TBK1
Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Log-Odds: S Sites / S Background
Sites with acceptor types representing >8% and count ≥10 are included
Motif clusters with count ≥ 10 are shown
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| substrate_uniprot | site | source | substrate_genes | site_seq |
|---|---|---|---|---|
| A5A3E0 | S1065 | Sugiyama | POTEF A26C1B | ILASLSTFQQMWISKQEyDEsGPsIVHRKCL__________ |
| A5A3E0 | S1068 | Sugiyama | POTEF A26C1B | SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________ |
| A6NMY6 | S127 | Sugiyama | ANXA2P2 ANX2L2 ANX2P2 LPC2B | AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy |
| O00115 | S57 | Sugiyama | DNASE2 DNASE2A DNL2 | ALRGSGEAAQRGLQYKyLDEssGGWRDGRALINsPEGAVGR |
| O00115 | S58 | Sugiyama | DNASE2 DNASE2A DNL2 | LRGSGEAAQRGLQYKyLDEssGGWRDGRALINsPEGAVGRS |
| O14920 | S177 | GPS6|EPSD | IKBKB IKKB | EQRLIHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQ |
| O14920 | S181 | GPS6|EPSD | IKBKB IKKB | IHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQKyTV |
| O14974 | S903 | Sugiyama | PPP1R12A MBS MYPT1 | QtDsIsRyETssTsAGDRyDsLLGRsGsysYLEERKPYSSR |
| O14974 | Y890 | Sugiyama | PPP1R12A MBS MYPT1 | QsDtEEGsNKKEtQtDsIsRyETssTsAGDRyDsLLGRsGs |
| O15119 | S723 | Sugiyama | TBX3 | sMsLsPKLCAEKEAATsELQsIQRLVSGLEAKPDRsRSASP |
| O15379 | S424 | PSP | HDAC3 | YSRPEAPNEFYDGDHDNDKEsDVEI________________ |
| O43290 | S117 | Sugiyama | SART1 | KRDDGYEAAASSKtssGDAssLSIEETNKLRAKLGLKPLEV |
| O43707 | S796 | Sugiyama | ACTN4 | HFDKDHGGALGPEEFKACLIsLGyDVENDRQGEAEFNRIMS |
| O43852 | S125 | Sugiyama | CALU | IyEDVERQWKGHDLNEDGLVsWEEyKNATYGYVLDDPDPDD |
| O60220 | S94 | Sugiyama | TIMM8A DDP DDP1 TIM8A | SQFILNRLEQTQKSKPVFSEsLsD_________________ |
| O60716 | S230 | Sugiyama | CTNND1 KIAA0384 | PDGysRHyEDGyPGGsDNyGsLsRVtRIEERyRPsMEGyRA |
| O60763 | S880 | Sugiyama | USO1 VDP | LKNEIKALSEERTAIKEQLDssNsTIAILQTEKDKLELEIT |
| O60841 | S222 | Sugiyama | EIF5B IF2 KIAA0741 | KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK |
| O60841 | S66 | Sugiyama | EIF5B IF2 KIAA0741 | KEKKKQDFDEDDILKELEELsLEAQGIKADREtVAVKPTEN |
| O75533 | S322 | Sugiyama | SF3B1 SAP155 | DtPGHGsGWAEtPRtDRGGDsIGEtPtPGAsKRKsRWDEtP |
| O75533 | T316 | Sugiyama | SF3B1 SAP155 | tPKtERDtPGHGsGWAEtPRtDRGGDsIGEtPtPGAsKRKs |
| O75534 | S782 | Sugiyama | CSDE1 D1S155E KIAA0885 NRU UNR | LDDAsAPRLMVLRQPRGPDNsMGFGAERKIRQAGVID____ |
| O94776 | S433 | Sugiyama | MTA2 MTA1L1 PID | ATRGtTEPHSRGHLsRPEAQsLsPyttsANRAKLLAKNRQt |
| O95218 | S181 | Sugiyama | ZRANB2 ZIS ZNF265 | DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR |
| O95757 | S599 | Sugiyama | HSPA4L APG1 HSPH3 OSP94 | sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND |
| O95817 | S165 | Sugiyama | BAG3 BIS | tQPDKQCGQVAAAAAAQPPAsHGPERsQsPAAsDCsssSsS |
| O95817 | S181 | Sugiyama | BAG3 BIS | QPPAsHGPERsQsPAAsDCsssSsSAsLPssGRssLGsHQL |
| O95865 | S245 | SIGNOR|PSP | DDAH2 DDAH G6A NG30 | PGLPGVPPFLLHRGGGDLPNsQEALQKLsDVTLVPVSCSEL |
| O95865 | S253 | SIGNOR|PSP | DDAH2 DDAH G6A NG30 | FLLHRGGGDLPNsQEALQKLsDVTLVPVSCSELEKAGAGLS |
| O95865 | T203 | SIGNOR|PSP | DDAH2 DDAH G6A NG30 | TVVAGSSDAAQKAVRAMAVLtDHPyASLtLPDDAAADCLFL |
| O95865 | T211 | SIGNOR|PSP | DDAH2 DDAH G6A NG30 | AAQKAVRAMAVLtDHPyASLtLPDDAAADCLFLRPGLPGVP |
| P00441 | S106 | Sugiyama | SOD1 | GNVtADKDGVADVsIEDsVIsLsGDHCIIGRTLVVHEKADD |
| P00441 | S99 | Sugiyama | SOD1 | ERHVGDLGNVtADKDGVADVsIEDsVIsLsGDHCIIGRTLV |
| P03372 | S305 | EPSD|PSP | ESR1 ESR NR3A1 | DMRAANLWPsPLMIKRSKKNsLALSLtADQMVSALLDAEPP |
| P04075 | S17 | Sugiyama | ALDOA ALDA | ____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst |
| P04075 | S336 | Sugiyama | ALDOA ALDA | GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs |
| P04075 | S36 | Sugiyama | ALDOA ALDA | LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR |
| P04075 | S39 | Sugiyama | ALDOA ALDA | IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy |
| P04075 | S46 | Sugiyama | ALDOA ALDA | PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA |
| P04083 | S173 | Sugiyama | ANXA1 ANX1 LPC1 | NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG |
| P04406 | S241 | Sugiyama | GAPDH GAPD CDABP0047 OK/SW-cl.12 | IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV |
| P04792 | S82 | Sugiyama | HSPB1 HSP27 HSP28 | AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN |
| P05023 | S217 | Sugiyama | ATP1A1 | DRIPADLRIIsANGCKVDNssLtGESEPQtRsPDFtNENPL |
| P05455 | S225 | Sugiyama | SSB | LRAKQEQEAKQKLEEDAEMKsLEEKIGCLLKFSGDLDDQTC |
| P05455 | S325 | Sugiyama | SSB | VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA |
| P05783 | S86 | Sugiyama | KRT18 CYK18 PIG46 | GIAGGLAGMGGIQNEKETMQsLNDRLAsyLDRVRSLETENR |
| P05783 | S93 | Sugiyama | KRT18 CYK18 PIG46 | GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR |
| P05787 | S280 | Sugiyama | KRT8 CYK8 | IAEVKAQyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDL |
| P05787 | S291 | Sugiyama | KRT8 CYK8 | ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN |
| P05787 | S330 | Sugiyama | KRT8 CYK8 | MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN |
| P05787 | S410 | Sugiyama | KRT8 CYK8 | TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL |
| P06733 | S291 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | IsPDQLADLyKsFIKDyPVVsIEDPFDQDDWGAWQKFtAsA |
| P06733 | S353 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | NEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMVsHRs |
| P06733 | S37 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY |
| P06733 | S40 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK |
| P06733 | T41 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG |
| P06733 | Y44 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK |
| P06748 | S137 | Sugiyama | NPM1 NPM | VAVEEDAEsEDEEEEDVKLLsIsGKRsAPGGGsKVPQKKVK |
| P06748 | S43 | Sugiyama | NPM1 NPM | LKADKDyHFKVDNDENEHQLsLRTVsLGAGAKDELHIVEAE |
| P07195 | S303 | Sugiyama | LDHB | GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt |
| P07355 | S127 | Sugiyama | ANXA2 ANX2 ANX2L4 CAL1H LPC2D | AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy |
| P07355 | S184 | Sugiyama | ANXA2 ANX2 ANX2L4 CAL1H LPC2D | sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK |
| P07737 | S30 | Sugiyama | PFN1 | NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV |
| P07814 | S1473 | Sugiyama | EPRS1 EPRS GLNS PARS QARS QPRS PIG32 | CEDWIKKtTARDQDLEPGAPsMGAKSLCIPFKPLCELQPGA |
| P07814 | S739 | Sugiyama | EPRS1 EPRS GLNS PARS QARS QPRS PIG32 | TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV |
| P07814 | S750 | Sugiyama | EPRS1 EPRS GLNS PARS QARS QPRS PIG32 | APFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVRELKAK |
| P07900 | S476 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | RKKLsELLRyytsAsGDEMVsLKDYCTRMKENQKHIyyItG |
| P07900 | S63 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN |
| P07900 | S641 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD |
| P08195 | S518 | Sugiyama | SLC3A2 MDU1 | DIPGAVSANMTVKGQsEDPGsLLsLFRRLsDQRsKERSLLH |
| P08195 | S521 | Sugiyama | SLC3A2 MDU1 | GAVSANMTVKGQsEDPGsLLsLFRRLsDQRsKERSLLHGDF |
| P08238 | S468 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG |
| P08238 | S470 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs |
| P08238 | S58 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN |
| P08670 | S205 | Sugiyama | VIM | LREKLQEEMLQREEAENtLQsFRQDVDNAsLARLDLERKVE |
| P08670 | S214 | Sugiyama | VIM | LQREEAENtLQsFRQDVDNAsLARLDLERKVEsLQEEIAFL |
| P08670 | S325 | Sugiyama | VIM | NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR |
| P08758 | T10 | Sugiyama | ANXA5 ANX5 ENX2 PP4 | ___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG |
| P09104 | S37 | Sugiyama | ENO2 | NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY |
| P09104 | S40 | Sugiyama | ENO2 | VEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGK |
| P09104 | T41 | Sugiyama | ENO2 | EVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKG |
| P09104 | Y44 | Sugiyama | ENO2 | LyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKGVLK |
| P09234 | S48 | Sugiyama | SNRPC | RKHKENVKDYYQKWMEEQAQsLIDKTTAAFQQGKIPPTPFS |
| P09382 | T58 | Sugiyama | LGALS1 | DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF |
| P09429 | S35 | Sugiyama | HMGB1 HMG1 | syAFFVQtCREEHKKKHPDAsVNFsEFsKKCsERWKtMsAK |
| P09496 | S236 | Sugiyama | CLTA | RLCDFNPKSSKQAKDVSRMRsVLIsLKQAPLVH________ |
| P09496 | S240 | Sugiyama | CLTA | FNPKSSKQAKDVSRMRsVLIsLKQAPLVH____________ |
| P0CG38 | S1065 | Sugiyama | POTEI | ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________ |
| P0CG38 | S1068 | Sugiyama | POTEI | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P0CG39 | S1028 | Sugiyama | POTEJ | ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________ |
| P0CG39 | S1031 | Sugiyama | POTEJ | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P0DPH7 | S48 | Sugiyama | TUBA3C TUBA2 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| P0DPH7 | S54 | Sugiyama | TUBA3C TUBA2 | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| P0DPH7 | T51 | Sugiyama | TUBA3C TUBA2 | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| P10412 | S55 | Sugiyama | H1-4 H1F4 HIST1H1E | AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK |
| P10636 | T30 | PSP | MAPT MAPTL MTBT1 TAU | VMEDHAGTyGLGDRKDQGGytMHQDQEGDtDAGLKEsPLQt |
| P11142 | S40 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA |
| P11586 | T128 | Sugiyama | MTHFD1 MTHFC MTHFD | SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt |
| P11908 | T228 | SIGNOR|PSP | PRPS2 | VGDVKDRVAILVDDMADtCGtICHAADKLLsAGATKVyAIL |
| P13489 | S290 | Sugiyama | RNH1 PRI RNH | AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE |
| P13637 | S207 | Sugiyama | ATP1A3 | DRVPADLRIISAHGCKVDNssLtGESEPQTRSPDCTHDNPL |
| P13639 | S23 | Sugiyama | EEF2 EF2 | NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA |
| P13639 | S38 | Sugiyama | EEF2 EF2 | NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD |
| P13797 | S120 | Sugiyama | PLS3 | KEGICALGGTsELssEGtQHsysEEEKyAFVNWINKALEND |
| P13797 | T117 | Sugiyama | PLS3 | INRKEGICALGGTsELssEGtQHsysEEEKyAFVNWINKAL |
| P13929 | S37 | Sugiyama | ENO3 | NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY |
| P13929 | S40 | Sugiyama | ENO3 | VEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGK |
| P13929 | T41 | Sugiyama | ENO3 | EVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKG |
| P13929 | Y44 | Sugiyama | ENO3 | LHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKGVLK |
| P14209 | S168 | Sugiyama | CD99 MIC2 MIC2X MIC2Y | YQKKKLCFKENAEQGEVDMEsHRNANAEPAVQRtLLEK___ |
| P14314 | S108 | Sugiyama | PRKCSH G19P1 | PSNRVNDGVCDCCDGtDEyNsGVICENtCKEKGRKEREsLQ |
| P14314 | S126 | Sugiyama | PRKCSH G19P1 | yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE |
| P14314 | S168 | Sugiyama | PRKCSH G19P1 | WKKAREEKQKKLIELQAGKKsLEDQVEMLRTVKEEAEKPER |
| P14314 | T469 | Sugiyama | PRKCSH G19P1 | WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt |
| P14618 | S100 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | tHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGPEIR |
| P14618 | S202 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs |
| P14618 | S55 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | IDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMNVARLN |
| P14618 | S97 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | sHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGP |
| P14625 | S523 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | RtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIyFMAG |
| P14625 | S674 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | WsGNMERIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLI |
| P14854 | S63 | Sugiyama | COX6B1 COX6B | AMTAKGGDIsVCEWyQRVYQsLCPtsWVTDWDEQRAEGTFP |
| P14854 | S68 | Sugiyama | COX6B1 COX6B | GGDIsVCEWyQRVYQsLCPtsWVTDWDEQRAEGTFPGKI__ |
| P15531 | S122 | Sugiyama | NME1 NDPKA NM23 | GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy |
| P16402 | S56 | Sugiyama | H1-3 H1F3 HIST1H1D | AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK |
| P16403 | S55 | Sugiyama | H1-2 H1F2 HIST1H1C | AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK |
| P16949 | S46 | Sugiyama | STMN1 C1orf215 LAP18 OP18 | PRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAEERRKsHEA |
| P17066 | S42 | Sugiyama | HSPA6 HSP70B' | VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA |
| P17987 | S551 | Sugiyama | TCP1 CCT1 CCTA | IKLHPESKDDKHGsyEDAVHsGALND_______________ |
| P18615 | S113 | Sugiyama | NELFE RD RDBP | EGKLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLy |
| P18621 | S111 | Sugiyama | RPL17 | LLHMLKNAESNAELKGLDVDsLVIEHIQVNKAPKMRRRTYR |
| P18621 | S5 | Sugiyama | RPL17 | ________________MVRysLDPENPtKsCKSRGSNLRVH |
| P19338 | S458 | Sugiyama | NCL | TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN |
| P19338 | S460 | Sugiyama | NCL | ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST |
| P20648 | S228 | Sugiyama | ATP4A | DRVPADIRILAAQGCKVDNssLtGESEPQTRSPECTHESPL |
| P20810 | S295 | Sugiyama | CAST | QEKKRKVEKDtMsDQALEALsAsLGTRQAEPELDLRsIKEV |
| P20810 | S297 | Sugiyama | CAST | KKRKVEKDtMsDQALEALsAsLGTRQAEPELDLRsIKEVDE |
| P21333 | S1029 | Sugiyama | FLNA FLN FLN1 | VGPSGAAVPCKVEPGLGADNsVVRFLPREEGPYEVEVTYDG |
| P23142 | S51 | Sugiyama | FBLN1 PP213 | VLLEACCADGHRMATHQKDCsLPYATESKECRMVQEQCCHS |
| P23443 | S447 | EPSD|PSP | RPS6KB1 STK14A | sFEPKIRsPRRFIGsPRtPVsPVKFsPGDFWGRGASASTAN |
| P23443 | T444 | EPSD|PSP | RPS6KB1 STK14A | EKFsFEPKIRsPRRFIGsPRtPVsPVKFsPGDFWGRGASAS |
| P23588 | S122 | Sugiyama | EIF4B | NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA |
| P23588 | S207 | Sugiyama | EIF4B | DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR |
| P23921 | S780 | Sugiyama | RRM1 RR1 | KEKVSKEEEEKERNtAAMVCsLENRDECLMCGS________ |
| P24534 | S68 | Sugiyama | EEF1B2 EEF1B EF1B | DLCHALRWYNHIKSYEKEKAsLPGVKKALGKYGPADVEDtt |
| P24752 | S218 | Sugiyama | ACAT1 ACAT MAT | ENTAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPV |
| P25205 | S704 | Sugiyama | MCM3 | DQEQKRKRRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPK |
| P25705 | S53 | Sugiyama | ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM | ARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETGR |
| P25963 | S36 | GPS6|SIGNOR|iPTMNet|EPSD | NFKBIA IKBA MAD3 NFKBI | PRDGLKKERLLDDRHDsGLDsMKDEEyEQMVKELQEIRLEP |
| P26038 | S576 | Sugiyama | MSN | YKtLRQIRQGNTKQRIDEFEsM___________________ |
| P26373 | S109 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | KVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILFPR |
| P26373 | S181 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE |
| P26639 | S522 | Sugiyama | TARS1 TARS | PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP |
| P27348 | S37 | Sugiyama | YWHAQ | ERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKNVVGGRRS |
| P27797 | S52 | Sugiyama | CALR CRTC | GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA |
| P27797 | S53 | Sugiyama | CALR CRTC | WtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDAR |
| P27797 | T34 | Sugiyama | CALR CRTC | LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG |
| P28340 | S1064 | Sugiyama | POLD1 POLD | LNALEERFSRLWTQCQRCQGsLHEDVICTSRDCPIFyMRKK |
| P28715 | S382 | Sugiyama | ERCC5 ERCM2 XPG XPGC | EsENRRQARGRNAPAAVDEGsIsPRtLSAIKRALDDDEDVK |
| P29401 | S295 | Sugiyama | TKT | ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI |
| P29401 | S305 | Sugiyama | TKT | LAtPPQEDAPsVDIANIRMPsLPsyKVGDKIATRKAYGQAL |
| P29692 | S60 | Sugiyama | EEF1D EF1D | ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL |
| P30044 | S168 | Sugiyama | PRDX5 ACR1 SBBI10 | RLLADPTGAFGKEtDLLLDDsLVsIFGNRRLKRFsMVVQDG |
| P30044 | S171 | Sugiyama | PRDX5 ACR1 SBBI10 | ADPTGAFGKEtDLLLDDsLVsIFGNRRLKRFsMVVQDGIVK |
| P30050 | S138 | Sugiyama | RPL12 | HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG |
| P30086 | S104 | Sugiyama | PEBP1 PBP PEBP | WHHFLVVNMKGNDIssGtVLsDyVGsGPPKGtGLHRyVWLV |
| P30086 | S109 | EPSD|PSP | PEBP1 PBP PEBP | VVNMKGNDIssGtVLsDyVGsGPPKGtGLHRyVWLVyEQDR |
| P30086 | S52 | Sugiyama | PEBP1 PBP PEBP | AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD |
| P30101 | S155 | Sugiyama | PDIA3 ERP57 ERP60 GRP58 | ASVPLRTEEEFKKFISDKDAsIVGFFDDsFsEAHsEFLKAA |
| P30740 | S72 | Sugiyama | SERPINB1 ELANH2 MNEI PI2 | AQLSKTFHFNTVEEVHSRFQsLNADINKRGASYILKLANRL |
| P31327 | S1090 | Sugiyama | CPS1 | KNGVKIMGTsPLQIDRAEDRsIFsAVLDELKVAQAPWKAVN |
| P31327 | S1093 | Sugiyama | CPS1 | VKIMGTsPLQIDRAEDRsIFsAVLDELKVAQAPWKAVNTLN |
| P31327 | S564 | Sugiyama | CPS1 | TEDRQLFSDKLNEINEKIAPsFAVEsIEDALKAADTIGyPV |
| P31327 | S569 | Sugiyama | CPS1 | LFSDKLNEINEKIAPsFAVEsIEDALKAADTIGyPVMIRSA |
| P31749 | S473 | SIGNOR|EPSD|PSP | AKT1 PKB RAC | DQDDSMECVDSERRPHFPQFsysAsGtA_____________ |
| P31749 | T308 | EPSD|PSP | AKT1 PKB RAC | IKITDFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGR |
| P31943 | S281 | Sugiyama | HNRNPH1 HNRPH HNRPH1 | GRDLNyCFsGMsDHRyGDGGstFQsttGHCVHMRGLPYRAt |
| P31943 | S285 | Sugiyama | HNRNPH1 HNRPH HNRPH1 | NyCFsGMsDHRyGDGGstFQsttGHCVHMRGLPYRAtENDI |
| P32929 | S56 | Sugiyama | CTH | AVVPPISLSTTFKQGAPGQHsGFEysRsGNPTRNCLEKAVA |
| P34931 | S42 | Sugiyama | HSPA1L | VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA |
| P35269 | S431 | Sugiyama | GTF2F1 RAP74 | GKRVSEMPAAKRLRLDtGPQsLsGKstPQPPsGKttPNsGD |
| P35579 | S1304 | Sugiyama | MYH9 | NVtGLLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQK |
| P35579 | S1308 | Sugiyama | MYH9 | LLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLs |
| P35579 | S169 | Sugiyama | MYH9 | HIyAITDtAyRSMMQDREDQsILCTGESGAGKTENTKKVIQ |
| P35580 | S173 | Sugiyama | MYH10 | HIYAISESAYRCMLQDREDQsILCTGESGAGKTENTKKVIQ |
| P35637 | S346 | Sugiyama | FUS TLS | TDRETGKLKGEAtVsFDDPPsAKAAIDWFDGKEFsGNPIKV |
| P35749 | S173 | Sugiyama | MYH11 KIAA0866 | HIYAIADTAYRSMLQDREDQsILCTGESGAGKTENTKKVIQ |
| P36578 | S66 | Sugiyama | RPL4 RPL1 | KNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHR |
| P36578 | S87 | Sugiyama | RPL4 RPL1 | WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT |
| P36578 | T62 | Sugiyama | RPL4 RPL1 | TNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGG |
| P36578 | T84 | Sugiyama | RPL4 RPL1 | AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP |
| P36871 | S483 | Sugiyama | PGM1 | DKVYtVEKADNFEysDPVDGsIsRNQGLRLIFTDGSRIVFR |
| P37802 | S145 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | VQRTLMNLGGLAVARDDGLFsGDPNWFPKKSKENPRNFsDN |
| P37802 | S163 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG |
| P39019 | S90 | Sugiyama | RPS19 | AGVGsMTKIYGGRQRNGVMPsHFsRGsKsVARRVLQALEGL |
| P39687 | S117 | Sugiyama | ANP32A C15orf1 LANP MAPM PHAP1 | GNKIKDLstIEPLKKLENLKsLDLFNCEVtNLNDyRENVFK |
| P40227 | S205 | Sugiyama | CCT6A CCT6 CCTZ | PIDLFMIEIMEMKHKsEtDtsLIRGLVLDHGARHPDMKKRV |
| P41236 | S24 | Sugiyama | PPP1R2 IPP2 | STAsHRPIKGILKNKtsttssMVAsAEQPRGNVDEELSKKs |
| P42226 | S407 | SIGNOR|EPSD|PSP | STAT6 | LFSASFTLGPGKLPIQLQALsLPLVVIVHGNQDNNAKATIL |
| P42226 | Y641 | SIGNOR | STAT6 | KDEAFRSHYKPEQMGKDGRGyVPATIKMTVERDQPLPTPEL |
| P42345 | S2159 | PSP | MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 | AVPGTYDPNQPIIRIQSIAPsLQVItSKQRPRKLTLMGSNG |
| P42858 | S13 | SIGNOR|PSP | HTT HD IT15 | ________MAtLEKLMKAFEsLKsFQQQQQQQQQQQQQQQQ |
| P42858 | S16 | PSP | HTT HD IT15 | _____MAtLEKLMKAFEsLKsFQQQQQQQQQQQQQQQQQQQ |
| P43243 | S109 | Sugiyama | MATR3 KIAA0723 | IGSRGPLPLSsQHRGDADQAsNILAsFGLsARDLDELSRYP |
| P43243 | S114 | Sugiyama | MATR3 KIAA0723 | PLPLSsQHRGDADQAsNILAsFGLsARDLDELSRYPEDKIt |
| P43243 | S188 | Sugiyama | MATR3 KIAA0723 | EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs |
| P43243 | S195 | Sugiyama | MATR3 KIAA0723 | RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD |
| P43243 | S211 | Sugiyama | MATR3 KIAA0723 | DRGPsLNPVLDyDHGsRsQEsGyyDRMDyEDDRLRDGERCR |
| P43243 | S234 | Sugiyama | MATR3 KIAA0723 | yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG |
| P46776 | S68 | Sugiyama | RPL27A | yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV |
| P46777 | S172 | Sugiyama | RPL5 MSTP030 | RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA |
| P46777 | S176 | Sugiyama | RPL5 MSTP030 | GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR |
| P46937 | S406 | Sugiyama | YAP1 YAP65 | LNsGtyHsRDEstDsGLsMssysVPRtPDDFLNsVDEMDTG |
| P47914 | S142 | Sugiyama | RPL29 | KAKAKAKAKDQTKAQAAAPAsVPAQAPKRtQAPtKAsE___ |
| P48741 | S42 | Sugiyama | HSPA7 HSP70B | VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA |
| P49023 | S83 | Sugiyama | PXN | LDPLDQWQPSSSRFIHQQPQsssPVyGssAKtssVsNPQDs |
| P49327 | S286 | Sugiyama | FASN FAS | GDIQEQLIRSLyQsAGVAPEsFEyIEAHGtGTKVGDPQELN |
| P49588 | S188 | Sugiyama | AARS1 AARS | PGNMKDNFWEMGDtGPCGPCsEIHyDRIGGRDAAHLVNQDD |
| P49589 | S305 | Sugiyama | CARS1 CARS | KLVPEAVGDQKALQEGEGDLsIsADRLsEKRSPNDFALWKA |
| P49790 | S182 | Sugiyama | NUP153 | GFsLVKEIKDstsQHDDDNIsttsGFssRAsDKDITVsKNt |
| P50454 | S139 | Sugiyama | SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 | SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS |
| P50454 | S141 | Sugiyama | SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 | STARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHSKI |
| P50897 | S262 | Sugiyama | PPT1 CLN1 PPT | EWFGFYRsGQAKEtIPLQEtsLytQDRLGLKEMDNAGQLVF |
| P50914 | S16 | Sugiyama | RPL14 | _____MVFRRFVEVGRVAyVsFGPHAGKLVAIVDVIDQNRA |
| P50993 | S215 | Sugiyama | ATP1A2 KIAA0778 | DRVPADLRIISSHGCKVDNssLtGESEPQTRSPEFTHENPL |
| P51116 | S447 | Sugiyama | FXR2 FMR1L2 | GSYGGRGRGRRTGGPAyGPssDVstAsEtEsEKREEPNRAG |
| P51116 | S450 | Sugiyama | FXR2 FMR1L2 | GGRGRGRRTGGPAyGPssDVstAsEtEsEKREEPNRAGPGD |
| P51858 | S165 | Sugiyama | HDGF HMG1L2 | AKEKNEKGALKRRAGDLLEDsPKRPKEAENPEGEEKEAAtL |
| P51858 | S239 | Sugiyama | HDGF HMG1L2 | DEEEEAtKEDAEAPGIRDHEsL___________________ |
| P52630 | T404 | PSP | STAT2 | KtLtPEKGQsQGLIWDFGYLtLVEQRSGGSGKGSNKGPLGV |
| P52907 | S215 | Sugiyama | CAPZA1 | QVHYYEDGNVQLVSHKDVQDsLtVsNEAQtAKEFIKIIENA |
| P53999 | S118 | Sugiyama | SUB1 PC4 RPO2TC1 | PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________ |
| P53999 | S9 | Sugiyama | SUB1 PC4 RPO2TC1 | ____________MPKSKELVsssssGsDsDsEVDKKLKRKK |
| P54652 | S41 | Sugiyama | HSPA2 | VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA |
| P55036 | S358 | Sugiyama | PSMD4 MCB1 | VLENLPGVDPNNEAIRNAMGsLAsQATKDGKKDKKEEDKK_ |
| P55060 | S342 | Sugiyama | CSE1L CAS XPO2 | ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF |
| P55795 | S282 | Sugiyama | HNRNPH2 FTP3 HNRPH2 | RDLNyCFsGMsDHRyGDGGssFQstTGHCVHMRGLPYRATE |
| P55795 | S285 | Sugiyama | HNRNPH2 FTP3 HNRPH2 | NyCFsGMsDHRyGDGGssFQstTGHCVHMRGLPYRATENDI |
| P55854 | S27 | Sugiyama | SUMO3 SMT3A SMT3H1 | KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC |
| P55884 | S185 | Sugiyama | EIF3B EIF3S9 | EEELLGDVLKDRPQEADGIDsVIVVDNVPQVGPDRLEKLKN |
| P56962 | S202 | SIGNOR|EPSD|PSP | STX17 | LSQLVTDFSLLVNSQQEKIDsIADHVNSAAVNVEEGTKNLG |
| P60174 | S212 | Sugiyama | TPI1 TPI | WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV |
| P60228 | S442 | Sugiyama | EIF3E EIF3S6 INT6 | IEKKLNQNSRSEAPNWAtQDsGFy_________________ |
| P60520 | S87 | PSP | GABARAPL2 FLC3A GEF2 | RIQLPSEKAIFLFVDKTVPQssLTMGQLYEKEKDEDGFLYV |
| P60520 | S88 | PSP | GABARAPL2 FLC3A GEF2 | IQLPSEKAIFLFVDKTVPQssLTMGQLYEKEKDEDGFLYVA |
| P60709 | S365 | Sugiyama | ACTB | ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________ |
| P60709 | S368 | Sugiyama | ACTB | sLstFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P60709 | S52 | Sugiyama | ACTB | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P60709 | S60 | Sugiyama | ACTB | HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD |
| P60709 | Y53 | Sugiyama | ACTB | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH |
| P60891 | T228 | SIGNOR|PSP | PRPS1 | VGDVKDRVAILVDDMADtCGtICHAADKLLsAGATRVyAIL |
| P61163 | T248 | Sugiyama | ACTR1A CTRN1 | PQKDETLETEKAQyyLPDGstIEIGPSRFRAPELLFRPDLI |
| P61204 | S147 | Sugiyama | ARF3 | KQDLPNAMNAAEITDKLGLHsLRHRNWYIQATCATSGDGLY |
| P61247 | S263 | Sugiyama | RPS3A FTE1 MFTL | GDEtGAKVERADGyEPPVQEsV___________________ |
| P61604 | S64 | Sugiyama | HSPE1 | AtVVAVGsGsKGKGGEIQPVsVKVGDKVLLPEyGGtKVVLD |
| P61758 | S157 | Sugiyama | VBP1 PFDN3 | IDEAQALLEKNLSTATKNLDsLEEDLDFLRDQFTtTEVNMA |
| P61769 | S75 | Sugiyama | B2M CDABP0092 HDCMA22P | IEVDLLKNGERIEKVEHsDLsFsKDWSFYLLYYTEFTPTEK |
| P61956 | S28 | Sugiyama | SUMO2 SMT3B SMT3H2 | EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC |
| P61978 | S401 | Sugiyama | HNRNPK HNRPK | GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI |
| P61978 | S75 | Sugiyama | HNRNPK HNRPK | GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE |
| P61981 | S38 | Sugiyama | YWHAG | ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS |
| P62249 | S9 | Sugiyama | RPS16 | ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN |
| P62258 | S148 | Sugiyama | YWHAE | YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP |
| P62266 | S45 | Sugiyama | RPS23 | KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA |
| P62277 | S12 | Sugiyama | RPS13 | _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD |
| P62277 | S14 | Sugiyama | RPS13 | _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK |
| P62736 | S54 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P62736 | S62 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P62736 | Y55 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P62857 | S39 | Sugiyama | RPS28 | GRtGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtLL |
| P62899 | S15 | Sugiyama | RPL31 | ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG |
| P62899 | Y108 | Sugiyama | RPL31 | LSRKRNEDEDsPNKLytLVtyVPVttFKNLQtVNVDEN___ |
| P62917 | S130 | Sugiyama | RPL8 | GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL |
| P62917 | S138 | Sugiyama | RPL8 | EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI |
| P62917 | T135 | Sugiyama | RPL8 | CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK |
| P62917 | Y133 | Sugiyama | RPL8 | VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG |
| P62979 | S134 | Sugiyama | RPS27A UBA80 UBCEP1 | IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE |
| P63104 | S28 | Sugiyama | YWHAZ | QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy |
| P63220 | S31 | Sugiyama | RPS21 | LYVPRKCSASNRIIGAKDHAsIQMNVAEVDKVTGRFNGQFK |
| P63220 | S68 | Sugiyama | RPS21 | GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____ |
| P63261 | S365 | Sugiyama | ACTG1 ACTG | ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________ |
| P63261 | S368 | Sugiyama | ACTG1 ACTG | sLstFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P63261 | S52 | Sugiyama | ACTG1 ACTG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P63261 | S60 | Sugiyama | ACTG1 ACTG | HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD |
| P63261 | Y53 | Sugiyama | ACTG1 ACTG | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH |
| P63267 | S53 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P63267 | S61 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P63267 | Y54 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P67809 | S314 | Sugiyama | YBX1 NSEP1 YB1 | NPKPQDGKETKAADPPAENssAPEAEQGGAE__________ |
| P68032 | S54 | Sugiyama | ACTC1 ACTC | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68032 | S62 | Sugiyama | ACTC1 ACTC | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P68032 | Y55 | Sugiyama | ACTC1 ACTC | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P68133 | S54 | Sugiyama | ACTA1 ACTA | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68133 | S62 | Sugiyama | ACTA1 ACTA | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P68133 | Y55 | Sugiyama | ACTA1 ACTA | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P68363 | S48 | Sugiyama | TUBA1B | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| P68363 | S54 | Sugiyama | TUBA1B | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| P68363 | T51 | Sugiyama | TUBA1B | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| P78417 | S23 | Sugiyama | GSTO1 GSTTLP28 | GESARsLGKGsAPPGPVPEGsIRIySMRFCPFAERTRLVLK |
| P83731 | S38 | Sugiyama | RPL24 | GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK |
| P83731 | S7 | Sugiyama | RPL24 | ______________MKVELCsFsGyKIYPGHGRRYARTDGK |
| P84077 | S147 | Sugiyama | ARF1 | KQDLPNAMNAAEITDKLGLHsLRHRNWYIQATCATSGDGLY |
| P84098 | S37 | Sugiyama | RPL19 | CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV |
| P98170 | S430 | PSP | XIAP API3 BIRC4 IAP3 | LVADLVNAQKDSMQDESSQTsLQKEISTEEQLRRLQEEKLC |
| Q00839 | S59 | Sugiyama | HNRNPU C1orf199 HNRPU SAFA U21.1 | QAALDDEEAGGRPAMEPGNGsLDLGGDsAGRSGAGLEQEAA |
| Q01094 | S332 | EPSD|PSP | E2F1 RBBP3 | PSQEVTSEEENRAtDsAtIVsPPPssPPssLttDPSQSLLS |
| Q01844 | S274 | Sugiyama | EWSR1 EWS | YSQQSSSYGQQSsFRQDHPssMGVyGQESGGFSGPGENRSM |
| Q04206 | S536 | GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP | RELA NFKB3 | APLGAPGLPNGLLsGDEDFSsIADMDFsALLSQISS_____ |
| Q05682 | S129 | Sugiyama | CALD1 CAD CDM | KRLQEALERQKEFDPtItDAsLsLPsRRMQNDTAENETTEK |
| Q05682 | S131 | Sugiyama | CALD1 CAD CDM | LQEALERQKEFDPtItDAsLsLPsRRMQNDTAENETTEKEE |
| Q05682 | S58 | Sugiyama | CALD1 CAD CDM | ARERRRRARQERLRQKQEEEsLGQVTDQVEVNAQNsVPDEE |
| Q06830 | S126 | Sugiyama | PRDX1 PAGA PAGB TDPX2 | SDPKRtIAQDyGVLKADEGIsFRGLFIIDDKGILRQItVND |
| Q07020 | S62 | Sugiyama | RPL18 | tFNQVVLKRLFMSRtNRPPLsLsRMIRKMKLPGRENKtAVV |
| Q07157 | S1065 | Sugiyama | TJP1 ZO1 | YVEKQAsRDLEQPtyRyEsssytDQFsRNYEHRLRYEDRVP |
| Q07955 | S182 | Sugiyama | SRSF1 ASF SF2 SF2P33 SFRS1 OK/SW-cl.3 | FVRKEDMTYAVRKLDNTKFRsHEGEtAyIRVKVDGPRsPsy |
| Q09161 | S33 | Sugiyama | NCBP1 CBP80 NCBP | GQPHKRRKtsDANEtEDHLEsLICKVGEKSACSLESNLEGL |
| Q12792 | S55 | Sugiyama | TWF1 PTK9 | EQLVIGSYSQPSDSWDKDyDsFVLPLLEDKQPCYILFRLDS |
| Q12965 | S1014 | Sugiyama | MYO1E MYO1C | RPPLPRQQstssDRVsQtPEsLDFLKVPDQGAAGVRRQTTS |
| Q13263 | S681 | Sugiyama | TRIM28 KAP1 RNF96 TIF1B | GEEWSCSLCHVLPDLKEEDGsLsLDGADstGVVAKLsPANQ |
| Q13263 | S784 | Sugiyama | TRIM28 KAP1 RNF96 TIF1B | DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK |
| Q13428 | S1376 | Sugiyama | TCOF1 | ARtPRSKKKKKLGAGEGGEAsVsPEKtsttSKGKAKRDKAS |
| Q13435 | S171 | Sugiyama | SF3B2 SAP145 | QQQAALLMQQEERAKQQGDHsLKEHELLEQQKRAAVLLEQE |
| Q13439 | S1187 | Sugiyama | GOLGA4 | DKRKVSELTSKLKTTDEEFQsLKsSHEKSNKSLEDKSLEFK |
| Q13501 | S366 | PSP | SQSTM1 ORCA OSIL | VDPstGELQsLQMPEsEGPssLDPsQEGPtGLKEAALyPHL |
| Q13501 | S403 | SIGNOR|EPSD|PSP | SQSTM1 ORCA OSIL | yPHLPPEADPRLIESLsQMLsMGFsDEGGWLTRLLQTKNyD |
| Q13561 | S203 | Sugiyama | DCTN2 DCTN50 | ATKNSKGGSGGKttGtPPDssLVtyELHsRPEQDKFSQAAK |
| Q13568 | S158 | SIGNOR|EPSD|PSP | IRF5 | FGAGEEEEEEEELQRMLPSLsLTEDVKWPPTLQPPTLRPPT |
| Q13568 | S293 | SIGNOR|EPSD|PSP | IRF5 | RLFYSQLEATQEQVELFGPIsLEQVRFPsPEDIPSDKQRFy |
| Q14152 | S1028 | Sugiyama | EIF3A EIF3S10 KIAA0139 | NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP |
| Q14152 | S584 | Sugiyama | EIF3A EIF3S10 KIAA0139 | EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV |
| Q14152 | S988 | Sugiyama | EIF3A EIF3S10 KIAA0139 | PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN |
| Q14192 | S13 | Sugiyama | FHL2 DRAL SLIM3 | ________MTERFDCHHCNEsLFGKKYILREESPYCVVCFE |
| Q14192 | S238 | Sugiyama | FHL2 DRAL SLIM3 | AKKCAGCTNPISGLGGtKyIsFEERQWHNDCFNCKKCsLsL |
| Q14247 | S113 | Sugiyama | CTTN EMS1 | DRMDKsAVGHEyQSKLsKHCsQVDsVRGFGGKFGVQMDRVD |
| Q14247 | S117 | Sugiyama | CTTN EMS1 | KsAVGHEyQSKLsKHCsQVDsVRGFGGKFGVQMDRVDQsAV |
| Q14247 | S156 | Sugiyama | CTTN EMS1 | AVGFEyQGKtEKHAsQKDyssGFGGKyGVQADRVDKsAVGF |
| Q14247 | S331 | Sugiyama | CTTN EMS1 | GVQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKtsNIR |
| Q14247 | S432 | Sugiyama | CTTN EMS1 | EERLPssPVyEDAAsFKAELsyRGPVsGtEPEPVysMEAAD |
| Q14257 | S207 | Sugiyama | RCN2 ERC55 | TEFVIQEALEEHDKNGDGFVsLEEFLGDyRWDPTANEDPEW |
| Q14432 | T311 | Sugiyama | PDE3A | RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR |
| Q14444 | S200 | Sugiyama | CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 | EEELSLLDEFyKLVDPERDMsLRLNEQYEHASIHLWDLLEG |
| Q14653 | S173 | EPSD|PSP | IRF3 | PDPGPPSLAVAPEPCPQPLRsPsLDNPtPFPNLGPsENPLK |
| Q14653 | S175 | EPSD|PSP | IRF3 | PGPPSLAVAPEPCPQPLRsPsLDNPtPFPNLGPsENPLKRL |
| Q14653 | S385 | GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP | IRF3 | VKVVPTCLRALVEMARVGGAssLENtVDLHIsNsHPLsLts |
| Q14653 | S386 | GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP | IRF3 | KVVPTCLRALVEMARVGGAssLENtVDLHIsNsHPLsLtsD |
| Q14653 | S396 | SIGNOR|EPSD|PSP | IRF3 | VEMARVGGAssLENtVDLHIsNsHPLsLtsDQYKAYLQDLV |
| Q14653 | S398 | SIGNOR|EPSD|PSP | IRF3 | MARVGGAssLENtVDLHIsNsHPLsLtsDQYKAYLQDLVEG |
| Q14653 | S402 | SIGNOR|EPSD|PSP | IRF3 | GGAssLENtVDLHIsNsHPLsLtsDQYKAYLQDLVEGMDFQ |
| Q14653 | S405 | GPS6|SIGNOR|EPSD|PSP | IRF3 | ssLENtVDLHIsNsHPLsLtsDQYKAYLQDLVEGMDFQGPG |
| Q14653 | T404 | GPS6|SIGNOR|EPSD|PSP | IRF3 | AssLENtVDLHIsNsHPLsLtsDQYKAYLQDLVEGMDFQGP |
| Q14669 | S312 | PSP | TRIP12 KIAA0045 ULF | PSGLQAKLASLRKSTKKRsEsPPAELPSLRRSTRQKTTGSC |
| Q14684 | S422 | Sugiyama | RRP1B KIAA0179 | KKKKKHHLQPENPGPGGAAPsLEQNRGREPEASGLKALKAR |
| Q14847 | S194 | Sugiyama | LASP1 MLN50 | PQQQPVAQsYGGyKEPAAPVsIQRsAPGGGGKRYRAVYDYS |
| Q14966 | S558 | Sugiyama | ZNF638 NP220 ZFML | RSRSPYRIRNPFRGsPKCFRsVsPERMSRRSVRSSDRKKAL |
| Q14980 | S1789 | Sugiyama | NUMA1 NMP22 NUMA | sLEsLyFtPIPARsQAPLEssLDsLGDVFLDsGRKtRSARR |
| Q14980 | S1792 | Sugiyama | NUMA1 NMP22 NUMA | sLyFtPIPARsQAPLEssLDsLGDVFLDsGRKtRSARRRtt |
| Q15025 | S122 | SIGNOR|PSP | TNIP1 KIAA0113 NAF1 | APACPSDKPAPVQKPPSSGTssEFEVVTPEEQNSPESSSHA |
| Q15025 | S123 | SIGNOR|PSP | TNIP1 KIAA0113 NAF1 | PACPSDKPAPVQKPPSSGTssEFEVVTPEEQNSPESSSHAN |
| Q15056 | S110 | Sugiyama | EIF4H KIAA0038 WBSCR1 WSCR1 | DEVDsLKEALtyDGALLGDRsLRVDIAEGRKQDKGGFGFRK |
| Q15056 | S14 | Sugiyama | EIF4H KIAA0038 WBSCR1 WSCR1 | _______MADFDtyDDRAyssFGGGRGsRGsAGGHGsRSQK |
| Q15056 | S94 | Sugiyama | EIF4H KIAA0038 WBSCR1 WSCR1 | RDKDTDKFKGFCyVEFDEVDsLKEALtyDGALLGDRsLRVD |
| Q15185 | S72 | Sugiyama | PTGES3 P23 TEBP | EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE |
| Q4V328 | S666 | Sugiyama | GRIPAP1 KIAA1167 | EELVLsEMNsPSRtQtGDsssIssFsYREILREKEssAVPA |
| Q58FF6 | S34 | Sugiyama | HSP90AB4P | IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN |
| Q58FF7 | S58 | Sugiyama | HSP90AB3P HSP90BC | IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN |
| Q58FF8 | S58 | Sugiyama | HSP90AB2P HSP90BB | IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN |
| Q5SW79 | S865 | Sugiyama | CEP170 FAM68A KAB KIAA0470 | sPNIPIELIPHINKQTsstPssLALtsAsRIRERsEsLDPD |
| Q5T035 | S66 | Sugiyama | FAM120A2P C9orf129 | LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI |
| Q5T3I0 | S272 | Sugiyama | GPATCH4 GPATC4 | VsDEREGTTKGNEKEDAAGtsGLGELNSREQtNQSLRKGKK |
| Q6EEV6 | S28 | Sugiyama | SUMO4 SMT3H4 | EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC |
| Q6GYQ0 | S1279 | Sugiyama | RALGAPA1 GARNL1 KIAA0884 TULIP1 | PDVAVSQFTDVKELIIKTVLssARDEPsGPARCVALCSLGI |
| Q6GYQ0 | S1280 | Sugiyama | RALGAPA1 GARNL1 KIAA0884 TULIP1 | DVAVSQFTDVKELIIKTVLssARDEPsGPARCVALCSLGIW |
| Q6GYQ0 | S1286 | Sugiyama | RALGAPA1 GARNL1 KIAA0884 TULIP1 | FTDVKELIIKTVLssARDEPsGPARCVALCSLGIWICEELV |
| Q6P996 | S724 | Sugiyama | PDXDC1 KIAA0251 | QKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQItL |
| Q6P996 | S786 | Sugiyama | PDXDC1 KIAA0251 | AFQKGVPHPEDDHsQVEGPEsLR__________________ |
| Q6PEY2 | S48 | Sugiyama | TUBA3E | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q6PEY2 | S54 | Sugiyama | TUBA3E | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| Q6PEY2 | T51 | Sugiyama | TUBA3E | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| Q6S8J3 | S1065 | Sugiyama | POTEE A26C1A POTE2 | ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________ |
| Q6S8J3 | S1068 | Sugiyama | POTEE A26C1A POTE2 | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| Q6UXH1 | S295 | Sugiyama | CRELD2 UNQ185/PRO211 | KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY |
| Q71RC2 | S394 | Sugiyama | LARP4 PP13296 | RVKPQFRssGGsEHstEGsVsLGDGQLNRYSSRNFPAERHN |
| Q71U36 | S48 | Sugiyama | TUBA1A TUBA3 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q71U36 | S54 | Sugiyama | TUBA1A TUBA3 | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| Q71U36 | T51 | Sugiyama | TUBA1A TUBA3 | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| Q7RTV0 | S53 | Sugiyama | PHF5A | CDSyVRPCTLVRICDECNyGsyQGRCVICGGPGVSDAyyCK |
| Q7Z406 | S193 | Sugiyama | MYH14 KIAA2034 FP17425 | HVYAVTEGAYRSMLQDREDQsILCTGESGAGKTENTKKVIQ |
| Q7Z417 | S592 | Sugiyama | NUFIP2 KIAA1321 PIG1 | sPQVLGSILKsGttsEsGALsLEPsHIGDLQKADtssQGAL |
| Q7Z417 | S596 | Sugiyama | NUFIP2 KIAA1321 PIG1 | LGSILKsGttsEsGALsLEPsHIGDLQKADtssQGALVFLS |
| Q7Z434 | S442 | PSP | MAVS IPS1 KIAA1271 VISA | GVLASQVDsPFsGCFEDLAIsASTSLGMGPCHGPEENEYKs |
| Q7Z4S6 | S708 | Sugiyama | KIF21A KIAA1708 KIF2 | KIRDTQLERDQVLQNLGsVEsysEEKAKKVRSEYEKKLQAM |
| Q7Z4V5 | S181 | Sugiyama | HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 | ALKMsVSKRARKASSDLDQAsVsPSEEENSESSsESEKTsD |
| Q7Z4V5 | S395 | Sugiyama | HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 | REDDEPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKK |
| Q86U44 | S67 | PSP | METTL3 MTA70 | RsDsPVPtAPtsGGPKPstAsAVPELATDPELEKKLLHHLS |
| Q86UE4 | S306 | Sugiyama | MTDH AEG1 LYRIC | WNEKSVKLssQIsAGEEKWNsVsPAsAGKRKtEPSAWsQDt |
| Q86V81 | S145 | Sugiyama | ALYREF ALY BEF THOC4 | LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ |
| Q86WR0 | S188 | Sugiyama | CCDC25 | KREKEEMKKKREMDELRSYssLMKVENMSSNQDGNDsDEFM |
| Q86WV6 | S358 | GPS6|SIGNOR|EPSD|PSP | STING1 ERIS MITA STING TMEM173 | KEEVTVGSLKTSAVPSTsTMsQEPELLIsGMEKPLPLRTDF |
| Q86WV6 | S366 | PSP | STING1 ERIS MITA STING TMEM173 | LKTSAVPSTsTMsQEPELLIsGMEKPLPLRTDFS_______ |
| Q8IUC6 | S210 | PSP | TICAM1 PRVTIRB TRIF | QGCSLRSTGsPASLASNLEIsQsPTMPFLSLHRSPHGPSKL |
| Q8N122 | S877 | PSP | RPTOR KIAA1303 RAPTOR | tQsAPAsPtNKGVHIHQAGGsPPAsstssssLtNDVAKQPV |
| Q8N6T3 | S346 | Sugiyama | ARFGAP1 ARF1GAP | QSFWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWEV |
| Q8N6T3 | S348 | Sugiyama | ARFGAP1 ARF1GAP | FWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWEVWG |
| Q8NBJ7 | S256 | Sugiyama | SUMF2 PSEC0171 UNQ1968/PRO4500 | EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG |
| Q8NBS9 | S285 | Sugiyama | TXNDC5 TLP46 UNQ364/PRO700 | LLWFRDGKKVDQYKGKRDLEsLREyVEsQLQRTETGATETV |
| Q8NHV4 | S397 | Sugiyama | NEDD1 | sINTDtLSKEtDsGKNQDFssFDDtGKssLGDMFsPIRDDA |
| Q8TAM6 | S280 | Sugiyama | ERMN KIAA1189 | TISYRKIRKGNTKQRIDEFEsMMHL________________ |
| Q8TD19 | S13 | Sugiyama | NEK9 KIAA1995 NEK8 NERCC | ________MsVLGEYERHCDsINSDFGSEsGGCGDssPGPS |
| Q8TEV9 | S402 | EPSD|PSP | SMCR8 | MVEKQESIPSKPsQDRPPsssLEECPIPKVLIsVGsYKSsV |
| Q8TEV9 | T796 | EPSD|PSP | SMCR8 | DFQKWKLIGLQRVAsPAGAGtLHALSRYSRYTSILDLDNKT |
| Q8WU90 | S351 | Sugiyama | ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730 | DIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLsEAs |
| Q8WUD4 | S149 | Sugiyama | CCDC12 | KRTQRAIAELIRERLKGQEDsLAsAVDAATEQKtCDsD___ |
| Q8WVJ2 | S142 | Sugiyama | NUDCD2 | LTLERFQKENPGFDFsGAEIsGNytKGGPDFsNLEK_____ |
| Q8WWI1 | S704 | Sugiyama | LMO7 FBX20 FBXO20 KIAA0858 | KKRLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEM |
| Q8WWM7 | S563 | Sugiyama | ATXN2L A2D A2LG A2LP A2RP | EELRKFGAQFKLQPsssPENsLDPFPPRILKEEPKGKEKEV |
| Q8WXH0 | S6392 | Sugiyama | SYNE2 KIAA1011 NUA | EIQTDsWRKRGESEEPssPQsLCHLVAPGHERSGCETPVSV |
| Q92576 | S299 | Sugiyama | PHF3 KIAA0244 | KPVGsPLFKFsDKEEHEQNDsISGKTGETVVEEMIATRKVE |
| Q92688 | S117 | Sugiyama | ANP32B APRIL PHAPI2 | GNKLKDIstLEPLKKLECLKsLDLFNCEVtNLNDyREsVFK |
| Q92764 | S103 | Sugiyama | KRT35 HHA5 HKA5 KRTHA5 | GGGGWFGEGILTGNEKETMQsLNDRLAGYLEKVRQLEQENA |
| Q92804 | S295 | Sugiyama | TAF15 RBP56 TAF2N | TDKDTGKPKGEAtVsFDDPPsAKAAIDWFDGKEFHGNIIKV |
| Q92844 | S228 | Sugiyama | TANK ITRAF TRAF2 | sITsVtPRGLCRDEEDtsFEsLsKFNVKFPPMDNDSTFLHS |
| Q92985 | S471 | EPSD|PSP | IRF7 | VKLEPWLCRVHLEGTQREGVssLDSSsLsLCLsSANsLYDD |
| Q92985 | S472 | EPSD|PSP | IRF7 | KLEPWLCRVHLEGTQREGVssLDSSsLsLCLsSANsLYDDI |
| Q92985 | S477 | GPS6|EPSD|PSP | IRF7 | LCRVHLEGTQREGVssLDSSsLsLCLsSANsLYDDIECFLM |
| Q92985 | S479 | GPS6|EPSD|PSP | IRF7 | RVHLEGTQREGVssLDSSsLsLCLsSANsLYDDIECFLMEL |
| Q93045 | S80 | Sugiyama | STMN2 SCG10 SCGN10 | PPsPISEAPRTLAsPKKKDLsLEEIQKKLEAAEERRKsQEA |
| Q969G3 | S317 | Sugiyama | SMARCE1 BAF57 | RKRQEEREKEAAEQAERsQssIVPEEEQAANKGEEKKDDEN |
| Q96AE4 | S52 | Sugiyama | FUBP1 | KDALQRARQIAAKIGGDAGtsLNsNDyGyGGQKRPLEDGDQ |
| Q96AQ6 | S147 | SIGNOR|PSP | PBXIP1 HPIP | PQSLPSTPKAAWIREEGRCsssDDDTDVDMEGLRRRRGREA |
| Q96B36 | S211 | Sugiyama | AKT1S1 PRAS40 | WGFKEKRtEARssDEENGPPssPDLDRIAAsMRALVLREAE |
| Q96CT7 | S122 | Sugiyama | CCDC124 | DtLRRDHQLREAPDTAEKAKsHLEVPLEENVNRRVLEEGsV |
| Q96CT7 | S141 | Sugiyama | CCDC124 | KsHLEVPLEENVNRRVLEEGsVEARTIEDAIAVLsVAEEAA |
| Q96CV9 | S177 | GPS6|EPSD|PSP | OPTN FIP2 GLC1E HIP7 HYPL NRP | LLGIVSELQLKLNssGssEDsFVEIRMAEGEAEGsVKEIKH |
| Q96CV9 | S473 | EPSD|PSP | OPTN FIP2 GLC1E HIP7 HYPL NRP | KQEEDLETMTILRAQMEVYCsDFHAERAAREKIHEEKEQLA |
| Q96CV9 | S513 | EPSD|PSP | OPTN FIP2 GLC1E HIP7 HYPL NRP | ALQLAVLLKENDAFEDGGRQsLMEMQsRHGARtsDsDQQAy |
| Q96FA3 | S293 | EPSD|PSP | PELI1 PRISM | QEINAARPQCPVGFNtLAFPsMKRKDVVDEKQPWVYLNCGH |
| Q96FA3 | S76 | EPSD|PSP | PELI1 PRISM | TVHIACTPQAAKAIsNKDQHsIsYtLsRAQtVVVEYTHDSN |
| Q96FA3 | T288 | EPSD|PSP | PELI1 PRISM | LEALRQEINAARPQCPVGFNtLAFPsMKRKDVVDEKQPWVY |
| Q96FA3 | T80 | EPSD|PSP | PELI1 PRISM | ACTPQAAKAIsNKDQHsIsYtLsRAQtVVVEYTHDSNTDMF |
| Q96HE7 | S143 | Sugiyama | ERO1A ERO1L UNQ434/PRO865 | EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD |
| Q99497 | S57 | Sugiyama | PARK7 | GLAGKDPVQCsRDVVICPDAsLEDAKKEGPyDVVVLPGGNL |
| Q99584 | S62 | Sugiyama | S100A13 | VTQQLPHLLKDVGSLDEKMKsLDVNQDSELKFNEyWRLIGE |
| Q99613 | S154 | Sugiyama | EIF3C EIF3S8 | NAKALSTLRQKIRKyNRDFEsHItSyKQNPEQsADEDAEKN |
| Q99613 | S865 | Sugiyama | EIF3C EIF3S8 | HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF |
| Q99614 | S155 | Sugiyama | TTC1 TPR1 | AESSYSRALEMCPSCFQKERsILFSNRAAARMKQDKKEMAI |
| Q99614 | S281 | Sugiyama | TTC1 TPR1 | PFGLstENFQIKQDsstGsysINFVQNPNNNR_________ |
| Q99848 | S270 | Sugiyama | EBNA1BP2 EBP2 | FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN |
| Q9BQE3 | S48 | Sugiyama | TUBA1C TUBA6 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q9BQE3 | S54 | Sugiyama | TUBA1C TUBA6 | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| Q9BQE3 | T51 | Sugiyama | TUBA1C TUBA6 | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| Q9BQE9 | S120 | Sugiyama | BCL7B | VYQLKVDsstNssPsPQQsEsLsPAHtsDFRtDDsQPPTLG |
| Q9BRV8 | S133 | SIGNOR|EPSD|PSP | SIKE1 SIKE | LQLMVAKKAVDAEPVLKAHQsHsAEIESQIDRICEMGEVMR |
| Q9BRV8 | S185 | SIGNOR|EPSD|PSP | SIKE1 SIKE | KIQEKLAQLELENKELRELLsIssEsLQARKENsMDTASQA |
| Q9BRV8 | S187 | SIGNOR|EPSD|PSP | SIKE1 SIKE | QEKLAQLELENKELRELLsIssEsLQARKENsMDTASQAIK |
| Q9BRV8 | S188 | SIGNOR|EPSD|PSP | SIKE1 SIKE | EKLAQLELENKELRELLsIssEsLQARKENsMDTASQAIK_ |
| Q9BRV8 | S190 | SIGNOR|EPSD|PSP | SIKE1 SIKE | LAQLELENKELRELLsIssEsLQARKENsMDTASQAIK___ |
| Q9BRV8 | S198 | SIGNOR|EPSD|PSP | SIKE1 SIKE | KELRELLsIssEsLQARKENsMDTASQAIK___________ |
| Q9BRZ2 | T442 | PSP | TRIM56 RNF109 | EKAQTTREEGAQtLEEDRAQtPHEDGGPQPHRGGRPNKKKK |
| Q9BTC0 | S352 | Sugiyama | DIDO1 C20orf158 DATF1 KIAA0333 | TADQQEAKWRPGDADGTDCTsIGtIEQKSSEDQGIKGRIEK |
| Q9BTD8 | S372 | Sugiyama | RBM42 | KPEKLKRCIRtAAGSSWEDPsLLEWDADDFRIFCGDLGNEV |
| Q9BTD8 | T362 | Sugiyama | RBM42 | EPLGEDKKKGKPEKLKRCIRtAAGSSWEDPsLLEWDADDFR |
| Q9BX40 | S349 | Sugiyama | LSM14B C20orf40 FAM61B RAP55B | SSRRTTWAEERKLNtEtFGVsGRFLRGRSSRGGFRGGRGNG |
| Q9BXS6 | S363 | Sugiyama | NUSAP1 ANKT BM-037 PRO0310 | TtEAtQtPVsNKKPVFDLKAsLsRPLNyEPHKGKLKPWGQS |
| Q9BXW4 | S93 | PSP | MAP1LC3C | IRSRMVLRATEAFYLLVNNKsLVsMSATMAEIYRDYKDEDG |
| Q9BXW4 | S96 | PSP | MAP1LC3C | RMVLRATEAFYLLVNNKsLVsMSATMAEIYRDYKDEDGFVY |
| Q9BY44 | S526 | Sugiyama | EIF2A CDA02 MSTP004 MSTP089 | sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA |
| Q9BYW2 | S968 | Sugiyama | SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069 | NRRNNGLSGKCLQEAQEEGNsILPERRGRPEISLDERGEGG |
| Q9BYX7 | S365 | Sugiyama | POTEKP ACTBL3 FKSG30 | ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________ |
| Q9BYX7 | S368 | Sugiyama | POTEKP ACTBL3 FKSG30 | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| Q9C005 | S50 | Sugiyama | DPY30 | IVENEKINAEKSSKQKVDLQsLPTRAYLDQTVVPILLQGLA |
| Q9C0C2 | S1174 | Sugiyama | TNKS1BP1 KIAA1741 TAB182 | ttAGsVDWTDQLGLRNLEVssCVGsGGssEAREsAVGQMGW |
| Q9C0C2 | S936 | Sugiyama | TNKS1BP1 KIAA1741 TAB182 | GRyssQDADEQDWEFQKRDVsLGTyGSRAAEPQEQEFGKSA |
| Q9H0L4 | S563 | Sugiyama | CSTF2T KIAA0689 | IQGGGIQGASKQGGsQPssFsPGQsQVtPQDQEKAALIMQV |
| Q9H2U2 | S309 | Sugiyama | PPA2 HSPC124 | NCTNVQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVW |
| Q9H2U2 | S313 | Sugiyama | PPA2 HSPC124 | VQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLG |
| Q9H2U2 | S315 | Sugiyama | PPA2 HSPC124 | ISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLGK_ |
| Q9H3Q1 | S309 | Sugiyama | CDC42EP4 BORG4 CEP4 | AAPsPGsARSMGSHTTRDSSsLssCtsGILEERsPAFRGPD |
| Q9H4F8 | S65 | Sugiyama | SMOC1 | LHCSRTQPKPICASDGRSYEsMCEYQRAKCRDPTLGVVHRG |
| Q9H5H4 | S116 | Sugiyama | ZNF768 | PsPEFAPRsPEsDSQsPEFEsQSPRyEPQsPGYEPRsPGYE |
| Q9H765 | S17 | PSP | ASB8 PP14212 | ____MSSSMWYIMQSIQSKYsLSERLIRTIAAIRsFPHDNV |
| Q9H788 | S124 | Sugiyama | SH2D4A PPP1R38 SH2A | LKAEQEAEEPRKTHsEEFTNsLKTKsQyHDLQAPDNQQtKD |
| Q9HCE1 | S992 | Sugiyama | MOV10 KIAA1631 | tsGPHsHDyLPQEREGEGGLsLQVEPEWRNEL_________ |
| Q9NQC3 | S778 | Sugiyama | RTN4 KIAA0886 NOGO My043 SP1507 | QKQDETVMLVKESLTETSFEsMIEyENKEKLSALPPEGGKP |
| Q9NQX3 | S262 | Sugiyama | GPHN GPH KIAA1385 | AKIPDSIISRGVQVLPRDTAsLsttPsEsPRAQAtsRLstA |
| Q9NUU7 | S59 | Sugiyama | DDX19A DDX19L | KTSTTAEKTDEEEKEDRAAQsLLNKLIRSNLVDNtNQVEVL |
| Q9NX58 | S32 | Sugiyama | LYAR PNAS-5 | sVKKIQVEKHVSVCRNCECLsCIDCGKDFWGDDYKNHVKCI |
| Q9NZB2 | S417 | Sugiyama | FAM120A C9orf10 KIAA0183 OSSA | LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI |
| Q9UBR2 | S78 | Sugiyama | CTSZ | SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST |
| Q9UHB6 | S704 | Sugiyama | LIMA1 EPLIN SREBP3 PP624 | ADsDEDDNsFLKQQsPQEPKsLNWssFVDNtFAEEFTTQNQ |
| Q9UHB6 | S709 | Sugiyama | LIMA1 EPLIN SREBP3 PP624 | DDNsFLKQQsPQEPKsLNWssFVDNtFAEEFTTQNQKsQDV |
| Q9UHD2 | S151 | Sugiyama | TBK1 NAK | IVHRDIKPGNIMRVIGEDGQsVyKLtDFGAARELEDDEQFV |
| Q9UHD2 | S172 | GPS6|EPSD|PSP|Sugiyama | TBK1 NAK | VyKLtDFGAARELEDDEQFVsLyGtEEyLHPDMYERAVLRK |
| Q9UHD2 | S243 | Sugiyama | TBK1 NAK | PFEGPRRNKEVMYKIItGKPsGAIsGVQKAENGPIDWSGDM |
| Q9UHD2 | S247 | Sugiyama | TBK1 NAK | PRRNKEVMYKIItGKPsGAIsGVQKAENGPIDWSGDMPVSC |
| Q9UHD2 | S348 | Sugiyama | TBK1 NAK | SYNTATIFHELVyKQTKIISsNQELIyEGRRLVLEPGRLAQ |
| Q9UHD2 | S383 | Sugiyama | TBK1 NAK | PGRLAQHFPKTTEENPIFVVsREPLNtIGLIyEKISLPKVH |
| Q9UHD2 | S413 | Sugiyama | TBK1 NAK | IyEKISLPKVHPRYDLDGDAsMAKAITGVVCYACRIASTLL |
| Q9UHD2 | S531 | Sugiyama | TBK1 NAK | sQGTIETSLQDIDSRLsPGGsLADAWAHQEGTHPKDRNVEK |
| Q9UHD2 | S716 | Sugiyama | TBK1 NAK | EMEGVVKELAENNHILERFGsLtMDGGLRNVDCL_______ |
| Q9UHD2 | T156 | Sugiyama | TBK1 NAK | IKPGNIMRVIGEDGQsVyKLtDFGAARELEDDEQFVsLyGt |
| Q9UHD2 | T176 | Sugiyama | TBK1 NAK | tDFGAARELEDDEQFVsLyGtEEyLHPDMYERAVLRKDHQK |
| Q9UHD2 | T239 | Sugiyama | TBK1 NAK | LPFRPFEGPRRNKEVMYKIItGKPsGAIsGVQKAENGPIDW |
| Q9UHD2 | T389 | Sugiyama | TBK1 NAK | HFPKTTEENPIFVVsREPLNtIGLIyEKISLPKVHPRYDLD |
| Q9UHD2 | T718 | Sugiyama | TBK1 NAK | EGVVKELAENNHILERFGsLtMDGGLRNVDCL_________ |
| Q9UHD2 | Y174 | Sugiyama | TBK1 NAK | KLtDFGAARELEDDEQFVsLyGtEEyLHPDMYERAVLRKDH |
| Q9UII2 | S39 | Sugiyama | ATP5IF1 ATPI ATPIF1 | TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF |
| Q9UKV3 | S551 | Sugiyama | ACIN1 ACINUS KIAA0670 | LKIEELALAKGITEECLKQPsLEQKEGRRAsHtLLPSHRLK |
| Q9UMR2 | S60 | Sugiyama | DDX19B DBP5 DDX19 TDBP | KTNANAEKTDEEEKEDRAAQsLLNKLIRSNLVDNtNQVEVL |
| Q9UPQ0 | S204 | Sugiyama | LIMCH1 KIAA1102 | DsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVVLRG |
| Q9UQ35 | S1152 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | sPEQsRFQsDsssyPtVDsNsLLGQsRLETAESKEKMALPP |
| Q9UQ35 | S1458 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | RsRsGssPGLRDGsGtPsRHsLsGssPGMKDIPRtPSRGRs |
| Q9UQ35 | S864 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | VKsGtPPRQGsItsPQANEQsVtPQRRsCFEssPDPELKsR |
| Q9UQ35 | S990 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | sGsssPDtKVKPEtPPRQsHsGsIsPyPKVKAQtPPGPsLs |
| Q9UQ35 | S992 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | sssPDtKVKPEtPPRQsHsGsIsPyPKVKAQtPPGPsLsGs |
| Q9Y3F4 | S230 | Sugiyama | STRAP MAWD UNRIP | SAVSLDPIKsFEAPAtINsAsLHPEKEFLVAGGEDFKLyKy |
| Q9Y3F4 | S260 | Sugiyama | STRAP MAWD UNRIP | AGGEDFKLyKyDyNsGEELEsyKGHFGPIHCVRFSPDGELy |
| Q9Y450 | S65 | Sugiyama | HBS1L HBS1 KIAA1038 | RDKPsVEPVEEyDyEDLKEssNsVsNHQLSGFDQARLYsCL |
| Q9Y5K6 | S80 | Sugiyama | CD2AP | ETEFKDDSLPIKRERHGNVAsLVQRIstyGLPAGGIQPHPQ |
| Q9Y5L4 | S57 | Sugiyama | TIMM13 TIM13B TIMM13A TIMM13B | ELLQRMTDKCFRKCIGKPGGsLDNSEQKCIAMCMDRyMDAW |
| Q9Y5S9 | S56 | Sugiyama | RBM8A RBM8 HSPC114 MDS014 | KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF |
| Q9Y5X1 | S116 | Sugiyama | SNX9 SH3PX1 SH3PXD3A | SNNHQVGSGNDPWSAWSASKsGNWESsEGWGAQPEGAGAQR |
| Q9Y696 | S31 | Sugiyama | CLIC4 | KEEDKEPLIELFVKAGsDGEsIGNCPFSQRLFMILWLKGVV |
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| Apoptotic execution phase | R-HSA-75153 | 1.400030e-10 | 9.854 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 2.319174e-10 | 9.635 | 0 | 0 |
| Cell Cycle | R-HSA-1640170 | 9.448283e-08 | 7.025 | 0 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 2.351791e-07 | 6.629 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 1.753992e-06 | 5.756 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 4.583350e-06 | 5.339 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 8.455121e-06 | 5.073 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 1.382289e-05 | 4.859 | 0 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 1.582798e-05 | 4.801 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 2.128366e-05 | 4.672 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 2.567576e-05 | 4.590 | 0 | 0 |
| M Phase | R-HSA-68886 | 2.589845e-05 | 4.587 | 0 | 0 |
| Signal Transduction | R-HSA-162582 | 3.118606e-05 | 4.506 | 1 | 0 |
| Attenuation phase | R-HSA-3371568 | 3.799163e-05 | 4.420 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 3.657650e-05 | 4.437 | 0 | 0 |
| HSF1 activation | R-HSA-3371511 | 4.199439e-05 | 4.377 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 4.606399e-05 | 4.337 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 4.779880e-05 | 4.321 | 0 | 0 |
| Cellular response to heat stress | R-HSA-3371556 | 5.908618e-05 | 4.229 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 7.654614e-05 | 4.116 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 8.961296e-05 | 4.048 | 1 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 9.929403e-05 | 4.003 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 1.286830e-04 | 3.890 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 1.275496e-04 | 3.894 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 1.713784e-04 | 3.766 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | R-HSA-9825892 | 1.905522e-04 | 3.720 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 2.236863e-04 | 3.650 | 1 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 3.017837e-04 | 3.520 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 3.420090e-04 | 3.466 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 3.636477e-04 | 3.439 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 4.714633e-04 | 3.327 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 5.194186e-04 | 3.284 | 1 | 1 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 5.209612e-04 | 3.283 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 5.307356e-04 | 3.275 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 5.650705e-04 | 3.248 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 6.359124e-04 | 3.197 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 6.359124e-04 | 3.197 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 6.755348e-04 | 3.170 | 1 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 7.490319e-04 | 3.125 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 7.868506e-04 | 3.104 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 8.262563e-04 | 3.083 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 9.027702e-04 | 3.044 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 9.737628e-04 | 3.012 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 9.957134e-04 | 3.002 | 1 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 1.000640e-03 | 3.000 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 1.087730e-03 | 2.963 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 1.125964e-03 | 2.948 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 1.127298e-03 | 2.948 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 1.695362e-03 | 2.771 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 1.695362e-03 | 2.771 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 1.695362e-03 | 2.771 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 1.695362e-03 | 2.771 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 1.695362e-03 | 2.771 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 1.695362e-03 | 2.771 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 1.695362e-03 | 2.771 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 1.695362e-03 | 2.771 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 1.695362e-03 | 2.771 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 1.695362e-03 | 2.771 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 1.695362e-03 | 2.771 | 0 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 1.488221e-03 | 2.827 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 1.616382e-03 | 2.791 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 1.416932e-03 | 2.849 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 1.488221e-03 | 2.827 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 1.616382e-03 | 2.791 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 1.824608e-03 | 2.739 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 1.872354e-03 | 2.728 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 1.875521e-03 | 2.727 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 1.891164e-03 | 2.723 | 0 | 0 |
| SMAC (DIABLO) binds to IAPs | R-HSA-111463 | 1.997560e-03 | 2.700 | 0 | 0 |
| SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | R-HSA-111464 | 1.997560e-03 | 2.700 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 1.977175e-03 | 2.704 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 2.001678e-03 | 2.699 | 0 | 0 |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | R-HSA-190840 | 2.026038e-03 | 2.693 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 2.147979e-03 | 2.668 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 2.147979e-03 | 2.668 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 2.218327e-03 | 2.654 | 1 | 1 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 2.288133e-03 | 2.641 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 2.508940e-03 | 2.601 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 2.530841e-03 | 2.597 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 2.628610e-03 | 2.580 | 0 | 0 |
| Transport of connexons to the plasma membrane | R-HSA-190872 | 2.713853e-03 | 2.566 | 0 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 2.766141e-03 | 2.558 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | R-HSA-8939246 | 2.803575e-03 | 2.552 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 3.218197e-03 | 2.492 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 3.315304e-03 | 2.479 | 0 | 0 |
| SMAC, XIAP-regulated apoptotic response | R-HSA-111469 | 3.521787e-03 | 2.453 | 0 | 0 |
| RUNX1 regulates expression of components of tight junctions | R-HSA-8935964 | 3.521787e-03 | 2.453 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 3.404848e-03 | 2.468 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 3.358024e-03 | 2.474 | 1 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 3.756213e-03 | 2.425 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 3.789044e-03 | 2.421 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 3.789044e-03 | 2.421 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 3.789044e-03 | 2.421 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 3.789044e-03 | 2.421 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 3.789044e-03 | 2.421 | 1 | 1 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 3.840419e-03 | 2.416 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 4.127366e-03 | 2.384 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 4.165846e-03 | 2.380 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 4.102380e-03 | 2.387 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 4.176813e-03 | 2.379 | 0 | 0 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 4.176813e-03 | 2.379 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 4.258641e-03 | 2.371 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 4.258641e-03 | 2.371 | 0 | 0 |
| CASP8 activity is inhibited | R-HSA-5218900 | 4.263079e-03 | 2.370 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 4.312273e-03 | 2.365 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 4.343891e-03 | 2.362 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 4.519781e-03 | 2.345 | 0 | 0 |
| Post-chaperonin tubulin folding pathway | R-HSA-389977 | 4.635690e-03 | 2.334 | 0 | 0 |
| Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 4.970238e-03 | 2.304 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 4.919618e-03 | 2.308 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 4.885684e-03 | 2.311 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 5.057531e-03 | 2.296 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 5.186359e-03 | 2.285 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 5.308628e-03 | 2.275 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 5.390837e-03 | 2.268 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 5.497905e-03 | 2.260 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 6.218733e-03 | 2.206 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 6.222902e-03 | 2.206 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 6.191568e-03 | 2.208 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 6.095000e-03 | 2.215 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 6.098353e-03 | 2.215 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 6.276345e-03 | 2.202 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 6.348789e-03 | 2.197 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 6.714084e-03 | 2.173 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 6.745138e-03 | 2.171 | 0 | 0 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 7.544185e-03 | 2.122 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 7.544185e-03 | 2.122 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 7.544185e-03 | 2.122 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 7.329543e-03 | 2.135 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 7.329543e-03 | 2.135 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 7.524043e-03 | 2.124 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 7.857880e-03 | 2.105 | 0 | 0 |
| CLEC7A (Dectin-1) induces NFAT activation | R-HSA-5607763 | 7.980664e-03 | 2.098 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 8.178593e-03 | 2.087 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 8.449936e-03 | 2.073 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 8.624822e-03 | 2.064 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 9.258715e-03 | 2.033 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 9.258715e-03 | 2.033 | 0 | 0 |
| Polo-like kinase mediated events | R-HSA-156711 | 8.939494e-03 | 2.049 | 0 | 0 |
| ChREBP activates metabolic gene expression | R-HSA-163765 | 8.756782e-03 | 2.058 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 9.143296e-03 | 2.039 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 9.579129e-03 | 2.019 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 9.579129e-03 | 2.019 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 1.083329e-02 | 1.965 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 1.083329e-02 | 1.965 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 1.120974e-02 | 1.950 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 1.120974e-02 | 1.950 | 0 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 1.149342e-02 | 1.940 | 0 | 0 |
| IRS activation | R-HSA-74713 | 1.189998e-02 | 1.924 | 0 | 0 |
| Regulation by c-FLIP | R-HSA-3371378 | 1.282677e-02 | 1.892 | 0 | 0 |
| Dimerization of procaspase-8 | R-HSA-69416 | 1.282677e-02 | 1.892 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 1.284224e-02 | 1.891 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 1.202581e-02 | 1.920 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 1.284224e-02 | 1.891 | 0 | 0 |
| Kinesins | R-HSA-983189 | 1.271277e-02 | 1.896 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 1.300793e-02 | 1.886 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 1.354198e-02 | 1.868 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 1.382306e-02 | 1.859 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 1.403823e-02 | 1.853 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 1.410873e-02 | 1.851 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 1.438736e-02 | 1.842 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 1.464271e-02 | 1.834 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 1.612215e-02 | 1.793 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 1.512182e-02 | 1.820 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 1.512182e-02 | 1.820 | 0 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 1.618837e-02 | 1.791 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 1.539435e-02 | 1.813 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 1.629714e-02 | 1.788 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 1.595650e-02 | 1.797 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 1.618837e-02 | 1.791 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 1.579456e-02 | 1.801 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 1.627605e-02 | 1.788 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 1.595650e-02 | 1.797 | 0 | 0 |
| Membrane Trafficking | R-HSA-199991 | 1.630070e-02 | 1.788 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 1.645142e-02 | 1.784 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 1.693326e-02 | 1.771 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 1.710142e-02 | 1.767 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 1.713461e-02 | 1.766 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 1.769277e-02 | 1.752 | 0 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 1.794710e-02 | 1.746 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 1.794710e-02 | 1.746 | 0 | 0 |
| GLI proteins bind promoters of Hh responsive genes to promote transcription | R-HSA-5635851 | 1.844836e-02 | 1.734 | 0 | 0 |
| Phosphorylation of Emi1 | R-HSA-176417 | 1.844836e-02 | 1.734 | 0 | 0 |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | 1.844836e-02 | 1.734 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 1.844836e-02 | 1.734 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 1.844836e-02 | 1.734 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 1.881984e-02 | 1.725 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 1.881984e-02 | 1.725 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 2.147645e-02 | 1.668 | 0 | 0 |
| Caspase activation via extrinsic apoptotic signalling pathway | R-HSA-5357769 | 2.026644e-02 | 1.693 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 1.973446e-02 | 1.705 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 2.102773e-02 | 1.677 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 1.958540e-02 | 1.708 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 1.938201e-02 | 1.713 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 2.057553e-02 | 1.687 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 2.252818e-02 | 1.647 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 2.328351e-02 | 1.633 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 2.379005e-02 | 1.624 | 0 | 0 |
| Apoptosis induced DNA fragmentation | R-HSA-140342 | 2.426078e-02 | 1.615 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 2.441264e-02 | 1.612 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 2.548598e-02 | 1.594 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 2.548598e-02 | 1.594 | 0 | 0 |
| Formation of editosomes by ADAR proteins | R-HSA-77042 | 2.608320e-02 | 1.584 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 2.608320e-02 | 1.584 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 2.608320e-02 | 1.584 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 2.608320e-02 | 1.584 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 2.608320e-02 | 1.584 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 2.608320e-02 | 1.584 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 2.644592e-02 | 1.578 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 2.644592e-02 | 1.578 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 2.644592e-02 | 1.578 | 0 | 0 |
| Regulation of NFE2L2 gene expression | R-HSA-9818749 | 2.686697e-02 | 1.571 | 0 | 0 |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | R-HSA-2980767 | 2.686697e-02 | 1.571 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in WNT signaling | R-HSA-8939256 | 2.686697e-02 | 1.571 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 2.686697e-02 | 1.571 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 2.700315e-02 | 1.569 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 2.735561e-02 | 1.563 | 0 | 0 |
| Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 3.043122e-02 | 1.517 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 3.139290e-02 | 1.503 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 2.813953e-02 | 1.551 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 3.129058e-02 | 1.505 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 2.851897e-02 | 1.545 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 3.159908e-02 | 1.500 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 3.188384e-02 | 1.496 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 3.210399e-02 | 1.493 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 3.214578e-02 | 1.493 | 0 | 0 |
| p38MAPK events | R-HSA-171007 | 3.294512e-02 | 1.482 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 3.306890e-02 | 1.481 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 3.329047e-02 | 1.478 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 3.343777e-02 | 1.476 | 0 | 0 |
| Regulation of HMOX1 expression and activity | R-HSA-9707587 | 3.964371e-02 | 1.402 | 0 | 0 |
| TNFR1-mediated ceramide production | R-HSA-5626978 | 3.964371e-02 | 1.402 | 0 | 0 |
| RUNX2 regulates genes involved in differentiation of myeloid cells | R-HSA-8941333 | 3.964371e-02 | 1.402 | 0 | 0 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | 3.964371e-02 | 1.402 | 0 | 0 |
| RUNX1 regulates estrogen receptor mediated transcription | R-HSA-8931987 | 3.724863e-02 | 1.429 | 0 | 0 |
| Activation of PUMA and translocation to mitochondria | R-HSA-139915 | 3.724863e-02 | 1.429 | 0 | 0 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | 3.724863e-02 | 1.429 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 3.724863e-02 | 1.429 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 3.861272e-02 | 1.413 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 3.861272e-02 | 1.413 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 3.861272e-02 | 1.413 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 3.861272e-02 | 1.413 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 3.596753e-02 | 1.444 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 3.597223e-02 | 1.444 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 3.861272e-02 | 1.413 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 4.010983e-02 | 1.397 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 3.617801e-02 | 1.442 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 3.971786e-02 | 1.401 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 3.776375e-02 | 1.423 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 3.597223e-02 | 1.444 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 3.502922e-02 | 1.456 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 3.502922e-02 | 1.456 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 3.523130e-02 | 1.453 | 0 | 0 |
| Cation-coupled Chloride cotransporters | R-HSA-426117 | 3.724863e-02 | 1.429 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 3.561231e-02 | 1.448 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 4.033686e-02 | 1.394 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 4.041852e-02 | 1.393 | 0 | 0 |
| Caspase activation via Death Receptors in the presence of ligand | R-HSA-140534 | 4.053319e-02 | 1.392 | 0 | 0 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | R-HSA-399955 | 4.053319e-02 | 1.392 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 4.053319e-02 | 1.392 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 4.053319e-02 | 1.392 | 0 | 0 |
| Cytochrome c-mediated apoptotic response | R-HSA-111461 | 4.077128e-02 | 1.390 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 4.080521e-02 | 1.389 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 4.164087e-02 | 1.380 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 4.164087e-02 | 1.380 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 4.214525e-02 | 1.375 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 4.214525e-02 | 1.375 | 0 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 4.394901e-02 | 1.357 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 4.419292e-02 | 1.355 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 4.443139e-02 | 1.352 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 4.517651e-02 | 1.345 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 4.520220e-02 | 1.345 | 0 | 0 |
| Signalling to RAS | R-HSA-167044 | 4.587697e-02 | 1.338 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 4.898697e-02 | 1.310 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 5.106399e-02 | 1.292 | 0 | 0 |
| Regulation of IFNG signaling | R-HSA-877312 | 5.106399e-02 | 1.292 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 5.212256e-02 | 1.283 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 5.249968e-02 | 1.280 | 0 | 0 |
| SMAD2/3 MH2 Domain Mutants in Cancer | R-HSA-3315487 | 5.415410e-02 | 1.266 | 0 | 0 |
| SMAD4 MH2 Domain Mutants in Cancer | R-HSA-3311021 | 5.415410e-02 | 1.266 | 0 | 0 |
| Loss of Function of SMAD4 in Cancer | R-HSA-3304347 | 5.415410e-02 | 1.266 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 5.759972e-02 | 1.240 | 0 | 0 |
| RUNX2 regulates chondrocyte maturation | R-HSA-8941284 | 5.759972e-02 | 1.240 | 0 | 0 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | R-HSA-9659787 | 6.274156e-02 | 1.202 | 0 | 0 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | R-HSA-9661069 | 6.274156e-02 | 1.202 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 5.879414e-02 | 1.231 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 5.879414e-02 | 1.231 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 5.396183e-02 | 1.268 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 5.757658e-02 | 1.240 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 6.282231e-02 | 1.202 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 5.396183e-02 | 1.268 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 5.831236e-02 | 1.234 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 5.799579e-02 | 1.237 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 5.415410e-02 | 1.266 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 5.757658e-02 | 1.240 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 5.831236e-02 | 1.234 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 6.400418e-02 | 1.194 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 6.274156e-02 | 1.202 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 6.353271e-02 | 1.197 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 5.757658e-02 | 1.240 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 6.464614e-02 | 1.189 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 6.515102e-02 | 1.186 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 6.745900e-02 | 1.171 | 0 | 0 |
| FOXO-mediated transcription of cell death genes | R-HSA-9614657 | 6.949865e-02 | 1.158 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 6.966902e-02 | 1.157 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 7.215928e-02 | 1.142 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 7.215928e-02 | 1.142 | 0 | 0 |
| Gap junction assembly | R-HSA-190861 | 7.332592e-02 | 1.135 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 7.523799e-02 | 1.124 | 0 | 0 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 7.872011e-02 | 1.104 | 0 | 0 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | 7.872011e-02 | 1.104 | 0 | 0 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | 7.872011e-02 | 1.104 | 0 | 0 |
| PTK6 Regulates Cell Cycle | R-HSA-8849470 | 7.872011e-02 | 1.104 | 0 | 0 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | 7.872011e-02 | 1.104 | 0 | 0 |
| Aryl hydrocarbon receptor signalling | R-HSA-8937144 | 7.872011e-02 | 1.104 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 8.019938e-02 | 1.096 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 8.019938e-02 | 1.096 | 0 | 0 |
| Josephin domain DUBs | R-HSA-5689877 | 8.031125e-02 | 1.095 | 0 | 0 |
| Defective RIPK1-mediated regulated necrosis | R-HSA-9693928 | 8.031125e-02 | 1.095 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 8.031125e-02 | 1.095 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 8.054436e-02 | 1.094 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 8.125385e-02 | 1.090 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 8.210590e-02 | 1.086 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 8.239436e-02 | 1.084 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 8.247373e-02 | 1.084 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 8.328283e-02 | 1.079 | 0 | 0 |
| mRNA Editing: A to I Conversion | R-HSA-75064 | 8.891655e-02 | 1.051 | 0 | 0 |
| Stimulation of the cell death response by PAK-2p34 | R-HSA-211736 | 8.891655e-02 | 1.051 | 0 | 0 |
| RUNX3 regulates RUNX1-mediated transcription | R-HSA-8951911 | 8.891655e-02 | 1.051 | 0 | 0 |
| C6 deamination of adenosine | R-HSA-75102 | 8.891655e-02 | 1.051 | 0 | 0 |
| Signaling by RAS GAP mutants | R-HSA-9753510 | 8.891655e-02 | 1.051 | 0 | 0 |
| Mitotic Metaphase/Anaphase Transition | R-HSA-68881 | 8.891655e-02 | 1.051 | 0 | 0 |
| G2/M DNA replication checkpoint | R-HSA-69478 | 1.026884e-01 | 0.988 | 0 | 0 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 9.846057e-02 | 1.007 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 9.846057e-02 | 1.007 | 0 | 0 |
| RHOBTB3 ATPase cycle | R-HSA-9706019 | 9.846057e-02 | 1.007 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 9.020304e-02 | 1.045 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 9.020304e-02 | 1.045 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 1.059148e-01 | 0.975 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 9.404641e-02 | 1.027 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 1.078523e-01 | 0.967 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 1.078523e-01 | 0.967 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 9.471919e-02 | 1.024 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 9.471919e-02 | 1.024 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 1.070020e-01 | 0.971 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 1.070020e-01 | 0.971 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 9.149196e-02 | 1.039 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 9.651455e-02 | 1.015 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 9.527731e-02 | 1.021 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 9.149196e-02 | 1.039 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 1.026884e-01 | 0.988 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 1.000674e-01 | 1.000 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 8.927915e-02 | 1.049 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 9.651455e-02 | 1.015 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 9.020304e-02 | 1.045 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 9.136185e-02 | 1.039 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 9.174028e-02 | 1.037 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 1.067135e-01 | 0.972 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 9.471919e-02 | 1.024 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 9.174028e-02 | 1.037 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 1.053841e-01 | 0.977 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 9.821133e-02 | 1.008 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 8.892748e-02 | 1.051 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 1.114804e-01 | 0.953 | 1 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 1.144648e-01 | 0.941 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 1.150867e-01 | 0.939 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 1.163754e-01 | 0.934 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 1.163754e-01 | 0.934 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 1.163754e-01 | 0.934 | 0 | 0 |
| Deletions in the AXIN1 gene destabilize the destruction complex | R-HSA-5467345 | 1.165812e-01 | 0.933 | 0 | 0 |
| Defective translocation of RB1 mutants to the nucleus | R-HSA-9661070 | 1.165812e-01 | 0.933 | 0 | 0 |
| Deletions in the AMER1 gene destabilize the destruction complex | R-HSA-5467343 | 1.165812e-01 | 0.933 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 1.166210e-01 | 0.933 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 1.169412e-01 | 0.932 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 1.176418e-01 | 0.929 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 1.183166e-01 | 0.927 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 1.183298e-01 | 0.927 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 1.183298e-01 | 0.927 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 1.183298e-01 | 0.927 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 1.200801e-01 | 0.921 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 1.200931e-01 | 0.920 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 1.203234e-01 | 0.920 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 1.217161e-01 | 0.915 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 1.217871e-01 | 0.914 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 1.225958e-01 | 0.912 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 1.226375e-01 | 0.911 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 1.228090e-01 | 0.911 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 1.228710e-01 | 0.911 | 1 | 1 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 1.228710e-01 | 0.911 | 0 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 1.232434e-01 | 0.909 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 1.238281e-01 | 0.907 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 1.283025e-01 | 0.892 | 0 | 0 |
| STAT6-mediated induction of chemokines | R-HSA-3249367 | 1.284304e-01 | 0.891 | 1 | 1 |
| FasL/ CD95L signaling | R-HSA-75157 | 1.284304e-01 | 0.891 | 0 | 0 |
| MET interacts with TNS proteins | R-HSA-8875513 | 1.284304e-01 | 0.891 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 1.287696e-01 | 0.890 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 1.287696e-01 | 0.890 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 1.289544e-01 | 0.890 | 0 | 0 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | 1.291416e-01 | 0.889 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 1.291416e-01 | 0.889 | 0 | 0 |
| PTK6 Expression | R-HSA-8849473 | 1.291416e-01 | 0.889 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose | R-HSA-9031528 | 1.291416e-01 | 0.889 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 1.291416e-01 | 0.889 | 0 | 0 |
| Regulation of gap junction activity | R-HSA-191650 | 1.711164e-01 | 0.767 | 0 | 0 |
| TLR3-mediated TICAM1-dependent programmed cell death | R-HSA-9013957 | 1.711164e-01 | 0.767 | 0 | 0 |
| Inhibition of TSC complex formation by PKB | R-HSA-165181 | 1.711164e-01 | 0.767 | 0 | 0 |
| NFE2L2 regulating ER-stress associated genes | R-HSA-9818035 | 1.711164e-01 | 0.767 | 0 | 0 |
| TGFBR1 KD Mutants in Cancer | R-HSA-3656532 | 1.711164e-01 | 0.767 | 0 | 0 |
| Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | R-HSA-69200 | 1.711164e-01 | 0.767 | 0 | 0 |
| GRB7 events in ERBB2 signaling | R-HSA-1306955 | 1.711164e-01 | 0.767 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 1.576939e-01 | 0.802 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 1.576939e-01 | 0.802 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 1.576939e-01 | 0.802 | 0 | 0 |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | R-HSA-9828211 | 1.576939e-01 | 0.802 | 1 | 1 |
| MET receptor recycling | R-HSA-8875656 | 1.576939e-01 | 0.802 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 1.397733e-01 | 0.855 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 1.397733e-01 | 0.855 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 1.397733e-01 | 0.855 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 1.397733e-01 | 0.855 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 1.397733e-01 | 0.855 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 1.626278e-01 | 0.789 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 1.626278e-01 | 0.789 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 1.626278e-01 | 0.789 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 1.409966e-01 | 0.851 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 1.602053e-01 | 0.795 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 1.339667e-01 | 0.873 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 1.339667e-01 | 0.873 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 1.485909e-01 | 0.828 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 1.724003e-01 | 0.763 | 0 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 1.724003e-01 | 0.763 | 0 | 0 |
| DAP12 signaling | R-HSA-2424491 | 1.639288e-01 | 0.785 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 1.476706e-01 | 0.831 | 0 | 0 |
| Protein folding | R-HSA-391251 | 1.392262e-01 | 0.856 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 1.632456e-01 | 0.787 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 1.581613e-01 | 0.801 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 1.722050e-01 | 0.764 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 1.520497e-01 | 0.818 | 0 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 1.611667e-01 | 0.793 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 1.418154e-01 | 0.848 | 1 | 0 |
| UCH proteinases | R-HSA-5689603 | 1.668354e-01 | 0.778 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 1.409966e-01 | 0.851 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 1.697607e-01 | 0.770 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 1.470461e-01 | 0.833 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 1.532230e-01 | 0.815 | 0 | 0 |
| Apoptotic factor-mediated response | R-HSA-111471 | 1.602053e-01 | 0.795 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 1.639288e-01 | 0.785 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 1.464635e-01 | 0.834 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 1.418154e-01 | 0.848 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 1.602053e-01 | 0.795 | 1 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 1.698847e-01 | 0.770 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 1.347195e-01 | 0.871 | 0 | 0 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | R-HSA-9615017 | 1.601494e-01 | 0.795 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 1.549660e-01 | 0.810 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 1.323172e-01 | 0.878 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 1.349930e-01 | 0.870 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 1.554118e-01 | 0.809 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 1.554118e-01 | 0.809 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 1.464635e-01 | 0.834 | 1 | 1 |
| Hemostasis | R-HSA-109582 | 1.589948e-01 | 0.799 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 1.697607e-01 | 0.770 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 1.394658e-01 | 0.856 | 0 | 0 |
| NADE modulates death signalling | R-HSA-205025 | 1.711164e-01 | 0.767 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 1.397733e-01 | 0.855 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 1.418154e-01 | 0.848 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 1.446073e-01 | 0.840 | 0 | 0 |
| Tie2 Signaling | R-HSA-210993 | 1.602053e-01 | 0.795 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 1.632456e-01 | 0.787 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 1.735150e-01 | 0.761 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 1.735150e-01 | 0.761 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 1.735150e-01 | 0.761 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 1.745375e-01 | 0.758 | 0 | 0 |
| Regulation of PAK-2p34 activity by PS-GAP/RHG10 | R-HSA-211728 | 2.195772e-01 | 0.658 | 0 | 0 |
| Hereditary fructose intolerance | R-HSA-5657560 | 2.195772e-01 | 0.658 | 0 | 0 |
| Impaired BRCA2 translocation to the nucleus | R-HSA-9709275 | 2.195772e-01 | 0.658 | 0 | 0 |
| Defective F8 binding to von Willebrand factor | R-HSA-9672393 | 2.195772e-01 | 0.658 | 0 | 0 |
| Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) | R-HSA-5619110 | 2.195772e-01 | 0.658 | 0 | 0 |
| Defective Mismatch Repair Associated With MLH1 | R-HSA-5545483 | 2.195772e-01 | 0.658 | 0 | 0 |
| Defective Mismatch Repair Associated With PMS2 | R-HSA-5632987 | 2.195772e-01 | 0.658 | 0 | 0 |
| Impaired BRCA2 binding to SEM1 (DSS1) | R-HSA-9763198 | 2.195772e-01 | 0.658 | 0 | 0 |
| Defective DNA double strand break response due to BARD1 loss of function | R-HSA-9699150 | 2.195772e-01 | 0.658 | 0 | 0 |
| Defective DNA double strand break response due to BRCA1 loss of function | R-HSA-9663199 | 2.195772e-01 | 0.658 | 0 | 0 |
| t(4;14) translocations of FGFR3 | R-HSA-2033515 | 3.105705e-01 | 0.508 | 0 | 0 |
| Signaling by FGFR3 fusions in cancer | R-HSA-8853334 | 3.105705e-01 | 0.508 | 0 | 0 |
| Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) | R-HSA-5619039 | 3.105705e-01 | 0.508 | 0 | 0 |
| Defective VWF binding to collagen type I | R-HSA-9845622 | 3.105705e-01 | 0.508 | 0 | 0 |
| IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | R-HSA-5603027 | 3.105705e-01 | 0.508 | 0 | 0 |
| Defective SLC6A2 causes orthostatic intolerance (OI) | R-HSA-5619109 | 3.105705e-01 | 0.508 | 0 | 0 |
| Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome | R-HSA-5678420 | 3.105705e-01 | 0.508 | 0 | 0 |
| XAV939 stabilizes AXIN | R-HSA-5545619 | 3.105705e-01 | 0.508 | 0 | 0 |
| Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) | R-HSA-5619054 | 3.105705e-01 | 0.508 | 0 | 0 |
| Defective PGM1 causes PGM1-CDG | R-HSA-5609974 | 3.105705e-01 | 0.508 | 0 | 0 |
| IKBKB deficiency causes SCID | R-HSA-5602636 | 3.105705e-01 | 0.508 | 0 | 0 |
| NrCAM interactions | R-HSA-447038 | 2.156990e-01 | 0.666 | 0 | 0 |
| Activation of AKT2 | R-HSA-165158 | 2.156990e-01 | 0.666 | 0 | 0 |
| NFE2L2 regulating inflammation associated genes | R-HSA-9818026 | 2.156990e-01 | 0.666 | 0 | 0 |
| Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 2.156990e-01 | 0.666 | 0 | 0 |
| Defective binding of VWF variant to GPIb:IX:V | R-HSA-9846298 | 2.156990e-01 | 0.666 | 0 | 0 |
| Enhanced binding of GP1BA variant to VWF multimer:collagen | R-HSA-9845620 | 2.156990e-01 | 0.666 | 0 | 0 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | 2.156990e-01 | 0.666 | 0 | 0 |
| Estrogen-stimulated signaling through PRKCZ | R-HSA-9634635 | 1.879554e-01 | 0.726 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 1.879554e-01 | 0.726 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 1.879554e-01 | 0.726 | 0 | 0 |
| Inactivation of CDC42 and RAC1 | R-HSA-428543 | 1.879554e-01 | 0.726 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 1.879554e-01 | 0.726 | 0 | 0 |
| MAPK1 (ERK2) activation | R-HSA-112411 | 1.879554e-01 | 0.726 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 1.879554e-01 | 0.726 | 0 | 0 |
| Defects of platelet adhesion to exposed collagen | R-HSA-9823587 | 2.611563e-01 | 0.583 | 0 | 0 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | 2.611563e-01 | 0.583 | 0 | 0 |
| Signalling to ERK5 | R-HSA-198765 | 3.909591e-01 | 0.408 | 0 | 0 |
| TGFBR1 LBD Mutants in Cancer | R-HSA-3656535 | 3.909591e-01 | 0.408 | 0 | 0 |
| Defective VWF cleavage by ADAMTS13 variant | R-HSA-9845621 | 3.909591e-01 | 0.408 | 0 | 0 |
| Enhanced cleavage of VWF variant by ADAMTS13 | R-HSA-9845619 | 3.909591e-01 | 0.408 | 0 | 0 |
| Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | R-HSA-5619089 | 3.909591e-01 | 0.408 | 0 | 0 |
| TWIK related potassium channel (TREK) | R-HSA-1299503 | 3.909591e-01 | 0.408 | 0 | 0 |
| TGFBR2 Kinase Domain Mutants in Cancer | R-HSA-3645790 | 3.909591e-01 | 0.408 | 0 | 0 |
| Defective F8 cleavage by thrombin | R-HSA-9672391 | 3.909591e-01 | 0.408 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 1.867190e-01 | 0.729 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 1.867190e-01 | 0.729 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 1.867190e-01 | 0.729 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 1.867190e-01 | 0.729 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 1.867190e-01 | 0.729 | 0 | 0 |
| RUNX3 regulates YAP1-mediated transcription | R-HSA-8951671 | 3.066789e-01 | 0.513 | 0 | 0 |
| E2F-enabled inhibition of pre-replication complex formation | R-HSA-113507 | 3.066789e-01 | 0.513 | 0 | 0 |
| RAS signaling downstream of NF1 loss-of-function variants | R-HSA-6802953 | 3.066789e-01 | 0.513 | 0 | 0 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | 2.521000e-01 | 0.598 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 2.521000e-01 | 0.598 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 2.521000e-01 | 0.598 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 2.521000e-01 | 0.598 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 2.118655e-01 | 0.674 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 2.118655e-01 | 0.674 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 2.118655e-01 | 0.674 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 1.804011e-01 | 0.744 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 2.014814e-01 | 0.696 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 2.378842e-01 | 0.624 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 2.852824e-01 | 0.545 | 0 | 0 |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | R-HSA-9824878 | 2.852824e-01 | 0.545 | 1 | 1 |
| ERKs are inactivated | R-HSA-202670 | 2.852824e-01 | 0.545 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 2.852824e-01 | 0.545 | 0 | 0 |
| Binding of TCF/LEF:CTNNB1 to target gene promoters | R-HSA-4411364 | 3.516340e-01 | 0.454 | 0 | 0 |
| IFNG signaling activates MAPKs | R-HSA-9732724 | 3.516340e-01 | 0.454 | 0 | 0 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 3.516340e-01 | 0.454 | 0 | 0 |
| Disinhibition of SNARE formation | R-HSA-114516 | 3.516340e-01 | 0.454 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 3.516340e-01 | 0.454 | 0 | 0 |
| Regulation of MITF-M dependent genes involved in metabolism | R-HSA-9854907 | 4.619784e-01 | 0.335 | 0 | 0 |
| Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | R-HSA-9673766 | 4.619784e-01 | 0.335 | 0 | 0 |
| Loss of Function of KMT2D in Kabuki Syndrome | R-HSA-9944971 | 4.619784e-01 | 0.335 | 0 | 0 |
| Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | R-HSA-9944997 | 4.619784e-01 | 0.335 | 0 | 0 |
| MET activates PTPN11 | R-HSA-8865999 | 4.619784e-01 | 0.335 | 0 | 0 |
| Invadopodia formation | R-HSA-8941237 | 4.619784e-01 | 0.335 | 0 | 0 |
| Defective SLC7A7 causes lysinuric protein intolerance (LPI) | R-HSA-5660862 | 4.619784e-01 | 0.335 | 0 | 0 |
| IRAK4 deficiency (TLR5) | R-HSA-5603037 | 4.619784e-01 | 0.335 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 2.233386e-01 | 0.651 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 2.645933e-01 | 0.577 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 2.645933e-01 | 0.577 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 1.799386e-01 | 0.745 | 0 | 0 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | R-HSA-975144 | 3.187831e-01 | 0.497 | 0 | 0 |
| IRAK1 recruits IKK complex | R-HSA-937039 | 3.187831e-01 | 0.497 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 3.187831e-01 | 0.497 | 0 | 0 |
| FRS-mediated FGFR3 signaling | R-HSA-5654706 | 2.458620e-01 | 0.609 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 2.458620e-01 | 0.609 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 1.846006e-01 | 0.734 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 2.290071e-01 | 0.640 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 2.290071e-01 | 0.640 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 3.955355e-01 | 0.403 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 2.689400e-01 | 0.570 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 2.490710e-01 | 0.604 | 1 | 1 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 3.523236e-01 | 0.453 | 0 | 0 |
| FGFR3 mutant receptor activation | R-HSA-2033514 | 3.523236e-01 | 0.453 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | R-HSA-9029558 | 3.523236e-01 | 0.453 | 0 | 0 |
| Signaling by activated point mutants of FGFR3 | R-HSA-1839130 | 3.523236e-01 | 0.453 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 2.315252e-01 | 0.635 | 0 | 0 |
| Interleukin receptor SHC signaling | R-HSA-912526 | 2.924612e-01 | 0.534 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 2.696065e-01 | 0.569 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 2.696065e-01 | 0.569 | 0 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 2.316281e-01 | 0.635 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 2.905364e-01 | 0.537 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 3.471293e-01 | 0.460 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 3.471293e-01 | 0.460 | 0 | 0 |
| NFE2L2 regulating MDR associated enzymes | R-HSA-9818032 | 4.380180e-01 | 0.359 | 0 | 0 |
| Interleukin-21 signaling | R-HSA-9020958 | 4.380180e-01 | 0.359 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 4.380180e-01 | 0.359 | 0 | 0 |
| HCN channels | R-HSA-1296061 | 5.247199e-01 | 0.280 | 0 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 5.247199e-01 | 0.280 | 0 | 0 |
| ATP sensitive Potassium channels | R-HSA-1296025 | 5.247199e-01 | 0.280 | 0 | 0 |
| Drug-mediated inhibition of CDK4/CDK6 activity | R-HSA-9754119 | 5.247199e-01 | 0.280 | 0 | 0 |
| Signaling by MAP2K mutants | R-HSA-9652169 | 5.247199e-01 | 0.280 | 0 | 0 |
| Carboxyterminal post-translational modifications of tubulin | R-HSA-8955332 | 2.471698e-01 | 0.607 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 2.630516e-01 | 0.580 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 3.749091e-01 | 0.426 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 2.792386e-01 | 0.554 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 4.185700e-01 | 0.378 | 0 | 0 |
| SHC-mediated cascade:FGFR3 | R-HSA-5654704 | 4.025818e-01 | 0.395 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 4.025818e-01 | 0.395 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 4.788157e-01 | 0.320 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 4.788157e-01 | 0.320 | 0 | 0 |
| Folding of actin by CCT/TriC | R-HSA-390450 | 4.788157e-01 | 0.320 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 3.888398e-01 | 0.410 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 3.766754e-01 | 0.424 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 3.656911e-01 | 0.437 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 3.463216e-01 | 0.461 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 3.463216e-01 | 0.461 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 3.376356e-01 | 0.472 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 3.984488e-01 | 0.400 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 3.984488e-01 | 0.400 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 3.134263e-01 | 0.504 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 2.985434e-01 | 0.525 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 3.807569e-01 | 0.419 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 4.055434e-01 | 0.392 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 4.055434e-01 | 0.392 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 4.055434e-01 | 0.392 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 4.370296e-01 | 0.359 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 4.571113e-01 | 0.340 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 4.824203e-01 | 0.317 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 2.652874e-01 | 0.576 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 4.452834e-01 | 0.351 | 0 | 0 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 5.130738e-01 | 0.290 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 3.598050e-01 | 0.444 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 4.845118e-01 | 0.315 | 0 | 0 |
| Thromboxane signalling through TP receptor | R-HSA-428930 | 5.098535e-01 | 0.293 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 4.302630e-01 | 0.366 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 4.845316e-01 | 0.315 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 4.845316e-01 | 0.315 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 4.845316e-01 | 0.315 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 5.074269e-01 | 0.295 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 4.844445e-01 | 0.315 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 4.840964e-01 | 0.315 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 4.838735e-01 | 0.315 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 4.785581e-01 | 0.320 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 4.361567e-01 | 0.360 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 2.094912e-01 | 0.679 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 3.909187e-01 | 0.408 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 3.909187e-01 | 0.408 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 2.658332e-01 | 0.575 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 4.689333e-01 | 0.329 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 4.429374e-01 | 0.354 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 4.370296e-01 | 0.359 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 2.421347e-01 | 0.616 | 0 | 0 |
| FOXO-mediated transcription of cell cycle genes | R-HSA-9617828 | 2.458620e-01 | 0.609 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 3.193813e-01 | 0.496 | 0 | 0 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | R-HSA-9670439 | 4.571113e-01 | 0.340 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 4.500044e-01 | 0.347 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 1.886767e-01 | 0.724 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 2.885083e-01 | 0.540 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 1.894045e-01 | 0.723 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 4.370296e-01 | 0.359 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 4.608196e-01 | 0.336 | 0 | 0 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 5.229500e-01 | 0.282 | 0 | 0 |
| Signaling by BMP | R-HSA-201451 | 3.888398e-01 | 0.410 | 0 | 0 |
| Platelet Adhesion to exposed collagen | R-HSA-75892 | 3.523236e-01 | 0.453 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 3.065724e-01 | 0.513 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 3.186967e-01 | 0.497 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 1.775891e-01 | 0.751 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 4.845316e-01 | 0.315 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 1.886767e-01 | 0.724 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 3.856061e-01 | 0.414 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 5.012457e-01 | 0.300 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 3.332717e-01 | 0.477 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 5.001503e-01 | 0.301 | 0 | 0 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 4.632688e-01 | 0.334 | 1 | 1 |
| TCR signaling | R-HSA-202403 | 4.444682e-01 | 0.352 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 2.748280e-01 | 0.561 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 3.984488e-01 | 0.400 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 3.148940e-01 | 0.502 | 0 | 0 |
| Regulation of the apoptosome activity | R-HSA-9627069 | 2.195450e-01 | 0.658 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 2.118655e-01 | 0.674 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 3.066180e-01 | 0.513 | 0 | 0 |
| PI3K Cascade | R-HSA-109704 | 2.956952e-01 | 0.529 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 4.220835e-01 | 0.375 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 3.260670e-01 | 0.487 | 1 | 1 |
| G1 Phase | R-HSA-69236 | 3.191600e-01 | 0.496 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 3.191600e-01 | 0.496 | 0 | 0 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 2.645933e-01 | 0.577 | 1 | 1 |
| Meiosis | R-HSA-1500620 | 2.692921e-01 | 0.570 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 2.195450e-01 | 0.658 | 0 | 0 |
| Formation of apoptosome | R-HSA-111458 | 2.195450e-01 | 0.658 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 2.195450e-01 | 0.658 | 0 | 0 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 4.508761e-01 | 0.346 | 0 | 0 |
| Induction of Cell-Cell Fusion | R-HSA-9733458 | 4.508761e-01 | 0.346 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 3.656911e-01 | 0.437 | 0 | 0 |
| Regulation of IFNA/IFNB signaling | R-HSA-912694 | 4.571113e-01 | 0.340 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 5.074269e-01 | 0.295 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 2.051016e-01 | 0.688 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 2.934249e-01 | 0.533 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 2.497336e-01 | 0.603 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 3.925273e-01 | 0.406 | 0 | 0 |
| Regulation of FOXO transcriptional activity by acetylation | R-HSA-9617629 | 3.187831e-01 | 0.497 | 0 | 0 |
| CD163 mediating an anti-inflammatory response | R-HSA-9662834 | 5.177439e-01 | 0.286 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 4.393637e-01 | 0.357 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 1.928366e-01 | 0.715 | 0 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 3.117835e-01 | 0.506 | 1 | 1 |
| S Phase | R-HSA-69242 | 2.517089e-01 | 0.599 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 3.615781e-01 | 0.442 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 2.020399e-01 | 0.695 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 5.130510e-01 | 0.290 | 0 | 0 |
| Caspase activation via Dependence Receptors in the absence of ligand | R-HSA-418889 | 1.879554e-01 | 0.726 | 0 | 0 |
| MASTL Facilitates Mitotic Progression | R-HSA-2465910 | 1.879554e-01 | 0.726 | 0 | 0 |
| E2F mediated regulation of DNA replication | R-HSA-113510 | 1.804011e-01 | 0.744 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 2.852824e-01 | 0.545 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 2.645933e-01 | 0.577 | 0 | 0 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | 3.187831e-01 | 0.497 | 0 | 0 |
| Nef mediated downregulation of MHC class I complex cell surface expression | R-HSA-164940 | 3.955355e-01 | 0.403 | 0 | 0 |
| Translesion Synthesis by POLH | R-HSA-110320 | 3.471293e-01 | 0.460 | 0 | 0 |
| cGMP effects | R-HSA-418457 | 3.856576e-01 | 0.414 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 3.117835e-01 | 0.506 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 2.630516e-01 | 0.580 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 4.189824e-01 | 0.378 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 2.485825e-01 | 0.605 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 2.852824e-01 | 0.545 | 1 | 1 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 2.595701e-01 | 0.586 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 3.163161e-01 | 0.500 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 4.508761e-01 | 0.346 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 2.183624e-01 | 0.661 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 1.905982e-01 | 0.720 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 2.689400e-01 | 0.570 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 3.193813e-01 | 0.496 | 0 | 0 |
| ERK/MAPK targets | R-HSA-198753 | 4.025818e-01 | 0.395 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 3.429574e-01 | 0.465 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 4.672017e-01 | 0.330 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 4.672017e-01 | 0.330 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 4.672017e-01 | 0.330 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 4.672017e-01 | 0.330 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 4.844445e-01 | 0.315 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 2.934249e-01 | 0.533 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 2.848193e-01 | 0.545 | 0 | 0 |
| Interleukin-6 signaling | R-HSA-1059683 | 3.523236e-01 | 0.453 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 1.981031e-01 | 0.703 | 0 | 0 |
| Response of EIF2AK1 (HRI) to heme deficiency | R-HSA-9648895 | 4.837521e-01 | 0.315 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 1.965746e-01 | 0.706 | 0 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 2.609585e-01 | 0.583 | 1 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 2.609585e-01 | 0.583 | 1 | 0 |
| PTEN Regulation | R-HSA-6807070 | 3.006463e-01 | 0.522 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 3.776854e-01 | 0.423 | 0 | 0 |
| Pyrophosphate hydrolysis | R-HSA-71737 | 2.156990e-01 | 0.666 | 0 | 0 |
| Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 2.611563e-01 | 0.583 | 0 | 0 |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | R-HSA-113501 | 2.852824e-01 | 0.545 | 0 | 0 |
| Microbial modulation of RIPK1-mediated regulated necrosis | R-HSA-9686347 | 3.516340e-01 | 0.454 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 2.094912e-01 | 0.679 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 2.137875e-01 | 0.670 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 2.315252e-01 | 0.635 | 0 | 0 |
| Regulation of CDH1 mRNA translation by microRNAs | R-HSA-9764562 | 3.856576e-01 | 0.414 | 0 | 0 |
| mRNA Editing | R-HSA-75072 | 4.380180e-01 | 0.359 | 0 | 0 |
| WNT5:FZD7-mediated leishmania damping | R-HSA-9673324 | 4.508761e-01 | 0.346 | 0 | 0 |
| Killing mechanisms | R-HSA-9664420 | 4.508761e-01 | 0.346 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 4.837521e-01 | 0.315 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 4.566117e-01 | 0.340 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 4.966224e-01 | 0.304 | 0 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 3.776854e-01 | 0.423 | 0 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 3.776854e-01 | 0.423 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 3.011937e-01 | 0.521 | 0 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 5.217504e-01 | 0.283 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 2.906388e-01 | 0.537 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 2.885083e-01 | 0.540 | 1 | 0 |
| HIV Infection | R-HSA-162906 | 4.966532e-01 | 0.304 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 1.873736e-01 | 0.727 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 2.696065e-01 | 0.569 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 1.907727e-01 | 0.719 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 2.137875e-01 | 0.670 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 3.193813e-01 | 0.496 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 4.541709e-01 | 0.343 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 2.683565e-01 | 0.571 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 2.378842e-01 | 0.624 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 2.995199e-01 | 0.524 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 4.219915e-01 | 0.375 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 2.129919e-01 | 0.672 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 2.659344e-01 | 0.575 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 3.187831e-01 | 0.497 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 2.696065e-01 | 0.569 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 3.852014e-01 | 0.414 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 2.094912e-01 | 0.679 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 4.096099e-01 | 0.388 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 2.583207e-01 | 0.588 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 3.011937e-01 | 0.521 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 5.202385e-01 | 0.284 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 4.922040e-01 | 0.308 | 1 | 0 |
| Formation of intermediate mesoderm | R-HSA-9761174 | 2.195450e-01 | 0.658 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 1.867190e-01 | 0.729 | 0 | 0 |
| SARS-CoV-1-mediated effects on programmed cell death | R-HSA-9692913 | 5.247199e-01 | 0.280 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 4.185700e-01 | 0.378 | 1 | 1 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 4.571113e-01 | 0.340 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 5.177439e-01 | 0.286 | 0 | 0 |
| Synthesis of pyrophosphates in the cytosol | R-HSA-1855167 | 4.837521e-01 | 0.315 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 5.130738e-01 | 0.290 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 2.660241e-01 | 0.575 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 3.749091e-01 | 0.426 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 3.749091e-01 | 0.426 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 4.843074e-01 | 0.315 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 2.658332e-01 | 0.575 | 1 | 0 |
| TRP channels | R-HSA-3295583 | 3.646053e-01 | 0.438 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 2.770499e-01 | 0.557 | 0 | 0 |
| Synthesis of PIPs at the late endosome membrane | R-HSA-1660517 | 5.130738e-01 | 0.290 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 3.847908e-01 | 0.415 | 1 | 0 |
| Developmental Biology | R-HSA-1266738 | 4.541160e-01 | 0.343 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 3.191600e-01 | 0.496 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 2.905364e-01 | 0.537 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 5.130738e-01 | 0.290 | 0 | 0 |
| DAP12 interactions | R-HSA-2172127 | 4.649911e-01 | 0.333 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 4.185700e-01 | 0.378 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 3.650900e-01 | 0.438 | 1 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 3.960417e-01 | 0.402 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 2.818648e-01 | 0.550 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 4.672017e-01 | 0.330 | 0 | 0 |
| SDK interactions | R-HSA-373756 | 2.195772e-01 | 0.658 | 0 | 0 |
| Manipulation of host energy metabolism | R-HSA-9636667 | 3.105705e-01 | 0.508 | 0 | 0 |
| Noncanonical activation of NOTCH3 | R-HSA-9017802 | 2.611563e-01 | 0.583 | 0 | 0 |
| Defective ABCC8 can cause hypo- and hyper-glycemias | R-HSA-5683177 | 3.909591e-01 | 0.408 | 0 | 0 |
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | R-HSA-446343 | 3.909591e-01 | 0.408 | 0 | 0 |
| Neurophilin interactions with VEGF and VEGFR | R-HSA-194306 | 3.909591e-01 | 0.408 | 0 | 0 |
| Loss of Function of TGFBR2 in Cancer | R-HSA-3642278 | 3.909591e-01 | 0.408 | 0 | 0 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | 2.195450e-01 | 0.658 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 2.521000e-01 | 0.598 | 0 | 0 |
| Netrin mediated repulsion signals | R-HSA-418886 | 3.516340e-01 | 0.454 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 2.645933e-01 | 0.577 | 0 | 0 |
| MET activates RAS signaling | R-HSA-8851805 | 3.187831e-01 | 0.497 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 2.458620e-01 | 0.609 | 0 | 0 |
| Activation of RAS in B cells | R-HSA-1169092 | 3.955355e-01 | 0.403 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 1.776346e-01 | 0.750 | 0 | 0 |
| Unwinding of DNA | R-HSA-176974 | 4.380180e-01 | 0.359 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 5.247199e-01 | 0.280 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 5.247199e-01 | 0.280 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 5.177439e-01 | 0.286 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 2.230439e-01 | 0.652 | 0 | 0 |
| Modulation of host responses by IFN-stimulated genes | R-HSA-9909505 | 5.130738e-01 | 0.290 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 5.098535e-01 | 0.293 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 2.905364e-01 | 0.537 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 3.471293e-01 | 0.460 | 1 | 0 |
| Pexophagy | R-HSA-9664873 | 2.195450e-01 | 0.658 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 1.985635e-01 | 0.702 | 0 | 0 |
| Signaling by FLT3 ITD and TKD mutants | R-HSA-9703648 | 5.098535e-01 | 0.293 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 3.471293e-01 | 0.460 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 4.370296e-01 | 0.359 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 2.521000e-01 | 0.598 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 4.380180e-01 | 0.359 | 0 | 0 |
| Signaling by PDGFRA extracellular domain mutants | R-HSA-9673770 | 4.185700e-01 | 0.378 | 0 | 0 |
| Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | R-HSA-9673767 | 4.185700e-01 | 0.378 | 0 | 0 |
| Receptor Mediated Mitophagy | R-HSA-8934903 | 4.788157e-01 | 0.320 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 4.530381e-01 | 0.344 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 4.337174e-01 | 0.363 | 1 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 2.458620e-01 | 0.609 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 4.508761e-01 | 0.346 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 5.098535e-01 | 0.293 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 5.098535e-01 | 0.293 | 0 | 0 |
| Epithelial-Mesenchymal Transition (EMT) during gastrulation | R-HSA-9758919 | 2.611563e-01 | 0.583 | 0 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 1.867190e-01 | 0.729 | 0 | 0 |
| RUNX3 Regulates Immune Response and Cell Migration | R-HSA-8949275 | 3.516340e-01 | 0.454 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 2.233386e-01 | 0.651 | 0 | 0 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | 4.380180e-01 | 0.359 | 0 | 0 |
| Activation of NOXA and translocation to mitochondria | R-HSA-111448 | 5.247199e-01 | 0.280 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 2.000809e-01 | 0.699 | 0 | 0 |
| RAB geranylgeranylation | R-HSA-8873719 | 3.376356e-01 | 0.472 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 2.490710e-01 | 0.604 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 3.373208e-01 | 0.472 | 0 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 4.461660e-01 | 0.351 | 0 | 0 |
| Signaling by KIT in disease | R-HSA-9669938 | 4.571113e-01 | 0.340 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 3.862805e-01 | 0.413 | 0 | 0 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 1.799386e-01 | 0.745 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 3.646053e-01 | 0.438 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 4.327440e-01 | 0.364 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 2.699308e-01 | 0.569 | 1 | 1 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 2.290071e-01 | 0.640 | 0 | 0 |
| Synthesis of IP2, IP, and Ins in the cytosol | R-HSA-1855183 | 3.646053e-01 | 0.438 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 3.699791e-01 | 0.432 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 3.935538e-01 | 0.405 | 1 | 0 |
| Other interleukin signaling | R-HSA-449836 | 3.471293e-01 | 0.460 | 0 | 0 |
| TRAIL signaling | R-HSA-75158 | 2.611563e-01 | 0.583 | 0 | 0 |
| Intracellular oxygen transport | R-HSA-8981607 | 4.619784e-01 | 0.335 | 0 | 0 |
| Diseases of Mismatch Repair (MMR) | R-HSA-5423599 | 4.619784e-01 | 0.335 | 0 | 0 |
| CASP5-mediated substrate cleavage | R-HSA-9960525 | 4.619784e-01 | 0.335 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 2.645933e-01 | 0.577 | 0 | 0 |
| TGFBR3 PTM regulation | R-HSA-9839383 | 3.955355e-01 | 0.403 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 2.696065e-01 | 0.569 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 4.380180e-01 | 0.359 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 3.549264e-01 | 0.450 | 0 | 0 |
| Receptor-type tyrosine-protein phosphatases | R-HSA-388844 | 4.508761e-01 | 0.346 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 2.770499e-01 | 0.557 | 0 | 0 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | 2.458620e-01 | 0.609 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 2.211469e-01 | 0.655 | 0 | 0 |
| Activated NTRK2 signals through FRS2 and FRS3 | R-HSA-9028731 | 3.187831e-01 | 0.497 | 0 | 0 |
| TP53 Regulates Transcription of Death Receptors and Ligands | R-HSA-6803211 | 3.856576e-01 | 0.414 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 4.380180e-01 | 0.359 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 3.549264e-01 | 0.450 | 0 | 0 |
| Signaling by FGFR4 in disease | R-HSA-5655291 | 3.856576e-01 | 0.414 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 3.292731e-01 | 0.482 | 1 | 1 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 4.571113e-01 | 0.340 | 0 | 0 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | R-HSA-164938 | 5.130738e-01 | 0.290 | 0 | 0 |
| Activation, myristolyation of BID and translocation to mitochondria | R-HSA-75108 | 3.909591e-01 | 0.408 | 0 | 0 |
| CASP4-mediated substrate cleavage | R-HSA-9960519 | 4.619784e-01 | 0.335 | 0 | 0 |
| Assembly and release of respiratory syncytial virus (RSV) virions | R-HSA-9820962 | 4.788157e-01 | 0.320 | 0 | 0 |
| MAPK3 (ERK1) activation | R-HSA-110056 | 4.788157e-01 | 0.320 | 0 | 0 |
| Activated NTRK3 signals through RAS | R-HSA-9034864 | 5.177439e-01 | 0.286 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 4.837521e-01 | 0.315 | 0 | 0 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 2.290071e-01 | 0.640 | 0 | 0 |
| Other semaphorin interactions | R-HSA-416700 | 4.185700e-01 | 0.378 | 0 | 0 |
| Activation of SMO | R-HSA-5635838 | 4.508761e-01 | 0.346 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 4.875701e-01 | 0.312 | 1 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 2.195450e-01 | 0.658 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 2.918157e-01 | 0.535 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 2.156990e-01 | 0.666 | 0 | 0 |
| Uptake and function of diphtheria toxin | R-HSA-5336415 | 3.516340e-01 | 0.454 | 0 | 0 |
| Respiratory syncytial virus genome replication | R-HSA-9834752 | 4.380180e-01 | 0.359 | 0 | 0 |
| Interleukin-1 processing | R-HSA-448706 | 4.380180e-01 | 0.359 | 0 | 0 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | R-HSA-9013700 | 4.380180e-01 | 0.359 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 4.341810e-01 | 0.362 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 3.261418e-01 | 0.487 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 4.837521e-01 | 0.315 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 5.088596e-01 | 0.293 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 5.127628e-01 | 0.290 | 0 | 0 |
| Butyrophilin (BTN) family interactions | R-HSA-8851680 | 4.380180e-01 | 0.359 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 5.261404e-01 | 0.279 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 5.261404e-01 | 0.279 | 0 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 5.277136e-01 | 0.278 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 5.301191e-01 | 0.276 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 5.301191e-01 | 0.276 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 5.345477e-01 | 0.272 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 5.353382e-01 | 0.271 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 5.379003e-01 | 0.269 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 5.379003e-01 | 0.269 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 5.408715e-01 | 0.267 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 5.417550e-01 | 0.266 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 5.427327e-01 | 0.265 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 5.427327e-01 | 0.265 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 5.427327e-01 | 0.265 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 5.427327e-01 | 0.265 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 5.523318e-01 | 0.258 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 5.546840e-01 | 0.256 | 0 | 0 |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | 5.546840e-01 | 0.256 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | R-HSA-9623433 | 5.546840e-01 | 0.256 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 5.546840e-01 | 0.256 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 5.546840e-01 | 0.256 | 0 | 0 |
| Activated NTRK2 signals through RAS | R-HSA-9026519 | 5.546840e-01 | 0.256 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 5.577980e-01 | 0.254 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 5.601405e-01 | 0.252 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 5.601405e-01 | 0.252 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 5.601405e-01 | 0.252 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 5.602467e-01 | 0.252 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 5.602467e-01 | 0.252 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 5.627868e-01 | 0.250 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 5.627868e-01 | 0.250 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 5.663361e-01 | 0.247 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 5.663361e-01 | 0.247 | 0 | 0 |
| Germ layer formation at gastrulation | R-HSA-9754189 | 5.713158e-01 | 0.243 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 5.713158e-01 | 0.243 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 5.740191e-01 | 0.241 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 5.740191e-01 | 0.241 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 5.783962e-01 | 0.238 | 0 | 0 |
| Regulation of MITF-M dependent genes involved in invasion | R-HSA-9854909 | 5.801480e-01 | 0.236 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in interleukin signaling | R-HSA-8939247 | 5.801480e-01 | 0.236 | 0 | 0 |
| NFE2L2 regulating TCA cycle genes | R-HSA-9818025 | 5.801480e-01 | 0.236 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in BCR signaling | R-HSA-8939245 | 5.801480e-01 | 0.236 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 5.801480e-01 | 0.236 | 0 | 0 |
| FLT3 signaling by CBL mutants | R-HSA-9706377 | 5.801480e-01 | 0.236 | 0 | 0 |
| Defective F9 activation | R-HSA-9673221 | 5.801480e-01 | 0.236 | 0 | 0 |
| IRF3 mediated activation of type 1 IFN | R-HSA-1606341 | 5.801480e-01 | 0.236 | 1 | 1 |
| PTK6 Down-Regulation | R-HSA-8849472 | 5.801480e-01 | 0.236 | 0 | 0 |
| Post-transcriptional silencing by small RNAs | R-HSA-426496 | 5.801480e-01 | 0.236 | 0 | 0 |
| Trafficking of myristoylated proteins to the cilium | R-HSA-5624138 | 5.801480e-01 | 0.236 | 0 | 0 |
| Reelin signalling pathway | R-HSA-8866376 | 5.801480e-01 | 0.236 | 0 | 0 |
| Suppression of autophagy | R-HSA-9636569 | 5.801480e-01 | 0.236 | 0 | 0 |
| Co-inhibition by BTLA | R-HSA-9927353 | 5.801480e-01 | 0.236 | 0 | 0 |
| Zinc efflux and compartmentalization by the SLC30 family | R-HSA-435368 | 5.801480e-01 | 0.236 | 0 | 0 |
| Nectin/Necl trans heterodimerization | R-HSA-420597 | 5.801480e-01 | 0.236 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 5.830944e-01 | 0.234 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 5.842055e-01 | 0.233 | 0 | 0 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 5.842055e-01 | 0.233 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 5.842055e-01 | 0.233 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 5.842055e-01 | 0.233 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 5.842055e-01 | 0.233 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 5.845767e-01 | 0.233 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 5.858042e-01 | 0.232 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 5.890784e-01 | 0.230 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 5.895702e-01 | 0.229 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 5.895702e-01 | 0.229 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 5.895702e-01 | 0.229 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 5.895702e-01 | 0.229 | 0 | 0 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | 5.895702e-01 | 0.229 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 5.895702e-01 | 0.229 | 0 | 0 |
| Signaling by LTK | R-HSA-9842663 | 5.895702e-01 | 0.229 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | R-HSA-2691232 | 5.895702e-01 | 0.229 | 0 | 0 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | R-HSA-2691230 | 5.895702e-01 | 0.229 | 0 | 0 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 5.895702e-01 | 0.229 | 0 | 0 |
| SHC-related events triggered by IGF1R | R-HSA-2428933 | 5.895702e-01 | 0.229 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 5.928808e-01 | 0.227 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 5.951417e-01 | 0.225 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 5.968377e-01 | 0.224 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 5.987257e-01 | 0.223 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 5.987622e-01 | 0.223 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 6.055192e-01 | 0.218 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 6.074887e-01 | 0.216 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 6.074887e-01 | 0.216 | 0 | 0 |
| Insulin receptor recycling | R-HSA-77387 | 6.074887e-01 | 0.216 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 6.074887e-01 | 0.216 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 6.121014e-01 | 0.213 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 6.122777e-01 | 0.213 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 6.128888e-01 | 0.213 | 1 | 0 |
| MAP kinase activation | R-HSA-450294 | 6.216179e-01 | 0.206 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 6.219794e-01 | 0.206 | 0 | 0 |
| RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | R-HSA-8877330 | 6.223791e-01 | 0.206 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 6.223791e-01 | 0.206 | 0 | 0 |
| Golgi Cisternae Pericentriolar Stack Reorganization | R-HSA-162658 | 6.223791e-01 | 0.206 | 0 | 0 |
| Membrane binding and targetting of GAG proteins | R-HSA-174490 | 6.223791e-01 | 0.206 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 6.223791e-01 | 0.206 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 6.223791e-01 | 0.206 | 0 | 0 |
| Reversible hydration of carbon dioxide | R-HSA-1475029 | 6.223791e-01 | 0.206 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9683610 | 6.223791e-01 | 0.206 | 0 | 0 |
| Replication of the SARS-CoV-1 genome | R-HSA-9682706 | 6.223791e-01 | 0.206 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 6.230427e-01 | 0.205 | 1 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 6.233323e-01 | 0.205 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in apoptosis | R-HSA-9824594 | 6.250291e-01 | 0.204 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 6.250291e-01 | 0.204 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 6.250291e-01 | 0.204 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 6.250291e-01 | 0.204 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 6.291036e-01 | 0.201 | 0 | 0 |
| TYSND1 cleaves peroxisomal proteins | R-HSA-9033500 | 6.291149e-01 | 0.201 | 0 | 0 |
| Plus-strand DNA synthesis | R-HSA-164525 | 6.291149e-01 | 0.201 | 0 | 0 |
| SLIT2:ROBO1 increases RHOA activity | R-HSA-8985586 | 6.291149e-01 | 0.201 | 0 | 0 |
| Defective CSF2RB causes SMDP5 | R-HSA-5688849 | 6.291149e-01 | 0.201 | 0 | 0 |
| Loss of MECP2 binding ability to the NCoR/SMRT complex | R-HSA-9022537 | 6.291149e-01 | 0.201 | 0 | 0 |
| Defective CSF2RA causes SMDP4 | R-HSA-5688890 | 6.291149e-01 | 0.201 | 0 | 0 |
| Release of apoptotic factors from the mitochondria | R-HSA-111457 | 6.291149e-01 | 0.201 | 0 | 0 |
| NGF-independant TRKA activation | R-HSA-187024 | 6.291149e-01 | 0.201 | 0 | 0 |
| PKB-mediated events | R-HSA-109703 | 6.291149e-01 | 0.201 | 0 | 0 |
| CDC6 association with the ORC:origin complex | R-HSA-68689 | 6.291149e-01 | 0.201 | 0 | 0 |
| PDE3B signalling | R-HSA-165160 | 6.291149e-01 | 0.201 | 0 | 0 |
| Signalling to p38 via RIT and RIN | R-HSA-187706 | 6.291149e-01 | 0.201 | 0 | 0 |
| VEGF binds to VEGFR leading to receptor dimerization | R-HSA-195399 | 6.291149e-01 | 0.201 | 0 | 0 |
| VEGF ligand-receptor interactions | R-HSA-194313 | 6.291149e-01 | 0.201 | 0 | 0 |
| Relaxin receptors | R-HSA-444821 | 6.291149e-01 | 0.201 | 0 | 0 |
| Release of Hh-Np from the secreting cell | R-HSA-5362798 | 6.291149e-01 | 0.201 | 0 | 0 |
| Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | R-HSA-2660825 | 6.291149e-01 | 0.201 | 0 | 0 |
| Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | R-HSA-2660826 | 6.291149e-01 | 0.201 | 0 | 0 |
| SLC15A4:TASL-dependent IRF5 activation | R-HSA-9860276 | 6.291149e-01 | 0.201 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 6.299551e-01 | 0.201 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 6.318724e-01 | 0.199 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 6.355661e-01 | 0.197 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 6.355661e-01 | 0.197 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 6.438213e-01 | 0.191 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 6.470924e-01 | 0.189 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 6.499749e-01 | 0.187 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 6.500897e-01 | 0.187 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 6.500897e-01 | 0.187 | 0 | 0 |
| Mitochondrial calcium ion transport | R-HSA-8949215 | 6.500897e-01 | 0.187 | 0 | 0 |
| Assembly Of The HIV Virion | R-HSA-175474 | 6.500897e-01 | 0.187 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 6.515786e-01 | 0.186 | 0 | 0 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | R-HSA-5684264 | 6.531207e-01 | 0.185 | 0 | 0 |
| Removal of the Flap Intermediate | R-HSA-69166 | 6.531207e-01 | 0.185 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR3 | R-HSA-5654227 | 6.531207e-01 | 0.185 | 0 | 0 |
| Synthesis of IPs in the nucleus | R-HSA-1855191 | 6.531207e-01 | 0.185 | 0 | 0 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | R-HSA-174495 | 6.531207e-01 | 0.185 | 0 | 0 |
| Physiological factors | R-HSA-5578768 | 6.531207e-01 | 0.185 | 0 | 0 |
| Non-canonical inflammasome activation | R-HSA-9686114 | 6.531207e-01 | 0.185 | 0 | 0 |
| Glycerophospholipid catabolism | R-HSA-6814848 | 6.531207e-01 | 0.185 | 0 | 0 |
| Zinc transporters | R-HSA-435354 | 6.531207e-01 | 0.185 | 0 | 0 |
| SARS-CoV-1 Genome Replication and Transcription | R-HSA-9679514 | 6.531207e-01 | 0.185 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 6.582083e-01 | 0.182 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 6.588319e-01 | 0.181 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 6.588319e-01 | 0.181 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 6.588319e-01 | 0.181 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 6.631963e-01 | 0.178 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 6.714704e-01 | 0.173 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 6.720209e-01 | 0.173 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 6.722540e-01 | 0.172 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 6.723412e-01 | 0.172 | 0 | 0 |
| Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | R-HSA-3656244 | 6.723733e-01 | 0.172 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 6.723733e-01 | 0.172 | 0 | 0 |
| STAT5 Activation | R-HSA-9645135 | 6.723733e-01 | 0.172 | 0 | 0 |
| Uncoating of the HIV Virion | R-HSA-162585 | 6.723733e-01 | 0.172 | 0 | 0 |
| Defective CHST6 causes MCDC1 | R-HSA-3656225 | 6.723733e-01 | 0.172 | 0 | 0 |
| Defective ST3GAL3 causes MCT12 and EIEE15 | R-HSA-3656243 | 6.723733e-01 | 0.172 | 0 | 0 |
| Defective factor VIII causes hemophilia A | R-HSA-9662001 | 6.723733e-01 | 0.172 | 0 | 0 |
| Signaling by LTK in cancer | R-HSA-9842640 | 6.723733e-01 | 0.172 | 0 | 0 |
| VLDL assembly | R-HSA-8866423 | 6.723733e-01 | 0.172 | 0 | 0 |
| Nef and signal transduction | R-HSA-164944 | 6.723733e-01 | 0.172 | 0 | 0 |
| HDL clearance | R-HSA-8964011 | 6.723733e-01 | 0.172 | 0 | 0 |
| Neurofascin interactions | R-HSA-447043 | 6.723733e-01 | 0.172 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 6.734073e-01 | 0.172 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 6.739312e-01 | 0.171 | 0 | 0 |
| FRS-mediated FGFR4 signaling | R-HSA-5654712 | 6.739312e-01 | 0.171 | 0 | 0 |
| RAF-independent MAPK1/3 activation | R-HSA-112409 | 6.739312e-01 | 0.171 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 6.739312e-01 | 0.171 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 6.757782e-01 | 0.170 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 6.771060e-01 | 0.169 | 0 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 6.771060e-01 | 0.169 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 6.785452e-01 | 0.168 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 6.788437e-01 | 0.168 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 6.788437e-01 | 0.168 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 6.818309e-01 | 0.166 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 6.818309e-01 | 0.166 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 6.818309e-01 | 0.166 | 0 | 0 |
| Translesion synthesis by REV1 | R-HSA-110312 | 6.818309e-01 | 0.166 | 0 | 0 |
| FGFR3 ligand binding and activation | R-HSA-190239 | 6.818309e-01 | 0.166 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 6.818309e-01 | 0.166 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 6.818309e-01 | 0.166 | 0 | 0 |
| Signaling by Activin | R-HSA-1502540 | 6.818309e-01 | 0.166 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 6.818309e-01 | 0.166 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 6.818309e-01 | 0.166 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 6.818309e-01 | 0.166 | 0 | 0 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 6.818309e-01 | 0.166 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 6.859495e-01 | 0.164 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 6.864938e-01 | 0.163 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 6.913203e-01 | 0.160 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 6.913203e-01 | 0.160 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 6.913203e-01 | 0.160 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 6.913203e-01 | 0.160 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 6.940248e-01 | 0.159 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE | R-HSA-77075 | 6.965527e-01 | 0.157 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | R-HSA-167160 | 6.965527e-01 | 0.157 | 0 | 0 |
| Interleukin-20 family signaling | R-HSA-8854691 | 6.965527e-01 | 0.157 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 6.965527e-01 | 0.157 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 6.983273e-01 | 0.156 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 6.983273e-01 | 0.156 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 6.987058e-01 | 0.156 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 6.992875e-01 | 0.155 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 7.085502e-01 | 0.150 | 0 | 0 |
| Translesion synthesis by POLI | R-HSA-5656121 | 7.085654e-01 | 0.150 | 0 | 0 |
| Attachment and Entry | R-HSA-9678110 | 7.085654e-01 | 0.150 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 7.085654e-01 | 0.150 | 0 | 0 |
| Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | R-HSA-9942503 | 7.085654e-01 | 0.150 | 0 | 0 |
| Differentiation of T cells | R-HSA-9945266 | 7.085654e-01 | 0.150 | 0 | 0 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | R-HSA-210744 | 7.085654e-01 | 0.150 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 7.085654e-01 | 0.150 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 7.086224e-01 | 0.150 | 0 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 7.086224e-01 | 0.150 | 0 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 7.087322e-01 | 0.150 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 7.087322e-01 | 0.150 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 7.087322e-01 | 0.150 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 7.087322e-01 | 0.150 | 0 | 0 |
| PP2A-mediated dephosphorylation of key metabolic factors | R-HSA-163767 | 7.105885e-01 | 0.148 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | R-HSA-9031525 | 7.105885e-01 | 0.148 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | R-HSA-9632974 | 7.105885e-01 | 0.148 | 0 | 0 |
| FGFR3b ligand binding and activation | R-HSA-190371 | 7.105885e-01 | 0.148 | 0 | 0 |
| Recycling of eIF2:GDP | R-HSA-72731 | 7.105885e-01 | 0.148 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 7.105885e-01 | 0.148 | 0 | 0 |
| Activated NTRK2 signals through CDK5 | R-HSA-9032845 | 7.105885e-01 | 0.148 | 0 | 0 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | 7.105885e-01 | 0.148 | 0 | 0 |
| VLDL clearance | R-HSA-8964046 | 7.105885e-01 | 0.148 | 0 | 0 |
| LDL remodeling | R-HSA-8964041 | 7.105885e-01 | 0.148 | 0 | 0 |
| Ca2+ activated K+ channels | R-HSA-1296052 | 7.105885e-01 | 0.148 | 0 | 0 |
| Activation of TRKA receptors | R-HSA-187015 | 7.105885e-01 | 0.148 | 0 | 0 |
| Phase 3 - rapid repolarisation | R-HSA-5576890 | 7.105885e-01 | 0.148 | 0 | 0 |
| Nef Mediated CD4 Down-regulation | R-HSA-167590 | 7.105885e-01 | 0.148 | 0 | 0 |
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 7.105885e-01 | 0.148 | 0 | 0 |
| TGFBR3 regulates TGF-beta signaling | R-HSA-9839389 | 7.105885e-01 | 0.148 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 7.112472e-01 | 0.148 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 7.116726e-01 | 0.148 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 7.120726e-01 | 0.147 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 7.158936e-01 | 0.145 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 7.179636e-01 | 0.144 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 1 | R-HSA-418592 | 7.179636e-01 | 0.144 | 0 | 0 |
| Interleukin-6 family signaling | R-HSA-6783589 | 7.179636e-01 | 0.144 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 7.179636e-01 | 0.144 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 7.187023e-01 | 0.143 | 0 | 0 |
| Influenza Infection | R-HSA-168255 | 7.248532e-01 | 0.140 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 7.250934e-01 | 0.140 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 7.285641e-01 | 0.138 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 7.297192e-01 | 0.137 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 7.317015e-01 | 0.136 | 0 | 0 |
| Translesion synthesis by POLK | R-HSA-5655862 | 7.333942e-01 | 0.135 | 0 | 0 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 7.333942e-01 | 0.135 | 1 | 1 |
| Disorders of Developmental Biology | R-HSA-9675151 | 7.333942e-01 | 0.135 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 7.333942e-01 | 0.135 | 0 | 0 |
| SHC1 events in ERBB4 signaling | R-HSA-1250347 | 7.333942e-01 | 0.135 | 0 | 0 |
| Synthesis of PG | R-HSA-1483148 | 7.333942e-01 | 0.135 | 0 | 0 |
| Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | R-HSA-9651496 | 7.333942e-01 | 0.135 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 7.371021e-01 | 0.132 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 7.379740e-01 | 0.132 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 7.379841e-01 | 0.132 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 7.379841e-01 | 0.132 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 7.381820e-01 | 0.132 | 0 | 0 |
| FRS-mediated FGFR1 signaling | R-HSA-5654693 | 7.381820e-01 | 0.132 | 0 | 0 |
| Glycogen breakdown (glycogenolysis) | R-HSA-70221 | 7.381820e-01 | 0.132 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 7.381820e-01 | 0.132 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 7.381820e-01 | 0.132 | 0 | 0 |
| Synthesis of PIPs at the early endosome membrane | R-HSA-1660516 | 7.381820e-01 | 0.132 | 0 | 0 |
| Formation of the nephric duct | R-HSA-9830364 | 7.381820e-01 | 0.132 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 7.381972e-01 | 0.132 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 7.409503e-01 | 0.130 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 7.409503e-01 | 0.130 | 0 | 0 |
| Reverse Transcription of HIV RNA | R-HSA-162589 | 7.443481e-01 | 0.128 | 0 | 0 |
| Minus-strand DNA synthesis | R-HSA-164516 | 7.443481e-01 | 0.128 | 0 | 0 |
| Regulation of NPAS4 mRNA translation | R-HSA-9768778 | 7.443481e-01 | 0.128 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 7.443481e-01 | 0.128 | 0 | 0 |
| Activated NTRK2 signals through PI3K | R-HSA-9028335 | 7.443481e-01 | 0.128 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 7.443481e-01 | 0.128 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of keratinocytes | R-HSA-8939242 | 7.443481e-01 | 0.128 | 0 | 0 |
| Formyl peptide receptors bind formyl peptides and many other ligands | R-HSA-444473 | 7.443481e-01 | 0.128 | 0 | 0 |
| Interleukin-9 signaling | R-HSA-8985947 | 7.443481e-01 | 0.128 | 0 | 0 |
| Negative regulation of activity of TFAP2 (AP-2) family transcription factors | R-HSA-8866904 | 7.443481e-01 | 0.128 | 0 | 0 |
| Co-stimulation by ICOS | R-HSA-9927354 | 7.443481e-01 | 0.128 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 7.443481e-01 | 0.128 | 0 | 0 |
| Adrenoceptors | R-HSA-390696 | 7.443481e-01 | 0.128 | 0 | 0 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | 7.443481e-01 | 0.128 | 0 | 0 |
| Alpha-defensins | R-HSA-1462054 | 7.443481e-01 | 0.128 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 7.443481e-01 | 0.128 | 0 | 0 |
| RSK activation | R-HSA-444257 | 7.443481e-01 | 0.128 | 0 | 0 |
| Activated NTRK2 signals through FYN | R-HSA-9032500 | 7.443481e-01 | 0.128 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 7.443481e-01 | 0.128 | 0 | 0 |
| Interleukin-23 signaling | R-HSA-9020933 | 7.443481e-01 | 0.128 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 7.466615e-01 | 0.127 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 7.466615e-01 | 0.127 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 7.466615e-01 | 0.127 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 7.490430e-01 | 0.125 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 7.499696e-01 | 0.125 | 0 | 0 |
| PLC beta mediated events | R-HSA-112043 | 7.499696e-01 | 0.125 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 7.507657e-01 | 0.124 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 7.521222e-01 | 0.124 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 7.553242e-01 | 0.122 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 7.563982e-01 | 0.121 | 0 | 0 |
| Regulation of FZD by ubiquitination | R-HSA-4641263 | 7.563982e-01 | 0.121 | 0 | 0 |
| Regulation of NPAS4 gene expression | R-HSA-9768759 | 7.563982e-01 | 0.121 | 0 | 0 |
| Uptake and function of anthrax toxins | R-HSA-5210891 | 7.563982e-01 | 0.121 | 0 | 0 |
| Replication of the SARS-CoV-2 genome | R-HSA-9694686 | 7.563982e-01 | 0.121 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 7.572332e-01 | 0.121 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 7.604351e-01 | 0.119 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 7.604486e-01 | 0.119 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 7.630788e-01 | 0.117 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 7.630788e-01 | 0.117 | 0 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 7.641712e-01 | 0.117 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 7.656965e-01 | 0.116 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 7.728029e-01 | 0.112 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 7.741714e-01 | 0.111 | 0 | 0 |
| Regulation of signaling by NODAL | R-HSA-1433617 | 7.741714e-01 | 0.111 | 0 | 0 |
| Activation of the TFAP2 (AP-2) family of transcription factors | R-HSA-8866907 | 7.741714e-01 | 0.111 | 0 | 0 |
| Regulation of NPAS4 gene transcription | R-HSA-9768777 | 7.741714e-01 | 0.111 | 0 | 0 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | R-HSA-428542 | 7.741714e-01 | 0.111 | 0 | 0 |
| Zinc influx into cells by the SLC39 gene family | R-HSA-442380 | 7.741714e-01 | 0.111 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 7.751481e-01 | 0.111 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 7.751481e-01 | 0.111 | 0 | 0 |
| Cytosolic iron-sulfur cluster assembly | R-HSA-2564830 | 7.776652e-01 | 0.109 | 0 | 0 |
| PKA activation | R-HSA-163615 | 7.776652e-01 | 0.109 | 0 | 0 |
| Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 7.776652e-01 | 0.109 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 7.776652e-01 | 0.109 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 7.776652e-01 | 0.109 | 0 | 0 |
| Nephron development | R-HSA-9831926 | 7.776652e-01 | 0.109 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9679504 | 7.776652e-01 | 0.109 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 7.786552e-01 | 0.109 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 7.786552e-01 | 0.109 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 7.786552e-01 | 0.109 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 7.786552e-01 | 0.109 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 7.786552e-01 | 0.109 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 7.787114e-01 | 0.109 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 7.897047e-01 | 0.103 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 7.904937e-01 | 0.102 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 7.911735e-01 | 0.102 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 7.919626e-01 | 0.101 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 7.919626e-01 | 0.101 | 0 | 0 |
| FRS-mediated FGFR2 signaling | R-HSA-5654700 | 7.919626e-01 | 0.101 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 7.972872e-01 | 0.098 | 0 | 0 |
| Diseases of hemostasis | R-HSA-9671793 | 7.972872e-01 | 0.098 | 0 | 0 |
| Specification of the neural plate border | R-HSA-9834899 | 7.972872e-01 | 0.098 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 7.972872e-01 | 0.098 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 7.972872e-01 | 0.098 | 0 | 0 |
| SARS-CoV-2 Genome Replication and Transcription | R-HSA-9694682 | 7.972872e-01 | 0.098 | 0 | 0 |
| Binding and entry of HIV virion | R-HSA-173107 | 8.005173e-01 | 0.097 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 8.005173e-01 | 0.097 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 8.005173e-01 | 0.097 | 0 | 0 |
| Activation of Ca-permeable Kainate Receptor | R-HSA-451308 | 8.005173e-01 | 0.097 | 0 | 0 |
| TET1,2,3 and TDG demethylate DNA | R-HSA-5221030 | 8.005173e-01 | 0.097 | 0 | 0 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | R-HSA-2151209 | 8.005173e-01 | 0.097 | 0 | 0 |
| Ion influx/efflux at host-pathogen interface | R-HSA-6803544 | 8.005173e-01 | 0.097 | 0 | 0 |
| Interleukin-27 signaling | R-HSA-9020956 | 8.005173e-01 | 0.097 | 0 | 0 |
| CASP4 inflammasome assembly | R-HSA-9948001 | 8.005173e-01 | 0.097 | 0 | 0 |
| Arachidonate production from DAG | R-HSA-426048 | 8.005173e-01 | 0.097 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 8.005173e-01 | 0.097 | 0 | 0 |
| Cross-presentation of particulate exogenous antigens (phagosomes) | R-HSA-1236973 | 8.005173e-01 | 0.097 | 0 | 0 |
| Defective factor IX causes hemophilia B | R-HSA-9668250 | 8.005173e-01 | 0.097 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 8.005173e-01 | 0.097 | 0 | 0 |
| Metal sequestration by antimicrobial proteins | R-HSA-6799990 | 8.005173e-01 | 0.097 | 0 | 0 |
| Tandem pore domain potassium channels | R-HSA-1296346 | 8.005173e-01 | 0.097 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 8.030910e-01 | 0.095 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 8.030910e-01 | 0.095 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 8.053112e-01 | 0.094 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 8.072411e-01 | 0.093 | 0 | 0 |
| Interferon alpha/beta signaling | R-HSA-909733 | 8.072674e-01 | 0.093 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 8.073613e-01 | 0.093 | 0 | 0 |
| mRNA Capping | R-HSA-72086 | 8.077159e-01 | 0.093 | 0 | 0 |
| Nitric oxide stimulates guanylate cyclase | R-HSA-392154 | 8.077159e-01 | 0.093 | 0 | 0 |
| Glucagon-type ligand receptors | R-HSA-420092 | 8.077159e-01 | 0.093 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 8.077646e-01 | 0.093 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 8.101605e-01 | 0.091 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 8.101605e-01 | 0.091 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 8.127632e-01 | 0.090 | 1 | 0 |
| Circadian clock | R-HSA-9909396 | 8.148578e-01 | 0.089 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 8.153586e-01 | 0.089 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 8.153586e-01 | 0.089 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 8.153586e-01 | 0.089 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 8.153586e-01 | 0.089 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 8.161282e-01 | 0.088 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 8.173362e-01 | 0.088 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 8.195337e-01 | 0.086 | 0 | 0 |
| RAS processing | R-HSA-9648002 | 8.205358e-01 | 0.086 | 0 | 0 |
| NOTCH3 Intracellular Domain Regulates Transcription | R-HSA-9013508 | 8.224502e-01 | 0.085 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 8.224502e-01 | 0.085 | 0 | 0 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 8.224502e-01 | 0.085 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 8.224502e-01 | 0.085 | 0 | 0 |
| Regulation of CDH11 mRNA translation by microRNAs | R-HSA-9759811 | 8.237908e-01 | 0.084 | 0 | 0 |
| Interleukin-2 signaling | R-HSA-9020558 | 8.237908e-01 | 0.084 | 0 | 0 |
| Ionotropic activity of kainate receptors | R-HSA-451306 | 8.237908e-01 | 0.084 | 0 | 0 |
| vRNA Synthesis | R-HSA-192814 | 8.237908e-01 | 0.084 | 0 | 0 |
| vRNP Assembly | R-HSA-192905 | 8.237908e-01 | 0.084 | 0 | 0 |
| Chylomicron assembly | R-HSA-8963888 | 8.237908e-01 | 0.084 | 0 | 0 |
| Synthesis of PI | R-HSA-1483226 | 8.237908e-01 | 0.084 | 0 | 0 |
| Inorganic anion exchange by SLC26 transporters | R-HSA-427601 | 8.237908e-01 | 0.084 | 0 | 0 |
| LGI-ADAM interactions | R-HSA-5682910 | 8.237908e-01 | 0.084 | 0 | 0 |
| Prostanoid ligand receptors | R-HSA-391908 | 8.237908e-01 | 0.084 | 0 | 0 |
| Dissolution of Fibrin Clot | R-HSA-75205 | 8.237908e-01 | 0.084 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 8.253315e-01 | 0.083 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 8.319741e-01 | 0.080 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 8.319741e-01 | 0.080 | 0 | 0 |
| Intrinsic Pathway of Fibrin Clot Formation | R-HSA-140837 | 8.319741e-01 | 0.080 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 8.319741e-01 | 0.080 | 0 | 0 |
| Prevention of phagosomal-lysosomal fusion | R-HSA-9636383 | 8.319741e-01 | 0.080 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 8.329576e-01 | 0.079 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 8.329576e-01 | 0.079 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 8.329576e-01 | 0.079 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 8.333614e-01 | 0.079 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 8.333614e-01 | 0.079 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 8.356774e-01 | 0.078 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 8.395919e-01 | 0.076 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 8.395919e-01 | 0.076 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 8.415166e-01 | 0.075 | 0 | 0 |
| PI3K events in ERBB4 signaling | R-HSA-1250342 | 8.443503e-01 | 0.073 | 0 | 0 |
| Sensing of DNA Double Strand Breaks | R-HSA-5693548 | 8.443503e-01 | 0.073 | 0 | 0 |
| Endosomal/Vacuolar pathway | R-HSA-1236977 | 8.443503e-01 | 0.073 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 8.443503e-01 | 0.073 | 0 | 0 |
| POLB-Dependent Long Patch Base Excision Repair | R-HSA-110362 | 8.443503e-01 | 0.073 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 8.443503e-01 | 0.073 | 0 | 0 |
| Viral RNP Complexes in the Host Cell Nucleus | R-HSA-168330 | 8.443503e-01 | 0.073 | 0 | 0 |
| Reduction of cytosolic Ca++ levels | R-HSA-418359 | 8.443503e-01 | 0.073 | 0 | 0 |
| Sodium/Calcium exchangers | R-HSA-425561 | 8.443503e-01 | 0.073 | 0 | 0 |
| Synthesis of diphthamide-EEF2 | R-HSA-5358493 | 8.443503e-01 | 0.073 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 8.443503e-01 | 0.073 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 8.455240e-01 | 0.073 | 0 | 0 |
| SHC-mediated cascade:FGFR4 | R-HSA-5654719 | 8.472273e-01 | 0.072 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 8.481537e-01 | 0.072 | 0 | 0 |
| Inwardly rectifying K+ channels | R-HSA-1296065 | 8.490387e-01 | 0.071 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 8.514670e-01 | 0.070 | 0 | 0 |
| Immune System | R-HSA-168256 | 8.524322e-01 | 0.069 | 1 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 8.544013e-01 | 0.068 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 8.556508e-01 | 0.068 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 8.557647e-01 | 0.068 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 8.559335e-01 | 0.068 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 8.568402e-01 | 0.067 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 8.609837e-01 | 0.065 | 0 | 0 |
| Recycling of bile acids and salts | R-HSA-159418 | 8.609837e-01 | 0.065 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 8.609837e-01 | 0.065 | 0 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 8.612098e-01 | 0.065 | 0 | 0 |
| Cellular hexose transport | R-HSA-189200 | 8.612098e-01 | 0.065 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9694676 | 8.612098e-01 | 0.065 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 8.625120e-01 | 0.064 | 0 | 0 |
| Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | R-HSA-9931530 | 8.625120e-01 | 0.064 | 0 | 0 |
| Defective EXT2 causes exostoses 2 | R-HSA-3656237 | 8.625120e-01 | 0.064 | 0 | 0 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | R-HSA-3656253 | 8.625120e-01 | 0.064 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 8.625120e-01 | 0.064 | 0 | 0 |
| Interleukin-15 signaling | R-HSA-8983432 | 8.625120e-01 | 0.064 | 0 | 0 |
| Interleukin-35 Signalling | R-HSA-8984722 | 8.625120e-01 | 0.064 | 0 | 0 |
| Serotonin clearance from the synaptic cleft | R-HSA-380615 | 8.625120e-01 | 0.064 | 0 | 0 |
| Diseases associated with surfactant metabolism | R-HSA-5687613 | 8.625120e-01 | 0.064 | 0 | 0 |
| Role of second messengers in netrin-1 signaling | R-HSA-418890 | 8.625120e-01 | 0.064 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 8.625120e-01 | 0.064 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 8.625120e-01 | 0.064 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 8.625120e-01 | 0.064 | 0 | 0 |
| Erythrocytes take up oxygen and release carbon dioxide | R-HSA-1247673 | 8.625120e-01 | 0.064 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 8.627405e-01 | 0.064 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 8.631457e-01 | 0.064 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 8.637670e-01 | 0.064 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 8.637670e-01 | 0.064 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 8.637670e-01 | 0.064 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 8.637670e-01 | 0.064 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 8.637751e-01 | 0.064 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 8.641650e-01 | 0.063 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 8.659784e-01 | 0.062 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 8.679925e-01 | 0.061 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 8.699829e-01 | 0.060 | 0 | 0 |
| Heme degradation | R-HSA-189483 | 8.720903e-01 | 0.059 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 8.722088e-01 | 0.059 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 8.728069e-01 | 0.059 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 8.728069e-01 | 0.059 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 8.734983e-01 | 0.059 | 0 | 0 |
| Carnitine shuttle | R-HSA-200425 | 8.740104e-01 | 0.058 | 0 | 0 |
| ABC transporters in lipid homeostasis | R-HSA-1369062 | 8.740104e-01 | 0.058 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 8.762158e-01 | 0.057 | 0 | 0 |
| IL-6-type cytokine receptor ligand interactions | R-HSA-6788467 | 8.785555e-01 | 0.056 | 0 | 0 |
| Processing of SMDT1 | R-HSA-8949664 | 8.785555e-01 | 0.056 | 0 | 0 |
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | R-HSA-5676594 | 8.785555e-01 | 0.056 | 0 | 0 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 8.785555e-01 | 0.056 | 0 | 0 |
| rRNA modification in the mitochondrion | R-HSA-6793080 | 8.785555e-01 | 0.056 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 8.786657e-01 | 0.056 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 8.824041e-01 | 0.054 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 8.824041e-01 | 0.054 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 8.847396e-01 | 0.053 | 0 | 0 |
| Translocation of ZAP-70 to Immunological synapse | R-HSA-202430 | 8.857146e-01 | 0.053 | 0 | 0 |
| SHC-mediated cascade:FGFR1 | R-HSA-5654688 | 8.857146e-01 | 0.053 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 8.857146e-01 | 0.053 | 0 | 0 |
| TNFs bind their physiological receptors | R-HSA-5669034 | 8.857146e-01 | 0.053 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 8.893657e-01 | 0.051 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 8.898659e-01 | 0.051 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 8.898659e-01 | 0.051 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 8.919699e-01 | 0.050 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 8.919699e-01 | 0.050 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 8.919699e-01 | 0.050 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 8.927277e-01 | 0.049 | 0 | 0 |
| FGFR3c ligand binding and activation | R-HSA-190372 | 8.927277e-01 | 0.049 | 0 | 0 |
| Prolactin receptor signaling | R-HSA-1170546 | 8.927277e-01 | 0.049 | 0 | 0 |
| Malate-aspartate shuttle | R-HSA-9856872 | 8.927277e-01 | 0.049 | 0 | 0 |
| HDL assembly | R-HSA-8963896 | 8.927277e-01 | 0.049 | 0 | 0 |
| P2Y receptors | R-HSA-417957 | 8.927277e-01 | 0.049 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 8.932311e-01 | 0.049 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 8.950286e-01 | 0.048 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 8.950286e-01 | 0.048 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 8.964037e-01 | 0.047 | 0 | 0 |
| G protein gated Potassium channels | R-HSA-1296059 | 8.964037e-01 | 0.047 | 0 | 0 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | R-HSA-997272 | 8.964037e-01 | 0.047 | 0 | 0 |
| Activation of G protein gated Potassium channels | R-HSA-1296041 | 8.964037e-01 | 0.047 | 0 | 0 |
| Alpha-oxidation of phytanate | R-HSA-389599 | 8.964037e-01 | 0.047 | 0 | 0 |
| Laminin interactions | R-HSA-3000157 | 8.964037e-01 | 0.047 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 9.008315e-01 | 0.045 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 9.008315e-01 | 0.045 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 9.011685e-01 | 0.045 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 9.011685e-01 | 0.045 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 9.013434e-01 | 0.045 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 9.016912e-01 | 0.045 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 9.051612e-01 | 0.043 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 9.051612e-01 | 0.043 | 0 | 0 |
| Competing endogenous RNAs (ceRNAs) regulate PTEN translation | R-HSA-8948700 | 9.052468e-01 | 0.043 | 0 | 0 |
| G beta:gamma signalling through BTK | R-HSA-8964315 | 9.052468e-01 | 0.043 | 0 | 0 |
| Telomere C-strand synthesis initiation | R-HSA-174430 | 9.052468e-01 | 0.043 | 0 | 0 |
| Protein repair | R-HSA-5676934 | 9.052468e-01 | 0.043 | 0 | 0 |
| Lysosphingolipid and LPA receptors | R-HSA-419408 | 9.052468e-01 | 0.043 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 9.052468e-01 | 0.043 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 9.052468e-01 | 0.043 | 0 | 0 |
| Biotin transport and metabolism | R-HSA-196780 | 9.052468e-01 | 0.043 | 0 | 0 |
| MET activates PTK2 signaling | R-HSA-8874081 | 9.061554e-01 | 0.043 | 0 | 0 |
| Urea cycle | R-HSA-70635 | 9.061554e-01 | 0.043 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 9.061554e-01 | 0.043 | 0 | 0 |
| Suppression of phagosomal maturation | R-HSA-9637687 | 9.061554e-01 | 0.043 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 9.065725e-01 | 0.043 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 9.068810e-01 | 0.042 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 9.071609e-01 | 0.042 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 9.090317e-01 | 0.041 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 9.094825e-01 | 0.041 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 9.148239e-01 | 0.039 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 9.150427e-01 | 0.039 | 0 | 0 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 9.150427e-01 | 0.039 | 0 | 0 |
| Synthesis of bile acids and bile salts via 27-hydroxycholesterol | R-HSA-193807 | 9.150427e-01 | 0.039 | 0 | 0 |
| SHC-mediated cascade:FGFR2 | R-HSA-5654699 | 9.150427e-01 | 0.039 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 9.150427e-01 | 0.039 | 0 | 0 |
| Class I peroxisomal membrane protein import | R-HSA-9603798 | 9.163055e-01 | 0.038 | 0 | 0 |
| Phase 4 - resting membrane potential | R-HSA-5576886 | 9.163055e-01 | 0.038 | 0 | 0 |
| Activation of the phototransduction cascade | R-HSA-2485179 | 9.163055e-01 | 0.038 | 0 | 0 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | R-HSA-9634600 | 9.163055e-01 | 0.038 | 0 | 0 |
| Fructose catabolism | R-HSA-70350 | 9.163055e-01 | 0.038 | 0 | 0 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | R-HSA-6803207 | 9.163055e-01 | 0.038 | 0 | 0 |
| Atorvastatin ADME | R-HSA-9754706 | 9.163055e-01 | 0.038 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 9.170556e-01 | 0.038 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 9.173701e-01 | 0.037 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 9.188254e-01 | 0.037 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 9.188254e-01 | 0.037 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 9.188254e-01 | 0.037 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 9.196057e-01 | 0.036 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 9.206119e-01 | 0.036 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 9.221050e-01 | 0.035 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 9.229198e-01 | 0.035 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 9.231345e-01 | 0.035 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 9.231345e-01 | 0.035 | 0 | 0 |
| ATF4 activates genes in response to endoplasmic reticulum stress | R-HSA-380994 | 9.231345e-01 | 0.035 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 9.232439e-01 | 0.035 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 9.236114e-01 | 0.035 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | R-HSA-381771 | 9.236114e-01 | 0.035 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 9.236114e-01 | 0.035 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 9.236114e-01 | 0.035 | 0 | 0 |
| Defective B4GALT7 causes EDS, progeroid type | R-HSA-3560783 | 9.260741e-01 | 0.033 | 0 | 0 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | R-HSA-4420332 | 9.260741e-01 | 0.033 | 0 | 0 |
| G beta:gamma signalling through CDC42 | R-HSA-8964616 | 9.260741e-01 | 0.033 | 0 | 0 |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | R-HSA-975110 | 9.260741e-01 | 0.033 | 0 | 0 |
| STAT5 activation downstream of FLT3 ITD mutants | R-HSA-9702518 | 9.260741e-01 | 0.033 | 0 | 0 |
| Biosynthesis of maresin-like SPMs | R-HSA-9027307 | 9.260741e-01 | 0.033 | 0 | 0 |
| Heme assimilation | R-HSA-9927020 | 9.260741e-01 | 0.033 | 0 | 0 |
| Phase 2 - plateau phase | R-HSA-5576893 | 9.260741e-01 | 0.033 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 9.260741e-01 | 0.033 | 0 | 0 |
| Galactose catabolism | R-HSA-70370 | 9.260741e-01 | 0.033 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | R-HSA-400511 | 9.260741e-01 | 0.033 | 0 | 0 |
| tRNA modification in the mitochondrion | R-HSA-6787450 | 9.260741e-01 | 0.033 | 0 | 0 |
| Transcriptional regulation of testis differentiation | R-HSA-9690406 | 9.260741e-01 | 0.033 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 9.267136e-01 | 0.033 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 9.272082e-01 | 0.033 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 9.272082e-01 | 0.033 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 9.279333e-01 | 0.032 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 9.279936e-01 | 0.032 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 9.279936e-01 | 0.032 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 9.279936e-01 | 0.032 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 9.281799e-01 | 0.032 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 9.300689e-01 | 0.031 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 9.300689e-01 | 0.031 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 9.304955e-01 | 0.031 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 9.304955e-01 | 0.031 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 9.335121e-01 | 0.030 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 9.335121e-01 | 0.030 | 0 | 0 |
| Defective B3GAT3 causes JDSSDHD | R-HSA-3560801 | 9.347030e-01 | 0.029 | 0 | 0 |
| Catecholamine biosynthesis | R-HSA-209905 | 9.347030e-01 | 0.029 | 0 | 0 |
| Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | R-HSA-2408550 | 9.347030e-01 | 0.029 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 9.347836e-01 | 0.029 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 9.356557e-01 | 0.029 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 9.360205e-01 | 0.029 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 9.360205e-01 | 0.029 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 9.360205e-01 | 0.029 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 9.371859e-01 | 0.028 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 9.371859e-01 | 0.028 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 9.386966e-01 | 0.027 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 9.415010e-01 | 0.026 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 9.423252e-01 | 0.026 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 9.423252e-01 | 0.026 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 9.423252e-01 | 0.026 | 0 | 0 |
| Synaptic adhesion-like molecules | R-HSA-8849932 | 9.423252e-01 | 0.026 | 0 | 0 |
| Nucleotide-like (purinergic) receptors | R-HSA-418038 | 9.423252e-01 | 0.026 | 0 | 0 |
| Vitamin D (calciferol) metabolism | R-HSA-196791 | 9.423252e-01 | 0.026 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 9.432620e-01 | 0.025 | 0 | 0 |
| Cargo concentration in the ER | R-HSA-5694530 | 9.432620e-01 | 0.025 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 9.432620e-01 | 0.025 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 9.435014e-01 | 0.025 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 9.458884e-01 | 0.024 | 0 | 0 |
| Incretin synthesis, secretion, and inactivation | R-HSA-400508 | 9.465434e-01 | 0.024 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 9.465434e-01 | 0.024 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 9.465434e-01 | 0.024 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 9.470265e-01 | 0.024 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 9.479766e-01 | 0.023 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 9.487759e-01 | 0.023 | 0 | 0 |
| Prostacyclin signalling through prostacyclin receptor | R-HSA-392851 | 9.490580e-01 | 0.023 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 9.490580e-01 | 0.023 | 0 | 0 |
| Erythrocytes take up carbon dioxide and release oxygen | R-HSA-1237044 | 9.490580e-01 | 0.023 | 0 | 0 |
| O2/CO2 exchange in erythrocytes | R-HSA-1480926 | 9.490580e-01 | 0.023 | 0 | 0 |
| Pre-NOTCH Processing in Golgi | R-HSA-1912420 | 9.490580e-01 | 0.023 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 9.490580e-01 | 0.023 | 0 | 0 |
| Crosslinking of collagen fibrils | R-HSA-2243919 | 9.490580e-01 | 0.023 | 0 | 0 |
| Response of Mtb to phagocytosis | R-HSA-9637690 | 9.511789e-01 | 0.022 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 9.534527e-01 | 0.021 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 9.537761e-01 | 0.021 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 9.540463e-01 | 0.020 | 0 | 0 |
| Regulation of PD-L1(CD274) translation | R-HSA-9909620 | 9.550052e-01 | 0.020 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 9.550052e-01 | 0.020 | 0 | 0 |
| Acyl chain remodelling of PI | R-HSA-1482922 | 9.550052e-01 | 0.020 | 0 | 0 |
| Keratan sulfate degradation | R-HSA-2022857 | 9.550052e-01 | 0.020 | 0 | 0 |
| Melanin biosynthesis | R-HSA-5662702 | 9.550052e-01 | 0.020 | 0 | 0 |
| Creatine metabolism | R-HSA-71288 | 9.550052e-01 | 0.020 | 0 | 0 |
| Pregnenolone biosynthesis | R-HSA-196108 | 9.550052e-01 | 0.020 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 9.550052e-01 | 0.020 | 0 | 0 |
| Eicosanoid ligand-binding receptors | R-HSA-391903 | 9.550052e-01 | 0.020 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 9.550052e-01 | 0.020 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 9.556426e-01 | 0.020 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 9.583074e-01 | 0.018 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 9.583074e-01 | 0.018 | 0 | 0 |
| Glutamate and glutamine metabolism | R-HSA-8964539 | 9.583074e-01 | 0.018 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 9.593453e-01 | 0.018 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 9.593453e-01 | 0.018 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 9.593453e-01 | 0.018 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.595014e-01 | 0.018 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 9.598150e-01 | 0.018 | 1 | 0 |
| G-protein activation | R-HSA-202040 | 9.602585e-01 | 0.018 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 12 | R-HSA-392170 | 9.602585e-01 | 0.018 | 0 | 0 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 9.602585e-01 | 0.018 | 0 | 0 |
| PD-L1(CD274) glycosylation and translocation to plasma membrane | R-HSA-9931295 | 9.602585e-01 | 0.018 | 0 | 0 |
| Synthesis, secretion, and deacylation of Ghrelin | R-HSA-422085 | 9.602585e-01 | 0.018 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 9.610662e-01 | 0.017 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 9.624111e-01 | 0.017 | 0 | 0 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | R-HSA-6814122 | 9.624111e-01 | 0.017 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 9.624111e-01 | 0.017 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 9.629300e-01 | 0.016 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 9.629300e-01 | 0.016 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 9.637198e-01 | 0.016 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 9.648986e-01 | 0.016 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 9.648986e-01 | 0.016 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 9.648986e-01 | 0.016 | 0 | 0 |
| Inactivation of CSF3 (G-CSF) signaling | R-HSA-9705462 | 9.648986e-01 | 0.016 | 0 | 0 |
| Metabolism of Angiotensinogen to Angiotensins | R-HSA-2022377 | 9.648986e-01 | 0.016 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 9.658191e-01 | 0.015 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 9.658191e-01 | 0.015 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 9.661251e-01 | 0.015 | 0 | 0 |
| Synthesis of bile acids and bile salts via 24-hydroxycholesterol | R-HSA-193775 | 9.661251e-01 | 0.015 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 9.662083e-01 | 0.015 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 9.685404e-01 | 0.014 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 9.686219e-01 | 0.014 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 9.687296e-01 | 0.014 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy | R-HSA-9857377 | 9.689972e-01 | 0.014 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | R-HSA-76071 | 9.689972e-01 | 0.014 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 9.689972e-01 | 0.014 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 9.689972e-01 | 0.014 | 0 | 0 |
| Fructose metabolism | R-HSA-5652084 | 9.689972e-01 | 0.014 | 0 | 0 |
| Ethanol oxidation | R-HSA-71384 | 9.689972e-01 | 0.014 | 0 | 0 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | R-HSA-6803205 | 9.689972e-01 | 0.014 | 0 | 0 |
| LDL clearance | R-HSA-8964038 | 9.689972e-01 | 0.014 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 9.692249e-01 | 0.014 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 9.692249e-01 | 0.014 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 9.692408e-01 | 0.014 | 0 | 0 |
| Glycosphingolipid transport | R-HSA-9845576 | 9.694846e-01 | 0.013 | 0 | 0 |
| Triglyceride catabolism | R-HSA-163560 | 9.694846e-01 | 0.013 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 9.694846e-01 | 0.013 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.696193e-01 | 0.013 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 9.712090e-01 | 0.013 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 9.720758e-01 | 0.012 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 9.725217e-01 | 0.012 | 0 | 0 |
| Voltage gated Potassium channels | R-HSA-1296072 | 9.725217e-01 | 0.012 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 9.725217e-01 | 0.012 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 9.725217e-01 | 0.012 | 0 | 0 |
| SLC-mediated transport of organic cations | R-HSA-549127 | 9.725217e-01 | 0.012 | 0 | 0 |
| Metabolism of folate and pterines | R-HSA-196757 | 9.725217e-01 | 0.012 | 0 | 0 |
| Regulation of PTEN mRNA translation | R-HSA-8943723 | 9.726175e-01 | 0.012 | 0 | 0 |
| Organic anion transport by SLCO transporters | R-HSA-879518 | 9.726175e-01 | 0.012 | 0 | 0 |
| Biosynthesis of maresins | R-HSA-9018682 | 9.726175e-01 | 0.012 | 0 | 0 |
| Formation of the ureteric bud | R-HSA-9830674 | 9.726175e-01 | 0.012 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 9.734900e-01 | 0.012 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 9.747529e-01 | 0.011 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 9.747529e-01 | 0.011 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 9.750409e-01 | 0.011 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 9.751267e-01 | 0.011 | 0 | 0 |
| Depurination | R-HSA-73927 | 9.752659e-01 | 0.011 | 0 | 0 |
| CYP2E1 reactions | R-HSA-211999 | 9.758152e-01 | 0.011 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 9.758152e-01 | 0.011 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 9.768026e-01 | 0.010 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 9.777180e-01 | 0.010 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 9.777440e-01 | 0.010 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 9.777440e-01 | 0.010 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 9.777440e-01 | 0.010 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 9.777440e-01 | 0.010 | 0 | 0 |
| MicroRNA (miRNA) biogenesis | R-HSA-203927 | 9.786396e-01 | 0.009 | 0 | 0 |
| PIWI-interacting RNA (piRNA) biogenesis | R-HSA-5601884 | 9.786396e-01 | 0.009 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 9.789071e-01 | 0.009 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 9.789071e-01 | 0.009 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 9.794459e-01 | 0.009 | 1 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 9.795670e-01 | 0.009 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 9.796368e-01 | 0.009 | 0 | 0 |
| Maturation of TCA enzymes and regulation of TCA cycle | R-HSA-9854311 | 9.799809e-01 | 0.009 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 9.799809e-01 | 0.009 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 9.802198e-01 | 0.009 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 9.808288e-01 | 0.008 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 9.811343e-01 | 0.008 | 0 | 0 |
| Linoleic acid (LA) metabolism | R-HSA-2046105 | 9.811343e-01 | 0.008 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 9.811608e-01 | 0.008 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 9.819990e-01 | 0.008 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 9.819990e-01 | 0.008 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 9.819990e-01 | 0.008 | 0 | 0 |
| Purine ribonucleoside monophosphate biosynthesis | R-HSA-73817 | 9.819990e-01 | 0.008 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 9.825826e-01 | 0.008 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 9.833378e-01 | 0.007 | 0 | 0 |
| ER Quality Control Compartment (ERQC) | R-HSA-901032 | 9.833378e-01 | 0.007 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 9.833378e-01 | 0.007 | 0 | 0 |
| Maturation of hRSV A proteins | R-HSA-9828806 | 9.833378e-01 | 0.007 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 9.837886e-01 | 0.007 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 9.838190e-01 | 0.007 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 9.838190e-01 | 0.007 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 9.838190e-01 | 0.007 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 9.838190e-01 | 0.007 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 9.843832e-01 | 0.007 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 9.852841e-01 | 0.006 | 0 | 0 |
| Pyrimidine salvage | R-HSA-73614 | 9.852841e-01 | 0.006 | 0 | 0 |
| Activation of GABAB receptors | R-HSA-991365 | 9.854595e-01 | 0.006 | 0 | 0 |
| GABA B receptor activation | R-HSA-977444 | 9.854595e-01 | 0.006 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 9.867570e-01 | 0.006 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 9.869377e-01 | 0.006 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 9.869377e-01 | 0.006 | 0 | 0 |
| DNA methylation | R-HSA-5334118 | 9.870031e-01 | 0.006 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 9.875018e-01 | 0.005 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 9.876791e-01 | 0.005 | 0 | 0 |
| Neurotransmitter clearance | R-HSA-112311 | 9.885214e-01 | 0.005 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 9.886677e-01 | 0.005 | 0 | 0 |
| Interconversion of nucleotide di- and triphosphates | R-HSA-499943 | 9.891481e-01 | 0.005 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 9.892812e-01 | 0.005 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 9.893919e-01 | 0.005 | 0 | 0 |
| Diseases associated with glycosaminoglycan metabolism | R-HSA-3560782 | 9.894677e-01 | 0.005 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 9.894677e-01 | 0.005 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 9.894677e-01 | 0.005 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 9.894677e-01 | 0.005 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 9.894677e-01 | 0.005 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 9.895507e-01 | 0.005 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 9.896120e-01 | 0.005 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 9.898624e-01 | 0.004 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.901551e-01 | 0.004 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 9.903685e-01 | 0.004 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 9.903685e-01 | 0.004 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 9.904309e-01 | 0.004 | 0 | 0 |
| Regulation of pyruvate metabolism | R-HSA-9861718 | 9.905465e-01 | 0.004 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 9.910468e-01 | 0.004 | 0 | 0 |
| HS-GAG degradation | R-HSA-2024096 | 9.910468e-01 | 0.004 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 9.910468e-01 | 0.004 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 9.911952e-01 | 0.004 | 0 | 0 |
| Citric acid cycle (TCA cycle) | R-HSA-71403 | 9.917526e-01 | 0.004 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 9.917526e-01 | 0.004 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 9.918439e-01 | 0.004 | 0 | 0 |
| Defective B3GALTL causes PpS | R-HSA-5083635 | 9.920929e-01 | 0.003 | 0 | 0 |
| Keratan sulfate biosynthesis | R-HSA-2022854 | 9.920929e-01 | 0.003 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 9.920929e-01 | 0.003 | 0 | 0 |
| Diseases associated with glycosylation precursor biosynthesis | R-HSA-5609975 | 9.920929e-01 | 0.003 | 0 | 0 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 9.930168e-01 | 0.003 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 9.930168e-01 | 0.003 | 0 | 0 |
| Vitamin B5 (pantothenate) metabolism | R-HSA-199220 | 9.930168e-01 | 0.003 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 9.931748e-01 | 0.003 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 9.934612e-01 | 0.003 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 9.937517e-01 | 0.003 | 0 | 0 |
| Glycosaminoglycan-protein linkage region biosynthesis | R-HSA-1971475 | 9.938328e-01 | 0.003 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 9.938328e-01 | 0.003 | 0 | 0 |
| Calnexin/calreticulin cycle | R-HSA-901042 | 9.938328e-01 | 0.003 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 9.938328e-01 | 0.003 | 0 | 0 |
| RA biosynthesis pathway | R-HSA-5365859 | 9.938328e-01 | 0.003 | 0 | 0 |
| Azathioprine ADME | R-HSA-9748787 | 9.938801e-01 | 0.003 | 0 | 0 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | R-HSA-2162123 | 9.938801e-01 | 0.003 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 9.941894e-01 | 0.003 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 9.945535e-01 | 0.002 | 0 | 0 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 9.945535e-01 | 0.002 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 9.951576e-01 | 0.002 | 0 | 0 |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | R-HSA-193368 | 9.951576e-01 | 0.002 | 0 | 0 |
| HS-GAG biosynthesis | R-HSA-2022928 | 9.951900e-01 | 0.002 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 9.951900e-01 | 0.002 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 9.951900e-01 | 0.002 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 9.953808e-01 | 0.002 | 0 | 0 |
| Nucleotide biosynthesis | R-HSA-8956320 | 9.955943e-01 | 0.002 | 0 | 0 |
| O-glycosylation of TSR domain-containing proteins | R-HSA-5173214 | 9.957522e-01 | 0.002 | 0 | 0 |
| Beta-oxidation of very long chain fatty acids | R-HSA-390247 | 9.957522e-01 | 0.002 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.960381e-01 | 0.002 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 9.962487e-01 | 0.002 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 9.962487e-01 | 0.002 | 0 | 0 |
| alpha-linolenic acid (ALA) metabolism | R-HSA-2046106 | 9.962487e-01 | 0.002 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.964232e-01 | 0.002 | 0 | 0 |
| Paracetamol ADME | R-HSA-9753281 | 9.964650e-01 | 0.002 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 9.966872e-01 | 0.001 | 0 | 0 |
| Metabolism of porphyrins | R-HSA-189445 | 9.967685e-01 | 0.001 | 0 | 0 |
| rRNA processing in the mitochondrion | R-HSA-8868766 | 9.970744e-01 | 0.001 | 0 | 0 |
| Tryptophan catabolism | R-HSA-71240 | 9.970744e-01 | 0.001 | 0 | 0 |
| Mitochondrial tRNA aminoacylation | R-HSA-379726 | 9.970744e-01 | 0.001 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.971971e-01 | 0.001 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 9.974276e-01 | 0.001 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 9.974516e-01 | 0.001 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.975025e-01 | 0.001 | 0 | 0 |
| Scavenging by Class A Receptors | R-HSA-3000480 | 9.977185e-01 | 0.001 | 0 | 0 |
| Triglyceride metabolism | R-HSA-8979227 | 9.977297e-01 | 0.001 | 0 | 0 |
| Signaling by Retinoic Acid | R-HSA-5362517 | 9.979686e-01 | 0.001 | 0 | 0 |
| GABA receptor activation | R-HSA-977443 | 9.979686e-01 | 0.001 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 9.979988e-01 | 0.001 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 9.980371e-01 | 0.001 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 9.980812e-01 | 0.001 | 0 | 0 |
| Endogenous sterols | R-HSA-211976 | 9.981827e-01 | 0.001 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 9.981833e-01 | 0.001 | 0 | 0 |
| Defensins | R-HSA-1461973 | 9.982208e-01 | 0.001 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 9.983745e-01 | 0.001 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 9.984038e-01 | 0.001 | 0 | 0 |
| Interleukin-10 signaling | R-HSA-6783783 | 9.984237e-01 | 0.001 | 0 | 0 |
| Amine ligand-binding receptors | R-HSA-375280 | 9.984288e-01 | 0.001 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 9.984288e-01 | 0.001 | 0 | 0 |
| Methylation | R-HSA-156581 | 9.984288e-01 | 0.001 | 0 | 0 |
| Surfactant metabolism | R-HSA-5683826 | 9.984288e-01 | 0.001 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 9.986429e-01 | 0.001 | 0 | 0 |
| Xenobiotics | R-HSA-211981 | 9.987002e-01 | 0.001 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.988696e-01 | 0.000 | 0 | 0 |
| Synthesis of PC | R-HSA-1483191 | 9.989181e-01 | 0.000 | 0 | 0 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | R-HSA-2046104 | 9.989181e-01 | 0.000 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.989613e-01 | 0.000 | 0 | 0 |
| Plasma lipoprotein remodeling | R-HSA-8963899 | 9.990446e-01 | 0.000 | 0 | 0 |
| Nicotinate metabolism | R-HSA-196807 | 9.990717e-01 | 0.000 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 9.990867e-01 | 0.000 | 0 | 0 |
| Keratan sulfate/keratin metabolism | R-HSA-1638074 | 9.991564e-01 | 0.000 | 0 | 0 |
| Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 9.991695e-01 | 0.000 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.991704e-01 | 0.000 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 9.992946e-01 | 0.000 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 9.993379e-01 | 0.000 | 0 | 0 |
| Complex IV assembly | R-HSA-9864848 | 9.993422e-01 | 0.000 | 0 | 0 |
| Cytosolic sulfonation of small molecules | R-HSA-156584 | 9.993422e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.993831e-01 | 0.000 | 0 | 0 |
| Retinoid metabolism and transport | R-HSA-975634 | 9.994086e-01 | 0.000 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 9.994086e-01 | 0.000 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.995426e-01 | 0.000 | 0 | 0 |
| ROS and RNS production in phagocytes | R-HSA-1222556 | 9.995789e-01 | 0.000 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 9.995962e-01 | 0.000 | 0 | 0 |
| Metabolism of amine-derived hormones | R-HSA-209776 | 9.996469e-01 | 0.000 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 9.996727e-01 | 0.000 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.996882e-01 | 0.000 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 9.997290e-01 | 0.000 | 0 | 0 |
| Cholesterol biosynthesis | R-HSA-191273 | 9.997328e-01 | 0.000 | 0 | 0 |
| Heparan sulfate/heparin (HS-GAG) metabolism | R-HSA-1638091 | 9.997569e-01 | 0.000 | 0 | 0 |
| Sialic acid metabolism | R-HSA-4085001 | 9.997569e-01 | 0.000 | 0 | 0 |
| Glutathione conjugation | R-HSA-156590 | 9.997854e-01 | 0.000 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 9.997854e-01 | 0.000 | 0 | 0 |
| Metabolism of fat-soluble vitamins | R-HSA-6806667 | 9.998102e-01 | 0.000 | 0 | 0 |
| Nucleotide salvage | R-HSA-8956321 | 9.998105e-01 | 0.000 | 0 | 0 |
| Collagen degradation | R-HSA-1442490 | 9.998105e-01 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 9.998326e-01 | 0.000 | 0 | 0 |
| Antimicrobial peptides | R-HSA-6803157 | 9.998336e-01 | 0.000 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.998381e-01 | 0.000 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.998381e-01 | 0.000 | 0 | 0 |
| Peroxisomal lipid metabolism | R-HSA-390918 | 9.998654e-01 | 0.000 | 0 | 0 |
| Translation | R-HSA-72766 | 9.999028e-01 | 0.000 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.999046e-01 | 0.000 | 0 | 0 |
| Metabolism of steroid hormones | R-HSA-196071 | 9.999102e-01 | 0.000 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 9.999150e-01 | 0.000 | 0 | 0 |
| Glycosphingolipid catabolism | R-HSA-9840310 | 9.999382e-01 | 0.000 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 9.999388e-01 | 0.000 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.999393e-01 | 0.000 | 0 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.999454e-01 | 0.000 | 0 | 0 |
| Metal ion assimilation from the host | R-HSA-9638482 | 9.999454e-01 | 0.000 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.999454e-01 | 0.000 | 0 | 0 |
| Aspirin ADME | R-HSA-9749641 | 9.999575e-01 | 0.000 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 9.999575e-01 | 0.000 | 0 | 0 |
| Sensory perception of sweet, bitter, and umami (glutamate) taste | R-HSA-9717207 | 9.999607e-01 | 0.000 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 9.999610e-01 | 0.000 | 0 | 0 |
| FCGR activation | R-HSA-2029481 | 9.999621e-01 | 0.000 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.999629e-01 | 0.000 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 9.999636e-01 | 0.000 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 9.999647e-01 | 0.000 | 1 | 0 |
| SLC-mediated transport of organic anions | R-HSA-9955298 | 9.999772e-01 | 0.000 | 0 | 0 |
| Biosynthesis of DHA-derived SPMs | R-HSA-9018677 | 9.999843e-01 | 0.000 | 0 | 0 |
| Sensory perception of taste | R-HSA-9717189 | 9.999863e-01 | 0.000 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.999891e-01 | 0.000 | 0 | 0 |
| Post-translational modification: synthesis of GPI-anchored proteins | R-HSA-163125 | 9.999916e-01 | 0.000 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.999919e-01 | 0.000 | 0 | 0 |
| Disease | R-HSA-1643685 | 9.999933e-01 | 0.000 | 1 | 0 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | R-HSA-420499 | 9.999942e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.999960e-01 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 9.999966e-01 | 0.000 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 9.999980e-01 | 0.000 | 0 | 0 |
| Scavenging of heme from plasma | R-HSA-2168880 | 9.999981e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation elongation | R-HSA-5389840 | 9.999983e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation initiation | R-HSA-5368286 | 9.999987e-01 | 0.000 | 0 | 0 |
| Mitochondrial ribosome-associated quality control | R-HSA-9937383 | 9.999993e-01 | 0.000 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 9.999996e-01 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 9.999997e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation termination | R-HSA-5419276 | 9.999997e-01 | 0.000 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 9.999998e-01 | 0.000 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.999999e-01 | 0.000 | 0 | 0 |
| O-linked glycosylation | R-HSA-5173105 | 9.999999e-01 | 0.000 | 0 | 0 |
| Glycosphingolipid metabolism | R-HSA-1660662 | 1.000000e+00 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 1.000000e+00 | 0.000 | 0 | 0 |
| Regulation of Complement cascade | R-HSA-977606 | 1.000000e+00 | 0.000 | 0 | 0 |
| Cytochrome P450 - arranged by substrate type | R-HSA-211897 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 1.000000e+00 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 1.000000e+00 | 0.000 | 0 | 0 |
| Synthesis of substrates in N-glycan biosythesis | R-HSA-446219 | 1.000000e+00 | 0.000 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 1.000000e+00 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 1.000000e+00 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 1.000000e+00 | 0.000 | 0 | 0 |
| Mitochondrial translation | R-HSA-5368287 | 1.000000e+00 | 0.000 | 0 | 0 |
| Biosynthesis of specialized proresolving mediators (SPMs) | R-HSA-9018678 | 1.000000e+00 | 0.000 | 0 | 0 |
| Complement cascade | R-HSA-166658 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 1.000000e+00 | 0.000 | 0 | 0 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | R-HSA-446193 | 1.000000e+00 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 1.000000e+00 | 0.000 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 1.000000e+00 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase I - Functionalization of compounds | R-HSA-211945 | 1.000000e+00 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase II - Conjugation of compounds | R-HSA-156580 | 1.000000e+00 | 0.000 | 0 | 0 |
| Infection with Enterobacteria | R-HSA-9640148 | 1.000000e+00 | 0.000 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| Expression and translocation of olfactory receptors | R-HSA-9752946 | 1.000000e+00 | -0.000 | 0 | 0 |
| Olfactory Signaling Pathway | R-HSA-381753 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | -0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 1.000000e+00 | -0.000 | 0 | 0 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| Cellular response to heat stress | R-HSA-3371556 | 1.110223e-16 | 15.955 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 2.220446e-15 | 14.654 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 1.100231e-13 | 12.959 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 3.689271e-13 | 12.433 | 0 | 0 |
| HSF1 activation | R-HSA-3371511 | 6.307177e-13 | 12.200 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 5.904166e-13 | 12.229 | 0 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 1.841527e-12 | 11.735 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 1.786016e-12 | 11.748 | 0 | 0 |
| Cell Cycle | R-HSA-1640170 | 9.924950e-12 | 11.003 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 2.318834e-11 | 10.635 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 1.323198e-10 | 9.878 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 1.525973e-10 | 9.816 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 2.284269e-10 | 9.641 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 3.386277e-10 | 9.470 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 5.025109e-10 | 9.299 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 1.081631e-09 | 8.966 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 1.505222e-09 | 8.822 | 1 | 0 |
| Membrane Trafficking | R-HSA-199991 | 1.638448e-09 | 8.786 | 0 | 0 |
| M Phase | R-HSA-68886 | 3.764787e-09 | 8.424 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 4.431173e-09 | 8.353 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 4.854079e-09 | 8.314 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 5.758198e-09 | 8.240 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 9.479706e-09 | 8.023 | 1 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 1.109425e-08 | 7.955 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 2.132493e-08 | 7.671 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 2.344000e-08 | 7.630 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 2.417531e-08 | 7.617 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 3.401986e-08 | 7.468 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 4.320882e-08 | 7.364 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 6.480071e-08 | 7.188 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 8.738888e-08 | 7.059 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 1.099125e-07 | 6.959 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 1.233076e-07 | 6.909 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 2.427276e-07 | 6.615 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 2.580056e-07 | 6.588 | 0 | 0 |
| Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 3.273981e-07 | 6.485 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 3.142581e-07 | 6.503 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 3.269260e-07 | 6.486 | 0 | 0 |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | R-HSA-190840 | 4.513134e-07 | 6.346 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 6.543683e-07 | 6.184 | 0 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 6.617359e-07 | 6.179 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 7.143720e-07 | 6.146 | 0 | 0 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 7.213326e-07 | 6.142 | 0 | 0 |
| Transport of connexons to the plasma membrane | R-HSA-190872 | 7.143720e-07 | 6.146 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 7.624368e-07 | 6.118 | 0 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 8.269352e-07 | 6.083 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 8.607837e-07 | 6.065 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 1.040092e-06 | 5.983 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 1.087494e-06 | 5.964 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 1.215356e-06 | 5.915 | 0 | 0 |
| Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 1.321442e-06 | 5.879 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 1.399851e-06 | 5.854 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 1.631872e-06 | 5.787 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 1.635327e-06 | 5.786 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 1.882042e-06 | 5.725 | 1 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 1.991904e-06 | 5.701 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 1.991904e-06 | 5.701 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 2.117321e-06 | 5.674 | 1 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 2.295403e-06 | 5.639 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 2.778942e-06 | 5.556 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 2.683423e-06 | 5.571 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 2.887421e-06 | 5.539 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 2.868350e-06 | 5.542 | 1 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.334110e-06 | 5.477 | 1 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 3.637955e-06 | 5.439 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 3.989478e-06 | 5.399 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 4.250119e-06 | 5.372 | 0 | 0 |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | R-HSA-9828211 | 4.775980e-06 | 5.321 | 1 | 1 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 5.051573e-06 | 5.297 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 5.739303e-06 | 5.241 | 1 | 1 |
| NF-kB is activated and signals survival | R-HSA-209560 | 5.739303e-06 | 5.241 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 5.839059e-06 | 5.234 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 6.320074e-06 | 5.199 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 6.320074e-06 | 5.199 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 8.389417e-06 | 5.076 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 9.416463e-06 | 5.026 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 9.543127e-06 | 5.020 | 0 | 0 |
| Post-chaperonin tubulin folding pathway | R-HSA-389977 | 1.003415e-05 | 4.999 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 1.046065e-05 | 4.980 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 1.046065e-05 | 4.980 | 0 | 0 |
| Gap junction assembly | R-HSA-190861 | 1.141189e-05 | 4.943 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 1.170704e-05 | 4.932 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 1.292056e-05 | 4.889 | 1 | 1 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 1.384710e-05 | 4.859 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 1.730791e-05 | 4.762 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 1.980536e-05 | 4.703 | 1 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 2.044723e-05 | 4.689 | 1 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 2.103224e-05 | 4.677 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 2.196961e-05 | 4.658 | 1 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 2.415232e-05 | 4.617 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 2.643635e-05 | 4.578 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 2.655930e-05 | 4.576 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 2.915666e-05 | 4.535 | 1 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 3.290976e-05 | 4.483 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 3.375820e-05 | 4.472 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 3.418073e-05 | 4.466 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 3.608044e-05 | 4.443 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 3.608044e-05 | 4.443 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 3.813136e-05 | 4.419 | 1 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 3.938001e-05 | 4.405 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 4.201886e-05 | 4.377 | 0 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 4.271353e-05 | 4.369 | 1 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 4.271353e-05 | 4.369 | 1 | 0 |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | R-HSA-9824878 | 4.289871e-05 | 4.368 | 1 | 1 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 4.318184e-05 | 4.365 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 6.228467e-05 | 4.206 | 0 | 0 |
| Signal Transduction | R-HSA-162582 | 6.560751e-05 | 4.183 | 1 | 0 |
| Influenza Infection | R-HSA-168255 | 6.865274e-05 | 4.163 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 6.887504e-05 | 4.162 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 6.887504e-05 | 4.162 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 6.978076e-05 | 4.156 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 7.828691e-05 | 4.106 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 8.339836e-05 | 4.079 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 8.565312e-05 | 4.067 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 8.565312e-05 | 4.067 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 8.514371e-05 | 4.070 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 9.342215e-05 | 4.030 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 9.803296e-05 | 4.009 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 9.924560e-05 | 4.003 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 1.012497e-04 | 3.995 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 1.012497e-04 | 3.995 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 1.164705e-04 | 3.934 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 1.112923e-04 | 3.954 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 1.087473e-04 | 3.964 | 0 | 0 |
| Josephin domain DUBs | R-HSA-5689877 | 1.208091e-04 | 3.918 | 0 | 0 |
| Apoptosis induced DNA fragmentation | R-HSA-140342 | 1.208091e-04 | 3.918 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 1.238382e-04 | 3.907 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 1.238382e-04 | 3.907 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 1.489622e-04 | 3.827 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 1.559144e-04 | 3.807 | 0 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 1.507187e-04 | 3.822 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 1.589088e-04 | 3.799 | 0 | 0 |
| Protein folding | R-HSA-391251 | 1.583103e-04 | 3.800 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 1.509834e-04 | 3.821 | 1 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 1.485632e-04 | 3.828 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 1.511639e-04 | 3.821 | 0 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 1.851518e-04 | 3.732 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 1.892010e-04 | 3.723 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 1.948405e-04 | 3.710 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 1.953813e-04 | 3.709 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 2.138218e-04 | 3.670 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 2.138218e-04 | 3.670 | 0 | 0 |
| Kinesins | R-HSA-983189 | 2.209273e-04 | 3.656 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 2.424698e-04 | 3.615 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 2.463789e-04 | 3.608 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 2.476168e-04 | 3.606 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 2.624737e-04 | 3.581 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 2.769839e-04 | 3.558 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 2.769839e-04 | 3.558 | 0 | 0 |
| FLT3 signaling by CBL mutants | R-HSA-9706377 | 3.194426e-04 | 3.496 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 3.111803e-04 | 3.507 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 3.111803e-04 | 3.507 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 3.080527e-04 | 3.511 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 3.079824e-04 | 3.511 | 1 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 3.427172e-04 | 3.465 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 3.431052e-04 | 3.465 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 3.669496e-04 | 3.435 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 3.669496e-04 | 3.435 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 3.786709e-04 | 3.422 | 1 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 3.933317e-04 | 3.405 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 4.123845e-04 | 3.385 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 4.188417e-04 | 3.378 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 4.225089e-04 | 3.374 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 4.800136e-04 | 3.319 | 0 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 4.800136e-04 | 3.319 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 5.209705e-04 | 3.283 | 1 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 5.372819e-04 | 3.270 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 5.896748e-04 | 3.229 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 6.226531e-04 | 3.206 | 1 | 1 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 5.896748e-04 | 3.229 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 5.726559e-04 | 3.242 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 6.464154e-04 | 3.189 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 6.480178e-04 | 3.188 | 1 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 7.194631e-04 | 3.143 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 7.407629e-04 | 3.130 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 7.410956e-04 | 3.130 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 7.425016e-04 | 3.129 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 8.307393e-04 | 3.081 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 8.369956e-04 | 3.077 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 8.721388e-04 | 3.059 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 9.130643e-04 | 3.039 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 9.546545e-04 | 3.020 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 9.724461e-04 | 3.012 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 1.014390e-03 | 2.994 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 1.023226e-03 | 2.990 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 1.037232e-03 | 2.984 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 1.131277e-03 | 2.946 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 1.131277e-03 | 2.946 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 1.131277e-03 | 2.946 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 1.131277e-03 | 2.946 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 1.185853e-03 | 2.926 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 1.108846e-03 | 2.955 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 1.137573e-03 | 2.944 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 1.129639e-03 | 2.947 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 1.109462e-03 | 2.955 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 1.131277e-03 | 2.946 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 1.218034e-03 | 2.914 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 1.236920e-03 | 2.908 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 1.256125e-03 | 2.901 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 1.258376e-03 | 2.900 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 1.258376e-03 | 2.900 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 1.316086e-03 | 2.881 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 1.323265e-03 | 2.878 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 1.436469e-03 | 2.843 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 1.498646e-03 | 2.824 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 1.498646e-03 | 2.824 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 1.499041e-03 | 2.824 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 1.511065e-03 | 2.821 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 1.545548e-03 | 2.811 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 1.548623e-03 | 2.810 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 1.609930e-03 | 2.793 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 1.902346e-03 | 2.721 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 1.939372e-03 | 2.712 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 1.712852e-03 | 2.766 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 1.961867e-03 | 2.707 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 1.860868e-03 | 2.730 | 0 | 0 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 1.983495e-03 | 2.703 | 1 | 1 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 2.019329e-03 | 2.695 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 2.052462e-03 | 2.688 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 2.052462e-03 | 2.688 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 2.052462e-03 | 2.688 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 2.052462e-03 | 2.688 | 1 | 1 |
| Signaling by RAS mutants | R-HSA-6802949 | 2.052462e-03 | 2.688 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 2.052462e-03 | 2.688 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 2.053434e-03 | 2.688 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 2.092062e-03 | 2.679 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 2.097464e-03 | 2.678 | 1 | 1 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 2.144199e-03 | 2.669 | 0 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 2.144199e-03 | 2.669 | 0 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 2.144199e-03 | 2.669 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 2.300339e-03 | 2.638 | 1 | 0 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | R-HSA-975144 | 2.305124e-03 | 2.637 | 0 | 0 |
| IRAK1 recruits IKK complex | R-HSA-937039 | 2.305124e-03 | 2.637 | 0 | 0 |
| VLDLR internalisation and degradation | R-HSA-8866427 | 2.305124e-03 | 2.637 | 0 | 0 |
| Myoclonic epilepsy of Lafora | R-HSA-3785653 | 2.343599e-03 | 2.630 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 2.343599e-03 | 2.630 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 2.343599e-03 | 2.630 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 2.850166e-03 | 2.545 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 2.802275e-03 | 2.552 | 0 | 0 |
| Carboxyterminal post-translational modifications of tubulin | R-HSA-8955332 | 2.378529e-03 | 2.624 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 2.702095e-03 | 2.568 | 0 | 0 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 2.702095e-03 | 2.568 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 2.745628e-03 | 2.561 | 0 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 2.756059e-03 | 2.560 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 2.821698e-03 | 2.549 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 2.446557e-03 | 2.611 | 1 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 2.630794e-03 | 2.580 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 2.702095e-03 | 2.568 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 2.384222e-03 | 2.623 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 2.453344e-03 | 2.610 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 2.863480e-03 | 2.543 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 2.871031e-03 | 2.542 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 2.940839e-03 | 2.532 | 1 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 2.965353e-03 | 2.528 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 2.970628e-03 | 2.527 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 2.970822e-03 | 2.527 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 3.017951e-03 | 2.520 | 1 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 3.019200e-03 | 2.520 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 3.098152e-03 | 2.509 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 3.264138e-03 | 2.486 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 3.275825e-03 | 2.485 | 1 | 1 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 3.327101e-03 | 2.478 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 3.327101e-03 | 2.478 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 3.374890e-03 | 2.472 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 3.388370e-03 | 2.470 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 3.388370e-03 | 2.470 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 3.502299e-03 | 2.456 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 3.559905e-03 | 2.449 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 4.586203e-03 | 2.339 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 4.586203e-03 | 2.339 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 4.586203e-03 | 2.339 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 4.586203e-03 | 2.339 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 4.586203e-03 | 2.339 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 4.586203e-03 | 2.339 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 4.586203e-03 | 2.339 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 4.586203e-03 | 2.339 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 4.586203e-03 | 2.339 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 4.586203e-03 | 2.339 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 4.586203e-03 | 2.339 | 0 | 0 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | 4.561059e-03 | 2.341 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 4.285947e-03 | 2.368 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 4.285947e-03 | 2.368 | 0 | 0 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | R-HSA-5684264 | 4.078801e-03 | 2.389 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 4.340867e-03 | 2.362 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 4.182683e-03 | 2.379 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 4.078801e-03 | 2.389 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 4.118367e-03 | 2.385 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 3.998772e-03 | 2.398 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 3.793221e-03 | 2.421 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 4.103065e-03 | 2.387 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 3.793221e-03 | 2.421 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 3.998772e-03 | 2.398 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 4.670796e-03 | 2.331 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 4.291364e-03 | 2.367 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 4.118367e-03 | 2.385 | 0 | 0 |
| Maturation of protein E | R-HSA-9683683 | 4.561059e-03 | 2.341 | 0 | 0 |
| Maturation of protein E | R-HSA-9694493 | 4.561059e-03 | 2.341 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 4.700617e-03 | 2.328 | 1 | 1 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 4.731865e-03 | 2.325 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 4.731865e-03 | 2.325 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 4.731865e-03 | 2.325 | 0 | 0 |
| Pexophagy | R-HSA-9664873 | 4.731865e-03 | 2.325 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 4.831128e-03 | 2.316 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 4.985827e-03 | 2.302 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 5.088230e-03 | 2.293 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 5.088230e-03 | 2.293 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 5.095789e-03 | 2.293 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 5.271835e-03 | 2.278 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 5.331474e-03 | 2.273 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 5.430646e-03 | 2.265 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 5.589210e-03 | 2.253 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 5.901267e-03 | 2.229 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 6.050028e-03 | 2.218 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 6.258824e-03 | 2.204 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 6.281813e-03 | 2.202 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 6.702208e-03 | 2.174 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 7.182574e-03 | 2.144 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 7.434132e-03 | 2.129 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 7.608873e-03 | 2.119 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 7.635675e-03 | 2.117 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 8.129776e-03 | 2.090 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 8.129776e-03 | 2.090 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 8.174919e-03 | 2.088 | 0 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 8.174919e-03 | 2.088 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 8.211820e-03 | 2.086 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 8.223834e-03 | 2.085 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 8.223834e-03 | 2.085 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 8.499420e-03 | 2.071 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 8.811108e-03 | 2.055 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 8.811108e-03 | 2.055 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 9.078482e-03 | 2.042 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 9.162676e-03 | 2.038 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 9.162676e-03 | 2.038 | 0 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 9.162676e-03 | 2.038 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 9.804307e-03 | 2.009 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 9.804307e-03 | 2.009 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 1.000160e-02 | 2.000 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 1.000160e-02 | 2.000 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 1.000160e-02 | 2.000 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 1.014879e-02 | 1.994 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 1.014879e-02 | 1.994 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 1.021771e-02 | 1.991 | 0 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 1.021771e-02 | 1.991 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 1.045609e-02 | 1.981 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 1.062754e-02 | 1.974 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 1.069874e-02 | 1.971 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 1.076614e-02 | 1.968 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 1.143003e-02 | 1.942 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 1.147367e-02 | 1.940 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 1.171264e-02 | 1.931 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 1.184551e-02 | 1.926 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 1.189200e-02 | 1.925 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 1.194038e-02 | 1.923 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 1.203208e-02 | 1.920 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 1.203208e-02 | 1.920 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 1.203208e-02 | 1.920 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 1.203208e-02 | 1.920 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 1.203208e-02 | 1.920 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 1.205467e-02 | 1.919 | 0 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 1.247841e-02 | 1.904 | 1 | 1 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 1.247841e-02 | 1.904 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 1.266297e-02 | 1.897 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 1.284219e-02 | 1.891 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 1.294773e-02 | 1.888 | 0 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 1.294773e-02 | 1.888 | 0 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 1.372782e-02 | 1.862 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 1.390472e-02 | 1.857 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 1.528485e-02 | 1.816 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 1.346130e-02 | 1.871 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 1.391611e-02 | 1.856 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 1.388034e-02 | 1.858 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 1.706451e-02 | 1.768 | 0 | 0 |
| Translesion Synthesis by POLH | R-HSA-110320 | 1.528485e-02 | 1.816 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 1.508250e-02 | 1.822 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 1.733225e-02 | 1.761 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 1.726167e-02 | 1.763 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 1.763764e-02 | 1.754 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 1.673864e-02 | 1.776 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 1.764516e-02 | 1.753 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 1.532514e-02 | 1.815 | 0 | 0 |
| Modulation by Mtb of host immune system | R-HSA-9637628 | 1.347328e-02 | 1.871 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex | R-HSA-937042 | 1.791439e-02 | 1.747 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 1.791439e-02 | 1.747 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 1.842989e-02 | 1.734 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 1.842989e-02 | 1.734 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 1.869229e-02 | 1.728 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 1.877438e-02 | 1.726 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 1.884862e-02 | 1.725 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 1.891058e-02 | 1.723 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 1.923016e-02 | 1.716 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 1.954744e-02 | 1.709 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 2.037756e-02 | 1.691 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 2.053776e-02 | 1.687 | 0 | 0 |
| IRS activation | R-HSA-74713 | 2.053776e-02 | 1.687 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 2.055686e-02 | 1.687 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 2.055686e-02 | 1.687 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 2.055686e-02 | 1.687 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 2.127682e-02 | 1.672 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 2.127682e-02 | 1.672 | 1 | 1 |
| Translesion synthesis by REV1 | R-HSA-110312 | 2.127682e-02 | 1.672 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 2.127682e-02 | 1.672 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 2.150187e-02 | 1.668 | 0 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 2.153441e-02 | 1.667 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 2.158808e-02 | 1.666 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 2.175962e-02 | 1.662 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 2.199089e-02 | 1.658 | 0 | 0 |
| Folding of actin by CCT/TriC | R-HSA-390450 | 2.316937e-02 | 1.635 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 2.378662e-02 | 1.624 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 2.391625e-02 | 1.621 | 1 | 1 |
| Ca-dependent events | R-HSA-111996 | 2.414662e-02 | 1.617 | 0 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 2.432032e-02 | 1.614 | 0 | 0 |
| Manipulation of host energy metabolism | R-HSA-9636667 | 2.565960e-02 | 1.591 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 2.565960e-02 | 1.591 | 0 | 0 |
| Translesion synthesis by POLI | R-HSA-5656121 | 2.576365e-02 | 1.589 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 2.591781e-02 | 1.586 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 2.596893e-02 | 1.586 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 2.708735e-02 | 1.567 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 2.741881e-02 | 1.562 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 2.741881e-02 | 1.562 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 2.741881e-02 | 1.562 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 2.782523e-02 | 1.556 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 2.857862e-02 | 1.544 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 2.889071e-02 | 1.539 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 2.889071e-02 | 1.539 | 0 | 0 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | 2.926898e-02 | 1.534 | 0 | 0 |
| Alpha-protein kinase 1 signaling pathway | R-HSA-9645460 | 2.926898e-02 | 1.534 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 2.950112e-02 | 1.530 | 0 | 0 |
| MAP kinase activation | R-HSA-450294 | 2.955629e-02 | 1.529 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 2.955629e-02 | 1.529 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 3.001950e-02 | 1.523 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 3.031407e-02 | 1.518 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 3.032601e-02 | 1.518 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 3.046911e-02 | 1.516 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 3.076369e-02 | 1.512 | 0 | 0 |
| Translesion synthesis by POLK | R-HSA-5655862 | 3.081388e-02 | 1.511 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 3.081388e-02 | 1.511 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 3.082844e-02 | 1.511 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 3.082844e-02 | 1.511 | 1 | 1 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 3.142779e-02 | 1.503 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 3.142779e-02 | 1.503 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 3.159510e-02 | 1.500 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 3.225811e-02 | 1.491 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 3.250258e-02 | 1.488 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 3.250258e-02 | 1.488 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 3.257131e-02 | 1.487 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 3.257131e-02 | 1.487 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 3.310402e-02 | 1.480 | 0 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 3.407258e-02 | 1.468 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 3.447116e-02 | 1.463 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 3.490142e-02 | 1.457 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 3.623323e-02 | 1.441 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 3.623323e-02 | 1.441 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperone genes | R-HSA-381183 | 3.623323e-02 | 1.441 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 3.644434e-02 | 1.438 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 3.644434e-02 | 1.438 | 0 | 0 |
| Glycogen storage diseases | R-HSA-3229121 | 3.644434e-02 | 1.438 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 3.654103e-02 | 1.437 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 3.654103e-02 | 1.437 | 0 | 0 |
| S Phase | R-HSA-69242 | 3.656688e-02 | 1.437 | 0 | 0 |
| Regulation of TP53 Expression | R-HSA-6804754 | 4.325335e-02 | 1.364 | 0 | 0 |
| Activation, myristolyation of BID and translocation to mitochondria | R-HSA-75108 | 4.325335e-02 | 1.364 | 0 | 0 |
| Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) | R-HSA-1299308 | 4.325335e-02 | 1.364 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 5.015414e-02 | 1.300 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 4.407190e-02 | 1.356 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 4.407190e-02 | 1.356 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 4.266758e-02 | 1.370 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 4.266758e-02 | 1.370 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 4.949185e-02 | 1.305 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 5.468275e-02 | 1.262 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 4.869090e-02 | 1.313 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 4.989254e-02 | 1.302 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 4.989254e-02 | 1.302 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 5.281789e-02 | 1.277 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 4.767965e-02 | 1.322 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 4.394666e-02 | 1.357 | 0 | 0 |
| Meiosis | R-HSA-1500620 | 4.662560e-02 | 1.331 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 5.042858e-02 | 1.297 | 0 | 0 |
| Membrane binding and targetting of GAG proteins | R-HSA-174490 | 5.278515e-02 | 1.277 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 4.829258e-02 | 1.316 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 4.829258e-02 | 1.316 | 0 | 0 |
| Translation | R-HSA-72766 | 4.195831e-02 | 1.377 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 4.920023e-02 | 1.308 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 4.244513e-02 | 1.372 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 5.468275e-02 | 1.262 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 5.167391e-02 | 1.287 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 5.167391e-02 | 1.287 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 4.148299e-02 | 1.382 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 5.468275e-02 | 1.262 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 4.784208e-02 | 1.320 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 5.042858e-02 | 1.297 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 4.691152e-02 | 1.329 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 4.949185e-02 | 1.305 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 4.949185e-02 | 1.305 | 1 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 5.167391e-02 | 1.287 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 5.354431e-02 | 1.271 | 0 | 0 |
| Uptake and function of diphtheria toxin | R-HSA-5336415 | 5.015414e-02 | 1.300 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 4.973367e-02 | 1.303 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | R-HSA-2691232 | 4.407190e-02 | 1.356 | 0 | 0 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | R-HSA-2691230 | 4.407190e-02 | 1.356 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 3.907816e-02 | 1.408 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 3.907816e-02 | 1.408 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 4.407975e-02 | 1.356 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 4.269966e-02 | 1.370 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 5.498529e-02 | 1.260 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 4.412992e-02 | 1.355 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 4.677731e-02 | 1.330 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperones | R-HSA-381033 | 5.278515e-02 | 1.277 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 4.590585e-02 | 1.338 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 4.116210e-02 | 1.386 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 4.691152e-02 | 1.329 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 5.619081e-02 | 1.250 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 5.623253e-02 | 1.250 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 5.673681e-02 | 1.246 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 5.692114e-02 | 1.245 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 5.709048e-02 | 1.243 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 5.986105e-02 | 1.223 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 6.037198e-02 | 1.219 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 6.053143e-02 | 1.218 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 6.053143e-02 | 1.218 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 6.162515e-02 | 1.210 | 0 | 0 |
| Response of Mtb to phagocytosis | R-HSA-9637690 | 6.210380e-02 | 1.207 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 6.230556e-02 | 1.205 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 6.230556e-02 | 1.205 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 6.236428e-02 | 1.205 | 0 | 0 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | R-HSA-174495 | 6.236428e-02 | 1.205 | 0 | 0 |
| Formyl peptide receptors bind formyl peptides and many other ligands | R-HSA-444473 | 6.296179e-02 | 1.201 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 6.296179e-02 | 1.201 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 6.363742e-02 | 1.196 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 6.410608e-02 | 1.193 | 0 | 0 |
| Axonal growth stimulation | R-HSA-209563 | 6.410608e-02 | 1.193 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 6.475251e-02 | 1.189 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 6.475251e-02 | 1.189 | 0 | 0 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 6.495530e-02 | 1.187 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 6.495530e-02 | 1.187 | 0 | 0 |
| Prevention of phagosomal-lysosomal fusion | R-HSA-9636383 | 6.495530e-02 | 1.187 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 6.571564e-02 | 1.182 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 6.638655e-02 | 1.178 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 6.749567e-02 | 1.171 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 6.749567e-02 | 1.171 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 6.825712e-02 | 1.166 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 6.841958e-02 | 1.165 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 6.933445e-02 | 1.159 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 7.022253e-02 | 1.154 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 7.088114e-02 | 1.149 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 7.137672e-02 | 1.146 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 7.137672e-02 | 1.146 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 7.137672e-02 | 1.146 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 7.279255e-02 | 1.138 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 7.279255e-02 | 1.138 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 7.294906e-02 | 1.137 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 7.359028e-02 | 1.133 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 7.359028e-02 | 1.133 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 7.359028e-02 | 1.133 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 7.359028e-02 | 1.133 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 7.375971e-02 | 1.132 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 7.375971e-02 | 1.132 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 7.375971e-02 | 1.132 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 7.411946e-02 | 1.130 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 7.453931e-02 | 1.128 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 7.568666e-02 | 1.121 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 7.711858e-02 | 1.113 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 7.711858e-02 | 1.113 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 7.711858e-02 | 1.113 | 0 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 7.711858e-02 | 1.113 | 0 | 0 |
| APC truncation mutants are not K63 polyubiquitinated | R-HSA-5467333 | 7.864765e-02 | 1.104 | 0 | 0 |
| Loss of function of TP53 in cancer due to loss of tetramerization ability | R-HSA-9723905 | 7.864765e-02 | 1.104 | 0 | 0 |
| Loss of Function of TP53 in Cancer | R-HSA-9723907 | 7.864765e-02 | 1.104 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 7.866697e-02 | 1.104 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 7.866697e-02 | 1.104 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 7.871009e-02 | 1.104 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 7.910880e-02 | 1.102 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 7.910880e-02 | 1.102 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 8.005104e-02 | 1.097 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 8.281821e-02 | 1.082 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 8.404602e-02 | 1.075 | 0 | 0 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 8.404602e-02 | 1.075 | 0 | 0 |
| Regulation of BACH1 activity | R-HSA-9708530 | 8.404602e-02 | 1.075 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 8.464991e-02 | 1.072 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 8.464991e-02 | 1.072 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 8.665133e-02 | 1.062 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 8.680930e-02 | 1.061 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 8.680930e-02 | 1.061 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 8.759715e-02 | 1.058 | 0 | 0 |
| TLR3-mediated TICAM1-dependent programmed cell death | R-HSA-9013957 | 8.759715e-02 | 1.058 | 0 | 0 |
| NADE modulates death signalling | R-HSA-205025 | 8.759715e-02 | 1.058 | 0 | 0 |
| RUNX2 regulates genes involved in differentiation of myeloid cells | R-HSA-8941333 | 8.759715e-02 | 1.058 | 0 | 0 |
| MTF1 activates gene expression | R-HSA-5660489 | 8.759715e-02 | 1.058 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 8.759715e-02 | 1.058 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 8.762134e-02 | 1.057 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 8.762134e-02 | 1.057 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 8.841749e-02 | 1.053 | 0 | 0 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | R-HSA-5140745 | 9.253094e-02 | 1.034 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 9.253094e-02 | 1.034 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 9.253094e-02 | 1.034 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 9.253094e-02 | 1.034 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 9.262775e-02 | 1.033 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 9.482044e-02 | 1.023 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 9.487271e-02 | 1.023 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 9.531375e-02 | 1.021 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 9.531375e-02 | 1.021 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 9.531375e-02 | 1.021 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 9.545037e-02 | 1.020 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 9.609444e-02 | 1.017 | 0 | 0 |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | R-HSA-975110 | 9.609444e-02 | 1.017 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 9.669573e-02 | 1.015 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 9.776684e-02 | 1.010 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 9.979342e-02 | 1.001 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 1.002993e-01 | 0.999 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 1.007732e-01 | 0.997 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 1.016452e-01 | 0.993 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 1.030042e-01 | 0.987 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 1.030042e-01 | 0.987 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 1.033678e-01 | 0.986 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 1.033678e-01 | 0.986 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 1.033678e-01 | 0.986 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 1.033678e-01 | 0.986 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 1.045331e-01 | 0.981 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 1.045331e-01 | 0.981 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 1.070381e-01 | 0.970 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 1.089021e-01 | 0.963 | 0 | 0 |
| Regulation of FZD by ubiquitination | R-HSA-4641263 | 1.089021e-01 | 0.963 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 1.090962e-01 | 0.962 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 1.117782e-01 | 0.952 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 1.127743e-01 | 0.948 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 1.127743e-01 | 0.948 | 0 | 0 |
| IRF3 mediated activation of type 1 IFN | R-HSA-1606341 | 1.131832e-01 | 0.946 | 1 | 1 |
| RUNX2 regulates chondrocyte maturation | R-HSA-8941284 | 1.131832e-01 | 0.946 | 0 | 0 |
| Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 1.131832e-01 | 0.946 | 0 | 0 |
| Nectin/Necl trans heterodimerization | R-HSA-420597 | 1.131832e-01 | 0.946 | 0 | 0 |
| Resolution of AP sites via the single-nucleotide replacement pathway | R-HSA-110381 | 1.131832e-01 | 0.946 | 0 | 0 |
| Pyrophosphate hydrolysis | R-HSA-71737 | 1.131832e-01 | 0.946 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 1.131832e-01 | 0.946 | 0 | 0 |
| Regulation of PAK-2p34 activity by PS-GAP/RHG10 | R-HSA-211728 | 1.511142e-01 | 0.821 | 0 | 0 |
| SARS-CoV-1 targets PDZ proteins in cell-cell junction | R-HSA-9692912 | 1.511142e-01 | 0.821 | 0 | 0 |
| TICAM1 deficiency - HSE | R-HSA-5602566 | 1.511142e-01 | 0.821 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH6 | R-HSA-5632968 | 1.511142e-01 | 0.821 | 0 | 0 |
| Interactions of Tat with host cellular proteins | R-HSA-176034 | 2.178850e-01 | 0.662 | 0 | 0 |
| NFG and proNGF binds to p75NTR | R-HSA-205017 | 2.178850e-01 | 0.662 | 0 | 0 |
| TRAF3 deficiency - HSE | R-HSA-5602571 | 2.178850e-01 | 0.662 | 0 | 0 |
| Signaling by TCF7L2 mutants | R-HSA-5339700 | 2.178850e-01 | 0.662 | 0 | 0 |
| Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) | R-HSA-5619039 | 2.178850e-01 | 0.662 | 0 | 0 |
| SMAD2/3 MH2 Domain Mutants in Cancer | R-HSA-3315487 | 2.178850e-01 | 0.662 | 0 | 0 |
| Defective SLC6A2 causes orthostatic intolerance (OI) | R-HSA-5619109 | 2.178850e-01 | 0.662 | 0 | 0 |
| SMAD4 MH2 Domain Mutants in Cancer | R-HSA-3311021 | 2.178850e-01 | 0.662 | 0 | 0 |
| IKBKB deficiency causes SCID | R-HSA-5602636 | 2.178850e-01 | 0.662 | 0 | 0 |
| Loss of Function of SMAD4 in Cancer | R-HSA-3304347 | 2.178850e-01 | 0.662 | 0 | 0 |
| Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | R-HSA-5619111 | 2.178850e-01 | 0.662 | 0 | 0 |
| IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | R-HSA-5603027 | 2.178850e-01 | 0.662 | 0 | 0 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 1.403901e-01 | 0.853 | 0 | 0 |
| Noncanonical activation of NOTCH3 | R-HSA-9017802 | 1.403901e-01 | 0.853 | 0 | 0 |
| RUNX3 regulates YAP1-mediated transcription | R-HSA-8951671 | 1.688049e-01 | 0.773 | 0 | 0 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | 1.980698e-01 | 0.703 | 0 | 0 |
| Binding of TCF/LEF:CTNNB1 to target gene promoters | R-HSA-4411364 | 1.980698e-01 | 0.703 | 0 | 0 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 1.980698e-01 | 0.703 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 1.980698e-01 | 0.703 | 0 | 0 |
| Recycling of eIF2:GDP | R-HSA-72731 | 1.980698e-01 | 0.703 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 1.980698e-01 | 0.703 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 1.646090e-01 | 0.784 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | R-HSA-9029558 | 1.646090e-01 | 0.784 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 1.646090e-01 | 0.784 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 1.224286e-01 | 0.912 | 0 | 0 |
| Retrograde neurotrophin signalling | R-HSA-177504 | 1.846777e-01 | 0.734 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 1.253849e-01 | 0.902 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 1.668648e-01 | 0.778 | 1 | 1 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 1.373460e-01 | 0.862 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 1.373460e-01 | 0.862 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 2.265012e-01 | 0.645 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 1.827978e-01 | 0.738 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 1.497884e-01 | 0.825 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 1.497884e-01 | 0.825 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 1.626853e-01 | 0.789 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 1.992050e-01 | 0.701 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 1.760084e-01 | 0.754 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE | R-HSA-77075 | 2.160335e-01 | 0.665 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | R-HSA-167160 | 2.160335e-01 | 0.665 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 1.242142e-01 | 0.906 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 1.326119e-01 | 0.877 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 1.794640e-01 | 0.746 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 1.916014e-01 | 0.718 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 1.916014e-01 | 0.718 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 1.916014e-01 | 0.718 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 1.916014e-01 | 0.718 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 1.799265e-01 | 0.745 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 2.167628e-01 | 0.664 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 2.167628e-01 | 0.664 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 2.167628e-01 | 0.664 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 1.763979e-01 | 0.754 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 1.734839e-01 | 0.761 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 1.624153e-01 | 0.789 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 1.492836e-01 | 0.826 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 2.182344e-01 | 0.661 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 2.040413e-01 | 0.690 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 1.760084e-01 | 0.754 | 0 | 0 |
| Nef Mediated CD4 Down-regulation | R-HSA-167590 | 1.980698e-01 | 0.703 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 1.992050e-01 | 0.701 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 2.020475e-01 | 0.695 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 1.488315e-01 | 0.827 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 1.450625e-01 | 0.838 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 2.265886e-01 | 0.645 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 1.450625e-01 | 0.838 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 2.160335e-01 | 0.665 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 1.897282e-01 | 0.722 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 1.242142e-01 | 0.906 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 1.906902e-01 | 0.720 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 1.862206e-01 | 0.730 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 1.688049e-01 | 0.773 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 1.139301e-01 | 0.943 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 2.045374e-01 | 0.689 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 1.689476e-01 | 0.772 | 0 | 0 |
| Activation and oligomerization of BAK protein | R-HSA-111452 | 1.511142e-01 | 0.821 | 0 | 0 |
| Oligomerization of connexins into connexons | R-HSA-190704 | 2.178850e-01 | 0.662 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 1.343264e-01 | 0.872 | 0 | 0 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 1.692699e-01 | 0.771 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 2.167628e-01 | 0.664 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 2.134833e-01 | 0.671 | 0 | 0 |
| Response of EIF2AK1 (HRI) to heme deficiency | R-HSA-9648895 | 2.160335e-01 | 0.665 | 0 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 1.316848e-01 | 0.880 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 2.105451e-01 | 0.677 | 0 | 0 |
| PKA-mediated phosphorylation of key metabolic factors | R-HSA-163358 | 1.403901e-01 | 0.853 | 0 | 0 |
| Aryl hydrocarbon receptor signalling | R-HSA-8937144 | 1.403901e-01 | 0.853 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 2.038140e-01 | 0.691 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 1.133567e-01 | 0.946 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 1.514583e-01 | 0.820 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 1.296397e-01 | 0.887 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 1.283161e-01 | 0.892 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 2.182344e-01 | 0.661 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 1.586914e-01 | 0.799 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 1.242157e-01 | 0.906 | 0 | 0 |
| Activation, translocation and oligomerization of BAX | R-HSA-114294 | 1.511142e-01 | 0.821 | 0 | 0 |
| Inhibition of PKR | R-HSA-169131 | 1.511142e-01 | 0.821 | 0 | 0 |
| ARL13B-mediated ciliary trafficking of INPP5E | R-HSA-5624958 | 2.178850e-01 | 0.662 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH2 | R-HSA-5632928 | 2.178850e-01 | 0.662 | 0 | 0 |
| Transport of connexins along the secretory pathway | R-HSA-190827 | 2.178850e-01 | 0.662 | 0 | 0 |
| Cation-coupled Chloride cotransporters | R-HSA-426117 | 1.980698e-01 | 0.703 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 1.239833e-01 | 0.907 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 1.450625e-01 | 0.838 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 1.561758e-01 | 0.806 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 1.561758e-01 | 0.806 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 1.488315e-01 | 0.827 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 2.086180e-01 | 0.681 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 1.139301e-01 | 0.943 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 1.453041e-01 | 0.838 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 1.794640e-01 | 0.746 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 2.182344e-01 | 0.661 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 1.242142e-01 | 0.906 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 1.140479e-01 | 0.943 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 1.239833e-01 | 0.907 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 1.161049e-01 | 0.935 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 1.781125e-01 | 0.749 | 0 | 0 |
| PLC beta mediated events | R-HSA-112043 | 1.185111e-01 | 0.926 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 1.183243e-01 | 0.927 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 1.296397e-01 | 0.887 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 1.497884e-01 | 0.825 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 1.626853e-01 | 0.789 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 2.182344e-01 | 0.661 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 1.488315e-01 | 0.827 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 2.234309e-01 | 0.651 | 0 | 0 |
| Immune System | R-HSA-168256 | 1.268789e-01 | 0.897 | 1 | 0 |
| RUNX1 regulates expression of components of tight junctions | R-HSA-8935964 | 1.403901e-01 | 0.853 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 2.182344e-01 | 0.661 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 1.944951e-01 | 0.711 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 1.474405e-01 | 0.831 | 0 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 1.846777e-01 | 0.734 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 1.674342e-01 | 0.776 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 1.497884e-01 | 0.825 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 2.182344e-01 | 0.661 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 1.205381e-01 | 0.919 | 0 | 0 |
| Sodium-coupled phosphate cotransporters | R-HSA-427652 | 1.403901e-01 | 0.853 | 0 | 0 |
| Assembly Of The HIV Virion | R-HSA-175474 | 1.827978e-01 | 0.738 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 2.160335e-01 | 0.665 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 1.369823e-01 | 0.863 | 1 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 1.373460e-01 | 0.862 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 1.811673e-01 | 0.742 | 0 | 0 |
| RUNX3 Regulates Immune Response and Cell Migration | R-HSA-8949275 | 1.980698e-01 | 0.703 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 1.224286e-01 | 0.912 | 0 | 0 |
| Suppression of phagosomal maturation | R-HSA-9637687 | 1.253849e-01 | 0.902 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 1.474405e-01 | 0.831 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 1.464000e-01 | 0.834 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 1.819936e-01 | 0.740 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 1.550504e-01 | 0.810 | 0 | 0 |
| PD-L1(CD274) glycosylation and translocation to plasma membrane | R-HSA-9931295 | 1.668648e-01 | 0.778 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 1.624153e-01 | 0.789 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 2.115219e-01 | 0.675 | 0 | 0 |
| Inactivation of CSF3 (G-CSF) signaling | R-HSA-9705462 | 1.827978e-01 | 0.738 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 1.827978e-01 | 0.738 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 2.277447e-01 | 0.643 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 2.278757e-01 | 0.642 | 0 | 0 |
| EGFR interacts with phospholipase C-gamma | R-HSA-212718 | 2.278757e-01 | 0.642 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 2.278757e-01 | 0.642 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 2.278757e-01 | 0.642 | 0 | 0 |
| Axonal growth inhibition (RHOA activation) | R-HSA-193634 | 2.278757e-01 | 0.642 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 2.278757e-01 | 0.642 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | R-HSA-8939246 | 2.278757e-01 | 0.642 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 2.343739e-01 | 0.630 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 2.429650e-01 | 0.614 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 2.464143e-01 | 0.608 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 2.469321e-01 | 0.607 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 2.479510e-01 | 0.606 | 0 | 0 |
| Calnexin/calreticulin cycle | R-HSA-901042 | 2.479510e-01 | 0.606 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 2.479510e-01 | 0.606 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 2.479510e-01 | 0.606 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 2.480473e-01 | 0.605 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 2.480473e-01 | 0.605 | 0 | 0 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 2.480473e-01 | 0.605 | 1 | 1 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 2.480473e-01 | 0.605 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 2.480473e-01 | 0.605 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 2.507431e-01 | 0.601 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 2.507431e-01 | 0.601 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 2.507431e-01 | 0.601 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 2.523794e-01 | 0.598 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 2.550858e-01 | 0.593 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 2.558137e-01 | 0.592 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 2.564020e-01 | 0.591 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 2.564020e-01 | 0.591 | 0 | 0 |
| G1 Phase | R-HSA-69236 | 2.564020e-01 | 0.591 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 2.564020e-01 | 0.591 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 2.579566e-01 | 0.588 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 2.579566e-01 | 0.588 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 2.579566e-01 | 0.588 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 2.579566e-01 | 0.588 | 0 | 0 |
| 5-Phosphoribose 1-diphosphate biosynthesis | R-HSA-73843 | 2.579566e-01 | 0.588 | 0 | 0 |
| p75NTR regulates axonogenesis | R-HSA-193697 | 2.579566e-01 | 0.588 | 0 | 0 |
| APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway | R-HSA-5649702 | 2.579566e-01 | 0.588 | 0 | 0 |
| Unwinding of DNA | R-HSA-176974 | 2.579566e-01 | 0.588 | 0 | 0 |
| Inactivation of CDC42 and RAC1 | R-HSA-428543 | 2.579566e-01 | 0.588 | 0 | 0 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | R-HSA-9013700 | 2.579566e-01 | 0.588 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 2.579566e-01 | 0.588 | 0 | 0 |
| Interleukin-1 processing | R-HSA-448706 | 2.579566e-01 | 0.588 | 0 | 0 |
| Respiratory syncytial virus genome replication | R-HSA-9834752 | 2.579566e-01 | 0.588 | 0 | 0 |
| Butyrophilin (BTN) family interactions | R-HSA-8851680 | 2.579566e-01 | 0.588 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 2.613698e-01 | 0.583 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 2.631827e-01 | 0.580 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 2.685198e-01 | 0.571 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 2.698848e-01 | 0.569 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 2.698848e-01 | 0.569 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 2.700333e-01 | 0.569 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 2.700333e-01 | 0.569 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 2.700333e-01 | 0.569 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 2.700333e-01 | 0.569 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 2.700333e-01 | 0.569 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 2.737971e-01 | 0.563 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 2.737971e-01 | 0.563 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 2.743630e-01 | 0.562 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 2.751690e-01 | 0.560 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 2.763630e-01 | 0.559 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 2.779088e-01 | 0.556 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 2.786204e-01 | 0.555 | 0 | 0 |
| Stimulation of the cell death response by PAK-2p34 | R-HSA-211736 | 2.794075e-01 | 0.554 | 0 | 0 |
| Signalling to ERK5 | R-HSA-198765 | 2.794075e-01 | 0.554 | 0 | 0 |
| Glycogen storage disease type XV (GYG1) | R-HSA-3814836 | 2.794075e-01 | 0.554 | 0 | 0 |
| TGFBR1 LBD Mutants in Cancer | R-HSA-3656535 | 2.794075e-01 | 0.554 | 0 | 0 |
| Glycogen storage disease type 0 (muscle GYS1) | R-HSA-3828062 | 2.794075e-01 | 0.554 | 0 | 0 |
| Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | R-HSA-5619089 | 2.794075e-01 | 0.554 | 0 | 0 |
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | R-HSA-446343 | 2.794075e-01 | 0.554 | 0 | 0 |
| Neurophilin interactions with VEGF and VEGFR | R-HSA-194306 | 2.794075e-01 | 0.554 | 0 | 0 |
| tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | R-HSA-9708296 | 2.794075e-01 | 0.554 | 0 | 0 |
| Regulation of pyruvate metabolism | R-HSA-9861718 | 2.838365e-01 | 0.547 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 2.842232e-01 | 0.546 | 0 | 0 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 2.865101e-01 | 0.543 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 2.865101e-01 | 0.543 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 2.865101e-01 | 0.543 | 0 | 0 |
| ER Quality Control Compartment (ERQC) | R-HSA-901032 | 2.865101e-01 | 0.543 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 2.879874e-01 | 0.541 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 2.880851e-01 | 0.540 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 2.880851e-01 | 0.540 | 0 | 0 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | 2.880851e-01 | 0.540 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 2.880851e-01 | 0.540 | 0 | 0 |
| Assembly and release of respiratory syncytial virus (RSV) virions | R-HSA-9820962 | 2.880851e-01 | 0.540 | 0 | 0 |
| Tandem pore domain potassium channels | R-HSA-1296346 | 2.880851e-01 | 0.540 | 0 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 2.880851e-01 | 0.540 | 0 | 0 |
| PKA activation | R-HSA-163615 | 2.919220e-01 | 0.535 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 2.925380e-01 | 0.534 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 2.992694e-01 | 0.524 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 2.997078e-01 | 0.523 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 3.046647e-01 | 0.516 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 3.046647e-01 | 0.516 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 3.046647e-01 | 0.516 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 3.091598e-01 | 0.510 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 3.099865e-01 | 0.509 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 3.140728e-01 | 0.503 | 0 | 0 |
| Germ layer formation at gastrulation | R-HSA-9754189 | 3.140728e-01 | 0.503 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 3.140728e-01 | 0.503 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 3.140728e-01 | 0.503 | 0 | 0 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 3.180679e-01 | 0.497 | 0 | 0 |
| vRNP Assembly | R-HSA-192905 | 3.180679e-01 | 0.497 | 0 | 0 |
| ChREBP activates metabolic gene expression | R-HSA-163765 | 3.180679e-01 | 0.497 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 3.228022e-01 | 0.491 | 0 | 0 |
| mRNA Capping | R-HSA-72086 | 3.229361e-01 | 0.491 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 3.229361e-01 | 0.491 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 3.229361e-01 | 0.491 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 3.229361e-01 | 0.491 | 0 | 0 |
| RAS processing | R-HSA-9648002 | 3.258525e-01 | 0.487 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 3.260557e-01 | 0.487 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 3.260557e-01 | 0.487 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 3.264419e-01 | 0.486 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 3.279988e-01 | 0.484 | 0 | 0 |
| Activated NTRK3 signals through PLCG1 | R-HSA-9034793 | 3.360939e-01 | 0.474 | 0 | 0 |
| PLC-gamma1 signalling | R-HSA-167021 | 3.360939e-01 | 0.474 | 0 | 0 |
| MET activates PTPN11 | R-HSA-8865999 | 3.360939e-01 | 0.474 | 0 | 0 |
| STAT6-mediated induction of chemokines | R-HSA-3249367 | 3.360939e-01 | 0.474 | 1 | 1 |
| MET interacts with TNS proteins | R-HSA-8875513 | 3.360939e-01 | 0.474 | 0 | 0 |
| Diseases of Mismatch Repair (MMR) | R-HSA-5423599 | 3.360939e-01 | 0.474 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 3.362570e-01 | 0.473 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 3.362570e-01 | 0.473 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 3.362570e-01 | 0.473 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 3.362570e-01 | 0.473 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 3.412786e-01 | 0.467 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 3.412786e-01 | 0.467 | 0 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 3.412961e-01 | 0.467 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 3.418001e-01 | 0.466 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 3.418001e-01 | 0.466 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 3.418001e-01 | 0.466 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 3.477415e-01 | 0.459 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 3.584008e-01 | 0.446 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 3.584008e-01 | 0.446 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 3.590389e-01 | 0.445 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 3.640450e-01 | 0.439 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 3.705362e-01 | 0.431 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 3.712207e-01 | 0.430 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 3.720114e-01 | 0.429 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 3.738239e-01 | 0.427 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 3.769693e-01 | 0.424 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 3.769693e-01 | 0.424 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 3.769693e-01 | 0.424 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 3.769693e-01 | 0.424 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 3.769693e-01 | 0.424 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 3.769693e-01 | 0.424 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 3.769693e-01 | 0.424 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 3.769693e-01 | 0.424 | 0 | 0 |
| Advanced glycosylation endproduct receptor signaling | R-HSA-879415 | 3.769693e-01 | 0.424 | 0 | 0 |
| Signaling by LTK | R-HSA-9842663 | 3.769693e-01 | 0.424 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 3.769693e-01 | 0.424 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 3.772066e-01 | 0.423 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 3.780047e-01 | 0.423 | 0 | 0 |
| Mitochondrial calcium ion transport | R-HSA-8949215 | 3.804360e-01 | 0.420 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 3.834331e-01 | 0.416 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 3.844156e-01 | 0.415 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 3.867217e-01 | 0.413 | 0 | 0 |
| HCN channels | R-HSA-1296061 | 3.883242e-01 | 0.411 | 0 | 0 |
| Activated NTRK2 signals through PLCG1 | R-HSA-9026527 | 3.883242e-01 | 0.411 | 0 | 0 |
| Inhibition of TSC complex formation by PKB | R-HSA-165181 | 3.883242e-01 | 0.411 | 0 | 0 |
| GRB7 events in ERBB2 signaling | R-HSA-1306955 | 3.883242e-01 | 0.411 | 0 | 0 |
| TGFBR1 KD Mutants in Cancer | R-HSA-3656532 | 3.883242e-01 | 0.411 | 0 | 0 |
| Regulation of gap junction activity | R-HSA-191650 | 3.883242e-01 | 0.411 | 0 | 0 |
| Transcriptional activation of p53 responsive genes | R-HSA-69560 | 3.883242e-01 | 0.411 | 0 | 0 |
| Transcriptional activation of cell cycle inhibitor p21 | R-HSA-69895 | 3.883242e-01 | 0.411 | 0 | 0 |
| SARS-CoV-1-mediated effects on programmed cell death | R-HSA-9692913 | 3.883242e-01 | 0.411 | 0 | 0 |
| Activation of NOXA and translocation to mitochondria | R-HSA-111448 | 3.883242e-01 | 0.411 | 0 | 0 |
| p75NTR negatively regulates cell cycle via SC1 | R-HSA-193670 | 3.883242e-01 | 0.411 | 0 | 0 |
| TNFR1-mediated ceramide production | R-HSA-5626978 | 3.883242e-01 | 0.411 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 3.884333e-01 | 0.411 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 3.898444e-01 | 0.409 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 3.903878e-01 | 0.409 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 3.922814e-01 | 0.406 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 3.955244e-01 | 0.403 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 3.956638e-01 | 0.403 | 0 | 0 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | R-HSA-6803205 | 4.023007e-01 | 0.395 | 0 | 0 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 4.056378e-01 | 0.392 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 4.058353e-01 | 0.392 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 4.120473e-01 | 0.385 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 4.145207e-01 | 0.382 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 4.217716e-01 | 0.375 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 4.217716e-01 | 0.375 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 4.239387e-01 | 0.373 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 4.302703e-01 | 0.366 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 4.319424e-01 | 0.365 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 4.326092e-01 | 0.364 | 0 | 0 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | R-HSA-6814122 | 4.326092e-01 | 0.364 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 4.336542e-01 | 0.363 | 0 | 0 |
| Regulation of CDH1 mRNA translation by microRNAs | R-HSA-9764562 | 4.336542e-01 | 0.363 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 4.336542e-01 | 0.363 | 0 | 0 |
| Signaling by FGFR4 in disease | R-HSA-5655291 | 4.336542e-01 | 0.363 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 4.336542e-01 | 0.363 | 0 | 0 |
| HDL assembly | R-HSA-8963896 | 4.336542e-01 | 0.363 | 0 | 0 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | 4.364482e-01 | 0.360 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 4.364482e-01 | 0.360 | 0 | 0 |
| Activation of AKT2 | R-HSA-165158 | 4.364482e-01 | 0.360 | 0 | 0 |
| Reelin signalling pathway | R-HSA-8866376 | 4.364482e-01 | 0.360 | 0 | 0 |
| Suppression of autophagy | R-HSA-9636569 | 4.364482e-01 | 0.360 | 0 | 0 |
| Muscarinic acetylcholine receptors | R-HSA-390648 | 4.364482e-01 | 0.360 | 0 | 0 |
| Assembly of Viral Components at the Budding Site | R-HSA-168316 | 4.364482e-01 | 0.360 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 4.445324e-01 | 0.352 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 4.452997e-01 | 0.351 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 4.452997e-01 | 0.351 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 4.518307e-01 | 0.345 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 4.533862e-01 | 0.344 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 4.533862e-01 | 0.344 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 4.550612e-01 | 0.342 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 4.560752e-01 | 0.341 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 4.609437e-01 | 0.336 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 4.609437e-01 | 0.336 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 4.609437e-01 | 0.336 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 4.609437e-01 | 0.336 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 4.663385e-01 | 0.331 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 4.663385e-01 | 0.331 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 4.679064e-01 | 0.330 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 4.682870e-01 | 0.329 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 4.690207e-01 | 0.329 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 4.691951e-01 | 0.329 | 0 | 0 |
| Nef Mediated CD8 Down-regulation | R-HSA-182218 | 4.807888e-01 | 0.318 | 0 | 0 |
| Phosphorylation of Emi1 | R-HSA-176417 | 4.807888e-01 | 0.318 | 0 | 0 |
| Signaling by Overexpressed Wild-Type EGFR in Cancer | R-HSA-5638302 | 4.807888e-01 | 0.318 | 0 | 0 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | 4.807888e-01 | 0.318 | 0 | 0 |
| Inhibition of Signaling by Overexpressed EGFR | R-HSA-5638303 | 4.807888e-01 | 0.318 | 0 | 0 |
| PKB-mediated events | R-HSA-109703 | 4.807888e-01 | 0.318 | 0 | 0 |
| Ceramide signalling | R-HSA-193681 | 4.807888e-01 | 0.318 | 0 | 0 |
| PDE3B signalling | R-HSA-165160 | 4.807888e-01 | 0.318 | 0 | 0 |
| Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 4.807888e-01 | 0.318 | 0 | 0 |
| VEGF binds to VEGFR leading to receptor dimerization | R-HSA-195399 | 4.807888e-01 | 0.318 | 0 | 0 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | 4.807888e-01 | 0.318 | 0 | 0 |
| VEGF ligand-receptor interactions | R-HSA-194313 | 4.807888e-01 | 0.318 | 0 | 0 |
| Epithelial-Mesenchymal Transition (EMT) during gastrulation | R-HSA-9758919 | 4.807888e-01 | 0.318 | 0 | 0 |
| SLC15A4:TASL-dependent IRF5 activation | R-HSA-9860276 | 4.807888e-01 | 0.318 | 0 | 0 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | 4.807888e-01 | 0.318 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 4.832268e-01 | 0.316 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 4.845127e-01 | 0.315 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 4.845127e-01 | 0.315 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 4.870154e-01 | 0.312 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 4.874474e-01 | 0.312 | 0 | 0 |
| WNT5:FZD7-mediated leishmania damping | R-HSA-9673324 | 4.874474e-01 | 0.312 | 0 | 0 |
| Killing mechanisms | R-HSA-9664420 | 4.874474e-01 | 0.312 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 4.874474e-01 | 0.312 | 0 | 0 |
| Caspase activation via Death Receptors in the presence of ligand | R-HSA-140534 | 4.874474e-01 | 0.312 | 0 | 0 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | R-HSA-399955 | 4.874474e-01 | 0.312 | 0 | 0 |
| Phase 4 - resting membrane potential | R-HSA-5576886 | 4.874474e-01 | 0.312 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 4.874474e-01 | 0.312 | 0 | 0 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | R-HSA-9634600 | 4.874474e-01 | 0.312 | 0 | 0 |
| Receptor-type tyrosine-protein phosphatases | R-HSA-388844 | 4.874474e-01 | 0.312 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 4.940796e-01 | 0.306 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 5.015597e-01 | 0.300 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 5.031131e-01 | 0.298 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 5.046718e-01 | 0.297 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 5.072956e-01 | 0.295 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 5.072956e-01 | 0.295 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 5.072956e-01 | 0.295 | 0 | 0 |
| G beta:gamma signalling through CDC42 | R-HSA-8964616 | 5.131200e-01 | 0.290 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 5.131200e-01 | 0.290 | 0 | 0 |
| Response to metal ions | R-HSA-5660526 | 5.131200e-01 | 0.290 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 5.179097e-01 | 0.286 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 5.179097e-01 | 0.286 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 5.179338e-01 | 0.286 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 5.201458e-01 | 0.284 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 5.201458e-01 | 0.284 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 5.201458e-01 | 0.284 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 5.216430e-01 | 0.283 | 0 | 0 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | 5.216430e-01 | 0.283 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 5.216430e-01 | 0.283 | 0 | 0 |
| G2/M DNA replication checkpoint | R-HSA-69478 | 5.216430e-01 | 0.283 | 0 | 0 |
| Regulation of NFE2L2 gene expression | R-HSA-9818749 | 5.216430e-01 | 0.283 | 0 | 0 |
| CREB phosphorylation | R-HSA-199920 | 5.216430e-01 | 0.283 | 0 | 0 |
| VLDL assembly | R-HSA-8866423 | 5.216430e-01 | 0.283 | 0 | 0 |
| HDL clearance | R-HSA-8964011 | 5.216430e-01 | 0.283 | 0 | 0 |
| Nef and signal transduction | R-HSA-164944 | 5.216430e-01 | 0.283 | 0 | 0 |
| Neurofascin interactions | R-HSA-447043 | 5.216430e-01 | 0.283 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 5.271489e-01 | 0.278 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 5.281779e-01 | 0.277 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 5.368968e-01 | 0.270 | 0 | 0 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 5.379282e-01 | 0.269 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 5.379282e-01 | 0.269 | 0 | 0 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | R-HSA-164938 | 5.379282e-01 | 0.269 | 0 | 0 |
| Modulation of host responses by IFN-stimulated genes | R-HSA-9909505 | 5.379282e-01 | 0.269 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 5.379282e-01 | 0.269 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 5.436051e-01 | 0.265 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 5.447028e-01 | 0.264 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 5.447607e-01 | 0.264 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 5.465497e-01 | 0.262 | 0 | 0 |
| DNA methylation | R-HSA-5334118 | 5.465497e-01 | 0.262 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 5.465497e-01 | 0.262 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 5.492492e-01 | 0.260 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 5.506507e-01 | 0.259 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 5.533480e-01 | 0.257 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 5.554533e-01 | 0.255 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 5.569023e-01 | 0.254 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 5.572794e-01 | 0.254 | 0 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 5.572794e-01 | 0.254 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 5.572794e-01 | 0.254 | 0 | 0 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | 5.592848e-01 | 0.252 | 0 | 0 |
| Defective HLCS causes multiple carboxylase deficiency | R-HSA-3371599 | 5.592848e-01 | 0.252 | 0 | 0 |
| IFNG signaling activates MAPKs | R-HSA-9732724 | 5.592848e-01 | 0.252 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | R-HSA-9031525 | 5.592848e-01 | 0.252 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose | R-HSA-9031528 | 5.592848e-01 | 0.252 | 0 | 0 |
| Disinhibition of SNARE formation | R-HSA-114516 | 5.592848e-01 | 0.252 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | R-HSA-9632974 | 5.592848e-01 | 0.252 | 0 | 0 |
| Insulin effects increased synthesis of Xylulose-5-Phosphate | R-HSA-163754 | 5.592848e-01 | 0.252 | 0 | 0 |
| Microbial modulation of RIPK1-mediated regulated necrosis | R-HSA-9686347 | 5.592848e-01 | 0.252 | 0 | 0 |
| Activation of PUMA and translocation to mitochondria | R-HSA-139915 | 5.592848e-01 | 0.252 | 0 | 0 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | 5.592848e-01 | 0.252 | 0 | 0 |
| LDL remodeling | R-HSA-8964041 | 5.592848e-01 | 0.252 | 0 | 0 |
| CHL1 interactions | R-HSA-447041 | 5.592848e-01 | 0.252 | 0 | 0 |
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 5.592848e-01 | 0.252 | 0 | 0 |
| Polo-like kinase mediated events | R-HSA-156711 | 5.618491e-01 | 0.250 | 0 | 0 |
| Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 5.618491e-01 | 0.250 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 5.618491e-01 | 0.250 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 5.618491e-01 | 0.250 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 5.618491e-01 | 0.250 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 5.654761e-01 | 0.248 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 5.668792e-01 | 0.247 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 5.774670e-01 | 0.238 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 5.835881e-01 | 0.234 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 5.848687e-01 | 0.233 | 0 | 0 |
| phospho-PLA2 pathway | R-HSA-111995 | 5.939667e-01 | 0.226 | 0 | 0 |
| Activated NTRK2 signals through PI3K | R-HSA-9028335 | 5.939667e-01 | 0.226 | 0 | 0 |
| MET receptor recycling | R-HSA-8875656 | 5.939667e-01 | 0.226 | 0 | 0 |
| Regulation by c-FLIP | R-HSA-3371378 | 5.939667e-01 | 0.226 | 0 | 0 |
| Adrenoceptors | R-HSA-390696 | 5.939667e-01 | 0.226 | 0 | 0 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | 5.939667e-01 | 0.226 | 0 | 0 |
| TGFBR3 PTM regulation | R-HSA-9839383 | 5.939667e-01 | 0.226 | 0 | 0 |
| Dimerization of procaspase-8 | R-HSA-69416 | 5.939667e-01 | 0.226 | 0 | 0 |
| Interleukin-23 signaling | R-HSA-9020933 | 5.939667e-01 | 0.226 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 5.959516e-01 | 0.225 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 6.018388e-01 | 0.221 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 6.018388e-01 | 0.221 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 6.069808e-01 | 0.217 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 6.069808e-01 | 0.217 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 6.069808e-01 | 0.217 | 0 | 0 |
| Interferon alpha/beta signaling | R-HSA-909733 | 6.113834e-01 | 0.214 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 6.158596e-01 | 0.211 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 6.160724e-01 | 0.210 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 6.192497e-01 | 0.208 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 6.192497e-01 | 0.208 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 6.192497e-01 | 0.208 | 0 | 0 |
| CASP8 activity is inhibited | R-HSA-5218900 | 6.259212e-01 | 0.203 | 0 | 0 |
| AMPK inhibits chREBP transcriptional activation activity | R-HSA-163680 | 6.259212e-01 | 0.203 | 0 | 0 |
| MASTL Facilitates Mitotic Progression | R-HSA-2465910 | 6.259212e-01 | 0.203 | 0 | 0 |
| Defects in biotin (Btn) metabolism | R-HSA-3323169 | 6.259212e-01 | 0.203 | 0 | 0 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | 6.259212e-01 | 0.203 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 6.259212e-01 | 0.203 | 0 | 0 |
| Regulation of signaling by NODAL | R-HSA-1433617 | 6.259212e-01 | 0.203 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 6.259212e-01 | 0.203 | 0 | 0 |
| Zinc influx into cells by the SLC39 gene family | R-HSA-442380 | 6.259212e-01 | 0.203 | 0 | 0 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 6.281856e-01 | 0.202 | 0 | 0 |
| ERK/MAPK targets | R-HSA-198753 | 6.281856e-01 | 0.202 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 6.281856e-01 | 0.202 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 6.281856e-01 | 0.202 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 6.281856e-01 | 0.202 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 6.306073e-01 | 0.200 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 6.351115e-01 | 0.197 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 6.361353e-01 | 0.196 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 6.361353e-01 | 0.196 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 6.391455e-01 | 0.194 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 6.410916e-01 | 0.193 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 6.410916e-01 | 0.193 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 6.432495e-01 | 0.192 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 6.449863e-01 | 0.190 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 6.484889e-01 | 0.188 | 0 | 0 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | 6.484889e-01 | 0.188 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | R-HSA-9825892 | 6.484889e-01 | 0.188 | 0 | 0 |
| Serine metabolism | R-HSA-977347 | 6.484889e-01 | 0.188 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 6.524906e-01 | 0.185 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 6.524906e-01 | 0.185 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 6.537762e-01 | 0.185 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 6.537762e-01 | 0.185 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 6.537762e-01 | 0.185 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 6.537762e-01 | 0.185 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 6.537762e-01 | 0.185 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 6.553627e-01 | 0.184 | 0 | 0 |
| Binding and entry of HIV virion | R-HSA-173107 | 6.553627e-01 | 0.184 | 0 | 0 |
| Defective RIPK1-mediated regulated necrosis | R-HSA-9693928 | 6.553627e-01 | 0.184 | 0 | 0 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | R-HSA-2151209 | 6.553627e-01 | 0.184 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 6.553627e-01 | 0.184 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 6.665091e-01 | 0.176 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | R-HSA-76071 | 6.679014e-01 | 0.175 | 0 | 0 |
| LDL clearance | R-HSA-8964038 | 6.679014e-01 | 0.175 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 6.683126e-01 | 0.175 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 6.726172e-01 | 0.172 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 6.748262e-01 | 0.171 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 6.782721e-01 | 0.169 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 6.782721e-01 | 0.169 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 6.824886e-01 | 0.166 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 6.824886e-01 | 0.166 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 6.824886e-01 | 0.166 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 6.824886e-01 | 0.166 | 0 | 0 |
| Chylomicron assembly | R-HSA-8963888 | 6.824886e-01 | 0.166 | 0 | 0 |
| RHOBTB3 ATPase cycle | R-HSA-9706019 | 6.824886e-01 | 0.166 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 6.824886e-01 | 0.166 | 0 | 0 |
| Suppression of apoptosis | R-HSA-9635465 | 6.824886e-01 | 0.166 | 0 | 0 |
| CD163 mediating an anti-inflammatory response | R-HSA-9662834 | 6.824886e-01 | 0.166 | 0 | 0 |
| Dissolution of Fibrin Clot | R-HSA-75205 | 6.824886e-01 | 0.166 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 6.836010e-01 | 0.165 | 0 | 0 |
| Triglyceride catabolism | R-HSA-163560 | 6.836010e-01 | 0.165 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 6.864373e-01 | 0.163 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 6.951300e-01 | 0.158 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 6.969313e-01 | 0.157 | 0 | 0 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 6.983572e-01 | 0.156 | 1 | 1 |
| PI3K Cascade | R-HSA-109704 | 6.987247e-01 | 0.156 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 6.987247e-01 | 0.156 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 7.015826e-01 | 0.154 | 0 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 7.030683e-01 | 0.153 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 7.041144e-01 | 0.152 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 1 | R-HSA-418592 | 7.041144e-01 | 0.152 | 0 | 0 |
| Mitochondrial RNA degradation | R-HSA-9836573 | 7.041144e-01 | 0.152 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | R-HSA-9623433 | 7.074810e-01 | 0.150 | 0 | 0 |
| Synthesis of diphthamide-EEF2 | R-HSA-5358493 | 7.074810e-01 | 0.150 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 7.074810e-01 | 0.150 | 0 | 0 |
| ERKs are inactivated | R-HSA-202670 | 7.074810e-01 | 0.150 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 7.074810e-01 | 0.150 | 0 | 0 |
| Endosomal/Vacuolar pathway | R-HSA-1236977 | 7.074810e-01 | 0.150 | 0 | 0 |
| Sensing of DNA Double Strand Breaks | R-HSA-5693548 | 7.074810e-01 | 0.150 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 7.074810e-01 | 0.150 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 7.074810e-01 | 0.150 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 7.074810e-01 | 0.150 | 0 | 0 |
| Viral RNP Complexes in the Host Cell Nucleus | R-HSA-168330 | 7.074810e-01 | 0.150 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 7.074810e-01 | 0.150 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 7.074810e-01 | 0.150 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 7.101890e-01 | 0.149 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 7.125848e-01 | 0.147 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 7.209531e-01 | 0.142 | 0 | 0 |
| PIWI-interacting RNA (piRNA) biogenesis | R-HSA-5601884 | 7.209531e-01 | 0.142 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 7.237110e-01 | 0.140 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 7.241226e-01 | 0.140 | 1 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 7.262887e-01 | 0.139 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | R-HSA-381771 | 7.262887e-01 | 0.139 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 7.305075e-01 | 0.136 | 0 | 0 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 7.305075e-01 | 0.136 | 0 | 0 |
| Serotonin clearance from the synaptic cleft | R-HSA-380615 | 7.305075e-01 | 0.136 | 0 | 0 |
| Role of second messengers in netrin-1 signaling | R-HSA-418890 | 7.305075e-01 | 0.136 | 0 | 0 |
| Trafficking and processing of endosomal TLR | R-HSA-1679131 | 7.305075e-01 | 0.136 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 7.305075e-01 | 0.136 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 7.305075e-01 | 0.136 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 7.305075e-01 | 0.136 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 7.324386e-01 | 0.135 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 7.369757e-01 | 0.133 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 7.369757e-01 | 0.133 | 0 | 0 |
| Caspase activation via extrinsic apoptotic signalling pathway | R-HSA-5357769 | 7.369757e-01 | 0.133 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 7.369757e-01 | 0.133 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 7.369757e-01 | 0.133 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 7.383783e-01 | 0.132 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 7.394754e-01 | 0.131 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 7.394754e-01 | 0.131 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 7.478668e-01 | 0.126 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 7.517227e-01 | 0.124 | 0 | 0 |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | 7.517227e-01 | 0.124 | 0 | 0 |
| Processing of SMDT1 | R-HSA-8949664 | 7.517227e-01 | 0.124 | 0 | 0 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 7.517227e-01 | 0.124 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 7.517227e-01 | 0.124 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9683610 | 7.517227e-01 | 0.124 | 0 | 0 |
| Interleukin-6 signaling | R-HSA-1059683 | 7.517227e-01 | 0.124 | 0 | 0 |
| Replication of the SARS-CoV-1 genome | R-HSA-9682706 | 7.517227e-01 | 0.124 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 7.521526e-01 | 0.124 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 7.521526e-01 | 0.124 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 7.521526e-01 | 0.124 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 7.522064e-01 | 0.124 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 7.522064e-01 | 0.124 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 7.522064e-01 | 0.124 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 7.522064e-01 | 0.124 | 0 | 0 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 7.522064e-01 | 0.124 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 7.643291e-01 | 0.117 | 0 | 0 |
| Scavenging by Class A Receptors | R-HSA-3000480 | 7.643291e-01 | 0.117 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 7.643291e-01 | 0.117 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 7.650027e-01 | 0.116 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 7.666705e-01 | 0.115 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 7.666705e-01 | 0.115 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR3 | R-HSA-5654227 | 7.712689e-01 | 0.113 | 0 | 0 |
| TP53 Regulates Transcription of Death Receptors and Ligands | R-HSA-6803211 | 7.712689e-01 | 0.113 | 0 | 0 |
| Removal of the Flap Intermediate | R-HSA-69166 | 7.712689e-01 | 0.113 | 0 | 0 |
| Hydrolysis of LPC | R-HSA-1483115 | 7.712689e-01 | 0.113 | 0 | 0 |
| CLEC7A (Dectin-1) induces NFAT activation | R-HSA-5607763 | 7.712689e-01 | 0.113 | 0 | 0 |
| Physiological factors | R-HSA-5578768 | 7.712689e-01 | 0.113 | 0 | 0 |
| Respiratory syncytial virus genome transcription | R-HSA-9828642 | 7.712689e-01 | 0.113 | 0 | 0 |
| Acyl chain remodeling of CL | R-HSA-1482798 | 7.712689e-01 | 0.113 | 0 | 0 |
| Zinc transporters | R-HSA-435354 | 7.712689e-01 | 0.113 | 0 | 0 |
| SARS-CoV-1 Genome Replication and Transcription | R-HSA-9679514 | 7.712689e-01 | 0.113 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 7.760147e-01 | 0.110 | 0 | 0 |
| Incretin synthesis, secretion, and inactivation | R-HSA-400508 | 7.760147e-01 | 0.110 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 7.760147e-01 | 0.110 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 7.760147e-01 | 0.110 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 7.781434e-01 | 0.109 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 7.803943e-01 | 0.108 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 7.803943e-01 | 0.108 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 7.803943e-01 | 0.108 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 7.855478e-01 | 0.105 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 7.871806e-01 | 0.104 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 7.872199e-01 | 0.104 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 7.875288e-01 | 0.104 | 0 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 7.880118e-01 | 0.103 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 7.892774e-01 | 0.103 | 0 | 0 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 7.892774e-01 | 0.103 | 0 | 0 |
| G beta:gamma signalling through BTK | R-HSA-8964315 | 7.892774e-01 | 0.103 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR4 | R-HSA-5654228 | 7.892774e-01 | 0.103 | 0 | 0 |
| Telomere C-strand synthesis initiation | R-HSA-174430 | 7.892774e-01 | 0.103 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 7.892774e-01 | 0.103 | 0 | 0 |
| Signaling by Activin | R-HSA-1502540 | 7.892774e-01 | 0.103 | 0 | 0 |
| Biotin transport and metabolism | R-HSA-196780 | 7.892774e-01 | 0.103 | 0 | 0 |
| Lysosphingolipid and LPA receptors | R-HSA-419408 | 7.892774e-01 | 0.103 | 0 | 0 |
| Disease | R-HSA-1643685 | 7.910660e-01 | 0.102 | 1 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 7.917103e-01 | 0.101 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 7.917103e-01 | 0.101 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 7.929424e-01 | 0.101 | 0 | 0 |
| DAP12 signaling | R-HSA-2424491 | 7.934046e-01 | 0.101 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 7.934046e-01 | 0.101 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 7.934046e-01 | 0.101 | 0 | 0 |
| NOTCH3 Intracellular Domain Regulates Transcription | R-HSA-9013508 | 7.934046e-01 | 0.101 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 7.950758e-01 | 0.100 | 0 | 0 |
| Triglyceride metabolism | R-HSA-8979227 | 7.975261e-01 | 0.098 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 7.979561e-01 | 0.098 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 8.057288e-01 | 0.094 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 8.057288e-01 | 0.094 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 8.058690e-01 | 0.094 | 0 | 0 |
| Entry of Influenza Virion into Host Cell via Endocytosis | R-HSA-168275 | 8.058690e-01 | 0.094 | 0 | 0 |
| Defective GALNT12 causes CRCS1 | R-HSA-5083636 | 8.058690e-01 | 0.094 | 0 | 0 |
| Defective GALNT3 causes HFTC | R-HSA-5083625 | 8.058690e-01 | 0.094 | 0 | 0 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | R-HSA-6803207 | 8.058690e-01 | 0.094 | 0 | 0 |
| Class I peroxisomal membrane protein import | R-HSA-9603798 | 8.058690e-01 | 0.094 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 8.058690e-01 | 0.094 | 0 | 0 |
| Activation of SMO | R-HSA-5635838 | 8.058690e-01 | 0.094 | 0 | 0 |
| Attachment and Entry | R-HSA-9678110 | 8.058690e-01 | 0.094 | 0 | 0 |
| Virus Assembly and Release | R-HSA-168268 | 8.058690e-01 | 0.094 | 0 | 0 |
| RAB geranylgeranylation | R-HSA-8873719 | 8.066927e-01 | 0.093 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 8.082351e-01 | 0.092 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 8.082351e-01 | 0.092 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 8.085424e-01 | 0.092 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 8.155186e-01 | 0.089 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 8.155186e-01 | 0.089 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 8.173941e-01 | 0.088 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 8.173941e-01 | 0.088 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 8.173941e-01 | 0.088 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 8.180691e-01 | 0.087 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 8.180691e-01 | 0.087 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 8.193976e-01 | 0.087 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 8.211552e-01 | 0.086 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 8.211552e-01 | 0.086 | 0 | 0 |
| Passive transport by Aquaporins | R-HSA-432047 | 8.211552e-01 | 0.086 | 0 | 0 |
| Synthesis of PG | R-HSA-1483148 | 8.211552e-01 | 0.086 | 0 | 0 |
| Disorders of Developmental Biology | R-HSA-9675151 | 8.211552e-01 | 0.086 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | R-HSA-400511 | 8.211552e-01 | 0.086 | 0 | 0 |
| Coenzyme A biosynthesis | R-HSA-196783 | 8.211552e-01 | 0.086 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 8.240109e-01 | 0.084 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 8.240109e-01 | 0.084 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 8.284279e-01 | 0.082 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 8.284279e-01 | 0.082 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 8.316155e-01 | 0.080 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 8.321770e-01 | 0.080 | 0 | 0 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 8.352385e-01 | 0.078 | 0 | 0 |
| Defective C1GALT1C1 causes TNPS | R-HSA-5083632 | 8.352385e-01 | 0.078 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 8.352385e-01 | 0.078 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 8.352385e-01 | 0.078 | 0 | 0 |
| Replication of the SARS-CoV-2 genome | R-HSA-9694686 | 8.352385e-01 | 0.078 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 8.364530e-01 | 0.078 | 0 | 0 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 8.388573e-01 | 0.076 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 8.388573e-01 | 0.076 | 0 | 0 |
| Vitamin B5 (pantothenate) metabolism | R-HSA-199220 | 8.388573e-01 | 0.076 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 8.400248e-01 | 0.076 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 8.475621e-01 | 0.072 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 8.482137e-01 | 0.071 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 8.482137e-01 | 0.071 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 8.482137e-01 | 0.071 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 8.482137e-01 | 0.071 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 8.482137e-01 | 0.071 | 0 | 0 |
| Synaptic adhesion-like molecules | R-HSA-8849932 | 8.482137e-01 | 0.071 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 8.487089e-01 | 0.071 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 8.487089e-01 | 0.071 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 8.487089e-01 | 0.071 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 8.487089e-01 | 0.071 | 0 | 0 |
| Regulation of TLR by endogenous ligand | R-HSA-5686938 | 8.487089e-01 | 0.071 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 8.487089e-01 | 0.071 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 8.552272e-01 | 0.068 | 0 | 0 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 8.580092e-01 | 0.067 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 8.580092e-01 | 0.067 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 8.580092e-01 | 0.067 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 8.580092e-01 | 0.067 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 8.580092e-01 | 0.067 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 8.601677e-01 | 0.065 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 8.601677e-01 | 0.065 | 0 | 0 |
| Prostacyclin signalling through prostacyclin receptor | R-HSA-392851 | 8.601677e-01 | 0.065 | 0 | 0 |
| Specification of the neural plate border | R-HSA-9834899 | 8.601677e-01 | 0.065 | 0 | 0 |
| Other interleukin signaling | R-HSA-449836 | 8.601677e-01 | 0.065 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 8.601677e-01 | 0.065 | 0 | 0 |
| Strand-asynchronous mitochondrial DNA replication | R-HSA-9913635 | 8.601677e-01 | 0.065 | 0 | 0 |
| SARS-CoV-2 Genome Replication and Transcription | R-HSA-9694682 | 8.601677e-01 | 0.065 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 8.610148e-01 | 0.065 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 8.610148e-01 | 0.065 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 8.615852e-01 | 0.065 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 8.647533e-01 | 0.063 | 0 | 0 |
| Glycosphingolipid transport | R-HSA-9845576 | 8.667837e-01 | 0.062 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 8.667837e-01 | 0.062 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 8.684512e-01 | 0.061 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 8.688650e-01 | 0.061 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 8.711809e-01 | 0.060 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR2 | R-HSA-5654221 | 8.711809e-01 | 0.060 | 0 | 0 |
| Formation of ATP by chemiosmotic coupling | R-HSA-163210 | 8.711809e-01 | 0.060 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 8.711809e-01 | 0.060 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 8.711809e-01 | 0.060 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 8.711809e-01 | 0.060 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 8.711809e-01 | 0.060 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 8.711809e-01 | 0.060 | 0 | 0 |
| Acyl chain remodelling of PI | R-HSA-1482922 | 8.711809e-01 | 0.060 | 0 | 0 |
| Creatine metabolism | R-HSA-71288 | 8.711809e-01 | 0.060 | 0 | 0 |
| Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 8.711809e-01 | 0.060 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 8.716280e-01 | 0.060 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 8.750577e-01 | 0.058 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 8.750577e-01 | 0.058 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 8.764214e-01 | 0.057 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 8.795066e-01 | 0.056 | 0 | 0 |
| G-protein activation | R-HSA-202040 | 8.813274e-01 | 0.055 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 12 | R-HSA-392170 | 8.813274e-01 | 0.055 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 8.813274e-01 | 0.055 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 8.813274e-01 | 0.055 | 0 | 0 |
| Synthesis, secretion, and deacylation of Ghrelin | R-HSA-422085 | 8.813274e-01 | 0.055 | 0 | 0 |
| Acyl chain remodelling of PG | R-HSA-1482925 | 8.813274e-01 | 0.055 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 8.822768e-01 | 0.054 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 8.828554e-01 | 0.054 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 8.828554e-01 | 0.054 | 0 | 0 |
| Depurination | R-HSA-73927 | 8.828554e-01 | 0.054 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 8.886920e-01 | 0.051 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 8.902006e-01 | 0.051 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 8.902006e-01 | 0.051 | 0 | 0 |
| FOXO-mediated transcription of cell cycle genes | R-HSA-9617828 | 8.906752e-01 | 0.050 | 0 | 0 |
| Molybdenum cofactor biosynthesis | R-HSA-947581 | 8.906752e-01 | 0.050 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 8.906752e-01 | 0.050 | 0 | 0 |
| Ribavirin ADME | R-HSA-9755088 | 8.906752e-01 | 0.050 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 8.941993e-01 | 0.049 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 8.947926e-01 | 0.048 | 0 | 0 |
| Mitochondrial tRNA aminoacylation | R-HSA-379726 | 8.971161e-01 | 0.047 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 8.971161e-01 | 0.047 | 0 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 8.992872e-01 | 0.046 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 8.992872e-01 | 0.046 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 8.997952e-01 | 0.046 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 9.036241e-01 | 0.044 | 0 | 0 |
| Purine ribonucleoside monophosphate biosynthesis | R-HSA-73817 | 9.036241e-01 | 0.044 | 0 | 0 |
| Termination of O-glycan biosynthesis | R-HSA-977068 | 9.072212e-01 | 0.042 | 0 | 0 |
| Mitochondrial mRNA modification | R-HSA-9937008 | 9.072212e-01 | 0.042 | 0 | 0 |
| Organic anion transport by SLCO transporters | R-HSA-879518 | 9.072212e-01 | 0.042 | 0 | 0 |
| Carnitine shuttle | R-HSA-200425 | 9.072212e-01 | 0.042 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 9.097457e-01 | 0.041 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 9.104923e-01 | 0.041 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 9.113302e-01 | 0.040 | 0 | 0 |
| Thromboxane signalling through TP receptor | R-HSA-428930 | 9.145307e-01 | 0.039 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 9.145307e-01 | 0.039 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 9.145307e-01 | 0.039 | 0 | 0 |
| Complex III assembly | R-HSA-9865881 | 9.145307e-01 | 0.039 | 0 | 0 |
| Interleukin-6 family signaling | R-HSA-6783589 | 9.145307e-01 | 0.039 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 9.162948e-01 | 0.038 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 9.196193e-01 | 0.036 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 9.209111e-01 | 0.036 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 9.210047e-01 | 0.036 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 9.212647e-01 | 0.036 | 0 | 0 |
| G protein gated Potassium channels | R-HSA-1296059 | 9.212647e-01 | 0.036 | 0 | 0 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | R-HSA-997272 | 9.212647e-01 | 0.036 | 0 | 0 |
| Activation of G protein gated Potassium channels | R-HSA-1296041 | 9.212647e-01 | 0.036 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 9.212647e-01 | 0.036 | 0 | 0 |
| MicroRNA (miRNA) biogenesis | R-HSA-203927 | 9.212647e-01 | 0.036 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 9.212647e-01 | 0.036 | 0 | 0 |
| Formation of the nephric duct | R-HSA-9830364 | 9.212647e-01 | 0.036 | 0 | 0 |
| Laminin interactions | R-HSA-3000157 | 9.212647e-01 | 0.036 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 9.251207e-01 | 0.034 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 9.254711e-01 | 0.034 | 0 | 0 |
| DAP12 interactions | R-HSA-2172127 | 9.259932e-01 | 0.033 | 0 | 0 |
| Amine ligand-binding receptors | R-HSA-375280 | 9.259932e-01 | 0.033 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 9.270976e-01 | 0.033 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.270976e-01 | 0.033 | 0 | 0 |
| MET activates PTK2 signaling | R-HSA-8874081 | 9.274685e-01 | 0.033 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 9.274685e-01 | 0.033 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 9.274685e-01 | 0.033 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 9.274685e-01 | 0.033 | 0 | 0 |
| Urea cycle | R-HSA-70635 | 9.274685e-01 | 0.033 | 0 | 0 |
| Sphingolipid catabolism | R-HSA-9845614 | 9.274685e-01 | 0.033 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 9.308737e-01 | 0.031 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 9.322183e-01 | 0.030 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 9.326775e-01 | 0.030 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 9.330554e-01 | 0.030 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 9.330554e-01 | 0.030 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 9.331838e-01 | 0.030 | 0 | 0 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 9.331838e-01 | 0.030 | 0 | 0 |
| Triglyceride biosynthesis | R-HSA-75109 | 9.331838e-01 | 0.030 | 0 | 0 |
| Synthesis of PE | R-HSA-1483213 | 9.331838e-01 | 0.030 | 0 | 0 |
| Maturation of hRSV A proteins | R-HSA-9828806 | 9.331838e-01 | 0.030 | 0 | 0 |
| Signaling by BMP | R-HSA-201451 | 9.331838e-01 | 0.030 | 0 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 9.352464e-01 | 0.029 | 0 | 0 |
| Insulin receptor recycling | R-HSA-77387 | 9.384491e-01 | 0.028 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 9.384491e-01 | 0.028 | 0 | 0 |
| ATF4 activates genes in response to endoplasmic reticulum stress | R-HSA-380994 | 9.384491e-01 | 0.028 | 0 | 0 |
| Pyrimidine salvage | R-HSA-73614 | 9.384491e-01 | 0.028 | 0 | 0 |
| Synthesis of PC | R-HSA-1483191 | 9.394511e-01 | 0.027 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 9.415424e-01 | 0.026 | 0 | 0 |
| Thyroxine biosynthesis | R-HSA-209968 | 9.432998e-01 | 0.025 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 9.432998e-01 | 0.025 | 0 | 0 |
| Glucagon-type ligand receptors | R-HSA-420092 | 9.432998e-01 | 0.025 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 9.477384e-01 | 0.023 | 0 | 0 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 9.477684e-01 | 0.023 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 9.477684e-01 | 0.023 | 0 | 0 |
| Neurotransmitter clearance | R-HSA-112311 | 9.477684e-01 | 0.023 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 9.477684e-01 | 0.023 | 0 | 0 |
| Azathioprine ADME | R-HSA-9748787 | 9.505626e-01 | 0.022 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 9.518852e-01 | 0.021 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 9.524480e-01 | 0.021 | 0 | 0 |
| Inwardly rectifying K+ channels | R-HSA-1296065 | 9.556776e-01 | 0.020 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 9.558947e-01 | 0.020 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.563859e-01 | 0.019 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.565733e-01 | 0.019 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 9.568582e-01 | 0.019 | 0 | 0 |
| Interconversion of nucleotide di- and triphosphates | R-HSA-499943 | 9.589572e-01 | 0.018 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 9.591714e-01 | 0.018 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 9.591714e-01 | 0.018 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 9.597106e-01 | 0.018 | 0 | 0 |
| Nucleotide biosynthesis | R-HSA-8956320 | 9.597106e-01 | 0.018 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 9.623900e-01 | 0.017 | 0 | 0 |
| Glutamate and glutamine metabolism | R-HSA-8964539 | 9.623900e-01 | 0.017 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 9.623900e-01 | 0.017 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 9.653550e-01 | 0.015 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 9.680864e-01 | 0.014 | 0 | 0 |
| Defects in vitamin and cofactor metabolism | R-HSA-3296482 | 9.680864e-01 | 0.014 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 9.689232e-01 | 0.014 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 9.706026e-01 | 0.013 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 9.706026e-01 | 0.013 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 9.706026e-01 | 0.013 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 9.706434e-01 | 0.013 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 9.714606e-01 | 0.013 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 9.724534e-01 | 0.012 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 9.724534e-01 | 0.012 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 9.724534e-01 | 0.012 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 9.733763e-01 | 0.012 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 9.733763e-01 | 0.012 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.739860e-01 | 0.011 | 0 | 0 |
| tRNA processing in the mitochondrion | R-HSA-6785470 | 9.750559e-01 | 0.011 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 9.750559e-01 | 0.011 | 0 | 0 |
| Purine salvage | R-HSA-74217 | 9.750559e-01 | 0.011 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 9.751675e-01 | 0.011 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 9.752846e-01 | 0.011 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 9.752846e-01 | 0.011 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 9.764751e-01 | 0.010 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 9.779859e-01 | 0.010 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 9.784068e-01 | 0.009 | 0 | 0 |
| rRNA processing in the mitochondrion | R-HSA-8868766 | 9.788350e-01 | 0.009 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 9.801649e-01 | 0.009 | 0 | 0 |
| CD22 mediated BCR regulation | R-HSA-5690714 | 9.812350e-01 | 0.008 | 0 | 0 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | R-HSA-9615017 | 9.820420e-01 | 0.008 | 0 | 0 |
| Activation of GABAB receptors | R-HSA-991365 | 9.834585e-01 | 0.007 | 0 | 0 |
| GABA B receptor activation | R-HSA-977444 | 9.834585e-01 | 0.007 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.839126e-01 | 0.007 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 9.848147e-01 | 0.007 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 9.854067e-01 | 0.006 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 9.854067e-01 | 0.006 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.858531e-01 | 0.006 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 9.870452e-01 | 0.006 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 9.875558e-01 | 0.005 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.877267e-01 | 0.005 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 9.883343e-01 | 0.005 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 9.885705e-01 | 0.005 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.898470e-01 | 0.004 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 9.898974e-01 | 0.004 | 0 | 0 |
| Plasma lipoprotein remodeling | R-HSA-8963899 | 9.898974e-01 | 0.004 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.906946e-01 | 0.004 | 0 | 0 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | R-HSA-2162123 | 9.914290e-01 | 0.004 | 0 | 0 |
| Cytosolic sulfonation of small molecules | R-HSA-156584 | 9.921054e-01 | 0.003 | 0 | 0 |
| Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 9.926100e-01 | 0.003 | 0 | 0 |
| Interleukin-10 signaling | R-HSA-6783783 | 9.930811e-01 | 0.003 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.933499e-01 | 0.003 | 0 | 0 |
| Developmental Lineage of Pancreatic Acinar Cells | R-HSA-9925561 | 9.935628e-01 | 0.003 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 9.937021e-01 | 0.003 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.939364e-01 | 0.003 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.942199e-01 | 0.003 | 0 | 0 |
| Metabolism of amine-derived hormones | R-HSA-209776 | 9.947666e-01 | 0.002 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.951798e-01 | 0.002 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.951798e-01 | 0.002 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 9.952327e-01 | 0.002 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.953913e-01 | 0.002 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.953913e-01 | 0.002 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 9.957394e-01 | 0.002 | 0 | 0 |
| GABA receptor activation | R-HSA-977443 | 9.962338e-01 | 0.002 | 0 | 0 |
| Signaling by Retinoic Acid | R-HSA-5362517 | 9.962338e-01 | 0.002 | 0 | 0 |
| Nucleotide salvage | R-HSA-8956321 | 9.965312e-01 | 0.002 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 9.966472e-01 | 0.001 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 9.966472e-01 | 0.001 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 9.966472e-01 | 0.001 | 0 | 0 |
| Classical antibody-mediated complement activation | R-HSA-173623 | 9.968890e-01 | 0.001 | 0 | 0 |
| Complex I biogenesis | R-HSA-6799198 | 9.970575e-01 | 0.001 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.972834e-01 | 0.001 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 9.973131e-01 | 0.001 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.977011e-01 | 0.001 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 9.977834e-01 | 0.001 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 9.978827e-01 | 0.001 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 9.978833e-01 | 0.001 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.979827e-01 | 0.001 | 0 | 0 |
| FCGR activation | R-HSA-2029481 | 9.979978e-01 | 0.001 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 9.980261e-01 | 0.001 | 0 | 0 |
| O-linked glycosylation of mucins | R-HSA-913709 | 9.980500e-01 | 0.001 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 9.981967e-01 | 0.001 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 9.983459e-01 | 0.001 | 0 | 0 |
| Glycosphingolipid catabolism | R-HSA-9840310 | 9.983459e-01 | 0.001 | 0 | 0 |
| Scavenging of heme from plasma | R-HSA-2168880 | 9.983955e-01 | 0.001 | 0 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.984766e-01 | 0.001 | 0 | 0 |
| SLC-mediated transport of organic anions | R-HSA-9955298 | 9.991439e-01 | 0.000 | 0 | 0 |
| Regulation of Complement cascade | R-HSA-977606 | 9.991526e-01 | 0.000 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.991930e-01 | 0.000 | 0 | 0 |
| Creation of C4 and C2 activators | R-HSA-166786 | 9.993427e-01 | 0.000 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 9.994329e-01 | 0.000 | 0 | 0 |
| Initial triggering of complement | R-HSA-166663 | 9.996655e-01 | 0.000 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.997360e-01 | 0.000 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 9.997733e-01 | 0.000 | 0 | 0 |
| Complement cascade | R-HSA-166658 | 9.998434e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation elongation | R-HSA-5389840 | 9.998483e-01 | 0.000 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.998642e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation initiation | R-HSA-5368286 | 9.998714e-01 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 9.998962e-01 | 0.000 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.999026e-01 | 0.000 | 0 | 0 |
| Mitochondrial ribosome-associated quality control | R-HSA-9937383 | 9.999148e-01 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 9.999233e-01 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 9.999516e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation termination | R-HSA-5419276 | 9.999522e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.999551e-01 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 9.999691e-01 | 0.000 | 0 | 0 |
| Glycosphingolipid metabolism | R-HSA-1660662 | 9.999872e-01 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 9.999875e-01 | 0.000 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 9.999918e-01 | 0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 9.999930e-01 | 0.000 | 0 | 0 |
| O-linked glycosylation | R-HSA-5173105 | 9.999969e-01 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 9.999970e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation | R-HSA-5368287 | 9.999971e-01 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 9.999981e-01 | 0.000 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 9.999994e-01 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 9.999996e-01 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 9.999999e-01 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 9.999999e-01 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 9.999999e-01 | 0.000 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 1.000000e+00 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase I - Functionalization of compounds | R-HSA-211945 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase II - Conjugation of compounds | R-HSA-156580 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | 0.000 | 0 | 0 |
| Expression and translocation of olfactory receptors | R-HSA-9752946 | 1.000000e+00 | -0.000 | 0 | 0 |
| Olfactory Signaling Pathway | R-HSA-381753 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
