PAK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	T789	Sugiyama	POTEF A26C1B	YPMEHGIITNWDDMEKIWHHtFyNELRVAPEEHPVLLTEAT
A8MUU1	T51	Sugiyama	FABP5P3 FABP5L3	FSGTLGEKFEENTADGRRTQtVCNFTDGALVQHQEWDGKES
B2RPK0	S15	Sugiyama	HMGB1P1 HMG1L1 HMGB1L1	______MGKGDPKKPRGKMssyAFFVQtCREEHKKKHSDAS
O00488	S93	Sugiyama	ZNF593 ZT86	STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O00571	S594	Sugiyama	DDX3X DBX DDX3	MAyEHHyKGssRGRSKssRFsGGFGARDYRQssGAssssFs
O00571	S606	Sugiyama	DDX3X DBX DDX3	GRSKssRFsGGFGARDYRQssGAssssFsssRAsSsRSGGG
O14737	S42	Sugiyama	PDCD5 TFAR19	GDPGDAAQQEAKHREAEMRNsILAQVLDQsARARLsNLALV
O14974	S692	Sugiyama	PPP1R12A MBS MYPT1	PVRDEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIG
O14974	S695	Sugiyama	PPP1R12A MBS MYPT1	DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974	S912	Sugiyama	PPP1R12A MBS MYPT1	TssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDSTDF
O14974	T696	Sugiyama	PPP1R12A MBS MYPT1	EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O15013	S1232	Sugiyama	ARHGEF10 KIAA0294	VKFIVLATALHEKDKDKsRDsLAPGPEPQDEDQKDALPSGG
O15212	T107	Sugiyama	PFDN6 HKE2 PFD6	IKRYESQLRDLERQsEQQREtLAQLQQEFQRAQAAKAGAPG
O15372	S290	Sugiyama	EIF3H EIF3S3	QQQQKHQYQQRRQQENMQRQsRGEPPLPEEDLsKLFKPPQP
O43290	S670	Sugiyama	SART1	LLETTVQKVARVKAPNKSLPsAVyCIEDKMAIDDKYSRREE
O43318	S389	Sugiyama	MAP3K7 TAK1	GASRGssVESLPPTSEGKRMsADMsEIEARIAATTAYSKPK
O43399	S104	Sugiyama	TPD52L2	stLGELKQNLsRsWHDVQVssAyVKTSEKLGEWNEKVTQSD
O43423	S100	Sugiyama	ANP32CP PP32R1	AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43488	S40	Sugiyama	AKR7A2 AFAR AFAR1 AKR7	SPPPEARALAMSRPPPPRVAsVLGTMEMGRRMDAPAsAAAV
O43707	S423	Sugiyama	ACTN4	NEIRRLERLDHLAEKFRQKAsIHEAWtDGKEAMLKHRDyEt
O43823	S124	Sugiyama	AKAP8 AKAP95	SKEGGRGGsGGGGEGIQDREssFRFQPFESYDSRPCLPEHN
O60220	S57	Sugiyama	TIMM8A DDP DDP1 TIM8A	HQMTELCWEKCMDKPGPKLDsRAEACFVNCVERFIDTSQFI
O60220	S94	Sugiyama	TIMM8A DDP DDP1 TIM8A	SQFILNRLEQTQKSKPVFSEsLsD_________________
O60493	S72	Sugiyama	SNX3	RVKTNLPIFKLKESTVRRRysDFEWLRSELERESKVVVPPL
O60573	T73	Sugiyama	EIF4E2 EIF4EL3	EHPLQYNYTFWYSRRtPGRPtsSQSyEQNIKQIGTFASVEQ
O60664	S175	Sugiyama	PLIN3 M6PRBP1 TIP47	RGAVQSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGK
O60814	S39	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75116	S762	Sugiyama	ROCK2 KIAA0619	EERTLKQKVENLLLEAEKRCsLLDCDLKQSQQKINELLKQK
O75157	S205	Sugiyama	TSC22D2 KIAA0669 TILZ4	yYERDSDSSVLTRSGDCIRHssTFDQTAERDSGLGATGGSV
O75533	T125	Sugiyama	SF3B1 SAP155	AEHRPPKIADREDEYKKHRRtMIIsPERLDPFADGGKtPDP
O75534	S584	Sugiyama	CSDE1 D1S155E KIAA0885 NRU UNR	YSLSKGKGNKVSAEKVNKtHsVNGItEEADPTIysGKVIRP
O75665	S899	Sugiyama	OFD1 CXorf5	EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O75914	S120	Sugiyama	PAK3 OPHN3	MCPGKLPEGIPEQWARLLQtsNItKLEQKKNPQAVLDVLKF
O94804	S454	Sugiyama	STK10 LOK	GGDLsPAANRsQKAsQsRPNssALEtLGGEKLANGsLEPPA
O95336	T74	Sugiyama	PGLS	LARELPAAVAPAGPASLARWtLGFCDERLVPFDHAEStyGL
O95626	S104	Sugiyama	ANP32D PP32R2	AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95678	S162	Sugiyama	KRT75 K6HF KB18	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95757	S599	Sugiyama	HSPA4L APG1 HSPH3 OSP94	sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338	S237	Sugiyama	LDHA PIG19	DLGtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVA
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00491	S176	Sugiyama	PNP NP	GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00519	S618	GPS6\|SIGNOR\|EPSD\|PSP	ABL1 ABL JTK7	NLFSALIKKKKKTAPTPPKRsssFREMDGQPERRGAGEEEG
P00519	S619	GPS6\|SIGNOR\|EPSD\|PSP	ABL1 ABL JTK7	LFSALIKKKKKTAPTPPKRsssFREMDGQPERRGAGEEEGR
P00558	S174	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558	S175	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P01106	S388	PSP	MYC BHLHE39	NVKRRtHNVLERQRRNELKRsFFALRDQIPELENNEKAPKV
P01106	T373	PSP	MYC BHLHE39	NNRKCtsPRssDTEENVKRRtHNVLERQRRNELKRsFFALR
P01106	T415	PSP	MYC BHLHE39	QIPELENNEKAPKVVILKKAtAYILSVQAEEQKLISEEDLL
P01236	S207	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	PRL	ADEESRLsAYYNLLHCLRRDsHKIDNYLKLLKCRIIHNNNC
P02538	S176	Sugiyama	KRT6A K6A KRT6D	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P02545	S282	Sugiyama	LMNA LMN1	ELEKTYSAKLDNARQsAERNsNLVGAAHEELQQsRIRIDsL
P04040	S517	Sugiyama	CAT	LDKYNAEKPKNAIHtFVQsGsHLAAREKANL__________
P04040	T511	Sugiyama	CAT	SHIQALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL____
P04049	S338	GPS6\|ELM\|EPSD\|PSP	RAF1 RAF	RAPVsGtQEKNKIRPRGQRDssyyWEIEASEVMLSTRIGsG
P04049	S339	GPS6	RAF1 RAF	APVsGtQEKNKIRPRGQRDssyyWEIEASEVMLSTRIGsGs
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04259	S176	Sugiyama	KRT6B K6B KRTL1	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	S312	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P05141	T107	PSP	SLC25A5 AAC2 ANT2	LNFAFKDKYKQIFLGGVDKRtQFWLYFAGNLASGGAAGATS
P05362	S43	Sugiyama	ICAM1	GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05387	S29	Sugiyama	RPLP2 D11S2243E RPP2	LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P05387	Y7	Sugiyama	RPLP2 D11S2243E RPP2	______________MRyVAsyLLAALGGNssPsAKDIKKIL
P05412	T2	GPS6\|SIGNOR\|EPSD\|PSP	JUN	___________________MtAKMETtFYDDALNASFLPSE
P05412	T286	GPS6\|SIGNOR\|EPSD\|PSP	JUN	ASKCRKRKLERIARLEEKVKtLKAQNSELASTANMLREQVA
P05412	T8	GPS6\|SIGNOR\|EPSD\|PSP	JUN	_____________MtAKMETtFYDDALNASFLPSESGPYGY
P05412	T89	GPS6\|SIGNOR\|EPSD\|PSP	JUN	LKLAsPELERLIIQSSNGHItttPtPtQFLCPKNVTDEQEG
P05412	T93	GPS6\|SIGNOR\|EPSD\|PSP	JUN	sPELERLIIQSSNGHItttPtPtQFLCPKNVTDEQEGFAEG
P05783	S305	Sugiyama	KRT18 CYK18 PIG46	QSAEVGAAETTLTELRRtVQsLEIDLDsMRNLKAsLENsLR
P05783	S93	Sugiyama	KRT18 CYK18 PIG46	GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P05787	S104	Sugiyama	KRT8 CYK8	IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787	S280	Sugiyama	KRT8 CYK8	IAEVKAQyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDL
P05787	S330	Sugiyama	KRT8 CYK8	MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P06733	S37	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06748	T279	Sugiyama	NPM1 NPM	GsLPKVEAKFINyVKNCFRMtDQEAIQDLWQWRKsL_____
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07355	S184	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07602	S29	Sugiyama	PSAP GLBA SAP1	SLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVKHCL
P07711	S301	Sugiyama	CTSL CTSL1	VGYGFESTESDNNKYWLVKNsWGEEWGMGGyVKMAKDRRNH
P07737	S57	Sugiyama	PFN1	GKtFVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDs
P07737	S58	Sugiyama	PFN1	KtFVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsL
P07737	S72	Sugiyama	PFN1	VGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFsMDLRtKs
P07737	S77	Sugiyama	PFN1	ssFyVNGLtLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAP
P07814	T1506	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	LCELQPGAKCVCGKNPAKyytLFGRsy______________
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S391	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900	S505	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	KENQKHIyyItGETKDQVANsAFVERLRKHGLEVIyMIEPI
P07900	S63	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900	T317	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08195	S403	Sugiyama	SLC3A2 MDU1	SDLQQILSLLESNKDLLLtssyLsDsGstGEHtKSLVTQYL
P08238	S206	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	KEDQtEyLEERRVKEVVKKHsQFIGyPItLyLEKEREKEIs
P08238	S383	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238	S460	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S497	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08238	S58	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238	T214	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	EERRVKEVVKKHsQFIGyPItLyLEKEREKEIsDDEAEEEK
P08238	T309	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08670	S26	SIGNOR\|ELM\|iPTMNet\|EPSD	VIM	VssssYRRMFGGPGtAsRPsssRsYVttsTRtYsLGsALRP
P08670	S325	Sugiyama	VIM	NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P08670	S39	SIGNOR\|ELM\|iPTMNet\|EPSD	VIM	GtAsRPsssRsYVttsTRtYsLGsALRPstsRsLyAssPGG
P08670	S51	ELM\|iPTMNet\|EPSD	VIM	VttsTRtYsLGsALRPstsRsLyAssPGGVyAtRssAVRLR
P08670	S56	ELM	VIM	RtYsLGsALRPstsRsLyAssPGGVyAtRssAVRLRssVPG
P08670	S66	SIGNOR\|ELM\|iPTMNet\|EPSD	VIM	PstsRsLyAssPGGVyAtRssAVRLRssVPGVRLLQDsVDF
P08670	S73	SIGNOR\|ELM\|iPTMNet\|EPSD	VIM	yAssPGGVyAtRssAVRLRssVPGVRLLQDsVDFsLADAIN
P08729	S104	Sugiyama	KRT7 SCL	LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P08758	T8	Sugiyama	ANXA5 ANX5 ENX2 PP4	_____________MAQVLRGtVtDFPGFDERADAEtLRKAM
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09429	S15	Sugiyama	HMGB1 HMG1	______MGKGDPKKPRGKMssyAFFVQtCREEHKKKHPDAs
P09972	S45	Sugiyama	ALDOC ALDC	APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P0CG38	T789	Sugiyama	POTEI	YPMEHGIITNWDDMEKIWHHtFyNELRVAPEEHPILLTEAP
P0CG39	T752	Sugiyama	POTEJ	YPMEHGIITNWDDMEKIWHHtFyNELRVAPEEHPILLTEAP
P10412	S36	Sugiyama	H1-4 H1F4 HIST1H1E	EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10412	S41	Sugiyama	H1-4 H1F4 HIST1H1E	KKKARKsAGAAKRKAsGPPVsELItKAVAASKERsGVsLAA
P10809	S488	Sugiyama	HSPD1 HSP60	IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P11142	S362	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	RIPKIQKLLQDFFNGKELNKsINPDEAVAyGAAVQAAILsG
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142	T38	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11142	Y41	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11413	S106	Sugiyama	G6PD	PFFKATPEEKLKLEDFFARNsyVAGQyDDAAsyQRLNsHMN
P12035	S211	Sugiyama	KRT3	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12814	S404	Sugiyama	ACTN1	NEIRRLERLDHLAEKFRQKAsIHEAWtDGKEAMLRQKDyEt
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639	S578	Sugiyama	EEF2 EF2	LKDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNK
P13639	S732	Sugiyama	EEF2 EF2	DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13639	T582	Sugiyama	EEF2 EF2	EEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRL
P13639	Y579	Sugiyama	EEF2 EF2	KDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKH
P13647	S181	Sugiyama	KRT5	IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13674	T529	Sugiyama	P4HA1 P4HA	NKWVSNKWLHERGQEFRRPCtLSELE_______________
P13798	S27	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	LsEPEEAAALyRGLSRQPALsAACLGPEVtTQyGGQyRTVH
P13861	S58	Sugiyama	PRKAR2A PKR2 PRKAR2	TRLREARAPAsVLPAAtPRQsLGHPPPEPGPDRVADAKGDs
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618	T45	Sugiyama	PKM OIP3 PK2 PK3 PKM2	TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14618	T50	Sugiyama	PKM OIP3 PK2 PK3 PKM2	MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P14625	S514	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14649	S87	Sugiyama	MYL6B MLC1SA	EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK
P14866	S539	Sugiyama	HNRNPL HNRPL P/OKcl.14	EICDELGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETL
P14866	S542	Sugiyama	HNRNPL HNRPL P/OKcl.14	DELGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFL
P14866	S543	Sugiyama	HNRNPL HNRPL P/OKcl.14	ELGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLN
P14866	S544	Sugiyama	HNRNPL HNRPL P/OKcl.14	LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P14868	S32	Sugiyama	DARS1 DARS PIG40	EKPREIMDAAEDyAKERyGIssMIQsQEKPDRVLVRVRDLt
P14868	S33	Sugiyama	DARS1 DARS PIG40	KPREIMDAAEDyAKERyGIssMIQsQEKPDRVLVRVRDLtI
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15328	S149	Sugiyama	FOLR1 FOLR	VLNVPLCKEDCEQWWEDCRTsYTCKSNWHKGWNWTSGFNKC
P16402	S37	Sugiyama	H1-3 H1F3 HIST1H1D	KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16402	S42	Sugiyama	H1-3 H1F3 HIST1H1D	KKAKKAGATAGKRKAsGPPVsELItKAVAASKERsGVsLAA
P16403	S36	Sugiyama	H1-2 H1F2 HIST1H1C	EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P16403	S41	Sugiyama	H1-2 H1F2 HIST1H1C	KKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsGVsLAA
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17544	S44	Sugiyama	ATF7 ATFA	LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17600	S605	ELM	SYN1	QQRQGPPQKPPGPAGPTRQAsQAGPVPRTGPPTTQQPRPSG
P17600	S9	SIGNOR\|iPTMNet\|EPSD	SYN1	____________MNYLRRRLsDSNFMANLPNGYMTDLQRPQ
P17987	S544	Sugiyama	TCP1 CCT1 CCTA	ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P18859	S57	Sugiyama	ATP5PF ATP5A ATP5J ATPM	DPIQKLFVDKIREYKSKRQTsGGPVDAssEyQQELERELFK
P19105	S19	SIGNOR	MYL12A MLCB MRLC3 RLC	__MSSKRTKTKTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20618	S162	Sugiyama	PSMB1 PSC5	DEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLDNQVG
P20810	S366	Sugiyama	CAST	DKDGKPLLPEPEEKPKPRsEsELIDELsEDFDRsECKEKPS
P20810	S411	Sugiyama	CAST	KTEESKAAAPAPVSEAVCRtsMCsIQSAPPEPATLKGTVPD
P21333	S2152	Sugiyama	FLNA FLN FLN1	VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P21333	S2158	Sugiyama	FLNA FLN FLN1	GRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQDMtAQV
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23142	S247	Sugiyama	FBLN1 PP213	CRLGESCINTVGSFRCQRDssCGtGYELTEDNSCKDIDECE
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588	S359	Sugiyama	EIF4B	RstPKEDDSsASTSQSTRAAsIFGGAKPVDtAAREREVEER
P23588	T205	Sugiyama	EIF4B	GRDRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYR
P24534	S141	Sugiyama	EEF1B2 EEF1B EF1B	ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P24844	S20	GPS6\|ELM\|iPTMNet\|EPSD	MYL9 MLC2 MRLC1 MYRL2	_MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P25398	S107	Sugiyama	RPS12	EWVGLCKIDREGKPRKVVGCsCVVVKDYGKESQAKDVIEEy
P25705	S76	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	EERILGADtsVDLEETGRVLsIGDGIARVHGLRNVQAEEMV
P25789	T10	Sugiyama	PSMA4 HC9 PSC9	___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T24	Sugiyama	RPL13 BBC1 OK/SW-cl.46	SRNGMVLKPHFHKDWQRRVAtWFNQPARKIRRRKARQAKAR
P26583	S15	Sugiyama	HMGB2 HMG2	______MGKGDPNKPRGKMssyAFFVQtCREEHKKKHPDss
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27348	S63	Sugiyama	YWHAQ	LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR
P27448	S42	Sugiyama	MARK3 CTAK1 EMK2	GDGRQEVTSRTSRSGARCRNsIAsCADEQPHIGNyRLLKTI
P27708	S1859	Sugiyama	CAD	RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797	S35	Sugiyama	CALR CRTC	AVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssGK
P27797	S40	Sugiyama	CALR CRTC	AVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssGKFyGDE
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27816	S827	Sugiyama	MAP4	VAKtttAAAVAstGPssRsPstLLPKKPTAIKTEGKPAEVK
P27824	S362	Sugiyama	CANX	WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P28340	S1064	Sugiyama	POLD1 POLD	LNALEERFSRLWTQCQRCQGsLHEDVICTSRDCPIFyMRKK
P29401	S473	Sugiyama	TKT	AtEKAVELAANTKGICFIRTsRPENAIIyNNNEDFQVGQAK
P29401	T444	Sugiyama	TKT	DGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAANT
P29692	S44	Sugiyama	EEF1D EF1D	RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692	S60	Sugiyama	EEF1D EF1D	ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P30048	S199	Sugiyama	PRDX3 AOP1	SGLALRGLFIIDPNGVIKHLsVNDLPVGRSVEETLRLVKAF
P30085	S47	Sugiyama	CMPK1 CMK CMPK UCK UMK UMPK	yGytHLSAGELLRDERKNPDsQyGELIEKYIKEGKIVPVEI
P30086	S52	Sugiyama	PEBP1 PBP PEBP	AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086	T167	Sugiyama	PEBP1 PBP PEBP	GKFKVAsFRKKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK
P30086	Y64	Sugiyama	PEBP1 PBP PEBP	tQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREW
P30533	S242	Sugiyama	LRPAP1 A2MRAP	TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31152	S186	GPS6\|EPSD	MAPK4 ERK4 PRKM4	IGDFGLARIVDQHYSHKGYLsEGLVTKWYRsPRLLLSPNNY
P31327	S898	Sugiyama	CPS1	LYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQIS
P31943	S269	Sugiyama	HNRNPH1 HNRPH HNRPH1	YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQsttGH
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31946	S65	Sugiyama	YWHAB	LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P31948	S16	Sugiyama	STIP1	_____MEQVNELKEKGNKALsVGNIDDALQCysEAIKLDPH
P31949	S35	Sugiyama	S100A11 MLN70 S100C	ESLIAVFQKYAGKDGyNytLsKtEFLsFMNTELAAFTKNQK
P32119	S112	Sugiyama	PRDX2 NKEFB TDPX1	KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P33240	S562	Sugiyama	CSTF2	MQVLQLTADQIAMLPPEQRQsILILKEQIQKSTGAP_____
P33316	S120	Sugiyama	DUT	PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33316	S130	Sugiyama	DUT	GGMQLRFARLsEHAtAPTRGsARAAGYDLYSAYDYTIPPME
P33316	T124	Sugiyama	DUT	ARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYSAYDY
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931	T40	Sugiyama	HSPA1L	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P34931	Y43	Sugiyama	HSPA1L	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P34932	S76	Sugiyama	HSPA4 APG2 HSPH2	VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35222	S552	PSP	CTNNB1 CTNNB OK/SW-cl.35 PRO2286	AIPRLVQLLVRAHQDtQRRtsMGGtQQQFVEGVRMEEIVEG
P35240	S518	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	NF2 SCH	FNLIGDSLSFDFKDTDMKRLsMEIEKEKVEYMEKSKHLQEQ
P35269	T154	Sugiyama	GTF2F1 RAP74	AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35908	S191	Sugiyama	KRT2 KRT2A KRT2E	IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578	S87	Sugiyama	RPL4 RPL1	WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578	T84	Sugiyama	RPL4 RPL1	AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P37108	S25	Sugiyama	SRP14	EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837	S13	Sugiyama	TALDO1 TAL TALDO TALDOR	________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38606	S384	Sugiyama	ATP6V1A ATP6A1 ATP6V1A1 VPP2	RLAEMPADSGYPAyLGARLAsFYERAGRVKCLGNPEREGSV
P38646	S148	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	YDDPEVQKDIKNVPFKIVRAsNGDAWVEAHGKLYSPSQIGA
P38646	S212	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	tVPAyFNDsQRQAtKDAGQIsGLNVLRVINEPTAAALAyGL
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39687	S104	Sugiyama	ANP32A C15orf1 LANP MAPM PHAP1	AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P40189	S839	Sugiyama	IL6ST	CsQHEssPDISHFERSKQVssVNEEDFVRLKQQISDHISQS
P40222	S65	Sugiyama	TXLNA TXLN	GPGsSQAPRKPEGAQARTAQsGALRDVSEELSRQLEDILST
P42166	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43034	S152	Sugiyama	PAFAH1B1 LIS1 MDCR MDS PAFAHA	IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43121	S93	Sugiyama	MCAM MUC18	IFRVRQGQGQSEPGEYEQRLsLQDRGAtLALtQVtPQDERI
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243	S195	Sugiyama	MATR3 KIAA0723	RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P43243	S234	Sugiyama	MATR3 KIAA0723	yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013	S299	Sugiyama	MKI67	GLQGETQLLVSRKSRPKsGGsGHAVAEPAsPEQELDQNKGK
P46013	S648	Sugiyama	MKI67	RVSISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLG
P46013	S651	Sugiyama	MKI67	ISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLGAKQ
P46459	S207	Sugiyama	NSF	KAENSSLNLIGKAKTKENRQsIINPDWNFEKMGIGGLDKEF
P46776	S106	Sugiyama	RPL27A	tRVNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKA
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46776	T72	Sugiyama	RPL27A	yFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRVNAAK
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46778	S104	Sugiyama	RPL21	ILAKRINVRIEHIKHSKSRDsFLKRVKENDQKKKEAKEKGt
P46940	S727	Sugiyama	IQGAP1 KIAA0051	WDEPPNFVQNSMQLSREEIQsSIsGVTAAYNREQLWLANEG
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47756	S226	Sugiyama	CAPZB	CsPHIANIGRLVEDMENKIRstLNEIyFGKTKDIVNGLRSV
P47756	T227	Sugiyama	CAPZB	sPHIANIGRLVEDMENKIRstLNEIyFGKTKDIVNGLRSVQ
P48637	S394	Sugiyama	GSS	LyGEEMVQALKQLKDSEERAsyILMEKIEPEPFENCLLRPG
P48668	S176	Sugiyama	KRT6C KRT6E	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49023	S272	EPSD\|PSP	PXN	QQQtRIsAssAtRELDELMAsLsDFKIQGLEQRADGERCWA
P49023	S274	EPSD\|PSP	PXN	QtRIsAssAtRELDELMAsLsDFKIQGLEQRADGERCWAAG
P49327	S519	Sugiyama	FASN FAS	MGTQWRGMGLSLMRLDRFRDsILRsDEAVKPFGLKVSQLLL
P49419	S84	Sugiyama	ALDH7A1 ATQ1	EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49588	S627	Sugiyama	AARS1 AARS	ATHILNFALRSVLGEADQKGsLVAPDRLRFDFTAKGAMSTQ
P49588	S775	Sugiyama	AARS1 AARS	VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P49736	S229	Sugiyama	MCM2 BM28 CCNL1 CDCL1 KIAA0030	sHGHNVFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLP
P50395	S396	Sugiyama	GDI2 RABGDIB	IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50395	T425	Sugiyama	GDI2 RABGDIB	DAttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED
P50991	S51	Sugiyama	CCT4 CCTD SRB	AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116	T610	Sugiyama	FXR2 FMR1L2	RRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLER
P51858	S83	Sugiyama	HDGF HMG1L2	LFPyEEsKEKFGKPNKRKGFsEGLWEIENNPtVKASGYQSs
P52597	S269	Sugiyama	HNRNPF HNRPF	LSDGYGFTTDLFGRDLsyCLsGMyDHRYGDsEFtVQsTTGH
P52732	S39	Sugiyama	KIF11 EG5 KNSL1 TRIP5	IQVVVRCRPFNLAERKAsAHsIVECDPVRKEVSVRTGGLAD
P52907	S123	Sugiyama	CAPZA1	KEAsDPQPEEADGGLKsWREsCDsALRAYVKDHYSNGFCTV
P52948	T870	Sugiyama	NUP98 ADAR2	GRLEAVSRKQGAQFKEyRPEtGsWVFKVSHFSKYGLQDsDE
P53041	S403	Sugiyama	PPP5C PPP5	DLLWSDPQPQNGRSISKRGVsCQFGPDVTKAFLEENNLDyI
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396	S656	Sugiyama	ACLY	IGNTGGMLDNILASKLyRPGsVAyVSRsGGMsNELNNIISR
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652	T39	Sugiyama	HSPA2	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P54652	Y42	Sugiyama	HSPA2	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P54725	Y188	Sugiyama	RAD23A	TEIMSMGYERERVVAALRASyNNPHRAVEYLLTGIPGsPEP
P54750	S345	Sugiyama	PDE1A	EMVLSTDMSGHFQQIKNIRNsLQQPEGIDRAKTMSLILHAA
P55210	S239	SIGNOR\|EPSD\|PSP	CASP7 MCH3	FLFAYSTVPGYYSWRsPGRGsWFVQALCSILEEHGKDLEIM
P55210	S30	SIGNOR\|EPSD\|PSP	CASP7 MCH3	EQGVEDsANEDsVDAKPDRssFVPSLFsKKKKNVTMRsIKT
P55210	T173	SIGNOR\|EPSD\|PSP	CASP7 MCH3	KDGVTPIKDLTAHFRGDRCKtLLEKPKLFFIQACRGTELDD
P55795	S269	Sugiyama	HNRNPH2 FTP3 HNRPH2	YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQstTGH
P57053	S39	Sugiyama	H2BC12L H2BFS H2BS1	VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P57721	T159	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	sQCGsLIGKGGSKIKEIREstGAQVQVAGDMLPNstERAVT
P58876	S39	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174	S106	Sugiyama	TPI1 TPI	DCGAtWVVLGHsERRHVFGEsDELIGQKVAHALAEGLGVIA
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60660	S30	Sugiyama	MYL6	AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	T89	Sugiyama	ACTB	YPIEHGIVTNWDDMEKIWHHtFyNELRVAPEEHPVLLtEAP
P61081	S175	Sugiyama	UBE2M UBC12	NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61254	S31	Sugiyama	RPL26	RsKNRKRHFNAPsHIRRKIMssPLSKELRQKYNVRSMPIRK
P61353	S39	Sugiyama	RPL27	SGRKAVIVKNIDDGtsDRPysHALVAGIDRyPRKVTAAMGK
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981	S64	Sugiyama	YWHAG	LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA
P62072	S48	Sugiyama	TIMM10 TIM10	ACHRKCVPPHYKEAELSKGEsVCLDRCVSKYLDIHERMGKK
P62241	S159	Sugiyama	RPS8 OK/SW-cl.83	KKRSKKIQKKYDERKKNAKIssLLEEQFQQGKLLACIASRP
P62241	S160	Sugiyama	RPS8 OK/SW-cl.83	KRSKKIQKKYDERKKNAKIssLLEEQFQQGKLLACIASRPG
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62269	S96	Sugiyama	RPS18 D6S218E	QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62269	Y95	Sugiyama	RPS18 D6S218E	RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62280	T127	Sugiyama	RPS11	KNMsVHLsPCFRDVQIGDIVtVGECRPLsKTVRFNVLKVTK
P62633	S121	Sugiyama	CNBP RNF163 ZNF9	CGKPGHLARDCDHADEQKCysCGEFGHIQKDCTKVKCYRCG
P62701	T247	Sugiyama	RPS4X CCG2 RPS4 SCAR	VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62753	S235	SIGNOR\|iPTMNet\|EPSD	RPS6 OK/SW-cl.2	KRMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK______
P62753	S236	SIGNOR\|iPTMNet\|EPSD	RPS6 OK/SW-cl.2	RMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK_______
P62753	S240	SIGNOR\|iPTMNet\|EPSD	RPS6 OK/SW-cl.2	AKEKRQEQIAKRRRLssLRAstsKsEssQK___________
P62753	S242	SIGNOR\|iPTMNet\|EPSD	RPS6 OK/SW-cl.2	EKRQEQIAKRRRLssLRAstsKsEssQK_____________
P62805	S48	GPS6\|EPSD\|Sugiyama	H4C1 H4/A H4FA HIST1H4A; H4C2 H4/I H4FI HIST1H4B; H4C3 H4/G H4FG HIST1H4C; H4C4 H4/B H4FB HIST1H4D; H4C5 H4/J H4FJ HIST1H4E; H4C6 H4/C H4FC HIST1H4F; H4C8 H4/H H4FH HIST1H4H; H4C9 H4/M H4FM HIST1H4I; H4C11 H4/E H4FE HIST1H4J; H4C12 H4/D H4FD HIST1H4K; H4C13 H4/K H4FK HIST1H4L; H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A; H4C15 H4/O H4FO HIST2H4B; H4C16 H4-16 HIST4H4	QGItKPAIRRLARRGGVKRIsGLIyEETRGVLKVFLENVIR
P62807	S39	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62906	T9	Sugiyama	RPL10A NEDD6	____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917	S130	Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917	T135	Sugiyama	RPL8	CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942	T22	Sugiyama	FKBP1A FKBP1 FKBP12	GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62979	S123	Sugiyama	RPS27A UBA80 UBCEP1	LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104	S63	Sugiyama	YWHAZ	LLsVAyKNVVGARRssWRVVssIEQKTEGAEKKQQMAREYR
P63220	S31	Sugiyama	RPS21	LYVPRKCSASNRIIGAKDHAsIQMNVAEVDKVTGRFNGQFK
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	T89	Sugiyama	ACTG1 ACTG	YPIEHGIVTNWDDMEKIWHHtFyNELRVAPEEHPVLLtEAP
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809	S102	Sugiyama	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809	S209	Sugiyama	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809	Y99	Sugiyama	YBX1 NSEP1 YB1	DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	T91	Sugiyama	ACTC1 ACTC	yPIEHGIItNWDDMEKIWHHtFyNELRVAPEEHPtLLTEAP
P68104	T432	Sugiyama	EEF1A1 EEF1A EF1A LENG7	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	T91	Sugiyama	ACTA1 ACTA	yPIEHGIItNWDDMEKIWHHtFyNELRVAPEEHPtLLTEAP
P83731	S86	Sugiyama	RPL24	EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731	T83	Sugiyama	RPL24	QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
Q00059	S160	Sugiyama	TFAM TCF6 TCF6L2	RKAMTKKKELTLLGKPKRPRsAYNVyVAERFQEAKGDsPQE
Q00587	S350	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	HyPEMDARQERVEVLPQARAsWEsLDEEWRAPQAGsRtPVP
Q00610	S146	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	AVYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLL
Q00613	S375	Sugiyama	HSF1 HSTF1	TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105	S168	Sugiyama	SET	ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01469	T85	Sugiyama	FABP5	FSCtLGEKFEETTADGRKTQtVCNFTDGALVQHQEWDGKES
Q01546	S196	Sugiyama	KRT76 KRT2B KRT2P	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02543	S123	Sugiyama	RPL18A	AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q02750	S298	SIGNOR	MAP2K1 MEK1 PRKMK1	QVEGDAAEtPPRPRtPGRPLssyGMDsRPPMAIFELLDYIV
Q02790	T278	Sugiyama	FKBP4 FKBP52	sWEMNsEEKLEQSTIVKERGtVYFKEGKYKQALLQYKKIVS
Q02818	S369	Sugiyama	NUCB1 NUC	RFEEELAAREAELNAKAQRLsQETEALGRsQGRLEAQKREL
Q02878	S255	Sugiyama	RPL6 TXREB1	tEKEKYEITEQRKIDQKAVDsQILPKIKAIPQLQGYLRSVF
Q04637	S895	EPSD\|PSP	EIF4G1 EIF4F EIF4G EIF4GI	EERGRLKEELEEARDIARRRsLGNIKFIGELFKLKMLTEAI
Q04695	S28	Sugiyama	KRT17	FTSSSsIKGSSGLGGGsSRTsCRLsGGLGAGsCRLGSAGGL
Q04695	S32	Sugiyama	KRT17	SsIKGSSGLGGGsSRTsCRLsGGLGAGsCRLGSAGGLGSTL
Q04917	S145	Sugiyama	YWHAH YWHA1	KMKGDYYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQM
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q04917	S64	Sugiyama	YWHAH YWHA1	LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA
Q05639	T432	Sugiyama	EEF1A2 EEF1AL STN	VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q05682	S714	EPSD\|PSP	CALD1 CAD CDM	PTKPAASDLPVPAEGVRNIKsMWEKGNVFssPtAAGtPNKE
Q05682	S744	EPSD\|PSP	CALD1 CAD CDM	sPtAAGtPNKEtAGLKVGVSsRINEWLTKtPDGNKsPAPKP
Q06210	S261	Sugiyama	GFPT1 GFAT GFPT	GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q07021	S210	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q12789	S846	Sugiyama	GTF3C1	ISERRTIKQESGRAGVRPsssGsAWEACSEAPSKGSQDGVT
Q12906	S20	Sugiyama	ILF3 DRBF MPHOSPH4 NF90	_MRPMRIFVNDDRHVMAKHssVyPTQEELEAVQNMVsHtER
Q12906	S46	Sugiyama	ILF3 DRBF MPHOSPH4 NF90	EELEAVQNMVsHtERALKAVsDWIDEQEKGssEQAEsDNMD
Q13136	S239	Sugiyama	PPFIA1 LIP1	GVLDINHEQENtPstsGKRssDGsLsHEEDLAKVIELQEII
Q13136	S666	Sugiyama	PPFIA1 LIP1	IQEEKENTEQRAEEIESRVGsGsLDNLGRFRSMssIPPYPA
Q13136	T572	Sugiyama	PPFIA1 LIP1	LRRPQKGRLAALRDEPSKVQtLNEQDWERAQQASVLANVAQ
Q13153	S110	Sugiyama	PAK1	DAVTGEFTGMPEQWARLLQtsNITKsEQKKNPQAVLDVLEF
Q13177	S109	Sugiyama	PAK2	DAVTGEFTGMPEQWARLLQtsNItKLEQKKNPQAVLDVLKF
Q13177	S132	Sugiyama	PAK2	tKLEQKKNPQAVLDVLKFyDsNtVKQKyLsFtPPEKDGFPs
Q13177	S141	SIGNOR\|iPTMNet\|EPSD\|PSP\|Sugiyama	PAK2	QAVLDVLKFyDsNtVKQKyLsFtPPEKDGFPsGtPALNAKG
Q13177	S152	Sugiyama	PAK2	sNtVKQKyLsFtPPEKDGFPsGtPALNAKGtEAPAVVtEEE
Q13177	S19	SIGNOR\|iPTMNet\|EPSD	PAK2	__MsDNGELEDKPPAPPVRMsstIFsTGGKDPLsANHsLKP
Q13177	S192	SIGNOR\|iPTMNet\|EPSD\|PSP\|Sugiyama	PAK2	EDDDEEtAPPVIAPRPDHTKsIytRsVIDPVPAPVGDsHVD
Q13177	S197	SIGNOR\|iPTMNet\|EPSD\|PSP\|Sugiyama	PAK2	EtAPPVIAPRPDHTKsIytRsVIDPVPAPVGDsHVDGAAKs
Q13177	S20	SIGNOR\|iPTMNet\|EPSD\|Sugiyama	PAK2	_MsDNGELEDKPPAPPVRMsstIFsTGGKDPLsANHsLKPL
Q13177	S209	Sugiyama	PAK2	HTKsIytRsVIDPVPAPVGDsHVDGAAKsLDKQKKKTKMTD
Q13177	S55	SIGNOR\|iPTMNet\|EPSD\|Sugiyama	PAK2	HsLKPLPsVPEEKKPRHKIIsIFsGtEKGsKKKEKERPEIs
Q13177	S58	Sugiyama	PAK2	KPLPsVPEEKKPRHKIIsIFsGtEKGsKKKEKERPEIsPPS
Q13177	T154	Sugiyama	PAK2	tVKQKyLsFtPPEKDGFPsGtPALNAKGtEAPAVVtEEEDD
Q13177	T169	Sugiyama	PAK2	GFPsGtPALNAKGtEAPAVVtEEEDDDEEtAPPVIAPRPDH
Q13177	T402	SIGNOR\|iPTMNet\|EPSD\|PSP	PAK2	VKLTDFGFCAQITPEQSKRstMVGTPYWMAPEVVTRKAYGP
Q13177	Y139	Sugiyama	PAK2	NPQAVLDVLKFyDsNtVKQKyLsFtPPEKDGFPsGtPALNA
Q13177	Y194	Sugiyama	PAK2	DDEEtAPPVIAPRPDHTKsIytRsVIDPVPAPVGDsHVDGA
Q13263	S784	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13283	S67	Sugiyama	G3BP1 G3BP	sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13442	T18	Sugiyama	PDAP1 HASPP28	___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13561	S83	Sugiyama	DCTN2 DCTN50	GTKGLDFsDRIGKTKRtGyEsGEyEMLGEGLGVKETPQQKY
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14157	S360	Sugiyama	UBAP2L KIAA0144 NICE4	sMLGKGFGDVGEAKGGsttGsQFLEQFKTAQALAQLAAQHS
Q14247	S322	Sugiyama	CTTN EMS1	ySKGFGGKyGVQKDRMDKNAstFEDVtQVssAyQKTVPVEA
Q14432	T311	Sugiyama	PDE3A	RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14498	S336	Sugiyama	RBM39 HCC1 RNPC2	LAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGR
Q14566	S271	Sugiyama	MCM6	VPDVSKLSTPGARAEtNsRVsGVDGyEtEGIRGLRALGVRD
Q14566	S498	Sugiyama	MCM6	EQQTISITKAGVKATLNARTsILAAANPIsGHyDRSKSLKQ
Q14697	S913	Sugiyama	GANAB G2AN KIAA0088	VIIGAGKPAAVVLQTKGSPEsRLsFQHDPEtsVLVLRKPGI
Q14697	S916	Sugiyama	GANAB G2AN KIAA0088	GAGKPAAVVLQTKGSPEsRLsFQHDPEtsVLVLRKPGINVA
Q14697	T923	Sugiyama	GANAB G2AN KIAA0088	VVLQTKGSPEsRLsFQHDPEtsVLVLRKPGINVASDWSIHL
Q14847	S99	Sugiyama	LASP1 MLN50	ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14980	S1162	Sugiyama	NUMA1 NMP22 NUMA	QADsLERsLEAERASRAERDsALEtLQGQLEEKAQELGHsQ
Q14980	S1991	Sugiyama	NUMA1 NMP22 NUMA	QPIQIAEGTGITTRQQRKRVsLEPHQGPGtPEsKKATSCFP
Q14CN4	S138	Sugiyama	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15021	S585	Sugiyama	NCAPD2 CAPD2 CNAP1 KIAA0159	ILGLIFKGPAASTQEKNPREstGNMVTGQTVCKNKPNMsDP
Q15021	T586	Sugiyama	NCAPD2 CAPD2 CNAP1 KIAA0159	LGLIFKGPAASTQEKNPREstGNMVTGQTVCKNKPNMsDPE
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15185	S85	Sugiyama	PTGES3 P23 TEBP	KHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVDFNN
Q15365	T127	Sugiyama	PCBP1	TQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15366	T127	Sugiyama	PCBP2	sQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15417	S259	Sugiyama	CNN3	DNSTISLQMGTNKVAsQKGMsVyGLGRQVYDPKYCAAPTEP
Q15746	S1208	SIGNOR\|EPSD	MYLK MLCK MLCK1 MYLK1	DDAPASENTKAPEMKSRRPKssLPPVLGTESDATVKKKPAP
Q15746	S1760	SIGNOR\|EPSD	MYLK MLCK MLCK1 MYLK1	MARRKWQKTGNAVRAIGRLssMAMISGLSGRKsstGsPtsP
Q15796	S417	EPSD\|PSP	SMAD2 MADH2 MADR2	SVNQGFEAVYQLTRMCTIRMsFVKGWGAEYRRQTVTSTPCW
Q15796	S464	PSP	SMAD2 MADH2 MADR2	GPLQWLDKVLTQMGsPsVRCssMs_________________
Q15796	S465	PSP	SMAD2 MADH2 MADR2	PLQWLDKVLTQMGsPsVRCssMs__________________
Q15796	S467	PSP	SMAD2 MADH2 MADR2	QWLDKVLTQMGsPsVRCssMs____________________
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16659	S189	GPS6\|EPSD\|PSP	MAPK6 ERK3 PRKM6	IGDFGLARIMDPHYSHKGHLsEGLVTKWYRSPRLLLSPNNY
Q3SY84	S143	Sugiyama	KRT71 K6IRS1 KB34 KRT6IRS1	IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q4G0J3	T257	Sugiyama	LARP7 HDCMA18P	KEENMDtsNtsIsKMKRsRPtsEGsDIEstEPQKQCSKKKK
Q53QZ3	S292	PSP	ARHGAP15 BM-024 BM-030 BM-046	GLIKDQIFGSHLHKVCERENsTVPWFVKQCIEAVEKRGLDV
Q53QZ3	S4	PSP	ARHGAP15 BM-024 BM-030 BM-046	_________________MQKstNsDtSVETLNSTRQGTGAV
Q53QZ3	S41	PSP	ARHGAP15 BM-024 BM-030 BM-046	TGAVQMRIKNANSHHDRLsQsKsMILTDVGKVTEPISRHRR
Q53QZ3	S43	PSP	ARHGAP15 BM-024 BM-030 BM-046	AVQMRIKNANSHHDRLsQsKsMILTDVGKVTEPISRHRRNH
Q58FF6	S34	Sugiyama	HSP90AB4P	IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7	S185	Sugiyama	HSP90AB3P HSP90BC	KEDQtEyLEERRVKEVVKKHsQFIGyPItLyLEKEQDKEIs
Q58FF7	S370	Sugiyama	HSP90AB3P HSP90BC	KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q58FF7	S58	Sugiyama	HSP90AB3P HSP90BC	IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF7	T193	Sugiyama	HSP90AB3P HSP90BC	EERRVKEVVKKHsQFIGyPItLyLEKEQDKEIsDDEAEEEK
Q58FF8	S58	Sugiyama	HSP90AB2P HSP90BB	IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5BKZ1	Y93	Sugiyama	ZNF326 ZIRD	PYESyDsRsSLGGRDLYRsGyGFNEPEQSRFGGSYGGRFES
Q5JTD0	S361	Sugiyama	TJAP1 PILT TJP4	IPRNsPLPNCtyAtRQAISLsLVEEGSERARPSPVPSTPAS
Q5QNW6	S39	Sugiyama	H2BC18 HIST2H2BF	VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5T0N5	S488	Sugiyama	FNBP1L C1orf39 TOCA1	NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD
Q5T1M5	S1162	Sugiyama	FKBP15 KIAA0674	EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5T4S7	S3846	Sugiyama	UBR4 KIAA0462 KIAA1307 RBAF600	KELLEYDLQQREAATKSSRTsVQPTFTASQyRALsVLGCGH
Q5T5C0	S692	Sugiyama	STXBP5 LLGL3	YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q5TAX3	S1383	Sugiyama	TUT4 KIAA0191 ZCCHC11	GDAGHVRRECPEVKLARQRNssVAAAQLVRNLVNAQQVAGS
Q5TBB1	S191	Sugiyama	RNASEH2B DLEU8	VNQTVAALKTNNVNVSSRVQsTAFFSGDQASTDKEEDYIRY
Q5VT52	S1070	Sugiyama	RPRD2 KIAA0460 HSPC099	TATDQQQQEEHYRIETRVsssCLDLPDSTEEKGAPIETLGy
Q5VTE0	T432	Sugiyama	EEF1A1P5 EEF1AL3	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5XKE5	S155	Sugiyama	KRT79 K6L KB38 KRT6L	IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6IBS0	S139	Sugiyama	TWF2 PTK9L MSTP011	DELFGTVKDDLSFAGyQKHLssCAAPAPLtsAERELQQIRI
Q6S8J3	T789	Sugiyama	POTEE A26C1A POTE2	YPMEHGIITNWDDMEKIWHHtFyNELRVAPEEHPILLTEAP
Q6UVK1	S1857	Sugiyama	CSPG4 MCSP	ASVPLRLTRGSRAPISRAQLsVVDPDSAPGEIEyEVQRAPH
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZN18	S206	Sugiyama	AEBP2	DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q70Z35	S1107	SIGNOR\|EPSD\|PSP	PREX2 DEPDC2	FNVAGDEQEDSGHDTISNRDsYSDCNSNRNSIASFTSICSS
Q7KZF4	S150	Sugiyama	SND1 TDRD11	EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS
Q7RTS7	S153	Sugiyama	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z417	T685	Sugiyama	NUFIP2 KIAA1321 PIG1	HTKEMEsIWNLQKQDPKRIItyNEAMDsPDQ__________
Q7Z5L9	S240	Sugiyama	IRF2BP2	AAASLGSAQPTDLGAHKRPAsVsssAAVEHEQREAAAKEKQ
Q7Z5L9	S457	Sugiyama	IRF2BP2	GSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVGGQ
Q7Z794	S177	Sugiyama	KRT77 KRT1B	IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86V48	S703	Sugiyama	LUZP1	EPKPQPNsREKAKTRGAPRTsLFENDKDAGMENESVKSVRA
Q86V48	S957	Sugiyama	LUZP1	PTRIGKNVESTNSNAytQRsstDFsELEQPRSCLFEQGTRR
Q86V48	S961	Sugiyama	LUZP1	GKNVESTNSNAytQRsstDFsELEQPRSCLFEQGTRRVGPS
Q86V81	S239	Sugiyama	ALYREF ALY BEF THOC4	tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46	S145	Sugiyama	KRT73 K6IRS3 KB36 KRT6IRS3	IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8	S904	Sugiyama	CHERP DAN26 SCAF6	KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IYU2	S385	EPSD\|PSP	HACE1 KIAA1320	HSLDEWLVLIATELMKNKRDstEITSILLKQKGQDQDAASI
Q8IZ21	S117	Sugiyama	PHACTR4 PRO2963	KPSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIP
Q8N201	S495	Sugiyama	INTS1 KIAA1440 UNQ1821/PRO3434	KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N6T3	T292	Sugiyama	ARFGAP1 ARF1GAP	VsQLAsKVQGVGSKGWRDVttFFsGKAEGPLDsPSEGHSyQ
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8ND56	S368	Sugiyama	LSM14A C19orf13 FAM61A RAP55 RAP55A	EGNADEEDPLGPNCYYDKTKsFFDNIsCDDNRERRPtWAEE
Q8TD47	T247	Sugiyama	RPS4Y2 RPS4Y2P	VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8TDZ2	S817	PSP	MICAL1 MICAL NICAL	DPSQPTRRQIRLSsPERQRLssLNLTPDPEMEPPPKPPRSC
Q8TDZ2	S960	PSP	MICAL1 MICAL NICAL	AALRELEAEGVKLELALRRQsSSPEQQKKLWVGQLLQLVDK
Q8TEW0	S386	Sugiyama	PARD3 PAR3 PAR3A	YEQLSQSEKNNyyssRFsPDsQyIDNRSVNSAGLHTVQRAP
Q8TEW0	S720	Sugiyama	PARD3 PAR3 PAR3A	ELPIETALDDRERRIsHsLysGIEGLDEsPsRNAALsRIMG
Q8TEW0	S962	Sugiyama	PARD3 PAR3 PAR3A	DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ
Q92734	S183	Sugiyama	TFG	AsMsAFDPLKNQDEINKNVMsAFGLtDDQVsGPPsAPAEDR
Q92797	S13	Sugiyama	SYMPK SPK	________MASGSGDSVTRRsVAsQFFtQEEGPGIDGMTTS
Q92797	S16	Sugiyama	SYMPK SPK	_____MASGSGDSVTRRsVAsQFFtQEEGPGIDGMTTSERV
Q93079	S39	Sugiyama	H2BC9 H2BFJ HIST1H2BH	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q969S3	S38	Sugiyama	ZNF622 ZPR9	MQRAHYKTDWHRYNLRRKVAsMAPVTAEGFQERVRAQRAVA
Q96CT7	S122	Sugiyama	CCDC124	DtLRRDHQLREAPDTAEKAKsHLEVPLEENVNRRVLEEGsV
Q96D15	S117	Sugiyama	RCN3 UNQ239/PRO272	VsLAELRAWIAHTQQRHIRDsVsAAWDtyDtDRDGRVGWEE
Q96D46	S462	Sugiyama	NMD3 CGI-07	FLEDLEEDEAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAE
Q96G46	T240	Sugiyama	DUS3L	KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96HC4	S85	Sugiyama	PDLIM5 ENH L9	EAQNKIKGCTGsLNMtLQRAsAAPKPEPVPVQKGEPKEVVK
Q96IZ0	S242	Sugiyama	PAWR PAR4	VSGRyKsttsVsEEDVsSRYsRTDRSGFPRYNRDANVsGtL
Q96JP5	S85	Sugiyama	ZFP91 ZNF757 FKSG11	AAAVSRRRKAEYPRRRRssPsARPPDVPGQQPQAAKsPsPV
Q96P16	S285	Sugiyama	RPRD1A P15RS	YKRKLARVSLVRKELRSRIQsLPDLSRLPNVTGSHMHLPFA
Q96RS6	S373	Sugiyama	NUDCD1 CML66	EGLTWPELVIGDKQGELIRDsAQCAAIAERLMHLtsEELNP
Q96RU3	S497	Sugiyama	FNBP1 FBP17 KIAA0554	AWLAEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREs
Q96ST2	S561	Sugiyama	IWS1 IWS1L	GKRRRNRDGGtFIsDADDVVsAMIVKMNEAAEEDRQLNNQK
Q96ST2	T551	Sugiyama	IWS1 IWS1L	MMLQRKKSMSGKRRRNRDGGtFIsDADDVVsAMIVKMNEAA
Q99523	S793	GPS6\|SIGNOR\|PSP	SORT1	AGVLIVKKYVCGGRFLVHRysVLQQHAEANGVDGVDALDtA
Q99523	S825	GPS6	SORT1	DGVDALDtAsHtNKsGYHDDsDEDLLE______________
Q99613	S865	Sugiyama	EIF3C EIF3S8	HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99832	S59	Sugiyama	CCT7 CCTH NIP7-1	TLGPRGMDKLIVDGRGKAtIsNDGAtILKLLDVVHPAAKTL
Q99877	S39	Sugiyama	H2BC15 H2BFD HIST1H2BN	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879	S39	Sugiyama	H2BC14 H2BFE HIST1H2BM	INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880	S39	Sugiyama	H2BC13 H2BFC HIST1H2BL	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQK8	S262	Sugiyama	LPIN3 LIPN3L	SHMQWAWGRLPKVARAERPEsSVVLEGRAGATSPPRGGPST
Q9BS26	T398	Sugiyama	ERP44 KIAA0573 TXNDC4 UNQ532/PRO1075	VASSPPESSFQKLAPsEyRytLLRDRDEL____________
Q9BTC0	S988	Sugiyama	DIDO1 C20orf158 DATF1 KIAA0333	PRTAPSSsCTAVASAASRPDsTHMVEARQDVPKPVLTSVMV
Q9BUB5	S39	SIGNOR\|iPTMNet\|EPSD	MKNK1 MNK1	LPIADGDRRRKKKRRGRATDsLPGKFEDMYKLTSELLGEGA
Q9BX68	S57	Sugiyama	HINT2	GNEVAKAQQAtPGGAAPtIFsRILDKsLPADILyEDQQCLV
Q9BY44	S526	Sugiyama	EIF2A CDA02 MSTP004 MSTP089	sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BYX7	T89	Sugiyama	POTEKP ACTBL3 FKSG30	YPMEHGIITNWDDMEKIWHHtFyNELRVAPEEHPILLTEAP
Q9C0C2	S1616	Sugiyama	TNKS1BP1 KIAA1741 TAB182	LSEAADsDAHLFQDSTEPRAsRVPssDEEVVEEPQsRRTRM
Q9C0C2	S429	Sugiyama	TNKS1BP1 KIAA1741 TAB182	EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9C0C2	S983	Sugiyama	TNKS1BP1 KIAA1741 TAB182	sGGsSRtLDAQDRsFGtRPLssGFsPEEAQQQDEEFEKKIP
Q9GZT3	S15	Sugiyama	SLIRP C14orf156 DC23 DC50 PD04872	______MAASAARGAAALRRsINQPVAFVRRIPWTAASSQL
Q9H0B6	S428	Sugiyama	KLC2	NKPIWMHAEEREESKDKRRDsAPyGEyGsWYKACKVDsPtV
Q9H0L4	S601	Sugiyama	CSTF2T KIAA0689	MQVLQLTADQIAMLPPEQRQsILILKEQIQKSTGAS_____
Q9H2G2	S340	Sugiyama	SLK KIAA0204 STK2	EEDEEEEtENsLPIPAsKRAssDLsIAssEEDKLsQNACIL
Q9H4I2	S658	Sugiyama	ZHX3 KIAA0395 TIX1	LDEELDRLRSEtKMTRREIDsWFSERRKKVNAEETKKAEEN
Q9H5V8	S288	Sugiyama	CDCP1 TRASK UNQ2486/PRO5773	NFNLSNCERKEERVEYyIPGstTNPEVFKLEDKQPGNMAGN
Q9H5V8	T289	Sugiyama	CDCP1 TRASK UNQ2486/PRO5773	FNLSNCERKEERVEYyIPGstTNPEVFKLEDKQPGNMAGNF
Q9H5V8	Y284	Sugiyama	CDCP1 TRASK UNQ2486/PRO5773	VSFLNFNLSNCERKEERVEYyIPGstTNPEVFKLEDKQPGN
Q9H788	S315	Sugiyama	SH2D4A PPP1R38 SH2A	LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H788	Y131	Sugiyama	SH2D4A PPP1R38 SH2A	EEPRKTHsEEFTNsLKTKsQyHDLQAPDNQQtKDIWKKVAE
Q9H7D7	S121	Sugiyama	WDR26 CDW2 MIP2 PRO0852	ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9NQP4	S125	Sugiyama	PFDN4 PFD4	VEsIQRVLADLKVQLYAKFGsNINLEADEs___________
Q9NRY5	S209	Sugiyama	FAM114A2 C5orf3	AEGDPGFKRTKGLMNRNATLsQVLREAKEKEEIRTSNEVTV
Q9NSB2	S178	Sugiyama	KRT84 KRTHB4	AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NWM8	S140	Sugiyama	FKBP14 FKBP22 UNQ322/PRO381	PPESTLIFNIDLLEIRNGPRsHESFQEMDLNDDWKLSKDEV
Q9NYF8	S319	Sugiyama	BCLAF1 BTF KIAA0164	RsPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKR
Q9NYF8	S320	Sugiyama	BCLAF1 BTF KIAA0164	sPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRF
Q9NYV4	S1053	Sugiyama	CDK12 CRK7 CRKRS KIAA0904	LPHWQDCHELWSKKRRRQRQsGVVVEEPPPSKTSRKETtsG
Q9NZB2	S990	Sugiyama	FAM120A C9orf10 KIAA0183 OSSA	FPLQVVSVGGPARGRPRGVIstPVIRTFGRGGRYYGRGYKN
Q9NZL9	S9	Sugiyama	MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995	____________MVGREKELsIHFVPGsCRLVEEEVNIPNR
Q9P265	S258	Sugiyama	DIP2B KIAA1463	ANIDLPPSGIVKGMHKGsNRssLMDTADGVPVSSRVSTKIQ
Q9P287	S12	Sugiyama	BCCIP TOK1	_________MASRSKRRAVEsGVPQPPDPPVQRDEEEEKEV
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UIQ6	S51	Sugiyama	LNPEP OTASE	AKEPCLHPLEPDEVEyEPRGsRLLVRGLGEHEMEEDEEDyE
Q9ULD2	S1259	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	LCsPKRsPtssAIPLQsPRNsGsFPsPsIsPR_________
Q9ULX3	S390	Sugiyama	NOB1 ART4 NOB1P PSMD8BP1 MSTP158	VsPFVENDISSRSATLQVRDsTLGAGRRRLNPNASRKKFVK
Q9UNF1	S264	Sugiyama	MAGED2 BCG1	sLRsPKARRGKARRRAAKLQssQEPEAPPPRDVALLQGRAN
Q9UNX3	S31	Sugiyama	RPL26L1 RPL26P1	RsKNRKRHFNAPSHVRRKIMssPLSKELRQKYNVRSMPIRK
Q9UNZ2	S176	Sugiyama	NSFL1C UBXN2C	RLGAAPEEEsAyVAGEKRQHssQDVHVVLKLWKsGFsLDNG
Q9UNZ2	S74	Sugiyama	NSFL1C UBXN2C	SQATPssVsRGTAPSDNRVtsFRDLIHDQDEDEEEEEGQRF
Q9UNZ2	T73	Sugiyama	NSFL1C UBXN2C	ISQATPssVsRGTAPSDNRVtsFRDLIHDQDEDEEEEEGQR
Q9UPQ0	S177	Sugiyama	LIMCH1 KIAA1102	LAQMRKDTDDIEsPKRSIRDsGyIDCWDsERsDsLsPPRHG
Q9UPQ0	S377	Sugiyama	LIMCH1 KIAA1102	LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ80	S335	Sugiyama	PA2G4 EBP1	FVAQFKFTVLLMPNGPMRITsGPFEPDLyKsEMEVQDAELK
Q9Y230	Y430	Sugiyama	RUVBL2 INO80J TIP48 TIP49B CGI-46	SLVCRKRKGtEVQVDDIKRVysLFLDEsRSTQYMKEyQDAF
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y383	S176	Sugiyama	LUC7L2 CGI-59 CGI-74	MDEVEKARAKKREAEEVyRNsMPASsFQQQKLRVCEVCSAY
Q9Y3U8	S91	Sugiyama	RPL36	KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y5K6	S458	Sugiyama	CD2AP	ETEPVSKLKLDsEQLPLRPKsVDFDsLtVRtsKEtDVVNFD
Q9Y5M8	S257	Sugiyama	SRPRB PSEC0230	LPLKVEFLECSAKGGRGDVGsADIQDLEKWLAKIA______
Q9Y608	S18	Sugiyama	LRRFIP2	___MGTPASGRKRTPVKDRFsAEDEALsNIAREAEARLAAK
Q9Y6X8	S575	Sugiyama	ZHX2 AFR1 KIAA0854 RAF	TQAELDRLRVETKLSRREIDsWFSERRKLRDSMEQAVLDSM

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Signal Transduction	R-HSA-162582	5.186785e-10	9.285	1	0
Cell Cycle	R-HSA-1640170	1.046028e-08	7.980	0	0
Cell Cycle Checkpoints	R-HSA-69620	2.851481e-08	7.545	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.599721e-07	6.585	0	0
Cell Cycle, Mitotic	R-HSA-69278	4.945036e-07	6.306	0	0
Apoptotic execution phase	R-HSA-75153	5.154614e-07	6.288	1	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	9.799032e-07	6.009	0	0
NRAGE signals death through JNK	R-HSA-193648	3.238707e-06	5.490	0	0
Meiotic synapsis	R-HSA-1221632	4.269410e-06	5.370	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.417631e-06	5.266	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	5.339112e-06	5.273	0	0
Axon guidance	R-HSA-422475	6.079124e-06	5.216	1	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	6.725030e-06	5.172	0	0
Diseases of programmed cell death	R-HSA-9645723	7.043375e-06	5.152	0	0
Nervous system development	R-HSA-9675108	7.354036e-06	5.133	1	0
G alpha (12/13) signalling events	R-HSA-416482	1.130646e-05	4.947	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.318783e-05	4.880	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.573380e-05	4.803	0	0
Meiosis	R-HSA-1500620	1.920661e-05	4.717	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.219833e-05	4.654	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	2.542943e-05	4.595	0	0
G2/M DNA damage checkpoint	R-HSA-69473	3.138025e-05	4.503	0	0
Cellular Senescence	R-HSA-2559583	3.465651e-05	4.460	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.026624e-05	4.395	0	0
Chromatin modifying enzymes	R-HSA-3247509	4.610854e-05	4.336	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.769665e-05	4.322	0	0
G2/M Checkpoints	R-HSA-69481	5.698100e-05	4.244	0	0
DNA methylation	R-HSA-5334118	6.232006e-05	4.205	0	0
M Phase	R-HSA-68886	7.516496e-05	4.124	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.920599e-05	4.050	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.043432e-04	3.982	0	0
Chromatin organization	R-HSA-4839726	1.245792e-04	3.905	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	1.415653e-04	3.849	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.415508e-04	3.849	0	0
Apoptosis	R-HSA-109581	1.546460e-04	3.811	1	0
p75 NTR receptor-mediated signalling	R-HSA-193704	1.708751e-04	3.767	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.738147e-04	3.760	0	0
PRC2 methylates histones and DNA	R-HSA-212300	2.066947e-04	3.685	0	0
Death Receptor Signaling	R-HSA-73887	2.075408e-04	3.683	0	0
Reproduction	R-HSA-1474165	2.015031e-04	3.696	0	0
Rap1 signalling	R-HSA-392517	2.232883e-04	3.651	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.582832e-04	3.588	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.140526e-04	3.503	1	1
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.361539e-04	3.473	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.361539e-04	3.473	0	0
Packaging Of Telomere Ends	R-HSA-171306	3.653268e-04	3.437	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	3.522528e-04	3.453	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.595430e-04	3.444	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	3.653268e-04	3.437	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	3.595430e-04	3.444	0	0
Signaling by Hippo	R-HSA-2028269	4.011143e-04	3.397	0	0
Regulation of TP53 Activity	R-HSA-5633007	4.190093e-04	3.378	0	0
EPH-Ephrin signaling	R-HSA-2682334	4.787524e-04	3.320	1	0
Defective pyroptosis	R-HSA-9710421	5.165849e-04	3.287	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	5.564841e-04	3.255	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.512617e-04	3.259	0	0
Amplification of signal from the kinetochores	R-HSA-141424	6.322752e-04	3.199	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	6.322752e-04	3.199	0	0
Programmed Cell Death	R-HSA-5357801	6.158665e-04	3.211	1	0
Cell junction organization	R-HSA-446728	6.279409e-04	3.202	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	6.248951e-04	3.204	0	0
HATs acetylate histones	R-HSA-3214847	7.434621e-04	3.129	0	0
Signaling by ROBO receptors	R-HSA-376176	7.837410e-04	3.106	1	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	8.329486e-04	3.079	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	8.541525e-04	3.068	0	0
Mitotic Prometaphase	R-HSA-68877	8.652375e-04	3.063	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	9.532814e-04	3.021	0	0
Meiotic recombination	R-HSA-912446	1.068491e-03	2.971	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.039082e-03	2.983	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.130320e-03	2.947	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.120782e-03	2.950	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	1.119436e-03	2.951	0	0
Assembly of the pre-replicative complex	R-HSA-68867	1.143521e-03	2.942	0	0
Oncogenic MAPK signaling	R-HSA-6802957	1.146021e-03	2.941	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.151033e-03	2.939	0	0
Signaling by VEGF	R-HSA-194138	1.269455e-03	2.896	1	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.277509e-03	2.894	0	0
Cell-Cell communication	R-HSA-1500931	1.289453e-03	2.890	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.310286e-03	2.883	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	1.322077e-03	2.879	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.386696e-03	2.858	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.472497e-03	2.832	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.472497e-03	2.832	0	0
DNA Double Strand Break Response	R-HSA-5693606	1.474608e-03	2.831	0	0
Activation of RAC1	R-HSA-428540	1.604304e-03	2.795	1	1
mRNA Splicing	R-HSA-72172	1.572537e-03	2.803	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.627035e-03	2.789	0	0
RNA Polymerase II Transcription	R-HSA-73857	1.704716e-03	2.768	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	1.812994e-03	2.742	0	0
PKMTs methylate histone lysines	R-HSA-3214841	1.812994e-03	2.742	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.842162e-03	2.735	0	0
Nucleosome assembly	R-HSA-774815	1.976583e-03	2.704	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.976583e-03	2.704	0	0
Sema4D in semaphorin signaling	R-HSA-400685	1.980128e-03	2.703	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.040825e-03	2.690	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.187394e-03	2.660	0	0
Mitotic Prophase	R-HSA-68875	2.156906e-03	2.666	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	2.067562e-03	2.685	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.379289e-03	2.624	0	0
Interleukin-37 signaling	R-HSA-9008059	2.389721e-03	2.622	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.741396e-03	2.562	0	0
MTOR signalling	R-HSA-165159	2.693422e-03	2.570	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.637402e-03	2.579	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	2.693422e-03	2.570	0	0
Depyrimidination	R-HSA-73928	2.693422e-03	2.570	0	0
Signaling by WNT	R-HSA-195721	2.876952e-03	2.541	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	2.922511e-03	2.534	0	0
Gene expression (Transcription)	R-HSA-74160	2.947544e-03	2.531	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	3.025447e-03	2.519	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	3.069509e-03	2.513	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	3.127498e-03	2.505	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	3.127498e-03	2.505	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.257343e-03	2.487	0	0
Intracellular signaling by second messengers	R-HSA-9006925	3.409371e-03	2.467	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.939490e-03	2.405	0	0
Generic Transcription Pathway	R-HSA-212436	4.105546e-03	2.387	0	0
RET signaling	R-HSA-8853659	4.135611e-03	2.383	0	0
Cell-cell junction organization	R-HSA-421270	4.325328e-03	2.364	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.354183e-03	2.361	0	0
Neurodegenerative Diseases	R-HSA-8863678	4.446289e-03	2.352	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	4.446289e-03	2.352	0	0
HDACs deacetylate histones	R-HSA-3214815	4.893434e-03	2.310	0	0
MAPK family signaling cascades	R-HSA-5683057	4.661403e-03	2.331	1	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	4.927920e-03	2.307	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.931729e-03	2.307	0	0
Adherens junctions interactions	R-HSA-418990	4.984782e-03	2.302	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	5.024558e-03	2.299	0	0
Cleavage of the damaged purine	R-HSA-110331	5.024558e-03	2.299	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.523447e-03	2.258	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.523447e-03	2.258	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	5.523447e-03	2.258	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	5.500949e-03	2.260	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.262809e-03	2.279	0	0
DNA Replication Pre-Initiation	R-HSA-69002	5.500949e-03	2.260	0	0
Signaling by RAS mutants	R-HSA-6802949	5.523447e-03	2.258	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	5.359491e-03	2.271	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	5.359491e-03	2.271	0	0
Separation of Sister Chromatids	R-HSA-2467813	5.531614e-03	2.257	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	5.578615e-03	2.253	0	0
Depurination	R-HSA-73927	6.061483e-03	2.217	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.114673e-03	2.214	0	0
Mitotic G2-G2/M phases	R-HSA-453274	6.619505e-03	2.179	0	0
Mitotic Anaphase	R-HSA-68882	6.635062e-03	2.178	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	6.637341e-03	2.178	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	7.141061e-03	2.146	0	0
Semaphorin interactions	R-HSA-373755	7.602191e-03	2.119	1	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	8.298163e-03	2.081	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	9.137051e-03	2.039	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	9.261486e-03	2.033	0	0
Homology Directed Repair	R-HSA-5693538	9.642991e-03	2.016	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	9.914082e-03	2.004	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.023076e-02	1.990	1	1
RAF/MAP kinase cascade	R-HSA-5673001	1.105980e-02	1.956	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.117456e-02	1.952	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.117456e-02	1.952	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.117456e-02	1.952	0	0
Muscle contraction	R-HSA-397014	1.154272e-02	1.938	1	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.184615e-02	1.926	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.186605e-02	1.926	0	0
Post NMDA receptor activation events	R-HSA-438064	1.235982e-02	1.908	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	1.385816e-02	1.858	0	0
DARPP-32 events	R-HSA-180024	1.300151e-02	1.886	0	0
Epigenetic regulation of gene expression	R-HSA-212165	1.362570e-02	1.866	0	0
G2/M Transition	R-HSA-69275	1.371340e-02	1.863	0	0
Estrogen-dependent gene expression	R-HSA-9018519	1.390332e-02	1.857	0	0
Protein-protein interactions at synapses	R-HSA-6794362	1.608713e-02	1.794	0	0
RAF activation	R-HSA-5673000	1.616410e-02	1.791	0	0
Co-stimulation by CD28	R-HSA-389356	1.619619e-02	1.791	1	0
MAPK1/MAPK3 signaling	R-HSA-5684996	1.659751e-02	1.780	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.666481e-02	1.778	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.666481e-02	1.778	0	0
FOXO-mediated transcription	R-HSA-9614085	1.688679e-02	1.772	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	1.855331e-02	1.732	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	1.855331e-02	1.732	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.858731e-02	1.731	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.972292e-02	1.705	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.972292e-02	1.705	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.972292e-02	1.705	0	0
Ephrin signaling	R-HSA-3928664	1.858731e-02	1.731	1	1
EPHB-mediated forward signaling	R-HSA-3928662	1.894313e-02	1.723	0	0
Kinesins	R-HSA-983189	1.996473e-02	1.700	0	0
Ub-specific processing proteases	R-HSA-5689880	1.912540e-02	1.718	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.816181e-02	1.741	0	0
Cell-extracellular matrix interactions	R-HSA-446353	2.035795e-02	1.691	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	2.047402e-02	1.689	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	2.066702e-02	1.685	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	2.154566e-02	1.667	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	2.160144e-02	1.666	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.163952e-02	1.665	0	0
PIP3 activates AKT signaling	R-HSA-1257604	2.198070e-02	1.658	0	0
FLT3 Signaling	R-HSA-9607240	2.217413e-02	1.654	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.240874e-02	1.650	0	0
Membrane Trafficking	R-HSA-199991	2.248618e-02	1.648	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	2.309256e-02	1.637	0	0
Germ layer formation at gastrulation	R-HSA-9754189	2.317475e-02	1.635	0	0
Developmental Biology	R-HSA-1266738	2.425857e-02	1.615	1	0
S Phase	R-HSA-69242	2.449239e-02	1.611	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.838341e-02	1.547	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	2.838341e-02	1.547	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	2.838341e-02	1.547	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.838341e-02	1.547	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.597893e-02	1.585	0	0
Signaling by RAF1 mutants	R-HSA-9656223	2.558775e-02	1.592	0	0
mRNA 3'-end processing	R-HSA-72187	2.751393e-02	1.560	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	2.590674e-02	1.587	0	0
Neurexins and neuroligins	R-HSA-6794361	2.751393e-02	1.560	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.838341e-02	1.547	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.597893e-02	1.585	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.838341e-02	1.547	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.937304e-02	1.532	0	0
GP1b-IX-V activation signalling	R-HSA-430116	2.973777e-02	1.527	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.973777e-02	1.527	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.990492e-02	1.524	1	1
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	3.005614e-02	1.522	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	3.339496e-02	1.476	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	3.339496e-02	1.476	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	3.339496e-02	1.476	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	3.457510e-02	1.461	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.575868e-02	1.447	0	0
Activation of BH3-only proteins	R-HSA-114452	3.575868e-02	1.447	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	3.634474e-02	1.440	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	3.674162e-02	1.435	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.965976e-02	1.402	0	0
Specification of primordial germ cells	R-HSA-9827857	3.991445e-02	1.399	0	0
Regulation of KIT signaling	R-HSA-1433559	4.564254e-02	1.341	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	4.157804e-02	1.381	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.097073e-02	1.388	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.513772e-02	1.345	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	4.370024e-02	1.360	0	0
TRP channels	R-HSA-3295583	4.201176e-02	1.377	0	0
Regulation of TP53 Degradation	R-HSA-6804757	4.673329e-02	1.330	0	0
Calmodulin induced events	R-HSA-111933	4.673329e-02	1.330	0	0
DAG and IP3 signaling	R-HSA-1489509	4.315264e-02	1.365	0	0
CaM pathway	R-HSA-111997	4.673329e-02	1.330	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	4.407477e-02	1.356	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	4.816917e-02	1.317	0	0
Interleukin-1 family signaling	R-HSA-446652	4.842840e-02	1.315	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	4.847277e-02	1.315	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	4.847277e-02	1.315	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	4.847277e-02	1.315	0	0
Polo-like kinase mediated events	R-HSA-156711	4.847277e-02	1.315	0	0
mTORC1-mediated signalling	R-HSA-166208	4.939873e-02	1.306	0	0
Deubiquitination	R-HSA-5688426	4.950403e-02	1.305	0	0
Hedgehog 'off' state	R-HSA-5610787	5.026829e-02	1.299	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	5.095201e-02	1.293	0	0
MAP2K and MAPK activation	R-HSA-5674135	5.098638e-02	1.293	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	5.163099e-02	1.287	0	0
Chromosome Maintenance	R-HSA-73886	5.176321e-02	1.286	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	5.506108e-02	1.259	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	5.506108e-02	1.259	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	5.583354e-02	1.253	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	5.583354e-02	1.253	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	5.630838e-02	1.249	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	5.630838e-02	1.249	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	5.811426e-02	1.236	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	5.534071e-02	1.257	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.747146e-02	1.241	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	6.281195e-02	1.202	0	0
Regulation of endogenous retroelements	R-HSA-9842860	5.866148e-02	1.232	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	5.534071e-02	1.257	0	0
Dopamine receptors	R-HSA-390651	5.506108e-02	1.259	0	0
Activation of ATR in response to replication stress	R-HSA-176187	5.534071e-02	1.257	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.630838e-02	1.249	0	0
Rab regulation of trafficking	R-HSA-9007101	5.941778e-02	1.226	0	0
Smooth Muscle Contraction	R-HSA-445355	5.747146e-02	1.241	1	1
Syndecan interactions	R-HSA-3000170	5.811416e-02	1.236	0	0
Regulation of PTEN localization	R-HSA-8948747	5.583354e-02	1.253	0	0
Amyloid fiber formation	R-HSA-977225	5.563174e-02	1.255	0	0
Striated Muscle Contraction	R-HSA-390522	6.318078e-02	1.199	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.347187e-02	1.197	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	6.361700e-02	1.196	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	6.490037e-02	1.188	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	6.490037e-02	1.188	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	6.490037e-02	1.188	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	6.490037e-02	1.188	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	6.571552e-02	1.182	0	0
Regulation of gene expression in beta cells	R-HSA-210745	6.571552e-02	1.182	0	0
AURKA Activation by TPX2	R-HSA-8854518	6.790462e-02	1.168	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	6.855695e-02	1.164	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	6.855695e-02	1.164	0	0
Breakdown of the nuclear lamina	R-HSA-352238	6.855695e-02	1.164	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	6.885860e-02	1.162	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.885860e-02	1.162	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.885860e-02	1.162	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.885860e-02	1.162	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.885860e-02	1.162	0	0
Formation of definitive endoderm	R-HSA-9823730	6.885860e-02	1.162	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	6.938957e-02	1.159	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	6.994137e-02	1.155	1	0
Netrin-1 signaling	R-HSA-373752	7.202263e-02	1.143	0	0
G1/S Transition	R-HSA-69206	7.249779e-02	1.140	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	7.259765e-02	1.139	0	0
Type I hemidesmosome assembly	R-HSA-446107	7.345028e-02	1.134	0	0
Adrenoceptors	R-HSA-390696	7.345028e-02	1.134	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	7.362770e-02	1.133	0	0
Cellular responses to stimuli	R-HSA-8953897	7.428599e-02	1.129	0	0
DNA Replication	R-HSA-69306	7.440201e-02	1.128	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	7.903190e-02	1.102	0	0
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	7.903190e-02	1.102	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	7.903190e-02	1.102	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	8.022828e-02	1.096	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	8.022828e-02	1.096	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	8.022828e-02	1.096	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	8.022828e-02	1.096	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	8.022828e-02	1.096	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	8.071277e-02	1.093	0	0
HDMs demethylate histones	R-HSA-3214842	7.829672e-02	1.106	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	7.517292e-02	1.124	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	7.560594e-02	1.121	0	0
Centrosome maturation	R-HSA-380287	8.911604e-02	1.050	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	8.694874e-02	1.061	0	0
Long-term potentiation	R-HSA-9620244	7.829672e-02	1.106	0	0
Protein ubiquitination	R-HSA-8852135	8.911604e-02	1.050	0	0
Regulation of CDH1 Function	R-HSA-9764561	8.524527e-02	1.069	0	0
NrCAM interactions	R-HSA-447038	7.903190e-02	1.102	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	8.962946e-02	1.048	0	0
Signaling by ALK in cancer	R-HSA-9700206	8.962946e-02	1.048	0	0
MITF-M-dependent gene expression	R-HSA-9856651	8.900277e-02	1.051	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	9.073642e-02	1.042	1	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.113336e-01	0.953	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	1.113336e-01	0.953	0	0
Regulation of TP53 Expression	R-HSA-6804754	1.113336e-01	0.953	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.113336e-01	0.953	0	0
C6 deamination of adenosine	R-HSA-75102	1.113336e-01	0.953	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.113336e-01	0.953	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.113336e-01	0.953	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.113336e-01	0.953	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.113336e-01	0.953	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.113336e-01	0.953	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.113336e-01	0.953	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.113336e-01	0.953	0	0
Potassium transport channels	R-HSA-1296067	1.113336e-01	0.953	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.113336e-01	0.953	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.113336e-01	0.953	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	1.067271e-01	0.972	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.067271e-01	0.972	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	9.353447e-02	1.029	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	9.353447e-02	1.029	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	9.353447e-02	1.029	0	0
ALK mutants bind TKIs	R-HSA-9700645	9.353447e-02	1.029	0	0
Formation of apoptosome	R-HSA-111458	1.159169e-01	0.936	0	0
Regulation of the apoptosome activity	R-HSA-9627069	1.159169e-01	0.936	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.159169e-01	0.936	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	9.730929e-02	1.012	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	9.730929e-02	1.012	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	9.730929e-02	1.012	0	0
PKA activation	R-HSA-163615	1.126487e-01	0.948	0	0
PKA activation in glucagon signalling	R-HSA-164378	1.126487e-01	0.948	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.021754e-01	0.991	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	1.021754e-01	0.991	0	0
Integrin signaling	R-HSA-354192	1.082988e-01	0.965	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.489888e-02	1.023	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.576162e-02	1.019	0	0
Cellular response to heat stress	R-HSA-3371556	1.128662e-01	0.947	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.401305e-02	1.027	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.126487e-01	0.948	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.077161e-01	0.968	0	0
Telomere Maintenance	R-HSA-157579	9.657484e-02	1.015	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.021754e-01	0.991	0	0
Eukaryotic Translation Elongation	R-HSA-156842	9.682355e-02	1.014	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.004793e-01	0.998	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	9.576162e-02	1.019	0	0
Apoptotic factor-mediated response	R-HSA-111471	1.126487e-01	0.948	0	0
Regulation of CDH11 function	R-HSA-9762292	1.159169e-01	0.936	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	9.730929e-02	1.012	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	9.730929e-02	1.012	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	9.321591e-02	1.031	0	0
Cardiogenesis	R-HSA-9733709	1.082988e-01	0.965	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	9.367120e-02	1.028	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	9.730929e-02	1.012	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	1.026832e-01	0.989	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.120352e-01	0.951	0	0
Neuronal System	R-HSA-112316	1.104754e-01	0.957	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	9.730929e-02	1.012	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	1.077161e-01	0.968	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.082988e-01	0.965	0	0
RNA Polymerase I Transcription	R-HSA-73864	1.121142e-01	0.950	0	0
Ca-dependent events	R-HSA-111996	1.050639e-01	0.979	0	0
Unwinding of DNA	R-HSA-176974	9.353447e-02	1.029	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	1.126487e-01	0.948	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	9.367120e-02	1.028	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	9.641623e-02	1.016	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.107172e-01	0.956	0	0
Signaling by NOTCH	R-HSA-157118	1.058150e-01	0.975	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.160660e-01	0.935	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.160660e-01	0.935	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	1.160660e-01	0.935	0	0
Base Excision Repair	R-HSA-73884	1.193517e-01	0.923	0	0
PLC beta mediated events	R-HSA-112043	1.203112e-01	0.920	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.207596e-01	0.918	0	0
L1CAM interactions	R-HSA-373760	1.209907e-01	0.917	0	0
ESR-mediated signaling	R-HSA-8939211	1.218833e-01	0.914	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.246689e-01	0.904	0	0
RMTs methylate histone arginines	R-HSA-3214858	1.272178e-01	0.895	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.274768e-01	0.895	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	1.274768e-01	0.895	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.284585e-01	0.891	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.292709e-01	0.888	0	0
Ion homeostasis	R-HSA-5578775	1.298055e-01	0.887	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.298055e-01	0.887	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.298725e-01	0.886	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.302106e-01	0.885	0	0
Drug resistance of KIT mutants	R-HSA-9669937	1.322950e-01	0.878	0	0
Drug resistance of PDGFR mutants	R-HSA-9674415	1.322950e-01	0.878	0	0
KIT mutants bind TKIs	R-HSA-9669921	1.322950e-01	0.878	0	0
PDGFR mutants bind TKIs	R-HSA-9674428	1.322950e-01	0.878	0	0
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.322950e-01	0.878	0	0
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.322950e-01	0.878	0	0
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.322950e-01	0.878	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.322950e-01	0.878	0	0
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.322950e-01	0.878	0	0
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.322950e-01	0.878	0	0
Imatinib-resistant KIT mutants	R-HSA-9669917	1.322950e-01	0.878	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.322950e-01	0.878	0	0
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.322950e-01	0.878	0	0
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.322950e-01	0.878	0	0
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.322950e-01	0.878	0	0
Masitinib-resistant KIT mutants	R-HSA-9669924	1.322950e-01	0.878	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.322950e-01	0.878	0	0
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.322950e-01	0.878	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.322950e-01	0.878	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.590965e-01	0.798	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.590965e-01	0.798	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.710660e-01	0.767	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	1.710660e-01	0.767	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	1.710660e-01	0.767	0	0
SOS-mediated signalling	R-HSA-112412	1.710660e-01	0.767	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	1.710660e-01	0.767	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.710660e-01	0.767	0	0
Signaling by APC mutants	R-HSA-4839744	1.403852e-01	0.853	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.403852e-01	0.853	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.403852e-01	0.853	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.403852e-01	0.853	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.666960e-01	0.778	0	0
DCC mediated attractive signaling	R-HSA-418885	1.363952e-01	0.865	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.363952e-01	0.865	1	1
Activation of BAD and translocation to mitochondria	R-HSA-111447	1.363952e-01	0.865	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.581723e-01	0.801	0	0
Phosphorylation of the APC/C	R-HSA-176412	1.581723e-01	0.801	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.581723e-01	0.801	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.485723e-01	0.828	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	1.560241e-01	0.807	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	1.560241e-01	0.807	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.560241e-01	0.807	0	0
Activation of the pre-replicative complex	R-HSA-68962	1.447017e-01	0.840	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.342677e-01	0.872	0	0
Trafficking of AMPA receptors	R-HSA-399719	1.605529e-01	0.794	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.372965e-01	0.862	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	1.771745e-01	0.752	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.644632e-01	0.784	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.644632e-01	0.784	0	0
HSF1-dependent transactivation	R-HSA-3371571	1.402345e-01	0.853	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.405704e-01	0.852	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.405704e-01	0.852	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.645353e-01	0.784	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.359200e-01	0.867	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.755825e-01	0.756	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.733269e-01	0.761	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.733269e-01	0.761	0	0
Prolonged ERK activation events	R-HSA-169893	1.581723e-01	0.801	0	0
MHC class II antigen presentation	R-HSA-2132295	1.757726e-01	0.755	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	1.682457e-01	0.774	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.757726e-01	0.755	0	0
p75NTR signals via NF-kB	R-HSA-193639	1.363952e-01	0.865	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.406460e-01	0.852	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.710660e-01	0.767	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.386582e-01	0.858	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.342677e-01	0.872	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	1.710660e-01	0.767	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	1.644632e-01	0.784	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	1.644632e-01	0.784	0	0
Opioid Signalling	R-HSA-111885	1.495427e-01	0.825	0	0
Autophagy	R-HSA-9612973	1.644439e-01	0.784	0	0
Cellular responses to stress	R-HSA-2262752	1.521945e-01	0.818	0	0
Metabolism of RNA	R-HSA-8953854	1.518725e-01	0.819	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	1.710660e-01	0.767	0	0
Signaling by AXIN mutants	R-HSA-4839735	1.666960e-01	0.778	0	0
Signaling by AMER1 mutants	R-HSA-4839748	1.666960e-01	0.778	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	1.430267e-01	0.845	0	0
Glycolysis	R-HSA-70171	1.699970e-01	0.770	0	0
Formation of the nephric duct	R-HSA-9830364	1.560241e-01	0.807	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.393696e-01	0.856	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.521319e-01	0.818	0	0
Signaling by Interleukins	R-HSA-449147	1.475144e-01	0.831	1	0
Interleukin-7 signaling	R-HSA-1266695	1.560241e-01	0.807	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.363952e-01	0.865	0	0
Sensory processing of sound	R-HSA-9659379	1.810660e-01	0.742	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	1.812562e-01	0.742	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.831142e-01	0.737	0	0
Switching of origins to a post-replicative state	R-HSA-69052	1.837130e-01	0.736	0	0
G-protein mediated events	R-HSA-112040	1.862514e-01	0.730	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.926250e-01	0.715	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.926250e-01	0.715	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.926250e-01	0.715	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.928573e-01	0.715	0	0
Signaling by SCF-KIT	R-HSA-1433557	1.940083e-01	0.712	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.945174e-01	0.711	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.945174e-01	0.711	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.945174e-01	0.711	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	1.945174e-01	0.711	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.945174e-01	0.711	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	1.945174e-01	0.711	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.945863e-01	0.711	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.945863e-01	0.711	0	0
p75NTR recruits signalling complexes	R-HSA-209543	1.945863e-01	0.711	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	1.945863e-01	0.711	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	1.947400e-01	0.711	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.470946e-01	0.607	1	1
Diseases of Telomere Maintenance	R-HSA-9673013	2.470946e-01	0.607	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.470946e-01	0.607	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.470946e-01	0.607	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.470946e-01	0.607	0	0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	R-HSA-5619043	2.470946e-01	0.607	0	0
Defective SLC26A4 causes Pendred syndrome (PDS)	R-HSA-5619046	2.470946e-01	0.607	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.470946e-01	0.607	0	0
Regulation of gap junction activity	R-HSA-191650	2.097789e-01	0.678	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.097789e-01	0.678	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.097789e-01	0.678	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	2.097789e-01	0.678	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.097789e-01	0.678	0	0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	2.097789e-01	0.678	0	0
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	2.097789e-01	0.678	0	0
PI and PC transport between ER and Golgi membranes	R-HSA-1483196	3.467117e-01	0.460	0	0
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	3.467117e-01	0.460	0	0
Mitochondrial transcription initiation	R-HSA-163282	3.467117e-01	0.460	0	0
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	3.467117e-01	0.460	0	0
Intestinal infectious diseases	R-HSA-8942233	3.467117e-01	0.460	0	0
Signaling by kinase domain mutants of KIT	R-HSA-9669933	3.467117e-01	0.460	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.467117e-01	0.460	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.467117e-01	0.460	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	3.467117e-01	0.460	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.467117e-01	0.460	0	0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	3.467117e-01	0.460	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.467117e-01	0.460	0	0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.467117e-01	0.460	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	3.467117e-01	0.460	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.467117e-01	0.460	0	0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.467117e-01	0.460	0	0
MyD88 deficiency (TLR5)	R-HSA-5602680	3.467117e-01	0.460	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	3.467117e-01	0.460	0	0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.467117e-01	0.460	0	0
IRS activation	R-HSA-74713	2.617733e-01	0.582	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.617733e-01	0.582	0	0
G2 Phase	R-HSA-68911	2.617733e-01	0.582	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	2.065471e-01	0.685	0	0
Formation of annular gap junctions	R-HSA-196025	2.065471e-01	0.685	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	2.065471e-01	0.685	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.065471e-01	0.685	0	0
ARMS-mediated activation	R-HSA-170984	2.434837e-01	0.614	0	0
Lipophagy	R-HSA-9613354	2.434837e-01	0.614	0	0
Gap junction degradation	R-HSA-190873	2.434837e-01	0.614	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.138461e-01	0.503	0	0
Phosphorylation of Emi1	R-HSA-176417	3.138461e-01	0.503	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	4.331534e-01	0.363	1	1
Regulation of cortical dendrite branching	R-HSA-8985801	4.331534e-01	0.363	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	4.331534e-01	0.363	0	0
Interaction between PHLDA1 and AURKA	R-HSA-8854521	4.331534e-01	0.363	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.331534e-01	0.363	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	4.331534e-01	0.363	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	4.331534e-01	0.363	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.331534e-01	0.363	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.331534e-01	0.363	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	4.331534e-01	0.363	0	0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	4.331534e-01	0.363	0	0
Formation of axial mesoderm	R-HSA-9796292	2.237833e-01	0.650	0	0
Folding of actin by CCT/TriC	R-HSA-390450	2.813559e-01	0.551	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	3.650670e-01	0.438	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.650670e-01	0.438	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.650670e-01	0.438	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	2.307205e-01	0.637	0	0
Notch-HLH transcription pathway	R-HSA-350054	2.105521e-01	0.677	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	3.196914e-01	0.495	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.196914e-01	0.495	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.850045e-01	0.545	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.850045e-01	0.545	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.850045e-01	0.545	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.125275e-01	0.673	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.327663e-01	0.633	0	0
Co-inhibition by CTLA4	R-HSA-389513	2.834815e-01	0.547	0	0
Differentiation of T cells	R-HSA-9945266	3.165008e-01	0.500	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	3.165008e-01	0.500	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	3.165008e-01	0.500	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	3.165008e-01	0.500	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	3.580706e-01	0.446	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	4.147501e-01	0.382	0	0
Netrin mediated repulsion signals	R-HSA-418886	4.147501e-01	0.382	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	4.147501e-01	0.382	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	4.147501e-01	0.382	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	4.147501e-01	0.382	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.147501e-01	0.382	0	0
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	5.081617e-01	0.294	0	0
Classical Kir channels	R-HSA-1296053	5.081617e-01	0.294	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.081617e-01	0.294	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.081617e-01	0.294	0	0
Invadopodia formation	R-HSA-8941237	5.081617e-01	0.294	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	5.081617e-01	0.294	0	0
Defective GCLC causes HAGGSD	R-HSA-5578999	5.081617e-01	0.294	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.114353e-01	0.675	0	0
Tight junction interactions	R-HSA-420029	2.798000e-01	0.553	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	3.482574e-01	0.458	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	3.482574e-01	0.458	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.482574e-01	0.458	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.482574e-01	0.458	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	3.482574e-01	0.458	0	0
G1/S-Specific Transcription	R-HSA-69205	2.699625e-01	0.569	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	2.646018e-01	0.577	0	0
Orc1 removal from chromatin	R-HSA-68949	2.378716e-01	0.624	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.114694e-01	0.675	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	3.284938e-01	0.483	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	3.284938e-01	0.483	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	3.800482e-01	0.420	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.800482e-01	0.420	0	0
Regulation by c-FLIP	R-HSA-3371378	4.624059e-01	0.335	0	0
Dimerization of procaspase-8	R-HSA-69416	4.624059e-01	0.335	0	0
Activation of RAS in B cells	R-HSA-1169092	4.624059e-01	0.335	0	0
FGFR1b ligand binding and activation	R-HSA-190370	4.624059e-01	0.335	0	0
Translation initiation complex formation	R-HSA-72649	2.700466e-01	0.569	0	0
HIV elongation arrest and recovery	R-HSA-167287	3.532562e-01	0.452	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	3.532562e-01	0.452	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.335540e-01	0.363	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.335540e-01	0.363	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.234627e-01	0.651	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.417404e-01	0.466	0	0
Regulation of RAS by GAPs	R-HSA-5658442	3.121332e-01	0.506	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	3.035039e-01	0.518	0	0
Late endosomal microautophagy	R-HSA-9615710	3.781489e-01	0.422	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	3.520637e-01	0.453	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	2.540980e-01	0.595	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	3.407615e-01	0.468	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.653472e-01	0.576	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.030677e-01	0.395	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	4.429278e-01	0.354	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.429278e-01	0.354	0	0
WNT mediated activation of DVL	R-HSA-201688	5.077012e-01	0.294	0	0
CASP8 activity is inhibited	R-HSA-5218900	5.077012e-01	0.294	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	5.732482e-01	0.242	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	5.732482e-01	0.242	0	0
ATP sensitive Potassium channels	R-HSA-1296025	5.732482e-01	0.242	0	0
Defective MAT1A causes MATD	R-HSA-5579024	5.732482e-01	0.242	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	5.732482e-01	0.242	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.732482e-01	0.242	0	0
snRNP Assembly	R-HSA-191859	3.554380e-01	0.449	0	0
Metabolism of non-coding RNA	R-HSA-194441	3.554380e-01	0.449	0	0
EGFR downregulation	R-HSA-182971	4.279134e-01	0.369	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	3.492918e-01	0.457	0	0
Voltage gated Potassium channels	R-HSA-1296072	4.328082e-01	0.364	0	0
Spry regulation of FGF signaling	R-HSA-1295596	5.055159e-01	0.296	0	0
Erythropoietin activates RAS	R-HSA-9027284	5.055159e-01	0.296	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.055159e-01	0.296	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	4.233547e-01	0.373	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.037433e-01	0.298	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	5.037433e-01	0.298	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	5.504263e-01	0.259	0	0
2-LTR circle formation	R-HSA-164843	5.504263e-01	0.259	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	5.504263e-01	0.259	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	4.215722e-01	0.375	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.023118e-01	0.299	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	4.249593e-01	0.372	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	4.785095e-01	0.320	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	4.785095e-01	0.320	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	5.396732e-01	0.268	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	5.396732e-01	0.268	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	5.000923e-01	0.301	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	4.991917e-01	0.302	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	5.330339e-01	0.273	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	5.330339e-01	0.273	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.283619e-01	0.277	0	0
Telomere Extension By Telomerase	R-HSA-171319	5.283619e-01	0.277	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.283619e-01	0.277	0	0
Formation of the Early Elongation Complex	R-HSA-113418	5.283619e-01	0.277	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	5.283619e-01	0.277	0	0
Neutrophil degranulation	R-HSA-6798695	4.111478e-01	0.386	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	5.366125e-01	0.270	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	5.480379e-01	0.261	0	0
Signaling by Erythropoietin	R-HSA-9006335	5.537887e-01	0.257	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.537887e-01	0.257	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.724312e-01	0.242	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.724312e-01	0.242	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	5.904682e-01	0.229	0	0
Viral mRNA Translation	R-HSA-192823	5.510744e-01	0.259	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	5.618095e-01	0.250	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	5.707401e-01	0.244	0	0
HSF1 activation	R-HSA-3371511	5.707401e-01	0.244	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	5.707401e-01	0.244	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	5.785237e-01	0.238	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	5.785237e-01	0.238	0	0
Interleukin receptor SHC signaling	R-HSA-912526	5.888724e-01	0.230	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	5.888724e-01	0.230	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.862296e-01	0.543	0	0
RNA Polymerase III Transcription	R-HSA-74158	5.707401e-01	0.244	0	0
Developmental Cell Lineages	R-HSA-9734767	5.315621e-01	0.274	0	0
Regulation of necroptotic cell death	R-HSA-5675482	4.770210e-01	0.321	0	0
Signaling by ERBB2	R-HSA-1227986	3.730623e-01	0.428	0	0
G-protein beta:gamma signalling	R-HSA-397795	3.192347e-01	0.496	0	0
HIV Transcription Elongation	R-HSA-167169	3.520637e-01	0.453	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.256797e-01	0.647	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	5.785237e-01	0.238	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	2.813559e-01	0.551	0	0
Signaling by PDGFR in disease	R-HSA-9671555	3.382118e-01	0.471	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	2.834815e-01	0.547	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	5.339077e-01	0.273	0	0
mRNA Editing	R-HSA-75072	2.434837e-01	0.614	0	0
G0 and Early G1	R-HSA-1538133	2.969985e-01	0.527	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.030677e-01	0.395	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	4.757183e-01	0.323	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.196222e-01	0.284	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.380932e-01	0.623	0	0
Regulation of mitotic cell cycle	R-HSA-453276	2.380932e-01	0.623	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	3.520637e-01	0.453	0	0
Aggrephagy	R-HSA-9646399	3.520637e-01	0.453	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	3.185311e-01	0.497	0	0
Recycling pathway of L1	R-HSA-437239	2.591805e-01	0.586	0	0
Frs2-mediated activation	R-HSA-170968	2.237833e-01	0.650	0	0
Resolution of D-Loop Structures	R-HSA-5693537	2.125275e-01	0.673	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	5.553219e-01	0.255	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	5.533905e-01	0.257	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.434837e-01	0.614	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	2.286765e-01	0.641	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	4.116667e-01	0.385	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.379446e-01	0.471	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	3.603840e-01	0.443	0	0
TNF signaling	R-HSA-75893	2.045957e-01	0.689	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.246152e-01	0.649	0	0
Interleukin-1 signaling	R-HSA-9020702	3.303112e-01	0.481	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	4.486731e-01	0.348	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.097789e-01	0.678	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	2.434837e-01	0.614	0	0
Formation of lateral plate mesoderm	R-HSA-9758920	3.138461e-01	0.503	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.138461e-01	0.503	0	0
Processing of SMDT1	R-HSA-8949664	2.237833e-01	0.650	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	2.813559e-01	0.551	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	2.813559e-01	0.551	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	2.054929e-01	0.687	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.147501e-01	0.382	0	0
Nuclear RNA decay	R-HSA-9930044	3.192347e-01	0.496	0	0
Peptide chain elongation	R-HSA-156902	2.234627e-01	0.651	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	3.311474e-01	0.480	0	0
Eukaryotic Translation Termination	R-HSA-72764	3.395423e-01	0.469	0	0
PI3K/AKT activation	R-HSA-198203	5.504263e-01	0.259	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	5.396732e-01	0.268	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.396732e-01	0.268	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	5.614378e-01	0.251	0	0
PCP/CE pathway	R-HSA-4086400	5.618095e-01	0.250	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	4.030677e-01	0.395	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	5.039758e-01	0.298	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.311465e-01	0.636	0	0
Ca2+ pathway	R-HSA-4086398	4.796193e-01	0.319	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.505807e-01	0.346	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	5.330339e-01	0.273	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.097789e-01	0.678	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	2.617733e-01	0.582	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.065471e-01	0.685	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	2.434837e-01	0.614	0	0
cGMP effects	R-HSA-418457	2.540125e-01	0.595	0	0
NF-kB is activated and signals survival	R-HSA-209560	3.580706e-01	0.446	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.624059e-01	0.335	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	4.429278e-01	0.354	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	5.077012e-01	0.294	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	4.100429e-01	0.387	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	3.780314e-01	0.422	0	0
COPI-mediated anterograde transport	R-HSA-6807878	4.507315e-01	0.346	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	2.076969e-01	0.683	0	0
Mitophagy	R-HSA-5205647	5.248114e-01	0.280	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.614378e-01	0.251	0	0
Interleukin-2 signaling	R-HSA-9020558	5.904682e-01	0.229	0	0
Regulated Necrosis	R-HSA-5218859	3.949437e-01	0.403	0	0
Stabilization of p53	R-HSA-69541	4.778983e-01	0.321	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	3.482574e-01	0.458	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.039708e-01	0.517	0	0
Cap-dependent Translation Initiation	R-HSA-72737	3.889234e-01	0.410	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	2.065471e-01	0.685	0	0
Signal attenuation	R-HSA-74749	2.813559e-01	0.551	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	2.813559e-01	0.551	0	0
Repression of WNT target genes	R-HSA-4641265	3.961286e-01	0.402	0	0
Eukaryotic Translation Initiation	R-HSA-72613	3.889234e-01	0.410	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	5.339077e-01	0.273	0	0
Integration of energy metabolism	R-HSA-163685	3.387920e-01	0.470	0	0
G1 Phase	R-HSA-69236	4.576240e-01	0.339	0	0
Cyclin D associated events in G1	R-HSA-69231	4.576240e-01	0.339	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	5.396732e-01	0.268	0	0
Selective autophagy	R-HSA-9663891	2.234627e-01	0.651	0	0
Signaling by NOTCH1	R-HSA-1980143	2.202559e-01	0.657	0	0
Cellular response to chemical stress	R-HSA-9711123	5.758810e-01	0.240	0	0
Signalling to ERKs	R-HSA-187687	2.503129e-01	0.602	0	0
Signaling by WNT in cancer	R-HSA-4791275	2.969985e-01	0.527	0	0
Signaling by Hedgehog	R-HSA-5358351	2.215799e-01	0.654	0	0
TCR signaling	R-HSA-202403	3.733746e-01	0.428	1	0
Sensory perception of sour taste	R-HSA-9729555	2.097789e-01	0.678	0	0
Calcineurin activates NFAT	R-HSA-2025928	2.434837e-01	0.614	0	0
Transcription from mitochondrial promoters	R-HSA-75944	4.331534e-01	0.363	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.650670e-01	0.438	0	0
Abacavir transmembrane transport	R-HSA-2161517	3.650670e-01	0.438	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	2.125275e-01	0.673	0	0
Ca2+ activated K+ channels	R-HSA-1296052	4.147501e-01	0.382	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	2.311465e-01	0.636	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	4.624059e-01	0.335	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	4.624059e-01	0.335	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.192347e-01	0.496	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	2.663226e-01	0.575	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.653472e-01	0.576	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	5.077012e-01	0.294	0	0
Cardiac conduction	R-HSA-5576891	2.726666e-01	0.564	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.730623e-01	0.428	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.730623e-01	0.428	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.730623e-01	0.428	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.730623e-01	0.428	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	5.055159e-01	0.296	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	5.037433e-01	0.298	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	5.504263e-01	0.259	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	5.011176e-01	0.300	0	0
Formation of the posterior neural plate	R-HSA-9832991	5.904682e-01	0.229	0	0
Signaling by FGFR in disease	R-HSA-1226099	4.963652e-01	0.304	0	0
Triglyceride catabolism	R-HSA-163560	5.707401e-01	0.244	0	0
DAP12 signaling	R-HSA-2424491	5.785237e-01	0.238	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.011176e-01	0.300	0	0
Signaling by EGFR	R-HSA-177929	2.045957e-01	0.689	0	0
Macroautophagy	R-HSA-1632852	2.502431e-01	0.602	0	0
Synthesis of DNA	R-HSA-69239	5.215667e-01	0.283	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	3.961286e-01	0.402	0	0
Transmission across Chemical Synapses	R-HSA-112315	4.432093e-01	0.353	0	0
Hedgehog 'on' state	R-HSA-5632684	2.380932e-01	0.623	0	0
Cilium Assembly	R-HSA-5617833	4.995494e-01	0.301	0	0
Vesicle-mediated transport	R-HSA-5653656	5.371882e-01	0.270	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	2.097789e-01	0.678	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.617733e-01	0.582	0	0
DNA strand elongation	R-HSA-69190	4.525932e-01	0.344	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	3.261875e-01	0.487	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	3.719041e-01	0.430	1	0
Generation of second messenger molecules	R-HSA-202433	5.000923e-01	0.301	1	1
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.818341e-01	0.235	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.936522e-01	0.405	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.486731e-01	0.348	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.818341e-01	0.235	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.818341e-01	0.235	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.503129e-01	0.602	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.731296e-01	0.428	0	0
Ovarian tumor domain proteases	R-HSA-5689896	4.328082e-01	0.364	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	5.537887e-01	0.257	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	5.724312e-01	0.242	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.480379e-01	0.261	0	0
Protein methylation	R-HSA-8876725	2.850045e-01	0.545	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	3.907793e-01	0.408	0	0
Potassium Channels	R-HSA-1296071	3.533054e-01	0.452	0	0
DNA Repair	R-HSA-73894	2.597301e-01	0.585	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	2.813559e-01	0.551	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	3.730623e-01	0.428	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	5.196222e-01	0.284	0	0
Regulation of insulin secretion	R-HSA-422356	4.797946e-01	0.319	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	2.953589e-01	0.530	0	0
Adaptive Immune System	R-HSA-1280218	3.305867e-01	0.481	1	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.380932e-01	0.623	0	0
Signaling by PTK6	R-HSA-8848021	3.115313e-01	0.506	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	3.115313e-01	0.506	0	0
MTF1 activates gene expression	R-HSA-5660489	2.097789e-01	0.678	0	0
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.331534e-01	0.363	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	4.331534e-01	0.363	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.650670e-01	0.438	0	0
Protein hydroxylation	R-HSA-9629569	2.834815e-01	0.547	0	0
Negative regulation of FLT3	R-HSA-9706369	3.165008e-01	0.500	0	0
MET interacts with TNS proteins	R-HSA-8875513	5.081617e-01	0.294	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.311465e-01	0.636	0	0
TGFBR3 expression	R-HSA-9839394	2.798000e-01	0.553	0	0
Signaling by LTK	R-HSA-9842663	3.961286e-01	0.402	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.624059e-01	0.335	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	2.831834e-01	0.548	0	0
Electric Transmission Across Gap Junctions	R-HSA-112303	5.732482e-01	0.242	0	0
Transmission across Electrical Synapses	R-HSA-112307	5.732482e-01	0.242	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	5.504263e-01	0.259	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	5.504263e-01	0.259	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	5.095741e-01	0.293	0	0
Platelet calcium homeostasis	R-HSA-418360	5.537887e-01	0.257	0	0
Disorders of Developmental Biology	R-HSA-9675151	5.724312e-01	0.242	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	5.904682e-01	0.229	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	5.922437e-01	0.227	0	0
FLT3 signaling in disease	R-HSA-9682385	4.100429e-01	0.387	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	4.785095e-01	0.320	0	0
Signaling by ERBB4	R-HSA-1236394	3.823445e-01	0.418	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	5.219734e-01	0.282	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	5.559424e-01	0.255	0	0
Pyroptosis	R-HSA-5620971	3.532562e-01	0.452	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	5.283619e-01	0.277	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	2.535675e-01	0.596	1	1
Signaling by NOTCH4	R-HSA-9013694	2.803060e-01	0.552	0	0
Heme signaling	R-HSA-9707616	5.339077e-01	0.273	0	0
PECAM1 interactions	R-HSA-210990	3.196914e-01	0.495	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	4.624059e-01	0.335	0	0
TBC/RABGAPs	R-HSA-8854214	3.021068e-01	0.520	0	0
MDK and PTN in ALK signaling	R-HSA-9851151	5.732482e-01	0.242	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	5.724312e-01	0.242	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.770210e-01	0.321	0	0
Oncogene Induced Senescence	R-HSA-2559585	3.872253e-01	0.412	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.154530e-01	0.381	0	0
Signaling by NTRKs	R-HSA-166520	5.737574e-01	0.241	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.138461e-01	0.503	0	0
Nef and signal transduction	R-HSA-164944	3.650670e-01	0.438	1	1
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.850045e-01	0.545	0	0
CHL1 interactions	R-HSA-447041	4.147501e-01	0.382	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	4.624059e-01	0.335	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.246152e-01	0.649	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	5.077012e-01	0.294	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	5.077012e-01	0.294	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	5.077012e-01	0.294	0	0
Interleukin-1 processing	R-HSA-448706	5.077012e-01	0.294	0	0
RAB geranylgeranylation	R-HSA-8873719	3.730623e-01	0.428	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	5.904682e-01	0.229	0	0
Degradation of CDH1	R-HSA-9766229	5.595538e-01	0.252	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.537887e-01	0.257	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.407615e-01	0.468	0	0
Signaling by TGFBR3	R-HSA-9839373	3.603840e-01	0.443	0	0
Amine ligand-binding receptors	R-HSA-375280	4.576240e-01	0.339	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.730623e-01	0.428	0	0
PI Metabolism	R-HSA-1483255	3.435708e-01	0.464	0	0
Co-inhibition by PD-1	R-HSA-389948	3.222528e-01	0.492	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	5.077012e-01	0.294	0	0
Stimuli-sensing channels	R-HSA-2672351	3.472470e-01	0.459	0	0
RUNX2 regulates bone development	R-HSA-8941326	5.707401e-01	0.244	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	2.567726e-01	0.590	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	4.116667e-01	0.385	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.055159e-01	0.296	0	0
Signaling by ALK	R-HSA-201556	3.311474e-01	0.480	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.999505e-01	0.398	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	5.023118e-01	0.299	0	0
DSCAM interactions	R-HSA-376172	4.331534e-01	0.363	0	0
Tandem pore domain potassium channels	R-HSA-1296346	2.813559e-01	0.551	0	0
Alpha-defensins	R-HSA-1462054	4.624059e-01	0.335	0	0
Maturation of nucleoprotein	R-HSA-9683610	4.335540e-01	0.363	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.603840e-01	0.443	0	0
Physiological factors	R-HSA-5578768	4.700870e-01	0.328	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.859117e-01	0.414	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.504263e-01	0.259	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	5.011176e-01	0.300	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.396732e-01	0.268	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	5.248114e-01	0.280	0	0
Synthesis of PI	R-HSA-1483226	5.904682e-01	0.229	0	0
Glucose metabolism	R-HSA-70326	2.422970e-01	0.616	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	2.425264e-01	0.615	0	0
Histamine receptors	R-HSA-390650	5.081617e-01	0.294	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.382118e-01	0.471	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	5.077012e-01	0.294	0	0
Selenocysteine synthesis	R-HSA-2408557	5.228848e-01	0.282	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	4.581984e-01	0.339	1	0
Formation of the anterior neural plate	R-HSA-9823739	5.055159e-01	0.296	0	0
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.331534e-01	0.363	0	0
MECP2 regulates transcription factors	R-HSA-9022707	4.147501e-01	0.382	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	4.147501e-01	0.382	0	0
Sodium/Proton exchangers	R-HSA-425986	4.624059e-01	0.335	0	0
Interleukin-18 signaling	R-HSA-9012546	4.624059e-01	0.335	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.732482e-01	0.242	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	5.649606e-01	0.248	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.888724e-01	0.230	1	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.039708e-01	0.517	0	0
Regulation of beta-cell development	R-HSA-186712	4.792517e-01	0.319	0	0
HDL assembly	R-HSA-8963896	2.540125e-01	0.595	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	5.037433e-01	0.298	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	4.130939e-01	0.384	0	0
Diseases of DNA repair	R-HSA-9675135	4.991917e-01	0.302	0	0
FasL/ CD95L signaling	R-HSA-75157	5.081617e-01	0.294	0	0
Signal regulatory protein family interactions	R-HSA-391160	4.700870e-01	0.328	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	5.904682e-01	0.229	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	2.751177e-01	0.560	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	4.116667e-01	0.385	0	0
SARS-CoV-1 Infection	R-HSA-9678108	3.428600e-01	0.465	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	4.335540e-01	0.363	1	1
STING mediated induction of host immune responses	R-HSA-1834941	2.567726e-01	0.590	0	0
Signaling by Leptin	R-HSA-2586552	5.504263e-01	0.259	0	0
Gene Silencing by RNA	R-HSA-211000	2.538344e-01	0.595	0	0
Growth hormone receptor signaling	R-HSA-982772	5.888724e-01	0.230	0	0
Degradation of DVL	R-HSA-4641258	5.928683e-01	0.227	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	5.928683e-01	0.227	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	5.928683e-01	0.227	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	5.979920e-01	0.223	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	5.990545e-01	0.223	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	6.025090e-01	0.220	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	6.025090e-01	0.220	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	6.025090e-01	0.220	1	1
Downstream signal transduction	R-HSA-186763	6.025090e-01	0.220	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	6.036975e-01	0.219	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.036975e-01	0.219	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	6.036975e-01	0.219	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	6.053821e-01	0.218	0	0
Ribosome-associated quality control	R-HSA-9948299	6.134155e-01	0.212	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.143798e-01	0.212	0	0
MET promotes cell motility	R-HSA-8875878	6.143798e-01	0.212	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.143798e-01	0.212	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	6.152728e-01	0.211	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	6.152728e-01	0.211	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	6.152728e-01	0.211	0	0
Deadenylation of mRNA	R-HSA-429947	6.152728e-01	0.211	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	6.152728e-01	0.211	0	0
Plasma lipoprotein assembly	R-HSA-8963898	6.152728e-01	0.211	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	6.165699e-01	0.210	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	6.165699e-01	0.210	0	0
Kidney development	R-HSA-9830369	6.199019e-01	0.208	0	0
PTEN Regulation	R-HSA-6807070	6.248732e-01	0.204	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	6.256976e-01	0.204	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.256976e-01	0.204	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	6.277889e-01	0.202	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	6.277889e-01	0.202	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	6.277889e-01	0.202	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	6.277889e-01	0.202	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	6.277889e-01	0.202	0	0
Integration of provirus	R-HSA-162592	6.277889e-01	0.202	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	6.277889e-01	0.202	0	0
Activation of AMPA receptors	R-HSA-399710	6.297249e-01	0.201	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	6.297249e-01	0.201	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	6.297249e-01	0.201	0	0
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	6.297249e-01	0.201	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	6.297249e-01	0.201	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	6.297249e-01	0.201	0	0
Defective F9 activation	R-HSA-9673221	6.297249e-01	0.201	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	6.297249e-01	0.201	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	6.297249e-01	0.201	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	6.297249e-01	0.201	0	0
Suppression of autophagy	R-HSA-9636569	6.297249e-01	0.201	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	6.297249e-01	0.201	0	0
PTK6 Down-Regulation	R-HSA-8849472	6.297249e-01	0.201	0	0
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	6.297249e-01	0.201	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	6.297249e-01	0.201	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	6.334108e-01	0.198	0	0
GAB1 signalosome	R-HSA-180292	6.334108e-01	0.198	0	0
Nephron development	R-HSA-9831926	6.334108e-01	0.198	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	6.346845e-01	0.197	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.346845e-01	0.197	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	6.346845e-01	0.197	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.352389e-01	0.197	0	0
Ion channel transport	R-HSA-983712	6.357256e-01	0.197	0	0
Transcription of the HIV genome	R-HSA-167172	6.361080e-01	0.196	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.399816e-01	0.194	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.405902e-01	0.193	0	0
Acyl chain remodelling of PS	R-HSA-1482801	6.405902e-01	0.193	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	6.413608e-01	0.193	0	0
Aquaporin-mediated transport	R-HSA-445717	6.436173e-01	0.191	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	6.440702e-01	0.191	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	6.480519e-01	0.188	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.480519e-01	0.188	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.545026e-01	0.184	0	0
Attenuation phase	R-HSA-3371568	6.554165e-01	0.183	0	0
Glycogen metabolism	R-HSA-8982491	6.554165e-01	0.183	0	0
Interleukin-2 family signaling	R-HSA-451927	6.554165e-01	0.183	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	6.554165e-01	0.183	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.570233e-01	0.182	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	6.570233e-01	0.182	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	6.615363e-01	0.179	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.615363e-01	0.179	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.615363e-01	0.179	0	0
Specification of the neural plate border	R-HSA-9834899	6.615363e-01	0.179	0	0
The NLRP3 inflammasome	R-HSA-844456	6.615363e-01	0.179	0	0
Maturation of nucleoprotein	R-HSA-9694631	6.615363e-01	0.179	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	6.624074e-01	0.179	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	6.624074e-01	0.179	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	6.624074e-01	0.179	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.624074e-01	0.179	0	0
IRAK1 recruits IKK complex	R-HSA-937039	6.624074e-01	0.179	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	6.624074e-01	0.179	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	6.624074e-01	0.179	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	6.624074e-01	0.179	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.624074e-01	0.179	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.624074e-01	0.179	0	0
Pervasive developmental disorders	R-HSA-9005895	6.624074e-01	0.179	0	0
Disorders of Nervous System Development	R-HSA-9697154	6.624074e-01	0.179	0	0
Leading Strand Synthesis	R-HSA-69109	6.624074e-01	0.179	0	0
Polymerase switching	R-HSA-69091	6.624074e-01	0.179	0	0
Interleukin-15 signaling	R-HSA-8983432	6.624074e-01	0.179	0	0
OAS antiviral response	R-HSA-8983711	6.624074e-01	0.179	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	6.625579e-01	0.179	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	6.625579e-01	0.179	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	6.647907e-01	0.177	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	6.647907e-01	0.177	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	6.647907e-01	0.177	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	6.647907e-01	0.177	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	6.678837e-01	0.175	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	6.695437e-01	0.174	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	6.695437e-01	0.174	0	0
Maturation of spike protein	R-HSA-9694548	6.748895e-01	0.171	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.760514e-01	0.170	0	0
PDE3B signalling	R-HSA-165160	6.787303e-01	0.168	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	6.787303e-01	0.168	0	0
PKB-mediated events	R-HSA-109703	6.787303e-01	0.168	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.787303e-01	0.168	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.787303e-01	0.168	0	0
Signaling by MAPK mutants	R-HSA-9652817	6.787303e-01	0.168	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.787303e-01	0.168	0	0
Signaling by RNF43 mutants	R-HSA-5340588	6.787303e-01	0.168	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.787303e-01	0.168	0	0
Pentose phosphate pathway disease	R-HSA-6791465	6.787303e-01	0.168	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	6.787303e-01	0.168	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	6.787303e-01	0.168	0	0
Formation of the Editosome	R-HSA-75094	6.787303e-01	0.168	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.787303e-01	0.168	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	6.787303e-01	0.168	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	6.787303e-01	0.168	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.787303e-01	0.168	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.787303e-01	0.168	0	0
TRAIL signaling	R-HSA-75158	6.787303e-01	0.168	0	0
GPER1 signaling	R-HSA-9634597	6.804483e-01	0.167	0	0
NGF-stimulated transcription	R-HSA-9031628	6.804483e-01	0.167	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	6.824075e-01	0.166	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.878534e-01	0.163	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	6.878534e-01	0.163	0	0
Cristae formation	R-HSA-8949613	6.878534e-01	0.163	0	0
Signaling by NODAL	R-HSA-1181150	6.880624e-01	0.162	0	0
Signal transduction by L1	R-HSA-445144	6.880624e-01	0.162	0	0
Creatine metabolism	R-HSA-71288	6.880624e-01	0.162	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.885199e-01	0.162	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	6.901532e-01	0.161	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	6.901532e-01	0.161	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	6.901532e-01	0.161	0	0
Nuclear import of Rev protein	R-HSA-180746	6.901532e-01	0.161	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.915826e-01	0.160	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	6.936408e-01	0.159	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	6.943850e-01	0.158	0	0
FGFR1c ligand binding and activation	R-HSA-190373	6.943850e-01	0.158	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	6.943850e-01	0.158	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	6.943850e-01	0.158	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	6.943850e-01	0.158	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	6.943850e-01	0.158	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	6.970244e-01	0.157	0	0
Gap junction trafficking and regulation	R-HSA-157858	6.977267e-01	0.156	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.989639e-01	0.156	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.989639e-01	0.156	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.023449e-01	0.153	0	0
Cellular response to hypoxia	R-HSA-1234174	7.066419e-01	0.151	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	7.066419e-01	0.151	1	1
Activation of AMPK downstream of NMDARs	R-HSA-9619483	7.097693e-01	0.149	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	7.097693e-01	0.149	0	0
Regulation of Apoptosis	R-HSA-169911	7.098682e-01	0.149	1	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	7.098682e-01	0.149	0	0
Signalling to RAS	R-HSA-167044	7.129964e-01	0.147	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.129964e-01	0.147	0	0
Erythropoietin activates STAT5	R-HSA-9027283	7.212523e-01	0.142	0	0
STAT5 Activation	R-HSA-9645135	7.212523e-01	0.142	0	0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	7.212523e-01	0.142	0	0
G2/M DNA replication checkpoint	R-HSA-69478	7.212523e-01	0.142	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	7.212523e-01	0.142	0	0
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	7.212523e-01	0.142	0	0
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	7.212523e-01	0.142	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	7.212523e-01	0.142	0	0
Neurofascin interactions	R-HSA-447043	7.212523e-01	0.142	0	0
Lactose synthesis	R-HSA-5653890	7.212523e-01	0.142	0	0
CREB phosphorylation	R-HSA-199920	7.212523e-01	0.142	0	0
NADPH regeneration	R-HSA-389542	7.212523e-01	0.142	0	0
Lipid particle organization	R-HSA-8964572	7.212523e-01	0.142	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.222926e-01	0.141	0	0
Prolactin receptor signaling	R-HSA-1170546	7.238144e-01	0.140	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	7.238144e-01	0.140	0	0
Removal of the Flap Intermediate	R-HSA-69166	7.238144e-01	0.140	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.238144e-01	0.140	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	7.238144e-01	0.140	0	0
CRMPs in Sema3A signaling	R-HSA-399956	7.238144e-01	0.140	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	7.238144e-01	0.140	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	7.238144e-01	0.140	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	7.238144e-01	0.140	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	7.238144e-01	0.140	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	7.238144e-01	0.140	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	7.250686e-01	0.140	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.269507e-01	0.138	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	7.286836e-01	0.137	0	0
Signaling by FGFR4	R-HSA-5654743	7.289360e-01	0.137	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	7.289360e-01	0.137	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	7.291595e-01	0.137	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	7.305395e-01	0.136	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	7.305395e-01	0.136	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	7.314848e-01	0.136	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	7.314848e-01	0.136	0	0
Triglyceride metabolism	R-HSA-8979227	7.326275e-01	0.135	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.334657e-01	0.135	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	7.343607e-01	0.134	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.363617e-01	0.133	0	0
Attachment and Entry	R-HSA-9694614	7.363617e-01	0.133	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.363617e-01	0.133	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.363617e-01	0.133	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	7.367339e-01	0.133	0	0
ISG15 antiviral mechanism	R-HSA-1169408	7.383019e-01	0.132	0	0
DAP12 interactions	R-HSA-2172127	7.454710e-01	0.128	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	7.466006e-01	0.127	0	0
SARS-CoV-2 Infection	R-HSA-9694516	7.478024e-01	0.126	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	7.489196e-01	0.126	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	7.508098e-01	0.124	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	7.508098e-01	0.124	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	7.508098e-01	0.124	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	7.508098e-01	0.124	0	0
Processive synthesis on the lagging strand	R-HSA-69183	7.508098e-01	0.124	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	7.508098e-01	0.124	0	0
p38MAPK events	R-HSA-171007	7.508098e-01	0.124	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	7.508098e-01	0.124	0	0
Biotin transport and metabolism	R-HSA-196780	7.508098e-01	0.124	0	0
Cellular response to starvation	R-HSA-9711097	7.524610e-01	0.124	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	7.581484e-01	0.120	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.581484e-01	0.120	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	7.581484e-01	0.120	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.581484e-01	0.120	0	0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	7.581484e-01	0.120	0	0
Disinhibition of SNARE formation	R-HSA-114516	7.581484e-01	0.120	0	0
PTK6 Expression	R-HSA-8849473	7.581484e-01	0.120	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	7.581484e-01	0.120	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	7.581484e-01	0.120	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	7.581484e-01	0.120	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	7.581484e-01	0.120	0	0
Glycoprotein hormones	R-HSA-209822	7.581484e-01	0.120	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	7.581484e-01	0.120	0	0
Signaling by KIT in disease	R-HSA-9669938	7.581943e-01	0.120	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.581943e-01	0.120	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.581943e-01	0.120	0	0
FGFR2 alternative splicing	R-HSA-6803529	7.581943e-01	0.120	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.581943e-01	0.120	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.581943e-01	0.120	0	0
Ethanol oxidation	R-HSA-71384	7.581943e-01	0.120	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	7.609371e-01	0.119	0	0
MAP kinase activation	R-HSA-450294	7.609371e-01	0.119	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.612655e-01	0.118	0	0
Signaling by FGFR3	R-HSA-5654741	7.612655e-01	0.118	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.612655e-01	0.118	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	7.636258e-01	0.117	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	7.636292e-01	0.117	0	0
Adipogenesis	R-HSA-9843745	7.650600e-01	0.116	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	7.686911e-01	0.114	0	0
Budding and maturation of HIV virion	R-HSA-162588	7.686911e-01	0.114	0	0
Signaling by TGFB family members	R-HSA-9006936	7.697207e-01	0.114	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	7.742640e-01	0.111	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	7.746948e-01	0.111	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.752329e-01	0.111	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	7.754999e-01	0.110	0	0
Attachment and Entry	R-HSA-9678110	7.754999e-01	0.110	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	7.754999e-01	0.110	0	0
Fructose catabolism	R-HSA-70350	7.754999e-01	0.110	0	0
Regulation of BACH1 activity	R-HSA-9708530	7.754999e-01	0.110	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	7.754999e-01	0.110	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	7.754999e-01	0.110	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.763251e-01	0.110	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	7.770223e-01	0.110	0	0
HIV Infection	R-HSA-162906	7.774312e-01	0.109	1	0
Termination of O-glycan biosynthesis	R-HSA-977068	7.785408e-01	0.109	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.785408e-01	0.109	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	7.787192e-01	0.109	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	7.797709e-01	0.108	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	7.797709e-01	0.108	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	7.797709e-01	0.108	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	7.844112e-01	0.105	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.861145e-01	0.105	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.870427e-01	0.104	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	7.882007e-01	0.103	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	7.886931e-01	0.103	0	0
RSK activation	R-HSA-444257	7.901627e-01	0.102	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.901627e-01	0.102	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.901627e-01	0.102	0	0
Interleukin-9 signaling	R-HSA-8985947	7.901627e-01	0.102	0	0
Co-stimulation by ICOS	R-HSA-9927354	7.901627e-01	0.102	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.901627e-01	0.102	0	0
TGFBR3 PTM regulation	R-HSA-9839383	7.901627e-01	0.102	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	7.901627e-01	0.102	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	7.901627e-01	0.102	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.950517e-01	0.100	0	0
Diseases of Immune System	R-HSA-5260271	7.950517e-01	0.100	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	7.950517e-01	0.100	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	7.950517e-01	0.100	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	7.965539e-01	0.099	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	7.974553e-01	0.098	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	7.974553e-01	0.098	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.974553e-01	0.098	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	7.980218e-01	0.098	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.980218e-01	0.098	0	0
Phase 2 - plateau phase	R-HSA-5576893	7.980218e-01	0.098	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	7.980218e-01	0.098	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	7.980218e-01	0.098	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	7.980218e-01	0.098	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	7.980218e-01	0.098	0	0
Passive transport by Aquaporins	R-HSA-432047	7.980218e-01	0.098	0	0
tRNA modification in the mitochondrion	R-HSA-6787450	7.980218e-01	0.098	0	0
Synthesis of PG	R-HSA-1483148	7.980218e-01	0.098	0	0
Response to metal ions	R-HSA-5660526	7.980218e-01	0.098	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.984420e-01	0.098	0	0
IGF1R signaling cascade	R-HSA-2428924	7.992782e-01	0.097	0	0
Ion transport by P-type ATPases	R-HSA-936837	7.992782e-01	0.097	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.010895e-01	0.096	0	0
Signaling by FGFR1	R-HSA-5654736	8.010895e-01	0.096	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.024737e-01	0.096	0	0
HCMV Late Events	R-HSA-9610379	8.070727e-01	0.093	0	0
HIV Life Cycle	R-HSA-162587	8.070727e-01	0.093	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.093578e-01	0.092	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	8.094876e-01	0.092	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.094876e-01	0.092	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	8.094876e-01	0.092	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.094876e-01	0.092	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	8.094876e-01	0.092	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	8.106332e-01	0.091	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	8.109776e-01	0.091	0	0
IRS-mediated signalling	R-HSA-112399	8.133709e-01	0.090	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.139083e-01	0.089	1	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.145920e-01	0.089	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.149981e-01	0.089	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.149981e-01	0.089	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	8.149981e-01	0.089	0	0
G protein gated Potassium channels	R-HSA-1296059	8.149981e-01	0.089	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	8.160285e-01	0.088	0	0
DNA Damage Bypass	R-HSA-73893	8.171993e-01	0.088	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	8.178026e-01	0.087	0	0
Vpu mediated degradation of CD4	R-HSA-180534	8.178026e-01	0.087	0	0
Miscellaneous transport and binding events	R-HSA-5223345	8.178026e-01	0.087	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	8.179407e-01	0.087	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	8.179407e-01	0.087	0	0
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	8.179407e-01	0.087	0	0
Regulation of signaling by NODAL	R-HSA-1433617	8.179407e-01	0.087	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	8.179407e-01	0.087	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	8.179407e-01	0.087	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	8.179407e-01	0.087	0	0
Lysosomal oligosaccharide catabolism	R-HSA-8853383	8.179407e-01	0.087	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	8.179407e-01	0.087	0	0
HCMV Early Events	R-HSA-9609690	8.182566e-01	0.087	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	8.185169e-01	0.087	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	8.185169e-01	0.087	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	8.185169e-01	0.087	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.185169e-01	0.087	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.185169e-01	0.087	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	8.185169e-01	0.087	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.185169e-01	0.087	0	0
Intra-Golgi traffic	R-HSA-6811438	8.231009e-01	0.085	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.231009e-01	0.085	0	0
Dual incision in TC-NER	R-HSA-6782135	8.250566e-01	0.084	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.250566e-01	0.084	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	8.280437e-01	0.082	0	0
PI3K Cascade	R-HSA-109704	8.294369e-01	0.081	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.305420e-01	0.081	0	0
Myogenesis	R-HSA-525793	8.312336e-01	0.080	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.312336e-01	0.080	0	0
Metalloprotease DUBs	R-HSA-5689901	8.312336e-01	0.080	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.312336e-01	0.080	0	0
Abacavir ADME	R-HSA-2161522	8.312336e-01	0.080	0	0
Dual Incision in GG-NER	R-HSA-5696400	8.321383e-01	0.080	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	8.342457e-01	0.079	0	0
Toll-like Receptor Cascades	R-HSA-168898	8.356995e-01	0.078	0	0
Extension of Telomeres	R-HSA-180786	8.361599e-01	0.078	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	8.361599e-01	0.078	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.371270e-01	0.077	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	8.371270e-01	0.077	0	0
FGFR1 ligand binding and activation	R-HSA-190242	8.371270e-01	0.077	0	0
Tie2 Signaling	R-HSA-210993	8.371270e-01	0.077	0	0
Platelet sensitization by LDL	R-HSA-432142	8.371270e-01	0.077	0	0
Mismatch Repair	R-HSA-5358508	8.371270e-01	0.077	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	8.371270e-01	0.077	0	0
Circadian clock	R-HSA-9909396	8.383311e-01	0.077	0	0
Interleukin-12 signaling	R-HSA-9020591	8.403170e-01	0.076	1	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.410100e-01	0.075	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	8.410100e-01	0.075	0	0
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.420430e-01	0.075	0	0
Metabolism of serotonin	R-HSA-380612	8.420430e-01	0.075	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	8.420430e-01	0.075	0	0
Formation of intermediate mesoderm	R-HSA-9761174	8.420430e-01	0.075	0	0
Arachidonate production from DAG	R-HSA-426048	8.420430e-01	0.075	0	0
Pexophagy	R-HSA-9664873	8.420430e-01	0.075	0	0
Maturation of spike protein	R-HSA-9683686	8.420430e-01	0.075	0	0
Sperm Motility And Taxes	R-HSA-1300642	8.420430e-01	0.075	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	8.420430e-01	0.075	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	8.420430e-01	0.075	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.420430e-01	0.075	0	0
Peptide hormone biosynthesis	R-HSA-209952	8.420430e-01	0.075	0	0
Josephin domain DUBs	R-HSA-5689877	8.420430e-01	0.075	0	0
Nucleotide Excision Repair	R-HSA-5696398	8.446949e-01	0.073	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	8.455206e-01	0.073	0	0
IRE1alpha activates chaperones	R-HSA-381070	8.461006e-01	0.073	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.462288e-01	0.073	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	8.462288e-01	0.073	0	0
Signaling by BMP	R-HSA-201451	8.462288e-01	0.073	0	0
GABA receptor activation	R-HSA-977443	8.466953e-01	0.072	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	8.479618e-01	0.072	0	0
Translation of Structural Proteins	R-HSA-9694635	8.496448e-01	0.071	0	0
Immune System	R-HSA-168256	8.509694e-01	0.070	1	0
Uptake and actions of bacterial toxins	R-HSA-5339562	8.519388e-01	0.070	0	0
Regulation of signaling by CBL	R-HSA-912631	8.539918e-01	0.069	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	8.539918e-01	0.069	0	0
Other interleukin signaling	R-HSA-449836	8.539918e-01	0.069	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.539918e-01	0.069	0	0
Influenza Infection	R-HSA-168255	8.572828e-01	0.067	0	0
GPVI-mediated activation cascade	R-HSA-114604	8.579910e-01	0.067	0	0
Glycosphingolipid transport	R-HSA-9845576	8.579910e-01	0.067	0	0
Proteasome assembly	R-HSA-9907900	8.592648e-01	0.066	0	0
Gap junction trafficking	R-HSA-190828	8.592648e-01	0.066	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.600521e-01	0.065	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.600521e-01	0.065	0	0
Inflammasomes	R-HSA-622312	8.600521e-01	0.065	0	0
Interleukin-17 signaling	R-HSA-448424	8.617750e-01	0.065	0	0
Amino acids regulate mTORC1	R-HSA-9639288	8.622445e-01	0.064	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.629556e-01	0.064	0	0
FGFR2b ligand binding and activation	R-HSA-190377	8.629556e-01	0.064	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	8.629556e-01	0.064	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.629556e-01	0.064	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	8.629556e-01	0.064	0	0
Bicarbonate transporters	R-HSA-425381	8.629556e-01	0.064	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.629556e-01	0.064	0	0
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	8.629556e-01	0.064	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.629556e-01	0.064	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.629556e-01	0.064	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	8.629556e-01	0.064	0	0
Prostanoid ligand receptors	R-HSA-391908	8.629556e-01	0.064	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.643799e-01	0.063	0	0
Signaling by PDGF	R-HSA-186797	8.661268e-01	0.062	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	8.684698e-01	0.061	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	8.692473e-01	0.061	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.692473e-01	0.061	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	8.692473e-01	0.061	0	0
Nephrin family interactions	R-HSA-373753	8.692473e-01	0.061	0	0
Degradation of AXIN	R-HSA-4641257	8.695922e-01	0.061	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	8.698553e-01	0.061	0	0
Somitogenesis	R-HSA-9824272	8.698553e-01	0.061	0	0
Interferon gamma signaling	R-HSA-877300	8.725440e-01	0.059	0	0
mRNA Capping	R-HSA-72086	8.727722e-01	0.059	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.727722e-01	0.059	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	8.727722e-01	0.059	0	0
Signaling by FGFR2	R-HSA-5654738	8.750519e-01	0.058	0	0
Host Interactions of HIV factors	R-HSA-162909	8.789558e-01	0.056	1	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	8.797637e-01	0.056	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.811006e-01	0.055	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.811006e-01	0.055	0	0
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.811006e-01	0.055	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	8.811006e-01	0.055	0	0
ERKs are inactivated	R-HSA-202670	8.811006e-01	0.055	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.811006e-01	0.055	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.811006e-01	0.055	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	8.811006e-01	0.055	0	0
Sodium/Calcium exchangers	R-HSA-425561	8.811006e-01	0.055	0	0
Uptake of dietary cobalamins into enterocytes	R-HSA-9758881	8.811006e-01	0.055	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	8.830239e-01	0.054	0	0
Lagging Strand Synthesis	R-HSA-69186	8.830239e-01	0.054	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.830239e-01	0.054	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.830239e-01	0.054	0	0
ERK/MAPK targets	R-HSA-198753	8.830239e-01	0.054	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	8.830239e-01	0.054	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	8.830239e-01	0.054	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	8.830239e-01	0.054	0	0
Insulin receptor signalling cascade	R-HSA-74751	8.834879e-01	0.054	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	8.844574e-01	0.053	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.844574e-01	0.053	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.844574e-01	0.053	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.844574e-01	0.053	0	0
ER-Phagosome pathway	R-HSA-1236974	8.868121e-01	0.052	0	0
Downstream TCR signaling	R-HSA-202424	8.935771e-01	0.049	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.951748e-01	0.048	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	8.954456e-01	0.048	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	8.954456e-01	0.048	0	0
GRB2 events in EGFR signaling	R-HSA-179812	8.968440e-01	0.047	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	8.968440e-01	0.047	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	8.968440e-01	0.047	0	0
Scavenging by Class F Receptors	R-HSA-3000484	8.968440e-01	0.047	0	0
MET activates RAS signaling	R-HSA-8851805	8.968440e-01	0.047	0	0
VLDLR internalisation and degradation	R-HSA-8866427	8.968440e-01	0.047	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	8.968440e-01	0.047	0	0
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	8.968440e-01	0.047	0	0
Estrogen biosynthesis	R-HSA-193144	8.968440e-01	0.047	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.968440e-01	0.047	0	0
Intraflagellar transport	R-HSA-5620924	8.976581e-01	0.047	0	0
G alpha (s) signalling events	R-HSA-418555	8.986045e-01	0.046	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.996150e-01	0.046	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	8.996150e-01	0.046	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	8.996150e-01	0.046	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	9.033651e-01	0.044	0	0
Gastrulation	R-HSA-9758941	9.042773e-01	0.044	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	9.066297e-01	0.043	0	0
Fructose metabolism	R-HSA-5652084	9.066297e-01	0.043	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.066297e-01	0.043	0	0
Cellular hexose transport	R-HSA-189200	9.066297e-01	0.043	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.066297e-01	0.043	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.066297e-01	0.043	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.066297e-01	0.043	0	0
UCH proteinases	R-HSA-5689603	9.075005e-01	0.042	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.081729e-01	0.042	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	9.105037e-01	0.041	0	0
Adenylate cyclase activating pathway	R-HSA-170660	9.105037e-01	0.041	0	0
FGFR2c ligand binding and activation	R-HSA-190375	9.105037e-01	0.041	0	0
FGFR4 ligand binding and activation	R-HSA-190322	9.105037e-01	0.041	0	0
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	9.105037e-01	0.041	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	9.105037e-01	0.041	0	0
Acetylcholine binding and downstream events	R-HSA-181431	9.105037e-01	0.041	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	9.105037e-01	0.041	0	0
Chylomicron remodeling	R-HSA-8963901	9.105037e-01	0.041	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	9.105037e-01	0.041	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	9.105037e-01	0.041	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	9.105037e-01	0.041	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	9.105037e-01	0.041	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	9.105037e-01	0.041	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	9.105037e-01	0.041	0	0
Interleukin-6 signaling	R-HSA-1059683	9.105037e-01	0.041	0	0
Neddylation	R-HSA-8951664	9.117122e-01	0.040	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.118801e-01	0.040	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	9.131957e-01	0.039	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.139653e-01	0.039	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.160763e-01	0.038	0	0
HIV Transcription Initiation	R-HSA-167161	9.160763e-01	0.038	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.160763e-01	0.038	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.160763e-01	0.038	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.160763e-01	0.038	0	0
Translation of Structural Proteins	R-HSA-9683701	9.160763e-01	0.038	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.166861e-01	0.038	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.166861e-01	0.038	0	0
Biosynthesis of maresins	R-HSA-9018682	9.166861e-01	0.038	0	0
Carnitine shuttle	R-HSA-200425	9.166861e-01	0.038	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.166861e-01	0.038	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.171086e-01	0.038	0	0
Integrin cell surface interactions	R-HSA-216083	9.195657e-01	0.036	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	9.208784e-01	0.036	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.221621e-01	0.035	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.223552e-01	0.035	0	0
Retrograde neurotrophin signalling	R-HSA-177504	9.223552e-01	0.035	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	9.223552e-01	0.035	0	0
FGFR3c ligand binding and activation	R-HSA-190372	9.223552e-01	0.035	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	9.223552e-01	0.035	0	0
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	9.223552e-01	0.035	0	0
Glycerophospholipid catabolism	R-HSA-6814848	9.223552e-01	0.035	0	0
Malate-aspartate shuttle	R-HSA-9856872	9.223552e-01	0.035	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.223552e-01	0.035	0	0
Ciprofloxacin ADME	R-HSA-9793528	9.223552e-01	0.035	0	0
P2Y receptors	R-HSA-417957	9.223552e-01	0.035	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.225608e-01	0.035	0	0
Activation of GABAB receptors	R-HSA-991365	9.233659e-01	0.035	0	0
GABA B receptor activation	R-HSA-977444	9.233659e-01	0.035	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	9.250143e-01	0.034	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.250143e-01	0.034	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.257172e-01	0.034	0	0
TNFs bind their physiological receptors	R-HSA-5669034	9.257172e-01	0.034	0	0
Chaperonin-mediated protein folding	R-HSA-390466	9.260779e-01	0.033	0	0
Interleukin-12 family signaling	R-HSA-447115	9.260779e-01	0.033	1	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.266203e-01	0.033	0	0
Mitochondrial biogenesis	R-HSA-1592230	9.287608e-01	0.032	0	0
PPARA activates gene expression	R-HSA-1989781	9.295600e-01	0.032	0	0
Hyaluronan metabolism	R-HSA-2142845	9.296380e-01	0.032	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.296380e-01	0.032	0	0
RA biosynthesis pathway	R-HSA-5365859	9.296380e-01	0.032	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	9.296380e-01	0.032	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	9.300811e-01	0.031	0	0
Signaling by MET	R-HSA-6806834	9.302508e-01	0.031	0	0
tRNA processing in the nucleus	R-HSA-6784531	9.307533e-01	0.031	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.326379e-01	0.030	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.326379e-01	0.030	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	9.326379e-01	0.030	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	9.326379e-01	0.030	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	9.326379e-01	0.030	0	0
SHC1 events in EGFR signaling	R-HSA-180336	9.326379e-01	0.030	0	0
Signaling by Activin	R-HSA-1502540	9.326379e-01	0.030	0	0
FGFR3 ligand binding and activation	R-HSA-190239	9.326379e-01	0.030	0	0
DNA Damage Reversal	R-HSA-73942	9.326379e-01	0.030	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.338182e-01	0.030	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.338182e-01	0.030	0	0
Laminin interactions	R-HSA-3000157	9.338182e-01	0.030	0	0
Hyaluronan degradation	R-HSA-2160916	9.338182e-01	0.030	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.364481e-01	0.029	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.364481e-01	0.029	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.364481e-01	0.029	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.366318e-01	0.028	0	0
Neurotransmitter release cycle	R-HSA-112310	9.399453e-01	0.027	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.410769e-01	0.026	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	9.410769e-01	0.026	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	9.410769e-01	0.026	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.410769e-01	0.026	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	9.415594e-01	0.026	0	0
Killing mechanisms	R-HSA-9664420	9.415594e-01	0.026	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	9.415594e-01	0.026	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.415594e-01	0.026	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	9.415594e-01	0.026	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	9.415594e-01	0.026	0	0
Atorvastatin ADME	R-HSA-9754706	9.415594e-01	0.026	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.419383e-01	0.026	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.419383e-01	0.026	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.426445e-01	0.026	0	0
G alpha (z) signalling events	R-HSA-418597	9.433026e-01	0.025	0	0
Signaling by NOTCH3	R-HSA-9012852	9.433026e-01	0.025	0	0
Signaling by FGFR	R-HSA-190236	9.445180e-01	0.025	0	0
Platelet homeostasis	R-HSA-418346	9.453018e-01	0.024	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.471515e-01	0.024	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.471515e-01	0.024	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.471515e-01	0.024	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.475744e-01	0.023	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.475744e-01	0.023	0	0
Triglyceride biosynthesis	R-HSA-75109	9.475744e-01	0.023	0	0
Synthesis of PE	R-HSA-1483213	9.475744e-01	0.023	0	0
NCAM1 interactions	R-HSA-419037	9.482761e-01	0.023	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.486098e-01	0.023	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.492997e-01	0.023	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.492997e-01	0.023	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.492997e-01	0.023	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.492997e-01	0.023	0	0
Coenzyme A biosynthesis	R-HSA-196783	9.492997e-01	0.023	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.492997e-01	0.023	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.492997e-01	0.023	0	0
HCMV Infection	R-HSA-9609646	9.501801e-01	0.022	0	0
Protein folding	R-HSA-391251	9.514813e-01	0.022	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	9.529004e-01	0.021	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.560153e-01	0.020	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.560153e-01	0.020	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	9.560153e-01	0.020	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.560153e-01	0.020	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.560153e-01	0.020	0	0
Glycogen storage diseases	R-HSA-3229121	9.560153e-01	0.020	0	0
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	9.560153e-01	0.020	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	9.560153e-01	0.020	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	9.560153e-01	0.020	0	0
Catecholamine biosynthesis	R-HSA-209905	9.560153e-01	0.020	0	0
GDP-fucose biosynthesis	R-HSA-6787639	9.560153e-01	0.020	0	0
Choline catabolism	R-HSA-6798163	9.560153e-01	0.020	0	0
Metal ion SLC transporters	R-HSA-425410	9.563125e-01	0.019	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.568303e-01	0.019	0	0
Pentose phosphate pathway	R-HSA-71336	9.580261e-01	0.019	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	9.585764e-01	0.018	0	0
ABC transporter disorders	R-HSA-5619084	9.594832e-01	0.018	0	0
SARS-CoV Infections	R-HSA-9679506	9.602611e-01	0.018	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	9.618416e-01	0.017	0	0
Activated point mutants of FGFR2	R-HSA-2033519	9.618416e-01	0.017	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	9.618416e-01	0.017	0	0
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	9.618416e-01	0.017	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.618416e-01	0.017	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	9.618416e-01	0.017	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.618416e-01	0.017	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.618416e-01	0.017	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.622278e-01	0.017	0	0
Neurotransmitter clearance	R-HSA-112311	9.632109e-01	0.016	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.632109e-01	0.016	0	0
Inositol phosphate metabolism	R-HSA-1483249	9.635215e-01	0.016	0	0
rRNA processing	R-HSA-72312	9.635322e-01	0.016	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.636439e-01	0.016	0	0
Pyrimidine biosynthesis	R-HSA-500753	9.668965e-01	0.015	0	0
Translesion Synthesis by POLH	R-HSA-110320	9.668965e-01	0.015	0	0
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	9.668965e-01	0.015	0	0
Diseases of hemostasis	R-HSA-9671793	9.668965e-01	0.015	0	0
ECM proteoglycans	R-HSA-3000178	9.672309e-01	0.014	0	0
The phototransduction cascade	R-HSA-2514856	9.673354e-01	0.014	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.673447e-01	0.014	0	0
Cargo concentration in the ER	R-HSA-5694530	9.673447e-01	0.014	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.673447e-01	0.014	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.673447e-01	0.014	0	0
Aspartate and asparagine metabolism	R-HSA-8963693	9.673447e-01	0.014	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.680185e-01	0.014	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.682339e-01	0.014	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.703918e-01	0.013	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.712820e-01	0.013	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	9.712820e-01	0.013	0	0
Glycogen synthesis	R-HSA-3322077	9.712820e-01	0.013	0	0
Negative regulation of MET activity	R-HSA-6807004	9.712820e-01	0.013	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.712820e-01	0.013	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	9.712820e-01	0.013	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.730702e-01	0.012	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.730702e-01	0.012	0	0
Hemostasis	R-HSA-109582	9.734901e-01	0.012	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	9.743110e-01	0.011	0	0
FGFR2 ligand binding and activation	R-HSA-190241	9.750868e-01	0.011	0	0
G-protein activation	R-HSA-202040	9.750868e-01	0.011	0	0
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.750868e-01	0.011	0	0
Acyl chain remodelling of PG	R-HSA-1482925	9.750868e-01	0.011	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.750868e-01	0.011	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.750868e-01	0.011	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.750868e-01	0.011	0	0
Abacavir metabolism	R-HSA-2161541	9.750868e-01	0.011	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.750868e-01	0.011	0	0
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.750868e-01	0.011	0	0
Basigin interactions	R-HSA-210991	9.750868e-01	0.011	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.751941e-01	0.011	0	0
Signaling by Insulin receptor	R-HSA-74752	9.760298e-01	0.011	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.772319e-01	0.010	0	0
Heme degradation	R-HSA-189483	9.772319e-01	0.010	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.775274e-01	0.010	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.775913e-01	0.010	0	0
GPCR downstream signalling	R-HSA-388396	9.776079e-01	0.010	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.778858e-01	0.010	0	0
Ribavirin ADME	R-HSA-9755088	9.783876e-01	0.009	0	0
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.783876e-01	0.009	0	0
Assembly Of The HIV Virion	R-HSA-175474	9.783876e-01	0.009	0	0
Glutathione synthesis and recycling	R-HSA-174403	9.783876e-01	0.009	0	0
eNOS activation	R-HSA-203615	9.798300e-01	0.009	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.798300e-01	0.009	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.798300e-01	0.009	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.798300e-01	0.009	0	0
Gap junction assembly	R-HSA-190861	9.798300e-01	0.009	0	0
Signal amplification	R-HSA-392518	9.798300e-01	0.009	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.801348e-01	0.009	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.801348e-01	0.009	0	0
Fanconi Anemia Pathway	R-HSA-6783310	9.802011e-01	0.009	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.804009e-01	0.009	0	0
Platelet degranulation	R-HSA-114608	9.805411e-01	0.009	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.810046e-01	0.008	0	0
Biosynthesis of D-series resolvins	R-HSA-9018676	9.812513e-01	0.008	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.812513e-01	0.008	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.812513e-01	0.008	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	9.812513e-01	0.008	0	0
LDL clearance	R-HSA-8964038	9.812513e-01	0.008	0	0
Dectin-2 family	R-HSA-5621480	9.820472e-01	0.008	0	0
Synthesis of PA	R-HSA-1483166	9.820472e-01	0.008	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.821395e-01	0.008	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.821395e-01	0.008	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.822574e-01	0.008	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.837357e-01	0.007	0	0
Formation of the ureteric bud	R-HSA-9830674	9.837357e-01	0.007	0	0
ABC transporters in lipid homeostasis	R-HSA-1369062	9.837357e-01	0.007	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.838459e-01	0.007	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.841085e-01	0.007	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.853614e-01	0.006	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.853614e-01	0.006	0	0
Gluconeogenesis	R-HSA-70263	9.857737e-01	0.006	0	0
CYP2E1 reactions	R-HSA-211999	9.858910e-01	0.006	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.858910e-01	0.006	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.858910e-01	0.006	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.858910e-01	0.006	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.858910e-01	0.006	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.858910e-01	0.006	0	0
Interleukin-6 family signaling	R-HSA-6783589	9.858910e-01	0.006	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.860131e-01	0.006	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	9.860131e-01	0.006	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.860131e-01	0.006	0	0
Collagen chain trimerization	R-HSA-8948216	9.860131e-01	0.006	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	9.862168e-01	0.006	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.867919e-01	0.006	0	0
Metabolism of polyamines	R-HSA-351202	9.867919e-01	0.006	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.870551e-01	0.006	0	0
Retinoid metabolism and transport	R-HSA-975634	9.870551e-01	0.006	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.872378e-01	0.006	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.872707e-01	0.006	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.872707e-01	0.006	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.876298e-01	0.005	0	0
Elastic fibre formation	R-HSA-1566948	9.876298e-01	0.005	0	0
Phospholipid metabolism	R-HSA-1483257	9.877201e-01	0.005	0	0
Alpha-oxidation of phytanate	R-HSA-389599	9.877608e-01	0.005	0	0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	9.877608e-01	0.005	0	0
Fertilization	R-HSA-1187000	9.877608e-01	0.005	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.877608e-01	0.005	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.880950e-01	0.005	0	0
Potential therapeutics for SARS	R-HSA-9679191	9.887179e-01	0.005	0	0
RAS processing	R-HSA-9648002	9.890637e-01	0.005	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.890637e-01	0.005	0	0
Mitochondrial protein import	R-HSA-1268020	9.892636e-01	0.005	0	0
Urea cycle	R-HSA-70635	9.893829e-01	0.005	0	0
Sphingolipid catabolism	R-HSA-9845614	9.893829e-01	0.005	0	0
Complex IV assembly	R-HSA-9864848	9.898232e-01	0.004	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.903432e-01	0.004	0	0
Interferon Signaling	R-HSA-913531	9.906509e-01	0.004	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	9.907901e-01	0.004	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.907901e-01	0.004	0	0
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	9.907901e-01	0.004	0	0
Insulin processing	R-HSA-264876	9.907901e-01	0.004	0	0
Iron uptake and transport	R-HSA-917937	9.912503e-01	0.004	0	0
Collagen formation	R-HSA-1474290	9.912627e-01	0.004	0	0
Insulin receptor recycling	R-HSA-77387	9.920108e-01	0.003	0	0
Prednisone ADME	R-HSA-9757110	9.920108e-01	0.003	0	0
Pyrimidine salvage	R-HSA-73614	9.920108e-01	0.003	0	0
Heme biosynthesis	R-HSA-189451	9.924592e-01	0.003	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.929466e-01	0.003	0	0
Pyruvate metabolism	R-HSA-70268	9.929972e-01	0.003	0	0
Thyroxine biosynthesis	R-HSA-209968	9.930698e-01	0.003	0	0
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.930698e-01	0.003	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.930698e-01	0.003	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.930698e-01	0.003	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.930698e-01	0.003	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.933426e-01	0.003	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.933426e-01	0.003	0	0
Leishmania phagocytosis	R-HSA-9664417	9.936239e-01	0.003	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.936239e-01	0.003	0	0
Parasite infection	R-HSA-9664407	9.936239e-01	0.003	0	0
G alpha (q) signalling events	R-HSA-416476	9.936733e-01	0.003	0	0
Defensins	R-HSA-1461973	9.941243e-01	0.003	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.942985e-01	0.002	0	0
PKR-mediated signaling	R-HSA-9833482	9.946938e-01	0.002	0	0
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	9.947855e-01	0.002	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	9.947855e-01	0.002	0	0
Signaling by GPCR	R-HSA-372790	9.949969e-01	0.002	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.951657e-01	0.002	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.952051e-01	0.002	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.953990e-01	0.002	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.954130e-01	0.002	0	0
HS-GAG degradation	R-HSA-2024096	9.954768e-01	0.002	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.956900e-01	0.002	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.960703e-01	0.002	0	0
Leishmania infection	R-HSA-9658195	9.961413e-01	0.002	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.961413e-01	0.002	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.963539e-01	0.002	1	1
Synthesis of PC	R-HSA-1483191	9.964454e-01	0.002	0	0
SLC transporter disorders	R-HSA-5619102	9.967798e-01	0.001	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.970480e-01	0.001	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.970480e-01	0.001	0	0
Signaling by NOTCH2	R-HSA-1980145	9.970480e-01	0.001	0	0
RSV-host interactions	R-HSA-9833110	9.971155e-01	0.001	0	0
Extracellular matrix organization	R-HSA-1474244	9.973298e-01	0.001	0	0
Formation of the cornified envelope	R-HSA-6809371	9.973741e-01	0.001	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.974117e-01	0.001	0	0
PERK regulates gene expression	R-HSA-381042	9.974395e-01	0.001	0	0
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.974395e-01	0.001	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.974395e-01	0.001	0	0
HS-GAG biosynthesis	R-HSA-2022928	9.977790e-01	0.001	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.977790e-01	0.001	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.980736e-01	0.001	0	0
Lysine catabolism	R-HSA-71064	9.980736e-01	0.001	0	0
Cholesterol biosynthesis	R-HSA-191273	9.980790e-01	0.001	0	0
Interleukin-10 signaling	R-HSA-6783783	9.980790e-01	0.001	0	0
Purine salvage	R-HSA-74217	9.983291e-01	0.001	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.983406e-01	0.001	0	0
Nicotinate metabolism	R-HSA-196807	9.983967e-01	0.001	0	0
Plasma lipoprotein clearance	R-HSA-8964043	9.985507e-01	0.001	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.985507e-01	0.001	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.985757e-01	0.001	0	0
Paracetamol ADME	R-HSA-9753281	9.987152e-01	0.001	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.987430e-01	0.001	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.987430e-01	0.001	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.988769e-01	0.000	0	0
Viral Infection Pathways	R-HSA-9824446	9.988935e-01	0.000	1	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.989097e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.989368e-01	0.000	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.989976e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.990032e-01	0.000	0	0
Metabolism of cofactors	R-HSA-8978934	9.990032e-01	0.000	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.991155e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.991155e-01	0.000	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.991798e-01	0.000	0	0
Peroxisomal protein import	R-HSA-9033241	9.992316e-01	0.000	0	0
Pyrimidine catabolism	R-HSA-73621	9.992886e-01	0.000	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.992886e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.993708e-01	0.000	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.993830e-01	0.000	0	0
Methylation	R-HSA-156581	9.993830e-01	0.000	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.993830e-01	0.000	0	0
Surfactant metabolism	R-HSA-5683826	9.993830e-01	0.000	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.993916e-01	0.000	0	0
Nucleotide salvage	R-HSA-8956321	9.994065e-01	0.000	0	0
Collagen degradation	R-HSA-1442490	9.994065e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.994159e-01	0.000	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.994649e-01	0.000	0	0
Complex I biogenesis	R-HSA-6799198	9.995419e-01	0.000	0	0
Xenobiotics	R-HSA-211981	9.995976e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.996138e-01	0.000	1	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.996509e-01	0.000	0	0
Metabolism of steroid hormones	R-HSA-196071	9.997276e-01	0.000	0	0
Azathioprine ADME	R-HSA-9748787	9.997374e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.997517e-01	0.000	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.997517e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.997873e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.997994e-01	0.000	0	0
tRNA processing	R-HSA-72306	9.998266e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.998464e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.998689e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.998689e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.998757e-01	0.000	0	0
Digestion	R-HSA-8935690	9.998883e-01	0.000	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999044e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999127e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999208e-01	0.000	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.999271e-01	0.000	0	0
tRNA Aminoacylation	R-HSA-379724	9.999368e-01	0.000	0	0
Glutathione conjugation	R-HSA-156590	9.999368e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999389e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999436e-01	0.000	0	0
Endogenous sterols	R-HSA-211976	9.999452e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999468e-01	0.000	0	0
Translation	R-HSA-72766	9.999520e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999567e-01	0.000	0	0
Digestion and absorption	R-HSA-8963743	9.999588e-01	0.000	0	0
Protein localization	R-HSA-9609507	9.999633e-01	0.000	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.999643e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999678e-01	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.999690e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999735e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999749e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.999767e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.999779e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999866e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.999901e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999945e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.999951e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.999952e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999961e-01	0.000	0	0
Post-translational protein modification	R-HSA-597592	9.999963e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999964e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999965e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999979e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999986e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.999987e-01	0.000	0	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999990e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999996e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999996e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999997e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999997e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999997e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.999997e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.999998e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999999e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999999e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999999e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999999e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999999e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000	0	0
Disease	R-HSA-1643685	1.000000e+00	0.000	1	0
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000e+00	0.000	1	0
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
M Phase	R-HSA-68886	1.110223e-16	15.955	0	0
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955	0	0
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955	0	0
Axon guidance	R-HSA-422475	1.110223e-16	15.955	1	0
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955	0	0
Cell Cycle, Mitotic	R-HSA-69278	1.110223e-16	15.955	0	0
Nervous system development	R-HSA-9675108	1.110223e-16	15.955	1	0
Cell Cycle Checkpoints	R-HSA-69620	7.771561e-16	15.109	0	0
Signaling by ROBO receptors	R-HSA-376176	6.328271e-15	14.199	1	0
Cellular response to heat stress	R-HSA-3371556	7.216450e-15	14.142	0	0
Mitotic Prometaphase	R-HSA-68877	6.834533e-13	12.165	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.323719e-12	11.878	0	0
Separation of Sister Chromatids	R-HSA-2467813	1.287304e-12	11.890	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.323719e-12	11.878	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	2.789102e-12	11.555	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	4.764633e-12	11.322	0	0
Cap-dependent Translation Initiation	R-HSA-72737	4.866885e-12	11.313	0	0
Eukaryotic Translation Initiation	R-HSA-72613	4.866885e-12	11.313	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.178036e-12	11.144	0	0
HSF1-dependent transactivation	R-HSA-3371571	1.172662e-11	10.931	0	0
Mitotic Anaphase	R-HSA-68882	1.897593e-11	10.722	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	2.119749e-11	10.674	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	2.212408e-11	10.655	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.247647e-11	10.648	0	0
G2/M Checkpoints	R-HSA-69481	2.472000e-11	10.607	0	0
Eukaryotic Translation Elongation	R-HSA-156842	2.797895e-11	10.553	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.140088e-11	10.289	0	0
Attenuation phase	R-HSA-3371568	5.991474e-11	10.222	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	5.941070e-11	10.226	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	7.945411e-11	10.100	0	0
Kinesins	R-HSA-983189	3.023506e-10	9.519	0	0
Peptide chain elongation	R-HSA-156902	3.795682e-10	9.421	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	5.403318e-10	9.267	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	5.403318e-10	9.267	0	0
Estrogen-dependent gene expression	R-HSA-9018519	7.986478e-10	9.098	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.098120e-10	9.092	0	0
Signal Transduction	R-HSA-162582	1.003126e-09	8.999	1	0
G2/M DNA damage checkpoint	R-HSA-69473	1.282052e-09	8.892	0	0
Aggrephagy	R-HSA-9646399	1.631397e-09	8.787	0	0
HSF1 activation	R-HSA-3371511	1.655813e-09	8.781	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.525045e-09	8.598	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.531511e-09	8.597	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.806681e-09	8.552	0	0
Cell-Cell communication	R-HSA-1500931	3.747121e-09	8.426	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	9.026415e-09	8.044	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	9.097607e-09	8.041	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.937873e-09	8.003	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.059099e-08	7.975	0	0
Metabolism of RNA	R-HSA-8953854	1.040640e-08	7.983	0	0
Eukaryotic Translation Termination	R-HSA-72764	1.180258e-08	7.928	0	0
Influenza Infection	R-HSA-168255	1.266474e-08	7.897	0	0
Post NMDA receptor activation events	R-HSA-438064	1.314310e-08	7.881	0	0
Mitotic Prophase	R-HSA-68875	1.374485e-08	7.862	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	1.547607e-08	7.810	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.596588e-08	7.797	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.935593e-08	7.713	0	0
Assembly of the pre-replicative complex	R-HSA-68867	1.973662e-08	7.705	0	0
Apoptotic execution phase	R-HSA-75153	2.035187e-08	7.691	1	0
Cell junction organization	R-HSA-446728	2.308191e-08	7.637	0	0
Membrane Trafficking	R-HSA-199991	2.373738e-08	7.625	0	0
Recycling pathway of L1	R-HSA-437239	2.820880e-08	7.550	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.992034e-08	7.524	0	0
Apoptosis	R-HSA-109581	3.392660e-08	7.469	1	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.739804e-08	7.427	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	3.750694e-08	7.426	0	0
G2/M Transition	R-HSA-69275	3.649909e-08	7.438	0	0
DNA Double Strand Break Response	R-HSA-5693606	3.847918e-08	7.415	0	0
DNA methylation	R-HSA-5334118	4.491712e-08	7.348	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	4.420896e-08	7.354	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	4.885459e-08	7.311	0	0
Mitotic G2-G2/M phases	R-HSA-453274	4.885459e-08	7.311	0	0
Diseases of programmed cell death	R-HSA-9645723	5.520929e-08	7.258	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	5.804117e-08	7.236	0	0
Translation initiation complex formation	R-HSA-72649	5.848644e-08	7.233	0	0
Nucleosome assembly	R-HSA-774815	6.340549e-08	7.198	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	6.340549e-08	7.198	0	0
Ribosome-associated quality control	R-HSA-9948299	7.588171e-08	7.120	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	7.608041e-08	7.119	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	8.349184e-08	7.078	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	8.349184e-08	7.078	0	0
Cellular Senescence	R-HSA-2559583	9.352547e-08	7.029	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	1.027248e-07	6.988	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.080991e-07	6.966	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.338760e-07	6.873	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	1.360460e-07	6.866	0	0
Selenocysteine synthesis	R-HSA-2408557	1.315590e-07	6.881	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.465934e-07	6.834	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.485855e-07	6.828	0	0
Meiotic synapsis	R-HSA-1221632	1.720989e-07	6.764	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.789103e-07	6.747	0	0
Viral mRNA Translation	R-HSA-192823	1.945897e-07	6.711	0	0
Meiosis	R-HSA-1500620	2.395567e-07	6.621	0	0
DNA Replication Pre-Initiation	R-HSA-69002	2.500927e-07	6.602	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	2.722463e-07	6.565	0	0
HDACs deacetylate histones	R-HSA-3214815	2.986376e-07	6.525	0	0
Amplification of signal from the kinetochores	R-HSA-141424	2.967622e-07	6.528	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.967622e-07	6.528	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.896466e-07	6.538	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.025571e-07	6.519	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.025571e-07	6.519	0	0
Cellular response to starvation	R-HSA-9711097	3.063096e-07	6.514	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	3.228284e-07	6.491	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.556167e-07	6.449	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	3.525158e-07	6.453	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	3.899644e-07	6.409	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	4.005173e-07	6.397	0	0
L1CAM interactions	R-HSA-373760	4.435492e-07	6.353	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	4.957090e-07	6.305	0	0
Signaling by ALK in cancer	R-HSA-9700206	4.957090e-07	6.305	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.716052e-07	6.326	0	0
Programmed Cell Death	R-HSA-5357801	5.520742e-07	6.258	1	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	5.533660e-07	6.257	0	0
Selective autophagy	R-HSA-9663891	5.533660e-07	6.257	0	0
Defective pyroptosis	R-HSA-9710421	5.887296e-07	6.230	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.117805e-07	6.213	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	7.139940e-07	6.146	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	7.777023e-07	6.109	0	0
HATs acetylate histones	R-HSA-3214847	7.802748e-07	6.108	0	0
PRC2 methylates histones and DNA	R-HSA-212300	8.571288e-07	6.067	0	0
Developmental Biology	R-HSA-1266738	9.499946e-07	6.022	1	0
Chaperone Mediated Autophagy	R-HSA-9613829	1.159623e-06	5.936	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	1.159623e-06	5.936	0	0
Adherens junctions interactions	R-HSA-418990	1.198118e-06	5.922	0	0
Meiotic recombination	R-HSA-912446	1.419874e-06	5.848	0	0
Autophagy	R-HSA-9612973	1.385457e-06	5.858	0	0
Chromatin modifying enzymes	R-HSA-3247509	1.602221e-06	5.795	0	0
Depurination	R-HSA-73927	1.608546e-06	5.794	0	0
HCMV Early Events	R-HSA-9609690	1.836956e-06	5.736	0	0
Chromatin organization	R-HSA-4839726	1.859655e-06	5.731	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	1.869072e-06	5.728	0	0
Reproduction	R-HSA-1474165	2.216347e-06	5.654	0	0
ESR-mediated signaling	R-HSA-8939211	2.232392e-06	5.651	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.270091e-06	5.644	0	0
Packaging Of Telomere Ends	R-HSA-171306	2.575537e-06	5.589	0	0
PKR-mediated signaling	R-HSA-9833482	2.561628e-06	5.591	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	3.059456e-06	5.514	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.166718e-06	5.499	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	3.728692e-06	5.428	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	3.873028e-06	5.412	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.091701e-06	5.388	0	0
Cell-cell junction organization	R-HSA-421270	4.736771e-06	5.325	0	0
Cleavage of the damaged purine	R-HSA-110331	4.848110e-06	5.314	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	5.175477e-06	5.286	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	5.721430e-06	5.242	0	0
rRNA processing	R-HSA-72312	5.699110e-06	5.244	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	5.552640e-06	5.256	0	0
Viral Infection Pathways	R-HSA-9824446	5.278694e-06	5.277	1	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.721430e-06	5.242	0	0
Cell-extracellular matrix interactions	R-HSA-446353	6.057211e-06	5.218	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	6.474899e-06	5.189	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	7.335616e-06	5.135	0	0
SARS-CoV-1 Infection	R-HSA-9678108	7.942117e-06	5.100	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	8.062862e-06	5.094	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	9.203899e-06	5.036	0	0
Gene Silencing by RNA	R-HSA-211000	9.904762e-06	5.004	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.083335e-05	4.965	1	1
Gap junction trafficking and regulation	R-HSA-157858	1.089152e-05	4.963	0	0
Gap junction trafficking	R-HSA-190828	1.122308e-05	4.950	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.122356e-05	4.950	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.353502e-05	4.869	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.461500e-05	4.835	0	0
Oncogenic MAPK signaling	R-HSA-6802957	1.887053e-05	4.724	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.917280e-05	4.717	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.976860e-05	4.704	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.189304e-05	4.660	0	0
Semaphorin interactions	R-HSA-373755	2.221843e-05	4.653	1	0
MHC class II antigen presentation	R-HSA-2132295	2.233961e-05	4.651	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	2.278931e-05	4.642	0	0
Regulation of endogenous retroelements	R-HSA-9842860	2.593507e-05	4.586	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.668675e-05	4.574	0	0
DNA Replication	R-HSA-69306	2.701446e-05	4.568	0	0
Macroautophagy	R-HSA-1632852	2.766054e-05	4.558	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	3.166939e-05	4.499	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	3.167367e-05	4.499	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.295321e-05	4.482	0	0
HCMV Infection	R-HSA-9609646	3.370813e-05	4.472	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	3.486563e-05	4.458	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	4.186237e-05	4.378	0	0
RNA Polymerase I Transcription	R-HSA-73864	4.300313e-05	4.366	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.000541e-05	4.301	0	0
Muscle contraction	R-HSA-397014	5.241625e-05	4.281	1	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	5.822073e-05	4.235	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	5.922953e-05	4.227	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.949077e-05	4.226	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	6.167991e-05	4.210	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	6.167991e-05	4.210	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	6.167991e-05	4.210	0	0
Signaling by RAS mutants	R-HSA-6802949	6.167991e-05	4.210	0	0
Signaling by RAF1 mutants	R-HSA-9656223	6.610632e-05	4.180	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	6.953855e-05	4.158	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	6.953855e-05	4.158	0	0
Homology Directed Repair	R-HSA-5693538	6.403035e-05	4.194	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	6.785808e-05	4.168	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	6.610632e-05	4.180	0	0
Amyloid fiber formation	R-HSA-977225	7.120073e-05	4.148	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	7.162623e-05	4.145	0	0
Vesicle-mediated transport	R-HSA-5653656	7.163549e-05	4.145	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.175215e-05	4.088	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	8.175215e-05	4.088	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	8.319725e-05	4.080	0	0
Depyrimidination	R-HSA-73928	8.319725e-05	4.080	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.379228e-05	4.077	0	0
Interleukin-12 signaling	R-HSA-9020591	8.379228e-05	4.077	1	0
Regulation of PTEN localization	R-HSA-8948747	9.293869e-05	4.032	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	9.999124e-05	4.000	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.040123e-04	3.983	0	0
AURKA Activation by TPX2	R-HSA-8854518	1.145043e-04	3.941	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.169388e-04	3.932	0	0
Hedgehog 'off' state	R-HSA-5610787	1.197123e-04	3.922	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.597646e-04	3.797	0	0
Signaling by WNT	R-HSA-195721	1.609612e-04	3.793	0	0
Signaling by NOTCH	R-HSA-157118	1.801469e-04	3.744	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.893034e-04	3.723	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.893034e-04	3.723	0	0
p75NTR signals via NF-kB	R-HSA-193639	1.859439e-04	3.731	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.910078e-04	3.719	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.859439e-04	3.731	0	0
Interleukin-12 family signaling	R-HSA-447115	2.093963e-04	3.679	1	0
Chromosome Maintenance	R-HSA-73886	2.126687e-04	3.672	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	2.252271e-04	3.647	0	0
Rap1 signalling	R-HSA-392517	2.311941e-04	3.636	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.380478e-04	3.623	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	2.518385e-04	3.599	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	2.532545e-04	3.596	0	0
Interferon Signaling	R-HSA-913531	3.084098e-04	3.511	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.096668e-04	3.509	0	0
Striated Muscle Contraction	R-HSA-390522	3.210644e-04	3.493	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	3.361627e-04	3.473	1	1
Late endosomal microautophagy	R-HSA-9615710	3.364023e-04	3.473	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	3.364023e-04	3.473	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	3.609537e-04	3.443	1	0
RAF activation	R-HSA-5673000	4.037630e-04	3.394	0	0
Gap junction assembly	R-HSA-190861	4.037630e-04	3.394	0	0
Co-inhibition by PD-1	R-HSA-389948	4.300575e-04	3.366	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	4.356046e-04	3.361	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	4.356046e-04	3.361	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.487788e-04	3.348	0	0
Protein ubiquitination	R-HSA-8852135	4.878990e-04	3.312	0	0
ISG15 antiviral mechanism	R-HSA-1169408	4.878990e-04	3.312	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.071688e-04	3.295	1	1
Ub-specific processing proteases	R-HSA-5689880	5.119494e-04	3.291	0	0
Signaling by Hippo	R-HSA-2028269	5.320564e-04	3.274	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.528653e-04	3.185	0	0
mRNA Splicing	R-HSA-72172	6.567096e-04	3.183	0	0
Metalloprotease DUBs	R-HSA-5689901	5.727480e-04	3.242	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	6.300176e-04	3.201	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.863508e-04	3.232	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	5.793827e-04	3.237	0	0
MAPK family signaling cascades	R-HSA-5683057	5.808341e-04	3.236	1	0
Death Receptor Signaling	R-HSA-73887	5.853750e-04	3.233	0	0
MAP2K and MAPK activation	R-HSA-5674135	6.774447e-04	3.169	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	7.041609e-04	3.152	1	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	7.338772e-04	3.134	0	0
Base Excision Repair	R-HSA-73884	7.558854e-04	3.122	0	0
Selenoamino acid metabolism	R-HSA-2408522	7.649663e-04	3.116	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.517768e-04	3.070	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	8.524680e-04	3.069	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	8.890547e-04	3.051	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	9.073039e-04	3.042	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.026936e-03	2.988	0	0
NF-kB is activated and signals survival	R-HSA-209560	1.026936e-03	2.988	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	1.062001e-03	2.974	0	0
Formation of annular gap junctions	R-HSA-196025	1.062001e-03	2.974	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	1.062001e-03	2.974	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.062001e-03	2.974	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.062001e-03	2.974	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	1.062001e-03	2.974	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.099440e-03	2.959	1	0
Centrosome maturation	R-HSA-380287	1.196469e-03	2.922	0	0
Neurodegenerative Diseases	R-HSA-8863678	1.254943e-03	2.901	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.254943e-03	2.901	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.287052e-03	2.890	0	0
Regulation of CDH1 Function	R-HSA-9764561	1.374216e-03	2.862	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.374216e-03	2.862	0	0
Glycolysis	R-HSA-70171	1.434570e-03	2.843	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	1.474646e-03	2.831	0	0
p75NTR recruits signalling complexes	R-HSA-209543	1.479386e-03	2.830	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	1.536740e-03	2.813	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	1.563113e-03	2.806	0	0
Sema4D in semaphorin signaling	R-HSA-400685	1.592584e-03	2.798	0	0
Signaling by VEGF	R-HSA-194138	1.629456e-03	2.788	1	0
Gap junction degradation	R-HSA-190873	1.643923e-03	2.784	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.660649e-03	2.780	0	0
Deubiquitination	R-HSA-5688426	1.760141e-03	2.754	0	0
Intracellular signaling by second messengers	R-HSA-9006925	1.822273e-03	2.739	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.904677e-03	2.720	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.920071e-03	2.717	0	0
Calmodulin induced events	R-HSA-111933	1.920071e-03	2.717	0	0
CaM pathway	R-HSA-111997	1.920071e-03	2.717	0	0
Smooth Muscle Contraction	R-HSA-445355	1.925009e-03	2.716	1	1
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.310691e-03	2.636	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.201416e-03	2.657	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	1.970482e-03	2.705	0	0
Ca-dependent events	R-HSA-111996	2.339039e-03	2.631	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	2.440960e-03	2.612	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	2.440960e-03	2.612	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.536961e-03	2.596	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	2.598452e-03	2.585	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	2.681815e-03	2.572	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	2.735196e-03	2.563	0	0
HCMV Late Events	R-HSA-9610379	2.791590e-03	2.554	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.838099e-03	2.547	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.885377e-03	2.540	0	0
Adaptive Immune System	R-HSA-1280218	2.923874e-03	2.534	1	0
NRAGE signals death through JNK	R-HSA-193648	3.001986e-03	2.523	0	0
RMTs methylate histone arginines	R-HSA-3214858	3.246226e-03	2.489	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.286560e-03	2.483	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.498309e-03	2.456	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.498309e-03	2.456	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	3.498309e-03	2.456	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.713518e-03	2.430	0	0
DAG and IP3 signaling	R-HSA-1489509	3.796877e-03	2.421	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	3.801357e-03	2.420	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	3.801357e-03	2.420	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	3.801357e-03	2.420	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	3.883188e-03	2.411	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	3.955577e-03	2.403	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.955577e-03	2.403	0	0
G alpha (12/13) signalling events	R-HSA-416482	4.012364e-03	2.397	0	0
SARS-CoV-2 Infection	R-HSA-9694516	4.206065e-03	2.376	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	4.264518e-03	2.370	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.264518e-03	2.370	1	1
S Phase	R-HSA-69242	4.501221e-03	2.347	0	0
PKMTs methylate histone lysines	R-HSA-3214841	4.571202e-03	2.340	0	0
Telomere Maintenance	R-HSA-157579	4.589897e-03	2.338	0	0
Nephrin family interactions	R-HSA-373753	4.720586e-03	2.326	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.863075e-03	2.313	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	4.863075e-03	2.313	0	0
DNA Repair	R-HSA-73894	4.878107e-03	2.312	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.938541e-03	2.306	0	0
Signaling by ERBB4	R-HSA-1236394	5.548045e-03	2.256	0	0
Chaperonin-mediated protein folding	R-HSA-390466	5.666178e-03	2.247	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	6.138813e-03	2.212	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	5.866584e-03	2.232	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	5.921107e-03	2.228	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	5.921107e-03	2.228	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.921107e-03	2.228	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.228997e-03	2.206	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	6.281709e-03	2.202	0	0
Neutrophil degranulation	R-HSA-6798695	6.730865e-03	2.172	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	6.138813e-03	2.212	0	0
Epigenetic regulation of gene expression	R-HSA-212165	5.937320e-03	2.226	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	6.801162e-03	2.167	0	0
Regulation of TP53 Activity	R-HSA-5633007	6.346720e-03	2.197	0	0
VLDLR internalisation and degradation	R-HSA-8866427	6.583280e-03	2.182	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	7.153850e-03	2.145	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.219392e-03	2.141	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	5.866584e-03	2.232	0	0
Cilium Assembly	R-HSA-5617833	6.458328e-03	2.190	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	6.289916e-03	2.201	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.217693e-03	2.142	0	0
Signaling by Hedgehog	R-HSA-5358351	6.177756e-03	2.209	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	7.279390e-03	2.138	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.340559e-03	2.134	0	0
Assembly Of The HIV Virion	R-HSA-175474	7.340559e-03	2.134	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.672821e-03	2.115	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	7.751331e-03	2.111	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	8.329507e-03	2.079	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	8.344322e-03	2.079	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	8.349211e-03	2.078	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	8.349211e-03	2.078	0	0
COPI-mediated anterograde transport	R-HSA-6807878	8.352670e-03	2.078	0	0
Translation	R-HSA-72766	8.593452e-03	2.066	0	0
Signaling by Interleukins	R-HSA-449147	8.608368e-03	2.065	1	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	8.799730e-03	2.056	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	8.799730e-03	2.056	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	8.944179e-03	2.048	0	0
mTORC1-mediated signalling	R-HSA-166208	9.002227e-03	2.046	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	9.137502e-03	2.039	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	9.137502e-03	2.039	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	9.675140e-03	2.014	0	0
Maturation of protein E	R-HSA-9694493	9.675140e-03	2.014	0	0
Maturation of protein E	R-HSA-9683683	9.675140e-03	2.014	0	0
Glucose metabolism	R-HSA-70326	9.950740e-03	2.002	0	0
Orc1 removal from chromatin	R-HSA-68949	1.010031e-02	1.996	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	1.019635e-02	1.992	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.019635e-02	1.992	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.027196e-02	1.988	0	0
Protein folding	R-HSA-391251	1.028896e-02	1.988	0	0
Switching of origins to a post-replicative state	R-HSA-69052	1.066276e-02	1.972	0	0
Nuclear import of Rev protein	R-HSA-180746	1.070568e-02	1.970	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.092952e-02	1.961	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.121938e-02	1.950	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.121938e-02	1.950	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.121938e-02	1.950	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.128074e-02	1.948	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.128074e-02	1.948	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	1.128074e-02	1.948	0	0
Josephin domain DUBs	R-HSA-5689877	1.147837e-02	1.940	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.147837e-02	1.940	0	0
Pexophagy	R-HSA-9664873	1.147837e-02	1.940	0	0
Signaling by ERBB2	R-HSA-1227986	1.172802e-02	1.931	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	1.190371e-02	1.924	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	1.218053e-02	1.914	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.247212e-02	1.904	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.270418e-02	1.896	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.298529e-02	1.887	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	1.298529e-02	1.887	0	0
PLC beta mediated events	R-HSA-112043	1.314104e-02	1.881	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	1.336257e-02	1.874	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.349379e-02	1.870	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.349379e-02	1.870	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.349379e-02	1.870	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.411487e-02	1.850	1	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.415570e-02	1.849	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.434988e-02	1.843	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.434988e-02	1.843	0	0
Spry regulation of FGF signaling	R-HSA-1295596	1.434988e-02	1.843	0	0
Regulation of TP53 Degradation	R-HSA-6804757	1.444476e-02	1.840	0	0
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.816463e-02	1.741	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	1.567369e-02	1.805	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	1.567369e-02	1.805	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	1.853570e-02	1.732	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.522544e-02	1.817	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.522544e-02	1.817	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.664395e-02	1.779	0	0
Signaling by EGFR	R-HSA-177929	1.629746e-02	1.788	0	0
MTOR signalling	R-HSA-165159	1.541779e-02	1.812	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	1.827012e-02	1.738	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.827012e-02	1.738	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.978089e-02	1.704	0	0
Negative regulation of MET activity	R-HSA-6807004	1.552511e-02	1.809	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.685064e-02	1.773	0	0
HIV Life Cycle	R-HSA-162587	1.518504e-02	1.819	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.635886e-02	1.786	0	0
Signaling by PTK6	R-HSA-8848021	1.635886e-02	1.786	0	0
Immune System	R-HSA-168256	1.752933e-02	1.756	1	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.017980e-02	1.695	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	2.017980e-02	1.695	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	2.053835e-02	1.687	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.053835e-02	1.687	0	0
Activation of ATR in response to replication stress	R-HSA-176187	2.053835e-02	1.687	0	0
SARS-CoV Infections	R-HSA-9679506	2.100774e-02	1.678	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	2.175309e-02	1.662	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.213939e-02	1.655	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	2.213939e-02	1.655	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	2.244964e-02	1.649	0	0
Metabolism of non-coding RNA	R-HSA-194441	2.258030e-02	1.646	0	0
snRNP Assembly	R-HSA-191859	2.258030e-02	1.646	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	2.266078e-02	1.645	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.364451e-02	1.626	0	0
Signaling by NOTCH4	R-HSA-9013694	2.393402e-02	1.621	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.427191e-02	1.615	0	0
G-protein mediated events	R-HSA-112040	2.455995e-02	1.610	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.472545e-02	1.607	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	2.472545e-02	1.607	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.502927e-02	1.602	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.502927e-02	1.602	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.502927e-02	1.602	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.502927e-02	1.602	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.502927e-02	1.602	0	0
Repression of WNT target genes	R-HSA-4641265	2.539200e-02	1.595	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	2.660686e-02	1.575	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	2.661474e-02	1.575	0	0
Specification of primordial germ cells	R-HSA-9827857	2.693322e-02	1.570	0	0
Dual Incision in GG-NER	R-HSA-5696400	2.707158e-02	1.567	0	0
Signaling by NOTCH2	R-HSA-1980145	2.707158e-02	1.567	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.732162e-02	1.563	0	0
Modulation by Mtb of host immune system	R-HSA-9637628	2.732162e-02	1.563	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.795765e-02	1.553	1	1
Transcriptional Regulation by VENTX	R-HSA-8853884	2.795765e-02	1.553	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.824532e-02	1.549	0	0
RAF/MAP kinase cascade	R-HSA-5673001	2.834057e-02	1.548	0	0
Signaling by NOTCH1	R-HSA-1980143	2.867196e-02	1.543	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	2.883007e-02	1.540	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.883007e-02	1.540	0	0
tRNA processing in the nucleus	R-HSA-6784531	3.050589e-02	1.516	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	3.083429e-02	1.511	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.083429e-02	1.511	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	3.171117e-02	1.499	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.171117e-02	1.499	0	0
Ephrin signaling	R-HSA-3928664	3.236809e-02	1.490	1	1
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.236809e-02	1.490	0	0
Activation of BH3-only proteins	R-HSA-114452	3.373283e-02	1.472	0	0
Ion homeostasis	R-HSA-5578775	3.444541e-02	1.463	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.444541e-02	1.463	0	0
RET signaling	R-HSA-8853659	3.494636e-02	1.457	0	0
GP1b-IX-V activation signalling	R-HSA-430116	3.579498e-02	1.446	0	0
Unwinding of DNA	R-HSA-176974	3.579498e-02	1.446	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	3.580464e-02	1.446	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	3.580464e-02	1.446	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.580464e-02	1.446	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	3.580464e-02	1.446	0	0
PIP3 activates AKT signaling	R-HSA-1257604	3.668847e-02	1.435	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.796892e-02	1.421	0	0
Defective Base Excision Repair Associated with OGG1	R-HSA-9656249	3.824327e-02	1.417	0	0
Breakdown of the nuclear lamina	R-HSA-352238	3.824327e-02	1.417	0	0
Regulation of signaling by CBL	R-HSA-912631	3.846916e-02	1.415	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	3.846916e-02	1.415	0	0
Translesion Synthesis by POLH	R-HSA-110320	3.846916e-02	1.415	0	0
STING mediated induction of host immune responses	R-HSA-1834941	3.846916e-02	1.415	0	0
EGFR downregulation	R-HSA-182971	3.855957e-02	1.414	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	3.855957e-02	1.414	1	1
Budding and maturation of HIV virion	R-HSA-162588	3.855957e-02	1.414	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	3.855957e-02	1.414	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	3.855957e-02	1.414	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	3.868560e-02	1.412	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.893293e-02	1.410	0	0
Ovarian tumor domain proteases	R-HSA-5689896	3.942033e-02	1.404	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.942033e-02	1.404	0	0
Developmental Cell Lineages	R-HSA-9734767	3.984558e-02	1.400	0	0
Synthesis of DNA	R-HSA-69239	4.037116e-02	1.394	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	4.967037e-02	1.304	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	4.967037e-02	1.304	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	4.967037e-02	1.304	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	4.967037e-02	1.304	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	4.967037e-02	1.304	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.562226e-02	1.341	0	0
DCC mediated attractive signaling	R-HSA-418885	4.707903e-02	1.327	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	4.707903e-02	1.327	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	4.707903e-02	1.327	0	0
Translesion synthesis by POLI	R-HSA-5656121	5.616093e-02	1.251	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	5.616093e-02	1.251	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.518967e-02	1.258	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	5.518967e-02	1.258	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	6.238551e-02	1.205	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	5.379967e-02	1.269	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	5.926596e-02	1.227	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	5.204886e-02	1.284	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.231251e-02	1.205	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	5.647461e-02	1.248	0	0
IRE1alpha activates chaperones	R-HSA-381070	5.931316e-02	1.227	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	5.274405e-02	1.278	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	4.298647e-02	1.367	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	5.204886e-02	1.284	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	4.707903e-02	1.327	1	1
Translesion synthesis by REV1	R-HSA-110312	4.707903e-02	1.327	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	4.707903e-02	1.327	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	5.616093e-02	1.251	0	0
Long-term potentiation	R-HSA-9620244	4.212962e-02	1.375	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	4.949782e-02	1.305	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	5.379967e-02	1.269	0	0
Interleukin-1 signaling	R-HSA-9020702	4.278644e-02	1.369	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.000706e-02	1.222	0	0
Regulated Necrosis	R-HSA-5218859	5.206851e-02	1.283	0	0
Protein methylation	R-HSA-8876725	4.707903e-02	1.327	0	0
UCH proteinases	R-HSA-5689603	5.356457e-02	1.271	0	0
Formation of definitive endoderm	R-HSA-9823730	4.525631e-02	1.344	0	0
Glycogen metabolism	R-HSA-8982491	5.511974e-02	1.259	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	4.967037e-02	1.304	0	0
Protein hydroxylation	R-HSA-9629569	4.525631e-02	1.344	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	6.238551e-02	1.205	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	6.238551e-02	1.205	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.959737e-02	1.225	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.959737e-02	1.225	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.959737e-02	1.225	0	0
Opioid Signalling	R-HSA-111885	5.242798e-02	1.280	0	0
TCR signaling	R-HSA-202403	4.928004e-02	1.307	1	0
Transcriptional regulation by RUNX3	R-HSA-8878159	5.576998e-02	1.254	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.616093e-02	1.251	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	5.518967e-02	1.258	0	0
HIV Infection	R-HSA-162906	5.255705e-02	1.279	1	0
Signaling by TGFB family members	R-HSA-9006936	4.732048e-02	1.325	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	5.379967e-02	1.269	0	0
Hemostasis	R-HSA-109582	4.325807e-02	1.364	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	5.616093e-02	1.251	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	5.680270e-02	1.246	0	0
Negative regulation of FLT3	R-HSA-9706369	5.616093e-02	1.251	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	6.114025e-02	1.214	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	5.984938e-02	1.223	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	5.274405e-02	1.278	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	4.426751e-02	1.354	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	6.094135e-02	1.215	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	6.256718e-02	1.204	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	6.256718e-02	1.204	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	6.256718e-02	1.204	0	0
Regulation of TP53 Expression	R-HSA-6804754	6.365568e-02	1.196	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	6.450453e-02	1.190	0	0
Intraflagellar transport	R-HSA-5620924	6.508150e-02	1.187	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	6.575480e-02	1.182	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.602675e-02	1.180	0	0
Translesion synthesis by POLK	R-HSA-5655862	6.618010e-02	1.179	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	6.618010e-02	1.179	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.618010e-02	1.179	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	6.760146e-02	1.170	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	6.790744e-02	1.168	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	6.790744e-02	1.168	0	0
Activation of RAC1	R-HSA-428540	6.931461e-02	1.159	1	1
Signaling by GSK3beta mutants	R-HSA-5339716	6.931461e-02	1.159	0	0
Regulation of Apoptosis	R-HSA-169911	6.951435e-02	1.158	1	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	6.985174e-02	1.156	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	7.051700e-02	1.152	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	7.051700e-02	1.152	0	0
DARPP-32 events	R-HSA-180024	7.051700e-02	1.152	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.051700e-02	1.152	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.111875e-02	1.148	0	0
DNA Damage Bypass	R-HSA-73893	7.125054e-02	1.147	0	0
Degradation of CDH1	R-HSA-9766229	7.125054e-02	1.147	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.171944e-02	1.144	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	7.196159e-02	1.143	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	7.439703e-02	1.128	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.608342e-02	1.119	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	7.617946e-02	1.118	0	0
FLT3 signaling in disease	R-HSA-9682385	7.712137e-02	1.113	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	7.712847e-02	1.113	0	0
Glycogen storage diseases	R-HSA-3229121	7.712847e-02	1.113	0	0
Host Interactions of HIV factors	R-HSA-162909	7.858227e-02	1.105	1	0
Activation of the pre-replicative complex	R-HSA-68962	7.904043e-02	1.102	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	7.904043e-02	1.102	0	0
Dual incision in TC-NER	R-HSA-6782135	8.004103e-02	1.097	0	0
ER-Phagosome pathway	R-HSA-1236974	8.245543e-02	1.084	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.311787e-02	1.080	0	0
Disorders of Nervous System Development	R-HSA-9697154	8.311787e-02	1.080	0	0
Pervasive developmental disorders	R-HSA-9005895	8.311787e-02	1.080	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	8.311787e-02	1.080	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	8.311787e-02	1.080	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	8.311787e-02	1.080	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	8.311787e-02	1.080	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	8.311787e-02	1.080	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	8.311787e-02	1.080	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	8.311787e-02	1.080	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	8.311787e-02	1.080	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	8.311787e-02	1.080	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	8.311787e-02	1.080	0	0
IRAK1 recruits IKK complex	R-HSA-937039	8.311787e-02	1.080	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.311787e-02	1.080	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	8.390069e-02	1.076	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.520721e-02	1.070	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	8.679521e-02	1.062	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.813538e-02	1.055	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.817810e-02	1.055	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.817810e-02	1.055	0	0
Apoptotic factor-mediated response	R-HSA-111471	8.898903e-02	1.051	0	0
PKA activation	R-HSA-163615	8.898903e-02	1.051	0	0
Polo-like kinase mediated events	R-HSA-156711	8.898903e-02	1.051	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	8.898903e-02	1.051	0	0
PKA activation in glucagon signalling	R-HSA-164378	8.898903e-02	1.051	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.190267e-02	1.037	0	0
mRNA 3'-end processing	R-HSA-72187	9.190267e-02	1.037	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.190267e-02	1.037	0	0
MET interacts with TNS proteins	R-HSA-8875513	9.318025e-02	1.031	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	9.318025e-02	1.031	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	9.318025e-02	1.031	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	9.407686e-02	1.027	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.528214e-02	1.021	0	0
Toll-like Receptor Cascades	R-HSA-168898	9.639392e-02	1.016	0	0
Nucleotide Excision Repair	R-HSA-5696398	9.676513e-02	1.014	0	0
Defective OGG1 Substrate Binding	R-HSA-9656255	9.694493e-02	1.013	0	0
Defective OGG1 Localization	R-HSA-9657050	9.694493e-02	1.013	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	9.694493e-02	1.013	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	9.694493e-02	1.013	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.735392e-02	1.012	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	9.735392e-02	1.012	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.735392e-02	1.012	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.735392e-02	1.012	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.779653e-02	1.010	0	0
DNA strand elongation	R-HSA-69190	9.779653e-02	1.010	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	9.779653e-02	1.010	0	0
Formation of axial mesoderm	R-HSA-9796292	9.815650e-02	1.008	0	0
Frs2-mediated activation	R-HSA-170968	9.815650e-02	1.008	0	0
Interleukin-6 signaling	R-HSA-1059683	9.815650e-02	1.008	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	9.950357e-02	1.002	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	9.950357e-02	1.002	0	0
MAP kinase activation	R-HSA-450294	1.006250e-01	0.997	0	0
Interleukin-7 signaling	R-HSA-1266695	1.008172e-01	0.996	0	0
Transmission across Chemical Synapses	R-HSA-112315	1.018511e-01	0.992	0	0
Infectious disease	R-HSA-5663205	1.021791e-01	0.991	1	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.022143e-01	0.990	0	0
Stabilization of p53	R-HSA-69541	1.028065e-01	0.988	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.038839e-01	0.983	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.039214e-01	0.983	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.074607e-01	0.969	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.075091e-01	0.969	0	0
Integrin signaling	R-HSA-354192	1.080153e-01	0.967	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.080153e-01	0.967	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.080153e-01	0.967	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.080153e-01	0.967	0	0
Regulation of necroptotic cell death	R-HSA-5675482	1.080153e-01	0.967	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.080153e-01	0.967	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	1.095937e-01	0.960	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	1.115351e-01	0.953	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.123100e-01	0.950	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	1.123100e-01	0.950	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	1.123100e-01	0.950	0	0
Myogenesis	R-HSA-525793	1.125106e-01	0.949	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.125106e-01	0.949	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.131542e-01	0.946	0	0
Antigen processing-Cross presentation	R-HSA-1236975	1.137967e-01	0.944	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	1.143612e-01	0.942	0	0
Defective OGG1 Substrate Processing	R-HSA-9656256	1.844967e-01	0.734	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.844967e-01	0.734	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.844967e-01	0.734	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.844967e-01	0.734	1	1
Diseases of Telomere Maintenance	R-HSA-9673013	1.844967e-01	0.734	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.844967e-01	0.734	0	0
TICAM1 deficiency - HSE	R-HSA-5602566	1.844967e-01	0.734	0	0
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	1.844967e-01	0.734	0	0
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	1.844967e-01	0.734	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.844967e-01	0.734	0	0
Regulation of gap junction activity	R-HSA-191650	1.257818e-01	0.900	0	0
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.257818e-01	0.900	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	1.257818e-01	0.900	0	0
IRS activation	R-HSA-74713	1.605872e-01	0.794	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.256119e-01	0.901	0	0
Lipophagy	R-HSA-9613354	1.256119e-01	0.901	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	1.256119e-01	0.901	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.968632e-01	0.706	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	1.968632e-01	0.706	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	1.968632e-01	0.706	0	0
PI3K/AKT activation	R-HSA-198203	1.487574e-01	0.828	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	1.487574e-01	0.828	0	0
2-LTR circle formation	R-HSA-164843	1.487574e-01	0.828	0	0
Folding of actin by CCT/TriC	R-HSA-390450	1.487574e-01	0.828	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.731403e-01	0.762	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.731403e-01	0.762	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.731403e-01	0.762	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.316519e-01	0.881	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	1.316519e-01	0.881	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.153384e-01	0.938	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	1.691312e-01	0.772	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	1.691312e-01	0.772	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.247646e-01	0.648	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.248585e-01	0.904	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.891262e-01	0.723	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.891262e-01	0.723	0	0
Pyroptosis	R-HSA-5620971	1.378358e-01	0.861	0	0
GAB1 signalosome	R-HSA-180292	2.098237e-01	0.678	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	1.514138e-01	0.820	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.946056e-01	0.711	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	1.946056e-01	0.711	0	0
Trafficking of AMPA receptors	R-HSA-399719	1.802420e-01	0.744	0	0
Regulation of RAS by GAPs	R-HSA-5658442	1.436510e-01	0.843	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	1.648186e-01	0.783	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.759262e-01	0.755	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.727237e-01	0.763	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	1.791379e-01	0.747	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	2.269058e-01	0.644	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.223211e-01	0.653	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.785454e-01	0.748	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.655607e-01	0.781	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	1.985456e-01	0.702	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.247646e-01	0.648	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.514138e-01	0.820	0	0
TGFBR3 expression	R-HSA-9839394	2.123382e-01	0.673	0	0
Integration of provirus	R-HSA-162592	1.985456e-01	0.702	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.655607e-01	0.781	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.247623e-01	0.904	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	1.985456e-01	0.702	0	0
Disorders of Developmental Biology	R-HSA-9675151	1.691312e-01	0.772	0	0
Regulation of CDH11 function	R-HSA-9762292	1.487574e-01	0.828	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	1.785454e-01	0.748	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.891812e-01	0.723	0	0
Regulation of mitotic cell cycle	R-HSA-453276	1.891812e-01	0.723	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.449423e-01	0.839	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.507410e-01	0.822	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	1.297553e-01	0.887	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	1.891262e-01	0.723	0	0
PTEN Regulation	R-HSA-6807070	1.256087e-01	0.901	0	0
Prolonged ERK activation events	R-HSA-169893	1.499402e-01	0.824	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	1.222724e-01	0.913	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.222724e-01	0.913	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	1.222724e-01	0.913	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	1.418884e-01	0.848	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	1.418884e-01	0.848	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.388028e-01	0.858	0	0
Diseases of Immune System	R-HSA-5260271	2.079046e-01	0.682	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	2.079046e-01	0.682	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.347971e-01	0.870	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	1.909830e-01	0.719	0	0
Ca2+ pathway	R-HSA-4086398	2.102120e-01	0.677	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.421499e-01	0.847	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	1.713976e-01	0.766	1	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.421499e-01	0.847	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.625843e-01	0.789	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.790424e-01	0.747	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	1.702205e-01	0.769	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.625843e-01	0.789	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.300770e-01	0.886	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.222724e-01	0.913	0	0
Degradation of DVL	R-HSA-4641258	1.669744e-01	0.777	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	1.548017e-01	0.810	0	0
TNF signaling	R-HSA-75893	1.244300e-01	0.905	0	0
Mitophagy	R-HSA-5205647	1.300770e-01	0.886	0	0
Signaling by FGFR2	R-HSA-5654738	1.938663e-01	0.712	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.449423e-01	0.839	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	1.300770e-01	0.886	0	0
Signaling by MET	R-HSA-6806834	1.216893e-01	0.915	0	0
Glycogen synthesis	R-HSA-3322077	1.153384e-01	0.938	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.303150e-01	0.638	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.303150e-01	0.638	0	0
Platelet degranulation	R-HSA-114608	1.447674e-01	0.839	0	0
Signaling by FGFR4	R-HSA-5654743	1.548017e-01	0.810	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	1.785454e-01	0.748	0	0
Ion transport by P-type ATPases	R-HSA-936837	1.240560e-01	0.906	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	1.942050e-01	0.712	0	0
Signaling by FGFR3	R-HSA-5654741	1.785454e-01	0.748	0	0
Inhibition of PKR	R-HSA-169131	1.844967e-01	0.734	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	1.256119e-01	0.901	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	1.968632e-01	0.706	0	0
Bicarbonate transporters	R-HSA-425381	1.731403e-01	0.762	0	0
Signaling by APC mutants	R-HSA-4839744	1.731403e-01	0.762	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.985456e-01	0.702	0	0
Signaling by AMER1 mutants	R-HSA-4839748	1.985456e-01	0.702	0	0
Signaling by AXIN mutants	R-HSA-4839735	1.985456e-01	0.702	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	1.891262e-01	0.723	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	1.541948e-01	0.812	0	0
Degradation of AXIN	R-HSA-4641257	1.669744e-01	0.777	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	1.297553e-01	0.887	0	0
Interleukin-17 signaling	R-HSA-448424	1.790424e-01	0.747	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.110573e-01	0.676	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	2.303150e-01	0.638	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	1.256119e-01	0.901	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	1.833205e-01	0.737	0	0
Oncogene Induced Senescence	R-HSA-2559585	1.418884e-01	0.848	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.802033e-01	0.744	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.727237e-01	0.763	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.909007e-01	0.719	0	0
Interleukin-1 processing	R-HSA-448706	1.256119e-01	0.901	0	0
Vpu mediated degradation of CD4	R-HSA-180534	1.187803e-01	0.925	0	0
Syndecan interactions	R-HSA-3000170	1.774229e-01	0.751	0	0
Calnexin/calreticulin cycle	R-HSA-901042	1.300770e-01	0.886	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.256119e-01	0.901	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.512615e-01	0.820	0	0
Signal transduction by L1	R-HSA-445144	1.153384e-01	0.938	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.487574e-01	0.828	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	1.256119e-01	0.901	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.968632e-01	0.706	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	1.297553e-01	0.887	0	0
Regulation of gene expression in beta cells	R-HSA-210745	1.514138e-01	0.820	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	2.271119e-01	0.644	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	2.053647e-01	0.687	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	1.221558e-01	0.913	0	0
Disease	R-HSA-1643685	1.435971e-01	0.843	1	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.223805e-01	0.912	0	0
Signaling by NOTCH3	R-HSA-9012852	1.157710e-01	0.936	0	0
G1/S Transition	R-HSA-69206	1.322634e-01	0.879	0	0
Generation of second messenger molecules	R-HSA-202433	2.079046e-01	0.682	1	1
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.356783e-01	0.867	0	0
Diseases of Base Excision Repair	R-HSA-9605308	1.968632e-01	0.706	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.230858e-01	0.910	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	1.968632e-01	0.706	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	2.247646e-01	0.648	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.449423e-01	0.839	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	1.790424e-01	0.747	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.111728e-01	0.675	0	0
Triglyceride catabolism	R-HSA-163560	1.541948e-01	0.812	0	0
Plasma lipoprotein clearance	R-HSA-8964043	1.938558e-01	0.713	0	0
MITF-M-dependent gene expression	R-HSA-9856651	2.025967e-01	0.693	0	0
Co-stimulation by CD28	R-HSA-389356	2.168894e-01	0.664	1	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.968632e-01	0.706	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.449423e-01	0.839	0	0
Translation of Structural Proteins	R-HSA-9683701	1.326836e-01	0.877	0	0
Regulation of BACH1 activity	R-HSA-9708530	1.499402e-01	0.824	0	0
Germ layer formation at gastrulation	R-HSA-9754189	2.311216e-01	0.636	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.339981e-01	0.631	0	0
G2/M DNA replication checkpoint	R-HSA-69478	2.339981e-01	0.631	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	2.339981e-01	0.631	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	2.339981e-01	0.631	0	0
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	2.339981e-01	0.631	0	0
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	2.339981e-01	0.631	0	0
Nef and signal transduction	R-HSA-164944	2.339981e-01	0.631	1	1
Degradation of CRY and PER proteins	R-HSA-9932298	2.370754e-01	0.625	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	2.370754e-01	0.625	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	2.403587e-01	0.619	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.435427e-01	0.613	0	0
Neuronal System	R-HSA-112316	2.484129e-01	0.605	0	0
Cristae formation	R-HSA-8949613	2.492078e-01	0.603	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	2.492078e-01	0.603	0	0
Cardiac conduction	R-HSA-5576891	2.494599e-01	0.603	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.515986e-01	0.599	0	0
Maturation of nucleoprotein	R-HSA-9683610	2.515986e-01	0.599	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	2.515986e-01	0.599	1	1
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	2.521370e-01	0.598	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	2.526088e-01	0.598	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.529184e-01	0.597	0	0
Signaling by NTRKs	R-HSA-166520	2.568782e-01	0.590	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	2.579965e-01	0.588	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	2.579965e-01	0.588	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	2.620359e-01	0.582	0	0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	2.635649e-01	0.579	0	0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	2.635649e-01	0.579	0	0
MyD88 deficiency (TLR5)	R-HSA-5602680	2.635649e-01	0.579	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.635649e-01	0.579	0	0
TRAF3 deficiency - HSE	R-HSA-5602571	2.635649e-01	0.579	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	2.635649e-01	0.579	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	2.635649e-01	0.579	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.635649e-01	0.579	0	0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.635649e-01	0.579	0	0
Transport of connexins along the secretory pathway	R-HSA-190827	2.635649e-01	0.579	0	0
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.635649e-01	0.579	0	0
Manipulation of host energy metabolism	R-HSA-9636667	2.635649e-01	0.579	0	0
Oligomerization of connexins into connexons	R-HSA-190704	2.635649e-01	0.579	0	0
PCP/CE pathway	R-HSA-4086400	2.666520e-01	0.574	0	0
MECP2 regulates transcription factors	R-HSA-9022707	2.714849e-01	0.566	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	2.714849e-01	0.566	0	0
SOS-mediated signalling	R-HSA-112412	2.714849e-01	0.566	0	0
Recycling of eIF2:GDP	R-HSA-72731	2.714849e-01	0.566	0	0
CHL1 interactions	R-HSA-447041	2.714849e-01	0.566	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.714849e-01	0.566	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.714849e-01	0.566	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.751143e-01	0.560	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	2.751143e-01	0.560	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	2.753205e-01	0.560	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	2.773623e-01	0.557	0	0
Retrograde neurotrophin signalling	R-HSA-177504	2.788604e-01	0.555	0	0
CRMPs in Sema3A signaling	R-HSA-399956	2.788604e-01	0.555	0	0
Zinc transporters	R-HSA-435354	2.788604e-01	0.555	0	0
HDL assembly	R-HSA-8963896	2.788604e-01	0.555	0	0
Netrin-1 signaling	R-HSA-373752	2.830561e-01	0.548	0	0
EPHB-mediated forward signaling	R-HSA-3928662	2.830561e-01	0.548	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.830561e-01	0.548	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.875356e-01	0.541	0	0
Hedgehog 'on' state	R-HSA-5632684	2.899969e-01	0.538	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.976125e-01	0.526	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.976125e-01	0.526	0	0
Signaling by PDGFR in disease	R-HSA-9671555	2.976125e-01	0.526	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	2.988500e-01	0.525	0	0
Ion channel transport	R-HSA-983712	2.990537e-01	0.524	0	0
RSV-host interactions	R-HSA-9833110	3.000393e-01	0.523	0	0
Integration of energy metabolism	R-HSA-163685	3.033336e-01	0.518	0	0
Formation of the anterior neural plate	R-HSA-9823739	3.063760e-01	0.514	0	0
Gene expression (Transcription)	R-HSA-74160	3.082951e-01	0.511	0	0
Type I hemidesmosome assembly	R-HSA-446107	3.089065e-01	0.510	0	0
Adrenoceptors	R-HSA-390696	3.089065e-01	0.510	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	3.089065e-01	0.510	0	0
MET promotes cell motility	R-HSA-8875878	3.121729e-01	0.506	0	0
Signaling by TGFBR3	R-HSA-9839373	3.148240e-01	0.502	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	3.148240e-01	0.502	0	0
FGFR2 alternative splicing	R-HSA-6803529	3.203195e-01	0.494	0	0
Notch-HLH transcription pathway	R-HSA-350054	3.203195e-01	0.494	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.203195e-01	0.494	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	3.298430e-01	0.482	0	0
Cellular response to hypoxia	R-HSA-1234174	3.301439e-01	0.481	0	0
Signaling by FGFR1	R-HSA-5654736	3.309078e-01	0.480	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	3.309078e-01	0.480	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	3.309463e-01	0.480	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	3.309463e-01	0.480	0	0
Phosphorylation of the APC/C	R-HSA-176412	3.339855e-01	0.476	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	3.339855e-01	0.476	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.339855e-01	0.476	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	3.349712e-01	0.475	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.349712e-01	0.475	1	1
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	3.349712e-01	0.475	0	0
Defective ALG9 causes CDG-1l	R-HSA-4720454	3.349712e-01	0.475	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	3.349712e-01	0.475	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	3.349712e-01	0.475	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.349712e-01	0.475	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	3.349712e-01	0.475	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	3.349712e-01	0.475	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	3.349712e-01	0.475	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.349712e-01	0.475	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	3.349712e-01	0.475	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	3.349712e-01	0.475	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	3.349712e-01	0.475	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.349712e-01	0.475	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	3.349712e-01	0.475	0	0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	3.349712e-01	0.475	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	3.349712e-01	0.475	0	0
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.349712e-01	0.475	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.349712e-01	0.475	0	0
Interleukin-33 signaling	R-HSA-9014843	3.349712e-01	0.475	0	0
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.349712e-01	0.475	0	0
DSCAM interactions	R-HSA-376172	3.349712e-01	0.475	0	0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	3.349712e-01	0.475	0	0
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.349712e-01	0.475	0	0
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	3.349712e-01	0.475	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	3.431465e-01	0.465	0	0
ALK mutants bind TKIs	R-HSA-9700645	3.459235e-01	0.461	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	3.459235e-01	0.461	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.459235e-01	0.461	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	3.459235e-01	0.461	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.459235e-01	0.461	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	3.459235e-01	0.461	0	0
ARMS-mediated activation	R-HSA-170984	3.459235e-01	0.461	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.459235e-01	0.461	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	3.459235e-01	0.461	0	0
Signaling by WNT in cancer	R-HSA-4791275	3.466916e-01	0.460	0	0
GPER1 signaling	R-HSA-9634597	3.471854e-01	0.459	0	0
Gluconeogenesis	R-HSA-70263	3.471854e-01	0.459	0	0
NGF-stimulated transcription	R-HSA-9031628	3.471854e-01	0.459	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.615436e-01	0.442	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	3.615436e-01	0.442	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	3.615436e-01	0.442	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	3.615436e-01	0.442	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	3.615436e-01	0.442	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	3.615436e-01	0.442	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.615436e-01	0.442	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.615436e-01	0.442	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	3.655053e-01	0.437	0	0
FLT3 Signaling	R-HSA-9607240	3.655053e-01	0.437	0	0
Deadenylation of mRNA	R-HSA-429947	3.660092e-01	0.437	0	0
Interleukin-6 family signaling	R-HSA-6783589	3.660092e-01	0.437	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.666201e-01	0.436	0	0
G-protein beta:gamma signalling	R-HSA-397795	3.666201e-01	0.436	0	0
Cardiogenesis	R-HSA-9733709	3.666201e-01	0.436	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	3.666201e-01	0.436	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.724655e-01	0.429	0	0
Interleukin-1 family signaling	R-HSA-446652	3.754118e-01	0.425	0	0
Triglyceride metabolism	R-HSA-8979227	3.762027e-01	0.425	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.822627e-01	0.418	0	0
MAPK3 (ERK1) activation	R-HSA-110056	3.822627e-01	0.418	0	0
Regulation of the apoptosome activity	R-HSA-9627069	3.822627e-01	0.418	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	3.822627e-01	0.418	0	0
Formation of apoptosome	R-HSA-111458	3.822627e-01	0.418	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	3.822627e-01	0.418	0	0
Signal attenuation	R-HSA-74749	3.822627e-01	0.418	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.822627e-01	0.418	0	0
Signaling by Leptin	R-HSA-2586552	3.822627e-01	0.418	0	0
RNA Polymerase II Transcription	R-HSA-73857	3.822830e-01	0.418	0	0
HDMs demethylate histones	R-HSA-3214842	3.888287e-01	0.410	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	3.888287e-01	0.410	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.889193e-01	0.410	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.889193e-01	0.410	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.889193e-01	0.410	0	0
Sensory processing of sound	R-HSA-9659379	3.955893e-01	0.403	0	0
Axonal growth stimulation	R-HSA-209563	3.994576e-01	0.399	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.994576e-01	0.399	0	0
MET activates PTPN11	R-HSA-8865999	3.994576e-01	0.399	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	3.994576e-01	0.399	0	0
STAT6-mediated induction of chemokines	R-HSA-3249367	3.994576e-01	0.399	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.994576e-01	0.399	0	0
CASP5-mediated substrate cleavage	R-HSA-9960525	3.994576e-01	0.399	0	0
CASP4-mediated substrate cleavage	R-HSA-9960519	3.994576e-01	0.399	0	0
Cellular response to chemical stress	R-HSA-9711123	4.053545e-01	0.392	0	0
Aquaporin-mediated transport	R-HSA-445717	4.066363e-01	0.391	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	4.115315e-01	0.386	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.115315e-01	0.386	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	4.115315e-01	0.386	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	4.115315e-01	0.386	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	4.115315e-01	0.386	0	0
Suppression of phagosomal maturation	R-HSA-9637687	4.115315e-01	0.386	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	4.159961e-01	0.381	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.159961e-01	0.381	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	4.159961e-01	0.381	0	0
Mismatch Repair	R-HSA-5358508	4.159961e-01	0.381	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	4.159961e-01	0.381	0	0
Platelet sensitization by LDL	R-HSA-432142	4.159961e-01	0.381	0	0
Formation of the posterior neural plate	R-HSA-9832991	4.177077e-01	0.379	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	4.177077e-01	0.379	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	4.192119e-01	0.378	0	0
Signalling to ERKs	R-HSA-187687	4.262836e-01	0.370	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.262836e-01	0.370	0	0
PERK regulates gene expression	R-HSA-381042	4.262836e-01	0.370	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	4.263369e-01	0.370	0	0
Downstream TCR signaling	R-HSA-202424	4.288663e-01	0.368	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.294788e-01	0.367	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.340500e-01	0.362	0	0
Signaling by FGFR	R-HSA-190236	4.344543e-01	0.362	0	0
Regulation of insulin secretion	R-HSA-422356	4.344543e-01	0.362	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.426714e-01	0.354	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.426714e-01	0.354	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	4.426714e-01	0.354	0	0
The NLRP3 inflammasome	R-HSA-844456	4.426714e-01	0.354	0	0
Maturation of nucleoprotein	R-HSA-9694631	4.426714e-01	0.354	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	4.520904e-01	0.345	0	0
PI3K events in ERBB4 signaling	R-HSA-1250342	4.520904e-01	0.345	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.520904e-01	0.345	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.520904e-01	0.345	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	4.520904e-01	0.345	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	4.547320e-01	0.342	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.547320e-01	0.342	0	0
HCN channels	R-HSA-1296061	4.576943e-01	0.339	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.576943e-01	0.339	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.576943e-01	0.339	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.576943e-01	0.339	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.576943e-01	0.339	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.576943e-01	0.339	0	0
Signaling by MAP2K mutants	R-HSA-9652169	4.576943e-01	0.339	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.576943e-01	0.339	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	4.576943e-01	0.339	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	4.576943e-01	0.339	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.576943e-01	0.339	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.576943e-01	0.339	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.576943e-01	0.339	0	0
NADE modulates death signalling	R-HSA-205025	4.576943e-01	0.339	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	4.576943e-01	0.339	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.576943e-01	0.339	0	0
Dopamine receptors	R-HSA-390651	4.576943e-01	0.339	0	0
Toxicity of tetanus toxin (tetX)	R-HSA-5250982	4.576943e-01	0.339	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.578962e-01	0.339	0	0
Rab regulation of trafficking	R-HSA-9007101	4.663971e-01	0.331	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	4.671303e-01	0.331	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	4.688560e-01	0.329	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	4.688560e-01	0.329	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	4.723070e-01	0.326	0	0
Diseases of DNA repair	R-HSA-9675135	4.723070e-01	0.326	0	0
Protein-protein interactions at synapses	R-HSA-6794362	4.761550e-01	0.322	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	4.782914e-01	0.320	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	4.847786e-01	0.314	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	4.847786e-01	0.314	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	4.852834e-01	0.314	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.852834e-01	0.314	0	0
Polymerase switching	R-HSA-69091	4.852834e-01	0.314	0	0
Leading Strand Synthesis	R-HSA-69109	4.852834e-01	0.314	0	0
Scavenging by Class F Receptors	R-HSA-3000484	4.852834e-01	0.314	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.852834e-01	0.314	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	4.887311e-01	0.311	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	4.891758e-01	0.311	0	0
Lagging Strand Synthesis	R-HSA-69186	4.944729e-01	0.306	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	4.944729e-01	0.306	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	4.944729e-01	0.306	0	0
Basigin interactions	R-HSA-210991	4.944729e-01	0.306	0	0
Inositol phosphate metabolism	R-HSA-1483249	4.975682e-01	0.303	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	5.038262e-01	0.298	0	0
Signaling by ALK	R-HSA-201556	5.038262e-01	0.298	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.102867e-01	0.292	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	5.102867e-01	0.292	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.102867e-01	0.292	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.102867e-01	0.292	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.102867e-01	0.292	0	0
Defective F9 activation	R-HSA-9673221	5.102867e-01	0.292	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.102867e-01	0.292	0	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.102867e-01	0.292	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.102867e-01	0.292	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.102867e-01	0.292	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.102867e-01	0.292	0	0
Reelin signalling pathway	R-HSA-8866376	5.102867e-01	0.292	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	5.102867e-01	0.292	0	0
Nectin/Necl trans heterodimerization	R-HSA-420597	5.102867e-01	0.292	0	0
Interleukin-36 pathway	R-HSA-9014826	5.102867e-01	0.292	0	0
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	5.102867e-01	0.292	0	0
Assembly of Viral Components at the Budding Site	R-HSA-168316	5.102867e-01	0.292	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	5.125895e-01	0.290	0	0
ABC transporter disorders	R-HSA-5619084	5.138633e-01	0.289	0	0
Pyruvate metabolism	R-HSA-70268	5.157084e-01	0.288	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.171944e-01	0.286	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.171944e-01	0.286	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	5.171944e-01	0.286	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.171944e-01	0.286	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	5.194574e-01	0.284	0	0
Regulation of beta-cell development	R-HSA-186712	5.252167e-01	0.280	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	5.419048e-01	0.266	0	0
G0 and Early G1	R-HSA-1538133	5.419048e-01	0.266	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.437556e-01	0.265	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	5.437556e-01	0.265	0	0
Circadian clock	R-HSA-9909396	5.441877e-01	0.264	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.477597e-01	0.261	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	5.477597e-01	0.261	0	0
Regulation of KIT signaling	R-HSA-1433559	5.477597e-01	0.261	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.577816e-01	0.254	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.577816e-01	0.254	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.577816e-01	0.254	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.577816e-01	0.254	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.577816e-01	0.254	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.577816e-01	0.254	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	5.577816e-01	0.254	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	5.577816e-01	0.254	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	5.577816e-01	0.254	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.577816e-01	0.254	0	0
Generic Transcription Pathway	R-HSA-212436	5.583329e-01	0.253	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.622120e-01	0.250	0	0
Nuclear RNA decay	R-HSA-9930044	5.622120e-01	0.250	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	5.648039e-01	0.248	0	0
Mitochondrial protein import	R-HSA-1268020	5.709748e-01	0.243	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	5.734292e-01	0.242	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.768982e-01	0.239	0	0
Processive synthesis on the lagging strand	R-HSA-69183	5.769404e-01	0.239	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.769404e-01	0.239	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.769404e-01	0.239	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.769404e-01	0.239	0	0
ABC-family proteins mediated transport	R-HSA-382556	5.780652e-01	0.238	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.820172e-01	0.235	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.820172e-01	0.235	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	5.820172e-01	0.235	0	0
Miscellaneous transport and binding events	R-HSA-5223345	5.820172e-01	0.235	0	0
Amino acids regulate mTORC1	R-HSA-9639288	5.893499e-01	0.230	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	5.901270e-01	0.229	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	5.901270e-01	0.229	0	0
Plasma lipoprotein assembly	R-HSA-8963898	5.901270e-01	0.229	0	0
TBC/RABGAPs	R-HSA-8854214	5.942588e-01	0.226	0	0
Signaling by FGFR in disease	R-HSA-1226099	5.967137e-01	0.224	0	0
Signaling by LTK in cancer	R-HSA-9842640	6.006726e-01	0.221	0	0
Erythropoietin activates STAT5	R-HSA-9027283	6.006726e-01	0.221	0	0
Autointegration results in viral DNA circles	R-HSA-177539	6.006726e-01	0.221	0	0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	6.006726e-01	0.221	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	6.006726e-01	0.221	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.006726e-01	0.221	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	6.006726e-01	0.221	0	0
CREB phosphorylation	R-HSA-199920	6.006726e-01	0.221	0	0
Neurofascin interactions	R-HSA-447043	6.006726e-01	0.221	0	0
eNOS activation	R-HSA-203615	6.012955e-01	0.221	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	6.012955e-01	0.221	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	6.047174e-01	0.218	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.047174e-01	0.218	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.047174e-01	0.218	0	0
Iron uptake and transport	R-HSA-917937	6.101426e-01	0.215	0	0
Proteasome assembly	R-HSA-9907900	6.112155e-01	0.214	0	0
G1 Phase	R-HSA-69236	6.112155e-01	0.214	0	0
Cyclin D associated events in G1	R-HSA-69231	6.112155e-01	0.214	0	0
Tight junction interactions	R-HSA-420029	6.121398e-01	0.213	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	6.121398e-01	0.213	0	0
Hyaluronan degradation	R-HSA-2160916	6.121398e-01	0.213	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	6.157058e-01	0.211	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	6.191436e-01	0.208	0	0
Disorders of transmembrane transporters	R-HSA-5619115	6.199729e-01	0.208	0	0
Fanconi Anemia Pathway	R-HSA-6783310	6.277525e-01	0.202	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.310885e-01	0.200	0	0
Coenzyme A biosynthesis	R-HSA-196783	6.310885e-01	0.200	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	6.333436e-01	0.198	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	6.362863e-01	0.196	0	0
Translation of Structural Proteins	R-HSA-9694635	6.362863e-01	0.196	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	6.381942e-01	0.195	0	0
RNA Polymerase III Transcription	R-HSA-74158	6.381942e-01	0.195	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	6.394060e-01	0.194	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.394060e-01	0.194	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	6.394060e-01	0.194	0	0
Netrin mediated repulsion signals	R-HSA-418886	6.394060e-01	0.194	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.394060e-01	0.194	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	6.394060e-01	0.194	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.394060e-01	0.194	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.394060e-01	0.194	0	0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	6.394060e-01	0.194	0	0
Disinhibition of SNARE formation	R-HSA-114516	6.394060e-01	0.194	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.394060e-01	0.194	0	0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	6.394060e-01	0.194	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	6.394060e-01	0.194	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.394060e-01	0.194	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.394060e-01	0.194	0	0
VLDL clearance	R-HSA-8964046	6.394060e-01	0.194	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	6.394060e-01	0.194	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	6.394060e-01	0.194	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	6.438569e-01	0.191	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	6.537268e-01	0.185	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	6.537268e-01	0.185	0	0
Insulin processing	R-HSA-264876	6.537268e-01	0.185	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	6.537268e-01	0.185	0	0
Maturation of hRSV A proteins	R-HSA-9828806	6.537268e-01	0.185	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	6.557858e-01	0.183	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	6.639676e-01	0.178	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	6.727927e-01	0.172	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	6.732839e-01	0.172	0	0
Formation of the Early Elongation Complex	R-HSA-113418	6.732839e-01	0.172	0	0
HIV elongation arrest and recovery	R-HSA-167287	6.732839e-01	0.172	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	6.732839e-01	0.172	0	0
Inflammasomes	R-HSA-622312	6.732839e-01	0.172	0	0
RSK activation	R-HSA-444257	6.743844e-01	0.171	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.743844e-01	0.171	0	0
phospho-PLA2 pathway	R-HSA-111995	6.743844e-01	0.171	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.743844e-01	0.171	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.743844e-01	0.171	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.743844e-01	0.171	0	0
MET receptor recycling	R-HSA-8875656	6.743844e-01	0.171	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.743844e-01	0.171	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.743844e-01	0.171	0	0
TGFBR3 PTM regulation	R-HSA-9839383	6.743844e-01	0.171	0	0
Sodium/Proton exchangers	R-HSA-425986	6.743844e-01	0.171	0	0
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	6.743844e-01	0.171	0	0
Metal ion SLC transporters	R-HSA-425410	6.747270e-01	0.171	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	6.778198e-01	0.169	0	0
Stimuli-sensing channels	R-HSA-2672351	6.778814e-01	0.169	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	6.796695e-01	0.168	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.796695e-01	0.168	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	6.796695e-01	0.168	0	0
Nephron development	R-HSA-9831926	6.796695e-01	0.168	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	6.796695e-01	0.168	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.892092e-01	0.162	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	6.892092e-01	0.162	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	6.892092e-01	0.162	0	0
RAS processing	R-HSA-9648002	6.892092e-01	0.162	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	6.920150e-01	0.160	0	0
Platelet calcium homeostasis	R-HSA-418360	6.920150e-01	0.160	0	0
SLC transporter disorders	R-HSA-5619102	6.986705e-01	0.156	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	7.019329e-01	0.154	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.019329e-01	0.154	0	0
Specification of the neural plate border	R-HSA-9834899	7.019329e-01	0.154	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	7.019329e-01	0.154	0	0
Other interleukin signaling	R-HSA-449836	7.019329e-01	0.154	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	7.041731e-01	0.152	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.050328e-01	0.152	0	0
HIV Transcription Elongation	R-HSA-167169	7.050328e-01	0.152	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	7.050328e-01	0.152	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	7.059716e-01	0.151	0	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	7.059716e-01	0.151	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.059716e-01	0.151	0	0
p75NTR regulates axonogenesis	R-HSA-193697	7.059716e-01	0.151	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.059716e-01	0.151	0	0
Regulation of signaling by NODAL	R-HSA-1433617	7.059716e-01	0.151	0	0
MAPK1 (ERK2) activation	R-HSA-112411	7.059716e-01	0.151	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.059716e-01	0.151	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	7.059716e-01	0.151	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.059716e-01	0.151	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	7.084758e-01	0.150	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.099246e-01	0.149	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	7.099246e-01	0.149	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	7.099246e-01	0.149	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	7.144591e-01	0.146	0	0
The phototransduction cascade	R-HSA-2514856	7.175915e-01	0.144	0	0
Interferon gamma signaling	R-HSA-877300	7.184517e-01	0.144	0	0
Gastrulation	R-HSA-9758941	7.227170e-01	0.141	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.228934e-01	0.141	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	7.228934e-01	0.141	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.228934e-01	0.141	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.228934e-01	0.141	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.228934e-01	0.141	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.228934e-01	0.141	0	0
Co-inhibition by CTLA4	R-HSA-389513	7.228934e-01	0.141	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	7.270214e-01	0.138	0	0
tRNA processing	R-HSA-72306	7.299519e-01	0.137	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.344964e-01	0.134	0	0
Binding and entry of HIV virion	R-HSA-173107	7.344964e-01	0.134	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.344964e-01	0.134	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.344964e-01	0.134	0	0
Interleukin-27 signaling	R-HSA-9020956	7.344964e-01	0.134	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.344964e-01	0.134	0	0
Maturation of spike protein	R-HSA-9683686	7.344964e-01	0.134	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	7.344964e-01	0.134	0	0
Sperm Motility And Taxes	R-HSA-1300642	7.344964e-01	0.134	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	7.344964e-01	0.134	0	0
Tandem pore domain potassium channels	R-HSA-1296346	7.344964e-01	0.134	0	0
Innate Immune System	R-HSA-168249	7.356487e-01	0.133	1	0
G-protein activation	R-HSA-202040	7.425940e-01	0.129	0	0
ERK/MAPK targets	R-HSA-198753	7.425940e-01	0.129	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	7.425940e-01	0.129	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.433178e-01	0.129	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	7.510388e-01	0.124	0	0
Protein localization	R-HSA-9609507	7.540707e-01	0.123	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	7.588290e-01	0.120	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	7.588290e-01	0.120	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.602554e-01	0.119	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.602554e-01	0.119	0	0
LGI-ADAM interactions	R-HSA-5682910	7.602554e-01	0.119	0	0
vRNA Synthesis	R-HSA-192814	7.602554e-01	0.119	0	0
vRNP Assembly	R-HSA-192905	7.602554e-01	0.119	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.602554e-01	0.119	0	0
Suppression of apoptosis	R-HSA-9635465	7.602554e-01	0.119	0	0
PECAM1 interactions	R-HSA-210990	7.602554e-01	0.119	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.602554e-01	0.119	0	0
Interleukin-2 signaling	R-HSA-9020558	7.602554e-01	0.119	0	0
Dissolution of Fibrin Clot	R-HSA-75205	7.602554e-01	0.119	0	0
Attachment and Entry	R-HSA-9694614	7.610821e-01	0.119	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	7.610821e-01	0.119	0	0
Ribavirin ADME	R-HSA-9755088	7.610821e-01	0.119	0	0
Resolution of D-Loop Structures	R-HSA-5693537	7.735728e-01	0.111	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.735728e-01	0.111	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	7.735728e-01	0.111	0	0
Amine ligand-binding receptors	R-HSA-375280	7.753439e-01	0.111	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	7.784072e-01	0.109	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.784072e-01	0.109	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	7.784072e-01	0.109	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	7.784072e-01	0.109	0	0
LDL clearance	R-HSA-8964038	7.784072e-01	0.109	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	7.784072e-01	0.109	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.793840e-01	0.108	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.835166e-01	0.106	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.835166e-01	0.106	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	7.835166e-01	0.106	0	0
Proton-coupled monocarboxylate transport	R-HSA-433692	7.835166e-01	0.106	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	7.835166e-01	0.106	0	0
ERKs are inactivated	R-HSA-202670	7.835166e-01	0.106	0	0
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.835166e-01	0.106	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.835166e-01	0.106	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	7.875693e-01	0.104	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.875693e-01	0.104	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.875693e-01	0.104	0	0
Hyaluronan metabolism	R-HSA-2142845	7.875693e-01	0.104	0	0
Somitogenesis	R-HSA-9824272	7.876910e-01	0.104	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.946211e-01	0.100	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.946211e-01	0.100	1	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	7.946211e-01	0.100	0	0
Growth hormone receptor signaling	R-HSA-982772	7.946211e-01	0.100	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.994896e-01	0.097	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.994896e-01	0.097	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	8.008399e-01	0.096	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	8.045222e-01	0.094	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	8.045222e-01	0.094	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	8.045222e-01	0.094	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.045222e-01	0.094	0	0
GRB2 events in EGFR signaling	R-HSA-179812	8.045222e-01	0.094	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	8.045222e-01	0.094	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.045222e-01	0.094	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	8.045222e-01	0.094	0	0
Interleukin-35 Signalling	R-HSA-8984722	8.045222e-01	0.094	0	0
Signaling by LTK	R-HSA-9842663	8.045222e-01	0.094	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.045222e-01	0.094	0	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.045222e-01	0.094	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.045222e-01	0.094	0	0
OAS antiviral response	R-HSA-8983711	8.045222e-01	0.094	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.097762e-01	0.092	0	0
Mitochondrial RNA degradation	R-HSA-9836573	8.097762e-01	0.092	0	0
Peroxisomal protein import	R-HSA-9033241	8.116910e-01	0.091	0	0
GPVI-mediated activation cascade	R-HSA-114604	8.134076e-01	0.090	0	0
G1/S-Specific Transcription	R-HSA-69205	8.134076e-01	0.090	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.145939e-01	0.089	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	8.234907e-01	0.084	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	8.234907e-01	0.084	0	0
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	8.234907e-01	0.084	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	8.234907e-01	0.084	0	0
Processing of SMDT1	R-HSA-8949664	8.234907e-01	0.084	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.234907e-01	0.084	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.234907e-01	0.084	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.234907e-01	0.084	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	8.239252e-01	0.084	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	8.239252e-01	0.084	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.239252e-01	0.084	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.239252e-01	0.084	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.239252e-01	0.084	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	8.308373e-01	0.080	0	0
Formation of paraxial mesoderm	R-HSA-9793380	8.308373e-01	0.080	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.365310e-01	0.078	0	0
MET activates PTK2 signaling	R-HSA-8874081	8.371207e-01	0.077	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.371207e-01	0.077	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.371207e-01	0.077	0	0
Urea cycle	R-HSA-70635	8.371207e-01	0.077	0	0
Removal of the Flap Intermediate	R-HSA-69166	8.406195e-01	0.075	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	8.406195e-01	0.075	0	0
Hydrolysis of LPC	R-HSA-1483115	8.406195e-01	0.075	0	0
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	8.406195e-01	0.075	0	0
Formation of the active cofactor, UDP-glucuronate	R-HSA-173599	8.406195e-01	0.075	0	0
Physiological factors	R-HSA-5578768	8.406195e-01	0.075	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.406195e-01	0.075	0	0
Malate-aspartate shuttle	R-HSA-9856872	8.406195e-01	0.075	0	0
Non-canonical inflammasome activation	R-HSA-9686114	8.406195e-01	0.075	0	0
Signal regulatory protein family interactions	R-HSA-391160	8.406195e-01	0.075	0	0
Acyl chain remodeling of CL	R-HSA-1482798	8.406195e-01	0.075	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.406195e-01	0.075	0	0
PI3K Cascade	R-HSA-109704	8.414611e-01	0.075	0	0
Interferon alpha/beta signaling	R-HSA-909733	8.451684e-01	0.073	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.471366e-01	0.072	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.494145e-01	0.071	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	8.494145e-01	0.071	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	8.494145e-01	0.071	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.494145e-01	0.071	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	8.496326e-01	0.071	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.560585e-01	0.067	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.560871e-01	0.067	0	0
Erythropoietin activates RAS	R-HSA-9027284	8.560871e-01	0.067	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.560871e-01	0.067	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	8.560871e-01	0.067	0	0
p38MAPK events	R-HSA-171007	8.560871e-01	0.067	0	0
Other semaphorin interactions	R-HSA-416700	8.560871e-01	0.067	0	0
DNA Damage Reversal	R-HSA-73942	8.560871e-01	0.067	0	0
IGF1R signaling cascade	R-HSA-2428924	8.565518e-01	0.067	0	0
Neurexins and neuroligins	R-HSA-6794361	8.595178e-01	0.066	0	0
Insulin receptor recycling	R-HSA-77387	8.608572e-01	0.065	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.608572e-01	0.065	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.608572e-01	0.065	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	8.643642e-01	0.063	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.665629e-01	0.062	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.700544e-01	0.060	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	8.700544e-01	0.060	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.700544e-01	0.060	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.700544e-01	0.060	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	8.700544e-01	0.060	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	8.700544e-01	0.060	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.700544e-01	0.060	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	8.700544e-01	0.060	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.700544e-01	0.060	0	0
Activation of SMO	R-HSA-5635838	8.700544e-01	0.060	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	8.700544e-01	0.060	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.700544e-01	0.060	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.700544e-01	0.060	0	0
Killing mechanisms	R-HSA-9664420	8.700544e-01	0.060	0	0
Attachment and Entry	R-HSA-9678110	8.700544e-01	0.060	0	0
Virus Assembly and Release	R-HSA-168268	8.700544e-01	0.060	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	8.702417e-01	0.060	0	0
FOXO-mediated transcription	R-HSA-9614085	8.711101e-01	0.060	0	0
Signaling by Erythropoietin	R-HSA-9006335	8.714981e-01	0.060	0	0
mRNA Capping	R-HSA-72086	8.714981e-01	0.060	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	8.714981e-01	0.060	0	0
Glucagon-type ligand receptors	R-HSA-420092	8.714981e-01	0.060	0	0
Potential therapeutics for SARS	R-HSA-9679191	8.727333e-01	0.059	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.754346e-01	0.058	0	0
Intra-Golgi traffic	R-HSA-6811438	8.754346e-01	0.058	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.754346e-01	0.058	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.796238e-01	0.056	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.813852e-01	0.055	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	8.813852e-01	0.055	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.813852e-01	0.055	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.813852e-01	0.055	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.813852e-01	0.055	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	8.826668e-01	0.054	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	8.826668e-01	0.054	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	8.826668e-01	0.054	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	8.826668e-01	0.054	0	0
Phase 2 - plateau phase	R-HSA-5576893	8.826668e-01	0.054	0	0
Fibronectin matrix formation	R-HSA-1566977	8.826668e-01	0.054	0	0
Passive transport by Aquaporins	R-HSA-432047	8.826668e-01	0.054	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	8.826668e-01	0.054	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	8.826668e-01	0.054	0	0
G alpha (z) signalling events	R-HSA-418597	8.832944e-01	0.054	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	8.837790e-01	0.054	0	0
Cargo concentration in the ER	R-HSA-5694530	8.905644e-01	0.050	0	0
Molecules associated with elastic fibres	R-HSA-2129379	8.905644e-01	0.050	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.940558e-01	0.049	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.940558e-01	0.049	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	8.940558e-01	0.049	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.940558e-01	0.049	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	8.940558e-01	0.049	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	8.940558e-01	0.049	0	0
Catecholamine biosynthesis	R-HSA-209905	8.940558e-01	0.049	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.940558e-01	0.049	0	0
Choline catabolism	R-HSA-6798163	8.940558e-01	0.049	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	8.940558e-01	0.049	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.940558e-01	0.049	0	0
Formation of the cornified envelope	R-HSA-6809371	8.949551e-01	0.048	0	0
IRS-mediated signalling	R-HSA-112399	8.971279e-01	0.047	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	8.978889e-01	0.047	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	9.043399e-01	0.044	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	9.043399e-01	0.044	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.043454e-01	0.044	0	0
Extension of Telomeres	R-HSA-180786	9.094968e-01	0.041	0	0
Platelet homeostasis	R-HSA-418346	9.126922e-01	0.040	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.136262e-01	0.039	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	9.136262e-01	0.039	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	9.136262e-01	0.039	0	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.136262e-01	0.039	0	0
Diseases of hemostasis	R-HSA-9671793	9.136262e-01	0.039	0	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.136262e-01	0.039	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.136262e-01	0.039	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.148275e-01	0.039	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.151709e-01	0.038	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.183367e-01	0.037	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.198028e-01	0.036	0	0
Signal amplification	R-HSA-392518	9.210581e-01	0.036	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.210581e-01	0.036	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.220116e-01	0.035	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.220116e-01	0.035	0	0
Signaling by NODAL	R-HSA-1181150	9.220116e-01	0.035	0	0
Acyl chain remodelling of PI	R-HSA-1482922	9.220116e-01	0.035	0	0
Creatine metabolism	R-HSA-71288	9.220116e-01	0.035	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.220116e-01	0.035	0	0
Heme signaling	R-HSA-9707616	9.255744e-01	0.034	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.255744e-01	0.034	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.259082e-01	0.033	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.273225e-01	0.033	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.273225e-01	0.033	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.273225e-01	0.033	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.295834e-01	0.032	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.295834e-01	0.032	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.295834e-01	0.032	0	0
Signalling to RAS	R-HSA-167044	9.295834e-01	0.032	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.295834e-01	0.032	0	0
Abacavir metabolism	R-HSA-2161541	9.295834e-01	0.032	0	0
Acyl chain remodelling of PG	R-HSA-1482925	9.295834e-01	0.032	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.331152e-01	0.030	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	9.344236e-01	0.029	0	0
Azathioprine ADME	R-HSA-9748787	9.344236e-01	0.029	0	0
Insulin receptor signalling cascade	R-HSA-74751	9.348146e-01	0.029	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.364204e-01	0.029	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	9.364204e-01	0.029	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.364204e-01	0.029	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	9.364204e-01	0.029	0	0
Serine metabolism	R-HSA-977347	9.364204e-01	0.029	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.364204e-01	0.029	0	0
Integrin cell surface interactions	R-HSA-216083	9.372240e-01	0.028	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.384686e-01	0.028	0	0
NCAM1 interactions	R-HSA-419037	9.384686e-01	0.028	0	0
Metabolism of folate and pterines	R-HSA-196757	9.384686e-01	0.028	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.410115e-01	0.026	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.411602e-01	0.026	1	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.425939e-01	0.026	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.425939e-01	0.026	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.425939e-01	0.026	0	0
Cellular hexose transport	R-HSA-189200	9.425939e-01	0.026	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.430018e-01	0.025	0	0
Elastic fibre formation	R-HSA-1566948	9.434135e-01	0.025	0	0
Kidney development	R-HSA-9830369	9.467332e-01	0.024	0	0
Signaling by Insulin receptor	R-HSA-74752	9.471651e-01	0.024	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.474680e-01	0.023	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.479786e-01	0.023	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.481684e-01	0.023	0	0
Interleukin receptor SHC signaling	R-HSA-912526	9.481684e-01	0.023	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.481684e-01	0.023	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.481684e-01	0.023	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.481684e-01	0.023	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.481684e-01	0.023	0	0
Formation of the ureteric bud	R-HSA-9830674	9.481684e-01	0.023	0	0
Mitochondrial mRNA modification	R-HSA-9937008	9.481684e-01	0.023	0	0
Carnitine shuttle	R-HSA-200425	9.481684e-01	0.023	0	0
Transcription of the HIV genome	R-HSA-167172	9.502395e-01	0.022	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.521911e-01	0.021	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.521911e-01	0.021	0	0
Interleukin-2 family signaling	R-HSA-451927	9.521911e-01	0.021	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.532018e-01	0.021	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.532018e-01	0.021	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.532018e-01	0.021	0	0
Complex III assembly	R-HSA-9865881	9.532018e-01	0.021	0	0
Mitochondrial biogenesis	R-HSA-1592230	9.558626e-01	0.020	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.566241e-01	0.019	0	0
G protein gated Potassium channels	R-HSA-1296059	9.577467e-01	0.019	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	9.577467e-01	0.019	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.577467e-01	0.019	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.577467e-01	0.019	0	0
Laminin interactions	R-HSA-3000157	9.577467e-01	0.019	0	0
Acyl chain remodelling of PS	R-HSA-1482801	9.577467e-01	0.019	0	0
Fertilization	R-HSA-1187000	9.577467e-01	0.019	0	0
Formation of the nephric duct	R-HSA-9830364	9.577467e-01	0.019	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.596582e-01	0.018	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	9.618504e-01	0.017	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.618504e-01	0.017	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.618504e-01	0.017	0	0
TRP channels	R-HSA-3295583	9.618504e-01	0.017	0	0
Abacavir ADME	R-HSA-2161522	9.618504e-01	0.017	0	0
Sphingolipid catabolism	R-HSA-9845614	9.618504e-01	0.017	0	0
Adipogenesis	R-HSA-9843745	9.629692e-01	0.016	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.639744e-01	0.016	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.647443e-01	0.016	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.655558e-01	0.015	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.655558e-01	0.015	0	0
Triglyceride biosynthesis	R-HSA-75109	9.655558e-01	0.015	0	0
Signaling by SCF-KIT	R-HSA-1433557	9.659993e-01	0.015	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.689015e-01	0.014	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.689015e-01	0.014	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	9.689015e-01	0.014	0	0
Metabolism of polyamines	R-HSA-351202	9.690946e-01	0.014	0	0
G alpha (s) signalling events	R-HSA-418555	9.716689e-01	0.012	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.719224e-01	0.012	0	0
Neurotransmitter release cycle	R-HSA-112310	9.728263e-01	0.012	0	0
DAP12 signaling	R-HSA-2424491	9.746500e-01	0.011	0	0
Neurotransmitter clearance	R-HSA-112311	9.746500e-01	0.011	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.755021e-01	0.011	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.770168e-01	0.010	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	9.793365e-01	0.009	0	0
HS-GAG degradation	R-HSA-2024096	9.793365e-01	0.009	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.797738e-01	0.009	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.831570e-01	0.007	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	9.831570e-01	0.007	0	0
Heme degradation	R-HSA-189483	9.831570e-01	0.007	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.839154e-01	0.007	0	0
Potassium Channels	R-HSA-1296071	9.842055e-01	0.007	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.843836e-01	0.007	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.847937e-01	0.007	0	0
Neddylation	R-HSA-8951664	9.853838e-01	0.006	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.858985e-01	0.006	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.862714e-01	0.006	0	0
HS-GAG biosynthesis	R-HSA-2022928	9.876056e-01	0.005	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.876056e-01	0.005	0	0
RUNX2 regulates bone development	R-HSA-8941326	9.876056e-01	0.005	0	0
Lysine catabolism	R-HSA-71064	9.888103e-01	0.005	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.890802e-01	0.005	0	0
tRNA processing in the mitochondrion	R-HSA-6785470	9.898979e-01	0.004	0	0
Dectin-2 family	R-HSA-5621480	9.900086e-01	0.004	0	0
Synthesis of PA	R-HSA-1483166	9.900086e-01	0.004	0	0
Parasite infection	R-HSA-9664407	9.903148e-01	0.004	0	0
Leishmania phagocytosis	R-HSA-9664417	9.903148e-01	0.004	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.903148e-01	0.004	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.905694e-01	0.004	0	0
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.908798e-01	0.004	0	0
Pentose phosphate pathway	R-HSA-71336	9.908798e-01	0.004	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.909885e-01	0.004	0	0
Leishmania infection	R-HSA-9658195	9.909885e-01	0.004	0	0
Extracellular matrix organization	R-HSA-1474244	9.913399e-01	0.004	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.916401e-01	0.004	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.916401e-01	0.004	0	0
Peptide hormone metabolism	R-HSA-2980736	9.917007e-01	0.004	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.917664e-01	0.004	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.917664e-01	0.004	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.917664e-01	0.004	0	0
tRNA Aminoacylation	R-HSA-379724	9.923550e-01	0.003	0	0
Maturation of spike protein	R-HSA-9694548	9.925668e-01	0.003	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.932895e-01	0.003	0	0
Collagen formation	R-HSA-1474290	9.935092e-01	0.003	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.936100e-01	0.003	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.939419e-01	0.003	0	0
Activation of GABAB receptors	R-HSA-991365	9.939419e-01	0.003	0	0
GABA B receptor activation	R-HSA-977444	9.939419e-01	0.003	0	0
Complex I biogenesis	R-HSA-6799198	9.941594e-01	0.003	0	0
DAP12 interactions	R-HSA-2172127	9.950627e-01	0.002	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.955429e-01	0.002	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.955845e-01	0.002	0	0
Metabolism of proteins	R-HSA-392499	9.955906e-01	0.002	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.958356e-01	0.002	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.959299e-01	0.002	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.962827e-01	0.002	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.967209e-01	0.001	0	0
Post-translational protein modification	R-HSA-597592	9.967266e-01	0.001	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.971703e-01	0.001	0	0
ECM proteoglycans	R-HSA-3000178	9.971703e-01	0.001	0	0
Retinoid metabolism and transport	R-HSA-975634	9.971703e-01	0.001	0	0
Metabolism of cofactors	R-HSA-8978934	9.971703e-01	0.001	0	0
Visual phototransduction	R-HSA-2187338	9.977654e-01	0.001	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.978224e-01	0.001	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.980369e-01	0.001	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	9.980594e-01	0.001	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.982105e-01	0.001	0	0
Glucuronidation	R-HSA-156588	9.982255e-01	0.001	0	0
G alpha (q) signalling events	R-HSA-416476	9.984816e-01	0.001	0	0
Antimicrobial peptides	R-HSA-6803157	9.985382e-01	0.001	0	0
Digestion	R-HSA-8935690	9.985541e-01	0.001	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.986510e-01	0.001	1	1
PPARA activates gene expression	R-HSA-1989781	9.987208e-01	0.001	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.988697e-01	0.000	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.988697e-01	0.000	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.988893e-01	0.000	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.989365e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.989409e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.990181e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.990181e-01	0.000	0	0
GABA receptor activation	R-HSA-977443	9.990400e-01	0.000	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.990606e-01	0.000	0	0
PI Metabolism	R-HSA-1483255	9.992402e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.992644e-01	0.000	0	0
Digestion and absorption	R-HSA-8963743	9.992939e-01	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.994247e-01	0.000	0	0
Nicotinate metabolism	R-HSA-196807	9.995313e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.995534e-01	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.995769e-01	0.000	0	0
Glycosphingolipid catabolism	R-HSA-9840310	9.996553e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.996889e-01	0.000	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.997192e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.997192e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.997202e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.997465e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.998027e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.998123e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.998125e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.998482e-01	0.000	0	0
Cholesterol biosynthesis	R-HSA-191273	9.998482e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999179e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.999440e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999658e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999735e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.999805e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999824e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999857e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999867e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999901e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999916e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.999925e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999926e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999930e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.999965e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999978e-01	0.000	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999982e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999984e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999991e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999992e-01	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	9.999992e-01	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999993e-01	0.000	0	0
Drug ADME	R-HSA-9748784	9.999996e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999996e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999996e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999997e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999999e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999999e-01	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	9.999999e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0