LATS1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00170 S43 Sugiyama AIP XAP2 GELPDFQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELI
O14980 S1055 Sugiyama XPO1 CRM1 LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15013 S1304 Sugiyama ARHGEF10 KIAA0294 ssGsLsLsHGsssLEHRSEDsTIyDLLKDPVSLRSKARRAK
O43175 S12 Sugiyama PHGDH PGDH3 _________MAFANLRKVLIsDsLDPCCRKILQDGGLQVVE
O43623 T208 PSP SNAI2 SLUG SLUGH KICGKAFSRPWLLQGHIRTHtGEKPFSCPHCNRAFADRSNL
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75874 S9 Sugiyama IDH1 PICD ____________MSKKIsGGsVVEMQGDEMTRIIWELIKEK
O94885 S407 PSP SASH1 KIAA0790 PEPE1 sLtEGEMKKGLGSLSHGRtCsFGGFDLTNRSLHVGSNNSDP
O95633 T228 Sugiyama FSTL3 FLRG UNQ674/PRO1308 QELCGNNNVTYISSCHMRQAtCFLGRSIGVRHAGSCAGTPE
O95721 S204 Sugiyama SNAP29 MSTDAYPKNPHLRAYHQKIDsNLDELsMGLGRLKDIALGMQ
O95835 S1016 Sugiyama LATS1 WARTS LGKNGADEIKAHPFFKtIDFsSDLRQQSASYIPKITHPTDT
O95835 S1049 EPSD|PSP LATS1 WARTS KITHPTDTSNFDPVDPDKLWsDDNEEENVNDtLNGWYKNGK
O95835 S593 Sugiyama LATS1 WARTS yEsISKPSKEDQPSLPKEDEsEKSYENVDSGDKEKKQItts
O95835 S613 Sugiyama LATS1 WARTS sEKSYENVDSGDKEKKQIttsPItVRKNKKDEERRESRIQS
O95835 S674 EPSD|PSP|Sugiyama LATS1 WARTS HQQRLHRKKQLENEMMRVGLsQDAQDQMRKMLCQKESNYIR
O95835 S864 Sugiyama LATS1 WARTS LTDFGLCTGFRWTHDSKYYQsGDHPRQDsMDFsNEWGDPSS
O95835 S872 Sugiyama LATS1 WARTS GFRWTHDSKYYQsGDHPRQDsMDFsNEWGDPSSCRCGDRLK
O95835 S876 Sugiyama LATS1 WARTS THDSKYYQsGDHPRQDsMDFsNEWGDPSSCRCGDRLKPLER
O95835 S909 EPSD|PSP LATS1 WARTS DRLKPLERRAARQHQRCLAHsLVGTPNYIAPEVLLRTGYTQ
O95835 T1060 Sugiyama LATS1 WARTS DPVDPDKLWsDDNEEENVNDtLNGWYKNGKHPEHAFYEFtF
O95835 T1079 Sugiyama LATS1 WARTS DtLNGWYKNGKHPEHAFYEFtFRRFFDDNGYPYNYPKPIEY
O95835 T616 Sugiyama LATS1 WARTS SYENVDSGDKEKKQIttsPItVRKNKKDEERRESRIQSYsP
P00558 S399 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04049 S259 EPSD|PSP RAF1 RAF tFNtssPSSEGSLSQRQRststPNVHMVsttLPVDSRMIED
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 S173 Sugiyama ANXA1 ANX1 LPC1 NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04632 T85 Sugiyama CAPNS1 CAPN4 CAPNS VIsAISEAAAQYNPEPPPPRtHysNIEANEsEEVRQFRRLF
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S83 Sugiyama HSPB1 HSP27 HSP28 IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07205 S399 Sugiyama PGK2 PGKB CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07900 S391 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 S383 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08708 S89 Sugiyama RPS17 RPS17L ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P09382 S63 Sugiyama LGALS1 CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09661 S212 Sugiyama SNRPA1 KKGGPsPGDVEAIKNAIANAstLAEVERLKGLLQsGQIPGR
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10809 S70 Sugiyama HSPD1 HSP60 AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11387 S10 Sugiyama TOP1 ___________MsGDHLHNDsQIEADFRLNDsHKHKDKHKD
P11908 T285 SIGNOR|PSP PRPS2 AFEAVVVTNTIPQEDKMKHCtKIQVIDISMILAEAIRRTHN
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P11940 Y194 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 KSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLFGKF
P12268 S416 Sugiyama IMPDH2 IMPD2 APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P13010 S318 Sugiyama XRCC5 G22P2 NDDDETEVLKEDIIQGFRyGsDIVPFSKVDEEQMKYKSEGK
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S732 Sugiyama EEF2 EF2 DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P20042 S67 Sugiyama EIF2S2 EIF2B EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK
P22059 S190 Sugiyama OSBP OSBP1 QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23381 S358 Sugiyama WARS1 IFI53 WARS WRS TFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTKVNKHAFs
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692 S60 Sugiyama EEF1D EF1D ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P29692 S74 Sugiyama EEF1D EF1D RENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVENQsL
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086 S54 Sugiyama PEBP1 PBP PEBP VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP
P30101 Y356 Sugiyama PDIA3 ERP57 ERP60 GRP58 FVMQEEFsRDGKALERFLQDyFDGNLKRyLKsEPIPESNDG
P31153 Y235 Sugiyama MAT2A AMS2 MATA2 LDEMRDALKEKVIKAVVPAKyLDEDtIyHLQPsGRFVIGGP
P32969 Y180 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P33176 S950 Sugiyama KIF5B KNS KNS1 PAAsPtHPSAIRGGGAFVQNsQPVAVRGGGGKQV_______
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932 S76 Sugiyama HSPA4 APG2 HSPH2 VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P34932 Y597 Sugiyama HSPA4 APG2 HSPH2 VDLPIENQLLWQIDREMLNLyIENEGKMIMQDKLEKERNDA
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P40855 S147 Sugiyama PEX19 HK33 PXF OK/SW-cl.22 SCLKETLSGLAKNATDLQNssMsEEELTKAMEGLGMDEGDG
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243 S195 Sugiyama MATR3 KIAA0723 RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46937 S109 GPS6|EPSD|PSP|Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P46937 S127 GPS6|SIGNOR|EPSD|PSP YAP1 YAP65 QAstDAGtAGALtPQHVRAHssPAsLQLGAVsPGtLtPtGV
P46937 S164 GPS6|EPSD|PSP YAP1 YAP65 PtGVVsGPAAtPTAQHLRQssFEIPDDVPLPAGWEMAKTSS
P46937 S381 PSP YAP1 YAP65 tQNPVssPGMsQELRTMttNssDPFLNsGtyHsRDEstDsG
P46937 S397 GPS6|SIGNOR|EPSD YAP1 YAP65 MttNssDPFLNsGtyHsRDEstDsGLsMssysVPRtPDDFL
P46937 S400 Sugiyama YAP1 YAP65 NssDPFLNsGtyHsRDEstDsGLsMssysVPRtPDDFLNsV
P46937 S61 GPS6|EPSD|PSP YAP1 YAP65 tQAAPQAPPAGHQIVHVRGDsEtDLEALFNAVMNPKtANVP
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321 S659 Sugiyama NASP IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst
P50990 S23 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 LHVPKAPGFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTT
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116 T598 Sugiyama FXR2 FMR1L2 DESRPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRA
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P60891 S285 SIGNOR|PSP PRPS1 CFEAVVVTNTIPQEDKMKHCsKIQVIDISMILAEAIRRTHN
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61313 Y6 Sugiyama RPL15 EC45 TCBAP0781 _______________MGAYKyIQELWRKKQSDVMRFLLRVR
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62241 S160 Sugiyama RPS8 OK/SW-cl.83 KRSKKIQKKYDERKKNAKIssLLEEQFQQGKLLACIASRPG
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01650 S31 Sugiyama SLC7A5 CD98LC LAT1 MPE16 LAAPAAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNIT
Q02241 S716 EPSD|PSP KIF23 KNSL5 MKLP1 AQISNGQQLMSQPQLHRRsNsCssISVASCISEWEQKIPTy
Q02241 S814 EPSD|PSP KIF23 KNSL5 MKLP1 LLFQPDQNAPPIRLRHRRsRsAGDRWVDHKPASNMQTETVM
Q06323 S55 Sugiyama PSME1 IFI5111 KKIsELDAFLKEPALNEANLsNLKAPLDIPVPDPVKEKEKE
Q06830 S152 Sugiyama PRDX1 PAGA PAGB TDPX2 IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q07021 T214 Sugiyama C1QBP GC1QBP HABP1 SF2P32 GQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDSLDWA
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q13155 S48 Sugiyama AIMP2 JTV1 PRO0992 PNVHGRSyGPAPGAGHVQEEsNLsLQALESRQDDILKRLYE
Q13283 S67 Sugiyama G3BP1 G3BP sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13283 T71 Sugiyama G3BP1 G3BP PADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLNDGVV
Q13283 Y19 Sugiyama G3BP1 G3BP __MVMEKPsPLLVGREFVRQyytLLNQAPDMLHRFYGKNss
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13310 Y194 Sugiyama PABPC4 APP1 PABP4 KSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELFsQF
Q14103 S271 Sugiyama HNRNPD AUF1 HNRPD KCEIKVAMSKEQyQQQQQWGsRGGFAGRARGRGGGPSQNWN
Q14152 S1256 Sugiyama EIF3A EIF3S10 KIAA0139 EDRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRE
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q14669 S987 Sugiyama TRIP12 KIAA0045 ULF AAtHAAADLGsPSLQHSRDDsLDLsPQGRLsDVLKRKRLPK
Q14847 S99 Sugiyama LASP1 MLN50 ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14872 S152 SIGNOR|PSP MTF1 TKRKEVKRYQCTFEGCPRTYsTAGNLRTHQKTHRGEYTFVC
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15293 Y115 Sugiyama RCN1 RCN GDGFVttEELKtWIKRVQKRyIFDNVAKVWKDYDRDKDDKI
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16576 S163 Sugiyama RBBP7 RBAP46 tPssDVLVFDyTKHPAKPDPsGECNPDLRLRGHQKEGYGLS
Q16584 T477 PSP MAP3K11 MLK3 PTK1 SPRK LTLLLQQVDRERPHVRRRRGtFKRSKLRARDGGERISMPLD
Q16658 T239 Sugiyama FSCN1 FAN1 HSN SNL GKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALEQs
Q4VCS5 S175 SIGNOR|PSP AMOT KIAA1071 GKMHQDEGLRDLKQGHVRSLsERLMQMSLATSGVKAHPPVT
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q5H9R7 S579 Sugiyama PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q5T5C0 S692 Sugiyama STXBP5 LLGL3 YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q674X7 S318 Sugiyama KAZN C1orf196 KAZ KIAA1026 HRIHFB2003 PPHPADRQAVRVsPCHSRQPsVISDASAAEGDRsstPSDIN
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z417 S655 Sugiyama NUFIP2 KIAA1321 PIG1 LGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsIWNL
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8N122 S606 PSP RPTOR KIAA1303 RAPTOR QNFDSARWCGVRDSAHEKLYsLLSDPIPEVRCAAVFALGTF
Q8NHZ8 T7 SIGNOR|EPSD|PSP CDC26 ANAPC12 C9orf17 ______________MLRRKPtRLELKLDDIEEFENIRKDLE
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8WWI1 S709 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 VERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQKIKS
Q8WX93 S479 Sugiyama PALLD KIAA0992 CGI-151 VLECRVRGAPPLQVQWFRQGsEIQDsPDFRILQKKPRSTAE
Q92769 S422 Sugiyama HDAC2 PDKRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGA
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99614 S90 Sugiyama TTC1 TPR1 FEEEPGADKVENKsNEDVNssELDEEyLIELEKNMSDEEKQ
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BTU6 S460 Sugiyama PI4K2A PLHLVQMPPVIVETARSHQRsssEsyTQsFQSRKPFFSWW_
Q9BTU6 S462 Sugiyama PI4K2A HLVQMPPVIVETARSHQRsssEsyTQsFQSRKPFFSWW___
Q9BY44 S526 Sugiyama EIF2A CDA02 MSTP004 MSTP089 sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9C0C2 S920 Sugiyama TNKS1BP1 KIAA1741 TAB182 QDANEQGQDLGKRDHHGRyssQDADEQDWEFQKRDVsLGTy
Q9GZV5 S89 SIGNOR|PSP WWTR1 TAZ SsGGHPGPRLAGGAQHVRsHssPAsLQLGtGAGAAGsPAQQ
Q9NPD3 S240 Sugiyama EXOSC4 RRP41 SKI6 AARDVHTLLDRVVRQHVREAsILLGD_______________
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NQS7 S894 EPSD|PSP INCENP PLDLEDIFKKSKPRYHKRtssAVWNsPPLQGARVPssLAYs
Q9NRM7 T1041 Sugiyama LATS2 KPM AWDtLtsPNNKHPEHAFYEFtFRRFFDDNGyPFRCPKPSGA
Q9NZN8 S242 Sugiyama CNOT2 CDC36 NOT2 HSPC131 MSTP046 VTGLDLSDFPALADRNRREGsGNPtPLINPLAGRAPYVGMV
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y5U2 S86 Sugiyama TSSC4 PSPPSGLLPATVQPFHLRGMssTFSQRsRDIFDCLEGAARR
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Signaling by Hippo R-HSA-2028269 7.024593e-07 6.153 1 1
Apoptotic cleavage of cellular proteins R-HSA-111465 1.410560e-05 4.851 0 0
Gene expression (Transcription) R-HSA-74160 7.578956e-05 4.120 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.504602e-04 3.601 0 0
Cell Cycle R-HSA-1640170 2.087168e-04 3.680 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.210173e-04 3.656 0 0
Apoptotic execution phase R-HSA-75153 3.030653e-04 3.518 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.046622e-04 3.393 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.046622e-04 3.393 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.365826e-04 3.360 0 0
Death Receptor Signaling R-HSA-73887 3.987149e-04 3.399 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.681860e-04 3.330 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.204052e-04 3.284 0 0
Regulation of TP53 Activity R-HSA-5633007 6.227323e-04 3.206 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.134820e-03 2.945 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.199366e-03 2.921 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.171130e-03 2.931 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.142845e-03 2.942 0 0
G alpha (12/13) signalling events R-HSA-416482 1.416369e-03 2.849 0 0
Axon guidance R-HSA-422475 1.323593e-03 2.878 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.371099e-03 2.863 0 0
Activation of RAC1 R-HSA-428540 1.732158e-03 2.761 0 0
Nervous system development R-HSA-9675108 1.766651e-03 2.753 0 0
Polo-like kinase mediated events R-HSA-156711 2.112262e-03 2.675 0 0
RNA Polymerase II Transcription R-HSA-73857 2.092448e-03 2.679 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.112262e-03 2.675 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.442453e-03 2.612 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.743899e-03 2.562 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.919289e-03 2.535 0 0
Chromatin modifying enzymes R-HSA-3247509 2.968623e-03 2.527 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.834370e-03 2.416 0 0
TNF signaling R-HSA-75893 3.830168e-03 2.417 0 0
Membrane Trafficking R-HSA-199991 3.565767e-03 2.448 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.695029e-03 2.432 0 0
NRAGE signals death through JNK R-HSA-193648 3.830168e-03 2.417 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.893891e-03 2.410 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.259236e-03 2.371 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.441518e-03 2.352 0 0
mRNA Splicing R-HSA-72172 4.820309e-03 2.317 0 0
Cell Cycle Checkpoints R-HSA-69620 4.959724e-03 2.305 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.658522e-03 2.247 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.793914e-03 2.237 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.820144e-03 2.235 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 5.820147e-03 2.235 0 0
Chromatin organization R-HSA-4839726 6.104393e-03 2.214 0 0
G0 and Early G1 R-HSA-1538133 6.219596e-03 2.206 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.377029e-03 2.195 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.117188e-03 2.148 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.915718e-03 2.160 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.117188e-03 2.148 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.272152e-03 2.138 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 7.491261e-03 2.125 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.536809e-03 2.123 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.107312e-03 2.091 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.414125e-03 2.075 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.010134e-02 1.996 0 0
Generic Transcription Pathway R-HSA-212436 9.779852e-03 2.010 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.066537e-02 1.972 0 0
Ephrin signaling R-HSA-3928664 1.022789e-02 1.990 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.045567e-02 1.981 0 0
Cell Cycle, Mitotic R-HSA-69278 1.051029e-02 1.978 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.073332e-02 1.969 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.209822e-02 1.917 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.160355e-02 1.935 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.209822e-02 1.917 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.229733e-02 1.910 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.418783e-02 1.848 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.418783e-02 1.848 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.418783e-02 1.848 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.418783e-02 1.848 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.467711e-02 1.833 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.318325e-02 1.880 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.418783e-02 1.848 0 0
Signaling by VEGF R-HSA-194138 1.433783e-02 1.844 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.354682e-02 1.868 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.506788e-02 1.822 0 0
Signaling by ROBO receptors R-HSA-376176 1.580052e-02 1.801 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.163133e-02 1.665 0 0
Regulation of TP53 Expression R-HSA-6804754 2.163133e-02 1.665 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.163133e-02 1.665 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.163133e-02 1.665 0 0
Regulation of cortical dendrite branching R-HSA-8985801 2.163133e-02 1.665 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.163133e-02 1.665 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.163133e-02 1.665 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.163133e-02 1.665 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.163133e-02 1.665 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.163133e-02 1.665 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.163133e-02 1.665 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.163133e-02 1.665 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.163133e-02 1.665 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.163133e-02 1.665 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.932112e-02 1.714 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.932112e-02 1.714 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.628667e-02 1.788 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.628667e-02 1.788 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.807051e-02 1.743 0 0
mRNA 3'-end processing R-HSA-72187 2.151478e-02 1.667 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.187031e-02 1.660 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.906901e-02 1.720 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.998736e-02 1.699 0 0
Semaphorin interactions R-HSA-373755 2.042935e-02 1.690 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.906488e-02 1.720 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.906488e-02 1.720 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.879567e-02 1.726 0 0
Signaling by ALK in cancer R-HSA-9700206 1.879567e-02 1.726 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.770029e-02 1.752 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.310564e-02 1.636 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.355941e-02 1.628 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.402321e-02 1.619 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.402321e-02 1.619 0 0
MTOR signalling R-HSA-165159 2.423761e-02 1.616 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.469313e-02 1.607 0 0
Formation of the ureteric bud R-HSA-9830674 2.493089e-02 1.603 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.493089e-02 1.603 0 0
G2/M Transition R-HSA-69275 2.503372e-02 1.601 0 0
DNA Double Strand Break Response R-HSA-5693606 2.765216e-02 1.558 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.723025e-02 1.565 0 0
Kidney development R-HSA-9830369 2.765216e-02 1.558 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.960831e-02 1.529 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.960831e-02 1.529 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.078669e-02 1.512 0 0
Disorders of Developmental Biology R-HSA-9675151 3.165032e-02 1.500 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.165032e-02 1.500 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.165032e-02 1.500 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.184377e-02 1.497 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.184377e-02 1.497 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.258839e-02 1.487 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.258839e-02 1.487 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.570686e-02 1.447 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.226280e-02 1.491 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.269508e-02 1.486 0 0
FLT3 signaling in disease R-HSA-9682385 3.598342e-02 1.444 0 0
Rab regulation of trafficking R-HSA-9007101 3.639284e-02 1.439 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 4.525457e-02 1.344 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.525457e-02 1.344 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.525457e-02 1.344 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.759466e-02 1.425 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.510380e-02 1.346 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.181969e-02 1.379 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.984666e-02 1.400 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.984666e-02 1.400 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.984666e-02 1.400 0 0
HIV elongation arrest and recovery R-HSA-167287 4.426623e-02 1.354 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.426623e-02 1.354 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.947680e-02 1.404 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.709007e-02 1.327 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.059707e-02 1.392 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.313858e-02 1.365 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.158849e-02 1.381 0 0
Centrosome maturation R-HSA-380287 4.712754e-02 1.327 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.201922e-02 1.377 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.201922e-02 1.377 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.317819e-02 1.365 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.960422e-02 1.402 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.525457e-02 1.344 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.946365e-02 1.404 0 0
Mitotic Prophase R-HSA-68875 4.219577e-02 1.375 0 0
HIV Life Cycle R-HSA-162587 4.133105e-02 1.384 0 0
MTF1 activates gene expression R-HSA-5660489 4.525457e-02 1.344 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.181969e-02 1.379 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.317819e-02 1.365 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.022002e-02 1.396 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.317819e-02 1.365 0 0
Heme signaling R-HSA-9707616 4.619359e-02 1.335 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.759466e-02 1.425 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.984666e-02 1.400 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.751864e-02 1.323 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.861937e-02 1.313 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.938678e-02 1.306 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.938678e-02 1.306 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 5.447613e-02 1.264 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 5.447613e-02 1.264 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.941157e-02 1.226 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.941157e-02 1.226 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.941157e-02 1.226 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.329573e-02 1.273 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.395212e-02 1.268 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.921990e-02 1.228 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.921990e-02 1.228 0 0
HIV Transcription Elongation R-HSA-167169 5.121443e-02 1.291 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.121443e-02 1.291 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.121443e-02 1.291 0 0
Meiotic synapsis R-HSA-1221632 5.871418e-02 1.231 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.619366e-02 1.250 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.559974e-02 1.255 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.862527e-02 1.232 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.395212e-02 1.268 0 0
Mitotic Prometaphase R-HSA-68877 5.707105e-02 1.244 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.121443e-02 1.291 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.711447e-02 1.243 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.362565e-02 1.271 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.962269e-02 1.225 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.980984e-02 1.223 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.980984e-02 1.223 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 6.214773e-02 1.207 0 0
Disorders of Nervous System Development R-HSA-9697154 6.214773e-02 1.207 0 0
Pervasive developmental disorders R-HSA-9005895 6.214773e-02 1.207 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.214773e-02 1.207 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.214773e-02 1.207 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.214773e-02 1.207 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 7.485974e-02 1.126 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 7.485974e-02 1.126 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 7.485974e-02 1.126 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 7.485974e-02 1.126 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 7.485974e-02 1.126 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 7.163353e-02 1.145 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 7.060211e-02 1.151 0 0
Signaling by EGFR R-HSA-177929 7.164084e-02 1.145 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.435210e-02 1.129 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.163353e-02 1.145 0 0
Netrin-1 signaling R-HSA-373752 7.505791e-02 1.125 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.476047e-02 1.189 0 0
Homology Directed Repair R-HSA-5693538 7.236071e-02 1.140 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.060211e-02 1.151 0 0
M Phase R-HSA-68886 7.448366e-02 1.128 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.485974e-02 1.126 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.060211e-02 1.151 0 0
Regulated Necrosis R-HSA-5218859 6.747234e-02 1.171 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 7.163353e-02 1.145 0 0
mTORC1-mediated signalling R-HSA-166208 7.435210e-02 1.129 0 0
Developmental Biology R-HSA-1266738 7.535992e-02 1.123 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 7.485974e-02 1.126 0 0
Cell-Cell communication R-HSA-1500931 6.521270e-02 1.186 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.485974e-02 1.126 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.060211e-02 1.151 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.747234e-02 1.171 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.571217e-02 1.121 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.671280e-02 1.115 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.671280e-02 1.115 0 0
Signal Transduction R-HSA-162582 7.898825e-02 1.102 1 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.204762e-02 1.086 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.279250e-02 1.082 0 0
Nuclear import of Rev protein R-HSA-180746 8.309937e-02 1.080 0 0
Signaling by RAS mutants R-HSA-6802949 8.609652e-02 1.065 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.609652e-02 1.065 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.609652e-02 1.065 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.609652e-02 1.065 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.609652e-02 1.065 0 0
Diseases of DNA repair R-HSA-9675135 8.609652e-02 1.065 0 0
Metabolism of non-coding RNA R-HSA-194441 8.612586e-02 1.065 0 0
snRNP Assembly R-HSA-191859 8.612586e-02 1.065 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.619315e-02 1.065 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.059877e-01 0.975 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.059877e-01 0.975 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.059877e-01 0.975 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.059877e-01 0.975 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.059877e-01 0.975 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.059877e-01 0.975 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.059877e-01 0.975 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 9.141674e-02 1.039 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 9.141674e-02 1.039 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 9.238759e-02 1.034 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.010296e-02 1.045 0 0
Deadenylation of mRNA R-HSA-429947 9.010296e-02 1.045 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.975800e-02 1.047 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.078330e-01 0.967 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.078330e-01 0.967 0 0
HATs acetylate histones R-HSA-3214847 9.477237e-02 1.023 0 0
Signaling by ERBB2 R-HSA-1227986 9.129850e-02 1.040 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.018346e-01 0.992 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 9.010296e-02 1.045 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.042276e-01 0.982 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.042276e-01 0.982 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 8.667725e-02 1.062 0 0
Mitotic Spindle Checkpoint R-HSA-69618 9.898239e-02 1.004 0 0
G2/M Checkpoints R-HSA-69481 1.076776e-01 0.968 0 0
HDMs demethylate histones R-HSA-3214842 9.852957e-02 1.006 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.038726e-01 0.983 0 0
Cellular Senescence R-HSA-2559583 9.930246e-02 1.003 0 0
Vesicle-mediated transport R-HSA-5653656 8.871911e-02 1.052 0 0
ISG15 antiviral mechanism R-HSA-1169408 9.884008e-02 1.005 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 9.141674e-02 1.039 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 9.238759e-02 1.034 0 0
Formation of the anterior neural plate R-HSA-9823739 9.238759e-02 1.034 0 0
Glycolysis R-HSA-70171 9.898239e-02 1.004 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 9.010296e-02 1.045 0 0
Neurodegenerative Diseases R-HSA-8863678 9.010296e-02 1.045 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.089162e-01 0.963 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.089162e-01 0.963 0 0
SOS-mediated signalling R-HSA-112412 1.089162e-01 0.963 0 0
Regulation of PTEN localization R-HSA-8948747 1.089162e-01 0.963 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.090917e-01 0.962 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.091967e-01 0.962 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.113175e-01 0.953 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 1.125313e-01 0.949 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.153002e-01 0.938 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.153002e-01 0.938 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.164254e-01 0.934 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 1.546959e-01 0.811 0 0
XAV939 stabilizes AXIN R-HSA-5545619 1.546959e-01 0.811 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 1.546959e-01 0.811 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 1.546959e-01 0.811 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 1.546959e-01 0.811 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.546959e-01 0.811 0 0
Type I hemidesmosome assembly R-HSA-446107 1.272066e-01 0.895 0 0
WNT mediated activation of DVL R-HSA-201688 1.461501e-01 0.835 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.461501e-01 0.835 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.274792e-01 0.895 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.274792e-01 0.895 0 0
PKA activation in glucagon signalling R-HSA-164378 1.400924e-01 0.854 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.258678e-01 0.900 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.258678e-01 0.900 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.356208e-01 0.868 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.356208e-01 0.868 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.456691e-01 0.837 0 0
Translation initiation complex formation R-HSA-72649 1.384395e-01 0.859 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.534255e-01 0.814 0 0
Transcription of the HIV genome R-HSA-167172 1.386592e-01 0.858 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.456691e-01 0.837 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.435250e-01 0.843 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.461501e-01 0.835 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.400924e-01 0.854 0 0
EPH-Ephrin signaling R-HSA-2682334 1.239545e-01 0.907 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 1.461501e-01 0.835 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.461501e-01 0.835 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.492825e-01 0.826 0 0
Meiosis R-HSA-1500620 1.555448e-01 0.808 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.244658e-01 0.905 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.514062e-01 0.820 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.351239e-01 0.869 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.386592e-01 0.858 0 0
Lipophagy R-HSA-9613354 1.461501e-01 0.835 0 0
Ca-dependent events R-HSA-111996 1.521453e-01 0.818 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.356208e-01 0.868 0 0
Specification of the neural plate border R-HSA-9834899 1.531035e-01 0.815 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.190124e-01 0.924 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.272066e-01 0.895 0 0
Apoptotic factor-mediated response R-HSA-111471 1.400924e-01 0.854 0 0
DNA Repair R-HSA-73894 1.279772e-01 0.893 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.224117e-01 0.912 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.414512e-01 0.849 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.168962e-01 0.932 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.469048e-01 0.833 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.557752e-01 0.808 0 0
Programmed Cell Death R-HSA-5357801 1.357611e-01 0.867 0 0
Cellular response to heat stress R-HSA-3371556 1.422332e-01 0.847 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.546959e-01 0.811 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.400924e-01 0.854 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.534255e-01 0.814 0 0
Apoptosis R-HSA-109581 1.404048e-01 0.853 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.435250e-01 0.843 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.269504e-01 0.896 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.351239e-01 0.869 0 0
Sensory processing of sound R-HSA-9659379 1.199022e-01 0.921 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.461501e-01 0.835 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.272066e-01 0.895 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.190124e-01 0.924 0 0
Interleukin-37 signaling R-HSA-9008059 1.456691e-01 0.837 0 0
EGFR downregulation R-HSA-182971 1.559970e-01 0.807 0 0
Downstream signal transduction R-HSA-186763 1.559970e-01 0.807 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.563765e-01 0.806 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.589952e-01 0.799 0 0
TBC/RABGAPs R-HSA-8854214 1.609761e-01 0.793 0 0
Metabolism of RNA R-HSA-8953854 1.649783e-01 0.783 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.656213e-01 0.781 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.656213e-01 0.781 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.656213e-01 0.781 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.656213e-01 0.781 0 0
Nephrin family interactions R-HSA-373753 1.664766e-01 0.779 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.665885e-01 0.778 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.678492e-01 0.775 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.678492e-01 0.775 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.678492e-01 0.775 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 2.007532e-01 0.697 0 0
Signaling by RAS GAP mutants R-HSA-9753510 2.007532e-01 0.697 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.443036e-01 0.612 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.443036e-01 0.612 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.443036e-01 0.612 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.854834e-01 0.544 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.854834e-01 0.544 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.854834e-01 0.544 0 0
ATP sensitive Potassium channels R-HSA-1296025 2.854834e-01 0.544 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.854834e-01 0.544 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.855069e-01 0.732 0 0
IRS activation R-HSA-74713 3.244216e-01 0.489 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 3.244216e-01 0.489 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.261197e-01 0.646 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.261197e-01 0.646 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.612401e-01 0.442 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 3.612401e-01 0.442 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.612401e-01 0.442 0 0
Cam-PDE 1 activation R-HSA-111957 3.612401e-01 0.442 0 0
PDE3B signalling R-HSA-165160 3.612401e-01 0.442 0 0
PKB-mediated events R-HSA-109703 3.612401e-01 0.442 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.612401e-01 0.442 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.612401e-01 0.442 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.466705e-01 0.608 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.466705e-01 0.608 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.801759e-01 0.744 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.801759e-01 0.744 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.941662e-01 0.712 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.941662e-01 0.712 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.672812e-01 0.573 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.672812e-01 0.573 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.672812e-01 0.573 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.960541e-01 0.402 0 0
DCC mediated attractive signaling R-HSA-418885 2.878842e-01 0.541 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.878842e-01 0.541 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.878842e-01 0.541 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.375420e-01 0.624 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.084194e-01 0.511 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.289726e-01 0.368 0 0
Netrin mediated repulsion signals R-HSA-418886 4.289726e-01 0.368 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.289726e-01 0.368 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 4.289726e-01 0.368 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.288330e-01 0.483 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.673056e-01 0.573 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.690939e-01 0.772 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.490774e-01 0.457 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.490774e-01 0.457 0 0
Regulation by c-FLIP R-HSA-3371378 4.600987e-01 0.337 0 0
phospho-PLA2 pathway R-HSA-111995 4.600987e-01 0.337 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.600987e-01 0.337 0 0
Dimerization of procaspase-8 R-HSA-69416 4.600987e-01 0.337 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.600987e-01 0.337 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.600987e-01 0.337 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.684352e-01 0.774 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.483512e-01 0.605 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.895300e-01 0.310 0 0
CASP8 activity is inhibited R-HSA-5218900 4.895300e-01 0.310 0 0
ALK mutants bind TKIs R-HSA-9700645 4.895300e-01 0.310 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.817938e-01 0.740 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 4.275940e-01 0.369 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.120715e-01 0.506 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.348190e-01 0.629 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.348190e-01 0.629 0 0
Striated Muscle Contraction R-HSA-390522 3.882251e-01 0.411 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.464558e-01 0.350 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 4.464558e-01 0.350 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.633397e-01 0.579 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.633397e-01 0.579 0 0
FGFR2 alternative splicing R-HSA-6803529 4.649639e-01 0.333 0 0
Notch-HLH transcription pathway R-HSA-350054 4.649639e-01 0.333 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.649639e-01 0.333 0 0
RET signaling R-HSA-8853659 4.326841e-01 0.364 0 0
PPARA activates gene expression R-HSA-1989781 2.678433e-01 0.572 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.386885e-01 0.470 0 0
Amino acids regulate mTORC1 R-HSA-9639288 4.455018e-01 0.351 0 0
HDACs deacetylate histones R-HSA-3214815 4.698148e-01 0.328 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.818243e-01 0.317 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 2.802686e-01 0.552 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.277995e-01 0.484 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.021695e-01 0.520 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.022884e-01 0.694 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.275940e-01 0.369 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.708933e-01 0.431 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.997778e-01 0.699 0 0
Integrin signaling R-HSA-354192 3.732038e-01 0.428 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.587528e-01 0.587 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.083990e-01 0.389 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.798487e-01 0.553 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.903840e-01 0.309 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.700084e-01 0.770 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.277995e-01 0.484 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.882251e-01 0.411 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.288330e-01 0.483 0 0
GAB1 signalosome R-HSA-180292 3.691104e-01 0.433 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.984359e-01 0.702 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.084129e-01 0.681 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.084194e-01 0.511 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.430601e-01 0.354 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 4.899729e-01 0.310 0 0
Pyroptosis R-HSA-5620971 2.974645e-01 0.527 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.984359e-01 0.702 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.229148e-01 0.652 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 4.962738e-01 0.304 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 2.261197e-01 0.646 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.612401e-01 0.442 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.612401e-01 0.442 0 0
Formation of axial mesoderm R-HSA-9796292 2.466705e-01 0.608 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.289726e-01 0.368 0 0
TGFBR3 expression R-HSA-9839394 2.523599e-01 0.598 0 0
Trafficking of AMPA receptors R-HSA-399719 3.429701e-01 0.465 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.008517e-01 0.300 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.899729e-01 0.310 0 0
G-protein beta:gamma signalling R-HSA-397795 3.732038e-01 0.428 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.266351e-01 0.486 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.266351e-01 0.486 0 0
RNA Polymerase III Transcription R-HSA-74158 2.229148e-01 0.652 0 0
Hedgehog 'off' state R-HSA-5610787 4.287236e-01 0.368 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.457175e-01 0.461 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.261197e-01 0.646 0 0
RNA Polymerase I Transcription R-HSA-73864 3.519210e-01 0.454 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.229268e-01 0.491 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.323327e-01 0.478 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.854834e-01 0.544 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.854834e-01 0.544 0 0
Formation of the posterior neural plate R-HSA-9832991 1.855069e-01 0.732 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 3.244216e-01 0.489 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 3.244216e-01 0.489 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.057040e-01 0.687 0 0
GRB2 events in EGFR signaling R-HSA-179812 2.261197e-01 0.646 0 0
Killing mechanisms R-HSA-9664420 3.084194e-01 0.511 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.084194e-01 0.511 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.289726e-01 0.368 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.347357e-01 0.629 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.277995e-01 0.484 0 0
Calcineurin activates NFAT R-HSA-2025928 4.895300e-01 0.310 0 0
MAP2K and MAPK activation R-HSA-5674135 2.957008e-01 0.529 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.081537e-01 0.511 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.130786e-01 0.671 0 0
Adipogenesis R-HSA-9843745 3.123671e-01 0.505 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.278441e-01 0.369 0 0
Circadian clock R-HSA-9909396 2.130786e-01 0.671 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.347357e-01 0.629 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.057040e-01 0.687 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.261197e-01 0.646 0 0
HSF1-dependent transactivation R-HSA-3371571 2.380608e-01 0.623 0 0
Signaling by NOTCH3 R-HSA-9012852 4.698148e-01 0.328 0 0
Post NMDA receptor activation events R-HSA-438064 1.750576e-01 0.757 0 0
L1CAM interactions R-HSA-373760 3.079343e-01 0.512 0 0
PTEN Regulation R-HSA-6807070 1.713540e-01 0.766 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 4.289726e-01 0.368 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 3.888951e-01 0.410 0 0
Nuclear RNA decay R-HSA-9930044 3.732038e-01 0.428 0 0
Integration of energy metabolism R-HSA-163685 3.558925e-01 0.449 0 0
PLC beta mediated events R-HSA-112043 1.937733e-01 0.713 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.467283e-01 0.608 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.645431e-01 0.333 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.645431e-01 0.333 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.899729e-01 0.310 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.899729e-01 0.310 0 0
Calmodulin induced events R-HSA-111933 2.229148e-01 0.652 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.895300e-01 0.310 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.288330e-01 0.483 0 0
Signal transduction by L1 R-HSA-445144 4.083990e-01 0.389 0 0
CaM pathway R-HSA-111997 2.229148e-01 0.652 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.464558e-01 0.350 0 0
ESR-mediated signaling R-HSA-8939211 4.717612e-01 0.326 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 2.007532e-01 0.697 0 0
Dopamine receptors R-HSA-390651 2.854834e-01 0.544 0 0
Reelin signalling pathway R-HSA-8866376 3.244216e-01 0.489 0 0
Pentose phosphate pathway disease R-HSA-6791465 3.612401e-01 0.442 0 0
Synthesis of PS R-HSA-1483101 3.612401e-01 0.442 0 0
Phosphorylation of Emi1 R-HSA-176417 3.612401e-01 0.442 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.466705e-01 0.608 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.884956e-01 0.725 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.289726e-01 0.368 0 0
Cysteine formation from homocysteine R-HSA-1614603 4.289726e-01 0.368 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.792327e-01 0.747 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.600987e-01 0.337 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.600987e-01 0.337 0 0
Sodium/Proton exchangers R-HSA-425986 4.600987e-01 0.337 0 0
Activation of RAS in B cells R-HSA-1169092 4.600987e-01 0.337 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.974645e-01 0.527 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.937733e-01 0.713 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.691104e-01 0.433 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.888951e-01 0.410 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.895300e-01 0.310 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.895300e-01 0.310 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.464558e-01 0.350 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.600745e-01 0.585 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.751650e-01 0.757 0 0
Mitotic Anaphase R-HSA-68882 2.549161e-01 0.594 0 0
DAG and IP3 signaling R-HSA-1489509 3.457585e-01 0.461 0 0
G-protein mediated events R-HSA-112040 2.467283e-01 0.608 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.833137e-01 0.548 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.515444e-01 0.599 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.271251e-01 0.644 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.021695e-01 0.520 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.042080e-01 0.297 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.289951e-01 0.368 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.457585e-01 0.461 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.229148e-01 0.652 0 0
Gastrulation R-HSA-9758941 4.594217e-01 0.338 0 0
HIV Infection R-HSA-162906 2.286010e-01 0.641 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.678433e-01 0.572 0 0
Cell junction organization R-HSA-446728 1.718058e-01 0.765 0 0
Oncogene Induced Senescence R-HSA-2559585 4.179822e-01 0.379 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 2.466705e-01 0.608 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.347357e-01 0.629 0 0
Mitochondrial biogenesis R-HSA-1592230 3.155357e-01 0.501 0 0
Ion homeostasis R-HSA-5578775 2.905225e-01 0.537 0 0
Autophagy R-HSA-9612973 1.839450e-01 0.735 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.352568e-01 0.628 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.913076e-01 0.407 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.913076e-01 0.407 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.854834e-01 0.544 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.289726e-01 0.368 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.289726e-01 0.368 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.600987e-01 0.337 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.936324e-01 0.532 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.649639e-01 0.333 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.751921e-01 0.323 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.022884e-01 0.694 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 1.690939e-01 0.772 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.974645e-01 0.527 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.895300e-01 0.310 0 0
Separation of Sister Chromatids R-HSA-2467813 3.250283e-01 0.488 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.372551e-01 0.359 0 0
Macroautophagy R-HSA-1632852 1.817163e-01 0.741 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.084194e-01 0.511 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.435243e-01 0.353 0 0
Muscle contraction R-HSA-397014 3.236447e-01 0.490 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.899729e-01 0.310 0 0
Diseases of Immune System R-HSA-5260271 4.899729e-01 0.310 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.801759e-01 0.744 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.008862e-01 0.697 0 0
Ub-specific processing proteases R-HSA-5689880 3.913076e-01 0.407 0 0
Deubiquitination R-HSA-5688426 4.735702e-01 0.325 0 0
DSCAM interactions R-HSA-376172 2.007532e-01 0.697 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.443036e-01 0.612 0 0
Sensory perception of sour taste R-HSA-9729555 2.854834e-01 0.544 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.878842e-01 0.541 0 0
VLDL clearance R-HSA-8964046 4.289726e-01 0.368 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 4.289726e-01 0.368 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.600987e-01 0.337 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.691104e-01 0.433 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.277995e-01 0.484 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.888951e-01 0.410 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.888951e-01 0.410 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.895300e-01 0.310 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.732038e-01 0.428 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.338231e-01 0.476 0 0
RAF activation R-HSA-5673000 4.031571e-01 0.395 0 0
Leishmania phagocytosis R-HSA-9664417 2.692278e-01 0.570 0 0
Parasite infection R-HSA-9664407 2.692278e-01 0.570 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.692278e-01 0.570 0 0
Cellular responses to stress R-HSA-2262752 4.758944e-01 0.322 0 0
RMTs methylate histone arginines R-HSA-3214858 3.331969e-01 0.477 0 0
Reproduction R-HSA-1474165 3.052298e-01 0.515 0 0
RUNX2 regulates bone development R-HSA-8941326 2.229148e-01 0.652 0 0
Smooth Muscle Contraction R-HSA-445355 4.455018e-01 0.351 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.900130e-01 0.538 0 0
Cellular responses to stimuli R-HSA-8953897 3.829262e-01 0.417 0 0
Mitophagy R-HSA-5205647 4.031571e-01 0.395 0 0
Selective autophagy R-HSA-9663891 3.032647e-01 0.518 0 0
Cardiac conduction R-HSA-5576891 4.402444e-01 0.356 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.905225e-01 0.537 0 0
Basigin interactions R-HSA-210991 1.801759e-01 0.744 0 0
Carnitine shuttle R-HSA-200425 4.831007e-01 0.316 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.676133e-01 0.330 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.022884e-01 0.694 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.779891e-01 0.556 0 0
Non-canonical inflammasome activation R-HSA-9686114 2.672812e-01 0.573 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.710077e-01 0.567 0 0
Generation of second messenger molecules R-HSA-202433 2.710077e-01 0.567 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.429820e-01 0.614 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.960541e-01 0.402 0 0
tRNA processing in the nucleus R-HSA-6784531 2.022884e-01 0.694 0 0
Rap1 signalling R-HSA-392517 3.888951e-01 0.410 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.732038e-01 0.428 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.774269e-01 0.751 0 0
Diseases of programmed cell death R-HSA-9645723 3.032647e-01 0.518 0 0
Signaling by ERBB4 R-HSA-1236394 1.805952e-01 0.743 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.520449e-01 0.345 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.581121e-01 0.446 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 2.007532e-01 0.697 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.443036e-01 0.612 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.443036e-01 0.612 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.854834e-01 0.544 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.244216e-01 0.489 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.057040e-01 0.687 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.612401e-01 0.442 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.466705e-01 0.608 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.466705e-01 0.608 0 0
NADPH regeneration R-HSA-389542 3.960541e-01 0.402 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.960541e-01 0.402 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.084194e-01 0.511 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.084194e-01 0.511 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.289726e-01 0.368 0 0
Adrenoceptors R-HSA-390696 4.600987e-01 0.337 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.895300e-01 0.310 0 0
Negative regulation of MET activity R-HSA-6807004 4.083990e-01 0.389 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.759042e-01 0.322 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 4.138030e-01 0.383 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.814504e-01 0.317 0 0
FOXO-mediated transcription R-HSA-9614085 1.692025e-01 0.772 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.231765e-01 0.491 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.016827e-01 0.396 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 4.289726e-01 0.368 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.649639e-01 0.333 0 0
Formation of the nephric duct R-HSA-9830364 2.523599e-01 0.598 0 0
FasL/ CD95L signaling R-HSA-75157 2.443036e-01 0.612 0 0
OAS antiviral response R-HSA-8983711 2.261197e-01 0.646 0 0
Signal regulatory protein family interactions R-HSA-391160 2.672812e-01 0.573 0 0
Leukotriene receptors R-HSA-391906 3.960541e-01 0.402 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.289726e-01 0.368 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.886394e-01 0.724 0 0
Interleukin-1 processing R-HSA-448706 4.895300e-01 0.310 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.895300e-01 0.310 0 0
LDL clearance R-HSA-8964038 4.649639e-01 0.333 0 0
Inositol phosphate metabolism R-HSA-1483249 3.931767e-01 0.405 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.764372e-01 0.424 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.764372e-01 0.424 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.348685e-01 0.475 0 0
Glucose metabolism R-HSA-70326 2.045982e-01 0.689 0 0
TRAIL signaling R-HSA-75158 3.612401e-01 0.442 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.997778e-01 0.699 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.895300e-01 0.310 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.464558e-01 0.350 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.430601e-01 0.354 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.464558e-01 0.350 0 0
Influenza Infection R-HSA-168255 4.316435e-01 0.365 0 0
Signaling by FGFR in disease R-HSA-1226099 1.805952e-01 0.743 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.288330e-01 0.483 0 0
TRP channels R-HSA-3295583 2.673056e-01 0.573 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.600987e-01 0.337 0 0
Tie2 Signaling R-HSA-210993 3.691104e-01 0.433 0 0
Maturation of nucleoprotein R-HSA-9694631 3.888951e-01 0.410 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.732038e-01 0.428 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.464558e-01 0.350 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.375420e-01 0.624 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.084194e-01 0.511 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.289726e-01 0.368 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.905225e-01 0.537 0 0
Gene Silencing by RNA R-HSA-211000 3.514279e-01 0.454 0 0
Nephron development R-HSA-9831926 3.691104e-01 0.433 0 0
Specification of primordial germ cells R-HSA-9827857 3.490774e-01 0.457 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.910245e-01 0.309 0 0
Response to metal ions R-HSA-5660526 3.288330e-01 0.483 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.404064e-01 0.356 0 0
IRE1alpha activates chaperones R-HSA-381070 4.982078e-01 0.303 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.031571e-01 0.395 0 0
Signaling by NOTCH1 R-HSA-1980143 5.066951e-01 0.295 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.084759e-01 0.294 0 0
Stimuli-sensing channels R-HSA-2672351 5.084759e-01 0.294 0 0
Host Interactions of HIV factors R-HSA-162909 5.092099e-01 0.293 0 0
Signaling by WNT R-HSA-195721 5.144906e-01 0.289 0 0
2-LTR circle formation R-HSA-164843 5.173586e-01 0.286 0 0
Regulation of CDH11 function R-HSA-9762292 5.173586e-01 0.286 0 0
PI3K/AKT activation R-HSA-198203 5.173586e-01 0.286 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.173586e-01 0.286 0 0
CASP4 inflammasome assembly R-HSA-9948001 5.173586e-01 0.286 0 0
Signal attenuation R-HSA-74749 5.173586e-01 0.286 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.173586e-01 0.286 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.173586e-01 0.286 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.173586e-01 0.286 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.173586e-01 0.286 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.173586e-01 0.286 0 0
Signaling by Leptin R-HSA-2586552 5.173586e-01 0.286 0 0
Formation of apoptosome R-HSA-111458 5.173586e-01 0.286 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.175374e-01 0.286 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.175374e-01 0.286 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.181853e-01 0.286 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.182051e-01 0.285 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.182051e-01 0.285 0 0
Long-term potentiation R-HSA-9620244 5.182051e-01 0.285 0 0
Tight junction interactions R-HSA-420029 5.182051e-01 0.285 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.182051e-01 0.285 0 0
Interleukin-7 signaling R-HSA-1266695 5.182051e-01 0.285 0 0
Leishmania infection R-HSA-9658195 5.195496e-01 0.284 0 0
Parasitic Infection Pathways R-HSA-9824443 5.195496e-01 0.284 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.247515e-01 0.280 0 0
Kinesins R-HSA-983189 5.287001e-01 0.277 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.310148e-01 0.275 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.351515e-01 0.272 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.351515e-01 0.272 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.351515e-01 0.272 0 0
Myogenesis R-HSA-525793 5.351515e-01 0.272 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.351515e-01 0.272 0 0
Metalloprotease DUBs R-HSA-5689901 5.351515e-01 0.272 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.355778e-01 0.271 0 0
Aquaporin-mediated transport R-HSA-445717 5.400944e-01 0.268 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.436717e-01 0.265 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.436717e-01 0.265 0 0
vRNP Assembly R-HSA-192905 5.436717e-01 0.265 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.436717e-01 0.265 0 0
Bicarbonate transporters R-HSA-425381 5.436717e-01 0.265 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.436717e-01 0.265 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 5.436717e-01 0.265 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.447368e-01 0.264 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.474621e-01 0.262 0 0
PKR-mediated signaling R-HSA-9833482 5.474621e-01 0.262 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.513468e-01 0.259 0 0
Signaling by PDGF R-HSA-186797 5.513468e-01 0.259 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.516838e-01 0.258 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.516838e-01 0.258 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.516838e-01 0.258 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.516838e-01 0.258 0 0
Cell-cell junction organization R-HSA-421270 5.536728e-01 0.257 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.538152e-01 0.257 0 0
G1 Phase R-HSA-69236 5.573210e-01 0.254 0 0
Cyclin D associated events in G1 R-HSA-69231 5.573210e-01 0.254 0 0
Signaling by PTK6 R-HSA-8848021 5.624523e-01 0.250 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.624523e-01 0.250 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.677966e-01 0.246 0 0
Telomere Extension By Telomerase R-HSA-171319 5.677966e-01 0.246 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.677966e-01 0.246 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.685517e-01 0.245 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.685517e-01 0.245 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.685517e-01 0.245 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.685517e-01 0.245 0 0
NF-kB is activated and signals survival R-HSA-209560 5.685517e-01 0.245 0 0
ERKs are inactivated R-HSA-202670 5.685517e-01 0.245 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.685517e-01 0.245 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.685517e-01 0.245 0 0
Integration of provirus R-HSA-162592 5.685517e-01 0.245 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.685517e-01 0.245 0 0
Nucleosome assembly R-HSA-774815 5.701369e-01 0.244 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.701369e-01 0.244 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.701369e-01 0.244 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.701369e-01 0.244 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.701369e-01 0.244 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.701369e-01 0.244 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.701369e-01 0.244 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.734060e-01 0.242 0 0
Adherens junctions interactions R-HSA-418990 5.738859e-01 0.241 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.827207e-01 0.235 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.827207e-01 0.235 0 0
Signaling by TGFBR3 R-HSA-9839373 5.827207e-01 0.235 0 0
mRNA Capping R-HSA-72086 5.834867e-01 0.234 0 0
Glucagon-type ligand receptors R-HSA-420092 5.834867e-01 0.234 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.920767e-01 0.228 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.920767e-01 0.228 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.920767e-01 0.228 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.920767e-01 0.228 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.920767e-01 0.228 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.920767e-01 0.228 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.920767e-01 0.228 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.920767e-01 0.228 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.920767e-01 0.228 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.920767e-01 0.228 0 0
MET activates RAS signaling R-HSA-8851805 5.920767e-01 0.228 0 0
Signaling by LTK R-HSA-9842663 5.920767e-01 0.228 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.920767e-01 0.228 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.920767e-01 0.228 0 0
Estrogen biosynthesis R-HSA-193144 5.920767e-01 0.228 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.920767e-01 0.228 0 0
Recycling pathway of L1 R-HSA-437239 5.950680e-01 0.225 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.950680e-01 0.225 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.950680e-01 0.225 0 0
Potential therapeutics for SARS R-HSA-9679191 5.979912e-01 0.223 0 0
DAP12 signaling R-HSA-2424491 5.987522e-01 0.223 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.987522e-01 0.223 0 0
PI Metabolism R-HSA-1483255 6.064209e-01 0.217 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.064209e-01 0.217 0 0
GPER1 signaling R-HSA-9634597 6.071750e-01 0.217 0 0
NGF-stimulated transcription R-HSA-9031628 6.071750e-01 0.217 0 0
Co-stimulation by CD28 R-HSA-389356 6.071750e-01 0.217 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.100818e-01 0.215 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.135927e-01 0.212 0 0
Budding and maturation of HIV virion R-HSA-162588 6.135927e-01 0.212 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.135927e-01 0.212 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.143203e-01 0.212 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.143203e-01 0.212 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.143203e-01 0.212 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.143203e-01 0.212 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.143203e-01 0.212 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.143203e-01 0.212 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 6.143203e-01 0.212 0 0
Maturation of nucleoprotein R-HSA-9683610 6.143203e-01 0.212 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.143203e-01 0.212 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.157945e-01 0.211 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.157945e-01 0.211 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.157945e-01 0.211 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.190386e-01 0.208 0 0
Cilium Assembly R-HSA-5617833 6.225493e-01 0.206 0 0
Opioid Signalling R-HSA-111885 6.231826e-01 0.205 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.243905e-01 0.205 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.257621e-01 0.204 0 0
Signaling by WNT in cancer R-HSA-4791275 6.280092e-01 0.202 0 0
Toll-like Receptor Cascades R-HSA-168898 6.287075e-01 0.202 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.306565e-01 0.200 0 0
Peptide chain elongation R-HSA-156902 6.326974e-01 0.199 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 6.353522e-01 0.197 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.353522e-01 0.197 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.353522e-01 0.197 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.353522e-01 0.197 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.353522e-01 0.197 0 0
Hydrolysis of LPC R-HSA-1483115 6.353522e-01 0.197 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.353522e-01 0.197 0 0
cGMP effects R-HSA-418457 6.353522e-01 0.197 0 0
Physiological factors R-HSA-5578768 6.353522e-01 0.197 0 0
HDL assembly R-HSA-8963896 6.353522e-01 0.197 0 0
Acyl chain remodeling of CL R-HSA-1482798 6.353522e-01 0.197 0 0
Zinc transporters R-HSA-435354 6.353522e-01 0.197 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.353522e-01 0.197 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.353522e-01 0.197 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.357291e-01 0.197 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.357291e-01 0.197 0 0
COPII-mediated vesicle transport R-HSA-204005 6.357291e-01 0.197 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.386959e-01 0.195 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.386959e-01 0.195 0 0
Nucleotide Excision Repair R-HSA-5696398 6.395285e-01 0.194 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.420038e-01 0.192 0 0
Meiotic recombination R-HSA-912446 6.420267e-01 0.192 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.455224e-01 0.190 0 0
Cellular response to starvation R-HSA-9711097 6.522114e-01 0.186 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 6.531480e-01 0.185 0 0
Neurexins and neuroligins R-HSA-6794361 6.531480e-01 0.185 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.531480e-01 0.185 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.546712e-01 0.184 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.551404e-01 0.184 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.551404e-01 0.184 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.552384e-01 0.184 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.552384e-01 0.184 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.552384e-01 0.184 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.552384e-01 0.184 0 0
p38MAPK events R-HSA-171007 6.552384e-01 0.184 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.552384e-01 0.184 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 6.552384e-01 0.184 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.552384e-01 0.184 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.552384e-01 0.184 0 0
p75NTR signals via NF-kB R-HSA-193639 6.552384e-01 0.184 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.552384e-01 0.184 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.552384e-01 0.184 0 0
Erythropoietin activates RAS R-HSA-9027284 6.552384e-01 0.184 0 0
Protein methylation R-HSA-8876725 6.552384e-01 0.184 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.552384e-01 0.184 0 0
DNA Damage Reversal R-HSA-73942 6.552384e-01 0.184 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.554450e-01 0.183 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.555796e-01 0.183 0 0
Acyl chain remodelling of PC R-HSA-1482788 6.555796e-01 0.183 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.555796e-01 0.183 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.555796e-01 0.183 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.555796e-01 0.183 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.588239e-01 0.181 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.588239e-01 0.181 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.640197e-01 0.178 0 0
Ca2+ pathway R-HSA-4086398 6.645818e-01 0.177 0 0
Signaling by NOTCH2 R-HSA-1980145 6.687407e-01 0.175 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.687407e-01 0.175 0 0
Signal amplification R-HSA-392518 6.687407e-01 0.175 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 6.687407e-01 0.175 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.687407e-01 0.175 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.687407e-01 0.175 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.728276e-01 0.172 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.740412e-01 0.171 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.740412e-01 0.171 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.740412e-01 0.171 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.740412e-01 0.171 0 0
Phosphorylation of the APC/C R-HSA-176412 6.740412e-01 0.171 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.740412e-01 0.171 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.740412e-01 0.171 0 0
Differentiation of T cells R-HSA-9945266 6.740412e-01 0.171 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.740412e-01 0.171 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.740412e-01 0.171 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.755616e-01 0.170 0 0
TCR signaling R-HSA-202403 6.784908e-01 0.168 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.812568e-01 0.167 0 0
Acyl chain remodelling of PE R-HSA-1482839 6.814919e-01 0.167 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.814919e-01 0.167 0 0
Co-inhibition by PD-1 R-HSA-389948 6.816960e-01 0.166 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.829303e-01 0.166 0 0
G alpha (z) signalling events R-HSA-418597 6.850138e-01 0.164 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.889455e-01 0.162 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.918197e-01 0.160 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.918197e-01 0.160 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 6.918197e-01 0.160 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.918197e-01 0.160 0 0
Passive transport by Aquaporins R-HSA-432047 6.918197e-01 0.160 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.918197e-01 0.160 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.918197e-01 0.160 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.938388e-01 0.159 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.938388e-01 0.159 0 0
Glycosphingolipid transport R-HSA-9845576 6.938388e-01 0.159 0 0
FGFR2 mutant receptor activation R-HSA-1839126 6.938388e-01 0.159 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.996269e-01 0.155 0 0
IRS-mediated signalling R-HSA-112399 7.050123e-01 0.152 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.057875e-01 0.151 0 0
Degradation of DVL R-HSA-4641258 7.057875e-01 0.151 0 0
Collagen chain trimerization R-HSA-8948216 7.057875e-01 0.151 0 0
Eukaryotic Translation Termination R-HSA-72764 7.073686e-01 0.150 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.086295e-01 0.150 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.086295e-01 0.150 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.086295e-01 0.150 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.086295e-01 0.150 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.086295e-01 0.150 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.086295e-01 0.150 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.086295e-01 0.150 0 0
Catecholamine biosynthesis R-HSA-209905 7.086295e-01 0.150 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.086295e-01 0.150 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.086295e-01 0.150 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.086295e-01 0.150 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.086295e-01 0.150 0 0
PCP/CE pathway R-HSA-4086400 7.091099e-01 0.149 0 0
Signaling by NTRKs R-HSA-166520 7.111748e-01 0.148 0 0
Dual incision in TC-NER R-HSA-6782135 7.146410e-01 0.146 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.173448e-01 0.144 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.215076e-01 0.142 0 0
Amino acid transport across the plasma membrane R-HSA-352230 7.240249e-01 0.140 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.245233e-01 0.140 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.245233e-01 0.140 0 0
Chaperone Mediated Autophagy R-HSA-9613829 7.245233e-01 0.140 0 0
PKA activation R-HSA-163615 7.245233e-01 0.140 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.245233e-01 0.140 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.245233e-01 0.140 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.245233e-01 0.140 0 0
Mismatch Repair R-HSA-5358508 7.245233e-01 0.140 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 7.245233e-01 0.140 0 0
Platelet sensitization by LDL R-HSA-432142 7.245233e-01 0.140 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.245233e-01 0.140 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.245233e-01 0.140 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.245233e-01 0.140 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.256673e-01 0.139 0 0
Ion channel transport R-HSA-983712 7.274266e-01 0.138 0 0
Stabilization of p53 R-HSA-69541 7.285177e-01 0.138 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.285177e-01 0.138 0 0
Signaling by ALK R-HSA-201556 7.285177e-01 0.138 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.297492e-01 0.137 0 0
Regulation of insulin secretion R-HSA-422356 7.297492e-01 0.137 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.297492e-01 0.137 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.297492e-01 0.137 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.297492e-01 0.137 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.326452e-01 0.135 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.331661e-01 0.135 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.331661e-01 0.135 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.331661e-01 0.135 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.331661e-01 0.135 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.331661e-01 0.135 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.331661e-01 0.135 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.331661e-01 0.135 0 0
Interleukin-1 family signaling R-HSA-446652 7.350385e-01 0.134 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.393137e-01 0.131 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.393137e-01 0.131 0 0
Aggrephagy R-HSA-9646399 7.393137e-01 0.131 0 0
Attenuation phase R-HSA-3371568 7.393137e-01 0.131 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.395511e-01 0.131 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.395511e-01 0.131 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.420668e-01 0.130 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.420668e-01 0.130 0 0
Collagen degradation R-HSA-1442490 7.420668e-01 0.130 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.491708e-01 0.125 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.497408e-01 0.125 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.497408e-01 0.125 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.497865e-01 0.125 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.507298e-01 0.125 0 0
Selenocysteine synthesis R-HSA-2408557 7.508659e-01 0.124 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.537599e-01 0.123 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.537599e-01 0.123 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.537599e-01 0.123 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.537599e-01 0.123 0 0
Signaling by NODAL R-HSA-1181150 7.537599e-01 0.123 0 0
Acyl chain remodelling of PI R-HSA-1482922 7.537599e-01 0.123 0 0
Formation of definitive endoderm R-HSA-9823730 7.537599e-01 0.123 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.537599e-01 0.123 0 0
Protein hydroxylation R-HSA-9629569 7.537599e-01 0.123 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.537599e-01 0.123 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.566538e-01 0.121 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.566538e-01 0.121 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.575707e-01 0.121 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.591578e-01 0.120 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.598070e-01 0.119 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.598070e-01 0.119 0 0
HIV Transcription Initiation R-HSA-167161 7.598070e-01 0.119 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.598070e-01 0.119 0 0
Intra-Golgi traffic R-HSA-6811438 7.598070e-01 0.119 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.598070e-01 0.119 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.598070e-01 0.119 0 0
HCMV Late Events R-HSA-9610379 7.629228e-01 0.118 0 0
HCMV Early Events R-HSA-9609690 7.631201e-01 0.117 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.639632e-01 0.117 0 0
Signaling by Hedgehog R-HSA-5358351 7.640331e-01 0.117 0 0
Viral mRNA Translation R-HSA-192823 7.642471e-01 0.117 0 0
Chromosome Maintenance R-HSA-73886 7.664238e-01 0.116 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.671944e-01 0.115 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.671944e-01 0.115 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 7.671944e-01 0.115 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.671944e-01 0.115 0 0
Signalling to RAS R-HSA-167044 7.671944e-01 0.115 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.671944e-01 0.115 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.671944e-01 0.115 0 0
ERK/MAPK targets R-HSA-198753 7.671944e-01 0.115 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 7.671944e-01 0.115 0 0
Acyl chain remodelling of PG R-HSA-1482925 7.671944e-01 0.115 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.671944e-01 0.115 0 0
IGF1R signaling cascade R-HSA-2428924 7.673538e-01 0.115 0 0
Insulin receptor signalling cascade R-HSA-74751 7.673538e-01 0.115 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.695207e-01 0.114 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.695207e-01 0.114 0 0
Depyrimidination R-HSA-73928 7.695207e-01 0.114 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.696477e-01 0.114 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.707308e-01 0.113 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.753212e-01 0.111 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.753212e-01 0.111 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.782195e-01 0.109 0 0
Signaling by TGFB family members R-HSA-9006936 7.786158e-01 0.109 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.788904e-01 0.109 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.788904e-01 0.109 0 0
Signaling by SCF-KIT R-HSA-1433557 7.788904e-01 0.109 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.798967e-01 0.108 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.798967e-01 0.108 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.798967e-01 0.108 0 0
Assembly Of The HIV Virion R-HSA-175474 7.798967e-01 0.108 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.848652e-01 0.105 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.879246e-01 0.104 0 0
DAP12 interactions R-HSA-2172127 7.879246e-01 0.104 0 0
Amine ligand-binding receptors R-HSA-375280 7.879246e-01 0.104 0 0
Platelet homeostasis R-HSA-418346 7.893653e-01 0.103 0 0
SLC-mediated transport of amino acids R-HSA-9958863 7.905837e-01 0.102 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.919067e-01 0.101 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.919067e-01 0.101 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.919067e-01 0.101 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.919067e-01 0.101 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.919067e-01 0.101 0 0
Signaling by KIT in disease R-HSA-9669938 7.919067e-01 0.101 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.919067e-01 0.101 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.966320e-01 0.099 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.966320e-01 0.099 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.966320e-01 0.099 0 0
Adaptive Immune System R-HSA-1280218 7.976948e-01 0.098 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.978860e-01 0.098 0 0
ER-Phagosome pathway R-HSA-1236974 7.979627e-01 0.098 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.011189e-01 0.096 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.011189e-01 0.096 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.032620e-01 0.095 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.032620e-01 0.095 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.032620e-01 0.095 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.032620e-01 0.095 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.032620e-01 0.095 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.032620e-01 0.095 0 0
Organic anion transport by SLCO transporters R-HSA-879518 8.032620e-01 0.095 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 8.032620e-01 0.095 0 0
Growth hormone receptor signaling R-HSA-982772 8.032620e-01 0.095 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.050215e-01 0.094 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.067987e-01 0.093 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 8.118519e-01 0.091 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.139983e-01 0.089 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.139983e-01 0.089 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.139983e-01 0.089 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.139983e-01 0.089 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.139983e-01 0.089 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.139983e-01 0.089 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.139983e-01 0.089 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.139983e-01 0.089 0 0
Interleukin-6 family signaling R-HSA-6783589 8.139983e-01 0.089 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.139983e-01 0.089 0 0
Hedgehog 'on' state R-HSA-5632684 8.185233e-01 0.087 0 0
S Phase R-HSA-69242 8.204677e-01 0.086 0 0
Metal ion SLC transporters R-HSA-425410 8.208814e-01 0.086 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.208814e-01 0.086 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.209271e-01 0.086 0 0
Signaling by Insulin receptor R-HSA-74752 8.222224e-01 0.085 0 0
Protein folding R-HSA-391251 8.222224e-01 0.085 0 0
Alpha-oxidation of phytanate R-HSA-389599 8.241493e-01 0.084 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.241493e-01 0.084 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.241493e-01 0.084 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.241493e-01 0.084 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.282376e-01 0.082 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.282376e-01 0.082 0 0
Degradation of CDH1 R-HSA-9766229 8.283693e-01 0.082 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.334213e-01 0.079 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.337470e-01 0.079 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.337470e-01 0.079 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.337470e-01 0.079 0 0
Sphingolipid catabolism R-HSA-9845614 8.337470e-01 0.079 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.337850e-01 0.079 0 0
rRNA processing R-HSA-72312 8.339343e-01 0.079 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.355741e-01 0.078 0 0
PI3K Cascade R-HSA-109704 8.355741e-01 0.078 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.382108e-01 0.077 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.425044e-01 0.074 0 0
Packaging Of Telomere Ends R-HSA-171306 8.428213e-01 0.074 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.428213e-01 0.074 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.428213e-01 0.074 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.428213e-01 0.074 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 8.428213e-01 0.074 0 0
Insulin processing R-HSA-264876 8.428213e-01 0.074 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.428213e-01 0.074 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.430167e-01 0.074 0 0
Protein ubiquitination R-HSA-8852135 8.432281e-01 0.074 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.440255e-01 0.074 0 0
Interleukin-12 signaling R-HSA-9020591 8.489299e-01 0.071 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.491111e-01 0.071 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.491686e-01 0.071 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.491686e-01 0.071 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.491686e-01 0.071 0 0
Insulin receptor recycling R-HSA-77387 8.514009e-01 0.070 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.514009e-01 0.070 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.514009e-01 0.070 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.514009e-01 0.070 0 0
Telomere Maintenance R-HSA-157579 8.540557e-01 0.069 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.555752e-01 0.068 0 0
DNA methylation R-HSA-5334118 8.595127e-01 0.066 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.595127e-01 0.066 0 0
DARPP-32 events R-HSA-180024 8.595127e-01 0.066 0 0
Late endosomal microautophagy R-HSA-9615710 8.595127e-01 0.066 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.595127e-01 0.066 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.595127e-01 0.066 0 0
Platelet calcium homeostasis R-HSA-418360 8.595127e-01 0.066 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.595127e-01 0.066 0 0
Signaling by Erythropoietin R-HSA-9006335 8.595127e-01 0.066 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.597940e-01 0.066 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.608958e-01 0.065 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.617324e-01 0.065 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.617324e-01 0.065 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.620941e-01 0.064 0 0
Synthesis of bile acids and bile salts R-HSA-192105 8.635327e-01 0.064 0 0
Transmission across Chemical Synapses R-HSA-112315 8.635948e-01 0.064 0 0
Interferon Signaling R-HSA-913531 8.646125e-01 0.063 0 0
Ribosome-associated quality control R-HSA-9948299 8.648451e-01 0.063 0 0
Activation of BH3-only proteins R-HSA-114452 8.671821e-01 0.062 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.671821e-01 0.062 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.671821e-01 0.062 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.671821e-01 0.062 0 0
Neurotransmitter clearance R-HSA-112311 8.671821e-01 0.062 0 0
Signaling by FGFR2 R-HSA-5654738 8.699669e-01 0.060 0 0
Signaling by MET R-HSA-6806834 8.699669e-01 0.060 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.724780e-01 0.059 0 0
MAPK family signaling cascades R-HSA-5683057 8.731560e-01 0.059 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.733309e-01 0.059 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.744332e-01 0.058 0 0
Cargo concentration in the ER R-HSA-5694530 8.744332e-01 0.058 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.744332e-01 0.058 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 8.744332e-01 0.058 0 0
Amyloid fiber formation R-HSA-977225 8.748048e-01 0.058 0 0
Regulation of CDH1 Function R-HSA-9764561 8.787880e-01 0.056 0 0
Synthesis of PA R-HSA-1483166 8.787880e-01 0.056 0 0
MHC class II antigen presentation R-HSA-2132295 8.811700e-01 0.055 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.812890e-01 0.055 0 0
DAG1 glycosylations R-HSA-8931838 8.812890e-01 0.055 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.812890e-01 0.055 0 0
Cellular response to chemical stress R-HSA-9711123 8.816220e-01 0.055 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.821657e-01 0.054 0 0
Selenoamino acid metabolism R-HSA-2408522 8.830460e-01 0.054 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.840041e-01 0.054 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.840273e-01 0.054 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.877707e-01 0.052 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.877707e-01 0.052 0 0
Recycling of bile acids and salts R-HSA-159418 8.877707e-01 0.052 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.877707e-01 0.052 0 0
Cardiogenesis R-HSA-9733709 8.877707e-01 0.052 0 0
RSV-host interactions R-HSA-9833110 8.888594e-01 0.051 0 0
Extension of Telomeres R-HSA-180786 8.890563e-01 0.051 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.890563e-01 0.051 0 0
Regulation of beta-cell development R-HSA-186712 8.890563e-01 0.051 0 0
HCMV Infection R-HSA-9609646 8.894466e-01 0.051 0 0
SARS-CoV Infections R-HSA-9679506 8.903885e-01 0.050 0 0
G1/S Transition R-HSA-69206 8.919943e-01 0.050 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.925959e-01 0.049 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.938990e-01 0.049 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.938990e-01 0.049 0 0
Neutrophil degranulation R-HSA-6798695 8.944595e-01 0.048 0 0
MAP kinase activation R-HSA-450294 8.985125e-01 0.046 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.990351e-01 0.046 0 0
Dual Incision in GG-NER R-HSA-5696400 8.996930e-01 0.046 0 0
eNOS activation R-HSA-203615 8.996930e-01 0.046 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.996930e-01 0.046 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.996930e-01 0.046 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.996930e-01 0.046 0 0
tRNA processing R-HSA-72306 9.040624e-01 0.044 0 0
Interleukin-12 family signaling R-HSA-447115 9.044152e-01 0.044 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.051709e-01 0.043 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.051709e-01 0.043 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.051709e-01 0.043 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.051709e-01 0.043 0 0
Signalling to ERKs R-HSA-187687 9.051709e-01 0.043 0 0
PERK regulates gene expression R-HSA-381042 9.051709e-01 0.043 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.051709e-01 0.043 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.099789e-01 0.041 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.103499e-01 0.041 0 0
HSF1 activation R-HSA-3371511 9.103499e-01 0.041 0 0
Triglyceride catabolism R-HSA-163560 9.103499e-01 0.041 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.103499e-01 0.041 0 0
G1/S-Specific Transcription R-HSA-69205 9.103499e-01 0.041 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.109899e-01 0.040 0 0
Ion transport by P-type ATPases R-HSA-936837 9.112973e-01 0.040 0 0
Metabolism of steroids R-HSA-8957322 9.136875e-01 0.039 0 0
Neurotransmitter release cycle R-HSA-112310 9.150461e-01 0.039 0 0
Base Excision Repair R-HSA-73884 9.150461e-01 0.039 0 0
Cellular response to hypoxia R-HSA-1234174 9.152123e-01 0.038 0 0
Degradation of AXIN R-HSA-4641257 9.152464e-01 0.038 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.152464e-01 0.038 0 0
Cleavage of the damaged purine R-HSA-110331 9.152464e-01 0.038 0 0
NCAM1 interactions R-HSA-419037 9.152464e-01 0.038 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.152464e-01 0.038 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.152464e-01 0.038 0 0
Signaling by NOTCH R-HSA-157118 9.164519e-01 0.038 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.198758e-01 0.036 0 0
Depurination R-HSA-73927 9.198758e-01 0.036 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.209805e-01 0.036 0 0
Neddylation R-HSA-8951664 9.225319e-01 0.035 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.225603e-01 0.035 0 0
RAS processing R-HSA-9648002 9.242525e-01 0.034 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.242525e-01 0.034 0 0
Pentose phosphate pathway R-HSA-71336 9.242525e-01 0.034 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.242525e-01 0.034 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.245898e-01 0.034 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.260053e-01 0.033 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.275461e-01 0.033 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.283904e-01 0.032 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.283904e-01 0.032 0 0
Collagen formation R-HSA-1474290 9.303957e-01 0.031 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.323026e-01 0.030 0 0
FLT3 Signaling R-HSA-9607240 9.323026e-01 0.030 0 0
Interleukin-17 signaling R-HSA-448424 9.324659e-01 0.030 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.354924e-01 0.029 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.354924e-01 0.029 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.354924e-01 0.029 0 0
Metabolism of cofactors R-HSA-8978934 9.354924e-01 0.029 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.360012e-01 0.029 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.360012e-01 0.029 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.360012e-01 0.029 0 0
Translation of Structural Proteins R-HSA-9683701 9.360012e-01 0.029 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.383900e-01 0.028 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.394979e-01 0.027 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.394979e-01 0.027 0 0
Defective pyroptosis R-HSA-9710421 9.428038e-01 0.026 0 0
Signaling by FGFR4 R-HSA-5654743 9.428038e-01 0.026 0 0
Signaling by FGFR R-HSA-190236 9.431567e-01 0.025 0 0
Signaling by NOTCH4 R-HSA-9013694 9.438188e-01 0.025 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.438188e-01 0.025 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.439356e-01 0.025 0 0
Proteasome assembly R-HSA-9907900 9.459293e-01 0.024 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.463595e-01 0.024 0 0
SLC transporter disorders R-HSA-5619102 9.464189e-01 0.024 0 0
Somitogenesis R-HSA-9824272 9.488841e-01 0.023 0 0
Signaling by FGFR3 R-HSA-5654741 9.488841e-01 0.023 0 0
Interleukin-1 signaling R-HSA-9020702 9.497345e-01 0.022 0 0
Translation of Structural Proteins R-HSA-9694635 9.511162e-01 0.022 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.516776e-01 0.022 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.516776e-01 0.022 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.533409e-01 0.021 0 0
Integrin cell surface interactions R-HSA-216083 9.533409e-01 0.021 0 0
Developmental Cell Lineages R-HSA-9734767 9.548128e-01 0.020 0 0
Signaling by Interleukins R-HSA-449147 9.549991e-01 0.020 0 0
G alpha (q) signalling events R-HSA-416476 9.560532e-01 0.020 0 0
Gluconeogenesis R-HSA-70263 9.568155e-01 0.019 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.589099e-01 0.018 0 0
DNA Damage Bypass R-HSA-73893 9.591760e-01 0.018 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.591760e-01 0.018 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.613087e-01 0.017 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.635174e-01 0.016 0 0
Neuronal System R-HSA-112316 9.639203e-01 0.016 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.650354e-01 0.015 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.657896e-01 0.015 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.679618e-01 0.014 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.691801e-01 0.014 0 0
Interferon gamma signaling R-HSA-877300 9.697346e-01 0.013 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.724586e-01 0.012 0 0
Signaling by FGFR1 R-HSA-5654736 9.724586e-01 0.012 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.724586e-01 0.012 0 0
Downstream TCR signaling R-HSA-202424 9.747404e-01 0.011 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.747404e-01 0.011 0 0
Peroxisomal protein import R-HSA-9033241 9.767348e-01 0.010 0 0
Triglyceride metabolism R-HSA-8979227 9.767348e-01 0.010 0 0
Peptide hormone metabolism R-HSA-2980736 9.774453e-01 0.010 0 0
tRNA Aminoacylation R-HSA-379724 9.780073e-01 0.010 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.781185e-01 0.010 0 0
Endogenous sterols R-HSA-211976 9.792103e-01 0.009 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.792103e-01 0.009 0 0
Mitochondrial protein degradation R-HSA-9837999 9.801230e-01 0.009 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.803476e-01 0.009 0 0
G alpha (s) signalling events R-HSA-418555 9.813095e-01 0.008 0 0
Phospholipid metabolism R-HSA-1483257 9.822157e-01 0.008 0 0
Mitochondrial translation elongation R-HSA-5389840 9.827999e-01 0.008 0 0
Formation of the cornified envelope R-HSA-6809371 9.833558e-01 0.007 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.843082e-01 0.007 0 0
Mitochondrial translation initiation R-HSA-5368286 9.843864e-01 0.007 0 0
Metabolism of steroid hormones R-HSA-196071 9.851669e-01 0.006 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.857396e-01 0.006 0 0
Post-translational protein modification R-HSA-597592 9.858276e-01 0.006 0 0
O-linked glycosylation of mucins R-HSA-913709 9.859786e-01 0.006 0 0
Platelet degranulation R-HSA-114608 9.860347e-01 0.006 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.874714e-01 0.005 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.877554e-01 0.005 0 0
GPCR downstream signalling R-HSA-388396 9.879838e-01 0.005 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.881571e-01 0.005 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.894182e-01 0.005 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.894182e-01 0.005 0 0
Translation R-HSA-72766 9.896043e-01 0.005 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.897583e-01 0.004 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.905451e-01 0.004 0 0
Iron uptake and transport R-HSA-917937 9.905451e-01 0.004 0 0
UCH proteinases R-HSA-5689603 9.910627e-01 0.004 0 0
Mitochondrial translation termination R-HSA-5419276 9.913092e-01 0.004 0 0
Viral Infection Pathways R-HSA-9824446 9.917160e-01 0.004 0 0
ABC transporter disorders R-HSA-5619084 9.920147e-01 0.003 0 0
Cholesterol biosynthesis R-HSA-191273 9.920147e-01 0.003 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.925031e-01 0.003 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.925165e-01 0.003 0 0
Immune System R-HSA-168256 9.939767e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.941459e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.941459e-01 0.003 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.942955e-01 0.002 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.943046e-01 0.002 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.951903e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.951903e-01 0.002 0 0
Protein localization R-HSA-9609507 9.962200e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.968457e-01 0.001 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.969359e-01 0.001 0 0
Signaling by GPCR R-HSA-372790 9.969623e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.972405e-01 0.001 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.972408e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.975546e-01 0.001 0 0
Sensory perception of taste R-HSA-9717189 9.976205e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.980484e-01 0.001 0 0
Sphingolipid metabolism R-HSA-428157 9.983029e-01 0.001 0 0
O-linked glycosylation R-HSA-5173105 9.983295e-01 0.001 0 0
Mitochondrial translation R-HSA-5368287 9.984121e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.984465e-01 0.001 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.985281e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.985783e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.985783e-01 0.001 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.986108e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.987348e-01 0.001 0 0
Synthesis of DNA R-HSA-69239 9.987573e-01 0.001 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.988899e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.990084e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.990178e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.992324e-01 0.000 0 0
DNA Replication R-HSA-69306 9.992977e-01 0.000 0 0
Hemostasis R-HSA-109582 9.993674e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.995502e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.996412e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.997081e-01 0.000 0 0
Keratinization R-HSA-6805567 9.997206e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998261e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.998876e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999084e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999221e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999304e-01 0.000 0 0
Disease R-HSA-1643685 9.999566e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999675e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999702e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999881e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999887e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999893e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999953e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999993e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999995e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999998e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
HSF1-dependent transactivation R-HSA-3371571 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Attenuation phase R-HSA-3371568 2.220446e-16 15.654 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.220446e-16 15.654 0 0
Cell Cycle R-HSA-1640170 5.107026e-15 14.292 0 0
Metabolism of RNA R-HSA-8953854 4.385381e-14 13.358 0 0
M Phase R-HSA-68886 1.672440e-12 11.777 0 0
HSF1 activation R-HSA-3371511 1.847189e-12 11.733 0 0
Cell-Cell communication R-HSA-1500931 2.375766e-12 11.624 0 0
Cell Cycle, Mitotic R-HSA-69278 2.671308e-12 11.573 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.418865e-11 10.466 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.762657e-11 10.425 0 0
Cell Cycle Checkpoints R-HSA-69620 1.627949e-10 9.788 0 0
Axon guidance R-HSA-422475 3.868856e-10 9.412 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.150819e-10 9.288 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.800165e-10 9.056 0 0
Cell junction organization R-HSA-446728 1.111165e-09 8.954 0 0
Apoptotic execution phase R-HSA-75153 1.137741e-09 8.944 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.285570e-09 8.891 0 0
Nervous system development R-HSA-9675108 1.651967e-09 8.782 0 0
ESR-mediated signaling R-HSA-8939211 1.731553e-09 8.762 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.446366e-09 8.611 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.446366e-09 8.611 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.134010e-09 8.290 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.725709e-09 8.242 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.909258e-09 8.228 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.350537e-09 8.197 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 7.481984e-09 8.126 0 0
Mitotic Prometaphase R-HSA-68877 8.244547e-09 8.084 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.058033e-09 8.043 0 0
G2/M Checkpoints R-HSA-69481 8.980303e-09 8.047 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 9.700306e-09 8.013 0 0
Adherens junctions interactions R-HSA-418990 9.921468e-09 8.003 0 0
Interferon Signaling R-HSA-913531 1.127255e-08 7.948 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.372540e-08 7.862 0 0
Translation initiation complex formation R-HSA-72649 1.661075e-08 7.780 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.866176e-08 7.729 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.278085e-08 7.642 0 0
Signaling by ALK in cancer R-HSA-9700206 2.278085e-08 7.642 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.097649e-08 7.387 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.097649e-08 7.387 0 0
Influenza Infection R-HSA-168255 4.022761e-08 7.395 0 0
Mitotic Prophase R-HSA-68875 4.845796e-08 7.315 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.877261e-08 7.231 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.767681e-08 7.170 0 0
Signal Transduction R-HSA-162582 7.409578e-08 7.130 1 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.373849e-08 7.028 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.596086e-08 7.018 0 0
mRNA Splicing R-HSA-72172 1.122599e-07 6.950 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.141622e-07 6.942 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.228883e-07 6.910 0 0
Cell-cell junction organization R-HSA-421270 1.369937e-07 6.863 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.592267e-07 6.798 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.643678e-07 6.784 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.882246e-07 6.725 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.419939e-07 6.616 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.369234e-07 6.625 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.652973e-07 6.576 0 0
Apoptosis R-HSA-109581 2.688632e-07 6.570 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.168930e-07 6.499 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.506606e-07 6.455 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.005154e-07 6.397 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.557951e-07 6.341 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.614287e-07 6.336 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.282214e-07 6.277 0 0
DNA Double Strand Break Response R-HSA-5693606 5.530642e-07 6.257 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.802885e-07 6.236 0 0
Gene Silencing by RNA R-HSA-211000 5.802885e-07 6.236 0 0
Peptide chain elongation R-HSA-156902 6.390279e-07 6.194 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 7.076523e-07 6.150 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.038371e-07 6.153 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.182158e-07 6.144 0 0
Homology Directed Repair R-HSA-5693538 7.346279e-07 6.134 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.966617e-07 6.099 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.156690e-06 5.937 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.238793e-06 5.907 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.401445e-06 5.853 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.548881e-06 5.810 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.560523e-06 5.807 0 0
Post NMDA receptor activation events R-HSA-438064 1.575028e-06 5.803 0 0
Recycling pathway of L1 R-HSA-437239 2.032050e-06 5.692 0 0
Separation of Sister Chromatids R-HSA-2467813 2.070073e-06 5.684 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.126136e-06 5.672 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.130209e-06 5.672 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.299641e-06 5.638 0 0
Signaling by ROBO receptors R-HSA-376176 2.333271e-06 5.632 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.937452e-06 5.532 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.957815e-06 5.529 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.707423e-06 5.431 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.707423e-06 5.431 0 0
Nucleosome assembly R-HSA-774815 4.416724e-06 5.355 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.416724e-06 5.355 0 0
Signaling by Hippo R-HSA-2028269 4.540353e-06 5.343 1 1
Diseases of programmed cell death R-HSA-9645723 5.525288e-06 5.258 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.625543e-06 5.250 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.984842e-06 5.223 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.000871e-06 5.222 0 0
Regulation of TP53 Activity R-HSA-5633007 6.582435e-06 5.182 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.566325e-06 5.183 0 0
Chaperone Mediated Autophagy R-HSA-9613829 7.053628e-06 5.152 0 0
Programmed Cell Death R-HSA-5357801 7.115328e-06 5.148 0 0
Meiotic synapsis R-HSA-1221632 9.094379e-06 5.041 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.094379e-06 5.041 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.810991e-06 5.055 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.012619e-06 5.045 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.420796e-06 5.026 0 0
Eukaryotic Translation Termination R-HSA-72764 9.626691e-06 5.017 0 0
HDACs deacetylate histones R-HSA-3214815 1.433042e-05 4.844 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.783384e-05 4.749 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 1.973509e-05 4.705 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.015344e-05 4.696 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.164418e-05 4.665 0 0
Mitotic Anaphase R-HSA-68882 2.298361e-05 4.639 0 0
L1CAM interactions R-HSA-373760 2.326220e-05 4.633 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.397486e-05 4.620 0 0
mRNA 3'-end processing R-HSA-72187 2.397486e-05 4.620 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.453908e-05 4.610 0 0
Gene expression (Transcription) R-HSA-74160 2.529205e-05 4.597 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.543711e-05 4.595 0 0
rRNA processing R-HSA-72312 2.816042e-05 4.550 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.940602e-05 4.532 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.209128e-05 4.494 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.250703e-05 4.488 0 0
G2/M Transition R-HSA-69275 3.278678e-05 4.484 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.376721e-05 4.472 0 0
Cellular Senescence R-HSA-2559583 3.580240e-05 4.446 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.733333e-05 4.428 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.876146e-05 4.412 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.059412e-05 4.392 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.146061e-05 4.382 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.172756e-05 4.380 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.418683e-05 4.355 0 0
Aggrephagy R-HSA-9646399 4.451886e-05 4.351 0 0
RNA Polymerase I Transcription R-HSA-73864 4.792215e-05 4.319 0 0
Ribosome-associated quality control R-HSA-9948299 4.959780e-05 4.305 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.819516e-05 4.235 0 0
Cellular response to starvation R-HSA-9711097 5.618703e-05 4.250 0 0
Signaling by NOTCH R-HSA-157118 5.978263e-05 4.223 0 0
Deubiquitination R-HSA-5688426 6.334485e-05 4.198 0 0
Selenocysteine synthesis R-HSA-2408557 6.339343e-05 4.198 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.394872e-05 4.194 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.661070e-05 4.176 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.729555e-05 4.172 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.729555e-05 4.172 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 8.300744e-05 4.081 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.122394e-05 4.040 0 0
Viral mRNA Translation R-HSA-192823 8.437841e-05 4.074 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.944701e-05 4.048 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 9.626230e-05 4.017 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.751238e-05 4.011 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.054671e-04 3.977 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.054671e-04 3.977 0 0
Membrane Trafficking R-HSA-199991 1.119959e-04 3.951 0 0
Long-term potentiation R-HSA-9620244 1.208779e-04 3.918 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.208457e-04 3.918 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.211195e-04 3.917 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.259209e-04 3.900 0 0
Signaling by ERBB2 R-HSA-1227986 1.211195e-04 3.917 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.283645e-04 3.892 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.208457e-04 3.918 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.299338e-04 3.886 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.454064e-04 3.837 0 0
Meiosis R-HSA-1500620 1.486168e-04 3.828 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.519540e-04 3.818 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.519540e-04 3.818 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.646695e-04 3.783 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.734099e-04 3.761 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.760222e-04 3.754 0 0
PKR-mediated signaling R-HSA-9833482 1.765351e-04 3.753 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.961041e-04 3.708 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.005251e-04 3.698 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.005251e-04 3.698 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.071206e-04 3.684 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.071206e-04 3.684 0 0
Protein ubiquitination R-HSA-8852135 2.091488e-04 3.680 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.128429e-04 3.672 0 0
Chromosome Maintenance R-HSA-73886 2.392253e-04 3.621 0 0
MAPK family signaling cascades R-HSA-5683057 2.486317e-04 3.604 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.559312e-04 3.592 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.706584e-04 3.568 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.712462e-04 3.567 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.712462e-04 3.567 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.982622e-04 3.525 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.024707e-04 3.519 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.073872e-04 3.512 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.161479e-04 3.500 0 0
SARS-CoV Infections R-HSA-9679506 3.226195e-04 3.491 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.316496e-04 3.479 0 0
Negative regulation of MET activity R-HSA-6807004 3.362040e-04 3.473 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.436480e-04 3.464 0 0
Defective pyroptosis R-HSA-9710421 3.560874e-04 3.448 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.586260e-04 3.445 0 0
DNA methylation R-HSA-5334118 3.586923e-04 3.445 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.959717e-04 3.402 0 0
Autophagy R-HSA-9612973 4.044156e-04 3.393 0 0
Viral Infection Pathways R-HSA-9824446 3.883903e-04 3.411 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.544835e-04 3.342 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.544835e-04 3.342 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.683834e-04 3.329 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.683834e-04 3.329 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.876402e-04 3.312 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.592558e-04 3.252 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.647653e-04 3.248 0 0
DNA Repair R-HSA-73894 5.857585e-04 3.232 0 0
Interleukin-12 signaling R-HSA-9020591 6.165636e-04 3.210 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.345825e-04 3.198 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.345825e-04 3.198 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.345825e-04 3.198 0 0
Signaling by RAS mutants R-HSA-6802949 6.345825e-04 3.198 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.778079e-04 3.169 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.259512e-04 3.139 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.546845e-04 3.184 0 0
HCMV Early Events R-HSA-9609690 6.535091e-04 3.185 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.668587e-04 3.176 0 0
RNA Polymerase II Transcription R-HSA-73857 6.815966e-04 3.166 0 0
Selective autophagy R-HSA-9663891 6.396438e-04 3.194 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.385489e-04 3.195 0 0
Macroautophagy R-HSA-1632852 6.644857e-04 3.178 0 0
Glycolysis R-HSA-70171 7.186611e-04 3.143 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.259512e-04 3.139 0 0
Chromatin organization R-HSA-4839726 7.713653e-04 3.113 0 0
Chromatin modifying enzymes R-HSA-3247509 7.716956e-04 3.113 0 0
Packaging Of Telomere Ends R-HSA-171306 7.779960e-04 3.109 0 0
mTORC1-mediated signalling R-HSA-166208 7.955278e-04 3.099 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.541771e-04 3.068 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.541771e-04 3.068 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.541771e-04 3.068 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.541771e-04 3.068 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.541771e-04 3.068 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.541771e-04 3.068 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.541771e-04 3.068 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.541771e-04 3.068 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.541771e-04 3.068 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.541771e-04 3.068 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.541771e-04 3.068 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 8.556509e-04 3.068 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 8.803491e-04 3.055 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.803491e-04 3.055 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.841071e-04 3.053 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.092104e-04 3.041 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.101372e-04 3.041 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.101372e-04 3.041 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.070464e-03 2.970 0 0
Spry regulation of FGF signaling R-HSA-1295596 9.309964e-04 3.031 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.861120e-04 3.006 0 0
p75NTR signals via NF-kB R-HSA-193639 9.309964e-04 3.031 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 9.309964e-04 3.031 0 0
NF-kB is activated and signals survival R-HSA-209560 1.070464e-03 2.970 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.001383e-03 2.999 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.011928e-03 2.995 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.178618e-04 3.037 0 0
PTEN Regulation R-HSA-6807070 1.089557e-03 2.963 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.101901e-03 2.958 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.101901e-03 2.958 0 0
Ub-specific processing proteases R-HSA-5689880 1.103455e-03 2.957 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.144107e-03 2.942 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.215299e-03 2.915 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.234272e-03 2.909 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.234272e-03 2.909 0 0
Signaling by EGFR R-HSA-177929 1.265858e-03 2.898 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.281696e-03 2.892 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.284311e-03 2.891 0 0
Interleukin-12 family signaling R-HSA-447115 1.297020e-03 2.887 0 0
Centrosome maturation R-HSA-380287 1.298678e-03 2.886 0 0
Nephrin family interactions R-HSA-373753 1.352201e-03 2.869 0 0
Nuclear import of Rev protein R-HSA-180746 1.380886e-03 2.860 0 0
HATs acetylate histones R-HSA-3214847 1.403464e-03 2.853 0 0
Semaphorin interactions R-HSA-373755 1.430659e-03 2.844 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.465986e-03 2.834 0 0
Meiotic recombination R-HSA-912446 1.504903e-03 2.822 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.541747e-03 2.812 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.578565e-03 2.802 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.623523e-03 2.790 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.682698e-03 2.774 0 0
Oncogene Induced Senescence R-HSA-2559585 1.682698e-03 2.774 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.704648e-03 2.768 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.736817e-03 2.760 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.902996e-03 2.721 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.902996e-03 2.721 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.758136e-03 2.755 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.864817e-03 2.729 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.758136e-03 2.755 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.985789e-03 2.702 0 0
Signaling by VEGF R-HSA-194138 1.801170e-03 2.744 0 0
Translation R-HSA-72766 2.088551e-03 2.680 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.021104e-03 2.694 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.107074e-03 2.676 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.154635e-03 2.667 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.159146e-03 2.666 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.260535e-03 2.646 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.260535e-03 2.646 0 0
Kinesins R-HSA-983189 2.301121e-03 2.638 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.306799e-03 2.637 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.330302e-03 2.633 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.342684e-03 2.630 0 0
Death Receptor Signaling R-HSA-73887 2.415980e-03 2.617 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.449530e-03 2.611 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.449530e-03 2.611 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.496316e-03 2.603 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.500468e-03 2.602 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.529596e-03 2.597 0 0
Josephin domain DUBs R-HSA-5689877 2.529596e-03 2.597 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.619441e-03 2.582 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.619441e-03 2.582 0 0
Amyloid fiber formation R-HSA-977225 2.785082e-03 2.555 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.832164e-03 2.548 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.832164e-03 2.548 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.868241e-03 2.542 0 0
Co-inhibition by PD-1 R-HSA-389948 2.889115e-03 2.539 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.938985e-03 2.532 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.952939e-03 2.530 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.975842e-03 2.526 0 0
Ephrin signaling R-HSA-3928664 3.013974e-03 2.521 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.013974e-03 2.521 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.038553e-03 2.517 0 0
HIV Life Cycle R-HSA-162587 3.100041e-03 2.509 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.135771e-03 2.504 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.349587e-03 2.475 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.417626e-03 2.466 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.417626e-03 2.466 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.623158e-03 2.441 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.623158e-03 2.441 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 3.681003e-03 2.434 0 0
Developmental Biology R-HSA-1266738 3.755378e-03 2.425 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.941563e-03 2.404 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.952761e-03 2.403 0 0
Regulation of PTEN localization R-HSA-8948747 4.077693e-03 2.390 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.096248e-03 2.388 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.466388e-03 2.350 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.466388e-03 2.350 0 0
Neurodegenerative Diseases R-HSA-8863678 4.466388e-03 2.350 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.466388e-03 2.350 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.490549e-03 2.348 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 4.924904e-03 2.308 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.775776e-03 2.321 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.508139e-03 2.259 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.833576e-03 2.316 0 0
TGFBR3 expression R-HSA-9839394 5.489563e-03 2.260 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.878073e-03 2.312 0 0
Telomere Maintenance R-HSA-157579 4.969865e-03 2.304 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.033614e-03 2.298 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.439929e-03 2.264 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.439929e-03 2.264 0 0
Generic Transcription Pathway R-HSA-212436 4.888977e-03 2.311 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.742694e-03 2.241 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.033614e-03 2.298 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.689172e-03 2.329 0 0
Host Interactions of HIV factors R-HSA-162909 5.616414e-03 2.251 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.563140e-03 2.255 0 0
Negative regulation of FLT3 R-HSA-9706369 5.190221e-03 2.285 0 0
Glucose metabolism R-HSA-70326 5.756192e-03 2.240 0 0
FLT3 signaling in disease R-HSA-9682385 5.773576e-03 2.239 0 0
Signaling by ERBB4 R-HSA-1236394 5.942666e-03 2.226 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.044160e-03 2.219 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.044160e-03 2.219 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.044160e-03 2.219 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.294751e-03 2.201 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.294751e-03 2.201 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.515167e-03 2.186 0 0
MTOR signalling R-HSA-165159 6.578235e-03 2.182 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.661613e-03 2.176 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.661613e-03 2.176 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.661613e-03 2.176 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.685058e-03 2.175 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.685058e-03 2.175 0 0
Disorders of Developmental Biology R-HSA-9675151 6.697843e-03 2.174 0 0
Signaling by NOTCH3 R-HSA-9012852 6.734369e-03 2.172 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.793622e-03 2.168 0 0
Cleavage of the damaged purine R-HSA-110331 6.793622e-03 2.168 0 0
Disorders of Nervous System Development R-HSA-9697154 6.810086e-03 2.167 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.810086e-03 2.167 0 0
Pervasive developmental disorders R-HSA-9005895 6.810086e-03 2.167 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.810086e-03 2.167 0 0
tRNA processing in the nucleus R-HSA-6784531 7.072797e-03 2.150 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.648923e-03 2.116 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.648923e-03 2.116 0 0
Depurination R-HSA-73927 7.949402e-03 2.100 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.070676e-03 2.093 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.129280e-03 2.090 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.129280e-03 2.090 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.178439e-03 2.087 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.312501e-03 2.080 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.374033e-03 2.077 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.596935e-03 2.066 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.596935e-03 2.066 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.605602e-03 2.065 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.987931e-03 2.046 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.991985e-03 2.046 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 9.001502e-03 2.046 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.528586e-03 2.021 0 0
Striated Muscle Contraction R-HSA-390522 9.577133e-03 2.019 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.664534e-03 2.015 0 0
Maturation of protein E R-HSA-9683683 9.915326e-03 2.004 0 0
Maturation of protein E R-HSA-9694493 9.915326e-03 2.004 0 0
Signaling by WNT R-HSA-195721 9.976779e-03 2.001 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.008621e-02 1.996 0 0
DAG and IP3 signaling R-HSA-1489509 1.008621e-02 1.996 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.065534e-02 1.972 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.071421e-02 1.970 0 0
Reproduction R-HSA-1474165 1.079699e-02 1.967 0 0
Protein folding R-HSA-391251 1.103122e-02 1.957 0 0
EPH-Ephrin signaling R-HSA-2682334 1.103122e-02 1.957 0 0
snRNP Assembly R-HSA-191859 1.105519e-02 1.956 0 0
Metabolism of non-coding RNA R-HSA-194441 1.105519e-02 1.956 0 0
Dual Incision in GG-NER R-HSA-5696400 1.121386e-02 1.950 0 0
RAF activation R-HSA-5673000 1.121386e-02 1.950 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.132291e-02 1.946 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.153123e-02 1.938 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.165561e-02 1.933 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.181212e-02 1.928 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.181212e-02 1.928 0 0
Pexophagy R-HSA-9664873 1.181212e-02 1.928 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.181212e-02 1.928 0 0
FasL/ CD95L signaling R-HSA-75157 1.541918e-02 1.812 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.541918e-02 1.812 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.541918e-02 1.812 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 1.466951e-02 1.834 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.481806e-02 1.829 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.481806e-02 1.829 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.481806e-02 1.829 0 0
EGFR downregulation R-HSA-182971 1.587801e-02 1.799 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.233709e-02 1.909 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.447886e-02 1.839 0 0
Translesion Synthesis by POLH R-HSA-110320 1.317051e-02 1.880 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.587801e-02 1.799 0 0
CaM pathway R-HSA-111997 1.511196e-02 1.821 0 0
Calmodulin induced events R-HSA-111933 1.511196e-02 1.821 0 0
Protein methylation R-HSA-8876725 1.481806e-02 1.829 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.256612e-02 1.901 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.353416e-02 1.869 0 0
HCMV Infection R-HSA-9609646 1.583809e-02 1.800 0 0
Signaling by NOTCH1 R-HSA-1980143 1.541122e-02 1.812 0 0
Platelet degranulation R-HSA-114608 1.414834e-02 1.849 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.481806e-02 1.829 0 0
Smooth Muscle Contraction R-HSA-445355 1.208197e-02 1.918 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.238720e-02 1.907 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.575926e-02 1.802 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.234669e-02 1.908 0 0
Selenoamino acid metabolism R-HSA-2408522 1.566768e-02 1.805 0 0
Ca-dependent events R-HSA-111996 1.617099e-02 1.791 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.617099e-02 1.791 0 0
Depyrimidination R-HSA-73928 1.617099e-02 1.791 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.629277e-02 1.788 0 0
Interferon alpha/beta signaling R-HSA-909733 1.663916e-02 1.779 0 0
Gap junction trafficking and regulation R-HSA-157858 1.683088e-02 1.774 0 0
HIV Infection R-HSA-162906 1.697559e-02 1.770 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.713365e-02 1.766 0 0
TNF signaling R-HSA-75893 1.717906e-02 1.765 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.717906e-02 1.765 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.728614e-02 1.762 0 0
Signaling by PTK6 R-HSA-8848021 1.728614e-02 1.762 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.740216e-02 1.759 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.740216e-02 1.759 0 0
Vesicle-mediated transport R-HSA-5653656 1.792515e-02 1.747 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.841319e-02 1.735 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.841319e-02 1.735 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.841319e-02 1.735 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.841319e-02 1.735 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.841319e-02 1.735 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.841319e-02 1.735 0 0
G0 and Early G1 R-HSA-1538133 1.848656e-02 1.733 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.848656e-02 1.733 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.872151e-02 1.728 0 0
Regulation of CDH1 Function R-HSA-9764561 1.919631e-02 1.717 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.925635e-02 1.715 0 0
Metalloprotease DUBs R-HSA-5689901 1.925635e-02 1.715 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.943011e-02 1.712 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.943011e-02 1.712 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 1.943011e-02 1.712 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.993868e-02 1.700 0 0
Signaling by TGFB family members R-HSA-9006936 2.003069e-02 1.698 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.081939e-02 1.682 0 0
Nucleotide Excision Repair R-HSA-5696398 2.115083e-02 1.675 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.115083e-02 1.675 0 0
Integrin signaling R-HSA-354192 2.139292e-02 1.670 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.139292e-02 1.670 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.146116e-02 1.668 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.209220e-02 1.656 0 0
Signaling by MET R-HSA-6806834 2.247511e-02 1.648 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.258543e-02 1.646 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.283522e-02 1.641 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.323258e-02 1.634 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.353055e-02 1.628 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.383101e-02 1.623 0 0
Regulation of gap junction activity R-HSA-191650 2.472790e-02 1.607 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.472790e-02 1.607 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.472790e-02 1.607 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 2.472790e-02 1.607 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.580513e-02 1.588 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.608576e-02 1.584 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.608576e-02 1.584 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.608576e-02 1.584 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.608576e-02 1.584 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.608576e-02 1.584 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.630037e-02 1.580 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.631865e-02 1.580 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.631865e-02 1.580 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.631865e-02 1.580 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.631865e-02 1.580 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.631865e-02 1.580 0 0
Notch-HLH transcription pathway R-HSA-350054 2.751875e-02 1.560 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.776377e-02 1.557 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.776377e-02 1.557 0 0
RSK activation R-HSA-444257 2.795348e-02 1.554 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.795348e-02 1.554 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.795348e-02 1.554 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.816444e-02 1.550 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.907631e-02 1.536 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.916103e-02 1.535 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.938023e-02 1.532 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.953561e-02 1.530 0 0
Cilium Assembly R-HSA-5617833 3.010652e-02 1.521 0 0
Late endosomal microautophagy R-HSA-9615710 3.042010e-02 1.517 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.042010e-02 1.517 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.042010e-02 1.517 0 0
TCR signaling R-HSA-202403 3.073084e-02 1.512 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.073084e-02 1.512 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.073084e-02 1.512 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.206009e-02 1.494 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.231193e-02 1.491 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.231193e-02 1.491 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.232441e-02 1.490 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.255934e-02 1.487 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.255934e-02 1.487 0 0
MAP2K and MAPK activation R-HSA-5674135 3.281499e-02 1.484 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.334721e-02 1.477 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.334721e-02 1.477 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.396197e-02 1.469 0 0
Activation of BH3-only proteins R-HSA-114452 3.496193e-02 1.456 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.874817e-02 1.412 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.055136e-02 1.296 0 0
Regulation of CDH11 function R-HSA-9762292 4.662700e-02 1.331 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.995205e-02 1.398 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 4.828477e-02 1.316 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.828477e-02 1.316 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.828477e-02 1.316 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.828477e-02 1.316 0 0
Regulation of signaling by CBL R-HSA-912631 3.961039e-02 1.402 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.961039e-02 1.402 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.961039e-02 1.402 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.657270e-02 1.332 0 0
Deadenylation of mRNA R-HSA-429947 3.763264e-02 1.424 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.677825e-02 1.434 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.195275e-02 1.284 0 0
DNA Damage Bypass R-HSA-73893 3.663169e-02 1.436 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.567333e-02 1.340 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.126493e-02 1.290 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.660294e-02 1.436 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.995205e-02 1.398 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.055136e-02 1.296 0 0
Translesion synthesis by REV1 R-HSA-110312 4.828477e-02 1.316 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.660294e-02 1.436 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.631427e-02 1.440 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.663169e-02 1.436 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.995205e-02 1.398 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.677825e-02 1.434 0 0
Gap junction trafficking R-HSA-190828 4.567333e-02 1.340 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.961039e-02 1.402 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.594662e-02 1.338 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.657270e-02 1.332 0 0
Signaling by FGFR4 R-HSA-5654743 4.106121e-02 1.387 0 0
Signaling by FGFR3 R-HSA-5654741 5.062306e-02 1.296 0 0
DNA Replication R-HSA-69306 5.399574e-02 1.268 0 0
Signal regulatory protein family interactions R-HSA-391160 3.995205e-02 1.398 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.995205e-02 1.398 0 0
Basigin interactions R-HSA-210991 5.424793e-02 1.266 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.349832e-02 1.362 0 0
Signaling by NOTCH4 R-HSA-9013694 4.797083e-02 1.319 0 0
Immune System R-HSA-168256 3.763660e-02 1.424 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.860540e-02 1.413 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.938767e-02 1.306 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.591775e-02 1.252 0 0
Signaling by TGFBR3 R-HSA-9839373 5.591775e-02 1.252 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.691812e-02 1.245 0 0
PLC beta mediated events R-HSA-112043 5.699136e-02 1.244 0 0
Generation of second messenger molecules R-HSA-202433 5.714442e-02 1.243 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.752578e-02 1.240 0 0
Translesion synthesis by POLI R-HSA-5656121 5.756781e-02 1.240 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.762976e-02 1.239 0 0
PECAM1 interactions R-HSA-210990 5.802282e-02 1.236 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.802282e-02 1.236 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.938681e-02 1.226 0 0
Muscle contraction R-HSA-397014 6.171251e-02 1.210 0 0
Developmental Cell Lineages R-HSA-9734767 6.182280e-02 1.209 0 0
IRE1alpha activates chaperones R-HSA-381070 6.236873e-02 1.205 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.264423e-02 1.203 0 0
FLT3 Signaling R-HSA-9607240 6.334977e-02 1.198 0 0
Regulation of TP53 Expression R-HSA-6804754 6.446602e-02 1.191 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 6.446602e-02 1.191 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.446602e-02 1.191 0 0
Signaling by NOTCH2 R-HSA-1980145 6.447331e-02 1.191 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.447331e-02 1.191 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.447331e-02 1.191 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.447331e-02 1.191 0 0
Mitophagy R-HSA-5205647 6.447331e-02 1.191 0 0
Gap junction assembly R-HSA-190861 6.447331e-02 1.191 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.447331e-02 1.191 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.449047e-02 1.191 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.485251e-02 1.188 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.688726e-02 1.175 0 0
Signaling by Interleukins R-HSA-449147 6.689755e-02 1.175 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.780124e-02 1.169 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.780124e-02 1.169 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.780124e-02 1.169 0 0
Translesion synthesis by POLK R-HSA-5655862 6.780124e-02 1.169 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.780124e-02 1.169 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.780124e-02 1.169 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.780124e-02 1.169 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.897446e-02 1.161 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.996657e-02 1.155 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.063472e-02 1.151 0 0
NRAGE signals death through JNK R-HSA-193648 7.063472e-02 1.151 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 7.063472e-02 1.151 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.076627e-02 1.150 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.080289e-02 1.150 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.086342e-02 1.150 0 0
Hedgehog 'off' state R-HSA-5610787 7.131786e-02 1.147 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.176413e-02 1.144 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.176413e-02 1.144 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.180023e-02 1.144 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.264418e-02 1.139 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.431442e-02 1.129 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.442673e-02 1.128 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.503853e-02 1.125 0 0
Signaling by FGFR2 R-HSA-5654738 7.526695e-02 1.123 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.556629e-02 1.122 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.897541e-02 1.103 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.897541e-02 1.103 0 0
Glycogen storage diseases R-HSA-3229121 7.897541e-02 1.103 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.897541e-02 1.103 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.137967e-02 1.089 0 0
Dual incision in TC-NER R-HSA-6782135 8.316026e-02 1.080 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.481449e-02 1.072 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.481449e-02 1.072 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.481449e-02 1.072 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.481449e-02 1.072 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.481449e-02 1.072 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 8.530315e-02 1.069 0 0
TRIF-mediated programmed cell death R-HSA-2562578 8.530315e-02 1.069 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 8.530315e-02 1.069 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 8.530315e-02 1.069 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.530315e-02 1.069 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.824528e-02 1.054 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.064422e-02 1.043 0 0
Trafficking of AMPA receptors R-HSA-399719 9.069396e-02 1.042 0 0
Polo-like kinase mediated events R-HSA-156711 9.107157e-02 1.041 0 0
G-protein mediated events R-HSA-112040 9.122602e-02 1.040 0 0
Base Excision Repair R-HSA-73884 9.188222e-02 1.037 0 0
G1 Phase R-HSA-69236 9.231006e-02 1.035 0 0
Cyclin D associated events in G1 R-HSA-69231 9.231006e-02 1.035 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.352913e-02 1.029 0 0
MET interacts with TNS proteins R-HSA-8875513 9.432331e-02 1.025 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 9.432331e-02 1.025 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 9.432331e-02 1.025 0 0
Neurexins and neuroligins R-HSA-6794361 9.519446e-02 1.021 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.519446e-02 1.021 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.634707e-02 1.016 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 9.761766e-02 1.010 0 0
PDGFR mutants bind TKIs R-HSA-9674428 9.761766e-02 1.010 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.761766e-02 1.010 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 9.761766e-02 1.010 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 9.761766e-02 1.010 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 9.761766e-02 1.010 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 9.761766e-02 1.010 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 9.761766e-02 1.010 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 9.761766e-02 1.010 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 9.761766e-02 1.010 0 0
Regulated Necrosis R-HSA-5218859 9.794185e-02 1.009 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.001086e-01 1.000 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.005886e-01 0.997 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.005886e-01 0.997 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.005886e-01 0.997 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.005886e-01 0.997 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.026841e-01 0.988 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.026841e-01 0.988 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.026841e-01 0.988 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.030100e-01 0.987 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 1.034093e-01 0.985 0 0
Rap1 signalling R-HSA-392517 1.040626e-01 0.983 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.049477e-01 0.979 0 0
Regulation by c-FLIP R-HSA-3371378 1.056066e-01 0.976 0 0
Dimerization of procaspase-8 R-HSA-69416 1.056066e-01 0.976 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.056066e-01 0.976 0 0
Formation of annular gap junctions R-HSA-196025 1.056066e-01 0.976 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.056066e-01 0.976 0 0
RAS processing R-HSA-9648002 1.059518e-01 0.975 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.110303e-01 0.955 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.110303e-01 0.955 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.110303e-01 0.955 0 0
Glycogen metabolism R-HSA-8982491 1.156829e-01 0.937 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.165763e-01 0.933 0 0
Regulation of KIT signaling R-HSA-1433559 1.165763e-01 0.933 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.165763e-01 0.933 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 1.179140e-01 0.928 0 0
Glycogen synthesis R-HSA-3322077 1.179140e-01 0.928 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.183734e-01 0.927 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.191028e-01 0.924 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.198239e-01 0.921 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.201128e-01 0.920 0 0
MHC class II antigen presentation R-HSA-2132295 1.204281e-01 0.919 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 1.208101e-01 0.918 0 0
Defective ACTH causes obesity and POMCD R-HSA-5579031 1.857113e-01 0.731 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.857113e-01 0.731 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.857113e-01 0.731 0 0
Hereditary fructose intolerance R-HSA-5657560 1.857113e-01 0.731 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.857113e-01 0.731 0 0
NADE modulates death signalling R-HSA-205025 1.272678e-01 0.895 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.272678e-01 0.895 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.272678e-01 0.895 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.624131e-01 0.789 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.624131e-01 0.789 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.624131e-01 0.789 0 0
IRS activation R-HSA-74713 1.624131e-01 0.789 0 0
ARMS-mediated activation R-HSA-170984 1.275871e-01 0.894 0 0
Gap junction degradation R-HSA-190873 1.275871e-01 0.894 0 0
CASP8 activity is inhibited R-HSA-5218900 1.275871e-01 0.894 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.990161e-01 0.701 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.990161e-01 0.701 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.510246e-01 0.821 0 0
2-LTR circle formation R-HSA-164843 1.510246e-01 0.821 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.510246e-01 0.821 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.364580e-01 0.626 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.364580e-01 0.626 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.341346e-01 0.872 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 1.526920e-01 0.816 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.526920e-01 0.816 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.526920e-01 0.816 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.013841e-01 0.696 0 0
Activation of RAC1 R-HSA-428540 2.013841e-01 0.696 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.013841e-01 0.696 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.325844e-01 0.878 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.278746e-01 0.642 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.278746e-01 0.642 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.480268e-01 0.830 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.279332e-01 0.893 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.924099e-01 0.716 0 0
GAB1 signalosome R-HSA-180292 2.133651e-01 0.671 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.133651e-01 0.671 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.549811e-01 0.810 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.984495e-01 0.702 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.349120e-01 0.629 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.365210e-01 0.865 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.696502e-01 0.770 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.959912e-01 0.708 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.809881e-01 0.742 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.809881e-01 0.742 0 0
UCH proteinases R-HSA-5689603 1.619068e-01 0.791 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.046351e-01 0.689 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.169113e-01 0.664 0 0
Neutrophil degranulation R-HSA-6798695 1.422816e-01 0.847 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.155938e-01 0.666 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.258764e-01 0.900 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.348857e-01 0.629 0 0
DNA strand elongation R-HSA-69190 1.997201e-01 0.700 0 0
FOXO-mediated transcription R-HSA-9614085 1.678154e-01 0.775 0 0
Integration of provirus R-HSA-162592 2.013841e-01 0.696 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.693745e-01 0.771 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.951548e-01 0.710 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.951548e-01 0.710 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.318794e-01 0.635 0 0
DCC mediated attractive signaling R-HSA-418885 1.341346e-01 0.872 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.155938e-01 0.666 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.277066e-01 0.643 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.275871e-01 0.894 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.164267e-01 0.665 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.164267e-01 0.665 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.349120e-01 0.629 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.275871e-01 0.894 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.278746e-01 0.642 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.624965e-01 0.789 0 0
Ion homeostasis R-HSA-5578775 2.169113e-01 0.664 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.999650e-01 0.699 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.378301e-01 0.861 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.990161e-01 0.701 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 1.924099e-01 0.716 0 0
Syndecan interactions R-HSA-3000170 1.810167e-01 0.742 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.128182e-01 0.672 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.128182e-01 0.672 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.146799e-01 0.668 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.146799e-01 0.668 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.406674e-01 0.619 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.485280e-01 0.828 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.133651e-01 0.671 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.624131e-01 0.789 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.406674e-01 0.619 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.445280e-01 0.840 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.990161e-01 0.701 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.348857e-01 0.629 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.485341e-01 0.605 0 0
Opioid Signalling R-HSA-111885 1.415154e-01 0.849 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.348857e-01 0.629 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.480268e-01 0.830 0 0
S Phase R-HSA-69242 1.402168e-01 0.853 0 0
Toll-like Receptor Cascades R-HSA-168898 1.942479e-01 0.712 0 0
Adaptive Immune System R-HSA-1280218 2.156350e-01 0.666 0 0
Platelet sensitization by LDL R-HSA-432142 2.133651e-01 0.671 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.318794e-01 0.635 0 0
Netrin-1 signaling R-HSA-373752 1.710218e-01 0.767 0 0
Co-stimulation by CD28 R-HSA-389356 2.223501e-01 0.653 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.549811e-01 0.810 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.857113e-01 0.731 0 0
Inhibition of PKR R-HSA-169131 1.857113e-01 0.731 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.272678e-01 0.895 0 0
Unwinding of DNA R-HSA-176974 1.275871e-01 0.894 0 0
TRAIL signaling R-HSA-75158 1.990161e-01 0.701 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.411563e-01 0.850 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.133651e-01 0.671 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.984495e-01 0.702 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.325844e-01 0.878 0 0
Signaling by FGFR1 R-HSA-5654736 1.286014e-01 0.891 0 0
HCMV Late Events R-HSA-9610379 1.422846e-01 0.847 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.253690e-01 0.902 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.984495e-01 0.702 0 0
Interferon gamma signaling R-HSA-877300 1.539741e-01 0.813 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.523126e-01 0.817 0 0
Signaling by FGFR R-HSA-190236 2.365651e-01 0.626 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.314832e-01 0.881 0 0
Nef and signal transduction R-HSA-164944 2.364580e-01 0.626 0 0
LGI-ADAM interactions R-HSA-5682910 1.756967e-01 0.755 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 1.473968e-01 0.832 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.529492e-01 0.815 0 0
G1/S Transition R-HSA-69206 2.000748e-01 0.699 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.359950e-01 0.627 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.485341e-01 0.605 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.274615e-01 0.643 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.591096e-01 0.798 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.641896e-01 0.785 0 0
MAP kinase activation R-HSA-450294 1.780337e-01 0.749 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.325844e-01 0.878 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.711228e-01 0.767 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.476038e-01 0.831 0 0
Infectious disease R-HSA-5663205 1.968716e-01 0.706 0 0
Gluconeogenesis R-HSA-70263 1.278678e-01 0.893 0 0
CASP4 inflammasome assembly R-HSA-9948001 1.510246e-01 0.821 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.364580e-01 0.626 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.648689e-01 0.783 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.258764e-01 0.900 0 0
CREB phosphorylation R-HSA-199920 2.364580e-01 0.626 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.155938e-01 0.666 0 0
Sensory processing of sound R-HSA-9659379 1.903010e-01 0.721 0 0
Signaling by ALK R-HSA-201556 1.985377e-01 0.702 0 0
Diseases of DNA repair R-HSA-9675135 1.959912e-01 0.708 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 1.624131e-01 0.789 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.721509e-01 0.764 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.480268e-01 0.830 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.485341e-01 0.605 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.843003e-01 0.734 0 0
Inositol phosphate metabolism R-HSA-1483249 1.452986e-01 0.838 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.985377e-01 0.702 0 0
Regulation of BACH1 activity R-HSA-9708530 1.526920e-01 0.816 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.286014e-01 0.891 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.325844e-01 0.878 0 0
Translation of Structural Proteins R-HSA-9683701 2.424368e-01 0.615 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.624131e-01 0.789 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.499187e-01 0.602 0 0
Signaling by Hedgehog R-HSA-5358351 2.502677e-01 0.602 0 0
Hemostasis R-HSA-109582 2.527675e-01 0.597 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.537629e-01 0.596 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.537629e-01 0.596 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.537629e-01 0.596 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.549663e-01 0.594 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 2.549663e-01 0.594 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.553373e-01 0.593 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.569473e-01 0.590 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.569473e-01 0.590 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.569473e-01 0.590 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.569473e-01 0.590 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.569473e-01 0.590 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.569473e-01 0.590 0 0
Signal transduction by L1 R-HSA-445144 2.569473e-01 0.590 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.649619e-01 0.577 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.652096e-01 0.576 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 2.652096e-01 0.576 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.652096e-01 0.576 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 2.652096e-01 0.576 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.652096e-01 0.576 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 2.652096e-01 0.576 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.652096e-01 0.576 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.652096e-01 0.576 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.652096e-01 0.576 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.652096e-01 0.576 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 2.652096e-01 0.576 0 0
Beta-ketothiolase deficiency R-HSA-9915355 2.652096e-01 0.576 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.652096e-01 0.576 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.652096e-01 0.576 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.652096e-01 0.576 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.652096e-01 0.576 0 0
Circadian clock R-HSA-9909396 2.677265e-01 0.572 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.695671e-01 0.569 0 0
HIV elongation arrest and recovery R-HSA-167287 2.729947e-01 0.564 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.729947e-01 0.564 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.729947e-01 0.564 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.732565e-01 0.563 0 0
G alpha (12/13) signalling events R-HSA-416482 2.740837e-01 0.562 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.742264e-01 0.562 0 0
SOS-mediated signalling R-HSA-112412 2.742264e-01 0.562 0 0
Recycling of eIF2:GDP R-HSA-72731 2.742264e-01 0.562 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.742264e-01 0.562 0 0
CHL1 interactions R-HSA-447041 2.742264e-01 0.562 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.742264e-01 0.562 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.742264e-01 0.562 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.785044e-01 0.555 0 0
Orc1 removal from chromatin R-HSA-68949 2.785044e-01 0.555 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.793693e-01 0.554 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.793693e-01 0.554 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.793693e-01 0.554 0 0
CRMPs in Sema3A signaling R-HSA-399956 2.824693e-01 0.549 0 0
Non-canonical inflammasome activation R-HSA-9686114 2.824693e-01 0.549 0 0
RET signaling R-HSA-8853659 2.827761e-01 0.549 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.827761e-01 0.549 0 0
RNA Polymerase III Transcription R-HSA-74158 2.827761e-01 0.549 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.827761e-01 0.549 0 0
GPVI-mediated activation cascade R-HSA-114604 2.827761e-01 0.549 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.845266e-01 0.546 0 0
Interleukin-17 signaling R-HSA-448424 2.845266e-01 0.546 0 0
Platelet calcium homeostasis R-HSA-418360 2.925180e-01 0.534 0 0
DARPP-32 events R-HSA-180024 2.925180e-01 0.534 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.931162e-01 0.533 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.931162e-01 0.533 0 0
Hedgehog 'on' state R-HSA-5632684 2.973919e-01 0.527 0 0
Degradation of DVL R-HSA-4641258 3.002755e-01 0.522 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.020797e-01 0.520 0 0
Assembly Of The HIV Virion R-HSA-175474 3.020797e-01 0.520 0 0
RSV-host interactions R-HSA-9833110 3.090902e-01 0.510 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.102076e-01 0.508 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.102076e-01 0.508 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.102076e-01 0.508 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.102076e-01 0.508 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.104037e-01 0.508 0 0
ER-Phagosome pathway R-HSA-1236974 3.104218e-01 0.508 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.119012e-01 0.506 0 0
Type I hemidesmosome assembly R-HSA-446107 3.119012e-01 0.506 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.119012e-01 0.506 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.119012e-01 0.506 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.119012e-01 0.506 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.119012e-01 0.506 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.122704e-01 0.505 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.137582e-01 0.503 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.151710e-01 0.501 0 0
MET promotes cell motility R-HSA-8875878 3.179688e-01 0.498 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.211715e-01 0.493 0 0
Ca2+ pathway R-HSA-4086398 3.235450e-01 0.490 0 0
FGFR2 alternative splicing R-HSA-6803529 3.249838e-01 0.488 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.249838e-01 0.488 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.249838e-01 0.488 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.321913e-01 0.479 0 0
Downstream signal transduction R-HSA-186763 3.321913e-01 0.479 0 0
Budding and maturation of HIV virion R-HSA-162588 3.321913e-01 0.479 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.358130e-01 0.474 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.358130e-01 0.474 0 0
Stabilization of p53 R-HSA-69541 3.358130e-01 0.474 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.358130e-01 0.474 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.358130e-01 0.474 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 3.369508e-01 0.472 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.369508e-01 0.472 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.369508e-01 0.472 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.369508e-01 0.472 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 3.369508e-01 0.472 0 0
C6 deamination of adenosine R-HSA-75102 3.369508e-01 0.472 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.369508e-01 0.472 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.369508e-01 0.472 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.369508e-01 0.472 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.374620e-01 0.472 0 0
Cellular response to hypoxia R-HSA-1234174 3.376158e-01 0.472 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.380199e-01 0.471 0 0
Prolonged ERK activation events R-HSA-169893 3.380199e-01 0.471 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.479917e-01 0.458 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.479917e-01 0.458 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.479917e-01 0.458 0 0
Growth hormone receptor signaling R-HSA-982772 3.479917e-01 0.458 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.491408e-01 0.457 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.491408e-01 0.457 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.491408e-01 0.457 0 0
Lipophagy R-HSA-9613354 3.491408e-01 0.457 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.491408e-01 0.457 0 0
WNT mediated activation of DVL R-HSA-201688 3.491408e-01 0.457 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.491408e-01 0.457 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 3.491408e-01 0.457 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 3.491408e-01 0.457 0 0
ALK mutants bind TKIs R-HSA-9700645 3.491408e-01 0.457 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.491408e-01 0.457 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.491408e-01 0.457 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.491408e-01 0.457 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.522217e-01 0.453 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.529860e-01 0.452 0 0
HIV Transcription Elongation R-HSA-167169 3.537658e-01 0.451 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.537658e-01 0.451 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.537658e-01 0.451 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.537658e-01 0.451 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.537658e-01 0.451 0 0
Intraflagellar transport R-HSA-5620924 3.538583e-01 0.451 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.609883e-01 0.443 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.657597e-01 0.437 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.673024e-01 0.435 0 0
Interleukin-1 signaling R-HSA-9020702 3.673024e-01 0.435 0 0
Potential therapeutics for SARS R-HSA-9679191 3.681123e-01 0.434 0 0
Degradation of CDH1 R-HSA-9766229 3.703287e-01 0.431 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.717861e-01 0.430 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.717861e-01 0.430 0 0
Nuclear RNA decay R-HSA-9930044 3.723048e-01 0.429 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.856713e-01 0.414 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.856713e-01 0.414 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.856713e-01 0.414 0 0
PI3K/AKT activation R-HSA-198203 3.856713e-01 0.414 0 0
Signal attenuation R-HSA-74749 3.856713e-01 0.414 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.856713e-01 0.414 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.856713e-01 0.414 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.856713e-01 0.414 0 0
Signaling by Leptin R-HSA-2586552 3.856713e-01 0.414 0 0
Disease R-HSA-1643685 3.871427e-01 0.412 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.898339e-01 0.409 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.898339e-01 0.409 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.898339e-01 0.409 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.898339e-01 0.409 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.923864e-01 0.406 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.932953e-01 0.405 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.939845e-01 0.405 0 0
Interleukin-7 signaling R-HSA-1266695 3.939845e-01 0.405 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.016914e-01 0.396 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.016914e-01 0.396 0 0
PLC-gamma1 signalling R-HSA-167021 4.016914e-01 0.396 0 0
Axonal growth stimulation R-HSA-209563 4.016914e-01 0.396 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.016914e-01 0.396 0 0
MET activates PTPN11 R-HSA-8865999 4.016914e-01 0.396 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.016914e-01 0.396 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.016914e-01 0.396 0 0
Histamine receptors R-HSA-390650 4.016914e-01 0.396 0 0
The NLRP1 inflammasome R-HSA-844455 4.016914e-01 0.396 0 0
Transmission across Chemical Synapses R-HSA-112315 4.043963e-01 0.393 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.124148e-01 0.385 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 4.124148e-01 0.385 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.124148e-01 0.385 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.168162e-01 0.380 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.168162e-01 0.380 0 0
Myogenesis R-HSA-525793 4.168162e-01 0.380 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.168162e-01 0.380 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.198806e-01 0.377 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.198806e-01 0.377 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.205101e-01 0.376 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.205101e-01 0.376 0 0
Signaling by APC mutants R-HSA-4839744 4.212763e-01 0.375 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.212763e-01 0.375 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.212763e-01 0.375 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.212763e-01 0.375 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.212763e-01 0.375 0 0
Bicarbonate transporters R-HSA-425381 4.212763e-01 0.375 0 0
vRNP Assembly R-HSA-192905 4.212763e-01 0.375 0 0
Interleukin-2 signaling R-HSA-9020558 4.212763e-01 0.375 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.212763e-01 0.375 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.258599e-01 0.371 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.296288e-01 0.367 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.323415e-01 0.364 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.323415e-01 0.364 0 0
Regulation of Apoptosis R-HSA-169911 4.323415e-01 0.364 0 0
PERK regulates gene expression R-HSA-381042 4.323415e-01 0.364 0 0
Amino acids regulate mTORC1 R-HSA-9639288 4.363479e-01 0.360 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.394455e-01 0.357 0 0
Cristae formation R-HSA-8949613 4.394455e-01 0.357 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.394455e-01 0.357 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.394455e-01 0.357 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.394455e-01 0.357 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.394455e-01 0.357 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.473013e-01 0.349 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.473013e-01 0.349 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.473013e-01 0.349 0 0
The NLRP3 inflammasome R-HSA-844456 4.473013e-01 0.349 0 0
Other interleukin signaling R-HSA-449836 4.473013e-01 0.349 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.521133e-01 0.345 0 0
RUNX2 regulates bone development R-HSA-8941326 4.521209e-01 0.345 0 0
G1/S-Specific Transcription R-HSA-69205 4.521209e-01 0.345 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.557884e-01 0.341 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.557884e-01 0.341 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.557884e-01 0.341 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.557884e-01 0.341 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.557884e-01 0.341 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.557884e-01 0.341 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.557884e-01 0.341 0 0
Signaling by AXIN mutants R-HSA-4839735 4.557884e-01 0.341 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.601141e-01 0.337 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.601141e-01 0.337 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.601141e-01 0.337 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.601141e-01 0.337 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.601141e-01 0.337 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.601141e-01 0.337 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.601141e-01 0.337 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.601141e-01 0.337 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.601141e-01 0.337 0 0
GABA synthesis R-HSA-888568 4.601141e-01 0.337 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.601141e-01 0.337 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.601141e-01 0.337 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.601141e-01 0.337 0 0
Stimuli-sensing channels R-HSA-2672351 4.613634e-01 0.336 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.615560e-01 0.336 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.615560e-01 0.336 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.615560e-01 0.336 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.618104e-01 0.336 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.618104e-01 0.336 0 0
Inflammasomes R-HSA-622312 4.618104e-01 0.336 0 0
ABC-family proteins mediated transport R-HSA-382556 4.686810e-01 0.329 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 4.717104e-01 0.326 0 0
Degradation of AXIN R-HSA-4641257 4.717104e-01 0.326 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.717104e-01 0.326 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.735799e-01 0.325 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.735799e-01 0.325 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.791983e-01 0.319 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 4.805498e-01 0.318 0 0
Iron uptake and transport R-HSA-917937 4.805498e-01 0.318 0 0
Signaling by Erythropoietin R-HSA-9006335 4.838550e-01 0.315 0 0
mRNA Capping R-HSA-72086 4.838550e-01 0.315 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.838550e-01 0.315 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.890817e-01 0.311 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.890817e-01 0.311 0 0
Polymerase switching R-HSA-69091 4.890817e-01 0.311 0 0
Leading Strand Synthesis R-HSA-69109 4.890817e-01 0.311 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.890817e-01 0.311 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.890817e-01 0.311 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.890817e-01 0.311 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.890817e-01 0.311 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.890817e-01 0.311 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.890817e-01 0.311 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.890817e-01 0.311 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.890817e-01 0.311 0 0
Regulation of IFNG signaling R-HSA-877312 4.890817e-01 0.311 0 0
Protein localization R-HSA-9609507 4.904080e-01 0.309 0 0
Cellular response to chemical stress R-HSA-9711123 4.940917e-01 0.306 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.966636e-01 0.304 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.966636e-01 0.304 0 0
Lagging Strand Synthesis R-HSA-69186 4.992698e-01 0.302 0 0
ERK/MAPK targets R-HSA-198753 4.992698e-01 0.302 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.995198e-01 0.301 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.019488e-01 0.299 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.024120e-01 0.299 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.055288e-01 0.296 0 0
DAP12 signaling R-HSA-2424491 5.055288e-01 0.296 0 0
Activation of the pre-replicative complex R-HSA-68962 5.055288e-01 0.296 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.055288e-01 0.296 0 0
Interleukin-37 signaling R-HSA-9008059 5.055288e-01 0.296 0 0
Translation of Structural Proteins R-HSA-9694635 5.086310e-01 0.294 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.101661e-01 0.292 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.128352e-01 0.290 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.128352e-01 0.290 0 0
Reelin signalling pathway R-HSA-8866376 5.128352e-01 0.290 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.128352e-01 0.290 0 0
Activation of AKT2 R-HSA-165158 5.128352e-01 0.290 0 0
PTK6 Down-Regulation R-HSA-8849472 5.128352e-01 0.290 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.128352e-01 0.290 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.128352e-01 0.290 0 0
Co-inhibition by BTLA R-HSA-9927353 5.128352e-01 0.290 0 0
NrCAM interactions R-HSA-447038 5.128352e-01 0.290 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.128352e-01 0.290 0 0
Transcription of the HIV genome R-HSA-167172 5.199550e-01 0.284 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.210651e-01 0.283 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.210651e-01 0.283 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.210651e-01 0.283 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.210651e-01 0.283 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.210651e-01 0.283 0 0
Frs2-mediated activation R-HSA-170968 5.210651e-01 0.283 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.210651e-01 0.283 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.210651e-01 0.283 0 0
Maturation of nucleoprotein R-HSA-9683610 5.210651e-01 0.283 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.210651e-01 0.283 0 0
PCP/CE pathway R-HSA-4086400 5.224999e-01 0.282 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.238161e-01 0.281 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.243067e-01 0.280 0 0
Attachment and Entry R-HSA-9694614 5.243067e-01 0.280 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.243067e-01 0.280 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.243067e-01 0.280 0 0
Pyruvate metabolism R-HSA-70268 5.248294e-01 0.280 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.289633e-01 0.277 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.309553e-01 0.275 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.309553e-01 0.275 0 0
Peroxisomal protein import R-HSA-9033241 5.328143e-01 0.273 0 0
Signaling by NTRKs R-HSA-166520 5.376384e-01 0.270 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.474328e-01 0.262 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 5.486376e-01 0.261 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.490101e-01 0.260 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.498236e-01 0.260 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.516771e-01 0.258 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.516771e-01 0.258 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.516771e-01 0.258 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.516771e-01 0.258 0 0
Physiological factors R-HSA-5578768 5.516771e-01 0.258 0 0
Malate-aspartate shuttle R-HSA-9856872 5.516771e-01 0.258 0 0
Zinc transporters R-HSA-435354 5.516771e-01 0.258 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.563731e-01 0.255 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.604107e-01 0.251 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.604107e-01 0.251 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.604107e-01 0.251 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.604107e-01 0.251 0 0
Ceramide signalling R-HSA-193681 5.604107e-01 0.251 0 0
Cam-PDE 1 activation R-HSA-111957 5.604107e-01 0.251 0 0
Phosphorylation of Emi1 R-HSA-176417 5.604107e-01 0.251 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.604107e-01 0.251 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.604107e-01 0.251 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.604107e-01 0.251 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.604107e-01 0.251 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.604107e-01 0.251 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.604107e-01 0.251 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.604107e-01 0.251 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.604107e-01 0.251 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.604107e-01 0.251 0 0
Downstream TCR signaling R-HSA-202424 5.634291e-01 0.249 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.637426e-01 0.249 0 0
Synthesis of DNA R-HSA-69239 5.641572e-01 0.249 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.642363e-01 0.249 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.642363e-01 0.249 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.655480e-01 0.248 0 0
HIV Transcription Initiation R-HSA-167161 5.655480e-01 0.248 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.655480e-01 0.248 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 5.655480e-01 0.248 0 0
G-protein beta:gamma signalling R-HSA-397795 5.679074e-01 0.246 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.679074e-01 0.246 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.722199e-01 0.242 0 0
Interleukin-1 family signaling R-HSA-446652 5.767237e-01 0.239 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.773220e-01 0.239 0 0
Heme signaling R-HSA-9707616 5.785686e-01 0.238 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.808803e-01 0.236 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.808803e-01 0.236 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.808803e-01 0.236 0 0
Metabolism of proteins R-HSA-392499 5.811774e-01 0.236 0 0
Rab regulation of trafficking R-HSA-9007101 5.866158e-01 0.232 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.877063e-01 0.231 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.933336e-01 0.227 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.950200e-01 0.225 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.006245e-01 0.221 0 0
Signaling by SCF-KIT R-HSA-1433557 6.006245e-01 0.221 0 0
TBC/RABGAPs R-HSA-8854214 6.006245e-01 0.221 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 6.006869e-01 0.221 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.033426e-01 0.219 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.033426e-01 0.219 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.033426e-01 0.219 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.033426e-01 0.219 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.033426e-01 0.219 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.033426e-01 0.219 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.033426e-01 0.219 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.033426e-01 0.219 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.033426e-01 0.219 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.033426e-01 0.219 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.033426e-01 0.219 0 0
HDL clearance R-HSA-8964011 6.033426e-01 0.219 0 0
Signaling by FGFR in disease R-HSA-1226099 6.047854e-01 0.218 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.069642e-01 0.217 0 0
Ion transport by P-type ATPases R-HSA-936837 6.078321e-01 0.216 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.086582e-01 0.216 0 0
Phosphorylation of the APC/C R-HSA-176412 6.086582e-01 0.216 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.086582e-01 0.216 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.086582e-01 0.216 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.086582e-01 0.216 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.086582e-01 0.216 0 0
Attachment and Entry R-HSA-9678110 6.086582e-01 0.216 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.086582e-01 0.216 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.086582e-01 0.216 0 0
Virus Assembly and Release R-HSA-168268 6.086582e-01 0.216 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.119154e-01 0.213 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.170132e-01 0.210 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.170132e-01 0.210 0 0
HDMs demethylate histones R-HSA-3214842 6.170132e-01 0.210 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 6.170132e-01 0.210 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.175476e-01 0.209 0 0
SLC transporter disorders R-HSA-5619102 6.228154e-01 0.206 0 0
Signalling to ERKs R-HSA-187687 6.256613e-01 0.204 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.276214e-01 0.202 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.340395e-01 0.198 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.340395e-01 0.198 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.350104e-01 0.197 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.350104e-01 0.197 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.350104e-01 0.197 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.350104e-01 0.197 0 0
Passive transport by Aquaporins R-HSA-432047 6.350104e-01 0.197 0 0
Synthesis of PG R-HSA-1483148 6.350104e-01 0.197 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.350104e-01 0.197 0 0
MET activates PTK2 signaling R-HSA-8874081 6.381823e-01 0.195 0 0
TRP channels R-HSA-3295583 6.381823e-01 0.195 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.381823e-01 0.195 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.381823e-01 0.195 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.420840e-01 0.192 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.420840e-01 0.192 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.420840e-01 0.192 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.420840e-01 0.192 0 0
Disinhibition of SNARE formation R-HSA-114516 6.420840e-01 0.192 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.420840e-01 0.192 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.420840e-01 0.192 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.420840e-01 0.192 0 0
VLDL clearance R-HSA-8964046 6.420840e-01 0.192 0 0
Netrin mediated repulsion signals R-HSA-418886 6.420840e-01 0.192 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.420840e-01 0.192 0 0
Ion channel transport R-HSA-983712 6.465160e-01 0.189 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.494331e-01 0.187 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.585170e-01 0.181 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.585170e-01 0.181 0 0
Insulin processing R-HSA-264876 6.585170e-01 0.181 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.599505e-01 0.180 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.599505e-01 0.180 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.599505e-01 0.180 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.599505e-01 0.180 0 0
Specification of primordial germ cells R-HSA-9827857 6.599505e-01 0.180 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.691893e-01 0.174 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 6.706918e-01 0.173 0 0
phospho-PLA2 pathway R-HSA-111995 6.770435e-01 0.169 0 0
MET receptor recycling R-HSA-8875656 6.770435e-01 0.169 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.770435e-01 0.169 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.770435e-01 0.169 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.770435e-01 0.169 0 0
Adrenoceptors R-HSA-390696 6.770435e-01 0.169 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.770435e-01 0.169 0 0
Sodium/Proton exchangers R-HSA-425986 6.770435e-01 0.169 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.770435e-01 0.169 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.780131e-01 0.169 0 0
NGF-stimulated transcription R-HSA-9031628 6.808165e-01 0.167 0 0
PKA activation R-HSA-163615 6.835029e-01 0.165 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.835029e-01 0.165 0 0
Mismatch Repair R-HSA-5358508 6.835029e-01 0.165 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.835029e-01 0.165 0 0
Nephron development R-HSA-9831926 6.835029e-01 0.165 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.835029e-01 0.165 0 0
Extension of Telomeres R-HSA-180786 6.844625e-01 0.165 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.886445e-01 0.162 0 0
Pentose phosphate pathway R-HSA-71336 6.945921e-01 0.158 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.057007e-01 0.151 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.057007e-01 0.151 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.057007e-01 0.151 0 0
Maturation of nucleoprotein R-HSA-9694631 7.057007e-01 0.151 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.059784e-01 0.151 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.085902e-01 0.150 0 0
Calcineurin activates NFAT R-HSA-2025928 7.085902e-01 0.150 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.085902e-01 0.150 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.085902e-01 0.150 0 0
mRNA Editing R-HSA-75072 7.085902e-01 0.150 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.085902e-01 0.150 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.085902e-01 0.150 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.085902e-01 0.150 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.085902e-01 0.150 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.085902e-01 0.150 0 0
PI3K Cascade R-HSA-109704 7.096802e-01 0.149 0 0
Azathioprine ADME R-HSA-9748787 7.096802e-01 0.149 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.103282e-01 0.149 0 0
Diseases of Immune System R-HSA-5260271 7.103282e-01 0.149 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.108540e-01 0.148 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.108540e-01 0.148 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.144986e-01 0.146 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.144986e-01 0.146 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.234051e-01 0.141 0 0
Mitochondrial protein import R-HSA-1268020 7.234686e-01 0.141 0 0
Signaling by PDGF R-HSA-186797 7.234686e-01 0.141 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.234686e-01 0.141 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.254635e-01 0.139 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.265837e-01 0.139 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.265837e-01 0.139 0 0
Protein hydroxylation R-HSA-9629569 7.265837e-01 0.139 0 0
Formation of definitive endoderm R-HSA-9823730 7.265837e-01 0.139 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.293539e-01 0.137 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.315039e-01 0.136 0 0
Binding and entry of HIV virion R-HSA-173107 7.370571e-01 0.132 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.370571e-01 0.132 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.370571e-01 0.132 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.370571e-01 0.132 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.370571e-01 0.132 0 0
Interleukin-27 signaling R-HSA-9020956 7.370571e-01 0.132 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.370571e-01 0.132 0 0
Maturation of spike protein R-HSA-9683686 7.370571e-01 0.132 0 0
Post-translational protein modification R-HSA-597592 7.395897e-01 0.131 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.400015e-01 0.131 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.400015e-01 0.131 0 0
tRNA processing R-HSA-72306 7.402569e-01 0.131 0 0
Adipogenesis R-HSA-9843745 7.416590e-01 0.130 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.461970e-01 0.127 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.461970e-01 0.127 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.461970e-01 0.127 0 0
IGF1R signaling cascade R-HSA-2428924 7.475297e-01 0.126 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.478668e-01 0.126 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.531568e-01 0.123 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.539479e-01 0.123 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.539479e-01 0.123 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.558828e-01 0.122 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.589774e-01 0.120 0 0
Conjugation of benzoate with glycine R-HSA-177135 7.627447e-01 0.118 0 0
vRNA Synthesis R-HSA-192814 7.627447e-01 0.118 0 0
Utilization of Ketone Bodies R-HSA-77108 7.627447e-01 0.118 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.627447e-01 0.118 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.627447e-01 0.118 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.627447e-01 0.118 0 0
Suppression of apoptosis R-HSA-9635465 7.627447e-01 0.118 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.627447e-01 0.118 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.627447e-01 0.118 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.627447e-01 0.118 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.645893e-01 0.117 0 0
Ribavirin ADME R-HSA-9755088 7.645893e-01 0.117 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 7.645893e-01 0.117 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 7.645893e-01 0.117 0 0
Platelet homeostasis R-HSA-418346 7.689257e-01 0.114 0 0
G alpha (z) signalling events R-HSA-418597 7.736111e-01 0.111 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.777381e-01 0.109 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.777381e-01 0.109 0 0
ABC transporter disorders R-HSA-5619084 7.783478e-01 0.109 0 0
DAP12 interactions R-HSA-2172127 7.800981e-01 0.108 0 0
RMTs methylate histone arginines R-HSA-3214858 7.800981e-01 0.108 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.818118e-01 0.107 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.818118e-01 0.107 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.818118e-01 0.107 0 0
LDL clearance R-HSA-8964038 7.818118e-01 0.107 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.818118e-01 0.107 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.859241e-01 0.105 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.859241e-01 0.105 0 0
ERKs are inactivated R-HSA-202670 7.859241e-01 0.105 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.859241e-01 0.105 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.859241e-01 0.105 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.859241e-01 0.105 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.859241e-01 0.105 0 0
Sodium/Calcium exchangers R-HSA-425561 7.859241e-01 0.105 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.859241e-01 0.105 0 0
Mitochondrial biogenesis R-HSA-1592230 7.864583e-01 0.104 0 0
Innate Immune System R-HSA-168249 7.907137e-01 0.102 0 0
Signal amplification R-HSA-392518 7.916180e-01 0.101 0 0
eNOS activation R-HSA-203615 7.916180e-01 0.101 0 0
Hyaluronan metabolism R-HSA-2142845 7.916180e-01 0.101 0 0
Neuronal System R-HSA-112316 7.920502e-01 0.101 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.923220e-01 0.101 0 0
IRS-mediated signalling R-HSA-112399 7.959544e-01 0.099 0 0
Termination of O-glycan biosynthesis R-HSA-977068 7.979177e-01 0.098 0 0
Formation of the ureteric bud R-HSA-9830674 7.979177e-01 0.098 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.979177e-01 0.098 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.979177e-01 0.098 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.984031e-01 0.098 0 0
Neddylation R-HSA-8951664 8.033742e-01 0.095 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.039940e-01 0.095 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.039940e-01 0.095 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.039940e-01 0.095 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.065640e-01 0.093 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.068402e-01 0.093 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.068402e-01 0.093 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.068402e-01 0.093 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.068402e-01 0.093 0 0
Conjugation of salicylate with glycine R-HSA-177128 8.068402e-01 0.093 0 0
Signaling by LTK R-HSA-9842663 8.068402e-01 0.093 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.068402e-01 0.093 0 0
Repression of WNT target genes R-HSA-4641265 8.068402e-01 0.093 0 0
Interleukin-35 Signalling R-HSA-8984722 8.068402e-01 0.093 0 0
OAS antiviral response R-HSA-8983711 8.068402e-01 0.093 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.129606e-01 0.090 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.129606e-01 0.090 0 0
Parasite infection R-HSA-9664407 8.163777e-01 0.088 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.163777e-01 0.088 0 0
Leishmania phagocytosis R-HSA-9664417 8.163777e-01 0.088 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.172129e-01 0.088 0 0
Cardiac conduction R-HSA-5576891 8.229317e-01 0.085 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.257138e-01 0.083 0 0
Formation of axial mesoderm R-HSA-9796292 8.257138e-01 0.083 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.257138e-01 0.083 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.257138e-01 0.083 0 0
Interleukin-6 signaling R-HSA-1059683 8.257138e-01 0.083 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.257138e-01 0.083 0 0
GPER1 signaling R-HSA-9634597 8.257362e-01 0.083 0 0
Metal ion SLC transporters R-HSA-425410 8.257362e-01 0.083 0 0
tRNA Aminoacylation R-HSA-379724 8.261727e-01 0.083 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.269944e-01 0.082 0 0
Laminin interactions R-HSA-3000157 8.269944e-01 0.082 0 0
Tight junction interactions R-HSA-420029 8.269944e-01 0.082 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.269944e-01 0.082 0 0
Hyaluronan degradation R-HSA-2160916 8.269944e-01 0.082 0 0
Formation of the nephric duct R-HSA-9830364 8.269944e-01 0.082 0 0
Mitochondrial protein degradation R-HSA-9837999 8.359389e-01 0.078 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.370137e-01 0.077 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.400842e-01 0.076 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.400842e-01 0.076 0 0
Removal of the Flap Intermediate R-HSA-69166 8.427443e-01 0.074 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.427443e-01 0.074 0 0
Hydrolysis of LPC R-HSA-1483115 8.427443e-01 0.074 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.427443e-01 0.074 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.427443e-01 0.074 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.427443e-01 0.074 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.454400e-01 0.073 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.522480e-01 0.069 0 0
Triglyceride biosynthesis R-HSA-75109 8.522480e-01 0.069 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.522480e-01 0.069 0 0
The phototransduction cascade R-HSA-2514856 8.545661e-01 0.068 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.546028e-01 0.068 0 0
Erythropoietin activates RAS R-HSA-9027284 8.581115e-01 0.066 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.581115e-01 0.066 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.581115e-01 0.066 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.581115e-01 0.066 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.581115e-01 0.066 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.581115e-01 0.066 0 0
p38MAPK events R-HSA-171007 8.581115e-01 0.066 0 0
Protein lipoylation R-HSA-9857492 8.581115e-01 0.066 0 0
Transport and metabolism of PAPS R-HSA-174362 8.581115e-01 0.066 0 0
Other semaphorin interactions R-HSA-416700 8.581115e-01 0.066 0 0
Interleukin-2 family signaling R-HSA-451927 8.604368e-01 0.065 0 0
Insulin receptor signalling cascade R-HSA-74751 8.607040e-01 0.065 0 0
Telomere Extension By Telomerase R-HSA-171319 8.635721e-01 0.064 0 0
Insulin receptor recycling R-HSA-77387 8.635721e-01 0.064 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.635721e-01 0.064 0 0
Pyroptosis R-HSA-5620971 8.635721e-01 0.064 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.657815e-01 0.063 0 0
Maturation of spike protein R-HSA-9694548 8.697338e-01 0.061 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.707022e-01 0.060 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.719779e-01 0.059 0 0
Killing mechanisms R-HSA-9664420 8.719779e-01 0.059 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.719779e-01 0.059 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.719779e-01 0.059 0 0
Activation of SMO R-HSA-5635838 8.719779e-01 0.059 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.719779e-01 0.059 0 0
Fructose catabolism R-HSA-70350 8.719779e-01 0.059 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.719779e-01 0.059 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.719779e-01 0.059 0 0
Mitochondrial Uncoupling R-HSA-166187 8.719779e-01 0.059 0 0
Atorvastatin ADME R-HSA-9754706 8.719779e-01 0.059 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.719779e-01 0.059 0 0
Differentiation of T cells R-HSA-9945266 8.719779e-01 0.059 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.740949e-01 0.058 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.740949e-01 0.058 0 0
Scavenging by Class A Receptors R-HSA-3000480 8.784792e-01 0.056 0 0
Kidney development R-HSA-9830369 8.826611e-01 0.054 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.838649e-01 0.054 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.838649e-01 0.054 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.838649e-01 0.054 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.844899e-01 0.053 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.844899e-01 0.053 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.844899e-01 0.053 0 0
Fibronectin matrix formation R-HSA-1566977 8.844899e-01 0.053 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.844899e-01 0.053 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.844899e-01 0.053 0 0
Coenzyme A biosynthesis R-HSA-196783 8.844899e-01 0.053 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.908735e-01 0.050 0 0
Cargo concentration in the ER R-HSA-5694530 8.929286e-01 0.049 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.929286e-01 0.049 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.935911e-01 0.049 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.957797e-01 0.048 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.957797e-01 0.048 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.957797e-01 0.048 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.957797e-01 0.048 0 0
Choline catabolism R-HSA-6798163 8.957797e-01 0.048 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.957797e-01 0.048 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.957797e-01 0.048 0 0
Signaling by Insulin receptor R-HSA-74752 8.979077e-01 0.047 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.979077e-01 0.047 0 0
Dectin-2 family R-HSA-5621480 9.001902e-01 0.046 0 0
Synthesis of PA R-HSA-1483166 9.001902e-01 0.046 0 0
Signaling by WNT in cancer R-HSA-4791275 9.013308e-01 0.045 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.013308e-01 0.045 0 0
COPII-mediated vesicle transport R-HSA-204005 9.015876e-01 0.045 0 0
Amine ligand-binding receptors R-HSA-375280 9.016607e-01 0.045 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.059666e-01 0.043 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.059666e-01 0.043 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.059666e-01 0.043 0 0
PKA activation in glucagon signalling R-HSA-164378 9.059666e-01 0.043 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.059666e-01 0.043 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.059666e-01 0.043 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.059666e-01 0.043 0 0
Triglyceride metabolism R-HSA-8979227 9.123127e-01 0.040 0 0
Regulation of beta-cell development R-HSA-186712 9.123127e-01 0.040 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.123127e-01 0.040 0 0
Integration of energy metabolism R-HSA-163685 9.133916e-01 0.039 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.151584e-01 0.039 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.151584e-01 0.039 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.151584e-01 0.039 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.151584e-01 0.039 0 0
Conjugation of carboxylic acids R-HSA-159424 9.151584e-01 0.039 0 0
Amino Acid conjugation R-HSA-156587 9.151584e-01 0.039 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.151584e-01 0.039 0 0
Methionine salvage pathway R-HSA-1237112 9.151584e-01 0.039 0 0
Specification of the neural plate border R-HSA-9834899 9.151584e-01 0.039 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.151584e-01 0.039 0 0
Parasitic Infection Pathways R-HSA-9824443 9.154101e-01 0.038 0 0
Leishmania infection R-HSA-9658195 9.154101e-01 0.038 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.163192e-01 0.038 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.163192e-01 0.038 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.163192e-01 0.038 0 0
Synthesis of PC R-HSA-1483191 9.207730e-01 0.036 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.216741e-01 0.035 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.229848e-01 0.035 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.229848e-01 0.035 0 0
Aquaporin-mediated transport R-HSA-445717 9.231054e-01 0.035 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.234522e-01 0.035 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.234522e-01 0.035 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.234522e-01 0.035 0 0
Signaling by NODAL R-HSA-1181150 9.234522e-01 0.035 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.234522e-01 0.035 0 0
Creatine metabolism R-HSA-71288 9.234522e-01 0.035 0 0
Synthesis of Ketone Bodies R-HSA-77111 9.234522e-01 0.035 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.280410e-01 0.032 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.291474e-01 0.032 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.291474e-01 0.032 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.291474e-01 0.032 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.291474e-01 0.032 0 0
Regulation of insulin secretion R-HSA-422356 9.297429e-01 0.032 0 0
G-protein activation R-HSA-202040 9.309356e-01 0.031 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.309356e-01 0.031 0 0
Signalling to RAS R-HSA-167044 9.309356e-01 0.031 0 0
Abacavir metabolism R-HSA-2161541 9.309356e-01 0.031 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.309356e-01 0.031 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.309356e-01 0.031 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.309356e-01 0.031 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.348416e-01 0.029 0 0
Triglyceride catabolism R-HSA-163560 9.348416e-01 0.029 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.348416e-01 0.029 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.376879e-01 0.028 0 0
Serine metabolism R-HSA-977347 9.376879e-01 0.028 0 0
Integrin cell surface interactions R-HSA-216083 9.396257e-01 0.027 0 0
PI Metabolism R-HSA-1483255 9.437222e-01 0.025 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.437804e-01 0.025 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.437804e-01 0.025 0 0
Signaling by KIT in disease R-HSA-9669938 9.437804e-01 0.025 0 0
Fructose metabolism R-HSA-5652084 9.437804e-01 0.025 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.437804e-01 0.025 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.437804e-01 0.025 0 0
Formation of the cornified envelope R-HSA-6809371 9.438080e-01 0.025 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.443279e-01 0.025 0 0
Elastic fibre formation R-HSA-1566948 9.449537e-01 0.025 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.486794e-01 0.023 0 0
Ketone body metabolism R-HSA-74182 9.492775e-01 0.023 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.492775e-01 0.023 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.492775e-01 0.023 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.532423e-01 0.021 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.535597e-01 0.021 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.542374e-01 0.020 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.542374e-01 0.020 0 0
Complex III assembly R-HSA-9865881 9.542374e-01 0.020 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.542374e-01 0.020 0 0
Interleukin-6 family signaling R-HSA-6783589 9.542374e-01 0.020 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.560917e-01 0.020 0 0
Paracetamol ADME R-HSA-9753281 9.563160e-01 0.019 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.573647e-01 0.019 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.587125e-01 0.018 0 0
G protein gated Potassium channels R-HSA-1296059 9.587125e-01 0.018 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.587125e-01 0.018 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.587125e-01 0.018 0 0
Intra-Golgi traffic R-HSA-6811438 9.608700e-01 0.017 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.627503e-01 0.016 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.627503e-01 0.016 0 0
Sphingolipid catabolism R-HSA-9845614 9.627503e-01 0.016 0 0
Abacavir ADME R-HSA-2161522 9.627503e-01 0.016 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.627503e-01 0.016 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.661890e-01 0.015 0 0
Signaling by BMP R-HSA-201451 9.663934e-01 0.015 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.663934e-01 0.015 0 0
Synthesis of PE R-HSA-1483213 9.663934e-01 0.015 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.690044e-01 0.014 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.691794e-01 0.014 0 0
RAB geranylgeranylation R-HSA-8873719 9.702540e-01 0.013 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.702540e-01 0.013 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.723160e-01 0.012 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.723160e-01 0.012 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.724820e-01 0.012 0 0
Thyroxine biosynthesis R-HSA-209968 9.726461e-01 0.012 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.726461e-01 0.012 0 0
Glucagon-type ligand receptors R-HSA-420092 9.726461e-01 0.012 0 0
Neurotransmitter release cycle R-HSA-112310 9.741047e-01 0.011 0 0
Neurotransmitter clearance R-HSA-112311 9.753218e-01 0.011 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.762735e-01 0.010 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.777360e-01 0.010 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.799141e-01 0.009 0 0
HS-GAG degradation R-HSA-2024096 9.799141e-01 0.009 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.799141e-01 0.009 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.804955e-01 0.009 0 0
Cardiogenesis R-HSA-9733709 9.818792e-01 0.008 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.836273e-01 0.007 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.836522e-01 0.007 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.836522e-01 0.007 0 0
Heme degradation R-HSA-189483 9.836522e-01 0.007 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.848729e-01 0.007 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.852518e-01 0.006 0 0
Nucleotide biosynthesis R-HSA-8956320 9.863091e-01 0.006 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.865254e-01 0.006 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.875101e-01 0.005 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.875701e-01 0.005 0 0
HS-GAG biosynthesis R-HSA-2022928 9.879970e-01 0.005 0 0
Glycosphingolipid transport R-HSA-9845576 9.879970e-01 0.005 0 0
Gastrulation R-HSA-9758941 9.887700e-01 0.005 0 0
Voltage gated Potassium channels R-HSA-1296072 9.891717e-01 0.005 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.891717e-01 0.005 0 0
Lysine catabolism R-HSA-71064 9.891717e-01 0.005 0 0
Metabolism of folate and pterines R-HSA-196757 9.891717e-01 0.005 0 0
Aspirin ADME R-HSA-9749641 9.894307e-01 0.005 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.902315e-01 0.004 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.902315e-01 0.004 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.902315e-01 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.910837e-01 0.004 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.911876e-01 0.004 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.911876e-01 0.004 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.919973e-01 0.003 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.920502e-01 0.003 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.920502e-01 0.003 0 0
Tryptophan catabolism R-HSA-71240 9.920502e-01 0.003 0 0
Peptide hormone metabolism R-HSA-2980736 9.922219e-01 0.003 0 0
Extracellular matrix organization R-HSA-1474244 9.922582e-01 0.003 0 0
G alpha (s) signalling events R-HSA-418555 9.936248e-01 0.003 0 0
Activation of GABAB receptors R-HSA-991365 9.941638e-01 0.003 0 0
GABA B receptor activation R-HSA-977444 9.941638e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.941638e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.943426e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.943426e-01 0.002 0 0
Complex I biogenesis R-HSA-6799198 9.944254e-01 0.002 0 0
G alpha (q) signalling events R-HSA-416476 9.945048e-01 0.002 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.947352e-01 0.002 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.949093e-01 0.002 0 0
Proteasome assembly R-HSA-9907900 9.952507e-01 0.002 0 0
Surfactant metabolism R-HSA-5683826 9.952507e-01 0.002 0 0
Somitogenesis R-HSA-9824272 9.957157e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.957567e-01 0.002 0 0
O-linked glycosylation of mucins R-HSA-913709 9.964651e-01 0.002 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.965137e-01 0.002 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.971632e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.973151e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.973151e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.974410e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.976513e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.976917e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.976917e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.976917e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.979632e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.983211e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.986215e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.988296e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.989853e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.989884e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.990816e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.990875e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.990875e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.990875e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.991769e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.994291e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.995081e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.995568e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.996414e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.996432e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.996635e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.996787e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996839e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997067e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.997067e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.997355e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997355e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.997395e-01 0.000 0 0
Keratinization R-HSA-6805567 9.997611e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.997630e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.997785e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.997848e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998039e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.998039e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998059e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998174e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.998568e-01 0.000 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.998576e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.998576e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.998716e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.998806e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998956e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.998982e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998992e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999035e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999438e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999441e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999574e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999628e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999837e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999868e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999922e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999944e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999962e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999964e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999979e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999981e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999982e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999986e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999990e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999993e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999994e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999996e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999996e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999997e-01 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways