DAPK1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Y Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Log-Odds: Y Sites / Y Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A4FU28	S138	Sugiyama	CTAGE9	EKAAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKS
A5A3E0	Y940	Sugiyama	POTEF A26C1B	ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
A6NHL2	Y319	Sugiyama	TUBAL3	TTACFESSNQLVKCDPRLGKyMACCLLyRGDVVPKEVNAAI
A6NMY6	Y333	Sugiyama	ANXA2P2 ANX2L2 ANX2P2 LPC2B	KsLyyyIQQDTKGDyQKALLyLCGGDD______________
O14950	S20	EPSD\|PSP	MYL12B MRLC2 MYLC2B	_MSSKKAKTKTTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
O14974	S695	Sugiyama	PPP1R12A MBS MYPT1	DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974	T696	Sugiyama	PPP1R12A MBS MYPT1	EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O15067	S215	Sugiyama	PFAS KIAA0361	LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15078	S1159	Sugiyama	CEP290 BBS14 KIAA0373 NPHP6	LELEKNEMELKVEVSKLREIsDIARRQVEILNAQQQSRDKE
O43293	S309	GPS6\|EPSD	DAPK3 ZIPK	GRKPERRRLKtTRLKEYtIKsHssLPPNNsYADFERFsKVL
O43293	S311	GPS6\|EPSD	DAPK3 ZIPK	KPERRRLKtTRLKEYtIKsHssLPPNNsYADFERFsKVLEE
O43293	S312	GPS6\|EPSD	DAPK3 ZIPK	PERRRLKtTRLKEYtIKsHssLPPNNsYADFERFsKVLEEA
O43293	S318	GPS6\|EPSD	DAPK3 ZIPK	KtTRLKEYtIKsHssLPPNNsYADFERFsKVLEEAAAAEEG
O43293	S326	GPS6\|EPSD	DAPK3 ZIPK	tIKsHssLPPNNsYADFERFsKVLEEAAAAEEGLRELQRSR
O43293	T299	GPS6\|EPSD	DAPK3 ZIPK	RRRNVRGEDSGRKPERRRLKtTRLKEYtIKsHssLPPNNsY
O43707	T69	Sugiyama	ACTN4	EKQQRKTFTAWCNsHLRKAGtQIENIDEDFRDGLKLMLLLE
O43847	S96	Sugiyama	NRDC NRD1	SRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYRYI
O60361	Y136	Sugiyama	NME2P1	SLRFKPEELVDYKSCAHDWVyE___________________
O60814	S37	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814	Y38	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75643	S17	Sugiyama	SNRNP200 ASCC3L1 BRR2 HELIC2 KIAA0788	____MADVTARsLQYEYKANsNLVLQADRsLIDRTRRDEPT
O75665	S899	Sugiyama	OFD1 CXorf5	EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O75821	T244	Sugiyama	EIF3G EIF3S4	RRGESMQPNRRADDNAtIRVtNLSEDTRETDLQELFRPFGs
O76021	S314	Sugiyama	RSL1D1 CATX11 CSIG PBK1 L12	RNFEKQKERKKKRQQARKtAsVLsKDDVAPEsGDtTVKKPE
O95786	S654	EPSD\|PSP	RIGI DDX58	VKTRALVDALKNWIEGNPKLsFLKPGILTGRGKtNQNtGMt
O95786	S764	EPSD\|PSP	RIGI DDX58	NAGVIEKEQINMYKEKMMNDsILRLQtWDEAVFREKILHIQ
O95786	S8	EPSD\|PSP	RIGI DDX58	_____________MTTEQRRsLQAFQDYIRKTLDPTYILSY
O95786	T667	SIGNOR\|EPSD\|PSP	RIGI DDX58	IEGNPKLsFLKPGILTGRGKtNQNtGMtLPAQKCILDAFKA
O95786	T671	EPSD\|PSP	RIGI DDX58	PKLsFLKPGILTGRGKtNQNtGMtLPAQKCILDAFKASGDH
O95786	T674	EPSD\|PSP	RIGI DDX58	sFLKPGILTGRGKtNQNtGMtLPAQKCILDAFKASGDHNIL
O95786	T770	EPSD\|PSP	RIGI DDX58	KEQINMYKEKMMNDsILRLQtWDEAVFREKILHIQTHEKFI
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00338	Y239	Sugiyama	LDHA PIG19	GtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVADL
P00491	S163	Sugiyama	PNP NP	GQNPLRGPNDERFGDRFPAMsDAyDRtMRQRALstWKQMGE
P00558	T168	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P02545	S282	Sugiyama	LMNA LMN1	ELEKTYSAKLDNARQsAERNsNLVGAAHEELQQsRIRIDsL
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04406	Y320	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE_____
P04637	S20	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TP53 P53	_MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQAM
P04637	S269	EPSD\|PSP	TP53 P53	RPILTIITLEDSSGNLLGRNsFEVRVCACPGRDRRtEEENL
P04637	T18	SIGNOR\|EPSD\|PSP	TP53 P53	___MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQ
P04792	S78	Sugiyama	HSPB1 HSP27 HSP28	LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792	S83	Sugiyama	HSPB1 HSP27 HSP28	IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P05362	Y455	Sugiyama	ICAM1	GtFPLPIGEsVtVtRDLEGtyLCRARSTQGEVTRKVTVNVL
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733	Y270	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P06899	S37	Sugiyama	H2BC11 H2BFR HIST1H2BJ	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P06899	Y38	Sugiyama	H2BC11 H2BFR HIST1H2BJ	AVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSK
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S320	Sugiyama	LDHB	GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195	T302	Sugiyama	LDHB	YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205	T168	Sugiyama	PGK2 PGKB	EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07237	Y94	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07355	Y333	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	KsLyyyIQQDTKGDyQKALLyLCGGDD______________
P07737	T65	Sugiyama	PFN1	PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737	Y60	Sugiyama	PFN1	FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S53	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900	S623	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	tyGWTANMERIMKAQALRDNstMGyMAAKKHLEINPDHsII
P07900	T317	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P07900	T88	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	sKLDsGKELHINLIPNKQDRtLtIVDtGIGMTKADLINNLG
P07900	T90	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LDsGKELHINLIPNKQDRtLtIVDtGIGMTKADLINNLGtI
P07900	Y284	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P07900	Y309	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900	Y492	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DEMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLR
P08238	S452	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	T309	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238	T467	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238	Y276	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08758	S136	Sugiyama	ANXA5 ANX5 ENX2 PP4	sRtPEELRAIKQVyEEEyGssLEDDVVGDTSGYYQRMLVVL
P08758	T10	Sugiyama	ANXA5 ANX5 ENX2 PP4	___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P08758	T111	Sugiyama	ANXA5 ANX5 ENX2 PP4	yDAyELKHALKGAGTNEKVLtEIIAsRtPEELRAIKQVyEE
P09493	S283	GPS6\|SIGNOR\|EPSD\|PSP	TPM1 C15orf13 TMSA	QKLKYKAISEELDHALNDMtsI___________________
P09651	S360	Sugiyama	HNRNPA1 HNRPA1	PyGGGGQyFAKPRNQGGyGGssssssyGsGRRF________
P09651	S368	Sugiyama	HNRNPA1 HNRPA1	FAKPRNQGGyGGssssssyGsGRRF________________
P09972	S45	Sugiyama	ALDOC ALDC	APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P0CG41	S138	Sugiyama	CTAGE8	EKAAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKS
P0CG47	S57	Sugiyama	UBB	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48	S57	Sugiyama	UBC	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P10809	T422	Sugiyama	HSPD1 HSP60	AVLKVGGtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGC
P10809	Y223	Sugiyama	HSPD1 HSP60	DGKtLNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAy
P10809	Y227	Sugiyama	HSPD1 HSP60	LNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLs
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T47	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtNtV
P11142	T64	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11142	Y41	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11388	S1377	Sugiyama	TOP2A TOP2	KtKTsPKLsNKELKPQKsVVsDLEADDVKGsVPLsssPPAt
P12277	S163	Sugiyama	CKB CKBB	PPHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAE
P12277	T322	Sugiyama	CKB CKBB	LGKHEKFsEVLKRLRLQKRGtGGVDtAAVGGVFDVsNADRL
P12277	T327	Sugiyama	CKB CKBB	KFsEVLKRLRLQKRGtGGVDtAAVGGVFDVsNADRLGFSEV
P13639	Y671	Sugiyama	EEF2 EF2	CFGPDGTGPNILTDITKGVQyLNEIKDSVVAGFQWATKEGA
P13667	T380	Sugiyama	PDIA4 ERP70 ERP72	PEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGHR
P13674	Y282	Sugiyama	P4HA1 P4HA	ASDDQSDQKTTPKKKGVAVDyLPERQKyEMLCRGEGIKMTP
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618	T45	Sugiyama	PKM OIP3 PK2 PK3 PKM2	TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14625	S515	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14625	T519	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy
P14866	S544	Sugiyama	HNRNPL HNRPL P/OKcl.14	LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P15880	S249	Sugiyama	RPS2 RPS4	CtAtLGNFAKATFDAISKTysyLtPDLWKEtVFtKsPyQEF
P15880	T202	Sugiyama	RPS2 RPS4	CKVTGRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDC
P15880	Y250	Sugiyama	RPS2 RPS4	tAtLGNFAKATFDAISKTysyLtPDLWKEtVFtKsPyQEFt
P17066	T228	Sugiyama	HSPA6 HSP70B'	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17066	T49	Sugiyama	HSPA6 HSP70B'	EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P17066	Y43	Sugiyama	HSPA6 HSP70B'	FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P19105	S19	SIGNOR	MYL12A MLCB MRLC3 RLC	__MSSKRTKTKTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P19105	T18	SIGNOR	MYL12A MLCB MRLC3 RLC	___MSSKRTKTKTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
P19338	S328	Sugiyama	NCL	NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20618	S157	Sugiyama	PSMB1 PSC5	IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P20618	S162	Sugiyama	PSMB1 PSC5	DEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLDNQVG
P20618	Y158	Sugiyama	PSMB1 PSC5	IGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLD
P22059	S240	Sugiyama	OSBP OSBP1	DLSTCNDLIAKHGTALQRsLsELEsLKLPAESNEKIKQVNE
P22392	Y151	Sugiyama	NME2 NM23B	SLWFKPEELVDyKSCAHDWVyE___________________
P23527	S37	Sugiyama	H2BC17 H2BFH H2BFN HIST1H2BO	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P23527	Y38	Sugiyama	H2BC17 H2BFH H2BFN HIST1H2BO	AVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSK
P24844	S20	GPS6\|PSP	MYL9 MLC2 MRLC1 MYRL2	_MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P25205	S160	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MCM3	KVVRSVHYCPATKKTIERRysDLttLVAFPSSSVYPTKDEE
P25398	Y127	Sugiyama	RPS12	sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P25789	T10	Sugiyama	PSMA4 HC9 PSC9	___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P25789	Y5	Sugiyama	PSMA4 HC9 PSC9	________________MSRRyDsRttIFsPEGRLYQVEYAM
P26038	T526	Sugiyama	MSN	EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26641	T287	Sugiyama	EEF1G EF1G PRO1608	EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348	S63	Sugiyama	YWHAQ	LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR
P27708	S1859	Sugiyama	CAD	RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P28066	S174	Sugiyama	PSMA5	FHMDPsGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEA
P28066	S179	Sugiyama	PSMA5	sGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEAIKSSL
P29401	S332	Sugiyama	TKT	GDKIATRKAYGQALAKLGHAsDRIIALDGDtKNstFsEIFK
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30086	S52	Sugiyama	PEBP1 PBP PEBP	AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P31153	Y235	Sugiyama	MAT2A AMS2 MATA2	LDEMRDALKEKVIKAVVPAKyLDEDtIyHLQPsGRFVIGGP
P31327	T45	Sugiyama	CPS1	AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P31946	S65	Sugiyama	YWHAB	LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR
P31948	Y354	Sugiyama	STIP1	DVLKKCQQAEKILKEQERLAyINPDLALEEKNKGNECFQKG
P32119	S112	Sugiyama	PRDX2 NKEFB TDPX1	KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P32119	Y115	Sugiyama	PRDX2 NKEFB TDPX1	GLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFIIDGK
P33778	S37	Sugiyama	H2BC3 H2BFF HIST1H2BB	KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P33778	Y38	Sugiyama	H2BC3 H2BFF HIST1H2BB	AITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSK
P34931	T228	Sugiyama	HSPA1L	DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931	T49	Sugiyama	HSPA1L	EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQNTV
P34931	Y43	Sugiyama	HSPA1L	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P34932	S76	Sugiyama	HSPA4 APG2 HSPH2	VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35579	T1745	Sugiyama	MYH9	RRLEARIAQLEEELEEEQGNtELINDRLKKANLQIDQINtD
P35606	S350	Sugiyama	COPB2	MGDAEIKDGERLPLAVKDMGsCEIyPQtIQHNPNGRFVVVC
P36578	S55	Sugiyama	RPL4 RPL1	DIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVAR
P36578	S66	Sugiyama	RPL4 RPL1	KNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHR
P36578	T62	Sugiyama	RPL4 RPL1	TNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGG
P36578	T69	Sugiyama	RPL4 RPL1	RQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHRsGQ
P36578	Y52	Sugiyama	RPL4 RPL1	IRPDIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRA
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37837	S13	Sugiyama	TALDO1 TAL TALDO TALDOR	________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P37840	S129	GPS6	SNCA NACP PARK1	QEGILEDMPVDPDNEAyEMPsEEGyQDyEPEA_________
P38646	S212	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	tVPAyFNDsQRQAtKDAGQIsGLNVLRVINEPTAAALAyGL
P38646	T111	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VAFtADGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDP
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40261	Y11	Sugiyama	NNMT	__________MESGFTSKDTyLSHFNPRDYLEKYYKFGSRH
P40429	S77	EPSD\|PSP	RPL13A	FLRKRMNtNPSRGPyHFRAPsRIFWRTVRGMLPHKTKRGQA
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P40925	S153	Sugiyama	MDH1 MDHA	ANtNCLtAsKSAPSIPKENFsCLtRLDHNRAKAQIALKLGV
P40926	Y80	Sugiyama	MDH2	HtPGVAADLsHIEtKAAVKGyLGPEQLPDCLKGCDVVVIPA
P42677	T74	Sugiyama	RPS27 MPS1	VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P43243	T150	Sugiyama	MATR3 KIAA0723	EDKItPENLPQILLQLKRRRtEEGPtLsyGRDGRsAtREPP
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P48741	T228	Sugiyama	HSPA7 HSP70B	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P48741	T49	Sugiyama	HSPA7 HSP70B	EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P48741	Y43	Sugiyama	HSPA7 HSP70B	FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49589	T24	Sugiyama	CARS1 CARS	SSGQQGKGRRVQPQWsPPAGtQPCRLHLyNsLtRNKEVFIP
P50990	S23	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	LHVPKAPGFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTT
P50990	T381	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	VVFKHEKEDGAIstIVLRGstDNLMDDIERAVDDGVNtFKV
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P53355	S289	PSP	DAPK1 DAPK	SLQHPWIKPKDTQQALSRKAsAVNMEKFKKFAARKKWKQsV
P53355	S308	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	DAPK1 DAPK	AsAVNMEKFKKFAARKKWKQsVRLIsLCQRLsRsFLsRsNM
P53355	S313	GPS6	DAPK1 DAPK	MEKFKKFAARKKWKQsVRLIsLCQRLsRsFLsRsNMSVARs
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999	S118	Sugiyama	SUB1 PC4 RPO2TC1	PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999	S12	Sugiyama	SUB1 PC4 RPO2TC1	_________MPKSKELVsssssGsDsDsEVDKKLKRKKQVA
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652	T48	Sugiyama	HSPA2	EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTNTI
P54652	Y42	Sugiyama	HSPA2	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55060	Y369	Sugiyama	CSE1L CAS XPO2	VPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAACDL
P55209	T64	Sugiyama	NAP1L1 NRP	QNPQILAALQERLDGLVEtPtGyIEsLPRVVKRRVNALKNL
P55209	Y66	Sugiyama	NAP1L1 NRP	PQILAALQERLDGLVEtPtGyIEsLPRVVKRRVNALKNLQV
P57053	S37	Sugiyama	H2BC12L H2BFS H2BS1	KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053	Y38	Sugiyama	H2BC12L H2BFS H2BS1	AVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssK
P58876	S37	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876	Y38	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
P60174	T214	Sugiyama	TPI1 TPI	KsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGG
P60174	T38	Sugiyama	TPI1 TPI	RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	T304	Sugiyama	ACTB	KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P60709	Y240	Sugiyama	ACTB	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60842	Y70	Sugiyama	EIF4A1 DDX2A EIF4A	yGFEKPsAIQQRAILPCIKGyDVIAQAQsGtGKTATFAISI
P60900	Y159	Sugiyama	PSMA6 PROS27	ILIGIDEEQGPQVYKCDPAGyyCGFKATAAGVKQtEstsFL
P61158	S232	Sugiyama	ACTR3 ARP3	EVGIPPEQSLETAKAVKERysyVCPDLVKEFNKYDTDGSKW
P61158	Y233	Sugiyama	ACTR3 ARP3	VGIPPEQSLETAKAVKERysyVCPDLVKEFNKYDTDGSKWI
P61247	Y256	Sugiyama	RPS3A FTE1 MFTL	sssGKAtGDEtGAKVERADGyEPPVQEsV____________
P61247	Y31	Sugiyama	RPS3A FTE1 MFTL	KGGKKGAKKKVVDPFSKKDWyDVKAPAMFNIRNIGKTLVTR
P61313	Y6	Sugiyama	RPL15 EC45 TCBAP0781	_______________MGAYKyIQELWRKKQSDVMRFLLRVR
P61916	T44	Sugiyama	NPC2 HE1	FKDCGsVDGVIKEVNVsPCPtQPCQLSKGQSYSVNVTFTSN
P61978	S36	Sugiyama	HNRNPK HNRPK	NGEFGKRPAEDMEEEQAFKRsRNtDEMVELRILLQSKNAGA
P61978	T39	Sugiyama	HNRNPK HNRPK	FGKRPAEDMEEEQAFKRsRNtDEMVELRILLQSKNAGAVIG
P61981	S64	Sugiyama	YWHAG	LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA
P61981	T31	Sugiyama	YWHAG	ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62269	Y95	Sugiyama	RPS18 D6S218E	RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	Y55	Sugiyama	RPS11	RYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILsG
P62424	T84	Sugiyama	RPL7A SURF-3 SURF3	QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62424	T93	Sugiyama	RPL7A SURF-3 SURF3	RLKVPPAINQFtQALDRQTAtQLLKLAHKYRPEtKQEKKQR
P62495	Y345	Sugiyama	ETF1 ERF1 RF1 SUP45L1	NLDIMRYVLHCQGTEEEKILyLTPEQEKDKSHFTDKETGQE
P62701	T247	Sugiyama	RPS4X CCG2 RPS4 SCAR	VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	Y242	Sugiyama	ACTA2 ACTSA ACTVS GIG46	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62753	S235	GPS6	RPS6 OK/SW-cl.2	KRMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK______
P62753	S236	GPS6	RPS6 OK/SW-cl.2	RMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK_______
P62753	Y156	Sugiyama	RPS6 OK/SW-cl.2	KRASRIRKLFNLsKEDDVRQyVVRKPLNKEGKKPRTKAPKI
P62805	S48	Sugiyama	H4C1 H4/A H4FA HIST1H4A; H4C2 H4/I H4FI HIST1H4B; H4C3 H4/G H4FG HIST1H4C; H4C4 H4/B H4FB HIST1H4D; H4C5 H4/J H4FJ HIST1H4E; H4C6 H4/C H4FC HIST1H4F; H4C8 H4/H H4FH HIST1H4H; H4C9 H4/M H4FM HIST1H4I; H4C11 H4/E H4FE HIST1H4J; H4C12 H4/D H4FD HIST1H4K; H4C13 H4/K H4FK HIST1H4L; H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A; H4C15 H4/O H4FO HIST2H4B; H4C16 H4-16 HIST4H4	QGItKPAIRRLARRGGVKRIsGLIyEETRGVLKVFLENVIR
P62807	S37	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807	Y38	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	AVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssK
P62826	T66	Sugiyama	RAN ARA24 OK/SW-cl.81	EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62879	Y145	Sugiyama	GNB2	SLKTREGNVRVsRELPGHtGyLSCCRFLDDNQIITSSGDTT
P62899	S15	Sugiyama	RPL31	______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62937	T157	Sugiyama	PPIA CYPA	NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62979	S57	Sugiyama	RPS27A UBA80 UBCEP1	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987	S57	Sugiyama	UBA52 UBCEP2	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63146	S142	Sugiyama	UBE2B RAD6B UBCH1	ANSQAAQLYQENKREYEKRVsAIVEQsWNDS__________
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	T304	Sugiyama	ACTG1 ACTG	KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P63261	Y240	Sugiyama	ACTG1 ACTG	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	Y241	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	Y242	Sugiyama	ACTC1 ACTC	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68104	T261	Sugiyama	EEF1A1 EEF1A EF1A LENG7	PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
P68104	T432	Sugiyama	EEF1A1 EEF1A EF1A LENG7	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	Y242	Sugiyama	ACTA1 ACTA	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363	Y312	Sugiyama	TUBA1B	tNACFEPANQMVKCDPRHGKyMACCLLyRGDVVPKDVNAAI
P68366	Y312	Sugiyama	TUBA4A TUBA1	tNACFEPANQMVKCDPRHGKyMACCLLyRGDVVPKDVNAAI
P68431	T46	Sugiyama	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
P84243	T46	Sugiyama	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	ARKsAPsTGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q00613	S230	EPSD\|PSP	HSF1 HSTF1	PLMLNDsGsAHSMPKYSRQFsLEHVHGSGPYSAPSPAYSSS
Q00839	Y257	Sugiyama	HNRNPU C1orf199 HNRPU SAFA U21.1	QKGGDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVE
Q00839	Y260	Sugiyama	HNRNPU C1orf199 HNRPU SAFA U21.1	GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01105	S168	Sugiyama	SET	ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q02543	S123	Sugiyama	RPL18A	AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q02878	T118	Sugiyama	RPL6 TXREB1	GDKNGGTRVVKLRKMPRyyPtEDVPRKLLSHGKKPFSQHVR
Q02878	Y116	Sugiyama	RPL6 TXREB1	VGGDKNGGTRVVKLRKMPRyyPtEDVPRKLLSHGKKPFSQH
Q04917	S64	Sugiyama	YWHAH YWHA1	LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA
Q04917	T31	Sugiyama	YWHAH YWHA1	ARLAEQAERyDDMAsAMKAVtELNEPLsNEDRNLLsVAyKN
Q05639	T261	Sugiyama	EEF1A2 EEF1AL STN	PTDKPLRLPLQDVyKIGGIGtVPVGRVETGILRPGMVVTFA
Q05639	T432	Sugiyama	EEF1A2 EEF1AL STN	VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06323	S55	Sugiyama	PSME1 IFI5111	KKIsELDAFLKEPALNEANLsNLKAPLDIPVPDPVKEKEKE
Q06830	Y116	Sugiyama	PRDX1 PAGA PAGB TDPX2	GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q12792	T345	Sugiyama	TWF1 PTK9	KPKGPAGKRGIRRLIRGPAEtEAttD_______________
Q12965	T936	Sugiyama	MYO1E MYO1C	LQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAP
Q13224	S1303	EPSD\|PSP	GRIN2B NMDAR2B	QSPTNSKAQKKNRNKLRRQHsYDTFVDLQKEEAALAPRSVs
Q13442	S19	Sugiyama	PDAP1 HASPP28	__MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442	T18	Sugiyama	PDAP1 HASPP28	___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13526	S71	GPS6\|EPSD\|PSP	PIN1	EPARVRCSHLLVKHsQSRRPsSWRQEKITRTKEEALELING
Q13765	Y120	Sugiyama	NACA HSD48	KNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAAA
Q14152	S1028	Sugiyama	EIF3A EIF3S10 KIAA0139	NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14240	Y71	Sugiyama	EIF4A2 DDX2B EIF4F	yGFEKPsAIQQRAIIPCIKGyDVIAQAQsGtGKTATFAISI
Q14457	T119	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	BECN1 GT197	LIGEASDGGtMENLSRRLKVtGDLFDIMSGQTDVDHPLCEE
Q14568	S53	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14568	Y283	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q15029	S944	Sugiyama	EFTUD2 KIAA0031 SNRP116	QPAPHLAREFMIKTRRRKGLsEDVsIsKFFDDPMLLELAKQ
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15642	S298	Sugiyama	TRIP10 CIP4 STOT STP	RPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRT
Q16623	S188	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	STX1A STX1	MLESGNPAIFASGIIMDSSIsKQALSEIETRHSEIIKLENS
Q16658	Y493	Sugiyama	FSCN1 FAN1 HSN SNL	DHAGVLKASAEtVDPAsLWEy____________________
Q16695	T46	Sugiyama	H3-4 H3FT HIST3H3	ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q16778	S37	Sugiyama	H2BC21 H2BFQ HIST2H2BE	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q16778	Y38	Sugiyama	H2BC21 H2BFQ HIST2H2BE	AVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssK
Q562R1	Y241	Sugiyama	ACTBL2	ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF8	Y198	Sugiyama	HSP90AB2P HSP90BB	DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q58FG0	Y177	Sugiyama	HSP90AA5P HSP90AE	GQLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQ
Q58FG1	T28	Sugiyama	HSP90AA4P HSP90AD HSPCAL2	SKLDSGKEPHISLIPNKQDRtLtIVDtGIGMTKADLINNLG
Q58FG1	T30	Sugiyama	HSP90AA4P HSP90AD HSPCAL2	LDSGKEPHISLIPNKQDRtLtIVDtGIGMTKADLINNLGTI
Q5QNW6	S37	Sugiyama	H2BC18 HIST2H2BF	KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6	Y38	Sugiyama	H2BC18 HIST2H2BF	AVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q5T5C0	S692	Sugiyama	STXBP5 LLGL3	YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q5VTE0	T261	Sugiyama	EEF1A1P5 EEF1AL3	PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
Q5VTE0	T432	Sugiyama	EEF1A1P5 EEF1AL3	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6DN03	S37	Sugiyama	H2BC20P HIST2H2BC	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DN03	Y38	Sugiyama	H2BC20P HIST2H2BC	AVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCK
Q6DRA6	S37	Sugiyama	H2BC19P HIST2H2BD	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DRA6	Y38	Sugiyama	H2BC19P HIST2H2BD	AVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCK
Q6NXT2	T45	Sugiyama	H3-5 H3F3C	AARKSTPSTCGVKPHRyRPGtVALREIRRYQKstELLIRKL
Q6PCE3	S175	Sugiyama	PGM2L1 BM32A	PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6S8J3	Y940	Sugiyama	POTEE A26C1A POTE2	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71DI3	T46	Sugiyama	H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D	ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q71U36	Y312	Sugiyama	TUBA1A TUBA3	tNACFEPANQMVKCDPRHGKyMACCLLyRGDVVPKDVNAAI
Q71UM5	T74	Sugiyama	RPS27L	VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q7Z417	S655	Sugiyama	NUFIP2 KIAA1321 PIG1	LGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsIWNL
Q86UE4	T317	Sugiyama	MTDH AEG1 LYRIC	IsAGEEKWNsVsPAsAGKRKtEPSAWsQDtGDANtNGKDWG
Q86UF2	S138	Sugiyama	CTAGE6 CTAGE6P	EKAAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKS
Q86V48	T958	Sugiyama	LUZP1	TRIGKNVESTNSNAytQRsstDFsELEQPRSCLFEQGTRRV
Q86W56	Y832	Sugiyama	PARG	DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8IX94	S138	Sugiyama	CTAGE4	EKAAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKS
Q8N257	S37	Sugiyama	H2BC26 H2BU1 HIST3H2BB	KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss
Q8N257	Y38	Sugiyama	H2BC26 H2BU1 HIST3H2BB	AVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssK
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8TAQ2	T278	Sugiyama	SMARCC2 BAF170	EVNDDKNPVSRRKKISAKtLtDEVNsPDsDRRDKKGGNYKK
Q8TD47	T247	Sugiyama	RPS4Y2 RPS4Y2P	VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8WWI1	S704	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	KKRLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEM
Q8WWI1	S706	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	RLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQK
Q92766	S1167	Sugiyama	RREB1 FINB	AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q93079	S37	Sugiyama	H2BC9 H2BFJ HIST1H2BH	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079	Y38	Sugiyama	H2BC9 H2BFJ HIST1H2BH	AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q96FA3	S39	SIGNOR\|PSP	PELI1 PRISM	ELIVLGYNGSLPNGDRGRRKsRFALFKRPKANGVKPSTVHI
Q96IZ0	S162	Sugiyama	PAWR PAR4	PSARKGKGQIEKRKLREKRRstGVVNIPAAECLDEyEDDEA
Q96IZ0	T163	Sugiyama	PAWR PAR4	SARKGKGQIEKRKLREKRRstGVVNIPAAECLDEyEDDEAG
Q96RR4	S511	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CAMKK2 CAMKKB KIAA0787	IRKRsFGNPFEGsRREERSLsAPGNLLTKKPTRECESLSEL
Q96RS6	S373	Sugiyama	NUDCD1 CML66	EGLTWPELVIGDKQGELIRDsAQCAAIAERLMHLtsEELNP
Q99614	S90	Sugiyama	TTC1 TPR1	FEEEPGADKVENKsNEDVNssELDEEyLIELEKNMSDEEKQ
Q99733	S22	Sugiyama	NAP1L4 NAP2	ADHsFsDGVPsDsVEAAKNAsNtEKLtDQVMQNPRVLAALQ
Q99733	T24	Sugiyama	NAP1L4 NAP2	HsFsDGVPsDsVEAAKNAsNtEKLtDQVMQNPRVLAALQER
Q99733	T28	Sugiyama	NAP1L4 NAP2	DGVPsDsVEAAKNAsNtEKLtDQVMQNPRVLAALQERLDNV
Q99733	Y55	Sugiyama	NAP1L4 NAP2	PRVLAALQERLDNVPHtPssyIEtLPKAVKRRINALKQLQV
Q99877	S37	Sugiyama	H2BC15 H2BFD HIST1H2BN	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877	Y38	Sugiyama	H2BC15 H2BFD HIST1H2BN	AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99879	S37	Sugiyama	H2BC14 H2BFE HIST1H2BM	KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879	Y38	Sugiyama	H2BC14 H2BFE HIST1H2BM	AINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99880	S37	Sugiyama	H2BC13 H2BFC HIST1H2BL	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880	Y38	Sugiyama	H2BC13 H2BFC HIST1H2BL	AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q9BQE3	Y312	Sugiyama	TUBA1C TUBA6	TNACFEPANQMVKCDPRHGKyMACCLLyRGDVVPKDVNAAI
Q9BYX7	Y240	Sugiyama	POTEKP ACTBL3 FKSG30	ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9H2G2	S340	Sugiyama	SLK KIAA0204 STK2	EEDEEEEtENsLPIPAsKRAssDLsIAssEEDKLsQNACIL
Q9H788	S315	Sugiyama	SH2D4A PPP1R38 SH2A	LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H788	S316	Sugiyama	SH2D4A PPP1R38 SH2A	NSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRAG
Q9HAV0	Y145	Sugiyama	GNB4	NLKTREGNVRVsRELPGHtGyLSCCRFLDDSQIVTSSGDTT
Q9NRZ9	T166	Sugiyama	HELLS PASG SMARCA6 Nbla10143	EILSVAKKNKKENEDENssstNLCVEDLQKNKDSNSIIKDR
Q9NUU7	T467	Sugiyama	DDX19A DDX19L	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UBP6	S27	Sugiyama	METTL1 C12orf1	NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGV2	S333	Sugiyama	NDRG3	MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UGV2	S334	Sugiyama	NDRG3	GYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDG
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UHD1	T204	Sugiyama	CHORDC1 CHP1	IFHEGMKYWSCCRRKtsDFNtFLAQEGCtKGKHMWTKKDAG
Q9UJ70	S76	Sugiyama	NAGK	AKRKAGVDPLVPLRsLGLsLsGGDQEDAGRILIEELRDRFP
Q9UMR2	T468	Sugiyama	DDX19B DBP5 DDX19 TDBP	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ80	T377	Sugiyama	PA2G4 EBP1	LLQssAsRKtQKKKKKKAsKtAENAtsGEtLEENEAGD___
Q9UQ80	T386	Sugiyama	PA2G4 EBP1	tQKKKKKKAsKtAENAtsGEtLEENEAGD____________
Q9Y266	S277	Sugiyama	NUDC	LVssDPEINtKKINPENsKLsDLDsEtRsMVEKMMYDQRQK
Q9Y2B0	S116	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0	T79	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	NPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGEQIDPs
Q9Y2W1	S240	Sugiyama	THRAP3 BCLAF2 TRAP150	sKPWPDAtyGtGsAsRAsAVsELsPRERsPALKsPLQsVVV
Q9Y3D8	Y31	Sugiyama	AK6 CINAP AD-004 CGI-137	TPGVGKTTLGKELASKSGLKyINVGDLAREEQLYDGYDEEY

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Meiotic synapsis	R-HSA-1221632	1.237685e-09	8.907	0	0
Cell Cycle	R-HSA-1640170	1.332102e-08	7.875	0	0
Cell Cycle Checkpoints	R-HSA-69620	2.188455e-08	7.660	0	0
Packaging Of Telomere Ends	R-HSA-171306	7.802927e-08	7.108	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.076803e-07	6.968	0	0
Meiosis	R-HSA-1500620	1.378260e-07	6.861	0	0
Cellular Senescence	R-HSA-2559583	1.173866e-07	6.930	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.102220e-07	6.508	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	3.442220e-07	6.463	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	4.942869e-07	6.306	0	0
Chromatin modifying enzymes	R-HSA-3247509	6.302877e-07	6.200	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	6.023054e-07	6.220	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	5.957605e-07	6.225	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	7.559685e-07	6.121	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.111070e-06	5.954	0	0
Cleavage of the damaged purine	R-HSA-110331	1.556804e-06	5.808	0	0
Chromatin organization	R-HSA-4839726	2.073621e-06	5.683	0	0
Depurination	R-HSA-73927	1.955523e-06	5.709	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	2.016659e-06	5.695	0	0
Reproduction	R-HSA-1474165	2.282386e-06	5.642	0	0
G2/M DNA damage checkpoint	R-HSA-69473	2.348448e-06	5.629	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	3.072175e-06	5.513	0	0
Signal Transduction	R-HSA-162582	3.070005e-06	5.513	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	3.744292e-06	5.427	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.905148e-06	5.408	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.622198e-06	5.335	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	4.623574e-06	5.335	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	5.623166e-06	5.250	0	0
Depyrimidination	R-HSA-73928	5.623166e-06	5.250	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	5.709717e-06	5.243	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	6.481267e-06	5.188	0	0
DNA methylation	R-HSA-5334118	7.670627e-06	5.115	0	0
PRC2 methylates histones and DNA	R-HSA-212300	7.621121e-06	5.118	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.525474e-06	5.123	0	0
Cell Cycle, Mitotic	R-HSA-69278	9.836288e-06	5.007	0	0
Assembly of the pre-replicative complex	R-HSA-68867	1.007999e-05	4.997	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.385502e-05	4.858	0	0
Estrogen-dependent gene expression	R-HSA-9018519	1.529518e-05	4.815	0	0
DNA Double Strand Break Response	R-HSA-5693606	1.603361e-05	4.795	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.652272e-05	4.782	0	0
G2/M Checkpoints	R-HSA-69481	1.690278e-05	4.772	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.850881e-05	4.733	0	0
Meiotic recombination	R-HSA-912446	2.819770e-05	4.550	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	2.949828e-05	4.530	0	0
Defective pyroptosis	R-HSA-9710421	3.578326e-05	4.446	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.871927e-05	4.412	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	4.515099e-05	4.345	0	0
HDACs deacetylate histones	R-HSA-3214815	5.248762e-05	4.280	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	5.229014e-05	4.282	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.798833e-05	4.319	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	5.030818e-05	4.298	0	0
Nucleosome assembly	R-HSA-774815	5.030818e-05	4.298	0	0
DNA Replication Pre-Initiation	R-HSA-69002	7.287826e-05	4.137	0	0
Mitotic Prophase	R-HSA-68875	7.920266e-05	4.101	0	0
HATs acetylate histones	R-HSA-3214847	7.936464e-05	4.100	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	8.944990e-05	4.048	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	1.059899e-04	3.975	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.175072e-04	3.930	0	0
Germ layer formation at gastrulation	R-HSA-9754189	1.556623e-04	3.808	0	0
Homology Directed Repair	R-HSA-5693538	2.013051e-04	3.696	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.013051e-04	3.696	0	0
Telomere Maintenance	R-HSA-157579	2.137896e-04	3.670	0	0
ESR-mediated signaling	R-HSA-8939211	2.398870e-04	3.620	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	2.694327e-04	3.570	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	4.095617e-04	3.388	0	0
M Phase	R-HSA-68886	3.922521e-04	3.406	0	0
Axon guidance	R-HSA-422475	4.155742e-04	3.381	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	4.570627e-04	3.340	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	4.754849e-04	3.323	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	4.806063e-04	3.318	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.082120e-04	3.294	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	6.052903e-04	3.218	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	6.052903e-04	3.218	0	0
Signaling by Hippo	R-HSA-2028269	6.463480e-04	3.190	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	6.535462e-04	3.185	0	0
Chromosome Maintenance	R-HSA-73886	7.371055e-04	3.132	0	0
Nervous system development	R-HSA-9675108	8.420711e-04	3.075	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	8.334026e-04	3.079	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	8.503909e-04	3.070	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	8.578561e-04	3.067	0	0
Netrin-1 signaling	R-HSA-373752	8.618156e-04	3.065	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	8.618156e-04	3.065	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.001400e-03	2.999	0	0
Cell junction organization	R-HSA-446728	9.564762e-04	3.019	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.100071e-03	2.959	0	0
Apoptotic execution phase	R-HSA-75153	1.116824e-03	2.952	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.239562e-03	2.907	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.430875e-03	2.844	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	1.397818e-03	2.855	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.493013e-03	2.826	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.487650e-03	2.827	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.529599e-03	2.815	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.864532e-03	2.729	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.998742e-03	2.699	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.998742e-03	2.699	0	0
Semaphorin interactions	R-HSA-373755	2.086172e-03	2.681	0	0
Diseases of programmed cell death	R-HSA-9645723	2.295430e-03	2.639	0	0
Cell-Cell communication	R-HSA-1500931	2.563909e-03	2.591	0	0
Base Excision Repair	R-HSA-73884	2.701913e-03	2.568	0	0
Regulation of endogenous retroelements	R-HSA-9842860	2.858881e-03	2.544	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	2.900663e-03	2.538	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.900663e-03	2.538	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.900663e-03	2.538	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	3.202336e-03	2.495	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	3.174737e-03	2.498	0	0
DNA Replication	R-HSA-69306	3.202336e-03	2.495	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	3.094833e-03	2.509	0	0
EPH-Ephrin signaling	R-HSA-2682334	3.419576e-03	2.466	0	0
Amyloid fiber formation	R-HSA-977225	3.451785e-03	2.462	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	3.552944e-03	2.449	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	3.552944e-03	2.449	0	0
Sema4D in semaphorin signaling	R-HSA-400685	3.577916e-03	2.446	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	4.027190e-03	2.395	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	4.424449e-03	2.354	0	0
Ub-specific processing proteases	R-HSA-5689880	4.487021e-03	2.348	0	0
Cell-cell junction organization	R-HSA-421270	4.790408e-03	2.320	0	0
Adherens junctions interactions	R-HSA-418990	4.483112e-03	2.348	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	5.564780e-03	2.255	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.579979e-03	2.253	0	0
Protein ubiquitination	R-HSA-8852135	6.129990e-03	2.213	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	6.423093e-03	2.192	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.637804e-03	2.178	0	0
RNA Polymerase I Transcription	R-HSA-73864	7.750866e-03	2.111	0	0
PKMTs methylate histone lysines	R-HSA-3214841	7.781044e-03	2.109	0	0
Signaling by WNT	R-HSA-195721	8.475930e-03	2.072	0	0
Regulation of TP53 Activity	R-HSA-5633007	1.029167e-02	1.988	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.172329e-02	1.931	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	1.172329e-02	1.931	0	0
mTORC1-mediated signalling	R-HSA-166208	1.049514e-02	1.979	0	0
EPHB-mediated forward signaling	R-HSA-3928662	1.167072e-02	1.933	0	0
Gene Silencing by RNA	R-HSA-211000	1.088123e-02	1.963	0	0
Oncogenic MAPK signaling	R-HSA-6802957	1.280776e-02	1.893	0	0
RAF activation	R-HSA-5673000	1.307897e-02	1.883	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.474278e-02	1.831	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.535204e-02	1.814	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.535204e-02	1.814	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.535204e-02	1.814	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	1.611577e-02	1.793	0	0
RET signaling	R-HSA-8853659	1.613528e-02	1.792	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	1.893718e-02	1.723	0	0
Calcineurin activates NFAT	R-HSA-2025928	1.893718e-02	1.723	0	0
Unwinding of DNA	R-HSA-176974	1.893718e-02	1.723	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.216916e-02	1.654	0	0
G alpha (12/13) signalling events	R-HSA-416482	2.057988e-02	1.687	0	0
Epigenetic regulation of gene expression	R-HSA-212165	1.961026e-02	1.708	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.001796e-02	1.699	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.317499e-02	1.635	0	0
PIP3 activates AKT signaling	R-HSA-1257604	2.400780e-02	1.620	0	0
S Phase	R-HSA-69242	2.520560e-02	1.599	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.527643e-02	1.597	0	0
Activation of the pre-replicative complex	R-HSA-68962	2.745130e-02	1.561	0	0
Interleukin-37 signaling	R-HSA-9008059	2.745130e-02	1.561	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	2.817571e-02	1.550	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.850760e-02	1.545	0	0
Gene expression (Transcription)	R-HSA-74160	2.929534e-02	1.533	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	3.213804e-02	1.493	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.346280e-02	1.475	0	0
Amplification of signal from the kinetochores	R-HSA-141424	3.346280e-02	1.475	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	3.343180e-02	1.476	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	3.213804e-02	1.493	0	0
RNA Polymerase II Transcription	R-HSA-73857	3.089296e-02	1.510	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	3.583389e-02	1.446	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.585267e-02	1.445	0	0
Intracellular signaling by second messengers	R-HSA-9006925	3.401354e-02	1.468	0	0
Deubiquitination	R-HSA-5688426	3.473415e-02	1.459	0	0
NRAGE signals death through JNK	R-HSA-193648	3.147712e-02	1.502	0	0
HCMV Late Events	R-HSA-9610379	3.662058e-02	1.436	0	0
Activation of ATR in response to replication stress	R-HSA-176187	3.670250e-02	1.435	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.734286e-02	1.428	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	3.926671e-02	1.406	0	0
Repression of WNT target genes	R-HSA-4641265	3.926671e-02	1.406	0	0
Signaling by ERBB4	R-HSA-1236394	3.963221e-02	1.402	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	4.085988e-02	1.389	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	4.185045e-02	1.378	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	4.185045e-02	1.378	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	4.185045e-02	1.378	0	0
Signaling by RAS mutants	R-HSA-6802949	4.185045e-02	1.378	0	0
IRS activation	R-HSA-74713	4.244959e-02	1.372	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.244959e-02	1.372	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.266421e-02	1.370	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	4.555958e-02	1.341	0	0
HCMV Early Events	R-HSA-9609690	4.622621e-02	1.335	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.381099e-02	1.269	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	5.593061e-02	1.252	0	0
Regulation of TP53 Degradation	R-HSA-6804757	5.169842e-02	1.287	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.381099e-02	1.269	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	5.325969e-02	1.274	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	5.176175e-02	1.286	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	5.176175e-02	1.286	0	0
Mitotic Anaphase	R-HSA-68882	5.218280e-02	1.282	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.382625e-02	1.269	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	4.689582e-02	1.329	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.766007e-02	1.322	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	5.381099e-02	1.269	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.593061e-02	1.252	0	0
Generic Transcription Pathway	R-HSA-212436	4.913458e-02	1.309	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	5.377314e-02	1.269	0	0
Signaling by ALK in cancer	R-HSA-9700206	5.377314e-02	1.269	0	0
HDMs demethylate histones	R-HSA-3214842	5.770682e-02	1.239	0	0
DCC mediated attractive signaling	R-HSA-418885	5.953147e-02	1.225	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.953147e-02	1.225	0	0
Formation of the anterior neural plate	R-HSA-9823739	5.953147e-02	1.225	0	0
Cell-extracellular matrix interactions	R-HSA-446353	5.953147e-02	1.225	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	6.133364e-02	1.212	0	0
mRNA 3'-end processing	R-HSA-72187	6.299030e-02	1.201	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	6.327376e-02	1.199	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	6.327376e-02	1.199	0	0
Cellular responses to stress	R-HSA-2262752	6.446679e-02	1.191	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.497581e-02	1.187	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	6.497581e-02	1.187	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	6.497581e-02	1.187	0	0
G1/S Transition	R-HSA-69206	6.519847e-02	1.186	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	6.610632e-02	1.180	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	7.922798e-02	1.101	0	0
SOS-mediated signalling	R-HSA-112412	7.922798e-02	1.101	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	7.922798e-02	1.101	0	0
Telomere Extension By Telomerase	R-HSA-171319	7.521738e-02	1.124	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.158504e-02	1.088	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	7.539019e-02	1.123	0	0
MAP2K and MAPK activation	R-HSA-5674135	7.998254e-02	1.097	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	8.002289e-02	1.097	0	0
Separation of Sister Chromatids	R-HSA-2467813	8.564452e-02	1.067	0	0
HCMV Infection	R-HSA-9609646	8.277680e-02	1.082	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	7.998254e-02	1.097	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	7.922798e-02	1.101	0	0
MTOR signalling	R-HSA-165159	8.536235e-02	1.069	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	7.525807e-02	1.123	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	7.922798e-02	1.101	0	0
Switching of origins to a post-replicative state	R-HSA-69052	8.599134e-02	1.066	0	0
Muscle contraction	R-HSA-397014	7.827025e-02	1.106	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	7.806211e-02	1.108	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	7.922798e-02	1.101	0	0
PI Metabolism	R-HSA-1483255	8.378800e-02	1.077	0	0
Specification of primordial germ cells	R-HSA-9827857	8.373892e-02	1.077	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	7.806211e-02	1.108	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	6.950757e-02	1.158	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	8.599134e-02	1.066	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	8.820951e-02	1.054	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	8.849600e-02	1.053	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	8.849600e-02	1.053	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	8.849600e-02	1.053	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	8.849600e-02	1.053	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	8.849600e-02	1.053	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	8.849600e-02	1.053	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	8.849600e-02	1.053	0	0
Co-inhibition by PD-1	R-HSA-389948	8.980609e-02	1.047	0	0
Signaling by FGFR in disease	R-HSA-1226099	9.025418e-02	1.045	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	9.260765e-02	1.033	0	0
Ephrin signaling	R-HSA-3928664	9.260765e-02	1.033	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	9.260765e-02	1.033	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	9.299085e-02	1.032	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	9.307619e-02	1.031	0	0
Activation of RAS in B cells	R-HSA-1169092	9.307619e-02	1.031	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	9.307619e-02	1.031	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	9.307619e-02	1.031	0	0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	1.297661e-01	0.887	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	1.297661e-01	0.887	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	1.297661e-01	0.887	0	0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	1.297661e-01	0.887	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	1.297661e-01	0.887	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	1.297661e-01	0.887	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	1.297661e-01	0.887	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	1.297661e-01	0.887	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.225892e-01	0.912	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.018454e-01	0.992	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.018454e-01	0.992	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.114326e-01	0.953	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.114326e-01	0.953	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.114326e-01	0.953	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.114326e-01	0.953	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	1.087051e-01	0.964	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.045741e-01	0.981	0	0
mRNA Splicing	R-HSA-72172	1.030674e-01	0.987	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.072454e-01	0.970	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.075585e-01	0.968	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.282158e-01	0.892	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	1.075585e-01	0.968	0	0
PI3K/AKT activation	R-HSA-198203	1.225892e-01	0.912	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.022042e-01	0.991	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	1.249548e-01	0.903	0	0
Resolution of D-Loop Structures	R-HSA-5693537	1.171469e-01	0.931	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.095607e-01	0.960	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.095607e-01	0.960	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.330121e-01	0.876	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	1.249548e-01	0.903	0	0
PI3K Cascade	R-HSA-109704	1.348059e-01	0.870	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	1.095607e-01	0.960	0	0
Signal attenuation	R-HSA-74749	1.225892e-01	0.912	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.140107e-01	0.943	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	1.153752e-01	0.938	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.075585e-01	0.968	1	1
Breakdown of the nuclear lamina	R-HSA-352238	1.297661e-01	0.887	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.075585e-01	0.968	0	0
Co-stimulation by CD28	R-HSA-389356	1.214260e-01	0.916	0	0
Developmental Biology	R-HSA-1266738	1.249759e-01	0.903	0	0
Rap1 signalling	R-HSA-392517	1.018454e-01	0.992	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	1.329762e-01	0.876	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.075585e-01	0.968	0	0
Signaling by Leptin	R-HSA-2586552	1.225892e-01	0.912	0	0
IRE1alpha activates chaperones	R-HSA-381070	1.013979e-01	0.994	0	0
Apoptosis	R-HSA-109581	1.367025e-01	0.864	1	0
Formation of the posterior neural plate	R-HSA-9832991	1.380892e-01	0.860	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	1.380892e-01	0.860	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	1.412026e-01	0.850	0	0
RNA Polymerase III Transcription	R-HSA-74158	1.412026e-01	0.850	0	0
FLT3 signaling in disease	R-HSA-9682385	1.412026e-01	0.850	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	1.420908e-01	0.847	0	0
FOXO-mediated transcription	R-HSA-9614085	1.428746e-01	0.845	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.451822e-01	0.838	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	1.488097e-01	0.827	0	0
Orc1 removal from chromatin	R-HSA-68949	1.488097e-01	0.827	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.502113e-01	0.823	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	1.539853e-01	0.813	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.539853e-01	0.813	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.560337e-01	0.807	0	0
Smooth Muscle Contraction	R-HSA-445355	1.560337e-01	0.807	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.572768e-01	0.803	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	1.582349e-01	0.801	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	1.582349e-01	0.801	0	0
Rab regulation of trafficking	R-HSA-9007101	1.591137e-01	0.798	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.691700e-01	0.772	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.691700e-01	0.772	0	0
Interaction between PHLDA1 and AURKA	R-HSA-8854521	1.691700e-01	0.772	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	1.691700e-01	0.772	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	1.691700e-01	0.772	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	1.691700e-01	0.772	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.691700e-01	0.772	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.691700e-01	0.772	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.691700e-01	0.772	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.691700e-01	0.772	0	0
Potassium transport channels	R-HSA-1296067	1.691700e-01	0.772	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	1.691700e-01	0.772	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.691700e-01	0.772	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.691700e-01	0.772	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.691700e-01	0.772	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.691700e-01	0.772	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.691700e-01	0.772	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	1.691700e-01	0.772	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.067920e-01	0.684	0	0
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	2.067920e-01	0.684	0	0
Invadopodia formation	R-HSA-8941237	2.067920e-01	0.684	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.427126e-01	0.615	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	2.427126e-01	0.615	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.427126e-01	0.615	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.770086e-01	0.558	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.770086e-01	0.558	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.702101e-01	0.769	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	3.097533e-01	0.509	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	3.097533e-01	0.509	0	0
PDE3B signalling	R-HSA-165160	3.097533e-01	0.509	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	3.097533e-01	0.509	0	0
PKB-mediated events	R-HSA-109703	3.097533e-01	0.509	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.097533e-01	0.509	0	0
Signaling by RNF43 mutants	R-HSA-5340588	3.097533e-01	0.509	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.867013e-01	0.729	0	0
Erythropoietin activates STAT5	R-HSA-9027283	3.410170e-01	0.467	0	0
STAT5 Activation	R-HSA-9645135	3.410170e-01	0.467	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	3.410170e-01	0.467	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.410170e-01	0.467	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.410170e-01	0.467	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.202584e-01	0.657	0	0
Deadenylation of mRNA	R-HSA-429947	1.639064e-01	0.785	0	0
Phosphorylation of the APC/C	R-HSA-176412	2.372234e-01	0.625	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.372234e-01	0.625	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	3.708664e-01	0.431	0	0
Netrin mediated repulsion signals	R-HSA-418886	3.708664e-01	0.431	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.708664e-01	0.431	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	3.708664e-01	0.431	0	0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	3.708664e-01	0.431	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	3.708664e-01	0.431	0	0
Disinhibition of SNARE formation	R-HSA-114516	3.708664e-01	0.431	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.751662e-01	0.757	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.542524e-01	0.595	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.542524e-01	0.595	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	1.982897e-01	0.703	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	2.713047e-01	0.567	0	0
Type I hemidesmosome assembly	R-HSA-446107	3.993655e-01	0.399	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	3.993655e-01	0.399	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.101143e-01	0.678	0	0
Formation of the Early Elongation Complex	R-HSA-113418	2.101143e-01	0.678	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	2.883435e-01	0.540	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.053350e-01	0.515	0	0
WNT mediated activation of DVL	R-HSA-201688	4.265752e-01	0.370	0	0
Signaling by RAF1 mutants	R-HSA-9656223	1.943600e-01	0.711	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.037654e-01	0.691	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	3.222487e-01	0.492	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.711226e-01	0.567	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.390568e-01	0.470	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.525539e-01	0.344	0	0
Striated Muscle Contraction	R-HSA-390522	2.835790e-01	0.547	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.835790e-01	0.547	0	0
FGFR2 alternative splicing	R-HSA-6803529	3.722583e-01	0.429	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.722583e-01	0.429	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.773571e-01	0.321	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.773571e-01	0.321	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.773571e-01	0.321	0	0
Interleukin receptor SHC signaling	R-HSA-912526	3.886089e-01	0.410	0	0
HSF1-dependent transactivation	R-HSA-3371571	2.931492e-01	0.533	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.137634e-01	0.503	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.587912e-01	0.445	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	3.712785e-01	0.430	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	3.712785e-01	0.430	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	3.228092e-01	0.491	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	4.519414e-01	0.345	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	4.519414e-01	0.345	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	4.519414e-01	0.345	0	0
Centrosome maturation	R-HSA-380287	3.408574e-01	0.467	0	0
snRNP Assembly	R-HSA-191859	3.760791e-01	0.425	0	0
Metabolism of non-coding RNA	R-HSA-194441	3.760791e-01	0.425	0	0
HIV elongation arrest and recovery	R-HSA-167287	4.671896e-01	0.331	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	4.671896e-01	0.331	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	3.680484e-01	0.434	0	0
AURKA Activation by TPX2	R-HSA-8854518	4.480081e-01	0.349	0	0
HIV Transcription Elongation	R-HSA-167169	3.712785e-01	0.430	0	0
Formation of definitive endoderm	R-HSA-9823730	3.222487e-01	0.492	0	0
Extension of Telomeres	R-HSA-180786	3.760791e-01	0.425	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	3.712785e-01	0.430	0	0
Cellular response to heat stress	R-HSA-3371556	2.912334e-01	0.536	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.982897e-01	0.703	0	0
Frs2-mediated activation	R-HSA-170968	1.867013e-01	0.729	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	1.867013e-01	0.729	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	4.525539e-01	0.344	0	0
Regulation of the apoptosome activity	R-HSA-9627069	4.525539e-01	0.344	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.337242e-01	0.477	0	0
Signaling by ERBB2	R-HSA-1227986	3.864534e-01	0.413	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.372234e-01	0.625	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.711226e-01	0.567	0	0
Formation of apoptosome	R-HSA-111458	4.525539e-01	0.344	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	2.960822e-01	0.529	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	3.587912e-01	0.445	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	2.341946e-01	0.630	0	0
Regulation of gap junction activity	R-HSA-191650	2.427126e-01	0.615	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	2.770086e-01	0.558	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	3.097533e-01	0.509	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	2.202584e-01	0.657	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.993655e-01	0.399	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	3.557342e-01	0.449	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	2.184653e-01	0.661	0	0
Pyroptosis	R-HSA-5620971	2.101143e-01	0.678	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.318219e-01	0.479	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	3.760791e-01	0.425	0	0
Prolonged ERK activation events	R-HSA-169893	2.372234e-01	0.625	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.138247e-01	0.503	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	3.708664e-01	0.431	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.713047e-01	0.567	0	0
IRS-mediated signalling	R-HSA-112399	1.862912e-01	0.730	0	0
Amino acids regulate mTORC1	R-HSA-9639288	3.137634e-01	0.503	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.207186e-01	0.376	0	0
Tight junction interactions	R-HSA-420029	4.207186e-01	0.376	0	0
Aggrephagy	R-HSA-9646399	3.712785e-01	0.430	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	3.034370e-01	0.518	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	2.959624e-01	0.529	0	0
G1 Phase	R-HSA-69236	4.328113e-01	0.364	0	0
Cyclin D associated events in G1	R-HSA-69231	4.328113e-01	0.364	0	0
Interleukin-2 signaling	R-HSA-9020558	4.773571e-01	0.321	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	3.319823e-01	0.479	0	0
Signaling by WNT in cancer	R-HSA-4791275	2.587287e-01	0.587	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	2.517072e-01	0.599	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.770086e-01	0.558	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.097533e-01	0.509	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	2.713047e-01	0.567	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	3.722583e-01	0.429	0	0
Signaling by ROBO receptors	R-HSA-376176	2.349559e-01	0.629	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	2.695194e-01	0.569	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.850947e-01	0.733	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.285634e-01	0.368	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	4.172083e-01	0.380	0	0
IGF1R signaling cascade	R-HSA-2428924	2.436346e-01	0.613	0	0
Neurexins and neuroligins	R-HSA-6794361	3.034370e-01	0.518	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	4.519414e-01	0.345	0	0
Mitotic Prometaphase	R-HSA-68877	1.904918e-01	0.720	0	0
MET interacts with TNS proteins	R-HSA-8875513	2.067920e-01	0.684	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	3.097533e-01	0.509	0	0
Formation of the Editosome	R-HSA-75094	3.097533e-01	0.509	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.867013e-01	0.729	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	3.410170e-01	0.467	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	2.372234e-01	0.625	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	3.708664e-01	0.431	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.542524e-01	0.595	0	0
Co-stimulation by ICOS	R-HSA-9927354	3.993655e-01	0.399	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	3.053350e-01	0.515	0	0
Signaling by APC mutants	R-HSA-4839744	4.773571e-01	0.321	0	0
Cristae formation	R-HSA-8949613	4.519414e-01	0.345	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	4.671896e-01	0.331	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.861956e-01	0.413	0	0
Insulin receptor signalling cascade	R-HSA-74751	2.436346e-01	0.613	0	0
RAF/MAP kinase cascade	R-HSA-5673001	1.940097e-01	0.712	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.521911e-01	0.598	0	0
Apoptotic factor-mediated response	R-HSA-111471	2.883435e-01	0.540	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.862912e-01	0.730	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	1.639064e-01	0.785	0	0
Signaling by TGFB family members	R-HSA-9006936	4.419607e-01	0.355	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	2.194570e-01	0.659	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	3.993655e-01	0.399	0	0
Kinesins	R-HSA-983189	2.102618e-01	0.677	0	0
Protein-protein interactions at synapses	R-HSA-6794362	2.643986e-01	0.578	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.567011e-01	0.591	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.097533e-01	0.509	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.708664e-01	0.431	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	3.993655e-01	0.399	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	4.525539e-01	0.344	0	0
RAB geranylgeranylation	R-HSA-8873719	2.102618e-01	0.677	0	0
Heme signaling	R-HSA-9707616	2.267658e-01	0.644	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	4.364474e-01	0.360	0	0
Autophagy	R-HSA-9612973	1.891364e-01	0.723	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	3.722583e-01	0.429	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	1.759791e-01	0.755	0	0
ISG15 antiviral mechanism	R-HSA-1169408	3.408574e-01	0.467	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.174161e-01	0.379	0	0
Membrane Trafficking	R-HSA-199991	2.014784e-01	0.696	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	4.206584e-01	0.376	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	4.671896e-01	0.331	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.192158e-01	0.496	0	0
MAPK family signaling cascades	R-HSA-5683057	1.922508e-01	0.716	0	0
DSCAM interactions	R-HSA-376172	1.691700e-01	0.772	0	0
CASP5-mediated substrate cleavage	R-HSA-9960525	2.067920e-01	0.684	0	0
Sensory perception of sour taste	R-HSA-9729555	2.427126e-01	0.615	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.770086e-01	0.558	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	3.097533e-01	0.509	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.034016e-01	0.692	0	0
Ca2+ activated K+ channels	R-HSA-1296052	3.708664e-01	0.431	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.542524e-01	0.595	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.982897e-01	0.703	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	3.993655e-01	0.399	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	3.993655e-01	0.399	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	3.993655e-01	0.399	0	0
ARMS-mediated activation	R-HSA-170984	4.265752e-01	0.370	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	4.525539e-01	0.344	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.525539e-01	0.344	0	0
Synthesis of PI	R-HSA-1483226	4.773571e-01	0.321	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	4.773571e-01	0.321	0	0
Glycosphingolipid transport	R-HSA-9845576	3.211690e-01	0.493	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.886089e-01	0.410	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	2.713047e-01	0.567	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	3.993655e-01	0.399	0	0
DNA Repair	R-HSA-73894	3.129706e-01	0.504	0	0
NGF-stimulated transcription	R-HSA-9031628	2.626046e-01	0.581	0	0
Ion homeostasis	R-HSA-5578775	1.785332e-01	0.748	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.227033e-01	0.652	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.410170e-01	0.467	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.711226e-01	0.567	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	4.525539e-01	0.344	0	0
Macroautophagy	R-HSA-1632852	3.129740e-01	0.504	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.542524e-01	0.595	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	4.364474e-01	0.360	0	0
Specification of the neural plate border	R-HSA-9834899	3.053350e-01	0.515	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	3.864534e-01	0.413	0	0
Programmed Cell Death	R-HSA-5357801	1.668447e-01	0.778	1	0
FLT3 Signaling	R-HSA-9607240	1.850947e-01	0.733	0	0
CASP4-mediated substrate cleavage	R-HSA-9960519	2.067920e-01	0.684	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.770086e-01	0.558	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	3.097533e-01	0.509	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	3.097533e-01	0.509	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	3.097533e-01	0.509	0	0
NADPH regeneration	R-HSA-389542	3.410170e-01	0.467	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	2.372234e-01	0.625	0	0
Glycoprotein hormones	R-HSA-209822	3.708664e-01	0.431	0	0
Regulation of PTEN localization	R-HSA-8948747	3.708664e-01	0.431	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	1.982897e-01	0.703	0	0
Adrenoceptors	R-HSA-390696	3.993655e-01	0.399	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.525539e-01	0.344	0	0
Bicarbonate transporters	R-HSA-425381	4.773571e-01	0.321	0	0
TGFBR3 expression	R-HSA-9839394	4.207186e-01	0.376	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.138247e-01	0.503	0	0
Signaling by NTRKs	R-HSA-166520	2.449548e-01	0.611	0	0
Cardiac conduction	R-HSA-5576891	2.458062e-01	0.609	0	0
Ion transport by P-type ATPases	R-HSA-936837	4.276625e-01	0.369	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.945866e-01	0.711	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	4.525539e-01	0.344	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	4.265752e-01	0.370	0	0
mRNA Editing	R-HSA-75072	4.265752e-01	0.370	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	2.835790e-01	0.547	0	0
Synthesis of DNA	R-HSA-69239	3.157043e-01	0.501	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.898507e-01	0.409	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	2.711226e-01	0.567	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.960822e-01	0.529	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	3.846181e-01	0.415	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	4.519414e-01	0.345	0	0
Diseases of DNA repair	R-HSA-9675135	2.425963e-01	0.615	0	0
Cellular responses to stimuli	R-HSA-8953897	2.168725e-01	0.664	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	3.097533e-01	0.509	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.202584e-01	0.657	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	3.708664e-01	0.431	0	0
Synthesis of PG	R-HSA-1483148	2.542524e-01	0.595	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	4.265752e-01	0.370	0	0
Interleukin-1 processing	R-HSA-448706	4.265752e-01	0.370	0	0
Protein hydroxylation	R-HSA-9629569	3.222487e-01	0.492	0	0
Basigin interactions	R-HSA-210991	3.390568e-01	0.470	0	0
Peptide hormone biosynthesis	R-HSA-209952	4.525539e-01	0.344	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	4.773571e-01	0.321	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.837194e-01	0.416	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	4.415237e-01	0.355	0	0
Signaling by VEGF	R-HSA-194138	4.715648e-01	0.326	0	0
Interleukin-7 signaling	R-HSA-1266695	1.751662e-01	0.757	0	0
Signaling by SCF-KIT	R-HSA-1433557	2.133012e-01	0.671	0	0
G1/S-Specific Transcription	R-HSA-69205	3.211690e-01	0.493	0	0
Adaptive Immune System	R-HSA-1280218	2.700693e-01	0.569	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	4.364474e-01	0.360	1	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.372234e-01	0.625	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.883435e-01	0.540	0	0
Tandem pore domain potassium channels	R-HSA-1296346	4.525539e-01	0.344	0	0
STING mediated induction of host immune responses	R-HSA-1834941	3.053350e-01	0.515	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	1.867013e-01	0.729	0	0
Cardiogenesis	R-HSA-9733709	2.711226e-01	0.567	0	0
TRP channels	R-HSA-3295583	1.866339e-01	0.729	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	4.265752e-01	0.370	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.557342e-01	0.449	0	0
Suppression of apoptosis	R-HSA-9635465	4.773571e-01	0.321	0	0
Signaling by ALK	R-HSA-201556	3.587912e-01	0.445	0	0
DNA strand elongation	R-HSA-69190	2.587287e-01	0.587	0	0
Prostanoid ligand receptors	R-HSA-391908	4.773571e-01	0.321	0	0
MITF-M-dependent gene expression	R-HSA-9856651	2.560590e-01	0.592	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	3.722583e-01	0.429	0	0
TNF signaling	R-HSA-75893	3.448918e-01	0.462	0	0
Regulation of CDH11 function	R-HSA-9762292	4.525539e-01	0.344	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	3.557342e-01	0.449	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.883435e-01	0.540	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	3.837194e-01	0.416	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	2.425963e-01	0.615	0	0
TBC/RABGAPs	R-HSA-8854214	4.206584e-01	0.376	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.770365e-01	0.557	0	0
Death Receptor Signaling	R-HSA-73887	1.798937e-01	0.745	0	0
Signaling by NOTCH	R-HSA-157118	3.223903e-01	0.492	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	4.352288e-01	0.361	0	0
Growth hormone receptor signaling	R-HSA-982772	3.886089e-01	0.410	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	2.515134e-01	0.599	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.780782e-01	0.321	0	0
G2/M Transition	R-HSA-69275	4.781959e-01	0.320	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.803985e-01	0.318	0	0
Stimuli-sensing channels	R-HSA-2672351	4.815585e-01	0.317	0	0
Signaling by Erythropoietin	R-HSA-9006335	4.821826e-01	0.317	0	0
mRNA Capping	R-HSA-72086	4.821826e-01	0.317	0	0
Late endosomal microautophagy	R-HSA-9615710	4.821826e-01	0.317	0	0
DARPP-32 events	R-HSA-180024	4.821826e-01	0.317	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.821826e-01	0.317	0	0
Platelet calcium homeostasis	R-HSA-418360	4.821826e-01	0.317	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	4.821826e-01	0.317	0	0
Regulation of gene expression in beta cells	R-HSA-210745	4.821826e-01	0.317	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	4.845436e-01	0.315	0	0
COPII-mediated vesicle transport	R-HSA-204005	4.879622e-01	0.312	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.879622e-01	0.312	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	4.879622e-01	0.312	0	0
Mitotic G2-G2/M phases	R-HSA-453274	4.902918e-01	0.310	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	4.920033e-01	0.308	0	0
Ion channel transport	R-HSA-983712	4.963148e-01	0.304	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	4.969121e-01	0.304	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.969121e-01	0.304	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	4.969121e-01	0.304	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.969121e-01	0.304	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.969121e-01	0.304	0	0
Regulation of mitotic cell cycle	R-HSA-453276	4.977690e-01	0.303	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	4.977690e-01	0.303	0	0
Activation of RAC1	R-HSA-428540	5.010380e-01	0.300	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	5.010380e-01	0.300	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	5.010380e-01	0.300	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	5.010380e-01	0.300	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	5.010380e-01	0.300	0	0
ERKs are inactivated	R-HSA-202670	5.010380e-01	0.300	0	0
Signaling by AMER1 mutants	R-HSA-4839748	5.010380e-01	0.300	0	0
Signaling by AXIN mutants	R-HSA-4839735	5.010380e-01	0.300	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.010380e-01	0.300	0	0
Sodium/Calcium exchangers	R-HSA-425561	5.010380e-01	0.300	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	5.034786e-01	0.298	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	5.074945e-01	0.295	0	0
Signaling by Insulin receptor	R-HSA-74752	5.104912e-01	0.292	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	5.113713e-01	0.291	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	5.113713e-01	0.291	0	0
Trafficking of AMPA receptors	R-HSA-399719	5.113713e-01	0.291	0	0
Budding and maturation of HIV virion	R-HSA-162588	5.113713e-01	0.291	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	5.113713e-01	0.291	0	0
Inositol phosphate metabolism	R-HSA-1483249	5.129436e-01	0.290	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	5.160222e-01	0.287	0	0
Potential therapeutics for SARS	R-HSA-9679191	5.169341e-01	0.287	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	5.171347e-01	0.286	0	0
Ca2+ pathway	R-HSA-4086398	5.171347e-01	0.286	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	5.236473e-01	0.281	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.236473e-01	0.281	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	5.236473e-01	0.281	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	5.236473e-01	0.281	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	5.236473e-01	0.281	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	5.236473e-01	0.281	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	5.236473e-01	0.281	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.236473e-01	0.281	0	0
Signaling by LTK	R-HSA-9842663	5.236473e-01	0.281	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.236473e-01	0.281	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.236473e-01	0.281	0	0
Disorders of Nervous System Development	R-HSA-9697154	5.236473e-01	0.281	0	0
Pervasive developmental disorders	R-HSA-9005895	5.236473e-01	0.281	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.236473e-01	0.281	0	0
Interleukin-15 signaling	R-HSA-8983432	5.236473e-01	0.281	0	0
OAS antiviral response	R-HSA-8983711	5.236473e-01	0.281	0	0
G0 and Early G1	R-HSA-1538133	5.255545e-01	0.279	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	5.260197e-01	0.279	0	0
Circadian clock	R-HSA-9909396	5.292754e-01	0.276	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	5.394569e-01	0.268	0	0
Nuclear RNA decay	R-HSA-9930044	5.394569e-01	0.268	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	5.394569e-01	0.268	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.394569e-01	0.268	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	5.394569e-01	0.268	0	0
Integrin signaling	R-HSA-354192	5.394569e-01	0.268	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.452335e-01	0.263	0	0
Formation of axial mesoderm	R-HSA-9796292	5.452335e-01	0.263	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	5.452335e-01	0.263	0	0
Chylomicron remodeling	R-HSA-8963901	5.452335e-01	0.263	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	5.452335e-01	0.263	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	5.452335e-01	0.263	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	5.452335e-01	0.263	0	0
Maturation of nucleoprotein	R-HSA-9683610	5.452335e-01	0.263	0	0
Translation initiation complex formation	R-HSA-72649	5.479836e-01	0.261	0	0
COPI-mediated anterograde transport	R-HSA-6807878	5.524879e-01	0.258	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	5.530749e-01	0.257	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.530749e-01	0.257	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	5.530749e-01	0.257	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	5.547721e-01	0.256	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.658427e-01	0.247	0	0
CRMPs in Sema3A signaling	R-HSA-399956	5.658427e-01	0.247	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.658427e-01	0.247	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	5.658427e-01	0.247	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.658427e-01	0.247	0	0
Physiological factors	R-HSA-5578768	5.658427e-01	0.247	0	0
Regulation of KIT signaling	R-HSA-1433559	5.658427e-01	0.247	0	0
Non-canonical inflammasome activation	R-HSA-9686114	5.658427e-01	0.247	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	5.658427e-01	0.247	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	5.664057e-01	0.247	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.664057e-01	0.247	0	0
Nuclear import of Rev protein	R-HSA-180746	5.664057e-01	0.247	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	5.691216e-01	0.245	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	5.693388e-01	0.245	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	5.693388e-01	0.245	0	0
Sensory processing of sound	R-HSA-9659379	5.729932e-01	0.242	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	5.794474e-01	0.237	0	0
Signalling to ERKs	R-HSA-187687	5.794474e-01	0.237	0	0
Signaling by FGFR2	R-HSA-5654738	5.819450e-01	0.235	0	0
Glycolysis	R-HSA-70171	5.847789e-01	0.233	0	0
Erythropoietin activates RAS	R-HSA-9027284	5.855191e-01	0.232	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	5.855191e-01	0.232	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	5.855191e-01	0.232	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.855191e-01	0.232	0	0
Signaling by Activin	R-HSA-1502540	5.855191e-01	0.232	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	5.855191e-01	0.232	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.855191e-01	0.232	0	0
Spry regulation of FGF signaling	R-HSA-1295596	5.855191e-01	0.232	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	5.900600e-01	0.229	0	0
HSF1 activation	R-HSA-3371511	5.921988e-01	0.228	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	5.921988e-01	0.228	0	0
Calmodulin induced events	R-HSA-111933	5.921988e-01	0.228	0	0
CaM pathway	R-HSA-111997	5.921988e-01	0.228	0	0
GPVI-mediated activation cascade	R-HSA-114604	5.921988e-01	0.228	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	5.921988e-01	0.228	0	0
Phospholipid metabolism	R-HSA-1483257	5.984375e-01	0.223	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	6.004430e-01	0.222	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.043049e-01	0.219	0	0
Killing mechanisms	R-HSA-9664420	6.043049e-01	0.219	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.043049e-01	0.219	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	6.043049e-01	0.219	0	0
Differentiation of T cells	R-HSA-9945266	6.043049e-01	0.219	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.043049e-01	0.219	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.043049e-01	0.219	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	6.046594e-01	0.218	0	0
MHC class II antigen presentation	R-HSA-2132295	6.091620e-01	0.215	0	0
GABA receptor activation	R-HSA-977443	6.101278e-01	0.215	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	6.101278e-01	0.215	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	6.101278e-01	0.215	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	6.101278e-01	0.215	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	6.101278e-01	0.215	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	6.101278e-01	0.215	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	6.101278e-01	0.215	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	6.107301e-01	0.214	0	0
MET promotes cell motility	R-HSA-8875878	6.168294e-01	0.210	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	6.168294e-01	0.210	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	6.199121e-01	0.208	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.222403e-01	0.206	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.222403e-01	0.206	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.222403e-01	0.206	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	6.222403e-01	0.206	0	0
Disorders of Developmental Biology	R-HSA-9675151	6.222403e-01	0.206	0	0
Coenzyme A biosynthesis	R-HSA-196783	6.222403e-01	0.206	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	6.222403e-01	0.206	0	0
SLC transporter disorders	R-HSA-5619102	6.246242e-01	0.204	0	0
Stabilization of p53	R-HSA-69541	6.287095e-01	0.202	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	6.287095e-01	0.202	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	6.389746e-01	0.195	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	6.389746e-01	0.195	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	6.393639e-01	0.194	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	6.393639e-01	0.194	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.393639e-01	0.194	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.393639e-01	0.194	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.393639e-01	0.194	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	6.393639e-01	0.194	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.393639e-01	0.194	0	0
Choline catabolism	R-HSA-6798163	6.393639e-01	0.194	0	0
Attenuation phase	R-HSA-3371568	6.403011e-01	0.194	0	0
Generation of second messenger molecules	R-HSA-202433	6.403011e-01	0.194	0	0
Interleukin-2 family signaling	R-HSA-451927	6.403011e-01	0.194	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	6.403011e-01	0.194	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	6.403011e-01	0.194	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	6.423580e-01	0.192	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	6.516057e-01	0.186	0	0
Gastrulation	R-HSA-9758941	6.545827e-01	0.184	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	6.557122e-01	0.183	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.557122e-01	0.183	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.557122e-01	0.183	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	6.557122e-01	0.183	0	0
Mismatch Repair	R-HSA-5358508	6.557122e-01	0.183	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	6.557122e-01	0.183	0	0
Platelet sensitization by LDL	R-HSA-432142	6.557122e-01	0.183	0	0
Tie2 Signaling	R-HSA-210993	6.557122e-01	0.183	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.557122e-01	0.183	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	6.574025e-01	0.182	0	0
Selective autophagy	R-HSA-9663891	6.574025e-01	0.182	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.626257e-01	0.179	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	6.626257e-01	0.179	0	0
Signaling by Interleukins	R-HSA-449147	6.663105e-01	0.176	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	6.705454e-01	0.174	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	6.713204e-01	0.173	0	0
Pyrimidine biosynthesis	R-HSA-500753	6.713204e-01	0.173	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	6.713204e-01	0.173	0	0
The NLRP3 inflammasome	R-HSA-844456	6.713204e-01	0.173	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.713204e-01	0.173	0	0
Maturation of nucleoprotein	R-HSA-9694631	6.713204e-01	0.173	0	0
Ca-dependent events	R-HSA-111996	6.733636e-01	0.172	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	6.733636e-01	0.172	0	0
Vesicle-mediated transport	R-HSA-5653656	6.779621e-01	0.169	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	6.804119e-01	0.167	0	0
Transcription of the HIV genome	R-HSA-167172	6.836485e-01	0.165	0	0
Regulated Necrosis	R-HSA-5218859	6.836485e-01	0.165	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	6.836485e-01	0.165	0	0
Signaling by FGFR4	R-HSA-5654743	6.838223e-01	0.165	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	6.862219e-01	0.164	0	0
Co-inhibition by CTLA4	R-HSA-389513	6.862219e-01	0.164	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	6.862219e-01	0.164	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.862219e-01	0.164	0	0
Signaling by NODAL	R-HSA-1181150	6.862219e-01	0.164	0	0
Nephrin family interactions	R-HSA-373753	6.862219e-01	0.164	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	6.862219e-01	0.164	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	6.940050e-01	0.159	0	0
RMTs methylate histone arginines	R-HSA-3214858	6.940050e-01	0.159	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.004487e-01	0.155	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	7.004487e-01	0.155	0	0
ERK/MAPK targets	R-HSA-198753	7.004487e-01	0.155	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.004487e-01	0.155	0	0
HIV Life Cycle	R-HSA-162587	7.009097e-01	0.154	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.039153e-01	0.152	0	0
Signaling by FGFR3	R-HSA-5654741	7.039153e-01	0.152	0	0
Fanconi Anemia Pathway	R-HSA-6783310	7.039153e-01	0.152	0	0
DAG and IP3 signaling	R-HSA-1489509	7.039153e-01	0.152	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.039153e-01	0.152	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.039153e-01	0.152	0	0
HIV Infection	R-HSA-162906	7.074231e-01	0.150	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.135570e-01	0.147	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.135570e-01	0.147	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	7.135570e-01	0.147	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.135570e-01	0.147	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.135570e-01	0.147	0	0
Signaling by TGFBR3	R-HSA-9839373	7.135570e-01	0.147	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.140312e-01	0.146	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.140312e-01	0.146	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.140312e-01	0.146	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	7.140312e-01	0.146	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.140312e-01	0.146	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	7.140312e-01	0.146	0	0
Signaling by PDGFR in disease	R-HSA-9671555	7.140312e-01	0.146	0	0
L1CAM interactions	R-HSA-373760	7.190302e-01	0.143	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	7.229339e-01	0.141	0	0
Recycling pathway of L1	R-HSA-437239	7.229339e-01	0.141	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.229339e-01	0.141	0	0
Glucose metabolism	R-HSA-70326	7.251529e-01	0.140	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	7.269987e-01	0.138	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.269987e-01	0.138	0	0
Notch-HLH transcription pathway	R-HSA-350054	7.269987e-01	0.138	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.269987e-01	0.138	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	7.269987e-01	0.138	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.269987e-01	0.138	0	0
Potassium Channels	R-HSA-1296071	7.298123e-01	0.137	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.393789e-01	0.131	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.393789e-01	0.131	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.393789e-01	0.131	0	0
Carnitine shuttle	R-HSA-200425	7.393789e-01	0.131	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.393789e-01	0.131	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	7.393789e-01	0.131	0	0
Syndecan interactions	R-HSA-3000170	7.393789e-01	0.131	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.395668e-01	0.131	0	0
Signaling by FGFR	R-HSA-190236	7.428276e-01	0.129	0	0
Signaling by NOTCH1	R-HSA-1980143	7.463201e-01	0.127	0	0
Regulation of RAS by GAPs	R-HSA-5658442	7.495190e-01	0.125	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	7.511984e-01	0.124	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.511984e-01	0.124	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	7.511984e-01	0.124	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	7.511984e-01	0.124	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	7.511984e-01	0.124	0	0
Neurodegenerative Diseases	R-HSA-8863678	7.511984e-01	0.124	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	7.511984e-01	0.124	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	7.624825e-01	0.118	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.624825e-01	0.118	0	0
Long-term potentiation	R-HSA-9620244	7.624825e-01	0.118	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	7.624825e-01	0.118	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	7.624825e-01	0.118	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	7.624825e-01	0.118	0	0
Host Interactions of HIV factors	R-HSA-162909	7.653256e-01	0.116	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.659993e-01	0.116	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	7.671148e-01	0.115	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	7.694375e-01	0.114	0	0
Metalloprotease DUBs	R-HSA-5689901	7.732555e-01	0.112	0	0
Myogenesis	R-HSA-525793	7.732555e-01	0.112	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	7.732555e-01	0.112	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	7.732555e-01	0.112	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.738806e-01	0.111	0	0
Opioid Signalling	R-HSA-111885	7.790060e-01	0.108	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	7.815291e-01	0.107	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	7.815291e-01	0.107	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	7.835406e-01	0.106	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	7.835406e-01	0.106	0	0
Triglyceride biosynthesis	R-HSA-75109	7.835406e-01	0.106	0	0
Synthesis of PE	R-HSA-1483213	7.835406e-01	0.106	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	7.835406e-01	0.106	0	0
Signaling by BMP	R-HSA-201451	7.835406e-01	0.106	0	0
Insulin processing	R-HSA-264876	7.835406e-01	0.106	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	7.835406e-01	0.106	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.889497e-01	0.103	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	7.933596e-01	0.101	0	0
Inflammasomes	R-HSA-622312	7.933596e-01	0.101	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.961473e-01	0.099	0	0
Signaling by FGFR1	R-HSA-5654736	7.961473e-01	0.099	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.961473e-01	0.099	0	0
Metabolism of amine-derived hormones	R-HSA-209776	7.961473e-01	0.099	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	7.985586e-01	0.098	0	0
Interleukin-1 family signaling	R-HSA-446652	7.985586e-01	0.098	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	8.008059e-01	0.096	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	8.027339e-01	0.095	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	8.027339e-01	0.095	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.027339e-01	0.095	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	8.027339e-01	0.095	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.027339e-01	0.095	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	8.027339e-01	0.095	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	8.027339e-01	0.095	0	0
Synthesis of PA	R-HSA-1483166	8.031269e-01	0.095	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	8.045295e-01	0.094	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	8.059758e-01	0.094	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	8.059758e-01	0.094	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	8.059758e-01	0.094	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	8.073099e-01	0.093	0	0
Neuronal System	R-HSA-112316	8.105574e-01	0.091	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	8.116834e-01	0.091	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	8.116834e-01	0.091	0	0
DAP12 signaling	R-HSA-2424491	8.116834e-01	0.091	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.116834e-01	0.091	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.158246e-01	0.088	0	0
Triglyceride metabolism	R-HSA-8979227	8.164517e-01	0.088	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	8.164517e-01	0.088	0	0
Regulation of beta-cell development	R-HSA-186712	8.164517e-01	0.088	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.202274e-01	0.086	0	0
Cargo concentration in the ER	R-HSA-5694530	8.202274e-01	0.086	0	0
Downstream signal transduction	R-HSA-186763	8.202274e-01	0.086	0	0
Post NMDA receptor activation events	R-HSA-438064	8.212615e-01	0.086	0	0
Cellular response to starvation	R-HSA-9711097	8.239202e-01	0.084	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	8.255727e-01	0.083	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	8.255727e-01	0.083	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	8.283843e-01	0.082	0	0
PLC beta mediated events	R-HSA-112043	8.289639e-01	0.081	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.289639e-01	0.081	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.349275e-01	0.078	0	0
tRNA processing in the nucleus	R-HSA-6784531	8.349275e-01	0.078	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.349275e-01	0.078	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	8.361716e-01	0.078	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.361716e-01	0.078	0	0
G-protein beta:gamma signalling	R-HSA-397795	8.361716e-01	0.078	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	8.361716e-01	0.078	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	8.361783e-01	0.078	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	8.407026e-01	0.075	0	0
Signaling by PTK6	R-HSA-8848021	8.407026e-01	0.075	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.407026e-01	0.075	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.416809e-01	0.075	0	0
Metabolism of RNA	R-HSA-8953854	8.427255e-01	0.074	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	8.436059e-01	0.074	0	0
Miscellaneous transport and binding events	R-HSA-5223345	8.436059e-01	0.074	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.436059e-01	0.074	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	8.462941e-01	0.072	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	8.464334e-01	0.072	0	0
PTEN Regulation	R-HSA-6807070	8.480213e-01	0.072	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.507033e-01	0.070	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	8.507033e-01	0.070	0	0
Signal amplification	R-HSA-392518	8.507033e-01	0.070	0	0
Mitophagy	R-HSA-5205647	8.507033e-01	0.070	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.507033e-01	0.070	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	8.507033e-01	0.070	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	8.517066e-01	0.070	0	0
Eukaryotic Translation Initiation	R-HSA-72613	8.518700e-01	0.070	0	0
Cap-dependent Translation Initiation	R-HSA-72737	8.518700e-01	0.070	0	0
Mitochondrial biogenesis	R-HSA-1592230	8.559099e-01	0.068	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	8.574790e-01	0.067	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	8.574790e-01	0.067	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.574790e-01	0.067	0	0
Oncogene Induced Senescence	R-HSA-2559585	8.574790e-01	0.067	0	0
Collagen formation	R-HSA-1474290	8.600121e-01	0.065	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	8.620137e-01	0.064	0	0
G-protein mediated events	R-HSA-112040	8.620137e-01	0.064	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	8.637090e-01	0.064	0	0
Triglyceride catabolism	R-HSA-163560	8.639477e-01	0.064	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	8.669176e-01	0.062	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	8.669176e-01	0.062	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	8.684693e-01	0.061	0	0
Neddylation	R-HSA-8951664	8.690353e-01	0.061	0	0
Disorders of transmembrane transporters	R-HSA-5619115	8.698110e-01	0.061	0	0
Voltage gated Potassium channels	R-HSA-1296072	8.701231e-01	0.060	0	0
Degradation of DVL	R-HSA-4641258	8.701231e-01	0.060	0	0
Ovarian tumor domain proteases	R-HSA-5689896	8.701231e-01	0.060	0	0
Lysine catabolism	R-HSA-71064	8.701231e-01	0.060	0	0
Collagen chain trimerization	R-HSA-8948216	8.701231e-01	0.060	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	8.725266e-01	0.059	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	8.736500e-01	0.059	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	8.762484e-01	0.057	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.806842e-01	0.055	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	8.806842e-01	0.055	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.816467e-01	0.055	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	8.858483e-01	0.053	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	8.863150e-01	0.052	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	8.870197e-01	0.052	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	8.870197e-01	0.052	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.870197e-01	0.052	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.870197e-01	0.052	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	8.870197e-01	0.052	0	0
Tryptophan catabolism	R-HSA-71240	8.870197e-01	0.052	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	8.870197e-01	0.052	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	8.875416e-01	0.052	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.884677e-01	0.051	0	0
Maturation of spike protein	R-HSA-9694548	8.921491e-01	0.050	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.921491e-01	0.050	0	0
Neutrophil degranulation	R-HSA-6798695	8.921848e-01	0.050	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.942661e-01	0.049	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	8.946199e-01	0.048	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.969963e-01	0.047	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.969963e-01	0.047	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.970460e-01	0.047	0	0
HIV Transcription Initiation	R-HSA-167161	8.970460e-01	0.047	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.970460e-01	0.047	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.970460e-01	0.047	0	0
Intra-Golgi traffic	R-HSA-6811438	8.970460e-01	0.047	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.970460e-01	0.047	0	0
Translation of Structural Proteins	R-HSA-9683701	8.970460e-01	0.047	0	0
Interleukin-12 signaling	R-HSA-9020591	9.007370e-01	0.045	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	9.024247e-01	0.045	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.043239e-01	0.044	0	0
Translation of Structural Proteins	R-HSA-9694635	9.043507e-01	0.044	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	9.061835e-01	0.043	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.061835e-01	0.043	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.061835e-01	0.043	0	0
Developmental Cell Lineages	R-HSA-9734767	9.071623e-01	0.042	0	0
PCP/CE pathway	R-HSA-4086400	9.078413e-01	0.042	0	0
Interleukin-10 signaling	R-HSA-6783783	9.078413e-01	0.042	0	0
Platelet homeostasis	R-HSA-418346	9.103371e-01	0.041	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	9.103371e-01	0.041	0	0
DAP12 interactions	R-HSA-2172127	9.104439e-01	0.041	0	0
Amine ligand-binding receptors	R-HSA-375280	9.104439e-01	0.041	0	0
Interferon gamma signaling	R-HSA-877300	9.124477e-01	0.040	0	0
Signaling by MET	R-HSA-6806834	9.144677e-01	0.039	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.144677e-01	0.039	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.145111e-01	0.039	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.145111e-01	0.039	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	9.145111e-01	0.039	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.145111e-01	0.039	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.176107e-01	0.037	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.183938e-01	0.037	0	0
Cilium Assembly	R-HSA-5617833	9.212447e-01	0.036	0	0
TCR signaling	R-HSA-202403	9.213455e-01	0.036	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.221003e-01	0.035	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.221003e-01	0.035	0	0
Synthesis of PC	R-HSA-1483191	9.221003e-01	0.035	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.235738e-01	0.035	0	0
Integration of energy metabolism	R-HSA-163685	9.236714e-01	0.034	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.256388e-01	0.034	0	0
Metal ion SLC transporters	R-HSA-425410	9.256388e-01	0.034	0	0
Degradation of CDH1	R-HSA-9766229	9.290167e-01	0.032	0	0
Gap junction trafficking and regulation	R-HSA-157858	9.290167e-01	0.032	0	0
DNA Damage Bypass	R-HSA-73893	9.290167e-01	0.032	0	0
Parasite infection	R-HSA-9664407	9.323428e-01	0.030	0	0
Leishmania phagocytosis	R-HSA-9664417	9.323428e-01	0.030	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.323428e-01	0.030	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.343003e-01	0.030	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	9.353197e-01	0.029	0	0
Complex IV assembly	R-HSA-9864848	9.353197e-01	0.029	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.353197e-01	0.029	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.353197e-01	0.029	0	0
The phototransduction cascade	R-HSA-2514856	9.353197e-01	0.029	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.355563e-01	0.029	0	0
Interleukin-12 family signaling	R-HSA-447115	9.367501e-01	0.028	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.376808e-01	0.028	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.382508e-01	0.028	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.382584e-01	0.028	0	0
Peptide chain elongation	R-HSA-156902	9.391132e-01	0.027	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.410638e-01	0.026	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	9.410638e-01	0.026	0	0
SARS-CoV-1 Infection	R-HSA-9678108	9.456302e-01	0.024	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.457097e-01	0.024	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.462983e-01	0.024	0	0
G alpha (z) signalling events	R-HSA-418597	9.462983e-01	0.024	0	0
Signaling by EGFR	R-HSA-177929	9.487388e-01	0.023	0	0
Eukaryotic Translation Elongation	R-HSA-156842	9.497232e-01	0.022	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.497232e-01	0.022	0	0
Immune System	R-HSA-168256	9.507590e-01	0.022	0	0
Regulation of CDH1 Function	R-HSA-9764561	9.510685e-01	0.022	0	0
Influenza Infection	R-HSA-168255	9.515642e-01	0.022	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.516223e-01	0.022	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	9.527907e-01	0.021	0	0
SARS-CoV Infections	R-HSA-9679506	9.527988e-01	0.021	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.532925e-01	0.021	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.532925e-01	0.021	0	0
SARS-CoV-2 Infection	R-HSA-9694516	9.548053e-01	0.020	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.552169e-01	0.020	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.554155e-01	0.020	0	0
Viral Infection Pathways	R-HSA-9824446	9.557369e-01	0.020	0	0
Transmission across Chemical Synapses	R-HSA-112315	9.559409e-01	0.020	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.569170e-01	0.019	0	0
Eukaryotic Translation Termination	R-HSA-72764	9.569170e-01	0.019	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.574421e-01	0.019	0	0
tRNA Aminoacylation	R-HSA-379724	9.574421e-01	0.019	0	0
Aquaporin-mediated transport	R-HSA-445717	9.593768e-01	0.018	0	0
MAP kinase activation	R-HSA-450294	9.593768e-01	0.018	0	0
Collagen degradation	R-HSA-1442490	9.593768e-01	0.018	0	0
Mitochondrial protein import	R-HSA-1268020	9.612236e-01	0.017	0	0
Signaling by PDGF	R-HSA-186797	9.612236e-01	0.017	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.628212e-01	0.016	0	0
Selenocysteine synthesis	R-HSA-2408557	9.658899e-01	0.015	0	0
Viral mRNA Translation	R-HSA-192823	9.684597e-01	0.014	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.686548e-01	0.014	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.696736e-01	0.013	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	9.696736e-01	0.013	0	0
Hemostasis	R-HSA-109582	9.700410e-01	0.013	0	0
Interleukin-17 signaling	R-HSA-448424	9.732780e-01	0.012	0	0
Retinoid metabolism and transport	R-HSA-975634	9.744935e-01	0.011	0	0
Metabolism of cofactors	R-HSA-8978934	9.744935e-01	0.011	0	0
Ribosome-associated quality control	R-HSA-9948299	9.746375e-01	0.011	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.753914e-01	0.011	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	9.756538e-01	0.011	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.756538e-01	0.011	0	0
rRNA processing	R-HSA-72312	9.758924e-01	0.011	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	9.761854e-01	0.010	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.763801e-01	0.010	0	0
G alpha (q) signalling events	R-HSA-416476	9.772654e-01	0.010	0	0
Post-translational protein modification	R-HSA-597592	9.775616e-01	0.010	0	0
Signaling by NOTCH4	R-HSA-9013694	9.778186e-01	0.010	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.788278e-01	0.009	0	0
Interferon Signaling	R-HSA-913531	9.799750e-01	0.009	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.802477e-01	0.009	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	9.803768e-01	0.009	0	0
ABC transporter disorders	R-HSA-5619084	9.815885e-01	0.008	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.815885e-01	0.008	0	0
Integrin cell surface interactions	R-HSA-216083	9.815885e-01	0.008	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.824264e-01	0.008	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.825920e-01	0.008	0	0
Peptide hormone metabolism	R-HSA-2980736	9.839319e-01	0.007	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.839896e-01	0.007	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.846620e-01	0.007	0	0
Leishmania infection	R-HSA-9658195	9.859414e-01	0.006	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.859414e-01	0.006	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.873168e-01	0.006	0	0
Pyruvate metabolism	R-HSA-70268	9.884455e-01	0.005	0	0
Chaperonin-mediated protein folding	R-HSA-390466	9.884455e-01	0.005	0	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.889716e-01	0.005	0	0
ER-Phagosome pathway	R-HSA-1236974	9.894739e-01	0.005	0	0
Platelet degranulation	R-HSA-114608	9.896894e-01	0.005	0	0
Downstream TCR signaling	R-HSA-202424	9.899533e-01	0.004	0	0
Neurotransmitter release cycle	R-HSA-112310	9.899533e-01	0.004	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.912645e-01	0.004	0	0
Protein folding	R-HSA-391251	9.912645e-01	0.004	0	0
GPCR downstream signalling	R-HSA-388396	9.913180e-01	0.004	0	0
Adipogenesis	R-HSA-9843745	9.915863e-01	0.004	0	0
Disease	R-HSA-1643685	9.922914e-01	0.003	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.924048e-01	0.003	0	0
G alpha (s) signalling events	R-HSA-418555	9.929307e-01	0.003	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.930812e-01	0.003	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.930812e-01	0.003	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.933387e-01	0.003	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.936806e-01	0.003	0	0
Regulation of insulin secretion	R-HSA-422356	9.936974e-01	0.003	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	9.936974e-01	0.003	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	9.936974e-01	0.003	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	9.936974e-01	0.003	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.942587e-01	0.003	0	0
RSV-host interactions	R-HSA-9833110	9.954533e-01	0.002	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	9.956606e-01	0.002	0	0
Visual phototransduction	R-HSA-2187338	9.959836e-01	0.002	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.962275e-01	0.002	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.962275e-01	0.002	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.963996e-01	0.002	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	9.965638e-01	0.001	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	9.965638e-01	0.001	0	0
Protein localization	R-HSA-9609507	9.968685e-01	0.001	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.968701e-01	0.001	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.970129e-01	0.001	0	0
PPARA activates gene expression	R-HSA-1989781	9.971185e-01	0.001	0	0
Cellular response to chemical stress	R-HSA-9711123	9.972529e-01	0.001	0	0
Signaling by GPCR	R-HSA-372790	9.972863e-01	0.001	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.973489e-01	0.001	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	9.974033e-01	0.001	0	0
Sphingolipid metabolism	R-HSA-428157	9.977418e-01	0.001	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	9.979441e-01	0.001	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	9.979441e-01	0.001	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.980212e-01	0.001	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.981275e-01	0.001	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.981275e-01	0.001	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	9.982130e-01	0.001	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	9.982130e-01	0.001	0	0
Formation of the cornified envelope	R-HSA-6809371	9.983724e-01	0.001	0	0
tRNA processing	R-HSA-72306	9.985250e-01	0.001	0	0
Sensory perception of taste	R-HSA-9717189	9.989313e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.989489e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.989801e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.992222e-01	0.000	0	0
Signaling by Hedgehog	R-HSA-5358351	9.992648e-01	0.000	0	0
Toll-like Receptor Cascades	R-HSA-168898	9.993935e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.994130e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.994715e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.995195e-01	0.000	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.995606e-01	0.000	0	0
Translation	R-HSA-72766	9.996172e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.998869e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.998912e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.998972e-01	0.000	0	0
Infectious disease	R-HSA-5663205	9.999150e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999161e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999294e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999736e-01	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	9.999820e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999849e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999911e-01	0.000	0	0
Metabolism of proteins	R-HSA-392499	9.999924e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999926e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.999939e-01	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999948e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999975e-01	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	9.999991e-01	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	9.999999e-01	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cell Cycle, Mitotic	R-HSA-69278	1.110223e-16	15.955	0	0
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955	0	0
Axon guidance	R-HSA-422475	1.110223e-16	15.955	0	0
Nervous system development	R-HSA-9675108	1.110223e-16	15.955	0	0
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955	0	0
Cellular responses to stress	R-HSA-2262752	4.440892e-16	15.353	0	0
M Phase	R-HSA-68886	1.554312e-15	14.808	0	0
Cell-Cell communication	R-HSA-1500931	1.078027e-13	12.967	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.176370e-12	11.662	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	8.530843e-12	11.069	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	8.530843e-12	11.069	0	0
Signaling by ROBO receptors	R-HSA-376176	9.163670e-12	11.038	0	0
Cell junction organization	R-HSA-446728	1.045408e-11	10.981	0	0
HSF1-dependent transactivation	R-HSA-3371571	5.920908e-11	10.228	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	7.209544e-11	10.142	0	0
EPH-Ephrin signaling	R-HSA-2682334	9.434542e-11	10.025	0	0
Metabolism of RNA	R-HSA-8953854	9.925327e-11	10.003	0	0
Eukaryotic Translation Initiation	R-HSA-72613	1.323625e-10	9.878	0	0
Cap-dependent Translation Initiation	R-HSA-72737	1.323625e-10	9.878	0	0
Apoptosis	R-HSA-109581	1.641023e-10	9.785	1	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.833720e-10	9.737	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.125309e-10	9.673	0	0
Attenuation phase	R-HSA-3371568	3.202916e-10	9.494	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	4.231671e-10	9.373	0	0
Cell Cycle Checkpoints	R-HSA-69620	4.085479e-10	9.389	0	0
Adherens junctions interactions	R-HSA-418990	4.935345e-10	9.307	0	0
Eukaryotic Translation Elongation	R-HSA-156842	9.015702e-10	9.045	0	0
G2/M Checkpoints	R-HSA-69481	9.896449e-10	9.005	0	0
Programmed Cell Death	R-HSA-5357801	1.228365e-09	8.911	1	0
Cell-cell junction organization	R-HSA-421270	1.285698e-09	8.891	0	0
Cellular response to heat stress	R-HSA-3371556	1.314525e-09	8.881	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.668246e-09	8.778	0	0
Apoptotic execution phase	R-HSA-75153	1.755237e-09	8.756	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	2.086760e-09	8.681	0	0
ESR-mediated signaling	R-HSA-8939211	2.731933e-09	8.564	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.568858e-09	8.447	0	0
Assembly of the pre-replicative complex	R-HSA-68867	3.561698e-09	8.448	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	4.577843e-09	8.339	0	0
Estrogen-dependent gene expression	R-HSA-9018519	4.703504e-09	8.328	0	0
Developmental Biology	R-HSA-1266738	5.599821e-09	8.252	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	5.997345e-09	8.222	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.961062e-09	8.225	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	6.465019e-09	8.189	0	0
Signal Transduction	R-HSA-162582	7.002205e-09	8.155	0	0
Ribosome-associated quality control	R-HSA-9948299	7.241753e-09	8.140	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	8.019796e-09	8.096	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.282402e-08	7.892	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.282402e-08	7.892	0	0
HSF1 activation	R-HSA-3371511	1.609650e-08	7.793	0	0
Peptide chain elongation	R-HSA-156902	1.697697e-08	7.770	0	0
DNA Replication Pre-Initiation	R-HSA-69002	1.669618e-08	7.777	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.744610e-08	7.758	0	0
G2/M Transition	R-HSA-69275	2.234653e-08	7.651	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	2.503043e-08	7.602	0	0
Meiotic synapsis	R-HSA-1221632	2.552190e-08	7.593	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	2.758871e-08	7.559	0	0
Mitotic G2-G2/M phases	R-HSA-453274	3.164898e-08	7.500	0	0
Translation initiation complex formation	R-HSA-72649	3.614352e-08	7.442	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	4.144372e-08	7.383	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.634044e-08	7.334	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	5.022971e-08	7.299	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	5.751600e-08	7.240	0	0
Striated Muscle Contraction	R-HSA-390522	7.171034e-08	7.144	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	7.083378e-08	7.150	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	6.916794e-08	7.160	0	0
Signaling by VEGF	R-HSA-194138	6.957774e-08	7.158	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	7.319406e-08	7.136	0	0
Mitotic Prometaphase	R-HSA-68877	7.359622e-08	7.133	0	0
Signaling by RAS mutants	R-HSA-6802949	8.979927e-08	7.047	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	8.979927e-08	7.047	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	8.979927e-08	7.047	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	8.979927e-08	7.047	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	1.044561e-07	6.981	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.216563e-07	6.915	0	0
DNA methylation	R-HSA-5334118	1.310744e-07	6.882	0	0
Mitotic Anaphase	R-HSA-68882	1.670365e-07	6.777	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	1.842932e-07	6.734	0	0
Cellular Senescence	R-HSA-2559583	1.840555e-07	6.735	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.941149e-07	6.712	0	0
Separation of Sister Chromatids	R-HSA-2467813	2.345612e-07	6.630	0	0
PRC2 methylates histones and DNA	R-HSA-212300	2.496611e-07	6.603	0	0
Mitotic Prophase	R-HSA-68875	2.921246e-07	6.534	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	3.138276e-07	6.503	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.189525e-07	6.496	0	0
Meiosis	R-HSA-1500620	3.751477e-07	6.426	0	0
Diseases of programmed cell death	R-HSA-9645723	3.681799e-07	6.434	0	0
Defective pyroptosis	R-HSA-9710421	3.768262e-07	6.424	0	0
Muscle contraction	R-HSA-397014	3.825181e-07	6.417	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	4.464322e-07	6.350	0	0
Membrane Trafficking	R-HSA-199991	5.416202e-07	6.266	0	0
Signaling by RAF1 mutants	R-HSA-9656223	6.465250e-07	6.189	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	6.696519e-07	6.174	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	7.320987e-07	6.135	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	7.638087e-07	6.117	0	0
Signaling by ERBB2	R-HSA-1227986	7.638087e-07	6.117	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	8.039790e-07	6.095	0	0
Packaging Of Telomere Ends	R-HSA-171306	9.253161e-07	6.034	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	9.104354e-07	6.041	0	0
Regulation of CDH1 Function	R-HSA-9764561	9.702473e-07	6.013	0	0
mRNA Splicing	R-HSA-72172	9.764004e-07	6.010	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.044030e-06	5.981	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.109902e-06	5.955	0	0
Eukaryotic Translation Termination	R-HSA-72764	1.115201e-06	5.953	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.339709e-06	5.873	0	0
G2/M DNA damage checkpoint	R-HSA-69473	1.367522e-06	5.864	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.389990e-06	5.857	0	0
Recycling pathway of L1	R-HSA-437239	1.428312e-06	5.845	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.568558e-06	5.804	0	0
HDACs deacetylate histones	R-HSA-3214815	1.647200e-06	5.783	0	0
Signaling by WNT	R-HSA-195721	1.747368e-06	5.758	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.099522e-06	5.678	0	0
Interleukin-12 signaling	R-HSA-9020591	2.236242e-06	5.650	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.279192e-06	5.642	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.442408e-06	5.612	0	0
Nucleosome assembly	R-HSA-774815	2.442408e-06	5.612	0	0
Oncogenic MAPK signaling	R-HSA-6802957	2.636496e-06	5.579	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.828556e-06	5.548	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.913689e-06	5.536	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.962182e-06	5.528	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.330655e-06	5.477	0	0
DNA Replication	R-HSA-69306	3.766091e-06	5.424	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	3.845546e-06	5.415	0	0
Selenocysteine synthesis	R-HSA-2408557	3.896929e-06	5.409	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.354228e-06	5.361	0	0
Regulation of signaling by CBL	R-HSA-912631	4.791369e-06	5.320	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	4.837405e-06	5.315	0	0
Interleukin-12 family signaling	R-HSA-447115	5.101790e-06	5.292	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	5.213432e-06	5.283	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	5.639356e-06	5.249	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	5.639356e-06	5.249	0	0
Viral mRNA Translation	R-HSA-192823	5.769560e-06	5.239	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	6.310497e-06	5.200	0	0
Influenza Infection	R-HSA-168255	5.989617e-06	5.223	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	6.415332e-06	5.193	0	0
Signaling by ALK in cancer	R-HSA-9700206	6.415332e-06	5.193	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	6.700132e-06	5.174	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	6.799093e-06	5.168	0	0
MAPK family signaling cascades	R-HSA-5683057	6.876064e-06	5.163	0	0
Chromatin organization	R-HSA-4839726	7.229546e-06	5.141	0	0
Chromatin modifying enzymes	R-HSA-3247509	7.380098e-06	5.132	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	8.224369e-06	5.085	0	0
Smooth Muscle Contraction	R-HSA-445355	8.277511e-06	5.082	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	8.805397e-06	5.055	0	0
RNA Polymerase I Transcription	R-HSA-73864	9.293175e-06	5.032	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	9.867455e-06	5.006	0	0
Ub-specific processing proteases	R-HSA-5689880	1.010843e-05	4.995	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	1.044552e-05	4.981	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.071503e-05	4.970	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.214035e-05	4.916	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.214035e-05	4.916	0	0
Post NMDA receptor activation events	R-HSA-438064	1.257281e-05	4.901	0	0
Ephrin signaling	R-HSA-3928664	1.308414e-05	4.883	0	0
SARS-CoV-1 Infection	R-HSA-9678108	1.334627e-05	4.875	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	1.365734e-05	4.865	0	0
Signaling by PTK6	R-HSA-8848021	1.367987e-05	4.864	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.367987e-05	4.864	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.395090e-05	4.855	0	0
Meiotic recombination	R-HSA-912446	1.397235e-05	4.855	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.520277e-05	4.818	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.533761e-05	4.814	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	1.595369e-05	4.797	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	1.601227e-05	4.796	0	0
EPHB-mediated forward signaling	R-HSA-3928662	1.748000e-05	4.757	0	0
Kinesins	R-HSA-983189	1.785432e-05	4.748	0	0
RAF activation	R-HSA-5673000	1.910074e-05	4.719	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.066125e-05	4.685	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	2.379405e-05	4.624	0	0
Regulation of endogenous retroelements	R-HSA-9842860	2.535355e-05	4.596	0	0
AURKA Activation by TPX2	R-HSA-8854518	2.759074e-05	4.559	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.889518e-05	4.539	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	3.287192e-05	4.483	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.621755e-05	4.441	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.621755e-05	4.441	0	0
Intracellular signaling by second messengers	R-HSA-9006925	3.342978e-05	4.476	0	0
Signaling by Hippo	R-HSA-2028269	3.544723e-05	4.450	0	0
DNA Double Strand Break Response	R-HSA-5693606	3.451451e-05	4.462	0	0
RAF/MAP kinase cascade	R-HSA-5673001	3.408859e-05	4.467	0	0
rRNA processing	R-HSA-72312	3.516707e-05	4.454	0	0
UCH proteinases	R-HSA-5689603	3.781821e-05	4.422	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	4.071538e-05	4.390	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.204396e-05	4.376	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	4.297107e-05	4.367	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	4.299453e-05	4.367	0	0
L1CAM interactions	R-HSA-373760	4.324571e-05	4.364	0	0
Viral Infection Pathways	R-HSA-9824446	4.582854e-05	4.339	0	0
Signaling by NOTCH	R-HSA-157118	4.816781e-05	4.317	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.848949e-05	4.314	0	0
Cleavage of the damaged purine	R-HSA-110331	4.848949e-05	4.314	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.983762e-05	4.302	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	5.021619e-05	4.299	0	0
RMTs methylate histone arginines	R-HSA-3214858	5.146978e-05	4.288	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	5.148523e-05	4.288	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	5.525835e-05	4.258	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	6.371114e-05	4.196	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	6.073523e-05	4.217	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	6.048812e-05	4.218	0	0
Depurination	R-HSA-73927	6.483099e-05	4.188	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	7.096450e-05	4.149	0	0
HATs acetylate histones	R-HSA-3214847	7.407390e-05	4.130	0	0
Centrosome maturation	R-HSA-380287	7.478922e-05	4.126	0	0
Deubiquitination	R-HSA-5688426	7.796907e-05	4.108	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	8.069623e-05	4.093	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	8.694366e-05	4.061	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	8.694366e-05	4.061	0	0
Depyrimidination	R-HSA-73928	8.694366e-05	4.061	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	9.766230e-05	4.010	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.064840e-04	3.973	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.105395e-04	3.956	0	0
Aggrephagy	R-HSA-9646399	1.127473e-04	3.948	0	0
Reproduction	R-HSA-1474165	1.138632e-04	3.944	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	1.198144e-04	3.921	0	0
Cellular response to starvation	R-HSA-9711097	1.199560e-04	3.921	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	1.216170e-04	3.915	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.217900e-04	3.914	0	0
Nephrin family interactions	R-HSA-373753	1.250336e-04	3.903	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	1.318590e-04	3.880	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.338939e-04	3.873	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	1.510926e-04	3.821	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	1.639216e-04	3.785	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.755180e-04	3.756	0	0
Degradation of CDH1	R-HSA-9766229	1.784093e-04	3.749	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.813329e-04	3.742	0	0
Chromosome Maintenance	R-HSA-73886	1.891156e-04	3.723	0	0
MAP2K and MAPK activation	R-HSA-5674135	1.895041e-04	3.722	0	0
PKR-mediated signaling	R-HSA-9833482	1.926312e-04	3.715	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.025466e-04	3.693	0	0
Translation	R-HSA-72766	2.088833e-04	3.680	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.106893e-04	3.676	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	2.106893e-04	3.676	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.171925e-04	3.663	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.173338e-04	3.663	0	0
Regulation of RAS by GAPs	R-HSA-5658442	2.242033e-04	3.649	0	0
Amyloid fiber formation	R-HSA-977225	2.302024e-04	3.638	0	0
Homology Directed Repair	R-HSA-5693538	2.462163e-04	3.609	0	0
Signaling by PDGFR in disease	R-HSA-9671555	2.604022e-04	3.584	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	2.800030e-04	3.553	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.825510e-04	3.549	0	0
Formation of annular gap junctions	R-HSA-196025	2.848729e-04	3.545	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	3.061119e-04	3.514	0	0
Signaling by EGFR	R-HSA-177929	3.243780e-04	3.489	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.979104e-04	3.400	0	0
Neutrophil degranulation	R-HSA-6798695	4.558999e-04	3.341	0	0
FLT3 Signaling	R-HSA-9607240	4.060545e-04	3.391	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.394492e-04	3.357	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.288621e-04	3.368	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	4.036305e-04	3.394	0	0
Activation of BH3-only proteins	R-HSA-114452	4.155947e-04	3.381	0	0
MHC class II antigen presentation	R-HSA-2132295	4.858292e-04	3.314	0	0
Gap junction degradation	R-HSA-190873	5.027365e-04	3.299	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	5.051802e-04	3.297	0	0
Telomere Maintenance	R-HSA-157579	5.105515e-04	3.292	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	5.268061e-04	3.278	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	5.355958e-04	3.271	0	0
Semaphorin interactions	R-HSA-373755	5.381503e-04	3.269	0	0
Downstream signal transduction	R-HSA-186763	5.481327e-04	3.261	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	5.531157e-04	3.257	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	5.538884e-04	3.257	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	5.538884e-04	3.257	0	0
Erythropoietin activates RAS	R-HSA-9027284	6.618143e-04	3.179	0	0
Cell-extracellular matrix interactions	R-HSA-446353	6.618143e-04	3.179	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	6.618143e-04	3.179	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	6.780569e-04	3.169	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.960971e-04	3.157	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	7.002221e-04	3.155	0	0
G1/S Transition	R-HSA-69206	7.135142e-04	3.147	0	0
S Phase	R-HSA-69242	7.612694e-04	3.118	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	7.651609e-04	3.116	0	0
VLDLR internalisation and degradation	R-HSA-8866427	7.651609e-04	3.116	0	0
Selenoamino acid metabolism	R-HSA-2408522	8.004357e-04	3.097	0	0
Signaling by SCF-KIT	R-HSA-1433557	8.055623e-04	3.094	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	8.117165e-04	3.091	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.314228e-04	3.080	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	8.314228e-04	3.080	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	8.527200e-04	3.069	0	0
Protein folding	R-HSA-391251	8.738354e-04	3.059	0	0
ISG15 antiviral mechanism	R-HSA-1169408	8.804578e-04	3.055	0	0
Regulation of TP53 Degradation	R-HSA-6804757	8.947859e-04	3.048	0	0
FLT3 signaling in disease	R-HSA-9682385	8.947859e-04	3.048	0	0
Signaling by Erythropoietin	R-HSA-9006335	9.347273e-04	3.029	0	0
Late endosomal microautophagy	R-HSA-9615710	9.347273e-04	3.029	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.160611e-03	2.935	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.160933e-03	2.935	0	0
PIP3 activates AKT signaling	R-HSA-1257604	1.074935e-03	2.969	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.143028e-03	2.942	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.160933e-03	2.935	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	1.004562e-03	2.998	0	0
Base Excision Repair	R-HSA-73884	1.143028e-03	2.942	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.181054e-03	2.928	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	1.182177e-03	2.927	0	0
Signaling by KIT in disease	R-HSA-9669938	1.188800e-03	2.925	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	1.188800e-03	2.925	0	0
Gene Silencing by RNA	R-HSA-211000	1.195548e-03	2.922	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.252139e-03	2.902	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	1.324728e-03	2.878	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.324728e-03	2.878	0	0
Switching of origins to a post-replicative state	R-HSA-69052	1.364218e-03	2.865	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.387861e-03	2.858	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	1.443629e-03	2.841	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	1.443629e-03	2.841	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	1.443629e-03	2.841	0	0
Interferon Signaling	R-HSA-913531	1.469446e-03	2.833	0	0
Chaperonin-mediated protein folding	R-HSA-390466	1.494970e-03	2.825	0	0
Negative regulation of MET activity	R-HSA-6807004	1.524943e-03	2.817	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.524943e-03	2.817	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.559160e-03	2.807	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	1.590658e-03	2.798	0	0
Signaling by NOTCH4	R-HSA-9013694	1.597363e-03	2.797	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.692744e-03	2.771	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.706781e-03	2.768	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	1.836716e-03	2.736	0	0
Signaling by MET	R-HSA-6806834	1.915877e-03	2.718	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.915877e-03	2.718	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	1.955013e-03	2.709	0	0
Orc1 removal from chromatin	R-HSA-68949	1.998150e-03	2.699	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	2.043966e-03	2.690	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	2.043966e-03	2.690	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	2.043966e-03	2.690	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.441710e-03	2.612	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	2.171669e-03	2.663	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.389755e-03	2.622	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	2.552493e-03	2.593	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.389755e-03	2.622	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	2.268598e-03	2.644	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	2.171669e-03	2.663	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.341593e-03	2.630	0	0
HIV Infection	R-HSA-162906	2.316893e-03	2.635	0	0
Signaling by Interleukins	R-HSA-449147	2.305440e-03	2.637	0	0
Signaling by NTRKs	R-HSA-166520	2.344929e-03	2.630	0	0
Co-inhibition by PD-1	R-HSA-389948	2.198802e-03	2.658	0	0
Adaptive Immune System	R-HSA-1280218	2.504500e-03	2.601	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.441710e-03	2.612	0	0
Gap junction trafficking	R-HSA-190828	2.430554e-03	2.614	0	0
Vesicle-mediated transport	R-HSA-5653656	2.572617e-03	2.590	0	0
Gap junction trafficking and regulation	R-HSA-157858	2.654525e-03	2.576	0	0
Interleukin-7 signaling	R-HSA-1266695	2.717249e-03	2.566	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.737961e-03	2.563	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.737961e-03	2.563	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	2.859098e-03	2.544	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.912822e-03	2.536	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	2.912822e-03	2.536	0	0
DNA Repair	R-HSA-73894	2.915246e-03	2.535	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	3.016942e-03	2.520	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.016942e-03	2.520	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	3.167262e-03	2.499	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	3.167262e-03	2.499	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	3.167262e-03	2.499	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	3.167262e-03	2.499	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	3.167262e-03	2.499	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	3.167262e-03	2.499	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	3.167262e-03	2.499	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	3.167262e-03	2.499	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	3.167262e-03	2.499	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	3.167262e-03	2.499	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	3.167262e-03	2.499	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	3.237393e-03	2.490	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.323087e-03	2.478	0	0
Metalloprotease DUBs	R-HSA-5689901	3.488222e-03	2.457	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	3.530509e-03	2.452	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.618500e-03	2.441	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.618500e-03	2.441	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.618500e-03	2.441	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	3.618500e-03	2.441	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	3.796149e-03	2.421	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.859020e-03	2.414	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	3.969891e-03	2.401	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	3.969891e-03	2.401	0	0
SOS-mediated signalling	R-HSA-112412	4.113526e-03	2.386	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.185111e-03	2.378	0	0
PTEN Regulation	R-HSA-6807070	4.254965e-03	2.371	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	4.317075e-03	2.365	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	4.318005e-03	2.365	0	0
Regulation of mitotic cell cycle	R-HSA-453276	4.318005e-03	2.365	0	0
Stabilization of p53	R-HSA-69541	4.318420e-03	2.365	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	4.318420e-03	2.365	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.391432e-03	2.357	0	0
Amplification of signal from the kinetochores	R-HSA-141424	4.391432e-03	2.357	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	4.464918e-03	2.350	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	4.651469e-03	2.332	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	4.727161e-03	2.325	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	4.737174e-03	2.324	0	0
Regulation of Apoptosis	R-HSA-169911	4.737174e-03	2.324	0	0
Signalling to ERKs	R-HSA-187687	4.737174e-03	2.324	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	4.741808e-03	2.324	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.366038e-03	2.270	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	5.556810e-03	2.255	0	0
RET signaling	R-HSA-8853659	5.770097e-03	2.239	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	5.257109e-03	2.279	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	5.257109e-03	2.279	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	5.421412e-03	2.266	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	4.972727e-03	2.303	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	5.074282e-03	2.295	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	5.924669e-03	2.227	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	5.924669e-03	2.227	0	0
Epigenetic regulation of gene expression	R-HSA-212165	5.230236e-03	2.281	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	5.366038e-03	2.270	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	6.010348e-03	2.221	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	5.574751e-03	2.254	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	6.010348e-03	2.221	0	0
Host Interactions of HIV factors	R-HSA-162909	5.913865e-03	2.228	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.614217e-03	2.251	0	0
MITF-M-dependent gene expression	R-HSA-9856651	4.809880e-03	2.318	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	6.160723e-03	2.210	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	6.222197e-03	2.206	0	0
SARS-CoV-2 Infection	R-HSA-9694516	6.222271e-03	2.206	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	6.269999e-03	2.203	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	6.269999e-03	2.203	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	6.337986e-03	2.198	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	6.665429e-03	2.176	0	0
DAG and IP3 signaling	R-HSA-1489509	6.665429e-03	2.176	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	6.665429e-03	2.176	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	6.665429e-03	2.176	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	6.924221e-03	2.160	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	6.954092e-03	2.158	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.186801e-03	2.143	0	0
Signaling by NOTCH3	R-HSA-9012852	7.186801e-03	2.143	0	0
ER-Phagosome pathway	R-HSA-1236974	7.219226e-03	2.142	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	7.242275e-03	2.140	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	7.438673e-03	2.129	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	7.438673e-03	2.129	0	0
HDMs demethylate histones	R-HSA-3214842	7.438673e-03	2.129	0	0
Sema4D in semaphorin signaling	R-HSA-400685	7.438673e-03	2.129	0	0
Long-term potentiation	R-HSA-9620244	7.438673e-03	2.129	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.482279e-03	2.126	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.482279e-03	2.126	0	0
Vpu mediated degradation of CD4	R-HSA-180534	7.724643e-03	2.112	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	7.887958e-03	2.103	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	7.887958e-03	2.103	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	7.887958e-03	2.103	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	8.165878e-03	2.088	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.165878e-03	2.088	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.165878e-03	2.088	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	8.165878e-03	2.088	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	8.165878e-03	2.088	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	8.172038e-03	2.088	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	8.591451e-03	2.066	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	8.874697e-03	2.052	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	9.115338e-03	2.040	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.241868e-03	2.034	0	0
Hemostasis	R-HSA-109582	9.282530e-03	2.032	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.340169e-03	2.030	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	9.621338e-03	2.017	0	0
HCMV Early Events	R-HSA-9609690	9.713560e-03	2.013	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.749963e-03	2.011	0	0
mTORC1-mediated signalling	R-HSA-166208	9.979957e-03	2.001	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.979957e-03	2.001	0	0
TCR signaling	R-HSA-202403	1.009545e-02	1.996	0	0
Nucleotide Excision Repair	R-HSA-5696398	1.043059e-02	1.982	0	0
Signaling by FGFR4	R-HSA-5654743	1.046490e-02	1.980	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	1.046490e-02	1.980	0	0
Rap1 signalling	R-HSA-392517	1.055458e-02	1.977	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.065922e-02	1.972	0	0
SARS-CoV Infections	R-HSA-9679506	1.069466e-02	1.971	0	0
PCP/CE pathway	R-HSA-4086400	1.084511e-02	1.965	0	0
Negative regulation of FLT3	R-HSA-9706369	1.085437e-02	1.964	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	1.085437e-02	1.964	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.120861e-02	1.950	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	1.120861e-02	1.950	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.142294e-02	1.942	0	0
Regulation of TP53 Activity	R-HSA-5633007	1.151666e-02	1.939	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.158965e-02	1.936	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	1.158965e-02	1.936	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.377382e-02	1.861	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	1.377382e-02	1.861	0	0
Folding of actin by CCT/TriC	R-HSA-390450	1.377382e-02	1.861	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	1.439896e-02	1.842	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.439896e-02	1.842	0	0
Deadenylation of mRNA	R-HSA-429947	1.540036e-02	1.812	0	0
Protein ubiquitination	R-HSA-8852135	1.402119e-02	1.853	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.426514e-02	1.846	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.414650e-02	1.849	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.183302e-02	1.927	0	0
CaM pathway	R-HSA-111997	1.335456e-02	1.874	0	0
Calmodulin induced events	R-HSA-111933	1.335456e-02	1.874	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.393364e-02	1.856	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	1.227102e-02	1.911	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	1.377382e-02	1.861	0	0
Josephin domain DUBs	R-HSA-5689877	1.377382e-02	1.861	0	0
HIV Life Cycle	R-HSA-162587	1.416266e-02	1.849	0	0
Synthesis of DNA	R-HSA-69239	1.276532e-02	1.894	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	1.426514e-02	1.846	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.402119e-02	1.853	0	0
Signaling by FGFR3	R-HSA-5654741	1.431158e-02	1.844	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	1.377382e-02	1.861	0	0
Activation of ATR in response to replication stress	R-HSA-176187	1.503266e-02	1.823	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	1.393364e-02	1.856	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.393364e-02	1.856	0	0
Selective autophagy	R-HSA-9663891	1.169642e-02	1.932	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.431158e-02	1.844	0	0
Antigen processing-Cross presentation	R-HSA-1236975	1.408154e-02	1.851	0	0
Neurodegenerative Diseases	R-HSA-8863678	1.540036e-02	1.812	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.540036e-02	1.812	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	1.335456e-02	1.874	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.540036e-02	1.812	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.414650e-02	1.849	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.569872e-02	1.804	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.580289e-02	1.801	0	0
Degradation of DVL	R-HSA-4641258	1.580289e-02	1.801	0	0
Degradation of AXIN	R-HSA-4641257	1.580289e-02	1.801	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.580289e-02	1.801	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.670634e-02	1.777	0	0
Ion homeostasis	R-HSA-5578775	1.671316e-02	1.777	0	0
Hedgehog 'off' state	R-HSA-5610787	1.672568e-02	1.777	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	1.672810e-02	1.777	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	1.686071e-02	1.773	0	0
Platelet calcium homeostasis	R-HSA-418360	1.686071e-02	1.773	0	0
Regulation of PTEN localization	R-HSA-8948747	1.743893e-02	1.758	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.743893e-02	1.758	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.789316e-02	1.747	0	0
G-protein mediated events	R-HSA-112040	1.849408e-02	1.733	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	1.881431e-02	1.726	0	0
Ca-dependent events	R-HSA-111996	1.898559e-02	1.722	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.899166e-02	1.721	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.903712e-02	1.720	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	1.918080e-02	1.717	0	0
mRNA 3'-end processing	R-HSA-72187	1.918080e-02	1.717	0	0
RNA Polymerase II Transcription	R-HSA-73857	1.985862e-02	1.702	0	0
DAP12 signaling	R-HSA-2424491	2.021200e-02	1.694	0	0
Autophagy	R-HSA-9612973	2.025128e-02	1.694	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	2.030974e-02	1.692	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.083706e-02	1.681	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.106934e-02	1.676	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	2.170623e-02	1.663	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	2.197984e-02	1.658	0	0
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	2.216538e-02	1.654	0	0
Signaling by RAS GAP mutants	R-HSA-9753510	2.216538e-02	1.654	0	0
Myogenesis	R-HSA-525793	2.275303e-02	1.643	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.275303e-02	1.643	0	0
Immune System	R-HSA-168256	2.280744e-02	1.642	0	0
EGFR downregulation	R-HSA-182971	2.403034e-02	1.619	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	2.403034e-02	1.619	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	2.403034e-02	1.619	0	0
Opioid Signalling	R-HSA-111885	2.443214e-02	1.612	0	0
Spry regulation of FGF signaling	R-HSA-1295596	2.452253e-02	1.610	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.452253e-02	1.610	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.452253e-02	1.610	0	0
p38MAPK events	R-HSA-171007	2.452253e-02	1.610	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.481167e-02	1.605	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.496783e-02	1.603	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	2.496783e-02	1.603	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.496783e-02	1.603	0	0
Cyclin D associated events in G1	R-HSA-69231	2.531446e-02	1.597	0	0
G1 Phase	R-HSA-69236	2.531446e-02	1.597	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	2.552794e-02	1.593	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.552794e-02	1.593	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.586961e-02	1.587	0	0
Cellular response to hypoxia	R-HSA-1234174	2.689030e-02	1.570	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	2.725615e-02	1.565	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.725615e-02	1.565	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	2.758813e-02	1.559	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	2.831647e-02	1.548	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.831647e-02	1.548	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.834828e-02	1.547	0	0
GPVI-mediated activation cascade	R-HSA-114604	2.892547e-02	1.539	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	2.900996e-02	1.537	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	2.900996e-02	1.537	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	3.005940e-02	1.522	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	3.056311e-02	1.515	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	3.081807e-02	1.511	0	0
PLC beta mediated events	R-HSA-112043	3.098784e-02	1.509	0	0
Prolonged ERK activation events	R-HSA-169893	3.106749e-02	1.508	0	0
TNF signaling	R-HSA-75893	3.180989e-02	1.497	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.180989e-02	1.497	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.198144e-02	1.495	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.209762e-02	1.494	0	0
Maturation of protein E	R-HSA-9694493	3.209762e-02	1.494	0	0
Maturation of protein E	R-HSA-9683683	3.209762e-02	1.494	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.225487e-02	1.491	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	3.252367e-02	1.488	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.319655e-02	1.479	0	0
G-protein beta:gamma signalling	R-HSA-397795	3.319655e-02	1.479	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	3.319655e-02	1.479	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.319655e-02	1.479	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.319655e-02	1.479	0	0
Macroautophagy	R-HSA-1632852	3.327726e-02	1.478	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	3.334452e-02	1.477	0	0
Disorders of Nervous System Development	R-HSA-9697154	3.334452e-02	1.477	0	0
Pervasive developmental disorders	R-HSA-9005895	3.334452e-02	1.477	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	3.334452e-02	1.477	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	3.344031e-02	1.476	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	3.344031e-02	1.476	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.431324e-02	1.465	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	3.431324e-02	1.465	0	0
Calcineurin activates NFAT	R-HSA-2025928	3.431324e-02	1.465	0	0
ALK mutants bind TKIs	R-HSA-9700645	3.431324e-02	1.465	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.455002e-02	1.462	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.467261e-02	1.460	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	3.517345e-02	1.454	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	3.581660e-02	1.446	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	3.587129e-02	1.445	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	3.587129e-02	1.445	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	3.587129e-02	1.445	0	0
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	3.587129e-02	1.445	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	3.587129e-02	1.445	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	3.587129e-02	1.445	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.593932e-02	1.444	0	0
Platelet degranulation	R-HSA-114608	3.602205e-02	1.443	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	3.672304e-02	1.435	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.732885e-02	1.428	0	0
MTOR signalling	R-HSA-165159	3.821015e-02	1.418	0	0
Disorders of Developmental Biology	R-HSA-9675151	3.869124e-02	1.412	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	3.869124e-02	1.412	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	3.870176e-02	1.412	0	0
MET interacts with TNS proteins	R-HSA-8875513	3.890963e-02	1.410	0	0
PI3K/AKT activation	R-HSA-198203	4.556767e-02	1.341	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.556767e-02	1.341	0	0
PECAM1 interactions	R-HSA-210990	5.877827e-02	1.231	0	0
Retrograde neurotrophin signalling	R-HSA-177504	5.323955e-02	1.274	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.323955e-02	1.274	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	4.744571e-02	1.324	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.193005e-02	1.377	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	5.012785e-02	1.300	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	5.929597e-02	1.227	0	0
Trafficking of AMPA receptors	R-HSA-399719	5.160693e-02	1.287	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.743823e-02	1.241	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	5.508081e-02	1.259	0	0
Signaling by ERBB4	R-HSA-1236394	3.974483e-02	1.401	0	0
IRE1alpha activates chaperones	R-HSA-381070	4.988272e-02	1.302	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	4.735615e-02	1.325	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	4.735615e-02	1.325	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	4.735615e-02	1.325	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	5.929597e-02	1.227	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	4.534412e-02	1.343	0	0
Frs2-mediated activation	R-HSA-170968	4.256379e-02	1.371	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	5.012785e-02	1.300	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	5.942054e-02	1.226	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	4.467706e-02	1.350	0	0
Co-stimulation by CD28	R-HSA-389356	4.245426e-02	1.372	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	4.459547e-02	1.351	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	4.778026e-02	1.321	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	5.670456e-02	1.246	0	0
Budding and maturation of HIV virion	R-HSA-162588	5.160693e-02	1.287	0	0
Gene expression (Transcription)	R-HSA-74160	4.319196e-02	1.365	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	5.012785e-02	1.300	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	5.164453e-02	1.287	0	0
Generic Transcription Pathway	R-HSA-212436	4.178718e-02	1.379	0	0
Interleukin-27 signaling	R-HSA-9020956	4.556767e-02	1.341	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	5.887454e-02	1.230	0	0
HCMV Infection	R-HSA-9609646	4.865656e-02	1.313	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	5.736892e-02	1.241	0	0
Signaling by FGFR1	R-HSA-5654736	5.743823e-02	1.241	0	0
Signaling by NOTCH1	R-HSA-1980143	4.822183e-02	1.317	0	0
Signaling by TGFB family members	R-HSA-9006936	5.818757e-02	1.235	0	0
Protein-protein interactions at synapses	R-HSA-6794362	4.011444e-02	1.397	0	0
G alpha (12/13) signalling events	R-HSA-416482	5.791532e-02	1.237	0	0
COPI-mediated anterograde transport	R-HSA-6807878	5.152530e-02	1.288	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	5.135573e-02	1.289	0	0
Death Receptor Signaling	R-HSA-73887	3.965318e-02	1.402	0	0
Signaling by Hedgehog	R-HSA-5358351	4.044536e-02	1.393	0	0
Glycogen metabolism	R-HSA-8982491	5.033013e-02	1.298	0	0
Nef and signal transduction	R-HSA-164944	4.594519e-02	1.338	0	0
Pexophagy	R-HSA-9664873	4.556767e-02	1.341	0	0
Hedgehog 'on' state	R-HSA-5632684	5.045566e-02	1.297	0	0
Assembly Of The HIV Virion	R-HSA-175474	5.012785e-02	1.300	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	5.743823e-02	1.241	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	4.993051e-02	1.302	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	5.978980e-02	1.223	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	5.981650e-02	1.223	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	6.048506e-02	1.218	0	0
Ca2+ pathway	R-HSA-4086398	6.083963e-02	1.216	0	0
Signaling by PDGF	R-HSA-186797	6.086510e-02	1.216	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	6.209374e-02	1.207	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.262345e-02	1.203	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.262345e-02	1.203	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.262345e-02	1.203	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	6.262345e-02	1.203	0	0
Cilium Assembly	R-HSA-5617833	6.292390e-02	1.201	0	0
Sensory processing of sound	R-HSA-9659379	6.323884e-02	1.199	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	6.366118e-02	1.196	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	6.383762e-02	1.195	0	0
Potential therapeutics for SARS	R-HSA-9679191	6.484410e-02	1.188	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	6.525977e-02	1.185	0	0
DCC mediated attractive signaling	R-HSA-418885	6.540164e-02	1.184	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.540164e-02	1.184	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.540164e-02	1.184	0	0
Translesion synthesis by REV1	R-HSA-110312	6.540164e-02	1.184	0	0
Protein methylation	R-HSA-8876725	6.540164e-02	1.184	0	0
Ovarian tumor domain proteases	R-HSA-5689896	6.629022e-02	1.179	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.629022e-02	1.179	0	0
Neurexins and neuroligins	R-HSA-6794361	6.649770e-02	1.177	0	0
Regulation of necroptotic cell death	R-HSA-5675482	6.796557e-02	1.168	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	6.796557e-02	1.168	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.848434e-02	1.164	0	0
Translesion Synthesis by POLH	R-HSA-110320	6.848434e-02	1.164	0	0
Other interleukin signaling	R-HSA-449836	6.848434e-02	1.164	0	0
Signaling by FGFR2	R-HSA-5654738	6.888963e-02	1.162	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	6.888963e-02	1.162	0	0
Growth hormone receptor signaling	R-HSA-982772	6.945474e-02	1.158	0	0
Syndecan interactions	R-HSA-3000170	6.945474e-02	1.158	0	0
Glycolysis	R-HSA-70171	7.035522e-02	1.153	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.260876e-02	1.139	0	0
Manipulation of host energy metabolism	R-HSA-9636667	7.337810e-02	1.134	0	0
Breakdown of the nuclear lamina	R-HSA-352238	7.337810e-02	1.134	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	7.364428e-02	1.133	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	7.394814e-02	1.131	0	0
Integration of provirus	R-HSA-162592	7.394814e-02	1.131	0	0
Translesion synthesis by POLI	R-HSA-5656121	7.905596e-02	1.102	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	7.905596e-02	1.102	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	7.905596e-02	1.102	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	7.928032e-02	1.101	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	7.928032e-02	1.101	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	8.061454e-02	1.094	0	0
Type I hemidesmosome assembly	R-HSA-446107	8.205248e-02	1.086	0	0
Interleukin-23 signaling	R-HSA-9020933	8.205248e-02	1.086	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	8.205248e-02	1.086	0	0
Activation of RAS in B cells	R-HSA-1169092	8.205248e-02	1.086	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	8.205248e-02	1.086	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	8.205248e-02	1.086	0	0
Modulation by Mtb of host immune system	R-HSA-9637628	8.205248e-02	1.086	0	0
RAS processing	R-HSA-9648002	8.400067e-02	1.076	0	0
Plasma lipoprotein clearance	R-HSA-8964043	8.400067e-02	1.076	0	0
Infectious disease	R-HSA-5663205	8.445551e-02	1.073	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	8.498994e-02	1.071	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	8.498994e-02	1.071	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	8.498994e-02	1.071	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	8.498994e-02	1.071	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	8.498994e-02	1.071	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	8.648479e-02	1.063	0	0
IRS activation	R-HSA-74713	8.648479e-02	1.063	0	0
Nectin/Necl trans heterodimerization	R-HSA-420597	8.648479e-02	1.063	0	0
Dual Incision in GG-NER	R-HSA-5696400	8.729194e-02	1.059	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	8.729194e-02	1.059	0	0
Signaling by NOTCH2	R-HSA-1980145	8.729194e-02	1.059	0	0
Developmental Cell Lineages	R-HSA-9734767	8.955916e-02	1.048	0	0
Proteasome assembly	R-HSA-9907900	8.961400e-02	1.048	0	0
Activation of the pre-replicative complex	R-HSA-68962	9.029892e-02	1.044	0	0
MET activates RAS signaling	R-HSA-8851805	9.103926e-02	1.041	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	9.103926e-02	1.041	0	0
Interleukin-35 Signalling	R-HSA-8984722	9.103926e-02	1.041	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	9.103926e-02	1.041	0	0
Regulation of IFNG signaling	R-HSA-877312	9.103926e-02	1.041	0	0
GRB2 events in EGFR signaling	R-HSA-179812	9.103926e-02	1.041	0	0
IRAK1 recruits IKK complex	R-HSA-937039	9.103926e-02	1.041	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	9.103926e-02	1.041	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	9.103926e-02	1.041	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	9.103926e-02	1.041	0	0
p75NTR recruits signalling complexes	R-HSA-209543	9.103926e-02	1.041	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	9.418522e-02	1.026	0	0
Translesion synthesis by POLK	R-HSA-5655862	9.418522e-02	1.026	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.418522e-02	1.026	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.418522e-02	1.026	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	9.431155e-02	1.025	0	0
Basigin interactions	R-HSA-210991	9.431155e-02	1.025	0	0
Signalling to RAS	R-HSA-167044	9.431155e-02	1.025	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	9.431155e-02	1.025	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.646398e-02	1.016	0	0
Oncogene Induced Senescence	R-HSA-2559585	9.808087e-02	1.008	0	0
NRAGE signals death through JNK	R-HSA-193648	9.820865e-02	1.008	0	0
Somitogenesis	R-HSA-9824272	9.924958e-02	1.003	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	1.021737e-01	0.991	0	0
MAPK1 (ERK2) activation	R-HSA-112411	1.040768e-01	0.983	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.040768e-01	0.983	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.040768e-01	0.983	0	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	1.040768e-01	0.983	0	0
Unwinding of DNA	R-HSA-176974	1.040768e-01	0.983	0	0
Regulated Necrosis	R-HSA-5218859	1.042114e-01	0.982	0	0
PKMTs methylate histone lysines	R-HSA-3214841	1.043725e-01	0.981	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.073758e-01	0.969	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	1.089969e-01	0.963	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.099767e-01	0.959	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	1.099767e-01	0.959	0	0
Interleukin-6 signaling	R-HSA-1059683	1.099767e-01	0.959	0	0
Interleukin-1 signaling	R-HSA-9020702	1.130410e-01	0.947	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	1.136455e-01	0.944	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.143709e-01	0.942	0	0
G0 and Early G1	R-HSA-1538133	1.148944e-01	0.940	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	1.148944e-01	0.940	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.163535e-01	0.934	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.163535e-01	0.934	0	0
Phosphorylation of Emi1	R-HSA-176417	1.163535e-01	0.934	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	1.163535e-01	0.934	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.163535e-01	0.934	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.163535e-01	0.934	0	0
Regulation of TP53 Expression	R-HSA-6804754	1.187498e-01	0.925	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.187498e-01	0.925	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.187498e-01	0.925	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	1.187498e-01	0.925	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	1.200542e-01	0.921	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	1.200542e-01	0.921	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	1.200542e-01	0.921	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.203093e-01	0.920	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.214385e-01	0.916	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.220381e-01	0.914	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.241287e-01	0.906	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.248228e-01	0.904	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.273611e-01	0.895	0	0
Drug resistance of FLT3 mutants	R-HSA-9702506	1.372384e-01	0.863	0	0
Drug resistance of KIT mutants	R-HSA-9669937	1.372384e-01	0.863	0	0
Drug resistance of PDGFR mutants	R-HSA-9674415	1.372384e-01	0.863	0	0
KIT mutants bind TKIs	R-HSA-9669921	1.372384e-01	0.863	0	0
FLT3 mutants bind TKIs	R-HSA-9702509	1.372384e-01	0.863	0	0
PDGFR mutants bind TKIs	R-HSA-9674428	1.372384e-01	0.863	0	0
quizartinib-resistant FLT3 mutants	R-HSA-9702620	1.372384e-01	0.863	0	0
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.372384e-01	0.863	0	0
midostaurin-resistant FLT3 mutants	R-HSA-9702600	1.372384e-01	0.863	0	0
pexidartinib-resistant FLT3 mutants	R-HSA-9702605	1.372384e-01	0.863	0	0
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.372384e-01	0.863	0	0
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.372384e-01	0.863	0	0
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.372384e-01	0.863	0	0
Imatinib-resistant KIT mutants	R-HSA-9669917	1.372384e-01	0.863	0	0
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.372384e-01	0.863	0	0
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.372384e-01	0.863	0	0
crenolanib-resistant FLT3 mutants	R-HSA-9702581	1.372384e-01	0.863	0	0
gilteritinib-resistant FLT3 mutants	R-HSA-9702590	1.372384e-01	0.863	0	0
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.372384e-01	0.863	0	0
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	1.372384e-01	0.863	0	0
ponatinib-resistant FLT3 mutants	R-HSA-9702614	1.372384e-01	0.863	0	0
semaxanib-resistant FLT3 mutants	R-HSA-9702577	1.372384e-01	0.863	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.372384e-01	0.863	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.372384e-01	0.863	0	0
lestaurtinib-resistant FLT3 mutants	R-HSA-9702596	1.372384e-01	0.863	0	0
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.372384e-01	0.863	0	0
sorafenib-resistant FLT3 mutants	R-HSA-9702624	1.372384e-01	0.863	0	0
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.372384e-01	0.863	0	0
Masitinib-resistant KIT mutants	R-HSA-9669924	1.372384e-01	0.863	0	0
tandutinib-resistant FLT3 mutants	R-HSA-9702636	1.372384e-01	0.863	0	0
KW2449-resistant FLT3 mutants	R-HSA-9702569	1.372384e-01	0.863	0	0
linifanib-resistant FLT3 mutants	R-HSA-9702998	1.372384e-01	0.863	0	0
tamatinib-resistant FLT3 mutants	R-HSA-9703009	1.372384e-01	0.863	0	0
sunitinib-resistant FLT3 mutants	R-HSA-9702632	1.372384e-01	0.863	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.556492e-01	0.592	0	0
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.556492e-01	0.592	0	0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	R-HSA-5619043	2.556492e-01	0.592	0	0
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	2.556492e-01	0.592	0	0
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	2.556492e-01	0.592	0	0
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	R-HSA-5619110	2.556492e-01	0.592	0	0
TICAM1 deficiency - HSE	R-HSA-5602566	2.556492e-01	0.592	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.556492e-01	0.592	0	0
MET activates STAT3	R-HSA-8875791	1.691232e-01	0.772	0	0
Axonal growth stimulation	R-HSA-209563	1.691232e-01	0.772	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.691232e-01	0.772	0	0
MET activates PTPN11	R-HSA-8865999	1.691232e-01	0.772	0	0
Signaling by LTK in cancer	R-HSA-9842640	1.494588e-01	0.825	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	1.494588e-01	0.825	0	0
Erythropoietin activates STAT5	R-HSA-9027283	1.494588e-01	0.825	0	0
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	2.222720e-01	0.653	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	2.222720e-01	0.653	0	0
Activated NTRK2 signals through PLCG1	R-HSA-9026527	2.222720e-01	0.653	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	2.222720e-01	0.653	0	0
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	2.222720e-01	0.653	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.222720e-01	0.653	0	0
2-LTR circle formation	R-HSA-164843	1.284817e-01	0.891	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	1.851432e-01	0.732	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	1.851432e-01	0.732	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	1.851432e-01	0.732	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.851432e-01	0.732	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	1.851432e-01	0.732	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	1.851432e-01	0.732	0	0
Regulation of KIT signaling	R-HSA-1433559	1.306534e-01	0.884	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	2.227596e-01	0.652	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	2.227596e-01	0.652	0	0
MET receptor recycling	R-HSA-8875656	2.227596e-01	0.652	0	0
Activation of RAC1	R-HSA-428540	1.833714e-01	0.737	0	0
Signaling by AMER1 mutants	R-HSA-4839748	1.833714e-01	0.737	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	1.833714e-01	0.737	0	0
SHC1 events in EGFR signaling	R-HSA-180336	1.529360e-01	0.815	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	1.286922e-01	0.890	0	0
Phosphorylation of the APC/C	R-HSA-176412	1.766696e-01	0.753	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.766696e-01	0.753	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	2.132652e-01	0.671	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.132652e-01	0.671	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.132652e-01	0.671	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	2.132652e-01	0.671	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.132652e-01	0.671	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.132652e-01	0.671	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.132652e-01	0.671	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.132652e-01	0.671	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	1.417429e-01	0.848	0	0
Co-inhibition by CTLA4	R-HSA-389513	1.683842e-01	0.774	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.351239e-01	0.869	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.443813e-01	0.612	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.443813e-01	0.612	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.443813e-01	0.612	0	0
Integrin signaling	R-HSA-354192	1.284439e-01	0.891	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.511008e-01	0.821	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	1.511008e-01	0.821	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	2.277978e-01	0.642	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.277978e-01	0.642	0	0
TGFBR3 expression	R-HSA-9839394	1.786252e-01	0.748	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.485779e-01	0.828	0	0
GAB1 signalosome	R-HSA-180292	2.548245e-01	0.594	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.629504e-01	0.788	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.230821e-01	0.652	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.809161e-01	0.743	0	0
MET promotes cell motility	R-HSA-8875878	2.254019e-01	0.647	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.427941e-01	0.615	0	0
Dual incision in TC-NER	R-HSA-6782135	1.842626e-01	0.735	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	1.733924e-01	0.761	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	1.445781e-01	0.840	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	1.738231e-01	0.760	0	0
Generation of second messenger molecules	R-HSA-202433	1.629504e-01	0.788	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.110764e-01	0.676	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	2.230821e-01	0.652	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	1.579279e-01	0.802	0	0
Signaling by Leptin	R-HSA-2586552	1.284817e-01	0.891	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.370395e-01	0.625	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	1.851432e-01	0.732	0	0
DNA strand elongation	R-HSA-69190	2.039913e-01	0.690	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.713452e-01	0.766	0	0
Interleukin-9 signaling	R-HSA-8985947	2.227596e-01	0.652	0	0
Interleukin-2 signaling	R-HSA-9020558	1.550090e-01	0.810	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	1.529360e-01	0.815	0	0
Regulation of CDH11 function	R-HSA-9762292	1.284817e-01	0.891	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	1.766696e-01	0.753	0	0
Netrin-1 signaling	R-HSA-373752	2.438029e-01	0.613	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.286922e-01	0.890	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	1.511008e-01	0.821	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	1.679399e-01	0.775	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	2.190718e-01	0.659	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	1.445453e-01	0.840	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.286922e-01	0.890	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	1.899376e-01	0.721	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	2.190718e-01	0.659	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.445453e-01	0.840	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.533542e-01	0.814	0	0
Signal transduction by L1	R-HSA-445144	1.683842e-01	0.774	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	2.000784e-01	0.699	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	1.979270e-01	0.703	0	0
Platelet homeostasis	R-HSA-418346	2.237742e-01	0.650	0	0
Activation and oligomerization of BAK protein	R-HSA-111452	2.556492e-01	0.592	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	2.222720e-01	0.653	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.679399e-01	0.775	0	0
Platelet sensitization by LDL	R-HSA-432142	2.548245e-01	0.594	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.417429e-01	0.848	0	0
IGF1R signaling cascade	R-HSA-2428924	1.850352e-01	0.733	0	0
STING mediated induction of host immune responses	R-HSA-1834941	1.479342e-01	0.830	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	1.786252e-01	0.748	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.348824e-01	0.870	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	1.476975e-01	0.831	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.683842e-01	0.774	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	1.489483e-01	0.827	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.284439e-01	0.891	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	1.306534e-01	0.884	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	2.227596e-01	0.652	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	1.634125e-01	0.787	0	0
The NLRP3 inflammasome	R-HSA-844456	1.479342e-01	0.830	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.479342e-01	0.830	0	0
Transmission across Chemical Synapses	R-HSA-112315	2.001791e-01	0.699	0	0
Signaling by FGFR in disease	R-HSA-1226099	2.370395e-01	0.625	0	0
Activation, translocation and oligomerization of BAX	R-HSA-114294	2.556492e-01	0.592	0	0
Inhibition of PKR	R-HSA-169131	2.556492e-01	0.592	0	0
MTF1 activates gene expression	R-HSA-5660489	2.222720e-01	0.653	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.222720e-01	0.653	0	0
MAPK3 (ERK1) activation	R-HSA-110056	1.284817e-01	0.891	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	1.284817e-01	0.891	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.306534e-01	0.884	0	0
Co-stimulation by ICOS	R-HSA-9927354	2.227596e-01	0.652	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	1.286922e-01	0.890	0	0
Signaling by LTK	R-HSA-9842663	2.132652e-01	0.671	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.443813e-01	0.612	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	2.277978e-01	0.642	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.679399e-01	0.775	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	2.404207e-01	0.619	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.437709e-01	0.613	0	0
Glucose metabolism	R-HSA-70326	1.695910e-01	0.771	0	0
DAP12 interactions	R-HSA-2172127	1.529496e-01	0.815	0	0
Formation of paraxial mesoderm	R-HSA-9793380	2.259352e-01	0.646	0	0
HCMV Late Events	R-HSA-9610379	1.323594e-01	0.878	0	0
Downstream TCR signaling	R-HSA-202424	1.536448e-01	0.813	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.489483e-01	0.827	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	2.132652e-01	0.671	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	1.437057e-01	0.843	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.315827e-01	0.881	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	1.826531e-01	0.738	0	0
Formation of definitive endoderm	R-HSA-9823730	1.683842e-01	0.774	0	0
Calnexin/calreticulin cycle	R-HSA-901042	1.579279e-01	0.802	0	0
ABC transporter disorders	R-HSA-5619084	2.095190e-01	0.679	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	1.899376e-01	0.721	0	0
ABC-family proteins mediated transport	R-HSA-382556	1.536185e-01	0.814	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.899376e-01	0.721	0	0
Cellular response to chemical stress	R-HSA-9711123	1.404195e-01	0.853	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.833714e-01	0.737	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	1.485779e-01	0.828	0	0
G1/S-Specific Transcription	R-HSA-69205	1.903629e-01	0.720	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.286922e-01	0.890	0	0
Glycogen synthesis	R-HSA-3322077	1.683842e-01	0.774	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	1.550090e-01	0.810	0	0
NF-kB is activated and signals survival	R-HSA-209560	1.833714e-01	0.737	0	0
Regulation of gene expression in beta cells	R-HSA-210745	1.511008e-01	0.821	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	2.097204e-01	0.678	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	1.899376e-01	0.721	0	0
p75NTR signals via NF-kB	R-HSA-193639	1.529360e-01	0.815	0	0
Glycogen storage diseases	R-HSA-3229121	2.277978e-01	0.642	0	0
Gap junction assembly	R-HSA-190861	1.579279e-01	0.802	0	0
Tie2 Signaling	R-HSA-210993	1.286922e-01	0.890	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	2.548245e-01	0.594	0	0
IRS-mediated signalling	R-HSA-112399	2.578877e-01	0.589	0	0
Interleukin receptor SHC signaling	R-HSA-912526	2.600361e-01	0.585	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.600361e-01	0.585	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	2.614905e-01	0.583	0	0
ARMS-mediated activation	R-HSA-170984	2.616962e-01	0.582	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.616962e-01	0.582	0	0
Interleukin-21 signaling	R-HSA-9020958	2.616962e-01	0.582	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	2.616962e-01	0.582	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	2.616962e-01	0.582	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	2.616962e-01	0.582	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	2.616962e-01	0.582	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	2.616962e-01	0.582	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.626321e-01	0.581	0	0
Interleukin-2 family signaling	R-HSA-451927	2.626321e-01	0.581	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	2.626321e-01	0.581	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	2.630562e-01	0.580	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	2.630562e-01	0.580	0	0
Nuclear import of Rev protein	R-HSA-180746	2.630562e-01	0.580	0	0
Signal amplification	R-HSA-392518	2.630562e-01	0.580	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.645427e-01	0.578	0	0
Signaling by FGFR	R-HSA-190236	2.645951e-01	0.577	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.656244e-01	0.576	0	0
Insulin receptor signalling cascade	R-HSA-74751	2.710534e-01	0.567	0	0
Ion transport by P-type ATPases	R-HSA-936837	2.710534e-01	0.567	0	0
RSV-host interactions	R-HSA-9833110	2.731977e-01	0.564	0	0
Circadian clock	R-HSA-9909396	2.762360e-01	0.559	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.764139e-01	0.558	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.764139e-01	0.558	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	2.764139e-01	0.558	0	0
Physiological factors	R-HSA-5578768	2.764139e-01	0.558	0	0
Zinc transporters	R-HSA-435354	2.764139e-01	0.558	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.764867e-01	0.558	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	2.764867e-01	0.558	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.764867e-01	0.558	0	0
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	2.764867e-01	0.558	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.764867e-01	0.558	0	0
Pyrophosphate hydrolysis	R-HSA-71737	2.764867e-01	0.558	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	2.764867e-01	0.558	0	0
Assembly of Viral Components at the Budding Site	R-HSA-168316	2.764867e-01	0.558	0	0
Signaling by TGFBR3	R-HSA-9839373	2.795777e-01	0.553	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.819270e-01	0.550	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.819270e-01	0.550	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	2.819270e-01	0.550	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	2.829390e-01	0.548	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	2.837949e-01	0.547	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	2.837949e-01	0.547	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	2.847936e-01	0.545	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	2.847936e-01	0.545	0	0
snRNP Assembly	R-HSA-191859	2.905259e-01	0.537	0	0
Metabolism of non-coding RNA	R-HSA-194441	2.905259e-01	0.537	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	2.980153e-01	0.526	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	3.013916e-01	0.521	0	0
Signal attenuation	R-HSA-74749	3.013916e-01	0.521	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	3.049351e-01	0.516	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	3.078528e-01	0.512	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	3.090677e-01	0.510	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	3.090677e-01	0.510	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	3.090677e-01	0.510	0	0
Tight junction interactions	R-HSA-420029	3.100304e-01	0.509	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.108634e-01	0.507	0	0
GPER1 signaling	R-HSA-9634597	3.167530e-01	0.499	0	0
Gluconeogenesis	R-HSA-70263	3.167530e-01	0.499	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	3.188491e-01	0.496	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	3.215769e-01	0.493	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	3.215769e-01	0.493	0	0
MAP kinase activation	R-HSA-450294	3.242733e-01	0.489	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	3.264011e-01	0.486	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	3.304742e-01	0.481	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	3.304742e-01	0.481	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.304742e-01	0.481	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	3.304742e-01	0.481	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	3.304742e-01	0.481	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	3.304742e-01	0.481	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.304742e-01	0.481	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	3.304742e-01	0.481	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.356175e-01	0.474	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	3.356175e-01	0.474	0	0
DNA Damage Bypass	R-HSA-73893	3.357399e-01	0.474	0	0
Cardiac conduction	R-HSA-5576891	3.378859e-01	0.471	0	0
G-protein activation	R-HSA-202040	3.395075e-01	0.469	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	3.395075e-01	0.469	0	0
Neuronal System	R-HSA-112316	3.400737e-01	0.468	0	0
Signaling by Insulin receptor	R-HSA-74752	3.410181e-01	0.467	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	3.413438e-01	0.467	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.413438e-01	0.467	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	3.413438e-01	0.467	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	3.413438e-01	0.467	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	3.413438e-01	0.467	0	0
LGI-ADAM interactions	R-HSA-5682910	3.413438e-01	0.467	0	0
Bicarbonate transporters	R-HSA-425381	3.413438e-01	0.467	0	0
Signaling by APC mutants	R-HSA-4839744	3.413438e-01	0.467	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	3.414713e-01	0.467	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	3.420637e-01	0.466	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	3.420637e-01	0.466	0	0
Regulation of BACH1 activity	R-HSA-9708530	3.420637e-01	0.466	0	0
Iron uptake and transport	R-HSA-917937	3.450958e-01	0.462	0	0
Disease	R-HSA-1643685	3.473781e-01	0.459	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	3.481171e-01	0.458	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.481171e-01	0.458	0	0
Regulation of insulin secretion	R-HSA-422356	3.487676e-01	0.457	0	0
Nuclear RNA decay	R-HSA-9930044	3.546643e-01	0.450	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.546643e-01	0.450	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	3.549251e-01	0.450	0	0
PI and PC transport between ER and Golgi membranes	R-HSA-1483196	3.578144e-01	0.446	0	0
Mitochondrial transcription initiation	R-HSA-163282	3.578144e-01	0.446	0	0
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	3.578144e-01	0.446	0	0
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	3.578144e-01	0.446	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	3.578144e-01	0.446	0	0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	3.578144e-01	0.446	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	3.578144e-01	0.446	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	3.578144e-01	0.446	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	3.578144e-01	0.446	0	0
Defective TPMT causes TPMT deficiency	R-HSA-5578995	3.578144e-01	0.446	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	3.578144e-01	0.446	0	0
TRAF3 deficiency - HSE	R-HSA-5602571	3.578144e-01	0.446	0	0
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	3.578144e-01	0.446	0	0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	3.578144e-01	0.446	0	0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	3.578144e-01	0.446	0	0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.578144e-01	0.446	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.578144e-01	0.446	0	0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	3.578144e-01	0.446	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.578144e-01	0.446	0	0
Signaling by kinase domain mutants of KIT	R-HSA-9669933	3.578144e-01	0.446	0	0
Defective APRT disrupts adenine salvage	R-HSA-9734195	3.578144e-01	0.446	0	0
Nef mediated downregulation of CD28 cell surface expression	R-HSA-164939	3.578144e-01	0.446	0	0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	3.578144e-01	0.446	0	0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	3.578144e-01	0.446	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.578144e-01	0.446	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	3.614293e-01	0.442	0	0
Insulin processing	R-HSA-264876	3.614293e-01	0.442	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	3.683338e-01	0.434	0	0
Attachment and Entry	R-HSA-9694614	3.683338e-01	0.434	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	3.700084e-01	0.432	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	3.700084e-01	0.432	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.751427e-01	0.426	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	3.751427e-01	0.426	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.751427e-01	0.426	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.751427e-01	0.426	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.751427e-01	0.426	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	3.751427e-01	0.426	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	3.751427e-01	0.426	0	0
Interleukin-1 family signaling	R-HSA-446652	3.774506e-01	0.423	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	3.783408e-01	0.422	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	3.811137e-01	0.419	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	3.811137e-01	0.419	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	3.811137e-01	0.419	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	3.811137e-01	0.419	0	0
PI3K events in ERBB4 signaling	R-HSA-1250342	3.811137e-01	0.419	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	3.811137e-01	0.419	0	0
Signaling by AXIN mutants	R-HSA-4839735	3.811137e-01	0.419	0	0
Toll-like Receptor Cascades	R-HSA-168898	3.826452e-01	0.417	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.827840e-01	0.417	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	3.827840e-01	0.417	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.832762e-01	0.416	0	0
Autointegration results in viral DNA circles	R-HSA-177539	3.832762e-01	0.416	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.832762e-01	0.416	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	3.832762e-01	0.416	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.832762e-01	0.416	0	0
CREB phosphorylation	R-HSA-199920	3.832762e-01	0.416	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.832762e-01	0.416	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	3.832762e-01	0.416	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.873444e-01	0.412	0	0
HIV elongation arrest and recovery	R-HSA-167287	3.873444e-01	0.412	0	0
Formation of the Early Elongation Complex	R-HSA-113418	3.873444e-01	0.412	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	3.873444e-01	0.412	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.873444e-01	0.412	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	3.873444e-01	0.412	0	0
Pyroptosis	R-HSA-5620971	3.873444e-01	0.412	0	0
Inflammasomes	R-HSA-622312	3.873444e-01	0.412	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	3.909451e-01	0.408	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	3.920017e-01	0.407	0	0
HIV Transcription Elongation	R-HSA-167169	3.920017e-01	0.407	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	3.920017e-01	0.407	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.920017e-01	0.407	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	3.936876e-01	0.405	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	3.971784e-01	0.401	0	0
Notch-HLH transcription pathway	R-HSA-350054	3.971784e-01	0.401	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	3.971784e-01	0.401	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.971784e-01	0.401	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	3.971784e-01	0.401	0	0
LDL clearance	R-HSA-8964038	3.971784e-01	0.401	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	3.971784e-01	0.401	0	0
Mitophagy	R-HSA-5205647	4.020760e-01	0.396	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.021447e-01	0.396	0	0
Regulation of beta-cell development	R-HSA-186712	4.031746e-01	0.395	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	4.080684e-01	0.389	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.080684e-01	0.389	0	0
Specification of primordial germ cells	R-HSA-9827857	4.080684e-01	0.389	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	4.081554e-01	0.389	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	4.108564e-01	0.386	0	0
mRNA Capping	R-HSA-72086	4.132473e-01	0.384	0	0
DARPP-32 events	R-HSA-180024	4.132473e-01	0.384	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	4.163365e-01	0.381	0	0
Gastrulation	R-HSA-9758941	4.192219e-01	0.378	0	0
Polymerase switching	R-HSA-69091	4.203260e-01	0.376	0	0
Leading Strand Synthesis	R-HSA-69109	4.203260e-01	0.376	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	4.203260e-01	0.376	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	4.203260e-01	0.376	0	0
Interleukin-15 signaling	R-HSA-8983432	4.203260e-01	0.376	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.203260e-01	0.376	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.203260e-01	0.376	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	4.203260e-01	0.376	0	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	4.203260e-01	0.376	0	0
OAS antiviral response	R-HSA-8983711	4.203260e-01	0.376	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	4.247054e-01	0.372	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	4.257827e-01	0.371	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	4.258887e-01	0.371	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	4.258887e-01	0.371	0	0
Interleukin-20 family signaling	R-HSA-8854691	4.258887e-01	0.371	0	0
MECP2 regulates transcription factors	R-HSA-9022707	4.342012e-01	0.362	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	4.342012e-01	0.362	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	4.342012e-01	0.362	0	0
Disinhibition of SNARE formation	R-HSA-114516	4.342012e-01	0.362	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.342012e-01	0.362	0	0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	4.342012e-01	0.362	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	4.342012e-01	0.362	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.342012e-01	0.362	0	0
CHL1 interactions	R-HSA-447041	4.342012e-01	0.362	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	4.342012e-01	0.362	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	4.342012e-01	0.362	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	4.390292e-01	0.358	0	0
Polo-like kinase mediated events	R-HSA-156711	4.406292e-01	0.356	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.406292e-01	0.356	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	4.406292e-01	0.356	0	0
Mismatch Repair	R-HSA-5358508	4.406292e-01	0.356	0	0
PKA activation	R-HSA-163615	4.406292e-01	0.356	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	4.406292e-01	0.356	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	4.406292e-01	0.356	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	4.429700e-01	0.354	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	4.429700e-01	0.354	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	4.429700e-01	0.354	0	0
NGF-stimulated transcription	R-HSA-9031628	4.446330e-01	0.352	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	4.459622e-01	0.351	0	0
NTF4 activates NTRK2 (TRKB) signaling	R-HSA-9026357	4.459622e-01	0.351	0	0
NTF3 activates NTRK2 (TRKB) signaling	R-HSA-9025046	4.459622e-01	0.351	0	0
BDNF activates NTRK2 (TRKB) signaling	R-HSA-9024909	4.459622e-01	0.351	0	0
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	4.459622e-01	0.351	0	0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	4.459622e-01	0.351	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.459622e-01	0.351	0	0
Defective AHCY causes HMAHCHD	R-HSA-5578997	4.459622e-01	0.351	0	0
Glycogen storage disease type IV (GBE1)	R-HSA-3878781	4.459622e-01	0.351	0	0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	4.459622e-01	0.351	0	0
Transcription from mitochondrial promoters	R-HSA-75944	4.459622e-01	0.351	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	4.459622e-01	0.351	0	0
Interleukin-33 signaling	R-HSA-9014843	4.459622e-01	0.351	0	0
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	4.459622e-01	0.351	0	0
Diseases of Cellular Senescence	R-HSA-9630747	4.459622e-01	0.351	0	0
Diseases of cellular response to stress	R-HSA-9675132	4.459622e-01	0.351	0	0
DSCAM interactions	R-HSA-376172	4.459622e-01	0.351	0	0
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	4.459622e-01	0.351	0	0
Transcription of the HIV genome	R-HSA-167172	4.468638e-01	0.350	0	0
G alpha (z) signalling events	R-HSA-418597	4.520745e-01	0.345	0	0
Interleukin-6 family signaling	R-HSA-6783589	4.543244e-01	0.343	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	4.578958e-01	0.339	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	4.586668e-01	0.339	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	4.586668e-01	0.339	0	0
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	4.586668e-01	0.339	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	4.586668e-01	0.339	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	4.645887e-01	0.333	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	4.645887e-01	0.333	0	0
Inositol phosphate metabolism	R-HSA-1483249	4.662863e-01	0.331	0	0
Rab regulation of trafficking	R-HSA-9007101	4.702142e-01	0.328	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.726381e-01	0.325	0	0
Germ layer formation at gastrulation	R-HSA-9754189	4.726381e-01	0.325	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	4.726381e-01	0.325	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	4.745496e-01	0.324	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.801020e-01	0.319	0	0
Interleukin-17 signaling	R-HSA-448424	4.819726e-01	0.317	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	4.823589e-01	0.317	0	0
G protein gated Potassium channels	R-HSA-1296059	4.823589e-01	0.317	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	4.823589e-01	0.317	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	4.823589e-01	0.317	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	4.827701e-01	0.316	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	4.827701e-01	0.316	0	0
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	4.827701e-01	0.316	0	0
Adrenoceptors	R-HSA-390696	4.827701e-01	0.316	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	4.827701e-01	0.316	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.827701e-01	0.316	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	4.830820e-01	0.316	0	0
Signaling by WNT in cancer	R-HSA-4791275	4.898327e-01	0.310	0	0
Integration of energy metabolism	R-HSA-163685	4.932744e-01	0.307	0	0
Prolactin receptor signaling	R-HSA-1170546	4.958801e-01	0.305	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	4.958801e-01	0.305	0	0
CRMPs in Sema3A signaling	R-HSA-399956	4.958801e-01	0.305	0	0
Malate-aspartate shuttle	R-HSA-9856872	4.958801e-01	0.305	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	4.959324e-01	0.305	0	0
Protein hydroxylation	R-HSA-9629569	5.039337e-01	0.298	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	5.096525e-01	0.293	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	5.098788e-01	0.293	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	5.098788e-01	0.293	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	5.098788e-01	0.293	1	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	5.098788e-01	0.293	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.146763e-01	0.288	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	5.146763e-01	0.288	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	5.146763e-01	0.288	0	0
Signaling by ALK	R-HSA-201556	5.187516e-01	0.285	0	0
Innate Immune System	R-HSA-168249	5.188323e-01	0.285	0	0
PLC-gamma1 signalling	R-HSA-167021	5.220150e-01	0.282	0	0
Activated NTRK3 signals through PLCG1	R-HSA-9034793	5.220150e-01	0.282	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	5.220150e-01	0.282	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.220150e-01	0.282	0	0
Signalling to STAT3	R-HSA-198745	5.220150e-01	0.282	0	0
Invadopodia formation	R-HSA-8941237	5.220150e-01	0.282	0	0
Classical Kir channels	R-HSA-1296053	5.220150e-01	0.282	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.220150e-01	0.282	0	0
STAT6-mediated induction of chemokines	R-HSA-3249367	5.220150e-01	0.282	0	0
Intracellular oxygen transport	R-HSA-8981607	5.220150e-01	0.282	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.220150e-01	0.282	0	0
FasL/ CD95L signaling	R-HSA-75157	5.220150e-01	0.282	0	0
Lipophagy	R-HSA-9613354	5.286702e-01	0.277	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	5.286702e-01	0.277	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	5.286702e-01	0.277	0	0
p75NTR regulates axonogenesis	R-HSA-193697	5.286702e-01	0.277	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	5.286702e-01	0.277	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	5.286702e-01	0.277	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	5.286702e-01	0.277	1	1
Processive synthesis on the lagging strand	R-HSA-69183	5.317630e-01	0.274	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.317630e-01	0.274	0	0
DNA Damage Reversal	R-HSA-73942	5.317630e-01	0.274	0	0
Formation of the anterior neural plate	R-HSA-9823739	5.317630e-01	0.274	0	0
Lagging Strand Synthesis	R-HSA-69186	5.343789e-01	0.272	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	5.343789e-01	0.272	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	5.343789e-01	0.272	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	5.343789e-01	0.272	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	5.343789e-01	0.272	0	0
Interferon gamma signaling	R-HSA-877300	5.364766e-01	0.270	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.367847e-01	0.270	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	5.367847e-01	0.270	0	0
Cristae formation	R-HSA-8949613	5.367847e-01	0.270	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	5.367847e-01	0.270	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.367847e-01	0.270	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	5.367847e-01	0.270	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.390432e-01	0.268	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	5.390432e-01	0.268	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	5.390432e-01	0.268	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	5.390432e-01	0.268	0	0
Leishmania phagocytosis	R-HSA-9664417	5.426649e-01	0.265	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	5.426649e-01	0.265	0	0
Parasite infection	R-HSA-9664407	5.426649e-01	0.265	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	5.432210e-01	0.265	0	0
tRNA Aminoacylation	R-HSA-379724	5.470433e-01	0.262	0	0
eNOS activation	R-HSA-203615	5.628659e-01	0.250	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	5.628659e-01	0.250	0	0
Insulin receptor recycling	R-HSA-77387	5.629904e-01	0.249	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.629904e-01	0.249	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	5.629904e-01	0.249	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	5.637410e-01	0.249	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	5.638601e-01	0.249	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	5.638601e-01	0.249	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	5.638601e-01	0.249	0	0
Aquaporin-mediated transport	R-HSA-445717	5.653335e-01	0.248	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	5.661608e-01	0.247	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.661608e-01	0.247	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.661608e-01	0.247	0	0
Activation of SMO	R-HSA-5635838	5.661608e-01	0.247	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	5.661608e-01	0.247	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	5.661608e-01	0.247	0	0
Binding and entry of HIV virion	R-HSA-173107	5.717191e-01	0.243	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	5.717191e-01	0.243	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	5.717191e-01	0.243	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	5.717191e-01	0.243	0	0
Maturation of spike protein	R-HSA-9683686	5.717191e-01	0.243	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	5.717191e-01	0.243	0	0
Intraflagellar transport	R-HSA-5620924	5.838480e-01	0.234	0	0
Translation of Structural Proteins	R-HSA-9683701	5.846683e-01	0.233	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.860855e-01	0.232	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	5.876043e-01	0.231	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	5.876043e-01	0.231	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.876318e-01	0.231	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	5.876318e-01	0.231	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	5.876318e-01	0.231	0	0
Signaling by MAP2K mutants	R-HSA-9652169	5.876318e-01	0.231	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	5.876318e-01	0.231	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.876318e-01	0.231	0	0
Regulation of gap junction activity	R-HSA-191650	5.876318e-01	0.231	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	5.876318e-01	0.231	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	5.876318e-01	0.231	0	0
Dopamine receptors	R-HSA-390651	5.876318e-01	0.231	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	5.876318e-01	0.231	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	5.876318e-01	0.231	0	0
NADE modulates death signalling	R-HSA-205025	5.876318e-01	0.231	0	0
Sensory perception of sour taste	R-HSA-9729555	5.876318e-01	0.231	0	0
Electric Transmission Across Gap Junctions	R-HSA-112303	5.876318e-01	0.231	0	0
Transmission across Electrical Synapses	R-HSA-112307	5.876318e-01	0.231	0	0
Toxicity of tetanus toxin (tetX)	R-HSA-5250982	5.876318e-01	0.231	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.884231e-01	0.230	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	5.884231e-01	0.230	0	0
Glucagon-type ligand receptors	R-HSA-420092	5.884231e-01	0.230	0	0
FGFR2 alternative splicing	R-HSA-6803529	5.922857e-01	0.227	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.922857e-01	0.227	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	5.922857e-01	0.227	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	5.989613e-01	0.223	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	5.989613e-01	0.223	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	5.989613e-01	0.223	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.989613e-01	0.223	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.009514e-01	0.221	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	6.028628e-01	0.220	0	0
Activation of GABAB receptors	R-HSA-991365	6.056311e-01	0.218	0	0
GABA B receptor activation	R-HSA-977444	6.056311e-01	0.218	0	0
Parasitic Infection Pathways	R-HSA-9824443	6.064378e-01	0.217	0	0
Leishmania infection	R-HSA-9658195	6.064378e-01	0.217	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	6.118347e-01	0.213	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	6.118347e-01	0.213	0	0
Formation of the posterior neural plate	R-HSA-9832991	6.118347e-01	0.213	0	0
vRNP Assembly	R-HSA-192905	6.118347e-01	0.213	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	6.118347e-01	0.213	0	0
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	6.118347e-01	0.213	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	6.118347e-01	0.213	0	0
Dissolution of Fibrin Clot	R-HSA-75205	6.118347e-01	0.213	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	6.130225e-01	0.213	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	6.130225e-01	0.213	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	6.130225e-01	0.213	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	6.130225e-01	0.213	0	0
Interleukin-37 signaling	R-HSA-9008059	6.130225e-01	0.213	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	6.156224e-01	0.211	0	0
Integrin cell surface interactions	R-HSA-216083	6.156224e-01	0.211	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	6.195846e-01	0.208	0	0
PI3K Cascade	R-HSA-109704	6.226807e-01	0.206	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.256436e-01	0.204	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.256436e-01	0.204	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	6.260228e-01	0.203	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.300897e-01	0.201	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	6.300897e-01	0.201	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.300897e-01	0.201	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.300897e-01	0.201	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.300897e-01	0.201	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.300897e-01	0.201	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	6.300897e-01	0.201	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	6.329182e-01	0.199	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.427790e-01	0.192	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	6.442441e-01	0.191	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	6.442441e-01	0.191	0	0
G2 Phase	R-HSA-68911	6.442441e-01	0.191	0	0
NTRK2 activates RAC1	R-HSA-9032759	6.442441e-01	0.191	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	6.442441e-01	0.191	0	0
PTK6 Activates STAT3	R-HSA-8849474	6.442441e-01	0.191	0	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	6.442441e-01	0.191	0	0
PTK6 Down-Regulation	R-HSA-8849472	6.442441e-01	0.191	0	0
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	6.442441e-01	0.191	0	0
Reelin signalling pathway	R-HSA-8866376	6.442441e-01	0.191	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	6.442441e-01	0.191	0	0
Interleukin-36 pathway	R-HSA-9014826	6.442441e-01	0.191	0	0
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	6.442441e-01	0.191	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	6.442441e-01	0.191	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.444050e-01	0.191	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	6.457045e-01	0.190	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	6.457045e-01	0.190	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	6.457045e-01	0.190	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	6.457045e-01	0.190	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	6.457045e-01	0.190	0	0
Proton-coupled monocarboxylate transport	R-HSA-433692	6.490109e-01	0.188	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	6.490109e-01	0.188	0	0
ERKs are inactivated	R-HSA-202670	6.490109e-01	0.188	0	0
Sodium/Calcium exchangers	R-HSA-425561	6.490109e-01	0.188	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.516596e-01	0.186	0	0
Extension of Telomeres	R-HSA-180786	6.551150e-01	0.184	0	0
PKA activation in glucagon signalling	R-HSA-164378	6.595031e-01	0.181	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	6.595394e-01	0.181	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	6.595394e-01	0.181	0	0
Fanconi Anemia Pathway	R-HSA-6783310	6.649733e-01	0.177	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.706101e-01	0.174	0	0
Metabolism of polyamines	R-HSA-351202	6.718837e-01	0.173	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.720402e-01	0.173	0	0
Amino acids regulate mTORC1	R-HSA-9639288	6.770570e-01	0.169	0	0
Cardiogenesis	R-HSA-9733709	6.813927e-01	0.167	0	0
Repression of WNT target genes	R-HSA-4641265	6.832987e-01	0.165	0	0
Scavenging by Class F Receptors	R-HSA-3000484	6.832987e-01	0.165	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	6.834857e-01	0.165	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	6.834857e-01	0.165	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	6.871861e-01	0.163	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.871861e-01	0.163	0	0
Specification of the neural plate border	R-HSA-9834899	6.871861e-01	0.163	0	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	6.871861e-01	0.163	0	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	6.871861e-01	0.163	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	6.871861e-01	0.163	0	0
NGF-independant TRKA activation	R-HSA-187024	6.930871e-01	0.159	0	0
Plus-strand DNA synthesis	R-HSA-164525	6.930871e-01	0.159	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.930871e-01	0.159	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.930871e-01	0.159	0	0
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	6.930871e-01	0.159	0	0
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	6.930871e-01	0.159	0	0
Signaling by MST1	R-HSA-8852405	6.930871e-01	0.159	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	6.930871e-01	0.159	0	0
Pentose phosphate pathway disease	R-HSA-6791465	6.930871e-01	0.159	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	6.930871e-01	0.159	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.930871e-01	0.159	0	0
Cam-PDE 1 activation	R-HSA-111957	6.930871e-01	0.159	0	0
Formation of the Editosome	R-HSA-75094	6.930871e-01	0.159	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	6.930871e-01	0.159	0	0
Intestinal hexose absorption	R-HSA-8981373	6.930871e-01	0.159	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	6.930871e-01	0.159	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.930871e-01	0.159	0	0
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	6.930871e-01	0.159	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.930871e-01	0.159	0	0
TRAIL signaling	R-HSA-75158	6.930871e-01	0.159	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.930871e-01	0.159	0	0
PI Metabolism	R-HSA-1483255	6.936785e-01	0.159	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	6.942810e-01	0.158	0	0
Suppression of phagosomal maturation	R-HSA-9637687	6.942810e-01	0.158	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	7.020451e-01	0.154	0	0
Miscellaneous transport and binding events	R-HSA-5223345	7.022829e-01	0.153	0	0
Heme signaling	R-HSA-9707616	7.039208e-01	0.152	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	7.104517e-01	0.148	0	0
Interferon alpha/beta signaling	R-HSA-909733	7.121370e-01	0.147	0	0
Ion channel transport	R-HSA-983712	7.129942e-01	0.147	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	7.131459e-01	0.147	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.131459e-01	0.147	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.131459e-01	0.147	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.131459e-01	0.147	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.131459e-01	0.147	0	0
Creatine metabolism	R-HSA-71288	7.131459e-01	0.147	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.131459e-01	0.147	0	0
Formation of axial mesoderm	R-HSA-9796292	7.147904e-01	0.146	0	0
Processing of SMDT1	R-HSA-8949664	7.147904e-01	0.146	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	7.167104e-01	0.145	0	0
Metal ion SLC transporters	R-HSA-425410	7.185064e-01	0.144	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.222010e-01	0.141	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.222010e-01	0.141	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.284606e-01	0.138	0	0
Mitochondrial biogenesis	R-HSA-1592230	7.343058e-01	0.134	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	7.352124e-01	0.134	0	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	7.352268e-01	0.134	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	7.352268e-01	0.134	0	0
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	R-HSA-3656244	7.352268e-01	0.134	0	0
STAT5 Activation	R-HSA-9645135	7.352268e-01	0.134	0	0
Uncoating of the HIV Virion	R-HSA-162585	7.352268e-01	0.134	0	0
Metabolism of ingested MeSeO2H into MeSeH	R-HSA-5263617	7.352268e-01	0.134	0	0
G2/M DNA replication checkpoint	R-HSA-69478	7.352268e-01	0.134	0	0
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	7.352268e-01	0.134	0	0
Defective CHST6 causes MCDC1	R-HSA-3656225	7.352268e-01	0.134	0	0
Defective ST3GAL3 causes MCT12 and EIEE15	R-HSA-3656243	7.352268e-01	0.134	0	0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	7.352268e-01	0.134	0	0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	7.352268e-01	0.134	0	0
MET Receptor Activation	R-HSA-6806942	7.352268e-01	0.134	0	0
Lactose synthesis	R-HSA-5653890	7.352268e-01	0.134	0	0
VLDL assembly	R-HSA-8866423	7.352268e-01	0.134	0	0
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	7.352268e-01	0.134	0	0
HDL clearance	R-HSA-8964011	7.352268e-01	0.134	0	0
Leukotriene receptors	R-HSA-391906	7.352268e-01	0.134	0	0
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	7.352268e-01	0.134	0	0
Neurofascin interactions	R-HSA-447043	7.352268e-01	0.134	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.374084e-01	0.132	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.374084e-01	0.132	0	0
ERK/MAPK targets	R-HSA-198753	7.374084e-01	0.132	0	0
Telomere Extension By Telomerase	R-HSA-171319	7.379027e-01	0.132	0	0
Removal of the Flap Intermediate	R-HSA-69166	7.436073e-01	0.129	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	7.436073e-01	0.129	0	0
Signal regulatory protein family interactions	R-HSA-391160	7.436073e-01	0.129	0	0
HDL assembly	R-HSA-8963896	7.436073e-01	0.129	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	7.497679e-01	0.125	0	0
Azathioprine ADME	R-HSA-9748787	7.508023e-01	0.124	0	0
Pyruvate metabolism	R-HSA-70268	7.548727e-01	0.122	0	0
RUNX2 regulates bone development	R-HSA-8941326	7.591230e-01	0.120	0	0
Triglyceride catabolism	R-HSA-163560	7.591230e-01	0.120	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.600147e-01	0.119	0	0
TBC/RABGAPs	R-HSA-8854214	7.620705e-01	0.118	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	7.698902e-01	0.114	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	7.698902e-01	0.114	0	0
Protein lipoylation	R-HSA-9857492	7.698902e-01	0.114	0	0
Other semaphorin interactions	R-HSA-416700	7.698902e-01	0.114	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	7.715827e-01	0.113	0	0
Netrin mediated repulsion signals	R-HSA-418886	7.715827e-01	0.113	0	0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	7.715827e-01	0.113	0	0
DAG1 core M1 glycosylations	R-HSA-8932506	7.715827e-01	0.113	0	0
Recycling of eIF2:GDP	R-HSA-72731	7.715827e-01	0.113	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.715827e-01	0.113	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	7.715827e-01	0.113	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	7.715827e-01	0.113	0	0
Activation of TRKA receptors	R-HSA-187015	7.715827e-01	0.113	0	0
LDL remodeling	R-HSA-8964041	7.715827e-01	0.113	0	0
VLDL clearance	R-HSA-8964046	7.715827e-01	0.113	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	7.715827e-01	0.113	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	7.715827e-01	0.113	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.796036e-01	0.108	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	7.803649e-01	0.108	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	7.810177e-01	0.107	0	0
Cellular hexose transport	R-HSA-189200	7.810177e-01	0.107	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	7.810177e-01	0.107	0	0
Cytoprotection by HMOX1	R-HSA-9707564	7.843694e-01	0.105	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	7.922255e-01	0.101	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.925057e-01	0.101	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	7.937915e-01	0.100	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	7.937915e-01	0.100	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	7.937915e-01	0.100	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	7.937915e-01	0.100	0	0
Attachment and Entry	R-HSA-9678110	7.937915e-01	0.100	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	7.937915e-01	0.100	0	0
Differentiation of T cells	R-HSA-9945266	7.937915e-01	0.100	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	7.937915e-01	0.100	0	0
Atorvastatin ADME	R-HSA-9754706	7.937915e-01	0.100	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	7.937915e-01	0.100	0	0
Virus Assembly and Release	R-HSA-168268	7.937915e-01	0.100	0	0
Molecules associated with elastic fibres	R-HSA-2129379	7.942436e-01	0.100	0	0
Reverse Transcription of HIV RNA	R-HSA-162589	8.029484e-01	0.095	0	0
Minus-strand DNA synthesis	R-HSA-164516	8.029484e-01	0.095	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	8.029484e-01	0.095	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	8.029484e-01	0.095	0	0
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	8.029484e-01	0.095	0	0
Regulation by c-FLIP	R-HSA-3371378	8.029484e-01	0.095	0	0
phospho-PLA2 pathway	R-HSA-111995	8.029484e-01	0.095	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	8.029484e-01	0.095	0	0
Dimerization of procaspase-8	R-HSA-69416	8.029484e-01	0.095	0	0
DAG1 core M2 glycosylations	R-HSA-8932504	8.029484e-01	0.095	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	8.029484e-01	0.095	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	8.029484e-01	0.095	0	0
Fructose biosynthesis	R-HSA-5652227	8.029484e-01	0.095	0	0
Nucleotide salvage defects	R-HSA-9734207	8.029484e-01	0.095	0	0
TGFBR3 PTM regulation	R-HSA-9839383	8.029484e-01	0.095	0	0
Sodium/Proton exchangers	R-HSA-425986	8.029484e-01	0.095	0	0
Intestinal absorption	R-HSA-8963676	8.029484e-01	0.095	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.065606e-01	0.093	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.065606e-01	0.093	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	8.065606e-01	0.093	0	0
Diseases of DNA repair	R-HSA-9675135	8.065606e-01	0.093	0	0
Pentose phosphate pathway	R-HSA-71336	8.073886e-01	0.093	0	0
tRNA processing in the nucleus	R-HSA-6784531	8.088685e-01	0.092	0	0
Post-translational protein phosphorylation	R-HSA-8957275	8.136436e-01	0.090	0	0
Galactose catabolism	R-HSA-70370	8.154696e-01	0.089	0	0
Passive transport by Aquaporins	R-HSA-432047	8.154696e-01	0.089	0	0
Response to metal ions	R-HSA-5660526	8.154696e-01	0.089	0	0
Complex III assembly	R-HSA-9865881	8.184679e-01	0.087	0	0
Plasma lipoprotein assembly	R-HSA-8963898	8.184679e-01	0.087	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.201484e-01	0.086	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.207226e-01	0.086	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.216579e-01	0.085	0	0
Diseases of Immune System	R-HSA-5260271	8.216579e-01	0.085	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.216579e-01	0.085	0	0
FOXO-mediated transcription	R-HSA-9614085	8.230142e-01	0.085	0	0
CASP8 activity is inhibited	R-HSA-5218900	8.300086e-01	0.081	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	8.300086e-01	0.081	0	0
Regulation of signaling by NODAL	R-HSA-1433617	8.300086e-01	0.081	0	0
WNT mediated activation of DVL	R-HSA-201688	8.300086e-01	0.081	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	8.300086e-01	0.081	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	8.300086e-01	0.081	0	0
mRNA Editing	R-HSA-75072	8.300086e-01	0.081	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	8.300086e-01	0.081	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	8.300086e-01	0.081	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.315096e-01	0.080	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	8.350568e-01	0.078	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	8.350568e-01	0.078	0	0
Laminin interactions	R-HSA-3000157	8.350568e-01	0.078	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.350568e-01	0.078	0	0
Formation of the nephric duct	R-HSA-9830364	8.350568e-01	0.078	0	0
Hyaluronan degradation	R-HSA-2160916	8.350568e-01	0.078	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.350568e-01	0.078	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.350843e-01	0.078	0	0
GDP-fucose biosynthesis	R-HSA-6787639	8.350843e-01	0.078	0	0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	8.350843e-01	0.078	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	8.350843e-01	0.078	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	8.404054e-01	0.076	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.438041e-01	0.074	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.476286e-01	0.072	0	0
HIV Transcription Initiation	R-HSA-167161	8.476286e-01	0.072	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.476286e-01	0.072	0	0
MET activates PTK2 signaling	R-HSA-8874081	8.503219e-01	0.070	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.503219e-01	0.070	0	0
TRP channels	R-HSA-3295583	8.503219e-01	0.070	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	8.527934e-01	0.069	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	8.527934e-01	0.069	0	0
Nephron development	R-HSA-9831926	8.527934e-01	0.069	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	8.533541e-01	0.069	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	8.533541e-01	0.069	0	0
CASP4 inflammasome assembly	R-HSA-9948001	8.533541e-01	0.069	0	0
Sperm Motility And Taxes	R-HSA-1300642	8.533541e-01	0.069	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.533541e-01	0.069	0	0
Tandem pore domain potassium channels	R-HSA-1296346	8.533541e-01	0.069	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	8.537233e-01	0.069	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.537233e-01	0.069	0	0
Hyaluronan metabolism	R-HSA-2142845	8.537233e-01	0.069	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	8.537233e-01	0.069	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.537233e-01	0.069	0	0
Peroxisomal protein import	R-HSA-9033241	8.633036e-01	0.064	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.633282e-01	0.064	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	8.643403e-01	0.063	0	0
The phototransduction cascade	R-HSA-2514856	8.659388e-01	0.063	0	0
Transferrin endocytosis and recycling	R-HSA-917977	8.660844e-01	0.062	0	0
PERK regulates gene expression	R-HSA-381042	8.660844e-01	0.062	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	8.687502e-01	0.061	0	0
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	8.687502e-01	0.061	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	8.687502e-01	0.061	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	8.693648e-01	0.061	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	8.703851e-01	0.060	0	0
GABA receptor activation	R-HSA-977443	8.727439e-01	0.059	0	0
FCERI mediated MAPK activation	R-HSA-2871796	8.731926e-01	0.059	0	0
DAG1 core M3 glycosylations	R-HSA-8932505	8.734946e-01	0.059	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	8.734946e-01	0.059	0	0
vRNA Synthesis	R-HSA-192814	8.734946e-01	0.059	0	0
Chylomicron assembly	R-HSA-8963888	8.734946e-01	0.059	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.734946e-01	0.059	0	0
Suppression of apoptosis	R-HSA-9635465	8.734946e-01	0.059	0	0
Transport of RCbl within the body	R-HSA-9758890	8.734946e-01	0.059	0	0
Translation of Structural Proteins	R-HSA-9694635	8.783044e-01	0.056	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	8.816383e-01	0.055	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	8.831020e-01	0.054	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	8.831020e-01	0.054	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	8.881313e-01	0.052	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	8.900078e-01	0.051	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.901970e-01	0.051	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.908700e-01	0.050	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	8.908700e-01	0.050	0	0
Plasmalogen biosynthesis	R-HSA-75896	8.908700e-01	0.050	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.908700e-01	0.050	0	0
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	8.908700e-01	0.050	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	8.959885e-01	0.048	0	0
Vitamin C (ascorbate) metabolism	R-HSA-196836	8.959885e-01	0.048	0	0
Elastic fibre formation	R-HSA-1566948	8.979149e-01	0.047	0	0
Stimuli-sensing channels	R-HSA-2672351	8.981395e-01	0.047	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.996836e-01	0.046	0	0
Maple Syrup Urine Disease	R-HSA-9865114	9.058598e-01	0.043	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	9.058598e-01	0.043	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	9.058598e-01	0.043	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.069364e-01	0.042	0	0
Serine metabolism	R-HSA-977347	9.075414e-01	0.042	0	0
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.075414e-01	0.042	0	0
Cargo concentration in the ER	R-HSA-5694530	9.094761e-01	0.041	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.152431e-01	0.038	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.152431e-01	0.038	0	0
Dectin-2 family	R-HSA-5621480	9.163735e-01	0.038	0	0
Neddylation	R-HSA-8951664	9.180009e-01	0.037	0	0
HS-GAG degradation	R-HSA-2024096	9.183927e-01	0.037	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	9.187914e-01	0.037	0	0
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	9.187914e-01	0.037	0	0
Microbial factors inhibit CASP4 activity	R-HSA-9956593	9.187914e-01	0.037	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	9.187914e-01	0.037	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	9.187914e-01	0.037	0	0
Diseases of nucleotide metabolism	R-HSA-9735804	9.187914e-01	0.037	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	9.187914e-01	0.037	0	0
Maturation of nucleoprotein	R-HSA-9683610	9.187914e-01	0.037	0	0
Maturation of spike protein	R-HSA-9694548	9.228809e-01	0.035	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.229368e-01	0.035	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	9.265003e-01	0.033	0	0
Recycling of bile acids and salts	R-HSA-159418	9.265003e-01	0.033	0	0
Metabolism of proteins	R-HSA-392499	9.266670e-01	0.033	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.271304e-01	0.033	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.271304e-01	0.033	0	0
Formation of the ureteric bud	R-HSA-9830674	9.271304e-01	0.033	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.271304e-01	0.033	0	0
Carnitine shuttle	R-HSA-200425	9.271304e-01	0.033	0	0
Triglyceride metabolism	R-HSA-8979227	9.290437e-01	0.032	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.299472e-01	0.032	0	0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	9.299472e-01	0.032	0	0
cGMP effects	R-HSA-418457	9.299472e-01	0.032	0	0
Hydrolysis of LPC	R-HSA-1483115	9.299472e-01	0.032	0	0
Formation of the active cofactor, UDP-glucuronate	R-HSA-173599	9.299472e-01	0.032	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.299472e-01	0.032	0	0
Non-canonical inflammasome activation	R-HSA-9686114	9.299472e-01	0.032	0	0
Acyl chain remodeling of CL	R-HSA-1482798	9.299472e-01	0.032	0	0
Extracellular matrix organization	R-HSA-1474244	9.301011e-01	0.031	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.323218e-01	0.030	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.325632e-01	0.030	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.333253e-01	0.030	0	0
Resolution of D-Loop Structures	R-HSA-5693537	9.338621e-01	0.030	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.353869e-01	0.029	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	9.395711e-01	0.027	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.395711e-01	0.027	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	9.395711e-01	0.027	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	9.395711e-01	0.027	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.413457e-01	0.026	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.427507e-01	0.026	0	0
Acyl chain remodelling of PS	R-HSA-1482801	9.427507e-01	0.026	0	0
Adipogenesis	R-HSA-9843745	9.467569e-01	0.024	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	9.478734e-01	0.023	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	9.478734e-01	0.023	0	0
Activation of the phototransduction cascade	R-HSA-2485179	9.478734e-01	0.023	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.493113e-01	0.023	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.493113e-01	0.023	0	0
Urea cycle	R-HSA-70635	9.493113e-01	0.023	0	0
Sphingolipid catabolism	R-HSA-9845614	9.493113e-01	0.023	0	0
HS-GAG biosynthesis	R-HSA-2022928	9.520553e-01	0.021	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.525314e-01	0.021	0	0
Glycine degradation	R-HSA-6783984	9.550354e-01	0.020	0	0
Fibronectin matrix formation	R-HSA-1566977	9.550354e-01	0.020	0	0
Heme assimilation	R-HSA-9927020	9.550354e-01	0.020	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	9.550354e-01	0.020	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.550354e-01	0.020	0	0
Coenzyme A biosynthesis	R-HSA-196783	9.550354e-01	0.020	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.551504e-01	0.020	0	0
Prednisone ADME	R-HSA-9757110	9.603422e-01	0.018	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.603422e-01	0.018	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.612138e-01	0.017	0	0
Sulfide oxidation to sulfate	R-HSA-1614517	9.612138e-01	0.017	0	0
Choline catabolism	R-HSA-6798163	9.612138e-01	0.017	0	0
Kidney development	R-HSA-9830369	9.643441e-01	0.016	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.654852e-01	0.015	0	0
Protein localization	R-HSA-9609507	9.665225e-01	0.015	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.665246e-01	0.015	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	9.665435e-01	0.015	0	0
Apoptotic factor-mediated response	R-HSA-111471	9.665435e-01	0.015	0	0
G alpha (q) signalling events	R-HSA-416476	9.673652e-01	0.014	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.691106e-01	0.014	0	0
Interleukin-10 signaling	R-HSA-6783783	9.694054e-01	0.013	0	0
Peptide hormone metabolism	R-HSA-2980736	9.709441e-01	0.013	0	0
Maturation of nucleoprotein	R-HSA-9694631	9.711411e-01	0.013	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.711411e-01	0.013	0	0
RAB geranylgeranylation	R-HSA-8873719	9.716868e-01	0.012	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.716868e-01	0.012	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.723736e-01	0.012	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.727722e-01	0.012	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.744268e-01	0.011	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.745439e-01	0.011	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.745439e-01	0.011	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.751071e-01	0.011	0	0
Keratan sulfate degradation	R-HSA-2022857	9.751071e-01	0.011	0	0
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.751071e-01	0.011	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	9.751071e-01	0.011	0	0
Signaling by NODAL	R-HSA-1181150	9.751071e-01	0.011	0	0
Acyl chain remodelling of PI	R-HSA-1482922	9.751071e-01	0.011	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.751071e-01	0.011	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.751071e-01	0.011	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	9.751071e-01	0.011	0	0
ECM proteoglycans	R-HSA-3000178	9.751451e-01	0.011	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.753079e-01	0.011	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.769847e-01	0.010	0	0
Neurotransmitter release cycle	R-HSA-112310	9.778488e-01	0.010	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.779443e-01	0.010	0	0
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.785283e-01	0.009	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.785283e-01	0.009	0	0
Acyl chain remodelling of PG	R-HSA-1482925	9.785283e-01	0.009	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.793271e-01	0.009	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.811634e-01	0.008	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.812683e-01	0.008	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.812683e-01	0.008	0	0
Heme degradation	R-HSA-189483	9.812683e-01	0.008	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.814795e-01	0.008	0	0
Ribavirin ADME	R-HSA-9755088	9.814795e-01	0.008	0	0
Amine ligand-binding receptors	R-HSA-375280	9.824341e-01	0.008	0	0
Methylation	R-HSA-156581	9.824341e-01	0.008	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.840252e-01	0.007	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.840252e-01	0.007	0	0
Fructose metabolism	R-HSA-5652084	9.840252e-01	0.007	0	0
Ethanol oxidation	R-HSA-71384	9.840252e-01	0.007	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.840252e-01	0.007	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.854698e-01	0.006	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.854698e-01	0.006	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	9.862211e-01	0.006	0	0
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.862211e-01	0.006	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.862211e-01	0.006	0	0
Biosynthesis of maresins	R-HSA-9018682	9.862211e-01	0.006	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.872110e-01	0.006	0	0
RNA Polymerase III Transcription	R-HSA-74158	9.872110e-01	0.006	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.872110e-01	0.006	0	0
Mitochondrial RNA degradation	R-HSA-9836573	9.881152e-01	0.005	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.887482e-01	0.005	0	0
Post-translational protein modification	R-HSA-597592	9.888555e-01	0.005	0	0
Potassium Channels	R-HSA-1296071	9.888906e-01	0.005	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.889158e-01	0.005	0	0
Fertilization	R-HSA-1187000	9.897491e-01	0.004	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.909419e-01	0.004	0	0
Formation of the cornified envelope	R-HSA-6809371	9.913675e-01	0.004	0	0
Mitochondrial protein import	R-HSA-1268020	9.920046e-01	0.003	0	0
Signaling by BMP	R-HSA-201451	9.923741e-01	0.003	0	0
Triglyceride biosynthesis	R-HSA-75109	9.923741e-01	0.003	0	0
Maturation of hRSV A proteins	R-HSA-9828806	9.923741e-01	0.003	0	0
Complex I biogenesis	R-HSA-6799198	9.928367e-01	0.003	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.932464e-01	0.003	0	0
Iron assimilation using enterobactin	R-HSA-9638334	9.934226e-01	0.003	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.938554e-01	0.003	0	0
Intra-Golgi traffic	R-HSA-6811438	9.941023e-01	0.003	0	0
Thyroxine biosynthesis	R-HSA-209968	9.943271e-01	0.002	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.943271e-01	0.002	0	0
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.943271e-01	0.002	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.951072e-01	0.002	0	0
Neurotransmitter clearance	R-HSA-112311	9.951072e-01	0.002	0	0
Paracetamol ADME	R-HSA-9753281	9.951593e-01	0.002	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.955425e-01	0.002	0	0
Aspartate and asparagine metabolism	R-HSA-8963693	9.957801e-01	0.002	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.958829e-01	0.002	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.960135e-01	0.002	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.963257e-01	0.002	0	0
DAG1 glycosylations	R-HSA-8931838	9.963604e-01	0.002	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.964284e-01	0.002	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	9.965036e-01	0.002	0	0
Keratan sulfate biosynthesis	R-HSA-2022854	9.968610e-01	0.001	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.968610e-01	0.001	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.970102e-01	0.001	0	0
Retinoid metabolism and transport	R-HSA-975634	9.970745e-01	0.001	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.971987e-01	0.001	0	0
Glutamate and glutamine metabolism	R-HSA-8964539	9.972928e-01	0.001	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.973520e-01	0.001	0	0
G alpha (s) signalling events	R-HSA-418555	9.974513e-01	0.001	0	0
Collagen degradation	R-HSA-1442490	9.976556e-01	0.001	0	0
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.976652e-01	0.001	0	0
PPARA activates gene expression	R-HSA-1989781	9.977585e-01	0.001	0	0
Collagen formation	R-HSA-1474290	9.978649e-01	0.001	0	0
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.979367e-01	0.001	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.979367e-01	0.001	0	0
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.979864e-01	0.001	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.981036e-01	0.001	0	0
Glycosphingolipid transport	R-HSA-9845576	9.982634e-01	0.001	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.982634e-01	0.001	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.982638e-01	0.001	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.983763e-01	0.001	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	9.983992e-01	0.001	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.984054e-01	0.001	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.984175e-01	0.001	0	0
Complex IV assembly	R-HSA-9864848	9.984175e-01	0.001	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.984395e-01	0.001	0	0
Lysine catabolism	R-HSA-71064	9.985023e-01	0.001	0	0
Collagen chain trimerization	R-HSA-8948216	9.985023e-01	0.001	0	0
Metabolism of folate and pterines	R-HSA-196757	9.985023e-01	0.001	0	0
Purine salvage	R-HSA-74217	9.987084e-01	0.001	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.987311e-01	0.001	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.988633e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.988788e-01	0.000	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.990096e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.990784e-01	0.000	0	0
Aflatoxin activation and detoxification	R-HSA-5423646	9.991716e-01	0.000	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.992856e-01	0.000	0	0
Synthesis of PA	R-HSA-1483166	9.992900e-01	0.000	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.993185e-01	0.000	0	0
Metabolism of cofactors	R-HSA-8978934	9.993185e-01	0.000	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.994573e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.994696e-01	0.000	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.995418e-01	0.000	0	0
SLC transporter disorders	R-HSA-5619102	9.996675e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.996793e-01	0.000	0	0
Synthesis of PC	R-HSA-1483191	9.997062e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.997178e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.997424e-01	0.000	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.997466e-01	0.000	0	0
Keratan sulfate/keratin metabolism	R-HSA-1638074	9.997815e-01	0.000	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.998116e-01	0.000	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.998162e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.998267e-01	0.000	0	0
Cytosolic sulfonation of small molecules	R-HSA-156584	9.998375e-01	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.998396e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.998774e-01	0.000	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.998779e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.998923e-01	0.000	0	0
Metal ion assimilation from the host	R-HSA-9638482	9.998935e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.998935e-01	0.000	0	0
Glucuronidation	R-HSA-156588	9.998958e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.999107e-01	0.000	0	0
tRNA processing	R-HSA-72306	9.999148e-01	0.000	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.999226e-01	0.000	0	0
Sialic acid metabolism	R-HSA-4085001	9.999504e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999550e-01	0.000	0	0
Glutathione conjugation	R-HSA-156590	9.999572e-01	0.000	0	0
Cholesterol biosynthesis	R-HSA-191273	9.999592e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.999626e-01	0.000	0	0
Endogenous sterols	R-HSA-211976	9.999631e-01	0.000	0	0
Nucleotide salvage	R-HSA-8956321	9.999631e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999644e-01	0.000	0	0
Digestion and absorption	R-HSA-8963743	9.999726e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999756e-01	0.000	0	0
Xenobiotics	R-HSA-211981	9.999763e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999804e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999812e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999829e-01	0.000	0	0
Metabolism of steroid hormones	R-HSA-196071	9.999848e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999856e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999896e-01	0.000	0	0
Glycosphingolipid catabolism	R-HSA-9840310	9.999903e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.999928e-01	0.000	0	0
Drug ADME	R-HSA-9748784	9.999946e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.999953e-01	0.000	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999954e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999970e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999981e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999981e-01	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	9.999986e-01	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999993e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999993e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999995e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999997e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999998e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999998e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999998e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.999998e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.999999e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.999999e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999999e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	1.000000e+00	0.000	0	0
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	1.000000e+00	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0