regulation R-HSA-9839383 8.298724e-01 0.081 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 8.298724e-01 0.081 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.314739e-01 0.080 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.314739e-01 0.080 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.314739e-01 0.080 0 0
Atorvastatin ADME R-HSA-9754706 8.314739e-01 0.080 0 0
RSV-host interactions R-HSA-9833110 8.336034e-01 0.079 0 0
NCAM1 interactions R-HSA-419037 8.347653e-01 0.078 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.347653e-01 0.078 0 0
Collagen chain trimerization R-HSA-8948216 8.347653e-01 0.078 0 0
MHC class II antigen presentation R-HSA-2132295 8.347992e-01 0.078 0 0
Meiotic recombination R-HSA-912446 8.353017e-01 0.078 0 0
Gap junction trafficking R-HSA-190828 8.407993e-01 0.075 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.446961e-01 0.073 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.446961e-01 0.073 0 0
Formation of the ureteric bud R-HSA-9830674 8.446961e-01 0.073 0 0
Trafficking of AMPA receptors R-HSA-399719 8.451054e-01 0.073 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.451054e-01 0.073 0 0
Neddylation R-HSA-8951664 8.461336e-01 0.073 0 0
Signaling by FGFR in disease R-HSA-1226099 8.476009e-01 0.072 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.510784e-01 0.070 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.510784e-01 0.070 0 0
HCMV Early Events R-HSA-9609690 8.529485e-01 0.069 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.531582e-01 0.069 0 0
Peptide chain elongation R-HSA-156902 8.534314e-01 0.069 0 0
RAB geranylgeranylation R-HSA-8873719 8.538060e-01 0.069 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.541399e-01 0.068 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.551832e-01 0.068 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.551832e-01 0.068 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.551832e-01 0.068 0 0
Enzymatic degradation of Dopamine by monoamine oxidase R-HSA-379398 8.551832e-01 0.068 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.551832e-01 0.068 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 8.551832e-01 0.068 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.551832e-01 0.068 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.551832e-01 0.068 0 0
Gene Silencing by RNA R-HSA-211000 8.589744e-01 0.066 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.592132e-01 0.066 0 0
Potential therapeutics for SARS R-HSA-9679191 8.595022e-01 0.066 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.604248e-01 0.065 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 8.604248e-01 0.065 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.604248e-01 0.065 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.640989e-01 0.063 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.647189e-01 0.063 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.676408e-01 0.062 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.685812e-01 0.061 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.722087e-01 0.059 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.722087e-01 0.059 0 0
Mitochondrial protein import R-HSA-1268020 8.737994e-01 0.059 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.747368e-01 0.058 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.747368e-01 0.058 0 0
Formation of the nephric duct R-HSA-9830364 8.747368e-01 0.058 0 0
Laminin interactions R-HSA-3000157 8.747368e-01 0.058 0 0
Regulation of CDH11 function R-HSA-9762292 8.767295e-01 0.057 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.767295e-01 0.057 0 0
Enzymatic degradation of dopamine by COMT R-HSA-379397 8.767295e-01 0.057 0 0
DNA replication initiation R-HSA-68952 8.767295e-01 0.057 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.767295e-01 0.057 0 0
Metabolism of serotonin R-HSA-380612 8.767295e-01 0.057 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.767295e-01 0.057 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.767295e-01 0.057 0 0
Sperm Motility And Taxes R-HSA-1300642 8.767295e-01 0.057 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.767295e-01 0.057 0 0
Protein localization R-HSA-9609507 8.785543e-01 0.056 0 0
COPII-mediated vesicle transport R-HSA-204005 8.786900e-01 0.056 0 0
G alpha (z) signalling events R-HSA-418597 8.789679e-01 0.056 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.841553e-01 0.053 0 0
Heme degradation R-HSA-189483 8.841553e-01 0.053 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.841553e-01 0.053 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.841738e-01 0.053 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.841738e-01 0.053 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.841738e-01 0.053 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.841738e-01 0.053 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.841738e-01 0.053 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.860564e-01 0.053 0 0
Adaptive Immune System R-HSA-1280218 8.868003e-01 0.052 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.877317e-01 0.052 0 0
PPARA activates gene expression R-HSA-1989781 8.900942e-01 0.051 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.950712e-01 0.048 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.950712e-01 0.048 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.950712e-01 0.048 0 0
vRNP Assembly R-HSA-192905 8.950712e-01 0.048 0 0
Conjugation of benzoate with glycine R-HSA-177135 8.950712e-01 0.048 0 0
vRNA Synthesis R-HSA-192814 8.950712e-01 0.048 0 0
Bicarbonate transporters R-HSA-425381 8.950712e-01 0.048 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.950712e-01 0.048 0 0
LGI-ADAM interactions R-HSA-5682910 8.950712e-01 0.048 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.950712e-01 0.048 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.950712e-01 0.048 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.951163e-01 0.048 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.951163e-01 0.048 0 0
Integration of energy metabolism R-HSA-163685 8.966766e-01 0.047 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.980370e-01 0.047 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.980370e-01 0.047 0 0
Diseases of hemostasis R-HSA-9671793 8.980370e-01 0.047 0 0
Maturation of nucleoprotein R-HSA-9694631 8.980370e-01 0.047 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.995069e-01 0.046 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.995069e-01 0.046 0 0
Cristae formation R-HSA-8949613 8.995069e-01 0.046 0 0
Insulin processing R-HSA-264876 8.995069e-01 0.046 0 0
Ca2+ pathway R-HSA-4086398 9.025418e-01 0.045 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.051547e-01 0.043 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.051547e-01 0.043 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 9.051547e-01 0.043 0 0
Pyrimidine salvage R-HSA-73614 9.101563e-01 0.041 0 0
Developmental Biology R-HSA-1266738 9.102269e-01 0.041 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 9.103401e-01 0.041 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 9.103401e-01 0.041 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 9.103401e-01 0.041 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 9.103401e-01 0.041 0 0
Signaling by NODAL R-HSA-1181150 9.103401e-01 0.041 0 0
Creatine metabolism R-HSA-71288 9.103401e-01 0.041 0 0
Pregnenolone biosynthesis R-HSA-196108 9.103401e-01 0.041 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 9.103401e-01 0.041 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 9.106847e-01 0.041 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 9.106847e-01 0.041 0 0
Plasmalogen biosynthesis R-HSA-75896 9.106847e-01 0.041 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 9.106847e-01 0.041 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 9.106847e-01 0.041 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 9.106847e-01 0.041 0 0
Anchoring fibril formation R-HSA-2214320 9.106847e-01 0.041 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 9.106847e-01 0.041 0 0
Sodium/Calcium exchangers R-HSA-425561 9.106847e-01 0.041 0 0
DS-GAG biosynthesis R-HSA-2022923 9.106847e-01 0.041 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.133702e-01 0.039 0 0
PI Metabolism R-HSA-1483255 9.158139e-01 0.038 0 0
Iron uptake and transport R-HSA-917937 9.161495e-01 0.038 0 0
Eukaryotic Translation Termination R-HSA-72764 9.182109e-01 0.037 0 0
mRNA Capping R-HSA-72086 9.197705e-01 0.036 0 0
Glucagon-type ligand receptors R-HSA-420092 9.197705e-01 0.036 0 0
G-protein activation R-HSA-202040 9.212404e-01 0.036 0 0
Lagging Strand Synthesis R-HSA-69186 9.212404e-01 0.036 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.212404e-01 0.036 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.227079e-01 0.035 0 0
Cleavage of the damaged purine R-HSA-110331 9.227079e-01 0.035 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 9.239756e-01 0.034 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 9.239756e-01 0.034 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 9.239756e-01 0.034 0 0
GRB2 events in EGFR signaling R-HSA-179812 9.239756e-01 0.034 0 0
Conjugation of salicylate with glycine R-HSA-177128 9.239756e-01 0.034 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.239756e-01 0.034 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 9.239756e-01 0.034 0 0
OAS antiviral response R-HSA-8983711 9.239756e-01 0.034 0 0
Collagen degradation R-HSA-1442490 9.260861e-01 0.033 0 0
Translation of Structural Proteins R-HSA-9694635 9.281028e-01 0.032 0 0
Neurotransmitter clearance R-HSA-112311 9.284354e-01 0.032 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.284354e-01 0.032 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.303404e-01 0.031 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 9.303404e-01 0.031 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.303404e-01 0.031 0 0
Depurination R-HSA-73927 9.303404e-01 0.031 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.308829e-01 0.031 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.308829e-01 0.031 0 0
Attachment and Entry R-HSA-9694614 9.308829e-01 0.031 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.325107e-01 0.030 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 9.352894e-01 0.029 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.352894e-01 0.029 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 9.352894e-01 0.029 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 9.352894e-01 0.029 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.352894e-01 0.029 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 9.352894e-01 0.029 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.352894e-01 0.029 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.352894e-01 0.029 0 0
Signaling by Insulin receptor R-HSA-74752 9.363814e-01 0.029 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.372848e-01 0.028 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.377896e-01 0.028 0 0
FGFR2 alternative splicing R-HSA-6803529 9.394004e-01 0.027 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.394004e-01 0.027 0 0
Ethanol oxidation R-HSA-71384 9.394004e-01 0.027 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.394004e-01 0.027 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.394004e-01 0.027 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.432374e-01 0.025 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 9.449200e-01 0.025 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.449200e-01 0.025 0 0
CRMPs in Sema3A signaling R-HSA-399956 9.449200e-01 0.025 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.449200e-01 0.025 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.449200e-01 0.025 0 0
Prolactin receptor signaling R-HSA-1170546 9.449200e-01 0.025 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.449200e-01 0.025 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.449200e-01 0.025 0 0
Ciprofloxacin ADME R-HSA-9793528 9.449200e-01 0.025 0 0
HDL assembly R-HSA-8963896 9.449200e-01 0.025 0 0
Zinc transporters R-HSA-435354 9.449200e-01 0.025 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.449200e-01 0.025 0 0
Intraflagellar transport R-HSA-5620924 9.457978e-01 0.024 0 0
Gluconeogenesis R-HSA-70263 9.457978e-01 0.024 0 0
Selenocysteine synthesis R-HSA-2408557 9.463870e-01 0.024 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.469142e-01 0.024 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.469142e-01 0.024 0 0
Carnitine shuttle R-HSA-200425 9.469142e-01 0.024 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.493177e-01 0.023 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.495222e-01 0.022 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.529064e-01 0.021 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.531178e-01 0.021 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.531178e-01 0.021 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.531178e-01 0.021 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.531178e-01 0.021 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.531178e-01 0.021 0 0
Signaling by Activin R-HSA-1502540 9.531178e-01 0.021 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 9.531178e-01 0.021 0 0
Protein lipoylation R-HSA-9857492 9.531178e-01 0.021 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.531178e-01 0.021 0 0
Protein repair R-HSA-5676934 9.531178e-01 0.021 0 0
DNA Damage Reversal R-HSA-73942 9.531178e-01 0.021 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.534408e-01 0.021 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.535343e-01 0.021 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.535343e-01 0.021 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.535343e-01 0.021 0 0
Viral mRNA Translation R-HSA-192823 9.536840e-01 0.021 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.551530e-01 0.020 0 0
Base Excision Repair R-HSA-73884 9.557729e-01 0.020 0 0
Extension of Telomeres R-HSA-180786 9.576609e-01 0.019 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.576609e-01 0.019 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.591964e-01 0.018 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.593603e-01 0.018 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.593603e-01 0.018 0 0
Telomere Maintenance R-HSA-157579 9.595246e-01 0.018 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.600959e-01 0.018 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.600959e-01 0.018 0 0
Activation of SMO R-HSA-5635838 9.600959e-01 0.018 0 0
Fructose catabolism R-HSA-70350 9.600959e-01 0.018 0 0
Differentiation of T cells R-HSA-9945266 9.600959e-01 0.018 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.600959e-01 0.018 0 0
Attachment and Entry R-HSA-9678110 9.600959e-01 0.018 0 0
Gap junction assembly R-HSA-190861 9.601915e-01 0.018 0 0
eNOS activation R-HSA-203615 9.601915e-01 0.018 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.601915e-01 0.018 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.608171e-01 0.017 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.609540e-01 0.017 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.615308e-01 0.017 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.625533e-01 0.017 0 0
Parasitic Infection Pathways R-HSA-9824443 9.630228e-01 0.016 0 0
Leishmania infection R-HSA-9658195 9.630228e-01 0.016 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.638123e-01 0.016 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.644818e-01 0.016 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.646944e-01 0.016 0 0
Aquaporin-mediated transport R-HSA-445717 9.650757e-01 0.015 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 9.660357e-01 0.015 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.660357e-01 0.015 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.660357e-01 0.015 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.660357e-01 0.015 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.660357e-01 0.015 0 0
Phase 2 - plateau phase R-HSA-5576893 9.660357e-01 0.015 0 0
Passive transport by Aquaporins R-HSA-432047 9.660357e-01 0.015 0 0
Fibronectin matrix formation R-HSA-1566977 9.660357e-01 0.015 0 0
Synthesis of PG R-HSA-1483148 9.660357e-01 0.015 0 0
Coenzyme A biosynthesis R-HSA-196783 9.660357e-01 0.015 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.660357e-01 0.015 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.660357e-01 0.015 0 0
Amine ligand-binding receptors R-HSA-375280 9.672657e-01 0.014 0 0
Surfactant metabolism R-HSA-5683826 9.672657e-01 0.014 0 0
Platelet degranulation R-HSA-114608 9.674795e-01 0.014 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.689795e-01 0.014 0 0
ECM proteoglycans R-HSA-3000178 9.697581e-01 0.013 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.707174e-01 0.013 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.710916e-01 0.013 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.710916e-01 0.013 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.710916e-01 0.013 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.710916e-01 0.013 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 9.710916e-01 0.013 0 0
Catecholamine biosynthesis R-HSA-209905 9.710916e-01 0.013 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.710916e-01 0.013 0 0
HCMV Infection R-HSA-9609646 9.711060e-01 0.013 0 0
HCMV Late Events R-HSA-9610379 9.726079e-01 0.012 0 0
Insulin receptor recycling R-HSA-77387 9.729255e-01 0.012 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.738262e-01 0.012 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.738262e-01 0.012 0 0
Ion transport by P-type ATPases R-HSA-936837 9.739916e-01 0.011 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.753952e-01 0.011 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.753952e-01 0.011 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.753952e-01 0.011 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.753952e-01 0.011 0 0
Ion homeostasis R-HSA-5578775 9.761616e-01 0.010 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.763844e-01 0.010 0 0
Synthesis of PC R-HSA-1483191 9.766233e-01 0.010 0 0
Neurotransmitter release cycle R-HSA-112310 9.775274e-01 0.010 0 0
Developmental Cell Lineages R-HSA-9734767 9.788364e-01 0.009 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.790583e-01 0.009 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.790583e-01 0.009 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.790583e-01 0.009 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.790583e-01 0.009 0 0
Pyrimidine biosynthesis R-HSA-500753 9.790583e-01 0.009 0 0
Conjugation of carboxylic acids R-HSA-159424 9.790583e-01 0.009 0 0
Amino Acid conjugation R-HSA-156587 9.790583e-01 0.009 0 0
Transport of nucleotide sugars R-HSA-727802 9.790583e-01 0.009 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.790583e-01 0.009 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.794138e-01 0.009 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.794138e-01 0.009 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.807409e-01 0.008 0 0
Cargo concentration in the ER R-HSA-5694530 9.820648e-01 0.008 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.820648e-01 0.008 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.821762e-01 0.008 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.821762e-01 0.008 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.821762e-01 0.008 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.821762e-01 0.008 0 0
Protein hydroxylation R-HSA-9629569 9.821762e-01 0.008 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.827916e-01 0.008 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.827916e-01 0.008 0 0
Maturation of spike protein R-HSA-9694548 9.830977e-01 0.007 0 0
tRNA Aminoacylation R-HSA-379724 9.844852e-01 0.007 0 0
Interleukin-10 signaling R-HSA-6783783 9.845415e-01 0.007 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.848301e-01 0.007 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.848301e-01 0.007 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.848301e-01 0.007 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.848301e-01 0.007 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.848301e-01 0.007 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.850873e-01 0.007 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.850873e-01 0.007 0 0
Heme biosynthesis R-HSA-189451 9.850873e-01 0.007 0 0
Mitochondrial protein degradation R-HSA-9837999 9.856416e-01 0.006 0 0
Ion channel transport R-HSA-983712 9.860708e-01 0.006 0 0
Viral Infection Pathways R-HSA-9824446 9.861841e-01 0.006 0 0
Recycling of bile acids and salts R-HSA-159418 9.864085e-01 0.006 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.866731e-01 0.006 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.868512e-01 0.006 0 0
Transmission across Chemical Synapses R-HSA-112315 9.870429e-01 0.006 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.870889e-01 0.006 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.870889e-01 0.006 0 0
Metabolism of porphyrins R-HSA-189445 9.872549e-01 0.006 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.881773e-01 0.005 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.881773e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.881773e-01 0.005 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.881773e-01 0.005 0 0
Neuronal System R-HSA-112316 9.886121e-01 0.005 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.890115e-01 0.005 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.890115e-01 0.005 0 0
Fructose metabolism R-HSA-5652084 9.890115e-01 0.005 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.890115e-01 0.005 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 9.890115e-01 0.005 0 0
Cellular hexose transport R-HSA-189200 9.890115e-01 0.005 0 0
LDL clearance R-HSA-8964038 9.890115e-01 0.005 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.890115e-01 0.005 0 0
tRNA processing R-HSA-72306 9.896113e-01 0.005 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.896670e-01 0.005 0 0
Signal amplification R-HSA-392518 9.897208e-01 0.004 0 0
RA biosynthesis pathway R-HSA-5365859 9.897208e-01 0.004 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.897208e-01 0.004 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.904779e-01 0.004 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.906479e-01 0.004 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.906479e-01 0.004 0 0
Regulation of insulin secretion R-HSA-422356 9.909634e-01 0.004 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.910195e-01 0.004 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.910669e-01 0.004 0 0
Platelet homeostasis R-HSA-418346 9.912953e-01 0.004 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.913995e-01 0.004 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.916432e-01 0.004 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.916855e-01 0.004 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.920407e-01 0.003 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.920407e-01 0.003 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.920407e-01 0.003 0 0
Complex III assembly R-HSA-9865881 9.920407e-01 0.003 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.920407e-01 0.003 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.920407e-01 0.003 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.921004e-01 0.003 0 0
Triglyceride catabolism R-HSA-163560 9.922401e-01 0.003 0 0
Kidney development R-HSA-9830369 9.928690e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.930440e-01 0.003 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.930550e-01 0.003 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.930906e-01 0.003 0 0
G protein gated Potassium channels R-HSA-1296059 9.932262e-01 0.003 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.932262e-01 0.003 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.932262e-01 0.003 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.932262e-01 0.003 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.932262e-01 0.003 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.932262e-01 0.003 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.932262e-01 0.003 0 0
Hyaluronan degradation R-HSA-2160916 9.932262e-01 0.003 0 0
Fertilization R-HSA-1187000 9.932262e-01 0.003 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.932262e-01 0.003 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.932575e-01 0.003 0 0
Voltage gated Potassium channels R-HSA-1296072 9.932621e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.932621e-01 0.003 0 0
Translation R-HSA-72766 9.933581e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.936340e-01 0.003 0 0
Elastic fibre formation R-HSA-1566948 9.941519e-01 0.003 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.941519e-01 0.003 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 9.942351e-01 0.003 0 0
Urea cycle R-HSA-70635 9.942351e-01 0.003 0 0
Abacavir ADME R-HSA-2161522 9.942351e-01 0.003 0 0
Sphingolipid catabolism R-HSA-9845614 9.942351e-01 0.003 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.942351e-01 0.003 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.942351e-01 0.003 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.942902e-01 0.002 0 0
Selenoamino acid metabolism R-HSA-2408522 9.947220e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.949262e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.949352e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.949428e-01 0.002 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.950938e-01 0.002 0 0
Signaling by BMP R-HSA-201451 9.950938e-01 0.002 0 0
Triglyceride biosynthesis R-HSA-75109 9.950938e-01 0.002 0 0
Synthesis of PE R-HSA-1483213 9.950938e-01 0.002 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.950938e-01 0.002 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.950938e-01 0.002 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.950938e-01 0.002 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.952953e-01 0.002 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.952953e-01 0.002 0 0
Diseases of Immune System R-HSA-5260271 9.955996e-01 0.002 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.955996e-01 0.002 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.958246e-01 0.002 0 0
Phosphate bond hydrolysis by NTPDase proteins R-HSA-8850843 9.958246e-01 0.002 0 0
The phototransduction cascade R-HSA-2514856 9.958721e-01 0.002 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.963277e-01 0.002 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.964466e-01 0.002 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.964466e-01 0.002 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.964466e-01 0.002 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.968267e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.969045e-01 0.001 0 0
Activation of GABAB receptors R-HSA-991365 9.971356e-01 0.001 0 0
GABA B receptor activation R-HSA-977444 9.971356e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.971356e-01 0.001 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.974266e-01 0.001 0 0
Pyrimidine catabolism R-HSA-73621 9.975192e-01 0.001 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.975192e-01 0.001 0 0
DAG1 glycosylations R-HSA-8931838 9.978100e-01 0.001 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.978100e-01 0.001 0 0
HS-GAG degradation R-HSA-2024096 9.978100e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.978521e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.978680e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.980075e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.980124e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.981344e-01 0.001 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.981363e-01 0.001 0 0
Hemostasis R-HSA-109582 9.981648e-01 0.001 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.984140e-01 0.001 0 0
Triglyceride metabolism R-HSA-8979227 9.985730e-01 0.001 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.986504e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.986504e-01 0.001 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.986504e-01 0.001 0 0
Metal ion SLC transporters R-HSA-425410 9.987966e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.988377e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.989102e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.990100e-01 0.000 0 0
HS-GAG biosynthesis R-HSA-2022928 9.990227e-01 0.000 0 0
Glycosphingolipid transport R-HSA-9845576 9.990227e-01 0.000 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.990227e-01 0.000 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.990227e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.990602e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.992079e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.992229e-01 0.000 0 0
Pentose phosphate pathway R-HSA-71336 9.993978e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.994478e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.994745e-01 0.000 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.994876e-01 0.000 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.994876e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.994935e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.995186e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.995384e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.995640e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.995677e-01 0.000 0 0
Interferon gamma signaling R-HSA-877300 9.996014e-01 0.000 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.996269e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.996290e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.996780e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.997224e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997583e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.997714e-01 0.000 0 0
Methylation R-HSA-156581 9.997714e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.997896e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.997933e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998371e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998501e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.998676e-01 0.000 0 0
Immune System R-HSA-168256 9.998716e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.998802e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.998981e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.998981e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999049e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.999133e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.999262e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.999262e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999270e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999444e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.999466e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999527e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999596e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999599e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999599e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.999613e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999630e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999639e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.999655e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999671e-01 0.000 0 0
Digestion R-HSA-8935690 9.999671e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999674e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999674e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999704e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999744e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999744e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999797e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999853e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999860e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999894e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999907e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999910e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999911e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999937e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999944e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999945e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999947e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999964e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999985e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999989e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999989e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999994e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999994e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999995e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999995e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999996e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999996e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999997e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999998e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999998e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 1.000000e+00 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 1.000000e+00 0.000 0 0
G alpha (q) signalling events R-HSA-416476 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways