MAPKAPK5

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A4FU28	S140	Sugiyama	CTAGE9	AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0	S939	Sugiyama	POTEF A26C1B	VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A5A3E0	Y940	Sugiyama	POTEF A26C1B	ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00115	S70	Sugiyama	DNASE2 DNASE2A DNL2	QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00165	S192	Sugiyama	HAX1 HS1BP1	VWPMDPHPRtREDNDLDsQVsQEGLGPVLQPQPKSYFKsIS
O00273	S28	Sugiyama	DFFA DFF1 DFF45 H13	GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O00299	S211	Sugiyama	CLIC1 G6 NCC27	CKKYRGFTIPEAFRGVHRYLsNAyAREEFAstCPDDEEIEL
O00299	S221	Sugiyama	CLIC1 G6 NCC27	EAFRGVHRYLsNAyAREEFAstCPDDEEIELAyEQVAKALK
O00418	S377	GPS6\|SIGNOR\|iPTMNet\|EPSD	EEF2K	CGsPQVRTLsGSRPPLLRPLsENSGDENMSDVTFDsLPSsP
O00488	S93	Sugiyama	ZNF593 ZT86	STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O14497	S363	Sugiyama	ARID1A BAF250 BAF250A C1orf4 OSA1 SMARCF1	AAAAAAASGGAQQRsHHAPMsPGssGGGGQPLARtPQPssP
O14545	S409	Sugiyama	TRAFD1 FLN29	CDQRPATATNHVTEGIPRLDsQPQEtsPELPRRRVRHQGDL
O14545	T323	Sugiyama	TRAFD1 FLN29	ELLIDHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQ
O14672	S630	Sugiyama	ADAM10 KUZ MADM	TGSVQWSRHFSGRTITLQPGsPCNDFRGYCDVFMRCRLVDA
O14745	S280	Sugiyama	NHERF1 NHERF SLC9A3R1	tNGEIQKENsREALAEAALEsPRPALVRsAssDtsEELNsQ
O14745	S290	Sugiyama	NHERF1 NHERF SLC9A3R1	REALAEAALEsPRPALVRsAssDtsEELNsQDsPPKQDSTA
O14910	S130	Sugiyama	LIN7A MALS1 VELI1	ELPKTDEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLK
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14980	S1055	Sugiyama	XPO1 CRM1	LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15226	S618	Sugiyama	NKRF ITBA4 NRF	VNKIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQ
O15226	T620	Sugiyama	NKRF ITBA4 NRF	KIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQIA
O15460	S531	Sugiyama	P4HA2 UNQ290/PRO330	KWVSNKWFHERGQEFLRPCGstEVD________________
O43164	S253	Sugiyama	PJA2 KIAA0438 RNF131	LDsVPLVKssAGDTEFVHQNsQEIQRSSQDEMVSTKQQNNT
O43390	S426	Sugiyama	HNRNPR HNRPR	IVLAKPPDKKRKERQAARQAsRstAyEDyyyHPPPRMPPPI
O43524	S215	GPS6\|EPSD	FOXO3 FKHRL1 FOXO3A	KDKGDSNSSAGWKNsIRHNLsLHSRFMRVQNEGTGKssWWI
O43524	S253	GPS6\|EPSD	FOXO3 FKHRL1 FOXO3A	WWIINPDGGKsGKAPRRRAVsMDNsNKYTKSRGRAAKKKAA
O43524	S551	GPS6\|EPSD	FOXO3 FKHRL1 FOXO3A	QNLLHHQHQTQGALGGSRALsNsVsNMGLSESSSLGSAKHQ
O43524	S555	GPS6	FOXO3 FKHRL1 FOXO3A	HHQHQTQGALGGSRALsNsVsNMGLSESSSLGSAKHQQQsP
O43615	S180	Sugiyama	TIMM44 MIMT44 TIM44	AESVSKGGEKLGRTAAFRALsQGVEsVKKEIDDsVLGQtGP
O43707	S763	Sugiyama	ACTN4	IARTINEVENQILtRDAKGIsQEQMQEFRASFNHFDKDHGG
O43823	S323	Sugiyama	AKAP8 AKAP95	RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852	T65	Sugiyama	CALU	FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60220	S94	Sugiyama	TIMM8A DDP DDP1 TIM8A	SQFILNRLEQTQKSKPVFSEsLsD_________________
O60229	S487	SIGNOR\|EPSD\|PSP	KALRN DUET DUO HAPIP TRAD	AYTEVSQDGKALLDVLQRPLsPGNSESLTATANYSKAVHQV
O60664	S148	Sugiyama	PLIN3 M6PRBP1 TIP47	KVsGAQEMVssAKDTVAtQLsEAVDATRGAVQSGVDKTKsV
O60749	S365	Sugiyama	SNX2 TRG9	AKSAAMLGNsEDHTALSRALsQLAEVEEKIDQLHQEQAFAD
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75179	S2045	Sugiyama	ANKRD17 GTAR KIAA0697	TNATYPMPTAKEHyPVssPssPsPPAQPGGVsRNsPLDCGs
O75369	S1505	Sugiyama	FLNB FLN1L FLN3 TABP TAP	PSQEGPYMVSVKYADEEIPRsPFKVKVLPTYDASKVtAsGP
O75376	S158	Sugiyama	NCOR1 KIAA1047	RASADAKKDPAFGGKHEAPssPIsGQPCGDDQNAsPsKLSK
O75436	T102	Sugiyama	VPS26A VPS26	KSNTHEFVNLVKELALPGELtQSRSYDFEFMQVEKPYESYI
O75534	S584	Sugiyama	CSDE1 D1S155E KIAA0885 NRU UNR	YSLSKGKGNKVSAEKVNKtHsVNGItEEADPTIysGKVIRP
O75569	S18	Sugiyama	PRKRA PACT RAX HSD-14 HSD14	___MSQSRHRAEAPPLEREDsGtFsLGKMITAKPGKTPIQV
O94888	S280	Sugiyama	UBXN7 KIAA0794 UBXD7	EHGQLDGLsssPPKKCARsEsLIDAsEDsQLEAAIRASLQE
O94992	S268	Sugiyama	HEXIM1 CLP1 EDG1 HIS1 MAQ1	EDGGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELI
O94992	T270	Sugiyama	HEXIM1 CLP1 EDG1 HIS1 MAQ1	GGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELIKE
O95155	S105	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95155	T27	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	DEIRRRRLARLAGGQtsQPttPLtsPQRENPPGPPIAASAP
O95155	T30	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	RRRRLARLAGGQtsQPttPLtsPQRENPPGPPIAASAPGPs
O95239	S1038	Sugiyama	KIF4A KIF4	FEYVPPKPKPSRVKEKFLEQsMDIEDLKYCSEHSVNEHEDG
O95359	S2321	Sugiyama	TACC2	RPKMKKtPEKLDNtPAsPPRsPAEPNDIPIAKGTYTFDIDK
O95453	S557	Sugiyama	PARN DAN	KRLNPQCIPYTLQNHYYRNNsFtAPstVGKRNLsPsQEEAG
O95625	S511	Sugiyama	ZBTB11	TAKTDFGPDDDTYRSRLRQRsVNEGAYIRLHKGMEKKLQKR
O95816	S73	Sugiyama	BAG2	KEILLEMIHSIQNSQDMRQIsDGEREELNLTANRLMGRTLT
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00966	T219	Sugiyama	ASS1 ASS	KNQAPPGLytKtQDPAKAPNtPDILEIEFKKGVPVKVTNVK
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083	S173	Sugiyama	ANXA1 ANX1 LPC1	NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04083	S189	Sugiyama	ANXA1 ANX1 LPC1	tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	S312	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA
P04406	S321	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE______
P04637	S37	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TP53 P53	EtFsDLWKLLPENNVLsPLPsQAMDDLMLsPDDIEQWFtED
P04792	S15	Sugiyama	HSPB1 HSP27 HSP28	______MTERRVPFsLLRGPsWDPFRDWyPHsRLFDQAFGL
P04792	S78	GPS6\|EPSD\|Sugiyama	HSPB1 HSP27 HSP28	LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792	S82	GPS6\|Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05198	S219	Sugiyama	EIF2S1 EIF2A	CYGYEGIDAVKEALRAGLNCsTENMPIKINLIAPPRYVMTT
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05455	S94	Sugiyama	SSB	KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05783	S177	Sugiyama	KRT18 CYK18 PIG46	ARLAADDFRVKyETELAMRQsVENDIHGLRKVIDDTNItRL
P06733	S27	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733	S291	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	IsPDQLADLyKsFIKDyPVVsIEDPFDQDDWGAWQKFtAsA
P06744	S455	Sugiyama	GPI	ALMRGKSTEEARKELQAAGKsPEDLERLLPHKVFEGNRPTN
P06744	T109	Sugiyama	GPI	KINyTEGRAVLHVALRNRsNtPILVDGKDVMPEVNKVLDKM
P07101	S19	SIGNOR\|PSP	TH TYH	__MPTPDATTPQAKGFRRAVsELDAKQAEAIMVRGQGAPGP
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	S44	Sugiyama	LDHB	ITVVGVGQVGMACAISILGKsLADELALVDVLEDKLKGEMM
P07237	S427	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07339	S37	Sugiyama	CTSD CPSD	PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07814	S1511	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	PGAKCVCGKNPAKyytLFGRsy___________________
P07814	S335	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07814	S886	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	EKTGKEyIPGQPPLsQssDssPtRNsEPAGLEtPEAKVLFD
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S50	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P08195	S598	Sugiyama	SLC3A2 MDU1	LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195	S607	Sugiyama	SLC3A2 MDU1	ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238	S45	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238	S460	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S535	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	EPIDEyCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEE
P08670	S325	Sugiyama	VIM	NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P09382	S63	Sugiyama	LGALS1	CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0C0L4	S1294	Sugiyama	C4A CO4 CPAMD2	LHEGKAEMADQASAWLTRQGsFQGGFRSTQDTVIALDALSA
P0C0L5	S1294	Sugiyama	C4B CO4 CPAMD3; C4B_2	LHEGKAEMADQAAAWLTRQGsFQGGFRSTQDTVIALDALSA
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG41	S140	Sugiyama	CTAGE8	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P10809	S453	Sugiyama	HSPD1 HSP60	EEGIVLGGGCALLRCIPALDsLtPANEDQKIGIEIIKRTLK
P10809	S70	Sugiyama	HSPD1 HSP60	AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142	S362	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	RIPKIQKLLQDFFNGKELNKsINPDEAVAyGAAVQAAILsG
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11532	S3623	Sugiyama	DMD	EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P11586	S872	Sugiyama	MTHFD1 MTHFC MTHFD	YTKQGFGNLPICMAKtHLsLsHNPEQKGVPTGFILPIRDIR
P12270	S2155	Sugiyama	TPR	PstPtLVVPHRtDGFAEAIHsPQVAGVPRFRFGPPEDMPQT
P12956	S477	Sugiyama	XRCC6 G22P1	EQVGKMKAIVEKLRFtYRsDsFENPVLQQHFRNLEALALDL
P13489	S178	Sugiyama	RNH1 PRI RNH	SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639	S38	Sugiyama	EEF2 EF2	NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639	S584	Sugiyama	EEF2 EF2	DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13639	S593	Sugiyama	EEF2 EF2	SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314	S478	Sugiyama	PRKCSH G19P1	DKFSAMKyEQGtGCWQGPNRstTVRLLCGKEtMVtStTEPS
P14618	S37	Sugiyama	PKM OIP3 PK2 PK3 PKM2	QLHAAMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRs
P14618	S77	Sugiyama	PKM OIP3 PK2 PK3 PKM2	sVEtLKEMIKsGMNVARLNFsHGtHEyHAEtIKNVRtAtEs
P14625	S106	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625	S447	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	PKyLNFVKGVVDsDDLPLNVsREtLQQHKLLKVIRKKLVRK
P14625	S514	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625	S515	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14625	S64	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625	S674	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	WsGNMERIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLI
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311	S536	Sugiyama	EZR VIL2	KRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNE
P15311	S539	Sugiyama	EZR VIL2	TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15336	T69	Sugiyama	ATF2 CREB2 CREBP1	HEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELA
P15336	T71	Sugiyama	ATF2 CREB2 CREBP1	MtLKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELAsP
P15336	T73	Sugiyama	ATF2 CREB2 CREBP1	LKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELAsPFE
P15374	S128	Sugiyama	UCHL3	KDKMHFESGSTLKKFLEEsVsMsPEERARyLENyDAIRVtH
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17544	T51	Sugiyama	ATF7 ATFA	HEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEVGLFNELA
P17544	T53	Sugiyama	ATF7 ATFA	MTLKFGPARtDsVIIADQtPtPtRFLKNCEEVGLFNELASS
P17812	S573	Sugiyama	CTPS1 CTPS	HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P17812	S575	Sugiyama	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P17987	S544	Sugiyama	TCP1 CCT1 CCTA	ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P18615	S115	Sugiyama	NELFE RD RDBP	KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P18669	S152	Sugiyama	PGAM1 PGAMA CDABP0006	FysNIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIV
P18669	S31	Sugiyama	PGAM1 PGAMA CDABP0006	HGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALRDAGyE
P18754	S85	Sugiyama	RCC1 CHC1	IPEDVVQAEAGGMHTVCLSKsGQVysFGCNDEGALGRDtsV
P19338	S328	Sugiyama	NCL	NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338	S458	Sugiyama	NCL	TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338	S580	Sugiyama	NCL	PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P19338	S591	Sugiyama	NCL	SKTLFVKGLsEDttEEtLKEsFDGsVRARIVTDRETGssKG
P19338	S619	Sugiyama	NCL	RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P20618	S151	Sugiyama	PSMB1 PSC5	PYYVYNIIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASA
P22059	S240	Sugiyama	OSBP OSBP1	DLSTCNDLIAKHGTALQRsLsELEsLKLPAESNEKIKQVNE
P22626	S212	Sugiyama	HNRNPA2B1 HNRPA2B1	EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23381	S467	Sugiyama	WARS1 IFI53 WARS WRS	ARRKEVTDEIVKEFMTPRKLsFDFQ________________
P23396	T221	Sugiyama	RPS3 OK/SW-cl.26	KKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPVP
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588	S597	Sugiyama	EIF4B	KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______
P24666	S119	Sugiyama	ACP1	DLNRKSNQVKTCKAKIELLGsYDPQKQLIIEDPyyGNDsDF
P24928	S1913	Sugiyama	POLR2A POLR2	PtysPtsPVytPtsPKysPtsPtysPtsPKysPtsPtysPt
P24928	S1920	Sugiyama	POLR2A POLR2	PVytPtsPKysPtsPtysPtsPKysPtsPtysPtsPKGstY
P24928	Y1909	Sugiyama	POLR2A POLR2	sPtsPtysPtsPVytPtsPKysPtsPtysPtsPKysPtsPt
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25685	S149	SIGNOR\|EPSD\|PSP	DNAJB1 DNAJ1 HDJ1 HSPF1	DPFSGFPMGMGGFTNVNFGRsRsAQEPARKKQDPPVTHDLR
P25685	S151	SIGNOR\|EPSD\|PSP	DNAJB1 DNAJ1 HDJ1 HSPF1	FSGFPMGMGGFTNVNFGRsRsAQEPARKKQDPPVTHDLRVs
P25685	S171	SIGNOR\|EPSD\|PSP	DNAJB1 DNAJ1 HDJ1 HSPF1	sAQEPARKKQDPPVTHDLRVsLEEIysGCtKKMKISHKRLN
P25705	S65	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	KtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARVH
P26038	S527	Sugiyama	MSN	ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038	T465	Sugiyama	MSN	WQQKAQMVQEDLEKTRAELKtAMstPHVAEPAENEQDEQDE
P26232	T653	Sugiyama	CTNNA2 CAPR	PEELEDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMA
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T107	Sugiyama	RPL13 BBC1 OK/SW-cl.46	HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26639	S702	Sugiyama	TARS1 TARS	ISGTVNIRTRDNKVHGERtIsEtIERLQQLKEFRSKQAEEE
P27695	S143	Sugiyama	APEX1 APE APE1 APEX APX HAP1 REF1	sDKEGysGVGLLsRQCPLKVsyGIGDEEHDQEGRVIVAEFD
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29401	S305	Sugiyama	TKT	LAtPPQEDAPsVDIANIRMPsLPsyKVGDKIATRKAYGQAL
P29692	S162	Sugiyama	EEF1D EF1D	AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692	S86	Sugiyama	EEF1D EF1D	GPGAssGtsGDHGELVVRIAsLEVENQsLRGVVQELQQAIs
P29966	S27	Sugiyama	MARCKS MACS PRKCSL	KTAAKGEAAAERPGEAAVAssPsKANGQENGHVKVNGDAsP
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30050	T135	Sugiyama	RPL12	QMRHRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDI
P30101	S443	Sugiyama	PDIA3 ERP57 ERP60 GRP58	LsKDPNIVIAKMDAtANDVPsPyEVRGFPtIyFsPANKKLN
P30533	S242	Sugiyama	LRPAP1 A2MRAP	TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30533	S247	Sugiyama	LRPAP1 A2MRAP	KLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQSA
P31152	S186	SIGNOR	MAPK4 ERK4 PRKM4	IGDFGLARIVDQHYSHKGYLsEGLVTKWYRsPRLLLSPNNY
P31327	T45	Sugiyama	CPS1	AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P31943	S104	Sugiyama	HNRNPH1 HNRPH HNRPH1	EVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P31946	S132	Sugiyama	YWHAB	TQPESKVFyLKMKGDYFRyLsEVAsGDNKQTtVsNsQQAyQ
P32119	S112	Sugiyama	PRDX2 NKEFB TDPX1	KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P32119	T142	Sugiyama	PRDX2 NKEFB TDPX1	EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P32969	S137	Sugiyama	RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9	FLGEKYIRRVRMRPGVACsVsQAQKDELILEGNDIELVSNS
P33176	S57	Sugiyama	KIF5B KNS KNS1	DTVVIASKPYAFDRVFQSsTsQEQVyNDCAKKIVKDVLEGy
P33527	S915	Sugiyama	ABCC1 MRP MRP1	QMENGMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQ
P34897	T420	Sugiyama	SHMT2	LELVSITANKNTCPGDRsAItPGGLRLGAPALtSRQFREDD
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932	S76	Sugiyama	HSPA4 APG2 HSPH2	VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35221	T654	Sugiyama	CTNNA1	tPEELDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMA
P35241	S533	Sugiyama	RDX	ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35613	S279	Sugiyama	BSG UNQ6505/PRO21383	TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P35637	S346	Sugiyama	FUS TLS	TDRETGKLKGEAtVsFDDPPsAKAAIDWFDGKEFsGNPIKV
P36578	S365	Sugiyama	RPL4 RPL1	RNHKLRVDKAAAAAAALQAKsDEKAAVAGKKPVVGKKGKKA
P36578	S55	Sugiyama	RPL4 RPL1	DIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVAR
P36578	S63	Sugiyama	RPL4 RPL1	NLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGG
P36578	S66	Sugiyama	RPL4 RPL1	KNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHR
P36915	S68	Sugiyama	GNL1 HSR1	tDtsDGEsVTHHIRRLNQQPsQGLGPRGYDPNRYRLHFERD
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646	S549	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	IVHVSAKDKGTGREQQIVIQssGGLsKDDIENMVKNAEKYA
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T87	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P40222	S514	Sugiyama	TXLNA TXLN	GsLtDsGPERRPEGPGAQAPssPRVtEAPCyPGAPSTEASG
P41091	S107	Sugiyama	EIF2S3 EIF2G	KIYKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLV
P41091	T109	Sugiyama	EIF2S3 EIF2G	YKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLVRH
P41212	S439	Sugiyama	ETV6 TEL TEL1	FMKTPDEIMSGRTDRLEHLEsQELDEQIyQEDEC_______
P42704	S1027	Sugiyama	LRPPRC LRP130	VPFDVPELWyEDEKHsLNsssAsttEPDFQKDILIACRLNQ
P42704	S742	Sugiyama	LRPPRC LRP130	CRHDKVEDALNLKEEFDRLDssAVLDTGKYVGLVRVLAKHG
P43034	S152	Sugiyama	PAFAH1B1 LIS1 MDCR MDS PAFAHA	IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013	S308	Sugiyama	MKI67	VSRKSRPKsGGsGHAVAEPAsPEQELDQNKGKGRDVEsVQt
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777	S172	Sugiyama	RPL5 MSTP030	RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46777	S230	Sugiyama	RPL5 MSTP030	yLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAAIREN
P47712	S727	SIGNOR\|iPTMNet\|EPSD\|Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47756	S192	Sugiyama	CAPZB	TVMLWLQTNKSGsGtMNLGGsLtRQMEKDEtVsDCsPHIAN
P48643	S270	Sugiyama	CCT5 CCTE KIAA0098	ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49368	S244	Sugiyama	CCT3 CCTG TRIC5	VTHPRMRRYIKNPRIVLLDssLEyKKGEsQtDIEITREEDF
P49368	S252	Sugiyama	CCT3 CCTG TRIC5	YIKNPRIVLLDssLEyKKGEsQtDIEITREEDFTRILQMEE
P49588	S249	Sugiyama	AARS1 AARS	ILKPLPKKsIDtGMGLERLVsVLQNKMSNYDTDLFVPYFEA
P50395	S396	Sugiyama	GDI2 RABGDIB	IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50454	S138	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	LSNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEH
P50454	S139	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P50454	S141	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	STARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHSKI
P50502	S181	Sugiyama	ST13 AAG2 FAM10A1 HIP SNC6	LQKPNAAIRDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
P52298	S13	Sugiyama	NCBP2 CBP20 PIG55	________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52597	S265	Sugiyama	HNRNPF HNRPF	EySGLSDGYGFTTDLFGRDLsyCLsGMyDHRYGDsEFtVQs
P52597	S269	Sugiyama	HNRNPF HNRPF	LSDGYGFTTDLFGRDLsyCLsGMyDHRYGDsEFtVQsTTGH
P52907	S123	Sugiyama	CAPZA1	KEAsDPQPEEADGGLKsWREsCDsALRAYVKDHYSNGFCTV
P52907	S219	Sugiyama	CAPZA1	YEDGNVQLVSHKDVQDsLtVsNEAQtAKEFIKIIENAENEy
P52948	S623	Sugiyama	NUP98 ADAR2	KNLNNsNLFsPVNRDsENLAsPsEyPENGERFsFLSKPVDE
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396	S457	Sugiyama	ACLY	FLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQD
P53992	S378	Sugiyama	SEC24C KIAA0079	TTNFLVKDQGNASPRYIRCTsyNIPCTSDMAKQAQVPLAAV
P53999	S118	Sugiyama	SUB1 PC4 RPO2TC1	PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999	S12	Sugiyama	SUB1 PC4 RPO2TC1	_________MPKSKELVsssssGsDsDsEVDKKLKRKKQVA
P53999	S56	Sugiyama	SUB1 PC4 RPO2TC1	PVKKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRD
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55036	S266	Sugiyama	PSMD4 MCB1	AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55060	S342	Sugiyama	CSE1L CAS XPO2	ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF
P55072	S459	Sugiyama	VCP HEL-220 HEL-S-70	AEVMNSLAVTMDDFRWALSQsNPSALRETVVEVPQVTWEDI
P55072	S765	Sugiyama	VCP HEL-220 HEL-S-70	RsVsDNDIRKyEMFAQtLQQsRGFGsFRFPsGNQGGAGPsQ
P55081	S132	Sugiyama	MFAP1	VVGEsDsEVEGDAWRMEREDssEEEEEEIDDEEIERRRGMM
P55081	S133	Sugiyama	MFAP1	VGEsDsEVEGDAWRMEREDssEEEEEEIDDEEIERRRGMMR
P55795	S104	Sugiyama	HNRNPH2 FTP3 HNRPH2	EVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S239	Sugiyama	ACTB	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	Y240	Sugiyama	ACTB	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60842	S394	Sugiyama	EIF4A1 DDX2A EIF4A	NMVTEEDKRTLRDIEtFyNtsIEEMPLNVADLI________
P60900	S175	Sugiyama	PSMA6 PROS27	DPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTV
P60900	T173	Sugiyama	PSMA6 PROS27	KCDPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQ
P61221	Y594	Sugiyama	ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40	RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61247	S236	Sugiyama	RPS3A FTE1 MFTL	KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247	S237	Sugiyama	RPS3A FTE1 MFTL	MLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyE
P61313	S100	Sugiyama	RPL15 EC45 TCBAP0781	tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61313	S97	Sugiyama	RPL15 EC45 TCBAP0781	KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61758	T45	Sugiyama	VBP1 PFDN3	IPEAVFVEDVDSFMKQPGNEtADtVLKKLDEQYQKYKFMEL
P61916	S29	Sugiyama	NPC2 HE1	LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	S38	Sugiyama	YWHAG	ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62266	S45	Sugiyama	RPS23	KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62736	S241	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	Y242	Sugiyama	ACTA2 ACTSA ACTVS GIG46	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917	S138	Sugiyama	RPL8	EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942	S9	Sugiyama	FKBP1A FKBP1 FKBP12	____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P62979	S134	Sugiyama	RPS27A UBA80 UBCEP1	IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63010	S531	Sugiyama	AP2B1 ADTB2 CLAPB1	TQDSDNPDLRDRGyIyWRLLsTDPVTAKEVVLSEKPLISEE
P63104	S145	Sugiyama	YWHAZ	YYRyLAEVAAGDDKKGIVDQsQQAyQEAFEIsKKEMQPTHP
P63104	S156	Sugiyama	YWHAZ	DDKKGIVDQsQQAyQEAFEIsKKEMQPTHPIRLGLALNFSV
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63167	S21	Sugiyama	DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1	MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S239	Sugiyama	ACTG1 ACTG	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	Y240	Sugiyama	ACTG1 ACTG	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267	S240	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	Y241	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809	S209	Sugiyama	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68032	S241	Sugiyama	ACTC1 ACTC	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	Y242	Sugiyama	ACTC1 ACTC	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133	S241	Sugiyama	ACTA1 ACTA	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	Y242	Sugiyama	ACTA1 ACTA	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P78345	S253	Sugiyama	RPP38	DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P78371	S143	Sugiyama	CCT2 99D8.1 CCTB	PQTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIA
P78371	S150	Sugiyama	CCT2 99D8.1 CCTB	WREATKAAREALLssAVDHGsDEVKFRQDLMNIAGTTLssK
P78527	S3366	Sugiyama	PRKDC HYRC HYRC1	ACLAEIEEDKARRILELsGsssEDsEKVIAGLyQRAFQHLS
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P99999	S48	Sugiyama	CYCS CYC	KTGPNLHGLFGRKtGQAPGysytAANKNKGIIWGEDTLMEY
Q00341	S904	Sugiyama	HDLBP HBP VGL	FHRSVMGPKGSRIQQITRDFsVQIKFPDREENAVHSTEPVV
Q01105	S161	Sugiyama	SET	FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105	S168	Sugiyama	SET	ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105	T169	Sugiyama	SET	NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01650	S31	Sugiyama	SLC7A5 CD98LC LAT1 MPE16	LAAPAAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNIT
Q01650	S35	Sugiyama	SLC7A5 CD98LC LAT1 MPE16	AAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNITLLNG
Q05397	S677	Sugiyama	PTK2 FAK FAK1	KCWAYDPSRRPRFTELKAQLsTILEEEKAQQEERMRMEsRR
Q06124	S140	Sugiyama	PTPN11 PTP2C SHPTP2	KEAEKLLTEKGKHGsFLVREsQsHPGDFVLSVRTGDDKGES
Q06830	S152	Sugiyama	PRDX1 PAGA PAGB TDPX2	IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q06830	T143	Sugiyama	PRDX1 PAGA PAGB TDPX2	EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q06830	T156	Sugiyama	PRDX1 PAGA PAGB TDPX2	KGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEVCPAG
Q07021	S210	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q07157	S1111	Sugiyama	TJP1 ZO1	WsyYDDKQPYPsRPPFDNQHsQDLDSRQHPEESSERGyFPR
Q07666	S35	Sugiyama	KHDRBS1 SAM68	sGRsGsMDPsGAHPsVRQtPsRQPPLPHRSRGGGGGSRGGA
Q07866	S460	Sugiyama	KLC1 KLC KNS2	QKDGTsFGEyGGWyKACKVDsPtVTTtLKNLGALyRRQGKF
Q08AD1	S1313	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	sLNtGDNEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWE
Q08AD1	S464	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q09028	S147	Sugiyama	RBBP4 RBAP48	VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q09666	T3716	Sugiyama	AHNAK PM227	VEGDLKGPEVDIKGPKVDIDtPDINIEGsEGKFKGPKFKIP
Q09666	T4100	Sugiyama	AHNAK PM227	VDVNLPKADIDVsGPKVDIDtPDIDIHGPEGKLKGPKFKMP
Q10567	S531	Sugiyama	AP1B1 ADTB1 BAM22 CLAPB2	TQDSDNPDLRDRGyIyWRLLsTDPVAAKEVVLAEKPLISEE
Q12931	S568	Sugiyama	TRAP1 HSP75 HSPC5	ISVETDIVVDHYKEEKFEDRsPAAECLSEKETEELMAWMRN
Q12965	S1002	Sugiyama	MYO1E MYO1C	RSNQKSLyTsMARPPLPRQQstssDRVsQtPEsLDFLKVPD
Q13247	S297	Sugiyama	SRSF6 SFRS6 SRP55	RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q13283	S231	Sugiyama	G3BP1 G3BP	QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13596	S368	Sugiyama	SNX1	AKSLAMLGSSEDNTALSRALsQLAEVEEKIEQLHQEQANND
Q13884	S87	Sugiyama	SNTB1 SNT2B1	SFCRGAGAGHPGAGGAQPPDsPAGVRTAFTDLPEQVPESIS
Q14103	T193	Sugiyama	HNRNPD AUF1 HNRPD	KAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVESIEL
Q14126	S551	Sugiyama	DSG2 CDHF5	FSVIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFL
Q14152	S492	Sugiyama	EIF3A EIF3S10 KIAA0139	VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14204	S2384	Sugiyama	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	FSEDVLSTDMIFNNFLARLRsIPLDEGEDEAQRRRKGKEDE
Q14247	S282	Sugiyama	CTTN EMS1	QKDyKTGFGGKFGVQsERQDsAAVGFDyKEKLAKHEsQQDy
Q14247	S405	Sugiyama	CTTN EMS1	EEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVyEDAA
Q14568	S50	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14677	S166	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14738	S598	Sugiyama	PPP2R5D	DVyTIKALEAHKRAEEFLTAsQEAL________________
Q14980	S1757	Sugiyama	NUMA1 NMP22 NUMA	ITSKLPRtQPDGtsVPGEPAsPIsQRLPPKVEsLEsLyFtP
Q15021	S1330	Sugiyama	NCAPD2 CAPD2 CNAP1 KIAA0159	sQRAPsAKKPSTGSRyQPLAstAsDNDFVtPEPRRTTRRHP
Q15293	S315	Sugiyama	RCN1 RCN	NKDEKLTKEEILENWNMFVGsQAtNyGEDLtKNHDEL____
Q15293	T76	Sugiyama	RCN1 RCN	FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15382	S130	SIGNOR\|EPSD\|PSP	RHEB RHEB2	VQIPIMLVGNKKDLHMERVIsYEEGKALAEsWNAAFLEssA
Q15642	T302	Sugiyama	TRIP10 CIP4 STOT STP	VEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRTKRWP
Q15759	S32	Sugiyama	MAPK11 PRKM11 SAPK2 SAPK2B	ELNKTVWEVPQRLQGLRPVGsGAyGsVCsAyDARLRQKVAV
Q15759	S40	Sugiyama	MAPK11 PRKM11 SAPK2 SAPK2B	VPQRLQGLRPVGsGAyGsVCsAyDARLRQKVAVKKLSRPFQ
Q15759	T180	Sugiyama	MAPK11 PRKM11 SAPK2 SAPK2B	EDCELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHY
Q15759	Y182	Sugiyama	MAPK11 PRKM11 SAPK2 SAPK2B	CELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHYNQ
Q15818	S91	Sugiyama	NPTX1	TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP
Q16204	S244	Sugiyama	CCDC6 D10S170 TST1	LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q16204	S323	Sugiyama	CCDC6 D10S170 TST1	RLQRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQ
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16576	S146	Sugiyama	RBBP7 RBAP46	VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16630	T157	Sugiyama	CPSF6 CFIM68	SKKLMDLLPKRELHGQNPVVtPCNKQFLsQFEMQSRKTTQS
Q2KHR3	S1231	Sugiyama	QSER1	sPsDKVDNELKNLEHLssFssDEDDPGYSQDAYKSVstPLT
Q2VIQ3	S1038	Sugiyama	KIF4B	FEYIPPKPKPSRVKEKFLEQsMDIEDLKYCSEHSVNEHEDG
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3MII6	S506	Sugiyama	TBC1D25 OATL1	DHLATASQGPGGGGRLLRQAsLDGLQQLRDNMGSRRDPLVQ
Q53EL6	S94	Sugiyama	PDCD4 H731	GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q53EL6	T93	Sugiyama	PDCD4 H731	RGDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLP
Q562R1	S240	Sugiyama	ACTBL2	VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q562R1	Y241	Sugiyama	ACTBL2	ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF7	S408	Sugiyama	HSP90AB3P HSP90BC	EPIDEYCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEE
Q58FF8	S308	Sugiyama	HSP90AB2P HSP90BB	YMTEPIDGYQLKEFDGKsLVsVtKEGLELPEDGEEKKRMEE
Q5H9R7	S579	Sugiyama	PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3	IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q5T4S7	S178	Sugiyama	UBR4 KIAA0462 KIAA1307 RBAF600	AKLPQTVKTLSDVEDQKELAsPVsPELRQKEVQMNFLNQLT
Q6GYQ0	T798	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6PKG0	S774	Sugiyama	LARP1 KIAA0731 LARP	LFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtPQLKDS
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3	S939	Sugiyama	POTEE A26C1A POTE2	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6S8J3	Y940	Sugiyama	POTEE A26C1A POTE2	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71RC2	S74	Sugiyama	LARP4 PP13296	PEGNAELSEDICKEYEVMySssCETTRNTTGIEESTDGMIL
Q71RC2	S75	Sugiyama	LARP4 PP13296	EGNAELSEDICKEYEVMySssCETTRNTTGIEESTDGMILG
Q7L2J0	S216	Sugiyama	MEPCE BCDIN3	NLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDIt
Q7L2J0	T213	Sugiyama	MEPCE BCDIN3	DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q7LBC6	S810	Sugiyama	KDM3B C5orf7 JHDM2B JMJD1B KIAA1082	PFEAVKRFsLDERSLACRQDsDSSTNsDLSDLSDSEEQLQA
Q7Z2W4	S364	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	PGstyLASNsTsAPNWKsLtsWtNDQGARRKtVFsPtLPAA
Q7Z417	S692	Sugiyama	NUFIP2 KIAA1321 PIG1	IWNLQKQDPKRIItyNEAMDsPDQ_________________
Q7Z5K2	S223	Sugiyama	WAPL FOE KIAA0261 WAPAL	EIKETNDTWNSQFGKRPEsPsEIsPIKGsVRTGLFEWDNDF
Q86U86	S948	Sugiyama	PBRM1 BAF180 PB1	AEKsEDssGAAGLSGLHRtYsQDCsFKNSMYHVGDYVYVEP
Q86UF2	S140	Sugiyama	CTAGE6 CTAGE6P	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86W56	S286	Sugiyama	PARG	VGSEDVGTGPKNDNKLTRQEsCLGNsPPFEKESEPEsPMDV
Q86YP4	S114	Sugiyama	GATAD2A	SERRPPsPDVIVLsDNEQPssPRVNGLttVALKETSTEALM
Q8IW41	S206	Sugiyama	MAPKAPK5 PRAK	tPyYVAPQVLEAQRRHQKEKsGIIPtsPtPYTYNKSCDLWS
Q8IW41	S212	Sugiyama	MAPKAPK5 PRAK	PQVLEAQRRHQKEKsGIIPtsPtPYTYNKSCDLWSLGVIIY
Q8IW41	S33	Sugiyama	MAPKAPK5 PRAK	ETSILEEYSINWTQKLGAGIsGPVRVCVKKSTQERFALKIL
Q8IW41	S386	Sugiyama	MAPKAPK5 PRAK	LGTKPKDSVYIHDHENGAEDsNVALEKLRDVIAQCILPQAG
Q8IW41	S438	Sugiyama	MAPKAPK5 PRAK	VMQEAWKYNRECKLLRDTLQsFsWNGRGFTDKVDRLKLAEI
Q8IW41	S440	Sugiyama	MAPKAPK5 PRAK	QEAWKYNRECKLLRDTLQsFsWNGRGFTDKVDRLKLAEIVK
Q8IW41	T182	Sugiyama	MAPKAPK5 PRAK	DAPVKLCDFGFAKIDQGDLMtPQFtPyYVAPQVLEAQRRHQ
Q8IW41	T186	Sugiyama	MAPKAPK5 PRAK	KLCDFGFAKIDQGDLMtPQFtPyYVAPQVLEAQRRHQKEKs
Q8IW41	T211	Sugiyama	MAPKAPK5 PRAK	APQVLEAQRRHQKEKsGIIPtsPtPYTYNKSCDLWSLGVII
Q8IW41	Y188	Sugiyama	MAPKAPK5 PRAK	CDFGFAKIDQGDLMtPQFtPyYVAPQVLEAQRRHQKEKsGI
Q8IWX8	S904	Sugiyama	CHERP DAN26 SCAF6	KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IX94	S140	Sugiyama	CTAGE4	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8IZ21	S590	Sugiyama	PHACTR4 PRO2963	SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8N201	S495	Sugiyama	INTS1 KIAA1440 UNQ1821/PRO3434	KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N556	S264	Sugiyama	AFAP1 AFAP	IKEAYSGCSGPVDSECPPPPssPVHKAELEKKLssERPssD
Q8N8S7	S125	Sugiyama	ENAH MENA	MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBJ5	S612	Sugiyama	COLGALT1 GLT25D1 PSEC0241	QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBS9	S426	Sugiyama	TXNDC5 TLP46 UNQ364/PRO700	KKVSEHSGGRDLDSLHRFVLsQAKDEL______________
Q8ND56	S300	Sugiyama	LSM14A C19orf13 FAM61A RAP55 RAP55A	GRFGIRRDGPMKFEKDFDFEsANAQFNKEEIDREFHNKLKL
Q8NFI4	S181	Sugiyama	ST13P5 FAM10A5	LQKPNAAIQDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
Q8NI08	S208	Sugiyama	NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993	DKLPDADLARKALKPIERVLsstsEEDEPGVVKFLKMNCRY
Q8WUI4	S109	Sugiyama	HDAC7 HDAC7A	LAEVILKKQQAALERtVHPNsPGIPYRTLEPLETEGATRSM
Q8WUM0	S309	Sugiyama	NUP133	LTSSNISKWELDDSSEKHAYsWDINRALKENITDAIWGSES
Q8WX93	S479	Sugiyama	PALLD KIAA0992 CGI-151	VLECRVRGAPPLQVQWFRQGsEIQDsPDFRILQKKPRSTAE
Q8WXH0	S2781	Sugiyama	SYNE2 KIAA1011 NUA	ILSQIRKCKVTHDGILARQQsVEsLAEEVKDKVPSLTTYEG
Q8WYL5	S441	Sugiyama	SSH1 KIAA1298 SSH1L	NYVKQKRSITRPNAGFMRQLsEYEGILDASKQRHNKLWRQQ
Q92499	S113	Sugiyama	DDX1	MNPYDRGSAFAIGSDGLCCQsREVKEWHGCRATKGLMKGKH
Q92599	S163	EPSD\|PSP	SEPTIN8 KIAA0202 SEPT8	FDYHDTRIHVCLYFITPTGHsLKSLDLVTMKKLDSKVNIIP
Q92599	S192	EPSD\|PSP	SEPTIN8 KIAA0202 SEPT8	MKKLDSKVNIIPIIAKADTIsKSELHKFKIKIMGELVSNGV
Q92614	S728	Sugiyama	MYO18A CD245 KIAA0216 MYSPDZ TIAF1	ELSSAIFKHQHKGGTLQRstsFRQGPEEsGLGDGTGPKLSA
Q92804	S295	Sugiyama	TAF15 RBP56 TAF2N	TDKDTGKPKGEAtVsFDDPPsAKAAIDWFDGKEFHGNIIKV
Q92945	S181	Sugiyama	KHSRP FUBP2	GRGGEQINKIQQDSGCKVQIsPDsGGLPERsVsLtGAPEsV
Q96C19	S74	Sugiyama	EFHD2 SWS1	ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96C86	T25	Sugiyama	DCPS DCS1 HINT5 HSPC015	APQLGKRKRELDVEEAHAAstEEKEAGVGNGTCAPVRLPFS
Q96D46	S462	Sugiyama	NMD3 CGI-07	FLEDLEEDEAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAE
Q96E11	S239	Sugiyama	MRRF	LKKSKDTVsEDtIRLIEKQIsQMADDtVAELDRHLAVKTKE
Q96IR7	S360	Sugiyama	HPDL GLOXD1	LIQRQGATGFGQGNIRALWQsVQEQsARSQEA_________
Q96MH2	S194	Sugiyama	HEXIM2 L3	EAGDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELV
Q96MH2	T196	Sugiyama	HEXIM2 L3	GDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELVRD
Q96S55	T116	Sugiyama	WRNIP1 WHIP	GEEGDDGGETESREsyDAPPtPsGARLIPDFPVARsssPGR
Q99426	S110	Sugiyama	TBCB CG22 CKAP1	HsGARLGEyEDVSRVEKytIsQEAyDQRQDtVRSFLKRsKL
Q99426	S76	Sugiyama	TBCB CG22 CKAP1	LYGVDDKFYsKLDQEDALLGsYPVDDGCRIHVIDHsGARLG
Q99497	S57	Sugiyama	PARK7	GLAGKDPVQCsRDVVICPDAsLEDAKKEGPyDVVVLPGGNL
Q99543	S275	Sugiyama	DNAJC2 MPHOSPH11 MPP11 ZRF1	RAQRKKEEMNRIRtLVDNAysCDPRIKKFKEEEKAKKEAEK
Q9BQE3	S439	Sugiyama	TUBA1C TUBA6	SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQG0	S11	Sugiyama	MYBBP1A P160	__________MEsRDPAQPMsPGEAtQsGARPADRYGLLKH
Q9BVC4	S43	Sugiyama	MLST8 GBL LST8	TVRFWQAHSGICTRTVQHQDsQVNALEVTPDRSMIAAAGYQ
Q9BW71	S357	Sugiyama	HIRIP3	EDsGKGEPTAKGSRKMARLGstsGEEsDLEREVsDsEAGGG
Q9BYX7	S239	Sugiyama	POTEKP ACTBL3 FKSG30	VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7	Y240	Sugiyama	POTEKP ACTBL3 FKSG30	ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BZD4	S171	Sugiyama	NUF2 CDCA1 NUF2R	KMQQLNAAHQEALMKLERLDsVPVEEQEEFKQLSDGIQELQ
Q9C0C9	S399	Sugiyama	UBE2O KIAA1734	EGsMAKKVKRLLKKQVVRIMsCsPDtQCsRDHsMEDPDKKG
Q9GZZ9	S44	Sugiyama	UBA5 UBE1DC1	sLQVPRSGDGGGGRVRIEKMssEVVDSNPysRLMALKRMGI
Q9H0K1	T589	Sugiyama	SIK2 KIAA0781 QIK SNF1LK2	KREVHNRsPVsFREGRRAsDtsLtQGIVAFRQHLQNLARTK
Q9H0K1	T592	Sugiyama	SIK2 KIAA0781 QIK SNF1LK2	VHNRsPVsFREGRRAsDtsLtQGIVAFRQHLQNLARTKGIL
Q9H2K8	S324	Sugiyama	TAOK3 DPK JIK KDS MAP3K18	QyRKMKKILFQETRNGPLNEsQEDEEDsEHGTsLNREMDSL
Q9H2U2	S315	Sugiyama	PPA2 HSPC124	ISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLGK_
Q9H3N1	S270	Sugiyama	TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268	EAEsKEGtNKDFPQNAIRQRsLGPsLAtDKs__________
Q9H4A3	S1261	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H4A3	S2029	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GPssDPEAAFLSRDVDDGsGsPHsPHQLssKSLPSQNLSQS
Q9H4A3	S2032	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	sDPEAAFLSRDVDDGsGsPHsPHQLssKSLPSQNLSQSLSN
Q9H4L5	S30	Sugiyama	OSBPL3 KIAA0704 ORP3 OSBP3	VSQKLVsPsRsTSSCSSKQGsRQDsWEVVEGLRGEMNYTQE
Q9H4L5	S34	Sugiyama	OSBPL3 KIAA0704 ORP3 OSBP3	LVsPsRsTSSCSSKQGsRQDsWEVVEGLRGEMNYTQEPPVQ
Q9H788	S315	Sugiyama	SH2D4A PPP1R38 SH2A	LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H814	S298	Sugiyama	PHAX RNUXA	NGSRRRTPGGVFLNLLKNtPsISEEQIKDIFyIENQKEYEN
Q9HAP6	S115	Sugiyama	LIN7B MALS2 VELI2 UNQ3116/PRO10200	ELPKTDEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLK
Q9NR30	S706	Sugiyama	DDX21	PTASVTEIQEKWHDSRRWQLsVATEQPELEGPREGYGGFRG
Q9NUP9	S115	Sugiyama	LIN7C MALS3 VELI3	ELPKTEEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLK
Q9NW68	S17	Sugiyama	BSDC1 UNQ2494/PRO5781	____MAEGEDVGWWRSWLQQsYQAVKEKSSEALEFMKRDLT
Q9NYF8	S198	Sugiyama	BCLAF1 BTF KIAA0164	PLKsKsQEEPKDtFEHDPsEsIDEFNKssAtsGDIWPGLsA
Q9UGV2	S361	Sugiyama	NDRG3	sPFsRsVtsNQsDGtQESCEsPDVLDRHQTMEVsC______
Q9UHB6	S490	Sugiyama	LIMA1 EPLIN SREBP3 PP624	ENEEILERPAQLANAREtPHsPGVEDAPIAKVGVLAAsMEA
Q9UHD2	S510	Sugiyama	TBK1 NAK	LEAAELGEISDIHTKLLRLsssQGTIETSLQDIDSRLsPGG
Q9UHI6	S647	Sugiyama	DDX20 DP103 GEMIN3	QNGFVRNKVIEQRVPVLASSsQsGDsEsDSDSySSRTSSQS
Q9UHX1	S461	Sugiyama	PUF60 FIR ROBPI SIAHBP1	sIsGssARHMVMQKLLRKQEsTVMVLRNMVDPKDIDDDLEG
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UKS6	S341	Sugiyama	PACSIN3	DEVtLtsIVPTRDGTAPPPQsPGsPGtGQDEEWsDEEsPRK
Q9UKV3	S987	Sugiyama	ACIN1 ACINUS KIAA0670	EVKKVTLGDtLtRRsIsQQKsGVsITIDDPVRtAQVPsPPR
Q9UKV3	S990	Sugiyama	ACIN1 ACINUS KIAA0670	KVTLGDtLtRRsIsQQKsGVsITIDDPVRtAQVPsPPRGKI
Q9UKV8	S387	Sugiyama	AGO2 EIF2C2	ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9ULD2	S1203	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9ULD2	T1204	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	ENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRLs
Q9UNF1	S265	Sugiyama	MAGED2 BCG1	LRsPKARRGKARRRAAKLQssQEPEAPPPRDVALLQGRAND
Q9UNH7	S316	Sugiyama	SNX6	LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UPN3	S2769	Sugiyama	MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251	EAIEKRLISPELANMIQIDSsEFSDHRAQIEKQEGIEVCAL
Q9UQ35	S2692	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y2B0	S178	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	NVKDKLCSKRtDLCDHALHIsHDEL________________
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2U5	S239	Sugiyama	MAP3K2 MAPKKK2 MEKK2	SLDSPLDGESYPKSRMPRAQsyPDNHQEFSDyDNPIFEKFG
Q9Y3X0	S386	Sugiyama	CCDC9	DRWETKEGAAsPAPEtPQPtsPEtsPKETPMQPPEIPAPAH
Q9Y3X0	T381	Sugiyama	CCDC9	YsDHDDRWETKEGAAsPAPEtPQPtsPEtsPKETPMQPPEI
Q9Y4X5	S514	Sugiyama	ARIH1 ARI MOP6 UBCH7BP HUSSY-27	NQADLENATEVLSGYLERDIsQDsLQDIKQKVQDKYRYCES
Q9Y580	S136	Sugiyama	RBM7	RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Q9Y5B9	S650	Sugiyama	SUPT16H FACT140 FACTP140	KRYKTREAEEKEKEGIVKQDsLVINLNRsNPKLKDLYIRPN
Q9Y5S9	S56	Sugiyama	RBM8A RBM8 HSPC114 MDS014	KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y6G9	S516	Sugiyama	DYNC1LI1 DNCLI1	HAELDRITRKPVtVsPttPtsPtEGEAs_____________

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Signal Transduction	R-HSA-162582	2.902434e-07	6.537	1	0
Post NMDA receptor activation events	R-HSA-438064	5.090464e-07	6.293	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.120924e-06	5.673	0	0
Death Receptor Signaling	R-HSA-73887	1.069165e-05	4.971	0	0
DAG and IP3 signaling	R-HSA-1489509	1.180282e-05	4.928	0	0
Nervous system development	R-HSA-9675108	1.767308e-05	4.753	0	0
Calmodulin induced events	R-HSA-111933	2.930482e-05	4.533	0	0
CaM pathway	R-HSA-111997	2.930482e-05	4.533	0	0
Axon guidance	R-HSA-422475	2.250303e-05	4.648	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.377862e-05	4.624	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	4.424535e-05	4.354	0	0
NRAGE signals death through JNK	R-HSA-193648	5.355520e-05	4.271	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	7.230441e-05	4.141	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	7.840394e-05	4.106	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	9.245223e-05	4.034	0	0
Apoptotic execution phase	R-HSA-75153	1.461330e-04	3.835	0	0
Ca-dependent events	R-HSA-111996	1.755367e-04	3.756	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.740453e-04	3.759	0	0
Oncogenic MAPK signaling	R-HSA-6802957	2.439055e-04	3.613	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.979196e-04	3.526	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	3.104296e-04	3.508	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.725865e-04	3.429	0	0
L1CAM interactions	R-HSA-373760	3.724709e-04	3.429	0	0
PLC beta mediated events	R-HSA-112043	3.887830e-04	3.410	0	0
Signaling by Hippo	R-HSA-2028269	4.264820e-04	3.370	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	4.520111e-04	3.345	0	0
Intracellular signaling by second messengers	R-HSA-9006925	5.056095e-04	3.296	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	5.622866e-04	3.250	0	0
Membrane Trafficking	R-HSA-199991	8.144774e-04	3.089	0	0
Rab regulation of trafficking	R-HSA-9007101	8.598134e-04	3.066	0	0
Neuronal System	R-HSA-112316	9.892952e-04	3.005	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	9.944540e-04	3.002	0	0
G-protein mediated events	R-HSA-112040	1.059998e-03	2.975	0	0
Recycling pathway of L1	R-HSA-437239	1.361643e-03	2.866	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.482753e-03	2.829	0	0
Long-term potentiation	R-HSA-9620244	1.655204e-03	2.781	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	1.759252e-03	2.755	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.945543e-03	2.711	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.945543e-03	2.711	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.945543e-03	2.711	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.820757e-03	2.740	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.945543e-03	2.711	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.117700e-03	2.674	0	0
Transmission across Chemical Synapses	R-HSA-112315	2.161844e-03	2.665	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.236081e-03	2.651	0	0
PKA activation	R-HSA-163615	2.236081e-03	2.651	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	2.427356e-03	2.615	0	0
Cell Cycle	R-HSA-1640170	2.445366e-03	2.612	0	0
Activation of RAC1	R-HSA-428540	2.595302e-03	2.586	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.642654e-03	2.578	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.661184e-03	2.575	0	0
Cell Cycle, Mitotic	R-HSA-69278	2.791891e-03	2.554	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	2.899418e-03	2.538	0	0
Rap1 signalling	R-HSA-392517	2.954055e-03	2.530	0	0
COPI-mediated anterograde transport	R-HSA-6807878	3.434278e-03	2.464	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	3.311288e-03	2.480	0	0
Deubiquitination	R-HSA-5688426	3.393680e-03	2.469	0	0
Mitotic G2-G2/M phases	R-HSA-453274	3.059992e-03	2.514	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.701747e-03	2.432	0	0
Meiotic synapsis	R-HSA-1221632	3.710666e-03	2.431	0	0
RAF activation	R-HSA-5673000	4.874371e-03	2.312	0	0
AURKA Activation by TPX2	R-HSA-8854518	4.699039e-03	2.328	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	4.927877e-03	2.307	0	0
CREB phosphorylation	R-HSA-199920	5.084894e-03	2.294	0	0
Ub-specific processing proteases	R-HSA-5689880	4.444681e-03	2.352	0	0
G alpha (12/13) signalling events	R-HSA-416482	4.867865e-03	2.313	0	0
Diseases of programmed cell death	R-HSA-9645723	4.348910e-03	2.362	0	0
Kinesins	R-HSA-983189	4.538637e-03	2.343	0	0
Interleukin-37 signaling	R-HSA-9008059	5.040880e-03	2.297	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	5.415508e-03	2.266	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	5.454146e-03	2.263	0	0
TNF signaling	R-HSA-75893	5.774538e-03	2.238	0	0
Trafficking of AMPA receptors	R-HSA-399719	6.129663e-03	2.213	0	0
MAPK family signaling cascades	R-HSA-5683057	5.947376e-03	2.226	1	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	6.237033e-03	2.205	0	0
G2/M DNA damage checkpoint	R-HSA-69473	6.171837e-03	2.210	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	6.390962e-03	2.194	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	6.390962e-03	2.194	0	0
PI Metabolism	R-HSA-1483255	6.542831e-03	2.184	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	6.993534e-03	2.155	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	6.993534e-03	2.155	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	6.993534e-03	2.155	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	6.820133e-03	2.166	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	6.820133e-03	2.166	0	0
Signaling by RAS mutants	R-HSA-6802949	6.993534e-03	2.155	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.620577e-03	2.179	0	0
PKA activation in glucagon signalling	R-HSA-164378	7.576196e-03	2.121	0	0
Mitotic Prometaphase	R-HSA-68877	7.391561e-03	2.131	0	0
Neurexins and neuroligins	R-HSA-6794361	7.356963e-03	2.133	0	0
G2/M Transition	R-HSA-69275	7.236653e-03	2.140	0	0
Muscle contraction	R-HSA-397014	7.265401e-03	2.139	0	0
Signaling by RAF1 mutants	R-HSA-9656223	7.633271e-03	2.117	0	0
Signaling by VEGF	R-HSA-194138	7.663721e-03	2.116	0	0
mTORC1-mediated signalling	R-HSA-166208	7.798449e-03	2.108	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	7.935646e-03	2.100	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	9.045609e-03	2.044	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	9.387534e-03	2.027	0	0
MTOR signalling	R-HSA-165159	8.920217e-03	2.050	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.855061e-03	2.053	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	9.851729e-03	2.006	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	9.949609e-03	2.002	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.047634e-02	1.980	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.047634e-02	1.980	0	0
mRNA Splicing	R-HSA-72172	1.058717e-02	1.975	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.078383e-02	1.967	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.124586e-02	1.949	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	1.170937e-02	1.931	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.179447e-02	1.928	0	0
Neurodegenerative Diseases	R-HSA-8863678	1.179447e-02	1.928	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.179447e-02	1.928	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.142481e-02	1.942	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.199813e-02	1.921	0	0
Netrin-1 signaling	R-HSA-373752	1.199983e-02	1.921	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.243428e-02	1.905	0	0
Aggrephagy	R-HSA-9646399	1.327080e-02	1.877	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.251928e-02	1.902	0	0
Ion homeostasis	R-HSA-5578775	1.258971e-02	1.900	0	0
M Phase	R-HSA-68886	1.259555e-02	1.900	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.329146e-02	1.876	1	1
Cellular Senescence	R-HSA-2559583	1.229453e-02	1.910	1	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.265380e-02	1.898	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.342807e-02	1.872	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.397687e-02	1.855	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.397687e-02	1.855	0	0
Signaling by ROBO receptors	R-HSA-376176	1.450296e-02	1.839	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.468931e-02	1.833	0	0
Cell Cycle Checkpoints	R-HSA-69620	1.479778e-02	1.830	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	1.494071e-02	1.826	0	0
PKMTs methylate histone lysines	R-HSA-3214841	1.537060e-02	1.813	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.676298e-02	1.776	0	0
TRP channels	R-HSA-3295583	1.714998e-02	1.766	0	0
Selective autophagy	R-HSA-9663891	1.620784e-02	1.790	0	0
Hedgehog 'off' state	R-HSA-5610787	1.810323e-02	1.742	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.821960e-02	1.739	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.845834e-02	1.734	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.851759e-02	1.732	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.872401e-02	1.728	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	2.031264e-02	1.692	0	0
Meiosis	R-HSA-1500620	2.033412e-02	1.692	0	0
Protein-protein interactions at synapses	R-HSA-6794362	2.033412e-02	1.692	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	2.040931e-02	1.690	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.040931e-02	1.690	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	2.169043e-02	1.664	0	0
Cardiac conduction	R-HSA-5576891	2.298053e-02	1.639	0	0
Apoptosis	R-HSA-109581	2.150272e-02	1.668	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	2.304357e-02	1.637	0	0
TBC/RABGAPs	R-HSA-8854214	2.318610e-02	1.635	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	2.326710e-02	1.633	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.399107e-02	1.620	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	2.409284e-02	1.618	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	2.470492e-02	1.607	0	0
Opioid Signalling	R-HSA-111885	2.546975e-02	1.594	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.556782e-02	1.592	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.624071e-02	1.581	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	2.630542e-02	1.580	1	0
Programmed Cell Death	R-HSA-5357801	2.643970e-02	1.578	0	0
Centrosome maturation	R-HSA-380287	2.647139e-02	1.577	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.860214e-02	1.544	0	0
DCC mediated attractive signaling	R-HSA-418885	2.917891e-02	1.535	0	0
HSF1-dependent transactivation	R-HSA-3371571	2.949497e-02	1.530	0	0
FOXO-mediated transcription	R-HSA-9614085	2.903873e-02	1.537	0	0
Signaling by PTK6	R-HSA-8848021	2.822036e-02	1.549	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.822036e-02	1.549	0	0
Chromatin modifying enzymes	R-HSA-3247509	2.752032e-02	1.560	0	0
Regulation of TP53 Activity	R-HSA-5633007	2.953320e-02	1.530	1	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	3.110239e-02	1.507	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	3.213965e-02	1.493	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.222962e-02	1.492	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	3.366096e-02	1.473	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.383375e-02	1.471	0	0
FLT3 Signaling	R-HSA-9607240	3.385241e-02	1.470	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	3.402493e-02	1.468	0	0
RAF/MAP kinase cascade	R-HSA-5673001	3.472924e-02	1.459	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.482468e-02	1.458	0	0
Autophagy	R-HSA-9612973	3.550515e-02	1.450	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	3.562870e-02	1.448	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.599808e-02	1.444	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.661456e-02	1.436	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	3.685541e-02	1.433	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	3.685541e-02	1.433	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	3.685541e-02	1.433	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	3.768280e-02	1.424	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	3.827722e-02	1.417	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	4.290846e-02	1.367	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	4.055030e-02	1.392	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	4.355290e-02	1.361	0	0
Type I hemidesmosome assembly	R-HSA-446107	4.545394e-02	1.342	0	0
RSK activation	R-HSA-444257	4.545394e-02	1.342	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.545394e-02	1.342	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	4.545394e-02	1.342	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	4.554611e-02	1.342	0	0
Transcription of the HIV genome	R-HSA-167172	4.600811e-02	1.337	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	4.742330e-02	1.324	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	4.807155e-02	1.318	0	0
Macroautophagy	R-HSA-1632852	4.808688e-02	1.318	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.811071e-02	1.318	0	0
Defective pyroptosis	R-HSA-9710421	4.830321e-02	1.316	0	0
Packaging Of Telomere Ends	R-HSA-171306	4.927726e-02	1.307	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	4.948864e-02	1.305	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	5.140937e-02	1.289	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	5.140937e-02	1.289	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.368075e-02	1.270	0	0
Formation of axial mesoderm	R-HSA-9796292	5.679702e-02	1.246	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.679702e-02	1.246	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	5.659973e-02	1.247	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	5.540920e-02	1.256	0	0
Separation of Sister Chromatids	R-HSA-2467813	5.662319e-02	1.247	0	0
Estrogen-dependent gene expression	R-HSA-9018519	5.433167e-02	1.265	0	0
Integrin signaling	R-HSA-354192	4.970185e-02	1.304	0	0
Cilium Assembly	R-HSA-5617833	5.202178e-02	1.284	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	4.970185e-02	1.304	0	0
NrCAM interactions	R-HSA-447038	5.368075e-02	1.270	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.679702e-02	1.246	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	5.249930e-02	1.280	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.495539e-02	1.260	0	0
Chromatin organization	R-HSA-4839726	5.730906e-02	1.242	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	5.876716e-02	1.231	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	5.997468e-02	1.222	0	0
HIV Transcription Elongation	R-HSA-167169	6.202088e-02	1.207	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	6.202088e-02	1.207	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	6.202088e-02	1.207	0	0
Polo-like kinase mediated events	R-HSA-156711	6.222368e-02	1.206	0	0
Ephrin signaling	R-HSA-3928664	6.222368e-02	1.206	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.222368e-02	1.206	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	6.222368e-02	1.206	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	6.222368e-02	1.206	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	6.222368e-02	1.206	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	7.354241e-02	1.133	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	7.354241e-02	1.133	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	7.354241e-02	1.133	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	7.354241e-02	1.133	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.294109e-02	1.137	0	0
DNA methylation	R-HSA-5334118	6.457792e-02	1.190	0	0
mRNA 3'-end processing	R-HSA-72187	6.361184e-02	1.196	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	6.361184e-02	1.196	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	6.992422e-02	1.155	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	6.649291e-02	1.177	0	0
MHC class II antigen presentation	R-HSA-2132295	7.390885e-02	1.131	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	7.144687e-02	1.146	0	0
cGMP effects	R-HSA-418457	6.879458e-02	1.162	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	6.879458e-02	1.162	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.912189e-02	1.160	0	0
Regulation of KIT signaling	R-HSA-1433559	6.879458e-02	1.162	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	7.354241e-02	1.133	0	0
Sensory processing of sound	R-HSA-9659379	6.652055e-02	1.177	0	0
Regulation of gene expression in beta cells	R-HSA-210745	6.457792e-02	1.190	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	6.371775e-02	1.196	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	7.354241e-02	1.133	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	6.364802e-02	1.196	0	0
Deadenylation of mRNA	R-HSA-429947	7.395911e-02	1.131	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.395911e-02	1.131	0	0
HATs acetylate histones	R-HSA-3214847	7.903344e-02	1.102	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	7.912035e-02	1.102	0	0
PRC2 methylates histones and DNA	R-HSA-212300	7.985060e-02	1.098	0	0
RET signaling	R-HSA-8853659	7.985060e-02	1.098	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	8.459784e-02	1.073	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	8.459784e-02	1.073	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	8.459784e-02	1.073	0	0
C6 deamination of adenosine	R-HSA-75102	8.459784e-02	1.073	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	8.459784e-02	1.073	0	0
Potassium transport channels	R-HSA-1296067	8.459784e-02	1.073	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	8.459784e-02	1.073	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	8.459784e-02	1.073	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	8.459784e-02	1.073	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	8.459784e-02	1.073	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	8.459784e-02	1.073	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	8.459784e-02	1.073	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	8.459784e-02	1.073	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	8.459784e-02	1.073	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	8.459784e-02	1.073	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	9.616343e-02	1.017	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	9.616343e-02	1.017	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	8.464640e-02	1.072	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	8.464640e-02	1.072	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	8.464640e-02	1.072	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	8.464640e-02	1.072	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.252773e-02	1.083	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	8.880831e-02	1.052	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.759779e-02	1.058	0	0
p75NTR signals via NF-kB	R-HSA-193639	8.208124e-02	1.086	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	8.597129e-02	1.066	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.519549e-02	1.021	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	9.616343e-02	1.017	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	8.372887e-02	1.077	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	8.434956e-02	1.074	0	0
Mitotic Anaphase	R-HSA-68882	9.323269e-02	1.030	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	8.098924e-02	1.092	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	9.616343e-02	1.017	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	8.208124e-02	1.086	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	8.098924e-02	1.092	0	0
PIP3 activates AKT signaling	R-HSA-1257604	8.278613e-02	1.082	0	0
Cleavage of the damaged purine	R-HSA-110331	8.880831e-02	1.052	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	9.412050e-02	1.026	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	9.412050e-02	1.026	0	0
Gap junction trafficking and regulation	R-HSA-157858	8.850797e-02	1.053	0	0
Reproduction	R-HSA-1474165	8.248543e-02	1.084	0	0
Nef and signal transduction	R-HSA-164944	9.616343e-02	1.017	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	9.567002e-02	1.019	1	1
Regulation of CDH1 Gene Transcription	R-HSA-9764560	9.453665e-02	1.024	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	9.662436e-02	1.015	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	9.723493e-02	1.012	0	0
G2/M Checkpoints	R-HSA-69481	9.824009e-02	1.008	0	0
Depurination	R-HSA-73927	9.833604e-02	1.007	0	0
EPHB-mediated forward signaling	R-HSA-3928662	1.024997e-01	0.989	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.031351e-01	0.987	0	0
Meiotic recombination	R-HSA-912446	1.054261e-01	0.977	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.075178e-01	0.969	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.075178e-01	0.969	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	1.075178e-01	0.969	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.094071e-01	0.961	0	0
NF-kB is activated and signals survival	R-HSA-209560	1.094642e-01	0.961	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.096082e-01	0.960	0	0
Amplification of signal from the kinetochores	R-HSA-141424	1.096082e-01	0.960	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.106643e-01	0.956	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.133935e-01	0.945	0	0
Defective SLC2A10 causes arterial tortuosity syndrome (ATS)	R-HSA-5619068	2.139347e-01	0.670	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.139347e-01	0.670	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.139347e-01	0.670	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.139347e-01	0.670	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.224580e-01	0.912	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.224580e-01	0.912	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	1.635047e-01	0.786	0	0
Regulation of gap junction activity	R-HSA-191650	1.635047e-01	0.786	0	0
HCN channels	R-HSA-1296061	1.635047e-01	0.786	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.635047e-01	0.786	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.635047e-01	0.786	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.635047e-01	0.786	0	0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	1.635047e-01	0.786	0	0
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	1.635047e-01	0.786	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	1.635047e-01	0.786	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.635047e-01	0.786	0	0
FGFR4 mutant receptor activation	R-HSA-1839128	3.030798e-01	0.518	0	0
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.030798e-01	0.518	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	3.030798e-01	0.518	0	0
NFG and proNGF binds to p75NTR	R-HSA-205017	3.030798e-01	0.518	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.030798e-01	0.518	0	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	3.030798e-01	0.518	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.030798e-01	0.518	0	0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.030798e-01	0.518	0	0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	3.030798e-01	0.518	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	3.030798e-01	0.518	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	3.030798e-01	0.518	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.030798e-01	0.518	0	0
MyD88 deficiency (TLR5)	R-HSA-5602680	3.030798e-01	0.518	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.030798e-01	0.518	0	0
Defective MMADHC causes MMAHCD	R-HSA-3359473	3.030798e-01	0.518	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.030798e-01	0.518	0	0
Intestinal infectious diseases	R-HSA-8942233	3.030798e-01	0.518	0	0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	3.030798e-01	0.518	0	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	3.030798e-01	0.518	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	1.212195e-01	0.916	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	1.212195e-01	0.916	0	0
PTK6 Expression	R-HSA-8849473	1.212195e-01	0.916	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	1.212195e-01	0.916	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.212195e-01	0.916	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.065295e-01	0.685	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.065295e-01	0.685	0	0
PTK6 Down-Regulation	R-HSA-8849472	2.065295e-01	0.685	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.065295e-01	0.685	0	0
IRS activation	R-HSA-74713	2.065295e-01	0.685	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	2.065295e-01	0.685	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.065295e-01	0.685	0	0
G2 Phase	R-HSA-68911	2.065295e-01	0.685	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.065295e-01	0.685	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	1.483615e-01	0.829	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	1.483615e-01	0.829	0	0
Formation of annular gap junctions	R-HSA-196025	1.483615e-01	0.829	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.483615e-01	0.829	0	0
p75NTR recruits signalling complexes	R-HSA-209543	1.296151e-01	0.887	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.772319e-01	0.751	0	0
ARMS-mediated activation	R-HSA-170984	1.772319e-01	0.751	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	1.772319e-01	0.751	0	0
Gap junction degradation	R-HSA-190873	1.772319e-01	0.751	0	0
Calcineurin activates NFAT	R-HSA-2025928	1.772319e-01	0.751	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.505565e-01	0.601	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	2.505565e-01	0.601	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.505565e-01	0.601	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	2.505565e-01	0.601	0	0
Phosphorylation of Emi1	R-HSA-176417	2.505565e-01	0.601	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.505565e-01	0.601	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	2.505565e-01	0.601	0	0
Signaling by MAPK mutants	R-HSA-9652817	2.505565e-01	0.601	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.821199e-01	0.418	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.821199e-01	0.418	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.821199e-01	0.418	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.821199e-01	0.418	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.821199e-01	0.418	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	3.821199e-01	0.418	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	3.821199e-01	0.418	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	2.074780e-01	0.683	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.292749e-01	0.888	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	1.739724e-01	0.760	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	1.739724e-01	0.760	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.948058e-01	0.530	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.948058e-01	0.530	0	0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	2.948058e-01	0.530	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	2.948058e-01	0.530	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.254929e-01	0.901	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	2.387609e-01	0.622	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	2.387609e-01	0.622	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.387609e-01	0.622	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	2.387609e-01	0.622	0	0
Spry regulation of FGF signaling	R-HSA-1295596	1.978600e-01	0.704	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	1.978600e-01	0.704	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	1.978600e-01	0.704	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	1.662131e-01	0.779	0	0
HIV elongation arrest and recovery	R-HSA-167287	1.202490e-01	0.920	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	1.202490e-01	0.920	0	0
Striated Muscle Contraction	R-HSA-390522	1.144188e-01	0.942	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.337175e-01	0.874	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	2.226653e-01	0.652	0	0
Phosphorylation of the APC/C	R-HSA-176412	2.226653e-01	0.652	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	2.707618e-01	0.567	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	2.707618e-01	0.567	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.386611e-01	0.470	0	0
Netrin mediated repulsion signals	R-HSA-418886	3.386611e-01	0.470	0	0
SOS-mediated signalling	R-HSA-112412	3.386611e-01	0.470	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	3.386611e-01	0.470	0	0
The NLRP1 inflammasome	R-HSA-844455	4.521998e-01	0.345	0	0
The IPAF inflammasome	R-HSA-844623	4.521998e-01	0.345	0	0
Defective MMACHC causes MAHCC	R-HSA-3359474	4.521998e-01	0.345	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	4.521998e-01	0.345	0	0
Axonal growth stimulation	R-HSA-209563	4.521998e-01	0.345	0	0
Invadopodia formation	R-HSA-8941237	4.521998e-01	0.345	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	4.521998e-01	0.345	0	0
Defective HPRT1 disrupts guanine and hypoxanthine salvage	R-HSA-9734281	4.521998e-01	0.345	0	0
Defective ABCA1 causes TGD	R-HSA-5682113	4.521998e-01	0.345	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.521998e-01	0.345	0	0
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	4.521998e-01	0.345	0	0
Defective GCLC causes HAGGSD	R-HSA-5578999	4.521998e-01	0.345	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.521998e-01	0.345	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.741673e-01	0.759	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.482207e-01	0.605	0	0
Nucleosome assembly	R-HSA-774815	1.120868e-01	0.950	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.120868e-01	0.950	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.302775e-01	0.885	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	1.302775e-01	0.885	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	3.031862e-01	0.518	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	3.031862e-01	0.518	0	0
Leading Strand Synthesis	R-HSA-69109	3.031862e-01	0.518	0	0
IRAK1 recruits IKK complex	R-HSA-937039	3.031862e-01	0.518	0	0
Polymerase switching	R-HSA-69091	3.031862e-01	0.518	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	3.031862e-01	0.518	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	3.031862e-01	0.518	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.031862e-01	0.518	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	3.031862e-01	0.518	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	3.031862e-01	0.518	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	3.031862e-01	0.518	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	3.031862e-01	0.518	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.657187e-01	0.781	0	0
Cristae formation	R-HSA-8949613	2.102765e-01	0.677	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.743613e-01	0.562	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	3.816430e-01	0.418	0	0
Activation of RAS in B cells	R-HSA-1169092	3.816430e-01	0.418	0	0
FGFR1b ligand binding and activation	R-HSA-190370	3.816430e-01	0.418	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.240999e-01	0.906	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.943169e-01	0.711	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.292408e-01	0.640	0	0
Formation of the Early Elongation Complex	R-HSA-113418	2.292408e-01	0.640	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	3.357664e-01	0.474	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.109503e-01	0.676	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.947332e-01	0.711	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	3.009272e-01	0.522	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	2.726112e-01	0.564	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.487210e-01	0.604	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.346392e-01	0.871	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	2.099767e-01	0.678	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	2.079981e-01	0.682	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.686471e-01	0.571	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.686471e-01	0.571	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.955023e-01	0.529	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	2.955023e-01	0.529	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.277653e-01	0.484	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	3.682628e-01	0.434	0	0
Removal of the Flap Intermediate	R-HSA-69166	3.682628e-01	0.434	0	0
Lipophagy	R-HSA-9613354	4.233857e-01	0.373	0	0
WNT mediated activation of DVL	R-HSA-201688	4.233857e-01	0.373	0	0
NADE modulates death signalling	R-HSA-205025	5.143349e-01	0.289	0	0
betaKlotho-mediated ligand binding	R-HSA-1307965	5.143349e-01	0.289	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.143349e-01	0.289	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	5.143349e-01	0.289	0	0
ATP sensitive Potassium channels	R-HSA-1296025	5.143349e-01	0.289	0	0
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	5.143349e-01	0.289	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	2.417598e-01	0.617	0	0
HIV Transcription Initiation	R-HSA-167161	2.417598e-01	0.617	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	2.417598e-01	0.617	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.582236e-01	0.588	0	0
HDACs deacetylate histones	R-HSA-3214815	2.327362e-01	0.633	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	3.095543e-01	0.509	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	4.004641e-01	0.397	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	4.004641e-01	0.397	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	4.004641e-01	0.397	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	2.750162e-01	0.561	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.636176e-01	0.334	0	0
Folding of actin by CCT/TriC	R-HSA-390450	4.636176e-01	0.334	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.636176e-01	0.334	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	4.636176e-01	0.334	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	2.760756e-01	0.559	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	3.094254e-01	0.509	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	2.999500e-01	0.523	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	4.321863e-01	0.364	0	0
Cellular response to heat stress	R-HSA-3371556	2.045819e-01	0.689	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	3.891316e-01	0.410	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	3.725086e-01	0.429	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.926628e-01	0.534	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	3.771587e-01	0.423	0	0
Late endosomal microautophagy	R-HSA-9615710	4.126004e-01	0.384	0	0
FGFR2 alternative splicing	R-HSA-6803529	4.351013e-01	0.361	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	4.632722e-01	0.334	0	0
Phase 2 - plateau phase	R-HSA-5576893	4.632722e-01	0.334	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	5.021446e-01	0.299	0	0
Signaling by APC mutants	R-HSA-4839744	5.021446e-01	0.299	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	5.021446e-01	0.299	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	5.021446e-01	0.299	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	5.021446e-01	0.299	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	5.021446e-01	0.299	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.829381e-01	0.548	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.829381e-01	0.548	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.359290e-01	0.361	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.359290e-01	0.361	0	0
Regulation of RAS by GAPs	R-HSA-5658442	3.983475e-01	0.400	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	4.935895e-01	0.307	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	4.935895e-01	0.307	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.854329e-01	0.414	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.871351e-01	0.312	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.388358e-01	0.269	0	0
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	5.388358e-01	0.269	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	5.388358e-01	0.269	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.388358e-01	0.269	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	5.388358e-01	0.269	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	4.001858e-01	0.398	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.521087e-01	0.345	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	5.230291e-01	0.281	0	0
Translation initiation complex formation	R-HSA-72649	4.698771e-01	0.328	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.418543e-01	0.355	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	5.043738e-01	0.297	0	0
Attenuation phase	R-HSA-3371568	4.978533e-01	0.303	0	0
Neutrophil degranulation	R-HSA-6798695	3.884043e-01	0.411	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	4.949582e-01	0.305	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	5.049900e-01	0.297	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	5.264723e-01	0.279	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	5.515033e-01	0.258	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	5.515033e-01	0.258	0	0
Peptide chain elongation	R-HSA-156902	5.008950e-01	0.300	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.481262e-01	0.261	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	5.393434e-01	0.268	0	0
Signaling by ERBB2	R-HSA-1227986	3.062099e-01	0.514	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	1.522875e-01	0.817	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	3.006547e-01	0.522	0	0
Regulation of necroptotic cell death	R-HSA-5675482	1.943169e-01	0.711	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	5.378872e-01	0.269	0	0
Specification of the neural plate border	R-HSA-9834899	3.277653e-01	0.484	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.506392e-01	0.822	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	3.406167e-01	0.468	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	5.043738e-01	0.297	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	1.478943e-01	0.830	0	0
Formation of definitive endoderm	R-HSA-9823730	3.547313e-01	0.450	0	0
ESR-mediated signaling	R-HSA-8939211	1.187897e-01	0.925	0	0
Intraflagellar transport	R-HSA-5620924	2.373713e-01	0.625	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.755515e-01	0.756	0	0
EGFR downregulation	R-HSA-182971	2.889484e-01	0.539	0	0
Eukaryotic Translation Initiation	R-HSA-72613	3.074647e-01	0.512	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.740446e-01	0.759	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	2.507548e-01	0.601	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	2.507548e-01	0.601	0	0
Protein folding	R-HSA-391251	3.476278e-01	0.459	0	0
mRNA Editing	R-HSA-75072	1.772319e-01	0.751	0	0
Cap-dependent Translation Initiation	R-HSA-72737	3.074647e-01	0.512	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	5.294532e-01	0.276	0	0
DAP12 signaling	R-HSA-2424491	4.359290e-01	0.361	0	0
Signaling by EGFR	R-HSA-177929	3.659093e-01	0.437	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	2.507548e-01	0.601	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	1.483615e-01	0.829	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	3.031862e-01	0.518	0	0
DNA Double Strand Break Response	R-HSA-5693606	1.256366e-01	0.901	0	0
p75NTR regulates axonogenesis	R-HSA-193697	4.233857e-01	0.373	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	3.743566e-01	0.427	0	0
Chromosome Maintenance	R-HSA-73886	5.580994e-01	0.253	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	4.632722e-01	0.334	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.302775e-01	0.885	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.240999e-01	0.906	0	0
Processive synthesis on the lagging strand	R-HSA-69183	4.004641e-01	0.397	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.656009e-01	0.437	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	2.076870e-01	0.683	0	0
Telomere Maintenance	R-HSA-157579	5.370256e-01	0.270	0	0
Resolution of D-Loop Structures	R-HSA-5693537	2.109503e-01	0.676	0	0
Co-stimulation by CD28	R-HSA-389356	1.437422e-01	0.842	0	0
Chaperonin-mediated protein folding	R-HSA-390466	3.729753e-01	0.428	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.772319e-01	0.751	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	1.511696e-01	0.821	0	0
MAP2K and MAPK activation	R-HSA-5674135	1.420082e-01	0.848	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	3.816430e-01	0.418	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.943169e-01	0.711	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	4.004641e-01	0.397	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	4.636176e-01	0.334	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	4.636176e-01	0.334	0	0
Regulation of the apoptosome activity	R-HSA-9627069	4.636176e-01	0.334	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	5.388358e-01	0.269	0	0
Metalloprotease DUBs	R-HSA-5689901	5.371058e-01	0.270	0	0
PI3K Cascade	R-HSA-109704	5.476159e-01	0.262	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	4.966982e-01	0.304	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	2.519606e-01	0.599	0	0
TCR signaling	R-HSA-202403	2.241369e-01	0.649	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.659093e-01	0.437	0	0
Germ layer formation at gastrulation	R-HSA-9754189	1.662131e-01	0.779	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.482207e-01	0.605	0	0
S Phase	R-HSA-69242	2.100016e-01	0.678	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.782337e-01	0.749	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.938967e-01	0.712	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.704154e-01	0.431	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	1.772319e-01	0.751	0	0
Regulation of CDH11 function	R-HSA-9762292	2.074780e-01	0.683	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.226653e-01	0.652	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.386611e-01	0.470	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.657187e-01	0.781	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	2.743613e-01	0.562	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.550969e-01	0.809	0	0
Formation of apoptosome	R-HSA-111458	4.636176e-01	0.334	0	0
PI3K/AKT activation	R-HSA-198203	4.636176e-01	0.334	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	3.269600e-01	0.486	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	3.406167e-01	0.468	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	3.180144e-01	0.498	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.144188e-01	0.942	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	3.725086e-01	0.429	0	0
Mitochondrial protein import	R-HSA-1268020	4.666211e-01	0.331	0	0
Homology Directed Repair	R-HSA-5693538	1.246407e-01	0.904	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.662131e-01	0.779	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.280867e-01	0.642	0	0
Eukaryotic Translation Elongation	R-HSA-156842	4.556356e-01	0.341	0	0
Epigenetic regulation of gene expression	R-HSA-212165	5.389764e-01	0.268	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	4.590443e-01	0.338	0	0
Cyclin D associated events in G1	R-HSA-69231	1.802224e-01	0.744	0	0
G1 Phase	R-HSA-69236	1.802224e-01	0.744	0	0
Generation of second messenger molecules	R-HSA-202433	2.099767e-01	0.678	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.045819e-01	0.689	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.635047e-01	0.786	0	0
Dopamine receptors	R-HSA-390651	1.635047e-01	0.786	0	0
VLDLR internalisation and degradation	R-HSA-8866427	3.031862e-01	0.518	0	0
Adrenoceptors	R-HSA-390696	3.816430e-01	0.418	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.816430e-01	0.418	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.099767e-01	0.678	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	3.277653e-01	0.484	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	3.718790e-01	0.430	0	0
Apoptotic factor-mediated response	R-HSA-111471	5.230291e-01	0.281	0	0
TGFBR3 expression	R-HSA-9839394	5.124145e-01	0.290	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.332536e-01	0.875	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	4.628262e-01	0.335	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.936507e-01	0.405	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.134424e-01	0.384	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.918966e-01	0.717	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	3.263792e-01	0.486	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	3.263792e-01	0.486	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	2.817309e-01	0.550	0	0
Signaling by FGFR in disease	R-HSA-1226099	5.258228e-01	0.279	0	0
Ovarian tumor domain proteases	R-HSA-5689896	1.657187e-01	0.781	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	3.656009e-01	0.437	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	3.771587e-01	0.423	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	3.554689e-01	0.449	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	3.554689e-01	0.449	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	4.818796e-01	0.317	0	0
Mitotic Prophase	R-HSA-68875	2.676077e-01	0.573	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.636241e-01	0.786	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	3.370840e-01	0.472	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	4.163293e-01	0.381	0	0
Intra-Golgi traffic	R-HSA-6811438	5.378872e-01	0.269	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.389547e-01	0.358	0	0
Sema4D in semaphorin signaling	R-HSA-400685	5.124145e-01	0.290	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.636995e-01	0.786	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	3.186951e-01	0.497	0	0
DNA Replication Pre-Initiation	R-HSA-69002	3.870103e-01	0.412	0	0
Signaling by WNT in cancer	R-HSA-4791275	4.818796e-01	0.317	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.347670e-01	0.629	0	0
Semaphorin interactions	R-HSA-373755	2.412521e-01	0.618	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.243015e-01	0.489	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.505565e-01	0.601	0	0
HDL assembly	R-HSA-8963896	1.739724e-01	0.760	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	1.144188e-01	0.942	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	1.144188e-01	0.942	0	0
Ca2+ activated K+ channels	R-HSA-1296052	3.386611e-01	0.470	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	2.102765e-01	0.677	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	3.816430e-01	0.418	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.943169e-01	0.711	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	4.126004e-01	0.384	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	4.160606e-01	0.381	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.388358e-01	0.269	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.124145e-01	0.290	0	0
Assembly of the pre-replicative complex	R-HSA-68867	2.644366e-01	0.578	0	0
Mitophagy	R-HSA-5205647	5.481262e-01	0.261	0	0
Potassium Channels	R-HSA-1296071	3.120426e-01	0.506	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	5.343223e-01	0.272	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	2.109503e-01	0.676	0	0
Diseases of Immune System	R-HSA-5260271	4.978533e-01	0.303	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	4.978533e-01	0.303	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	3.052937e-01	0.515	0	0
GPVI-mediated activation cascade	R-HSA-114604	4.147668e-01	0.382	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	5.388336e-01	0.269	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	5.371058e-01	0.270	0	0
Prolonged ERK activation events	R-HSA-169893	4.321863e-01	0.364	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.052937e-01	0.515	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	4.399892e-01	0.357	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	5.343223e-01	0.272	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	4.891724e-01	0.311	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	2.636695e-01	0.579	0	0
Regulation of CDH1 Function	R-HSA-9764561	2.613543e-01	0.583	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.218482e-01	0.492	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	4.399892e-01	0.357	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	4.399892e-01	0.357	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	5.124145e-01	0.290	0	0
Mitochondrial biogenesis	R-HSA-1592230	2.377759e-01	0.624	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.180320e-01	0.286	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	1.635047e-01	0.786	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	1.943169e-01	0.711	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	2.501215e-01	0.602	0	0
GPER1 signaling	R-HSA-9634597	2.373713e-01	0.625	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	4.004641e-01	0.397	0	0
Nuclear RNA decay	R-HSA-9930044	3.303949e-01	0.481	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	4.636176e-01	0.334	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	2.363420e-01	0.626	1	1
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	4.923314e-01	0.308	0	0
Signaling by SCF-KIT	R-HSA-1433557	4.158645e-01	0.381	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	5.271368e-01	0.278	0	0
DNA Replication	R-HSA-69306	4.925530e-01	0.308	0	0
Mismatch Repair	R-HSA-5358508	3.009272e-01	0.522	0	0
Vesicle-mediated transport	R-HSA-5653656	1.356308e-01	0.868	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	1.741673e-01	0.759	0	0
Integration of energy metabolism	R-HSA-163685	1.680608e-01	0.775	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.718790e-01	0.430	0	0
Activation of BH3-only proteins	R-HSA-114452	2.686471e-01	0.571	0	0
Glycogen metabolism	R-HSA-8982491	4.978533e-01	0.303	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	5.371058e-01	0.270	0	0
Metabolism of RNA	R-HSA-8953854	3.573571e-01	0.447	0	0
Neurofascin interactions	R-HSA-447043	2.948058e-01	0.530	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	1.337175e-01	0.874	0	0
ERK/MAPK targets	R-HSA-198753	2.067541e-01	0.685	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	5.388358e-01	0.269	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	5.043738e-01	0.297	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	4.764804e-01	0.322	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.392400e-01	0.268	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	2.797716e-01	0.553	0	0
Signaling by Hedgehog	R-HSA-5358351	1.312861e-01	0.882	0	0
Heme signaling	R-HSA-9707616	1.445030e-01	0.840	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	3.386611e-01	0.470	0	0
HIV Life Cycle	R-HSA-162587	5.348343e-01	0.272	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	4.935895e-01	0.307	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	3.659093e-01	0.437	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.351013e-01	0.361	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.383389e-01	0.471	0	0
Adaptive Immune System	R-HSA-1280218	5.280228e-01	0.277	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	2.309325e-01	0.637	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	4.773914e-01	0.321	0	0
RNA Polymerase II Transcription	R-HSA-73857	5.226046e-01	0.282	1	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.392400e-01	0.268	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	1.635047e-01	0.786	0	0
Manipulation of host energy metabolism	R-HSA-9636667	3.030798e-01	0.518	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.030798e-01	0.518	0	0
Regulation of PTEN localization	R-HSA-8948747	1.212195e-01	0.916	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	2.065295e-01	0.685	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.772319e-01	0.751	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	1.772319e-01	0.751	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	2.505565e-01	0.601	0	0
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	3.821199e-01	0.418	0	0
Inflammasomes	R-HSA-622312	1.202490e-01	0.920	0	0
DARPP-32 events	R-HSA-180024	1.337175e-01	0.874	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	2.226653e-01	0.652	0	0
MET interacts with TNS proteins	R-HSA-8875513	4.521998e-01	0.345	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	3.816430e-01	0.418	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.009272e-01	0.522	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	3.009272e-01	0.522	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.280867e-01	0.642	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.653011e-01	0.782	0	0
Alanine metabolism	R-HSA-8964540	5.143349e-01	0.289	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	3.547313e-01	0.450	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	3.816904e-01	0.418	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.636176e-01	0.334	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	3.094254e-01	0.509	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	3.386227e-01	0.470	0	0
Disorders of Developmental Biology	R-HSA-9675151	4.632722e-01	0.334	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	4.632722e-01	0.334	0	0
Bicarbonate transporters	R-HSA-425381	5.021446e-01	0.299	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	5.021446e-01	0.299	0	0
Interleukin-1 family signaling	R-HSA-446652	2.432986e-01	0.614	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	4.935895e-01	0.307	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.737820e-01	0.427	0	0
Signaling by AMER1 mutants	R-HSA-4839748	5.388358e-01	0.269	0	0
Signaling by AXIN mutants	R-HSA-4839735	5.388358e-01	0.269	0	0
Smooth Muscle Contraction	R-HSA-445355	4.521087e-01	0.345	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	5.481262e-01	0.261	0	0
Generic Transcription Pathway	R-HSA-212436	4.901355e-01	0.310	1	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.172758e-01	0.931	0	0
Cellular responses to stress	R-HSA-2262752	3.034729e-01	0.518	1	0
HDMs demethylate histones	R-HSA-3214842	3.186951e-01	0.497	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	3.420924e-01	0.466	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	4.978533e-01	0.303	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	5.388358e-01	0.269	0	0
Cellular responses to stimuli	R-HSA-8953897	1.635650e-01	0.786	1	0
Pexophagy	R-HSA-9664873	4.636176e-01	0.334	0	0
Signaling by ERBB4	R-HSA-1236394	4.004983e-01	0.397	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.614273e-01	0.583	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.317008e-01	0.635	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.772319e-01	0.751	0	0
Protein methylation	R-HSA-8876725	1.978600e-01	0.704	0	0
The NLRP3 inflammasome	R-HSA-844456	1.662131e-01	0.779	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	4.233857e-01	0.373	0	0
Cell junction organization	R-HSA-446728	1.701981e-01	0.769	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.180320e-01	0.286	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.084204e-01	0.681	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.487210e-01	0.604	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.373713e-01	0.625	0	0
Glycolysis	R-HSA-70171	1.295794e-01	0.887	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	2.279878e-01	0.642	0	0
Cell-cell junction organization	R-HSA-421270	4.269970e-01	0.370	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	3.816430e-01	0.418	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	4.636176e-01	0.334	0	0
Signal attenuation	R-HSA-74749	4.636176e-01	0.334	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.598226e-01	0.796	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	4.085182e-01	0.389	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	4.632722e-01	0.334	0	0
Adherens junctions interactions	R-HSA-418990	3.534161e-01	0.452	0	0
FLT3 signaling in disease	R-HSA-9682385	4.147668e-01	0.382	0	0
Cell-Cell communication	R-HSA-1500931	1.319441e-01	0.880	0	0
Regulation of insulin secretion	R-HSA-422356	1.723938e-01	0.763	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	4.180593e-01	0.379	0	0
MAP kinase activation	R-HSA-450294	4.499206e-01	0.347	0	0
NGF-stimulated transcription	R-HSA-9031628	5.110146e-01	0.292	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.251887e-01	0.902	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	3.386611e-01	0.470	0	0
CHL1 interactions	R-HSA-447041	3.386611e-01	0.470	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	2.743613e-01	0.562	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	3.816430e-01	0.418	0	0
RAB geranylgeranylation	R-HSA-8873719	1.251887e-01	0.902	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	5.143349e-01	0.289	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.150622e-01	0.939	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	3.006547e-01	0.522	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.719726e-01	0.565	0	0
Nephrin family interactions	R-HSA-373753	3.547313e-01	0.450	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	3.554689e-01	0.449	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.772319e-01	0.751	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.552942e-01	0.809	0	0
Stimuli-sensing channels	R-HSA-2672351	2.050104e-01	0.688	0	0
Platelet calcium homeostasis	R-HSA-418360	4.126004e-01	0.384	0	0
RUNX2 regulates bone development	R-HSA-8941326	4.147668e-01	0.382	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.342414e-01	0.362	0	0
Cardiogenesis	R-HSA-9733709	5.043738e-01	0.297	0	0
Plasma lipoprotein assembly	R-HSA-8963898	2.955023e-01	0.529	0	0
Signaling by ALK in cancer	R-HSA-9700206	2.719726e-01	0.565	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.607479e-01	0.584	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	2.889484e-01	0.539	0	0
Aquaporin-mediated transport	R-HSA-445717	2.150207e-01	0.668	0	0
Ion channel transport	R-HSA-983712	4.497069e-01	0.347	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	4.346928e-01	0.362	0	0
Gap junction trafficking	R-HSA-190828	1.802224e-01	0.744	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	4.935895e-01	0.307	0	0
Signaling by NTRKs	R-HSA-166520	2.100016e-01	0.678	0	0
Breakdown of the nuclear lamina	R-HSA-352238	3.030798e-01	0.518	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.505565e-01	0.601	0	0
DSCAM interactions	R-HSA-376172	3.821199e-01	0.418	0	0
Tandem pore domain potassium channels	R-HSA-1296346	2.074780e-01	0.683	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.521998e-01	0.345	0	0
OAS antiviral response	R-HSA-8983711	3.031862e-01	0.518	0	0
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	5.143349e-01	0.289	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	4.632722e-01	0.334	0	0
Synthesis of PI	R-HSA-1483226	5.021446e-01	0.299	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	4.935895e-01	0.307	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	3.503944e-01	0.455	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	5.371058e-01	0.270	0	0
Base Excision Repair	R-HSA-73884	3.091379e-01	0.510	0	0
Glucose metabolism	R-HSA-70326	2.377759e-01	0.624	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	2.256647e-01	0.647	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	5.410223e-01	0.267	0	0
Cell-extracellular matrix interactions	R-HSA-446353	1.978600e-01	0.704	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	2.726112e-01	0.564	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	4.359290e-01	0.361	0	0
PECAM1 interactions	R-HSA-210990	2.387609e-01	0.622	0	0
Histamine receptors	R-HSA-390650	4.521998e-01	0.345	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.456768e-01	0.610	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.636176e-01	0.334	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	3.799008e-01	0.420	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	4.935895e-01	0.307	0	0
Diseases of DNA repair	R-HSA-9675135	3.269600e-01	0.486	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.826794e-01	0.417	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	3.514019e-01	0.454	0	0
Sodium/Proton exchangers	R-HSA-425986	1.483615e-01	0.829	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.772319e-01	0.751	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	2.505565e-01	0.601	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.386611e-01	0.470	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	3.386611e-01	0.470	0	0
Interleukin-18 signaling	R-HSA-9012546	3.816430e-01	0.418	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	2.188906e-01	0.660	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	3.984759e-01	0.400	0	0
MITF-M-dependent gene expression	R-HSA-9856651	4.604418e-01	0.337	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	3.006547e-01	0.522	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.918966e-01	0.717	0	0
Regulation of beta-cell development	R-HSA-186712	2.910365e-01	0.536	0	0
Interleukin-7 signaling	R-HSA-1266695	5.124145e-01	0.290	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.067541e-01	0.685	0	0
Specification of primordial germ cells	R-HSA-9827857	2.743613e-01	0.562	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	4.351013e-01	0.361	0	0
Interleukin-1 processing	R-HSA-448706	4.233857e-01	0.373	0	0
PKR-mediated signaling	R-HSA-9833482	1.817425e-01	0.741	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	5.388358e-01	0.269	0	0
Signaling by Interleukins	R-HSA-449147	2.495378e-01	0.603	0	0
Gap junction assembly	R-HSA-190861	3.725086e-01	0.429	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.762320e-01	0.754	0	0
Interleukin-2 signaling	R-HSA-9020558	5.021446e-01	0.299	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	1.542557e-01	0.812	0	0
Depyrimidination	R-HSA-73928	1.542557e-01	0.812	0	0
Maturation of nucleoprotein	R-HSA-9694631	5.515033e-01	0.258	0	0
Interleukin-12 signaling	R-HSA-9020591	3.154663e-01	0.501	0	0
Signaling by Leptin	R-HSA-2586552	4.636176e-01	0.334	0	0
Interleukin-12 family signaling	R-HSA-447115	4.867204e-01	0.313	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	5.583684e-01	0.253	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.611497e-01	0.251	0	0
Regulated Necrosis	R-HSA-5218859	5.638534e-01	0.249	0	0
DNA Repair	R-HSA-73894	5.641131e-01	0.249	0	0
Signalling to ERKs	R-HSA-187687	5.692925e-01	0.245	0	0
Oncogene Induced Senescence	R-HSA-2559585	5.692925e-01	0.245	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	5.694255e-01	0.245	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	5.694255e-01	0.245	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.694255e-01	0.245	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.694255e-01	0.245	0	0
Activation of AKT2	R-HSA-165158	5.694255e-01	0.245	0	0
PTK6 Activates STAT3	R-HSA-8849474	5.694255e-01	0.245	0	0
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.694255e-01	0.245	0	0
Suppression of autophagy	R-HSA-9636569	5.694255e-01	0.245	0	0
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	5.694255e-01	0.245	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	5.694255e-01	0.245	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	5.698289e-01	0.244	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	5.698289e-01	0.244	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	5.736121e-01	0.241	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	5.736121e-01	0.241	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.736121e-01	0.241	0	0
Signaling by LTK	R-HSA-9842663	5.736121e-01	0.241	0	0
Pervasive developmental disorders	R-HSA-9005895	5.736121e-01	0.241	0	0
Disorders of Nervous System Development	R-HSA-9697154	5.736121e-01	0.241	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.736121e-01	0.241	0	0
Interleukin-15 signaling	R-HSA-8983432	5.736121e-01	0.241	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.757495e-01	0.240	0	0
Signaling by FGFR4	R-HSA-5654743	5.764853e-01	0.239	0	0
HIV Infection	R-HSA-162906	5.785013e-01	0.238	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	5.789439e-01	0.237	0	0
Co-inhibition by CTLA4	R-HSA-389513	5.789439e-01	0.237	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	5.789439e-01	0.237	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.830029e-01	0.234	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	5.830029e-01	0.234	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	5.844966e-01	0.233	0	0
Developmental Biology	R-HSA-1266738	5.886185e-01	0.230	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	5.890061e-01	0.230	0	0
Triglyceride catabolism	R-HSA-163560	5.899342e-01	0.229	0	0
Regulation of TP53 Degradation	R-HSA-6804757	5.899342e-01	0.229	0	0
Interleukin-17 signaling	R-HSA-448424	5.945994e-01	0.226	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	5.951666e-01	0.225	0	0
DAP12 interactions	R-HSA-2172127	5.951666e-01	0.225	0	0
Developmental Cell Lineages	R-HSA-9734767	5.961774e-01	0.225	0	0
Amino acids regulate mTORC1	R-HSA-9639288	6.001782e-01	0.222	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	6.053001e-01	0.218	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	6.053001e-01	0.218	0	0
Lagging Strand Synthesis	R-HSA-69186	6.053001e-01	0.218	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.053001e-01	0.218	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	6.053001e-01	0.218	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	6.064358e-01	0.217	0	0
Acetylcholine binding and downstream events	R-HSA-181431	6.064358e-01	0.217	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	6.064358e-01	0.217	0	0
FGFR4 ligand binding and activation	R-HSA-190322	6.064358e-01	0.217	0	0
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	6.064358e-01	0.217	0	0
Adenylate cyclase activating pathway	R-HSA-170660	6.064358e-01	0.217	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	6.064358e-01	0.217	0	0
Chylomicron remodeling	R-HSA-8963901	6.064358e-01	0.217	0	0
FGFR1c ligand binding and activation	R-HSA-190373	6.064358e-01	0.217	0	0
Processing of SMDT1	R-HSA-8949664	6.064358e-01	0.217	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	6.064358e-01	0.217	0	0
Frs2-mediated activation	R-HSA-170968	6.064358e-01	0.217	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	6.064358e-01	0.217	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	6.064358e-01	0.217	0	0
Maturation of nucleoprotein	R-HSA-9683610	6.064358e-01	0.217	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	6.064358e-01	0.217	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	6.071059e-01	0.217	0	0
mRNA Capping	R-HSA-72086	6.071059e-01	0.217	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	6.071059e-01	0.217	0	0
Regulation of mitotic cell cycle	R-HSA-453276	6.095767e-01	0.215	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.095767e-01	0.215	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	6.100194e-01	0.215	0	0
NCAM1 interactions	R-HSA-419037	6.100194e-01	0.215	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.182698e-01	0.209	0	0
Cam-PDE 1 activation	R-HSA-111957	6.182698e-01	0.209	0	0
PKB-mediated events	R-HSA-109703	6.182698e-01	0.209	0	0
PDE3B signalling	R-HSA-165160	6.182698e-01	0.209	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.182698e-01	0.209	0	0
Signaling by RNF43 mutants	R-HSA-5340588	6.182698e-01	0.209	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.182698e-01	0.209	0	0
Terminal pathway of complement	R-HSA-166665	6.182698e-01	0.209	0	0
Signaling by MST1	R-HSA-8852405	6.182698e-01	0.209	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.182698e-01	0.209	0	0
Ceramide signalling	R-HSA-193681	6.182698e-01	0.209	0	0
Formation of the Editosome	R-HSA-75094	6.182698e-01	0.209	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.182698e-01	0.209	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	6.182698e-01	0.209	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.182698e-01	0.209	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.182698e-01	0.209	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.182698e-01	0.209	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.182698e-01	0.209	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.206249e-01	0.207	0	0
Amyloid fiber formation	R-HSA-977225	6.278815e-01	0.202	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	6.295219e-01	0.201	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	6.301430e-01	0.201	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	6.301430e-01	0.201	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.305368e-01	0.200	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.305368e-01	0.200	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	6.305368e-01	0.200	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	6.305368e-01	0.200	0	0
Signaling by TGFBR3	R-HSA-9839373	6.311674e-01	0.200	0	0
IGF1R signaling cascade	R-HSA-2428924	6.359360e-01	0.197	0	0
Ion transport by P-type ATPases	R-HSA-936837	6.359360e-01	0.197	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	6.373023e-01	0.196	0	0
Retrograde neurotrophin signalling	R-HSA-177504	6.373023e-01	0.196	0	0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77348	6.373023e-01	0.196	0	0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77310	6.373023e-01	0.196	0	0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77350	6.373023e-01	0.196	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	6.373023e-01	0.196	0	0
Glycerophospholipid catabolism	R-HSA-6814848	6.373023e-01	0.196	0	0
Physiological factors	R-HSA-5578768	6.373023e-01	0.196	0	0
Signal regulatory protein family interactions	R-HSA-391160	6.373023e-01	0.196	0	0
SARS-CoV-1 Infection	R-HSA-9678108	6.388633e-01	0.195	0	0
Downstream TCR signaling	R-HSA-202424	6.443901e-01	0.191	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	6.484201e-01	0.188	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.484201e-01	0.188	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	6.484201e-01	0.188	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	6.484469e-01	0.188	0	0
Signaling by FGFR1	R-HSA-5654736	6.493915e-01	0.187	0	0
Downstream signal transduction	R-HSA-186763	6.499917e-01	0.187	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.508965e-01	0.186	0	0
Signaling by TGFB family members	R-HSA-9006936	6.509456e-01	0.186	0	0
Signaling by NOTCH4	R-HSA-9013694	6.527573e-01	0.185	0	0
Notch-HLH transcription pathway	R-HSA-350054	6.546325e-01	0.184	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.546325e-01	0.184	0	0
LDL clearance	R-HSA-8964038	6.546325e-01	0.184	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	6.546325e-01	0.184	0	0
Cytoprotection by HMOX1	R-HSA-9707564	6.548492e-01	0.184	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	6.570927e-01	0.182	0	0
Signaling by FGFR	R-HSA-190236	6.594348e-01	0.181	0	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	6.615758e-01	0.179	0	0
STAT5 Activation	R-HSA-9645135	6.615758e-01	0.179	0	0
Erythropoietin activates STAT5	R-HSA-9027283	6.615758e-01	0.179	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.615758e-01	0.179	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.615758e-01	0.179	0	0
Abacavir transmembrane transport	R-HSA-2161517	6.615758e-01	0.179	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.615758e-01	0.179	0	0
Lipid particle organization	R-HSA-8964572	6.615758e-01	0.179	0	0
IRS-mediated signalling	R-HSA-112399	6.649731e-01	0.177	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	6.649731e-01	0.177	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	6.662333e-01	0.176	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.662333e-01	0.176	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	6.662333e-01	0.176	0	0
Translesion synthesis by REV1	R-HSA-110312	6.662333e-01	0.176	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.662333e-01	0.176	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	6.662333e-01	0.176	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	6.662333e-01	0.176	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	6.662333e-01	0.176	0	0
p38MAPK events	R-HSA-171007	6.662333e-01	0.176	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.662333e-01	0.176	0	0
ISG15 antiviral mechanism	R-HSA-1169408	6.665285e-01	0.176	0	0
Protein ubiquitination	R-HSA-8852135	6.665285e-01	0.176	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	6.666972e-01	0.176	0	0
Interleukin-2 family signaling	R-HSA-451927	6.666972e-01	0.176	0	0
Signaling by WNT	R-HSA-195721	6.669201e-01	0.176	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.679116e-01	0.175	0	0
DNA strand elongation	R-HSA-69190	6.702270e-01	0.174	0	0
G0 and Early G1	R-HSA-1538133	6.702270e-01	0.174	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.756235e-01	0.170	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	6.775779e-01	0.169	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	6.775779e-01	0.169	0	0
Syndecan interactions	R-HSA-3000170	6.775779e-01	0.169	0	0
Signaling by NOTCH1	R-HSA-1980143	6.799728e-01	0.168	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.799728e-01	0.168	0	0
DNA Damage Bypass	R-HSA-73893	6.814884e-01	0.167	0	0
Degradation of CDH1	R-HSA-9766229	6.814884e-01	0.167	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.814884e-01	0.167	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.814884e-01	0.167	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.817208e-01	0.166	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	6.837476e-01	0.165	0	0
Signaling by NOTCH	R-HSA-157118	6.847477e-01	0.164	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	6.896413e-01	0.161	0	0
Activation of ATR in response to replication stress	R-HSA-176187	6.896413e-01	0.161	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.896413e-01	0.161	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	6.896413e-01	0.161	0	0
Differentiation of T cells	R-HSA-9945266	6.932705e-01	0.159	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.932705e-01	0.159	0	0
Translesion synthesis by POLI	R-HSA-5656121	6.932705e-01	0.159	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	6.932705e-01	0.159	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.932705e-01	0.159	0	0
Regulation of BACH1 activity	R-HSA-9708530	6.932705e-01	0.159	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.932705e-01	0.159	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	6.932705e-01	0.159	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.932705e-01	0.159	0	0
Negative regulation of FLT3	R-HSA-9706369	6.932705e-01	0.159	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.932705e-01	0.159	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	6.932705e-01	0.159	0	0
Selenocysteine synthesis	R-HSA-2408557	6.944166e-01	0.158	0	0
snRNP Assembly	R-HSA-191859	6.948329e-01	0.158	0	0
Metabolism of non-coding RNA	R-HSA-194441	6.948329e-01	0.158	0	0
Cellular response to chemical stress	R-HSA-9711123	6.991871e-01	0.155	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	6.993738e-01	0.155	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	6.993738e-01	0.155	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	6.993738e-01	0.155	0	0
Complex III assembly	R-HSA-9865881	6.993738e-01	0.155	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	6.999710e-01	0.155	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.999710e-01	0.155	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.999710e-01	0.155	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.999710e-01	0.155	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.999710e-01	0.155	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.999710e-01	0.155	0	0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	6.999710e-01	0.155	0	0
Disinhibition of SNARE formation	R-HSA-114516	6.999710e-01	0.155	0	0
Recycling of eIF2:GDP	R-HSA-72731	6.999710e-01	0.155	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	6.999710e-01	0.155	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.999710e-01	0.155	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.999710e-01	0.155	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.999710e-01	0.155	0	0
VLDL clearance	R-HSA-8964046	6.999710e-01	0.155	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	6.999710e-01	0.155	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	6.999710e-01	0.155	0	0
Glycoprotein hormones	R-HSA-209822	6.999710e-01	0.155	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.999710e-01	0.155	0	0
Maturation of replicase proteins	R-HSA-9694301	6.999710e-01	0.155	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.013427e-01	0.154	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.013427e-01	0.154	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	7.013427e-01	0.154	0	0
Toll-like Receptor Cascades	R-HSA-168898	7.028193e-01	0.153	0	0
Co-inhibition by PD-1	R-HSA-389948	7.047607e-01	0.152	0	0
Mitochondrial protein degradation	R-HSA-9837999	7.052711e-01	0.152	0	0
Regulation of endogenous retroelements	R-HSA-9842860	7.055820e-01	0.151	0	0
Phospholipid metabolism	R-HSA-1483257	7.057934e-01	0.151	0	0
RNA Polymerase I Transcription	R-HSA-73864	7.058526e-01	0.151	0	0
G1/S Transition	R-HSA-69206	7.079576e-01	0.150	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	7.082300e-01	0.150	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	7.090956e-01	0.149	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	7.124412e-01	0.147	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	7.129870e-01	0.147	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	7.166295e-01	0.145	0	0
Activation of GABAB receptors	R-HSA-991365	7.176982e-01	0.144	0	0
GABA B receptor activation	R-HSA-977444	7.176982e-01	0.144	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	7.176982e-01	0.144	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.184713e-01	0.144	0	0
Translesion synthesis by POLK	R-HSA-5655862	7.184713e-01	0.144	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	7.184713e-01	0.144	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	7.184713e-01	0.144	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	7.184713e-01	0.144	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	7.184713e-01	0.144	0	0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77346	7.184713e-01	0.144	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	7.184713e-01	0.144	0	0
Synthesis of PG	R-HSA-1483148	7.184713e-01	0.144	0	0
Tight junction interactions	R-HSA-420029	7.200302e-01	0.143	0	0
G protein gated Potassium channels	R-HSA-1296059	7.200302e-01	0.143	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.200302e-01	0.143	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	7.200302e-01	0.143	0	0
Acyl chain remodelling of PS	R-HSA-1482801	7.200302e-01	0.143	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.200962e-01	0.143	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.229067e-01	0.141	0	0
Eukaryotic Translation Termination	R-HSA-72764	7.277052e-01	0.138	0	0
Signaling by FGFR2	R-HSA-5654738	7.303526e-01	0.136	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.334060e-01	0.135	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.340123e-01	0.134	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.340123e-01	0.134	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	7.340123e-01	0.134	0	0
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	7.340123e-01	0.134	0	0
Regulation by c-FLIP	R-HSA-3371378	7.340123e-01	0.134	0	0
Co-stimulation by ICOS	R-HSA-9927354	7.340123e-01	0.134	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	7.340123e-01	0.134	0	0
Dimerization of procaspase-8	R-HSA-69416	7.340123e-01	0.134	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.340123e-01	0.134	0	0
Nucleotide salvage defects	R-HSA-9734207	7.340123e-01	0.134	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	7.373941e-01	0.132	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	7.395644e-01	0.131	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.395644e-01	0.131	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.395644e-01	0.131	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	7.399952e-01	0.131	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	7.419043e-01	0.130	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	7.419043e-01	0.130	0	0
Nucleotide Excision Repair	R-HSA-5696398	7.476633e-01	0.126	0	0
Amine ligand-binding receptors	R-HSA-375280	7.484680e-01	0.126	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	7.491639e-01	0.125	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.491639e-01	0.125	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	7.546171e-01	0.122	0	0
Switching of origins to a post-replicative state	R-HSA-69052	7.569248e-01	0.121	0	0
Platelet homeostasis	R-HSA-418346	7.575268e-01	0.121	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	7.580000e-01	0.120	0	0
G1/S-Specific Transcription	R-HSA-69205	7.590732e-01	0.120	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	7.590732e-01	0.120	0	0
Insulin receptor signalling cascade	R-HSA-74751	7.616093e-01	0.118	0	0
Signaling by FGFR3	R-HSA-5654741	7.628890e-01	0.118	0	0
Fanconi Anemia Pathway	R-HSA-6783310	7.628890e-01	0.118	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.628890e-01	0.118	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	7.636461e-01	0.117	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	7.636461e-01	0.117	0	0
GAB1 signalosome	R-HSA-180292	7.636461e-01	0.117	0	0
FGFR1 ligand binding and activation	R-HSA-190242	7.636461e-01	0.117	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	7.636461e-01	0.117	0	0
Nephron development	R-HSA-9831926	7.636461e-01	0.117	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	7.636461e-01	0.117	0	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	7.641929e-01	0.117	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.641929e-01	0.117	0	0
CASP8 activity is inhibited	R-HSA-5218900	7.641929e-01	0.117	0	0
ALK mutants bind TKIs	R-HSA-9700645	7.641929e-01	0.117	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	7.641929e-01	0.117	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.641929e-01	0.117	0	0
Degradation of GABA	R-HSA-916853	7.641929e-01	0.117	0	0
Unwinding of DNA	R-HSA-176974	7.641929e-01	0.117	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.641929e-01	0.117	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	7.641929e-01	0.117	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.641929e-01	0.117	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.641929e-01	0.117	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	7.641929e-01	0.117	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.671249e-01	0.115	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	7.744111e-01	0.111	0	0
Gene expression (Transcription)	R-HSA-74160	7.749898e-01	0.111	1	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	7.753657e-01	0.110	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.766760e-01	0.110	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.766760e-01	0.110	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.766760e-01	0.110	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.766760e-01	0.110	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	7.778691e-01	0.109	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.794911e-01	0.108	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	7.805088e-01	0.108	0	0
Leishmania infection	R-HSA-9658195	7.831267e-01	0.106	0	0
Parasitic Infection Pathways	R-HSA-9824443	7.831267e-01	0.106	0	0
Regulation of signaling by CBL	R-HSA-912631	7.837787e-01	0.106	0	0
Other interleukin signaling	R-HSA-449836	7.837787e-01	0.106	0	0
Crosslinking of collagen fibrils	R-HSA-2243919	7.837787e-01	0.106	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	7.837787e-01	0.106	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	7.837787e-01	0.106	0	0
Cellular response to starvation	R-HSA-9711097	7.858895e-01	0.105	0	0
Interleukin-1 signaling	R-HSA-9020702	7.881184e-01	0.103	0	0
MET promotes cell motility	R-HSA-8875878	7.889684e-01	0.103	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.898385e-01	0.102	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.898385e-01	0.102	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.909507e-01	0.102	0	0
DNA replication initiation	R-HSA-68952	7.909507e-01	0.102	0	0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	7.909507e-01	0.102	0	0
Binding and entry of HIV virion	R-HSA-173107	7.909507e-01	0.102	0	0
Formation of intermediate mesoderm	R-HSA-9761174	7.909507e-01	0.102	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	7.909507e-01	0.102	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.909507e-01	0.102	0	0
Maturation of spike protein	R-HSA-9683686	7.909507e-01	0.102	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	7.909507e-01	0.102	0	0
Sperm Motility And Taxes	R-HSA-1300642	7.909507e-01	0.102	0	0
Peptide hormone biosynthesis	R-HSA-209952	7.909507e-01	0.102	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	7.909507e-01	0.102	0	0
Signaling by Erythropoietin	R-HSA-9006335	7.916943e-01	0.101	0	0
Potential therapeutics for SARS	R-HSA-9679191	7.941109e-01	0.100	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	7.982608e-01	0.098	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	8.023874e-01	0.096	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	8.023874e-01	0.096	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	8.023874e-01	0.096	0	0
Signaling by NODAL	R-HSA-1181150	8.023874e-01	0.096	0	0
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.023874e-01	0.096	0	0
Protein hydroxylation	R-HSA-9629569	8.023874e-01	0.096	0	0
Metal ion SLC transporters	R-HSA-425410	8.023877e-01	0.096	0	0
Plasma lipoprotein clearance	R-HSA-8964043	8.027638e-01	0.095	0	0
Signaling by ALK	R-HSA-201556	8.027638e-01	0.095	0	0
Viral mRNA Translation	R-HSA-192823	8.059519e-01	0.094	0	0
Activation of the pre-replicative complex	R-HSA-68962	8.070219e-01	0.093	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.070219e-01	0.093	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.070219e-01	0.093	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.070219e-01	0.093	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.086205e-01	0.092	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	8.144429e-01	0.089	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	8.144429e-01	0.089	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	8.146735e-01	0.089	0	0
FGFR2b ligand binding and activation	R-HSA-190377	8.146735e-01	0.089	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.146735e-01	0.089	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.146735e-01	0.089	0	0
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	8.146735e-01	0.089	0	0
Chylomicron assembly	R-HSA-8963888	8.146735e-01	0.089	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.146735e-01	0.089	0	0
Transport of RCbl within the body	R-HSA-9758890	8.146735e-01	0.089	0	0
Prostanoid ligand receptors	R-HSA-391908	8.146735e-01	0.089	0	0
Dissolution of Fibrin Clot	R-HSA-75205	8.146735e-01	0.089	0	0
Extension of Telomeres	R-HSA-180786	8.150797e-01	0.089	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.150797e-01	0.089	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.158181e-01	0.088	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	8.184209e-01	0.087	0	0
Signalling to RAS	R-HSA-167044	8.195586e-01	0.086	0	0
Basigin interactions	R-HSA-210991	8.195586e-01	0.086	0	0
G alpha (s) signalling events	R-HSA-418555	8.197355e-01	0.086	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.199376e-01	0.086	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	8.213869e-01	0.085	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.213869e-01	0.085	0	0
RSV-host interactions	R-HSA-9833110	8.226535e-01	0.085	0	0
GABA receptor activation	R-HSA-977443	8.256030e-01	0.083	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	8.256030e-01	0.083	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	8.256030e-01	0.083	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	8.256030e-01	0.083	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	8.256030e-01	0.083	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	8.256030e-01	0.083	0	0
COPII-mediated vesicle transport	R-HSA-204005	8.269141e-01	0.083	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	8.353790e-01	0.078	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	8.353790e-01	0.078	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	8.353790e-01	0.078	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	8.353790e-01	0.078	0	0
Signaling by PDGFR in disease	R-HSA-9671555	8.353790e-01	0.078	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	8.357055e-01	0.078	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	8.357055e-01	0.078	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.357055e-01	0.078	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.357055e-01	0.078	0	0
ERKs are inactivated	R-HSA-202670	8.357055e-01	0.078	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	8.357055e-01	0.078	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	8.357055e-01	0.078	0	0
Sodium/Calcium exchangers	R-HSA-425561	8.357055e-01	0.078	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.357055e-01	0.078	0	0
Hedgehog 'on' state	R-HSA-5632684	8.362929e-01	0.078	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.397951e-01	0.076	0	0
Neurotransmitter release cycle	R-HSA-112310	8.401144e-01	0.076	0	0
Adipogenesis	R-HSA-9843745	8.421980e-01	0.075	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.452135e-01	0.073	0	0
Synthesis of DNA	R-HSA-69239	8.456381e-01	0.073	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.459403e-01	0.073	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.467306e-01	0.072	0	0
G-protein beta:gamma signalling	R-HSA-397795	8.473906e-01	0.072	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.499338e-01	0.071	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	8.499338e-01	0.071	0	0
Signaling by KIT in disease	R-HSA-9669938	8.499338e-01	0.071	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.499338e-01	0.071	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	8.499338e-01	0.071	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	8.499338e-01	0.071	0	0
Ca2+ pathway	R-HSA-4086398	8.538341e-01	0.069	0	0
Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77285	8.543518e-01	0.068	0	0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	8.543518e-01	0.068	0	0
GRB2 events in EGFR signaling	R-HSA-179812	8.543518e-01	0.068	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.543518e-01	0.068	0	0
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	8.543518e-01	0.068	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.543518e-01	0.068	0	0
Repression of WNT target genes	R-HSA-4641265	8.543518e-01	0.068	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.543518e-01	0.068	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.543518e-01	0.068	0	0
Estrogen biosynthesis	R-HSA-193144	8.543518e-01	0.068	0	0
Acyl chain remodelling of PC	R-HSA-1482788	8.591125e-01	0.066	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.591125e-01	0.066	0	0
Heme degradation	R-HSA-189483	8.591125e-01	0.066	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	8.633066e-01	0.064	0	0
Interleukin receptor SHC signaling	R-HSA-912526	8.633066e-01	0.064	0	0
Growth hormone receptor signaling	R-HSA-982772	8.633066e-01	0.064	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.656167e-01	0.063	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.656167e-01	0.063	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.672071e-01	0.062	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.698200e-01	0.061	0	0
Dual Incision in GG-NER	R-HSA-5696400	8.700369e-01	0.060	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	8.700369e-01	0.060	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.700369e-01	0.060	0	0
FGFR2c ligand binding and activation	R-HSA-190375	8.708828e-01	0.060	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.708828e-01	0.060	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	8.708828e-01	0.060	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	8.708828e-01	0.060	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.708828e-01	0.060	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.708828e-01	0.060	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	8.708828e-01	0.060	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	8.708828e-01	0.060	0	0
Diseases of nucleotide metabolism	R-HSA-9735804	8.708828e-01	0.060	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.708828e-01	0.060	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.708828e-01	0.060	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	8.711268e-01	0.060	0	0
Signaling by NOTCH3	R-HSA-9012852	8.743006e-01	0.058	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	8.755780e-01	0.058	0	0
TNFs bind their physiological receptors	R-HSA-5669034	8.755780e-01	0.058	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.825032e-01	0.054	0	0
Interferon Signaling	R-HSA-913531	8.830330e-01	0.054	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.830330e-01	0.054	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.833698e-01	0.054	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	8.833698e-01	0.054	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	8.855384e-01	0.053	0	0
CRMPs in Sema3A signaling	R-HSA-399956	8.855384e-01	0.053	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.855384e-01	0.053	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.855384e-01	0.053	0	0
FGFR3c ligand binding and activation	R-HSA-190372	8.855384e-01	0.053	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.855384e-01	0.053	0	0
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	8.855384e-01	0.053	0	0
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	8.855384e-01	0.053	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	8.855384e-01	0.053	0	0
Malate-aspartate shuttle	R-HSA-9856872	8.855384e-01	0.053	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.855384e-01	0.053	0	0
Acyl chain remodeling of CL	R-HSA-1482798	8.855384e-01	0.053	0	0
Zinc transporters	R-HSA-435354	8.855384e-01	0.053	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.855384e-01	0.053	0	0
Formation of the nephric duct	R-HSA-9830364	8.868258e-01	0.052	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.884798e-01	0.051	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.896602e-01	0.051	0	0
HSF1 activation	R-HSA-3371511	8.896602e-01	0.051	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.896602e-01	0.051	0	0
RNA Polymerase III Transcription	R-HSA-74158	8.896602e-01	0.051	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	8.896602e-01	0.051	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.964970e-01	0.047	0	0
MET activates PTK2 signaling	R-HSA-8874081	8.971241e-01	0.047	0	0
Myogenesis	R-HSA-525793	8.971241e-01	0.047	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	8.971241e-01	0.047	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.971241e-01	0.047	0	0
Dual incision in TC-NER	R-HSA-6782135	8.975405e-01	0.047	0	0
Voltage gated Potassium channels	R-HSA-1296072	8.984405e-01	0.047	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.985313e-01	0.046	0	0
Erythropoietin activates RAS	R-HSA-9027284	8.985313e-01	0.046	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.985313e-01	0.046	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	8.985313e-01	0.046	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	8.985313e-01	0.046	0	0
Protein lipoylation	R-HSA-9857492	8.985313e-01	0.046	0	0
Signaling by Activin	R-HSA-1502540	8.985313e-01	0.046	0	0
FGFR3 ligand binding and activation	R-HSA-190239	8.985313e-01	0.046	0	0
Beta oxidation of butanoyl-CoA to acetyl-CoA	R-HSA-77352	8.985313e-01	0.046	0	0
Dopamine clearance from the synaptic cleft	R-HSA-379401	8.985313e-01	0.046	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	8.985313e-01	0.046	0	0
Other semaphorin interactions	R-HSA-416700	8.985313e-01	0.046	0	0
Formation of the anterior neural plate	R-HSA-9823739	8.985313e-01	0.046	0	0
HCMV Early Events	R-HSA-9609690	9.006299e-01	0.045	0	0
Host Interactions of HIV factors	R-HSA-162909	9.013961e-01	0.045	0	0
Hemostasis	R-HSA-109582	9.035662e-01	0.044	0	0
Immune System	R-HSA-168256	9.036877e-01	0.044	0	0
Gluconeogenesis	R-HSA-70263	9.040024e-01	0.044	0	0
Triglyceride metabolism	R-HSA-8979227	9.044131e-01	0.044	0	0
Gene Silencing by RNA	R-HSA-211000	9.058063e-01	0.043	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	9.065436e-01	0.043	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	9.065436e-01	0.043	0	0
Signaling by BMP	R-HSA-201451	9.065436e-01	0.043	0	0
Insulin processing	R-HSA-264876	9.065436e-01	0.043	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.065862e-01	0.043	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	9.065862e-01	0.043	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.066045e-01	0.043	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.068427e-01	0.042	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.100500e-01	0.041	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	9.100500e-01	0.041	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	9.100500e-01	0.041	0	0
Killing mechanisms	R-HSA-9664420	9.100500e-01	0.041	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	9.100500e-01	0.041	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.100500e-01	0.041	0	0
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	9.100500e-01	0.041	0	0
Atorvastatin ADME	R-HSA-9754706	9.100500e-01	0.041	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	9.108801e-01	0.041	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.108801e-01	0.041	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.141354e-01	0.039	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.151511e-01	0.039	0	0
Pyroptosis	R-HSA-5620971	9.151511e-01	0.039	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.151511e-01	0.039	0	0
Pyrimidine salvage	R-HSA-73614	9.151511e-01	0.039	0	0
IRE1alpha activates chaperones	R-HSA-381070	9.177285e-01	0.037	0	0
Platelet degranulation	R-HSA-114608	9.193962e-01	0.036	0	0
Glycine degradation	R-HSA-6783984	9.202616e-01	0.036	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.202616e-01	0.036	0	0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	R-HSA-77288	9.202616e-01	0.036	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	9.202616e-01	0.036	0	0
Passive transport by Aquaporins	R-HSA-432047	9.202616e-01	0.036	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	9.202616e-01	0.036	0	0
Coenzyme A biosynthesis	R-HSA-196783	9.202616e-01	0.036	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.211250e-01	0.036	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	9.211250e-01	0.036	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.211250e-01	0.036	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.211250e-01	0.036	0	0
Signaling by PDGF	R-HSA-186797	9.226711e-01	0.035	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.230093e-01	0.035	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.270628e-01	0.033	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.275904e-01	0.033	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.293146e-01	0.032	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.293146e-01	0.032	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.293146e-01	0.032	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.293146e-01	0.032	0	0
Glycogen storage diseases	R-HSA-3229121	9.293146e-01	0.032	0	0
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	9.293146e-01	0.032	0	0
Sulfide oxidation to sulfate	R-HSA-1614517	9.293146e-01	0.032	0	0
Catecholamine biosynthesis	R-HSA-209905	9.293146e-01	0.032	0	0
Choline catabolism	R-HSA-6798163	9.293146e-01	0.032	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.293146e-01	0.032	0	0
Orc1 removal from chromatin	R-HSA-68949	9.294138e-01	0.032	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.294138e-01	0.032	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	9.301776e-01	0.031	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	9.301776e-01	0.031	0	0
Neurotransmitter clearance	R-HSA-112311	9.301776e-01	0.031	0	0
Collagen formation	R-HSA-1474290	9.313755e-01	0.031	0	0
Translation of Structural Proteins	R-HSA-9683701	9.335656e-01	0.030	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.347353e-01	0.029	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	9.347353e-01	0.029	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	9.367111e-01	0.028	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	9.367111e-01	0.028	0	0
Budding and maturation of HIV virion	R-HSA-162588	9.367111e-01	0.028	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.367111e-01	0.028	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	9.373401e-01	0.028	0	0
Activated point mutants of FGFR2	R-HSA-2033519	9.373401e-01	0.028	0	0
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	9.373401e-01	0.028	0	0
Platelet sensitization by LDL	R-HSA-432142	9.373401e-01	0.028	0	0
UCH proteinases	R-HSA-5689603	9.374195e-01	0.028	0	0
Gastrulation	R-HSA-9758941	9.374622e-01	0.028	0	0
Parasite infection	R-HSA-9664407	9.375719e-01	0.028	0	0
Leishmania phagocytosis	R-HSA-9664417	9.375719e-01	0.028	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.375719e-01	0.028	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.407211e-01	0.027	0	0
Influenza Infection	R-HSA-168255	9.410137e-01	0.026	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.421788e-01	0.026	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.429457e-01	0.026	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.434899e-01	0.025	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.441736e-01	0.025	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.443002e-01	0.025	0	0
G alpha (z) signalling events	R-HSA-418597	9.443002e-01	0.025	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	9.444549e-01	0.025	0	0
Pyrimidine biosynthesis	R-HSA-500753	9.444549e-01	0.025	0	0
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	9.444549e-01	0.025	0	0
STING mediated induction of host immune responses	R-HSA-1834941	9.444549e-01	0.025	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.444549e-01	0.025	0	0
HDL remodeling	R-HSA-8964058	9.444549e-01	0.025	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.444549e-01	0.025	0	0
PCP/CE pathway	R-HSA-4086400	9.455063e-01	0.024	0	0
Interleukin-10 signaling	R-HSA-6783783	9.455063e-01	0.024	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	9.480773e-01	0.023	0	0
Protein localization	R-HSA-9609507	9.489654e-01	0.023	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.507622e-01	0.022	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.507622e-01	0.022	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.507622e-01	0.022	0	0
Glycogen synthesis	R-HSA-3322077	9.507622e-01	0.022	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.507622e-01	0.022	0	0
Signal transduction by L1	R-HSA-445144	9.507622e-01	0.022	0	0
Negative regulation of MET activity	R-HSA-6807004	9.507622e-01	0.022	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	9.507622e-01	0.022	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	9.530029e-01	0.021	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	9.531897e-01	0.021	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	9.531897e-01	0.021	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.531897e-01	0.021	0	0
PPARA activates gene expression	R-HSA-1989781	9.539945e-01	0.020	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	9.539945e-01	0.020	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	9.552050e-01	0.020	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.562626e-01	0.019	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.563536e-01	0.019	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	9.563536e-01	0.019	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	9.563536e-01	0.019	0	0
FGFR2 ligand binding and activation	R-HSA-190241	9.563536e-01	0.019	0	0
G-protein activation	R-HSA-202040	9.563536e-01	0.019	0	0
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.563536e-01	0.019	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.563536e-01	0.019	0	0
Phenylalanine metabolism	R-HSA-8964208	9.563536e-01	0.019	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	9.563536e-01	0.019	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.563536e-01	0.019	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.563536e-01	0.019	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	9.571333e-01	0.019	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	9.571692e-01	0.019	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.571692e-01	0.019	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.574797e-01	0.019	0	0
eNOS activation	R-HSA-203615	9.574797e-01	0.019	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.574797e-01	0.019	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.574797e-01	0.019	0	0
Nuclear import of Rev protein	R-HSA-180746	9.574797e-01	0.019	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	9.574797e-01	0.019	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.585849e-01	0.018	0	0
Ribosome-associated quality control	R-HSA-9948299	9.599413e-01	0.018	0	0
Signaling by Insulin receptor	R-HSA-74752	9.611777e-01	0.017	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.613104e-01	0.017	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.613104e-01	0.017	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	9.613104e-01	0.017	0	0
Assembly Of The HIV Virion	R-HSA-175474	9.613104e-01	0.017	0	0
Glutathione synthesis and recycling	R-HSA-174403	9.613104e-01	0.017	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.615461e-01	0.017	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	9.615461e-01	0.017	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.615461e-01	0.017	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	9.636766e-01	0.016	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.641948e-01	0.016	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	9.657045e-01	0.015	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.657045e-01	0.015	0	0
Biosynthesis of D-series resolvins	R-HSA-9018676	9.657045e-01	0.015	0	0
Ethanol oxidation	R-HSA-71384	9.657045e-01	0.015	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.657045e-01	0.015	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.657045e-01	0.015	0	0
Cellular hexose transport	R-HSA-189200	9.657045e-01	0.015	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.658123e-01	0.015	0	0
Innate Immune System	R-HSA-168249	9.662600e-01	0.015	0	0
Circadian clock	R-HSA-9909396	9.672771e-01	0.014	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.672861e-01	0.014	0	0
Degradation of DVL	R-HSA-4641258	9.685871e-01	0.014	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	9.685871e-01	0.014	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.685871e-01	0.014	0	0
Lysine catabolism	R-HSA-71064	9.685871e-01	0.014	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.695997e-01	0.013	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.695997e-01	0.013	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.695997e-01	0.013	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	9.695997e-01	0.013	0	0
Biosynthesis of maresins	R-HSA-9018682	9.695997e-01	0.013	0	0
rRNA processing	R-HSA-72312	9.698515e-01	0.013	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	9.701240e-01	0.013	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.710675e-01	0.013	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.710675e-01	0.013	0	0
Elastic fibre formation	R-HSA-1566948	9.716243e-01	0.013	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.720522e-01	0.012	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.727278e-01	0.012	0	0
The phototransduction cascade	R-HSA-2514856	9.727278e-01	0.012	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.730528e-01	0.012	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.730528e-01	0.012	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.730528e-01	0.012	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.730528e-01	0.012	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.743771e-01	0.011	0	0
Pentose phosphate pathway	R-HSA-71336	9.743771e-01	0.011	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	9.743771e-01	0.011	0	0
Stabilization of p53	R-HSA-69541	9.743771e-01	0.011	0	0
Translation of Structural Proteins	R-HSA-9694635	9.750765e-01	0.011	0	0
Cellular response to hypoxia	R-HSA-1234174	9.755445e-01	0.011	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.761138e-01	0.010	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.761138e-01	0.010	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.761138e-01	0.010	0	0
Alpha-oxidation of phytanate	R-HSA-389599	9.761138e-01	0.010	0	0
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.761138e-01	0.010	0	0
Hyaluronan degradation	R-HSA-2160916	9.761138e-01	0.010	0	0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	9.761138e-01	0.010	0	0
Fertilization	R-HSA-1187000	9.761138e-01	0.010	0	0
Laminin interactions	R-HSA-3000157	9.761138e-01	0.010	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	9.761138e-01	0.010	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	9.761138e-01	0.010	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.768708e-01	0.010	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	9.768708e-01	0.010	0	0
ER-Phagosome pathway	R-HSA-1236974	9.771718e-01	0.010	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.773033e-01	0.010	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	9.788272e-01	0.009	0	0
Urea cycle	R-HSA-70635	9.788272e-01	0.009	0	0
Abacavir ADME	R-HSA-2161522	9.788272e-01	0.009	0	0
Sphingolipid catabolism	R-HSA-9845614	9.788272e-01	0.009	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.788272e-01	0.009	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.788272e-01	0.009	0	0
Suppression of phagosomal maturation	R-HSA-9637687	9.788272e-01	0.009	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.791288e-01	0.009	0	0
Maturation of spike protein	R-HSA-9694548	9.791288e-01	0.009	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	9.791288e-01	0.009	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.791288e-01	0.009	0	0
Interferon gamma signaling	R-HSA-877300	9.792687e-01	0.009	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.793698e-01	0.009	0	0
Kidney development	R-HSA-9830369	9.793704e-01	0.009	0	0
HCMV Infection	R-HSA-9609646	9.793852e-01	0.009	0	0
Viral Infection Pathways	R-HSA-9824446	9.794213e-01	0.009	0	0
PTEN Regulation	R-HSA-6807070	9.798733e-01	0.009	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	9.798733e-01	0.009	0	0
Signaling by MET	R-HSA-6806834	9.803750e-01	0.009	0	0
Paracetamol ADME	R-HSA-9753281	9.811419e-01	0.008	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.812326e-01	0.008	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.812326e-01	0.008	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	9.812326e-01	0.008	0	0
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.812326e-01	0.008	0	0
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	9.812326e-01	0.008	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.812326e-01	0.008	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.812326e-01	0.008	0	0
Maturation of hRSV A proteins	R-HSA-9828806	9.812326e-01	0.008	0	0
Inositol phosphate metabolism	R-HSA-1483249	9.815160e-01	0.008	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.828204e-01	0.008	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.830213e-01	0.007	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.831516e-01	0.007	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.833648e-01	0.007	0	0
Prednisone ADME	R-HSA-9757110	9.833648e-01	0.007	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.833648e-01	0.007	0	0
Dectin-2 family	R-HSA-5621480	9.843553e-01	0.007	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.845830e-01	0.007	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.846033e-01	0.007	0	0
Formation of the cornified envelope	R-HSA-6809371	9.846127e-01	0.007	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.846932e-01	0.007	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	9.852549e-01	0.006	0	0
Thyroxine biosynthesis	R-HSA-209968	9.852549e-01	0.006	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.852549e-01	0.006	0	0
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.852549e-01	0.006	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.862045e-01	0.006	0	0
Proteasome assembly	R-HSA-9907900	9.862045e-01	0.006	0	0
RMTs methylate histone arginines	R-HSA-3214858	9.862045e-01	0.006	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.862045e-01	0.006	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.862183e-01	0.006	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.869303e-01	0.006	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.870071e-01	0.006	0	0
Peroxisomal protein import	R-HSA-9033241	9.870402e-01	0.006	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.870402e-01	0.006	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.875701e-01	0.005	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.875701e-01	0.005	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.875701e-01	0.005	0	0
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	9.875701e-01	0.005	0	0
Somitogenesis	R-HSA-9824272	9.875701e-01	0.005	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.879623e-01	0.005	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.882108e-01	0.005	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.884154e-01	0.005	0	0
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	9.884154e-01	0.005	0	0
Cargo concentration in the ER	R-HSA-5694530	9.884154e-01	0.005	0	0
Aspartate and asparagine metabolism	R-HSA-8963693	9.884154e-01	0.005	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.887683e-01	0.005	0	0
GPCR downstream signalling	R-HSA-388396	9.889932e-01	0.005	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	9.892792e-01	0.005	0	0
Nucleotide salvage	R-HSA-8956321	9.892792e-01	0.005	0	0
Collagen degradation	R-HSA-1442490	9.892792e-01	0.005	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.893767e-01	0.005	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.897179e-01	0.004	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.897319e-01	0.004	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	9.908988e-01	0.004	0	0
Recycling of bile acids and salts	R-HSA-159418	9.908988e-01	0.004	0	0
SARS-CoV Infections	R-HSA-9679506	9.917121e-01	0.004	0	0
Vpu mediated degradation of CD4	R-HSA-180534	9.919332e-01	0.004	0	0
Glutamate and glutamine metabolism	R-HSA-8964539	9.919332e-01	0.004	0	0
Miscellaneous transport and binding events	R-HSA-5223345	9.919332e-01	0.004	0	0
ABC transporter disorders	R-HSA-5619084	9.921278e-01	0.003	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.925577e-01	0.003	0	0
Azathioprine ADME	R-HSA-9748787	9.926480e-01	0.003	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.928031e-01	0.003	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.928501e-01	0.003	0	0
Hyaluronan metabolism	R-HSA-2142845	9.928501e-01	0.003	0	0
Signaling by NOTCH2	R-HSA-1980145	9.928501e-01	0.003	0	0
RA biosynthesis pathway	R-HSA-5365859	9.928501e-01	0.003	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.928501e-01	0.003	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.928501e-01	0.003	0	0
Signal amplification	R-HSA-392518	9.928501e-01	0.003	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.933858e-01	0.003	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.936628e-01	0.003	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.936628e-01	0.003	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.936628e-01	0.003	0	0
Regulation of Apoptosis	R-HSA-169911	9.936628e-01	0.003	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.936628e-01	0.003	0	0
PERK regulates gene expression	R-HSA-381042	9.936628e-01	0.003	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.936628e-01	0.003	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.939776e-01	0.003	0	0
Nicotinate metabolism	R-HSA-196807	9.939776e-01	0.003	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.940510e-01	0.003	0	0
HCMV Late Events	R-HSA-9610379	9.941605e-01	0.003	0	0
Glycosphingolipid transport	R-HSA-9845576	9.943831e-01	0.002	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.945353e-01	0.002	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.946792e-01	0.002	0	0
SARS-CoV-2 Infection	R-HSA-9694516	9.947139e-01	0.002	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.950217e-01	0.002	0	0
Degradation of AXIN	R-HSA-4641257	9.950217e-01	0.002	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.950217e-01	0.002	0	0
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.950217e-01	0.002	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.950217e-01	0.002	0	0
Collagen chain trimerization	R-HSA-8948216	9.950217e-01	0.002	0	0
Metabolism of folate and pterines	R-HSA-196757	9.950217e-01	0.002	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.952463e-01	0.002	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.955041e-01	0.002	0	0
Purine salvage	R-HSA-74217	9.955876e-01	0.002	0	0
Metabolism of cofactors	R-HSA-8978934	9.959238e-01	0.002	0	0
Metabolism of porphyrins	R-HSA-189445	9.959238e-01	0.002	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.960893e-01	0.002	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.960893e-01	0.002	0	0
RAS processing	R-HSA-9648002	9.960893e-01	0.002	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.961150e-01	0.002	0	0
G alpha (i) signalling events	R-HSA-418594	9.964274e-01	0.002	0	0
Synthesis of PA	R-HSA-1483166	9.965094e-01	0.002	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.965269e-01	0.002	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.965339e-01	0.002	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.965339e-01	0.002	0	0
Tryptophan catabolism	R-HSA-71240	9.965339e-01	0.002	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.966410e-01	0.001	0	0
G alpha (q) signalling events	R-HSA-416476	9.967702e-01	0.001	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.969280e-01	0.001	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.972774e-01	0.001	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.972774e-01	0.001	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.975870e-01	0.001	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.975870e-01	0.001	0	0
Pyrimidine catabolism	R-HSA-73621	9.978614e-01	0.001	0	0
Cholesterol biosynthesis	R-HSA-191273	9.979615e-01	0.001	0	0
tRNA processing in the nucleus	R-HSA-6784531	9.979618e-01	0.001	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	9.983202e-01	0.001	0	0
Post-translational protein modification	R-HSA-597592	9.984277e-01	0.001	0	0
Neddylation	R-HSA-8951664	9.985024e-01	0.001	0	0
Synthesis of PC	R-HSA-1483191	9.986806e-01	0.001	0	0
Metabolism of steroid hormones	R-HSA-196071	9.988149e-01	0.001	0	0
Signaling by GPCR	R-HSA-372790	9.988420e-01	0.001	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.989372e-01	0.000	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.989637e-01	0.000	0	0
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.989637e-01	0.000	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.990816e-01	0.000	0	0
Complex IV assembly	R-HSA-9864848	9.991861e-01	0.000	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.991861e-01	0.000	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.992341e-01	0.000	0	0
Retinoid metabolism and transport	R-HSA-975634	9.992341e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.993136e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.993320e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.994244e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.995259e-01	0.000	0	0
SLC transporter disorders	R-HSA-5619102	9.995414e-01	0.000	0	0
Digestion	R-HSA-8935690	9.995551e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.996828e-01	0.000	0	0
tRNA Aminoacylation	R-HSA-379724	9.997257e-01	0.000	0	0
Glutathione conjugation	R-HSA-156590	9.997257e-01	0.000	0	0
Metabolism of polyamines	R-HSA-351202	9.997257e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.997362e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.997453e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.997603e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.997603e-01	0.000	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.997833e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.998053e-01	0.000	0	0
Complex I biogenesis	R-HSA-6799198	9.998091e-01	0.000	0	0
Digestion and absorption	R-HSA-8963743	9.998091e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.998169e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.998245e-01	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.998501e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998823e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.998918e-01	0.000	0	0
Glycosphingolipid catabolism	R-HSA-9840310	9.999181e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999275e-01	0.000	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.999357e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999430e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.999430e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999447e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999465e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999553e-01	0.000	0	0
Iron uptake and transport	R-HSA-917937	9.999553e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.999562e-01	0.000	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.999609e-01	0.000	0	0
tRNA processing	R-HSA-72306	9.999685e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.999689e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999724e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999784e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.999785e-01	0.000	0	0
Infectious disease	R-HSA-5663205	9.999799e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999822e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999849e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999856e-01	0.000	0	0
Translation	R-HSA-72766	9.999866e-01	0.000	0	0
Disease	R-HSA-1643685	9.999875e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.999895e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999905e-01	0.000	0	0
Pyruvate metabolism	R-HSA-70268	9.999907e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999941e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999949e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999952e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999953e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999965e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.999969e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999983e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999984e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999984e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999993e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999994e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	9.999997e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999999e-01	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	9.999999e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999999e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cellular response to heat stress	R-HSA-3371556	1.110223e-16	15.955	0	0
Cell Cycle	R-HSA-1640170	2.220446e-16	15.654	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.998401e-15	14.699	0	0
Cell Cycle, Mitotic	R-HSA-69278	9.103829e-15	14.041	0	0
Attenuation phase	R-HSA-3371568	3.708145e-14	13.431	0	0
HSF1-dependent transactivation	R-HSA-3371571	4.329870e-14	13.364	0	0
HSF1 activation	R-HSA-3371511	1.421419e-12	11.847	0	0
M Phase	R-HSA-68886	1.748046e-12	11.757	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.076029e-12	11.216	0	0
Apoptotic execution phase	R-HSA-75153	3.048251e-11	10.516	0	0
Cell Cycle Checkpoints	R-HSA-69620	4.987388e-11	10.302	0	0
Cellular responses to stress	R-HSA-2262752	1.153700e-10	9.938	1	0
Cellular responses to stimuli	R-HSA-8953897	2.070693e-10	9.684	1	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	6.002698e-10	9.222	0	0
Separation of Sister Chromatids	R-HSA-2467813	1.160060e-09	8.936	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.266773e-09	8.897	0	0
DNA Double Strand Break Response	R-HSA-5693606	1.523504e-09	8.817	0	0
Mitotic Anaphase	R-HSA-68882	1.692100e-09	8.772	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.954214e-09	8.709	0	0
Apoptosis	R-HSA-109581	6.729202e-09	8.172	0	0
Metabolism of RNA	R-HSA-8953854	2.103469e-08	7.677	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.482602e-08	7.458	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.994950e-08	7.398	0	0
Mitotic Prometaphase	R-HSA-68877	4.239688e-08	7.373	0	0
G2/M Checkpoints	R-HSA-69481	5.247915e-08	7.280	0	0
Cell-Cell communication	R-HSA-1500931	6.550219e-08	7.184	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	6.760225e-08	7.170	0	0
Signaling by ALK in cancer	R-HSA-9700206	6.760225e-08	7.170	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.082936e-07	6.965	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.383418e-07	6.859	0	0
G2/M DNA damage checkpoint	R-HSA-69473	1.365081e-07	6.865	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.478804e-07	6.830	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.439798e-07	6.613	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	2.460936e-07	6.609	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.798242e-07	6.553	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.798242e-07	6.553	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.958047e-07	6.529	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.824416e-07	6.417	0	0
Programmed Cell Death	R-HSA-5357801	5.527453e-07	6.257	0	0
Cell junction organization	R-HSA-446728	5.895229e-07	6.229	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	6.227943e-07	6.206	0	0
DNA Replication Pre-Initiation	R-HSA-69002	8.637722e-07	6.064	0	0
Mitotic Prophase	R-HSA-68875	9.091786e-07	6.041	0	0
Assembly of the pre-replicative complex	R-HSA-68867	9.425354e-07	6.026	0	0
Cellular Senescence	R-HSA-2559583	1.683900e-06	5.774	1	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.740756e-06	5.759	0	0
Homology Directed Repair	R-HSA-5693538	1.822965e-06	5.739	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.954698e-06	5.709	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.987633e-06	5.702	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.102753e-06	5.677	0	0
Meiotic synapsis	R-HSA-1221632	2.221883e-06	5.653	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.317518e-06	5.635	0	0
Adherens junctions interactions	R-HSA-418990	2.457065e-06	5.610	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	2.674318e-06	5.573	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	3.486596e-06	5.458	0	0
Nucleosome assembly	R-HSA-774815	4.369215e-06	5.360	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.369215e-06	5.360	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	5.063206e-06	5.296	0	0
Estrogen-dependent gene expression	R-HSA-9018519	5.544208e-06	5.256	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	5.599393e-06	5.252	0	0
Protein ubiquitination	R-HSA-8852135	6.264953e-06	5.203	0	0
Mitotic G2-G2/M phases	R-HSA-453274	9.796161e-06	5.009	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.065308e-05	4.973	0	0
Deubiquitination	R-HSA-5688426	1.078902e-05	4.967	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.098616e-05	4.959	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.106299e-05	4.956	0	0
Membrane Trafficking	R-HSA-199991	1.169908e-05	4.932	0	0
Signal Transduction	R-HSA-162582	1.369548e-05	4.863	1	0
Cell-cell junction organization	R-HSA-421270	1.512565e-05	4.820	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	1.864073e-05	4.730	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	2.524674e-05	4.598	0	0
mRNA Splicing	R-HSA-72172	2.681530e-05	4.572	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	2.814448e-05	4.551	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	2.760146e-05	4.559	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	2.853237e-05	4.545	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.859877e-05	4.544	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.459923e-05	4.461	0	0
Striated Muscle Contraction	R-HSA-390522	3.539303e-05	4.451	0	0
G2/M Transition	R-HSA-69275	3.768201e-05	4.424	0	0
Signaling by NOTCH3	R-HSA-9012852	4.152107e-05	4.382	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.183644e-05	4.378	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.505124e-05	4.346	0	0
Ub-specific processing proteases	R-HSA-5689880	4.540758e-05	4.343	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	4.594661e-05	4.338	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	4.868025e-05	4.313	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.053123e-05	4.296	0	0
Axon guidance	R-HSA-422475	5.224287e-05	4.282	0	0
Aggrephagy	R-HSA-9646399	5.305535e-05	4.275	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.305535e-05	4.275	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	5.305535e-05	4.275	0	0
Signaling by Hippo	R-HSA-2028269	5.600252e-05	4.252	0	0
ISG15 antiviral mechanism	R-HSA-1169408	5.621511e-05	4.250	0	0
Nervous system development	R-HSA-9675108	6.032471e-05	4.220	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	6.143022e-05	4.212	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	6.213313e-05	4.207	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.213313e-05	4.207	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	7.141270e-05	4.146	1	0
Interferon Signaling	R-HSA-913531	8.016042e-05	4.096	0	0
Signaling by NOTCH	R-HSA-157118	8.881495e-05	4.052	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	9.147231e-05	4.039	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	9.605323e-05	4.017	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	9.580181e-05	4.019	0	0
Oncogenic MAPK signaling	R-HSA-6802957	9.863757e-05	4.006	0	0
Meiosis	R-HSA-1500620	9.863757e-05	4.006	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	9.579461e-05	4.019	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	9.726979e-05	4.012	1	1
Signaling by ERBB2	R-HSA-1227986	1.069442e-04	3.971	0	0
DNA Replication	R-HSA-69306	1.108162e-04	3.955	0	0
Epigenetic regulation of gene expression	R-HSA-212165	1.121552e-04	3.950	0	0
PKR-mediated signaling	R-HSA-9833482	1.247638e-04	3.904	0	0
ESR-mediated signaling	R-HSA-8939211	1.335663e-04	3.874	0	0
S Phase	R-HSA-69242	1.422712e-04	3.847	0	0
DNA methylation	R-HSA-5334118	1.504757e-04	3.823	0	0
Negative regulation of MET activity	R-HSA-6807004	1.569128e-04	3.804	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.586623e-04	3.800	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.611637e-04	3.793	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.611637e-04	3.793	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.871896e-04	3.728	0	0
Regulation of CDH1 Function	R-HSA-9764561	1.882256e-04	3.725	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.138696e-04	3.670	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.179307e-04	3.662	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.248541e-04	3.648	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	2.636312e-04	3.579	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	2.543321e-04	3.595	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.500519e-04	3.602	0	0
snRNP Assembly	R-HSA-191859	2.656853e-04	3.576	0	0
Metabolism of non-coding RNA	R-HSA-194441	2.656853e-04	3.576	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.720767e-04	3.565	0	0
PRC2 methylates histones and DNA	R-HSA-212300	2.720767e-04	3.565	0	0
Smooth Muscle Contraction	R-HSA-445355	2.777661e-04	3.556	0	0
Signaling by RAF1 mutants	R-HSA-9656223	2.833791e-04	3.548	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.872393e-04	3.542	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.147862e-04	3.502	0	0
Amplification of signal from the kinetochores	R-HSA-141424	2.973836e-04	3.527	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.973836e-04	3.527	0	0
Gene expression (Transcription)	R-HSA-74160	3.037910e-04	3.517	1	0
Autophagy	R-HSA-9612973	3.191854e-04	3.496	0	0
Packaging Of Telomere Ends	R-HSA-171306	3.528402e-04	3.452	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	3.528402e-04	3.452	0	0
mTORC1-mediated signalling	R-HSA-166208	3.805492e-04	3.420	0	0
HDACs deacetylate histones	R-HSA-3214815	3.927341e-04	3.406	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.947107e-04	3.404	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	3.947107e-04	3.404	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.089623e-04	3.388	0	0
Selective autophagy	R-HSA-9663891	4.444744e-04	3.352	0	0
Defective pyroptosis	R-HSA-9710421	4.191824e-04	3.378	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	4.333161e-04	3.363	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	4.383522e-04	3.358	0	0
Diseases of programmed cell death	R-HSA-9645723	4.444744e-04	3.352	0	0
Signaling by EGFR	R-HSA-177929	4.641743e-04	3.333	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	4.763030e-04	3.322	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	4.920438e-04	3.308	0	0
Gene Silencing by RNA	R-HSA-211000	4.923597e-04	3.308	0	0
Cell-extracellular matrix interactions	R-HSA-446353	5.000805e-04	3.301	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.000805e-04	3.301	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	5.000805e-04	3.301	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	5.083572e-04	3.294	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	5.211658e-04	3.283	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	5.718375e-04	3.243	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	6.121715e-04	3.213	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.710568e-04	3.243	0	0
Regulation of endogenous retroelements	R-HSA-9842860	5.642967e-04	3.248	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	6.121715e-04	3.213	0	0
Nuclear import of Rev protein	R-HSA-180746	6.088324e-04	3.216	0	0
Chromosome Maintenance	R-HSA-73886	5.766884e-04	3.239	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	5.705320e-04	3.244	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	6.183158e-04	3.209	0	0
RNA Polymerase I Transcription	R-HSA-73864	6.405062e-04	3.193	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	6.712970e-04	3.173	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	6.712970e-04	3.173	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.712970e-04	3.173	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	6.936621e-04	3.159	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	7.249322e-04	3.140	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	7.249322e-04	3.140	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	7.249322e-04	3.140	0	0
Signaling by RAS mutants	R-HSA-6802949	7.249322e-04	3.140	0	0
Recycling pathway of L1	R-HSA-437239	8.617135e-04	3.065	0	0
Kinesins	R-HSA-983189	8.724512e-04	3.059	0	0
EGFR downregulation	R-HSA-182971	8.918245e-04	3.050	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.053235e-03	2.977	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	9.479719e-04	3.023	0	0
Signaling by NOTCH4	R-HSA-9013694	9.407023e-04	3.027	0	0
Interleukin-12 family signaling	R-HSA-447115	9.489156e-04	3.023	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.101012e-03	2.958	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.101012e-03	2.958	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.106915e-03	2.956	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.106915e-03	2.956	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.106915e-03	2.956	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.106915e-03	2.956	0	0
Chromatin organization	R-HSA-4839726	1.125951e-03	2.948	0	0
DNA Repair	R-HSA-73894	1.203269e-03	2.920	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.224390e-03	2.912	0	0
Interleukin-12 signaling	R-HSA-9020591	1.224390e-03	2.912	0	0
Chromatin modifying enzymes	R-HSA-3247509	1.249799e-03	2.903	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.254397e-03	2.902	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.291706e-03	2.889	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.434715e-03	2.843	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.565167e-03	2.805	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.565167e-03	2.805	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	1.565167e-03	2.805	0	0
Josephin domain DUBs	R-HSA-5689877	1.565167e-03	2.805	0	0
Meiotic recombination	R-HSA-912446	1.646081e-03	2.784	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	1.598257e-03	2.796	0	0
L1CAM interactions	R-HSA-373760	1.592382e-03	2.798	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.495143e-03	2.825	0	0
MITF-M-dependent gene expression	R-HSA-9856651	1.520709e-03	2.818	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.651715e-03	2.782	0	0
Host Interactions of HIV factors	R-HSA-162909	1.656360e-03	2.781	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.729071e-03	2.762	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.729071e-03	2.762	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	1.794791e-03	2.746	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.904172e-03	2.720	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	1.915405e-03	2.718	0	0
Dual Incision in GG-NER	R-HSA-5696400	1.983012e-03	2.703	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.983012e-03	2.703	0	0
Late endosomal microautophagy	R-HSA-9615710	1.995544e-03	2.700	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	2.013589e-03	2.696	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	2.094710e-03	2.679	0	0
Regulation of signaling by CBL	R-HSA-912631	2.168355e-03	2.664	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.259128e-03	2.646	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.437340e-03	2.613	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.468610e-03	2.608	0	0
HCMV Early Events	R-HSA-9609690	2.594447e-03	2.586	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	2.437340e-03	2.613	0	0
Macroautophagy	R-HSA-1632852	2.475528e-03	2.606	0	0
Activation of BH3-only proteins	R-HSA-114452	2.437340e-03	2.613	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.281997e-03	2.642	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.332651e-03	2.632	0	0
MAP2K and MAPK activation	R-HSA-5674135	2.660319e-03	2.575	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	2.660319e-03	2.575	0	0
Muscle contraction	R-HSA-397014	2.683640e-03	2.571	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	2.709565e-03	2.567	0	0
SARS-CoV-2 Infection	R-HSA-9694516	2.747393e-03	2.561	0	0
Regulation of TP53 Degradation	R-HSA-6804757	2.840374e-03	2.547	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.845365e-03	2.546	0	0
SARS-CoV Infections	R-HSA-9679506	2.918634e-03	2.535	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.954312e-03	2.530	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.954312e-03	2.530	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	2.991411e-03	2.524	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.999927e-03	2.523	0	0
MTOR signalling	R-HSA-165159	3.120981e-03	2.506	0	0
NF-kB is activated and signals survival	R-HSA-209560	3.162721e-03	2.500	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.179275e-03	2.498	0	0
Cleavage of the damaged purine	R-HSA-110331	3.369092e-03	2.472	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.505399e-03	2.455	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.505399e-03	2.455	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	3.594033e-03	2.444	0	0
Metalloprotease DUBs	R-HSA-5689901	3.626465e-03	2.441	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.973897e-03	2.401	0	0
Depurination	R-HSA-73927	3.973897e-03	2.401	0	0
Disorders of Developmental Biology	R-HSA-9675151	4.014413e-03	2.396	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	4.046415e-03	2.393	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	4.249101e-03	2.372	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	4.249101e-03	2.372	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	4.311652e-03	2.365	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	4.311652e-03	2.365	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	5.045635e-03	2.297	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	5.004674e-03	2.301	0	0
HIV Life Cycle	R-HSA-162587	5.033057e-03	2.298	0	0
Hedgehog 'off' state	R-HSA-5610787	4.816820e-03	2.317	0	0
Switching of origins to a post-replicative state	R-HSA-69052	4.788532e-03	2.320	0	0
Signaling by WNT	R-HSA-195721	4.718806e-03	2.326	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	5.139140e-03	2.289	0	0
Vesicle-mediated transport	R-HSA-5653656	4.459476e-03	2.351	0	0
Glycolysis	R-HSA-70171	4.816820e-03	2.317	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	5.045635e-03	2.297	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.662252e-03	2.331	0	0
Signaling by Interleukins	R-HSA-449147	5.219707e-03	2.282	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	5.406637e-03	2.267	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	5.441921e-03	2.264	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	5.649000e-03	2.248	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	5.664273e-03	2.247	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	5.664273e-03	2.247	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	5.664273e-03	2.247	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	5.664273e-03	2.247	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	5.664273e-03	2.247	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	5.710827e-03	2.243	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	5.710827e-03	2.243	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	5.742470e-03	2.241	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	5.798385e-03	2.237	0	0
Signaling by NOTCH2	R-HSA-1980145	5.954693e-03	2.225	0	0
Co-inhibition by PD-1	R-HSA-389948	5.969071e-03	2.224	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	5.969071e-03	2.224	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	5.972988e-03	2.224	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	6.320940e-03	2.199	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	6.320940e-03	2.199	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.320940e-03	2.199	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	6.483780e-03	2.188	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	6.485321e-03	2.188	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	6.485321e-03	2.188	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	6.494332e-03	2.187	0	0
Reproduction	R-HSA-1474165	6.541278e-03	2.184	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.611935e-03	2.180	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	6.817972e-03	2.166	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	6.986491e-03	2.156	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	7.131899e-03	2.147	0	0
Maturation of protein E	R-HSA-9683683	7.131899e-03	2.147	0	0
Maturation of protein E	R-HSA-9694493	7.131899e-03	2.147	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	8.026000e-03	2.096	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	8.077580e-03	2.093	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	8.008532e-03	2.096	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.956762e-03	2.048	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.360905e-03	2.133	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.316407e-03	2.080	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.763918e-03	2.110	0	0
EPH-Ephrin signaling	R-HSA-2682334	8.786778e-03	2.056	0	0
Translesion Synthesis by POLH	R-HSA-110320	8.077580e-03	2.093	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.196598e-03	2.143	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	8.008532e-03	2.096	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	7.605625e-03	2.119	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	7.605625e-03	2.119	0	0
Telomere Maintenance	R-HSA-157579	7.476099e-03	2.126	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	7.584478e-03	2.120	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	7.491925e-03	2.125	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	7.491925e-03	2.125	0	0
Signaling by VEGF	R-HSA-194138	7.690838e-03	2.114	0	0
HATs acetylate histones	R-HSA-3214847	8.946723e-03	2.048	0	0
RNA Polymerase II Transcription	R-HSA-73857	7.588534e-03	2.120	1	0
Negative regulation of MAPK pathway	R-HSA-5675221	7.307582e-03	2.136	0	0
Pexophagy	R-HSA-9664873	8.026000e-03	2.096	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.956762e-03	2.048	0	0
Influenza Infection	R-HSA-168255	7.861161e-03	2.105	0	0
FLT3 signaling in disease	R-HSA-9682385	8.151494e-03	2.089	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	8.410321e-03	2.075	0	0
Depyrimidination	R-HSA-73928	8.410321e-03	2.075	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	9.366830e-03	2.028	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	9.596353e-03	2.018	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	9.596353e-03	2.018	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	9.596353e-03	2.018	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	9.596353e-03	2.018	0	0
Translesion synthesis by REV1	R-HSA-110312	9.596353e-03	2.018	0	0
p75NTR signals via NF-kB	R-HSA-193639	9.596353e-03	2.018	0	0
Spry regulation of FGF signaling	R-HSA-1295596	9.596353e-03	2.018	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	9.616479e-03	2.017	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	9.616479e-03	2.017	0	0
Sema4D in semaphorin signaling	R-HSA-400685	9.616479e-03	2.017	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.786852e-03	2.009	0	0
Synthesis of DNA	R-HSA-69239	9.829653e-03	2.007	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	9.940553e-03	2.003	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	9.940553e-03	2.003	0	0
Nephrin family interactions	R-HSA-373753	9.940553e-03	2.003	0	0
Signaling by MET	R-HSA-6806834	1.003087e-02	1.999	0	0
Post NMDA receptor activation events	R-HSA-438064	1.033316e-02	1.986	0	0
SARS-CoV-1 Infection	R-HSA-9678108	1.046162e-02	1.980	0	0
Dual incision in TC-NER	R-HSA-6782135	1.051827e-02	1.978	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.051827e-02	1.978	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.064948e-02	1.973	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.064948e-02	1.973	0	0
Amyloid fiber formation	R-HSA-977225	1.105475e-02	1.956	0	0
Signaling by TGFB family members	R-HSA-9006936	1.106989e-02	1.956	0	0
AURKA Activation by TPX2	R-HSA-8854518	1.124106e-02	1.949	0	0
HIV Infection	R-HSA-162906	1.138466e-02	1.944	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	1.145292e-02	1.941	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.145292e-02	1.941	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.192885e-02	1.923	0	0
Translesion synthesis by POLI	R-HSA-5656121	1.209107e-02	1.918	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.209107e-02	1.918	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.209859e-02	1.917	0	0
mRNA 3'-end processing	R-HSA-72187	1.221639e-02	1.913	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	1.225530e-02	1.912	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.225530e-02	1.912	0	0
Signaling by Hedgehog	R-HSA-5358351	1.274597e-02	1.895	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.297410e-02	1.887	0	0
Centrosome maturation	R-HSA-380287	1.300029e-02	1.886	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.332506e-02	1.875	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	1.353557e-02	1.869	0	0
COPI-mediated anterograde transport	R-HSA-6807878	1.365364e-02	1.865	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.365411e-02	1.865	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.535338e-02	1.814	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.535338e-02	1.814	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.535338e-02	1.814	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.535338e-02	1.814	0	0
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.535338e-02	1.814	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.535338e-02	1.814	0	0
Pervasive developmental disorders	R-HSA-9005895	1.811620e-02	1.742	0	0
Disorders of Nervous System Development	R-HSA-9697154	1.811620e-02	1.742	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.811620e-02	1.742	0	0
Translesion synthesis by POLK	R-HSA-5655862	1.500984e-02	1.824	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.500984e-02	1.824	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.838435e-02	1.736	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.457545e-02	1.836	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	1.850865e-02	1.733	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	1.850865e-02	1.733	0	0
RAF activation	R-HSA-5673000	1.638318e-02	1.786	0	0
Translation initiation complex formation	R-HSA-72649	1.537208e-02	1.813	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.800882e-02	1.745	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.800882e-02	1.745	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.635056e-02	1.786	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.784038e-02	1.749	0	0
VLDLR internalisation and degradation	R-HSA-8866427	1.811620e-02	1.742	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	1.588184e-02	1.799	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.500984e-02	1.824	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.588184e-02	1.799	0	0
Signaling by NOTCH1	R-HSA-1980143	1.431779e-02	1.844	0	0
RAF/MAP kinase cascade	R-HSA-5673001	1.770973e-02	1.752	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	1.415650e-02	1.849	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.479301e-02	1.830	0	0
Regulation of PTEN localization	R-HSA-8948747	1.507143e-02	1.822	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.413418e-02	1.850	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.811620e-02	1.742	0	0
IRAK1 recruits IKK complex	R-HSA-937039	1.811620e-02	1.742	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	1.746083e-02	1.758	0	0
p75NTR recruits signalling complexes	R-HSA-209543	1.811620e-02	1.742	0	0
tRNA processing in the nucleus	R-HSA-6784531	1.625866e-02	1.789	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.415650e-02	1.849	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.687193e-02	1.773	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.457545e-02	1.836	0	0
Regulation of mitotic cell cycle	R-HSA-453276	1.856798e-02	1.731	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.856798e-02	1.731	0	0
Oncogene Induced Senescence	R-HSA-2559585	1.879153e-02	1.726	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	1.910912e-02	1.719	0	0
TNF signaling	R-HSA-75893	1.910912e-02	1.719	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.925938e-02	1.715	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.011508e-02	1.696	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.039020e-02	1.691	0	0
MAPK family signaling cascades	R-HSA-5683057	2.051485e-02	1.688	1	0
Downregulation of ERBB4 signaling	R-HSA-1253288	2.053770e-02	1.687	0	0
Modulation by Mtb of host immune system	R-HSA-9637628	2.053770e-02	1.687	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	2.057622e-02	1.687	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.057622e-02	1.687	0	0
Ca-dependent events	R-HSA-111996	2.093893e-02	1.679	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.093893e-02	1.679	0	0
CaM pathway	R-HSA-111997	2.144668e-02	1.669	0	0
Calmodulin induced events	R-HSA-111933	2.144668e-02	1.669	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.204314e-02	1.657	0	0
Death Receptor Signaling	R-HSA-73887	2.216658e-02	1.654	0	0
Ephrin signaling	R-HSA-3928664	2.224377e-02	1.653	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.224377e-02	1.653	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.277498e-02	1.643	0	0
HCMV Infection	R-HSA-9609646	2.342815e-02	1.630	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	2.353433e-02	1.628	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.414236e-02	1.617	0	0
Neurodegenerative Diseases	R-HSA-8863678	2.414236e-02	1.617	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	2.418540e-02	1.616	0	0
Ovarian tumor domain proteases	R-HSA-5689896	2.436098e-02	1.613	0	0
Glucose metabolism	R-HSA-70326	2.439430e-02	1.613	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	2.457189e-02	1.610	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	2.466825e-02	1.608	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	2.557322e-02	1.592	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.618739e-02	1.582	0	0
Gap junction trafficking	R-HSA-190828	2.640003e-02	1.578	0	0
Base Excision Repair	R-HSA-73884	2.641381e-02	1.578	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	2.708007e-02	1.567	0	0
Viral Infection Pathways	R-HSA-9824446	2.754095e-02	1.560	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	2.774627e-02	1.557	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.814601e-02	1.551	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.814601e-02	1.551	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.823113e-02	1.549	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.858482e-02	1.544	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.858482e-02	1.544	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	2.858482e-02	1.544	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.874152e-02	1.541	0	0
Platelet degranulation	R-HSA-114608	2.885770e-02	1.540	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.889197e-02	1.539	0	0
DAG and IP3 signaling	R-HSA-1489509	2.948207e-02	1.530	0	0
Fanconi Anemia Pathway	R-HSA-6783310	2.948207e-02	1.530	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.948207e-02	1.530	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.948207e-02	1.530	0	0
Nucleotide Excision Repair	R-HSA-5696398	2.951419e-02	1.530	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.069971e-02	1.513	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	3.069971e-02	1.513	0	0
Signaling by ROBO receptors	R-HSA-376176	3.097432e-02	1.509	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	3.137241e-02	1.503	0	0
Co-inhibition by CTLA4	R-HSA-389513	3.151931e-02	1.501	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.151931e-02	1.501	0	0
Integrin signaling	R-HSA-354192	3.213446e-02	1.493	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.250026e-02	1.488	0	0
Manipulation of host energy metabolism	R-HSA-9636667	3.250591e-02	1.488	0	0
Breakdown of the nuclear lamina	R-HSA-352238	3.250591e-02	1.488	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.281048e-02	1.484	0	0
Eukaryotic Translation Elongation	R-HSA-156842	3.321335e-02	1.479	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	3.387061e-02	1.470	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	3.425778e-02	1.465	0	0
Protein methylation	R-HSA-8876725	3.425778e-02	1.465	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.989505e-02	1.399	0	0
Signaling by APC mutants	R-HSA-4839744	4.351941e-02	1.361	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.351941e-02	1.361	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.351941e-02	1.361	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.351941e-02	1.361	0	0
Phosphorylation of the APC/C	R-HSA-176412	4.113160e-02	1.386	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.300690e-02	1.366	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	3.732427e-02	1.428	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	3.732427e-02	1.428	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	4.101064e-02	1.387	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	3.477329e-02	1.459	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	4.600433e-02	1.337	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	4.320776e-02	1.364	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.320776e-02	1.364	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.320776e-02	1.364	0	0
Degradation of CDH1	R-HSA-9766229	4.435490e-02	1.353	0	0
Regulation of RAS by GAPs	R-HSA-5658442	4.874664e-02	1.312	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	4.089238e-02	1.388	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.071069e-02	1.390	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	5.148542e-02	1.288	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	3.625170e-02	1.441	0	0
Cap-dependent Translation Initiation	R-HSA-72737	3.986736e-02	1.399	0	0
Eukaryotic Translation Initiation	R-HSA-72613	3.986736e-02	1.399	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	3.883513e-02	1.411	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.473449e-02	1.459	0	0
DNA Damage Bypass	R-HSA-73893	4.435490e-02	1.353	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	4.331571e-02	1.363	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	4.331571e-02	1.363	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	4.331571e-02	1.363	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.600433e-02	1.337	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	4.300690e-02	1.366	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	3.572527e-02	1.447	0	0
PTEN Regulation	R-HSA-6807070	3.985584e-02	1.400	0	0
G1/S Transition	R-HSA-69206	4.331571e-02	1.363	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	3.477329e-02	1.459	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	3.883513e-02	1.411	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.732427e-02	1.428	0	0
Cilium Assembly	R-HSA-5617833	3.944143e-02	1.404	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	3.697815e-02	1.432	0	0
Mitophagy	R-HSA-5205647	4.101064e-02	1.387	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	3.758742e-02	1.425	0	0
Signaling by PTK6	R-HSA-8848021	3.758742e-02	1.425	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	4.113160e-02	1.386	0	0
Hedgehog 'on' state	R-HSA-5632684	3.750217e-02	1.426	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	3.883513e-02	1.411	0	0
Generic Transcription Pathway	R-HSA-212436	4.395513e-02	1.357	1	0
Regulation of NF-kappa B signaling	R-HSA-9758274	4.113160e-02	1.386	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	3.509302e-02	1.455	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	4.351941e-02	1.361	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.089238e-02	1.388	0	0
Developmental Biology	R-HSA-1266738	5.017791e-02	1.299	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.300690e-02	1.366	0	0
Semaphorin interactions	R-HSA-373755	3.758742e-02	1.425	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.732427e-02	1.428	0	0
Regulation of TP53 Activity	R-HSA-5633007	5.019055e-02	1.299	1	0
Gap junction trafficking and regulation	R-HSA-157858	4.435490e-02	1.353	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	5.148542e-02	1.288	0	0
Negative regulation of FLT3	R-HSA-9706369	4.113160e-02	1.386	0	0
Signaling by PDGFR in disease	R-HSA-9671555	4.300690e-02	1.366	0	0
Assembly Of The HIV Virion	R-HSA-175474	4.300690e-02	1.366	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	5.189357e-02	1.285	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.252103e-02	1.280	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	5.271368e-02	1.278	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	5.291545e-02	1.276	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	5.291545e-02	1.276	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	5.299141e-02	1.276	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	5.313021e-02	1.275	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.313021e-02	1.275	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	5.313021e-02	1.275	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	5.342042e-02	1.272	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	5.343695e-02	1.272	0	0
Signaling by AMER1 mutants	R-HSA-4839748	5.343695e-02	1.272	0	0
Signaling by AXIN mutants	R-HSA-4839735	5.343695e-02	1.272	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	5.343695e-02	1.272	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	5.440404e-02	1.264	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	5.440404e-02	1.264	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	5.440404e-02	1.264	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	5.440404e-02	1.264	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	5.440404e-02	1.264	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	5.440404e-02	1.264	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	5.440404e-02	1.264	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	5.440404e-02	1.264	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	5.440404e-02	1.264	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	5.440404e-02	1.264	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	5.440404e-02	1.264	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	5.440404e-02	1.264	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	5.539389e-02	1.257	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	5.590344e-02	1.253	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	5.681923e-02	1.246	0	0
Growth hormone receptor signaling	R-HSA-982772	5.681923e-02	1.246	0	0
Degradation of DVL	R-HSA-4641258	5.714430e-02	1.243	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	5.721448e-02	1.242	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	5.721448e-02	1.242	0	0
Glycogen storage diseases	R-HSA-3229121	5.721448e-02	1.242	0	0
EPHB-mediated forward signaling	R-HSA-3928662	5.826303e-02	1.235	0	0
Orc1 removal from chromatin	R-HSA-68949	5.838125e-02	1.234	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.961518e-02	1.225	0	0
Protein folding	R-HSA-391251	5.971461e-02	1.224	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	6.119934e-02	1.213	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.230183e-02	1.205	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	6.230183e-02	1.205	0	0
MAP kinase activation	R-HSA-450294	6.268544e-02	1.203	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	6.268544e-02	1.203	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	6.387568e-02	1.195	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	6.394632e-02	1.194	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	6.394632e-02	1.194	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	6.394632e-02	1.194	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	6.433893e-02	1.192	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	6.447428e-02	1.191	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	6.447428e-02	1.191	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	6.447428e-02	1.191	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	6.447428e-02	1.191	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	6.447428e-02	1.191	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	6.447428e-02	1.191	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	6.447428e-02	1.191	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	6.461579e-02	1.190	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.576748e-02	1.182	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.605699e-02	1.180	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	6.605699e-02	1.180	0	0
Interleukin-17 signaling	R-HSA-448424	6.605699e-02	1.180	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	6.605699e-02	1.180	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.643045e-02	1.178	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.643045e-02	1.178	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	6.819277e-02	1.166	0	0
DNA strand elongation	R-HSA-69190	6.835002e-02	1.165	0	0
G0 and Early G1	R-HSA-1538133	6.835002e-02	1.165	0	0
Neutrophil degranulation	R-HSA-6798695	6.870974e-02	1.163	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	6.982360e-02	1.156	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	6.998396e-02	1.155	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.998396e-02	1.155	0	0
Rab regulation of trafficking	R-HSA-9007101	7.058895e-02	1.151	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.103261e-02	1.149	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	7.103261e-02	1.149	0	0
Cellular response to chemical stress	R-HSA-9711123	7.235800e-02	1.141	0	0
TGFBR3 expression	R-HSA-9839394	7.300823e-02	1.137	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.319201e-02	1.136	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	7.502425e-02	1.125	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	7.598011e-02	1.119	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.633305e-02	1.117	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	7.660518e-02	1.116	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	7.660518e-02	1.116	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	7.766118e-02	1.110	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	7.827731e-02	1.106	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	7.827731e-02	1.106	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	8.006827e-02	1.097	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	8.006827e-02	1.097	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	8.006827e-02	1.097	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	8.116735e-02	1.091	0	0
Co-stimulation by CD28	R-HSA-389356	8.304016e-02	1.081	0	0
Vpu mediated degradation of CD4	R-HSA-180534	8.408883e-02	1.075	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.417043e-02	1.075	0	0
PKMTs methylate histone lysines	R-HSA-3214841	8.417043e-02	1.075	0	0
FLT3 Signaling	R-HSA-9607240	8.417043e-02	1.075	0	0
Formation of annular gap junctions	R-HSA-196025	8.495759e-02	1.071	0	0
Glycogen synthesis	R-HSA-3322077	8.717867e-02	1.060	0	0
Formation of definitive endoderm	R-HSA-9823730	8.717867e-02	1.060	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	8.900269e-02	1.051	0	0
Removal of the Flap Intermediate	R-HSA-69166	8.979169e-02	1.047	0	0
Regulation of KIT signaling	R-HSA-1433559	8.979169e-02	1.047	0	0
Adaptive Immune System	R-HSA-1280218	8.979826e-02	1.047	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	9.156550e-02	1.038	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	9.156550e-02	1.038	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.156550e-02	1.038	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	9.267308e-02	1.033	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.267308e-02	1.033	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.267308e-02	1.033	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.267308e-02	1.033	0	0
Gap junction assembly	R-HSA-190861	9.267308e-02	1.033	0	0
TICAM1 deficiency - HSE	R-HSA-5602566	1.700887e-01	0.769	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.700887e-01	0.769	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.700887e-01	0.769	0	0
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.086556e-01	0.964	0	0
IRS activation	R-HSA-74713	1.394433e-01	0.856	0	0
G2 Phase	R-HSA-68911	1.394433e-01	0.856	0	0
ARMS-mediated activation	R-HSA-170984	1.032803e-01	0.986	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.032803e-01	0.986	0	0
Gap junction degradation	R-HSA-190873	1.032803e-01	0.986	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.032803e-01	0.986	0	0
ALK mutants bind TKIs	R-HSA-9700645	1.032803e-01	0.986	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.718137e-01	0.765	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.718137e-01	0.765	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.718137e-01	0.765	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	1.718137e-01	0.765	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	1.718137e-01	0.765	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.230039e-01	0.910	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	1.230039e-01	0.910	0	0
2-LTR circle formation	R-HSA-164843	1.230039e-01	0.910	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	1.039857e-01	0.983	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.191307e-01	0.924	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.351632e-01	0.869	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	1.889340e-01	0.724	0	0
Polymerase switching	R-HSA-69091	1.889340e-01	0.724	0	0
Leading Strand Synthesis	R-HSA-69109	1.889340e-01	0.724	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.109011e-01	0.955	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.109011e-01	0.955	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.520143e-01	0.818	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.520143e-01	0.818	0	0
FGFR2 alternative splicing	R-HSA-6803529	1.238151e-01	0.907	0	0
HIV elongation arrest and recovery	R-HSA-167287	1.017139e-01	0.993	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	1.017139e-01	0.993	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.696110e-01	0.771	0	0
GAB1 signalosome	R-HSA-180292	1.696110e-01	0.771	0	0
Deadenylation of mRNA	R-HSA-429947	1.515850e-01	0.819	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.878776e-01	0.726	0	0
Long-term potentiation	R-HSA-9620244	1.663646e-01	0.779	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.424664e-01	0.846	0	0
HIV Transcription Elongation	R-HSA-167169	1.537192e-01	0.813	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.537192e-01	0.813	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.537192e-01	0.813	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.365412e-01	0.865	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	1.365412e-01	0.865	0	0
Peptide chain elongation	R-HSA-156902	1.266153e-01	0.898	0	0
UCH proteinases	R-HSA-5689603	1.670518e-01	0.777	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	1.825755e-01	0.739	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.880684e-01	0.726	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	1.481647e-01	0.829	0	0
Activation of the pre-replicative complex	R-HSA-68962	1.236844e-01	0.908	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	1.465824e-01	0.834	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.498220e-01	0.824	0	0
Processive synthesis on the lagging strand	R-HSA-69183	1.039857e-01	0.983	0	0
Integration of provirus	R-HSA-162592	1.659965e-01	0.780	0	0
Chaperonin-mediated protein folding	R-HSA-390466	1.198511e-01	0.921	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.268608e-01	0.897	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.394433e-01	0.856	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	1.032803e-01	0.986	0	0
Regulation of CDH11 function	R-HSA-9762292	1.230039e-01	0.910	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	1.238151e-01	0.907	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	1.132826e-01	0.946	0	0
Interferon alpha/beta signaling	R-HSA-909733	1.017463e-01	0.992	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.198105e-01	0.922	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	1.039857e-01	0.983	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	1.039857e-01	0.983	0	0
Regulation of IFNG signaling	R-HSA-877312	1.889340e-01	0.724	0	0
Platelet calcium homeostasis	R-HSA-418360	1.124256e-01	0.949	0	0
Budding and maturation of HIV virion	R-HSA-162588	1.354714e-01	0.868	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.351632e-01	0.869	0	0
Intracellular signaling by second messengers	R-HSA-9006925	1.214085e-01	0.916	0	0
PLC beta mediated events	R-HSA-112043	1.163680e-01	0.934	0	0
Myogenesis	R-HSA-525793	1.816855e-01	0.741	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	1.052142e-01	0.978	0	0
Pyrophosphate hydrolysis	R-HSA-71737	1.394433e-01	0.856	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.032803e-01	0.986	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	1.718137e-01	0.765	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.718137e-01	0.765	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	1.659965e-01	0.780	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	1.017275e-01	0.993	0	0
Nuclear RNA decay	R-HSA-9930044	1.605416e-01	0.794	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	1.773957e-01	0.751	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.465824e-01	0.834	0	0
Prolonged ERK activation events	R-HSA-169893	1.191307e-01	0.924	0	0
Neurexins and neuroligins	R-HSA-6794361	1.132826e-01	0.946	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.889340e-01	0.724	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.816855e-01	0.741	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	1.032803e-01	0.986	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.816855e-01	0.741	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.589842e-01	0.799	0	0
Intraflagellar transport	R-HSA-5620924	1.569735e-01	0.804	0	0
PCP/CE pathway	R-HSA-4086400	1.852024e-01	0.732	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	1.816855e-01	0.741	0	0
Rap1 signalling	R-HSA-392517	1.878776e-01	0.726	0	0
TBC/RABGAPs	R-HSA-8854214	1.086209e-01	0.964	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	1.268608e-01	0.897	0	0
G-protein mediated events	R-HSA-112040	1.681110e-01	0.774	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.109011e-01	0.955	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.124256e-01	0.949	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.467534e-01	0.833	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.467534e-01	0.833	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.467534e-01	0.833	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	1.700887e-01	0.769	0	0
Inhibition of PKR	R-HSA-169131	1.700887e-01	0.769	0	0
Nectin/Necl trans heterodimerization	R-HSA-420597	1.394433e-01	0.856	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.032803e-01	0.986	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	1.032803e-01	0.986	0	0
Unwinding of DNA	R-HSA-176974	1.032803e-01	0.986	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.659965e-01	0.780	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	1.112446e-01	0.954	0	0
Degradation of AXIN	R-HSA-4641257	1.212148e-01	0.916	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.212148e-01	0.916	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.661883e-01	0.779	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.605416e-01	0.794	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	1.306172e-01	0.884	0	0
Signaling by TGFBR3	R-HSA-9839373	1.365412e-01	0.865	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	1.130146e-01	0.947	0	0
Regulation of necroptotic cell death	R-HSA-5675482	1.605416e-01	0.794	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.069641e-01	0.971	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	1.087341e-01	0.964	0	0
NGF-stimulated transcription	R-HSA-9031628	1.569735e-01	0.804	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	1.351632e-01	0.869	0	0
PECAM1 interactions	R-HSA-210990	1.439647e-01	0.842	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.017139e-01	0.993	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.124256e-01	0.949	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	1.424664e-01	0.846	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.874380e-01	0.727	0	0
Protein-protein interactions at synapses	R-HSA-6794362	1.008443e-01	0.996	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	9.642173e-02	1.016	0	0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	1.718137e-01	0.765	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	1.718137e-01	0.765	0	0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	1.718137e-01	0.765	0	0
Regulation of Apoptosis	R-HSA-169911	1.017275e-01	0.993	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.605416e-01	0.794	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.881446e-01	0.726	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	1.677019e-01	0.775	0	0
Immune System	R-HSA-168256	1.670972e-01	0.777	0	0
Signaling by FGFR2	R-HSA-5654738	1.265138e-01	0.898	0	0
HCMV Late Events	R-HSA-9610379	1.019806e-01	0.991	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	1.008443e-01	0.996	1	1
Cellular response to mitochondrial stress	R-HSA-9840373	1.032803e-01	0.986	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.718137e-01	0.765	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	9.867942e-02	1.006	0	0
Platelet sensitization by LDL	R-HSA-432142	1.696110e-01	0.771	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.304100e-01	0.885	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.238151e-01	0.907	0	0
Suppression of phagosomal maturation	R-HSA-9637687	1.816855e-01	0.741	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.238151e-01	0.907	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.776674e-01	0.750	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.696110e-01	0.771	0	0
MHC class II antigen presentation	R-HSA-2132295	1.474853e-01	0.831	0	0
Stabilization of p53	R-HSA-69541	1.424664e-01	0.846	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	1.132826e-01	0.946	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	1.233656e-01	0.909	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.760142e-01	0.754	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.191307e-01	0.924	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	1.653684e-01	0.782	0	0
ABC-family proteins mediated transport	R-HSA-382556	1.020136e-01	0.991	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.718137e-01	0.765	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.351632e-01	0.869	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	1.439647e-01	0.842	0	0
Regulation of BACH1 activity	R-HSA-9708530	1.191307e-01	0.924	0	0
Interleukin-37 signaling	R-HSA-9008059	1.236844e-01	0.908	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.897817e-01	0.722	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	1.966083e-01	0.706	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	1.966083e-01	0.706	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	1.975033e-01	0.704	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.975033e-01	0.704	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.975033e-01	0.704	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.975033e-01	0.704	0	0
rRNA processing	R-HSA-72312	1.990564e-01	0.701	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.999777e-01	0.699	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	2.010581e-01	0.697	0	0
Signaling by FGFR4	R-HSA-5654743	2.025059e-01	0.694	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	2.025059e-01	0.694	0	0
Autointegration results in viral DNA circles	R-HSA-177539	2.052418e-01	0.688	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	2.052418e-01	0.688	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.052418e-01	0.688	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.052418e-01	0.688	0	0
Ribosome-associated quality control	R-HSA-9948299	2.052516e-01	0.688	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	2.067366e-01	0.685	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.126160e-01	0.672	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.126160e-01	0.672	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.126160e-01	0.672	0	0
Interleukin-6 signaling	R-HSA-1059683	2.126160e-01	0.672	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.126160e-01	0.672	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.144647e-01	0.669	0	0
G1 Phase	R-HSA-69236	2.155467e-01	0.666	0	0
Cyclin D associated events in G1	R-HSA-69231	2.155467e-01	0.666	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.155467e-01	0.666	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.155467e-01	0.666	0	0
Cellular response to starvation	R-HSA-9711097	2.160610e-01	0.665	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.182557e-01	0.661	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	2.222709e-01	0.653	0	0
Signaling by FGFR	R-HSA-190236	2.232493e-01	0.651	0	0
Lagging Strand Synthesis	R-HSA-69186	2.261101e-01	0.646	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	2.261101e-01	0.646	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.261101e-01	0.646	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	2.261101e-01	0.646	0	0
Signaling by FGFR3	R-HSA-5654741	2.288817e-01	0.640	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	2.288817e-01	0.640	0	0
Potential therapeutics for SARS	R-HSA-9679191	2.290583e-01	0.640	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.304460e-01	0.637	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	2.368872e-01	0.625	0	0
MECP2 regulates transcription factors	R-HSA-9022707	2.392832e-01	0.621	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	2.392832e-01	0.621	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.392832e-01	0.621	0	0
SOS-mediated signalling	R-HSA-112412	2.392832e-01	0.621	0	0
Recycling of eIF2:GDP	R-HSA-72731	2.392832e-01	0.621	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.392832e-01	0.621	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	2.392832e-01	0.621	0	0
CHL1 interactions	R-HSA-447041	2.392832e-01	0.621	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	2.392832e-01	0.621	0	0
Signaling by ERBB4	R-HSA-1236394	2.398262e-01	0.620	0	0
Mitochondrial transcription initiation	R-HSA-163282	2.439618e-01	0.613	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	2.439618e-01	0.613	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	2.439618e-01	0.613	0	0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	2.439618e-01	0.613	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	2.439618e-01	0.613	0	0
TRAF3 deficiency - HSE	R-HSA-5602571	2.439618e-01	0.613	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	2.439618e-01	0.613	0	0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	2.439618e-01	0.613	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.439618e-01	0.613	0	0
Interleukin-1 family signaling	R-HSA-446652	2.440706e-01	0.612	0	0
Cellular response to hypoxia	R-HSA-1234174	2.454561e-01	0.610	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	2.457850e-01	0.609	0	0
Toll-like Receptor Cascades	R-HSA-168898	2.462383e-01	0.609	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.474767e-01	0.606	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.474767e-01	0.606	0	0
Ion homeostasis	R-HSA-5578775	2.510150e-01	0.600	0	0
NRAGE signals death through JNK	R-HSA-193648	2.510150e-01	0.600	0	0
Signaling by FGFR1	R-HSA-5654736	2.510150e-01	0.600	0	0
Interleukin-1 signaling	R-HSA-9020702	2.512891e-01	0.600	0	0
TCR signaling	R-HSA-202403	2.536390e-01	0.596	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	2.563414e-01	0.591	0	0
RAS processing	R-HSA-9648002	2.611378e-01	0.583	0	0
Plasma lipoprotein clearance	R-HSA-8964043	2.611378e-01	0.583	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.616000e-01	0.582	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.616000e-01	0.582	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	2.644050e-01	0.578	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	2.644050e-01	0.578	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.648169e-01	0.577	0	0
Notch-HLH transcription pathway	R-HSA-350054	2.660905e-01	0.575	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	2.660905e-01	0.575	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	2.660905e-01	0.575	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.735642e-01	0.563	0	0
Type I hemidesmosome assembly	R-HSA-446107	2.735642e-01	0.563	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	2.735642e-01	0.563	0	0
MET receptor recycling	R-HSA-8875656	2.735642e-01	0.563	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	2.735642e-01	0.563	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.735642e-01	0.563	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	2.735642e-01	0.563	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.765884e-01	0.558	1	1
Glycogen metabolism	R-HSA-8982491	2.767318e-01	0.558	0	0
Signaling by WNT in cancer	R-HSA-4791275	2.824192e-01	0.549	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.846945e-01	0.546	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.846945e-01	0.546	0	0
ABC transporter disorders	R-HSA-5619084	2.850683e-01	0.545	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	2.865457e-01	0.543	0	0
Syndecan interactions	R-HSA-3000170	2.865457e-01	0.543	0	0
Activation of SMO	R-HSA-5635838	2.866153e-01	0.543	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	2.866153e-01	0.543	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.866153e-01	0.543	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.866153e-01	0.543	0	0
Eukaryotic Translation Termination	R-HSA-72764	2.893027e-01	0.539	0	0
Regulation of beta-cell development	R-HSA-186712	2.901916e-01	0.537	0	0
Signaling by NTRKs	R-HSA-166520	2.917090e-01	0.535	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.917791e-01	0.535	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.917791e-01	0.535	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	2.919285e-01	0.535	0	0
Sensory processing of sound	R-HSA-9659379	2.967457e-01	0.528	0	0
Activation of ATR in response to replication stress	R-HSA-176187	3.002367e-01	0.523	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.002367e-01	0.523	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	3.002367e-01	0.523	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.002367e-01	0.523	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.002367e-01	0.523	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.072135e-01	0.513	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.072135e-01	0.513	0	0
Lipophagy	R-HSA-9613354	3.077728e-01	0.512	0	0
WNT mediated activation of DVL	R-HSA-201688	3.077728e-01	0.512	0	0
Calcineurin activates NFAT	R-HSA-2025928	3.077728e-01	0.512	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.077728e-01	0.512	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	3.077728e-01	0.512	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	3.077728e-01	0.512	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.077728e-01	0.512	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	3.085124e-01	0.511	0	0
Translation of Structural Proteins	R-HSA-9683701	3.085124e-01	0.511	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	3.085446e-01	0.511	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.112632e-01	0.507	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.112632e-01	0.507	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.112632e-01	0.507	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.112632e-01	0.507	0	0
Transcription from mitochondrial promoters	R-HSA-75944	3.112632e-01	0.507	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	3.112632e-01	0.507	0	0
C6 deamination of adenosine	R-HSA-75102	3.112632e-01	0.507	0	0
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	3.112632e-01	0.507	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	3.137462e-01	0.503	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.182233e-01	0.497	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	3.182233e-01	0.497	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	3.182233e-01	0.497	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	3.210702e-01	0.493	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	3.246338e-01	0.489	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	3.280239e-01	0.484	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	3.324524e-01	0.478	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	3.363339e-01	0.473	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	3.370459e-01	0.472	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	3.370459e-01	0.472	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.370459e-01	0.472	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.370459e-01	0.472	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	3.370459e-01	0.472	0	0
Signaling by SCF-KIT	R-HSA-1433557	3.408664e-01	0.467	0	0
Folding of actin by CCT/TriC	R-HSA-390450	3.416504e-01	0.466	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	3.416504e-01	0.466	0	0
PI3K/AKT activation	R-HSA-198203	3.416504e-01	0.466	0	0
Signal attenuation	R-HSA-74749	3.416504e-01	0.466	0	0
Interleukin-27 signaling	R-HSA-9020956	3.416504e-01	0.466	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.416504e-01	0.466	0	0
Signaling by Leptin	R-HSA-2586552	3.416504e-01	0.466	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	3.489104e-01	0.457	0	0
PERK regulates gene expression	R-HSA-381042	3.545250e-01	0.450	0	0
Signalling to ERKs	R-HSA-187687	3.545250e-01	0.450	0	0
Netrin-1 signaling	R-HSA-373752	3.571789e-01	0.447	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.622322e-01	0.441	0	0
PKA activation	R-HSA-163615	3.622322e-01	0.441	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	3.622322e-01	0.441	0	0
Mismatch Repair	R-HSA-5358508	3.622322e-01	0.441	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	3.622322e-01	0.441	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	3.658068e-01	0.437	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	3.715878e-01	0.430	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	3.725772e-01	0.429	0	0
Axonal growth stimulation	R-HSA-209563	3.725772e-01	0.429	0	0
MET activates PTPN11	R-HSA-8865999	3.725772e-01	0.429	0	0
Defective HPRT1 disrupts guanine and hypoxanthine salvage	R-HSA-9734281	3.725772e-01	0.429	0	0
Defective ABCC2 causes DJS	R-HSA-5679001	3.725772e-01	0.429	0	0
Inhibition of nitric oxide production	R-HSA-9636249	3.725772e-01	0.429	0	0
MET interacts with TNS proteins	R-HSA-8875513	3.725772e-01	0.429	0	0
Histamine receptors	R-HSA-390650	3.725772e-01	0.429	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.727544e-01	0.429	0	0
RNA Polymerase III Transcription	R-HSA-74158	3.727544e-01	0.429	0	0
RUNX2 regulates bone development	R-HSA-8941326	3.727544e-01	0.429	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.749851e-01	0.426	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	3.749851e-01	0.426	0	0
Formation of the posterior neural plate	R-HSA-9832991	3.749851e-01	0.426	0	0
Viral mRNA Translation	R-HSA-192823	3.760496e-01	0.425	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	3.811712e-01	0.419	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	3.872635e-01	0.412	0	0
Maturation of nucleoprotein	R-HSA-9694631	3.872635e-01	0.412	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	3.899221e-01	0.409	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.906624e-01	0.408	0	0
Formation of the Early Elongation Complex	R-HSA-113418	3.906624e-01	0.408	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	3.906624e-01	0.408	0	0
Translation of Structural Proteins	R-HSA-9694635	3.966851e-01	0.402	0	0
PIP3 activates AKT signaling	R-HSA-1257604	4.049483e-01	0.393	0	0
Pyruvate metabolism	R-HSA-70268	4.057721e-01	0.392	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	4.074285e-01	0.390	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	4.076052e-01	0.390	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.076052e-01	0.390	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.076052e-01	0.390	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.076052e-01	0.390	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.076052e-01	0.390	0	0
MET promotes cell motility	R-HSA-8875878	4.091680e-01	0.388	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	4.114130e-01	0.386	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.114130e-01	0.386	0	0
DARPP-32 events	R-HSA-180024	4.114130e-01	0.386	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	4.114130e-01	0.386	0	0
Signal transduction by L1	R-HSA-445144	4.120506e-01	0.385	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	4.136624e-01	0.383	0	0
Regulated Necrosis	R-HSA-5218859	4.138514e-01	0.383	0	0
Gluconeogenesis	R-HSA-70263	4.226301e-01	0.374	0	0
Signaling by ALK	R-HSA-201556	4.272771e-01	0.369	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.284360e-01	0.368	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.284360e-01	0.368	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.284360e-01	0.368	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.284360e-01	0.368	0	0
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.284360e-01	0.368	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.284360e-01	0.368	0	0
Signaling by MAP2K mutants	R-HSA-9652169	4.284360e-01	0.368	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.284360e-01	0.368	0	0
NADE modulates death signalling	R-HSA-205025	4.284360e-01	0.368	0	0
ER-Phagosome pathway	R-HSA-1236974	4.304029e-01	0.366	0	0
Peroxisomal protein import	R-HSA-9033241	4.331046e-01	0.363	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	4.331046e-01	0.363	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	4.365140e-01	0.360	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	4.365140e-01	0.360	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.393738e-01	0.357	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	4.393738e-01	0.357	0	0
Scavenging by Class F Receptors	R-HSA-3000484	4.393738e-01	0.357	0	0
Interleukin-35 Signalling	R-HSA-8984722	4.393738e-01	0.357	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.393738e-01	0.357	0	0
OAS antiviral response	R-HSA-8983711	4.393738e-01	0.357	0	0
Downstream TCR signaling	R-HSA-202424	4.426998e-01	0.354	0	0
Stimuli-sensing channels	R-HSA-2672351	4.429479e-01	0.354	0	0
Diseases of Immune System	R-HSA-5260271	4.452741e-01	0.351	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	4.452741e-01	0.351	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	4.452741e-01	0.351	0	0
Trafficking of AMPA receptors	R-HSA-399719	4.524051e-01	0.344	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	4.605835e-01	0.337	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.631267e-01	0.334	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.631267e-01	0.334	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.701841e-01	0.328	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.701841e-01	0.328	0	0
Frs2-mediated activation	R-HSA-170968	4.701841e-01	0.328	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	4.719998e-01	0.326	0	0
Selenocysteine synthesis	R-HSA-2408557	4.719998e-01	0.326	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.744110e-01	0.324	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	4.775690e-01	0.321	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	4.793249e-01	0.319	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	4.793249e-01	0.319	0	0
PTK6 Down-Regulation	R-HSA-8849472	4.793249e-01	0.319	0	0
Activation of AKT2	R-HSA-165158	4.793249e-01	0.319	0	0
Reelin signalling pathway	R-HSA-8866376	4.793249e-01	0.319	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.793249e-01	0.319	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.793249e-01	0.319	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	4.793249e-01	0.319	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.793249e-01	0.319	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.793249e-01	0.319	0	0
NrCAM interactions	R-HSA-447038	4.793249e-01	0.319	0	0
Co-inhibition by BTLA	R-HSA-9927353	4.793249e-01	0.319	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.793249e-01	0.319	0	0
Assembly of Viral Components at the Budding Site	R-HSA-168316	4.793249e-01	0.319	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	4.793803e-01	0.319	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	4.808044e-01	0.318	0	0
Intra-Golgi traffic	R-HSA-6811438	4.808044e-01	0.318	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	4.841980e-01	0.315	0	0
Signaling by KIT in disease	R-HSA-9669938	4.841980e-01	0.315	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	4.924212e-01	0.308	0	0
G-protein beta:gamma signalling	R-HSA-397795	4.924212e-01	0.308	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	4.924212e-01	0.308	0	0
Signaling by FGFR in disease	R-HSA-1226099	4.964993e-01	0.304	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	4.999549e-01	0.301	0	0
Signal regulatory protein family interactions	R-HSA-391160	4.999549e-01	0.301	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	5.028762e-01	0.299	0	0
Opioid Signalling	R-HSA-111885	5.065389e-01	0.295	0	0
Ion transport by P-type ATPases	R-HSA-936837	5.066950e-01	0.295	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.066950e-01	0.295	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.073046e-01	0.295	0	0
Resolution of D-Loop Structures	R-HSA-5693537	5.119667e-01	0.291	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	5.119667e-01	0.291	0	0
Circadian clock	R-HSA-9909396	5.141171e-01	0.289	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.256856e-01	0.279	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.256856e-01	0.279	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.256856e-01	0.279	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.256856e-01	0.279	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.256856e-01	0.279	0	0
Phosphorylation of Emi1	R-HSA-176417	5.256856e-01	0.279	0	0
PDE3B signalling	R-HSA-165160	5.256856e-01	0.279	0	0
Synthesis of PS	R-HSA-1483101	5.256856e-01	0.279	0	0
Cam-PDE 1 activation	R-HSA-111957	5.256856e-01	0.279	0	0
PKB-mediated events	R-HSA-109703	5.256856e-01	0.279	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	5.256856e-01	0.279	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	5.256856e-01	0.279	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	5.256856e-01	0.279	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.256856e-01	0.279	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	5.256856e-01	0.279	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.256856e-01	0.279	0	0
DCC mediated attractive signaling	R-HSA-418885	5.286272e-01	0.277	0	0
Formation of the anterior neural plate	R-HSA-9823739	5.286272e-01	0.277	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.286272e-01	0.277	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	5.298586e-01	0.276	0	0
Mitochondrial RNA degradation	R-HSA-9836573	5.298586e-01	0.276	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	5.298586e-01	0.276	0	0
Interleukin-6 family signaling	R-HSA-6783589	5.298586e-01	0.276	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	5.311599e-01	0.275	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	5.311599e-01	0.275	0	0
RMTs methylate histone arginines	R-HSA-3214858	5.325185e-01	0.274	0	0
G alpha (12/13) signalling events	R-HSA-416482	5.496872e-01	0.260	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.499727e-01	0.260	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.518223e-01	0.258	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.561605e-01	0.255	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	5.561605e-01	0.255	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	5.561605e-01	0.255	0	0
Differentiation of T cells	R-HSA-9945266	5.561605e-01	0.255	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	5.561605e-01	0.255	0	0
Developmental Cell Lineages	R-HSA-9734767	5.563509e-01	0.255	0	0
Antigen processing-Cross presentation	R-HSA-1236975	5.625792e-01	0.250	0	0
Transcription of the HIV genome	R-HSA-167172	5.631276e-01	0.249	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	5.636169e-01	0.249	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.679209e-01	0.246	0	0
Signaling by LTK in cancer	R-HSA-9842640	5.679209e-01	0.246	0	0
Erythropoietin activates STAT5	R-HSA-9027283	5.679209e-01	0.246	0	0
Neurofascin interactions	R-HSA-447043	5.679209e-01	0.246	0	0
CREB phosphorylation	R-HSA-199920	5.679209e-01	0.246	0	0
CREB3 factors activate genes	R-HSA-8874211	5.679209e-01	0.246	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.679209e-01	0.246	0	0
G1/S-Specific Transcription	R-HSA-69205	5.683804e-01	0.245	0	0
RET signaling	R-HSA-8853659	5.683804e-01	0.245	0	0
TRP channels	R-HSA-3295583	5.731652e-01	0.242	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	5.767767e-01	0.239	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	5.825304e-01	0.235	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.825304e-01	0.235	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.825304e-01	0.235	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	5.825304e-01	0.235	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.825304e-01	0.235	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	5.832777e-01	0.234	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.880075e-01	0.231	0	0
Gastrulation	R-HSA-9758941	5.919067e-01	0.228	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.938630e-01	0.226	0	0
Cristae formation	R-HSA-8949613	5.938630e-01	0.226	0	0
IRE1alpha activates chaperones	R-HSA-381070	5.981263e-01	0.223	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.038986e-01	0.219	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.038986e-01	0.219	0	0
Inositol phosphate metabolism	R-HSA-1483249	6.055096e-01	0.218	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	6.063976e-01	0.217	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.063976e-01	0.217	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.063976e-01	0.217	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.063976e-01	0.217	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	6.063976e-01	0.217	0	0
Disinhibition of SNARE formation	R-HSA-114516	6.063976e-01	0.217	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.063976e-01	0.217	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.063976e-01	0.217	0	0
DAG1 core M1 glycosylations	R-HSA-8932506	6.063976e-01	0.217	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.063976e-01	0.217	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.063976e-01	0.217	0	0
VLDL clearance	R-HSA-8964046	6.063976e-01	0.217	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	6.063976e-01	0.217	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.063976e-01	0.217	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.063976e-01	0.217	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.077258e-01	0.216	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	6.077258e-01	0.216	0	0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	6.077258e-01	0.216	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	6.077258e-01	0.216	0	0
Specification of primordial germ cells	R-HSA-9827857	6.077258e-01	0.216	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	6.077258e-01	0.216	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	6.209760e-01	0.207	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.209760e-01	0.207	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.209760e-01	0.207	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	6.209760e-01	0.207	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	6.214007e-01	0.207	0	0
Formation of paraxial mesoderm	R-HSA-9793380	6.214007e-01	0.207	0	0
PI3K Cascade	R-HSA-109704	6.281054e-01	0.202	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.317467e-01	0.199	0	0
Polo-like kinase mediated events	R-HSA-156711	6.317467e-01	0.199	0	0
PKA activation in glucagon signalling	R-HSA-164378	6.317467e-01	0.199	0	0
Nephron development	R-HSA-9831926	6.317467e-01	0.199	0	0
mRNA Capping	R-HSA-72086	6.332537e-01	0.198	0	0
Regulation of gene expression in beta cells	R-HSA-210745	6.332537e-01	0.198	0	0
RSV-host interactions	R-HSA-9833110	6.395505e-01	0.194	0	0
Translation	R-HSA-72766	6.412212e-01	0.193	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.414500e-01	0.193	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.414500e-01	0.193	0	0
phospho-PLA2 pathway	R-HSA-111995	6.414500e-01	0.193	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.414500e-01	0.193	0	0
Activation of RAS in B cells	R-HSA-1169092	6.414500e-01	0.193	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.414500e-01	0.193	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.414500e-01	0.193	0	0
FGFR1b ligand binding and activation	R-HSA-190370	6.414500e-01	0.193	0	0
Interleukin-9 signaling	R-HSA-8985947	6.414500e-01	0.193	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	6.414500e-01	0.193	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.414500e-01	0.193	0	0
TGFBR3 PTM regulation	R-HSA-9839383	6.414500e-01	0.193	0	0
DAG1 core M2 glycosylations	R-HSA-8932504	6.414500e-01	0.193	0	0
Nucleotide salvage defects	R-HSA-9734207	6.414500e-01	0.193	0	0
Sodium/Proton exchangers	R-HSA-425986	6.414500e-01	0.193	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	6.519246e-01	0.186	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	6.519246e-01	0.186	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	6.519246e-01	0.186	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	6.519246e-01	0.186	0	0
Iron uptake and transport	R-HSA-917937	6.539967e-01	0.184	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.546024e-01	0.184	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.546024e-01	0.184	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	6.546024e-01	0.184	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.546024e-01	0.184	0	0
The NLRP3 inflammasome	R-HSA-844456	6.546024e-01	0.184	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	6.546024e-01	0.184	0	0
STING mediated induction of host immune responses	R-HSA-1834941	6.546024e-01	0.184	0	0
Ion channel transport	R-HSA-983712	6.557204e-01	0.183	0	0
Hemostasis	R-HSA-109582	6.569056e-01	0.182	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.572012e-01	0.182	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	6.572012e-01	0.182	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	6.595354e-01	0.181	0	0
Platelet homeostasis	R-HSA-418346	6.601866e-01	0.180	0	0
IGF1R signaling cascade	R-HSA-2428924	6.614423e-01	0.180	0	0
p75NTR regulates axonogenesis	R-HSA-193697	6.733828e-01	0.172	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.733828e-01	0.172	0	0
Interleukin-21 signaling	R-HSA-9020958	6.733828e-01	0.172	0	0
mRNA Editing	R-HSA-75072	6.733828e-01	0.172	0	0
Regulation of signaling by NODAL	R-HSA-1433617	6.733828e-01	0.172	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	6.733828e-01	0.172	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	6.733828e-01	0.172	0	0
Interleukin-1 processing	R-HSA-448706	6.733828e-01	0.172	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	6.733828e-01	0.172	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	6.733828e-01	0.172	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.741836e-01	0.171	0	0
Mitochondrial biogenesis	R-HSA-1592230	6.753917e-01	0.170	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.763099e-01	0.170	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	6.763099e-01	0.170	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.763099e-01	0.170	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.763099e-01	0.170	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.763099e-01	0.170	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.763099e-01	0.170	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	6.763099e-01	0.170	0	0
Protein hydroxylation	R-HSA-9629569	6.763099e-01	0.170	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	6.763099e-01	0.170	0	0
Interferon gamma signaling	R-HSA-877300	6.785365e-01	0.168	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	6.844871e-01	0.165	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.847616e-01	0.164	0	0
Post-translational protein phosphorylation	R-HSA-8957275	6.857215e-01	0.164	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	6.871953e-01	0.163	0	0
FOXO-mediated transcription	R-HSA-9614085	6.958002e-01	0.158	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	6.968925e-01	0.157	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	6.968925e-01	0.157	0	0
Matriglycan biosynthesis on DAG1	R-HSA-9939291	6.968925e-01	0.157	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	6.968925e-01	0.157	0	0
ERK/MAPK targets	R-HSA-198753	6.968925e-01	0.157	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	6.968925e-01	0.157	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	7.004928e-01	0.155	0	0
MAPK3 (ERK1) activation	R-HSA-110056	7.024733e-01	0.153	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.024733e-01	0.153	0	0
DNA replication initiation	R-HSA-68952	7.024733e-01	0.153	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.024733e-01	0.153	0	0
Formation of apoptosome	R-HSA-111458	7.024733e-01	0.153	0	0
Binding and entry of HIV virion	R-HSA-173107	7.024733e-01	0.153	0	0
Regulation of the apoptosome activity	R-HSA-9627069	7.024733e-01	0.153	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.024733e-01	0.153	0	0
CASP4 inflammasome assembly	R-HSA-9948001	7.024733e-01	0.153	0	0
Maturation of spike protein	R-HSA-9683686	7.024733e-01	0.153	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	7.108420e-01	0.148	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.163782e-01	0.145	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.163782e-01	0.145	0	0
Selenoamino acid metabolism	R-HSA-2408522	7.176895e-01	0.144	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	7.197171e-01	0.143	0	0
Heme degradation	R-HSA-189483	7.197171e-01	0.143	0	0
Protein localization	R-HSA-9609507	7.218152e-01	0.142	0	0
IRS-mediated signalling	R-HSA-112399	7.232845e-01	0.141	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.289744e-01	0.137	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	7.289744e-01	0.137	0	0
vRNA Synthesis	R-HSA-192814	7.289744e-01	0.137	0	0
vRNP Assembly	R-HSA-192905	7.289744e-01	0.137	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	7.289744e-01	0.137	0	0
Propionyl-CoA catabolism	R-HSA-71032	7.289744e-01	0.137	0	0
Bicarbonate transporters	R-HSA-425381	7.289744e-01	0.137	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.289744e-01	0.137	0	0
Transport of RCbl within the body	R-HSA-9758890	7.289744e-01	0.137	0	0
Dissolution of Fibrin Clot	R-HSA-75205	7.289744e-01	0.137	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.347992e-01	0.134	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.347992e-01	0.134	0	0
LDL clearance	R-HSA-8964038	7.347992e-01	0.134	0	0
Cellular hexose transport	R-HSA-189200	7.347992e-01	0.134	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.347992e-01	0.134	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	7.349630e-01	0.134	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	7.349630e-01	0.134	0	0
eNOS activation	R-HSA-203615	7.349630e-01	0.134	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.349630e-01	0.134	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	7.401142e-01	0.131	0	0
Diseases of DNA repair	R-HSA-9675135	7.401142e-01	0.131	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	7.426878e-01	0.129	0	0
Extension of Telomeres	R-HSA-180786	7.470046e-01	0.127	0	0
Post-translational protein modification	R-HSA-597592	7.510299e-01	0.124	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.521905e-01	0.124	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.521905e-01	0.124	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.521905e-01	0.124	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.531164e-01	0.123	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.531164e-01	0.123	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	7.531164e-01	0.123	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.531164e-01	0.123	0	0
Plasmalogen biosynthesis	R-HSA-75896	7.531164e-01	0.123	0	0
ERKs are inactivated	R-HSA-202670	7.531164e-01	0.123	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.531164e-01	0.123	0	0
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.531164e-01	0.123	0	0
Activation of RAC1	R-HSA-428540	7.531164e-01	0.123	0	0
Sodium/Calcium exchangers	R-HSA-425561	7.531164e-01	0.123	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.545049e-01	0.122	0	0
RAB geranylgeranylation	R-HSA-8873719	7.582856e-01	0.120	0	0
tRNA Aminoacylation	R-HSA-379724	7.582856e-01	0.120	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.582856e-01	0.120	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	7.751092e-01	0.111	0	0
Repression of WNT target genes	R-HSA-4641265	7.751092e-01	0.111	0	0
GRB2 events in EGFR signaling	R-HSA-179812	7.751092e-01	0.111	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	7.751092e-01	0.111	0	0
Signaling by LTK	R-HSA-9842663	7.751092e-01	0.111	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.751092e-01	0.111	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.751092e-01	0.111	0	0
MET activates RAS signaling	R-HSA-8851805	7.751092e-01	0.111	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.751092e-01	0.111	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	7.767737e-01	0.110	0	0
NCAM1 interactions	R-HSA-419037	7.767737e-01	0.110	0	0
Signaling by PDGF	R-HSA-186797	7.797050e-01	0.108	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	7.840344e-01	0.106	0	0
Tight junction interactions	R-HSA-420029	7.840344e-01	0.106	0	0
Acyl chain remodelling of PS	R-HSA-1482801	7.840344e-01	0.106	0	0
HDMs demethylate histones	R-HSA-3214842	7.840344e-01	0.106	0	0
Hyaluronan degradation	R-HSA-2160916	7.840344e-01	0.106	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.840344e-01	0.106	0	0
Formation of the nephric duct	R-HSA-9830364	7.840344e-01	0.106	0	0
Interleukin-7 signaling	R-HSA-1266695	7.840344e-01	0.106	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	7.894486e-01	0.103	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.898519e-01	0.102	0	0
Formation of axial mesoderm	R-HSA-9796292	7.951441e-01	0.100	0	0
Microbial factors inhibit CASP4 activity	R-HSA-9956593	7.951441e-01	0.100	0	0
FGFR1c ligand binding and activation	R-HSA-190373	7.951441e-01	0.100	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	7.951441e-01	0.100	0	0
Diseases of nucleotide metabolism	R-HSA-9735804	7.951441e-01	0.100	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	7.951441e-01	0.100	0	0
Maturation of nucleoprotein	R-HSA-9683610	7.951441e-01	0.100	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	7.951441e-01	0.100	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	7.985655e-01	0.098	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.985655e-01	0.098	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	7.985655e-01	0.098	0	0
The phototransduction cascade	R-HSA-2514856	7.987678e-01	0.098	0	0
Insulin receptor signalling cascade	R-HSA-74751	7.996305e-01	0.097	0	0
Infectious disease	R-HSA-5663205	7.998113e-01	0.097	0	0
Disorders of transmembrane transporters	R-HSA-5619115	8.107809e-01	0.091	0	0
Integrin cell surface interactions	R-HSA-216083	8.109847e-01	0.091	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.122229e-01	0.090	0	0
Insulin processing	R-HSA-264876	8.122229e-01	0.090	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	8.130038e-01	0.090	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	8.130038e-01	0.090	0	0
Generation of second messenger molecules	R-HSA-202433	8.130038e-01	0.090	0	0
Retrograde neurotrophin signalling	R-HSA-177504	8.133952e-01	0.090	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.133952e-01	0.090	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	8.133952e-01	0.090	0	0
Hydrolysis of LPC	R-HSA-1483115	8.133952e-01	0.090	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	8.133952e-01	0.090	0	0
Physiological factors	R-HSA-5578768	8.133952e-01	0.090	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.133952e-01	0.090	0	0
Non-canonical inflammasome activation	R-HSA-9686114	8.133952e-01	0.090	0	0
Acyl chain remodeling of CL	R-HSA-1482798	8.133952e-01	0.090	0	0
Zinc transporters	R-HSA-435354	8.133952e-01	0.090	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.133952e-01	0.090	0	0
Amino acids regulate mTORC1	R-HSA-9639288	8.190267e-01	0.087	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	8.250468e-01	0.084	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.250468e-01	0.084	0	0
Inflammasomes	R-HSA-622312	8.250468e-01	0.084	0	0
Pyroptosis	R-HSA-5620971	8.250468e-01	0.084	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.300213e-01	0.081	0	0
Erythropoietin activates RAS	R-HSA-9027284	8.300213e-01	0.081	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.300213e-01	0.081	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	8.300213e-01	0.081	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.300213e-01	0.081	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	8.300213e-01	0.081	0	0
Transport and metabolism of PAPS	R-HSA-174362	8.300213e-01	0.081	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	8.300213e-01	0.081	0	0
Biotin transport and metabolism	R-HSA-196780	8.300213e-01	0.081	0	0
p38MAPK events	R-HSA-171007	8.300213e-01	0.081	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.300213e-01	0.081	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.300213e-01	0.081	0	0
DNA Damage Reversal	R-HSA-73942	8.300213e-01	0.081	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	8.351161e-01	0.078	0	0
Disease	R-HSA-1643685	8.369045e-01	0.077	0	0
Signaling by Erythropoietin	R-HSA-9006335	8.370773e-01	0.077	0	0
G alpha (z) signalling events	R-HSA-418597	8.375746e-01	0.077	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	8.435890e-01	0.074	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.441236e-01	0.074	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.451669e-01	0.073	0	0
Killing mechanisms	R-HSA-9664420	8.451669e-01	0.073	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	8.451669e-01	0.073	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.451669e-01	0.073	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.451669e-01	0.073	0	0
Attachment and Entry	R-HSA-9678110	8.451669e-01	0.073	0	0
Atorvastatin ADME	R-HSA-9754706	8.451669e-01	0.073	0	0
Virus Assembly and Release	R-HSA-168268	8.451669e-01	0.073	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.483540e-01	0.071	0	0
Cytoprotection by HMOX1	R-HSA-9707564	8.498157e-01	0.071	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.589156e-01	0.066	0	0
Molecules associated with elastic fibres	R-HSA-2129379	8.589156e-01	0.066	0	0
Cargo concentration in the ER	R-HSA-5694530	8.589156e-01	0.066	0	0
Downstream signal transduction	R-HSA-186763	8.589156e-01	0.066	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	8.589638e-01	0.066	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.589638e-01	0.066	0	0
Coenzyme A biosynthesis	R-HSA-196783	8.589638e-01	0.066	0	0
Proteasome assembly	R-HSA-9907900	8.622847e-01	0.064	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	8.654105e-01	0.063	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	8.667642e-01	0.062	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.688000e-01	0.061	0	0
DAG1 glycosylations	R-HSA-8931838	8.688000e-01	0.061	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.690364e-01	0.061	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.699070e-01	0.061	0	0
Somitogenesis	R-HSA-9824272	8.706480e-01	0.060	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.715321e-01	0.060	0	0
Choline catabolism	R-HSA-6798163	8.715321e-01	0.060	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.715321e-01	0.060	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	8.721933e-01	0.059	0	0
Adipogenesis	R-HSA-9843745	8.768673e-01	0.057	0	0
Cardiogenesis	R-HSA-9733709	8.780440e-01	0.056	0	0
Transmission across Chemical Synapses	R-HSA-112315	8.788043e-01	0.056	0	0
Apoptotic factor-mediated response	R-HSA-111471	8.829810e-01	0.054	0	0
FGFR1 ligand binding and activation	R-HSA-190242	8.829810e-01	0.054	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	8.829810e-01	0.054	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	8.829810e-01	0.054	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	8.829810e-01	0.054	0	0
Acyl chain remodelling of PC	R-HSA-1482788	8.866831e-01	0.052	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	8.866831e-01	0.052	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	8.875448e-01	0.052	0	0
Mitochondrial protein import	R-HSA-1268020	8.903711e-01	0.050	0	0
Heme signaling	R-HSA-9707616	8.903711e-01	0.050	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.903711e-01	0.050	0	0
Metal ion SLC transporters	R-HSA-425410	8.931010e-01	0.049	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	8.934102e-01	0.049	0	0
Other interleukin signaling	R-HSA-449836	8.934102e-01	0.049	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.934102e-01	0.049	0	0
tRNA processing	R-HSA-72306	8.947030e-01	0.048	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.947518e-01	0.048	0	0
Hyaluronan metabolism	R-HSA-2142845	8.947518e-01	0.048	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.947518e-01	0.048	0	0
Neurotransmitter release cycle	R-HSA-112310	8.981847e-01	0.047	0	0
Neddylation	R-HSA-8951664	9.021570e-01	0.045	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.022830e-01	0.045	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.029105e-01	0.044	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	9.029105e-01	0.044	0	0
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.029105e-01	0.044	0	0
Signaling by NODAL	R-HSA-1181150	9.029105e-01	0.044	0	0
Acyl chain remodelling of PI	R-HSA-1482922	9.029105e-01	0.044	0	0
Creatine metabolism	R-HSA-71288	9.029105e-01	0.044	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	9.060602e-01	0.043	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.092904e-01	0.041	0	0
GPVI-mediated activation cascade	R-HSA-114604	9.093085e-01	0.041	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.093085e-01	0.041	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.093085e-01	0.041	0	0
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.115645e-01	0.040	0	0
Basigin interactions	R-HSA-210991	9.115645e-01	0.040	0	0
Signalling to RAS	R-HSA-167044	9.115645e-01	0.040	0	0
Acyl chain remodelling of PG	R-HSA-1482925	9.115645e-01	0.040	0	0
Signaling by Insulin receptor	R-HSA-74752	9.125283e-01	0.040	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.125283e-01	0.040	0	0
Collagen chain trimerization	R-HSA-8948216	9.158586e-01	0.038	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.169032e-01	0.038	0	0
Kidney development	R-HSA-9830369	9.182480e-01	0.037	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	9.194477e-01	0.036	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.194477e-01	0.036	0	0
Attachment and Entry	R-HSA-9694614	9.194477e-01	0.036	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.218386e-01	0.035	0	0
Elastic fibre formation	R-HSA-1566948	9.219620e-01	0.035	0	0
Purine salvage	R-HSA-74217	9.219620e-01	0.035	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	9.266285e-01	0.033	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	9.266285e-01	0.033	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.266285e-01	0.033	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.266285e-01	0.033	0	0
Cardiac conduction	R-HSA-5576891	9.291836e-01	0.032	0	0
Paracetamol ADME	R-HSA-9753281	9.324569e-01	0.030	0	0
Interleukin-2 family signaling	R-HSA-451927	9.329381e-01	0.030	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.329381e-01	0.030	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.331696e-01	0.030	0	0
Interleukin-20 family signaling	R-HSA-8854691	9.331696e-01	0.030	0	0
Interleukin receptor SHC signaling	R-HSA-912526	9.331696e-01	0.030	0	0
Formation of the ureteric bud	R-HSA-9830674	9.331696e-01	0.030	0	0
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.331696e-01	0.030	0	0
Mitochondrial mRNA modification	R-HSA-9937008	9.331696e-01	0.030	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.378617e-01	0.028	0	0
Maturation of spike protein	R-HSA-9694548	9.378617e-01	0.028	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.391280e-01	0.027	0	0
Complex III assembly	R-HSA-9865881	9.391280e-01	0.027	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.399166e-01	0.027	0	0
Ca2+ pathway	R-HSA-4086398	9.432097e-01	0.025	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.445554e-01	0.025	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.445554e-01	0.025	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.445554e-01	0.025	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.445554e-01	0.025	0	0
Laminin interactions	R-HSA-3000157	9.445554e-01	0.025	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.448231e-01	0.025	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.448231e-01	0.025	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.484540e-01	0.023	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.494992e-01	0.023	0	0
Linoleic acid (LA) metabolism	R-HSA-2046105	9.494992e-01	0.023	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.494992e-01	0.023	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.498406e-01	0.022	0	0
PI Metabolism	R-HSA-1483255	9.511365e-01	0.022	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.516410e-01	0.022	0	0
Metabolism of polyamines	R-HSA-351202	9.518614e-01	0.021	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.540024e-01	0.020	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.540024e-01	0.020	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	9.540024e-01	0.020	0	0
Triglyceride biosynthesis	R-HSA-75109	9.540024e-01	0.020	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.540024e-01	0.020	0	0
Maturation of hRSV A proteins	R-HSA-9828806	9.540024e-01	0.020	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.541329e-01	0.020	0	0
Amine ligand-binding receptors	R-HSA-375280	9.543281e-01	0.020	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.543281e-01	0.020	0	0
Collagen degradation	R-HSA-1442490	9.550575e-01	0.020	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.555513e-01	0.020	0	0
Leishmania phagocytosis	R-HSA-9664417	9.555513e-01	0.020	0	0
Parasite infection	R-HSA-9664407	9.555513e-01	0.020	0	0
Neuronal System	R-HSA-112316	9.568428e-01	0.019	0	0
SLC transporter disorders	R-HSA-5619102	9.570834e-01	0.019	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.577399e-01	0.019	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.577399e-01	0.019	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.581044e-01	0.019	0	0
Insulin receptor recycling	R-HSA-77387	9.581044e-01	0.019	0	0
Pyrimidine salvage	R-HSA-73614	9.581044e-01	0.019	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.606534e-01	0.017	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.609067e-01	0.017	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.609067e-01	0.017	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	9.618407e-01	0.017	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.648164e-01	0.016	0	0
DAP12 signaling	R-HSA-2424491	9.652441e-01	0.015	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	9.652441e-01	0.015	0	0
GPER1 signaling	R-HSA-9634597	9.665705e-01	0.015	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.675702e-01	0.014	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.690976e-01	0.014	0	0
Extracellular matrix organization	R-HSA-1474244	9.701169e-01	0.013	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.704217e-01	0.013	0	0
Azathioprine ADME	R-HSA-9748787	9.714401e-01	0.013	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	9.737396e-01	0.012	0	0
Recycling of bile acids and salts	R-HSA-159418	9.737396e-01	0.012	0	0
Regulation of insulin secretion	R-HSA-422356	9.739929e-01	0.011	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.760823e-01	0.011	0	0
Miscellaneous transport and binding events	R-HSA-5223345	9.760823e-01	0.011	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.774837e-01	0.010	0	0
ECM proteoglycans	R-HSA-3000178	9.777409e-01	0.010	0	0
Metabolism of porphyrins	R-HSA-189445	9.777409e-01	0.010	0	0
Metabolism of cofactors	R-HSA-8978934	9.777409e-01	0.010	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.782161e-01	0.010	0	0
RA biosynthesis pathway	R-HSA-5365859	9.782161e-01	0.010	0	0
Signal amplification	R-HSA-392518	9.782161e-01	0.010	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.801596e-01	0.009	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.801596e-01	0.009	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.801596e-01	0.009	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.801596e-01	0.009	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.801596e-01	0.009	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.819299e-01	0.008	0	0
Triglyceride catabolism	R-HSA-163560	9.819299e-01	0.008	0	0
Lysine catabolism	R-HSA-71064	9.835423e-01	0.007	0	0
Synthesis of PA	R-HSA-1483166	9.836466e-01	0.007	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.842341e-01	0.007	0	0
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.850109e-01	0.007	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.855732e-01	0.006	0	0
Triglyceride metabolism	R-HSA-8979227	9.860785e-01	0.006	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.863485e-01	0.006	0	0
Pentose phosphate pathway	R-HSA-71336	9.863485e-01	0.006	0	0
Collagen formation	R-HSA-1474290	9.872858e-01	0.006	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.875669e-01	0.005	0	0
Tryptophan catabolism	R-HSA-71240	9.875669e-01	0.005	0	0
Nucleotide salvage	R-HSA-8956321	9.881569e-01	0.005	0	0
Aquaporin-mediated transport	R-HSA-445717	9.881569e-01	0.005	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.896872e-01	0.005	0	0
HIV Transcription Initiation	R-HSA-167161	9.896872e-01	0.005	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.896872e-01	0.005	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.896872e-01	0.005	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.896872e-01	0.005	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.906078e-01	0.004	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.907187e-01	0.004	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	9.914462e-01	0.004	0	0
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.914462e-01	0.004	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.914463e-01	0.004	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.919679e-01	0.004	0	0
DAP12 interactions	R-HSA-2172127	9.922098e-01	0.003	0	0
Surfactant metabolism	R-HSA-5683826	9.922098e-01	0.003	0	0
Methylation	R-HSA-156581	9.922098e-01	0.003	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.922098e-01	0.003	0	0
Innate Immune System	R-HSA-168249	9.923492e-01	0.003	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.929053e-01	0.003	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.931144e-01	0.003	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.933081e-01	0.003	0	0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.941157e-01	0.003	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.943226e-01	0.002	0	0
Metabolism of proteins	R-HSA-392499	9.949592e-01	0.002	0	0
Leishmania infection	R-HSA-9658195	9.950412e-01	0.002	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.950412e-01	0.002	0	0
Integration of energy metabolism	R-HSA-163685	9.955022e-01	0.002	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.955555e-01	0.002	0	0
Aspirin ADME	R-HSA-9749641	9.955678e-01	0.002	0	0
Formation of the cornified envelope	R-HSA-6809371	9.959857e-01	0.002	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.963797e-01	0.002	0	0
PPARA activates gene expression	R-HSA-1989781	9.964416e-01	0.002	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.965157e-01	0.002	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	9.970735e-01	0.001	0	0
Interleukin-10 signaling	R-HSA-6783783	9.970735e-01	0.001	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.978030e-01	0.001	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.982565e-01	0.001	0	0
Endogenous sterols	R-HSA-211976	9.984123e-01	0.001	0	0
Complex I biogenesis	R-HSA-6799198	9.986834e-01	0.001	0	0
Xenobiotics	R-HSA-211981	9.988011e-01	0.001	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.990943e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.990947e-01	0.000	0	0
Nicotinate metabolism	R-HSA-196807	9.990947e-01	0.000	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.993165e-01	0.000	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.993776e-01	0.000	0	0
Retinoid metabolism and transport	R-HSA-975634	9.993776e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.993853e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.995785e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.996698e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.996698e-01	0.000	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.997059e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.997561e-01	0.000	0	0
G alpha (q) signalling events	R-HSA-416476	9.997897e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.998159e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.998484e-01	0.000	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.998844e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	9.999000e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999045e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.999208e-01	0.000	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999250e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999250e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999344e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999456e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999549e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999621e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999626e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999678e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999766e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999784e-01	0.000	0	0
G alpha (s) signalling events	R-HSA-418555	9.999792e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999793e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999876e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999878e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999879e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999898e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999900e-01	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	9.999903e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999916e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999936e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999951e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999955e-01	0.000	0	0
Drug ADME	R-HSA-9748784	9.999975e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999984e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999989e-01	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999995e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999995e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.999997e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.999998e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999998e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999999e-01	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	9.999999e-01	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999999e-01	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0