LKB1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O14744 T132 GPS6|PSP PRMT5 HRMT1L5 IBP72 JBP1 SKB1 NFGAYLGLPAFLLPLNQEDNtNLARVLtNHIHtGHHSSMFW
O14744 T139 GPS6|SIGNOR|PSP PRMT5 HRMT1L5 IBP72 JBP1 SKB1 LPAFLLPLNQEDNtNLARVLtNHIHtGHHSSMFWMRVPLVA
O14744 T144 GPS6|SIGNOR|PSP PRMT5 HRMT1L5 IBP72 JBP1 SKB1 LPLNQEDNtNLARVLtNHIHtGHHSSMFWMRVPLVAPEDLR
O14818 T147 Sugiyama PSMA7 HSPC FGISALIVGFDFDGTPRLyQtDPsGtyHAWKANAIGRGAKS
O14818 T152 Sugiyama PSMA7 HSPC LIVGFDFDGTPRLyQtDPsGtyHAWKANAIGRGAKSVREFL
O14818 Y145 Sugiyama PSMA7 HSPC RPFGISALIVGFDFDGTPRLyQtDPsGtyHAWKANAIGRGA
O43390 T134 Sugiyama HNRNPR HNRPR KVQESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O43852 T89 Sugiyama CALU sKERLGKIVSKIDGDKDGFVtVDELKDWIKFAQKRWIyEDV
O60285 T211 GPS6|SIGNOR|ELM|EPSD|PSP NUAK1 ARK5 KIAA0537 OMPHK1 NIKIADFGLSNLYQKDKFLQtFCGSPLYASPEIVNGRPYRG
O60506 T131 Sugiyama SYNCRIP HNRPQ NSAP1 KVADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O75821 T190 Sugiyama EIF3G EIF3S4 PYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNKt
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95757 S599 Sugiyama HSPA4L APG1 HSPH3 OSP94 sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04040 S515 Sugiyama CAT ALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL________
P04040 S517 Sugiyama CAT LDKYNAEKPKNAIHtFVQsGsHLAAREKANL__________
P04040 T29 Sugiyama CAT SDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRGP
P04040 T511 Sugiyama CAT SHIQALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL____
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04637 S15 SIGNOR|EPSD|PSP TP53 P53 ______MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPL
P04637 S392 SIGNOR|EPSD|PSP TP53 P53 KKGQstsRHKKLMFKtEGPDsD___________________
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 T174 Sugiyama HSPB1 HSP27 HSP28 SSsLsPEGtLTVEAPMPKLAtQsNEItIPVtFEsRAQLGGP
P05198 T281 Sugiyama EIF2S1 EIF2A KIEEKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVD
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733 T19 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 __MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGA
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 T26 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P06733 T41 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P06744 T248 Sugiyama GPI WFLQAAKDPSAVAKHFVALstNttKVKEFGIDPQNMFEFWD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07237 T453 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB EAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKFLESG
P07814 S1511 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PGAKCVCGKNPAKyytLFGRsy___________________
P08195 T599 Sugiyama SLC3A2 MDU1 QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238 T85 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238 T89 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSG
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7 T51 Sugiyama TUBA3C TUBA2 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P0DPH7 T56 Sugiyama TUBA3C TUBA2 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T47 Sugiyama HSPA8 HSC70 HSP73 HSPA10 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtNtV
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P11940 T319 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 KNLDDGIDDERLRKEFsPFGtItsAKVMMEGGRSKGFGFVC
P11940 T321 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 LDDGIDDERLRKEFsPFGtItsAKVMMEGGRSKGFGFVCFs
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618 T45 Sugiyama PKM OIP3 PK2 PK3 PKM2 TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15880 S281 Sugiyama RPS2 RPS4 FtKsPyQEFtDHLVKtHtRVsVQRtQAPAVATt________
P17066 T49 Sugiyama HSPA6 HSP70B' EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P18124 T170 Sugiyama RPL7 VNELIyKRGYGKINKKRIALtDNALIARSLGKyGIICMEDL
P18669 T146 Sugiyama PGAM1 PGAMA CDABP0006 MEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIARALPF
P18669 T159 Sugiyama PGAM1 PGAMA CDABP0006 DRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQIKEGK
P19338 T464 Sugiyama NCL KTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWsGE
P20042 T163 Sugiyama EIF2S2 EIF2B DEALEDEDNKKDDGIsFsNQtGPAWAGSERDytyEELLNRV
P20618 S157 Sugiyama PSMB1 PSC5 IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P22314 T233 Sugiyama UBA1 A1S9T UBE1 GEQPLSAMVSMVTKDNPGVVtCLDEARHGFESGDFVSFSEV
P22626 T140 Sugiyama HNRNPA2B1 HNRPA2B1 KEDTEEHHLRDyFEEYGKIDtIEIItDRQsGKKRGFGFVtF
P23284 T81 Sugiyama PPIB CYPB IFGLFGKTVPKTVDNFVALAtGEKGFGYKNSKFHRVIKDFM
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P25786 T11 Sugiyama PSMA1 HC2 NU PROS30 PSC2 __________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26599 T138 PSP PTBP1 PTB TPVLRGQPIyIQFsNHKELKtDSSPNQARAQAALQAVNSVQ
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27448 S215 SIGNOR|EPSD|PSP MARK3 CTAK1 EMK2 ADFGFSNEFTVGGKLDtFCGsPPYAAPELFQGKKYDGPEVD
P27448 T211 GPS6|SIGNOR|EPSD|PSP MARK3 CTAK1 EMK2 NIKIADFGFSNEFTVGGKLDtFCGsPPYAAPELFQGKKYDG
P29401 T444 Sugiyama TKT DGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAANT
P30041 T48 Sugiyama PRDX6 AOP2 KIAA0106 FLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKRNVKL
P30050 T135 Sugiyama RPL12 QMRHRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDI
P30086 T69 Sugiyama PEBP1 PBP PEBP RPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREWHHFLV
P30419 T122 Sugiyama NMT1 NMT GQGPAKTMEEASKRSyQFWDtQPVPKLGEVVNtHGPVEPDK
P34931 T49 Sugiyama HSPA1L EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQNTV
P35579 S1308 Sugiyama MYH9 LLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLs
P35579 T1313 Sugiyama MYH9 DSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLstKLKQ
P35579 T1764 Sugiyama MYH9 NtELINDRLKKANLQIDQINtDLNLERSHAQKNENARQQLE
P35579 T1904 Sugiyama MYH9 EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35579 T1906 Sugiyama MYH9 AQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRGDL
P36578 S63 Sugiyama RPL4 RPL1 NLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGG
P36578 T62 Sugiyama RPL4 RPL1 TNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGG
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 T86 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38646 T94 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P38936 T80 PSP CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 EGDFAWERVRGLGLPKLyLPtGPRRGRDELGGGRRPGtsPA
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40429 T155 Sugiyama RPL13A FAYLGRLAHEVGWKyQAVtAtLEEKRKEKAKIHYRKKKQLM
P41091 T22 Sugiyama EIF2S3 EIF2G AGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAtI
P41091 T430 Sugiyama EIF2S3 EIF2G sLstGGRVSAVKADLGKIVLtNPVCtEVGEKIALSRRVEKH
P41091 T435 Sugiyama EIF2S3 EIF2G GRVSAVKADLGKIVLtNPVCtEVGEKIALSRRVEKHWRLIG
P43490 T179 Sugiyama NAMPT PBEF PBEF1 ITVATNSREQKKILAKyLLEtsGNLDGLEyKLHDFGyRGVS
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46778 T29 Sugiyama RPL21 RGTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQ
P46937 S127 PSP YAP1 YAP65 QAstDAGtAGALtPQHVRAHssPAsLQLGAVsPGtLtPtGV
P48643 T269 Sugiyama CCT5 CCTE KIAA0098 AILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMI
P48741 T49 Sugiyama HSPA7 HSP70B EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P50991 T201 Sugiyama CCT4 CCTD SRB SLLsPMSVNAVMKVIDPAtAtsVDLRDIKIVKKLGGTIDDC
P50991 T50 Sugiyama CCT4 CCTD SRB PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P54646 T172 GPS6|SIGNOR|EPSD|PSP PRKAA2 AMPK AMPK2 NAKIADFGLSNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T48 Sugiyama HSPA2 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTNTI
P57059 T182 GPS6|SIGNOR|ELM|EPSD|PSP SIK1 SIK SNF1LK DIKLADFGFGNFYKSGEPLStWCGsPPYAAPEVFEGKEYEG
P60174 T38 Sugiyama TPI1 TPI RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60174 T46 Sugiyama TPI1 TPI IGtLNAAKVPADtEVVCAPPtAyIDFARQKLDPKIAVAAQN
P60174 T90 Sugiyama TPI1 TPI VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60484 S380 SIGNOR|EPSD|PSP PTEN MMAC1 TEP1 SSsTSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQI
P60484 S385 SIGNOR|iPTMNet|EPSD PTEN MMAC1 TEP1 VtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQItKV__
P60484 T382 GPS6|SIGNOR|ELM|EPSD|PSP PTEN MMAC1 TEP1 sTSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQItK
P60484 T383 SIGNOR|EPSD|PSP PTEN MMAC1 TEP1 TSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQItKV
P60660 T22 Sugiyama MYL6 CDFTEDQTAEFKEAFQLFDRtGDGKILysQCGDVMRALGQN
P60660 T85 Sugiyama MYL6 LDFEHFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVM
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61978 Y72 Sugiyama HNRNPK HNRPK KNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISA
P62241 S160 Sugiyama RPS8 OK/SW-cl.83 KRSKKIQKKYDERKKNAKIssLLEEQFQQGKLLACIASRPG
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62266 T34 Sugiyama RPS23 RSHRRDQKWHDKQYKKAHLGtALKANPFGGAsHAKGIVLEK
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62750 T42 Sugiyama RPL23A LKAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPR
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 T126 Sugiyama YBX1 NSEP1 YB1 GEtVEFDVVEGEKGAEAANVtGPGGVPVQGsKYAADRNHYR
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104 T261 Sugiyama EEF1A1 EEF1A EF1A LENG7 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363 T51 Sugiyama TUBA1B QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P68363 T56 Sugiyama TUBA1B MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T80 Sugiyama TUBA1B KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P83731 S7 Sugiyama RPL24 ______________MKVELCsFsGyKIYPGHGRRYARTDGK
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q00839 T530 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 KTTWVTKHAAENPGKyNILGtNtIMDKMMVAGFKKQMADtG
Q00839 T582 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 CLGKFIEIAARKKRNFILDQtNVsAAAQRRKMCLFAGFQRK
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 S165 Sugiyama SET PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q05639 T261 Sugiyama EEF1A2 EEF1AL STN PTDKPLRLPLQDVyKIGGIGtVPVGRVETGILRPGMVVTFA
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06830 T166 Sugiyama PRDX1 PAGA PAGB TDPX2 DLPVGRsVDEtLRLVQAFQFtDKHGEVCPAGWKPGsDtIKP
Q06830 T18 Sugiyama PRDX1 PAGA PAGB TDPX2 ___MSSGNAKIGHPAPNFKAtAVMPDGQFKDIsLsDyKGKY
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q07020 T87 Sugiyama RPL18 IRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRVTS
Q13131 T183 GPS6|SIGNOR|EPSD|PSP PRKAA1 AMPK1 NAKIADFGLsNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
Q13153 T109 SIGNOR|EPSD|PSP PAK1 FDAVTGEFTGMPEQWARLLQtsNITKsEQKKNPQAVLDVLE
Q13283 S250 Sugiyama G3BP1 G3BP sssPAPADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGI
Q13283 T241 Sugiyama G3BP1 G3BP ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q13283 T255 Sugiyama G3BP1 G3BP PADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGIPPHVV
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13485 T77 EPSD|PSP SMAD4 DPC4 MADH4 LITAITTNGAHPSKCVTIQRtLDGRLQVAGRKGFPHVIYAR
Q14444 T303 Sugiyama CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV
Q14677 S164 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 RLREERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKW
Q14677 T271 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 KDEEETVTTKHIHItQATEttttRHKRTANPsKtIDLGAAA
Q14680 T167 GPS6|SIGNOR|ELM|EPSD|PSP MELK KIAA0175 KLIDFGLCAKPKGNKDyHLQtCCGsLAYAAPELIQGKSYLG
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15293 T100 Sugiyama RCN1 RCN sKERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNV
Q15831 S307 Sugiyama STK11 LKB1 PJS KGMLEYEPAKRFSIRQIRQHsWFRKKHPPAEAPVPIPPsPD
Q15831 S31 Sugiyama STK11 LKB1 PJS MFTEGELMSVGMDTFIHRIDstEVIYQPRRKRAKLIGKYLM
Q15831 S325 Sugiyama STK11 LKB1 PJS QHsWFRKKHPPAEAPVPIPPsPDTKDRWRsMtVVPYLEDLH
Q15831 S428 EPSD|PSP STK11 LKB1 PJS GRAPNPARKACSASSKIRRLsACKQQ_______________
Q15831 S69 Sugiyama STK11 LKB1 PJS YLMGDLLGEGSYGKVKEVLDsETLCRRAVKILKKKKLRRIP
Q15831 T185 SIGNOR|EPSD|PSP STK11 LKB1 PJS EYLHSQGIVHKDIKPGNLLLtTGGtLKISDLGVAEALHPFA
Q15831 T189 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP STK11 LKB1 PJS SQGIVHKDIKPGNLLLtTGGtLKISDLGVAEALHPFAADDT
Q15831 T32 Sugiyama STK11 LKB1 PJS FTEGELMSVGMDTFIHRIDstEVIYQPRRKRAKLIGKYLMG
Q15831 T336 GPS6|SIGNOR|EPSD|PSP STK11 LKB1 PJS AEAPVPIPPsPDTKDRWRsMtVVPYLEDLHGADEDEDLFDI
Q15831 T363 GPS6|SIGNOR|EPSD|PSP STK11 LKB1 PJS DLHGADEDEDLFDIEDDIIYtQDFtVPGQVPEEEASHNGQR
Q15831 T395 Sugiyama STK11 LKB1 PJS EEASHNGQRRGLPKAVCMNGtEAAQLStKSRAEGRAPNPAR
Q15831 T402 SIGNOR|EPSD|PSP|Sugiyama STK11 LKB1 PJS QRRGLPKAVCMNGtEAAQLStKSRAEGRAPNPARKACSASS
Q2VIR3 T22 Sugiyama EIF2S3B AGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAtI
Q2VIR3 T430 Sugiyama EIF2S3B sLstGGRVSAVKADLGKIVLtNPVCtEVGEKIALSRRVEKH
Q2VIR3 T435 Sugiyama EIF2S3B GRVSAVKADLGKIVLtNPVCtEVGEKIALSRRVEKHWRLIG
Q562R1 T107 Sugiyama ACTBL2 WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q5H9R7 S579 Sugiyama PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q5VTE0 T261 Sugiyama EEF1A1P5 EEF1AL3 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q684P5 S544 Sugiyama RAP1GAP2 GARNL4 KIAA1039 RAP1GA2 PGSLSGGISHNSMEVTKtTFsPPVVAATVKNQSRSPIKRRS
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2 T51 Sugiyama TUBA3E QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6PEY2 T56 Sugiyama TUBA3E MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6UUV9 S151 PSP CRTC1 KIAA0616 MECT1 TORC1 WAMTP1 CPYGTMYLsPPADTSWRRtNsDsALHQstMtPtQPEsFssG
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36 T51 Sugiyama TUBA1A TUBA3 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q71U36 T56 Sugiyama TUBA1A TUBA3 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T80 Sugiyama TUBA1A TUBA3 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q7KZI7 T208 GPS6|SIGNOR|ELM|EPSD|PSP MARK2 EMK1 NIKIADFGFSNEFTFGNKLDtFCGsPPYAAPELFQGKKYDG
Q7RTN6 S46 Sugiyama STRADA LYK5 STRAD DLELFGEQPPGDtRRKtNDAssEsIAsFSKQEVMSSFLPEG
Q7RTN6 S47 Sugiyama STRADA LYK5 STRAD LELFGEQPPGDtRRKtNDAssEsIAsFSKQEVMSSFLPEGG
Q7RTN6 S49 Sugiyama STRADA LYK5 STRAD LFGEQPPGDtRRKtNDAssEsIAsFSKQEVMSSFLPEGGCY
Q7RTN6 S52 Sugiyama STRADA LYK5 STRAD EQPPGDtRRKtNDAssEsIAsFSKQEVMSSFLPEGGCYELL
Q7RTN6 T329 GPS6|SIGNOR|EPSD|PSP STRADA LYK5 STRAD ELTMsPSRSVANSGLSDsLTtStPRPSNGDsPSHPYHRTFS
Q7RTN6 T38 Sugiyama STRADA LYK5 STRAD KFIVEGLRDLELFGEQPPGDtRRKtNDAssEsIAsFSKQEV
Q7RTN6 T419 GPS6|SIGNOR|EPSD|PSP STRADA LYK5 STRAD PITNFEGSQSQDHSGIFGLVtNLEELEVDDWEF________
Q7RTN6 T42 Sugiyama STRADA LYK5 STRAD EGLRDLELFGEQPPGDtRRKtNDAssEsIAsFSKQEVMSSF
Q7Z2W4 T363 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 NPGstyLASNsTsAPNWKsLtsWtNDQGARRKtVFsPtLPA
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q86V81 S8 Sugiyama ALYREF ALY BEF THOC4 _____________MADKMDMsLDDIIKLNRSQRGGRGGGRG
Q8IWQ3 T174 GPS6|SIGNOR|ELM|EPSD|PSP BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12 NIRIADFGMASLQVGDSLLEtSCGSPHYACPEVIRGEKYDG
Q8N1G4 T27 Sugiyama LRRC47 KIAA1185 SESWPELELAERERRRELLLtGPGLEERVRAAGGQLPPRLF
Q8NBJ7 T260 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 SPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMGNtPD
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TDC3 T189 GPS6|SIGNOR|EPSD|PSP BRSK1 KIAA1811 SAD1 SADB NIRIADFGMASLQVGDSLLEtSCGSPHYACPEVIKGEKYDG
Q96EB6 S615 GPS6|SIGNOR|PSP SIRT1 SIR2L1 MENPDLKNVGSSTGEKNERtsVAGTVRKCWPNRVAKEQISR
Q96EB6 S669 GPS6|SIGNOR|PSP SIRT1 SIR2L1 RYIFHGAEVYsDsEDDVLSSsSCGSNSDSGTCQsPSLEEPM
Q96EB6 S732 GPS6|SIGNOR|PSP SIRT1 SIR2L1 AGGAGFGtDGDDQEAINEAIsVKQEVTDMNYPsNKs_____
Q96L34 T214 GPS6|SIGNOR|ELM|EPSD|PSP MARK4 KIAA1860 MARKL1 NIKIADFGFSNEFTLGSKLDtFCGsPPYAAPELFQGKKYDG
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3 T51 Sugiyama TUBA1C TUBA6 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BQE3 T56 Sugiyama TUBA1C TUBA6 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T80 Sugiyama TUBA1C TUBA6 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9C037 Y449 Sugiyama TRIM4 RNF87 LIGFPGTPTQQEPALHRVGVyLDRGTGNVSFYSAVDGVHLH
Q9H093 T208 GPS6|SIGNOR|ELM|EPSD|PSP NUAK2 OMPHK2 SNARK NIKIADFGLSNLYHQGKFLQtFCGSPLYASPEIVNGKPYTG
Q9H0K1 T175 GPS6|SIGNOR|ELM|EPSD|PSP SIK2 KIAA0781 QIK SNF1LK2 NIKIADFGFGNFFKSGELLAtWCGSPPYAAPEVFEGQQYEG
Q9NRH2 T173 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SNRK KIAA0096 SNFRK LVKLTDFGFsNKFQPGKKLTtSCGSLAYSAPEILLGDEYDA
Q9NVR5 S773 Sugiyama DNAAF2 C14orf104 KTU EFIKEKSATCSNEEKDNLNEsVITEEKETDGDHLsSLLNKT
Q9P0L2 S219 iPTMNet|EPSD MARK1 KIAA1477 MARK ADFGFSNEFTVGNKLDtFCGsPPYAAPELFQGKKYDGPEVD
Q9P0L2 T215 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MARK1 KIAA1477 MARK NIKIADFGFSNEFTVGNKLDtFCGsPPYAAPELFQGKKYDG
Q9UNF1 T90 Sugiyama MAGED2 BCG1 sKtPEAREAPAtQAssttQLtDtQVLAAENKSLAADTKKQN
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2K2 T221 SIGNOR|PSP SIK3 KIAA0999 QSK L19 NIKIADFGFSNLFTPGQLLKtWCGSPPYAAPELFEGKEYDG
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle, Mitotic R-HSA-69278 0.000004 5.413 0 0
Cell Cycle R-HSA-1640170 0.000005 5.298 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.000007 5.166 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.000020 4.705 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.000028 4.546 0 0
Notch-HLH transcription pathway R-HSA-350054 0.000033 4.476 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 0.000054 4.269 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 0.000053 4.275 0 0
Transport of connexons to the plasma membrane R-HSA-190872 0.000070 4.156 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.000080 4.100 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.000105 3.980 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 0.000117 3.934 0 0
Membrane Trafficking R-HSA-199991 0.000106 3.975 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.000205 3.687 0 0
Kinesins R-HSA-983189 0.000201 3.696 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 0.000223 3.651 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 0.000254 3.596 0 0
Mitotic Anaphase R-HSA-68882 0.000265 3.576 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.000281 3.551 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.000316 3.500 0 0
MHC class II antigen presentation R-HSA-2132295 0.000337 3.472 0 0
Separation of Sister Chromatids R-HSA-2467813 0.000391 3.408 0 0
Mitotic Prometaphase R-HSA-68877 0.000391 3.407 0 0
Axon guidance R-HSA-422475 0.000430 3.366 0 0
Nervous system development R-HSA-9675108 0.000446 3.350 0 0
PKR-mediated signaling R-HSA-9833482 0.000484 3.315 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.000534 3.272 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.000526 3.279 0 0
G1/S-Specific Transcription R-HSA-69205 0.000596 3.225 0 0
Recycling pathway of L1 R-HSA-437239 0.000688 3.163 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.000693 3.159 0 0
Regulation of TP53 Activity R-HSA-5633007 0.000787 3.104 1 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.000847 3.072 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.000828 3.082 0 0
Post NMDA receptor activation events R-HSA-438064 0.001018 2.992 0 0
Signaling by NOTCH1 R-HSA-1980143 0.001129 2.947 0 0
G1/S Transition R-HSA-69206 0.001197 2.922 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.001340 2.873 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.001363 2.866 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.001430 2.845 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.001544 2.811 0 0
Chromatin modifying enzymes R-HSA-3247509 0.001603 2.795 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.001623 2.790 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.001582 2.801 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 0.001674 2.776 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.001970 2.706 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.002033 2.692 0 0
Cellular responses to stress R-HSA-2262752 0.002041 2.690 0 0
Neurodegenerative Diseases R-HSA-8863678 0.001980 2.703 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.001980 2.703 0 0
Gap junction assembly R-HSA-190861 0.002089 2.680 0 0
NRAGE signals death through JNK R-HSA-193648 0.001932 2.714 0 0
Cell Cycle Checkpoints R-HSA-69620 0.002252 2.647 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.002719 2.566 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.002880 2.541 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.002880 2.541 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.002880 2.541 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.002880 2.541 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.002880 2.541 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.002681 2.572 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.002681 2.572 0 0
Interferon Signaling R-HSA-913531 0.002690 2.570 0 0
M Phase R-HSA-68886 0.002596 2.586 0 0
Specification of primordial germ cells R-HSA-9827857 0.002708 2.567 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.003137 2.503 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.003157 2.501 0 0
Chromatin organization R-HSA-4839726 0.003174 2.498 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 0.003396 2.469 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.003388 2.470 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.003485 2.458 0 0
G2/M Transition R-HSA-69275 0.003551 2.450 0 0
Signaling by ROBO receptors R-HSA-376176 0.003658 2.437 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.003907 2.408 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.003918 2.407 0 0
Aggrephagy R-HSA-9646399 0.004387 2.358 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.004391 2.357 0 0
Protein folding R-HSA-391251 0.004892 2.311 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.004905 2.309 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.005042 2.297 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.005170 2.286 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.005851 2.233 0 0
Gene expression (Transcription) R-HSA-74160 0.006276 2.202 1 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.006872 2.163 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.006881 2.162 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.006960 2.157 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.007432 2.129 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.007451 2.128 0 0
Gap junction trafficking R-HSA-190828 0.007451 2.128 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.008328 2.079 1 1
Cellular responses to stimuli R-HSA-8953897 0.007768 2.110 0 0
mRNA Splicing R-HSA-72172 0.008480 2.072 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.009255 2.034 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.009257 2.034 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.008887 2.051 0 0
Signaling by NOTCH R-HSA-157118 0.008979 2.047 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 0.009255 2.034 0 0
Vesicle-mediated transport R-HSA-5653656 0.008893 2.051 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.008654 2.063 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.009430 2.025 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 0.009920 2.003 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.010247 1.989 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.010972 1.960 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.011068 1.956 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.011318 1.946 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.012355 1.908 0 0
Gap junction trafficking and regulation R-HSA-157858 0.011868 1.926 0 0
G alpha (12/13) signalling events R-HSA-416482 0.012374 1.907 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 0.012938 1.888 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.013121 1.882 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.013353 1.874 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.014716 1.832 0 0
Metabolism of RNA R-HSA-8953854 0.015307 1.815 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.016566 1.781 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.017440 1.758 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.017440 1.758 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.017440 1.758 0 0
RNA Polymerase II Transcription R-HSA-73857 0.015904 1.799 1 0
Death Receptor Signaling R-HSA-73887 0.017011 1.769 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.017642 1.753 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 0.019526 1.709 0 0
Activation of the pre-replicative complex R-HSA-68962 0.019736 1.705 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.020854 1.681 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.022527 1.647 0 0
G0 and Early G1 R-HSA-1538133 0.024178 1.617 0 0
Adipogenesis R-HSA-9843745 0.025330 1.596 0 0
L1CAM interactions R-HSA-373760 0.025127 1.600 0 0
Selective autophagy R-HSA-9663891 0.024572 1.610 0 0
Activation of RAC1 R-HSA-428540 0.026776 1.572 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.026776 1.572 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.026776 1.572 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.027299 1.564 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 0.027351 1.563 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 0.027351 1.563 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 0.027351 1.563 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 0.027351 1.563 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 0.027351 1.563 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 0.027351 1.563 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 0.027351 1.563 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.028869 1.540 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.029016 1.537 0 0
Gastrulation R-HSA-9758941 0.028546 1.544 0 0
Generic Transcription Pathway R-HSA-212436 0.031135 1.507 1 0
SARS-CoV-1-host interactions R-HSA-9692914 0.031473 1.502 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.031517 1.501 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.031517 1.501 0 0
Disorders of Nervous System Development R-HSA-9697154 0.031517 1.501 0 0
Pervasive developmental disorders R-HSA-9005895 0.031517 1.501 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.031517 1.501 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.031700 1.499 0 0
RNA Polymerase I Transcription R-HSA-73864 0.032461 1.489 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.033752 1.472 0 0
Intraflagellar transport R-HSA-5620924 0.033933 1.469 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.034873 1.458 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 0.036216 1.441 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 0.036216 1.441 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.036667 1.436 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 0.041529 1.382 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 0.041529 1.382 0 0
TGFBR3 expression R-HSA-9839394 0.044426 1.352 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.040612 1.391 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.043551 1.361 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 0.046023 1.337 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.046023 1.337 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.048094 1.318 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.048169 1.317 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.048169 1.317 0 0
Formation of the anterior neural plate R-HSA-9823739 0.048169 1.317 0 0
Hedgehog 'off' state R-HSA-5610787 0.050073 1.300 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.051083 1.292 0 0
Interferon alpha/beta signaling R-HSA-909733 0.051589 1.287 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.051804 1.286 0 0
Diseases of Immune System R-HSA-5260271 0.051804 1.286 0 0
Signaling by NOTCH3 R-HSA-9012852 0.054159 1.266 0 0
Disorders of Developmental Biology R-HSA-9675151 0.061217 1.213 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.060308 1.220 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.055676 1.254 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.062417 1.205 0 0
RSV-host interactions R-HSA-9833110 0.062310 1.205 0 0
S Phase R-HSA-69242 0.054268 1.265 0 0
Diseases of programmed cell death R-HSA-9645723 0.057663 1.239 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 0.056676 1.247 0 0
Signal Transduction R-HSA-162582 0.058673 1.232 1 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.054505 1.264 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.061036 1.214 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.063509 1.197 0 0
Developmental Biology R-HSA-1266738 0.066245 1.179 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.066763 1.175 1 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.067615 1.170 0 0
MECP2 regulates transcription factors R-HSA-9022707 0.068091 1.167 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 0.068091 1.167 0 0
Signaling by Hippo R-HSA-2028269 0.068295 1.166 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.068854 1.162 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.068854 1.162 0 0
Signaling by Hedgehog R-HSA-5358351 0.070102 1.154 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.070492 1.152 0 0
Signaling by ALK in cancer R-HSA-9700206 0.070492 1.152 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.081335 1.090 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.081335 1.090 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.081335 1.090 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.081335 1.090 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.081335 1.090 0 0
Type I hemidesmosome assembly R-HSA-446107 0.080184 1.096 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.076272 1.118 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.077461 1.111 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.077461 1.111 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 0.080184 1.096 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.073361 1.135 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 0.081335 1.090 0 0
Inhibition of PKR R-HSA-169131 0.081335 1.090 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.074423 1.128 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.084628 1.072 0 0
Signaling by PTK6 R-HSA-8848021 0.084628 1.072 0 0
Macroautophagy R-HSA-1632852 0.077684 1.110 0 0
Autophagy R-HSA-9612973 0.071336 1.147 0 0
Heme signaling R-HSA-9707616 0.080389 1.095 0 0
Polo-like kinase mediated events R-HSA-156711 0.075725 1.121 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.080213 1.096 0 0
Apoptotic execution phase R-HSA-75153 0.082297 1.085 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 0.119491 0.923 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 0.119491 0.923 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 0.119491 0.923 0 0
Defective CD320 causes MMATC R-HSA-3359485 0.119491 0.923 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.156064 0.807 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.156064 0.807 0 0
Regulation of cortical dendrite branching R-HSA-8985801 0.156064 0.807 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.156064 0.807 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.156064 0.807 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.156064 0.807 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.156064 0.807 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.156064 0.807 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.156064 0.807 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.156064 0.807 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 0.156064 0.807 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.156064 0.807 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.156064 0.807 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 0.191120 0.719 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 0.191120 0.719 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 0.191120 0.719 0 0
Invadopodia formation R-HSA-8941237 0.191120 0.719 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.092881 1.032 0 0
MTF1 activates gene expression R-HSA-5660489 0.224722 0.648 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.224722 0.648 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.224722 0.648 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.224722 0.648 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 0.106111 0.974 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.106111 0.974 0 0
Signaling by APC mutants R-HSA-4839744 0.119807 0.922 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.119807 0.922 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.119807 0.922 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.119807 0.922 0 0
IRS activation R-HSA-74713 0.256931 0.590 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.256931 0.590 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.133908 0.873 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.133908 0.873 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.148357 0.829 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.148357 0.829 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.148357 0.829 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.148357 0.829 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.148357 0.829 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.148357 0.829 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 0.287802 0.541 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 0.287802 0.541 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 0.287802 0.541 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.287802 0.541 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 0.287802 0.541 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.287802 0.541 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 0.287802 0.541 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 0.287802 0.541 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 0.287802 0.541 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 0.287802 0.541 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.091590 1.038 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.163101 0.788 0 0
Prolactin receptor signaling R-HSA-1170546 0.178090 0.749 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 0.178090 0.749 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 0.317394 0.498 0 0
Signaling by LTK in cancer R-HSA-9842640 0.317394 0.498 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.317394 0.498 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 0.317394 0.498 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 0.317394 0.498 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.117684 0.929 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.193280 0.714 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 0.193280 0.714 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.092436 1.034 0 0
Deadenylation of mRNA R-HSA-429947 0.136433 0.865 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.136433 0.865 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 0.208627 0.681 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 0.345757 0.461 0 0
SOS-mediated signalling R-HSA-112412 0.345757 0.461 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 0.345757 0.461 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.224092 0.650 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 0.224092 0.650 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.156120 0.807 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.166275 0.779 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 0.239639 0.620 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 0.372943 0.428 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 0.372943 0.428 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.255234 0.593 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.187134 0.728 0 0
mRNA 3'-end processing R-HSA-72187 0.114524 0.941 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 0.270848 0.567 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.270848 0.567 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.399002 0.399 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 0.399002 0.399 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.165030 0.782 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.286451 0.543 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.286451 0.543 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.286451 0.543 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.286451 0.543 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.302017 0.520 0 0
Folding of actin by CCT/TriC R-HSA-390450 0.423979 0.373 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.128090 0.892 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.198458 0.702 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.317523 0.498 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.253015 0.597 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 0.332947 0.478 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.111905 0.951 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.186291 0.730 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.186291 0.730 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.141653 0.849 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.208203 0.682 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.251873 0.599 0 0
Orc1 removal from chromatin R-HSA-68949 0.251873 0.599 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.363470 0.440 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.161056 0.793 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.161056 0.793 0 0
Translation initiation complex formation R-HSA-72649 0.270317 0.568 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.378535 0.422 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.288987 0.539 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.262182 0.581 0 0
Centrosome maturation R-HSA-380287 0.278177 0.556 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.253262 0.596 0 0
Metabolism of non-coding RNA R-HSA-194441 0.317294 0.499 0 0
snRNP Assembly R-HSA-191859 0.317294 0.499 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.244245 0.612 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.326785 0.486 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.250544 0.601 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.184568 0.734 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.302513 0.519 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.288845 0.539 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.296090 0.529 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.374371 0.427 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.423973 0.373 0 0
Viral mRNA Translation R-HSA-192823 0.355054 0.450 0 0
PPARA activates gene expression R-HSA-1989781 0.315391 0.501 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.421666 0.375 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.326989 0.485 0 0
Ribosome-associated quality control R-HSA-9948299 0.337824 0.471 0 0
Formation of definitive endoderm R-HSA-9823730 0.286451 0.543 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.393449 0.405 0 0
Telomere Extension By Telomerase R-HSA-171319 0.422769 0.374 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.410104 0.387 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.117630 0.929 0 0
EGFR downregulation R-HSA-182971 0.208621 0.681 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.197806 0.704 1 1
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.378863 0.422 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.401538 0.396 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.401538 0.396 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.401538 0.396 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.363470 0.440 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.344541 0.463 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.307827 0.512 0 0
HCMV Early Events R-HSA-9609690 0.131598 0.881 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.224092 0.650 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.230619 0.637 0 0
Regulation of CDH11 function R-HSA-9762292 0.423979 0.373 0 0
PI3K/AKT activation R-HSA-198203 0.423979 0.373 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.317523 0.498 0 0
Peptide chain elongation R-HSA-156902 0.122282 0.913 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.321556 0.493 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.086219 1.064 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.390227 0.409 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.241774 0.617 0 0
IRAK1 recruits IKK complex R-HSA-937039 0.148357 0.829 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 0.148357 0.829 0 0
cGMP effects R-HSA-418457 0.178090 0.749 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.224092 0.650 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.112309 0.950 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.166275 0.779 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 0.399002 0.399 1 1
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.230619 0.637 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.317523 0.498 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.275703 0.560 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.315835 0.501 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.205791 0.687 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 0.187134 0.728 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.241774 0.617 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.315835 0.501 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.136433 0.865 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.133482 0.875 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.144584 0.840 0 0
COPII-mediated vesicle transport R-HSA-204005 0.421666 0.375 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.088774 1.052 0 0
Calcineurin activates NFAT R-HSA-2025928 0.092881 1.032 0 0
Formation of the posterior neural plate R-HSA-9832991 0.119807 0.922 0 0
Activation of AKT2 R-HSA-165158 0.256931 0.590 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 0.256931 0.590 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.098861 1.005 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.224092 0.650 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 0.372943 0.428 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.230619 0.637 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.107391 0.969 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.250544 0.601 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.345810 0.461 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.390227 0.409 0 0
Signaling by RAS mutants R-HSA-6802949 0.401538 0.396 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.407301 0.390 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.199659 0.700 0 0
Signaling by WNT in cancer R-HSA-4791275 0.219563 0.658 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.393361 0.405 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.145296 0.838 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 0.224722 0.648 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 0.256931 0.590 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.224092 0.650 0 0
Lipophagy R-HSA-9613354 0.399002 0.399 0 0
HDACs deacetylate histones R-HSA-3214815 0.132587 0.877 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.219563 0.658 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 0.423979 0.373 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.158503 0.800 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.238621 0.622 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.408197 0.389 0 0
Eukaryotic Translation Termination R-HSA-72764 0.296090 0.529 0 0
Circadian clock R-HSA-9909396 0.103351 0.986 0 0
G2/M Checkpoints R-HSA-69481 0.258572 0.587 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.089088 1.050 0 0
Co-inhibition by PD-1 R-HSA-389948 0.144756 0.839 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.120407 0.919 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.286451 0.543 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.246411 0.608 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.408197 0.389 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 0.399002 0.399 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.253015 0.597 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.307827 0.512 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.187134 0.728 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.128090 0.892 0 0
PTEN Regulation R-HSA-6807070 0.131808 0.880 0 0
HCMV Infection R-HSA-9609646 0.361089 0.442 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 0.119491 0.923 0 0
mRNA Editing: A to I Conversion R-HSA-75064 0.156064 0.807 0 0
C6 deamination of adenosine R-HSA-75102 0.156064 0.807 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.191120 0.719 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 0.256931 0.590 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.133908 0.873 0 0
Signaling by AXIN mutants R-HSA-4839735 0.133908 0.873 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 0.287802 0.541 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 0.287802 0.541 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.163101 0.788 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.141437 0.849 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.141437 0.849 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.141437 0.849 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 0.423979 0.373 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.423979 0.373 0 0
Metabolism of serotonin R-HSA-380612 0.423979 0.373 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.253015 0.597 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.310062 0.509 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.321556 0.493 0 0
Myogenesis R-HSA-525793 0.393449 0.405 0 0
Meiosis R-HSA-1500620 0.360298 0.443 0 0
Cellular response to chemical stress R-HSA-9711123 0.111415 0.953 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.230619 0.637 0 0
Cellular response to heat stress R-HSA-3371556 0.218527 0.660 0 0
Cilium Assembly R-HSA-5617833 0.182743 0.738 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.368607 0.433 0 0
Somitogenesis R-HSA-9824272 0.390227 0.409 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.325336 0.488 0 0
Extension of Telomeres R-HSA-180786 0.317294 0.499 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.108700 0.964 0 0
rRNA processing R-HSA-72312 0.276641 0.558 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.207600 0.683 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.207539 0.683 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.207539 0.683 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 0.345757 0.461 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 0.224092 0.650 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.128253 0.892 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.369967 0.432 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.369967 0.432 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.224102 0.650 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.224102 0.650 0 0
Signal attenuation R-HSA-74749 0.423979 0.373 0 0
TRP channels R-HSA-3295583 0.393449 0.405 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.223255 0.651 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.173260 0.761 0 0
Cellular Senescence R-HSA-2559583 0.086061 1.065 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.286729 0.543 0 0
DCC mediated attractive signaling R-HSA-418885 0.193280 0.714 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.318915 0.496 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.172179 0.764 0 0
Mitotic Prophase R-HSA-68875 0.342799 0.465 0 0
DNA Replication R-HSA-69306 0.303883 0.517 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.184423 0.734 0 0
Signaling by LTK R-HSA-9842663 0.148357 0.829 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 0.287802 0.541 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.345757 0.461 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 0.399002 0.399 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 0.399002 0.399 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 0.423979 0.373 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.423979 0.373 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.298581 0.525 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.184423 0.734 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.184423 0.734 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.128090 0.892 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.108709 0.964 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.352979 0.452 0 0
Proteasome assembly R-HSA-9907900 0.378863 0.422 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.355333 0.449 0 0
Synthesis of DNA R-HSA-69239 0.244245 0.612 0 0
Neurexins and neuroligins R-HSA-6794361 0.251873 0.599 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.108700 0.964 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.224092 0.650 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.363470 0.440 0 0
TNF signaling R-HSA-75893 0.288987 0.539 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.204110 0.690 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.086219 1.064 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.287124 0.542 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.186251 0.730 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.172621 0.763 0 0
Breakdown of the nuclear lamina R-HSA-352238 0.119491 0.923 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 0.224722 0.648 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.178090 0.749 0 0
LDL remodeling R-HSA-8964041 0.345757 0.461 0 0
TRIF-mediated programmed cell death R-HSA-2562578 0.345757 0.461 0 0
Nucleotide salvage defects R-HSA-9734207 0.372943 0.428 0 0
mRNA Editing R-HSA-75072 0.399002 0.399 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 0.399002 0.399 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.126429 0.898 0 0
HATs acetylate histones R-HSA-3214847 0.190114 0.721 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.401538 0.396 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.351995 0.453 0 0
Cell junction organization R-HSA-446728 0.287375 0.542 0 0
Signaling by VEGF R-HSA-194138 0.246899 0.607 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.279994 0.553 0 0
Adaptive Immune System R-HSA-1280218 0.357683 0.447 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.092772 1.033 0 0
Rab regulation of trafficking R-HSA-9007101 0.109613 0.960 0 0
RUNX2 regulates bone development R-HSA-8941326 0.275703 0.560 0 0
MTOR signalling R-HSA-165159 0.165030 0.782 1 0
Sema4D in semaphorin signaling R-HSA-400685 0.378535 0.422 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.333052 0.477 0 0
Interleukin-1 signaling R-HSA-9020702 0.107899 0.967 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.205791 0.687 0 0
Reproduction R-HSA-1474165 0.096848 1.014 0 0
Toll-like Receptor Cascades R-HSA-168898 0.282201 0.549 0 0
Cyclin D associated events in G1 R-HSA-69231 0.378863 0.422 0 0
G1 Phase R-HSA-69236 0.378863 0.422 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.412789 0.384 0 0
Suppression of apoptosis R-HSA-9635465 0.119807 0.922 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.317394 0.498 0 0
Rap1 signalling R-HSA-392517 0.270848 0.567 0 0
Receptor Mediated Mitophagy R-HSA-8934903 0.423979 0.373 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.264329 0.578 0 0
HSF1 activation R-HSA-3371511 0.275703 0.560 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.408197 0.389 0 0
Selenocysteine synthesis R-HSA-2408557 0.340186 0.468 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.399839 0.398 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.333052 0.477 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.401538 0.396 0 0
OAS antiviral response R-HSA-8983711 0.148357 0.829 0 0
Nuclear RNA decay R-HSA-9930044 0.230619 0.637 0 0
Signaling by TGFBR3 R-HSA-9839373 0.198458 0.702 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.229728 0.639 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 0.224722 0.648 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 0.256931 0.590 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 0.287802 0.541 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.193280 0.714 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 0.345757 0.461 0 0
RSK activation R-HSA-444257 0.372943 0.428 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.399002 0.399 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.230619 0.637 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.310062 0.509 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.362506 0.441 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.360298 0.443 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.329275 0.482 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.192099 0.716 0 0
Other interleukin signaling R-HSA-449836 0.270848 0.567 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.302017 0.520 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.423979 0.373 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.086219 1.064 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.407301 0.390 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.363047 0.440 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.148357 0.829 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.126934 0.896 0 0
Cardiogenesis R-HSA-9733709 0.086219 1.064 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.142275 0.847 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.106111 0.974 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.399002 0.399 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.238621 0.622 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.326785 0.486 0 0
TBC/RABGAPs R-HSA-8854214 0.367456 0.435 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.345810 0.461 0 0
Interleukin-1 processing R-HSA-448706 0.092881 1.032 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.256931 0.590 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.287802 0.541 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.287802 0.541 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 0.099997 1.000 0 0
Nef and signal transduction R-HSA-164944 0.317394 0.498 0 0
VLDL assembly R-HSA-8866423 0.317394 0.498 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.193280 0.714 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.126934 0.896 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 0.239639 0.620 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 0.399002 0.399 0 0
Regulated proteolysis of p75NTR R-HSA-193692 0.399002 0.399 0 0
Signaling by NOTCH4 R-HSA-9013694 0.138981 0.857 0 0
CREB3 factors activate genes R-HSA-8874211 0.317394 0.498 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.092436 1.034 0 0
Signal transduction by L1 R-HSA-445144 0.286451 0.543 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.224752 0.648 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.224752 0.648 0 0
Netrin-1 signaling R-HSA-373752 0.378863 0.422 0 0
Interferon gamma signaling R-HSA-877300 0.223486 0.651 0 0
Neuronal System R-HSA-112316 0.419483 0.377 0 0
Negative regulation of MET activity R-HSA-6807004 0.286451 0.543 0 0
Glycosphingolipid transport R-HSA-9845576 0.275703 0.560 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.288987 0.539 0 0
Diseases of DNA repair R-HSA-9675135 0.401538 0.396 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.108700 0.964 0 0
Viral Infection Pathways R-HSA-9824446 0.234076 0.631 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.275703 0.560 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.364855 0.438 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 0.345757 0.461 0 0
Nephron development R-HSA-9831926 0.255234 0.593 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.310062 0.509 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.099997 1.000 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.399002 0.399 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.124332 0.905 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.270848 0.567 0 0
Signaling by Leptin R-HSA-2586552 0.423979 0.373 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 0.372943 0.428 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.399002 0.399 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.317523 0.498 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.298581 0.525 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.108700 0.964 0 0
Interleukin-23 signaling R-HSA-9020933 0.372943 0.428 0 0
RET signaling R-HSA-8853659 0.275703 0.560 0 0
SARS-CoV Infections R-HSA-9679506 0.401072 0.397 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.344095 0.463 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.127796 0.893 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.332947 0.478 0 0
Growth hormone receptor signaling R-HSA-982772 0.348269 0.458 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.219024 0.660 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.208627 0.681 0 0
IRE1alpha activates chaperones R-HSA-381070 0.260284 0.585 0 0
The NLRP3 inflammasome R-HSA-844456 0.270848 0.567 0 0
Inflammasomes R-HSA-622312 0.422769 0.374 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.427604 0.369 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.427604 0.369 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.431034 0.365 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.431034 0.365 0 0
Hedgehog 'on' state R-HSA-5632684 0.431034 0.365 0 0
Interleukin-1 family signaling R-HSA-446652 0.432777 0.364 0 0
EPH-Ephrin signaling R-HSA-2682334 0.434835 0.362 0 0
DNA Damage Bypass R-HSA-73893 0.435082 0.361 0 0
Degradation of CDH1 R-HSA-9766229 0.435082 0.361 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.437045 0.359 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.437153 0.359 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.437153 0.359 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.439108 0.357 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.446110 0.351 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.447919 0.349 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 0.447919 0.349 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.447919 0.349 0 0
Chylomicron assembly R-HSA-8963888 0.447919 0.349 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 0.447919 0.349 0 0
Transport of RCbl within the body R-HSA-9758890 0.447919 0.349 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 0.447919 0.349 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 0.447919 0.349 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.449642 0.347 0 0
Ca2+ pathway R-HSA-4086398 0.449642 0.347 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.451340 0.345 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.451340 0.345 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.451340 0.345 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.451340 0.345 0 0
Cell-Cell communication R-HSA-1500931 0.456452 0.341 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.457052 0.340 0 0
HSF1-dependent transactivation R-HSA-3371571 0.457052 0.340 0 0
Meiotic recombination R-HSA-912446 0.457052 0.340 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.458874 0.338 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.459178 0.338 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.459178 0.338 0 0
Influenza Infection R-HSA-168255 0.463178 0.334 0 0
Cargo concentration in the ER R-HSA-5694530 0.465321 0.332 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.467435 0.330 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.467902 0.330 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.467902 0.330 0 0
Cellular response to starvation R-HSA-9711097 0.470595 0.327 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 0.470866 0.327 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.470866 0.327 0 0
NF-kB is activated and signals survival R-HSA-209560 0.470866 0.327 0 0
Smooth Muscle Contraction R-HSA-445355 0.478654 0.320 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.479089 0.320 0 0
Signaling by WNT R-HSA-195721 0.480953 0.318 0 0
Telomere Maintenance R-HSA-157579 0.483521 0.316 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.486678 0.313 0 0
Transmission across Chemical Synapses R-HSA-112315 0.488077 0.312 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.489303 0.310 0 0
MAPK family signaling cascades R-HSA-5683057 0.490359 0.309 0 0
Integrin signaling R-HSA-354192 0.492637 0.307 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.492637 0.307 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.492637 0.307 0 0
G-protein beta:gamma signalling R-HSA-397795 0.492637 0.307 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.492637 0.307 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.492860 0.307 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 0.492860 0.307 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 0.492860 0.307 0 0
Repression of WNT target genes R-HSA-4641265 0.492860 0.307 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.492860 0.307 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.492860 0.307 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 0.492860 0.307 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 0.492860 0.307 0 0
Regulation of IFNG signaling R-HSA-877312 0.492860 0.307 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 0.492860 0.307 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 0.492860 0.307 0 0
Interleukin-15 signaling R-HSA-8983432 0.492860 0.307 0 0
Deubiquitination R-HSA-5688426 0.500156 0.301 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.504161 0.297 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.505960 0.296 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.505960 0.296 0 0
Chromosome Maintenance R-HSA-73886 0.509873 0.293 0 0
Signaling by EGFR R-HSA-177929 0.510274 0.292 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.510274 0.292 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.513942 0.289 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.513942 0.289 0 0
Formation of axial mesoderm R-HSA-9796292 0.513942 0.289 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.513942 0.289 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 0.513942 0.289 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.513942 0.289 0 0
Diseases of nucleotide metabolism R-HSA-9735804 0.513942 0.289 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.513942 0.289 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 0.513942 0.289 0 0
Maturation of nucleoprotein R-HSA-9683610 0.513942 0.289 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 0.513942 0.289 0 0
Dual Incision in GG-NER R-HSA-5696400 0.519054 0.285 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 0.519054 0.285 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.519054 0.285 0 0
RAF activation R-HSA-5673000 0.519054 0.285 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.519054 0.285 0 0
Regulation of CDH1 Function R-HSA-9764561 0.520589 0.284 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.522945 0.282 0 0
ESR-mediated signaling R-HSA-8939211 0.529056 0.276 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.530515 0.275 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.530784 0.275 0 0
Host Interactions of HIV factors R-HSA-162909 0.531065 0.275 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.531914 0.274 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.531914 0.274 0 0
Removal of the Flap Intermediate R-HSA-69166 0.534148 0.272 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 0.534148 0.272 0 0
Retrograde neurotrophin signalling R-HSA-177504 0.534148 0.272 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.534148 0.272 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.534148 0.272 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 0.534148 0.272 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 0.534148 0.272 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.540856 0.267 0 0
Regulation of beta-cell development R-HSA-186712 0.540856 0.267 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.544538 0.264 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.547696 0.261 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.547696 0.261 0 0
Signaling by ERBB2 R-HSA-1227986 0.550803 0.259 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 0.553515 0.257 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.553515 0.257 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.553515 0.257 0 0
Translesion synthesis by REV1 R-HSA-110312 0.553515 0.257 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.553515 0.257 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 0.553515 0.257 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.553515 0.257 0 0
p38MAPK events R-HSA-171007 0.553515 0.257 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 0.553515 0.257 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 0.553515 0.257 0 0
Signaling by Activin R-HSA-1502540 0.553515 0.257 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 0.553515 0.257 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 0.553515 0.257 0 0
Protein methylation R-HSA-8876725 0.553515 0.257 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 0.553515 0.257 0 0
p75NTR signals via NF-kB R-HSA-193639 0.553515 0.257 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 0.553515 0.257 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.553521 0.257 0 0
Adherens junctions interactions R-HSA-418990 0.554864 0.256 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.556080 0.255 0 0
Voltage gated Potassium channels R-HSA-1296072 0.556922 0.254 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.556922 0.254 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.556922 0.254 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.556922 0.254 0 0
Degradation of DVL R-HSA-4641258 0.556922 0.254 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.556922 0.254 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.560912 0.251 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 0.569064 0.245 0 0
Potential therapeutics for SARS R-HSA-9679191 0.569699 0.244 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 0.572079 0.243 0 0
Translesion synthesis by POLI R-HSA-5656121 0.572079 0.243 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.572079 0.243 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.572079 0.243 0 0
Regulation of BACH1 activity R-HSA-9708530 0.572079 0.243 0 0
Killing mechanisms R-HSA-9664420 0.572079 0.243 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.572079 0.243 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.572079 0.243 0 0
Activation of SMO R-HSA-5635838 0.572079 0.243 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.572838 0.242 0 0
Stimuli-sensing channels R-HSA-2672351 0.575811 0.240 0 0
Semaphorin interactions R-HSA-373755 0.579864 0.237 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.579864 0.237 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.580964 0.236 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.580964 0.236 0 0
Stabilization of p53 R-HSA-69541 0.580964 0.236 0 0
Signaling by ALK R-HSA-201556 0.580964 0.236 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 0.589872 0.229 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.589872 0.229 0 0
Translesion synthesis by POLK R-HSA-5655862 0.589872 0.229 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.589872 0.229 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.589872 0.229 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 0.589872 0.229 0 0
Phase 2 - plateau phase R-HSA-5576893 0.589872 0.229 0 0
Response to metal ions R-HSA-5660526 0.589872 0.229 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.590340 0.229 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.590340 0.229 0 0
Attenuation phase R-HSA-3371568 0.592621 0.227 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.592621 0.227 0 0
ER-Phagosome pathway R-HSA-1236974 0.597176 0.224 0 0
Cellular response to hypoxia R-HSA-1234174 0.598566 0.223 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.600322 0.222 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.604033 0.219 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.604033 0.219 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.604033 0.219 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.604033 0.219 0 0
Inositol phosphate metabolism R-HSA-1483249 0.604592 0.219 0 0
Downstream TCR signaling R-HSA-202424 0.605102 0.218 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.606925 0.217 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.606925 0.217 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.606925 0.217 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.606925 0.217 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.606925 0.217 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.606925 0.217 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.606925 0.217 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 0.606925 0.217 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.606925 0.217 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 0.606925 0.217 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.615203 0.211 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.615203 0.211 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.615203 0.211 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.615203 0.211 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.615203 0.211 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.615203 0.211 0 0
DNA Double Strand Break Response R-HSA-5693606 0.616714 0.210 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.618145 0.209 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.623271 0.205 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.623271 0.205 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.623271 0.205 0 0
GAB1 signalosome R-HSA-180292 0.623271 0.205 0 0
Ephrin signaling R-HSA-3928664 0.623271 0.205 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.623271 0.205 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.623271 0.205 1 1
Mismatch Repair R-HSA-5358508 0.623271 0.205 0 0
Tie2 Signaling R-HSA-210993 0.623271 0.205 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.636812 0.196 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.636812 0.196 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.638938 0.195 0 0
Translesion Synthesis by POLH R-HSA-110320 0.638938 0.195 0 0
Regulation of signaling by CBL R-HSA-912631 0.638938 0.195 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.638938 0.195 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 0.638938 0.195 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.638938 0.195 0 0
Maturation of nucleoprotein R-HSA-9694631 0.638938 0.195 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 0.638938 0.195 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.643278 0.192 0 0
DNA Repair R-HSA-73894 0.645643 0.190 0 0
RMTs methylate histone arginines R-HSA-3214858 0.647255 0.189 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.650616 0.187 0 0
Mitochondrial biogenesis R-HSA-1592230 0.652161 0.186 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 0.653955 0.184 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.653955 0.184 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.653955 0.184 0 0
Signaling by NODAL R-HSA-1181150 0.653955 0.184 0 0
Creatine metabolism R-HSA-71288 0.653955 0.184 0 0
Protein hydroxylation R-HSA-9629569 0.653955 0.184 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.657458 0.182 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.657458 0.182 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.659609 0.181 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.665064 0.177 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.667424 0.176 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.667424 0.176 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.667424 0.176 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.668347 0.175 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.668347 0.175 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.668347 0.175 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.668347 0.175 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.668347 0.175 0 0
Lagging Strand Synthesis R-HSA-69186 0.668347 0.175 0 0
Signalling to RAS R-HSA-167044 0.668347 0.175 0 0
ERK/MAPK targets R-HSA-198753 0.668347 0.175 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.672381 0.172 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.677154 0.169 0 0
Synthesis of PC R-HSA-1483191 0.677154 0.169 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.682142 0.166 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.682142 0.166 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.682142 0.166 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 0.682142 0.166 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.682142 0.166 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.682142 0.166 0 0
FOXO-mediated transcription R-HSA-9614085 0.685777 0.164 1 0
NGF-stimulated transcription R-HSA-9031628 0.686651 0.163 0 0
UCH proteinases R-HSA-5689603 0.691350 0.160 0 0
Interleukin-12 signaling R-HSA-9020591 0.691350 0.160 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.695364 0.158 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.695364 0.158 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.695364 0.158 0 0
Ethanol oxidation R-HSA-71384 0.695364 0.158 0 0
mTORC1-mediated signalling R-HSA-166208 0.695364 0.158 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.698826 0.156 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.698928 0.156 0 0
PI3K Cascade R-HSA-109704 0.704957 0.152 0 0
Ub-specific processing proteases R-HSA-5689880 0.705359 0.152 0 0
PI Metabolism R-HSA-1483255 0.705642 0.151 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.707718 0.150 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.707718 0.150 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.707718 0.150 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 0.708037 0.150 0 0
Interleukin-20 family signaling R-HSA-8854691 0.708037 0.150 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 0.708037 0.150 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 0.708037 0.150 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 0.708037 0.150 0 0
Carnitine shuttle R-HSA-200425 0.708037 0.150 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.708037 0.150 0 0
Syndecan interactions R-HSA-3000170 0.708037 0.150 0 0
Cell-cell junction organization R-HSA-421270 0.712730 0.147 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.713770 0.146 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.713770 0.146 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.716420 0.145 0 0
Platelet degranulation R-HSA-114608 0.719181 0.143 0 0
Plasma lipoprotein assembly R-HSA-8963898 0.720183 0.143 0 0
Mitochondrial RNA degradation R-HSA-9836573 0.720183 0.143 0 0
Signaling by MET R-HSA-6806834 0.720812 0.142 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.722362 0.141 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.724791 0.140 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.727827 0.138 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.727827 0.138 0 0
Nucleotide Excision Repair R-HSA-5696398 0.730689 0.136 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.730736 0.136 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.730736 0.136 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.730736 0.136 0 0
Meiotic synapsis R-HSA-1221632 0.730736 0.136 0 0
Long-term potentiation R-HSA-9620244 0.731825 0.136 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.731825 0.136 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.731825 0.136 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.731825 0.136 0 0
HDMs demethylate histones R-HSA-3214842 0.731825 0.136 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.731825 0.136 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.731825 0.136 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 0.731825 0.136 0 0
Laminin interactions R-HSA-3000157 0.731825 0.136 0 0
Interleukin-7 signaling R-HSA-1266695 0.731825 0.136 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.735768 0.133 0 0
Programmed Cell Death R-HSA-5357801 0.737632 0.132 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.742983 0.129 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.742983 0.129 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.742983 0.129 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.742983 0.129 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.742983 0.129 0 0
Metalloprotease DUBs R-HSA-5689901 0.742983 0.129 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.742983 0.129 0 0
Urea cycle R-HSA-70635 0.742983 0.129 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.742983 0.129 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 0.742983 0.129 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.746839 0.127 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.748403 0.126 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.753677 0.123 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.753677 0.123 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.753677 0.123 0 0
Signaling by BMP R-HSA-201451 0.753677 0.123 0 0
Triglyceride biosynthesis R-HSA-75109 0.753677 0.123 0 0
Insulin processing R-HSA-264876 0.753677 0.123 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 0.753677 0.123 0 0
Synthesis of PE R-HSA-1483213 0.753677 0.123 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.754577 0.122 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.754577 0.122 0 0
Ion homeostasis R-HSA-5578775 0.754577 0.122 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.756758 0.121 0 0
TCR signaling R-HSA-202403 0.759708 0.119 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.759835 0.119 0 0
Developmental Cell Lineages R-HSA-9734767 0.760219 0.119 0 0
IRS-mediated signalling R-HSA-112399 0.762109 0.118 0 0
Synthesis of PA R-HSA-1483166 0.762109 0.118 0 0
HIV elongation arrest and recovery R-HSA-167287 0.763927 0.117 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.763927 0.117 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 0.763927 0.117 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.763927 0.117 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.763927 0.117 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.763927 0.117 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 0.763927 0.117 0 0
Muscle contraction R-HSA-397014 0.766979 0.115 0 0
Dual incision in TC-NER R-HSA-6782135 0.769441 0.114 0 0
Pyruvate metabolism R-HSA-70268 0.773103 0.112 0 0
Interleukin-12 family signaling R-HSA-447115 0.773103 0.112 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 0.773752 0.111 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 0.773752 0.111 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.773752 0.111 0 0
Apoptosis R-HSA-109581 0.774503 0.111 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.776475 0.110 0 0
Peroxisomal protein import R-HSA-9033241 0.776575 0.110 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.776575 0.110 0 0
Ion channel transport R-HSA-983712 0.778311 0.109 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.781133 0.107 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.783167 0.106 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.783167 0.106 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 0.783167 0.106 0 0
Neurotransmitter clearance R-HSA-112311 0.783167 0.106 0 0
Selenoamino acid metabolism R-HSA-2408522 0.783258 0.106 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.783935 0.106 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.790265 0.102 0 0
MAP kinase activation R-HSA-450294 0.790265 0.102 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.790265 0.102 0 0
Base Excision Repair R-HSA-73884 0.790530 0.102 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.792192 0.101 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.792192 0.101 0 0
Budding and maturation of HIV virion R-HSA-162588 0.792192 0.101 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.792192 0.101 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.792192 0.101 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.792192 0.101 0 0
Trafficking of AMPA receptors R-HSA-399719 0.792192 0.101 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 0.792192 0.101 0 0
Downstream signal transduction R-HSA-186763 0.792192 0.101 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.796829 0.099 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.796829 0.099 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.800841 0.096 0 0
DNA strand elongation R-HSA-69190 0.800841 0.096 0 0
Disease R-HSA-1643685 0.803447 0.095 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.809131 0.092 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.809131 0.092 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 0.809131 0.092 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.809131 0.092 0 0
Insulin receptor signalling cascade R-HSA-74751 0.809413 0.092 0 0
IGF1R signaling cascade R-HSA-2428924 0.809413 0.092 0 0
Ion transport by P-type ATPases R-HSA-936837 0.809413 0.092 0 0
Homology Directed Repair R-HSA-5693538 0.810395 0.091 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.812023 0.090 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.815441 0.089 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.815441 0.089 0 0
Striated Muscle Contraction R-HSA-390522 0.817077 0.088 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.817077 0.088 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.817077 0.088 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.817077 0.088 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.817077 0.088 0 0
Collagen formation R-HSA-1474290 0.817095 0.088 0 0
HIV Infection R-HSA-162906 0.821744 0.085 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.824692 0.084 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 0.824692 0.084 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.824692 0.084 0 0
Nuclear import of Rev protein R-HSA-180746 0.824692 0.084 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.824692 0.084 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.824692 0.084 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.824692 0.084 0 0
Signaling by NOTCH2 R-HSA-1980145 0.824692 0.084 0 0
Mitophagy R-HSA-5205647 0.824692 0.084 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 0.824692 0.084 0 0
Calnexin/calreticulin cycle R-HSA-901042 0.824692 0.084 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.825738 0.083 0 0
Kidney development R-HSA-9830369 0.826987 0.083 0 0
Signaling by Interleukins R-HSA-449147 0.829924 0.081 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.831990 0.080 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.831990 0.080 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.831990 0.080 0 0
Regulation of Apoptosis R-HSA-169911 0.831990 0.080 0 0
Oncogene Induced Senescence R-HSA-2559585 0.831990 0.080 0 0
PERK regulates gene expression R-HSA-381042 0.831990 0.080 0 0
Transferrin endocytosis and recycling R-HSA-917977 0.831990 0.080 0 0
Signalling to ERKs R-HSA-187687 0.831990 0.080 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 0.831990 0.080 0 0
Signaling by NTRKs R-HSA-166520 0.832108 0.080 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.832270 0.080 0 0
Regulated Necrosis R-HSA-5218859 0.832514 0.080 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.832514 0.080 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.836237 0.078 0 0
Formation of the cornified envelope R-HSA-6809371 0.836384 0.078 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.837880 0.077 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.838986 0.076 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.838986 0.076 0 0
RNA Polymerase III Transcription R-HSA-74158 0.838986 0.076 0 0
FLT3 signaling in disease R-HSA-9682385 0.838986 0.076 0 0
Calmodulin induced events R-HSA-111933 0.838986 0.076 0 0
CaM pathway R-HSA-111997 0.838986 0.076 0 0
GPVI-mediated activation cascade R-HSA-114604 0.838986 0.076 0 0
Hemostasis R-HSA-109582 0.839267 0.076 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.842757 0.074 0 0
Interleukin-17 signaling R-HSA-448424 0.843090 0.074 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.845690 0.073 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.845690 0.073 0 0
Degradation of AXIN R-HSA-4641257 0.845690 0.073 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.845690 0.073 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.848148 0.072 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.848148 0.072 0 0
ABC-family proteins mediated transport R-HSA-382556 0.849437 0.071 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.852115 0.070 0 0
MET promotes cell motility R-HSA-8875878 0.852115 0.070 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.852115 0.070 0 0
Purine salvage R-HSA-74217 0.852115 0.070 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.853627 0.069 0 0
Translation R-HSA-72766 0.858246 0.066 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.858274 0.066 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.858274 0.066 0 0
Pentose phosphate pathway R-HSA-71336 0.858274 0.066 0 0
RAS processing R-HSA-9648002 0.858274 0.066 0 0
Signaling by FGFR in disease R-HSA-1226099 0.862445 0.064 0 0
Signaling by ERBB4 R-HSA-1236394 0.862445 0.064 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.864142 0.063 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.864176 0.063 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.864176 0.063 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.864176 0.063 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.864176 0.063 0 0
HIV Transcription Elongation R-HSA-167169 0.864176 0.063 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.864176 0.063 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.864176 0.063 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.864176 0.063 0 0
Interleukin-2 family signaling R-HSA-451927 0.864176 0.063 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.865591 0.063 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.866930 0.062 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.866930 0.062 0 0
Cardiac conduction R-HSA-5576891 0.869733 0.061 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.869833 0.061 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.869833 0.061 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 0.869833 0.061 0 0
FLT3 Signaling R-HSA-9607240 0.869833 0.061 0 0
Signaling by TGFB family members R-HSA-9006936 0.872927 0.059 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.874802 0.058 0 0
MAP2K and MAPK activation R-HSA-5674135 0.875254 0.058 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.875254 0.058 0 0
Translation of Structural Proteins R-HSA-9683701 0.875254 0.058 0 0
Platelet homeostasis R-HSA-418346 0.876687 0.057 0 0
Integrin cell surface interactions R-HSA-216083 0.879590 0.056 0 0
ABC transporter disorders R-HSA-5619084 0.879590 0.056 0 0
Ca-dependent events R-HSA-111996 0.880450 0.055 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.880450 0.055 0 0
Depyrimidination R-HSA-73928 0.880450 0.055 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.880450 0.055 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 0.880450 0.055 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.882817 0.054 0 0
Sensory processing of sound R-HSA-9659379 0.883557 0.054 0 0
Defective pyroptosis R-HSA-9710421 0.885430 0.053 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.885430 0.053 0 0
Signaling by SCF-KIT R-HSA-1433557 0.885430 0.053 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.890203 0.051 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 0.890203 0.051 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.893417 0.049 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.894743 0.048 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.894777 0.048 0 0
Nucleosome assembly R-HSA-774815 0.894777 0.048 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.894777 0.048 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.894777 0.048 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.894777 0.048 0 0
DAG and IP3 signaling R-HSA-1489509 0.894777 0.048 0 0
Infectious disease R-HSA-5663205 0.897240 0.047 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.898244 0.047 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.898244 0.047 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.899161 0.046 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.899161 0.046 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.899161 0.046 0 0
Parasite infection R-HSA-9664407 0.899766 0.046 0 0
Leishmania phagocytosis R-HSA-9664417 0.899766 0.046 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.899766 0.046 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.902397 0.045 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.903362 0.044 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.903362 0.044 0 0
Co-stimulation by CD28 R-HSA-389356 0.907389 0.042 0 0
Plasma lipoprotein remodeling R-HSA-8963899 0.907389 0.042 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.908868 0.041 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.911248 0.040 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.912359 0.040 0 0
Azathioprine ADME R-HSA-9748787 0.914947 0.039 0 0
Phospholipid metabolism R-HSA-1483257 0.917710 0.037 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.921889 0.035 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.921889 0.035 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.921889 0.035 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.925144 0.034 0 0
Nucleotide biosynthesis R-HSA-8956320 0.925144 0.034 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.925144 0.034 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.928265 0.032 0 0
Signaling by Insulin receptor R-HSA-74752 0.930207 0.031 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.932587 0.030 0 0
Mitochondrial protein degradation R-HSA-9837999 0.934890 0.029 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.939500 0.027 0 0
Potassium Channels R-HSA-1296071 0.941359 0.026 0 0
Triglyceride metabolism R-HSA-8979227 0.942022 0.026 0 0
Amino acid transport across the plasma membrane R-HSA-352230 0.942022 0.026 0 0
RAB geranylgeranylation R-HSA-8873719 0.944440 0.025 0 0
Metabolism of polyamines R-HSA-351202 0.944440 0.025 0 0
Signaling by Retinoic Acid R-HSA-5362517 0.944440 0.025 0 0
tRNA Aminoacylation R-HSA-379724 0.944440 0.025 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.946757 0.024 0 0
PLC beta mediated events R-HSA-112043 0.946757 0.024 0 0
Nucleotide salvage R-HSA-8956321 0.946757 0.024 0 0
tRNA processing in the nucleus R-HSA-6784531 0.948977 0.023 0 0
Signaling by PDGF R-HSA-186797 0.948977 0.023 0 0
Complex I biogenesis R-HSA-6799198 0.951105 0.022 0 0
CD22 mediated BCR regulation R-HSA-5690714 0.953145 0.021 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.956734 0.019 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.958545 0.018 0 0
G-protein mediated events R-HSA-112040 0.958767 0.018 0 0
Nicotinate metabolism R-HSA-196807 0.958767 0.018 0 0
SLC-mediated transport of amino acids R-HSA-9958863 0.958767 0.018 0 0
Immune System R-HSA-168256 0.958851 0.018 0 0
Transcription of the HIV genome R-HSA-167172 0.960487 0.018 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.960487 0.018 0 0
Post-translational protein modification R-HSA-597592 0.960643 0.017 0 0
Gene Silencing by RNA R-HSA-211000 0.961621 0.017 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.963435 0.016 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.963571 0.016 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.963716 0.016 0 0
Metabolism of cofactors R-HSA-8978934 0.965230 0.015 0 0
ECM proteoglycans R-HSA-3000178 0.965230 0.015 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.965825 0.015 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.966681 0.015 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 0.966681 0.015 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.969404 0.013 0 0
Protein ubiquitination R-HSA-8852135 0.970681 0.013 0 0
Iron uptake and transport R-HSA-917937 0.970681 0.013 0 0
Parasitic Infection Pathways R-HSA-9824443 0.971430 0.013 0 0
Leishmania infection R-HSA-9658195 0.971430 0.013 0 0
Translation of Structural Proteins R-HSA-9694635 0.973077 0.012 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.973198 0.012 0 0
Interleukin-10 signaling R-HSA-6783783 0.974201 0.011 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.974201 0.011 0 0
PCP/CE pathway R-HSA-4086400 0.974201 0.011 0 0
Neddylation R-HSA-8951664 0.975443 0.011 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.976310 0.010 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.978441 0.009 0 0
HIV Life Cycle R-HSA-162587 0.978987 0.009 0 0
Extracellular matrix organization R-HSA-1474244 0.981734 0.008 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.982425 0.008 0 0
Neurotransmitter release cycle R-HSA-112310 0.985183 0.006 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.985542 0.006 0 0
Keratinization R-HSA-6805567 0.986493 0.006 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.986964 0.006 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.986964 0.006 0 0
FCGR activation R-HSA-2029481 0.987509 0.005 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.989470 0.005 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.990332 0.004 0 0
Glycolysis R-HSA-70171 0.991123 0.004 0 0
Opioid Signalling R-HSA-111885 0.992517 0.003 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.994107 0.003 0 0
Protein localization R-HSA-9609507 0.994325 0.002 0 0
HCMV Late Events R-HSA-9610379 0.995120 0.002 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.995519 0.002 0 0
Glucose metabolism R-HSA-70326 0.996224 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 0.996224 0.002 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.996354 0.002 0 0
SLC transporter disorders R-HSA-5619102 0.996660 0.001 0 0
Regulation of Complement cascade R-HSA-977606 0.997318 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.997538 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.998175 0.001 0 0
Diseases of glycosylation R-HSA-3781865 0.998323 0.001 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 0.998350 0.001 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.998408 0.001 0 0
Neutrophil degranulation R-HSA-6798695 0.998439 0.001 0 0
Integration of energy metabolism R-HSA-163685 0.998527 0.001 1 0
Metabolism of nucleotides R-HSA-15869 0.998716 0.001 0 0
Complement cascade R-HSA-166658 0.999040 0.000 0 0
Metabolism of proteins R-HSA-392499 0.999247 0.000 0 0
G alpha (q) signalling events R-HSA-416476 0.999534 0.000 0 0
Innate Immune System R-HSA-168249 0.999599 0.000 0 0
tRNA processing R-HSA-72306 0.999685 0.000 0 0
G alpha (s) signalling events R-HSA-418555 0.999698 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 0.999723 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 0.999723 0.000 0 0
Metabolism of steroids R-HSA-8957322 0.999734 0.000 0 0
Respiratory electron transport R-HSA-611105 0.999777 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.999796 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 0.999854 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 0.999885 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 0.999936 0.000 0 0
Drug ADME R-HSA-9748784 0.999962 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 0.999981 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 0.999987 0.000 0 0
GPCR downstream signalling R-HSA-388396 0.999989 0.000 0 0
Diseases of metabolism R-HSA-5668914 0.999994 0.000 0 0
Transport of small molecules R-HSA-382551 0.999995 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 0.999997 0.000 0 0
Signaling by GPCR R-HSA-372790 0.999999 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000 0.000 0 0
Biological oxidations R-HSA-211859 1.000000 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 1 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Apoptotic execution phase R-HSA-75153 1.332268e-15 14.875 0 0
Axon guidance R-HSA-422475 2.003242e-10 9.698 0 0
Cellular responses to stimuli R-HSA-8953897 2.056652e-10 9.687 0 0
Nervous system development R-HSA-9675108 7.438233e-10 9.129 0 0
Cellular responses to stress R-HSA-2262752 1.019616e-09 8.992 0 0
Apoptosis R-HSA-109581 1.614753e-09 8.792 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.745289e-09 8.171 0 0
Programmed Cell Death R-HSA-5357801 4.752952e-08 7.323 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.053785e-08 7.152 0 0
L1CAM interactions R-HSA-373760 9.521786e-08 7.021 0 0
Recycling pathway of L1 R-HSA-437239 4.511968e-07 6.346 0 0
Metabolism of RNA R-HSA-8953854 4.625031e-07 6.335 0 0
Cell Cycle R-HSA-1640170 4.706484e-07 6.327 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.849636e-07 6.233 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.229042e-07 6.206 0 0
Cell Cycle, Mitotic R-HSA-69278 1.025678e-06 5.989 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.418634e-06 5.848 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.403141e-06 5.853 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.478659e-06 5.830 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.878161e-06 5.726 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.322018e-06 5.634 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.322018e-06 5.634 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.322018e-06 5.634 0 0
Signaling by RAS mutants R-HSA-6802949 2.322018e-06 5.634 0 0
Post NMDA receptor activation events R-HSA-438064 2.124299e-06 5.673 0 0
Cell-Cell communication R-HSA-1500931 2.433017e-06 5.614 0 0
PKR-mediated signaling R-HSA-9833482 3.362601e-06 5.473 0 0
Signaling by VEGF R-HSA-194138 4.713941e-06 5.327 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.532755e-06 5.257 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.580164e-06 5.253 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.422036e-06 5.192 0 0
MTOR signalling R-HSA-165159 6.671867e-06 5.176 1 0
Interferon Signaling R-HSA-913531 7.247915e-06 5.140 0 0
Cell junction organization R-HSA-446728 1.163667e-05 4.934 0 0
Glycolysis R-HSA-70171 1.269013e-05 4.897 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.319652e-05 4.880 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.572458e-05 4.803 0 0
M Phase R-HSA-68886 1.644026e-05 4.784 0 0
EPH-Ephrin signaling R-HSA-2682334 1.870950e-05 4.728 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.925832e-05 4.715 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.936260e-05 4.713 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.101994e-05 4.677 0 0
Signal Transduction R-HSA-162582 2.320363e-05 4.634 1 0
Developmental Biology R-HSA-1266738 2.617192e-05 4.582 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.740520e-05 4.562 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.757862e-05 4.559 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.757862e-05 4.559 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.977526e-05 4.526 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.172114e-05 4.499 0 0
MAP2K and MAPK activation R-HSA-5674135 3.254592e-05 4.488 0 0
Signaling by Hippo R-HSA-2028269 3.298925e-05 4.482 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.298925e-05 4.482 0 0
G2/M Transition R-HSA-69275 3.192855e-05 4.496 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.678473e-05 4.434 0 0
Cellular response to heat stress R-HSA-3371556 3.710577e-05 4.431 0 0
mRNA Splicing R-HSA-72172 4.146650e-05 4.382 0 0
Interleukin-12 signaling R-HSA-9020591 3.980609e-05 4.400 0 0
Ephrin signaling R-HSA-3928664 4.354215e-05 4.361 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.289242e-05 4.368 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.354215e-05 4.361 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.434243e-05 4.353 0 0
Host Interactions of HIV factors R-HSA-162909 4.844059e-05 4.315 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.313612e-05 4.275 0 0
Mitotic Prometaphase R-HSA-68877 5.194515e-05 4.284 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.329583e-05 4.199 0 0
Regulation of CDH1 Function R-HSA-9764561 7.079643e-05 4.150 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.298322e-05 4.137 0 0
Autophagy R-HSA-9612973 8.665780e-05 4.062 0 0
Glucose metabolism R-HSA-70326 8.816607e-05 4.055 0 0
Gap junction trafficking and regulation R-HSA-157858 1.119198e-04 3.951 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.066621e-04 3.972 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.066621e-04 3.972 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.235875e-04 3.908 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.253749e-04 3.902 0 0
Aggrephagy R-HSA-9646399 1.283508e-04 3.892 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.480310e-04 3.830 0 0
Interleukin-12 family signaling R-HSA-447115 1.480310e-04 3.830 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.498967e-04 3.824 0 0
Semaphorin interactions R-HSA-373755 1.517167e-04 3.819 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.803794e-04 3.744 0 0
HIV Infection R-HSA-162906 1.715302e-04 3.766 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.743792e-04 3.759 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.905504e-04 3.720 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.348496e-04 3.629 0 0
Macroautophagy R-HSA-1632852 2.370942e-04 3.625 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.636105e-04 3.579 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.636105e-04 3.579 0 0
Cell-cell junction organization R-HSA-421270 2.584205e-04 3.588 0 0
Signaling by ROBO receptors R-HSA-376176 2.636588e-04 3.579 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.636768e-04 3.579 0 0
Protein folding R-HSA-391251 2.636768e-04 3.579 0 0
Gap junction trafficking R-HSA-190828 2.686112e-04 3.571 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.695394e-04 3.569 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.156793e-04 3.501 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.745066e-04 3.427 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.890832e-04 3.410 0 0
Metabolism of non-coding RNA R-HSA-194441 3.989357e-04 3.399 0 0
snRNP Assembly R-HSA-191859 3.989357e-04 3.399 0 0
Influenza Infection R-HSA-168255 4.279729e-04 3.369 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.499051e-04 3.347 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.817729e-04 3.317 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.888592e-04 3.311 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.571913e-04 3.254 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.574941e-04 3.254 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.682774e-04 3.245 1 0
Mitotic Anaphase R-HSA-68882 5.767176e-04 3.239 0 0
Selective autophagy R-HSA-9663891 5.802399e-04 3.236 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.081085e-04 3.216 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.485344e-04 3.188 1 1
Intracellular signaling by second messengers R-HSA-9006925 6.937279e-04 3.159 0 0
Adherens junctions interactions R-HSA-418990 6.409710e-04 3.193 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.598911e-04 3.119 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.713474e-04 3.060 0 0
Ca-dependent events R-HSA-111996 9.586077e-04 3.018 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.027701e-03 2.988 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.027701e-03 2.988 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.042955e-03 2.982 0 0
Mitotic Prophase R-HSA-68875 1.072965e-03 2.969 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.025638e-03 2.989 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.033615e-03 2.986 0 0
Separation of Sister Chromatids R-HSA-2467813 1.118955e-03 2.951 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.123091e-03 2.950 0 0
Cellular Senescence R-HSA-2559583 1.157109e-03 2.937 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.160826e-03 2.935 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.186823e-03 2.926 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.226375e-03 2.911 0 0
RAF activation R-HSA-5673000 1.364627e-03 2.865 0 0
Gap junction assembly R-HSA-190861 1.364627e-03 2.865 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.408577e-03 2.851 0 0
Signaling by ERBB2 R-HSA-1227986 1.740189e-03 2.759 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.740189e-03 2.759 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.744149e-03 2.758 0 0
Calmodulin induced events R-HSA-111933 1.782201e-03 2.749 0 0
CaM pathway R-HSA-111997 1.782201e-03 2.749 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.826906e-03 2.738 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.826906e-03 2.738 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.826906e-03 2.738 0 0
HIV Life Cycle R-HSA-162587 1.908296e-03 2.719 0 0
Co-stimulation by CD28 R-HSA-389356 1.939222e-03 2.712 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.025049e-03 2.694 0 0
Viral Infection Pathways R-HSA-9824446 2.222413e-03 2.653 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.292733e-03 2.640 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.365335e-03 2.626 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.586900e-03 2.587 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.392769e-03 2.621 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.586900e-03 2.587 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.818220e-03 2.550 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.901456e-03 2.537 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.909232e-03 2.536 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.909232e-03 2.536 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.909232e-03 2.536 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.929004e-03 2.533 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.139739e-03 2.503 0 0
Gene expression (Transcription) R-HSA-74160 3.274740e-03 2.485 1 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.325848e-03 2.478 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.325848e-03 2.478 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.353267e-03 2.475 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.367997e-03 2.473 0 0
MAPK family signaling cascades R-HSA-5683057 3.433376e-03 2.464 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.086905e-03 2.389 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.794803e-03 2.421 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.794803e-03 2.421 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.933999e-03 2.405 0 0
Cell Cycle Checkpoints R-HSA-69620 4.013605e-03 2.396 0 0
PTEN Regulation R-HSA-6807070 4.172113e-03 2.380 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.261722e-03 2.370 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.620502e-03 2.335 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.644805e-03 2.333 0 0
Platelet degranulation R-HSA-114608 4.811267e-03 2.318 0 0
FOXO-mediated transcription R-HSA-9614085 4.861657e-03 2.313 1 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.877369e-03 2.312 0 0
Integrin signaling R-HSA-354192 4.877369e-03 2.312 0 0
Cellular response to starvation R-HSA-9711097 4.911674e-03 2.309 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.002352e-03 2.301 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.162590e-03 2.287 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.214071e-03 2.283 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 6.232689e-03 2.205 0 0
Peptide chain elongation R-HSA-156902 5.771876e-03 2.239 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.450311e-03 2.264 0 0
HCMV Early Events R-HSA-9609690 5.925447e-03 2.227 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.896739e-03 2.229 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.232689e-03 2.205 0 0
DAG and IP3 signaling R-HSA-1489509 5.532789e-03 2.257 0 0
Nef and signal transduction R-HSA-164944 5.653553e-03 2.248 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.496493e-03 2.260 0 0
mTORC1-mediated signalling R-HSA-166208 5.397588e-03 2.268 0 0
Nuclear import of Rev protein R-HSA-180746 6.171188e-03 2.210 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.516976e-03 2.258 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 6.232689e-03 2.205 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.296070e-03 2.201 0 0
Manipulation of host energy metabolism R-HSA-9636667 6.421686e-03 2.192 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.664894e-03 2.176 0 0
PLC beta mediated events R-HSA-112043 6.664894e-03 2.176 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.713353e-03 2.173 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.713353e-03 2.173 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 6.904205e-03 2.161 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 7.145293e-03 2.146 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.145293e-03 2.146 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.145293e-03 2.146 0 0
Gluconeogenesis R-HSA-70263 7.369299e-03 2.133 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.698273e-03 2.114 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.836118e-03 2.106 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.836118e-03 2.106 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.071489e-03 2.093 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.071489e-03 2.093 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.509603e-03 2.070 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.509603e-03 2.070 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.509603e-03 2.070 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.112526e-02 1.954 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.112526e-02 1.954 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.112526e-02 1.954 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.112526e-02 1.954 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.112526e-02 1.954 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.112526e-02 1.954 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.112526e-02 1.954 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.112526e-02 1.954 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.112526e-02 1.954 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.112526e-02 1.954 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.112526e-02 1.954 0 0
mRNA 3'-end processing R-HSA-72187 1.047396e-02 1.980 0 0
AURKA Activation by TPX2 R-HSA-8854518 9.874285e-03 2.005 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.032310e-02 1.986 0 0
HSF1-dependent transactivation R-HSA-3371571 9.621986e-03 2.017 0 0
G-protein mediated events R-HSA-112040 1.063407e-02 1.973 0 0
Cilium Assembly R-HSA-5617833 9.895494e-03 2.005 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.048362e-02 1.979 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.047367e-02 1.980 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.275863e-03 2.033 0 0
Signaling by Interleukins R-HSA-449147 1.005995e-02 1.997 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.124326e-02 1.949 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.124326e-02 1.949 0 0
Smooth Muscle Contraction R-HSA-445355 1.137949e-02 1.944 0 0
Cellular response to chemical stress R-HSA-9711123 1.160182e-02 1.935 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.172482e-02 1.931 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.174576e-02 1.930 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.217207e-02 1.915 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.229423e-02 1.910 0 0
Regulation of TP53 Activity R-HSA-5633007 1.230266e-02 1.910 1 0
Translation initiation complex formation R-HSA-72649 1.234039e-02 1.909 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.234858e-02 1.908 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.267775e-02 1.897 0 0
Translation R-HSA-72766 1.298325e-02 1.887 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.317327e-02 1.880 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.358843e-02 1.867 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.443527e-02 1.841 0 0
Signaling by EGFR R-HSA-177929 1.443527e-02 1.841 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.461636e-02 1.835 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.694148e-02 1.771 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.843808e-02 1.734 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.612978e-02 1.792 0 0
Centrosome maturation R-HSA-380287 1.834968e-02 1.736 0 0
Neutrophil degranulation R-HSA-6798695 1.575631e-02 1.803 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.797299e-02 1.745 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.509576e-02 1.821 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.509576e-02 1.821 0 0
G1 Phase R-HSA-69236 1.802420e-02 1.744 0 0
Cyclin D associated events in G1 R-HSA-69231 1.802420e-02 1.744 0 0
Trafficking of AMPA receptors R-HSA-399719 1.638532e-02 1.786 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.519013e-02 1.818 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.509576e-02 1.821 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.488548e-02 1.827 0 0
ESR-mediated signaling R-HSA-8939211 1.488390e-02 1.827 0 0
Signal transduction by L1 R-HSA-445144 1.785514e-02 1.748 0 0
RNA Polymerase II Transcription R-HSA-73857 1.604122e-02 1.795 1 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.557271e-02 1.808 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.843808e-02 1.734 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.843808e-02 1.734 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.818013e-02 1.740 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.896541e-02 1.722 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.899468e-02 1.721 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.902749e-02 1.721 0 0
Transmission across Chemical Synapses R-HSA-112315 1.904422e-02 1.720 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.936494e-02 1.713 0 0
Kinesins R-HSA-983189 1.936494e-02 1.713 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.946156e-02 1.711 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.956971e-02 1.708 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.956971e-02 1.708 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.987789e-02 1.702 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.002707e-02 1.698 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.012613e-02 1.696 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.026747e-02 1.693 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.076097e-02 1.683 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.120305e-02 1.674 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.120305e-02 1.674 0 0
Ribosome-associated quality control R-HSA-9948299 2.169511e-02 1.664 0 0
Striated Muscle Contraction R-HSA-390522 2.203142e-02 1.657 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.203142e-02 1.657 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.207734e-02 1.656 0 0
tRNA processing in the nucleus R-HSA-6784531 2.222551e-02 1.653 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.259758e-02 1.646 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.287096e-02 1.641 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.287096e-02 1.641 0 0
HCMV Infection R-HSA-9609646 2.293253e-02 1.640 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.376001e-02 1.624 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.377784e-02 1.624 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.377784e-02 1.624 0 0
MTF1 activates gene expression R-HSA-5660489 2.377784e-02 1.624 0 0
Intraflagellar transport R-HSA-5620924 2.474100e-02 1.607 0 0
G1/S Transition R-HSA-69206 2.478721e-02 1.606 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.498061e-02 1.602 0 0
FGFR2 alternative splicing R-HSA-6803529 2.566877e-02 1.591 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.599992e-02 1.585 0 0
Pervasive developmental disorders R-HSA-9005895 2.599992e-02 1.585 0 0
Disorders of Nervous System Development R-HSA-9697154 2.599992e-02 1.585 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.599992e-02 1.585 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.631369e-02 1.580 0 0
Eukaryotic Translation Termination R-HSA-72764 2.631369e-02 1.580 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.764932e-02 1.558 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.769628e-02 1.558 0 0
Syndecan interactions R-HSA-3000170 2.866349e-02 1.543 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.031374e-02 1.518 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.031374e-02 1.518 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.031374e-02 1.518 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.062486e-02 1.514 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.133015e-02 1.504 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.154731e-02 1.501 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.016801e-02 1.396 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 4.016801e-02 1.396 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.016801e-02 1.396 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.497986e-02 1.456 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.264404e-02 1.370 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.295088e-02 1.482 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.524851e-02 1.453 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.456478e-02 1.461 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.456478e-02 1.461 0 0
Viral mRNA Translation R-HSA-192823 3.882669e-02 1.411 0 0
Myogenesis R-HSA-525793 3.884674e-02 1.411 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.016801e-02 1.396 0 0
Regulation of KIT signaling R-HSA-1433559 3.497986e-02 1.456 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.999416e-02 1.398 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.640425e-02 1.439 1 1
Malate-aspartate shuttle R-HSA-9856872 3.497986e-02 1.456 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.263028e-02 1.370 0 0
Opioid Signalling R-HSA-111885 4.063291e-02 1.391 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 4.274969e-02 1.369 0 0
Membrane Trafficking R-HSA-199991 3.818579e-02 1.418 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.701984e-02 1.432 0 0
Selenocysteine synthesis R-HSA-2408557 3.537979e-02 1.451 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.278933e-02 1.484 0 0
Hedgehog 'off' state R-HSA-5610787 3.373780e-02 1.472 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.016801e-02 1.396 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.661936e-02 1.436 0 0
FLT3 Signaling R-HSA-9607240 4.276905e-02 1.369 0 0
Muscle contraction R-HSA-397014 4.425735e-02 1.354 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.597296e-02 1.337 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.638989e-02 1.334 0 0
Infectious disease R-HSA-5663205 4.712440e-02 1.327 0 0
Gene Silencing by RNA R-HSA-211000 4.842348e-02 1.315 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.907272e-02 1.309 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 4.956300e-02 1.305 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.084340e-02 1.294 0 0
Disorders of Developmental Biology R-HSA-9675151 5.104423e-02 1.292 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.484232e-02 1.261 0 0
Activation of BH3-only proteins R-HSA-114452 5.524393e-02 1.258 0 0
PCP/CE pathway R-HSA-4086400 5.598073e-02 1.252 0 0
Netrin-1 signaling R-HSA-373752 5.642077e-02 1.249 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.706568e-02 1.244 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.706568e-02 1.244 0 0
G2/M Checkpoints R-HSA-69481 5.731346e-02 1.242 0 0
Developmental Cell Lineages R-HSA-9734767 5.895384e-02 1.229 0 0
Selenoamino acid metabolism R-HSA-2408522 5.955691e-02 1.225 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.965997e-02 1.224 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.965997e-02 1.224 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.965997e-02 1.224 0 0
Disinhibition of SNARE formation R-HSA-114516 5.965997e-02 1.224 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 5.965997e-02 1.224 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.965997e-02 1.224 0 0
Generic Transcription Pathway R-HSA-212436 6.194912e-02 1.208 1 0
Immune System R-HSA-168256 6.308107e-02 1.200 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.340691e-02 1.198 0 0
GAB1 signalosome R-HSA-180292 6.340691e-02 1.198 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.340691e-02 1.198 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.408342e-02 1.193 0 0
Signaling by TGFBR3 R-HSA-9839373 6.408342e-02 1.193 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.645122e-02 1.177 0 0
S Phase R-HSA-69242 6.724658e-02 1.172 0 0
G-protein beta:gamma signalling R-HSA-397795 6.963058e-02 1.157 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.963058e-02 1.157 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.963058e-02 1.157 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.963058e-02 1.157 0 0
Type I hemidesmosome assembly R-HSA-446107 7.039103e-02 1.152 0 0
Formation of annular gap junctions R-HSA-196025 7.039103e-02 1.152 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.039103e-02 1.152 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.039103e-02 1.152 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.039103e-02 1.152 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.407100e-02 1.130 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.506580e-02 1.125 0 0
SARS-CoV Infections R-HSA-9679506 7.553095e-02 1.122 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 7.561236e-02 1.121 0 0
Inhibition of PKR R-HSA-169131 7.561236e-02 1.121 0 0
Degradation of CDH1 R-HSA-9766229 7.661557e-02 1.116 0 0
Formation of definitive endoderm R-HSA-9823730 7.701053e-02 1.113 0 0
Nephrin family interactions R-HSA-373753 7.701053e-02 1.113 0 0
rRNA processing R-HSA-72312 7.703788e-02 1.113 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 1.112500e-01 0.954 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.112500e-01 0.954 0 0
Lipophagy R-HSA-9613354 8.169246e-02 1.088 0 0
Gap junction degradation R-HSA-190873 8.169246e-02 1.088 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 9.350449e-02 1.029 0 0
Binding and entry of HIV virion R-HSA-173107 9.350449e-02 1.029 0 0
Folding of actin by CCT/TriC R-HSA-390450 9.350449e-02 1.029 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.057711e-01 0.976 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.425221e-02 1.074 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.425221e-02 1.074 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 1.076023e-01 0.968 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 1.076023e-01 0.968 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.158878e-01 0.936 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.097594e-01 0.960 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.029549e-01 0.987 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 9.350449e-02 1.029 0 0
Regulation of CDH11 function R-HSA-9762292 9.350449e-02 1.029 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.169246e-02 1.088 1 1
TRAF6 mediated NF-kB activation R-HSA-933542 1.158878e-01 0.936 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 1.097594e-01 0.960 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.815923e-02 1.008 0 0
HSF1 activation R-HSA-3371511 9.148457e-02 1.039 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.075656e-01 0.968 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 8.169246e-02 1.088 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.018599e-02 1.096 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.316656e-02 1.080 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.755122e-02 1.058 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.112500e-01 0.954 0 0
Unwinding of DNA R-HSA-176974 8.169246e-02 1.088 0 0
Orc1 removal from chromatin R-HSA-68949 9.037084e-02 1.044 0 0
TCR signaling R-HSA-202403 1.121242e-01 0.950 0 0
Chromatin organization R-HSA-4839726 1.149614e-01 0.939 0 0
PERK regulates gene expression R-HSA-381042 8.574414e-02 1.067 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.755122e-02 1.058 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.574414e-02 1.067 0 0
G alpha (z) signalling events R-HSA-418597 1.053102e-01 0.978 0 0
Chromatin modifying enzymes R-HSA-3247509 8.100850e-02 1.091 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.112500e-01 0.954 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.169246e-02 1.088 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.955976e-02 1.002 0 0
MHC class II antigen presentation R-HSA-2132295 9.527223e-02 1.021 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.116583e-02 1.091 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 8.169246e-02 1.088 0 0
PECAM1 interactions R-HSA-210990 1.057711e-01 0.976 0 0
Neuronal System R-HSA-112316 7.766920e-02 1.110 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.158878e-01 0.936 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.441740e-02 1.025 0 0
FLT3 signaling in disease R-HSA-9682385 9.148457e-02 1.039 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 9.350449e-02 1.029 0 0
Bicarbonate transporters R-HSA-425381 1.057711e-01 0.976 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.076023e-01 0.968 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.177246e-02 1.037 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 9.350449e-02 1.029 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 9.955976e-02 1.002 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 8.169246e-02 1.088 0 0
Signaling by NOTCH4 R-HSA-9013694 1.075656e-01 0.968 0 0
Signaling by NOTCH3 R-HSA-9012852 1.053102e-01 0.978 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.152653e-01 0.938 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.522139e-02 1.021 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.315650e-02 1.080 0 0
Signaling by Hedgehog R-HSA-5358351 8.945922e-02 1.048 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.177246e-02 1.037 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.105445e-01 0.956 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.650949e-02 1.015 0 0
HIV Transcription Elongation R-HSA-167169 1.161876e-01 0.935 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.161876e-01 0.935 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.161876e-01 0.935 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.161876e-01 0.935 0 0
Attenuation phase R-HSA-3371568 1.161876e-01 0.935 0 0
Generation of second messenger molecules R-HSA-202433 1.161876e-01 0.935 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.184399e-01 0.927 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.184399e-01 0.927 0 0
Integration of provirus R-HSA-162592 1.184399e-01 0.927 0 0
Activation of RAC1 R-HSA-428540 1.184399e-01 0.927 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.184399e-01 0.927 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.227763e-01 0.911 0 0
Signaling by NTRKs R-HSA-166520 1.236909e-01 0.908 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.244043e-01 0.905 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.244043e-01 0.905 0 0
Long-term potentiation R-HSA-9620244 1.244043e-01 0.905 0 0
Tight junction interactions R-HSA-420029 1.244043e-01 0.905 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.244043e-01 0.905 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.244043e-01 0.905 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.269796e-01 0.896 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.276831e-01 0.894 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.314616e-01 0.881 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.314616e-01 0.881 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.314616e-01 0.881 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.314616e-01 0.881 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.314616e-01 0.881 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.314616e-01 0.881 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.325491e-01 0.878 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.331391e-01 0.876 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.331391e-01 0.876 0 0
Circadian clock R-HSA-9909396 1.335542e-01 0.874 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.356636e-01 0.868 0 0
Signaling by FGFR2 R-HSA-5654738 1.364966e-01 0.865 0 0
MAP kinase activation R-HSA-450294 1.385213e-01 0.858 0 0
Interferon alpha/beta signaling R-HSA-909733 1.400486e-01 0.854 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.455158e-01 0.837 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.455158e-01 0.837 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 1.455158e-01 0.837 0 0
Potassium transport channels R-HSA-1296067 1.455158e-01 0.837 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 1.455158e-01 0.837 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.455158e-01 0.837 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.784625e-01 0.748 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.101408e-01 0.677 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.101408e-01 0.677 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.101408e-01 0.677 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.101408e-01 0.677 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.101408e-01 0.677 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.101408e-01 0.677 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.101408e-01 0.677 0 0
IRS activation R-HSA-74713 2.405995e-01 0.619 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.405995e-01 0.619 0 0
G2 Phase R-HSA-68911 2.405995e-01 0.619 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.405995e-01 0.619 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.405995e-01 0.619 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.405995e-01 0.619 0 0
Plus-strand DNA synthesis R-HSA-164525 2.698854e-01 0.569 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 2.698854e-01 0.569 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.698854e-01 0.569 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.698854e-01 0.569 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.698854e-01 0.569 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.698854e-01 0.569 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.447905e-01 0.839 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.722006e-01 0.764 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.722006e-01 0.764 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.420799e-01 0.847 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.420799e-01 0.847 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.420799e-01 0.847 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.512142e-01 0.820 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.512142e-01 0.820 0 0
HIV elongation arrest and recovery R-HSA-167287 1.512142e-01 0.820 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.512142e-01 0.820 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.289994e-01 0.640 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.434248e-01 0.614 0 0
EGFR downregulation R-HSA-182971 1.796537e-01 0.746 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.796537e-01 0.746 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.578854e-01 0.589 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.723571e-01 0.565 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.653887e-01 0.781 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.806348e-01 0.743 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.205941e-01 0.656 0 0
HDACs deacetylate histones R-HSA-3214815 2.371926e-01 0.625 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.743130e-01 0.759 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.456003e-01 0.610 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.626040e-01 0.581 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.302908e-01 0.638 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.798211e-01 0.553 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.608965e-01 0.793 0 0
mRNA Capping R-HSA-72086 1.605295e-01 0.794 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.529886e-01 0.815 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.700134e-01 0.770 0 0
Activation of the pre-replicative complex R-HSA-68962 1.700134e-01 0.770 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.605295e-01 0.794 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.195376e-01 0.658 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.506337e-01 0.822 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.023726e-01 0.694 0 0
DCC mediated attractive signaling R-HSA-418885 1.722006e-01 0.764 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.700134e-01 0.770 0 0
Meiotic synapsis R-HSA-1221632 2.205941e-01 0.656 0 0
UCH proteinases R-HSA-5689603 2.374393e-01 0.624 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.405995e-01 0.619 0 0
Regulation of Apoptosis R-HSA-169911 2.297810e-01 0.639 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.195376e-01 0.658 0 0
Regulation of gap junction activity R-HSA-191650 2.101408e-01 0.677 0 0
Formation of axial mesoderm R-HSA-9796292 1.447905e-01 0.839 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.003601e-01 0.698 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.401107e-01 0.620 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.820810e-01 0.550 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.955797e-01 0.709 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.420799e-01 0.847 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.578854e-01 0.589 0 0
Degradation of DVL R-HSA-4641258 2.505159e-01 0.601 0 0
DNA Double Strand Break Response R-HSA-5693606 1.757046e-01 0.755 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.150690e-01 0.667 0 0
Activation of AKT2 R-HSA-165158 2.405995e-01 0.619 0 0
Negative regulation of MET activity R-HSA-6807004 2.578854e-01 0.589 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.769784e-01 0.752 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.862044e-01 0.730 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.698854e-01 0.569 0 0
p38MAPK events R-HSA-171007 1.722006e-01 0.764 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.146351e-01 0.668 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.820810e-01 0.550 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.711887e-01 0.567 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.578854e-01 0.589 0 0
Signaling by SCF-KIT R-HSA-1433557 1.434545e-01 0.843 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.420799e-01 0.847 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.434248e-01 0.614 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.003601e-01 0.698 0 0
Signaling by WNT R-HSA-195721 2.735438e-01 0.563 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 1.455158e-01 0.837 0 0
PKB-mediated events R-HSA-109703 2.698854e-01 0.569 0 0
PDE3B signalling R-HSA-165160 2.698854e-01 0.569 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.698854e-01 0.569 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.146351e-01 0.668 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.434248e-01 0.614 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.161895e-01 0.665 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.232064e-01 0.651 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.447905e-01 0.839 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.862044e-01 0.730 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.124149e-01 0.673 0 0
G alpha (12/13) signalling events R-HSA-416482 2.519139e-01 0.599 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.605295e-01 0.794 0 0
The NLRP3 inflammasome R-HSA-844456 2.434248e-01 0.614 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.124149e-01 0.673 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.573457e-01 0.589 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.722006e-01 0.764 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.993548e-01 0.700 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.713921e-01 0.566 0 0
Intracellular oxygen transport R-HSA-8981607 1.784625e-01 0.748 0 0
NADE modulates death signalling R-HSA-205025 2.101408e-01 0.677 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.101408e-01 0.677 0 0
Protein methylation R-HSA-8876725 1.722006e-01 0.764 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.700134e-01 0.770 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.796537e-01 0.746 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.288552e-01 0.640 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.820810e-01 0.550 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.713921e-01 0.566 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.538869e-01 0.595 0 0
Vesicle-mediated transport R-HSA-5653656 2.365491e-01 0.626 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.579470e-01 0.801 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.715112e-01 0.566 0 0
Signalling to RAS R-HSA-167044 2.723571e-01 0.565 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.505159e-01 0.601 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.722006e-01 0.764 0 0
ERK/MAPK targets R-HSA-198753 2.723571e-01 0.565 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.306100e-01 0.637 0 0
Signaling by TGFB family members R-HSA-9006936 2.697985e-01 0.569 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.434248e-01 0.614 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.297810e-01 0.639 0 0
Interleukin-17 signaling R-HSA-448424 1.955797e-01 0.709 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.559921e-01 0.807 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.289994e-01 0.640 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.955797e-01 0.709 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.538510e-01 0.595 0 0
Platelet sensitization by LDL R-HSA-432142 2.289994e-01 0.640 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.993548e-01 0.700 0 0
Signalling to ERKs R-HSA-187687 2.297810e-01 0.639 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 1.455158e-01 0.837 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.698854e-01 0.569 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.447905e-01 0.839 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.722006e-01 0.764 0 0
DNA strand elongation R-HSA-69190 1.894381e-01 0.723 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.894381e-01 0.723 0 0
Stabilization of p53 R-HSA-69541 2.715112e-01 0.566 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.715112e-01 0.566 0 0
Rab regulation of trafficking R-HSA-9007101 2.594690e-01 0.586 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.447905e-01 0.839 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 2.798211e-01 0.553 0 0
Sensory processing of sound R-HSA-9659379 2.592328e-01 0.586 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.058468e-01 0.686 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.003601e-01 0.698 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.822422e-01 0.739 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.603982e-01 0.584 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.603982e-01 0.584 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.603982e-01 0.584 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.475158e-01 0.831 0 0
Potential therapeutics for SARS R-HSA-9679191 2.200342e-01 0.658 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.289994e-01 0.640 1 1
Signaling by NOTCH R-HSA-157118 2.283477e-01 0.641 0 0
Signaling by FGFR R-HSA-190236 1.417055e-01 0.849 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.820810e-01 0.550 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.003601e-01 0.698 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.723571e-01 0.565 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.917193e-01 0.717 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.657358e-01 0.781 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.093918e-01 0.679 0 0
Specification of primordial germ cells R-HSA-9827857 2.146351e-01 0.668 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.434248e-01 0.614 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.092437e-01 0.679 0 0
Signal regulatory protein family interactions R-HSA-391160 1.583835e-01 0.800 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 2.628056e-01 0.580 0 0
Signaling by ALK in cancer R-HSA-9700206 1.917193e-01 0.717 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.609862e-01 0.583 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.605295e-01 0.794 0 0
RET signaling R-HSA-8853659 2.401107e-01 0.620 0 0
Response to metal ions R-HSA-5660526 2.003601e-01 0.698 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.372126e-01 0.625 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.456003e-01 0.610 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 2.715112e-01 0.566 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.834570e-01 0.548 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.868175e-01 0.542 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.868175e-01 0.542 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.868175e-01 0.542 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.895381e-01 0.538 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.895381e-01 0.538 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.926859e-01 0.534 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.926859e-01 0.534 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.972077e-01 0.527 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.980435e-01 0.526 0 0
Signaling by LTK in cancer R-HSA-9842640 2.980435e-01 0.526 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.980435e-01 0.526 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.980435e-01 0.526 0 0
Uncoating of the HIV Virion R-HSA-162585 2.980435e-01 0.526 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.980435e-01 0.526 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.980435e-01 0.526 0 0
CREB phosphorylation R-HSA-199920 2.980435e-01 0.526 0 0
VLDL assembly R-HSA-8866423 2.980435e-01 0.526 0 0
Leukotriene receptors R-HSA-391906 2.980435e-01 0.526 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.033166e-01 0.518 0 0
HIV Transcription Initiation R-HSA-167161 3.033166e-01 0.518 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.033166e-01 0.518 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.033166e-01 0.518 0 0
Meiosis R-HSA-1500620 3.040665e-01 0.517 0 0
Signaling by PTK6 R-HSA-8848021 3.059511e-01 0.514 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.059511e-01 0.514 0 0
Innate Immune System R-HSA-168249 3.059953e-01 0.514 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.116594e-01 0.506 0 0
Nucleotide Excision Repair R-HSA-5696398 3.138500e-01 0.503 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.138500e-01 0.503 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 3.139641e-01 0.503 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.139641e-01 0.503 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.156237e-01 0.501 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.246197e-01 0.489 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.246197e-01 0.489 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.246197e-01 0.489 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.251174e-01 0.488 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.251174e-01 0.488 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.251174e-01 0.488 0 0
SOS-mediated signalling R-HSA-112412 3.251174e-01 0.488 0 0
Recycling of eIF2:GDP R-HSA-72731 3.251174e-01 0.488 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.251174e-01 0.488 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.251174e-01 0.488 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.251174e-01 0.488 0 0
LDL remodeling R-HSA-8964041 3.251174e-01 0.488 0 0
Netrin mediated repulsion signals R-HSA-418886 3.251174e-01 0.488 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.251174e-01 0.488 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.251174e-01 0.488 0 0
CHL1 interactions R-HSA-447041 3.251174e-01 0.488 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.251174e-01 0.488 0 0
Synthesis of DNA R-HSA-69239 3.275008e-01 0.485 0 0
tRNA processing R-HSA-72306 3.279098e-01 0.484 0 0
Deadenylation of mRNA R-HSA-429947 3.299330e-01 0.482 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.299330e-01 0.482 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.299330e-01 0.482 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.299330e-01 0.482 0 0
Neurodegenerative Diseases R-HSA-8863678 3.299330e-01 0.482 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.299330e-01 0.482 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.323198e-01 0.478 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.343561e-01 0.476 0 0
Proteasome assembly R-HSA-9907900 3.352749e-01 0.475 0 0
RMTs methylate histone arginines R-HSA-3214858 3.352749e-01 0.475 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.412281e-01 0.467 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.412281e-01 0.467 0 0
ER-Phagosome pathway R-HSA-1236974 3.422505e-01 0.466 0 0
TGFBR3 expression R-HSA-9839394 3.441579e-01 0.463 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.441579e-01 0.463 0 0
HDMs demethylate histones R-HSA-3214842 3.441579e-01 0.463 0 0
Interleukin-7 signaling R-HSA-1266695 3.441579e-01 0.463 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 3.441579e-01 0.463 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.459218e-01 0.461 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.459218e-01 0.461 0 0
Somitogenesis R-HSA-9824272 3.459218e-01 0.461 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.459218e-01 0.461 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.459218e-01 0.461 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.481145e-01 0.458 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.481145e-01 0.458 0 0
Transcription of the HIV genome R-HSA-167172 3.499646e-01 0.456 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.499646e-01 0.456 0 0
Reverse Transcription of HIV RNA R-HSA-162589 3.511487e-01 0.455 0 0
Minus-strand DNA synthesis R-HSA-164516 3.511487e-01 0.455 0 0
phospho-PLA2 pathway R-HSA-111995 3.511487e-01 0.455 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.511487e-01 0.455 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.511487e-01 0.455 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.511487e-01 0.455 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.511487e-01 0.455 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.511487e-01 0.455 0 0
FGFR1b ligand binding and activation R-HSA-190370 3.511487e-01 0.455 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.511487e-01 0.455 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.511487e-01 0.455 0 0
Adrenoceptors R-HSA-390696 3.511487e-01 0.455 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.511487e-01 0.455 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.511487e-01 0.455 0 0
Interleukin-23 signaling R-HSA-9020933 3.511487e-01 0.455 0 0
Reproduction R-HSA-1474165 3.516929e-01 0.454 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.582837e-01 0.446 0 0
MET activates PTK2 signaling R-HSA-8874081 3.582837e-01 0.446 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.582837e-01 0.446 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.582837e-01 0.446 0 0
Hemostasis R-HSA-109582 3.584536e-01 0.446 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.587923e-01 0.445 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.597065e-01 0.444 0 0
Inositol phosphate metabolism R-HSA-1483249 3.619212e-01 0.441 0 0
IRE1alpha activates chaperones R-HSA-381070 3.653329e-01 0.437 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.676175e-01 0.435 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.688369e-01 0.433 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 3.722967e-01 0.429 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.722967e-01 0.429 0 0
WNT mediated activation of DVL R-HSA-201688 3.761774e-01 0.425 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.761774e-01 0.425 0 0
Regulation of signaling by NODAL R-HSA-1433617 3.761774e-01 0.425 0 0
Calcineurin activates NFAT R-HSA-2025928 3.761774e-01 0.425 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.761774e-01 0.425 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.761774e-01 0.425 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.761774e-01 0.425 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.761774e-01 0.425 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.761774e-01 0.425 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.761774e-01 0.425 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.764358e-01 0.424 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.764358e-01 0.424 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.764358e-01 0.424 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.777364e-01 0.423 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.807403e-01 0.419 0 0
Telomere Extension By Telomerase R-HSA-171319 3.861848e-01 0.413 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.861848e-01 0.413 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.861848e-01 0.413 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 3.861848e-01 0.413 0 0
Inflammasomes R-HSA-622312 3.861848e-01 0.413 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.861848e-01 0.413 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.896068e-01 0.409 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.940343e-01 0.404 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.961349e-01 0.402 0 0
Late endosomal microautophagy R-HSA-9615710 3.999368e-01 0.398 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.999368e-01 0.398 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.002421e-01 0.398 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.002421e-01 0.398 0 0
PI3K/AKT activation R-HSA-198203 4.002421e-01 0.398 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.002421e-01 0.398 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.002421e-01 0.398 0 0
Signal attenuation R-HSA-74749 4.002421e-01 0.398 0 0
2-LTR circle formation R-HSA-164843 4.002421e-01 0.398 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.002421e-01 0.398 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.002421e-01 0.398 0 0
Signaling by Leptin R-HSA-2586552 4.002421e-01 0.398 0 0
Signaling by FGFR in disease R-HSA-1226099 4.028063e-01 0.395 0 0
Signaling by ERBB4 R-HSA-1236394 4.028063e-01 0.395 0 0
Extracellular matrix organization R-HSA-1474244 4.078816e-01 0.389 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.092162e-01 0.388 0 0
Protein ubiquitination R-HSA-8852135 4.115549e-01 0.386 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 4.135424e-01 0.383 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.135424e-01 0.383 0 0
Telomere Maintenance R-HSA-157579 4.191532e-01 0.378 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.196056e-01 0.377 0 0
Neurexins and neuroligins R-HSA-6794361 4.196056e-01 0.377 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.196056e-01 0.377 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.196056e-01 0.377 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.202763e-01 0.376 0 0
Leishmania phagocytosis R-HSA-9664417 4.213690e-01 0.375 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.213690e-01 0.375 0 0
Parasite infection R-HSA-9664407 4.213690e-01 0.375 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.233799e-01 0.373 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.233799e-01 0.373 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.233799e-01 0.373 0 0
Conjugation of benzoate with glycine R-HSA-177135 4.233799e-01 0.373 0 0
Signaling by APC mutants R-HSA-4839744 4.233799e-01 0.373 0 0
vRNP Assembly R-HSA-192905 4.233799e-01 0.373 0 0
Chylomicron assembly R-HSA-8963888 4.233799e-01 0.373 0 0
Synthesis of PI R-HSA-1483226 4.233799e-01 0.373 0 0
Suppression of apoptosis R-HSA-9635465 4.233799e-01 0.373 0 0
Post-translational protein phosphorylation R-HSA-8957275 4.267955e-01 0.370 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.269926e-01 0.370 0 0
Budding and maturation of HIV virion R-HSA-162588 4.269926e-01 0.370 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.299335e-01 0.367 0 0
Amino acids regulate mTORC1 R-HSA-9639288 4.299335e-01 0.367 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.299335e-01 0.367 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.344182e-01 0.362 0 0
RNA Polymerase I Transcription R-HSA-73864 4.376228e-01 0.359 0 0
Chromosome Maintenance R-HSA-73886 4.379290e-01 0.359 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.401947e-01 0.356 0 0
Signaling by WNT in cancer R-HSA-4791275 4.402792e-01 0.356 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.402792e-01 0.356 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.402792e-01 0.356 0 0
Disease R-HSA-1643685 4.414049e-01 0.355 0 0
SLC transporter disorders R-HSA-5619102 4.420139e-01 0.355 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.456264e-01 0.351 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.456264e-01 0.351 0 0
ERKs are inactivated R-HSA-202670 4.456264e-01 0.351 0 0
Signaling by AXIN mutants R-HSA-4839735 4.456264e-01 0.351 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.456264e-01 0.351 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.456264e-01 0.351 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.456264e-01 0.351 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 4.456264e-01 0.351 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.456264e-01 0.351 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.503841e-01 0.346 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.516268e-01 0.345 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.516268e-01 0.345 0 0
Nuclear RNA decay R-HSA-9930044 4.533946e-01 0.344 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.533946e-01 0.344 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.533946e-01 0.344 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.533946e-01 0.344 0 0
Cardiogenesis R-HSA-9733709 4.533946e-01 0.344 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.548179e-01 0.342 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.548179e-01 0.342 0 0
Signaling by MET R-HSA-6806834 4.548179e-01 0.342 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.604971e-01 0.337 0 0
Signaling by FGFR1 R-HSA-5654736 4.604971e-01 0.337 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.604971e-01 0.337 0 0
Ion homeostasis R-HSA-5578775 4.604971e-01 0.337 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.633505e-01 0.334 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.633505e-01 0.334 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.663325e-01 0.331 0 0
Vpu mediated degradation of CD4 R-HSA-180534 4.663325e-01 0.331 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.663325e-01 0.331 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.670160e-01 0.331 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.670160e-01 0.331 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.670160e-01 0.331 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.670160e-01 0.331 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.670160e-01 0.331 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.670160e-01 0.331 0 0
Repression of WNT target genes R-HSA-4641265 4.670160e-01 0.331 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.670160e-01 0.331 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.670160e-01 0.331 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.670160e-01 0.331 0 0
Conjugation of salicylate with glycine R-HSA-177128 4.670160e-01 0.331 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.670160e-01 0.331 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.670160e-01 0.331 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.670160e-01 0.331 0 0
OAS antiviral response R-HSA-8983711 4.670160e-01 0.331 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.769917e-01 0.321 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.778950e-01 0.321 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.790869e-01 0.320 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.790869e-01 0.320 0 0
eNOS activation R-HSA-203615 4.790869e-01 0.320 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 4.790869e-01 0.320 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.790869e-01 0.320 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.790869e-01 0.320 0 0
Signal amplification R-HSA-392518 4.790869e-01 0.320 0 0
Dual incision in TC-NER R-HSA-6782135 4.804764e-01 0.318 0 0
Adenylate cyclase activating pathway R-HSA-170660 4.875815e-01 0.312 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.875815e-01 0.312 0 0
FGFR1c ligand binding and activation R-HSA-190373 4.875815e-01 0.312 0 0
Frs2-mediated activation R-HSA-170968 4.875815e-01 0.312 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.875815e-01 0.312 0 0
Maturation of nucleoprotein R-HSA-9683610 4.875815e-01 0.312 0 0
Interleukin-6 signaling R-HSA-1059683 4.875815e-01 0.312 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.886524e-01 0.311 0 0
Extension of Telomeres R-HSA-180786 4.903346e-01 0.310 0 0
Regulation of beta-cell development R-HSA-186712 4.903346e-01 0.310 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.916528e-01 0.308 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.916528e-01 0.308 0 0
Co-inhibition by PD-1 R-HSA-389948 4.923695e-01 0.308 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.923695e-01 0.308 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.969784e-01 0.304 0 0
tRNA Aminoacylation R-HSA-379724 5.001002e-01 0.301 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.031491e-01 0.298 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.040257e-01 0.298 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.040257e-01 0.298 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.040257e-01 0.298 0 0
RUNX2 regulates bone development R-HSA-8941326 5.040257e-01 0.298 0 0
FGFR2 mutant receptor activation R-HSA-1839126 5.040257e-01 0.298 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.052461e-01 0.296 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.073547e-01 0.295 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.073547e-01 0.295 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.073547e-01 0.295 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.073547e-01 0.295 0 0
Hydrolysis of LPC R-HSA-1483115 5.073547e-01 0.295 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.073547e-01 0.295 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.073547e-01 0.295 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.073547e-01 0.295 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.073547e-01 0.295 0 0
Acyl chain remodeling of CL R-HSA-1482798 5.073547e-01 0.295 0 0
DNA Replication R-HSA-69306 5.086828e-01 0.294 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.090503e-01 0.293 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.097699e-01 0.293 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.097699e-01 0.293 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.134531e-01 0.289 0 0
Death Receptor Signaling R-HSA-73887 5.147682e-01 0.288 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 5.162018e-01 0.287 0 0
Degradation of AXIN R-HSA-4641257 5.162018e-01 0.287 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.162018e-01 0.287 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.162018e-01 0.287 0 0
Adipogenesis R-HSA-9843745 5.187108e-01 0.285 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.193404e-01 0.285 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.193404e-01 0.285 0 0
Heme signaling R-HSA-9707616 5.193404e-01 0.285 0 0
Erythropoietin activates RAS R-HSA-9027284 5.263660e-01 0.279 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.263660e-01 0.279 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 5.263660e-01 0.279 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.263660e-01 0.279 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.263660e-01 0.279 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.263660e-01 0.279 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 5.263660e-01 0.279 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.263660e-01 0.279 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.263660e-01 0.279 0 0
p75NTR signals via NF-kB R-HSA-193639 5.263660e-01 0.279 0 0
MET promotes cell motility R-HSA-8875878 5.281780e-01 0.277 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.281780e-01 0.277 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.281780e-01 0.277 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.288089e-01 0.277 0 0
Diseases of programmed cell death R-HSA-9645723 5.296756e-01 0.276 0 0
HCMV Late Events R-HSA-9610379 5.328594e-01 0.273 0 0
IGF1R signaling cascade R-HSA-2428924 5.381726e-01 0.269 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.399514e-01 0.268 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 5.399514e-01 0.268 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.446448e-01 0.264 0 0
Killing mechanisms R-HSA-9664420 5.446448e-01 0.264 0 0
Negative regulation of FLT3 R-HSA-9706369 5.446448e-01 0.264 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.446448e-01 0.264 0 0
Prolonged ERK activation events R-HSA-169893 5.446448e-01 0.264 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.446448e-01 0.264 0 0
Differentiation of T cells R-HSA-9945266 5.446448e-01 0.264 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.446448e-01 0.264 0 0
Downstream TCR signaling R-HSA-202424 5.456290e-01 0.263 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.474290e-01 0.262 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.515200e-01 0.258 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.515200e-01 0.258 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.515200e-01 0.258 0 0
Diseases of Immune System R-HSA-5260271 5.515200e-01 0.258 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.515200e-01 0.258 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.518827e-01 0.258 0 0
Integration of energy metabolism R-HSA-163685 5.573980e-01 0.254 1 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 5.588452e-01 0.253 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.622193e-01 0.250 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.622193e-01 0.250 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.622193e-01 0.250 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.622193e-01 0.250 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.622193e-01 0.250 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.622193e-01 0.250 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.622193e-01 0.250 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.628819e-01 0.250 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.628819e-01 0.250 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.628819e-01 0.250 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.740359e-01 0.241 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.740359e-01 0.241 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.740359e-01 0.241 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.740359e-01 0.241 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 5.740359e-01 0.241 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.791165e-01 0.237 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 5.791165e-01 0.237 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.791165e-01 0.237 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.791165e-01 0.237 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.791165e-01 0.237 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.849812e-01 0.233 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.849812e-01 0.233 0 0
Mitochondrial biogenesis R-HSA-1592230 5.861406e-01 0.232 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.920299e-01 0.228 0 0
Homology Directed Repair R-HSA-5693538 5.928199e-01 0.227 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.953624e-01 0.225 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.953624e-01 0.225 0 0
PKA activation in glucagon signalling R-HSA-164378 5.953624e-01 0.225 0 0
FGFR1 ligand binding and activation R-HSA-190242 5.953624e-01 0.225 0 0
PKA activation R-HSA-163615 5.953624e-01 0.225 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 5.953624e-01 0.225 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.953624e-01 0.225 0 0
Mismatch Repair R-HSA-5358508 5.953624e-01 0.225 0 0
Defective pyroptosis R-HSA-9710421 5.957172e-01 0.225 0 0
TBC/RABGAPs R-HSA-8854214 5.957172e-01 0.225 0 0
Signaling by FGFR4 R-HSA-5654743 5.957172e-01 0.225 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 5.957172e-01 0.225 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.038269e-01 0.219 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.064705e-01 0.217 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.064705e-01 0.217 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.090548e-01 0.215 0 0
Regulation of signaling by CBL R-HSA-912631 6.109823e-01 0.214 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.109823e-01 0.214 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.109823e-01 0.214 0 0
Pyrimidine biosynthesis R-HSA-500753 6.109823e-01 0.214 0 0
Specification of the neural plate border R-HSA-9834899 6.109823e-01 0.214 0 0
Amino Acid conjugation R-HSA-156587 6.109823e-01 0.214 0 0
Conjugation of carboxylic acids R-HSA-159424 6.109823e-01 0.214 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 6.109823e-01 0.214 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.109823e-01 0.214 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.109823e-01 0.214 0 0
Rap1 signalling R-HSA-392517 6.109823e-01 0.214 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.109823e-01 0.214 0 0
Maturation of nucleoprotein R-HSA-9694631 6.109823e-01 0.214 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.165611e-01 0.210 0 0
Nucleosome assembly R-HSA-774815 6.165611e-01 0.210 0 0
Signaling by FGFR3 R-HSA-5654741 6.165611e-01 0.210 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 6.165611e-01 0.210 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.165611e-01 0.210 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.187658e-01 0.208 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.260001e-01 0.203 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.260001e-01 0.203 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.260001e-01 0.203 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.260001e-01 0.203 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.260001e-01 0.203 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.260001e-01 0.203 0 0
Signaling by NODAL R-HSA-1181150 6.260001e-01 0.203 0 0
Acyl chain remodelling of PI R-HSA-1482922 6.260001e-01 0.203 0 0
Creatine metabolism R-HSA-71288 6.260001e-01 0.203 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.260001e-01 0.203 0 0
Protein hydroxylation R-HSA-9629569 6.260001e-01 0.203 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.260001e-01 0.203 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.266696e-01 0.203 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.266696e-01 0.203 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.266696e-01 0.203 0 0
Regulation of pyruvate metabolism R-HSA-9861718 6.266696e-01 0.203 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.266696e-01 0.203 0 0
DNA Repair R-HSA-73894 6.330262e-01 0.199 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 6.365700e-01 0.196 0 0
Parasitic Infection Pathways R-HSA-9824443 6.367952e-01 0.196 0 0
Leishmania infection R-HSA-9658195 6.367952e-01 0.196 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.404390e-01 0.194 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.404390e-01 0.194 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.404390e-01 0.194 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.404390e-01 0.194 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.404390e-01 0.194 0 0
Acyl chain remodelling of PG R-HSA-1482925 6.404390e-01 0.194 0 0
Basigin interactions R-HSA-210991 6.404390e-01 0.194 0 0
Lagging Strand Synthesis R-HSA-69186 6.404390e-01 0.194 0 0
Gastrulation R-HSA-9758941 6.414592e-01 0.193 0 0
Interleukin-1 signaling R-HSA-9020702 6.418680e-01 0.193 0 0
GPER1 signaling R-HSA-9634597 6.462634e-01 0.190 0 0
NGF-stimulated transcription R-HSA-9031628 6.462634e-01 0.190 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.543214e-01 0.184 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.543214e-01 0.184 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.543214e-01 0.184 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.543214e-01 0.184 0 0
Assembly Of The HIV Virion R-HSA-175474 6.543214e-01 0.184 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 6.581790e-01 0.182 0 0
PI3K Cascade R-HSA-109704 6.650341e-01 0.177 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.650341e-01 0.177 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.650341e-01 0.177 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.676686e-01 0.175 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.676686e-01 0.175 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.676686e-01 0.175 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.676686e-01 0.175 0 0
Signaling by KIT in disease R-HSA-9669938 6.676686e-01 0.175 0 0
LDL clearance R-HSA-8964038 6.676686e-01 0.175 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.686409e-01 0.175 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.686409e-01 0.175 0 0
RSV-host interactions R-HSA-9833110 6.686409e-01 0.175 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.690533e-01 0.175 0 0
Meiotic recombination R-HSA-912446 6.741145e-01 0.171 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.741145e-01 0.171 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.741145e-01 0.171 0 0
The phototransduction cascade R-HSA-2514856 6.741145e-01 0.171 0 0
Carnitine shuttle R-HSA-200425 6.805012e-01 0.167 0 0
Growth hormone receptor signaling R-HSA-982772 6.805012e-01 0.167 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.829940e-01 0.166 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.868809e-01 0.163 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.916744e-01 0.160 0 0
Nucleotide biosynthesis R-HSA-8956320 6.916744e-01 0.160 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 6.928390e-01 0.159 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.928390e-01 0.159 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.928390e-01 0.159 0 0
Mitochondrial RNA degradation R-HSA-9836573 6.928390e-01 0.159 0 0
Interleukin-6 family signaling R-HSA-6783589 6.928390e-01 0.159 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.939878e-01 0.159 0 0
Adaptive Immune System R-HSA-1280218 7.032893e-01 0.153 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.047011e-01 0.152 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.047011e-01 0.152 0 0
Formation of the nephric duct R-HSA-9830364 7.047011e-01 0.152 0 0
Laminin interactions R-HSA-3000157 7.047011e-01 0.152 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.161058e-01 0.145 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.161058e-01 0.145 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.161058e-01 0.145 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.161058e-01 0.145 0 0
NRAGE signals death through JNK R-HSA-193648 7.165438e-01 0.145 0 0
TNF signaling R-HSA-75893 7.165438e-01 0.145 0 0
Toll-like Receptor Cascades R-HSA-168898 7.184589e-01 0.144 0 0
IRS-mediated signalling R-HSA-112399 7.244508e-01 0.140 0 0
Packaging Of Telomere Ends R-HSA-171306 7.270708e-01 0.138 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.270708e-01 0.138 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.270708e-01 0.138 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.270708e-01 0.138 0 0
Insulin processing R-HSA-264876 7.270708e-01 0.138 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.270708e-01 0.138 0 0
Pyruvate metabolism R-HSA-70268 7.276970e-01 0.138 0 0
Pyroptosis R-HSA-5620971 7.376128e-01 0.132 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.397059e-01 0.131 0 0
Metabolism of polyamines R-HSA-351202 7.470594e-01 0.127 0 0
Signaling by Erythropoietin R-HSA-9006335 7.477483e-01 0.126 0 0
DNA methylation R-HSA-5334118 7.477483e-01 0.126 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.477483e-01 0.126 0 0
DARPP-32 events R-HSA-180024 7.477483e-01 0.126 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.542338e-01 0.122 0 0
DAP12 signaling R-HSA-2424491 7.574929e-01 0.121 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.574929e-01 0.121 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.574929e-01 0.121 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.574929e-01 0.121 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.668616e-01 0.115 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.668616e-01 0.115 0 0
Downstream signal transduction R-HSA-186763 7.668616e-01 0.115 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.680572e-01 0.115 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 7.696999e-01 0.114 0 0
Insulin receptor signalling cascade R-HSA-74751 7.747119e-01 0.111 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.747119e-01 0.111 0 0
Ion transport by P-type ATPases R-HSA-936837 7.747119e-01 0.111 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.754823e-01 0.110 0 0
Collagen formation R-HSA-1474290 7.754823e-01 0.110 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.758689e-01 0.110 0 0
G0 and Early G1 R-HSA-1538133 7.758689e-01 0.110 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.758689e-01 0.110 0 0
Cellular response to hypoxia R-HSA-1234174 7.811992e-01 0.107 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.845288e-01 0.105 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 7.845288e-01 0.105 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.845288e-01 0.105 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 7.875222e-01 0.104 0 0
Formation of the cornified envelope R-HSA-6809371 7.908434e-01 0.102 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.928545e-01 0.101 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.928545e-01 0.101 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.928545e-01 0.101 0 0
Acyl chain remodelling of PC R-HSA-1482788 7.928545e-01 0.101 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.928545e-01 0.101 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.928545e-01 0.101 0 0
Regulated Necrosis R-HSA-5218859 7.996871e-01 0.097 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.008591e-01 0.096 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.008591e-01 0.096 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.008591e-01 0.096 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.008591e-01 0.096 0 0
Signaling by NOTCH2 R-HSA-1980145 8.008591e-01 0.096 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.008591e-01 0.096 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.008591e-01 0.096 0 0
Mitophagy R-HSA-5205647 8.008591e-01 0.096 0 0
Regulation of insulin secretion R-HSA-422356 8.017023e-01 0.096 0 0
HATs acetylate histones R-HSA-3214847 8.066269e-01 0.093 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.085548e-01 0.092 0 0
Oncogene Induced Senescence R-HSA-2559585 8.085548e-01 0.092 0 0
Glycosphingolipid catabolism R-HSA-9840310 8.112307e-01 0.091 0 0
ABC-family proteins mediated transport R-HSA-382556 8.114481e-01 0.091 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.159535e-01 0.088 0 0
Metabolism of cofactors R-HSA-8978934 8.167771e-01 0.088 0 0
Hedgehog 'on' state R-HSA-5632684 8.167771e-01 0.088 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.230668e-01 0.085 0 0
Cleavage of the damaged purine R-HSA-110331 8.230668e-01 0.085 0 0
Interferon gamma signaling R-HSA-877300 8.246371e-01 0.084 0 0
Ca2+ pathway R-HSA-4086398 8.274343e-01 0.082 0 0
Depurination R-HSA-73927 8.299055e-01 0.081 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.299055e-01 0.081 0 0
Elastic fibre formation R-HSA-1566948 8.299055e-01 0.081 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.299055e-01 0.081 0 0
Neddylation R-HSA-8951664 8.350386e-01 0.078 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.364804e-01 0.078 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.364804e-01 0.078 0 0
Signaling by ALK R-HSA-201556 8.364804e-01 0.078 0 0
RAS processing R-HSA-9648002 8.364804e-01 0.078 0 0
Signaling by NOTCH1 R-HSA-1980143 8.423756e-01 0.074 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.428014e-01 0.074 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.428014e-01 0.074 0 0
Deubiquitination R-HSA-5688426 8.463788e-01 0.072 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.488785e-01 0.071 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.488785e-01 0.071 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.488785e-01 0.071 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.488785e-01 0.071 0 0
Stimuli-sensing channels R-HSA-2672351 8.504215e-01 0.070 0 0
Integrin cell surface interactions R-HSA-216083 8.516748e-01 0.070 0 0
SLC-mediated transport of organic anions R-HSA-9955298 8.516748e-01 0.070 0 0
ABC transporter disorders R-HSA-5619084 8.516748e-01 0.070 0 0
Intra-Golgi traffic R-HSA-6811438 8.547210e-01 0.068 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.547210e-01 0.068 0 0
Translation of Structural Proteins R-HSA-9683701 8.547210e-01 0.068 0 0
GPCR downstream signalling R-HSA-388396 8.553709e-01 0.068 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.561346e-01 0.067 0 0
Activation of GABAB receptors R-HSA-991365 8.603380e-01 0.065 0 0
GABA B receptor activation R-HSA-977444 8.603380e-01 0.065 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.603380e-01 0.065 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.603380e-01 0.065 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.603380e-01 0.065 0 0
Depyrimidination R-HSA-73928 8.603380e-01 0.065 0 0
Sphingolipid metabolism R-HSA-428157 8.629775e-01 0.064 0 0
Amyloid fiber formation R-HSA-977225 8.646889e-01 0.063 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.653668e-01 0.063 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.684411e-01 0.061 0 0
DAP12 interactions R-HSA-2172127 8.709298e-01 0.060 0 0
Amine ligand-binding receptors R-HSA-375280 8.709298e-01 0.060 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 8.709298e-01 0.060 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.727746e-01 0.059 0 0
Ub-specific processing proteases R-HSA-5689880 8.728704e-01 0.059 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.759210e-01 0.058 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.759210e-01 0.058 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.807195e-01 0.055 0 0
Diseases of DNA repair R-HSA-9675135 8.807195e-01 0.055 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.807195e-01 0.055 0 0
Synthesis of PC R-HSA-1483191 8.853327e-01 0.053 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.853327e-01 0.053 0 0
Plasma lipoprotein remodeling R-HSA-8963899 8.897677e-01 0.051 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.940315e-01 0.049 0 0
Chemokine receptors bind chemokines R-HSA-380108 8.940315e-01 0.049 0 0
Azathioprine ADME R-HSA-9748787 8.981306e-01 0.047 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 8.998890e-01 0.046 0 0
Neurotransmitter release cycle R-HSA-112310 9.008589e-01 0.045 0 0
Base Excision Repair R-HSA-73884 9.008589e-01 0.045 0 0
Interleukin-1 family signaling R-HSA-446652 9.013268e-01 0.045 0 0
Complex IV assembly R-HSA-9864848 9.020714e-01 0.045 0 0
Protein localization R-HSA-9609507 9.037429e-01 0.044 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.039322e-01 0.044 0 0
PPARA activates gene expression R-HSA-1989781 9.084187e-01 0.042 0 0
Signaling by Insulin receptor R-HSA-74752 9.098137e-01 0.041 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.098137e-01 0.041 0 0
Metabolism of proteins R-HSA-392499 9.108413e-01 0.041 0 0
Ion channel transport R-HSA-983712 9.114448e-01 0.040 0 0
G alpha (i) signalling events R-HSA-418594 9.118354e-01 0.040 0 0
FCGR activation R-HSA-2029481 9.126265e-01 0.040 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.127691e-01 0.040 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.127691e-01 0.040 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.127691e-01 0.040 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.128919e-01 0.040 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.130037e-01 0.040 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.151572e-01 0.039 0 0
Mitochondrial protein degradation R-HSA-9837999 9.153569e-01 0.038 0 0
Synthesis of PA R-HSA-1483166 9.227173e-01 0.035 0 0
Signaling by GPCR R-HSA-372790 9.239867e-01 0.034 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.257082e-01 0.034 0 0
Cardiac conduction R-HSA-5576891 9.282772e-01 0.032 0 0
Peroxisomal protein import R-HSA-9033241 9.285836e-01 0.032 0 0
Sialic acid metabolism R-HSA-4085001 9.285836e-01 0.032 0 0
G alpha (q) signalling events R-HSA-416476 9.296129e-01 0.032 0 0
GABA receptor activation R-HSA-977443 9.313478e-01 0.031 0 0
RAB geranylgeranylation R-HSA-8873719 9.313478e-01 0.031 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.313478e-01 0.031 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.313478e-01 0.031 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.313478e-01 0.031 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.313478e-01 0.031 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.313478e-01 0.031 0 0
Aquaporin-mediated transport R-HSA-445717 9.340052e-01 0.030 0 0
Mitochondrial protein import R-HSA-1268020 9.365599e-01 0.028 0 0
Signaling by PDGF R-HSA-186797 9.365599e-01 0.028 0 0
G alpha (s) signalling events R-HSA-418555 9.406744e-01 0.027 0 0
Platelet homeostasis R-HSA-418346 9.460619e-01 0.024 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 9.479263e-01 0.023 0 0
Kidney development R-HSA-9830369 9.479263e-01 0.023 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.499429e-01 0.022 0 0
Respiratory electron transport R-HSA-611105 9.506485e-01 0.022 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.533430e-01 0.021 0 0
ECM proteoglycans R-HSA-3000178 9.555366e-01 0.020 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.560339e-01 0.020 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.571094e-01 0.019 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.572589e-01 0.019 0 0
Aspirin ADME R-HSA-9749641 9.589145e-01 0.018 0 0
Bacterial Infection Pathways R-HSA-9824439 9.617308e-01 0.017 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.620362e-01 0.017 0 0
Iron uptake and transport R-HSA-917937 9.620362e-01 0.017 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.624133e-01 0.017 0 0
Peptide hormone metabolism R-HSA-2980736 9.648235e-01 0.016 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.649210e-01 0.016 0 0
Translation of Structural Proteins R-HSA-9694635 9.649210e-01 0.016 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.691233e-01 0.014 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.711951e-01 0.013 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.749873e-01 0.011 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.763752e-01 0.010 0 0
Keratinization R-HSA-6805567 9.776303e-01 0.010 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.788379e-01 0.009 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.798318e-01 0.009 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.802350e-01 0.009 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.809630e-01 0.008 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.809630e-01 0.008 0 0
Post-translational protein modification R-HSA-597592 9.812674e-01 0.008 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.820886e-01 0.008 0 0
Potassium Channels R-HSA-1296071 9.853035e-01 0.006 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.880506e-01 0.005 0 0
Visual phototransduction R-HSA-2187338 9.888637e-01 0.005 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.895004e-01 0.005 0 0
Arachidonate metabolism R-HSA-2142753 9.906271e-01 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.938502e-01 0.003 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.969876e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.971048e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.972470e-01 0.001 0 0
Metabolism of nucleotides R-HSA-15869 9.975068e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.975872e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.984154e-01 0.001 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.986912e-01 0.001 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.990090e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.991536e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.993341e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.993842e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.994312e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.997471e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999234e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999378e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999651e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999828e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999934e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999962e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999993e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999995e-01 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways