CLK1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A2RRP1	S473	Sugiyama	NBAS NAG	APKRSRLETRAGEEDEGEEDsDsDyEISAKARYFGYIKQGL
A2RRP1	S475	Sugiyama	NBAS NAG	KRSRLETRAGEEDEGEEDsDsDyEISAKARYFGYIKQGLYL
O00165	S153	Sugiyama	HAX1 HS1BP1	PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14980	S1055	Sugiyama	XPO1 CRM1	LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15047	S470	Sugiyama	SETD1A KIAA0339 KMT2F SET1 SET1A	sPEREEVRtsPRPAsPARsGsPAPEttNESVPFAQHSSLDS
O15061	S1044	Sugiyama	SYNM DMN KIAA0353 SYN	ASEMEKAVESVVREsLsRQRsPAPGsPDEEGGAEAPAAGIR
O60927	S77	Sugiyama	PPP1R11 HCGV TCTE5	ssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHRKG
O60927	T75	Sugiyama	PPP1R11 HCGV TCTE5	RRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHR
O95394	S64	Sugiyama	PGM3 AGM1	LLAVLRSKQTKSTIGVMVtAsHNPEEDNGVKLVDPLGEMLA
P00338	Y239	Sugiyama	LDHA PIG19	GtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVADL
P00491	S176	Sugiyama	PNP NP	GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00519	T735	SIGNOR\|EPSD\|PSP	ABL1 ABL JTK7	RsCsAsCVPHGAKDTEWRSVtLPRDLQStGRQFDSstFGGH
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05187	S114	Sugiyama	ALPP PLAP	DRFPYVALSKTYNVDKHVPDsGAtATAYLCGVKGNFQTIGL
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P06744	T109	Sugiyama	GPI	KINyTEGRAVLHVALRNRsNtPILVDGKDVMPEVNKVLDKM
P07195	S320	Sugiyama	LDHB	GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07951	S271	Sugiyama	TPM2 TMSB	KtIDDLEDEVyAQKMKYKAIsEELDNALNDItsL_______
P08195	S607	Sugiyama	SLC3A2 MDU1	ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	Y457	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P08621	S226	GPS6\|PSP	SNRNP70 RNPU1Z RPU1 SNRP70 U1AP1	VNIRHSGRDDtsRyDERPGPsPLPHRDRDRDRERERRERSR
P08708	S89	Sugiyama	RPS17 RPS17L	ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09923	S111	Sugiyama	ALPI	DRFPYLALSKTYNVDRQVPDsAATATAYLCGVKANFQTIGL
P10696	S111	Sugiyama	ALPG ALPPL ALPPL2	DRFPYVALSKTYSVDKHVPDsGAtATAYLCGVKGNFQTIGL
P10809	S70	Sugiyama	HSPD1 HSP60	AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142	T37	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311	S539	Sugiyama	EZR VIL2	TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P16949	S38	Sugiyama	STMN1 C1orf215 LAP18 OP18	QAFELILsPRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAE
P17812	S573	Sugiyama	CTPS1 CTPS	HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P18031	S242	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	PTPN1 PTP1B	SGTFCLADTCLLLMDKRKDPssVDIKKVLLEMRKFRMGLIQ
P18031	S243	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	PTPN1 PTP1B	GTFCLADTCLLLMDKRKDPssVDIKKVLLEMRKFRMGLIQT
P18031	S50	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PTPN1 PTP1B	FPCRVAKLPKNKNRNRyRDVsPFDHSRIKLHQEDNDyINAs
P18615	S115	Sugiyama	NELFE RD RDBP	KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P18669	S14	Sugiyama	PGAM1 PGAMA CDABP0006	_______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P18754	S11	Sugiyama	RCC1 CHC1	__________MsPKRIAKRRsPPADAIPKsKKVKVsHRsHs
P18858	T183	Sugiyama	LIG1	sLTEAEVAtEKEGEDGDQPttPPKPLKTSKAEtPtEsVsEP
P19338	S580	Sugiyama	NCL	PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P22059	S193	Sugiyama	OSBP OSBP1	VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27348	T30	Sugiyama	YWHAQ	AKLAEQAERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKN
P29692	S162	Sugiyama	EEF1D EF1D	AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P34931	T39	Sugiyama	HSPA1L	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P35221	S641	Sugiyama	CTNNA1	GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P35579	S1916	Sugiyama	MYH9	LQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMAR
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T86	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38646	T87	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P42166	S159	Sugiyama	TMPO LAP2	RKLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsND
P42167	S159	Sugiyama	TMPO LAP2	RKLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSND
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243	S195	Sugiyama	MATR3 KIAA0723	RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46937	T114	Sugiyama	YAP1 YAP65	sFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQL
P49759	S140	Sugiyama	CLK1 CLK	HHSTSHRRSHGKSHRRKRtRsVEDDEEGHLICQSGDVLSAR
P49759	S337	Sugiyama	CLK1 CLK	INPDIKVVDFGsATyDDEHHstLVstRHyRAPEVILALGWS
P49759	S341	Sugiyama	CLK1 CLK	IKVVDFGsATyDDEHHstLVstRHyRAPEVILALGWSQPCD
P49759	T315	Sugiyama	CLK1 CLK	LFVQSDYTEAYNPKIKRDERtLINPDIKVVDFGsATyDDEH
P49759	T338	Sugiyama	CLK1 CLK	NPDIKVVDFGsATyDDEHHstLVstRHyRAPEVILALGWSQ
P49759	T342	Sugiyama	CLK1 CLK	KVVDFGsATyDDEHHstLVstRHyRAPEVILALGWSQPCDV
P49759	Y345	Sugiyama	CLK1 CLK	DFGsATyDDEHHstLVstRHyRAPEVILALGWSQPCDVWSI
P49840	Y279	Sugiyama	GSK3A	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841	Y216	Sugiyama	GSK3B	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P51858	S165	Sugiyama	HDGF HMG1L2	AKEKNEKGALKRRAGDLLEDsPKRPKEAENPEGEEKEAAtL
P52742	S308	Sugiyama	ZNF135 ZNF61 ZNF78L1	HQRTHTGEKPYECSECGKSFsFRSSFSQHERTHTGEKPYEC
P54652	T38	Sugiyama	HSPA2	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P55081	S132	Sugiyama	MFAP1	VVGEsDsEVEGDAWRMEREDssEEEEEEIDDEEIERRRGMM
P60709	T318	Sugiyama	ACTB	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P61247	S263	Sugiyama	RPS3A FTE1 MFTL	GDEtGAKVERADGyEPPVQEsV___________________
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736	T320	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62750	T42	Sugiyama	RPL23A	LKAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPR
P62899	S15	Sugiyama	RPL31	______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62917	S14	Sugiyama	RPL8	_______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261	T318	Sugiyama	ACTG1 ACTG	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63267	T319	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P67809	S209	Sugiyama	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68032	T320	Sugiyama	ACTC1 ACTC	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133	T320	Sugiyama	ACTA1 ACTA	VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P78345	S253	Sugiyama	RPP38	DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
Q00839	S267	Sugiyama	HNRNPU C1orf199 HNRPU SAFA U21.1	KRPREDHGRGyFEyIEENKysRAKsPQPPVEEEDEHFDDtV
Q07021	S210	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q07666	S20	Sugiyama	KHDRBS1 SAM68	_MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q12968	S161	Sugiyama	NFATC3 NFAT4	LERPSRDHLyLPLEPSYRESsLsPsPASSISSRSWFsDAss
Q13112	S410	Sugiyama	CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7	LNMRtPDtAKKTKsQtHRGssPGPRPVEGtPASRtQDPssP
Q13242	S211	Sugiyama	SRSF9 SFRS9 SRP30C	GYsRsRSGsRGRDsPyQsRGsPHyFsPFRPy__________
Q13247	S303	Sugiyama	SRSF6 SFRS6 SRP55	ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13263	S138	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	PVCKQQCFSKDIVENyFMRDsGsKAATDAQDANQCCTSCED
Q13283	S231	Sugiyama	G3BP1 G3BP	QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13285	S203	PSP	NR5A1 AD4BP FTZF1 SF1	YLYPAFPGRAIKSEYPEPYAsPPQPGLPYGYPEPFSGGPNV
Q14155	S518	Sugiyama	ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314	ERYLLLFPNVLLMLSASPRMsGFIyQGKLPtTGMTITKLED
Q15052	S488	Sugiyama	ARHGEF6 COOL2 KIAA0006 PIXA	ERYLMLFSNVLIMLSASPRMsGFIYQGKIPIAGTVVTRLDE
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q16513	T958	Sugiyama	PKN2 PRK2 PRKCL2	RGREDVSNFDDEFtsEAPILtPPREPRILsEEEQEMFRDFD
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q6PCE3	S175	Sugiyama	PGM2L1 BM32A	PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6PKG0	S627	Sugiyama	LARP1 KIAA0731 LARP	FLFDEEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVt
Q6UN15	S492	Sugiyama	FIP1L1 FIP1 RHE	DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15	T494	Sugiyama	FIP1L1 FIP1 RHE	DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q8IZ21	S118	Sugiyama	PHACTR4 PRO2963	PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q92974	S956	Sugiyama	ARHGEF2 KIAA0651 LFP40	RLQDssDPDtGsEEEGssRLsPPHsPRDFtRMQDIPEEtEs
Q96G46	S272	Sugiyama	DUS3L	EGAPRQENCGAQQVPAGPGtstPPssPVRtCGPLtDEDVVR
Q96G46	T273	Sugiyama	DUS3L	GAPRQENCGAQQVPAGPGtstPPssPVRtCGPLtDEDVVRL
Q96GM8	S420	Sugiyama	TOE1	KNDLEMGIKAARPEIADRATsEVPGsQAsPNPVPGDGLHRA
Q96I25	S202	SIGNOR\|EPSD\|PSP	RBM17 SPF45	VEKDKELPRDFPyEEDSRPRsQsSKAAIPPPVyEEQDRPRs
Q96I25	S204	SIGNOR\|EPSD\|PSP	RBM17 SPF45	KDKELPRDFPyEEDSRPRsQsSKAAIPPPVyEEQDRPRsPt
Q96I25	S222	SIGNOR\|EPSD\|PSP	RBM17 SPF45	sQsSKAAIPPPVyEEQDRPRsPtGPsNsFLANMGGTVAHKI
Q96I25	S266	SIGNOR\|EPSD\|PSP	RBM17 SPF45	YGFREGQGLGKHEQGLSTALsVEKTSKRGGKIIVGDATEKD
Q96I25	S288	SIGNOR\|EPSD\|PSP	RBM17 SPF45	EKTSKRGGKIIVGDATEKDAsKKsDsNPLTEILKCPTKVVL
Q96I25	S291	SIGNOR\|EPSD\|PSP	RBM17 SPF45	SKRGGKIIVGDATEKDAsKKsDsNPLTEILKCPTKVVLLRN
Q96I25	S48	SIGNOR\|EPSD\|PSP	RBM17 SPF45	sQLQVKKAALTQAKSQRTKQsTVLAPVIDLKRGGssDDRQI
Q96I25	S62	SIGNOR\|EPSD\|PSP	RBM17 SPF45	SQRTKQsTVLAPVIDLKRGGssDDRQIVDtPPHVAAGLKDP
Q96MH2	S76	Sugiyama	HEXIM2 L3	EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q96QK1	S786	Sugiyama	VPS35 MEM3 TCCCTA00141	INKHFHNtLEHLRLRREsPEsEGPIyEGLIL__________
Q96S44	T8	Sugiyama	TP53RK C20orf64 PRPK	_____________MAAARAttPADGEEPAPEAEALAAARER
Q9BQE3	S439	Sugiyama	TUBA1C TUBA6	SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BRS2	S507	Sugiyama	RIOK1 RIO1	ENQVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHTTDP
Q9BRS2	T509	Sugiyama	RIOK1 RIO1	QVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHTTDPDI
Q9BX95	S112	Sugiyama	SGPP1 SPP1	GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9C0C2	S672	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H7D7	S121	Sugiyama	WDR26 CDW2 MIP2 PRO0852	ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9H7D7	S123	Sugiyama	WDR26 CDW2 MIP2 PRO0852	SSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLNQT
Q9H7N4	S498	Sugiyama	SCAF1 SFRS19 SRA1	GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4	S500	Sugiyama	SCAF1 SFRS19 SRA1	LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9HAZ1	S335	Sugiyama	CLK4	KNTDIKVVDFGsATyDDEHHstLVstRHyRAPEVILALGWS
Q9HAZ1	S339	Sugiyama	CLK4	IKVVDFGsATyDDEHHstLVstRHyRAPEVILALGWSQPCD
Q9HAZ1	T336	Sugiyama	CLK4	NTDIKVVDFGsATyDDEHHstLVstRHyRAPEVILALGWSQ
Q9HAZ1	T340	Sugiyama	CLK4	KVVDFGsATyDDEHHstLVstRHyRAPEVILALGWSQPCDV
Q9HAZ1	Y343	Sugiyama	CLK4	DFGsATyDDEHHstLVstRHyRAPEVILALGWSQPCDVWSI
Q9HDC5	S413	Sugiyama	JPH1 JP1	QAALAARQECDIARAVARELsPDFyQPGPDyVKQRFQEGVD
Q9NPQ8	T441	Sugiyama	RIC8A	AARGLMAGGRPEGQysEDEDtDtDEyKEAKAsINPVTGRVE
Q9NR19	S30	Sugiyama	ACSS2 ACAS2	sGsGSRGQEEAGAGGRARsWsPPPEVsRSAHVPSLQRYREL
Q9NR28	S230	Sugiyama	DIABLO SMAC	EAQIEELRQKTQEEGEERAEsEQEAyLRED___________
Q9NYF8	S320	Sugiyama	BCLAF1 BTF KIAA0164	sPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRF
Q9P2T1	S37	Sugiyama	GMPR2	LRPKRSTLKsRsEVDLTRSFsFRNSKQTYSGVPIIAANMDT
Q9UJ70	S76	Sugiyama	NAGK	AKRKAGVDPLVPLRsLGLsLsGGDQEDAGRILIEELRDRFP
Q9UJY1	S24	Sugiyama	HSPB8 CRYAC E2IG1 HSP22 PP1629	GQMPFSCHYPsRLRRDPFRDsPLsSRLLDDGFGMDPFPDDL
Q9UPR0	T584	Sugiyama	PLCL2 KIAA1092 PLCE2	KILIKAKKLsSNCSGVEGDVtDEDEGAEMSQRMGKENMEQP
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S1648	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	S2692	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ35	S2694	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	RSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQSSs
Q9UQ35	S876	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	tsPQANEQsVtPQRRsCFEssPDPELKsRtPsRHsCsGssP
Q9Y2W1	S805	Sugiyama	THRAP3 BCLAF2 TRAP150	QSSHSYKAEEYTEEtEEREEstTGFDKSRLGTKDFVGPSER

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	2.853104e-10	9.545
Chromatin organization	R-HSA-4839726	2.151275e-09	8.667
Cell Cycle, Mitotic	R-HSA-69278	3.056092e-09	8.515
Chromatin modifying enzymes	R-HSA-3247509	6.491981e-09	8.188
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.273833e-07	6.278
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	7.652132e-07	6.116
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.660622e-06	5.575
M Phase	R-HSA-68886	2.623855e-06	5.581
NRAGE signals death through JNK	R-HSA-193648	4.334133e-06	5.363
G2/M Transition	R-HSA-69275	5.210512e-06	5.283
Mitotic G2-G2/M phases	R-HSA-453274	6.699645e-06	5.174
PKMTs methylate histone lysines	R-HSA-3214841	7.693299e-06	5.114
RNA Polymerase II Transcription Termination	R-HSA-73856	1.409550e-05	4.851
mRNA 3'-end processing	R-HSA-72187	1.623577e-05	4.790
Regulation of MECP2 expression and activity	R-HSA-9022692	2.555730e-05	4.592
Mitotic Prometaphase	R-HSA-68877	2.489125e-05	4.604
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.452264e-05	4.610
Polo-like kinase mediated events	R-HSA-156711	2.720221e-05	4.565
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.601065e-05	4.252
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.819049e-05	4.235
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	6.279667e-05	4.202
AURKA Activation by TPX2	R-HSA-8854518	1.103559e-04	3.957
Nuclear Envelope Breakdown	R-HSA-2980766	1.422702e-04	3.847
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.507296e-04	3.822
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.670505e-04	3.777
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.670505e-04	3.777
Centrosome maturation	R-HSA-380287	2.121576e-04	3.673
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	3.225051e-04	3.491
Apoptotic execution phase	R-HSA-75153	3.352048e-04	3.475
G alpha (12/13) signalling events	R-HSA-416482	3.456946e-04	3.461
Cell Cycle Checkpoints	R-HSA-69620	3.766693e-04	3.424
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	4.500428e-04	3.347
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.724285e-04	3.326
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	6.355572e-04	3.197
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	8.225788e-04	3.085
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	8.045786e-04	3.094
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.406091e-04	3.075
Mitotic Prophase	R-HSA-68875	8.969403e-04	3.047
RNA Polymerase II Transcription	R-HSA-73857	1.122528e-03	2.950
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.107756e-03	2.956
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.206615e-03	2.918
MECP2 regulates transcription factors	R-HSA-9022707	1.371716e-03	2.863
NGF-stimulated transcription	R-HSA-9031628	1.336993e-03	2.874
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.467480e-03	2.833
Gene expression (Transcription)	R-HSA-74160	1.443463e-03	2.841
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.687540e-03	2.773
Regulation of TP53 Activity	R-HSA-5633007	1.704598e-03	2.768
p75 NTR receptor-mediated signalling	R-HSA-193704	1.880676e-03	2.726
Transcriptional regulation by RUNX1	R-HSA-8878171	2.022112e-03	2.694
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	2.202318e-03	2.657
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.202318e-03	2.657
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.327914e-03	2.633
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.406290e-03	2.619
Amplification of signal from the kinetochores	R-HSA-141424	2.406290e-03	2.619
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.832598e-03	2.548
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.831081e-03	2.548
Mitotic Anaphase	R-HSA-68882	2.626440e-03	2.581
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.832598e-03	2.548
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.997412e-03	2.523
Death Receptor Signaling	R-HSA-73887	3.184212e-03	2.497
Estrogen-dependent gene expression	R-HSA-9018519	3.318635e-03	2.479
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	3.468982e-03	2.460
mRNA Splicing - Major Pathway	R-HSA-72163	3.532952e-03	2.452
HATs acetylate histones	R-HSA-3214847	3.773509e-03	2.423
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.916769e-03	2.407
Nuclear import of Rev protein	R-HSA-180746	4.186482e-03	2.378
Mitotic Spindle Checkpoint	R-HSA-69618	4.205898e-03	2.376
Signaling by NTRK1 (TRKA)	R-HSA-187037	4.339862e-03	2.363
mRNA Splicing	R-HSA-72172	4.851874e-03	2.314
Transcriptional Regulation by MECP2	R-HSA-8986944	4.899307e-03	2.310
Apoptosis induced DNA fragmentation	R-HSA-140342	4.932164e-03	2.307
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	5.035334e-03	2.298
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	5.035334e-03	2.298
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	5.513487e-03	2.259
Signaling by NTRKs	R-HSA-166520	5.856319e-03	2.232
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	5.969449e-03	2.224
Apoptotic cleavage of cellular proteins	R-HSA-111465	6.433419e-03	2.192
MITF-M-dependent gene expression	R-HSA-9856651	6.899241e-03	2.161
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	6.907214e-03	2.161
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.141923e-03	2.146
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	7.213279e-03	2.142
Cardiogenesis	R-HSA-9733709	7.718827e-03	2.112
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	7.718827e-03	2.112
Nuclear RNA decay	R-HSA-9930044	7.718827e-03	2.112
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	8.176220e-03	2.087
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	8.002263e-03	2.097
Formation of the anterior neural plate	R-HSA-9823739	8.176220e-03	2.087
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	8.126990e-03	2.090
Developmental Lineages of the Mammary Gland	R-HSA-9924644	8.249385e-03	2.084
Specification of the neural plate border	R-HSA-9834899	8.607436e-03	2.065
Mitotic Telophase/Cytokinesis	R-HSA-68884	9.577199e-03	2.019
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	1.009055e-02	1.996
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.009055e-02	1.996
NrCAM interactions	R-HSA-447038	1.009055e-02	1.996
Signal Transduction	R-HSA-162582	1.066388e-02	1.972
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.127492e-02	1.948
Interactions of Rev with host cellular proteins	R-HSA-177243	1.153415e-02	1.938
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.185577e-02	1.926
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.214137e-02	1.916
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.233783e-02	1.909
SWI/SNF chromatin remodelers	R-HSA-9932451	1.272842e-02	1.895
ATP-dependent chromatin remodelers	R-HSA-9932444	1.272842e-02	1.895
HDMs demethylate histones	R-HSA-3214842	1.272842e-02	1.895
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.407700e-02	1.851
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.407700e-02	1.851
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	1.485047e-02	1.828
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.571297e-02	1.804
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.571297e-02	1.804
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	1.571297e-02	1.804
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	1.671767e-02	1.777
Generic Transcription Pathway	R-HSA-212436	1.696910e-02	1.770
Specification of primordial germ cells	R-HSA-9827857	1.696261e-02	1.771
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.642859e-02	1.784
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.737143e-02	1.760
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.834175e-02	1.737
IPs transport between nucleus and cytosol	R-HSA-1855170	1.943252e-02	1.711
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.037090e-02	1.691
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.943252e-02	1.711
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.016613e-02	1.695
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.007191e-02	1.697
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.098568e-02	1.678
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.113625e-02	1.675
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.138935e-02	1.670
Transcriptional regulation of granulopoiesis	R-HSA-9616222	2.183497e-02	1.661
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.183497e-02	1.661
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.260931e-02	1.646
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.307005e-02	1.637
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	2.381868e-02	1.623
Formation of the posterior neural plate	R-HSA-9832991	2.659309e-02	1.575
Germ layer formation at gastrulation	R-HSA-9754189	2.562764e-02	1.591
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.533721e-02	1.596
PIP3 activates AKT signaling	R-HSA-1257604	2.438437e-02	1.613
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.638259e-02	1.579
Intracellular signaling by second messengers	R-HSA-9006925	2.765299e-02	1.558
Formation of RNA Pol II elongation complex	R-HSA-112382	2.889713e-02	1.539
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.913090e-02	1.536
Signaling by ALK in cancer	R-HSA-9700206	2.913090e-02	1.536
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.092583e-02	1.510
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.002561e-02	1.523
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.230248e-02	1.491
Meiotic synapsis	R-HSA-1221632	3.230248e-02	1.491
Metabolism of non-coding RNA	R-HSA-194441	3.116424e-02	1.506
snRNP Assembly	R-HSA-191859	3.116424e-02	1.506
Formation of definitive endoderm	R-HSA-9823730	3.092583e-02	1.510
MITF-M-regulated melanocyte development	R-HSA-9730414	3.201931e-02	1.495
Interleukin-37 signaling	R-HSA-9008059	2.952791e-02	1.530
Activation of RAC1	R-HSA-428540	3.419493e-02	1.466
Kinesins	R-HSA-983189	3.456143e-02	1.461
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	3.508531e-02	1.455
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	3.508531e-02	1.455
Transcriptional activation of p53 responsive genes	R-HSA-69560	3.508531e-02	1.455
ESR-mediated signaling	R-HSA-8939211	3.587241e-02	1.445
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.593666e-02	1.444
HDACs deacetylate histones	R-HSA-3214815	3.996428e-02	1.398
ISG15 antiviral mechanism	R-HSA-1169408	4.150772e-02	1.382
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	4.214249e-02	1.375
Transcriptional Regulation by TP53	R-HSA-3700989	4.228818e-02	1.374
Type I hemidesmosome assembly	R-HSA-446107	4.282778e-02	1.368
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.301689e-02	1.366
Separation of Sister Chromatids	R-HSA-2467813	4.628448e-02	1.335
Axon guidance	R-HSA-422475	4.691239e-02	1.329
Gastrulation	R-HSA-9758941	4.448778e-02	1.352
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	4.882679e-02	1.311
Transport of glycerol from adipocytes to the liver by Aquaporins	R-HSA-432030	4.963921e-02	1.304
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	4.963921e-02	1.304
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.985381e-02	1.302
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.118542e-02	1.291
Formation of axial mesoderm	R-HSA-9796292	5.308565e-02	1.275
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.308565e-02	1.275
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	5.308565e-02	1.275
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.373025e-02	1.270
G2/M Checkpoints	R-HSA-69481	5.497927e-02	1.260
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	5.546518e-02	1.256
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	5.546518e-02	1.256
AKT phosphorylates targets in the nucleus	R-HSA-198693	5.546518e-02	1.256
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	5.546518e-02	1.256
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.702269e-02	1.244
Transcriptional regulation by small RNAs	R-HSA-5578749	5.702269e-02	1.244
Regulation of KIT signaling	R-HSA-1433559	6.440968e-02	1.191
RAF activation	R-HSA-5673000	5.776953e-02	1.238
Cilium Assembly	R-HSA-5617833	6.094619e-02	1.215
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.990351e-02	1.223
Depolymerization of the Nuclear Lamina	R-HSA-4419969	5.771270e-02	1.239
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.440968e-02	1.191
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	6.704618e-02	1.174
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	6.821148e-02	1.166
Deadenylation of mRNA	R-HSA-429947	6.821148e-02	1.166
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	6.821148e-02	1.166
Neurodegenerative Diseases	R-HSA-8863678	6.821148e-02	1.166
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	7.023574e-02	1.153
Phosphorylation of Emi1	R-HSA-176417	7.023574e-02	1.153
Regulation of CDH19 Expression and Function	R-HSA-9764302	7.023574e-02	1.153
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	8.180425e-02	1.087
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	8.180425e-02	1.087
Regulation of cortical dendrite branching	R-HSA-8985801	8.180425e-02	1.087
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	8.180425e-02	1.087
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	8.180425e-02	1.087
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	8.180425e-02	1.087
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	8.180425e-02	1.087
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	8.180425e-02	1.087
Potassium transport channels	R-HSA-1296067	8.180425e-02	1.087
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	8.180425e-02	1.087
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	8.180425e-02	1.087
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	8.180425e-02	1.087
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	8.180425e-02	1.087
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	8.180425e-02	1.087
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	8.180425e-02	1.087
DCC mediated attractive signaling	R-HSA-418885	7.698008e-02	1.114
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	7.773714e-02	1.109
Signaling by ROBO receptors	R-HSA-376176	7.943391e-02	1.100
TGFBR3 expression	R-HSA-9839394	7.793821e-02	1.108
Epigenetic regulation of gene expression	R-HSA-212165	7.906899e-02	1.102
Sema4D in semaphorin signaling	R-HSA-400685	7.793821e-02	1.108
Regulation of TP53 Expression	R-HSA-6804754	8.180425e-02	1.087
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	7.878274e-02	1.104
Long-term potentiation	R-HSA-9620244	7.793821e-02	1.108
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	7.265816e-02	1.139
Deubiquitination	R-HSA-5688426	8.064852e-02	1.093
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	8.187322e-02	1.087
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.500223e-02	1.071
Diseases of mitotic cell cycle	R-HSA-9675126	8.500223e-02	1.071
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	8.500223e-02	1.071
Regulation of NFE2L2 gene expression	R-HSA-9818749	9.198386e-02	1.036
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	9.198386e-02	1.036
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	9.198386e-02	1.036
G2/M DNA replication checkpoint	R-HSA-69478	9.198386e-02	1.036
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	9.077173e-02	1.042
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.843047e-02	1.053
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	9.929473e-02	1.003
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	8.989397e-02	1.046
Oncogenic MAPK signaling	R-HSA-6802957	9.056032e-02	1.043
Netrin-1 signaling	R-HSA-373752	9.322712e-02	1.030
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	8.843047e-02	1.053
Activation of ATR in response to replication stress	R-HSA-176187	9.493942e-02	1.023
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	9.493942e-02	1.023
S Phase	R-HSA-69242	9.357517e-02	1.029
Nervous system development	R-HSA-9675108	8.739174e-02	1.059
TRP channels	R-HSA-3295583	8.843047e-02	1.053
Apoptosis	R-HSA-109581	8.993336e-02	1.046
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	9.968020e-02	1.001
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	9.968020e-02	1.001
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	9.968020e-02	1.001
Drug resistance of KIT mutants	R-HSA-9669937	1.112987e-01	0.954
KIT mutants bind TKIs	R-HSA-9669921	1.112987e-01	0.954
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.112987e-01	0.954
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.112987e-01	0.954
Masitinib-resistant KIT mutants	R-HSA-9669924	1.112987e-01	0.954
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.112987e-01	0.954
Imatinib-resistant KIT mutants	R-HSA-9669917	1.112987e-01	0.954
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.112987e-01	0.954
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.112987e-01	0.954
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.112987e-01	0.954
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.112987e-01	0.954
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	1.185831e-01	0.926
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.185831e-01	0.926
Invadopodia formation	R-HSA-8941237	1.185831e-01	0.926
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.161299e-01	0.935
SOS-mediated signalling	R-HSA-112412	1.161299e-01	0.935
Cohesin Loading onto Chromatin	R-HSA-2470946	1.161299e-01	0.935
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.161299e-01	0.935
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.057448e-01	0.976
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.036173e-01	0.985
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.036173e-01	0.985
HIV elongation arrest and recovery	R-HSA-167287	1.116737e-01	0.952
Pausing and recovery of HIV elongation	R-HSA-167290	1.116737e-01	0.952
HIV Transcription Elongation	R-HSA-167169	1.092384e-01	0.962
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.092384e-01	0.962
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.092384e-01	0.962
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.021269e-01	0.991
Nucleosome assembly	R-HSA-774815	1.021269e-01	0.991
mRNA Splicing - Minor Pathway	R-HSA-72165	1.115022e-01	0.953
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.047642e-01	0.980
Passive transport by Aquaporins	R-HSA-432047	1.057448e-01	0.976
DNA Double-Strand Break Repair	R-HSA-5693532	1.190230e-01	0.924
Late Phase of HIV Life Cycle	R-HSA-162599	1.003608e-01	0.998
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.035399e-01	0.985
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.036173e-01	0.985
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.021269e-01	0.991
G2/M DNA damage checkpoint	R-HSA-69473	1.124667e-01	0.949
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.161299e-01	0.935
Signaling by PDGFR in disease	R-HSA-9671555	1.036173e-01	0.985
FLT3 Signaling	R-HSA-9607240	1.197173e-01	0.922
Glycolysis	R-HSA-70171	1.141790e-01	0.942
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.115022e-01	0.953
Metabolism of RNA	R-HSA-8953854	1.208347e-01	0.918
Transcription of the HIV genome	R-HSA-167172	1.213417e-01	0.916
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.218124e-01	0.914
Signaling by Hippo	R-HSA-2028269	1.218463e-01	0.914
Viral Messenger RNA Synthesis	R-HSA-168325	1.219300e-01	0.914
RUNX3 regulates p14-ARF	R-HSA-8951936	1.231333e-01	0.910
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.231333e-01	0.910
Disorders of Nervous System Development	R-HSA-9697154	1.231333e-01	0.910
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.231333e-01	0.910
Pervasive developmental disorders	R-HSA-9005895	1.231333e-01	0.910
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.231333e-01	0.910
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.231333e-01	0.910
Regulation of endogenous retroelements	R-HSA-9842860	1.279877e-01	0.893
Signaling by NOTCH3	R-HSA-9012852	1.316869e-01	0.880
Diseases of Telomere Maintenance	R-HSA-9673013	2.102158e-01	0.677
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.102158e-01	0.677
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.102158e-01	0.677
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.102158e-01	0.677
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.102158e-01	0.677
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.102158e-01	0.677
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.102158e-01	0.677
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.585516e-01	0.800
Regulation of gap junction activity	R-HSA-191650	1.585516e-01	0.800
HCN channels	R-HSA-1296061	1.585516e-01	0.800
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.585516e-01	0.800
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.585516e-01	0.800
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.585516e-01	0.800
PI and PC transport between ER and Golgi membranes	R-HSA-1483196	2.981280e-01	0.526
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	2.981280e-01	0.526
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	2.981280e-01	0.526
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	2.981280e-01	0.526
Interactions of Tat with host cellular proteins	R-HSA-176034	2.981280e-01	0.526
MyD88 deficiency (TLR5)	R-HSA-5602680	2.981280e-01	0.526
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.981280e-01	0.526
Signaling by kinase domain mutants of KIT	R-HSA-9669933	2.981280e-01	0.526
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.981280e-01	0.526
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	2.981280e-01	0.526
XAV939 stabilizes AXIN	R-HSA-5545619	2.981280e-01	0.526
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	2.981280e-01	0.526
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	2.981280e-01	0.526
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.981280e-01	0.526
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	2.981280e-01	0.526
Intestinal infectious diseases	R-HSA-8942233	2.981280e-01	0.526
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.981280e-01	0.526
Signaling by TCF7L2 mutants	R-HSA-5339700	2.981280e-01	0.526
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.981280e-01	0.526
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	2.005448e-01	0.698
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.005448e-01	0.698
IRS activation	R-HSA-74713	2.005448e-01	0.698
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.005448e-01	0.698
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.005448e-01	0.698
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	2.005448e-01	0.698
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	1.423478e-01	0.847
ROBO receptors bind AKAP5	R-HSA-9010642	1.423478e-01	0.847
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	1.423478e-01	0.847
Signaling by MRAS-complex mutants	R-HSA-9660537	1.423478e-01	0.847
Regulation of NPAS4 mRNA translation	R-HSA-9768778	1.423478e-01	0.847
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.423478e-01	0.847
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.436177e-01	0.613
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.436177e-01	0.613
Signalling to p38 via RIT and RIN	R-HSA-187706	2.436177e-01	0.613
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.436177e-01	0.613
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.436177e-01	0.613
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.762592e-01	0.425
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.762592e-01	0.425
TWIK related potassium channel (TREK)	R-HSA-1299503	3.762592e-01	0.425
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	3.762592e-01	0.425
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.438364e-01	0.842
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.438364e-01	0.842
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.996557e-01	0.700
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.996557e-01	0.700
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	1.996557e-01	0.700
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.657901e-01	0.780
CREB phosphorylation	R-HSA-199920	2.870102e-01	0.542
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	2.870102e-01	0.542
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.390118e-01	0.857
Ephrin signaling	R-HSA-3928664	1.390118e-01	0.857
ChREBP activates metabolic gene expression	R-HSA-163765	2.300881e-01	0.638
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	2.300881e-01	0.638
Signaling by APC mutants	R-HSA-4839744	2.300881e-01	0.638
Presynaptic depolarization and calcium channel opening	R-HSA-112308	2.300881e-01	0.638
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.300881e-01	0.638
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.300881e-01	0.638
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.300881e-01	0.638
Beta-catenin phosphorylation cascade	R-HSA-196299	1.888427e-01	0.724
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.571677e-01	0.804
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.762321e-01	0.754
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	2.128374e-01	0.672
Differentiation of T cells	R-HSA-9945266	2.128374e-01	0.672
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.128374e-01	0.672
Signaling by GSK3beta mutants	R-HSA-5339716	2.612926e-01	0.583
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	3.301179e-01	0.481
RUNX3 regulates WNT signaling	R-HSA-8951430	3.301179e-01	0.481
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.301179e-01	0.481
Netrin mediated repulsion signals	R-HSA-418886	3.301179e-01	0.481
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.301179e-01	0.481
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	3.301179e-01	0.481
DAG1 core M1 glycosylations	R-HSA-8932506	3.301179e-01	0.481
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	3.301179e-01	0.481
Activation of BIM and translocation to mitochondria	R-HSA-111446	4.456970e-01	0.351
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.456970e-01	0.351
Defective GSS causes GSS deficiency	R-HSA-5579006	4.456970e-01	0.351
Defective GCLC causes HAGGSD	R-HSA-5578999	4.456970e-01	0.351
MET activates PTPN11	R-HSA-8865999	4.456970e-01	0.351
IRAK4 deficiency (TLR5)	R-HSA-5603037	4.456970e-01	0.351
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.378105e-01	0.861
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.961173e-01	0.707
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.376163e-01	0.624
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.929847e-01	0.533
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.929847e-01	0.533
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.929847e-01	0.533
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.929847e-01	0.533
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.929847e-01	0.533
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.929847e-01	0.533
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.983092e-01	0.703
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.630225e-01	0.580
DAG1 core M2 glycosylations	R-HSA-8932504	3.724669e-01	0.429
MET receptor recycling	R-HSA-8875656	3.724669e-01	0.429
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.422370e-01	0.847
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.165331e-01	0.664
Formation of the Early Elongation Complex	R-HSA-113418	2.165331e-01	0.664
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.978552e-01	0.704
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.352970e-01	0.628
Condensation of Prophase Chromosomes	R-HSA-2299718	1.930740e-01	0.714
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.545358e-01	0.594
Activation of the pre-replicative complex	R-HSA-68962	2.545358e-01	0.594
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.545358e-01	0.594
ARMS-mediated activation	R-HSA-170984	4.136922e-01	0.383
Inactivation of CDC42 and RAC1	R-HSA-428543	4.136922e-01	0.383
ALK mutants bind TKIs	R-HSA-9700645	4.136922e-01	0.383
TNFR1-mediated ceramide production	R-HSA-5626978	5.074083e-01	0.295
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	5.074083e-01	0.295
AKT-mediated inactivation of FOXO1A	R-HSA-211163	5.074083e-01	0.295
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.074083e-01	0.295
Signaling by MAP2K mutants	R-HSA-9652169	5.074083e-01	0.295
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.074083e-01	0.295
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	5.074083e-01	0.295
Nuclear Receptor transcription pathway	R-HSA-383280	1.459196e-01	0.836
PRC2 methylates histones and DNA	R-HSA-212300	2.484702e-01	0.605
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.860207e-01	0.730
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	3.885150e-01	0.411
ERBB2 Regulates Cell Motility	R-HSA-6785631	3.885150e-01	0.411
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.273921e-01	0.485
Assembly of the ORC complex at the origin of replication	R-HSA-68616	3.144377e-01	0.502
Packaging Of Telomere Ends	R-HSA-171306	3.503811e-01	0.455
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.489123e-01	0.604
Striated Muscle Contraction	R-HSA-390522	3.349129e-01	0.475
Phosphorylation of the APC/C	R-HSA-176412	4.198151e-01	0.377
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	3.210302e-01	0.493
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.210302e-01	0.493
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.967823e-01	0.528
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.555339e-01	0.449
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.586000e-01	0.445
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	3.586000e-01	0.445
HIV Transcription Initiation	R-HSA-167161	3.586000e-01	0.445
RNA Polymerase II Transcription Initiation	R-HSA-75953	3.586000e-01	0.445
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.965053e-01	0.402
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	4.505598e-01	0.346
GRB2 events in ERBB2 signaling	R-HSA-1963640	4.505598e-01	0.346
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	4.505598e-01	0.346
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	4.505598e-01	0.346
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	4.917486e-01	0.308
DAG1 core M3 glycosylations	R-HSA-8932505	4.917486e-01	0.308
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	5.622523e-01	0.250
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.622523e-01	0.250
RNA Polymerase II Promoter Escape	R-HSA-73776	3.965144e-01	0.402
PI3K events in ERBB2 signaling	R-HSA-1963642	4.806153e-01	0.318
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.720200e-01	0.326
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.282425e-01	0.277
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.282425e-01	0.277
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.282425e-01	0.277
ERKs are inactivated	R-HSA-202670	5.282425e-01	0.277
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	5.282425e-01	0.277
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	4.344097e-01	0.362
GAB1 signalosome	R-HSA-180292	5.098696e-01	0.293
Translation initiation complex formation	R-HSA-72649	4.482640e-01	0.348
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	4.394161e-01	0.357
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	5.382315e-01	0.269
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.629136e-01	0.250
Repression of WNT target genes	R-HSA-4641265	5.629136e-01	0.250
GRB2 events in EGFR signaling	R-HSA-179812	5.629136e-01	0.250
PDE3B signalling	R-HSA-165160	6.109930e-01	0.214
PKB-mediated events	R-HSA-109703	6.109930e-01	0.214
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.109930e-01	0.214
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.109930e-01	0.214
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.109930e-01	0.214
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.109930e-01	0.214
Signaling by MAPK mutants	R-HSA-9652817	6.109930e-01	0.214
EPHA-mediated growth cone collapse	R-HSA-3928663	5.456722e-01	0.263
Regulation of PD-L1(CD274) translation	R-HSA-9909620	5.656286e-01	0.247
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	5.656286e-01	0.247
Co-inhibition by CTLA4	R-HSA-389513	5.656286e-01	0.247
Orc1 removal from chromatin	R-HSA-68949	5.623520e-01	0.250
Regulation of RUNX2 expression and activity	R-HSA-8939902	5.669239e-01	0.246
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.920053e-01	0.228
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	5.751921e-01	0.240
Signaling by Erythropoietin	R-HSA-9006335	5.916753e-01	0.228
mRNA Capping	R-HSA-72086	5.916753e-01	0.228
DNA methylation	R-HSA-5334118	5.916753e-01	0.228
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.916753e-01	0.228
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.862692e-01	0.232
Regulation of mitotic cell cycle	R-HSA-453276	5.862692e-01	0.232
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	6.123482e-01	0.213
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	6.123482e-01	0.213
Signaling downstream of RAS mutants	R-HSA-9649948	6.123482e-01	0.213
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.266340e-01	0.203
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.543093e-01	0.184
Erythropoietin activates STAT5	R-HSA-9027283	6.543093e-01	0.184
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	6.543093e-01	0.184
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.543093e-01	0.184
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.543093e-01	0.184
Ribosomal scanning and start codon recognition	R-HSA-72702	6.292527e-01	0.201
Signaling by KIT in disease	R-HSA-9669938	6.415500e-01	0.193
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	6.415500e-01	0.193
FGFR2 alternative splicing	R-HSA-6803529	6.415500e-01	0.193
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.498830e-01	0.187
Erythropoietin activates RAS	R-HSA-9027284	6.556825e-01	0.183
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.556825e-01	0.183
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	6.556825e-01	0.183
Translesion synthesis by REV1	R-HSA-110312	6.556825e-01	0.183
SHC1 events in EGFR signaling	R-HSA-180336	6.556825e-01	0.183
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.556825e-01	0.183
Regulation of PTEN mRNA translation	R-HSA-8943723	6.646766e-01	0.177
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	6.646766e-01	0.177
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	6.646766e-01	0.177
Transcriptional regulation by RUNX2	R-HSA-8878166	2.318935e-01	0.635
Transcriptional regulation by RUNX3	R-HSA-8878159	2.134725e-01	0.671
Nucleotide Excision Repair	R-HSA-5696398	3.110559e-01	0.507
RUNX2 regulates bone development	R-HSA-8941326	1.408929e-01	0.851
Nuclear events mediated by NFE2L2	R-HSA-9759194	5.265561e-01	0.279
Signaling by EGFR	R-HSA-177929	1.417844e-01	0.848
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	3.734463e-01	0.428
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	5.920053e-01	0.228
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	5.920053e-01	0.228
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.952040e-01	0.530
Constitutive Signaling by EGFRvIII	R-HSA-5637810	4.806153e-01	0.318
Signaling by EGFRvIII in Cancer	R-HSA-5637812	4.806153e-01	0.318
DNA Replication Pre-Initiation	R-HSA-69002	4.589892e-01	0.338
FOXO-mediated transcription	R-HSA-9614085	2.339215e-01	0.631
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.498830e-01	0.187
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.498830e-01	0.187
Signaling by SCF-KIT	R-HSA-1433557	3.965144e-01	0.402
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.597653e-01	0.585
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.661644e-01	0.575
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.957152e-01	0.225
Assembly of the pre-replicative complex	R-HSA-68867	3.344248e-01	0.476
Degradation of beta-catenin by the destruction complex	R-HSA-195253	5.711851e-01	0.243
DNA Damage Bypass	R-HSA-73893	6.632854e-01	0.178
EPH-Ephrin signaling	R-HSA-2682334	5.427776e-01	0.265
EGFR downregulation	R-HSA-182971	4.423001e-01	0.354
KEAP1-NFE2L2 pathway	R-HSA-9755511	6.144020e-01	0.212
Regulation of CDH11 function	R-HSA-9762292	1.996557e-01	0.700
VxPx cargo-targeting to cilium	R-HSA-5620916	3.415053e-01	0.467
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.790082e-01	0.320
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.016206e-01	0.521
Cellular response to heat stress	R-HSA-3371556	2.510411e-01	0.600
Chaperone Mediated Autophagy	R-HSA-9613829	5.098696e-01	0.293
Chromosome Maintenance	R-HSA-73886	5.265561e-01	0.279
Signaling by ERBB2	R-HSA-1227986	1.860207e-01	0.730
Transcriptional regulation of testis differentiation	R-HSA-9690406	2.376163e-01	0.624
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.806887e-01	0.743
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.929847e-01	0.533
G0 and Early G1	R-HSA-1538133	1.666303e-01	0.778
p75NTR recruits signalling complexes	R-HSA-209543	5.629136e-01	0.250
Hedgehog 'on' state	R-HSA-5632684	1.483062e-01	0.829
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.985649e-01	0.702
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	5.862692e-01	0.232
Cyclin E associated events during G1/S transition	R-HSA-69202	1.389857e-01	0.857
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	6.244075e-01	0.205
EPHB-mediated forward signaling	R-HSA-3928662	5.761204e-01	0.239
Hedgehog 'off' state	R-HSA-5610787	2.444408e-01	0.612
Disorders of Developmental Biology	R-HSA-9675151	2.376163e-01	0.624
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	3.249044e-01	0.488
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.424138e-01	0.846
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.136922e-01	0.383
Regulation of the apoptosome activity	R-HSA-9627069	4.535192e-01	0.343
Cytochrome c-mediated apoptotic response	R-HSA-111461	5.282425e-01	0.277
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	5.172173e-01	0.286
SHC1 events in ERBB2 signaling	R-HSA-1250196	6.136155e-01	0.212
Integrin signaling	R-HSA-354192	6.748754e-01	0.171
Developmental Cell Lineages	R-HSA-9734767	1.844852e-01	0.734
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	4.457513e-01	0.351
Adipogenesis	R-HSA-9843745	6.600520e-01	0.180
MHC class II antigen presentation	R-HSA-2132295	4.504424e-01	0.346
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.005448e-01	0.698
Formation of lateral plate mesoderm	R-HSA-9758920	2.436177e-01	0.613
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.301179e-01	0.481
Formation of apoptosome	R-HSA-111458	4.535192e-01	0.343
PI3K/AKT activation	R-HSA-198203	4.535192e-01	0.343
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	4.917486e-01	0.308
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.917486e-01	0.308
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	6.109930e-01	0.214
Switching of origins to a post-replicative state	R-HSA-69052	4.857839e-01	0.314
Downregulation of ERBB2 signaling	R-HSA-8863795	2.545358e-01	0.594
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.589961e-01	0.445
Signaling by RAS mutants	R-HSA-6802949	6.123482e-01	0.213
p75NTR signals via NF-kB	R-HSA-193639	6.556825e-01	0.183
Processing of DNA double-strand break ends	R-HSA-5693607	1.741685e-01	0.759
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.585516e-01	0.800
Reelin signalling pathway	R-HSA-8866376	2.005448e-01	0.698
Role of second messengers in netrin-1 signaling	R-HSA-418890	2.929847e-01	0.533
Adrenoceptors	R-HSA-390696	3.724669e-01	0.429
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	3.249044e-01	0.488
DARPP-32 events	R-HSA-180024	3.965053e-01	0.402
PKA activation	R-HSA-163615	5.098696e-01	0.293
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	4.790082e-01	0.320
E2F mediated regulation of DNA replication	R-HSA-113510	5.382315e-01	0.269
Ligand-receptor interactions	R-HSA-5632681	6.109930e-01	0.214
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	5.725709e-01	0.242
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	6.556825e-01	0.183
Telomere C-strand synthesis initiation	R-HSA-174430	6.556825e-01	0.183
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.636334e-01	0.334
Signaling by Hedgehog	R-HSA-5358351	3.745416e-01	0.426
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.082988e-01	0.216
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	5.230027e-01	0.281
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.273921e-01	0.485
Signal attenuation	R-HSA-74749	1.996557e-01	0.700
Ovarian tumor domain proteases	R-HSA-5689896	2.661644e-01	0.575
PKA-mediated phosphorylation of CREB	R-HSA-111931	3.679556e-01	0.434
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.107186e-01	0.386
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.107186e-01	0.386
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.107186e-01	0.386
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.107186e-01	0.386
DNA Double Strand Break Response	R-HSA-5693606	1.821478e-01	0.740
G1 Phase	R-HSA-69236	4.154862e-01	0.381
Cyclin D associated events in G1	R-HSA-69231	4.154862e-01	0.381
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.436807e-01	0.843
G1/S DNA Damage Checkpoints	R-HSA-69615	4.600846e-01	0.337
Circadian clock	R-HSA-9909396	2.268960e-01	0.644
TNF signaling	R-HSA-75893	3.449782e-01	0.462
Signaling by WNT in cancer	R-HSA-4791275	4.648963e-01	0.333
Signaling by Nuclear Receptors	R-HSA-9006931	3.561911e-01	0.448
Neurexins and neuroligins	R-HSA-6794361	1.772768e-01	0.751
Post-transcriptional silencing by small RNAs	R-HSA-426496	2.005448e-01	0.698
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.436177e-01	0.613
Abacavir transmembrane transport	R-HSA-2161517	2.870102e-01	0.542
Activation of SMO	R-HSA-5635838	2.128374e-01	0.672
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	2.612926e-01	0.583
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	3.568173e-01	0.448
Calcineurin activates NFAT	R-HSA-2025928	4.136922e-01	0.383
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.622523e-01	0.250
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	4.872078e-01	0.312
Fanconi Anemia Pathway	R-HSA-6783310	5.944485e-01	0.226
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.543093e-01	0.184
Sema3A PAK dependent Axon repulsion	R-HSA-399954	6.556825e-01	0.183
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.227193e-01	0.491
Homology Directed Repair	R-HSA-5693538	1.583388e-01	0.800
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.458449e-01	0.836
Regulation of TNFR1 signaling	R-HSA-5357905	3.083970e-01	0.511
Prolonged ERK activation events	R-HSA-169893	4.198151e-01	0.377
Synaptic adhesion-like molecules	R-HSA-8849932	1.390118e-01	0.857
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	3.249044e-01	0.488
Signalling to ERKs	R-HSA-187687	2.311554e-01	0.636
mTORC1-mediated signalling	R-HSA-166208	4.205445e-01	0.376
Meiosis	R-HSA-1500620	3.080391e-01	0.511
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.629136e-01	0.250
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.996557e-01	0.700
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.470071e-01	0.460
Calmodulin induced events	R-HSA-111933	2.484702e-01	0.605
G1/S Transition	R-HSA-69206	1.617308e-01	0.791
Protein-protein interactions at synapses	R-HSA-6794362	4.175136e-01	0.379
Inhibition of nitric oxide production	R-HSA-9636249	4.456970e-01	0.351
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.074083e-01	0.295
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.622523e-01	0.250
Ub-specific processing proteases	R-HSA-5689880	3.375467e-01	0.472
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.109930e-01	0.214
Lysosphingolipid and LPA receptors	R-HSA-419408	6.556825e-01	0.183
p38MAPK events	R-HSA-171007	6.556825e-01	0.183
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	3.603806e-01	0.443
p53-Dependent G1 DNA Damage Response	R-HSA-69563	3.603806e-01	0.443
Post NMDA receptor activation events	R-HSA-438064	3.473434e-01	0.459
PTEN Regulation	R-HSA-6807070	6.610245e-01	0.180
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.889029e-01	0.539
CaM pathway	R-HSA-111997	2.484702e-01	0.605
DNA Repair	R-HSA-73894	2.842303e-01	0.546
Neurofascin interactions	R-HSA-447043	2.870102e-01	0.542
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.108826e-01	0.676
Rap1 signalling	R-HSA-392517	5.382315e-01	0.269
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	6.543093e-01	0.184
Developmental Biology	R-HSA-1266738	1.939300e-01	0.712
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.107186e-01	0.386
mRNA Editing	R-HSA-75072	4.136922e-01	0.383
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	3.771545e-01	0.423
Organelle biogenesis and maintenance	R-HSA-1852241	2.380406e-01	0.623
RMTs methylate histone arginines	R-HSA-3214858	4.154862e-01	0.381
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.591864e-01	0.586
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.813893e-01	0.741
Signaling by NOTCH1	R-HSA-1980143	2.928483e-01	0.533
Signaling by TGFB family members	R-HSA-9006936	2.833027e-01	0.548
PLC beta mediated events	R-HSA-112043	5.669239e-01	0.246
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	5.216884e-01	0.283
Reproduction	R-HSA-1474165	2.816773e-01	0.550
TCF dependent signaling in response to WNT	R-HSA-201681	2.205092e-01	0.657
Kidney development	R-HSA-9830369	6.586811e-01	0.181
Ca-dependent events	R-HSA-111996	3.775374e-01	0.423
MTOR signalling	R-HSA-165159	5.382775e-01	0.269
Formation of editosomes by ADAR proteins	R-HSA-77042	2.102158e-01	0.677
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.423478e-01	0.847
Regulation of CDH11 gene transcription	R-HSA-9762293	1.703011e-01	0.769
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.703011e-01	0.769
CDC6 association with the ORC:origin complex	R-HSA-68689	2.436177e-01	0.613
mRNA Editing: A to I Conversion	R-HSA-75064	3.762592e-01	0.425
C6 deamination of adenosine	R-HSA-75102	3.762592e-01	0.425
Ionotropic activity of kainate receptors	R-HSA-451306	2.300881e-01	0.638
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	2.128374e-01	0.672
Signaling by AMER1 mutants	R-HSA-4839748	2.612926e-01	0.583
Signaling by AXIN mutants	R-HSA-4839735	2.612926e-01	0.583
Regulation of PTEN localization	R-HSA-8948747	3.301179e-01	0.481
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.456970e-01	0.351
Signaling by LTK	R-HSA-9842663	2.929847e-01	0.533
Co-stimulation by ICOS	R-HSA-9927354	3.724669e-01	0.429
Notch-HLH transcription pathway	R-HSA-350054	2.379795e-01	0.623
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.249044e-01	0.488
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	4.136922e-01	0.383
Unwinding of DNA	R-HSA-176974	4.136922e-01	0.383
EGFR Transactivation by Gastrin	R-HSA-2179392	4.535192e-01	0.343
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	4.198151e-01	0.377
Phase 4 - resting membrane potential	R-HSA-5576886	4.198151e-01	0.377
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	3.555339e-01	0.449
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.622523e-01	0.250
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.622523e-01	0.250
Regulation of TP53 Degradation	R-HSA-6804757	3.969666e-01	0.401
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.471133e-01	0.460
Deadenylation-dependent mRNA decay	R-HSA-429914	3.942168e-01	0.404
Cell junction organization	R-HSA-446728	2.262521e-01	0.645
DAG and IP3 signaling	R-HSA-1489509	4.344097e-01	0.362
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	5.098696e-01	0.293
Signaling by FGFR2 IIIa TM	R-HSA-8851708	5.382315e-01	0.269
Pentose phosphate pathway disease	R-HSA-6791465	6.109930e-01	0.214
Sensory perception of salty taste	R-HSA-9730628	6.109930e-01	0.214
Formation of the Editosome	R-HSA-75094	6.109930e-01	0.214
Maternal to zygotic transition (MZT)	R-HSA-9816359	4.504424e-01	0.346
Activation of kainate receptors upon glutamate binding	R-HSA-451326	5.690157e-01	0.245
Signalling to RAS	R-HSA-167044	5.920053e-01	0.228
Adherens junctions interactions	R-HSA-418990	3.828286e-01	0.417
Cell-cell junction organization	R-HSA-421270	5.223647e-01	0.282
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.375467e-01	0.472
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.375467e-01	0.472
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	3.691791e-01	0.433
Signaling by WNT	R-HSA-195721	6.215277e-01	0.207
G-protein beta:gamma signalling	R-HSA-397795	6.748754e-01	0.171
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	2.379795e-01	0.623
Pexophagy	R-HSA-9664873	4.535192e-01	0.343
Frs2-mediated activation	R-HSA-170968	5.957152e-01	0.225
Listeria monocytogenes entry into host cells	R-HSA-8876384	6.173213e-01	0.209
Cell-Cell communication	R-HSA-1500931	3.161687e-01	0.500
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	4.941564e-01	0.306
UCH proteinases	R-HSA-5689603	6.576658e-01	0.182
HIV Life Cycle	R-HSA-162587	1.421949e-01	0.847
Signaling by PTK6	R-HSA-8848021	5.987590e-01	0.223
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.987590e-01	0.223
HIV Infection	R-HSA-162906	3.212914e-01	0.493
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	4.206212e-01	0.376
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	5.382315e-01	0.269
Heme signaling	R-HSA-9707616	2.102620e-01	0.677
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.965053e-01	0.402
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	4.355256e-01	0.361
Diseases of programmed cell death	R-HSA-9645723	4.738682e-01	0.324
Signaling by NOTCH	R-HSA-157118	4.292067e-01	0.367
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.819617e-01	0.740
Receptor Mediated Mitophagy	R-HSA-8934903	4.535192e-01	0.343
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	5.622523e-01	0.250
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.456722e-01	0.263
ERK/MAPK targets	R-HSA-198753	5.920053e-01	0.228
Formation of the ureteric bud	R-HSA-9830674	6.646766e-01	0.177
Host Interactions of HIV factors	R-HSA-162909	2.808765e-01	0.551
Negative regulation of FLT3	R-HSA-9706369	4.198151e-01	0.377
G-protein mediated events	R-HSA-112040	6.586811e-01	0.181
Nuclear signaling by ERBB4	R-HSA-1251985	3.210302e-01	0.493
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	5.862692e-01	0.232
Muscarinic acetylcholine receptors	R-HSA-390648	5.622523e-01	0.250
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.109930e-01	0.214
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	6.109930e-01	0.214
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	6.415500e-01	0.193
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	6.415500e-01	0.193
Programmed Cell Death	R-HSA-5357801	2.748741e-01	0.561
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.389857e-01	0.857
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.914189e-01	0.535
Semaphorin interactions	R-HSA-373755	4.600846e-01	0.337
Golgi-to-ER retrograde transport	R-HSA-8856688	2.268960e-01	0.644
Transcriptional Regulation by VENTX	R-HSA-8853884	2.108826e-01	0.676
Signaling by ERBB4	R-HSA-1236394	2.665774e-01	0.574
RET signaling	R-HSA-8853659	2.484702e-01	0.605
Acyl chain remodelling of PS	R-HSA-1482801	4.971171e-01	0.304
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	5.172173e-01	0.286
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.957152e-01	0.225
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.987590e-01	0.223
Downstream signal transduction	R-HSA-186763	6.348083e-01	0.197
Rab regulation of trafficking	R-HSA-9007101	5.809191e-01	0.236
Interleukin-1 family signaling	R-HSA-446652	6.244075e-01	0.205
Oncogene Induced Senescence	R-HSA-2559585	5.519023e-01	0.258
Regulation of NPAS4 gene expression	R-HSA-9768759	2.630225e-01	0.580
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.035607e-01	0.691
TBC/RABGAPs	R-HSA-8854214	3.965144e-01	0.402
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	4.107186e-01	0.386
Cellular Senescence	R-HSA-2559583	1.488358e-01	0.827
Ion homeostasis	R-HSA-5578775	4.830359e-01	0.316
L1CAM interactions	R-HSA-373760	6.692789e-01	0.174
Uptake and function of anthrax toxins	R-HSA-5210891	4.806153e-01	0.318
Signaling by TGFBR3	R-HSA-9839373	3.083970e-01	0.511
Breakdown of the nuclear lamina	R-HSA-352238	2.981280e-01	0.526
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	2.005448e-01	0.698
DSCAM interactions	R-HSA-376172	3.762592e-01	0.425
Tandem pore domain potassium channels	R-HSA-1296346	1.996557e-01	0.700
SLC-mediated bile acid transport	R-HSA-9958517	3.724669e-01	0.429
GP1b-IX-V activation signalling	R-HSA-430116	4.136922e-01	0.383
Sensory perception of sour taste	R-HSA-9729555	5.074083e-01	0.295
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	4.535192e-01	0.343
PTK6 Down-Regulation	R-HSA-8849472	5.622523e-01	0.250
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.720200e-01	0.326
CD28 dependent PI3K/Akt signaling	R-HSA-389357	5.456722e-01	0.263
Signaling by FGFR4 in disease	R-HSA-5655291	6.266340e-01	0.203
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	6.266340e-01	0.203
Formation of the nephric duct	R-HSA-9830364	4.971171e-01	0.304
Co-stimulation by CD28	R-HSA-389356	4.904910e-01	0.309
Signaling by NTRK3 (TRKC)	R-HSA-9034015	6.173213e-01	0.209
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	6.034925e-01	0.219
PI Metabolism	R-HSA-1483255	1.886125e-01	0.724
Transcriptional Regulation by E2F6	R-HSA-8953750	3.024939e-01	0.519
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.423478e-01	0.847
Cell-extracellular matrix interactions	R-HSA-446353	1.888427e-01	0.724
Zygotic genome activation (ZGA)	R-HSA-9819196	3.679556e-01	0.434
FLT3 signaling in disease	R-HSA-9682385	5.725709e-01	0.242
Histamine receptors	R-HSA-390650	4.456970e-01	0.351
G1/S-Specific Transcription	R-HSA-69205	1.408929e-01	0.851
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	3.568173e-01	0.448
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	4.136922e-01	0.383
tRNA processing in the nucleus	R-HSA-6784531	2.102620e-01	0.677
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	6.728054e-01	0.172
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	6.556825e-01	0.183
Potential therapeutics for SARS	R-HSA-9679191	4.250501e-01	0.372
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	3.885150e-01	0.411
Spry regulation of FGF signaling	R-HSA-1295596	6.556825e-01	0.183
Regulation of PTEN gene transcription	R-HSA-8943724	4.107186e-01	0.386
Signaling by NTRK2 (TRKB)	R-HSA-9006115	5.456722e-01	0.263
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.074083e-01	0.295
Trafficking of AMPA receptors	R-HSA-399719	4.423001e-01	0.354
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.109930e-01	0.214
Relaxin receptors	R-HSA-444821	6.109930e-01	0.214
NADPH regeneration	R-HSA-389542	6.543093e-01	0.184
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.314080e-01	0.200
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	6.748754e-01	0.171
Inositol phosphate metabolism	R-HSA-1483249	3.940042e-01	0.404
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.724811e-01	0.763
Gene Silencing by RNA	R-HSA-211000	2.469955e-01	0.607
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.629136e-01	0.250
Cleavage of the damaged purine	R-HSA-110331	5.927299e-01	0.227
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	6.415500e-01	0.193
Depurination	R-HSA-73927	6.123504e-01	0.213
Activation of BH3-only proteins	R-HSA-114452	6.136155e-01	0.212
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.415500e-01	0.193
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	1.961173e-01	0.707
LGI-ADAM interactions	R-HSA-5682910	4.917486e-01	0.308
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	4.648963e-01	0.333
OAS antiviral response	R-HSA-8983711	5.629136e-01	0.250
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.109930e-01	0.214
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	6.109930e-01	0.214
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	6.109930e-01	0.214
Lipid particle organization	R-HSA-8964572	6.543093e-01	0.184
CREB3 factors activate genes	R-HSA-8874211	6.543093e-01	0.184
Physiological factors	R-HSA-5578768	3.568173e-01	0.448
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.307584e-01	0.275
Signaling by ALK	R-HSA-201556	6.314080e-01	0.200
Cleavage of the damaged pyrimidine	R-HSA-110329	5.382775e-01	0.269
Depyrimidination	R-HSA-73928	5.382775e-01	0.269
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	3.555339e-01	0.449
Maturation of nucleoprotein	R-HSA-9694631	5.382315e-01	0.269
XBP1(S) activates chaperone genes	R-HSA-381038	4.457513e-01	0.351
Glucose metabolism	R-HSA-70326	2.903774e-01	0.537
IRE1alpha activates chaperones	R-HSA-381070	5.292143e-01	0.276
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	4.872078e-01	0.312
Maturation of nucleoprotein	R-HSA-9683610	5.957152e-01	0.225
Signaling by Leptin	R-HSA-2586552	4.535192e-01	0.343
Regulation of RAS by GAPs	R-HSA-5658442	6.792956e-01	0.168
RAF/MAP kinase cascade	R-HSA-5673001	6.823697e-01	0.166
Translesion synthesis by POLI	R-HSA-5656121	6.828937e-01	0.166
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	6.828937e-01	0.166
Defective GALNT12 causes CRCS1	R-HSA-5083636	6.828937e-01	0.166
Defective GALNT3 causes HFTC	R-HSA-5083625	6.828937e-01	0.166
Signaling by RAF1 mutants	R-HSA-9656223	6.850274e-01	0.164
Negative regulation of MAPK pathway	R-HSA-5675221	6.850274e-01	0.164
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.866966e-01	0.163
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	6.866966e-01	0.163
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.928045e-01	0.159
MET activates PI3K/AKT signaling	R-HSA-8851907	6.928045e-01	0.159
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.928045e-01	0.159
TRIF-mediated programmed cell death	R-HSA-2562578	6.928045e-01	0.159
Recycling of eIF2:GDP	R-HSA-72731	6.928045e-01	0.159
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	6.928045e-01	0.159
mRNA Editing: C to U Conversion	R-HSA-72200	6.928045e-01	0.159
PTK6 Expression	R-HSA-8849473	6.928045e-01	0.159
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.928045e-01	0.159
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.928045e-01	0.159
VLDL clearance	R-HSA-8964046	6.928045e-01	0.159
Ca2+ activated K+ channels	R-HSA-1296052	6.928045e-01	0.159
Phase 3 - rapid repolarisation	R-HSA-5576890	6.928045e-01	0.159
CHL1 interactions	R-HSA-447041	6.928045e-01	0.159
Uptake and function of diphtheria toxin	R-HSA-5336415	6.928045e-01	0.159
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.928045e-01	0.159
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	6.937271e-01	0.159
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	6.937271e-01	0.159
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	6.937271e-01	0.159
HSF1-dependent transactivation	R-HSA-3371571	6.948042e-01	0.158
Sensory processing of sound	R-HSA-9659379	6.968871e-01	0.157
Muscle contraction	R-HSA-397014	7.024108e-01	0.153
Aquaporin-mediated transport	R-HSA-445717	7.041237e-01	0.152
MAP kinase activation	R-HSA-450294	7.041237e-01	0.152
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.076148e-01	0.150
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.076148e-01	0.150
Interleukin-7 signaling	R-HSA-1266695	7.076148e-01	0.150
Translesion synthesis by POLK	R-HSA-5655862	7.083167e-01	0.150
Glycine degradation	R-HSA-6783984	7.083167e-01	0.150
Acetylcholine regulates insulin secretion	R-HSA-399997	7.083167e-01	0.150
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	7.083167e-01	0.150
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	7.083167e-01	0.150
Synthesis of PG	R-HSA-1483148	7.083167e-01	0.150
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	7.083167e-01	0.150
Clathrin-mediated endocytosis	R-HSA-8856828	7.088569e-01	0.149
Transcriptional Regulation by NPAS4	R-HSA-9634815	7.098049e-01	0.149
Dual Incision in GG-NER	R-HSA-5696400	7.117849e-01	0.148
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.117849e-01	0.148
Mitophagy	R-HSA-5205647	7.117849e-01	0.148
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.117849e-01	0.148
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.129822e-01	0.147
NoRC negatively regulates rRNA expression	R-HSA-427413	7.129822e-01	0.147
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	7.135402e-01	0.147
Activation of HOX genes during differentiation	R-HSA-5619507	7.135402e-01	0.147
MAPK family signaling cascades	R-HSA-5683057	7.150856e-01	0.146
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.177065e-01	0.144
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.178255e-01	0.144
NCAM signaling for neurite out-growth	R-HSA-375165	7.178255e-01	0.144
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	7.242938e-01	0.140
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.270150e-01	0.138
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	7.270150e-01	0.138
Activation of RAS in B cells	R-HSA-1169092	7.270150e-01	0.138
Activated NTRK2 signals through PI3K	R-HSA-9028335	7.270150e-01	0.138
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.270150e-01	0.138
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	7.270150e-01	0.138
Regulation by c-FLIP	R-HSA-3371378	7.270150e-01	0.138
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	7.270150e-01	0.138
TGFBR3 PTM regulation	R-HSA-9839383	7.270150e-01	0.138
Dimerization of procaspase-8	R-HSA-69416	7.270150e-01	0.138
Alpha-defensins	R-HSA-1462054	7.270150e-01	0.138
Downregulation of ERBB4 signaling	R-HSA-1253288	7.270150e-01	0.138
Activated NTRK2 signals through FYN	R-HSA-9032500	7.270150e-01	0.138
Signaling by EGFR in Cancer	R-HSA-1643713	7.274434e-01	0.138
Metalloprotease DUBs	R-HSA-5689901	7.274434e-01	0.138
Myogenesis	R-HSA-525793	7.274434e-01	0.138
MAPK1/MAPK3 signaling	R-HSA-5684996	7.290074e-01	0.137
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	7.290506e-01	0.137
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	7.290506e-01	0.137
Membrane Trafficking	R-HSA-199991	7.304463e-01	0.136
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.320122e-01	0.135
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	7.320122e-01	0.135
Elevation of cytosolic Ca2+ levels	R-HSA-139853	7.320122e-01	0.135
MyD88 cascade initiated on plasma membrane	R-HSA-975871	7.370483e-01	0.133
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	7.370483e-01	0.133
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	7.370483e-01	0.133
Base-Excision Repair, AP Site Formation	R-HSA-73929	7.382691e-01	0.132
Ion transport by P-type ATPases	R-HSA-936837	7.439188e-01	0.128
Vif-mediated degradation of APOBEC3G	R-HSA-180585	7.455301e-01	0.128
Interaction between L1 and Ankyrins	R-HSA-445095	7.462011e-01	0.127
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.462011e-01	0.127
RNA Polymerase I Promoter Opening	R-HSA-73728	7.462011e-01	0.127
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	7.462011e-01	0.127
Maturation of hRSV A proteins	R-HSA-9828806	7.462011e-01	0.127
Cardiac conduction	R-HSA-5576891	7.470257e-01	0.127
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.533617e-01	0.123
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	7.540495e-01	0.123
Apoptotic factor-mediated response	R-HSA-111471	7.540495e-01	0.123
PKA activation in glucagon signalling	R-HSA-164378	7.540495e-01	0.123
RNA Polymerase III Transcription Termination	R-HSA-73980	7.540495e-01	0.123
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	7.540495e-01	0.123
Tie2 Signaling	R-HSA-210993	7.540495e-01	0.123
Platelet sensitization by LDL	R-HSA-432142	7.540495e-01	0.123
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	7.540495e-01	0.123
CASP8 activity is inhibited	R-HSA-5218900	7.574174e-01	0.121
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.574174e-01	0.121
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.574174e-01	0.121
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.574174e-01	0.121
Interleukin-1 processing	R-HSA-448706	7.574174e-01	0.121
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.574174e-01	0.121
Respiratory syncytial virus genome replication	R-HSA-9834752	7.574174e-01	0.121
Cellular response to mitochondrial stress	R-HSA-9840373	7.574174e-01	0.121
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.574174e-01	0.121
Butyrophilin (BTN) family interactions	R-HSA-8851680	7.574174e-01	0.121
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	7.612329e-01	0.118
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.612620e-01	0.118
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.620675e-01	0.118
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.620675e-01	0.118
Telomere Extension By Telomerase	R-HSA-171319	7.639120e-01	0.117
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.646821e-01	0.117
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.646821e-01	0.117
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.646821e-01	0.117
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.667541e-01	0.115
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.667541e-01	0.115
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.667541e-01	0.115
Extra-nuclear estrogen signaling	R-HSA-9009391	7.672312e-01	0.115
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.745041e-01	0.111
STING mediated induction of host immune responses	R-HSA-1834941	7.745041e-01	0.111
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	7.745041e-01	0.111
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	7.756268e-01	0.110
Recycling pathway of L1	R-HSA-437239	7.756268e-01	0.110
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	7.761717e-01	0.110
Oxidative Stress Induced Senescence	R-HSA-2559580	7.767362e-01	0.110
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.767871e-01	0.110
Regulation of CDH1 Function	R-HSA-9764561	7.771257e-01	0.110
Cellular response to chemical stress	R-HSA-9711123	7.778149e-01	0.109
Termination of translesion DNA synthesis	R-HSA-5656169	7.806047e-01	0.108
Platelet calcium homeostasis	R-HSA-418360	7.806047e-01	0.108
Regulation of gene expression in beta cells	R-HSA-210745	7.806047e-01	0.108
MET activates RAP1 and RAC1	R-HSA-8875555	7.844355e-01	0.105
MAPK3 (ERK1) activation	R-HSA-110056	7.844355e-01	0.105
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.844355e-01	0.105
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	7.844355e-01	0.105
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.844355e-01	0.105
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.844355e-01	0.105
Formation of intermediate mesoderm	R-HSA-9761174	7.844355e-01	0.105
Maturation of spike protein	R-HSA-9683686	7.844355e-01	0.105
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	7.844355e-01	0.105
Metal sequestration by antimicrobial proteins	R-HSA-6799990	7.844355e-01	0.105
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	7.868650e-01	0.104
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	7.868650e-01	0.104
Dual incision in TC-NER	R-HSA-6782135	7.890675e-01	0.103
Stabilization of p53	R-HSA-69541	7.903622e-01	0.102
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	7.903622e-01	0.102
DNA Replication	R-HSA-69306	7.914996e-01	0.102
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.934551e-01	0.100
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.934551e-01	0.100
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.934551e-01	0.100
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.934551e-01	0.100
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.934551e-01	0.100
Signaling by NODAL	R-HSA-1181150	7.934551e-01	0.100
Negative regulation of MET activity	R-HSA-6807004	7.934551e-01	0.100
Nephrin family interactions	R-HSA-373753	7.934551e-01	0.100
Protein hydroxylation	R-HSA-9629569	7.934551e-01	0.100
Signal transduction by L1	R-HSA-445144	7.934551e-01	0.100
Opioid Signalling	R-HSA-111885	7.949146e-01	0.100
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	7.949146e-01	0.100
Regulation of beta-cell development	R-HSA-186712	8.005143e-01	0.097
Degradation of CDH1	R-HSA-9766229	8.009524e-01	0.096
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.034556e-01	0.095
Attenuation phase	R-HSA-3371568	8.038222e-01	0.095
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.058624e-01	0.094
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	8.084458e-01	0.092
Interleukin-2 signaling	R-HSA-9020558	8.084458e-01	0.092
Activated NTRK3 signals through RAS	R-HSA-9034864	8.084458e-01	0.092
vRNA Synthesis	R-HSA-192814	8.084458e-01	0.092
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	8.084458e-01	0.092
Synthesis of PI	R-HSA-1483226	8.084458e-01	0.092
Bicarbonate transporters	R-HSA-425381	8.084458e-01	0.092
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.084458e-01	0.092
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	8.084458e-01	0.092
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.084458e-01	0.092
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.084458e-01	0.092
PECAM1 interactions	R-HSA-210990	8.084458e-01	0.092
COPI-mediated anterograde transport	R-HSA-6807878	8.088567e-01	0.092
Potassium Channels	R-HSA-1296071	8.088567e-01	0.092
MyD88 deficiency (TLR2/4)	R-HSA-5602498	8.109836e-01	0.091
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	8.109836e-01	0.091
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.110659e-01	0.091
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.110697e-01	0.091
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.110697e-01	0.091
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	8.117722e-01	0.091
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	8.117722e-01	0.091
Interleukin-17 signaling	R-HSA-448424	8.117722e-01	0.091
Signaling by FGFR2 in disease	R-HSA-5655253	8.127413e-01	0.090
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.130712e-01	0.090
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.165715e-01	0.088
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.165715e-01	0.088
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.165715e-01	0.088
Resolution of Abasic Sites (AP sites)	R-HSA-73933	8.165715e-01	0.088
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.165715e-01	0.088
Unfolded Protein Response (UPR)	R-HSA-381119	8.186223e-01	0.087
IRS-related events triggered by IGF1R	R-HSA-2428928	8.219561e-01	0.085
Base Excision Repair	R-HSA-73884	8.237683e-01	0.084
DNA strand elongation	R-HSA-69190	8.249059e-01	0.084
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	8.271713e-01	0.082
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	8.271713e-01	0.082
Glutathione synthesis and recycling	R-HSA-174403	8.271713e-01	0.082
Mitochondrial calcium ion transport	R-HSA-8949215	8.271713e-01	0.082
Synthesis of DNA	R-HSA-69239	8.279925e-01	0.082
MAP2K and MAPK activation	R-HSA-5674135	8.286315e-01	0.082
Degradation of GLI1 by the proteasome	R-HSA-5610780	8.286315e-01	0.082
Intra-Golgi traffic	R-HSA-6811438	8.286315e-01	0.082
Signaling by FGFR1 in disease	R-HSA-5655302	8.286315e-01	0.082
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.286315e-01	0.082
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.297830e-01	0.081
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.297830e-01	0.081
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	8.297830e-01	0.081
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.297830e-01	0.081
Activated NTRK2 signals through RAS	R-HSA-9026519	8.297830e-01	0.081
NF-kB is activated and signals survival	R-HSA-209560	8.297830e-01	0.081
Reduction of cytosolic Ca++ levels	R-HSA-418359	8.297830e-01	0.081
Sodium/Calcium exchangers	R-HSA-425561	8.297830e-01	0.081
Integration of provirus	R-HSA-162592	8.297830e-01	0.081
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.319702e-01	0.080
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.321866e-01	0.080
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	8.346380e-01	0.079
Uptake and actions of bacterial toxins	R-HSA-5339562	8.346380e-01	0.079
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	8.355941e-01	0.078
Stimuli-sensing channels	R-HSA-2672351	8.355941e-01	0.078
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	8.378692e-01	0.077
Regulation of necroptotic cell death	R-HSA-5675482	8.378692e-01	0.077
Cytoprotection by HMOX1	R-HSA-9707564	8.397579e-01	0.076
RNA Polymerase I Transcription Initiation	R-HSA-73762	8.400248e-01	0.076
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.400248e-01	0.076
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	8.400486e-01	0.076
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.415275e-01	0.075
RAF-independent MAPK1/3 activation	R-HSA-112409	8.420993e-01	0.075
MyD88 dependent cascade initiated on endosome	R-HSA-975155	8.429353e-01	0.074
Mitochondrial biogenesis	R-HSA-1592230	8.447692e-01	0.073
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.447758e-01	0.073
Smooth Muscle Contraction	R-HSA-445355	8.447758e-01	0.073
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	8.451991e-01	0.073
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.478444e-01	0.072
Signaling by FGFR in disease	R-HSA-1226099	8.486844e-01	0.071
Scavenging by Class F Receptors	R-HSA-3000484	8.487446e-01	0.071
IRAK1 recruits IKK complex	R-HSA-937039	8.487446e-01	0.071
Polymerase switching	R-HSA-69091	8.487446e-01	0.071
Leading Strand Synthesis	R-HSA-69109	8.487446e-01	0.071
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.487446e-01	0.071
MET activates RAS signaling	R-HSA-8851805	8.487446e-01	0.071
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	8.487446e-01	0.071
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	8.487446e-01	0.071
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.487446e-01	0.071
SHC-related events triggered by IGF1R	R-HSA-2428933	8.487446e-01	0.071
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.487446e-01	0.071
Estrogen biosynthesis	R-HSA-193144	8.487446e-01	0.071
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.487446e-01	0.071
Interleukin-15 signaling	R-HSA-8983432	8.487446e-01	0.071
Interleukin-1 signaling	R-HSA-9020702	8.488277e-01	0.071
Resolution of D-Loop Structures	R-HSA-5693537	8.499950e-01	0.071
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.499950e-01	0.071
IGF1R signaling cascade	R-HSA-2428924	8.506395e-01	0.070
Signaling by FGFR4	R-HSA-5654743	8.507751e-01	0.070
Defective pyroptosis	R-HSA-9710421	8.507751e-01	0.070
Interferon Signaling	R-HSA-913531	8.542856e-01	0.068
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.543946e-01	0.068
MAPK6/MAPK4 signaling	R-HSA-5687128	8.558131e-01	0.068
Interleukin receptor SHC signaling	R-HSA-912526	8.558474e-01	0.068
Termination of O-glycan biosynthesis	R-HSA-977068	8.558474e-01	0.068
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	8.558474e-01	0.068
Organic anion transport by SLCO transporters	R-HSA-879518	8.558474e-01	0.068
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	8.558474e-01	0.068
Growth hormone receptor signaling	R-HSA-982772	8.558474e-01	0.068
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	8.593184e-01	0.066
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.609065e-01	0.065
Amine ligand-binding receptors	R-HSA-375280	8.609065e-01	0.065
Integration of energy metabolism	R-HSA-163685	8.612671e-01	0.065
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	8.613226e-01	0.065
NOD1/2 Signaling Pathway	R-HSA-168638	8.613226e-01	0.065
Signaling by NOTCH2	R-HSA-1980145	8.613226e-01	0.065
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.635114e-01	0.064
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	8.635114e-01	0.064
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.648263e-01	0.063
Acetylcholine binding and downstream events	R-HSA-181431	8.655949e-01	0.063
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	8.655949e-01	0.063
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.655949e-01	0.063
Chylomicron remodeling	R-HSA-8963901	8.655949e-01	0.063
Mtb iron assimilation by chelation	R-HSA-1222449	8.655949e-01	0.063
Processing of SMDT1	R-HSA-8949664	8.655949e-01	0.063
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.655949e-01	0.063
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.655949e-01	0.063
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.670869e-01	0.062
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	8.697804e-01	0.061
Defective CFTR causes cystic fibrosis	R-HSA-5678895	8.704439e-01	0.060
Platelet Aggregation (Plug Formation)	R-HSA-76009	8.704439e-01	0.060
Signaling by FGFR3	R-HSA-5654741	8.704439e-01	0.060
Cellular responses to stress	R-HSA-2262752	8.714689e-01	0.060
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.721434e-01	0.059
HDR through Homologous Recombination (HRR)	R-HSA-5685942	8.754280e-01	0.058
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	8.793590e-01	0.056
Diseases of DNA repair	R-HSA-9675135	8.794123e-01	0.056
RNA Polymerase I Transcription	R-HSA-73864	8.795280e-01	0.056
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	8.801114e-01	0.055
Tight junction interactions	R-HSA-420029	8.801114e-01	0.055
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.801114e-01	0.055
IRS-mediated signalling	R-HSA-112399	8.803081e-01	0.055
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.805689e-01	0.055
Retrograde neurotrophin signalling	R-HSA-177504	8.805689e-01	0.055
NRIF signals cell death from the nucleus	R-HSA-205043	8.805689e-01	0.055
cGMP effects	R-HSA-418457	8.805689e-01	0.055
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.805689e-01	0.055
Ciprofloxacin ADME	R-HSA-9793528	8.805689e-01	0.055
HDL assembly	R-HSA-8963896	8.805689e-01	0.055
Signal regulatory protein family interactions	R-HSA-391160	8.805689e-01	0.055
Zinc transporters	R-HSA-435354	8.805689e-01	0.055
P2Y receptors	R-HSA-417957	8.805689e-01	0.055
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.805689e-01	0.055
HSF1 activation	R-HSA-3371511	8.817415e-01	0.055
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.817415e-01	0.055
RNA Polymerase III Transcription	R-HSA-74158	8.817415e-01	0.055
Triglyceride catabolism	R-HSA-163560	8.817415e-01	0.055
FGFR2 mutant receptor activation	R-HSA-1839126	8.817415e-01	0.055
HCMV Early Events	R-HSA-9609690	8.826621e-01	0.054
Selective autophagy	R-HSA-9663891	8.840295e-01	0.054
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	8.874011e-01	0.052
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	8.878367e-01	0.052
Synthesis of PC	R-HSA-1483191	8.878367e-01	0.052
Telomere Maintenance	R-HSA-157579	8.886971e-01	0.051
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.907742e-01	0.050
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.907742e-01	0.050
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.907742e-01	0.050
Abacavir ADME	R-HSA-2161522	8.907742e-01	0.050
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.907742e-01	0.050
Urea cycle	R-HSA-70635	8.907742e-01	0.050
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.909107e-01	0.050
Degradation of AXIN	R-HSA-4641257	8.909107e-01	0.050
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.909107e-01	0.050
Degradation of DVL	R-HSA-4641258	8.909107e-01	0.050
SLC-mediated transport of organic cations	R-HSA-549127	8.909107e-01	0.050
Influenza Infection	R-HSA-168255	8.927309e-01	0.049
VEGFA-VEGFR2 Pathway	R-HSA-4420097	8.928235e-01	0.049
Signaling by FGFR2	R-HSA-5654738	8.928733e-01	0.049
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	8.928733e-01	0.049
PKR-mediated signaling	R-HSA-9833482	8.928733e-01	0.049
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.938755e-01	0.049
G beta:gamma signalling through BTK	R-HSA-8964315	8.938755e-01	0.049
Protein lipoylation	R-HSA-9857492	8.938755e-01	0.049
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.938755e-01	0.049
Signaling by Activin	R-HSA-1502540	8.938755e-01	0.049
Biotin transport and metabolism	R-HSA-196780	8.938755e-01	0.049
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.938755e-01	0.049
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.938755e-01	0.049
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	8.938755e-01	0.049
IRF3-mediated induction of type I IFN	R-HSA-3270619	8.938755e-01	0.049
Protein methylation	R-HSA-8876725	8.938755e-01	0.049
DNA Damage Reversal	R-HSA-73942	8.938755e-01	0.049
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	8.987715e-01	0.046
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.994373e-01	0.046
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.005501e-01	0.045
Cristae formation	R-HSA-8949613	9.005501e-01	0.045
Signaling by FGFR3 in disease	R-HSA-5655332	9.005501e-01	0.045
Signaling by BMP	R-HSA-201451	9.005501e-01	0.045
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.021777e-01	0.045
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	9.057001e-01	0.043
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.057001e-01	0.043
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	9.057001e-01	0.043
Killing mechanisms	R-HSA-9664420	9.057001e-01	0.043
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	9.057001e-01	0.043
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.057001e-01	0.043
Regulation of NF-kappa B signaling	R-HSA-9758274	9.057001e-01	0.043
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	9.057001e-01	0.043
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	9.057001e-01	0.043
Atorvastatin ADME	R-HSA-9754706	9.057001e-01	0.043
Pentose phosphate pathway	R-HSA-71336	9.073583e-01	0.042
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.095044e-01	0.041
Negative regulation of FGFR3 signaling	R-HSA-5654732	9.095044e-01	0.041
Pyroptosis	R-HSA-5620971	9.095044e-01	0.041
PI3K Cascade	R-HSA-109704	9.100940e-01	0.041
PPARA activates gene expression	R-HSA-1989781	9.113240e-01	0.040
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.117717e-01	0.040
Aggrephagy	R-HSA-9646399	9.147095e-01	0.039
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.147095e-01	0.039
Glycogen metabolism	R-HSA-8982491	9.147095e-01	0.039
Ca2+ pathway	R-HSA-4086398	9.147352e-01	0.039
Signaling by PDGF	R-HSA-186797	9.147482e-01	0.039
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.162079e-01	0.038
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.162079e-01	0.038
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.162079e-01	0.038
Phase 2 - plateau phase	R-HSA-5576893	9.162079e-01	0.038
TRAF3-dependent IRF activation pathway	R-HSA-918233	9.162079e-01	0.038
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.162079e-01	0.038
Coenzyme A biosynthesis	R-HSA-196783	9.162079e-01	0.038
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.162079e-01	0.038
tRNA modification in the mitochondrion	R-HSA-6787450	9.162079e-01	0.038
Activation of NF-kappaB in B cells	R-HSA-1169091	9.165889e-01	0.038
Meiotic recombination	R-HSA-912446	9.165889e-01	0.038
Hedgehog ligand biogenesis	R-HSA-5358346	9.165889e-01	0.038
Downstream signaling of activated FGFR3	R-HSA-5654708	9.176986e-01	0.037
Negative regulation of FGFR4 signaling	R-HSA-5654733	9.176986e-01	0.037
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.180789e-01	0.037
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.180789e-01	0.037
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.190519e-01	0.037
ER to Golgi Anterograde Transport	R-HSA-199977	9.191351e-01	0.037
Maturation of spike protein	R-HSA-9694548	9.215254e-01	0.035
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.223859e-01	0.035
RNA Polymerase I Promoter Escape	R-HSA-73772	9.226609e-01	0.035
DAP12 signaling	R-HSA-2424491	9.251910e-01	0.034
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	9.251910e-01	0.034
Downstream signaling of activated FGFR4	R-HSA-5654716	9.251910e-01	0.034
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	9.255453e-01	0.034
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.255453e-01	0.034
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	9.255453e-01	0.034
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	9.255453e-01	0.034
Regulation of FZD by ubiquitination	R-HSA-4641263	9.255453e-01	0.034
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.255453e-01	0.034
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.255453e-01	0.034
Insulin receptor signalling cascade	R-HSA-74751	9.258743e-01	0.033
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.278396e-01	0.033
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.278396e-01	0.033
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.278396e-01	0.033
Degradation of CRY and PER proteins	R-HSA-9932298	9.278396e-01	0.033
Translation of Structural Proteins	R-HSA-9683701	9.278396e-01	0.033
Amino acids regulate mTORC1	R-HSA-9639288	9.283327e-01	0.032
Regulation of PTEN stability and activity	R-HSA-8948751	9.283327e-01	0.032
Phospholipid metabolism	R-HSA-1483257	9.290483e-01	0.032
Ion channel transport	R-HSA-983712	9.296060e-01	0.032
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.320362e-01	0.031
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.320362e-01	0.031
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.320362e-01	0.031
Cargo concentration in the ER	R-HSA-5694530	9.320362e-01	0.031
Evasion by RSV of host interferon responses	R-HSA-9833109	9.320362e-01	0.031
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	9.324502e-01	0.030
tRNA processing	R-HSA-72306	9.326011e-01	0.030
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	9.338427e-01	0.030
G beta:gamma signalling through PLC beta	R-HSA-418217	9.338427e-01	0.030
Nephron development	R-HSA-9831926	9.338427e-01	0.030
Presynaptic function of Kainate receptors	R-HSA-500657	9.338427e-01	0.030
Mismatch Repair	R-HSA-5358508	9.338427e-01	0.030
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.338427e-01	0.030
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.338427e-01	0.030
Translation of Structural Proteins	R-HSA-9694635	9.345053e-01	0.029
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.362739e-01	0.029
DAG1 glycosylations	R-HSA-8931838	9.382854e-01	0.028
Inwardly rectifying K+ channels	R-HSA-1296065	9.382854e-01	0.028
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.382854e-01	0.028
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.383379e-01	0.028
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.385776e-01	0.028
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.390886e-01	0.027
Signaling by VEGF	R-HSA-194138	9.394410e-01	0.027
Cap-dependent Translation Initiation	R-HSA-72737	9.411284e-01	0.026
Eukaryotic Translation Initiation	R-HSA-72613	9.411284e-01	0.026
PI-3K cascade:FGFR3	R-HSA-5654710	9.412158e-01	0.026
IKK complex recruitment mediated by RIP1	R-HSA-937041	9.412158e-01	0.026
Translesion Synthesis by POLH	R-HSA-110320	9.412158e-01	0.026
The NLRP3 inflammasome	R-HSA-844456	9.412158e-01	0.026
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.412158e-01	0.026
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.412158e-01	0.026
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.412158e-01	0.026
Signaling by FGFR1	R-HSA-5654736	9.431634e-01	0.025
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.431634e-01	0.025
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.432701e-01	0.025
FGFR1 mutant receptor activation	R-HSA-1839124	9.439863e-01	0.025
Negative regulation of FGFR1 signaling	R-HSA-5654726	9.439863e-01	0.025
Proteasome assembly	R-HSA-9907900	9.440830e-01	0.025
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.443249e-01	0.025
Regulated Necrosis	R-HSA-5218859	9.443249e-01	0.025
Signaling by MET	R-HSA-6806834	9.465489e-01	0.024
Cellular responses to stimuli	R-HSA-8953897	9.475423e-01	0.023
PI-3K cascade:FGFR4	R-HSA-5654720	9.477676e-01	0.023
Pregnenolone biosynthesis	R-HSA-196108	9.477676e-01	0.023
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.486948e-01	0.023
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.486948e-01	0.023
Asymmetric localization of PCP proteins	R-HSA-4608870	9.486948e-01	0.023
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.486948e-01	0.023
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.486948e-01	0.023
Effects of PIP2 hydrolysis	R-HSA-114508	9.491835e-01	0.023
Vpu mediated degradation of CD4	R-HSA-180534	9.491835e-01	0.023
Glucagon signaling in metabolic regulation	R-HSA-163359	9.491835e-01	0.023
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.491835e-01	0.023
Miscellaneous transport and binding events	R-HSA-5223345	9.491835e-01	0.023
Heme degradation	R-HSA-189483	9.491835e-01	0.023
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	9.496095e-01	0.022
MyD88-independent TLR4 cascade	R-HSA-166166	9.496095e-01	0.022
Amyloid fiber formation	R-HSA-977225	9.500981e-01	0.022
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.525119e-01	0.021
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.529501e-01	0.021
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.535895e-01	0.021
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.535895e-01	0.021
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.535895e-01	0.021
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.535895e-01	0.021
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	9.535895e-01	0.021
Lagging Strand Synthesis	R-HSA-69186	9.535895e-01	0.021
Phenylalanine metabolism	R-HSA-8964208	9.535895e-01	0.021
Basigin interactions	R-HSA-210991	9.535895e-01	0.021
Early Phase of HIV Life Cycle	R-HSA-162594	9.535895e-01	0.021
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.539185e-01	0.020
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.539185e-01	0.020
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.539185e-01	0.020
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.539185e-01	0.020
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.539185e-01	0.020
Calnexin/calreticulin cycle	R-HSA-901042	9.539185e-01	0.020
NPAS4 regulates expression of target genes	R-HSA-9768919	9.539185e-01	0.020
SARS-CoV-2-host interactions	R-HSA-9705683	9.547276e-01	0.020
Extension of Telomeres	R-HSA-180786	9.551389e-01	0.020
Triglyceride metabolism	R-HSA-8979227	9.551389e-01	0.020
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.551389e-01	0.020
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.553216e-01	0.020
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.568737e-01	0.019
Downstream signaling of activated FGFR2	R-HSA-5654696	9.582296e-01	0.019
Downstream signaling of activated FGFR1	R-HSA-5654687	9.582296e-01	0.019
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.582296e-01	0.019
PERK regulates gene expression	R-HSA-381042	9.582296e-01	0.019
Regulation of Apoptosis	R-HSA-169911	9.582296e-01	0.019
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.587628e-01	0.018
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.587628e-01	0.018
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.587628e-01	0.018
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	9.587628e-01	0.018
Cellular responses to mechanical stimuli	R-HSA-9855142	9.604368e-01	0.018
GPER1 signaling	R-HSA-9634597	9.604890e-01	0.018
Collagen formation	R-HSA-1474290	9.610823e-01	0.017
GPVI-mediated activation cascade	R-HSA-114604	9.621525e-01	0.017
RSV-host interactions	R-HSA-9833110	9.629776e-01	0.016
PI-3K cascade:FGFR1	R-HSA-5654689	9.633597e-01	0.016
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.633597e-01	0.016
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.633597e-01	0.016
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.633597e-01	0.016
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.633597e-01	0.016
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.633597e-01	0.016
Ethanol oxidation	R-HSA-71384	9.633597e-01	0.016
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.633597e-01	0.016
LDL clearance	R-HSA-8964038	9.633597e-01	0.016
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.636118e-01	0.016
Signaling by NOTCH4	R-HSA-9013694	9.643003e-01	0.016
Voltage gated Potassium channels	R-HSA-1296072	9.657202e-01	0.015
NCAM1 interactions	R-HSA-419037	9.657202e-01	0.015
Collagen chain trimerization	R-HSA-8948216	9.657202e-01	0.015
Metabolism of folate and pterines	R-HSA-196757	9.657202e-01	0.015
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.674445e-01	0.014
Free fatty acids regulate insulin secretion	R-HSA-400451	9.674445e-01	0.014
Carnitine shuttle	R-HSA-200425	9.674445e-01	0.014
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.674445e-01	0.014
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.674445e-01	0.014
Syndecan interactions	R-HSA-3000170	9.674445e-01	0.014
SARS-CoV-1-host interactions	R-HSA-9692914	9.674707e-01	0.014
Regulation of T cell activation by CD28 family	R-HSA-388841	9.680534e-01	0.014
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.682281e-01	0.014
MET promotes cell motility	R-HSA-8875878	9.689631e-01	0.014
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.696989e-01	0.013
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.700495e-01	0.013
Autophagy	R-HSA-9612973	9.700523e-01	0.013
TRAF6 mediated NF-kB activation	R-HSA-933542	9.710740e-01	0.013
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.710740e-01	0.013
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.710740e-01	0.013
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.710740e-01	0.013
CD209 (DC-SIGN) signaling	R-HSA-5621575	9.710740e-01	0.013
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.710740e-01	0.013
TNFs bind their physiological receptors	R-HSA-5669034	9.710740e-01	0.013
Plasma lipoprotein assembly	R-HSA-8963898	9.710740e-01	0.013
HCMV Late Events	R-HSA-9610379	9.716677e-01	0.012
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.719093e-01	0.012
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.719093e-01	0.012
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.722884e-01	0.012
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.722884e-01	0.012
Signaling by FGFR	R-HSA-190236	9.723041e-01	0.012
Regulation of insulin secretion	R-HSA-422356	9.723041e-01	0.012
Cellular response to hypoxia	R-HSA-1234174	9.724118e-01	0.012
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.732044e-01	0.012
SLC-mediated transport of organic anions	R-HSA-9955298	9.736954e-01	0.012
PI-3K cascade:FGFR2	R-HSA-5654695	9.742991e-01	0.011
Activation of G protein gated Potassium channels	R-HSA-1296041	9.742991e-01	0.011
G protein gated Potassium channels	R-HSA-1296059	9.742991e-01	0.011
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.742991e-01	0.011
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.742991e-01	0.011
Alpha-oxidation of phytanate	R-HSA-389599	9.742991e-01	0.011
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.742991e-01	0.011
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.742991e-01	0.011
Laminin interactions	R-HSA-3000157	9.742991e-01	0.011
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.745845e-01	0.011
Diseases of Immune System	R-HSA-5260271	9.745845e-01	0.011
Interleukin-2 family signaling	R-HSA-451927	9.745845e-01	0.011
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.745987e-01	0.011
Interferon gamma signaling	R-HSA-877300	9.746657e-01	0.011
Golgi Associated Vesicle Biogenesis	R-HSA-432722	9.746671e-01	0.011
Neuronal System	R-HSA-112316	9.750350e-01	0.011
Nicotinate metabolism	R-HSA-196807	9.766220e-01	0.010
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.768510e-01	0.010
Hh mutants are degraded by ERAD	R-HSA-5362768	9.770126e-01	0.010
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.770126e-01	0.010
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.770126e-01	0.010
MET activates PTK2 signaling	R-HSA-8874081	9.771648e-01	0.010
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.771648e-01	0.010
Suppression of phagosomal maturation	R-HSA-9637687	9.771648e-01	0.010
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.771648e-01	0.010
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.771648e-01	0.010
Macroautophagy	R-HSA-1632852	9.784659e-01	0.009
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.784929e-01	0.009
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.792154e-01	0.009
RNA Polymerase I Transcription Termination	R-HSA-73863	9.797111e-01	0.009
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.797111e-01	0.009
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.797111e-01	0.009
Triglyceride biosynthesis	R-HSA-75109	9.797111e-01	0.009
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.797111e-01	0.009
Synthesis of PE	R-HSA-1483213	9.797111e-01	0.009
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.797111e-01	0.009
Signaling by Insulin receptor	R-HSA-74752	9.803782e-01	0.009
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.803782e-01	0.009
Cytosolic tRNA aminoacylation	R-HSA-379716	9.812130e-01	0.008
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	9.812130e-01	0.008
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.812130e-01	0.008
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.817896e-01	0.008
COPII-mediated vesicle transport	R-HSA-204005	9.818192e-01	0.008
Response of endothelial cells to shear stress	R-HSA-9860931	9.818245e-01	0.008
Activation of AMPK downstream of NMDARs	R-HSA-9619483	9.819736e-01	0.008
Phase 0 - rapid depolarisation	R-HSA-5576892	9.819736e-01	0.008
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.819736e-01	0.008
Prednisone ADME	R-HSA-9757110	9.819736e-01	0.008
Insulin receptor recycling	R-HSA-77387	9.819736e-01	0.008
Inflammasomes	R-HSA-622312	9.819736e-01	0.008
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.819736e-01	0.008
Pyrimidine salvage	R-HSA-73614	9.819736e-01	0.008
SARS-CoV Infections	R-HSA-9679506	9.822196e-01	0.008
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.833500e-01	0.007
Late endosomal microautophagy	R-HSA-9615710	9.839839e-01	0.007
Thyroxine biosynthesis	R-HSA-209968	9.839839e-01	0.007
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.839839e-01	0.007
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.839839e-01	0.007
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.839839e-01	0.007
SLC transporter disorders	R-HSA-5619102	9.840014e-01	0.007
Interferon alpha/beta signaling	R-HSA-909733	9.844594e-01	0.007
DAP12 interactions	R-HSA-2172127	9.846642e-01	0.007
Co-inhibition by PD-1	R-HSA-389948	9.852587e-01	0.006
Formation of a pool of free 40S subunits	R-HSA-72689	9.854757e-01	0.006
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.857701e-01	0.006
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.857701e-01	0.006
Neurotransmitter clearance	R-HSA-112311	9.857701e-01	0.006
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.861501e-01	0.006
Somitogenesis	R-HSA-9824272	9.861501e-01	0.006
GABA receptor activation	R-HSA-977443	9.866284e-01	0.006
Signaling by Retinoic Acid	R-HSA-5362517	9.866284e-01	0.006
Toll-like Receptor Cascades	R-HSA-168898	9.866710e-01	0.006
Budding and maturation of HIV virion	R-HSA-162588	9.873572e-01	0.006
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.873572e-01	0.006
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.874955e-01	0.005
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.874955e-01	0.005
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.874955e-01	0.005
Collagen degradation	R-HSA-1442490	9.878122e-01	0.005
Formation of paraxial mesoderm	R-HSA-9793380	9.878122e-01	0.005
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.881333e-01	0.005
Protein ubiquitination	R-HSA-8852135	9.881333e-01	0.005
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.887132e-01	0.005
Metal ion SLC transporters	R-HSA-425410	9.898148e-01	0.004
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.900204e-01	0.004
Defective B3GALTL causes PpS	R-HSA-5083635	9.900204e-01	0.004
Recycling of bile acids and salts	R-HSA-159418	9.900204e-01	0.004
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.900204e-01	0.004
ABC-family proteins mediated transport	R-HSA-382556	9.901073e-01	0.004
Transmission across Chemical Synapses	R-HSA-112315	9.903584e-01	0.004
HCMV Infection	R-HSA-9609646	9.905190e-01	0.004
Gap junction trafficking and regulation	R-HSA-157858	9.908113e-01	0.004
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.908113e-01	0.004
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.908113e-01	0.004
ABC transporter disorders	R-HSA-5619084	9.908519e-01	0.004
Interleukin-10 signaling	R-HSA-6783783	9.908519e-01	0.004
Acyl chain remodelling of PC	R-HSA-1482788	9.911336e-01	0.004
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.916152e-01	0.004
Hyaluronan metabolism	R-HSA-2142845	9.921228e-01	0.003
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.921228e-01	0.003
Signal amplification	R-HSA-392518	9.921228e-01	0.003
The phototransduction cascade	R-HSA-2514856	9.925266e-01	0.003
Acyl chain remodelling of PE	R-HSA-1482839	9.930016e-01	0.003
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.930016e-01	0.003
Transferrin endocytosis and recycling	R-HSA-917977	9.930016e-01	0.003
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	9.930016e-01	0.003
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.932624e-01	0.003
Beta-catenin independent WNT signaling	R-HSA-3858494	9.933513e-01	0.003
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.937387e-01	0.003
Lysosome Vesicle Biogenesis	R-HSA-432720	9.937824e-01	0.003
Platelet degranulation	R-HSA-114608	9.938438e-01	0.003
Vesicle-mediated transport	R-HSA-5653656	9.938886e-01	0.003
Platelet homeostasis	R-HSA-418346	9.943006e-01	0.002
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.944762e-01	0.002
TRAF6 mediated IRF7 activation	R-HSA-933541	9.944762e-01	0.002
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.944762e-01	0.002
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.947815e-01	0.002
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.947860e-01	0.002
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.950926e-01	0.002
Antigen processing-Cross presentation	R-HSA-1236975	9.951448e-01	0.002
SARS-CoV-2 Infection	R-HSA-9694516	9.954585e-01	0.002
SARS-CoV-1 Infection	R-HSA-9678108	9.954799e-01	0.002
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.956402e-01	0.002
Plasma lipoprotein clearance	R-HSA-8964043	9.956402e-01	0.002
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.956913e-01	0.002
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.958802e-01	0.002
Dectin-2 family	R-HSA-5621480	9.960002e-01	0.002
Synthesis of PA	R-HSA-1483166	9.960002e-01	0.002
Generation of second messenger molecules	R-HSA-202433	9.961267e-01	0.002
Chaperonin-mediated protein folding	R-HSA-390466	9.962342e-01	0.002
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.963385e-01	0.002
Transport to the Golgi and subsequent modification	R-HSA-948021	9.964892e-01	0.002
Cytokine Signaling in Immune system	R-HSA-1280215	9.965444e-01	0.002
Peptide chain elongation	R-HSA-156902	9.965595e-01	0.001
Amino acid transport across the plasma membrane	R-HSA-352230	9.967578e-01	0.001
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.967737e-01	0.001
ER-Phagosome pathway	R-HSA-1236974	9.968575e-01	0.001
Heme biosynthesis	R-HSA-189451	9.969431e-01	0.001
Interleukin-12 signaling	R-HSA-9020591	9.970717e-01	0.001
RAB geranylgeranylation	R-HSA-8873719	9.970817e-01	0.001
tRNA Aminoacylation	R-HSA-379724	9.970817e-01	0.001
Glutathione conjugation	R-HSA-156590	9.970817e-01	0.001
Metabolism of polyamines	R-HSA-351202	9.970817e-01	0.001
Downstream TCR signaling	R-HSA-202424	9.971304e-01	0.001
Activation of GABAB receptors	R-HSA-991365	9.972843e-01	0.001
GABA B receptor activation	R-HSA-977444	9.972843e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.973338e-01	0.001
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.973803e-01	0.001
Adaptive Immune System	R-HSA-1280218	9.974955e-01	0.001
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.975846e-01	0.001
Defensins	R-HSA-1461973	9.975874e-01	0.001
Response of Mtb to phagocytosis	R-HSA-9637690	9.975874e-01	0.001
PCP/CE pathway	R-HSA-4086400	9.975894e-01	0.001
Mitochondrial protein import	R-HSA-1268020	9.976370e-01	0.001
Neutrophil degranulation	R-HSA-6798695	9.978067e-01	0.001
Eukaryotic Translation Elongation	R-HSA-156842	9.978184e-01	0.001
Protein folding	R-HSA-391251	9.978184e-01	0.001
Surfactant metabolism	R-HSA-5683826	9.978567e-01	0.001
Regulation of pyruvate metabolism	R-HSA-9861718	9.983086e-01	0.001
Disorders of transmembrane transporters	R-HSA-5619115	9.983141e-01	0.001
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.983451e-01	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	9.984753e-01	0.001
Eukaryotic Translation Termination	R-HSA-72764	9.984914e-01	0.001
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.985236e-01	0.001
SLC-mediated transport of amino acids	R-HSA-9958863	9.986099e-01	0.001
Metabolism of steroid hormones	R-HSA-196071	9.986099e-01	0.001
Intraflagellar transport	R-HSA-5620924	9.986652e-01	0.001
Plasma lipoprotein remodeling	R-HSA-8963899	9.986652e-01	0.001
TCR signaling	R-HSA-202403	9.986916e-01	0.001
O-linked glycosylation of mucins	R-HSA-913709	9.987504e-01	0.001
Cellular response to starvation	R-HSA-9711097	9.987718e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.988143e-01	0.001
C-type lectin receptors (CLRs)	R-HSA-5621481	9.988952e-01	0.000
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.989025e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.989075e-01	0.000
Complex IV assembly	R-HSA-9864848	9.990643e-01	0.000
Branched-chain amino acid catabolism	R-HSA-70895	9.990643e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.990932e-01	0.000
Interleukin-12 family signaling	R-HSA-447115	9.991003e-01	0.000
Selenocysteine synthesis	R-HSA-2408557	9.991383e-01	0.000
Ribosome-associated quality control	R-HSA-9948299	9.991800e-01	0.000
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.991853e-01	0.000
Signaling by Interleukins	R-HSA-449147	9.992598e-01	0.000
Viral mRNA Translation	R-HSA-192823	9.992863e-01	0.000
Neurotransmitter release cycle	R-HSA-112310	9.993332e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.993427e-01	0.000
Iron uptake and transport	R-HSA-917937	9.994097e-01	0.000
Paracetamol ADME	R-HSA-9753281	9.994174e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.994825e-01	0.000
Digestion	R-HSA-8935690	9.994825e-01	0.000
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.995065e-01	0.000
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.995559e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.995728e-01	0.000
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.995916e-01	0.000
Neddylation	R-HSA-8951664	9.995961e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.996166e-01	0.000
Peroxisomal protein import	R-HSA-9033241	9.996373e-01	0.000
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.996744e-01	0.000
Endogenous sterols	R-HSA-211976	9.997138e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.997138e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.997742e-01	0.000
Digestion and absorption	R-HSA-8963743	9.997742e-01	0.000
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.998091e-01	0.000
rRNA processing	R-HSA-72312	9.998187e-01	0.000
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.998218e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.998304e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.998391e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998595e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.998917e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.998960e-01	0.000
Viral Infection Pathways	R-HSA-9824446	9.999060e-01	0.000
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.999078e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.999125e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.999125e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.999125e-01	0.000
Purine catabolism	R-HSA-74259	9.999223e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999303e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999310e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.999399e-01	0.000
Protein localization	R-HSA-9609507	9.999410e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999456e-01	0.000
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.999476e-01	0.000
Parasite infection	R-HSA-9664407	9.999476e-01	0.000
Leishmania phagocytosis	R-HSA-9664417	9.999476e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999477e-01	0.000
Platelet activation, signaling and aggregation	R-HSA-76002	9.999477e-01	0.000
Integrin cell surface interactions	R-HSA-216083	9.999619e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.999674e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999689e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999733e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.999786e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999813e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999840e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.999884e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999918e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999926e-01	0.000
Hemostasis	R-HSA-109582	9.999932e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.999934e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999935e-01	0.000
FCGR activation	R-HSA-2029481	9.999949e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999954e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.999958e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999962e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999968e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999970e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999971e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999974e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999981e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999983e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999983e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.999987e-01	0.000
Leishmania infection	R-HSA-9658195	9.999987e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999992e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999993e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999993e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999995e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999996e-01	0.000
Keratinization	R-HSA-6805567	9.999997e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999998e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999999e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999999e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999999e-01	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000
Post-translational protein modification	R-HSA-597592	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Immune System	R-HSA-168256	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Translation	R-HSA-72766	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Innate Immune System	R-HSA-168249	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.953959e-11	10.530
mRNA Splicing - Major Pathway	R-HSA-72163	2.335499e-08	7.632
Cell Cycle	R-HSA-1640170	2.553731e-08	7.593
mRNA Splicing	R-HSA-72172	1.034053e-07	6.985
Cell Cycle, Mitotic	R-HSA-69278	2.100485e-07	6.678
Metabolism of RNA	R-HSA-8953854	2.580733e-07	6.588
Chromatin organization	R-HSA-4839726	7.488211e-07	6.126
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	8.611573e-07	6.065
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.242812e-06	5.906
M Phase	R-HSA-68886	4.623227e-06	5.335
Chromatin modifying enzymes	R-HSA-3247509	7.204880e-06	5.142
Mitotic Anaphase	R-HSA-68882	1.106761e-05	4.956
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.225014e-05	4.912
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.473193e-05	4.832
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.197082e-05	4.658
ATP-dependent chromatin remodelers	R-HSA-9932444	5.220369e-05	4.282
SWI/SNF chromatin remodelers	R-HSA-9932451	5.220369e-05	4.282
Cell Cycle Checkpoints	R-HSA-69620	6.519472e-05	4.186
Nuclear Envelope Breakdown	R-HSA-2980766	6.667989e-05	4.176
mRNA 3'-end processing	R-HSA-72187	8.006613e-05	4.097
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	9.645481e-05	4.016
Signaling by ALK in cancer	R-HSA-9700206	9.645481e-05	4.016
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.006622e-04	3.997
Amplification of signal from the kinetochores	R-HSA-141424	1.255610e-04	3.901
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.255610e-04	3.901
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.253229e-04	3.902
RNA Polymerase II Transcription Termination	R-HSA-73856	1.383683e-04	3.859
Separation of Sister Chromatids	R-HSA-2467813	1.800941e-04	3.745
Signal Transduction	R-HSA-162582	1.841613e-04	3.735
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.001048e-04	3.699
Mitotic Spindle Checkpoint	R-HSA-69618	2.036101e-04	3.691
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.320983e-04	3.634
Apoptotic execution phase	R-HSA-75153	2.519519e-04	3.599
Cellular response to heat stress	R-HSA-3371556	2.868714e-04	3.542
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.961412e-04	3.529
Apoptosis	R-HSA-109581	3.077555e-04	3.512
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	3.465052e-04	3.460
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.410853e-04	3.467
MTOR signalling	R-HSA-165159	3.688508e-04	3.433
mTORC1-mediated signalling	R-HSA-166208	4.005214e-04	3.397
p75 NTR receptor-mediated signalling	R-HSA-193704	4.306104e-04	3.366
DNA Damage Recognition in GG-NER	R-HSA-5696394	5.212209e-04	3.283
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	5.212209e-04	3.283
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	5.402243e-04	3.267
Mitotic Prophase	R-HSA-68875	5.703881e-04	3.244
Nuclear import of Rev protein	R-HSA-180746	6.445859e-04	3.191
Interactions of Rev with host cellular proteins	R-HSA-177243	6.567189e-04	3.183
Mitotic Prometaphase	R-HSA-68877	6.718282e-04	3.173
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	6.946293e-04	3.158
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	7.265236e-04	3.139
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	7.362002e-04	3.133
Axon guidance	R-HSA-422475	9.966054e-04	3.001
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.170026e-03	2.932
Epigenetic regulation of gene expression	R-HSA-212165	1.174646e-03	2.930
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.389478e-03	2.857
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.409292e-03	2.851
NRAGE signals death through JNK	R-HSA-193648	1.376893e-03	2.861
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.420644e-03	2.848
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.420644e-03	2.848
Transcriptional regulation by RUNX1	R-HSA-8878171	1.425835e-03	2.846
Nervous system development	R-HSA-9675108	1.579470e-03	2.801
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.741174e-03	2.759
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.794330e-03	2.746
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.920747e-03	2.717
Transcriptional Regulation by TP53	R-HSA-3700989	2.295571e-03	2.639
Cell-extracellular matrix interactions	R-HSA-446353	2.419451e-03	2.616
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.436487e-03	2.613
Influenza Viral RNA Transcription and Replication	R-HSA-168273	2.534577e-03	2.596
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.554381e-03	2.593
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.804500e-03	2.552
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	2.850520e-03	2.545
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	3.094554e-03	2.509
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	3.094554e-03	2.509
MITF-M-regulated melanocyte development	R-HSA-9730414	3.188003e-03	2.496
MITF-M-dependent gene expression	R-HSA-9856651	3.210568e-03	2.493
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	3.538512e-03	2.451
Vpr-mediated nuclear import of PICs	R-HSA-180910	3.538512e-03	2.451
Cell-Cell communication	R-HSA-1500931	3.430837e-03	2.465
Oncogenic MAPK signaling	R-HSA-6802957	3.811376e-03	2.419
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	4.160077e-03	2.381
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	4.550464e-03	2.342
IPs transport between nucleus and cytosol	R-HSA-1855170	4.446159e-03	2.352
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	4.458178e-03	2.351
Transcriptional regulation by small RNAs	R-HSA-5578749	4.540789e-03	2.343
Death Receptor Signaling	R-HSA-73887	4.383795e-03	2.358
RMTs methylate histone arginines	R-HSA-3214858	4.458178e-03	2.351
Cell junction organization	R-HSA-446728	4.557885e-03	2.341
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.550464e-03	2.342
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	4.446159e-03	2.352
HATs acetylate histones	R-HSA-3214847	4.696563e-03	2.328
Transcriptional Regulation by E2F6	R-HSA-8953750	4.891565e-03	2.311
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.891565e-03	2.311
Influenza Infection	R-HSA-168255	4.904559e-03	2.309
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	4.916848e-03	2.308
DNA Repair	R-HSA-73894	5.457189e-03	2.263
Signaling by Hippo	R-HSA-2028269	5.322255e-03	2.274
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	5.276887e-03	2.278
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.924134e-03	2.227
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.939464e-03	2.226
Signaling downstream of RAS mutants	R-HSA-9649948	5.939464e-03	2.226
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.939464e-03	2.226
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.822765e-03	2.235
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	5.822765e-03	2.235
Signaling by RAS mutants	R-HSA-6802949	5.939464e-03	2.226
Interactions of Vpr with host cellular proteins	R-HSA-176033	5.706599e-03	2.244
Smooth Muscle Contraction	R-HSA-445355	6.020254e-03	2.220
Programmed Cell Death	R-HSA-5357801	5.623998e-03	2.250
ISG15 antiviral mechanism	R-HSA-1169408	6.350712e-03	2.197
Estrogen-dependent gene expression	R-HSA-9018519	6.513417e-03	2.186
PKMTs methylate histone lysines	R-HSA-3214841	6.624917e-03	2.179
Eukaryotic Translation Initiation	R-HSA-72613	7.021124e-03	2.154
Cap-dependent Translation Initiation	R-HSA-72737	7.021124e-03	2.154
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	7.725110e-03	2.112
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	7.299135e-03	2.137
MAP2K and MAPK activation	R-HSA-5674135	7.655028e-03	2.116
Signaling by RAF1 mutants	R-HSA-9656223	7.655028e-03	2.116
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	7.458574e-03	2.127
Activation of BH3-only proteins	R-HSA-114452	7.898412e-03	2.102
Gene expression (Transcription)	R-HSA-74160	9.090971e-03	2.041
Eukaryotic Translation Elongation	R-HSA-156842	9.352854e-03	2.029
G2/M Checkpoints	R-HSA-69481	9.660046e-03	2.015
Regulation of CDH1 Function	R-HSA-9764561	9.853674e-03	2.006
DCC mediated attractive signaling	R-HSA-418885	9.890166e-03	2.005
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	9.994399e-03	2.000
Regulation of CDH1 Expression and Function	R-HSA-9764265	9.994399e-03	2.000
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.015321e-02	1.993
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.064127e-02	1.973
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.086615e-02	1.964
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.187625e-02	1.925
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.105920e-02	1.956
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.124928e-02	1.949
Metalloprotease DUBs	R-HSA-5689901	1.187625e-02	1.925
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.214139e-02	1.916
Regulation of endogenous retroelements	R-HSA-9842860	1.233109e-02	1.909
snRNP Assembly	R-HSA-191859	1.237615e-02	1.907
Metabolism of non-coding RNA	R-HSA-194441	1.237615e-02	1.907
Regulation of MECP2 expression and activity	R-HSA-9022692	1.274311e-02	1.895
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.306947e-02	1.884
Meiotic synapsis	R-HSA-1221632	1.437863e-02	1.842
Formation of a pool of free 40S subunits	R-HSA-72689	1.332095e-02	1.875
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.409046e-02	1.851
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.398306e-02	1.854
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.402885e-02	1.853
Signaling by ROBO receptors	R-HSA-376176	1.313073e-02	1.882
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.306947e-02	1.884
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.450315e-02	1.839
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.476694e-02	1.831
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.479146e-02	1.830
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.554603e-02	1.808
Diseases of Telomere Maintenance	R-HSA-9673013	1.554603e-02	1.808
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.554603e-02	1.808
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.554603e-02	1.808
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.554603e-02	1.808
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.554603e-02	1.808
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.554603e-02	1.808
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.540336e-02	1.812
RUNX3 regulates WNT signaling	R-HSA-8951430	1.540336e-02	1.812
Cohesin Loading onto Chromatin	R-HSA-2470946	1.540336e-02	1.812
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.545430e-02	1.811
Translation initiation complex formation	R-HSA-72649	1.609559e-02	1.793
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.562840e-02	1.806
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.562840e-02	1.806
Protein-protein interactions at synapses	R-HSA-6794362	1.689792e-02	1.772
Cellular responses to stress	R-HSA-2262752	1.590430e-02	1.798
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.702996e-02	1.769
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.773956e-02	1.751
G alpha (12/13) signalling events	R-HSA-416482	1.818543e-02	1.740
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.874051e-02	1.727
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.874051e-02	1.727
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.959391e-02	1.708
Ribosomal scanning and start codon recognition	R-HSA-72702	1.998809e-02	1.699
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.998809e-02	1.699
Regulation of TP53 Activity	R-HSA-5633007	2.036195e-02	1.691
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.098036e-02	1.678
DNA Double-Strand Break Repair	R-HSA-5693532	2.235735e-02	1.651
Peptide chain elongation	R-HSA-156902	2.371379e-02	1.625
G2/M DNA damage checkpoint	R-HSA-69473	2.563837e-02	1.591
rRNA processing in the nucleus and cytosol	R-HSA-8868773	2.424158e-02	1.615
Membrane Trafficking	R-HSA-199991	2.425953e-02	1.615
Host Interactions of HIV factors	R-HSA-162909	2.360552e-02	1.627
Mitotic G2-G2/M phases	R-HSA-453274	2.424158e-02	1.615
Cellular responses to stimuli	R-HSA-8953897	2.525218e-02	1.598
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.329018e-02	1.633
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.490366e-02	1.604
Neurodegenerative Diseases	R-HSA-8863678	2.490366e-02	1.604
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	2.551662e-02	1.593
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.374353e-02	1.624
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.703607e-02	1.568
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.765113e-02	1.558
GP1b-IX-V activation signalling	R-HSA-430116	2.765113e-02	1.558
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.765113e-02	1.558
Unwinding of DNA	R-HSA-176974	2.765113e-02	1.558
Neurexins and neuroligins	R-HSA-6794361	2.890296e-02	1.539
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.906867e-02	1.537
NrCAM interactions	R-HSA-447038	2.906867e-02	1.537
Diseases of mitotic cell cycle	R-HSA-9675126	2.918773e-02	1.535
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	2.981159e-02	1.526
UCH proteinases	R-HSA-5689603	3.044678e-02	1.516
Interleukin-12 signaling	R-HSA-9020591	3.044678e-02	1.516
Nucleotide Excision Repair	R-HSA-5696398	3.117039e-02	1.506
Regulation of TP53 Expression and Degradation	R-HSA-6806003	3.213560e-02	1.493
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	3.239037e-02	1.490
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.241841e-02	1.489
Viral Messenger RNA Synthesis	R-HSA-168325	3.273270e-02	1.485
Breakdown of the nuclear lamina	R-HSA-352238	3.290070e-02	1.483
mRNA Splicing - Minor Pathway	R-HSA-72165	3.407148e-02	1.468
Folding of actin by CCT/TriC	R-HSA-390450	3.545092e-02	1.450
Josephin domain DUBs	R-HSA-5689877	3.545092e-02	1.450
Aggrephagy	R-HSA-9646399	3.601375e-02	1.444
Negative feedback regulation of MAPK pathway	R-HSA-5674499	4.055289e-02	1.392
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	4.055289e-02	1.392
Interaction between L1 and Ankyrins	R-HSA-445095	3.844563e-02	1.415
Recycling pathway of L1	R-HSA-437239	3.777374e-02	1.423
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	4.055289e-02	1.392
L1CAM interactions	R-HSA-373760	4.207976e-02	1.376
Cell-cell junction organization	R-HSA-421270	3.988430e-02	1.399
Glycolysis	R-HSA-70171	3.670321e-02	1.435
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	4.210656e-02	1.376
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.439713e-02	1.353
Developmental Cell Lineages	R-HSA-9734767	4.492015e-02	1.348
RNA Polymerase II Transcription	R-HSA-73857	4.493908e-02	1.347
Adherens junctions interactions	R-HSA-418990	4.620830e-02	1.335
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	4.633972e-02	1.334
Eukaryotic Translation Termination	R-HSA-72764	4.633972e-02	1.334
SARS-CoV-2-host interactions	R-HSA-9705683	4.806371e-02	1.318
COPI-mediated anterograde transport	R-HSA-6807878	4.956487e-02	1.305
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.973230e-02	1.303
Disorders of Developmental Biology	R-HSA-9675151	4.991494e-02	1.302
Processing of Intronless Pre-mRNAs	R-HSA-77595	4.991494e-02	1.302
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	4.991494e-02	1.302
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	5.504328e-02	1.259
Regulation of TP53 Expression	R-HSA-6804754	5.504328e-02	1.259
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	5.504328e-02	1.259
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	5.504328e-02	1.259
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	5.504328e-02	1.259
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	5.504328e-02	1.259
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	5.504328e-02	1.259
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	5.504328e-02	1.259
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	R-HSA-1299308	5.504328e-02	1.259
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	5.504328e-02	1.259
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	5.504328e-02	1.259
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	5.504328e-02	1.259
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	5.504328e-02	1.259
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	5.091721e-02	1.293
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	5.828022e-02	1.234
HSF1-dependent transactivation	R-HSA-3371571	5.533814e-02	1.257
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.074839e-02	1.295
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	5.524364e-02	1.258
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	5.467322e-02	1.262
Transcriptional Regulation by MECP2	R-HSA-8986944	5.467322e-02	1.262
DNA Double Strand Break Response	R-HSA-5693606	5.463573e-02	1.263
Meiosis	R-HSA-1500620	6.035526e-02	1.219
Regulation of TP53 Degradation	R-HSA-6804757	5.299292e-02	1.276
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.828022e-02	1.234
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	5.630943e-02	1.249
G2/M Transition	R-HSA-69275	5.345206e-02	1.272
Netrin-1 signaling	R-HSA-373752	6.019575e-02	1.220
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	5.828022e-02	1.234
Developmental Biology	R-HSA-1266738	6.120752e-02	1.213
EPH-Ephrin signaling	R-HSA-2682334	6.240710e-02	1.205
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	6.291899e-02	1.201
Ribosome-associated quality control	R-HSA-9948299	6.440628e-02	1.191
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.571651e-02	1.182
Pervasive developmental disorders	R-HSA-9005895	6.571651e-02	1.182
Disorders of Nervous System Development	R-HSA-9697154	6.571651e-02	1.182
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	6.603611e-02	1.180
Nucleosome assembly	R-HSA-774815	6.603611e-02	1.180
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	6.624675e-02	1.179
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	6.624675e-02	1.179
VEGFA-VEGFR2 Pathway	R-HSA-4420097	6.627284e-02	1.179
Assembly of the pre-replicative complex	R-HSA-68867	6.653813e-02	1.177
Deubiquitination	R-HSA-5688426	6.783950e-02	1.169
Disinhibition of SNARE formation	R-HSA-114516	6.925864e-02	1.160
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	6.925864e-02	1.160
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.925864e-02	1.160
G0 and Early G1	R-HSA-1538133	7.023790e-02	1.153
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.028879e-02	1.153
tRNA processing in the nucleus	R-HSA-6784531	7.028879e-02	1.153
HIV Life Cycle	R-HSA-162587	7.123420e-02	1.147
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	8.097796e-02	1.092
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	8.097796e-02	1.092
MET interacts with TNS proteins	R-HSA-8875513	8.097796e-02	1.092
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	8.097796e-02	1.092
Type I hemidesmosome assembly	R-HSA-446107	8.624973e-02	1.064
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	8.624973e-02	1.064
Signaling by MRAS-complex mutants	R-HSA-9660537	8.624973e-02	1.064
Formation of annular gap junctions	R-HSA-196025	8.624973e-02	1.064
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	8.624973e-02	1.064
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	7.804714e-02	1.108
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	7.809271e-02	1.107
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.398672e-02	1.076
Striated Muscle Contraction	R-HSA-390522	8.633184e-02	1.064
Formation of Incision Complex in GG-NER	R-HSA-5696395	7.907673e-02	1.102
Inhibition of DNA recombination at telomere	R-HSA-9670095	7.907673e-02	1.102
HDACs deacetylate histones	R-HSA-3214815	7.756881e-02	1.110
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	7.533908e-02	1.123
Integrin signaling	R-HSA-354192	7.804266e-02	1.108
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	7.194970e-02	1.143
Specification of the neural plate border	R-HSA-9834899	7.809271e-02	1.107
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	7.374928e-02	1.132
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	8.486946e-02	1.071
Negative regulation of MET activity	R-HSA-6807004	8.904411e-02	1.050
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.907673e-02	1.102
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	8.398672e-02	1.076
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	8.097796e-02	1.092
Selective autophagy	R-HSA-9663891	7.847776e-02	1.105
Frs2-mediated activation	R-HSA-170968	7.804714e-02	1.108
Transcriptional Regulation by VENTX	R-HSA-8853884	8.660916e-02	1.062
Oxidative Stress Induced Senescence	R-HSA-2559580	7.224481e-02	1.141
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	8.904411e-02	1.050
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	8.097796e-02	1.092
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	7.804714e-02	1.108
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	7.804714e-02	1.108
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.222124e-02	1.141
Interleukin-12 family signaling	R-HSA-447115	7.365202e-02	1.133
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	8.956827e-02	1.048
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	8.956827e-02	1.048
Loss of Function of TP53 in Cancer	R-HSA-9723907	8.956827e-02	1.048
Signaling by TGF-beta Receptor Complex	R-HSA-170834	8.991117e-02	1.046
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.374902e-02	1.028
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.510167e-02	1.022
HIV Infection	R-HSA-162906	9.632535e-02	1.016
ESR-mediated signaling	R-HSA-8939211	9.832221e-02	1.007
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.009336e-01	0.996
Gene Silencing by RNA	R-HSA-211000	1.009336e-01	0.996
TCF dependent signaling in response to WNT	R-HSA-201681	1.033472e-01	0.986
HIV elongation arrest and recovery	R-HSA-167287	1.040929e-01	0.983
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.040929e-01	0.983
Pausing and recovery of HIV elongation	R-HSA-167290	1.040929e-01	0.983
Inactivation of CDC42 and RAC1	R-HSA-428543	1.048082e-01	0.980
Gap junction degradation	R-HSA-190873	1.048082e-01	0.980
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.048082e-01	0.980
WNT mediated activation of DVL	R-HSA-201688	1.048082e-01	0.980
Calcineurin activates NFAT	R-HSA-2025928	1.048082e-01	0.980
ALK mutants bind TKIs	R-HSA-9700645	1.048082e-01	0.980
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.048082e-01	0.980
Activation of BAD and translocation to mitochondria	R-HSA-111447	1.058523e-01	0.975
Spry regulation of FGF signaling	R-HSA-1295596	1.058523e-01	0.975
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.058523e-01	0.975
S Phase	R-HSA-69242	1.082602e-01	0.966
Regulation of gap junction activity	R-HSA-191650	1.098487e-01	0.959
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.098487e-01	0.959
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.098487e-01	0.959
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.098487e-01	0.959
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	1.098487e-01	0.959
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	1.409223e-01	0.851
IRS activation	R-HSA-74713	1.409223e-01	0.851
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.409223e-01	0.851
G2 Phase	R-HSA-68911	1.409223e-01	0.851
FLT3 signaling by CBL mutants	R-HSA-9706377	1.409223e-01	0.851
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.409223e-01	0.851
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.247732e-01	0.904
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.247732e-01	0.904
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.247732e-01	0.904
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.212179e-01	0.916
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.212179e-01	0.916
HSF1 activation	R-HSA-3371511	1.140569e-01	0.943
EGFR downregulation	R-HSA-182971	1.384572e-01	0.859
Formation of RNA Pol II elongation complex	R-HSA-112382	1.166036e-01	0.933
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.251933e-01	0.902
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	1.147545e-01	0.940
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.364913e-01	0.865
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.364913e-01	0.865
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.459953e-01	0.836
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.311035e-01	0.882
Viral mRNA Translation	R-HSA-192823	1.240540e-01	0.906
Stabilization of p53	R-HSA-69541	1.458737e-01	0.836
Downregulation of ERBB2 signaling	R-HSA-8863795	1.264655e-01	0.898
Circadian clock	R-HSA-9909396	1.101933e-01	0.958
Chromosome Maintenance	R-HSA-73886	1.406096e-01	0.852
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.302394e-01	0.885
Pexophagy	R-HSA-9664873	1.247732e-01	0.904
Chaperonin-mediated protein folding	R-HSA-390466	1.241572e-01	0.906
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.307958e-01	0.883
Activation of NOXA and translocation to mitochondria	R-HSA-111448	1.098487e-01	0.959
Regulation of CDH11 function	R-HSA-9762292	1.247732e-01	0.904
Homology Directed Repair	R-HSA-5693538	1.226831e-01	0.911
Late Phase of HIV Life Cycle	R-HSA-162599	1.244126e-01	0.905
Golgi-to-ER retrograde transport	R-HSA-8856688	1.101933e-01	0.958
Switching of origins to a post-replicative state	R-HSA-69052	1.459953e-01	0.836
Pyrophosphate hydrolysis	R-HSA-71737	1.409223e-01	0.851
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.264655e-01	0.898
Cellular Senescence	R-HSA-2559583	1.319380e-01	0.880
Macroautophagy	R-HSA-1632852	1.141960e-01	0.942
Regulation of PTEN gene transcription	R-HSA-8943724	1.121592e-01	0.950
Prolonged ERK activation events	R-HSA-169893	1.212179e-01	0.916
Signaling by VEGF	R-HSA-194138	1.162400e-01	0.935
Heme signaling	R-HSA-9707616	1.280905e-01	0.892
DAG and IP3 signaling	R-HSA-1489509	1.302394e-01	0.885
Kinesins	R-HSA-983189	1.121592e-01	0.950
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	1.098487e-01	0.959
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.341113e-01	0.873
Semaphorin interactions	R-HSA-373755	1.364913e-01	0.865
Selenocysteine synthesis	R-HSA-2408557	1.119331e-01	0.951
Diseases of programmed cell death	R-HSA-9645723	1.311035e-01	0.882
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.279590e-01	0.893
ChREBP activates metabolic gene expression	R-HSA-163765	1.459774e-01	0.836
Glucose metabolism	R-HSA-70326	1.170236e-01	0.932
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.464258e-01	0.834
Autophagy	R-HSA-9612973	1.496530e-01	0.825
DNA strand elongation	R-HSA-69190	1.509565e-01	0.821
Reproduction	R-HSA-1474165	1.510913e-01	0.821
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.711189e-01	0.767
TICAM1 deficiency - HSE	R-HSA-5602566	1.711189e-01	0.767
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.711189e-01	0.767
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	1.711189e-01	0.767
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	1.711189e-01	0.767
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.711189e-01	0.767
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	R-HSA-73930	2.453691e-01	0.610
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	2.453691e-01	0.610
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.453691e-01	0.610
TRAF3 deficiency - HSE	R-HSA-5602571	2.453691e-01	0.610
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.453691e-01	0.610
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.453691e-01	0.610
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	1.735731e-01	0.761
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.735731e-01	0.761
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.735731e-01	0.761
Noncanonical activation of NOTCH3	R-HSA-9017802	1.735731e-01	0.761
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.129721e-01	0.504
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.129721e-01	0.504
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.129721e-01	0.504
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.129721e-01	0.504
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.072698e-01	0.683
Activation of RAC1	R-HSA-428540	1.682511e-01	0.774
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.682511e-01	0.774
MECP2 regulates transcription factors	R-HSA-9022707	2.415634e-01	0.617
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.415634e-01	0.617
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.415634e-01	0.617
SOS-mediated signalling	R-HSA-112412	2.415634e-01	0.617
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	2.415634e-01	0.617
Defective MMACHC causes MAHCC	R-HSA-3359474	3.745226e-01	0.427
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.745226e-01	0.427
Invadopodia formation	R-HSA-8941237	3.745226e-01	0.427
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.745226e-01	0.427
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	3.745226e-01	0.427
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.914261e-01	0.718
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.914261e-01	0.718
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.914261e-01	0.718
Repression of WNT target genes	R-HSA-4641265	1.914261e-01	0.718
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.914261e-01	0.718
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	1.545494e-01	0.811
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.545494e-01	0.811
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.545494e-01	0.811
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.760771e-01	0.559
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.153385e-01	0.667
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.153385e-01	0.667
Ephrin signaling	R-HSA-3928664	1.723692e-01	0.764
Deadenylation of mRNA	R-HSA-429947	1.544948e-01	0.811
Regulation of signaling by CBL	R-HSA-912631	1.908560e-01	0.719
Lipophagy	R-HSA-9613354	3.104964e-01	0.508
Interleukin-21 signaling	R-HSA-9020958	3.104964e-01	0.508
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	3.104964e-01	0.508
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.305621e-01	0.366
TNFR1-mediated ceramide production	R-HSA-5626978	4.305621e-01	0.366
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.305621e-01	0.366
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.305621e-01	0.366
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.305621e-01	0.366
Signaling by MAP2K mutants	R-HSA-9652169	4.305621e-01	0.366
VxPx cargo-targeting to cilium	R-HSA-5620916	2.099305e-01	0.678
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.647527e-01	0.577
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.647527e-01	0.577
Basigin interactions	R-HSA-210991	2.295131e-01	0.639
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.295131e-01	0.639
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	3.445615e-01	0.463
EPHA-mediated growth cone collapse	R-HSA-3928663	2.010441e-01	0.697
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.010441e-01	0.697
Packaging Of Telomere Ends	R-HSA-171306	2.010441e-01	0.697
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.010441e-01	0.697
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	2.899644e-01	0.538
Attenuation phase	R-HSA-3371568	1.573270e-01	0.803
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	2.495247e-01	0.603
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.175165e-01	0.663
Formation of the Early Elongation Complex	R-HSA-113418	2.175165e-01	0.663
RAF activation	R-HSA-5673000	1.912424e-01	0.718
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.912424e-01	0.718
DNA methylation	R-HSA-5334118	2.343880e-01	0.630
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	2.698873e-01	0.569
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.153348e-01	0.501
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.780599e-01	0.422
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	2.201344e-01	0.657
PRC2 methylates histones and DNA	R-HSA-212300	2.201344e-01	0.657
Activation of the pre-replicative complex	R-HSA-68962	2.516100e-01	0.599
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.516100e-01	0.599
SIRT1 negatively regulates rRNA expression	R-HSA-427359	2.350975e-01	0.629
AURKA Activation by TPX2	R-HSA-8854518	1.633658e-01	0.787
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	2.691342e-01	0.570
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	4.108198e-01	0.386
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.108198e-01	0.386
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	4.108198e-01	0.386
Centrosome maturation	R-HSA-380287	1.631225e-01	0.787
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.186374e-01	0.660
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.660800e-01	0.436
Tight junction interactions	R-HSA-420029	3.323336e-01	0.478
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	2.028180e-01	0.693
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.816601e-01	0.550
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.912451e-01	0.408
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.912451e-01	0.408
RUNX3 regulates p14-ARF	R-HSA-8951936	4.427047e-01	0.354
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	3.412969e-01	0.467
Dual Incision in GG-NER	R-HSA-5696400	3.412969e-01	0.467
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.744001e-01	0.427
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	2.570878e-01	0.590
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	3.300308e-01	0.481
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	4.161491e-01	0.381
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	4.161491e-01	0.381
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	4.161491e-01	0.381
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	4.161491e-01	0.381
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	4.161491e-01	0.381
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.879132e-01	0.541
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	3.343902e-01	0.476
HCMV Early Events	R-HSA-9609690	1.651640e-01	0.782
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	3.493517e-01	0.457
Impaired BRCA2 binding to RAD51	R-HSA-9709570	4.162308e-01	0.381
Transcriptional regulation by RUNX3	R-HSA-8878159	3.182269e-01	0.497
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	3.794583e-01	0.421
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	3.958146e-01	0.403
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	3.958146e-01	0.403
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	3.945565e-01	0.404
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.122855e-01	0.385
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	4.122855e-01	0.385
Regulation of RUNX3 expression and activity	R-HSA-8941858	4.508804e-01	0.346
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	4.012518e-01	0.397
Protein ubiquitination	R-HSA-8852135	2.570878e-01	0.590
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.835067e-01	0.547
RNA Polymerase III Transcription	R-HSA-74158	2.201344e-01	0.657
Signaling by ERBB2	R-HSA-1227986	1.940530e-01	0.712
Ub-specific processing proteases	R-HSA-5689880	3.499788e-01	0.456
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.220032e-01	0.375
Processing of DNA double-strand break ends	R-HSA-5693607	2.199405e-01	0.658
Adipogenesis	R-HSA-9843745	3.098348e-01	0.509
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.622725e-01	0.790
HIV Transcription Elongation	R-HSA-167169	4.508804e-01	0.346
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.660800e-01	0.436
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	2.816601e-01	0.550
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	2.816601e-01	0.550
RNA Polymerase III Transcription Initiation	R-HSA-76046	2.516100e-01	0.599
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.385019e-01	0.470
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.385019e-01	0.470
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.723692e-01	0.764
MET promotes cell motility	R-HSA-8875878	4.146065e-01	0.382
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.488214e-01	0.348
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.385019e-01	0.470
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	3.533669e-01	0.452
Transcriptional regulation of testis differentiation	R-HSA-9690406	3.153348e-01	0.501
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.254046e-01	0.647
Telomere Maintenance	R-HSA-157579	3.182269e-01	0.497
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.914261e-01	0.718
TGFBR3 expression	R-HSA-9839394	1.694871e-01	0.771
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.912424e-01	0.718
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.508804e-01	0.346
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	4.108198e-01	0.386
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.976272e-01	0.526
Degradation of DVL	R-HSA-4641258	2.350975e-01	0.629
Asymmetric localization of PCP proteins	R-HSA-4608870	3.793242e-01	0.421
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.369208e-01	0.360
DNA Damage Bypass	R-HSA-73893	2.901641e-01	0.537
EPHB-mediated forward signaling	R-HSA-3928662	2.201360e-01	0.657
Nephrin family interactions	R-HSA-373753	4.161491e-01	0.381
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	3.744001e-01	0.427
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.647527e-01	0.577
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	3.113638e-01	0.507
Mismatch Repair	R-HSA-5358508	1.723692e-01	0.764
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.458521e-01	0.609
G1 Phase	R-HSA-69236	3.628433e-01	0.440
Cyclin D associated events in G1	R-HSA-69231	3.628433e-01	0.440
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	1.682511e-01	0.774
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.398306e-01	0.620
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	3.104964e-01	0.508
PI3K/AKT activation	R-HSA-198203	3.445615e-01	0.463
MET activates RAP1 and RAC1	R-HSA-8875555	3.445615e-01	0.463
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.899644e-01	0.538
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	1.912424e-01	0.718
Regulation of Apoptosis	R-HSA-169911	2.055053e-01	0.687
Elevation of cytosolic Ca2+ levels	R-HSA-139853	3.407433e-01	0.468
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.869121e-01	0.542
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.328053e-01	0.364
Chaperone Mediated Autophagy	R-HSA-9613829	1.723692e-01	0.764
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.939856e-01	0.712
Myogenesis	R-HSA-525793	1.850187e-01	0.733
Protein folding	R-HSA-391251	1.689576e-01	0.772
Termination of translesion DNA synthesis	R-HSA-5656169	4.162308e-01	0.381
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.901641e-01	0.537
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.901641e-01	0.537
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.495247e-01	0.603
Resolution of D-Loop Structures	R-HSA-5693537	3.230397e-01	0.491
Release of apoptotic factors from the mitochondria	R-HSA-111457	1.735731e-01	0.761
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.914261e-01	0.718
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.647527e-01	0.577
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.201344e-01	0.657
Orc1 removal from chromatin	R-HSA-68949	2.065144e-01	0.685
NF-kB is activated and signals survival	R-HSA-209560	4.108198e-01	0.386
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	3.048962e-01	0.516
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.114505e-01	0.675
Activation of HOX genes during differentiation	R-HSA-5619507	2.074504e-01	0.683
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.074504e-01	0.683
Specification of primordial germ cells	R-HSA-9827857	1.545494e-01	0.811
Interleukin-2 signaling	R-HSA-9020558	3.780599e-01	0.422
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	3.533669e-01	0.452
PTEN Regulation	R-HSA-6807070	3.009633e-01	0.521
Signal transduction by L1	R-HSA-445144	2.099305e-01	0.678
G1/S Transition	R-HSA-69206	4.420437e-01	0.355
NoRC negatively regulates rRNA expression	R-HSA-427413	2.132671e-01	0.671
Clathrin-mediated endocytosis	R-HSA-8856828	1.871274e-01	0.728
RNA Polymerase I Transcription	R-HSA-73864	2.917454e-01	0.535
Gap junction trafficking and regulation	R-HSA-157858	2.901641e-01	0.537
Generation of second messenger molecules	R-HSA-202433	2.816601e-01	0.550
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.162333e-01	0.665
Meiotic recombination	R-HSA-912446	3.195221e-01	0.495
RNA Polymerase I Promoter Clearance	R-HSA-73854	3.909442e-01	0.408
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.055053e-01	0.687
Transport of connexons to the plasma membrane	R-HSA-190872	1.723692e-01	0.764
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.398306e-01	0.620
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.153348e-01	0.501
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.407433e-01	0.468
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.048962e-01	0.516
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.695281e-01	0.569
Post-chaperonin tubulin folding pathway	R-HSA-389977	4.161491e-01	0.381
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.407127e-01	0.356
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.371225e-01	0.472
Fanconi Anemia Pathway	R-HSA-6783310	3.793242e-01	0.421
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.369208e-01	0.360
PCP/CE pathway	R-HSA-4086400	4.172033e-01	0.380
DNA Replication Pre-Initiation	R-HSA-69002	1.721218e-01	0.764
Gap junction trafficking	R-HSA-190828	3.628433e-01	0.440
Signaling by WNT	R-HSA-195721	2.441209e-01	0.612
Intracellular signaling by second messengers	R-HSA-9006925	3.853338e-01	0.414
G1/S DNA Damage Checkpoints	R-HSA-69615	3.509784e-01	0.455
Oncogene Induced Senescence	R-HSA-2559585	2.055053e-01	0.687
Synthesis of DNA	R-HSA-69239	3.292739e-01	0.482
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	2.647527e-01	0.577
HDR through Homologous Recombination (HRR)	R-HSA-5685942	4.068876e-01	0.391
Signaling by Nuclear Receptors	R-HSA-9006931	4.516783e-01	0.345
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.533669e-01	0.452
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.875877e-01	0.727
Generic Transcription Pathway	R-HSA-212436	2.448685e-01	0.611
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.305621e-01	0.366
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.305621e-01	0.366
Deadenylation-dependent mRNA decay	R-HSA-429914	4.397632e-01	0.357
TCR signaling	R-HSA-202403	3.609019e-01	0.443
Hedgehog 'off' state	R-HSA-5610787	3.510892e-01	0.455
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.614763e-01	0.583
Beta-catenin independent WNT signaling	R-HSA-3858494	3.659916e-01	0.437
Amyloid fiber formation	R-HSA-977225	2.199405e-01	0.658
Rap1 signalling	R-HSA-392517	1.908560e-01	0.719
NRIF signals cell death from the nucleus	R-HSA-205043	2.398306e-01	0.620
Apoptotic factor-mediated response	R-HSA-111471	3.660800e-01	0.436
Negative regulation of FGFR3 signaling	R-HSA-5654732	3.953733e-01	0.403
Negative regulation of FGFR4 signaling	R-HSA-5654733	4.162308e-01	0.381
Cellular response to starvation	R-HSA-9711097	2.243525e-01	0.649
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.794583e-01	0.421
RAF/MAP kinase cascade	R-HSA-5673001	2.499842e-01	0.602
Effects of PIP2 hydrolysis	R-HSA-114508	1.773768e-01	0.751
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.633658e-01	0.787
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.108198e-01	0.386
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	2.905248e-01	0.537
MAPK1/MAPK3 signaling	R-HSA-5684996	2.912622e-01	0.536
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	3.912451e-01	0.408
Vesicle-mediated transport	R-HSA-5653656	3.277099e-01	0.485
Interleukin-7 signaling	R-HSA-1266695	1.694871e-01	0.771
p75NTR signals via NF-kB	R-HSA-193639	2.647527e-01	0.577
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.074363e-01	0.512
Negative regulation of MAPK pathway	R-HSA-5675221	3.137618e-01	0.503
DNA Replication	R-HSA-69306	4.385770e-01	0.358
Transport of connexins along the secretory pathway	R-HSA-190827	2.453691e-01	0.610
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.453691e-01	0.610
Regulation of cortical dendrite branching	R-HSA-8985801	3.129721e-01	0.504
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.129721e-01	0.504
Regulation of PTEN localization	R-HSA-8948747	2.415634e-01	0.617
Activation of BIM and translocation to mitochondria	R-HSA-111446	3.745226e-01	0.427
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.760771e-01	0.559
Synaptic adhesion-like molecules	R-HSA-8849932	1.723692e-01	0.764
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.305621e-01	0.366
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.647527e-01	0.577
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.647527e-01	0.577
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	2.698873e-01	0.569
Ionotropic activity of kainate receptors	R-HSA-451306	3.780599e-01	0.422
Bicarbonate transporters	R-HSA-425381	3.780599e-01	0.422
Regulation of IFNG signaling	R-HSA-877312	4.427047e-01	0.354
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.427047e-01	0.354
RNA Polymerase I Promoter Opening	R-HSA-73728	3.744001e-01	0.427
Negative regulation of NOTCH4 signaling	R-HSA-9604323	4.508804e-01	0.346
Degradation of CDH1	R-HSA-9766229	4.450595e-01	0.352
Platelet activation, signaling and aggregation	R-HSA-76002	2.219386e-01	0.654
MAPK family signaling cascades	R-HSA-5683057	1.894467e-01	0.723
Nuclear RNA decay	R-HSA-9930044	3.048962e-01	0.516
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.976272e-01	0.526
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.881829e-01	0.540
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.488214e-01	0.348
ER to Golgi Anterograde Transport	R-HSA-199977	1.522532e-01	0.817
Signaling by EGFR	R-HSA-177929	3.945565e-01	0.404
Regulation of NF-kappa B signaling	R-HSA-9758274	2.899644e-01	0.538
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	3.533669e-01	0.452
rRNA processing	R-HSA-72312	1.568820e-01	0.804
p75NTR recruits signalling complexes	R-HSA-209543	1.914261e-01	0.718
Activation of ATR in response to replication stress	R-HSA-176187	3.048962e-01	0.516
The NLRP3 inflammasome	R-HSA-844456	3.912451e-01	0.408
Base Excision Repair	R-HSA-73884	3.285727e-01	0.483
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.953733e-01	0.403
Early Phase of HIV Life Cycle	R-HSA-162594	4.407127e-01	0.356
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	2.069042e-01	0.684
Signaling by MET	R-HSA-6806834	2.099490e-01	0.678
Signal attenuation	R-HSA-74749	3.445615e-01	0.463
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.162308e-01	0.381
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.416436e-01	0.617
Post NMDA receptor activation events	R-HSA-438064	2.946092e-01	0.531
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.733101e-01	0.428
Uptake and function of diphtheria toxin	R-HSA-5336415	2.415634e-01	0.617
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.104964e-01	0.508
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	3.780599e-01	0.422
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.564825e-01	0.591
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.445615e-01	0.463
Nuclear signaling by ERBB4	R-HSA-1251985	1.573270e-01	0.803
Regulation of KIT signaling	R-HSA-1433559	2.398306e-01	0.620
Interleukin-1 signaling	R-HSA-9020702	3.621748e-01	0.441
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.387806e-01	0.470
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	3.793242e-01	0.421
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	3.793242e-01	0.421
Signaling by NOTCH1	R-HSA-1980143	3.909442e-01	0.408
Signaling by TGFB family members	R-HSA-9006936	1.732851e-01	0.761
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.132671e-01	0.671
Signaling by NOTCH4	R-HSA-9013694	2.458521e-01	0.609
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.552188e-01	0.809
Calmodulin induced events	R-HSA-111933	2.201344e-01	0.657
Signaling by TGFBR3	R-HSA-9839373	3.958146e-01	0.403
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.131220e-01	0.504
Muscle contraction	R-HSA-397014	3.432687e-01	0.464
Signaling by NOTCH	R-HSA-157118	3.988287e-01	0.399
Oligomerization of connexins into connexons	R-HSA-190704	2.453691e-01	0.610
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.735731e-01	0.761
ARMS-mediated activation	R-HSA-170984	3.104964e-01	0.508
NADE modulates death signalling	R-HSA-205025	4.305621e-01	0.366
Regulation of the apoptosome activity	R-HSA-9627069	3.445615e-01	0.463
Negative regulation of FLT3	R-HSA-9706369	2.899644e-01	0.538
CaM pathway	R-HSA-111997	2.201344e-01	0.657
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.350975e-01	0.629
Diseases of DNA repair	R-HSA-9675135	3.958146e-01	0.403
RUNX2 regulates bone development	R-HSA-8941326	3.779779e-01	0.423
Sema4D in semaphorin signaling	R-HSA-400685	1.694871e-01	0.771
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.814025e-01	0.741
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.501212e-01	0.602
Formation of apoptosome	R-HSA-111458	3.445615e-01	0.463
Protein hydroxylation	R-HSA-9629569	4.161491e-01	0.381
MAPK6/MAPK4 signaling	R-HSA-5687128	2.616954e-01	0.582
Cyclin E associated events during G1/S transition	R-HSA-69202	4.488214e-01	0.348
NGF-stimulated transcription	R-HSA-9031628	1.609396e-01	0.793
Ca-dependent events	R-HSA-111996	3.300308e-01	0.481
Other interleukin signaling	R-HSA-449836	3.912451e-01	0.408
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.445615e-01	0.463
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.048962e-01	0.516
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.879132e-01	0.541
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.547324e-01	0.342
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.547324e-01	0.342
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.547324e-01	0.342
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.547324e-01	0.342
Signaling by Interleukins	R-HSA-449147	3.463544e-01	0.460
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.901641e-01	0.537
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.660800e-01	0.436
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.547324e-01	0.342
Cation-coupled Chloride cotransporters	R-HSA-426117	2.415634e-01	0.617
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.415634e-01	0.617
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.760771e-01	0.559
Sodium/Proton exchangers	R-HSA-425986	2.760771e-01	0.559
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.104964e-01	0.508
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.305621e-01	0.366
Cytochrome c-mediated apoptotic response	R-HSA-111461	4.108198e-01	0.386
SARS-CoV-1-host interactions	R-HSA-9692914	2.247851e-01	0.648
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	4.328053e-01	0.364
FLT3 signaling in disease	R-HSA-9682385	2.201344e-01	0.657
Sensory processing of sound	R-HSA-9659379	4.303253e-01	0.366
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.295131e-01	0.639
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	4.427047e-01	0.354
Cleavage of the damaged purine	R-HSA-110331	3.963184e-01	0.402
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.631225e-01	0.787
STING mediated induction of host immune responses	R-HSA-1834941	3.912451e-01	0.408
Depurination	R-HSA-73927	4.146065e-01	0.382
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.735731e-01	0.761
Nef and signal transduction	R-HSA-164944	2.072698e-01	0.683
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.647527e-01	0.577
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.108198e-01	0.386
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.869121e-01	0.542
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.366841e-01	0.473
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	3.509784e-01	0.455
Inositol phosphate metabolism	R-HSA-1483249	3.822471e-01	0.418
Tandem pore domain potassium channels	R-HSA-1296346	3.445615e-01	0.463
Signaling by PDGFR in disease	R-HSA-9671555	2.495247e-01	0.603
Regulation of gene expression in beta cells	R-HSA-210745	2.343880e-01	0.630
FLT3 Signaling	R-HSA-9607240	2.976272e-01	0.526
Regulation of beta-cell development	R-HSA-186712	4.397632e-01	0.357
Cleavage of the damaged pyrimidine	R-HSA-110329	3.300308e-01	0.481
Depyrimidination	R-HSA-73928	3.300308e-01	0.481
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.647527e-01	0.577
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.912424e-01	0.718
OAS antiviral response	R-HSA-8983711	4.427047e-01	0.354
XBP1(S) activates chaperone genes	R-HSA-381038	1.881574e-01	0.725
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.564825e-01	0.591
IRE1alpha activates chaperones	R-HSA-381070	2.450704e-01	0.611
Signaling by Leptin	R-HSA-2586552	3.445615e-01	0.463
Unfolded Protein Response (UPR)	R-HSA-381119	3.009633e-01	0.521
FOXO-mediated transcription	R-HSA-9614085	4.572743e-01	0.340
Trafficking of AMPA receptors	R-HSA-399719	4.573958e-01	0.340
Rab regulation of trafficking	R-HSA-9007101	4.575475e-01	0.340
Regulation of RAS by GAPs	R-HSA-5658442	4.613107e-01	0.336
Cargo trafficking to the periciliary membrane	R-HSA-5620920	4.627086e-01	0.335
Platelet degranulation	R-HSA-114608	4.627239e-01	0.335
Pre-NOTCH Transcription and Translation	R-HSA-1912408	4.631212e-01	0.334
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	4.648657e-01	0.333
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	4.648657e-01	0.333
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.648657e-01	0.333
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	4.687992e-01	0.329
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	4.687992e-01	0.329
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	4.687992e-01	0.329
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	4.687992e-01	0.329
Hh mutants are degraded by ERAD	R-HSA-5362768	4.687992e-01	0.329
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.687992e-01	0.329
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	4.687992e-01	0.329
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	4.694935e-01	0.328
PLC beta mediated events	R-HSA-112043	4.696186e-01	0.328
Signaling by NTRK1 (TRKA)	R-HSA-187037	4.730326e-01	0.325
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	4.736087e-01	0.325
Platelet Adhesion to exposed collagen	R-HSA-75892	4.736087e-01	0.325
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.736087e-01	0.325
CD28 dependent Vav1 pathway	R-HSA-389359	4.736087e-01	0.325
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	4.736087e-01	0.325
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.755729e-01	0.323
trans-Golgi Network Vesicle Budding	R-HSA-199992	4.765238e-01	0.322
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.765238e-01	0.322
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	4.774391e-01	0.321
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.776122e-01	0.321
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.815838e-01	0.317
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.815838e-01	0.317
Defective F9 activation	R-HSA-9673221	4.815838e-01	0.317
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	4.815838e-01	0.317
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	4.815838e-01	0.317
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	4.815838e-01	0.317
Activation of AKT2	R-HSA-165158	4.815838e-01	0.317
Post-transcriptional silencing by small RNAs	R-HSA-426496	4.815838e-01	0.317
PTK6 Down-Regulation	R-HSA-8849472	4.815838e-01	0.317
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	4.815838e-01	0.317
Reelin signalling pathway	R-HSA-8866376	4.815838e-01	0.317
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	4.815838e-01	0.317
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.815838e-01	0.317
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.815838e-01	0.317
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.815838e-01	0.317
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	4.844034e-01	0.315
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.865315e-01	0.313
Degradation of GLI1 by the proteasome	R-HSA-5610780	4.865315e-01	0.313
Degradation of CRY and PER proteins	R-HSA-9932298	4.865315e-01	0.313
FGFR2 alternative splicing	R-HSA-6803529	4.885474e-01	0.311
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.885474e-01	0.311
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	4.885474e-01	0.311
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.885474e-01	0.311
Notch-HLH transcription pathway	R-HSA-350054	4.885474e-01	0.311
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	4.885474e-01	0.311
Ca2+ pathway	R-HSA-4086398	4.902523e-01	0.310
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.934221e-01	0.307
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.934221e-01	0.307
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	4.975307e-01	0.303
Negative regulation of FGFR1 signaling	R-HSA-5654726	4.975307e-01	0.303
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.975307e-01	0.303
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	4.975307e-01	0.303
Assembly of the ORC complex at the origin of replication	R-HSA-68616	4.975307e-01	0.303
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.990691e-01	0.302
Signaling by PTK6	R-HSA-8848021	4.990691e-01	0.302
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	4.990691e-01	0.302
Signal regulatory protein family interactions	R-HSA-391160	5.034514e-01	0.298
Signaling by ERBB4	R-HSA-1236394	5.038798e-01	0.298
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.040494e-01	0.298
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	5.092387e-01	0.293
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.117054e-01	0.291
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.117054e-01	0.291
Carnitine shuttle	R-HSA-200425	5.117054e-01	0.291
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.117054e-01	0.291
Syndecan interactions	R-HSA-3000170	5.117054e-01	0.291
Growth hormone receptor signaling	R-HSA-982772	5.117054e-01	0.291
Vpu mediated degradation of CD4	R-HSA-180534	5.171158e-01	0.286
Cellular responses to mechanical stimuli	R-HSA-9855142	5.183943e-01	0.285
Hh mutants abrogate ligand secretion	R-HSA-5387390	5.213271e-01	0.283
TBC/RABGAPs	R-HSA-8854214	5.213271e-01	0.283
Defective pyroptosis	R-HSA-9710421	5.213271e-01	0.283
Regulation of PD-L1(CD274) expression	R-HSA-9909648	5.245715e-01	0.280
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	5.248690e-01	0.280
Base-Excision Repair, AP Site Formation	R-HSA-73929	5.248690e-01	0.280
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.280367e-01	0.277
IkBA variant leads to EDA-ID	R-HSA-5603029	5.280367e-01	0.277
Defective CSF2RA causes SMDP4	R-HSA-5688890	5.280367e-01	0.277
Defective CSF2RB causes SMDP5	R-HSA-5688849	5.280367e-01	0.277
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	5.280367e-01	0.277
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.280367e-01	0.277
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.280367e-01	0.277
PDE3B signalling	R-HSA-165160	5.280367e-01	0.277
PKB-mediated events	R-HSA-109703	5.280367e-01	0.277
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.280367e-01	0.277
Signalling to p38 via RIT and RIN	R-HSA-187706	5.280367e-01	0.277
Maturation of protein E	R-HSA-9694493	5.280367e-01	0.277
Maturation of protein E	R-HSA-9683683	5.280367e-01	0.277
Erythropoietin activates RAS	R-HSA-9027284	5.321751e-01	0.274
Processive synthesis on the lagging strand	R-HSA-69183	5.321751e-01	0.274
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.321751e-01	0.274
Biotin transport and metabolism	R-HSA-196780	5.321751e-01	0.274
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.321751e-01	0.274
TRAF6 mediated NF-kB activation	R-HSA-933542	5.342954e-01	0.272
CD209 (DC-SIGN) signaling	R-HSA-5621575	5.342954e-01	0.272
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	5.363361e-01	0.271
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.363361e-01	0.271
Gap junction assembly	R-HSA-190861	5.363361e-01	0.271
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	5.363361e-01	0.271
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	5.363361e-01	0.271
Mitophagy	R-HSA-5205647	5.363361e-01	0.271
Signaling by NOTCH2	R-HSA-1980145	5.363361e-01	0.271
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	5.383410e-01	0.269
G alpha (z) signalling events	R-HSA-418597	5.402948e-01	0.267
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	5.440238e-01	0.264
HCMV Infection	R-HSA-9609646	5.539330e-01	0.257
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	5.550699e-01	0.256
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	5.551636e-01	0.256
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	5.551636e-01	0.256
Signalling to ERKs	R-HSA-187687	5.551636e-01	0.256
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.551636e-01	0.256
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.554991e-01	0.255
TNF signaling	R-HSA-75893	5.554991e-01	0.255
G-protein mediated events	R-HSA-112040	5.562217e-01	0.255
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	5.562807e-01	0.255
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.562807e-01	0.255
Long-term potentiation	R-HSA-9620244	5.562807e-01	0.255
Phosphorylation of the APC/C	R-HSA-176412	5.597407e-01	0.252
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.597407e-01	0.252
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	5.597407e-01	0.252
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	5.597407e-01	0.252
Killing mechanisms	R-HSA-9664420	5.597407e-01	0.252
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.597407e-01	0.252
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	5.597407e-01	0.252
Phase 4 - resting membrane potential	R-HSA-5576886	5.597407e-01	0.252
Differentiation of T cells	R-HSA-9945266	5.597407e-01	0.252
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	5.597407e-01	0.252
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.597407e-01	0.252
SARS-CoV-2 Infection	R-HSA-9694516	5.662272e-01	0.247
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	5.700510e-01	0.244
Transcription of the HIV genome	R-HSA-167172	5.700611e-01	0.244
Chylomicron clearance	R-HSA-8964026	5.703297e-01	0.244
Signaling by LTK in cancer	R-HSA-9842640	5.703297e-01	0.244
Erythropoietin activates STAT5	R-HSA-9027283	5.703297e-01	0.244
Autointegration results in viral DNA circles	R-HSA-177539	5.703297e-01	0.244
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	5.703297e-01	0.244
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	5.703297e-01	0.244
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	5.703297e-01	0.244
G2/M DNA replication checkpoint	R-HSA-69478	5.703297e-01	0.244
Neurofascin interactions	R-HSA-447043	5.703297e-01	0.244
Integration of viral DNA into host genomic DNA	R-HSA-175567	5.703297e-01	0.244
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.703297e-01	0.244
Condensation of Prophase Chromosomes	R-HSA-2299718	5.714945e-01	0.243
Regulation of TNFR1 signaling	R-HSA-5357905	5.714945e-01	0.243
Vif-mediated degradation of APOBEC3G	R-HSA-180585	5.735743e-01	0.241
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	5.776312e-01	0.238
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	5.776312e-01	0.238
Cilium Assembly	R-HSA-5617833	5.860790e-01	0.232
G beta:gamma signalling through CDC42	R-HSA-8964616	5.861251e-01	0.232
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	5.861251e-01	0.232
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.861251e-01	0.232
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	5.861251e-01	0.232
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	5.861251e-01	0.232
Coenzyme A biosynthesis	R-HSA-196783	5.861251e-01	0.232
Acetylcholine regulates insulin secretion	R-HSA-399997	5.861251e-01	0.232
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	5.875978e-01	0.231
Ovarian tumor domain proteases	R-HSA-5689896	5.915473e-01	0.228
Degradation of AXIN	R-HSA-4641257	5.915473e-01	0.228
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	5.915473e-01	0.228
Transcriptional regulation by RUNX2	R-HSA-8878166	5.927156e-01	0.227
Transport to the Golgi and subsequent modification	R-HSA-948021	5.947876e-01	0.226
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.983233e-01	0.223
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.983233e-01	0.223
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	5.983233e-01	0.223
Co-stimulation by CD28	R-HSA-389356	6.033648e-01	0.219
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.088351e-01	0.216
TRIF-mediated programmed cell death	R-HSA-2562578	6.088351e-01	0.216
IFNG signaling activates MAPKs	R-HSA-9732724	6.088351e-01	0.216
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	6.088351e-01	0.216
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.088351e-01	0.216
VLDL clearance	R-HSA-8964046	6.088351e-01	0.216
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.088351e-01	0.216
CHL1 interactions	R-HSA-447041	6.088351e-01	0.216
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.088351e-01	0.216
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.090651e-01	0.215
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.090651e-01	0.215
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.103097e-01	0.214
Regulation of mitotic cell cycle	R-HSA-453276	6.103097e-01	0.214
Hedgehog 'on' state	R-HSA-5632684	6.103097e-01	0.214
C-type lectin receptors (CLRs)	R-HSA-5621481	6.106130e-01	0.214
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.113186e-01	0.214
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.113186e-01	0.214
Uptake and function of anthrax toxins	R-HSA-5210891	6.113186e-01	0.214
Telomere Extension By Telomerase	R-HSA-171319	6.183395e-01	0.209
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	6.183395e-01	0.209
Inflammasomes	R-HSA-622312	6.183395e-01	0.209
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	6.183395e-01	0.209
Cytokine Signaling in Immune system	R-HSA-1280215	6.250194e-01	0.204
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	6.261134e-01	0.203
Signaling by ALK	R-HSA-201556	6.261134e-01	0.203
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	6.289354e-01	0.201
Maternal to zygotic transition (MZT)	R-HSA-9816359	6.327995e-01	0.199
MHC class II antigen presentation	R-HSA-2132295	6.327995e-01	0.199
Signaling by ERBB2 ECD mutants	R-HSA-9665348	6.353227e-01	0.197
RNA Polymerase III Transcription Termination	R-HSA-73980	6.353227e-01	0.197
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.353227e-01	0.197
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.353227e-01	0.197
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.353227e-01	0.197
Nephron development	R-HSA-9831926	6.353227e-01	0.197
Selenoamino acid metabolism	R-HSA-2408522	6.366154e-01	0.196
Response of endothelial cells to shear stress	R-HSA-9860931	6.370892e-01	0.196
Late endosomal microautophagy	R-HSA-9615710	6.376670e-01	0.195
mRNA Capping	R-HSA-72086	6.376670e-01	0.195
Platelet calcium homeostasis	R-HSA-418360	6.376670e-01	0.195
PIP3 activates AKT signaling	R-HSA-1257604	6.392433e-01	0.194
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	6.413040e-01	0.193
Interleukin-2 family signaling	R-HSA-451927	6.426805e-01	0.192
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.438918e-01	0.191
MET receptor recycling	R-HSA-8875656	6.438918e-01	0.191
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.438918e-01	0.191
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.438918e-01	0.191
Interleukin-9 signaling	R-HSA-8985947	6.438918e-01	0.191
Adrenoceptors	R-HSA-390696	6.438918e-01	0.191
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.438918e-01	0.191
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.438918e-01	0.191
ROBO receptors bind AKAP5	R-HSA-9010642	6.438918e-01	0.191
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	6.438918e-01	0.191
Downregulation of ERBB4 signaling	R-HSA-1253288	6.438918e-01	0.191
TGFBR3 PTM regulation	R-HSA-9839383	6.438918e-01	0.191
Modulation by Mtb of host immune system	R-HSA-9637628	6.438918e-01	0.191
Activation of NF-kappaB in B cells	R-HSA-1169091	6.485256e-01	0.188
Hedgehog ligand biogenesis	R-HSA-5358346	6.485256e-01	0.188
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.547296e-01	0.184
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.547296e-01	0.184
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	6.552958e-01	0.184
Signaling by ERBB2 in Cancer	R-HSA-1227990	6.562981e-01	0.183
DAP12 signaling	R-HSA-2424491	6.562981e-01	0.183
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	6.579393e-01	0.182
IKK complex recruitment mediated by RIP1	R-HSA-937041	6.581484e-01	0.182
Translesion Synthesis by POLH	R-HSA-110320	6.581484e-01	0.182
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.581484e-01	0.182
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.581484e-01	0.182
SLC transporter disorders	R-HSA-5619102	6.615648e-01	0.179
RNA Polymerase I Promoter Escape	R-HSA-73772	6.628344e-01	0.179
Uptake and actions of bacterial toxins	R-HSA-5339562	6.628344e-01	0.179
Co-inhibition by PD-1	R-HSA-389948	6.649910e-01	0.177
HCMV Late Events	R-HSA-9610379	6.717100e-01	0.173
Regulation of T cell activation by CD28 family	R-HSA-388841	6.737205e-01	0.172
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	6.743385e-01	0.171
MAPK1 (ERK2) activation	R-HSA-112411	6.758086e-01	0.170
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.758086e-01	0.170
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	6.758086e-01	0.170
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.758086e-01	0.170
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	6.758086e-01	0.170
MASTL Facilitates Mitotic Progression	R-HSA-2465910	6.758086e-01	0.170
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.758086e-01	0.170
p75NTR regulates axonogenesis	R-HSA-193697	6.758086e-01	0.170
Regulated proteolysis of p75NTR	R-HSA-193692	6.758086e-01	0.170
Interleukin-1 processing	R-HSA-448706	6.758086e-01	0.170
Respiratory syncytial virus genome replication	R-HSA-9834752	6.758086e-01	0.170
Defects in biotin (Btn) metabolism	R-HSA-3323169	6.758086e-01	0.170
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	6.758086e-01	0.170
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.767593e-01	0.170
Regulation of PTEN stability and activity	R-HSA-8948751	6.767593e-01	0.170
Formation of definitive endoderm	R-HSA-9823730	6.798139e-01	0.168
Cellular response to hypoxia	R-HSA-1234174	6.802640e-01	0.167
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.879015e-01	0.162
Neutrophil degranulation	R-HSA-6798695	6.880541e-01	0.162
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.889110e-01	0.162
Signaling by NTRKs	R-HSA-166520	6.908302e-01	0.161
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	6.914610e-01	0.160
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.930554e-01	0.159
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.930554e-01	0.159
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.930554e-01	0.159
Signaling by Hedgehog	R-HSA-5358351	6.940323e-01	0.159
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.975253e-01	0.156
Lagging Strand Synthesis	R-HSA-69186	7.003438e-01	0.155
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.003438e-01	0.155
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	7.003438e-01	0.155
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.003438e-01	0.155
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.003438e-01	0.155
Zygotic genome activation (ZGA)	R-HSA-9819196	7.003438e-01	0.155
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	7.003438e-01	0.155
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	7.003438e-01	0.155
Signaling by NOTCH3	R-HSA-9012852	7.034401e-01	0.153
Signaling by FGFR4	R-HSA-5654743	7.039974e-01	0.152
Signaling by SCF-KIT	R-HSA-1433557	7.039974e-01	0.152
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.048665e-01	0.152
Binding and entry of HIV virion	R-HSA-173107	7.048665e-01	0.152
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.048665e-01	0.152
Formation of intermediate mesoderm	R-HSA-9761174	7.048665e-01	0.152
EGFR Transactivation by Gastrin	R-HSA-2179392	7.048665e-01	0.152
2-LTR circle formation	R-HSA-164843	7.048665e-01	0.152
Arachidonate production from DAG	R-HSA-426048	7.048665e-01	0.152
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.048665e-01	0.152
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.048665e-01	0.152
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	7.048665e-01	0.152
Defective factor IX causes hemophilia B	R-HSA-9668250	7.048665e-01	0.152
MyD88-independent TLR4 cascade	R-HSA-166166	7.069630e-01	0.151
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	7.069630e-01	0.151
FGFR1 mutant receptor activation	R-HSA-1839124	7.079967e-01	0.150
G-protein beta:gamma signalling	R-HSA-397795	7.079967e-01	0.150
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	7.079967e-01	0.150
Downstream TCR signaling	R-HSA-202424	7.096761e-01	0.149
KEAP1-NFE2L2 pathway	R-HSA-9755511	7.150265e-01	0.146
Signaling by FGFR2	R-HSA-5654738	7.177432e-01	0.144
PKR-mediated signaling	R-HSA-9833482	7.177432e-01	0.144
Proteasome assembly	R-HSA-9907900	7.180736e-01	0.144
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.197676e-01	0.143
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	7.197676e-01	0.143
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.197676e-01	0.143
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	7.197676e-01	0.143
Interleukin-1 family signaling	R-HSA-446652	7.228261e-01	0.141
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.238430e-01	0.140
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.313215e-01	0.136
Signaling by APC mutants	R-HSA-4839744	7.313215e-01	0.136
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	7.313215e-01	0.136
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	7.313215e-01	0.136
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	7.313215e-01	0.136
vRNP Assembly	R-HSA-192905	7.313215e-01	0.136
vRNA Synthesis	R-HSA-192814	7.313215e-01	0.136
Synthesis of PI	R-HSA-1483226	7.313215e-01	0.136
RHOBTB3 ATPase cycle	R-HSA-9706019	7.313215e-01	0.136
Chylomicron assembly	R-HSA-8963888	7.313215e-01	0.136
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.313215e-01	0.136
PECAM1 interactions	R-HSA-210990	7.313215e-01	0.136
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.313215e-01	0.136
Suppression of apoptosis	R-HSA-9635465	7.313215e-01	0.136
Dissolution of Fibrin Clot	R-HSA-75205	7.313215e-01	0.136
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.316494e-01	0.136
Signaling by FGFR3	R-HSA-5654741	7.316494e-01	0.136
PI Metabolism	R-HSA-1483255	7.317721e-01	0.136
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.341398e-01	0.134
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.341398e-01	0.134
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.381187e-01	0.132
Neddylation	R-HSA-8951664	7.389998e-01	0.131
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	7.390092e-01	0.131
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	7.390092e-01	0.131
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	7.405119e-01	0.130
Dual incision in TC-NER	R-HSA-6782135	7.405119e-01	0.130
Extension of Telomeres	R-HSA-180786	7.520837e-01	0.124
PERK regulates gene expression	R-HSA-381042	7.535066e-01	0.123
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.554065e-01	0.122
Proton-coupled monocarboxylate transport	R-HSA-433692	7.554065e-01	0.122
Signaling by GSK3beta mutants	R-HSA-5339716	7.554065e-01	0.122
Integration of provirus	R-HSA-162592	7.554065e-01	0.122
Signaling by AXIN mutants	R-HSA-4839735	7.554065e-01	0.122
Signaling by AMER1 mutants	R-HSA-4839748	7.554065e-01	0.122
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.554065e-01	0.122
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.554065e-01	0.122
Interleukin receptor SHC signaling	R-HSA-912526	7.554332e-01	0.122
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	7.597775e-01	0.119
Interferon Signaling	R-HSA-913531	7.620508e-01	0.118
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	7.637997e-01	0.117
G1/S-Specific Transcription	R-HSA-69205	7.673486e-01	0.115
GPVI-mediated activation cascade	R-HSA-114604	7.673486e-01	0.115
Glycosphingolipid transport	R-HSA-9845576	7.673486e-01	0.115
RET signaling	R-HSA-8853659	7.673486e-01	0.115
Intraflagellar transport	R-HSA-5620924	7.694170e-01	0.114
Gluconeogenesis	R-HSA-70263	7.694170e-01	0.114
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	7.717494e-01	0.113
Complex III assembly	R-HSA-9865881	7.717494e-01	0.113
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.717494e-01	0.113
tRNA processing	R-HSA-72306	7.755544e-01	0.110
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	7.771585e-01	0.109
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	7.773338e-01	0.109
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	7.773338e-01	0.109
Scavenging by Class F Receptors	R-HSA-3000484	7.773338e-01	0.109
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	7.773338e-01	0.109
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	7.773338e-01	0.109
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	7.773338e-01	0.109
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	7.773338e-01	0.109
Interleukin-15 signaling	R-HSA-8983432	7.773338e-01	0.109
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	7.773338e-01	0.109
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	7.773338e-01	0.109
Signaling by LTK	R-HSA-9842663	7.773338e-01	0.109
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.773338e-01	0.109
Diseases associated with surfactant metabolism	R-HSA-5687613	7.773338e-01	0.109
Polymerase switching	R-HSA-69091	7.773338e-01	0.109
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	7.773338e-01	0.109
IRAK1 recruits IKK complex	R-HSA-937039	7.773338e-01	0.109
Leading Strand Synthesis	R-HSA-69109	7.773338e-01	0.109
VLDLR internalisation and degradation	R-HSA-8866427	7.773338e-01	0.109
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	7.773338e-01	0.109
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.773338e-01	0.109
Organelle biogenesis and maintenance	R-HSA-1852241	7.815312e-01	0.107
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.871071e-01	0.104
HDMs demethylate histones	R-HSA-3214842	7.871071e-01	0.104
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	7.871071e-01	0.104
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.892938e-01	0.103
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.908078e-01	0.102
Adenylate cyclase activating pathway	R-HSA-170660	7.972966e-01	0.098
Chylomicron remodeling	R-HSA-8963901	7.972966e-01	0.098
Membrane binding and targetting of GAG proteins	R-HSA-174490	7.972966e-01	0.098
Formation of axial mesoderm	R-HSA-9796292	7.972966e-01	0.098
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	7.972966e-01	0.098
PI5P Regulates TP53 Acetylation	R-HSA-6811555	7.972966e-01	0.098
Interleukin-6 signaling	R-HSA-1059683	7.972966e-01	0.098
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	7.981325e-01	0.098
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	7.981325e-01	0.098
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.006105e-01	0.097
Signaling by EGFR in Cancer	R-HSA-1643713	8.015471e-01	0.096
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	8.041880e-01	0.095
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.047316e-01	0.094
Plasma lipoprotein clearance	R-HSA-8964043	8.050977e-01	0.094
RAS processing	R-HSA-9648002	8.050977e-01	0.094
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.050977e-01	0.094
ER-Phagosome pathway	R-HSA-1236974	8.112975e-01	0.091
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.118709e-01	0.091
Translation	R-HSA-72766	8.130417e-01	0.090
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	8.131265e-01	0.090
RNA Polymerase I Transcription Termination	R-HSA-73863	8.151103e-01	0.089
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.151103e-01	0.089
Cristae formation	R-HSA-8949613	8.151103e-01	0.089
ER Quality Control Compartment (ERQC)	R-HSA-901032	8.151103e-01	0.089
Insulin processing	R-HSA-264876	8.151103e-01	0.089
Removal of the Flap Intermediate	R-HSA-69166	8.154706e-01	0.089
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.154706e-01	0.089
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	8.154706e-01	0.089
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.154706e-01	0.089
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.154706e-01	0.089
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.154706e-01	0.089
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.154706e-01	0.089
cGMP effects	R-HSA-418457	8.154706e-01	0.089
P2Y receptors	R-HSA-417957	8.154706e-01	0.089
Zinc transporters	R-HSA-435354	8.154706e-01	0.089
Nuclear Receptor transcription pathway	R-HSA-383280	8.157964e-01	0.088
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.164794e-01	0.088
Diseases of Immune System	R-HSA-5260271	8.164794e-01	0.088
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.164794e-01	0.088
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.189709e-01	0.087
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.189709e-01	0.087
Extra-nuclear estrogen signaling	R-HSA-9009391	8.231447e-01	0.085
PPARA activates gene expression	R-HSA-1989781	8.232750e-01	0.084
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.278380e-01	0.082
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.320163e-01	0.080
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.320163e-01	0.080
Beta-catenin phosphorylation cascade	R-HSA-196299	8.320163e-01	0.080
RNA Polymerase III Chain Elongation	R-HSA-73780	8.320163e-01	0.080
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.320163e-01	0.080
Translesion synthesis by REV1	R-HSA-110312	8.320163e-01	0.080
Telomere C-strand synthesis initiation	R-HSA-174430	8.320163e-01	0.080
Protein methylation	R-HSA-8876725	8.320163e-01	0.080
DNA Damage Reversal	R-HSA-73942	8.320163e-01	0.080
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.375526e-01	0.077
HIV Transcription Initiation	R-HSA-167161	8.375526e-01	0.077
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.375526e-01	0.077
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.375526e-01	0.077
Signaling by FGFR1 in disease	R-HSA-5655302	8.375526e-01	0.077
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.375526e-01	0.077
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.396007e-01	0.076
Signaling by Erythropoietin	R-HSA-9006335	8.397707e-01	0.076
Signaling by ERBB2 KD Mutants	R-HSA-9664565	8.397707e-01	0.076
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.397707e-01	0.076
Translesion synthesis by POLI	R-HSA-5656121	8.470792e-01	0.072
Defective GALNT3 causes HFTC	R-HSA-5083625	8.470792e-01	0.072
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.470792e-01	0.072
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.470792e-01	0.072
Regulation of BACH1 activity	R-HSA-9708530	8.470792e-01	0.072
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.470792e-01	0.072
Signaling by FGFR1	R-HSA-5654736	8.498042e-01	0.071
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.509488e-01	0.070
Interleukin-37 signaling	R-HSA-9008059	8.509488e-01	0.070
SARS-CoV Infections	R-HSA-9679506	8.527808e-01	0.069
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	8.540434e-01	0.069
RNA Polymerase II Promoter Escape	R-HSA-73776	8.565029e-01	0.067
Gastrulation	R-HSA-9758941	8.571240e-01	0.067
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.607923e-01	0.065
Translesion synthesis by POLK	R-HSA-5655862	8.607923e-01	0.065
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	8.607923e-01	0.065
Synthesis of PG	R-HSA-1483148	8.607923e-01	0.065
tRNA modification in the mitochondrion	R-HSA-6787450	8.607923e-01	0.065
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	8.607923e-01	0.065
Downstream signal transduction	R-HSA-186763	8.614115e-01	0.065
Mitochondrial biogenesis	R-HSA-1592230	8.642384e-01	0.063
DAP12 interactions	R-HSA-2172127	8.652317e-01	0.063
SARS-CoV-1 Infection	R-HSA-9678108	8.689984e-01	0.061
Disorders of transmembrane transporters	R-HSA-5619115	8.707037e-01	0.060
PI3K events in ERBB2 signaling	R-HSA-1963642	8.732764e-01	0.059
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.732764e-01	0.059
Regulation of FZD by ubiquitination	R-HSA-4641263	8.732764e-01	0.059
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.732764e-01	0.059
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.732764e-01	0.059
Regulation of NPAS4 gene expression	R-HSA-9768759	8.732764e-01	0.059
Glycogen storage diseases	R-HSA-3229121	8.732764e-01	0.059
Constitutive Signaling by EGFRvIII	R-HSA-5637810	8.732764e-01	0.059
Signaling by EGFRvIII in Cancer	R-HSA-5637812	8.732764e-01	0.059
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.734893e-01	0.059
Somitogenesis	R-HSA-9824272	8.734893e-01	0.059
Antigen processing-Cross presentation	R-HSA-1236975	8.737528e-01	0.059
Regulation of necroptotic cell death	R-HSA-5675482	8.803434e-01	0.055
Recycling of bile acids and salts	R-HSA-159418	8.803434e-01	0.055
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.803434e-01	0.055
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.812955e-01	0.055
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.812955e-01	0.055
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	8.812955e-01	0.055
Signaling by FGFR in disease	R-HSA-1226099	8.821058e-01	0.054
Hemostasis	R-HSA-109582	8.835414e-01	0.054
Post-translational protein phosphorylation	R-HSA-8957275	8.844072e-01	0.053
Signaling by FGFR	R-HSA-190236	8.844072e-01	0.053
PKA activation in glucagon signalling	R-HSA-164378	8.846417e-01	0.053
PKA activation	R-HSA-163615	8.846417e-01	0.053
Nucleotide-like (purinergic) receptors	R-HSA-418038	8.846417e-01	0.053
Polo-like kinase mediated events	R-HSA-156711	8.846417e-01	0.053
Nuclear events mediated by NFE2L2	R-HSA-9759194	8.850538e-01	0.053
IRS-related events triggered by IGF1R	R-HSA-2428928	8.869039e-01	0.052
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.869039e-01	0.052
MAP kinase activation	R-HSA-450294	8.869039e-01	0.052
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	8.886699e-01	0.051
Synthesis of PC	R-HSA-1483191	8.886699e-01	0.051
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.888857e-01	0.051
Miscellaneous transport and binding events	R-HSA-5223345	8.888857e-01	0.051
Viral Infection Pathways	R-HSA-9824446	8.905799e-01	0.050
NCAM signaling for neurite out-growth	R-HSA-375165	8.932823e-01	0.049
E2F mediated regulation of DNA replication	R-HSA-113510	8.949882e-01	0.048
Diseases of hemostasis	R-HSA-9671793	8.949882e-01	0.048
HDL remodeling	R-HSA-8964058	8.949882e-01	0.048
Metal ion SLC transporters	R-HSA-425410	8.956314e-01	0.048
NOD1/2 Signaling Pathway	R-HSA-168638	8.968590e-01	0.047
Hyaluronan metabolism	R-HSA-2142845	8.968590e-01	0.047
Calnexin/calreticulin cycle	R-HSA-901042	8.968590e-01	0.047
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.978137e-01	0.047
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.021990e-01	0.045
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.042965e-01	0.044
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.044073e-01	0.044
Co-inhibition by CTLA4	R-HSA-389513	9.044073e-01	0.044
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.044073e-01	0.044
Creatine metabolism	R-HSA-71288	9.044073e-01	0.044
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.044073e-01	0.044
Glycogen synthesis	R-HSA-3322077	9.044073e-01	0.044
IGF1R signaling cascade	R-HSA-2428924	9.050975e-01	0.043
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.081142e-01	0.042
PI3K Cascade	R-HSA-109704	9.083911e-01	0.042
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.105589e-01	0.041
Triglyceride catabolism	R-HSA-163560	9.112303e-01	0.040
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.112303e-01	0.040
FGFR2 mutant receptor activation	R-HSA-1839126	9.112303e-01	0.040
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.129821e-01	0.040
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.129821e-01	0.040
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.129821e-01	0.040
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.129821e-01	0.040
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.129821e-01	0.040
Opioid Signalling	R-HSA-111885	9.131453e-01	0.039
The phototransduction cascade	R-HSA-2514856	9.142254e-01	0.039
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.147684e-01	0.039
Potential therapeutics for SARS	R-HSA-9679191	9.153148e-01	0.038
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.176577e-01	0.037
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.207882e-01	0.036
Assembly Of The HIV Virion	R-HSA-175474	9.207882e-01	0.036
Serine metabolism	R-HSA-977347	9.207882e-01	0.036
Glutathione synthesis and recycling	R-HSA-174403	9.207882e-01	0.036
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.207882e-01	0.036
Leishmania phagocytosis	R-HSA-9664417	9.219858e-01	0.035
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.219858e-01	0.035
Parasite infection	R-HSA-9664407	9.219858e-01	0.035
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.237071e-01	0.034
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.237071e-01	0.034
Cytoprotection by HMOX1	R-HSA-9707564	9.278937e-01	0.033
Neurotoxicity of clostridium toxins	R-HSA-168799	9.278944e-01	0.033
RAF-independent MAPK1/3 activation	R-HSA-112409	9.278944e-01	0.033
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.278944e-01	0.033
Ethanol oxidation	R-HSA-71384	9.278944e-01	0.033
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.278944e-01	0.033
LDL clearance	R-HSA-8964038	9.278944e-01	0.033
Pentose phosphate pathway	R-HSA-71336	9.293069e-01	0.032
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.293069e-01	0.032
Stimuli-sensing channels	R-HSA-2672351	9.321730e-01	0.031
Cellular response to chemical stress	R-HSA-9711123	9.335934e-01	0.030
Interleukin-17 signaling	R-HSA-448424	9.338750e-01	0.030
Paracetamol ADME	R-HSA-9753281	9.343265e-01	0.030
Regulation of PTEN mRNA translation	R-HSA-8943723	9.343635e-01	0.029
Termination of O-glycan biosynthesis	R-HSA-977068	9.343635e-01	0.029
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.343635e-01	0.029
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.343635e-01	0.029
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.343635e-01	0.029
Organic anion transport by SLCO transporters	R-HSA-879518	9.343635e-01	0.029
Interleukin-20 family signaling	R-HSA-8854691	9.343635e-01	0.029
Formation of the ureteric bud	R-HSA-9830674	9.343635e-01	0.029
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.345165e-01	0.029
Glycogen metabolism	R-HSA-8982491	9.345165e-01	0.029
Ion homeostasis	R-HSA-5578775	9.386229e-01	0.028
Maturation of spike protein	R-HSA-9694548	9.393607e-01	0.027
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.402526e-01	0.027
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.402526e-01	0.027
TNFs bind their physiological receptors	R-HSA-5669034	9.402526e-01	0.027
Plasma lipoprotein assembly	R-HSA-8963898	9.402526e-01	0.027
Interleukin-6 family signaling	R-HSA-6783589	9.402526e-01	0.027
Dectin-2 family	R-HSA-5621480	9.426580e-01	0.026
IRS-mediated signalling	R-HSA-112399	9.426580e-01	0.026
Intra-Golgi traffic	R-HSA-6811438	9.438632e-01	0.025
Scavenging by Class A Receptors	R-HSA-3000480	9.438632e-01	0.025
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.438632e-01	0.025
FCERI mediated MAPK activation	R-HSA-2871796	9.446565e-01	0.025
Acyl chain remodelling of PS	R-HSA-1482801	9.456136e-01	0.024
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.456136e-01	0.024
Hyaluronan degradation	R-HSA-2160916	9.456136e-01	0.024
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.456136e-01	0.024
Laminin interactions	R-HSA-3000157	9.456136e-01	0.024
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.456136e-01	0.024
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.456136e-01	0.024
ABC-family proteins mediated transport	R-HSA-382556	9.476610e-01	0.023
Cytosolic tRNA aminoacylation	R-HSA-379716	9.480463e-01	0.023
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.480463e-01	0.023
Triglyceride metabolism	R-HSA-8979227	9.499997e-01	0.022
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.499997e-01	0.022
MET activates PTK2 signaling	R-HSA-8874081	9.504938e-01	0.022
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.504938e-01	0.022
TRP channels	R-HSA-3295583	9.504938e-01	0.022
Suppression of phagosomal maturation	R-HSA-9637687	9.504938e-01	0.022
Sphingolipid catabolism	R-HSA-9845614	9.504938e-01	0.022
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.504938e-01	0.022
Response of Mtb to phagocytosis	R-HSA-9637690	9.519311e-01	0.021
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.526338e-01	0.021
tRNA Aminoacylation	R-HSA-379724	9.533326e-01	0.021
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.533326e-01	0.021
Metabolism of polyamines	R-HSA-351202	9.533326e-01	0.021
Neurotransmitter release cycle	R-HSA-112310	9.545187e-01	0.020
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.549364e-01	0.020
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.549364e-01	0.020
Triglyceride biosynthesis	R-HSA-75109	9.549364e-01	0.020
Synthesis of PE	R-HSA-1483213	9.549364e-01	0.020
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.549364e-01	0.020
Maturation of hRSV A proteins	R-HSA-9828806	9.549364e-01	0.020
Surfactant metabolism	R-HSA-5683826	9.555373e-01	0.020
Formation of paraxial mesoderm	R-HSA-9793380	9.564570e-01	0.019
Toll-like Receptor Cascades	R-HSA-168898	9.564668e-01	0.019
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.573631e-01	0.019
Insulin receptor recycling	R-HSA-77387	9.589806e-01	0.018
Pyroptosis	R-HSA-5620971	9.589806e-01	0.018
Mitochondrial protein import	R-HSA-1268020	9.593846e-01	0.018
Signaling by PDGF	R-HSA-186797	9.593846e-01	0.018
Interleukin-10 signaling	R-HSA-6783783	9.599423e-01	0.018
ABC transporter disorders	R-HSA-5619084	9.599423e-01	0.018
Cholesterol biosynthesis	R-HSA-191273	9.599423e-01	0.018
Regulation of pyruvate metabolism	R-HSA-9861718	9.619879e-01	0.017
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.626620e-01	0.017
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.626620e-01	0.017
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	9.626620e-01	0.017
Post-translational protein modification	R-HSA-597592	9.644626e-01	0.016
Insulin receptor signalling cascade	R-HSA-74751	9.646937e-01	0.016
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.660133e-01	0.015
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.660133e-01	0.015
FCERI mediated NF-kB activation	R-HSA-2871837	9.669233e-01	0.015
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.682243e-01	0.014
Adaptive Immune System	R-HSA-1280218	9.686025e-01	0.014
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.690639e-01	0.014
Budding and maturation of HIV virion	R-HSA-162588	9.690639e-01	0.014
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.690639e-01	0.014
Cargo concentration in the ER	R-HSA-5694530	9.690639e-01	0.014
Molecules associated with elastic fibres	R-HSA-2129379	9.690639e-01	0.014
Evasion by RSV of host interferon responses	R-HSA-9833109	9.690639e-01	0.014
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.693438e-01	0.014
Kidney development	R-HSA-9830369	9.714456e-01	0.013
Signaling by WNT in cancer	R-HSA-4791275	9.718409e-01	0.012
Signaling by FGFR2 in disease	R-HSA-5655253	9.722973e-01	0.012
Regulated Necrosis	R-HSA-5218859	9.734103e-01	0.012
Integration of energy metabolism	R-HSA-163685	9.745618e-01	0.011
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.758773e-01	0.011
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.763820e-01	0.010
Glucagon signaling in metabolic regulation	R-HSA-163359	9.766698e-01	0.010
Acyl chain remodelling of PC	R-HSA-1482788	9.766698e-01	0.010
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.766698e-01	0.010
COPII-mediated vesicle transport	R-HSA-204005	9.769615e-01	0.010
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.777257e-01	0.010
Amino acids regulate mTORC1	R-HSA-9639288	9.781994e-01	0.010
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.787644e-01	0.009
NPAS4 regulates expression of target genes	R-HSA-9768919	9.787644e-01	0.009
Acyl chain remodelling of PE	R-HSA-1482839	9.806711e-01	0.008
Neuronal System	R-HSA-112316	9.816930e-01	0.008
Lysosome Vesicle Biogenesis	R-HSA-432720	9.824067e-01	0.008
RSV-host interactions	R-HSA-9833110	9.839474e-01	0.007
Voltage gated Potassium channels	R-HSA-1296072	9.839865e-01	0.007
NCAM1 interactions	R-HSA-419037	9.839865e-01	0.007
Metabolism of folate and pterines	R-HSA-196757	9.839865e-01	0.007
Collagen chain trimerization	R-HSA-8948216	9.839865e-01	0.007
Interferon gamma signaling	R-HSA-877300	9.847052e-01	0.007
Elastic fibre formation	R-HSA-1566948	9.854245e-01	0.006
Signaling by Insulin receptor	R-HSA-74752	9.860931e-01	0.006
Translation of Structural Proteins	R-HSA-9694635	9.861563e-01	0.006
Amino acid transport across the plasma membrane	R-HSA-352230	9.865703e-01	0.006
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.870105e-01	0.006
Integrin cell surface interactions	R-HSA-216083	9.871395e-01	0.006
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.878700e-01	0.005
Tryptophan catabolism	R-HSA-71240	9.879250e-01	0.005
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.880553e-01	0.005
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.890096e-01	0.005
Aflatoxin activation and detoxification	R-HSA-5423646	9.890096e-01	0.005
Formation of the cornified envelope	R-HSA-6809371	9.891486e-01	0.005
Translation of Structural Proteins	R-HSA-9683701	9.899968e-01	0.004
Activation of GABAB receptors	R-HSA-991365	9.908954e-01	0.004
GABA B receptor activation	R-HSA-977444	9.908954e-01	0.004
Regulation of insulin secretion	R-HSA-422356	9.914142e-01	0.004
Parasitic Infection Pathways	R-HSA-9824443	9.914295e-01	0.004
Leishmania infection	R-HSA-9658195	9.914295e-01	0.004
Transmission across Chemical Synapses	R-HSA-112315	9.919222e-01	0.004
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.924577e-01	0.003
Amine ligand-binding receptors	R-HSA-375280	9.924577e-01	0.003
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.929819e-01	0.003
SLC-mediated transport of amino acids	R-HSA-9958863	9.930272e-01	0.003
Role of phospholipids in phagocytosis	R-HSA-2029485	9.930954e-01	0.003
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.931354e-01	0.003
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.931354e-01	0.003
Pyruvate metabolism	R-HSA-70268	9.939111e-01	0.003
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.945600e-01	0.002
GPER1 signaling	R-HSA-9634597	9.948246e-01	0.002
Plasma lipoprotein remodeling	R-HSA-8963899	9.948246e-01	0.002
ECM proteoglycans	R-HSA-3000178	9.949934e-01	0.002
Chemokine receptors bind chemokines	R-HSA-380108	9.952897e-01	0.002
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.953928e-01	0.002
Azathioprine ADME	R-HSA-9748787	9.957130e-01	0.002
Aspirin ADME	R-HSA-9749641	9.957609e-01	0.002
Complex IV assembly	R-HSA-9864848	9.960983e-01	0.002
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.961458e-01	0.002
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.961458e-01	0.002
Protein localization	R-HSA-9609507	9.962463e-01	0.002
Iron uptake and transport	R-HSA-917937	9.964126e-01	0.002
Bile acid and bile salt metabolism	R-HSA-194068	9.965836e-01	0.001
Collagen formation	R-HSA-1474290	9.966950e-01	0.001
Mitochondrial protein degradation	R-HSA-9837999	9.966950e-01	0.001
Nucleotide biosynthesis	R-HSA-8956320	9.967682e-01	0.001
Extracellular matrix organization	R-HSA-1474244	9.969150e-01	0.001
SLC-mediated transport of organic anions	R-HSA-9955298	9.972097e-01	0.001
Potassium Channels	R-HSA-1296071	9.973787e-01	0.001
Digestion	R-HSA-8935690	9.975638e-01	0.001
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.975638e-01	0.001
Phospholipid metabolism	R-HSA-1483257	9.977225e-01	0.001
Synthesis of PA	R-HSA-1483166	9.977828e-01	0.001
Synthesis of bile acids and bile salts	R-HSA-192105	9.979237e-01	0.001
Cardiac conduction	R-HSA-5576891	9.979669e-01	0.001
Peroxisomal protein import	R-HSA-9033241	9.981636e-01	0.001
GABA receptor activation	R-HSA-977443	9.983288e-01	0.001
Signaling by Retinoic Acid	R-HSA-5362517	9.983288e-01	0.001
Glutathione conjugation	R-HSA-156590	9.983288e-01	0.001
Endogenous sterols	R-HSA-211976	9.984790e-01	0.001
Aquaporin-mediated transport	R-HSA-445717	9.984790e-01	0.001
Collagen degradation	R-HSA-1442490	9.984790e-01	0.001
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.987022e-01	0.001
Complex I biogenesis	R-HSA-6799198	9.987403e-01	0.001
Digestion and absorption	R-HSA-8963743	9.987403e-01	0.001
G alpha (q) signalling events	R-HSA-416476	9.988467e-01	0.001
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.988613e-01	0.000
Platelet homeostasis	R-HSA-418346	9.988915e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.989055e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.991360e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.991552e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.992137e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.992137e-01	0.000
FCGR activation	R-HSA-2029481	9.993399e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.994075e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.994075e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.995015e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.995093e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.995315e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.995535e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.996352e-01	0.000
Ion channel transport	R-HSA-983712	9.996617e-01	0.000
Metabolism of proteins	R-HSA-392499	9.997063e-01	0.000
Immune System	R-HSA-168256	9.997225e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.997693e-01	0.000
Visual phototransduction	R-HSA-2187338	9.998648e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.998703e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.998801e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.998875e-01	0.000
Interferon alpha/beta signaling	R-HSA-909733	9.999304e-01	0.000
Infectious disease	R-HSA-5663205	9.999390e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999416e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999578e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999588e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999651e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999655e-01	0.000
Keratinization	R-HSA-6805567	9.999740e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999782e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999811e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999812e-01	0.000
Innate Immune System	R-HSA-168249	9.999821e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999839e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999839e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999888e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999957e-01	0.000
Disease	R-HSA-1643685	9.999962e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999972e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999983e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999984e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999990e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999995e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999995e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999996e-01	0.000
Drug ADME	R-HSA-9748784	9.999996e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999997e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999998e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999999e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000