PAK6

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O14579 S99 Sugiyama COPE PELQAVRMFADyLAHEsRRDsIVAELDREMsRSVDVTNTTF
O14713 S10 PSP ITGB1BP1 ICAP1 ___________MFRKGKKRHssSsSQSSEISTKSKsVDssL
O15013 S1232 Sugiyama ARHGEF10 KIAA0294 VKFIVLATALHEKDKDKsRDsLAPGPEPQDEDQKDALPSGG
O43159 S309 Sugiyama RRP8 KIAA0409 NML hucep-1 KKWPLQPVDRIARDLRQRPAsLVVADFGCGDCRLASSIRNP
O60343 S757 Sugiyama TBC1D4 AS160 KIAA0603 ASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRISWRQRIF
O60343 T749 Sugiyama TBC1D4 AS160 KIAA0603 ENEIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRR
O75534 S584 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR YSLSKGKGNKVSAEKVNKtHsVNGItEEADPTIysGKVIRP
O95613 S1814 Sugiyama PCNT KIAA0402 PCNT2 AALEAKEALSRLLADQERRHsQALEALQQRLQGAEEAAELQ
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95816 S157 Sugiyama BAG2 SLYSACSSEVPHGPVDQKFQsIVIGCALEDQKKIKRRLETL
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04049 S338 EPSD RAF1 RAF RAPVsGtQEKNKIRPRGQRDssyyWEIEASEVMLSTRIGsG
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787 S330 Sugiyama KRT8 CYK8 MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08670 S325 Sugiyama VIM NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09972 S45 Sugiyama ALDOC ALDC APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P10275 S579 EPSD|PSP AR DHTR NR3C4 TCLICGDEASGCHYGALTCGsCKVFFKRAAEGKQKYLCASR
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13807 S710 Sugiyama GYS1 GYS APEWPRRAsCTsSTSGSKRNsVDtAtsssLstPsEPLsPts
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P15923 S39 EPSD TCF3 BHLHB21 E2A ITF1 LLDFSMMFPLPVTNGKGRPAsLAGAQFGGsGLEDRPssGSW
P15976 S161 EPSD GATA1 ERYF1 GF1 LSPDLLTLGPALPSSLPVPNsAYGGPDFSsTFFsPtGsPLN
P15976 S187 EPSD GATA1 ERYF1 GF1 DFSsTFFsPtGsPLNSAAYSsPKLRGTLPLPPCEARECVNC
P16083 S80 Sugiyama NQO2 NMOR2 LSNPEVFNyGVEtHEAyKQRsLAsDITDEQKKVREADLVIF
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17987 S374 Sugiyama TCP1 CCT1 CCTA ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P25205 S447 Sugiyama MCM3 EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27448 S42 Sugiyama MARK3 CTAK1 EMK2 GDGRQEVTSRTSRSGARCRNsIAsCADEQPHIGNyRLLKTI
P29692 S60 Sugiyama EEF1D EF1D ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P30048 S199 Sugiyama PRDX3 AOP1 SGLALRGLFIIDPNGVIKHLsVNDLPVGRSVEETLRLVKAF
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P45974 S783 Sugiyama USP5 ISOT IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL
P46013 S648 Sugiyama MKI67 RVSISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLG
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47712 S729 Sugiyama PLA2G4A CPLA2 PLA2G4 KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49588 S775 Sugiyama AARS1 AARS VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P49736 S229 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 sHGHNVFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLP
P49792 S786 Sugiyama RANBP2 NUP358 GsLRNADsEIKHstPsPtRYsLsPsKsyKYsPKtPPRWAED
P50395 S427 Sugiyama GDI2 RABGDIB ttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED__
P50395 T425 Sugiyama GDI2 RABGDIB DAttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396 S656 Sugiyama ACLY IGNTGGMLDNILASKLyRPGsVAyVSRsGGMsNELNNIISR
P53667 T508 EPSD|PSP LIMK1 LIMK EKTQPEGLRSLKKPDRKKRYtVVGNPyWMAPEMINGRSYDE
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54750 S345 Sugiyama PDE1A EMVLSTDMSGHFQQIKNIRNsLQQPEGIDRAKTMSLILHAA
P56545 S164 PSP CTBP2 NLYRRNTWLYQALREGTRVQsVEQIREVASGAARIRGETLG
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63146 S142 Sugiyama UBE2B RAD6B UBCH1 ANSQAAQLYQENKREYEKRVsAIVEQsWNDS__________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
Q00610 S147 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 VYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLLL
Q00613 S375 Sugiyama HSF1 HSTF1 TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q00987 S186 SIGNOR|EPSD|PSP MDM2 sEtEENsDELsGERQRKRHKsDsISLsFDESLALCVIREIC
Q00987 T158 SIGNOR|EPSD|PSP MDM2 LVQELQEEKPSSSHLVSRPstSSRRRAIsEtEENsDELsGE
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q04917 S145 Sugiyama YWHAH YWHA1 KMKGDYYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQM
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q08378 S497 Sugiyama GOLGA3 CWDLERAMTDLQNMLEAKNAsLAssNNDLQVAEEQyQRLMA
Q12906 S20 Sugiyama ILF3 DRBF MPHOSPH4 NF90 _MRPMRIFVNDDRHVMAKHssVyPTQEELEAVQNMVsHtER
Q13126 S123 Sugiyama MTAP MSAP QPGDIVIIDQFIDRTTMRPQsFyDGSHSCARGVCHIPMAEP
Q13363 S100 PSP CTBP1 CTBP TLTREDLEKFKALRIIVRIGsGFDNIDIKSAGDLGIAVCNV
Q13363 S158 PSP CTBP1 CTBP NLYRRAtWLHQALREGTRVQsVEQIREVASGAARIRGETLG
Q13501 S24 Sugiyama SQSTM1 ORCA OSIL LTVKAYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPC
Q13625 S736 Sugiyama TP53BP2 ASPP2 BBP ADLEALRKKLSNAPRPLKKRssItEPEGPNGPNIQKLLYQR
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6IBS0 S139 Sugiyama TWF2 PTK9L MSTP011 DELFGTVKDDLSFAGyQKHLssCAAPAPLtsAERELQQIRI
Q6P1J9 S212 Sugiyama CDC73 C1orf28 HRPT2 KKRSTIKTDLDDDITALKQRsFVDAEVDVTRDIVSRERVWR
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q7KZF4 S150 Sugiyama SND1 TDRD11 EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS
Q7L5Y9 S226 Sugiyama MAEA EMP HLC10 PIG5 IELIRQNKRLDAVRHARKHFsQAEGSQLDEVRQAMGMLAFP
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8N584 S472 Sugiyama TTC39C C18orf17 EVLYLWKALPNCSFPNLQRMsQACHEVDDSSVVGLKYLLLG
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8TCS8 S767 Sugiyama PNPT1 PNPASE LSRKVLQsPAtTVVRTLNDRssIVMGEPIsQSSSNsQ____
Q8TCS8 S768 Sugiyama PNPT1 PNPASE SRKVLQsPAtTVVRTLNDRssIVMGEPIsQSSSNsQ_____
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8TEQ6 S644 Sugiyama GEMIN5 sPVTITEPYRTLSGHTAKITsVAWsPHHDGRLVSASYDGTA
Q92934 S75 EPSD BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q969S3 S38 Sugiyama ZNF622 ZPR9 MQRAHYKTDWHRYNLRRKVAsMAPVTAEGFQERVRAQRAVA
Q96D15 S117 Sugiyama RCN3 UNQ239/PRO272 VsLAELRAWIAHTQQRHIRDsVsAAWDtyDtDRDGRVGWEE
Q96N67 S180 Sugiyama DOCK7 KIAA1771 SDEAPDGNSyQDDQDDLKRRsMsIDDTPRGsWACSIFDLKN
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q9BY11 S346 SIGNOR|EPSD|PSP PACSIN1 KIAA1379 VALTNAtGAVEstsQAGDRGsVssyDRGQPYATEWsDDESG
Q9C0C2 S872 Sugiyama TNKS1BP1 KIAA1741 TAB182 QGtyssRDAELQDQEFGKRDsLGtyssRDVsLGDWEFGKRD
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9HCN4 S301 Sugiyama GPN1 MBDIN RPAP4 XAB1 HUSSY-23 ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD
Q9NQU5 S113 Sugiyama PAK6 PAK5 SVISSNtLRGRSPTSRRRAQsLGLLGDEHWATDPDMYLQsP
Q9NQU5 S132 Sugiyama PAK6 PAK5 QsLGLLGDEHWATDPDMYLQsPQSERTDPHGLyLsCNGGtP
Q9NQU5 S146 Sugiyama PAK6 PAK5 PDMYLQsPQSERTDPHGLyLsCNGGtPAGHKQMPWPEPQsP
Q9NQU5 S165 Sugiyama PAK6 PAK5 LsCNGGtPAGHKQMPWPEPQsPRVLPNGLAAKAQsLGPAEF
Q9NQU5 S179 Sugiyama PAK6 PAK5 PWPEPQsPRVLPNGLAAKAQsLGPAEFQGAsQRCLQLGACL
Q9NQU5 S189 Sugiyama PAK6 PAK5 LPNGLAAKAQsLGPAEFQGAsQRCLQLGACLQSsPPGAsPP
Q9NQU5 S202 Sugiyama PAK6 PAK5 PAEFQGAsQRCLQLGACLQSsPPGAsPPtGTNRHGMKAAKH
Q9NQU5 S224 Sugiyama PAK6 PAK5 PGAsPPtGTNRHGMKAAKHGsEEARPQsCLVGsAtGRPGGE
Q9NQU5 S231 Sugiyama PAK6 PAK5 GTNRHGMKAAKHGsEEARPQsCLVGsAtGRPGGEGsPsPKT
Q9NQU5 S246 Sugiyama PAK6 PAK5 EARPQsCLVGsAtGRPGGEGsPsPKTRESSLKRRLFRSMFL
Q9NQU5 S248 Sugiyama PAK6 PAK5 RPQsCLVGsAtGRPGGEGsPsPKTRESSLKRRLFRSMFLST
Q9NQU5 S301 Sugiyama PAK6 PAK5 PPPQSKPNSSFRPPQKDNPPsLVAKAQsLPSDQPVGTFSPL
Q9NQU5 S332 Sugiyama PAK6 PAK5 DQPVGTFSPLTtsDtssPQKsLRTAPAtGQLPGRssPAGsP
Q9NQU5 S346 Sugiyama PAK6 PAK5 tssPQKsLRTAPAtGQLPGRssPAGsPRtWHAQIsTSNLyL
Q9NQU5 S347 Sugiyama PAK6 PAK5 ssPQKsLRTAPAtGQLPGRssPAGsPRtWHAQIsTSNLyLP
Q9NQU5 S351 Sugiyama PAK6 PAK5 KsLRTAPAtGQLPGRssPAGsPRtWHAQIsTSNLyLPQDPT
Q9NQU5 T151 Sugiyama PAK6 PAK5 QsPQSERTDPHGLyLsCNGGtPAGHKQMPWPEPQsPRVLPN
Q9NQU5 T210 Sugiyama PAK6 PAK5 QRCLQLGACLQSsPPGAsPPtGTNRHGMKAAKHGsEEARPQ
Q9NQU5 T238 Sugiyama PAK6 PAK5 KAAKHGsEEARPQsCLVGsAtGRPGGEGsPsPKTRESSLKR
Q9NQU5 T339 Sugiyama PAK6 PAK5 SPLTtsDtssPQKsLRTAPAtGQLPGRssPAGsPRtWHAQI
Q9NQU5 T382 Sugiyama PAK6 PAK5 SNLyLPQDPTVAKGALAGEDtGVVTHEQFKAALRMVVDQGD
Q9NQX3 S280 Sugiyama GPHN GPH KIAA1385 TAsLsttPsEsPRAQAtsRLstAsCPtPKVQSRCSsKENIL
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9P286 S573 EPSD PAK5 KIAA1264 PAK7 LRALSYLHNQGVIHRDIKSDsILLTSDGRIKLSDFGFCAQV
Q9UBU9 S431 Sugiyama NXF1 TAP HDGACCSLSIPFIPQNPARSsLAEyFKDSRNVKKLKDPTLR
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UIQ6 S670 Sugiyama LNPEP OTASE YLWHIPLSYVTEGRNYSKYQsVSLLDKKSGVINLTEEVLWV
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 4.002021e-12 11.398 0 0
HSF1-dependent transactivation R-HSA-3371571 1.737388e-09 8.760 0 0
Cell Cycle, Mitotic R-HSA-69278 2.761110e-09 8.559 0 0
Cell Cycle Checkpoints R-HSA-69620 4.987966e-09 8.302 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.408804e-08 7.851 0 0
Cellular response to heat stress R-HSA-3371556 1.629107e-08 7.788 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.825560e-08 7.739 0 0
HDACs deacetylate histones R-HSA-3214815 2.654355e-08 7.576 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.363648e-08 7.473 0 0
Meiotic synapsis R-HSA-1221632 5.287301e-08 7.277 0 0
DNA methylation R-HSA-5334118 9.069751e-08 7.042 0 0
Diseases of programmed cell death R-HSA-9645723 1.714749e-07 6.766 0 0
M Phase R-HSA-68886 1.764265e-07 6.753 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.081391e-07 6.682 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.251709e-07 6.647 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.675295e-07 6.330 0 0
Attenuation phase R-HSA-3371568 4.627642e-07 6.335 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.627642e-07 6.335 0 0
Meiosis R-HSA-1500620 6.077201e-07 6.216 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 6.443299e-07 6.191 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.827979e-07 6.166 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.163766e-07 6.145 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.543406e-07 6.068 0 0
Chromatin modifying enzymes R-HSA-3247509 9.326745e-07 6.030 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 9.788586e-07 6.009 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.321659e-06 5.879 0 0
Signal Transduction R-HSA-162582 1.362939e-06 5.866 1 0
HSF1 activation R-HSA-3371511 1.868651e-06 5.728 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.904138e-06 5.720 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.989978e-06 5.701 0 0
Chromatin organization R-HSA-4839726 2.702925e-06 5.568 0 0
Packaging Of Telomere Ends R-HSA-171306 3.779553e-06 5.423 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.927059e-06 5.406 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.757371e-06 5.425 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.242249e-06 5.372 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.676190e-06 5.246 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.510149e-06 5.186 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.752482e-06 5.171 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.697409e-06 5.061 0 0
Nucleosome assembly R-HSA-774815 1.011583e-05 4.995 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.011583e-05 4.995 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.625838e-06 5.017 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.082127e-05 4.966 0 0
Reproduction R-HSA-1474165 1.141613e-05 4.942 0 0
Meiotic recombination R-HSA-912446 1.449139e-05 4.839 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.667114e-05 4.778 0 0
Death Receptor Signaling R-HSA-73887 1.789533e-05 4.747 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.938159e-05 4.713 0 0
Defective pyroptosis R-HSA-9710421 1.976901e-05 4.704 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.089710e-05 4.680 0 0
Mitotic Prophase R-HSA-68875 2.307702e-05 4.637 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.700911e-05 4.568 0 0
G2/M Checkpoints R-HSA-69481 3.256133e-05 4.487 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.554317e-05 4.449 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.970226e-05 4.304 0 0
Depyrimidination R-HSA-73928 4.970226e-05 4.304 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 5.583922e-05 4.253 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.520791e-05 4.258 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.723974e-05 4.242 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.623450e-05 4.179 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.592264e-05 4.120 0 0
Nervous system development R-HSA-9675108 1.036632e-04 3.984 1 0
Processing of DNA double-strand break ends R-HSA-5693607 1.079314e-04 3.967 0 0
Cleavage of the damaged purine R-HSA-110331 1.133623e-04 3.946 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.202017e-04 3.920 0 0
Apoptotic execution phase R-HSA-75153 1.281015e-04 3.892 0 0
NRAGE signals death through JNK R-HSA-193648 1.306787e-04 3.884 0 0
Depurination R-HSA-73927 1.456592e-04 3.837 0 0
Regulation of TP53 Activity R-HSA-5633007 1.570765e-04 3.804 0 0
RNA Polymerase I Transcription R-HSA-73864 1.610163e-04 3.793 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.610163e-04 3.793 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.764809e-04 3.753 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.908368e-04 3.719 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.908368e-04 3.719 0 0
Axon guidance R-HSA-422475 2.109601e-04 3.676 1 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.163604e-04 3.665 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.348796e-04 3.629 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.430664e-04 3.614 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.430664e-04 3.614 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.736834e-04 3.563 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.832252e-04 3.548 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.079236e-04 3.512 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.291993e-04 3.483 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.291993e-04 3.483 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.394415e-04 3.469 0 0
Mitotic Prometaphase R-HSA-68877 4.060468e-04 3.391 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.215184e-04 3.375 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.912444e-04 3.309 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.912444e-04 3.309 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.087638e-04 3.216 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 6.424414e-04 3.192 0 0
RMTs methylate histone arginines R-HSA-3214858 6.883624e-04 3.162 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.883624e-04 3.162 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.142061e-04 3.146 0 0
Cellular Senescence R-HSA-2559583 7.179058e-04 3.144 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.587712e-04 3.120 0 0
Signaling by WNT R-HSA-195721 7.764378e-04 3.110 0 0
Gene expression (Transcription) R-HSA-74160 7.934079e-04 3.101 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 8.154366e-04 3.089 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.550695e-04 3.068 0 0
G alpha (12/13) signalling events R-HSA-416482 9.082261e-04 3.042 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.192967e-04 3.037 0 0
DNA Double Strand Break Response R-HSA-5693606 9.323284e-04 3.030 0 0
Formation of definitive endoderm R-HSA-9823730 1.027610e-03 2.988 0 0
Signaling by ROBO receptors R-HSA-376176 1.002925e-03 2.999 1 0
Epigenetic regulation of gene expression R-HSA-212165 1.077734e-03 2.967 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.159085e-03 2.936 0 0
Neurodegenerative Diseases R-HSA-8863678 1.178888e-03 2.929 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.178888e-03 2.929 0 0
Programmed Cell Death R-HSA-5357801 1.292749e-03 2.888 0 0
RNA Polymerase II Transcription R-HSA-73857 1.412985e-03 2.850 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.471505e-03 2.832 0 0
Gene Silencing by RNA R-HSA-211000 1.476356e-03 2.831 0 0
Interleukin-37 signaling R-HSA-9008059 1.598197e-03 2.796 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.641477e-03 2.785 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.670905e-03 2.777 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.799306e-03 2.745 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.799306e-03 2.745 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.875079e-03 2.727 0 0
Cell junction organization R-HSA-446728 2.062303e-03 2.686 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.080610e-03 2.682 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.255953e-03 2.647 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.255953e-03 2.647 0 0
Ub-specific processing proteases R-HSA-5689880 2.168734e-03 2.664 0 0
Apoptosis R-HSA-109581 2.357741e-03 2.628 0 0
Activation of RAC1 R-HSA-428540 2.444775e-03 2.612 1 1
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.451789e-03 2.611 0 0
mRNA 3'-end processing R-HSA-72187 2.862825e-03 2.543 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.940810e-03 2.532 0 0
Centrosome maturation R-HSA-380287 2.954606e-03 2.530 0 0
Homology Directed Repair R-HSA-5693538 3.110063e-03 2.507 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.622752e-03 2.441 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.639997e-03 2.439 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.680358e-03 2.434 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.680358e-03 2.434 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.680358e-03 2.434 0 0
Generic Transcription Pathway R-HSA-212436 4.015365e-03 2.396 0 0
Cell-Cell communication R-HSA-1500931 4.020141e-03 2.396 0 0
Chromosome Maintenance R-HSA-73886 4.189960e-03 2.378 0 0
HATs acetylate histones R-HSA-3214847 4.199933e-03 2.377 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.600273e-03 2.337 0 0
HDMs demethylate histones R-HSA-3214842 4.719630e-03 2.326 0 0
RAF activation R-HSA-5673000 4.483903e-03 2.348 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.701462e-03 2.328 0 0
Deubiquitination R-HSA-5688426 4.382138e-03 2.358 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.884589e-03 2.311 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.809957e-03 2.236 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.828695e-03 2.234 0 0
G2/M Transition R-HSA-69275 6.137712e-03 2.212 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.141980e-03 2.212 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 6.155661e-03 2.211 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.160541e-03 2.210 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.160541e-03 2.210 0 0
Amyloid fiber formation R-HSA-977225 6.213560e-03 2.207 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 7.478124e-03 2.126 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 7.478124e-03 2.126 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.626382e-03 2.118 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.105561e-03 2.148 0 0
Notch-HLH transcription pathway R-HSA-350054 7.295734e-03 2.137 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 7.966907e-03 2.099 0 0
Mitotic Anaphase R-HSA-68882 8.006489e-03 2.097 0 0
ESR-mediated signaling R-HSA-8939211 8.158050e-03 2.088 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.212221e-03 2.086 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.212221e-03 2.086 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.553687e-03 2.068 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 8.709620e-03 2.060 0 0
Adherens junctions interactions R-HSA-418990 9.131718e-03 2.039 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 9.454712e-03 2.024 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.039702e-02 1.983 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.106864e-02 1.956 0 0
Ion homeostasis R-HSA-5578775 1.151768e-02 1.939 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.228806e-02 1.911 0 0
Telomere Maintenance R-HSA-157579 1.231341e-02 1.910 0 0
TGFBR3 expression R-HSA-9839394 1.340955e-02 1.873 0 0
Repression of WNT target genes R-HSA-4641265 1.331816e-02 1.876 0 0
Long-term potentiation R-HSA-9620244 1.340955e-02 1.873 0 0
FLT3 Signaling R-HSA-9607240 1.424773e-02 1.846 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.463146e-02 1.835 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.463146e-02 1.835 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.463146e-02 1.835 0 0
Signaling by RAS mutants R-HSA-6802949 1.463146e-02 1.835 0 0
Neurexins and neuroligins R-HSA-6794361 1.478993e-02 1.830 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.563789e-02 1.806 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.617744e-02 1.791 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.632765e-02 1.787 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.643632e-02 1.784 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.713941e-02 1.766 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.713941e-02 1.766 0 0
Formation of axial mesoderm R-HSA-9796292 1.737864e-02 1.760 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.737864e-02 1.760 0 0
Specification of primordial germ cells R-HSA-9827857 1.770819e-02 1.752 0 0
Base Excision Repair R-HSA-73884 1.771612e-02 1.752 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.803416e-02 1.744 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.073176e-02 1.683 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.919523e-02 1.717 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.050267e-02 1.688 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.844108e-02 1.734 0 0
Cell-cell junction organization R-HSA-421270 1.863211e-02 1.730 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.944729e-02 1.711 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.050267e-02 1.688 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.085565e-02 1.681 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.156459e-02 1.666 0 0
Regulation of KIT signaling R-HSA-1433559 2.221680e-02 1.653 0 0
Cellular responses to stress R-HSA-2262752 2.334800e-02 1.632 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.383408e-02 1.623 0 0
TNF signaling R-HSA-75893 2.394027e-02 1.621 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.418416e-02 1.616 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.421350e-02 1.616 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.421350e-02 1.616 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.421350e-02 1.616 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.421350e-02 1.616 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.421350e-02 1.616 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.432420e-02 1.614 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.439603e-02 1.613 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.788824e-02 1.555 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.788824e-02 1.555 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.660250e-02 1.575 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.672091e-02 1.573 0 0
Netrin-1 signaling R-HSA-373752 2.452784e-02 1.610 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.677427e-02 1.572 0 0
DNA Replication R-HSA-69306 2.598524e-02 1.585 0 0
Co-inhibition by PD-1 R-HSA-389948 2.441416e-02 1.612 0 0
Specification of the neural plate border R-HSA-9834899 2.670975e-02 1.573 0 0
Semaphorin interactions R-HSA-373755 2.601393e-02 1.585 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.656934e-02 1.576 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.482774e-02 1.605 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.066925e-02 1.513 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.069344e-02 1.513 0 0
Activation of BH3-only proteins R-HSA-114452 3.097650e-02 1.509 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.289942e-02 1.483 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.289942e-02 1.483 0 0
Cardiac conduction R-HSA-5576891 3.323001e-02 1.478 0 0
Separation of Sister Chromatids R-HSA-2467813 3.351175e-02 1.475 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.444007e-02 1.463 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.457612e-02 1.461 0 0
Trafficking of AMPA receptors R-HSA-399719 3.582720e-02 1.446 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.587162e-02 1.445 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 3.587162e-02 1.445 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.587162e-02 1.445 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.587162e-02 1.445 0 0
RET signaling R-HSA-8853659 3.614498e-02 1.442 0 0
Kinesins R-HSA-983189 3.675754e-02 1.435 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.675754e-02 1.435 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.675754e-02 1.435 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.675754e-02 1.435 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.675754e-02 1.435 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.675754e-02 1.435 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.838703e-02 1.416 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.887047e-02 1.410 0 0
Type I hemidesmosome assembly R-HSA-446107 4.399177e-02 1.357 0 0
FOXO-mediated transcription R-HSA-9614085 4.473564e-02 1.349 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.042820e-02 1.393 0 0
Protein ubiquitination R-HSA-8852135 4.429383e-02 1.354 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.438221e-02 1.353 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.399177e-02 1.357 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.399177e-02 1.357 0 0
Signaling by NOTCH R-HSA-157118 4.644619e-02 1.333 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.645834e-02 1.333 0 0
Signaling by EGFR R-HSA-177929 4.683157e-02 1.329 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.683157e-02 1.329 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.703519e-02 1.328 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.703519e-02 1.328 0 0
Nuclear RNA decay R-HSA-9930044 4.703519e-02 1.328 0 0
Signaling by NOTCH1 R-HSA-1980143 4.828284e-02 1.316 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.916295e-02 1.308 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 5.042834e-02 1.297 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 5.042834e-02 1.297 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 5.042834e-02 1.297 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 5.042834e-02 1.297 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.042834e-02 1.297 0 0
Cellular responses to stimuli R-HSA-8953897 5.183634e-02 1.285 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.251806e-02 1.280 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.371783e-02 1.270 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.382415e-02 1.269 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.692967e-02 1.245 0 0
Calcineurin activates NFAT R-HSA-2025928 5.692967e-02 1.245 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.692967e-02 1.245 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.970578e-02 1.224 0 0
Ephrin signaling R-HSA-3928664 5.970578e-02 1.224 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.035443e-02 1.219 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.035443e-02 1.219 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.035443e-02 1.219 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.051800e-02 1.218 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.051800e-02 1.218 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.147212e-02 1.211 0 0
DARPP-32 events R-HSA-180024 6.147212e-02 1.211 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.260525e-02 1.203 0 0
Signaling by TGFBR3 R-HSA-9839373 6.260525e-02 1.203 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.170656e-02 1.144 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 7.170656e-02 1.144 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.635140e-02 1.178 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 6.635140e-02 1.178 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.327234e-02 1.199 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.262271e-02 1.139 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.262271e-02 1.139 0 0
mRNA Splicing R-HSA-72172 6.784859e-02 1.168 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.976686e-02 1.156 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.635140e-02 1.178 0 0
Muscle contraction R-HSA-397014 6.985441e-02 1.156 0 0
Rap1 signalling R-HSA-392517 7.005689e-02 1.155 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 6.783390e-02 1.169 0 0
Post NMDA receptor activation events R-HSA-438064 7.260000e-02 1.139 0 0
FLT3 signaling in disease R-HSA-9682385 7.586911e-02 1.120 0 0
Developmental Biology R-HSA-1266738 7.082850e-02 1.150 1 0
G1/S-Specific Transcription R-HSA-69205 7.586911e-02 1.120 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.680077e-02 1.115 0 0
DCC mediated attractive signaling R-HSA-418885 7.924046e-02 1.101 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.924046e-02 1.101 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 7.924046e-02 1.101 0 0
p75NTR signals via NF-kB R-HSA-193639 7.924046e-02 1.101 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 7.924046e-02 1.101 0 0
Cell-extracellular matrix interactions R-HSA-446353 7.924046e-02 1.101 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.036162e-02 1.095 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.073689e-02 1.093 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.077369e-02 1.093 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.077369e-02 1.093 0 0
Interleukin-7 signaling R-HSA-1266695 8.077369e-02 1.093 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 8.137689e-02 1.089 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.305044e-02 1.081 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.305044e-02 1.081 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 8.305044e-02 1.081 0 0
Potassium transport channels R-HSA-1296067 8.305044e-02 1.081 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.305044e-02 1.081 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.305044e-02 1.081 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.305044e-02 1.081 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.305044e-02 1.081 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.305044e-02 1.081 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.305044e-02 1.081 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.305044e-02 1.081 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.305044e-02 1.081 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.305044e-02 1.081 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.598018e-02 1.066 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.797472e-02 1.056 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.817961e-02 1.055 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.831163e-02 1.054 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.831163e-02 1.054 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.831163e-02 1.054 0 0
Signaling by SCF-KIT R-HSA-1433557 8.859228e-02 1.053 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.864472e-02 1.052 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.157639e-02 1.038 0 0
TRP channels R-HSA-3295583 9.157639e-02 1.038 0 0
Metalloprotease DUBs R-HSA-5689901 9.157639e-02 1.038 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.351553e-02 1.029 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.361599e-02 1.029 0 0
Nef and signal transduction R-HSA-164944 9.384417e-02 1.028 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.122364e-01 0.950 0 0
KIT mutants bind TKIs R-HSA-9669921 1.122364e-01 0.950 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.122364e-01 0.950 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.122364e-01 0.950 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.122364e-01 0.950 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.122364e-01 0.950 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.122364e-01 0.950 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.122364e-01 0.950 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.122364e-01 0.950 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.063305e-01 0.973 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.855855e-02 1.006 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.094461e-01 0.961 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.085624e-01 0.964 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.177318e-01 0.929 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.086870e-01 0.964 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.177318e-01 0.929 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.085261e-01 0.964 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.499236e-02 1.022 0 0
Ca2+ pathway R-HSA-4086398 1.103532e-01 0.957 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 9.855855e-02 1.006 0 0
DNA Repair R-HSA-73894 1.089577e-01 0.963 0 0
DAG and IP3 signaling R-HSA-1489509 1.065169e-01 0.973 0 0
MAPK family signaling cascades R-HSA-5683057 1.176995e-01 0.929 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.155028e-01 0.937 0 0
Diseases of DNA repair R-HSA-9675135 1.162040e-01 0.935 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.183968e-01 0.927 0 0
Netrin mediated repulsion signals R-HSA-418886 1.183968e-01 0.927 0 0
SOS-mediated signalling R-HSA-112412 1.183968e-01 0.927 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.183968e-01 0.927 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 1.183968e-01 0.927 0 0
Regulation of PTEN localization R-HSA-8948747 1.183968e-01 0.927 0 0
G1/S Transition R-HSA-69206 1.196225e-01 0.922 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.203128e-01 0.920 0 0
Nuclear import of Rev protein R-HSA-180746 1.209626e-01 0.917 0 0
mTORC1-mediated signalling R-HSA-166208 1.209845e-01 0.917 0 0
HCMV Early Events R-HSA-9609690 1.218963e-01 0.914 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.219109e-01 0.914 0 0
Signaling by Hippo R-HSA-2028269 1.251445e-01 0.903 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.260157e-01 0.900 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.260157e-01 0.900 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.260157e-01 0.900 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.260157e-01 0.900 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.260157e-01 0.900 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.260157e-01 0.900 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.260157e-01 0.900 0 0
Regulated Necrosis R-HSA-5218859 1.271942e-01 0.896 0 0
Late endosomal microautophagy R-HSA-9615710 1.285219e-01 0.891 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.298096e-01 0.887 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.303478e-01 0.885 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.328901e-01 0.877 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.329977e-01 0.876 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.330923e-01 0.876 0 0
UCH proteinases R-HSA-5689603 1.349542e-01 0.870 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.353320e-01 0.869 0 0
PI Metabolism R-HSA-1483255 1.353320e-01 0.869 0 0
Regulation of gap junction activity R-HSA-191650 1.607640e-01 0.794 0 0
HCN channels R-HSA-1296061 1.607640e-01 0.794 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.607640e-01 0.794 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.607640e-01 0.794 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.607640e-01 0.794 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.607640e-01 0.794 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 1.450279e-01 0.839 0 0
Interleukin-1 processing R-HSA-448706 1.733920e-01 0.761 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.470995e-01 0.832 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.470995e-01 0.832 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.470995e-01 0.832 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.470995e-01 0.832 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.426710e-01 0.846 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.611890e-01 0.793 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.806132e-01 0.743 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.806132e-01 0.743 0 0
Activation of the pre-replicative complex R-HSA-68962 1.422793e-01 0.847 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.729515e-01 0.762 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 1.697611e-01 0.770 0 0
snRNP Assembly R-HSA-191859 1.813314e-01 0.742 0 0
Metabolism of non-coding RNA R-HSA-194441 1.813314e-01 0.742 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.426710e-01 0.846 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.591109e-01 0.798 0 0
Polo-like kinase mediated events R-HSA-156711 1.426710e-01 0.846 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.733920e-01 0.761 0 0
GAB1 signalosome R-HSA-180292 1.426710e-01 0.846 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.694334e-01 0.771 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.607640e-01 0.794 0 0
Dopamine receptors R-HSA-390651 1.607640e-01 0.794 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.733920e-01 0.761 0 0
cGMP effects R-HSA-418457 1.694334e-01 0.771 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.426710e-01 0.846 0 0
MTOR signalling R-HSA-165159 1.475535e-01 0.831 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.729515e-01 0.762 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.526272e-01 0.816 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 1.683670e-01 0.774 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.591109e-01 0.798 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.607640e-01 0.794 0 0
Metabolism of RNA R-HSA-8953854 1.407947e-01 0.851 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.458159e-01 0.836 0 0
Calmodulin induced events R-HSA-111933 1.458159e-01 0.836 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.450279e-01 0.839 0 0
Unwinding of DNA R-HSA-176974 1.733920e-01 0.761 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.470995e-01 0.832 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.426710e-01 0.846 0 0
Protein hydroxylation R-HSA-9629569 1.806132e-01 0.743 0 0
CaM pathway R-HSA-111997 1.458159e-01 0.836 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.595297e-01 0.797 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.470995e-01 0.832 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.570110e-01 0.804 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.713715e-01 0.766 0 0
HCMV Late Events R-HSA-9610379 1.519498e-01 0.818 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.426710e-01 0.846 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.607640e-01 0.794 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.754157e-01 0.756 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.856701e-01 0.731 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.694334e-01 0.771 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.477494e-01 0.830 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.859046e-01 0.731 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.873091e-01 0.727 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.873091e-01 0.727 0 0
Cardiogenesis R-HSA-9733709 1.874479e-01 0.727 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.874479e-01 0.727 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.874479e-01 0.727 0 0
Peptide chain elongation R-HSA-156902 1.880474e-01 0.726 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.896444e-01 0.722 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.928604e-01 0.715 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.928604e-01 0.715 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.928604e-01 0.715 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.929962e-01 0.714 0 0
Stimuli-sensing channels R-HSA-2672351 1.929962e-01 0.714 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.118817e-01 0.674 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.118817e-01 0.674 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.118817e-01 0.674 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.118817e-01 0.674 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.003476e-01 0.522 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.003476e-01 0.522 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.003476e-01 0.522 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.003476e-01 0.522 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.003476e-01 0.522 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.003476e-01 0.522 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.003476e-01 0.522 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.003476e-01 0.522 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.003476e-01 0.522 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.003476e-01 0.522 0 0
Defective GALK1 causes GALCT2 R-HSA-5609976 3.003476e-01 0.522 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.003476e-01 0.522 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.003476e-01 0.522 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.003476e-01 0.522 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.003476e-01 0.522 0 0
Intestinal infectious diseases R-HSA-8942233 3.003476e-01 0.522 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.032197e-01 0.692 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.032197e-01 0.692 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.032197e-01 0.692 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.032197e-01 0.692 0 0
IRS activation R-HSA-74713 2.032197e-01 0.692 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.032197e-01 0.692 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.032197e-01 0.692 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.032197e-01 0.692 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.467211e-01 0.608 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.467211e-01 0.608 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.467211e-01 0.608 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.467211e-01 0.608 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.467211e-01 0.608 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.467211e-01 0.608 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.788879e-01 0.421 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.788879e-01 0.421 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.788879e-01 0.421 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.788879e-01 0.421 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.788879e-01 0.421 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.788879e-01 0.421 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.788879e-01 0.421 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.788879e-01 0.421 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.788879e-01 0.421 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.904991e-01 0.537 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.904991e-01 0.537 0 0
STAT5 Activation R-HSA-9645135 2.904991e-01 0.537 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 2.904991e-01 0.537 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.904991e-01 0.537 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.339610e-01 0.631 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.339610e-01 0.631 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.339610e-01 0.631 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.339610e-01 0.631 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.655239e-01 0.576 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.655239e-01 0.576 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.339439e-01 0.476 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.339439e-01 0.476 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 3.339439e-01 0.476 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 3.339439e-01 0.476 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.339439e-01 0.476 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 4.486156e-01 0.348 0 0
MET activates PTPN11 R-HSA-8865999 4.486156e-01 0.348 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.486156e-01 0.348 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.486156e-01 0.348 0 0
Invadopodia formation R-HSA-8941237 4.486156e-01 0.348 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.486156e-01 0.348 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.486156e-01 0.348 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.486156e-01 0.348 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.423474e-01 0.616 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.036316e-01 0.691 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.036316e-01 0.691 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.036316e-01 0.691 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.036316e-01 0.691 0 0
Regulation by c-FLIP R-HSA-3371378 3.765790e-01 0.424 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.765790e-01 0.424 0 0
Dimerization of procaspase-8 R-HSA-69416 3.765790e-01 0.424 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.765790e-01 0.424 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.765790e-01 0.424 0 0
HIV elongation arrest and recovery R-HSA-167287 2.221885e-01 0.653 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.221885e-01 0.653 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.942745e-01 0.531 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.942745e-01 0.531 0 0
HIV Transcription Elongation R-HSA-167169 2.021528e-01 0.694 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.021528e-01 0.694 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.021528e-01 0.694 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.608241e-01 0.584 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.880222e-01 0.541 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.207675e-01 0.494 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.207675e-01 0.494 0 0
Lipophagy R-HSA-9613354 4.180390e-01 0.379 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.180390e-01 0.379 0 0
CASP8 activity is inhibited R-HSA-5218900 4.180390e-01 0.379 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 4.180390e-01 0.379 0 0
MTF1 activates gene expression R-HSA-5660489 5.105192e-01 0.292 0 0
MPS VI - Maroteaux-Lamy syndrome R-HSA-2206285 5.105192e-01 0.292 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.105192e-01 0.292 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.807672e-01 0.552 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.807672e-01 0.552 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.474215e-01 0.459 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.474215e-01 0.459 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.474215e-01 0.459 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.474215e-01 0.459 0 0
Erythropoietin activates RAS R-HSA-9027284 3.938684e-01 0.405 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.938684e-01 0.405 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.130008e-01 0.672 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.215626e-01 0.493 0 0
Binding and entry of HIV virion R-HSA-173107 4.580505e-01 0.339 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.580505e-01 0.339 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.580505e-01 0.339 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.030612e-01 0.692 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.994441e-01 0.524 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.994441e-01 0.524 0 0
Orc1 removal from chromatin R-HSA-68949 2.894903e-01 0.538 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 4.253612e-01 0.371 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.006901e-01 0.397 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.804653e-01 0.420 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.804653e-01 0.420 0 0
Translation initiation complex formation R-HSA-72649 3.215791e-01 0.493 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.840283e-01 0.416 0 0
Signaling by KIT in disease R-HSA-9669938 4.270687e-01 0.370 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.270687e-01 0.370 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.562626e-01 0.341 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.964165e-01 0.304 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.654760e-01 0.248 0 0
Activation of AMPA receptors R-HSA-399710 5.654760e-01 0.248 0 0
Defective F9 activation R-HSA-9673221 5.654760e-01 0.248 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.654760e-01 0.248 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.654760e-01 0.248 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.654760e-01 0.248 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.406804e-01 0.468 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.080777e-01 0.511 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.049352e-01 0.393 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.049352e-01 0.393 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.268508e-01 0.370 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.268508e-01 0.370 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.268508e-01 0.370 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.870599e-01 0.412 0 0
Voltage gated Potassium channels R-HSA-1296072 4.257857e-01 0.371 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.864393e-01 0.313 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.864393e-01 0.313 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.719690e-01 0.429 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.788033e-01 0.320 0 0
Deadenylation of mRNA R-HSA-429947 4.788033e-01 0.320 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.330021e-01 0.273 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 5.330021e-01 0.273 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.330021e-01 0.273 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.254981e-01 0.487 0 0
Transcription of the HIV genome R-HSA-167172 4.188653e-01 0.378 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.403084e-01 0.356 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.039867e-01 0.298 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.467840e-01 0.350 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.616534e-01 0.336 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.928912e-01 0.307 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.169478e-01 0.287 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.677235e-01 0.246 0 0
Leading Strand Synthesis R-HSA-69109 5.677235e-01 0.246 0 0
Polymerase switching R-HSA-69091 5.677235e-01 0.246 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.677235e-01 0.246 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.677235e-01 0.246 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.677235e-01 0.246 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.677235e-01 0.246 0 0
Viral mRNA Translation R-HSA-192823 4.897238e-01 0.310 0 0
PPARA activates gene expression R-HSA-1989781 4.938925e-01 0.306 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 5.526317e-01 0.258 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.535418e-01 0.257 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.846970e-01 0.233 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 5.148944e-01 0.288 0 0
RNA Polymerase III Transcription R-HSA-74158 4.049352e-01 0.393 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.331630e-01 0.632 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.288832e-01 0.483 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.288832e-01 0.483 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.268508e-01 0.370 0 0
EGFR downregulation R-HSA-182971 2.807672e-01 0.552 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.100989e-01 0.508 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.286164e-01 0.277 0 0
Ribosome-associated quality control R-HSA-9948299 5.737105e-01 0.241 0 0
Aggrephagy R-HSA-9646399 3.288832e-01 0.483 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.562626e-01 0.341 0 0
Developmental Cell Lineages R-HSA-9734767 5.019897e-01 0.299 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.091356e-01 0.680 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 4.864393e-01 0.313 0 0
Myogenesis R-HSA-525793 5.286164e-01 0.277 0 0
G0 and Early G1 R-HSA-1538133 4.725161e-01 0.326 0 0
Adipogenesis R-HSA-9843745 3.048565e-01 0.516 0 0
Signaling by ERBB2 R-HSA-1227986 4.207580e-01 0.376 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.849972e-01 0.415 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.169478e-01 0.287 0 0
Hedgehog 'off' state R-HSA-5610787 4.505632e-01 0.346 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.031465e-01 0.692 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.031465e-01 0.692 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.655239e-01 0.576 0 0
MAP2K and MAPK activation R-HSA-5674135 2.331630e-01 0.632 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.580505e-01 0.339 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.874655e-01 0.412 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.949146e-01 0.305 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.467211e-01 0.608 0 0
Formation of apoptosome R-HSA-111458 2.031465e-01 0.692 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 2.031465e-01 0.692 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.339439e-01 0.476 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.680846e-01 0.572 0 0
Regulation of CDH11 function R-HSA-9762292 4.580505e-01 0.339 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.580505e-01 0.339 0 0
PI3K/AKT activation R-HSA-198203 4.580505e-01 0.339 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.630279e-01 0.580 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.270687e-01 0.370 0 0
Eukaryotic Translation Termination R-HSA-72764 2.861538e-01 0.543 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.722474e-01 0.429 0 0
DNA strand elongation R-HSA-69190 4.725161e-01 0.326 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.658782e-01 0.332 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.658782e-01 0.332 0 0
Intra-Golgi traffic R-HSA-6811438 5.273897e-01 0.278 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.501478e-01 0.602 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.979876e-01 0.526 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.204123e-01 0.657 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.108762e-01 0.507 0 0
G1 Phase R-HSA-69236 5.846970e-01 0.233 0 0
Cyclin D associated events in G1 R-HSA-69231 5.846970e-01 0.233 0 0
NF-kB is activated and signals survival R-HSA-209560 2.655239e-01 0.576 0 0
WNT mediated activation of DVL R-HSA-201688 4.180390e-01 0.379 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.552372e-01 0.593 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.281521e-01 0.484 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.582821e-01 0.446 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.677235e-01 0.246 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.677235e-01 0.246 0 0
S Phase R-HSA-69242 2.604111e-01 0.584 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.774538e-01 0.557 0 0
Mitophagy R-HSA-5205647 5.385659e-01 0.269 0 0
Interleukin-2 signaling R-HSA-9020558 2.339610e-01 0.631 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.501478e-01 0.602 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.174491e-01 0.663 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.502560e-01 0.347 0 0
HIV Life Cycle R-HSA-162587 3.452600e-01 0.462 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.148958e-01 0.668 0 0
Autophagy R-HSA-9612973 2.617523e-01 0.582 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.031465e-01 0.692 0 0
Signal attenuation R-HSA-74749 2.031465e-01 0.692 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.148958e-01 0.668 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.668951e-01 0.435 0 0
Apoptotic factor-mediated response R-HSA-111471 5.157806e-01 0.288 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.339618e-01 0.476 0 0
Selective autophagy R-HSA-9663891 2.712834e-01 0.567 0 0
TCR signaling R-HSA-202403 2.904504e-01 0.537 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.039867e-01 0.298 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.021528e-01 0.694 0 0
Co-stimulation by CD28 R-HSA-389356 2.283010e-01 0.641 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.099634e-01 0.509 0 0
Abacavir transmembrane transport R-HSA-2161517 2.904991e-01 0.537 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.339439e-01 0.476 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.608241e-01 0.584 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.880222e-01 0.541 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 4.180390e-01 0.379 0 0
Formation of the posterior neural plate R-HSA-9832991 4.964165e-01 0.304 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.654760e-01 0.248 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.151350e-01 0.502 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.184924e-01 0.378 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.536782e-01 0.343 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.385659e-01 0.269 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.731839e-01 0.242 0 0
HIV Infection R-HSA-162906 2.757916e-01 0.559 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.721347e-01 0.243 0 0
EPH-Ephrin signaling R-HSA-2682334 2.404920e-01 0.619 0 0
PTEN Regulation R-HSA-6807070 5.845177e-01 0.233 0 0
Macroautophagy R-HSA-1632852 3.359001e-01 0.474 0 0
Signaling by Hedgehog R-HSA-5358351 5.737105e-01 0.241 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.423474e-01 0.616 0 0
Signaling by WNT in cancer R-HSA-4791275 3.010360e-01 0.521 0 0
Platelet calcium homeostasis R-HSA-418360 4.037125e-01 0.394 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.814835e-01 0.551 0 0
Interleukin-1 family signaling R-HSA-446652 2.276761e-01 0.643 0 0
HCMV Infection R-HSA-9609646 3.941998e-01 0.404 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.619417e-01 0.441 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.215626e-01 0.493 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.431464e-01 0.614 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.431464e-01 0.614 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.331630e-01 0.632 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 3.668951e-01 0.435 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 3.297644e-01 0.482 0 0
Signaling by NODAL R-HSA-1181150 3.474215e-01 0.459 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.039867e-01 0.298 0 0
Glycogen metabolism R-HSA-8982491 3.288832e-01 0.483 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.904991e-01 0.537 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.904991e-01 0.537 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.765790e-01 0.424 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.608241e-01 0.584 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.474215e-01 0.459 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.562626e-01 0.341 0 0
tRNA processing in the nucleus R-HSA-6784531 4.539624e-01 0.343 0 0
Signaling by VEGF R-HSA-194138 4.037569e-01 0.394 0 0
NGF-stimulated transcription R-HSA-9031628 2.283010e-01 0.641 0 0
Hedgehog 'on' state R-HSA-5632684 4.658782e-01 0.332 0 0
Cilium Assembly R-HSA-5617833 2.904302e-01 0.537 0 0
Gastrulation R-HSA-9758941 2.694272e-01 0.570 0 0
mRNA Editing R-HSA-75072 4.180390e-01 0.379 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.169478e-01 0.287 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.441969e-01 0.264 0 0
Neuronal System R-HSA-112316 1.995401e-01 0.700 0 0
Potassium Channels R-HSA-1296071 2.979876e-01 0.526 0 0
Signaling by TGFB family members R-HSA-9006936 2.976965e-01 0.526 0 0
Host Interactions of HIV factors R-HSA-162909 2.180240e-01 0.661 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.950074e-01 0.530 0 0
PLC beta mediated events R-HSA-112043 2.055272e-01 0.687 0 0
Membrane Trafficking R-HSA-199991 3.659143e-01 0.437 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.118817e-01 0.674 0 0
Inhibition of PKR R-HSA-169131 2.118817e-01 0.674 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.003476e-01 0.522 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.003476e-01 0.522 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.003476e-01 0.522 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.032197e-01 0.692 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.788879e-01 0.421 0 0
C6 deamination of adenosine R-HSA-75102 3.788879e-01 0.421 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.788879e-01 0.421 0 0
Signaling by APC mutants R-HSA-4839744 2.339610e-01 0.631 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.172192e-01 0.663 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.655239e-01 0.576 0 0
Signaling by AXIN mutants R-HSA-4839735 2.655239e-01 0.576 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.655239e-01 0.576 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.339439e-01 0.476 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.486156e-01 0.348 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.486156e-01 0.348 0 0
The IPAF inflammasome R-HSA-844623 4.486156e-01 0.348 0 0
Disorders of Developmental Biology R-HSA-9675151 2.423474e-01 0.616 0 0
Signaling by LTK R-HSA-9842663 2.975462e-01 0.526 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.297644e-01 0.482 0 0
The NLRP3 inflammasome R-HSA-844456 3.207675e-01 0.494 0 0
Alanine metabolism R-HSA-8964540 5.105192e-01 0.292 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.105192e-01 0.292 0 0
Transmission across Electrical Synapses R-HSA-112307 5.105192e-01 0.292 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.105192e-01 0.292 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.105192e-01 0.292 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.580505e-01 0.339 0 0
Phase 4 - resting membrane potential R-HSA-5576886 4.253612e-01 0.371 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.631230e-01 0.440 0 0
Ethanol oxidation R-HSA-71384 4.270687e-01 0.370 0 0
Suppression of autophagy R-HSA-9636569 5.654760e-01 0.248 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.531370e-01 0.344 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.257857e-01 0.371 0 0
Sodium/Calcium exchangers R-HSA-425561 5.330021e-01 0.273 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.433539e-01 0.353 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.874666e-01 0.312 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.676398e-01 0.330 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.677235e-01 0.246 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.979876e-01 0.526 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.100989e-01 0.508 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.704613e-01 0.327 0 0
Signaling by PTK6 R-HSA-8848021 4.704613e-01 0.327 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.578770e-01 0.339 0 0
Signalling to ERKs R-HSA-187687 5.597250e-01 0.252 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.824375e-01 0.549 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.814212e-01 0.317 0 0
Ca-dependent events R-HSA-111996 2.492578e-01 0.603 0 0
Protein methylation R-HSA-8876725 3.938684e-01 0.405 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.874666e-01 0.312 0 0
Opioid Signalling R-HSA-111885 2.172104e-01 0.663 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.031465e-01 0.692 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.765790e-01 0.424 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.180390e-01 0.379 0 0
Rab regulation of trafficking R-HSA-9007101 2.241647e-01 0.649 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.654760e-01 0.248 0 0
Selenocysteine synthesis R-HSA-2408557 3.590242e-01 0.445 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.070501e-01 0.390 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.677235e-01 0.246 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.526317e-01 0.258 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.382587e-01 0.358 0 0
G-protein mediated events R-HSA-112040 2.852683e-01 0.545 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.768690e-01 0.239 0 0
Signaling by ERBB4 R-HSA-1236394 3.871092e-01 0.412 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.467211e-01 0.608 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.975462e-01 0.526 0 0
Pervasive developmental disorders R-HSA-9005895 2.975462e-01 0.526 0 0
Disorders of Nervous System Development R-HSA-9697154 2.975462e-01 0.526 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.433917e-01 0.614 0 0
Processing of SMDT1 R-HSA-8949664 3.297644e-01 0.482 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.180390e-01 0.379 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.180390e-01 0.379 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.180390e-01 0.379 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.180390e-01 0.379 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.938684e-01 0.405 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.422800e-01 0.466 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.166756e-01 0.499 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.006901e-01 0.397 0 0
Inflammasomes R-HSA-622312 5.759813e-01 0.240 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.180390e-01 0.379 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.172104e-01 0.663 0 0
Formation of the nephric duct R-HSA-9830364 5.039867e-01 0.298 0 0
Signaling by NTRKs R-HSA-166520 4.196338e-01 0.377 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.788033e-01 0.320 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.281521e-01 0.484 0 0
Generation of second messenger molecules R-HSA-202433 2.021528e-01 0.694 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.531370e-01 0.344 0 0
Glycolysis R-HSA-70171 2.550752e-01 0.593 0 0
Diseases of cellular response to stress R-HSA-9675132 3.788879e-01 0.421 0 0
Diseases of Cellular Senescence R-HSA-9630747 3.788879e-01 0.421 0 0
DSCAM interactions R-HSA-376172 3.788879e-01 0.421 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.031465e-01 0.692 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.486156e-01 0.348 0 0
Maturation of nucleoprotein R-HSA-9683610 3.297644e-01 0.482 0 0
Sensory perception of sour taste R-HSA-9729555 5.105192e-01 0.292 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.741034e-01 0.427 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.100989e-01 0.508 0 0
Negative regulation of FLT3 R-HSA-9706369 4.253612e-01 0.371 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.253612e-01 0.371 0 0
Synthesis of PI R-HSA-1483226 4.964165e-01 0.304 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.677235e-01 0.246 0 0
Ion channel transport R-HSA-983712 2.820884e-01 0.550 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.472687e-01 0.349 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.468694e-01 0.262 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.273630e-01 0.278 0 0
Sensory processing of sound R-HSA-9659379 2.429791e-01 0.614 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.433539e-01 0.353 0 0
Signal regulatory protein family interactions R-HSA-391160 3.619417e-01 0.441 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.036738e-01 0.691 0 0
Signaling by ALK in cancer R-HSA-9700206 4.472687e-01 0.349 0 0
Ion transport by P-type ATPases R-HSA-936837 2.442017e-01 0.612 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.571874e-01 0.447 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.904991e-01 0.537 0 0
PECAM1 interactions R-HSA-210990 2.339610e-01 0.631 0 0
Histamine receptors R-HSA-390650 4.486156e-01 0.348 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.218111e-01 0.654 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.011716e-01 0.696 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.270687e-01 0.370 0 0
Tie2 Signaling R-HSA-210993 5.157806e-01 0.288 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.997065e-01 0.301 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.036316e-01 0.691 0 0
L1CAM interactions R-HSA-373760 3.819884e-01 0.418 0 0
Glucose metabolism R-HSA-70326 3.937641e-01 0.405 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.938684e-01 0.405 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.169635e-01 0.287 0 0
Formation of the anterior neural plate R-HSA-9823739 3.938684e-01 0.405 0 0
The AIM2 inflammasome R-HSA-844615 3.788879e-01 0.421 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.788879e-01 0.421 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.339439e-01 0.476 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.339439e-01 0.476 0 0
Sodium/Proton exchangers R-HSA-425986 3.765790e-01 0.424 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.180390e-01 0.379 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.105192e-01 0.292 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.580505e-01 0.339 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.654760e-01 0.248 0 0
Co-inhibition by BTLA R-HSA-9927353 5.654760e-01 0.248 0 0
NrCAM interactions R-HSA-447038 5.654760e-01 0.248 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.874666e-01 0.312 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.075764e-01 0.294 0 0
Estrogen biosynthesis R-HSA-193144 5.677235e-01 0.246 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.716488e-01 0.243 0 0
Platelet sensitization by LDL R-HSA-432142 5.157806e-01 0.288 0 0
Signaling by ALK R-HSA-201556 4.671013e-01 0.331 0 0
Maturation of nucleoprotein R-HSA-9694631 5.441969e-01 0.264 0 0
Signaling by Leptin R-HSA-2586552 2.031465e-01 0.692 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.270687e-01 0.370 0 0
Pyroptosis R-HSA-5620971 3.804653e-01 0.420 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.467211e-01 0.608 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.339439e-01 0.476 0 0
FasL/ CD95L signaling R-HSA-75157 4.486156e-01 0.348 0 0
OAS antiviral response R-HSA-8983711 2.975462e-01 0.526 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.180390e-01 0.379 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.938684e-01 0.405 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.964165e-01 0.304 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.654760e-01 0.248 0 0
Influenza Infection R-HSA-168255 4.110244e-01 0.386 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.942745e-01 0.531 0 0
Interleukin-15 signaling R-HSA-8983432 5.677235e-01 0.246 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.330021e-01 0.273 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.984560e-01 0.525 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 2.172192e-01 0.663 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.157806e-01 0.288 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.865972e-01 0.232 0 0
Smooth Muscle Contraction R-HSA-445355 5.888698e-01 0.230 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.979888e-01 0.223 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.979888e-01 0.223 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.979888e-01 0.223 0 0
Signalling to RAS R-HSA-167044 5.979888e-01 0.223 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.979888e-01 0.223 0 0
Signaling by Erythropoietin R-HSA-9006335 5.986228e-01 0.223 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.986228e-01 0.223 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.986228e-01 0.223 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 5.986228e-01 0.223 0 0
Acetylcholine binding and downstream events R-HSA-181431 6.005382e-01 0.221 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 6.005382e-01 0.221 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.005382e-01 0.221 0 0
Frs2-mediated activation R-HSA-170968 6.005382e-01 0.221 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 6.005382e-01 0.221 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.005382e-01 0.221 0 0
Cellular response to starvation R-HSA-9711097 6.126653e-01 0.213 0 0
Plus-strand DNA synthesis R-HSA-164525 6.142654e-01 0.212 0 0
PKB-mediated events R-HSA-109703 6.142654e-01 0.212 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.142654e-01 0.212 0 0
PDE3B signalling R-HSA-165160 6.142654e-01 0.212 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.142654e-01 0.212 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.142654e-01 0.212 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.142654e-01 0.212 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.142654e-01 0.212 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.142654e-01 0.212 0 0
Signaling by MAPK mutants R-HSA-9652817 6.142654e-01 0.212 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.142654e-01 0.212 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.142654e-01 0.212 0 0
NGF-independant TRKA activation R-HSA-187024 6.142654e-01 0.212 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.142654e-01 0.212 0 0
Formation of the Editosome R-HSA-75094 6.142654e-01 0.212 0 0
Phosphorylation of Emi1 R-HSA-176417 6.142654e-01 0.212 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.142654e-01 0.212 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.142654e-01 0.212 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.142654e-01 0.212 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.142654e-01 0.212 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.142654e-01 0.212 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.142654e-01 0.212 0 0
TRAIL signaling R-HSA-75158 6.142654e-01 0.212 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.142654e-01 0.212 0 0
DAP12 signaling R-HSA-2424491 6.205222e-01 0.207 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.208336e-01 0.207 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.232729e-01 0.205 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.232729e-01 0.205 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.232729e-01 0.205 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.232729e-01 0.205 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.294764e-01 0.201 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.306072e-01 0.200 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.314366e-01 0.200 0 0
Removal of the Flap Intermediate R-HSA-69166 6.314366e-01 0.200 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.314366e-01 0.200 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.314366e-01 0.200 0 0
Physiological factors R-HSA-5578768 6.314366e-01 0.200 0 0
P2Y receptors R-HSA-417957 6.314366e-01 0.200 0 0
Recycling pathway of L1 R-HSA-437239 6.382124e-01 0.195 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.383426e-01 0.195 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.390805e-01 0.194 0 0
Stabilization of p53 R-HSA-69541 6.390805e-01 0.194 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 6.390805e-01 0.194 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.390970e-01 0.194 0 0
Signaling by FGFR in disease R-HSA-1226099 6.402595e-01 0.194 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 6.416533e-01 0.193 0 0
Budding and maturation of HIV virion R-HSA-162588 6.416533e-01 0.193 0 0
Downstream signal transduction R-HSA-186763 6.416533e-01 0.193 0 0
FGFR2 alternative splicing R-HSA-6803529 6.474456e-01 0.189 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.474456e-01 0.189 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.474456e-01 0.189 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.474456e-01 0.189 0 0
Interleukin-2 family signaling R-HSA-451927 6.574712e-01 0.182 0 0
Signaling by LTK in cancer R-HSA-9842640 6.575792e-01 0.182 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.575792e-01 0.182 0 0
Uncoating of the HIV Virion R-HSA-162585 6.575792e-01 0.182 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.575792e-01 0.182 0 0
NADPH regeneration R-HSA-389542 6.575792e-01 0.182 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.575792e-01 0.182 0 0
Lipid particle organization R-HSA-8964572 6.575792e-01 0.182 0 0
Neurofascin interactions R-HSA-447043 6.575792e-01 0.182 0 0
Synthesis of DNA R-HSA-69239 6.585015e-01 0.181 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.604352e-01 0.180 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.604352e-01 0.180 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.604352e-01 0.180 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.604352e-01 0.180 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.604352e-01 0.180 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.604352e-01 0.180 0 0
p38MAPK events R-HSA-171007 6.604352e-01 0.180 0 0
Biotin transport and metabolism R-HSA-196780 6.604352e-01 0.180 0 0
Signaling by Activin R-HSA-1502540 6.604352e-01 0.180 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.604352e-01 0.180 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.678186e-01 0.175 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.704943e-01 0.174 0 0
Carnitine shuttle R-HSA-200425 6.704943e-01 0.174 0 0
Degradation of CDH1 R-HSA-9766229 6.715089e-01 0.173 0 0
Interleukin-1 signaling R-HSA-9020702 6.805380e-01 0.167 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.815409e-01 0.167 0 0
Integrin signaling R-HSA-354192 6.815409e-01 0.167 0 0
G-protein beta:gamma signalling R-HSA-397795 6.815409e-01 0.167 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.815409e-01 0.167 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.821987e-01 0.166 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.842031e-01 0.165 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.856747e-01 0.164 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.875712e-01 0.163 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.875712e-01 0.163 0 0
Phosphorylation of the APC/C R-HSA-176412 6.875712e-01 0.163 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.875712e-01 0.163 0 0
Prolonged ERK activation events R-HSA-169893 6.875712e-01 0.163 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.875712e-01 0.163 0 0
Fructose catabolism R-HSA-70350 6.875712e-01 0.163 0 0
Regulation of BACH1 activity R-HSA-9708530 6.875712e-01 0.163 0 0
Differentiation of T cells R-HSA-9945266 6.875712e-01 0.163 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.875712e-01 0.163 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.875712e-01 0.163 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.894569e-01 0.161 0 0
Adaptive Immune System R-HSA-1280218 6.904542e-01 0.161 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.919322e-01 0.160 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.919322e-01 0.160 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.924000e-01 0.160 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.924000e-01 0.160 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 6.924000e-01 0.160 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 6.924170e-01 0.160 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.960315e-01 0.157 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.960315e-01 0.157 0 0
Disinhibition of SNARE formation R-HSA-114516 6.960315e-01 0.157 0 0
mRNA Editing: C to U Conversion R-HSA-72200 6.960315e-01 0.157 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.960315e-01 0.157 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.960315e-01 0.157 0 0
Activation of TRKA receptors R-HSA-187015 6.960315e-01 0.157 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.960315e-01 0.157 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.960315e-01 0.157 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.960315e-01 0.157 0 0
CHL1 interactions R-HSA-447041 6.960315e-01 0.157 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.990981e-01 0.155 0 0
Striated Muscle Contraction R-HSA-390522 7.002781e-01 0.155 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.002781e-01 0.155 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.002781e-01 0.155 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.027824e-01 0.153 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.027824e-01 0.153 0 0
Potential therapeutics for SARS R-HSA-9679191 7.041485e-01 0.152 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.053920e-01 0.152 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.089217e-01 0.149 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.089217e-01 0.149 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.126292e-01 0.147 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 7.128970e-01 0.147 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.128970e-01 0.147 0 0
Phase 2 - plateau phase R-HSA-5576893 7.128970e-01 0.147 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.128970e-01 0.147 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.128970e-01 0.147 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.128970e-01 0.147 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.128970e-01 0.147 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.128970e-01 0.147 0 0
Coenzyme A biosynthesis R-HSA-196783 7.128970e-01 0.147 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.128970e-01 0.147 0 0
Passive transport by Aquaporins R-HSA-432047 7.128970e-01 0.147 0 0
tRNA modification in the mitochondrion R-HSA-6787450 7.128970e-01 0.147 0 0
Synthesis of PG R-HSA-1483148 7.128970e-01 0.147 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.132207e-01 0.147 0 0
Tight junction interactions R-HSA-420029 7.132207e-01 0.147 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.176426e-01 0.144 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.182073e-01 0.144 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.182073e-01 0.144 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.218480e-01 0.142 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.248100e-01 0.140 0 0
TBC/RABGAPs R-HSA-8854214 7.248100e-01 0.140 0 0
Heme signaling R-HSA-9707616 7.261800e-01 0.139 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.261800e-01 0.139 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.301678e-01 0.137 0 0
Minus-strand DNA synthesis R-HSA-164516 7.301678e-01 0.137 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.301678e-01 0.137 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.301678e-01 0.137 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.301678e-01 0.137 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.301678e-01 0.137 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.301678e-01 0.137 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.301678e-01 0.137 0 0
Adrenoceptors R-HSA-390696 7.301678e-01 0.137 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.301678e-01 0.137 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.301678e-01 0.137 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.301678e-01 0.137 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.301678e-01 0.137 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.301678e-01 0.137 0 0
Alpha-defensins R-HSA-1462054 7.301678e-01 0.137 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.301678e-01 0.137 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.301678e-01 0.137 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.301678e-01 0.137 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.311413e-01 0.136 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.319805e-01 0.136 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.329199e-01 0.135 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.329199e-01 0.135 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.329199e-01 0.135 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.329199e-01 0.135 0 0
Regulation of Apoptosis R-HSA-169911 7.353319e-01 0.134 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.353319e-01 0.134 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.353319e-01 0.134 0 0
Oncogene Induced Senescence R-HSA-2559585 7.353319e-01 0.134 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.364769e-01 0.133 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.364769e-01 0.133 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.364769e-01 0.133 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.364769e-01 0.133 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.364769e-01 0.133 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.364769e-01 0.133 0 0
Cellular response to chemical stress R-HSA-9711123 7.377184e-01 0.132 0 0
Amine ligand-binding receptors R-HSA-375280 7.400651e-01 0.131 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.457956e-01 0.127 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.515355e-01 0.124 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.515355e-01 0.124 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.515355e-01 0.124 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.515355e-01 0.124 0 0
GPVI-mediated activation cascade R-HSA-114604 7.516594e-01 0.124 0 0
RUNX2 regulates bone development R-HSA-8941326 7.516594e-01 0.124 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.536120e-01 0.123 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.546900e-01 0.122 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.546900e-01 0.122 0 0
Signaling by NOTCH4 R-HSA-9013694 7.582315e-01 0.120 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.583837e-01 0.120 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.583837e-01 0.120 0 0
PKA activation R-HSA-163615 7.583837e-01 0.120 0 0
PKA activation in glucagon signalling R-HSA-164378 7.583837e-01 0.120 0 0
Mismatch Repair R-HSA-5358508 7.583837e-01 0.120 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.583837e-01 0.120 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.583837e-01 0.120 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 7.583837e-01 0.120 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.590892e-01 0.120 0 0
ALK mutants bind TKIs R-HSA-9700645 7.604723e-01 0.119 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.604723e-01 0.119 0 0
ARMS-mediated activation R-HSA-170984 7.604723e-01 0.119 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.604723e-01 0.119 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.604723e-01 0.119 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.604723e-01 0.119 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.604723e-01 0.119 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.604723e-01 0.119 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 7.604723e-01 0.119 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.604723e-01 0.119 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.604723e-01 0.119 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.616175e-01 0.118 0 0
Circadian clock R-HSA-9909396 7.670912e-01 0.115 0 0
Degradation of DVL R-HSA-4641258 7.672009e-01 0.115 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 7.672009e-01 0.115 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.672009e-01 0.115 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.686903e-01 0.114 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.686903e-01 0.114 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.686903e-01 0.114 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.686903e-01 0.114 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.690937e-01 0.114 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.690937e-01 0.114 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.690937e-01 0.114 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.695467e-01 0.114 0 0
Signaling by Interleukins R-HSA-449147 7.695799e-01 0.114 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.713605e-01 0.113 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.753938e-01 0.110 0 0
Pyrimidine biosynthesis R-HSA-500753 7.786956e-01 0.109 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.786956e-01 0.109 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.786956e-01 0.109 0 0
Other interleukin signaling R-HSA-449836 7.786956e-01 0.109 0 0
Interleukin-12 signaling R-HSA-9020591 7.804747e-01 0.108 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.820738e-01 0.107 0 0
IRS-mediated signalling R-HSA-112399 7.841265e-01 0.106 0 0
Regulation of CDH1 Function R-HSA-9764561 7.841265e-01 0.106 0 0
mRNA Capping R-HSA-72086 7.856249e-01 0.105 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.856249e-01 0.105 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.856249e-01 0.105 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 7.873749e-01 0.104 0 0
DNA replication initiation R-HSA-68952 7.873749e-01 0.104 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.873749e-01 0.104 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.873749e-01 0.104 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.873749e-01 0.104 0 0
Metabolism of serotonin R-HSA-380612 7.873749e-01 0.104 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.873749e-01 0.104 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.873749e-01 0.104 0 0
Pexophagy R-HSA-9664873 7.873749e-01 0.104 0 0
Maturation of spike protein R-HSA-9683686 7.873749e-01 0.104 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.873749e-01 0.104 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.873749e-01 0.104 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.873749e-01 0.104 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.873749e-01 0.104 0 0
Josephin domain DUBs R-HSA-5689877 7.873749e-01 0.104 0 0
Serotonin receptors R-HSA-390666 7.873749e-01 0.104 0 0
rRNA processing R-HSA-72312 7.936391e-01 0.100 0 0
Metal ion SLC transporters R-HSA-425410 7.948505e-01 0.100 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.974945e-01 0.098 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.974945e-01 0.098 0 0
Signal transduction by L1 R-HSA-445144 7.974945e-01 0.098 0 0
Transmission across Chemical Synapses R-HSA-112315 7.986099e-01 0.098 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.994327e-01 0.097 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.011629e-01 0.096 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.038291e-01 0.095 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.038291e-01 0.095 0 0
Neutrophil degranulation R-HSA-6798695 8.041968e-01 0.095 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.061248e-01 0.094 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.092654e-01 0.092 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.092654e-01 0.092 0 0
ChREBP activates metabolic gene expression R-HSA-163765 8.112574e-01 0.091 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.112574e-01 0.091 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.112574e-01 0.091 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.112574e-01 0.091 0 0
vRNP Assembly R-HSA-192905 8.112574e-01 0.091 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.112574e-01 0.091 0 0
Bicarbonate transporters R-HSA-425381 8.112574e-01 0.091 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.112574e-01 0.091 0 0
Transport of RCbl within the body R-HSA-9758890 8.112574e-01 0.091 0 0
LGI-ADAM interactions R-HSA-5682910 8.112574e-01 0.091 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.112574e-01 0.091 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.126595e-01 0.090 0 0
Selenoamino acid metabolism R-HSA-2408522 8.144920e-01 0.089 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.148639e-01 0.089 0 0
Lagging Strand Synthesis R-HSA-69186 8.148639e-01 0.089 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.148639e-01 0.089 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.148639e-01 0.089 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.148639e-01 0.089 0 0
Basigin interactions R-HSA-210991 8.148639e-01 0.089 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.157442e-01 0.088 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.157442e-01 0.088 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.162767e-01 0.088 0 0
PI3K Cascade R-HSA-109704 8.186310e-01 0.087 0 0
PKR-mediated signaling R-HSA-9833482 8.203793e-01 0.086 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.203793e-01 0.086 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.204925e-01 0.086 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.218304e-01 0.085 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.218304e-01 0.085 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.218304e-01 0.085 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.218304e-01 0.085 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.218304e-01 0.085 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.218304e-01 0.085 0 0
MHC class II antigen presentation R-HSA-2132295 8.276718e-01 0.082 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.281878e-01 0.082 0 0
Platelet homeostasis R-HSA-418346 8.284147e-01 0.082 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.294069e-01 0.081 0 0
The phototransduction cascade R-HSA-2514856 8.296624e-01 0.081 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.308878e-01 0.080 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.308878e-01 0.080 0 0
Downstream TCR signaling R-HSA-202424 8.312338e-01 0.080 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.324585e-01 0.080 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.324585e-01 0.080 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.324585e-01 0.080 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.324585e-01 0.080 0 0
Plasmalogen biosynthesis R-HSA-75896 8.324585e-01 0.080 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.324585e-01 0.080 0 0
ERKs are inactivated R-HSA-202670 8.324585e-01 0.080 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.324585e-01 0.080 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.324585e-01 0.080 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.324585e-01 0.080 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.324585e-01 0.080 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.324585e-01 0.080 0 0
Integration of provirus R-HSA-162592 8.324585e-01 0.080 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.337036e-01 0.079 0 0
HIV Transcription Initiation R-HSA-167161 8.337036e-01 0.079 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.337036e-01 0.079 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.337036e-01 0.079 0 0
Translation of Structural Proteins R-HSA-9683701 8.337036e-01 0.079 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.380036e-01 0.077 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.401414e-01 0.076 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.401414e-01 0.076 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.414878e-01 0.075 0 0
Interferon gamma signaling R-HSA-877300 8.421660e-01 0.075 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.449085e-01 0.073 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.456491e-01 0.073 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.456491e-01 0.073 0 0
Fructose metabolism R-HSA-5652084 8.456491e-01 0.073 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.456491e-01 0.073 0 0
IRE1alpha activates chaperones R-HSA-381070 8.473385e-01 0.072 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.473616e-01 0.072 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.500844e-01 0.071 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.512793e-01 0.070 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.512793e-01 0.070 0 0
MET activates RAS signaling R-HSA-8851805 8.512793e-01 0.070 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.512793e-01 0.070 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.512793e-01 0.070 0 0
Regulation of IFNG signaling R-HSA-877312 8.512793e-01 0.070 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.539448e-01 0.069 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.541357e-01 0.068 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.541357e-01 0.068 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.544409e-01 0.068 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.554697e-01 0.068 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.554697e-01 0.068 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.559829e-01 0.068 0 0
Insulin receptor signalling cascade R-HSA-74751 8.562742e-01 0.067 0 0
IGF1R signaling cascade R-HSA-2428924 8.562742e-01 0.067 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.592293e-01 0.066 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.592293e-01 0.066 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.592293e-01 0.066 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.592293e-01 0.066 0 0
Syndecan interactions R-HSA-3000170 8.592293e-01 0.066 0 0
Growth hormone receptor signaling R-HSA-982772 8.592293e-01 0.066 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.647541e-01 0.063 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.652828e-01 0.063 0 0
RA biosynthesis pathway R-HSA-5365859 8.652828e-01 0.063 0 0
DAP12 interactions R-HSA-2172127 8.654126e-01 0.063 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.679868e-01 0.061 0 0
Chylomicron remodeling R-HSA-8963901 8.679868e-01 0.061 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.679868e-01 0.061 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.679868e-01 0.061 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.679868e-01 0.061 0 0
Interleukin-6 signaling R-HSA-1059683 8.679868e-01 0.061 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.679868e-01 0.061 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.679868e-01 0.061 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.679868e-01 0.061 0 0
SARS-CoV Infections R-HSA-9679506 8.688705e-01 0.061 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.694177e-01 0.061 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.717074e-01 0.060 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.717074e-01 0.060 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.717074e-01 0.060 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.717074e-01 0.060 0 0
Interleukin-6 family signaling R-HSA-6783589 8.717074e-01 0.060 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.747625e-01 0.058 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.747625e-01 0.058 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.747625e-01 0.058 0 0
Somitogenesis R-HSA-9824272 8.747625e-01 0.058 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.756725e-01 0.058 0 0
PERK regulates gene expression R-HSA-381042 8.756725e-01 0.058 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.764208e-01 0.057 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.764208e-01 0.057 0 0
Vesicle-mediated transport R-HSA-5653656 8.774635e-01 0.057 0 0
Viral Infection Pathways R-HSA-9824446 8.797398e-01 0.056 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.828182e-01 0.054 0 0
HDL assembly R-HSA-8963896 8.828182e-01 0.054 0 0
The activation of arylsulfatases R-HSA-1663150 8.828182e-01 0.054 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 8.828182e-01 0.054 0 0
Prolactin receptor signaling R-HSA-1170546 8.828182e-01 0.054 0 0
Malate-aspartate shuttle R-HSA-9856872 8.828182e-01 0.054 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.828182e-01 0.054 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.828182e-01 0.054 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.828182e-01 0.054 0 0
Ciprofloxacin ADME R-HSA-9793528 8.828182e-01 0.054 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.828182e-01 0.054 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.831119e-01 0.054 0 0
Interleukin-12 family signaling R-HSA-447115 8.831119e-01 0.054 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.831596e-01 0.054 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.831596e-01 0.054 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.831596e-01 0.054 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.835453e-01 0.054 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.853448e-01 0.053 0 0
Nucleotide Excision Repair R-HSA-5696398 8.880383e-01 0.052 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.884366e-01 0.051 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.917866e-01 0.050 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.917866e-01 0.050 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.935847e-01 0.049 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.936588e-01 0.049 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.936588e-01 0.049 0 0
Abacavir ADME R-HSA-2161522 8.936588e-01 0.049 0 0
Degradation of AXIN R-HSA-4641257 8.943393e-01 0.048 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.959842e-01 0.048 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.959842e-01 0.048 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.959842e-01 0.048 0 0
Translesion synthesis by REV1 R-HSA-110312 8.959842e-01 0.048 0 0
Protein lipoylation R-HSA-9857492 8.959842e-01 0.048 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.959842e-01 0.048 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.959842e-01 0.048 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.959842e-01 0.048 0 0
Interferon Signaling R-HSA-913531 8.980693e-01 0.047 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.999193e-01 0.046 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.999193e-01 0.046 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.999193e-01 0.046 0 0
Regulation of insulin secretion R-HSA-422356 8.999193e-01 0.046 0 0
MET promotes cell motility R-HSA-8875878 9.026945e-01 0.044 0 0
Elastic fibre formation R-HSA-1566948 9.026945e-01 0.044 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.026945e-01 0.044 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.032746e-01 0.044 0 0
Cristae formation R-HSA-8949613 9.032746e-01 0.044 0 0
Triglyceride biosynthesis R-HSA-75109 9.032746e-01 0.044 0 0
Synthesis of PE R-HSA-1483213 9.032746e-01 0.044 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.040499e-01 0.044 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.042867e-01 0.044 0 0
tRNA Aminoacylation R-HSA-379724 9.061587e-01 0.043 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.061587e-01 0.043 0 0
DNA Damage Bypass R-HSA-73893 9.067466e-01 0.043 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.073100e-01 0.042 0 0
Translesion synthesis by POLI R-HSA-5656121 9.076715e-01 0.042 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.076715e-01 0.042 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.076715e-01 0.042 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.076715e-01 0.042 0 0
Activation of SMO R-HSA-5635838 9.076715e-01 0.042 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.076715e-01 0.042 0 0
Killing mechanisms R-HSA-9664420 9.076715e-01 0.042 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.076715e-01 0.042 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.076715e-01 0.042 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.076715e-01 0.042 0 0
Attachment and Entry R-HSA-9678110 9.076715e-01 0.042 0 0
Atorvastatin ADME R-HSA-9754706 9.076715e-01 0.042 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.092447e-01 0.041 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.104481e-01 0.041 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.104481e-01 0.041 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.120728e-01 0.040 0 0
Telomere Extension By Telomerase R-HSA-171319 9.120728e-01 0.040 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.120728e-01 0.040 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.120728e-01 0.040 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.120728e-01 0.040 0 0
MAP kinase activation R-HSA-450294 9.124550e-01 0.040 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.148717e-01 0.039 0 0
Integration of energy metabolism R-HSA-163685 9.169397e-01 0.038 0 0
Protein folding R-HSA-391251 9.172173e-01 0.038 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.176363e-01 0.037 0 0
Diseases of Immune System R-HSA-5260271 9.176363e-01 0.037 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.176363e-01 0.037 0 0
Translesion synthesis by POLK R-HSA-5655862 9.180463e-01 0.037 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.180463e-01 0.037 0 0
Glycine degradation R-HSA-6783984 9.180463e-01 0.037 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.180463e-01 0.037 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.180463e-01 0.037 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.180463e-01 0.037 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.180463e-01 0.037 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.180463e-01 0.037 0 0
Galactose catabolism R-HSA-70370 9.180463e-01 0.037 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.180463e-01 0.037 0 0
Response to metal ions R-HSA-5660526 9.180463e-01 0.037 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.180463e-01 0.037 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.183772e-01 0.037 0 0
Signaling by PDGF R-HSA-186797 9.183772e-01 0.037 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.201158e-01 0.036 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.201158e-01 0.036 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.201158e-01 0.036 0 0
Glucagon-type ligand receptors R-HSA-420092 9.201158e-01 0.036 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.219808e-01 0.035 0 0
Inositol phosphate metabolism R-HSA-1483249 9.228383e-01 0.035 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.231775e-01 0.035 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.242941e-01 0.034 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.257508e-01 0.034 0 0
Mitochondrial protein degradation R-HSA-9837999 9.265059e-01 0.033 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.269654e-01 0.033 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 9.272558e-01 0.033 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.272558e-01 0.033 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.272558e-01 0.033 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.272558e-01 0.033 0 0
Glycogen storage diseases R-HSA-3229121 9.272558e-01 0.033 0 0
Catecholamine biosynthesis R-HSA-209905 9.272558e-01 0.033 0 0
Choline catabolism R-HSA-6798163 9.272558e-01 0.033 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 9.272558e-01 0.033 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.274621e-01 0.033 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.274621e-01 0.033 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.274621e-01 0.033 0 0
Neurotransmitter clearance R-HSA-112311 9.274621e-01 0.033 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.304552e-01 0.031 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.304552e-01 0.031 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.313019e-01 0.031 0 0
Cellular response to hypoxia R-HSA-1234174 9.340726e-01 0.030 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.341667e-01 0.030 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.341667e-01 0.030 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.354308e-01 0.029 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.354308e-01 0.029 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.354308e-01 0.029 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.354308e-01 0.029 0 0
Nephron development R-HSA-9831926 9.354308e-01 0.029 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.364046e-01 0.029 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.382281e-01 0.028 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.402811e-01 0.027 0 0
G alpha (s) signalling events R-HSA-418555 9.405502e-01 0.027 0 0
Toll-like Receptor Cascades R-HSA-168898 9.407046e-01 0.027 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.410116e-01 0.026 0 0
Signaling by FGFR4 R-HSA-5654743 9.414144e-01 0.026 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.416314e-01 0.026 0 0
ABC transporter disorders R-HSA-5619084 9.418675e-01 0.026 0 0
PCP/CE pathway R-HSA-4086400 9.418675e-01 0.026 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.426876e-01 0.026 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.426876e-01 0.026 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.426876e-01 0.026 0 0
Translesion Synthesis by POLH R-HSA-110320 9.426876e-01 0.026 0 0
Regulation of signaling by CBL R-HSA-912631 9.426876e-01 0.026 0 0
Diseases of hemostasis R-HSA-9671793 9.426876e-01 0.026 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.426876e-01 0.026 0 0
STING mediated induction of host immune responses R-HSA-1834941 9.426876e-01 0.026 0 0
Kidney development R-HSA-9830369 9.429772e-01 0.025 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.456509e-01 0.024 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.457284e-01 0.024 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.458531e-01 0.024 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.458531e-01 0.024 0 0
Proteasome assembly R-HSA-9907900 9.462723e-01 0.024 0 0
Neurotransmitter release cycle R-HSA-112310 9.489158e-01 0.023 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.491292e-01 0.023 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.491292e-01 0.023 0 0
Glycogen synthesis R-HSA-3322077 9.491292e-01 0.023 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.491292e-01 0.023 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.491292e-01 0.023 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.491292e-01 0.023 0 0
Pregnenolone biosynthesis R-HSA-196108 9.491292e-01 0.023 0 0
Melanin biosynthesis R-HSA-5662702 9.491292e-01 0.023 0 0
Nephrin family interactions R-HSA-373753 9.491292e-01 0.023 0 0
Signaling by FGFR2 R-HSA-5654738 9.493577e-01 0.023 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.507533e-01 0.022 0 0
Signaling by FGFR3 R-HSA-5654741 9.507533e-01 0.022 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.507533e-01 0.022 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.509275e-01 0.022 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.509275e-01 0.022 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.509275e-01 0.022 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.527671e-01 0.021 0 0
Dual incision in TC-NER R-HSA-6782135 9.536513e-01 0.021 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.536513e-01 0.021 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.536596e-01 0.021 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.536596e-01 0.021 0 0
Interleukin-17 signaling R-HSA-448424 9.543082e-01 0.020 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.548471e-01 0.020 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.548471e-01 0.020 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.548471e-01 0.020 0 0
ERK/MAPK targets R-HSA-198753 9.548471e-01 0.020 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.548471e-01 0.020 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.548836e-01 0.020 0 0
Dual Incision in GG-NER R-HSA-5696400 9.555456e-01 0.020 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.555456e-01 0.020 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.555456e-01 0.020 0 0
Signal amplification R-HSA-392518 9.555456e-01 0.020 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.555456e-01 0.020 0 0
Phospholipid metabolism R-HSA-1483257 9.556681e-01 0.020 0 0
Extension of Telomeres R-HSA-180786 9.572310e-01 0.019 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.572310e-01 0.019 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.583667e-01 0.018 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.586878e-01 0.018 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.597459e-01 0.018 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.597459e-01 0.018 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.597459e-01 0.018 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.599226e-01 0.018 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.599226e-01 0.018 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.599226e-01 0.018 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.599226e-01 0.018 0 0
Glutathione synthesis and recycling R-HSA-174403 9.599226e-01 0.018 0 0
Attachment and Entry R-HSA-9694614 9.599226e-01 0.018 0 0
Assembly Of The HIV Virion R-HSA-175474 9.599226e-01 0.018 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.605537e-01 0.017 0 0
Leishmania phagocytosis R-HSA-9664417 9.606170e-01 0.017 0 0
Parasite infection R-HSA-9664407 9.606170e-01 0.017 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.606170e-01 0.017 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.611862e-01 0.017 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.611862e-01 0.017 0 0
GPER1 signaling R-HSA-9634597 9.621894e-01 0.017 0 0
Gluconeogenesis R-HSA-70263 9.621894e-01 0.017 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.635640e-01 0.016 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.636358e-01 0.016 0 0
Aquaporin-mediated transport R-HSA-445717 9.636358e-01 0.016 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.644279e-01 0.016 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.644279e-01 0.016 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.644279e-01 0.016 0 0
Gap junction trafficking and regulation R-HSA-157858 9.654104e-01 0.015 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.670326e-01 0.015 0 0
NCAM1 interactions R-HSA-419037 9.670326e-01 0.015 0 0
Hemostasis R-HSA-109582 9.683057e-01 0.014 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.683712e-01 0.014 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.684269e-01 0.014 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.684269e-01 0.014 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.684269e-01 0.014 0 0
Biosynthesis of maresins R-HSA-9018682 9.684269e-01 0.014 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.684269e-01 0.014 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.684269e-01 0.014 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.684269e-01 0.014 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.684269e-01 0.014 0 0
Interleukin-20 family signaling R-HSA-8854691 9.684269e-01 0.014 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.692088e-01 0.014 0 0
Interferon alpha/beta signaling R-HSA-909733 9.694256e-01 0.013 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.710913e-01 0.013 0 0
CYP2E1 reactions R-HSA-211999 9.719766e-01 0.012 0 0
Complex III assembly R-HSA-9865881 9.719766e-01 0.012 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.719766e-01 0.012 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.719766e-01 0.012 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.719766e-01 0.012 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.719766e-01 0.012 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.719766e-01 0.012 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.719766e-01 0.012 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.719766e-01 0.012 0 0
Pentose phosphate pathway R-HSA-71336 9.730404e-01 0.012 0 0
Mitochondrial biogenesis R-HSA-1592230 9.730883e-01 0.012 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.751274e-01 0.011 0 0
G protein gated Potassium channels R-HSA-1296059 9.751274e-01 0.011 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.751274e-01 0.011 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.751274e-01 0.011 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.751274e-01 0.011 0 0
ER-Phagosome pathway R-HSA-1236974 9.752849e-01 0.011 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.756332e-01 0.011 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.758806e-01 0.011 0 0
Nucleotide biosynthesis R-HSA-8956320 9.758806e-01 0.011 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.759539e-01 0.011 0 0
ABC-family proteins mediated transport R-HSA-382556 9.775116e-01 0.010 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.778917e-01 0.010 0 0
Nicotinate metabolism R-HSA-196807 9.778917e-01 0.010 0 0
MET activates PTK2 signaling R-HSA-8874081 9.779241e-01 0.010 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.779241e-01 0.010 0 0
Urea cycle R-HSA-70635 9.779241e-01 0.010 0 0
Sphingolipid catabolism R-HSA-9845614 9.779241e-01 0.010 0 0
tRNA processing R-HSA-72306 9.785066e-01 0.009 0 0
Signaling by MET R-HSA-6806834 9.788201e-01 0.009 0 0
G alpha (z) signalling events R-HSA-418597 9.799090e-01 0.009 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.804064e-01 0.009 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.804064e-01 0.009 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.804064e-01 0.009 0 0
Signaling by BMP R-HSA-201451 9.804064e-01 0.009 0 0
Signaling by Insulin receptor R-HSA-74752 9.816678e-01 0.008 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.816678e-01 0.008 0 0
Signaling by FGFR1 R-HSA-5654736 9.816740e-01 0.008 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.816740e-01 0.008 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.820440e-01 0.008 0 0
Prednisone ADME R-HSA-9757110 9.826098e-01 0.008 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.826700e-01 0.008 0 0
Synthesis of PA R-HSA-1483166 9.832902e-01 0.007 0 0
Collagen formation R-HSA-1474290 9.842481e-01 0.007 0 0
Retinoid metabolism and transport R-HSA-975634 9.842655e-01 0.007 0 0
Thyroxine biosynthesis R-HSA-209968 9.845655e-01 0.007 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.845655e-01 0.007 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.845655e-01 0.007 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.845890e-01 0.007 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.856518e-01 0.006 0 0
Leishmania infection R-HSA-9658195 9.856908e-01 0.006 0 0
Parasitic Infection Pathways R-HSA-9824443 9.856908e-01 0.006 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.860851e-01 0.006 0 0
Peroxisomal protein import R-HSA-9033241 9.861227e-01 0.006 0 0
Triglyceride metabolism R-HSA-8979227 9.861227e-01 0.006 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.861227e-01 0.006 0 0
Mucopolysaccharidoses R-HSA-2206281 9.863014e-01 0.006 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.868039e-01 0.006 0 0
Platelet degranulation R-HSA-114608 9.869978e-01 0.006 0 0
GABA receptor activation R-HSA-977443 9.873600e-01 0.006 0 0
Metabolism of polyamines R-HSA-351202 9.873600e-01 0.006 0 0
Cargo concentration in the ER R-HSA-5694530 9.878421e-01 0.005 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.878421e-01 0.005 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.878421e-01 0.005 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.880982e-01 0.005 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.882891e-01 0.005 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.888691e-01 0.005 0 0
Iron uptake and transport R-HSA-917937 9.888691e-01 0.005 0 0
Synthesis of PC R-HSA-1483191 9.892683e-01 0.005 0 0
Signaling by FGFR R-HSA-190236 9.892881e-01 0.005 0 0
Mitochondrial protein import R-HSA-1268020 9.895242e-01 0.005 0 0
Intraflagellar transport R-HSA-5620924 9.903259e-01 0.004 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.904234e-01 0.004 0 0
Recycling of bile acids and salts R-HSA-159418 9.904234e-01 0.004 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.904234e-01 0.004 0 0
Translation of Structural Proteins R-HSA-9694635 9.906577e-01 0.004 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.912814e-01 0.004 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.912814e-01 0.004 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.913161e-01 0.004 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.915007e-01 0.004 0 0
CS/DS degradation R-HSA-2024101 9.915007e-01 0.004 0 0
Heme degradation R-HSA-189483 9.915007e-01 0.004 0 0
eNOS activation R-HSA-203615 9.924569e-01 0.003 0 0
Signaling by NOTCH2 R-HSA-1980145 9.924569e-01 0.003 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.924569e-01 0.003 0 0
Hyaluronan metabolism R-HSA-2142845 9.924569e-01 0.003 0 0
Gap junction assembly R-HSA-190861 9.924569e-01 0.003 0 0
SLC transporter disorders R-HSA-5619102 9.927191e-01 0.003 0 0
Complex IV assembly R-HSA-9864848 9.929237e-01 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.933055e-01 0.003 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.933055e-01 0.003 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.934448e-01 0.003 0 0
Metabolism of steroid hormones R-HSA-196071 9.934851e-01 0.003 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.940479e-01 0.003 0 0
Triglyceride catabolism R-HSA-163560 9.940587e-01 0.003 0 0
Glycosphingolipid transport R-HSA-9845576 9.940587e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.940587e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.940808e-01 0.003 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.943787e-01 0.002 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.947272e-01 0.002 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.947272e-01 0.002 0 0
Lysine catabolism R-HSA-71064 9.947272e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.947272e-01 0.002 0 0
Immune System R-HSA-168256 9.949331e-01 0.002 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.953206e-01 0.002 0 0
Purine salvage R-HSA-74217 9.953206e-01 0.002 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.953510e-01 0.002 0 0
Paracetamol ADME R-HSA-9753281 9.953510e-01 0.002 0 0
Signaling by NOTCH3 R-HSA-9012852 9.953510e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.955678e-01 0.002 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.958167e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.958471e-01 0.002 0 0
RAS processing R-HSA-9648002 9.958471e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.959774e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.962365e-01 0.002 0 0
Neddylation R-HSA-8951664 9.963604e-01 0.002 0 0
Pyruvate metabolism R-HSA-70268 9.965147e-01 0.002 0 0
Maturation of spike protein R-HSA-9694548 9.967293e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.967293e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.970974e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.971034e-01 0.001 0 0
GPCR downstream signalling R-HSA-388396 9.971085e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.972627e-01 0.001 0 0
Activation of GABAB receptors R-HSA-991365 9.974241e-01 0.001 0 0
GABA B receptor activation R-HSA-977444 9.974241e-01 0.001 0 0
Translation R-HSA-72766 9.974458e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.974869e-01 0.001 0 0
Defensins R-HSA-1461973 9.977141e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.977141e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.977634e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.979714e-01 0.001 0 0
Gap junction trafficking R-HSA-190828 9.979714e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.979714e-01 0.001 0 0
RSV-host interactions R-HSA-9833110 9.979764e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.981714e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.982140e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.985823e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.987419e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.987420e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.988836e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.989823e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.990163e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.990632e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.991591e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.991629e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.991629e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.993229e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.993897e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.994549e-01 0.000 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.994550e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.994664e-01 0.000 0 0
Digestion R-HSA-8935690 9.995163e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.995888e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.996068e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.996068e-01 0.000 0 0
Regulation of beta-cell development R-HSA-186712 9.996621e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.997002e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.997006e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.997172e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.997297e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.997340e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.997340e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.997340e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997790e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.997799e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.997905e-01 0.000 0 0
Protein localization R-HSA-9609507 9.998134e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.998141e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.998351e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998686e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.998702e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998811e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.998823e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998848e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.999093e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999093e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999147e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.999195e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999195e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999322e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.999322e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999365e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999367e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999438e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999485e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999501e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999597e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.999652e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999691e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999721e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999747e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999757e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999842e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999847e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999857e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999862e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999882e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999886e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999905e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999907e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999927e-01 0.000 0 0
Disease R-HSA-1643685 9.999957e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999958e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999959e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999974e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.999978e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999983e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999983e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999986e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999992e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999993e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999995e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999997e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999997e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999998e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999998e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999998e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999999e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.155853e-12 11.937 0 0
Cellular response to heat stress R-HSA-3371556 7.356671e-12 11.133 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.622358e-10 9.790 0 0
Cell Cycle, Mitotic R-HSA-69278 5.758778e-10 9.240 0 0
HSF1-dependent transactivation R-HSA-3371571 7.959327e-10 9.099 0 0
Attenuation phase R-HSA-3371568 8.434019e-10 9.074 0 0
Cellular responses to stress R-HSA-2262752 2.608639e-09 8.584 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.997151e-09 8.222 0 0
Cellular responses to stimuli R-HSA-8953897 6.242037e-09 8.205 0 0
Mitotic Prophase R-HSA-68875 1.748037e-08 7.757 0 0
Apoptotic execution phase R-HSA-75153 4.945113e-08 7.306 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.115689e-08 7.291 0 0
Cell Cycle Checkpoints R-HSA-69620 5.773094e-08 7.239 0 0
HSF1 activation R-HSA-3371511 9.160067e-08 7.038 0 0
M Phase R-HSA-68886 1.204658e-07 6.919 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.043288e-07 6.517 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.375004e-06 5.862 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.007928e-06 5.522 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.132594e-06 5.504 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.573812e-06 5.447 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.715260e-06 5.243 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.985695e-06 5.098 0 0
Nucleosome assembly R-HSA-774815 7.985695e-06 5.098 0 0
HDACs deacetylate histones R-HSA-3214815 8.113395e-06 5.091 0 0
ESR-mediated signaling R-HSA-8939211 8.882826e-06 5.051 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.754072e-06 5.058 0 0
Signal Transduction R-HSA-162582 8.591334e-06 5.066 1 0
G2/M Checkpoints R-HSA-69481 8.799723e-06 5.056 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.547065e-05 4.810 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.598411e-05 4.796 0 0
Meiotic synapsis R-HSA-1221632 1.659637e-05 4.780 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.955966e-05 4.709 0 0
Axon guidance R-HSA-422475 1.924800e-05 4.716 1 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.285017e-05 4.641 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.492453e-05 4.603 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.595567e-05 4.586 0 0
Membrane Trafficking R-HSA-199991 2.583036e-05 4.588 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.479795e-05 4.458 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.334521e-05 4.477 0 0
Nervous system development R-HSA-9675108 4.754811e-05 4.323 1 0
Apoptosis R-HSA-109581 4.687818e-05 4.329 0 0
Chromatin modifying enzymes R-HSA-3247509 4.975754e-05 4.303 0 0
Chromatin organization R-HSA-4839726 5.590106e-05 4.253 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.964558e-05 4.224 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.973897e-05 4.224 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 6.617864e-05 4.179 0 0
Cellular Senescence R-HSA-2559583 8.910269e-05 4.050 0 0
DNA Double Strand Break Response R-HSA-5693606 9.571519e-05 4.019 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.015230e-04 3.993 0 0
Meiosis R-HSA-1500620 1.084348e-04 3.965 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.065648e-04 3.972 0 0
DNA methylation R-HSA-5334118 1.455680e-04 3.837 0 0
IRE1alpha activates chaperones R-HSA-381070 1.482701e-04 3.829 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.564945e-04 3.806 0 0
Interleukin-12 signaling R-HSA-9020591 1.677138e-04 3.775 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.938271e-04 3.713 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.901178e-04 3.721 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.901178e-04 3.721 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.060393e-04 3.686 0 0
Kinesins R-HSA-983189 2.060393e-04 3.686 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.060393e-04 3.686 0 0
HATs acetylate histones R-HSA-3214847 2.236984e-04 3.650 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.381083e-04 3.623 0 0
G alpha (12/13) signalling events R-HSA-416482 2.307565e-04 3.637 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.672360e-04 3.573 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.657873e-04 3.575 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.672360e-04 3.573 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.672360e-04 3.573 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.698436e-04 3.569 0 0
Packaging Of Telomere Ends R-HSA-171306 3.111869e-04 3.507 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.049108e-04 3.516 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.111869e-04 3.507 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.172432e-04 3.499 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.211140e-04 3.493 0 0
Signaling by ALK in cancer R-HSA-9700206 3.211140e-04 3.493 0 0
Homology Directed Repair R-HSA-5693538 3.305369e-04 3.481 0 0
Semaphorin interactions R-HSA-373755 3.481141e-04 3.458 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.608748e-04 3.443 0 0
Cell-Cell communication R-HSA-1500931 3.931603e-04 3.405 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.037546e-04 3.394 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 4.105547e-04 3.387 0 0
Interleukin-12 family signaling R-HSA-447115 4.157474e-04 3.381 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.668217e-04 3.331 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.978356e-04 3.303 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.089412e-04 3.293 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.798223e-04 3.237 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.234470e-04 3.205 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.016059e-04 3.221 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 5.976444e-04 3.224 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.378378e-04 3.195 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.629211e-04 3.179 0 0
Activation of BH3-only proteins R-HSA-114452 6.629211e-04 3.179 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.875102e-04 3.163 0 0
Gene Silencing by RNA R-HSA-211000 7.045179e-04 3.152 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.331141e-04 3.135 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 7.390936e-04 3.131 0 0
Amplification of signal from the kinetochores R-HSA-141424 7.390936e-04 3.131 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.472911e-04 3.127 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.508954e-04 3.124 0 0
Reproduction R-HSA-1474165 7.620862e-04 3.118 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.368589e-04 3.077 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.368589e-04 3.077 0 0
Meiotic recombination R-HSA-912446 8.554897e-04 3.068 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.936719e-04 3.049 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.710343e-04 3.060 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.904716e-04 3.050 0 0
ChREBP activates metabolic gene expression R-HSA-163765 9.211731e-04 3.036 0 0
Nuclear Envelope Breakdown R-HSA-2980766 8.863250e-04 3.052 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.314681e-04 3.031 0 0
Programmed Cell Death R-HSA-5357801 9.898467e-04 3.004 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.978871e-04 3.001 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.062116e-03 2.974 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.062308e-03 2.974 0 0
Influenza Infection R-HSA-168255 1.107322e-03 2.956 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.196801e-03 2.922 0 0
Cleavage of the damaged purine R-HSA-110331 1.196801e-03 2.922 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.210621e-03 2.917 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.210621e-03 2.917 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.217091e-03 2.915 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.299931e-03 2.886 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.299931e-03 2.886 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.410965e-03 2.850 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.365959e-03 2.865 0 0
RNA Polymerase I Transcription R-HSA-73864 1.348249e-03 2.870 0 0
Depurination R-HSA-73927 1.456046e-03 2.837 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.456046e-03 2.837 0 0
Defective pyroptosis R-HSA-9710421 1.563042e-03 2.806 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.592526e-03 2.798 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.600957e-03 2.796 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.600957e-03 2.796 0 0
Signaling by VEGF R-HSA-194138 1.642741e-03 2.784 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.694871e-03 2.771 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.917947e-03 2.717 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.922150e-03 2.716 0 0
NRAGE signals death through JNK R-HSA-193648 1.933023e-03 2.714 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.954929e-03 2.709 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.112854e-03 2.675 0 0
Mitotic Prometaphase R-HSA-68877 1.953611e-03 2.709 0 0
Nuclear import of Rev protein R-HSA-180746 1.957132e-03 2.708 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.115154e-03 2.675 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.115154e-03 2.675 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.277186e-03 2.643 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.369024e-03 2.625 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.375744e-03 2.624 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.526906e-03 2.597 0 0
Deubiquitination R-HSA-5688426 2.665150e-03 2.574 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.796526e-03 2.553 0 0
mRNA Splicing R-HSA-72172 2.804891e-03 2.552 0 0
RET signaling R-HSA-8853659 2.864603e-03 2.543 0 0
Signaling by Hippo R-HSA-2028269 2.982038e-03 2.525 0 0
Signal attenuation R-HSA-74749 3.113073e-03 2.507 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.201810e-03 2.495 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.371844e-03 2.472 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.432030e-03 2.464 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.547655e-03 2.450 0 0
Depyrimidination R-HSA-73928 3.547655e-03 2.450 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.632249e-03 2.440 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.718335e-03 2.430 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.881788e-03 2.411 0 0
Regulation of TP53 Activity R-HSA-5633007 4.035472e-03 2.394 0 0
HCMV Early Events R-HSA-9609690 4.235545e-03 2.373 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.235545e-03 2.373 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.244771e-03 2.372 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.867489e-03 2.313 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.867489e-03 2.313 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.576807e-03 2.339 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.576807e-03 2.339 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.436752e-03 2.353 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.442825e-03 2.352 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.723237e-03 2.326 0 0
Cell junction organization R-HSA-446728 4.396948e-03 2.357 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.637328e-03 2.334 0 0
Diseases of programmed cell death R-HSA-9645723 5.090053e-03 2.293 0 0
Metabolism of RNA R-HSA-8953854 5.096914e-03 2.293 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.266989e-03 2.278 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.547801e-03 2.256 0 0
Signaling by WNT R-HSA-195721 5.771578e-03 2.239 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.296333e-03 2.201 0 0
Nephrin family interactions R-HSA-373753 6.296333e-03 2.201 0 0
Vesicle-mediated transport R-HSA-5653656 6.322943e-03 2.199 0 0
mRNA 3'-end processing R-HSA-72187 6.404410e-03 2.194 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.404410e-03 2.194 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.524363e-03 2.185 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.213450e-03 2.142 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.575411e-03 2.182 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.477959e-03 2.189 0 0
Ub-specific processing proteases R-HSA-5689880 6.730779e-03 2.172 0 0
FLT3 Signaling R-HSA-9607240 6.670242e-03 2.176 0 0
Signaling by ROBO receptors R-HSA-376176 6.878546e-03 2.163 1 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.586705e-03 2.181 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.178039e-03 2.144 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.670242e-03 2.176 0 0
Recycling pathway of L1 R-HSA-437239 7.601830e-03 2.119 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.771246e-03 2.110 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.082530e-03 2.092 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.291227e-03 2.081 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.370778e-03 2.077 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.401855e-03 2.076 0 0
DNA Repair R-HSA-73894 8.468624e-03 2.072 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.140305e-03 2.039 0 0
Post NMDA receptor activation events R-HSA-438064 9.289585e-03 2.032 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 9.470843e-03 2.024 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.471069e-03 2.024 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.558123e-03 2.020 0 0
HIV Life Cycle R-HSA-162587 9.727247e-03 2.012 0 0
tRNA processing in the nucleus R-HSA-6784531 1.013415e-02 1.994 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.019063e-02 1.992 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.078634e-02 1.967 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.092048e-02 1.962 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.143764e-02 1.942 0 0
Striated Muscle Contraction R-HSA-390522 1.256222e-02 1.901 0 0
Chromosome Maintenance R-HSA-73886 1.300963e-02 1.886 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.235296e-02 1.908 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.317669e-02 1.880 0 0
Adherens junctions interactions R-HSA-418990 1.171840e-02 1.931 0 0
Death Receptor Signaling R-HSA-73887 1.329967e-02 1.876 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.318664e-02 1.880 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.362340e-02 1.866 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.366052e-02 1.865 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.368370e-02 1.864 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.372905e-02 1.862 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.395355e-02 1.855 0 0
Signaling by Leptin R-HSA-2586552 1.395355e-02 1.855 0 0
Regulation of KIT signaling R-HSA-1433559 1.409067e-02 1.851 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.433226e-02 1.844 0 0
Neurexins and neuroligins R-HSA-6794361 1.465761e-02 1.834 0 0
Sensory processing of sound R-HSA-9659379 1.488333e-02 1.827 0 0
Metabolism of non-coding RNA R-HSA-194441 1.539229e-02 1.813 0 0
snRNP Assembly R-HSA-191859 1.539229e-02 1.813 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.555979e-02 1.808 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.555979e-02 1.808 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.555979e-02 1.808 0 0
Signaling by RAS mutants R-HSA-6802949 1.555979e-02 1.808 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.609454e-02 1.793 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.609454e-02 1.793 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.636722e-02 1.786 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.723957e-02 1.763 0 0
Erythropoietin activates STAT5 R-HSA-9027283 1.686530e-02 1.773 0 0
STAT5 Activation R-HSA-9645135 1.686530e-02 1.773 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.785120e-02 1.748 0 0
MAP2K and MAPK activation R-HSA-5674135 1.870443e-02 1.728 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.908109e-02 1.719 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.908109e-02 1.719 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.908109e-02 1.719 0 0
HCMV Infection R-HSA-9609646 1.907235e-02 1.720 0 0
FLT3 signaling in disease R-HSA-9682385 1.960589e-02 1.708 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.921378e-02 1.716 0 0
Interleukin-2 signaling R-HSA-9020558 1.855253e-02 1.732 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.960726e-02 1.708 0 0
Peptide chain elongation R-HSA-156902 1.976047e-02 1.704 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.993459e-02 1.700 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.993459e-02 1.700 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.993459e-02 1.700 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.993459e-02 1.700 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.993459e-02 1.700 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.993459e-02 1.700 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.023063e-02 1.694 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.065873e-02 1.685 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.128032e-02 1.672 0 0
Ca-dependent events R-HSA-111996 2.128032e-02 1.672 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.128032e-02 1.672 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.316923e-02 1.635 0 0
Base Excision Repair R-HSA-73884 2.353340e-02 1.628 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.377383e-02 1.624 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.400378e-02 1.620 0 0
Signaling by SCF-KIT R-HSA-1433557 2.410767e-02 1.618 0 0
Mitotic Anaphase R-HSA-68882 2.512085e-02 1.600 0 0
Separation of Sister Chromatids R-HSA-2467813 2.553769e-02 1.593 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.633803e-02 1.579 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.648771e-02 1.577 0 0
HCMV Late Events R-HSA-9610379 2.658642e-02 1.575 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.706245e-02 1.568 0 0
L1CAM interactions R-HSA-373760 2.708167e-02 1.567 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.756041e-02 1.560 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.832700e-02 1.548 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.003287e-02 1.522 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.003287e-02 1.522 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.050187e-02 1.516 0 0
Interleukin-15 signaling R-HSA-8983432 3.050187e-02 1.516 0 0
Signaling by LTK R-HSA-9842663 3.050187e-02 1.516 0 0
Muscle contraction R-HSA-397014 3.077317e-02 1.512 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.139506e-02 1.503 0 0
Formation of annular gap junctions R-HSA-196025 3.192668e-02 1.496 0 0
Signaling by Erythropoietin R-HSA-9006335 3.752107e-02 1.426 0 0
Late endosomal microautophagy R-HSA-9615710 3.752107e-02 1.426 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.582503e-02 1.446 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 3.794407e-02 1.421 0 0
Protein ubiquitination R-HSA-8852135 3.780366e-02 1.422 0 0
mTORC1-mediated signalling R-HSA-166208 3.343642e-02 1.476 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.192668e-02 1.496 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.509569e-02 1.455 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.192668e-02 1.496 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.794407e-02 1.421 0 0
Specification of primordial germ cells R-HSA-9827857 3.310181e-02 1.480 0 0
Glycolysis R-HSA-70171 3.435463e-02 1.464 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.846051e-02 1.415 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.863287e-02 1.413 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.979812e-02 1.400 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.012760e-02 1.397 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.050852e-02 1.392 0 0
IRS activation R-HSA-74713 4.050852e-02 1.392 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.050852e-02 1.392 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.087246e-02 1.389 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.166640e-02 1.380 0 0
Gap junction degradation R-HSA-190873 4.167011e-02 1.380 0 0
ALK mutants bind TKIs R-HSA-9700645 4.167011e-02 1.380 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.167011e-02 1.380 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.167011e-02 1.380 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 4.183046e-02 1.379 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.183046e-02 1.379 0 0
Interleukin-37 signaling R-HSA-9008059 4.297306e-02 1.367 0 0
Cell-cell junction organization R-HSA-421270 4.324356e-02 1.364 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.332003e-02 1.363 0 0
MHC class II antigen presentation R-HSA-2132295 4.355909e-02 1.361 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.529305e-02 1.344 0 0
Calmodulin induced events R-HSA-111933 4.529305e-02 1.344 0 0
CaM pathway R-HSA-111997 4.529305e-02 1.344 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.541088e-02 1.343 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.541088e-02 1.343 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.584453e-02 1.339 0 0
MTOR signalling R-HSA-165159 4.653405e-02 1.332 0 0
Rap1 signalling R-HSA-392517 4.690642e-02 1.329 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.690642e-02 1.329 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.692715e-02 1.329 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.923186e-02 1.308 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.993930e-02 1.302 0 0
Inositol phosphate metabolism R-HSA-1483249 5.043257e-02 1.297 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.599522e-02 1.252 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.599522e-02 1.252 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.291166e-02 1.276 0 0
DCC mediated attractive signaling R-HSA-418885 5.589927e-02 1.253 0 0
Erythropoietin activates RAS R-HSA-9027284 5.589927e-02 1.253 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.589927e-02 1.253 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.496618e-02 1.260 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.538423e-02 1.257 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.334128e-02 1.198 0 0
PKR-mediated signaling R-HSA-9833482 5.669500e-02 1.246 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.589927e-02 1.253 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.088382e-02 1.293 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.291166e-02 1.276 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.159026e-02 1.210 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.669500e-02 1.246 0 0
Selective autophagy R-HSA-9663891 6.334128e-02 1.198 0 0
Autophagy R-HSA-9612973 6.097525e-02 1.215 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.291166e-02 1.276 0 0
Formation of the anterior neural plate R-HSA-9823739 5.589927e-02 1.253 0 0
MAPK family signaling cascades R-HSA-5683057 5.463561e-02 1.263 0 0
Signaling by NOTCH R-HSA-157118 5.441042e-02 1.264 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.236380e-02 1.205 0 0
HIV Infection R-HSA-162906 6.270744e-02 1.203 0 0
Ion transport by P-type ATPases R-HSA-936837 5.074398e-02 1.295 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.291166e-02 1.276 0 0
G2/M Transition R-HSA-69275 5.829786e-02 1.234 0 0
Amyloid fiber formation R-HSA-977225 6.113318e-02 1.214 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.337725e-02 1.198 0 0
DAG and IP3 signaling R-HSA-1489509 6.338281e-02 1.198 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.414880e-02 1.193 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.434042e-02 1.192 0 0
Signaling by ERBB2 R-HSA-1227986 6.706224e-02 1.174 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.798682e-02 1.168 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.798682e-02 1.168 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.940002e-02 1.159 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.940002e-02 1.159 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.940002e-02 1.159 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.940002e-02 1.159 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.940002e-02 1.159 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.940002e-02 1.159 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.940002e-02 1.159 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.940002e-02 1.159 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.940002e-02 1.159 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.940002e-02 1.159 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.940002e-02 1.159 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.940002e-02 1.159 0 0
Aggrephagy R-HSA-9646399 7.029316e-02 1.153 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.087699e-02 1.149 0 0
PLC beta mediated events R-HSA-112043 7.285872e-02 1.138 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 7.386672e-02 1.132 0 0
Nef and signal transduction R-HSA-164944 7.386672e-02 1.132 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.386672e-02 1.132 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.560170e-02 1.121 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.583844e-02 1.120 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.771274e-02 1.110 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.790141e-02 1.108 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.790141e-02 1.108 0 0
Disorders of Developmental Biology R-HSA-9675151 7.798518e-02 1.108 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 7.798518e-02 1.108 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.798518e-02 1.108 0 0
DNA Replication R-HSA-69306 7.855009e-02 1.105 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.979869e-02 1.098 0 0
Signaling by AXIN mutants R-HSA-4839735 7.979869e-02 1.098 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.979869e-02 1.098 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 7.979869e-02 1.098 0 0
Gene expression (Transcription) R-HSA-74160 8.135820e-02 1.090 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.187102e-02 1.087 0 0
Notch-HLH transcription pathway R-HSA-350054 8.386142e-02 1.076 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.016435e-01 0.993 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.016435e-01 0.993 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.016435e-01 0.993 0 0
Axonal growth stimulation R-HSA-209563 1.012650e-01 0.995 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.012650e-01 0.995 0 0
MET interacts with TNS proteins R-HSA-8875513 1.012650e-01 0.995 0 0
MET activates PTPN11 R-HSA-8865999 1.012650e-01 0.995 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 9.392397e-02 1.027 0 0
SOS-mediated signalling R-HSA-112412 9.392397e-02 1.027 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 9.392397e-02 1.027 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 9.534335e-02 1.021 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 9.534335e-02 1.021 0 0
Disorders of Nervous System Development R-HSA-9697154 9.534335e-02 1.021 0 0
Pervasive developmental disorders R-HSA-9005895 9.534335e-02 1.021 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 9.534335e-02 1.021 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 9.534335e-02 1.021 0 0
Scavenging by Class F Receptors R-HSA-3000484 9.534335e-02 1.021 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 9.534335e-02 1.021 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 9.534335e-02 1.021 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 9.534335e-02 1.021 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 9.534335e-02 1.021 0 0
Frs2-mediated activation R-HSA-170968 1.121911e-01 0.950 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 9.054725e-02 1.043 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 9.054725e-02 1.043 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.505095e-02 1.022 0 0
Thromboxane signalling through TP receptor R-HSA-428930 1.069969e-01 0.971 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.624121e-02 1.017 0 0
Activation of the pre-replicative complex R-HSA-68962 9.624121e-02 1.017 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.624121e-02 1.017 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.878090e-02 1.005 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.060922e-01 0.974 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.040851e-01 0.983 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.051622e-01 0.978 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.129923e-02 1.040 0 0
Repression of WNT target genes R-HSA-4641265 9.534335e-02 1.021 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.062528e-01 0.974 0 0
EPH-Ephrin signaling R-HSA-2682334 8.839363e-02 1.054 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.012650e-01 0.995 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.604238e-02 1.065 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.026217e-01 0.989 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.069969e-01 0.971 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.103450e-02 1.041 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.497489e-02 1.022 0 0
Co-inhibition by PD-1 R-HSA-389948 1.080387e-01 0.966 0 0
Ca2+ pathway R-HSA-4086398 1.017812e-01 0.992 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.714930e-02 1.013 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.040851e-01 0.983 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 9.392397e-02 1.027 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 9.392397e-02 1.027 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.069060e-01 0.971 0 0
Growth hormone receptor signaling R-HSA-982772 9.505095e-02 1.022 0 0
G1/S-Specific Transcription R-HSA-69205 9.555191e-02 1.020 0 0
Neurodegenerative Diseases R-HSA-8863678 1.069969e-01 0.971 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.069969e-01 0.971 0 0
Viral Infection Pathways R-HSA-9824446 1.054294e-01 0.977 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.121911e-01 0.950 0 0
Eukaryotic Translation Termination R-HSA-72764 1.124404e-01 0.949 0 0
Host Interactions of HIV factors R-HSA-162909 1.125301e-01 0.949 0 0
Developmental Biology R-HSA-1266738 1.125972e-01 0.948 1 0
G-protein mediated events R-HSA-112040 1.142444e-01 0.942 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.159385e-01 0.936 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.159385e-01 0.936 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.159385e-01 0.936 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.159385e-01 0.936 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.185596e-01 0.926 0 0
The NLRP3 inflammasome R-HSA-844456 1.185596e-01 0.926 0 0
Glucose metabolism R-HSA-70326 1.187494e-01 0.925 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.190122e-01 0.924 0 0
Interleukin-7 signaling R-HSA-1266695 1.196771e-01 0.922 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.196771e-01 0.922 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.196771e-01 0.922 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.198062e-01 0.922 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.198062e-01 0.922 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.198062e-01 0.922 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.198062e-01 0.922 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.198062e-01 0.922 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.212810e-01 0.916 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.255184e-01 0.901 0 0
Telomere Maintenance R-HSA-157579 1.258064e-01 0.900 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.258064e-01 0.900 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.259147e-01 0.900 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.300335e-01 0.886 0 0
G-protein beta:gamma signalling R-HSA-397795 1.300335e-01 0.886 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.300335e-01 0.886 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.300335e-01 0.886 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.300335e-01 0.886 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.300335e-01 0.886 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.300335e-01 0.886 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.318544e-01 0.880 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.330646e-01 0.876 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.330646e-01 0.876 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.330646e-01 0.876 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.339237e-01 0.873 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.339237e-01 0.873 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.339237e-01 0.873 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.339237e-01 0.873 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.339237e-01 0.873 0 0
Translation initiation complex formation R-HSA-72649 1.350335e-01 0.870 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.362684e-01 0.866 0 0
Regulation of gap junction activity R-HSA-191650 1.362684e-01 0.866 0 0
Interleukin-2 family signaling R-HSA-451927 1.370341e-01 0.863 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.394264e-01 0.856 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.929610e-01 0.715 0 0
TWIK-related spinal cord K+ channel (TRESK) R-HSA-1299344 1.929610e-01 0.715 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.929610e-01 0.715 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.929610e-01 0.715 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.929610e-01 0.715 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.929610e-01 0.715 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.929610e-01 0.715 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.734438e-01 0.761 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.396651e-01 0.855 0 0
Lipophagy R-HSA-9613354 1.396651e-01 0.855 0 0
PI3K/AKT activation R-HSA-198203 1.648517e-01 0.783 0 0
2-LTR circle formation R-HSA-164843 1.648517e-01 0.783 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.912467e-01 0.718 0 0
Signaling by APC mutants R-HSA-4839744 1.912467e-01 0.718 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.912467e-01 0.718 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.912467e-01 0.718 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.912467e-01 0.718 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.494204e-01 0.826 0 0
Phase 4 - resting membrane potential R-HSA-5576886 1.695905e-01 0.771 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.695905e-01 0.771 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.501237e-01 0.824 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.501237e-01 0.824 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.906461e-01 0.720 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.671001e-01 0.777 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.671001e-01 0.777 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.771339e-01 0.752 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.771339e-01 0.752 0 0
RAF activation R-HSA-5673000 1.554326e-01 0.808 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.929953e-01 0.714 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.551656e-01 0.809 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.469171e-01 0.833 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.469171e-01 0.833 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.999638e-01 0.699 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.769269e-01 0.752 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.667456e-01 0.778 0 0
Centrosome maturation R-HSA-380287 1.865377e-01 0.729 0 0
Viral mRNA Translation R-HSA-192823 1.711187e-01 0.767 0 0
Neutrophil degranulation R-HSA-6798695 1.857298e-01 0.731 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.486296e-01 0.828 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 1.906461e-01 0.720 0 0
Protein folding R-HSA-391251 1.404204e-01 0.853 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.765072e-01 0.753 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.695905e-01 0.771 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.471277e-01 0.832 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.929953e-01 0.714 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.424601e-01 0.846 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.728397e-01 0.762 0 0
Formation of the posterior neural plate R-HSA-9832991 1.912467e-01 0.718 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.766985e-01 0.753 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.847889e-01 0.733 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.695905e-01 0.771 0 0
GPER1 signaling R-HSA-9634597 1.526464e-01 0.816 0 0
Signaling by EGFR R-HSA-177929 1.551656e-01 0.809 0 0
Prolonged ERK activation events R-HSA-169893 1.695905e-01 0.771 0 0
Signal amplification R-HSA-392518 1.554326e-01 0.808 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.771339e-01 0.752 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.929953e-01 0.714 0 0
Trafficking of AMPA receptors R-HSA-399719 2.093700e-01 0.679 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.551678e-01 0.809 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.554326e-01 0.808 0 0
Cellular response to starvation R-HSA-9711097 1.422882e-01 0.847 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.606843e-01 0.794 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.025018e-01 0.694 0 0
Signalling to ERKs R-HSA-187687 1.689252e-01 0.772 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.715946e-01 0.765 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.637341e-01 0.786 0 0
Signaling by FGFR4 R-HSA-5654743 1.860924e-01 0.730 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.572613e-01 0.803 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.994023e-01 0.700 0 0
G1/S Transition R-HSA-69206 1.800195e-01 0.745 0 0
Protein methylation R-HSA-8876725 1.494204e-01 0.826 0 0
Signaling by MET R-HSA-6806834 1.573192e-01 0.803 0 0
Macroautophagy R-HSA-1632852 1.890308e-01 0.723 0 0
Signaling by NOTCH1 R-HSA-1980143 1.968276e-01 0.706 0 0
RNA Polymerase II Transcription R-HSA-73857 2.014776e-01 0.696 0 0
Interferon Signaling R-HSA-913531 1.693551e-01 0.771 0 0
Inhibition of PKR R-HSA-169131 1.929610e-01 0.715 0 0
Unwinding of DNA R-HSA-176974 1.396651e-01 0.855 0 0
Bicarbonate transporters R-HSA-425381 1.912467e-01 0.718 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.494204e-01 0.826 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.695905e-01 0.771 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.671001e-01 0.777 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.671001e-01 0.777 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.618306e-01 0.791 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.580201e-01 0.801 0 0
Opioid Signalling R-HSA-111885 1.793985e-01 0.746 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.501237e-01 0.824 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.618306e-01 0.791 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.657627e-01 0.781 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.396651e-01 0.855 0 0
Suppression of apoptosis R-HSA-9635465 1.912467e-01 0.718 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.471277e-01 0.832 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.929953e-01 0.714 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.459409e-01 0.836 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.564282e-01 0.806 0 0
Signaling by KIT in disease R-HSA-9669938 1.847889e-01 0.733 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.734438e-01 0.761 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.396651e-01 0.855 0 0
Tandem pore domain potassium channels R-HSA-1296346 1.648517e-01 0.783 0 0
Downstream signal transduction R-HSA-186763 2.093700e-01 0.679 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.606843e-01 0.794 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.471277e-01 0.832 0 0
PECAM1 interactions R-HSA-210990 1.912467e-01 0.718 0 0
Selenocysteine synthesis R-HSA-2408557 1.551678e-01 0.809 0 0
NrCAM interactions R-HSA-447038 1.734438e-01 0.761 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.671001e-01 0.777 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.471277e-01 0.832 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.002838e-01 0.698 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.734438e-01 0.761 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.119887e-01 0.674 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.119887e-01 0.674 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.119887e-01 0.674 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.124694e-01 0.673 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.126629e-01 0.672 0 0
Smooth Muscle Contraction R-HSA-445355 2.126629e-01 0.672 0 0
Signaling by FGFR3 R-HSA-5654741 2.130844e-01 0.671 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.186054e-01 0.660 0 0
Integration of provirus R-HSA-162592 2.186054e-01 0.660 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.186054e-01 0.660 0 0
Activation of RAC1 R-HSA-428540 2.186054e-01 0.660 1 1
Mitotic Telophase/Cytokinesis R-HSA-68884 2.186054e-01 0.660 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.186054e-01 0.660 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.220313e-01 0.654 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.220313e-01 0.654 0 0
Heme signaling R-HSA-9707616 2.235561e-01 0.651 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.255276e-01 0.647 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.262110e-01 0.645 0 0
Signaling by WNT in cancer R-HSA-4791275 2.262110e-01 0.645 0 0
Diseases of DNA repair R-HSA-9675135 2.271134e-01 0.644 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.289608e-01 0.640 0 0
GAB1 signalosome R-HSA-180292 2.349419e-01 0.629 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.349419e-01 0.629 0 0
Platelet sensitization by LDL R-HSA-432142 2.349419e-01 0.629 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.349419e-01 0.629 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.349419e-01 0.629 0 0
Polo-like kinase mediated events R-HSA-156711 2.349419e-01 0.629 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.349419e-01 0.629 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.359725e-01 0.627 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 2.750010e-01 0.561 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.750010e-01 0.561 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.750010e-01 0.561 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.750010e-01 0.561 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.750010e-01 0.561 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.750010e-01 0.561 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.750010e-01 0.561 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.750010e-01 0.561 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 2.750010e-01 0.561 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.750010e-01 0.561 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.487054e-01 0.458 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.487054e-01 0.458 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.487054e-01 0.458 0 0
Defective ABCD1 causes ALD R-HSA-5684045 3.487054e-01 0.458 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.487054e-01 0.458 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.487054e-01 0.458 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.512412e-01 0.600 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 2.512412e-01 0.600 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.906595e-01 0.537 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.906595e-01 0.537 0 0
Netrin mediated repulsion signals R-HSA-418886 2.906595e-01 0.537 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.906595e-01 0.537 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.906595e-01 0.537 0 0
Disinhibition of SNARE formation R-HSA-114516 2.906595e-01 0.537 0 0
Recycling of eIF2:GDP R-HSA-72731 2.906595e-01 0.537 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.149209e-01 0.382 0 0
FasL/ CD95L signaling R-HSA-75157 4.149209e-01 0.382 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.149209e-01 0.382 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 4.149209e-01 0.382 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 4.149209e-01 0.382 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.149209e-01 0.382 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.149209e-01 0.382 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.149209e-01 0.382 0 0
Classical Kir channels R-HSA-1296053 4.149209e-01 0.382 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 4.149209e-01 0.382 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.149209e-01 0.382 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.149209e-01 0.382 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.466935e-01 0.608 0 0
Type I hemidesmosome assembly R-HSA-446107 3.298046e-01 0.482 0 0
RSK activation R-HSA-444257 3.298046e-01 0.482 0 0
phospho-PLA2 pathway R-HSA-111995 3.298046e-01 0.482 0 0
MET receptor recycling R-HSA-8875656 3.298046e-01 0.482 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.752907e-01 0.560 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.752907e-01 0.560 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.752907e-01 0.560 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.041927e-01 0.517 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.683250e-01 0.434 0 0
WNT mediated activation of DVL R-HSA-201688 3.683250e-01 0.434 0 0
MAPK1 (ERK2) activation R-HSA-112411 3.683250e-01 0.434 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 3.683250e-01 0.434 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.744079e-01 0.324 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.744079e-01 0.324 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.744079e-01 0.324 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.744079e-01 0.324 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.744079e-01 0.324 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.744079e-01 0.324 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.744079e-01 0.324 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.414434e-01 0.617 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.332118e-01 0.477 0 0
Basigin interactions R-HSA-210991 3.050910e-01 0.516 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.059432e-01 0.392 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.059432e-01 0.392 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.059432e-01 0.392 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.059432e-01 0.392 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.814888e-01 0.551 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.814888e-01 0.551 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.610980e-01 0.583 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.610980e-01 0.583 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.621784e-01 0.441 0 0
Phosphorylation of the APC/C R-HSA-176412 3.621784e-01 0.441 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.019785e-01 0.520 0 0
HIV elongation arrest and recovery R-HSA-167287 3.019785e-01 0.520 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.019785e-01 0.520 0 0
FGFR2 alternative splicing R-HSA-6803529 3.530326e-01 0.452 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.424449e-01 0.354 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.770526e-01 0.424 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.193634e-01 0.377 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.718305e-01 0.430 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.473296e-01 0.349 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.150239e-01 0.502 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.596295e-01 0.444 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.596295e-01 0.444 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.247474e-01 0.372 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.247474e-01 0.372 0 0
G protein gated Potassium channels R-HSA-1296059 4.247474e-01 0.372 0 0
Integrin signaling R-HSA-354192 4.063670e-01 0.391 0 0
HIV Transcription Elongation R-HSA-167169 3.906628e-01 0.408 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.906628e-01 0.408 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.906628e-01 0.408 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.329577e-01 0.478 0 0
Signaling by NOTCH2 R-HSA-1980145 4.478741e-01 0.349 0 0
Dual Incision in GG-NER R-HSA-5696400 4.478741e-01 0.349 0 0
Cristae formation R-HSA-8949613 4.714706e-01 0.327 0 0
Transcription of the HIV genome R-HSA-167172 4.278796e-01 0.369 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.805046e-01 0.552 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.612866e-01 0.583 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.530280e-01 0.452 0 0
Formation of definitive endoderm R-HSA-9823730 2.813662e-01 0.551 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.813662e-01 0.551 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.193634e-01 0.377 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.995279e-01 0.398 0 0
Ribosome-associated quality control R-HSA-9948299 3.986546e-01 0.399 0 0
Co-stimulation by CD28 R-HSA-389356 2.561055e-01 0.592 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.691675e-01 0.570 0 0
HDMs demethylate histones R-HSA-3214842 2.414434e-01 0.617 0 0
TGFBR3 expression R-HSA-9839394 2.414434e-01 0.617 0 0
PCP/CE pathway R-HSA-4086400 3.198871e-01 0.495 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.714706e-01 0.327 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.287818e-01 0.483 0 0
Myogenesis R-HSA-525793 2.612866e-01 0.583 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.482653e-01 0.348 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.041927e-01 0.517 0 0
Josephin domain DUBs R-HSA-5689877 4.059432e-01 0.392 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.909405e-01 0.408 0 0
TCR signaling R-HSA-202403 4.354044e-01 0.361 0 0
Generation of second messenger molecules R-HSA-202433 2.431415e-01 0.614 0 0
MET activates RAS signaling R-HSA-8851805 2.466935e-01 0.608 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.041927e-01 0.517 0 0
Insulin receptor signalling cascade R-HSA-74751 2.486363e-01 0.604 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 2.972606e-01 0.527 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.814888e-01 0.551 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.621784e-01 0.441 0 0
Killing mechanisms R-HSA-9664420 3.621784e-01 0.441 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.790448e-01 0.554 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.009849e-01 0.397 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.226857e-01 0.491 0 0
Mismatch Repair R-HSA-5358508 4.473296e-01 0.349 0 0
Formation of axial mesoderm R-HSA-9796292 2.752907e-01 0.560 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.744079e-01 0.324 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.332118e-01 0.477 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.972606e-01 0.527 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.909405e-01 0.408 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 3.435424e-01 0.464 0 0
PKA activation R-HSA-163615 4.473296e-01 0.349 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.424918e-01 0.465 0 0
Nuclear RNA decay R-HSA-9930044 4.063670e-01 0.391 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.466935e-01 0.608 0 0
Long-term potentiation R-HSA-9620244 2.414434e-01 0.617 0 0
Gap junction trafficking and regulation R-HSA-157858 2.710132e-01 0.567 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.879305e-01 0.541 0 0
IGF1R signaling cascade R-HSA-2428924 2.486363e-01 0.604 0 0
Regulation of CDH1 Function R-HSA-9764561 2.663482e-01 0.575 0 0
Oncogene Induced Senescence R-HSA-2559585 2.972606e-01 0.527 0 0
Netrin-1 signaling R-HSA-373752 3.254584e-01 0.488 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.752907e-01 0.560 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.579459e-01 0.588 0 0
Calcineurin activates NFAT R-HSA-2025928 3.683250e-01 0.434 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.332118e-01 0.477 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.059432e-01 0.392 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.909405e-01 0.408 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.193634e-01 0.377 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.576935e-01 0.589 0 0
Signaling by FGFR2 R-HSA-5654738 2.403725e-01 0.619 0 0
Gap junction trafficking R-HSA-190828 3.254584e-01 0.488 0 0
Signaling by Insulin receptor R-HSA-74752 3.036106e-01 0.518 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.226857e-01 0.491 0 0
PTEN Regulation R-HSA-6807070 3.193279e-01 0.496 0 0
Ephrin signaling R-HSA-3928664 4.473296e-01 0.349 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.615295e-01 0.582 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.683250e-01 0.434 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.683250e-01 0.434 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.814888e-01 0.551 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.621784e-01 0.441 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.290137e-01 0.483 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.770526e-01 0.424 0 0
DNA strand elongation R-HSA-69190 3.854443e-01 0.414 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.014216e-01 0.521 0 0
S Phase R-HSA-69242 3.302665e-01 0.481 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.918506e-01 0.535 0 0
MET promotes cell motility R-HSA-8875878 3.530280e-01 0.452 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.247474e-01 0.372 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.063670e-01 0.391 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.009849e-01 0.397 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.311028e-01 0.365 0 0
Signaling by FGFR1 R-HSA-5654736 3.803700e-01 0.420 0 0
MAP kinase activation R-HSA-450294 4.601682e-01 0.337 0 0
GPVI-mediated activation cascade R-HSA-114604 3.156956e-01 0.501 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.094813e-01 0.388 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.750010e-01 0.561 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.750010e-01 0.561 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.750010e-01 0.561 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.487054e-01 0.458 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.298046e-01 0.482 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.752907e-01 0.560 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.752907e-01 0.560 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.744079e-01 0.324 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.059432e-01 0.392 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.790448e-01 0.554 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.414629e-01 0.617 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.909405e-01 0.408 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.424449e-01 0.354 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.530280e-01 0.452 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.009849e-01 0.397 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.473296e-01 0.349 0 0
PKA activation in glucagon signalling R-HSA-164378 4.473296e-01 0.349 0 0
Metalloprotease DUBs R-HSA-5689901 4.482653e-01 0.348 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.150040e-01 0.382 0 0
Generic Transcription Pathway R-HSA-212436 3.722934e-01 0.429 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.893544e-01 0.539 0 0
Signaling by TGFB family members R-HSA-9006936 4.466237e-01 0.350 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.755008e-01 0.425 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.041927e-01 0.517 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.591014e-01 0.587 0 0
Integration of energy metabolism R-HSA-163685 3.780725e-01 0.422 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.332118e-01 0.477 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.655628e-01 0.332 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.129705e-01 0.384 0 0
Signaling by FGFR in disease R-HSA-1226099 2.689670e-01 0.570 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.972606e-01 0.527 0 0
TBC/RABGAPs R-HSA-8854214 4.654468e-01 0.332 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.403725e-01 0.619 0 0
Hemostasis R-HSA-109582 2.434124e-01 0.614 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.725959e-01 0.326 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 3.041927e-01 0.517 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.683250e-01 0.434 0 0
Interleukin-21 signaling R-HSA-9020958 3.683250e-01 0.434 0 0
Signaling by NOTCH4 R-HSA-9013694 2.689670e-01 0.570 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.287818e-01 0.483 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.123647e-01 0.385 0 0
Cardiac conduction R-HSA-5576891 4.097512e-01 0.387 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.424918e-01 0.465 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 4.247474e-01 0.372 0 0
Signaling by NTRKs R-HSA-166520 3.302665e-01 0.481 0 0
Signaling by PTK6 R-HSA-8848021 3.530894e-01 0.452 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.530894e-01 0.452 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.453061e-01 0.610 0 0
Ion homeostasis R-HSA-5578775 3.803700e-01 0.420 0 0
Signaling by NOTCH3 R-HSA-9012852 3.644134e-01 0.438 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.770526e-01 0.424 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.679728e-01 0.434 0 0
RUNX2 regulates bone development R-HSA-8941326 3.156956e-01 0.501 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.750010e-01 0.561 0 0
DSCAM interactions R-HSA-376172 3.487054e-01 0.458 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.683250e-01 0.434 0 0
NADE modulates death signalling R-HSA-205025 4.744079e-01 0.324 0 0
Sensory perception of sour taste R-HSA-9729555 4.744079e-01 0.324 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.434701e-01 0.614 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.434701e-01 0.614 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.610980e-01 0.583 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.909405e-01 0.408 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.469119e-01 0.350 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.290137e-01 0.483 0 0
PI Metabolism R-HSA-1483255 4.368755e-01 0.360 0 0
Interleukin-9 signaling R-HSA-8985947 3.298046e-01 0.482 0 0
Signal regulatory protein family interactions R-HSA-391160 3.041927e-01 0.517 0 0
Signaling by Interleukins R-HSA-449147 2.559079e-01 0.592 0 0
DNA Damage Bypass R-HSA-73893 2.710132e-01 0.567 0 0
FOXO-mediated transcription R-HSA-9614085 3.999896e-01 0.398 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.298046e-01 0.482 0 0
Prolactin receptor signaling R-HSA-1170546 3.041927e-01 0.517 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.530326e-01 0.452 0 0
Tie2 Signaling R-HSA-210993 4.473296e-01 0.349 0 0
Ion channel transport R-HSA-983712 4.687219e-01 0.329 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.814599e-01 0.551 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.473296e-01 0.349 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.063670e-01 0.391 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.906595e-01 0.537 0 0
Dopamine receptors R-HSA-390651 4.744079e-01 0.324 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.744079e-01 0.324 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.744079e-01 0.324 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.059432e-01 0.392 0 0
Inflammasomes R-HSA-622312 3.019785e-01 0.520 0 0
Potential therapeutics for SARS R-HSA-9679191 3.492478e-01 0.457 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.940768e-01 0.404 0 0
Signaling by ALK R-HSA-201556 3.718305e-01 0.430 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.683250e-01 0.434 0 0
Interleukin-1 processing R-HSA-448706 3.683250e-01 0.434 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.424449e-01 0.354 0 0
Insulin processing R-HSA-264876 4.714706e-01 0.327 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.909405e-01 0.408 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.106226e-01 0.508 0 0
SARS-CoV Infections R-HSA-9679506 3.075726e-01 0.512 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.747377e-01 0.324 0 0
Regulation of signaling by CBL R-HSA-912631 4.747377e-01 0.324 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.747377e-01 0.324 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.747377e-01 0.324 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.747377e-01 0.324 0 0
Specification of the neural plate border R-HSA-9834899 4.747377e-01 0.324 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.747377e-01 0.324 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.759539e-01 0.322 0 0
Developmental Cell Lineages R-HSA-9734767 4.760600e-01 0.322 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 4.776682e-01 0.321 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 4.776682e-01 0.321 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.776682e-01 0.321 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.776682e-01 0.321 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.776682e-01 0.321 0 0
NF-kB is activated and signals survival R-HSA-209560 4.776682e-01 0.321 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.776682e-01 0.321 0 0
RMTs methylate histone arginines R-HSA-3214858 4.838137e-01 0.315 0 0
Selenoamino acid metabolism R-HSA-2408522 4.858110e-01 0.314 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.873527e-01 0.312 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.885968e-01 0.311 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.885968e-01 0.311 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.943024e-01 0.306 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.943024e-01 0.306 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.943024e-01 0.306 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.943024e-01 0.306 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.943024e-01 0.306 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.015012e-01 0.300 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.015012e-01 0.300 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 5.015012e-01 0.300 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.015012e-01 0.300 0 0
Signaling by NODAL R-HSA-1181150 5.015012e-01 0.300 0 0
Protein hydroxylation R-HSA-9629569 5.015012e-01 0.300 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.019797e-01 0.299 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.019797e-01 0.299 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.019797e-01 0.299 0 0
Signaling by FGFR R-HSA-190236 5.020035e-01 0.299 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.020043e-01 0.299 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.058783e-01 0.296 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.085530e-01 0.294 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.114924e-01 0.291 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.114958e-01 0.291 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.114958e-01 0.291 0 0
OAS antiviral response R-HSA-8983711 5.114958e-01 0.291 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.130499e-01 0.290 0 0
G alpha (z) signalling events R-HSA-418597 5.130499e-01 0.290 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.167064e-01 0.287 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.167064e-01 0.287 0 0
DARPP-32 events R-HSA-180024 5.167064e-01 0.287 0 0
Glucagon-type ligand receptors R-HSA-420092 5.167064e-01 0.287 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.199144e-01 0.284 0 0
Circadian clock R-HSA-9909396 5.200433e-01 0.284 0 0
Gastrulation R-HSA-9758941 5.223991e-01 0.282 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.264595e-01 0.279 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.275483e-01 0.278 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.275483e-01 0.278 0 0
G-protein activation R-HSA-202040 5.275483e-01 0.278 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.275483e-01 0.278 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.275483e-01 0.278 0 0
Signalling to RAS R-HSA-167044 5.275483e-01 0.278 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.275483e-01 0.278 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.278498e-01 0.277 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.278498e-01 0.277 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.278498e-01 0.277 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.278498e-01 0.277 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.278498e-01 0.277 0 0
Defective F9 activation R-HSA-9673221 5.278498e-01 0.277 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.278498e-01 0.277 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.278498e-01 0.277 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.278498e-01 0.277 0 0
Reelin signalling pathway R-HSA-8866376 5.278498e-01 0.277 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.278498e-01 0.277 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.278498e-01 0.277 0 0
Co-inhibition by BTLA R-HSA-9927353 5.278498e-01 0.277 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.278498e-01 0.277 0 0
Adaptive Immune System R-HSA-1280218 5.278681e-01 0.277 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.281876e-01 0.277 0 0
TNF signaling R-HSA-75893 5.294628e-01 0.276 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.309237e-01 0.275 0 0
DAP12 signaling R-HSA-2424491 5.386352e-01 0.269 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.386352e-01 0.269 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.386352e-01 0.269 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 5.386352e-01 0.269 0 0
Mitochondrial biogenesis R-HSA-1592230 5.403660e-01 0.267 0 0
Rab regulation of trafficking R-HSA-9007101 5.403660e-01 0.267 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.438475e-01 0.265 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.438475e-01 0.265 0 0
Processing of SMDT1 R-HSA-8949664 5.438475e-01 0.265 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.438475e-01 0.265 0 0
Maturation of nucleoprotein R-HSA-9683610 5.438475e-01 0.265 0 0
Interleukin-6 signaling R-HSA-1059683 5.438475e-01 0.265 0 0
IRS-mediated signalling R-HSA-112399 5.456569e-01 0.263 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.523504e-01 0.258 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 5.528200e-01 0.257 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.528200e-01 0.257 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.528200e-01 0.257 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 5.528200e-01 0.257 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.528200e-01 0.257 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.528200e-01 0.257 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 5.528200e-01 0.257 0 0
Assembly Of The HIV Virion R-HSA-175474 5.528200e-01 0.257 0 0
Platelet degranulation R-HSA-114608 5.572789e-01 0.254 0 0
EGFR downregulation R-HSA-182971 5.600477e-01 0.252 0 0
Cilium Assembly R-HSA-5617833 5.628050e-01 0.250 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.651232e-01 0.248 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.663599e-01 0.247 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.663599e-01 0.247 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.746737e-01 0.241 0 0
Removal of the Flap Intermediate R-HSA-69166 5.746737e-01 0.241 0 0
HDL assembly R-HSA-8963896 5.746737e-01 0.241 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.746737e-01 0.241 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.746737e-01 0.241 0 0
Zinc transporters R-HSA-435354 5.746737e-01 0.241 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.758606e-01 0.240 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.758606e-01 0.240 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.758606e-01 0.240 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.758606e-01 0.240 0 0
Signaling by MAPK mutants R-HSA-9652817 5.758606e-01 0.240 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.758606e-01 0.240 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.758606e-01 0.240 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.758606e-01 0.240 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.758606e-01 0.240 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 5.758606e-01 0.240 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.758606e-01 0.240 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.758606e-01 0.240 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.758606e-01 0.240 0 0
Threonine catabolism R-HSA-8849175 5.758606e-01 0.240 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.758606e-01 0.240 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.758606e-01 0.240 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.758606e-01 0.240 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.758606e-01 0.240 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 5.758606e-01 0.240 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.758606e-01 0.240 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.758606e-01 0.240 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.758606e-01 0.240 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.758606e-01 0.240 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.758606e-01 0.240 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.758606e-01 0.240 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.772693e-01 0.239 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.772693e-01 0.239 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 5.772693e-01 0.239 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.772693e-01 0.239 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.773095e-01 0.239 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.809088e-01 0.236 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.809088e-01 0.236 0 0
G0 and Early G1 R-HSA-1538133 5.809088e-01 0.236 0 0
PPARA activates gene expression R-HSA-1989781 5.820432e-01 0.235 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.848408e-01 0.233 0 0
PI3K Cascade R-HSA-109704 5.888139e-01 0.230 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.893805e-01 0.230 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.965592e-01 0.224 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.965592e-01 0.224 0 0
Interleukin-17 signaling R-HSA-448424 5.965592e-01 0.224 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.974764e-01 0.224 0 0
Neuronal System R-HSA-112316 5.978777e-01 0.223 0 0
Nucleotide Excision Repair R-HSA-5696398 5.992539e-01 0.222 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.008604e-01 0.221 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.008604e-01 0.221 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 6.008604e-01 0.221 0 0
Syndecan interactions R-HSA-3000170 6.008604e-01 0.221 0 0
Interleukin-20 family signaling R-HSA-8854691 6.008604e-01 0.221 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.011893e-01 0.221 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 6.012840e-01 0.221 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.028860e-01 0.220 0 0
HIV Transcription Initiation R-HSA-167161 6.028860e-01 0.220 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.028860e-01 0.220 0 0
Intra-Golgi traffic R-HSA-6811438 6.028860e-01 0.220 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.039500e-01 0.219 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.039500e-01 0.219 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.039500e-01 0.219 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.039500e-01 0.219 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.039500e-01 0.219 0 0
Transport and metabolism of PAPS R-HSA-174362 6.039500e-01 0.219 0 0
p75NTR signals via NF-kB R-HSA-193639 6.039500e-01 0.219 0 0
Signaling by Activin R-HSA-1502540 6.039500e-01 0.219 0 0
Biotin transport and metabolism R-HSA-196780 6.039500e-01 0.219 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.039500e-01 0.219 0 0
SLC transporter disorders R-HSA-5619102 6.049530e-01 0.218 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.052184e-01 0.218 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.067055e-01 0.217 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.078659e-01 0.216 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.135441e-01 0.212 0 0
Parasite infection R-HSA-9664407 6.136373e-01 0.212 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.136373e-01 0.212 0 0
Leishmania phagocytosis R-HSA-9664417 6.136373e-01 0.212 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.189919e-01 0.208 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.189919e-01 0.208 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.189919e-01 0.208 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.189919e-01 0.208 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.189919e-01 0.208 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.189919e-01 0.208 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.189919e-01 0.208 0 0
CREB phosphorylation R-HSA-199920 6.189919e-01 0.208 0 0
Signaling by LTK in cancer R-HSA-9842640 6.189919e-01 0.208 0 0
NADPH regeneration R-HSA-389542 6.189919e-01 0.208 0 0
Lipid particle organization R-HSA-8964572 6.189919e-01 0.208 0 0
HDL clearance R-HSA-8964011 6.189919e-01 0.208 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.193323e-01 0.208 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.193323e-01 0.208 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.193323e-01 0.208 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.208652e-01 0.207 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 6.208652e-01 0.207 0 0
Orc1 removal from chromatin R-HSA-68949 6.212588e-01 0.207 0 0
Synthesis of DNA R-HSA-69239 6.222006e-01 0.206 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.226959e-01 0.206 0 0
Signaling by PDGF R-HSA-186797 6.226959e-01 0.206 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.235673e-01 0.205 0 0
Deadenylation of mRNA R-HSA-429947 6.235673e-01 0.205 0 0
Regulation of BACH1 activity R-HSA-9708530 6.316730e-01 0.200 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.316730e-01 0.200 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.316730e-01 0.200 0 0
Negative regulation of FLT3 R-HSA-9706369 6.316730e-01 0.200 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.316730e-01 0.200 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.316730e-01 0.200 0 0
Virus Assembly and Release R-HSA-168268 6.316730e-01 0.200 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.375938e-01 0.195 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.399179e-01 0.194 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.399179e-01 0.194 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.399179e-01 0.194 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.399179e-01 0.194 0 0
Mitophagy R-HSA-5205647 6.399179e-01 0.194 0 0
Gap junction assembly R-HSA-190861 6.399179e-01 0.194 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.399179e-01 0.194 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.453726e-01 0.190 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.453726e-01 0.190 0 0
Signaling by ERBB4 R-HSA-1236394 6.514000e-01 0.186 0 0
Cyclin D associated events in G1 R-HSA-69231 6.542262e-01 0.184 0 0
G1 Phase R-HSA-69236 6.542262e-01 0.184 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.542262e-01 0.184 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.553518e-01 0.184 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.553518e-01 0.184 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.577394e-01 0.182 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.577394e-01 0.182 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.577394e-01 0.182 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.577394e-01 0.182 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.577394e-01 0.182 0 0
PTK6 Expression R-HSA-8849473 6.577394e-01 0.182 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.577394e-01 0.182 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.577394e-01 0.182 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.577394e-01 0.182 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.577394e-01 0.182 0 0
VLDL clearance R-HSA-8964046 6.577394e-01 0.182 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.577394e-01 0.182 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.577394e-01 0.182 0 0
Regulation of PTEN localization R-HSA-8948747 6.577394e-01 0.182 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.577394e-01 0.182 0 0
CHL1 interactions R-HSA-447041 6.577394e-01 0.182 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.578558e-01 0.182 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.578558e-01 0.182 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.578558e-01 0.182 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 6.578558e-01 0.182 0 0
Coenzyme A biosynthesis R-HSA-196783 6.578558e-01 0.182 0 0
Synthesis of PG R-HSA-1483148 6.578558e-01 0.182 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.578558e-01 0.182 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.583332e-01 0.182 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.662670e-01 0.176 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.662670e-01 0.176 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.662670e-01 0.176 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.703623e-01 0.174 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.759872e-01 0.170 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.761014e-01 0.170 0 0
RNA Polymerase III Transcription R-HSA-74158 6.761014e-01 0.170 0 0
rRNA processing R-HSA-72312 6.781874e-01 0.169 0 0
Parasitic Infection Pathways R-HSA-9824443 6.804858e-01 0.167 0 0
Leishmania infection R-HSA-9658195 6.804858e-01 0.167 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 6.815258e-01 0.167 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.825248e-01 0.166 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.825248e-01 0.166 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.825248e-01 0.166 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.825248e-01 0.166 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.859943e-01 0.164 0 0
Signaling by TGFBR3 R-HSA-9839373 6.859943e-01 0.164 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.859943e-01 0.164 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.859943e-01 0.164 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.862481e-01 0.164 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.862481e-01 0.164 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.862481e-01 0.164 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 6.862481e-01 0.164 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.925485e-01 0.160 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.925485e-01 0.160 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.925485e-01 0.160 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.925485e-01 0.160 0 0
Regulation by c-FLIP R-HSA-3371378 6.925485e-01 0.160 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 6.925485e-01 0.160 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.925485e-01 0.160 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.925485e-01 0.160 0 0
Dimerization of procaspase-8 R-HSA-69416 6.925485e-01 0.160 0 0
Alpha-defensins R-HSA-1462054 6.925485e-01 0.160 0 0
Sodium/Proton exchangers R-HSA-425986 6.925485e-01 0.160 0 0
Degradation of DVL R-HSA-4641258 6.932165e-01 0.159 0 0
Pyruvate metabolism R-HSA-70268 6.995704e-01 0.155 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.011164e-01 0.154 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.011164e-01 0.154 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.053196e-01 0.152 0 0
Insulin receptor recycling R-HSA-77387 7.053196e-01 0.152 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.057172e-01 0.151 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.057172e-01 0.151 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.057172e-01 0.151 0 0
Apoptotic factor-mediated response R-HSA-111471 7.057172e-01 0.151 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.057172e-01 0.151 0 0
Nephron development R-HSA-9831926 7.057172e-01 0.151 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.076759e-01 0.150 0 0
Dual incision in TC-NER R-HSA-6782135 7.092014e-01 0.149 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.096764e-01 0.149 0 0
Immune System R-HSA-168256 7.119136e-01 0.148 0 0
Metal ion SLC transporters R-HSA-425410 7.157257e-01 0.145 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.165767e-01 0.145 0 0
mRNA Capping R-HSA-72086 7.234902e-01 0.141 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.234902e-01 0.141 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.234902e-01 0.141 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.238192e-01 0.140 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.238192e-01 0.140 0 0
CASP8 activity is inhibited R-HSA-5218900 7.238192e-01 0.140 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.238192e-01 0.140 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.238192e-01 0.140 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.238192e-01 0.140 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.238192e-01 0.140 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.238192e-01 0.140 0 0
ARMS-mediated activation R-HSA-170984 7.238192e-01 0.140 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.238192e-01 0.140 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.238192e-01 0.140 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.238192e-01 0.140 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.238192e-01 0.140 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.238192e-01 0.140 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.238192e-01 0.140 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.254820e-01 0.139 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.274780e-01 0.138 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.274780e-01 0.138 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.274780e-01 0.138 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.274780e-01 0.138 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.274780e-01 0.138 0 0
Maturation of nucleoprotein R-HSA-9694631 7.274780e-01 0.138 0 0
Interleukin-1 family signaling R-HSA-446652 7.317179e-01 0.136 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.372457e-01 0.132 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.406373e-01 0.130 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.406373e-01 0.130 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.406373e-01 0.130 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.407734e-01 0.130 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.434035e-01 0.129 0 0
Azathioprine ADME R-HSA-9748787 7.434035e-01 0.129 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.466483e-01 0.127 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.475466e-01 0.126 0 0
Aquaporin-mediated transport R-HSA-445717 7.475466e-01 0.126 0 0
Negative regulation of MET activity R-HSA-6807004 7.478584e-01 0.126 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.478584e-01 0.126 0 0
Regulation of CDH11 function R-HSA-9762292 7.519110e-01 0.124 0 0
Binding and entry of HIV virion R-HSA-173107 7.519110e-01 0.124 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.519110e-01 0.124 0 0
DNA replication initiation R-HSA-68952 7.519110e-01 0.124 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.519110e-01 0.124 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.519110e-01 0.124 0 0
Pexophagy R-HSA-9664873 7.519110e-01 0.124 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.519110e-01 0.124 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.519110e-01 0.124 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.519110e-01 0.124 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.519110e-01 0.124 0 0
Interleukin-27 signaling R-HSA-9020956 7.519110e-01 0.124 0 0
Maturation of spike protein R-HSA-9683686 7.519110e-01 0.124 0 0
Formation of apoptosome R-HSA-111458 7.519110e-01 0.124 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 7.551488e-01 0.122 0 0
Budding and maturation of HIV virion R-HSA-162588 7.571862e-01 0.121 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.571862e-01 0.121 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.669142e-01 0.115 0 0
ERK/MAPK targets R-HSA-198753 7.669142e-01 0.115 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.669142e-01 0.115 0 0
Lagging Strand Synthesis R-HSA-69186 7.669142e-01 0.115 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.669142e-01 0.115 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.690253e-01 0.114 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.690420e-01 0.114 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.771469e-01 0.109 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.771469e-01 0.109 0 0
vRNP Assembly R-HSA-192905 7.771469e-01 0.109 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.771469e-01 0.109 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.771469e-01 0.109 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.771469e-01 0.109 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.771469e-01 0.109 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.771469e-01 0.109 0 0
Prostanoid ligand receptors R-HSA-391908 7.771469e-01 0.109 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.771469e-01 0.109 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.811084e-01 0.107 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.811084e-01 0.107 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.819647e-01 0.107 0 0
Activation of GABAB receptors R-HSA-991365 7.822775e-01 0.107 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 7.822775e-01 0.107 0 0
GABA B receptor activation R-HSA-977444 7.822775e-01 0.107 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.843196e-01 0.106 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.847039e-01 0.105 0 0
Ribavirin ADME R-HSA-9755088 7.847039e-01 0.105 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.872862e-01 0.104 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.874848e-01 0.104 0 0
Cardiogenesis R-HSA-9733709 7.874848e-01 0.104 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 7.874848e-01 0.104 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.907048e-01 0.102 0 0
Adipogenesis R-HSA-9843745 7.914708e-01 0.102 0 0
tRNA processing R-HSA-72306 7.966896e-01 0.099 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.998172e-01 0.097 0 0
ERKs are inactivated R-HSA-202670 7.998172e-01 0.097 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.998172e-01 0.097 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.998172e-01 0.097 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.998172e-01 0.097 0 0
Plasmalogen biosynthesis R-HSA-75896 7.998172e-01 0.097 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.998172e-01 0.097 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.998172e-01 0.097 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.998172e-01 0.097 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 7.998172e-01 0.097 0 0
Sodium/Calcium exchangers R-HSA-425561 7.998172e-01 0.097 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.012877e-01 0.096 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.012877e-01 0.096 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.012877e-01 0.096 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.012877e-01 0.096 0 0
LDL clearance R-HSA-8964038 8.012877e-01 0.096 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 8.012877e-01 0.096 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.014185e-01 0.096 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.014185e-01 0.096 0 0
DAP12 interactions R-HSA-2172127 8.069607e-01 0.093 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.078969e-01 0.093 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.078969e-01 0.093 0 0
Potassium Channels R-HSA-1296071 8.078969e-01 0.093 0 0
Transmission across Chemical Synapses R-HSA-112315 8.084084e-01 0.092 0 0
Platelet homeostasis R-HSA-418346 8.106305e-01 0.091 0 0
eNOS activation R-HSA-203615 8.145769e-01 0.089 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.167269e-01 0.088 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.167269e-01 0.088 0 0
Carnitine shuttle R-HSA-200425 8.167269e-01 0.088 0 0
Somitogenesis R-HSA-9824272 8.184208e-01 0.087 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.201824e-01 0.086 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.201824e-01 0.086 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.201824e-01 0.086 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.201824e-01 0.086 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.201824e-01 0.086 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.201824e-01 0.086 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.201824e-01 0.086 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.201824e-01 0.086 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.201824e-01 0.086 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.201824e-01 0.086 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.201824e-01 0.086 0 0
Polymerase switching R-HSA-69091 8.201824e-01 0.086 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.201824e-01 0.086 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.201824e-01 0.086 0 0
Leading Strand Synthesis R-HSA-69109 8.201824e-01 0.086 0 0
Regulation of IFNG signaling R-HSA-877312 8.201824e-01 0.086 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.201824e-01 0.086 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.201824e-01 0.086 0 0
Interleukin-35 Signalling R-HSA-8984722 8.201824e-01 0.086 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.201824e-01 0.086 0 0
Regulation of insulin secretion R-HSA-422356 8.240051e-01 0.084 0 0
Synthesis of PA R-HSA-1483166 8.245337e-01 0.084 0 0
Infectious disease R-HSA-5663205 8.253592e-01 0.083 0 0
PERK regulates gene expression R-HSA-381042 8.269878e-01 0.083 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.269878e-01 0.083 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.293147e-01 0.081 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.293147e-01 0.081 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.293147e-01 0.081 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.310827e-01 0.080 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.310827e-01 0.080 0 0
Interleukin-6 family signaling R-HSA-6783589 8.310827e-01 0.080 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.324471e-01 0.080 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.384770e-01 0.077 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.384770e-01 0.077 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.384770e-01 0.077 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.384770e-01 0.077 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.384770e-01 0.077 0 0
Hedgehog 'off' state R-HSA-5610787 8.390559e-01 0.076 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.396593e-01 0.076 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.417325e-01 0.075 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.417325e-01 0.075 0 0
Regulation of beta-cell development R-HSA-186712 8.434812e-01 0.074 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.444157e-01 0.073 0 0
Hyaluronan degradation R-HSA-2160916 8.444157e-01 0.073 0 0
NGF-stimulated transcription R-HSA-9031628 8.494724e-01 0.071 0 0
Interferon gamma signaling R-HSA-877300 8.502136e-01 0.070 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.544998e-01 0.068 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.549112e-01 0.068 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.549112e-01 0.068 0 0
Hydrolysis of LPC R-HSA-1483115 8.549112e-01 0.068 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.549112e-01 0.068 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.549112e-01 0.068 0 0
cGMP effects R-HSA-418457 8.549112e-01 0.068 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 8.549112e-01 0.068 0 0
Physiological factors R-HSA-5578768 8.549112e-01 0.068 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.549112e-01 0.068 0 0
Malate-aspartate shuttle R-HSA-9856872 8.549112e-01 0.068 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.549112e-01 0.068 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.549112e-01 0.068 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.549112e-01 0.068 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.565927e-01 0.067 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.567853e-01 0.067 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.567853e-01 0.067 0 0
Urea cycle R-HSA-70635 8.567853e-01 0.067 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.567853e-01 0.067 0 0
Sphingolipid catabolism R-HSA-9845614 8.567853e-01 0.067 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.587721e-01 0.066 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.587721e-01 0.066 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.600264e-01 0.065 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.605731e-01 0.065 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.605731e-01 0.065 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.644582e-01 0.063 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.648077e-01 0.063 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.675770e-01 0.062 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.682495e-01 0.061 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.682495e-01 0.061 0 0
Mitochondrial protein import R-HSA-1268020 8.687081e-01 0.061 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.696741e-01 0.061 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.696741e-01 0.061 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.696741e-01 0.061 0 0
p38MAPK events R-HSA-171007 8.696741e-01 0.061 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.696741e-01 0.061 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.696741e-01 0.061 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.696741e-01 0.061 0 0
Other semaphorin interactions R-HSA-416700 8.696741e-01 0.061 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.696741e-01 0.061 0 0
DNA Damage Reversal R-HSA-73942 8.696741e-01 0.061 0 0
Stabilization of p53 R-HSA-69541 8.697396e-01 0.061 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.697396e-01 0.061 0 0
Pentose phosphate pathway R-HSA-71336 8.697396e-01 0.061 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.697396e-01 0.061 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.697396e-01 0.061 0 0
Translation R-HSA-72766 8.722546e-01 0.059 0 0
The phototransduction cascade R-HSA-2514856 8.759057e-01 0.058 0 0
Iron uptake and transport R-HSA-917937 8.785081e-01 0.056 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.788523e-01 0.056 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.788523e-01 0.056 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.788523e-01 0.056 0 0
Diseases of Immune System R-HSA-5260271 8.788523e-01 0.056 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.788645e-01 0.056 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.829357e-01 0.054 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.829357e-01 0.054 0 0
Activation of SMO R-HSA-5635838 8.829357e-01 0.054 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.829357e-01 0.054 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.829357e-01 0.054 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.829357e-01 0.054 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.829357e-01 0.054 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.829357e-01 0.054 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.829357e-01 0.054 0 0
Atorvastatin ADME R-HSA-9754706 8.829357e-01 0.054 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.837771e-01 0.054 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.837771e-01 0.054 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.837771e-01 0.054 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.873937e-01 0.052 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.886842e-01 0.051 0 0
Disease R-HSA-1643685 8.900455e-01 0.051 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.912100e-01 0.050 0 0
Nucleotide biosynthesis R-HSA-8956320 8.912100e-01 0.050 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.948486e-01 0.048 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.948486e-01 0.048 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.948486e-01 0.048 0 0
Heme assimilation R-HSA-9927020 8.948486e-01 0.048 0 0
Phase 2 - plateau phase R-HSA-5576893 8.948486e-01 0.048 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.948486e-01 0.048 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.953924e-01 0.048 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.953924e-01 0.048 0 0
Translation of Structural Proteins R-HSA-9683701 8.953924e-01 0.048 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.973114e-01 0.047 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.977607e-01 0.047 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.982229e-01 0.047 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.982229e-01 0.047 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.016175e-01 0.045 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.028765e-01 0.044 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.030987e-01 0.044 0 0
Downstream TCR signaling R-HSA-202424 9.046313e-01 0.044 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.048343e-01 0.043 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.055498e-01 0.043 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.055498e-01 0.043 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.055498e-01 0.043 0 0
Glycogen storage diseases R-HSA-3229121 9.055498e-01 0.043 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.055498e-01 0.043 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.055498e-01 0.043 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.055498e-01 0.043 0 0
Catecholamine biosynthesis R-HSA-209905 9.055498e-01 0.043 0 0
Choline catabolism R-HSA-6798163 9.055498e-01 0.043 0 0
Uptake and function of anthrax toxins R-HSA-5210891 9.055498e-01 0.043 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.055498e-01 0.043 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.061434e-01 0.043 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.061434e-01 0.043 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.061434e-01 0.043 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.098733e-01 0.041 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.098733e-01 0.041 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.110623e-01 0.040 0 0
Interleukin-1 signaling R-HSA-9020702 9.114612e-01 0.040 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.151625e-01 0.039 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.151625e-01 0.039 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.151625e-01 0.039 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.173034e-01 0.037 0 0
Protein localization R-HSA-9609507 9.208800e-01 0.036 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.225104e-01 0.035 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.225104e-01 0.035 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.234239e-01 0.035 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.237973e-01 0.034 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.237973e-01 0.034 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.237973e-01 0.034 0 0
Diseases of hemostasis R-HSA-9671793 9.237973e-01 0.034 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.237973e-01 0.034 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.246841e-01 0.034 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.246841e-01 0.034 0 0
Hedgehog 'on' state R-HSA-5632684 9.246841e-01 0.034 0 0
Metabolism of cofactors R-HSA-8978934 9.246841e-01 0.034 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.275885e-01 0.033 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.276226e-01 0.033 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.315538e-01 0.031 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.315538e-01 0.031 0 0
Glycogen synthesis R-HSA-3322077 9.315538e-01 0.031 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.315538e-01 0.031 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.315538e-01 0.031 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.315538e-01 0.031 0 0
Signal transduction by L1 R-HSA-445144 9.315538e-01 0.031 0 0
Melanin biosynthesis R-HSA-5662702 9.315538e-01 0.031 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.315538e-01 0.031 0 0
GABA receptor activation R-HSA-977443 9.324914e-01 0.030 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.324914e-01 0.030 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.335056e-01 0.030 0 0
Synthesis of PC R-HSA-1483191 9.335056e-01 0.030 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.336437e-01 0.030 0 0
Hyaluronan metabolism R-HSA-2142845 9.336437e-01 0.030 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.336437e-01 0.030 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.378295e-01 0.028 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.379552e-01 0.028 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.385212e-01 0.028 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.385212e-01 0.028 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.385212e-01 0.028 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.385212e-01 0.028 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.385212e-01 0.028 0 0
Regulation of Apoptosis R-HSA-169911 9.392169e-01 0.027 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.413491e-01 0.026 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.413491e-01 0.026 0 0
Signaling by Hedgehog R-HSA-5358351 9.421098e-01 0.026 0 0
Stimuli-sensing channels R-HSA-2672351 9.426233e-01 0.026 0 0
Degradation of CDH1 R-HSA-9766229 9.430457e-01 0.025 0 0
G alpha (s) signalling events R-HSA-418555 9.441957e-01 0.025 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.441957e-01 0.025 0 0
Eicosanoids R-HSA-211979 9.447797e-01 0.025 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.447797e-01 0.025 0 0
Serine metabolism R-HSA-977347 9.447797e-01 0.025 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.453685e-01 0.024 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.453685e-01 0.024 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.473241e-01 0.024 0 0
Degradation of AXIN R-HSA-4641257 9.490568e-01 0.023 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.490568e-01 0.023 0 0
Metabolism of folate and pterines R-HSA-196757 9.490568e-01 0.023 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.504014e-01 0.022 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.504014e-01 0.022 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.504014e-01 0.022 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.504014e-01 0.022 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.504014e-01 0.022 0 0
ABC-family proteins mediated transport R-HSA-382556 9.520438e-01 0.021 0 0
ABC transporter disorders R-HSA-5619084 9.523737e-01 0.021 0 0
Cellular response to hypoxia R-HSA-1234174 9.526606e-01 0.021 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.532624e-01 0.021 0 0
Elastic fibre formation R-HSA-1566948 9.533875e-01 0.021 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.542237e-01 0.020 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.554511e-01 0.020 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.554511e-01 0.020 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.554511e-01 0.020 0 0
RAS processing R-HSA-9648002 9.573649e-01 0.019 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.584297e-01 0.018 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.590470e-01 0.018 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.599869e-01 0.018 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.599869e-01 0.018 0 0
Complex III assembly R-HSA-9865881 9.599869e-01 0.018 0 0
Glycogen metabolism R-HSA-8982491 9.610158e-01 0.017 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.610158e-01 0.017 0 0
Regulated Necrosis R-HSA-5218859 9.619322e-01 0.017 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.637915e-01 0.016 0 0
Tight junction interactions R-HSA-420029 9.640612e-01 0.016 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.640612e-01 0.016 0 0
Formation of the nephric duct R-HSA-9830364 9.640612e-01 0.016 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.640612e-01 0.016 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.640612e-01 0.016 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.641679e-01 0.016 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.643656e-01 0.016 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.643656e-01 0.016 0 0
RSV-host interactions R-HSA-9833110 9.645690e-01 0.016 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.660871e-01 0.015 0 0
COPII-mediated vesicle transport R-HSA-204005 9.671449e-01 0.015 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.673091e-01 0.014 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.674377e-01 0.014 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.674377e-01 0.014 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.674377e-01 0.014 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.677208e-01 0.014 0 0
TRP channels R-HSA-3295583 9.677208e-01 0.014 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.677208e-01 0.014 0 0
Peptide hormone metabolism R-HSA-2980736 9.695773e-01 0.013 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.710080e-01 0.013 0 0
Synthesis of PE R-HSA-1483213 9.710080e-01 0.013 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.710080e-01 0.013 0 0
Signaling by BMP R-HSA-201451 9.710080e-01 0.013 0 0
Telomere Extension By Telomerase R-HSA-171319 9.739606e-01 0.011 0 0
Pyroptosis R-HSA-5620971 9.739606e-01 0.011 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.743264e-01 0.011 0 0
Extension of Telomeres R-HSA-180786 9.743752e-01 0.011 0 0
Peroxisomal protein import R-HSA-9033241 9.743752e-01 0.011 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.751980e-01 0.011 0 0
Proteasome assembly R-HSA-9907900 9.751980e-01 0.011 0 0
Cellular response to chemical stress R-HSA-9711123 9.757738e-01 0.011 0 0
tRNA Aminoacylation R-HSA-379724 9.763893e-01 0.010 0 0
Platelet calcium homeostasis R-HSA-418360 9.766126e-01 0.010 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.766126e-01 0.010 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.773621e-01 0.010 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.773621e-01 0.010 0 0
Toll-like Receptor Cascades R-HSA-168898 9.786618e-01 0.009 0 0
Neurotransmitter clearance R-HSA-112311 9.789947e-01 0.009 0 0
UCH proteinases R-HSA-5689603 9.790604e-01 0.009 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.799736e-01 0.009 0 0
Formation of the cornified envelope R-HSA-6809371 9.800972e-01 0.009 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.811343e-01 0.008 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.811343e-01 0.008 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.811343e-01 0.008 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.820285e-01 0.008 0 0
Integrin cell surface interactions R-HSA-216083 9.820285e-01 0.008 0 0
Gluconeogenesis R-HSA-70263 9.828127e-01 0.008 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.830560e-01 0.007 0 0
Innate Immune System R-HSA-168249 9.840927e-01 0.007 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.843283e-01 0.007 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.843283e-01 0.007 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.844295e-01 0.007 0 0
Interferon alpha/beta signaling R-HSA-909733 9.844896e-01 0.007 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.847821e-01 0.007 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.863325e-01 0.006 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.863325e-01 0.006 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.863325e-01 0.006 0 0
Heme degradation R-HSA-189483 9.863325e-01 0.006 0 0
Kidney development R-HSA-9830369 9.868036e-01 0.006 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.869793e-01 0.006 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.877250e-01 0.005 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.877250e-01 0.005 0 0
RA biosynthesis pathway R-HSA-5365859 9.877250e-01 0.005 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.881355e-01 0.005 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.889757e-01 0.005 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.889757e-01 0.005 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.889757e-01 0.005 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.889757e-01 0.005 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.889757e-01 0.005 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.892070e-01 0.005 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.897598e-01 0.004 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.900990e-01 0.004 0 0
Triglyceride catabolism R-HSA-163560 9.900990e-01 0.004 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.900990e-01 0.004 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.900990e-01 0.004 0 0
Paracetamol ADME R-HSA-9753281 9.910352e-01 0.004 0 0
Voltage gated Potassium channels R-HSA-1296072 9.911079e-01 0.004 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.911079e-01 0.004 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.911079e-01 0.004 0 0
Collagen chain trimerization R-HSA-8948216 9.911079e-01 0.004 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.913641e-01 0.004 0 0
Purine salvage R-HSA-74217 9.920141e-01 0.003 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.920141e-01 0.003 0 0
Aspirin ADME R-HSA-9749641 9.920724e-01 0.003 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.928280e-01 0.003 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.928280e-01 0.003 0 0
Phospholipid metabolism R-HSA-1483257 9.929416e-01 0.003 0 0
ER-Phagosome pathway R-HSA-1236974 9.929950e-01 0.003 0 0
Tryptophan catabolism R-HSA-71240 9.935589e-01 0.003 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.935589e-01 0.003 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.938472e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.939319e-01 0.003 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.942154e-01 0.003 0 0
Maturation of spike protein R-HSA-9694548 9.942154e-01 0.003 0 0
Translation of Structural Proteins R-HSA-9694635 9.943838e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.948051e-01 0.002 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.948051e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.948504e-01 0.002 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.949083e-01 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.949265e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.952793e-01 0.002 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.953225e-01 0.002 0 0
Defensins R-HSA-1461973 9.958102e-01 0.002 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.958102e-01 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.958112e-01 0.002 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.959680e-01 0.002 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.961717e-01 0.002 0 0
Surfactant metabolism R-HSA-5683826 9.962374e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.962374e-01 0.002 0 0
Amine ligand-binding receptors R-HSA-375280 9.962374e-01 0.002 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.966210e-01 0.001 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.966210e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.966210e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.968371e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.970892e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.971410e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.972749e-01 0.001 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.974468e-01 0.001 0 0
Intraflagellar transport R-HSA-5620924 9.975528e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.978024e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.982278e-01 0.001 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.982278e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.983634e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.986208e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.986208e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.986700e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.989555e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.989652e-01 0.000 0 0
Digestion R-HSA-8935690 9.989652e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.990059e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.990707e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.991192e-01 0.000 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.991656e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.992419e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.992507e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.993272e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.993272e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.993272e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.993749e-01 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.993894e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.993939e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.993958e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.993958e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.993958e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.994463e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.995129e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.995129e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.995626e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.995874e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.996072e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.996501e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.996833e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.996833e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.996876e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.997157e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.997201e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.997942e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.997942e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.997942e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997942e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.997942e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.997989e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998124e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.998301e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998341e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998393e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998598e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998738e-01 0.000 0 0
Neddylation R-HSA-8951664 9.998830e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998952e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998965e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998979e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999036e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999130e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999210e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999299e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999335e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999371e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999396e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999483e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999630e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999667e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999688e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999809e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999826e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999858e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999875e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999882e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999888e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999904e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999938e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999955e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999961e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999961e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999967e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999977e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999977e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999979e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999986e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999986e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999990e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999993e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999995e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999997e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999997e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways