CAMK1A

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O00429 S637 SIGNOR DNM1L DLP1 DRP1 PQKGHAVNLLDVPVPVARKLsAREQRDCEVIERLIKSYFLI
O14639 S452 Sugiyama ABLIM1 ABLIM KIAA0059 LIMAB1 PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O43432 S1156 SIGNOR|iPTMNet|PSP EIF4G3 KNDKPLPSATARPNTFMRGGssKDLLDNQsQEEQRREMLET
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S15 Sugiyama HSPB1 HSP27 HSP28 ______MTERRVPFsLLRGPsWDPFRDWyPHsRLFDQAFGL
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05783 S53 SIGNOR|ELM KRT18 CYK18 PIG46 AsVyAGAGGsGsRIsVsRstsFRGGMGsGGLAtGIAGGLAG
P06733 Y189 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 MILPVGAANFREAMRIGAEVyHNLKNVIKEKyGKDAtNVGD
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07900 Y160 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA SAYLVAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPM
P08238 Y155 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB SAYLVAEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPI
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08708 S89 Sugiyama RPS17 RPS17L ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P08708 Y84 Sugiyama RPS17 RPS17L GPVRGISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKE
P09104 Y44 Sugiyama ENO2 LyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKGVLK
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P13929 Y44 Sugiyama ENO3 LHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKGVLK
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17600 S9 SIGNOR|iPTMNet SYN1 ____________MNYLRRRLsDSNFMANLPNGYMTDLQRPQ
P18206 S1002 Sugiyama VCL SKGNDIIAAAKRMALLMAEMsRLVRGGSGTKRALIQCAKDI
P18846 S63 SIGNOR|iPTMNet ATF1 DsSDsIGssQKAHGILARRPsYRKILKDLsSEDTRGRKGDG
P19474 S3 Sugiyama TRIM21 RNF81 RO52 SSA1 __________________MAsAARLTMMWEEVTCPICLDPF
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23588 Y609 Sugiyama EIF4B sASKyAALsVDGEDENEGEDyAE__________________
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P24844 S20 PSP MYL9 MLC2 MRLC1 MYRL2 _MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P29475 S746 iPTMNet NOS1 GTPTKRRAIGFKKLAEAVKFsAKLMGQAMAKRVKATILYAT
P29475 S852 SIGNOR|iPTMNet NOS1 EMRHPNSVQEERKSYKVRFNsVSSYSDsQKSSGDGPDLRDN
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P35968 Y951 Sugiyama KDR FLK1 VEGFR2 KRNEFVPYKTKGARFRQGKDyVGAIPVDLKRRLDSITSSQS
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39019 S59 PSP RPS19 LAKHKELAPyDENWFytRAAstARHLYLRGGAGVGsMTKIY
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 T1764 Sugiyama MKI67 LVDtPtssKPQPKRSLRKADtEEEFLAFRKQTPSAGKAMHt
P46527 T157 SIGNOR|PSP CDKN1B KIP1 p27 PsDsQTGLAEQCAGIRKRPAtDDSSTQNKRANRTEENVsDG
P46527 T198 SIGNOR|PSP CDKN1B KIP1 p27 sPNAGSVEQtPKKPGLRRRQt____________________
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49757 S276 SIGNOR NUMB C14orf41 NNPHAIPRRHAPIEQLARQGsFRGFPALsQKMSPFKRQLsL
P52943 S115 Sugiyama CRIP2 CRP2 AARAEERKAsGPPKGPsRAssVttFtGEPNtCPRCSKKVYF
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P60709 T303 Sugiyama ACTB MKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPs
P60709 Y306 Sugiyama ACTB DVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPstMK
P61604 Y88 Sugiyama HSPE1 GDKVLLPEyGGtKVVLDDKDyFLFRDGDILGKyVD______
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P63220 S65 Sugiyama RPS21 RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63220 Y53 Sugiyama RPS21 QMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRLA
P63261 T303 Sugiyama ACTG1 ACTG MKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPs
P63261 Y306 Sugiyama ACTG1 ACTG DVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPstMK
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
Q00587 S192 Sugiyama CDC42EP1 BORG5 CEP1 MSE55 PHDRDRDGsFPsEPGLRRsDsLLsFRLDLDLGPSLLSELLG
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105 S133 Sugiyama SET DEEALHYLTRVEVtEFEDIKsGyRIDFyFDENPyFENKVLS
Q01105 Y140 Sugiyama SET LTRVEVtEFEDIKsGyRIDFyFDENPyFENKVLSKEFHLNE
Q01105 Y146 Sugiyama SET tEFEDIKsGyRIDFyFDENPyFENKVLSKEFHLNEsGDPss
Q05209 S435 Sugiyama PTPN12 LPGKNESTIEQIDKKLERNLsFEIKKVPLQEGPKsFDGNtL
Q05469 S855 PSP LIPE SGRKSQKMSEPIAEPMRRsVsEAALAQPQGPLGTDSLKNLT
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q09472 S89 ELM EP300 P300 GMVQDAASKHKQLSELLRsGssPNLNMGVGGPGQVMAsQAQ
Q13085 S25 ELM ACACA ACAC ACC1 ACCA sPLAQPLELNQHSRFIIGsVsEDNsEDEISNLVKLDLLEEK
Q14012 S324 Sugiyama CAMK1 KQAFNAtAVVRHMRKLQLGtsQEGQGQtAsHGELLtPVAGG
Q14012 S333 Sugiyama CAMK1 VRHMRKLQLGtsQEGQGQtAsHGELLtPVAGGPAAGCCCRD
Q14012 S363 Sugiyama CAMK1 GGPAAGCCCRDCCVEPGtELsPtLPHQL_____________
Q14012 T177 SIGNOR|ELM|iPTMNet CAMK1 KIMISDFGLSKMEDPGSVLstACGTPGYVAPEVLAQKPYSK
Q14012 T310 Sugiyama CAMK1 VSEQIKKNFAKSKWKQAFNAtAVVRHMRKLQLGtsQEGQGQ
Q14012 T323 Sugiyama CAMK1 WKQAFNAtAVVRHMRKLQLGtsQEGQGQtAsHGELLtPVAG
Q14012 T331 Sugiyama CAMK1 AVVRHMRKLQLGtsQEGQGQtAsHGELLtPVAGGPAAGCCC
Q14012 T339 Sugiyama CAMK1 LQLGtsQEGQGQtAsHGELLtPVAGGPAAGCCCRDCCVEPG
Q14012 T365 Sugiyama CAMK1 PAAGCCCRDCCVEPGtELsPtLPHQL_______________
Q14568 Y160 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 SAYLVAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERM
Q16566 T200 ELM CAMK4 CAMK CAMK-GR CAMKIV PLKIADFGLsKIVEHQVLMKtVCGTPGYCAPEILRGCAYGP
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q5UIP0 S1688 Sugiyama RIF1 PVPESNLRTRNAIKRLHKRDsFDNCsLGESSKIGIsDIssL
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q86V81 Y250 Sugiyama ALYREF ALY BEF THOC4 AGRNSKQQLsAEELDAQLDAyNARMDts_____________
Q8IU85 T313 Sugiyama CAMK1D CAMKID VSAQIRKNFAKSKWRQAFNAtAVVRHMRKLHLGssLDssNA
Q8NFH8 S631 Sugiyama REPS2 POB1 AIQTAIRKNKEANAVLARLNsELQQQLKEVHQERIALENQL
Q8WVC0 T477 Sugiyama LEO1 RDL FDVYKAPLQGDHNHLFIRQGtGLQGQAVFKTKLTFRPHstD
Q96D71 S767 Sugiyama REPS1 AIQAsIRRNKETNTVLARLNsELQQQLKDVLEERISLEVQL
Q99618 S94 Sugiyama CDCA3 C8 GRCC8 TOME1 ARtPMKTSsGDPPsPLVKQLsEVFETEDSKSNLPPEPVLPP
Q9BQE3 Y432 Sugiyama TUBA1C TUBA6 GMEEGEFSEAREDMAALEKDyEEVGADsADGEDEGEEy___
Q9BRS2 T509 Sugiyama RIOK1 RIO1 QVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHTTDPDI
Q9NP62 S177 PSP GCM1 GCMA PETKLEAEARRAMKKVNtAPssVSLSLKGSTETRSLPGETQ
Q9NP62 S178 PSP GCM1 GCMA ETKLEAEARRAMKKVNtAPssVSLSLKGSTETRSLPGETQS
Q9NP62 S269 PSP GCM1 GCMA DLTDQTSTVDPMKLYEKRKLsSSRTYsSGDLLPPSASGVYS
Q9NP62 S47 SIGNOR|PSP GCM1 GCMA VKKTDWFQEWPDSYAKHIYSsEDKNAQRHLSSWAMRNTNNH
Q9NP62 T174 PSP GCM1 GCMA HPKPETKLEAEARRAMKKVNtAPssVSLSLKGSTETRSLPG
Q9NY27 S311 Sugiyama PPP4R2 SBBI57 CTRQHCtEEDEEEDEEEEEEsFMtsREMIPERKNQEKESDD
Q9NY27 S315 Sugiyama PPP4R2 SBBI57 HCtEEDEEEDEEEEEEsFMtsREMIPERKNQEKESDDALTV
Q9NY27 T297 Sugiyama PPP4R2 SBBI57 EAssssQDKDKDSRCTRQHCtEEDEEEDEEEEEEsFMtsRE
Q9NY27 T314 Sugiyama PPP4R2 SBBI57 QHCtEEDEEEDEEEEEEsFMtsREMIPERKNQEKESDDALT
Q9UKV0 S220 PSP HDAC9 HDAC7 HDAC7B HDRP KIAA0744 MITR KYTLPGAQDAKDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9UKV0 S451 PSP HDAC9 HDAC7 HDAC7B HDRP KIAA0744 MITR SPGIRGTHKLPRHRPLNRtQsAPLPQSTLAQLVIQQQHQQF
Q9UQL6 S259 SIGNOR|iPTMNet|PSP HDAC5 KIAA0600 KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9UQL6 S498 SIGNOR|iPTMNet|PSP HDAC5 KIAA0600 ATSMRTVGKLPRHRPLSRtQssPLPQSPQALQQLVMQQQHQ
Q9Y570 S15 SIGNOR|PSP PPME1 PME1 PP2593 PRO0750 ______MSALEKSMHLGRLPsRPPLPGsGGsQsGAKMRMGP
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
HSF1-dependent transactivation R-HSA-3371571 3.223118e-10 9.492 0 0
Signal Transduction R-HSA-162582 1.410315e-08 7.851 0 0
Attenuation phase R-HSA-3371568 8.017579e-08 7.096 0 0
Cellular response to heat stress R-HSA-3371556 9.132031e-07 6.039 0 0
NRAGE signals death through JNK R-HSA-193648 8.576396e-07 6.067 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.549650e-06 5.810 0 0
G alpha (12/13) signalling events R-HSA-416482 2.062083e-06 5.686 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.416167e-06 5.355 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.919730e-06 5.308 0 0
HSF1 activation R-HSA-3371511 8.817418e-06 5.055 0 0
Apoptotic execution phase R-HSA-75153 9.835229e-06 5.007 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.130612e-05 4.947 0 0
Death Receptor Signaling R-HSA-73887 1.260549e-05 4.899 0 0
Cell Cycle R-HSA-1640170 1.291030e-05 4.889 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.402063e-05 4.619 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.026941e-05 4.519 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.026941e-05 4.519 0 0
Axon guidance R-HSA-422475 3.331712e-05 4.477 0 0
Mitotic Prometaphase R-HSA-68877 3.578633e-05 4.446 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.662717e-05 4.176 0 0
Cell Cycle, Mitotic R-HSA-69278 1.045533e-04 3.981 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.274023e-04 3.895 0 0
Nervous system development R-HSA-9675108 1.495931e-04 3.825 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.575741e-04 3.803 0 0
Chromatin modifying enzymes R-HSA-3247509 1.587428e-04 3.799 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.719463e-04 3.765 0 0
Activation of RAC1 R-HSA-428540 1.782711e-04 3.749 0 0
Semaphorin interactions R-HSA-373755 2.488518e-04 3.604 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.822199e-04 3.549 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.311922e-04 3.480 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.794152e-04 3.421 0 0
Cell Cycle Checkpoints R-HSA-69620 3.856162e-04 3.414 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.710301e-04 3.173 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.537480e-04 3.185 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.624715e-04 3.179 0 0
Chromatin organization R-HSA-4839726 6.913004e-04 3.160 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.829698e-04 3.106 0 0
Programmed Cell Death R-HSA-5357801 8.128725e-04 3.090 0 0
FLT3 Signaling R-HSA-9607240 8.593153e-04 3.066 0 0
Signaling by Hippo R-HSA-2028269 9.431123e-04 3.025 0 0
Regulation of TP53 Activity R-HSA-5633007 1.096936e-03 2.960 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.200725e-03 2.921 0 0
Signaling by VEGF R-HSA-194138 1.231603e-03 2.910 0 0
M Phase R-HSA-68886 1.298953e-03 2.886 0 0
Apoptosis R-HSA-109581 1.360766e-03 2.866 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.523463e-03 2.817 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.523463e-03 2.817 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.523463e-03 2.817 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.523463e-03 2.817 1 1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.748547e-03 2.757 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.653325e-03 2.782 0 0
Calmodulin induced events R-HSA-111933 1.742721e-03 2.759 0 0
CaM pathway R-HSA-111997 1.742721e-03 2.759 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.777581e-03 2.750 0 0
Signaling by ALK in cancer R-HSA-9700206 1.777581e-03 2.750 0 0
Post NMDA receptor activation events R-HSA-438064 1.894044e-03 2.723 1 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.235955e-03 2.651 0 0
DAG and IP3 signaling R-HSA-1489509 2.486508e-03 2.604 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.529714e-03 2.597 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.801047e-03 2.553 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.895054e-03 2.538 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.144652e-03 2.502 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.539513e-03 2.451 0 0
Neurodegenerative Diseases R-HSA-8863678 3.539513e-03 2.451 0 0
G2/M Transition R-HSA-69275 3.560246e-03 2.449 0 0
Regulation of TP53 Expression R-HSA-6804754 4.001336e-03 2.398 0 0
Signaling by ROBO receptors R-HSA-376176 4.051656e-03 2.392 0 0
Centrosome maturation R-HSA-380287 4.220153e-03 2.375 0 0
Co-stimulation by CD28 R-HSA-389356 4.352703e-03 2.361 0 0
Rab regulation of trafficking R-HSA-9007101 4.214577e-03 2.375 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.560564e-03 2.341 0 0
HDMs demethylate histones R-HSA-3214842 4.560564e-03 2.341 0 0
Long-term potentiation R-HSA-9620244 4.560564e-03 2.341 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.592120e-03 2.338 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.152132e-03 2.288 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.196177e-03 2.284 0 0
The NLRP3 inflammasome R-HSA-844456 5.615593e-03 2.251 0 0
Interleukin-37 signaling R-HSA-9008059 5.690146e-03 2.245 0 0
MAPK family signaling cascades R-HSA-5683057 6.192081e-03 2.208 0 0
Ca-dependent events R-HSA-111996 7.168213e-03 2.145 0 0
Separation of Sister Chromatids R-HSA-2467813 7.238823e-03 2.140 0 0
Ion homeostasis R-HSA-5578775 7.766569e-03 2.110 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.017199e-03 2.096 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.202527e-03 2.086 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 8.758076e-03 2.058 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 8.758076e-03 2.058 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 9.454622e-03 2.024 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 9.454622e-03 2.024 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.669815e-03 2.015 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.493257e-03 2.023 0 0
Netrin-1 signaling R-HSA-373752 1.010669e-02 1.995 0 0
Signaling by Interleukins R-HSA-449147 1.014568e-02 1.994 0 0
Membrane Trafficking R-HSA-199991 1.018047e-02 1.992 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.057727e-02 1.976 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.097622e-02 1.960 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.082106e-02 1.966 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.057727e-02 1.976 0 0
Cellular responses to stimuli R-HSA-8953897 1.083768e-02 1.965 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.105168e-02 1.957 0 0
DARPP-32 events R-HSA-180024 1.119999e-02 1.951 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.148167e-02 1.940 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.178811e-02 1.929 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.187466e-02 1.925 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.215215e-02 1.915 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.215215e-02 1.915 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.296342e-02 1.887 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.585569e-02 1.800 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.585569e-02 1.800 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.585569e-02 1.800 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.501205e-02 1.824 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.480984e-02 1.829 0 0
RAF activation R-HSA-5673000 1.532554e-02 1.815 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.392564e-02 1.856 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.392564e-02 1.856 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.392564e-02 1.856 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.418577e-02 1.848 0 0
Rap1 signalling R-HSA-392517 1.556606e-02 1.808 0 0
TRP channels R-HSA-3295583 1.448388e-02 1.839 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.515872e-02 1.819 1 0
Nef and signal transduction R-HSA-164944 1.501205e-02 1.824 0 0
Signaling by LTK R-HSA-9842663 1.480984e-02 1.829 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.451189e-02 1.838 0 0
Signaling by RAS mutants R-HSA-6802949 1.392564e-02 1.856 0 0
Kinesins R-HSA-983189 1.385983e-02 1.858 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.598390e-02 1.796 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.625571e-02 1.789 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.671351e-02 1.777 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.770594e-02 1.752 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.841157e-02 1.735 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.051709e-02 1.688 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.051709e-02 1.688 0 0
Muscle contraction R-HSA-397014 1.943945e-02 1.711 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.052003e-02 1.688 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.984565e-02 1.702 0 0
RET signaling R-HSA-8853659 2.154745e-02 1.667 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.626379e-02 1.581 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.626379e-02 1.581 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.626379e-02 1.581 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.626379e-02 1.581 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.626379e-02 1.581 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.626379e-02 1.581 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.626379e-02 1.581 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.626379e-02 1.581 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.626379e-02 1.581 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.626379e-02 1.581 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.626379e-02 1.581 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.626379e-02 1.581 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.601812e-02 1.585 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.601812e-02 1.585 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.601812e-02 1.585 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.524768e-02 1.598 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.616685e-02 1.582 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.354160e-02 1.628 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.342254e-02 1.630 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.442444e-02 1.612 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.661629e-02 1.575 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.537538e-02 1.596 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.601812e-02 1.585 0 0
Cellular responses to stress R-HSA-2262752 2.525043e-02 1.598 0 0
Mitotic Anaphase R-HSA-68882 2.527493e-02 1.597 0 0
NrCAM interactions R-HSA-447038 2.601812e-02 1.585 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.300296e-02 1.638 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.693179e-02 1.570 0 0
Cellular Senescence R-HSA-2559583 2.733853e-02 1.563 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.776066e-02 1.557 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.783550e-02 1.555 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.815179e-02 1.550 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.866700e-02 1.543 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.897006e-02 1.538 0 0
PLC beta mediated events R-HSA-112043 2.922496e-02 1.534 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.184662e-02 1.497 0 0
Type I hemidesmosome assembly R-HSA-446107 3.184662e-02 1.497 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.188501e-02 1.496 0 0
PKA activation in glucagon signalling R-HSA-164378 3.188501e-02 1.496 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.262216e-02 1.486 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.188501e-02 1.496 0 0
PKA activation R-HSA-163615 3.188501e-02 1.496 0 0
Neurexins and neuroligins R-HSA-6794361 3.226230e-02 1.491 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.156540e-02 1.501 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.184662e-02 1.497 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.946165e-02 1.531 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.326632e-02 1.478 0 0
p75NTR signals via NF-kB R-HSA-193639 3.326632e-02 1.478 0 0
mRNA Splicing R-HSA-72172 3.355220e-02 1.474 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.359334e-02 1.474 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.359334e-02 1.474 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.416187e-02 1.466 0 0
TCR signaling R-HSA-202403 3.513847e-02 1.454 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.604491e-02 1.443 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.621498e-02 1.441 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 4.042576e-02 1.393 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.934497e-02 1.405 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.934497e-02 1.405 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.934497e-02 1.405 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.934497e-02 1.405 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.934497e-02 1.405 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.934497e-02 1.405 0 0
RNA Polymerase II Transcription R-HSA-73857 3.736300e-02 1.428 0 0
Generic Transcription Pathway R-HSA-212436 4.045635e-02 1.393 0 0
EPH-Ephrin signaling R-HSA-2682334 3.814947e-02 1.419 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.934497e-02 1.405 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.883024e-02 1.411 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.115203e-02 1.386 0 0
PI Metabolism R-HSA-1483255 4.003078e-02 1.398 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 4.181606e-02 1.379 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.217554e-02 1.375 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.343690e-02 1.362 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.343690e-02 1.362 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.343690e-02 1.362 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.354249e-02 1.361 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.354249e-02 1.361 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.578121e-02 1.339 0 0
Inflammasomes R-HSA-622312 4.679580e-02 1.330 0 0
Nephrin family interactions R-HSA-373753 4.769754e-02 1.322 0 0
FOXO-mediated transcription R-HSA-9614085 4.858749e-02 1.313 0 0
Integrin signaling R-HSA-354192 4.899253e-02 1.310 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.899253e-02 1.310 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.096640e-02 1.293 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.135568e-02 1.289 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.160564e-02 1.287 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.176295e-02 1.286 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.515891e-02 1.258 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.515891e-02 1.258 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.288157e-02 1.201 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.288157e-02 1.201 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.334807e-02 1.198 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.651857e-02 1.248 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.044195e-02 1.219 0 0
G-protein mediated events R-HSA-112040 5.625370e-02 1.250 0 0
MTOR signalling R-HSA-165159 5.820910e-02 1.235 0 0
Cell-Cell communication R-HSA-1500931 5.866359e-02 1.232 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.019555e-02 1.220 0 0
NGF-stimulated transcription R-HSA-9031628 6.541645e-02 1.184 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.541645e-02 1.184 0 0
TBC/RABGAPs R-HSA-8854214 6.565239e-02 1.183 0 0
Signaling by SCF-KIT R-HSA-1433557 6.565239e-02 1.183 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.675511e-02 1.176 0 0
Cardiac conduction R-HSA-5576891 6.840027e-02 1.165 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.932580e-02 1.159 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 7.067828e-02 1.151 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 7.067828e-02 1.151 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 7.067828e-02 1.151 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 7.067828e-02 1.151 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.104187e-02 1.148 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 7.104187e-02 1.148 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.118424e-02 1.148 0 0
Breakdown of the nuclear lamina R-HSA-352238 8.217500e-02 1.085 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 8.217500e-02 1.085 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 8.217500e-02 1.085 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 7.566246e-02 1.121 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 7.566246e-02 1.121 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.566246e-02 1.121 0 0
DCC mediated attractive signaling R-HSA-418885 8.349249e-02 1.078 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.349249e-02 1.078 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.349249e-02 1.078 0 0
Polo-like kinase mediated events R-HSA-156711 7.545657e-02 1.122 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 7.545657e-02 1.122 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.969774e-02 1.099 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.210868e-02 1.086 0 0
Trafficking of AMPA receptors R-HSA-399719 7.287840e-02 1.137 0 0
Hedgehog 'off' state R-HSA-5610787 8.032620e-02 1.095 0 0
Signaling by ERBB2 R-HSA-1227986 7.827457e-02 1.106 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.369832e-02 1.133 0 0
Opioid Signalling R-HSA-111885 7.222768e-02 1.141 0 0
Ephrin signaling R-HSA-3928664 7.545657e-02 1.122 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.349249e-02 1.078 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.210868e-02 1.086 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.484075e-02 1.126 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.545657e-02 1.122 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.659918e-02 1.116 0 0
Gene expression (Transcription) R-HSA-74160 8.740726e-02 1.058 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.808037e-02 1.055 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.940043e-02 1.049 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.940043e-02 1.049 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 9.156220e-02 1.038 0 0
Signaling by GSK3beta mutants R-HSA-5339716 9.156220e-02 1.038 0 0
NF-kB is activated and signals survival R-HSA-209560 9.156220e-02 1.038 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.264486e-02 1.033 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.459277e-01 0.836 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.459277e-01 0.836 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.459277e-01 0.836 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.459277e-01 0.836 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.321749e-01 0.879 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.321749e-01 0.879 0 0
C6 deamination of adenosine R-HSA-75102 1.321749e-01 0.879 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.321749e-01 0.879 0 0
Potassium transport channels R-HSA-1296067 1.321749e-01 0.879 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.705677e-01 0.568 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.705677e-01 0.568 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.705677e-01 0.568 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.705677e-01 0.568 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.705677e-01 0.568 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.705677e-01 0.568 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.705677e-01 0.568 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.705677e-01 0.568 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.705677e-01 0.568 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.705677e-01 0.568 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.705677e-01 0.568 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.705677e-01 0.568 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.705677e-01 0.568 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.705677e-01 0.568 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.705677e-01 0.568 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.003799e-01 0.998 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.003799e-01 0.998 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.003799e-01 0.998 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.003799e-01 0.998 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.871303e-01 0.728 0 0
MET activates PTPN11 R-HSA-8865999 1.871303e-01 0.728 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.341588e-01 0.872 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.240016e-01 0.907 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.240016e-01 0.907 0 0
Calcineurin activates NFAT R-HSA-2025928 1.240016e-01 0.907 0 0
CREB phosphorylation R-HSA-199920 1.712217e-01 0.766 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.712217e-01 0.766 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.712217e-01 0.766 0 0
NADE modulates death signalling R-HSA-205025 2.445316e-01 0.612 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.445316e-01 0.612 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.445316e-01 0.612 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.445316e-01 0.612 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.445316e-01 0.612 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.445316e-01 0.612 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.770243e-01 0.424 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.770243e-01 0.424 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.770243e-01 0.424 0 0
Mitochondrial transcription initiation R-HSA-163282 3.770243e-01 0.424 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.770243e-01 0.424 0 0
Intestinal infectious diseases R-HSA-8942233 3.770243e-01 0.424 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.770243e-01 0.424 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.770243e-01 0.424 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.770243e-01 0.424 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.770243e-01 0.424 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.770243e-01 0.424 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.770243e-01 0.424 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.770243e-01 0.424 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.770243e-01 0.424 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.770243e-01 0.424 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.770243e-01 0.424 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.770243e-01 0.424 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.770243e-01 0.424 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.770243e-01 0.424 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.770243e-01 0.424 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.770243e-01 0.424 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.770243e-01 0.424 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.770243e-01 0.424 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.119186e-01 0.951 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.119186e-01 0.951 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.119186e-01 0.951 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.119186e-01 0.951 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.119186e-01 0.951 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.119186e-01 0.951 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.119186e-01 0.951 0 0
Formation of apoptosome R-HSA-111458 1.520405e-01 0.818 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.520405e-01 0.818 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.520405e-01 0.818 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.520405e-01 0.818 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.001826e-01 0.999 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.107702e-01 0.676 0 0
SOS-mediated signalling R-HSA-112412 2.107702e-01 0.676 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.107702e-01 0.676 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.342468e-01 0.872 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.342468e-01 0.872 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.342468e-01 0.872 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.822111e-01 0.739 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.822111e-01 0.739 0 0
Signaling by APC mutants R-HSA-4839744 1.822111e-01 0.739 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.822111e-01 0.739 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.822111e-01 0.739 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.822111e-01 0.739 0 0
IRS activation R-HSA-74713 3.024954e-01 0.519 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 3.024954e-01 0.519 0 0
G2 Phase R-HSA-68911 3.024954e-01 0.519 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 3.024954e-01 0.519 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.024954e-01 0.519 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.046950e-01 0.980 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.046950e-01 0.980 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.046950e-01 0.980 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.046950e-01 0.980 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.046950e-01 0.980 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.583804e-01 0.800 0 0
cGMP effects R-HSA-418457 1.583804e-01 0.800 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.520406e-01 0.599 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.520406e-01 0.599 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.213041e-01 0.916 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.213041e-01 0.916 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.213041e-01 0.916 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.067244e-01 0.972 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.141441e-01 0.669 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.141441e-01 0.669 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.841263e-01 0.735 0 0
TGFBR3 expression R-HSA-9839394 1.219125e-01 0.914 0 0
Tight junction interactions R-HSA-420029 1.219125e-01 0.914 0 0
Signaling by Erythropoietin R-HSA-9006335 1.071782e-01 0.970 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.071782e-01 0.970 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.211589e-01 0.917 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.211589e-01 0.917 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.821927e-01 0.739 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.112725e-01 0.675 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.112725e-01 0.675 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.474624e-01 0.606 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.474624e-01 0.606 0 0
ARMS-mediated activation R-HSA-170984 2.943295e-01 0.531 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.943295e-01 0.531 0 0
Lipophagy R-HSA-9613354 2.943295e-01 0.531 0 0
WNT mediated activation of DVL R-HSA-201688 2.943295e-01 0.531 0 0
ALK mutants bind TKIs R-HSA-9700645 2.943295e-01 0.531 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.596357e-01 0.444 0 0
Phosphorylation of Emi1 R-HSA-176417 3.596357e-01 0.444 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.596357e-01 0.444 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.596357e-01 0.444 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.596357e-01 0.444 0 0
Signaling by MAPK mutants R-HSA-9652817 3.596357e-01 0.444 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.679494e-01 0.330 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 4.679494e-01 0.330 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.679494e-01 0.330 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.679494e-01 0.330 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.679494e-01 0.330 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.679494e-01 0.330 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.679494e-01 0.330 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.679494e-01 0.330 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.554611e-01 0.808 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.554611e-01 0.808 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.173583e-01 0.930 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.395953e-01 0.621 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.395953e-01 0.621 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.395953e-01 0.621 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.817938e-01 0.550 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.817938e-01 0.550 0 0
Formation of axial mesoderm R-HSA-9796292 2.817938e-01 0.550 0 0
mRNA 3'-end processing R-HSA-72187 9.926007e-02 1.003 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.926007e-02 1.003 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.370085e-01 0.472 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.370085e-01 0.472 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.091356e-01 0.962 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.928787e-01 0.715 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.928787e-01 0.715 0 0
Late endosomal microautophagy R-HSA-9615710 1.928787e-01 0.715 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.632234e-01 0.787 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.688652e-01 0.570 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.217300e-01 0.654 0 0
Striated Muscle Contraction R-HSA-390522 1.860568e-01 0.730 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 2.128698e-01 0.672 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.167802e-01 0.499 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.149589e-01 0.382 0 0
STAT5 Activation R-HSA-9645135 4.149589e-01 0.382 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 4.149589e-01 0.382 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 4.149589e-01 0.382 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.043044e-01 0.690 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.043044e-01 0.690 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.043044e-01 0.690 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.446556e-01 0.611 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.446556e-01 0.611 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.960892e-01 0.708 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.795310e-01 0.421 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.795310e-01 0.421 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.795310e-01 0.421 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 3.795310e-01 0.421 0 0
HIV Transcription Elongation R-HSA-167169 2.135224e-01 0.671 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.135224e-01 0.671 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.135224e-01 0.671 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.668325e-01 0.778 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.682772e-01 0.571 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.682772e-01 0.571 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.682772e-01 0.571 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.550192e-01 0.593 0 0
Erythropoietin activates RAS R-HSA-9027284 3.520859e-01 0.453 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.520859e-01 0.453 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.483060e-01 0.829 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.293335e-01 0.482 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.273137e-01 0.895 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.097460e-01 0.509 0 0
HIV elongation arrest and recovery R-HSA-167287 2.924777e-01 0.534 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.924777e-01 0.534 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.924777e-01 0.534 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.778483e-01 0.750 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.501394e-01 0.602 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.076424e-01 0.683 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.076424e-01 0.683 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.864850e-01 0.729 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.370925e-01 0.472 0 0
Deadenylation of mRNA R-HSA-429947 3.370925e-01 0.472 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.600912e-01 0.444 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 3.600912e-01 0.444 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 3.874021e-01 0.412 0 0
Phosphorylation of the APC/C R-HSA-176412 3.874021e-01 0.412 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.214333e-01 0.375 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.677785e-01 0.330 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 4.677785e-01 0.330 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.677785e-01 0.330 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.677785e-01 0.330 0 0
Netrin mediated repulsion signals R-HSA-418886 4.677785e-01 0.330 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.677785e-01 0.330 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 4.677785e-01 0.330 0 0
Disinhibition of SNARE formation R-HSA-114516 4.677785e-01 0.330 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.677785e-01 0.330 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.677785e-01 0.330 0 0
Axonal growth stimulation R-HSA-209563 5.456082e-01 0.263 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.456082e-01 0.263 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.456082e-01 0.263 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.456082e-01 0.263 0 0
Invadopodia formation R-HSA-8941237 5.456082e-01 0.263 0 0
Classical Kir channels R-HSA-1296053 5.456082e-01 0.263 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 5.456082e-01 0.263 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.456082e-01 0.263 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.456082e-01 0.263 0 0
Defective CYP1B1 causes Glaucoma R-HSA-5579000 5.456082e-01 0.263 0 0
Phenylketonuria R-HSA-2160456 5.456082e-01 0.263 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.456082e-01 0.263 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.456082e-01 0.263 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.456082e-01 0.263 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.749220e-01 0.757 0 0
Meiotic synapsis R-HSA-1221632 2.608401e-01 0.584 0 0
DAP12 signaling R-HSA-2424491 3.421427e-01 0.466 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.421427e-01 0.466 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 3.909221e-01 0.408 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.909221e-01 0.408 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.455077e-01 0.462 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.455077e-01 0.462 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 4.224503e-01 0.374 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.224503e-01 0.374 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.385621e-01 0.622 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.115864e-01 0.506 0 0
EGFR downregulation R-HSA-182971 3.673735e-01 0.435 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.923828e-01 0.406 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.623318e-01 0.335 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.623318e-01 0.335 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.623318e-01 0.335 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.623318e-01 0.335 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.216362e-01 0.375 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.169271e-01 0.499 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.169271e-01 0.499 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.682936e-01 0.571 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.682936e-01 0.571 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.337011e-01 0.477 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.569846e-01 0.340 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.569846e-01 0.340 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.569846e-01 0.340 0 0
RSK activation R-HSA-444257 5.176469e-01 0.286 0 0
Regulation by c-FLIP R-HSA-3371378 5.176469e-01 0.286 0 0
Dimerization of procaspase-8 R-HSA-69416 5.176469e-01 0.286 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 5.176469e-01 0.286 0 0
Activation of RAS in B cells R-HSA-1169092 5.176469e-01 0.286 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 5.176469e-01 0.286 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 5.176469e-01 0.286 0 0
FGFR1b ligand binding and activation R-HSA-190370 5.176469e-01 0.286 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 5.176469e-01 0.286 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.053956e-01 0.515 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.696702e-01 0.432 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.180696e-01 0.379 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.520599e-01 0.345 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.520599e-01 0.345 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.190104e-01 0.496 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.190104e-01 0.496 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.475272e-01 0.349 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.475272e-01 0.349 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.433241e-01 0.353 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.393957e-01 0.357 0 0
GAB1 signalosome R-HSA-180292 4.907918e-01 0.309 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.747246e-01 0.324 0 0
Transcription of the HIV genome R-HSA-167172 4.226392e-01 0.374 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.627487e-01 0.335 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.529586e-01 0.344 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.184038e-01 0.378 0 0
Viral mRNA Translation R-HSA-192823 4.360397e-01 0.360 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.794425e-01 0.319 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.015218e-01 0.300 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.114271e-01 0.291 0 0
Regulation of signaling by CBL R-HSA-912631 5.236910e-01 0.281 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.236910e-01 0.281 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.236910e-01 0.281 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.399538e-01 0.268 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.399538e-01 0.268 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.399538e-01 0.268 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.399538e-01 0.268 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.643006e-01 0.248 0 0
CASP8 activity is inhibited R-HSA-5218900 5.643006e-01 0.248 0 0
snRNP Assembly R-HSA-191859 4.878255e-01 0.312 0 0
Metabolism of non-coding RNA R-HSA-194441 4.878255e-01 0.312 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.742226e-01 0.324 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.087750e-01 0.293 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.087750e-01 0.293 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.946101e-01 0.306 0 0
Translation initiation complex formation R-HSA-72649 5.143953e-01 0.289 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.401106e-01 0.268 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.330859e-01 0.273 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.541697e-01 0.256 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.371728e-01 0.863 0 0
Signaling by EGFR R-HSA-177929 2.171668e-01 0.663 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.660180e-01 0.575 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.767382e-01 0.322 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.767382e-01 0.322 0 0
ESR-mediated signaling R-HSA-8939211 1.360525e-01 0.866 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.156112e-01 0.666 0 0
Downstream TCR signaling R-HSA-202424 4.949153e-01 0.305 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.193918e-01 0.496 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.156147e-01 0.501 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.053268e-01 0.977 0 0
IGF1R signaling cascade R-HSA-2428924 1.726871e-01 0.763 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.560315e-01 0.592 0 0
Aggrephagy R-HSA-9646399 2.135224e-01 0.671 0 0
Specification of the neural plate border R-HSA-9834899 3.293335e-01 0.482 0 0
G-protein beta:gamma signalling R-HSA-397795 2.770041e-01 0.558 0 0
HATs acetylate histones R-HSA-3214847 2.188454e-01 0.660 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.793076e-01 0.746 0 0
Formation of definitive endoderm R-HSA-9823730 2.059552e-01 0.686 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.159691e-01 0.936 0 0
Insulin receptor signalling cascade R-HSA-74751 4.633521e-01 0.334 0 0
Diseases of programmed cell death R-HSA-9645723 9.550313e-02 1.020 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.520405e-01 0.818 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.629743e-01 0.580 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.068208e-01 0.391 0 0
Interleukin-1 signaling R-HSA-9020702 4.064423e-01 0.391 0 0
Signaling by FGFR2 R-HSA-5654738 5.231077e-01 0.281 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.874021e-01 0.412 0 0
RUNX2 regulates bone development R-HSA-8941326 3.688848e-01 0.433 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.450305e-02 1.025 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.370085e-01 0.472 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.600912e-01 0.444 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.569846e-01 0.340 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.506643e-01 0.455 0 0
Degradation of CDH1 R-HSA-9766229 5.433758e-01 0.265 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.156378e-01 0.381 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.148353e-01 0.502 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.032116e-01 0.692 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 2.107702e-01 0.676 0 0
mRNA Editing R-HSA-75072 2.943295e-01 0.531 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.395953e-01 0.621 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.210817e-01 0.655 0 0
IRS-mediated signalling R-HSA-112399 4.486120e-01 0.348 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.111089e-01 0.507 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.937595e-01 0.405 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.749559e-01 0.757 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.881979e-01 0.725 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.524912e-01 0.817 0 0
DNA Double Strand Break Response R-HSA-5693606 2.123781e-01 0.673 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.475272e-01 0.349 0 0
Meiosis R-HSA-1500620 3.979800e-01 0.400 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.643006e-01 0.248 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.184893e-01 0.926 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.214333e-01 0.375 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.565347e-01 0.255 0 0
TNF signaling R-HSA-75893 1.421272e-01 0.847 0 0
Signaling by FGFR3 R-HSA-5654741 2.210817e-01 0.655 0 0
Signal attenuation R-HSA-74749 1.520405e-01 0.818 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.333061e-01 0.875 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.608401e-01 0.584 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.971832e-01 0.705 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.186864e-01 0.497 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 4.683856e-01 0.329 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.858983e-01 0.313 0 0
Homology Directed Repair R-HSA-5693538 2.698921e-01 0.569 0 0
Signaling by FGFR4 R-HSA-5654743 1.882406e-01 0.725 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.518904e-01 0.818 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.860568e-01 0.730 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.032116e-01 0.692 0 0
MHC class II antigen presentation R-HSA-2132295 2.590918e-01 0.587 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.854783e-01 0.732 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.943295e-01 0.531 1 1
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.685673e-01 0.773 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.370085e-01 0.472 0 0
MAP2K and MAPK activation R-HSA-5674135 2.501394e-01 0.602 0 0
Signaling by FGFR1 R-HSA-5654736 3.138729e-01 0.503 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.003771e-01 0.522 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 5.176469e-01 0.286 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.186864e-01 0.497 0 0
PI3K Cascade R-HSA-109704 4.321986e-01 0.364 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.033905e-01 0.692 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.587623e-01 0.338 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.592609e-01 0.798 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.532242e-01 0.596 0 0
Apoptotic factor-mediated response R-HSA-111471 1.596063e-01 0.797 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.224503e-01 0.374 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.326321e-01 0.633 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.747246e-01 0.324 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.445316e-01 0.612 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.107702e-01 0.676 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.596357e-01 0.444 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.596357e-01 0.444 0 0
Regulation of CDH11 function R-HSA-9762292 3.370085e-01 0.472 0 0
PI3K/AKT activation R-HSA-198203 3.370085e-01 0.472 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.712661e-02 1.013 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.793076e-01 0.746 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 3.520859e-01 0.453 0 0
Peptide chain elongation R-HSA-156902 1.415127e-01 0.849 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.206460e-01 0.918 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.032633e-01 0.692 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 5.176469e-01 0.286 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.643006e-01 0.248 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 5.643006e-01 0.248 0 0
Regulated Necrosis R-HSA-5218859 1.001183e-01 0.999 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.865347e-01 0.413 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.260766e-01 0.487 0 0
Diseases of Immune System R-HSA-5260271 3.260766e-01 0.487 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.501155e-01 0.456 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.293335e-01 0.482 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.275302e-01 0.278 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.624392e-01 0.441 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.641025e-01 0.785 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.216362e-01 0.375 0 0
Interleukin-9 signaling R-HSA-8985947 5.176469e-01 0.286 0 0
Generation of second messenger molecules R-HSA-202433 1.301323e-01 0.886 0 0
Triglyceride catabolism R-HSA-163560 3.688848e-01 0.433 0 0
Mismatch Repair R-HSA-5358508 4.907918e-01 0.309 0 0
Signaling by WNT R-HSA-195721 5.284330e-01 0.277 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.641025e-01 0.785 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.377862e-01 0.359 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.554611e-01 0.808 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.624392e-01 0.441 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.624392e-01 0.441 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.599760e-01 0.444 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.324524e-01 0.634 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.445462e-01 0.352 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.275302e-01 0.278 0 0
Autophagy R-HSA-9612973 1.652501e-01 0.782 0 0
Adrenoceptors R-HSA-390696 9.844053e-02 1.007 0 0
Dopamine receptors R-HSA-390651 2.445316e-01 0.612 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.445316e-01 0.612 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 3.024954e-01 0.519 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.520406e-01 0.599 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.943295e-01 0.531 0 0
Signaling by WNT in cancer R-HSA-4791275 2.550192e-01 0.593 0 0
Selective autophagy R-HSA-9663891 1.415127e-01 0.849 0 0
Sodium/Calcium exchangers R-HSA-425561 4.214333e-01 0.375 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.623318e-01 0.335 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.623318e-01 0.335 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 5.176469e-01 0.286 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.820365e-01 0.317 0 0
Platelet calcium homeostasis R-HSA-418360 4.747246e-01 0.324 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.236910e-01 0.281 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.175783e-01 0.286 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.622567e-01 0.790 1 0
Signaling by FGFR1 in disease R-HSA-5655302 1.578352e-01 0.802 0 0
Mitophagy R-HSA-5205647 4.683856e-01 0.329 0 0
Prolonged ERK activation events R-HSA-169893 3.874021e-01 0.412 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.946101e-01 0.306 0 0
Mitotic Prophase R-HSA-68875 3.705700e-01 0.431 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.462711e-01 0.461 0 0
Cellular response to chemical stress R-HSA-9711123 3.160132e-01 0.500 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.446556e-01 0.611 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.712217e-01 0.766 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.370085e-01 0.472 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.860568e-01 0.730 0 0
Repression of WNT target genes R-HSA-4641265 4.623318e-01 0.335 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.475272e-01 0.349 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.747246e-01 0.324 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 4.747246e-01 0.324 0 0
PTEN Regulation R-HSA-6807070 4.953387e-01 0.305 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 2.112725e-01 0.675 0 0
GPER1 signaling R-HSA-9634597 2.741821e-01 0.562 0 0
Cilium Assembly R-HSA-5617833 1.653315e-01 0.782 0 0
Potassium Channels R-HSA-1296071 4.241539e-01 0.372 0 0
Macroautophagy R-HSA-1632852 2.935905e-01 0.532 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.333061e-01 0.875 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.168165e-01 0.664 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.168165e-01 0.664 0 0
Activation of BH3-only proteins R-HSA-114452 2.128698e-01 0.672 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.156697e-01 0.381 0 0
Integration of energy metabolism R-HSA-163685 4.568735e-01 0.340 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.578504e-01 0.339 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.533109e-01 0.257 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.871303e-01 0.728 0 0
Sensory perception of sour taste R-HSA-9729555 2.445316e-01 0.612 0 0
Ca2+ activated K+ channels R-HSA-1296052 2.107702e-01 0.676 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.046950e-01 0.980 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.679494e-01 0.330 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.167802e-01 0.499 0 0
Abacavir transmembrane transport R-HSA-2161517 4.149589e-01 0.382 0 0
Cardiogenesis R-HSA-9733709 2.770041e-01 0.558 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.770041e-01 0.558 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.994754e-01 0.524 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.370925e-01 0.472 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.214333e-01 0.375 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.909221e-01 0.408 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.840855e-01 0.547 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 5.176469e-01 0.286 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 5.176469e-01 0.286 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.576442e-01 0.339 0 0
Signaling by Hedgehog R-HSA-5358351 3.284615e-01 0.484 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.820079e-01 0.418 0 0
S Phase R-HSA-69242 3.865347e-01 0.413 0 0
Interleukin-1 family signaling R-HSA-446652 1.798268e-01 0.745 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.377812e-01 0.861 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.685673e-01 0.773 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.421427e-01 0.466 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.224503e-01 0.374 0 0
Recycling pathway of L1 R-HSA-437239 5.010337e-01 0.300 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.685673e-01 0.773 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.392043e-01 0.470 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.520859e-01 0.453 0 0
RMTs methylate histone arginines R-HSA-3214858 4.356985e-01 0.361 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.433758e-01 0.265 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.433758e-01 0.265 0 0
Neuronal System R-HSA-112316 1.956819e-01 0.708 1 0
Interleukin-2 signaling R-HSA-9020558 3.795310e-01 0.421 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.952473e-01 0.305 0 0
Cell junction organization R-HSA-446728 1.076224e-01 0.968 0 0
Signaling by FGFR in disease R-HSA-1226099 5.299108e-01 0.276 0 0
Regulation of KIT signaling R-HSA-1433559 1.583804e-01 0.800 0 0
mTORC1-mediated signalling R-HSA-166208 1.582395e-01 0.801 0 0
Pyroptosis R-HSA-5620971 2.924777e-01 0.534 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.874021e-01 0.412 0 0
G2/M Checkpoints R-HSA-69481 2.488319e-01 0.604 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.799539e-01 0.553 0 0
Adherens junctions interactions R-HSA-418990 4.920338e-01 0.308 0 0
Cell-cell junction organization R-HSA-421270 3.281317e-01 0.484 0 0
Transmission across Chemical Synapses R-HSA-112315 4.695320e-01 0.328 1 0
DNA Repair R-HSA-73894 4.625675e-01 0.335 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.436319e-01 0.843 0 0
Frs2-mediated activation R-HSA-170968 5.019185e-01 0.299 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.911889e-01 0.719 0 0
Interleukin-2 family signaling R-HSA-451927 2.135224e-01 0.671 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.392829e-01 0.856 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 2.383154e-01 0.623 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 2.383154e-01 0.623 0 0
Signaling by TGFB family members R-HSA-9006936 1.517583e-01 0.819 0 0
Formation of intermediate mesoderm R-HSA-9761174 3.370085e-01 0.472 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.795310e-01 0.421 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.520859e-01 0.453 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.677785e-01 0.330 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.799539e-01 0.553 0 0
Eukaryotic Translation Termination R-HSA-72764 3.194187e-01 0.496 0 0
Vesicle-mediated transport R-HSA-5653656 3.980364e-01 0.400 0 0
Metabolism of RNA R-HSA-8953854 5.483642e-01 0.261 0 0
Hedgehog 'on' state R-HSA-5632684 3.677816e-01 0.434 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.128698e-01 0.672 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.778483e-01 0.750 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.149344e-01 0.502 0 0
Deubiquitination R-HSA-5688426 4.826374e-01 0.316 0 0
Negative regulation of FLT3 R-HSA-9706369 2.112725e-01 0.675 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.441898e-01 0.612 0 0
PECAM1 interactions R-HSA-210990 1.822111e-01 0.739 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.141441e-01 0.669 0 0
Neurofascin interactions R-HSA-447043 4.149589e-01 0.382 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.264448e-01 0.645 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.415527e-01 0.266 0 0
Signaling by TGFBR3 R-HSA-9839373 2.383154e-01 0.623 0 0
Downstream signal transduction R-HSA-186763 1.360740e-01 0.866 0 0
Heme signaling R-HSA-9707616 9.436351e-02 1.025 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.436351e-02 1.025 0 0
Protein methylation R-HSA-8876725 3.520859e-01 0.453 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.331950e-01 0.477 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.445462e-01 0.352 0 0
Signaling by PTK6 R-HSA-8848021 4.445462e-01 0.352 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.770041e-01 0.558 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.854417e-01 0.732 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 4.569846e-01 0.340 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.534583e-01 0.257 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.598032e-01 0.585 0 0
FLT3 signaling in disease R-HSA-9682385 2.428297e-01 0.615 0 0
Sensory processing of sound R-HSA-9659379 2.200787e-01 0.657 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.321270e-01 0.479 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.171388e-01 0.499 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.520599e-01 0.345 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.478776e-01 0.830 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.814346e-01 0.551 0 0
MAP kinase activation R-HSA-450294 5.263838e-01 0.279 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.501394e-01 0.602 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.727152e-01 0.763 0 0
MTF1 activates gene expression R-HSA-5660489 2.445316e-01 0.612 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.445316e-01 0.612 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.770243e-01 0.424 0 0
Regulation of PTEN localization R-HSA-8948747 2.107702e-01 0.676 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.520406e-01 0.599 0 0
Co-stimulation by ICOS R-HSA-9927354 2.520406e-01 0.599 0 0
Signaling by AXIN mutants R-HSA-4839735 2.141441e-01 0.669 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.141441e-01 0.669 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.841263e-01 0.735 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.596063e-01 0.797 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.943295e-01 0.531 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 3.596357e-01 0.444 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.596357e-01 0.444 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.679494e-01 0.330 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.679494e-01 0.330 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.564153e-01 0.591 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.988528e-01 0.525 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.795310e-01 0.421 0 0
Differentiation of T cells R-HSA-9945266 3.874021e-01 0.412 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 3.874021e-01 0.412 0 0
MET interacts with TNS proteins R-HSA-8875513 5.456082e-01 0.263 0 0
Disorders of Developmental Biology R-HSA-9675151 4.224503e-01 0.374 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.138729e-01 0.503 0 0
Signaling by ERBB4 R-HSA-1236394 3.178953e-01 0.498 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.445462e-01 0.352 0 0
Signaling by NTRKs R-HSA-166520 1.484384e-01 0.828 0 0
GPVI-mediated activation cascade R-HSA-114604 2.428297e-01 0.615 0 0
Reproduction R-HSA-1474165 5.305455e-01 0.275 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.232212e-01 0.651 0 0
Formation of the nephric duct R-HSA-9830364 3.646872e-01 0.438 0 0
Regulation of insulin secretion R-HSA-422356 5.511254e-01 0.259 0 0
Amine ligand-binding receptors R-HSA-375280 4.356985e-01 0.361 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.287822e-01 0.483 0 0
L1CAM interactions R-HSA-373760 1.352301e-01 0.869 0 0
Signaling by NOTCH3 R-HSA-9012852 5.344303e-01 0.272 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.520859e-01 0.453 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.391749e-01 0.856 0 0
Interleukin-6 signaling R-HSA-1059683 2.817938e-01 0.550 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.424138e-01 0.465 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.458814e-01 0.263 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.450305e-02 1.025 0 0
G0 and Early G1 R-HSA-1538133 1.518904e-01 0.818 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.223407e-01 0.492 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 5.643006e-01 0.248 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.568796e-01 0.804 0 0
Smooth Muscle Contraction R-HSA-445355 3.696702e-01 0.432 0 0
Stimuli-sensing channels R-HSA-2672351 3.462711e-01 0.461 0 0
Glycolysis R-HSA-70171 1.679264e-01 0.775 0 0
Tie2 Signaling R-HSA-210993 2.988528e-01 0.525 0 0
Selenocysteine synthesis R-HSA-2408557 3.193918e-01 0.496 0 0
Signaling by KIT in disease R-HSA-9669938 4.520599e-01 0.345 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.071782e-01 0.970 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.692129e-01 0.570 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.677816e-01 0.434 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 9.844053e-02 1.007 0 0
Interleukin-1 processing R-HSA-448706 1.240016e-01 0.907 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 3.024954e-01 0.519 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.784167e-01 0.749 0 0
RAB geranylgeranylation R-HSA-8873719 1.935660e-01 0.713 0 0
CHL1 interactions R-HSA-447041 4.677785e-01 0.330 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.623318e-01 0.335 0 0
Disorders of Nervous System Development R-HSA-9697154 4.623318e-01 0.335 0 0
Pervasive developmental disorders R-HSA-9005895 4.623318e-01 0.335 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.520599e-01 0.345 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.019185e-01 0.299 0 0
Protein hydroxylation R-HSA-9629569 5.555328e-01 0.255 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.117153e-01 0.291 0 0
Diseases of DNA repair R-HSA-9675135 2.383154e-01 0.623 0 0
Signaling by ALK R-HSA-201556 1.960892e-01 0.708 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.107702e-01 0.676 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.019185e-01 0.299 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.216362e-01 0.375 0 0
Signal transduction by L1 R-HSA-445144 5.555328e-01 0.255 0 0
Aquaporin-mediated transport R-HSA-445717 5.263838e-01 0.279 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.213041e-01 0.916 0 0
Other interleukin signaling R-HSA-449836 1.821927e-01 0.739 0 0
Interleukin-15 signaling R-HSA-8983432 2.474624e-01 0.606 0 0
DSCAM interactions R-HSA-376172 4.679494e-01 0.330 0 0
Tandem pore domain potassium channels R-HSA-1296346 3.370085e-01 0.472 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.456082e-01 0.263 0 0
Syndecan interactions R-HSA-3000170 4.820365e-01 0.317 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.763982e-01 0.424 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.736121e-01 0.325 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.794425e-01 0.319 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.399538e-01 0.268 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.143953e-01 0.289 0 0
Specification of primordial germ cells R-HSA-9827857 1.383315e-01 0.859 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.821927e-01 0.739 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.381340e-01 0.471 0 0
Glucose metabolism R-HSA-70326 3.314731e-01 0.480 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.015218e-01 0.300 0 0
Histamine receptors R-HSA-390650 5.456082e-01 0.263 0 0
Interleukin-7 signaling R-HSA-1266695 5.401106e-01 0.268 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.596357e-01 0.444 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.679494e-01 0.330 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.677785e-01 0.330 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.456082e-01 0.263 0 0
Regulation of beta-cell development R-HSA-186712 4.878255e-01 0.312 0 0
Interleukin-12 family signaling R-HSA-447115 2.628500e-01 0.580 0 0
PKR-mediated signaling R-HSA-9833482 5.231077e-01 0.281 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.167802e-01 0.499 0 0
Platelet sensitization by LDL R-HSA-432142 4.907918e-01 0.309 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.643006e-01 0.248 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.643006e-01 0.248 0 0
Signaling by Leptin R-HSA-2586552 3.370085e-01 0.472 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.841263e-01 0.735 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.677785e-01 0.330 0 0
FasL/ CD95L signaling R-HSA-75157 5.456082e-01 0.263 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.643006e-01 0.248 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.916242e-01 0.535 0 0
Interleukin-12 signaling R-HSA-9020591 1.824196e-01 0.739 0 0
HDL assembly R-HSA-8963896 5.399538e-01 0.268 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.679837e-01 0.246 0 0
Metalloprotease DUBs R-HSA-5689901 5.679837e-01 0.246 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.682541e-01 0.245 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.682541e-01 0.245 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.762598e-01 0.239 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.762598e-01 0.239 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.762598e-01 0.239 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.762598e-01 0.239 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.762598e-01 0.239 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.762598e-01 0.239 0 0
Formation of the anterior neural plate R-HSA-9823739 5.762598e-01 0.239 0 0
Nuclear RNA decay R-HSA-9930044 5.785792e-01 0.238 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.785792e-01 0.238 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.785792e-01 0.238 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.785792e-01 0.238 0 0
Ion channel transport R-HSA-983712 5.803081e-01 0.236 0 0
Ion transport by P-type ATPases R-HSA-936837 5.823104e-01 0.235 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.843864e-01 0.233 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 5.861970e-01 0.232 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 5.861970e-01 0.232 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.861970e-01 0.232 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.903867e-01 0.229 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.907550e-01 0.229 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.926083e-01 0.227 0 0
Host Interactions of HIV factors R-HSA-162909 5.947110e-01 0.226 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.949599e-01 0.226 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 5.949599e-01 0.226 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.949599e-01 0.226 0 0
Cristae formation R-HSA-8949613 5.949599e-01 0.226 0 0
Insulin processing R-HSA-264876 5.949599e-01 0.226 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.956025e-01 0.225 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.963527e-01 0.224 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.028988e-01 0.220 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.040781e-01 0.219 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.076155e-01 0.216 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.076155e-01 0.216 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.076155e-01 0.216 0 0
Arachidonate production from DAG R-HSA-426048 6.076155e-01 0.216 0 0
Pexophagy R-HSA-9664873 6.076155e-01 0.216 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 6.076155e-01 0.216 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 6.076155e-01 0.216 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.076155e-01 0.216 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.107124e-01 0.214 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.107124e-01 0.214 0 0
HCN channels R-HSA-1296061 6.119356e-01 0.213 0 0
ATP sensitive Potassium channels R-HSA-1296025 6.119356e-01 0.213 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 6.119356e-01 0.213 0 0
Defective MAT1A causes MATD R-HSA-5579024 6.119356e-01 0.213 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 6.119356e-01 0.213 0 0
Regulation of gap junction activity R-HSA-191650 6.119356e-01 0.213 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 6.119356e-01 0.213 0 0
Transmission across Electrical Synapses R-HSA-112307 6.119356e-01 0.213 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 6.119356e-01 0.213 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 6.119356e-01 0.213 0 0
MDK and PTN in ALK signaling R-HSA-9851151 6.119356e-01 0.213 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.119356e-01 0.213 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.125330e-01 0.213 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.155908e-01 0.211 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.155908e-01 0.211 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.155908e-01 0.211 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 6.155908e-01 0.211 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.160407e-01 0.210 0 0
Ub-specific processing proteases R-HSA-5689880 6.176784e-01 0.209 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.179512e-01 0.209 0 0
G1/S Transition R-HSA-69206 6.204968e-01 0.207 0 0
Telomere Extension By Telomerase R-HSA-171319 6.209690e-01 0.207 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.209690e-01 0.207 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.234038e-01 0.205 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.240268e-01 0.205 0 0
Ca2+ pathway R-HSA-4086398 6.242420e-01 0.205 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.242420e-01 0.205 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.264352e-01 0.203 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.294393e-01 0.201 0 0
Signaling by MET R-HSA-6806834 6.302116e-01 0.201 0 0
Kidney development R-HSA-9830369 6.351700e-01 0.197 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.383551e-01 0.195 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.432341e-01 0.192 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.432341e-01 0.192 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.432341e-01 0.192 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.432341e-01 0.192 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.436463e-01 0.191 0 0
Notch-HLH transcription pathway R-HSA-350054 6.436463e-01 0.191 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.436463e-01 0.191 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 6.436463e-01 0.191 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.436463e-01 0.191 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.436463e-01 0.191 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.459563e-01 0.190 0 0
HIV Infection R-HSA-162906 6.461741e-01 0.190 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.475723e-01 0.189 0 0
FGFR2b ligand binding and activation R-HSA-190377 6.475723e-01 0.189 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 6.475723e-01 0.189 0 0
Formation of the posterior neural plate R-HSA-9832991 6.475723e-01 0.189 0 0
Bicarbonate transporters R-HSA-425381 6.475723e-01 0.189 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 6.475723e-01 0.189 0 0
LGI-ADAM interactions R-HSA-5682910 6.475723e-01 0.189 0 0
Transport of RCbl within the body R-HSA-9758890 6.475723e-01 0.189 0 0
Synthesis of PI R-HSA-1483226 6.475723e-01 0.189 0 0
Signalling to ERKs R-HSA-187687 6.491440e-01 0.188 0 0
Oncogene Induced Senescence R-HSA-2559585 6.491440e-01 0.188 0 0
Intra-Golgi traffic R-HSA-6811438 6.527624e-01 0.185 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.566429e-01 0.183 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.644467e-01 0.178 0 0
Signaling by PDGF R-HSA-186797 6.644467e-01 0.178 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.685844e-01 0.175 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.685844e-01 0.175 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.685844e-01 0.175 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.685844e-01 0.175 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.685844e-01 0.175 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.685844e-01 0.175 0 0
Activation of AKT2 R-HSA-165158 6.685844e-01 0.175 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.685844e-01 0.175 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.685844e-01 0.175 0 0
PTK6 Down-Regulation R-HSA-8849472 6.685844e-01 0.175 0 0
Co-inhibition by BTLA R-HSA-9927353 6.685844e-01 0.175 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.685844e-01 0.175 0 0
Activation of the pre-replicative complex R-HSA-68962 6.698810e-01 0.174 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.698810e-01 0.174 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.700105e-01 0.174 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.703181e-01 0.174 0 0
Growth hormone receptor signaling R-HSA-982772 6.703181e-01 0.174 0 0
Neutrophil degranulation R-HSA-6798695 6.703886e-01 0.174 0 0
G1/S-Specific Transcription R-HSA-69205 6.709908e-01 0.173 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 6.709908e-01 0.173 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.737867e-01 0.171 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.737867e-01 0.171 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.737867e-01 0.171 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.737867e-01 0.171 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.737867e-01 0.171 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.782373e-01 0.169 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.842282e-01 0.165 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 6.842282e-01 0.165 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.842282e-01 0.165 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.842282e-01 0.165 0 0
ERKs are inactivated R-HSA-202670 6.842282e-01 0.165 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.842282e-01 0.165 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.842282e-01 0.165 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.842282e-01 0.165 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.842282e-01 0.165 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.842282e-01 0.165 0 0
Interleukin-17 signaling R-HSA-448424 6.843008e-01 0.165 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.874484e-01 0.163 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.906235e-01 0.161 0 0
Voltage gated Potassium channels R-HSA-1296072 6.919497e-01 0.160 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 6.927156e-01 0.159 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 6.927156e-01 0.159 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.927156e-01 0.159 0 0
Regulation of CDH1 Function R-HSA-9764561 6.953957e-01 0.158 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.955806e-01 0.158 0 0
Complex III assembly R-HSA-9865881 6.955806e-01 0.158 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.955806e-01 0.158 0 0
Interleukin-6 family signaling R-HSA-6783589 6.955806e-01 0.158 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.969732e-01 0.157 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.000120e-01 0.155 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.023651e-01 0.153 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.023651e-01 0.153 0 0
Nephron development R-HSA-9831926 7.023651e-01 0.153 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.023651e-01 0.153 0 0
G1 Phase R-HSA-69236 7.111059e-01 0.148 0 0
Cyclin D associated events in G1 R-HSA-69231 7.111059e-01 0.148 0 0
DAP12 interactions R-HSA-2172127 7.111059e-01 0.148 0 0
MET promotes cell motility R-HSA-8875878 7.120038e-01 0.148 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.120038e-01 0.148 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.120038e-01 0.148 0 0
Potential therapeutics for SARS R-HSA-9679191 7.138037e-01 0.146 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.144440e-01 0.146 0 0
PKB-mediated events R-HSA-109703 7.169666e-01 0.145 0 0
PDE3B signalling R-HSA-165160 7.169666e-01 0.145 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 7.169666e-01 0.145 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.169666e-01 0.145 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.169666e-01 0.145 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 7.169666e-01 0.145 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 7.169666e-01 0.145 0 0
Signaling by RNF43 mutants R-HSA-5340588 7.169666e-01 0.145 0 0
Terminal pathway of complement R-HSA-166665 7.169666e-01 0.145 0 0
Signaling by MST1 R-HSA-8852405 7.169666e-01 0.145 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 7.169666e-01 0.145 0 0
Pentose phosphate pathway disease R-HSA-6791465 7.169666e-01 0.145 0 0
Ceramide signalling R-HSA-193681 7.169666e-01 0.145 0 0
Synthesis of PS R-HSA-1483101 7.169666e-01 0.145 0 0
Formation of the Editosome R-HSA-75094 7.169666e-01 0.145 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 7.169666e-01 0.145 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 7.169666e-01 0.145 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.169666e-01 0.145 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 7.169666e-01 0.145 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 7.169666e-01 0.145 0 0
TRAIL signaling R-HSA-75158 7.169666e-01 0.145 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 7.169666e-01 0.145 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 7.169666e-01 0.145 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.176955e-01 0.144 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.176955e-01 0.144 0 0
MET activates RAS signaling R-HSA-8851805 7.176955e-01 0.144 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.176955e-01 0.144 0 0
Regulation of IFNG signaling R-HSA-877312 7.176955e-01 0.144 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.176955e-01 0.144 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.176955e-01 0.144 0 0
Leading Strand Synthesis R-HSA-69109 7.176955e-01 0.144 0 0
Polymerase switching R-HSA-69091 7.176955e-01 0.144 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.176955e-01 0.144 0 0
OAS antiviral response R-HSA-8983711 7.176955e-01 0.144 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.176955e-01 0.144 0 0
Ribosome-associated quality control R-HSA-9948299 7.182735e-01 0.144 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.194256e-01 0.143 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.194256e-01 0.143 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.194256e-01 0.143 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.194256e-01 0.143 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.194256e-01 0.143 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.194256e-01 0.143 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.267922e-01 0.139 0 0
Cellular response to starvation R-HSA-9711097 7.267922e-01 0.139 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.279457e-01 0.138 0 0
Triglyceride metabolism R-HSA-8979227 7.279457e-01 0.138 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.280748e-01 0.138 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.289910e-01 0.137 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.293436e-01 0.137 0 0
Toll-like Receptor Cascades R-HSA-168898 7.313039e-01 0.136 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 7.350609e-01 0.134 0 0
Signaling by FGFR R-HSA-190236 7.351779e-01 0.134 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.370063e-01 0.133 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.370063e-01 0.133 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.438888e-01 0.128 0 0
Influenza Infection R-HSA-168255 7.440008e-01 0.128 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.442669e-01 0.128 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.461486e-01 0.127 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.461486e-01 0.127 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.461486e-01 0.127 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.481239e-01 0.126 0 0
Acetylcholine binding and downstream events R-HSA-181431 7.481239e-01 0.126 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 7.481239e-01 0.126 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.481239e-01 0.126 0 0
FGFR2c ligand binding and activation R-HSA-190375 7.481239e-01 0.126 0 0
FGFR1c ligand binding and activation R-HSA-190373 7.481239e-01 0.126 0 0
FGFR4 ligand binding and activation R-HSA-190322 7.481239e-01 0.126 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.481239e-01 0.126 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 7.481239e-01 0.126 0 0
rRNA modification in the mitochondrion R-HSA-6793080 7.481239e-01 0.126 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.481239e-01 0.126 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.481239e-01 0.126 0 0
FGFR3 mutant receptor activation R-HSA-2033514 7.481239e-01 0.126 0 0
Maturation of nucleoprotein R-HSA-9683610 7.481239e-01 0.126 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.481239e-01 0.126 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.493658e-01 0.125 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.493658e-01 0.125 0 0
Mitochondrial biogenesis R-HSA-1592230 7.517988e-01 0.124 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.537076e-01 0.123 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.537076e-01 0.123 0 0
Signaling by NODAL R-HSA-1181150 7.537076e-01 0.123 0 0
Negative regulation of MET activity R-HSA-6807004 7.537076e-01 0.123 0 0
Creatine metabolism R-HSA-71288 7.537076e-01 0.123 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.545702e-01 0.122 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 7.545702e-01 0.122 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.582879e-01 0.120 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.582879e-01 0.120 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.582879e-01 0.120 0 0
Hydrolysis of LPE R-HSA-1483152 7.582879e-01 0.120 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.582879e-01 0.120 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.582879e-01 0.120 0 0
Signaling by LTK in cancer R-HSA-9842640 7.582879e-01 0.120 0 0
NADPH regeneration R-HSA-389542 7.582879e-01 0.120 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.582879e-01 0.120 0 0
Lipid particle organization R-HSA-8964572 7.582879e-01 0.120 0 0
Leukotriene receptors R-HSA-391906 7.582879e-01 0.120 0 0
Platelet homeostasis R-HSA-418346 7.599205e-01 0.119 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.666750e-01 0.115 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.694145e-01 0.114 0 0
Gastrulation R-HSA-9758941 7.699649e-01 0.114 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.722536e-01 0.112 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.729840e-01 0.112 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.729840e-01 0.112 0 0
Nuclear import of Rev protein R-HSA-180746 7.729840e-01 0.112 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.729840e-01 0.112 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.738378e-01 0.111 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.738378e-01 0.111 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.738378e-01 0.111 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.746045e-01 0.111 0 0
HDACs deacetylate histones R-HSA-3214815 7.746045e-01 0.111 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.746045e-01 0.111 0 0
Removal of the Flap Intermediate R-HSA-69166 7.756871e-01 0.110 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.756871e-01 0.110 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.756871e-01 0.110 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.756871e-01 0.110 0 0
Prolactin receptor signaling R-HSA-1170546 7.756871e-01 0.110 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.756871e-01 0.110 0 0
FGFR3c ligand binding and activation R-HSA-190372 7.756871e-01 0.110 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.756871e-01 0.110 0 0
Signal regulatory protein family interactions R-HSA-391160 7.756871e-01 0.110 0 0
Physiological factors R-HSA-5578768 7.756871e-01 0.110 0 0
ERK/MAPK targets R-HSA-198753 7.765754e-01 0.110 0 0
Basigin interactions R-HSA-210991 7.765754e-01 0.110 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.765754e-01 0.110 0 0
HIV Life Cycle R-HSA-162587 7.804341e-01 0.108 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.825850e-01 0.106 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.825850e-01 0.106 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.825850e-01 0.106 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.830800e-01 0.106 0 0
HIV Transcription Initiation R-HSA-167161 7.830800e-01 0.106 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.830800e-01 0.106 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.830800e-01 0.106 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.903212e-01 0.102 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.918261e-01 0.101 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 7.928708e-01 0.101 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.935786e-01 0.100 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.935786e-01 0.100 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.935786e-01 0.100 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.935786e-01 0.100 0 0
Recycling of eIF2:GDP R-HSA-72731 7.935786e-01 0.100 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.935786e-01 0.100 0 0
PTK6 Expression R-HSA-8849473 7.935786e-01 0.100 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.935786e-01 0.100 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.935786e-01 0.100 0 0
Glycoprotein hormones R-HSA-209822 7.935786e-01 0.100 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.935786e-01 0.100 0 0
Maturation of replicase proteins R-HSA-9694301 7.935786e-01 0.100 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.976672e-01 0.098 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.976672e-01 0.098 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.985949e-01 0.098 0 0
Developmental Biology R-HSA-1266738 7.998821e-01 0.097 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.005732e-01 0.097 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.005732e-01 0.097 0 0
Translesion synthesis by REV1 R-HSA-110312 8.005732e-01 0.097 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.005732e-01 0.097 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.005732e-01 0.097 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.005732e-01 0.097 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.005732e-01 0.097 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.005732e-01 0.097 0 0
FGFR3 ligand binding and activation R-HSA-190239 8.005732e-01 0.097 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.005732e-01 0.097 0 0
Other semaphorin interactions R-HSA-416700 8.005732e-01 0.097 0 0
DNA Damage Reversal R-HSA-73942 8.005732e-01 0.097 0 0
mRNA Capping R-HSA-72086 8.009445e-01 0.096 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.009445e-01 0.096 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.059407e-01 0.094 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.066068e-01 0.093 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.069143e-01 0.093 0 0
SARS-CoV Infections R-HSA-9679506 8.131413e-01 0.090 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.132379e-01 0.090 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.149941e-01 0.089 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.150219e-01 0.089 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.150588e-01 0.089 0 0
FGFR2 alternative splicing R-HSA-6803529 8.170655e-01 0.088 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.170655e-01 0.088 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.170655e-01 0.088 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.195883e-01 0.086 0 0
Degradation of DVL R-HSA-4641258 8.218705e-01 0.085 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.218705e-01 0.085 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.218705e-01 0.085 0 0
Translesion synthesis by POLI R-HSA-5656121 8.229761e-01 0.085 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.229761e-01 0.085 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.229761e-01 0.085 0 0
Regulation of BACH1 activity R-HSA-9708530 8.229761e-01 0.085 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.229761e-01 0.085 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.229761e-01 0.085 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 8.229761e-01 0.085 0 0
Activation of SMO R-HSA-5635838 8.229761e-01 0.085 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.235354e-01 0.084 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 8.237185e-01 0.084 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 8.237185e-01 0.084 0 0
MET receptor recycling R-HSA-8875656 8.237185e-01 0.084 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 8.237185e-01 0.084 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 8.237185e-01 0.084 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.237185e-01 0.084 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 8.237185e-01 0.084 0 0
TGFBR3 PTM regulation R-HSA-9839383 8.237185e-01 0.084 0 0
Nucleotide salvage defects R-HSA-9734207 8.237185e-01 0.084 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 8.237185e-01 0.084 0 0
Alpha-defensins R-HSA-1462054 8.237185e-01 0.084 0 0
Sodium/Proton exchangers R-HSA-425986 8.237185e-01 0.084 0 0
Adaptive Immune System R-HSA-1280218 8.264812e-01 0.083 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.270309e-01 0.082 0 0
Extension of Telomeres R-HSA-180786 8.272331e-01 0.082 0 0
Orc1 removal from chromatin R-HSA-68949 8.327876e-01 0.079 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.338835e-01 0.079 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.338835e-01 0.079 0 0
Budding and maturation of HIV virion R-HSA-162588 8.338835e-01 0.079 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.348588e-01 0.078 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.348588e-01 0.078 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.348588e-01 0.078 0 0
Interleukin-20 family signaling R-HSA-8854691 8.348588e-01 0.078 0 0
GABA receptor activation R-HSA-977443 8.387742e-01 0.076 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.387742e-01 0.076 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.399986e-01 0.076 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.399986e-01 0.076 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.399986e-01 0.076 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.399986e-01 0.076 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.399986e-01 0.076 0 0
G alpha (s) signalling events R-HSA-418555 8.429745e-01 0.074 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.430903e-01 0.074 0 0
Phase 2 - plateau phase R-HSA-5576893 8.430903e-01 0.074 0 0
Translesion synthesis by POLK R-HSA-5655862 8.430903e-01 0.074 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.430903e-01 0.074 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.430903e-01 0.074 0 0
Passive transport by Aquaporins R-HSA-432047 8.430903e-01 0.074 0 0
Synthesis of PG R-HSA-1483148 8.430903e-01 0.074 0 0
Response to metal ions R-HSA-5660526 8.430903e-01 0.074 0 0
Circadian clock R-HSA-9909396 8.436764e-01 0.074 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.485686e-01 0.071 0 0
Phospholipid metabolism R-HSA-1483257 8.489480e-01 0.071 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.494591e-01 0.071 0 0
Interleukin-21 signaling R-HSA-9020958 8.494591e-01 0.071 0 0
MAPK1 (ERK2) activation R-HSA-112411 8.494591e-01 0.071 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.494591e-01 0.071 0 0
Degradation of GABA R-HSA-916853 8.494591e-01 0.071 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 8.494591e-01 0.071 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.494591e-01 0.071 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.494704e-01 0.071 0 0
Stabilization of p53 R-HSA-69541 8.494704e-01 0.071 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.494704e-01 0.071 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.494704e-01 0.071 0 0
Signaling by NOTCH1 R-HSA-1980143 8.507340e-01 0.070 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.511334e-01 0.070 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.511396e-01 0.070 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.511396e-01 0.070 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.511396e-01 0.070 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.511396e-01 0.070 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.511396e-01 0.070 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.511396e-01 0.070 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.521680e-01 0.069 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.540882e-01 0.068 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.558346e-01 0.068 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.611065e-01 0.065 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.611065e-01 0.065 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.618828e-01 0.065 0 0
Glycogen metabolism R-HSA-8982491 8.618828e-01 0.065 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.618828e-01 0.065 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.618828e-01 0.065 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.621398e-01 0.064 0 0
GPCR downstream signalling R-HSA-388396 8.627664e-01 0.064 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.635684e-01 0.064 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.635684e-01 0.064 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.660021e-01 0.062 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.660021e-01 0.062 0 0
G protein gated Potassium channels R-HSA-1296059 8.660021e-01 0.062 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.660021e-01 0.062 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.660021e-01 0.062 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.680444e-01 0.061 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.697662e-01 0.061 0 0
IRE1alpha activates chaperones R-HSA-381070 8.703430e-01 0.060 0 0
2-LTR circle formation R-HSA-164843 8.714423e-01 0.060 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.714423e-01 0.060 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.714423e-01 0.060 0 0
Josephin domain DUBs R-HSA-5689877 8.714423e-01 0.060 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.714423e-01 0.060 0 0
Interleukin-27 signaling R-HSA-9020956 8.714423e-01 0.060 0 0
Maturation of spike protein R-HSA-9683686 8.714423e-01 0.060 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.714423e-01 0.060 0 0
Sperm Motility And Taxes R-HSA-1300642 8.714423e-01 0.060 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.714423e-01 0.060 0 0
Peptide hormone biosynthesis R-HSA-209952 8.714423e-01 0.060 0 0
Serotonin receptors R-HSA-390666 8.714423e-01 0.060 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.734241e-01 0.059 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.734241e-01 0.059 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.734241e-01 0.059 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.734241e-01 0.059 0 0
Maturation of spike protein R-HSA-9694548 8.734241e-01 0.059 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.734241e-01 0.059 0 0
Intraflagellar transport R-HSA-5620924 8.742302e-01 0.058 0 0
Metal ion SLC transporters R-HSA-425410 8.742302e-01 0.058 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.746559e-01 0.058 0 0
Heme degradation R-HSA-189483 8.746559e-01 0.058 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.746559e-01 0.058 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.772083e-01 0.057 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.772083e-01 0.057 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.772083e-01 0.057 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 8.772083e-01 0.057 0 0
Signaling by Insulin receptor R-HSA-74752 8.781357e-01 0.056 0 0
rRNA processing R-HSA-72312 8.789430e-01 0.056 0 0
Myogenesis R-HSA-525793 8.795405e-01 0.056 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.795405e-01 0.056 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.795405e-01 0.056 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.795405e-01 0.056 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.795405e-01 0.056 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.795405e-01 0.056 0 0
Selenoamino acid metabolism R-HSA-2408522 8.807977e-01 0.055 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.841363e-01 0.053 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.854879e-01 0.053 0 0
Adipogenesis R-HSA-9843745 8.857513e-01 0.053 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.861768e-01 0.052 0 0
Signal amplification R-HSA-392518 8.861768e-01 0.052 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.861768e-01 0.052 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.902165e-01 0.051 0 0
vRNP Assembly R-HSA-192905 8.902165e-01 0.051 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.902165e-01 0.051 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.902165e-01 0.051 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.902165e-01 0.051 0 0
Prostanoid ligand receptors R-HSA-391908 8.902165e-01 0.051 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.910310e-01 0.050 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.915706e-01 0.050 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.915706e-01 0.050 0 0
Maturation of nucleoprotein R-HSA-9694631 8.915706e-01 0.050 0 0
Packaging Of Telomere Ends R-HSA-171306 8.918479e-01 0.050 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.918479e-01 0.050 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.918479e-01 0.050 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.918479e-01 0.050 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.918479e-01 0.050 0 0
Synthesis of DNA R-HSA-69239 8.934629e-01 0.049 0 0
Activation of GABAB receptors R-HSA-991365 8.940620e-01 0.049 0 0
GABA B receptor activation R-HSA-977444 8.940620e-01 0.049 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.940620e-01 0.049 0 0
Depyrimidination R-HSA-73928 8.940620e-01 0.049 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.967621e-01 0.047 0 0
Regulation of Apoptosis R-HSA-169911 8.967621e-01 0.047 0 0
Platelet degranulation R-HSA-114608 8.991167e-01 0.046 0 0
Meiotic recombination R-HSA-912446 9.021030e-01 0.045 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.022864e-01 0.045 0 0
Defective pyroptosis R-HSA-9710421 9.032439e-01 0.044 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.043580e-01 0.044 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.043580e-01 0.044 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.043580e-01 0.044 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.043580e-01 0.044 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.049538e-01 0.043 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.049538e-01 0.043 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.056503e-01 0.043 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 9.062498e-01 0.043 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 9.062498e-01 0.043 0 0
Plasmalogen biosynthesis R-HSA-75896 9.062498e-01 0.043 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 9.062498e-01 0.043 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 9.062498e-01 0.043 0 0
Integration of provirus R-HSA-162592 9.062498e-01 0.043 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 9.062498e-01 0.043 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.064708e-01 0.043 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.064708e-01 0.043 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.065700e-01 0.043 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.098639e-01 0.041 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.098639e-01 0.041 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.098639e-01 0.041 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.098639e-01 0.041 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.098639e-01 0.041 0 0
UCH proteinases R-HSA-5689603 9.116931e-01 0.040 0 0
Proteasome assembly R-HSA-9907900 9.117243e-01 0.040 0 0
DNA methylation R-HSA-5334118 9.131288e-01 0.039 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.131288e-01 0.039 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.133136e-01 0.039 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.153605e-01 0.038 0 0
Degradation of AXIN R-HSA-4641257 9.153605e-01 0.038 0 0
Cleavage of the damaged purine R-HSA-110331 9.153605e-01 0.038 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.157240e-01 0.038 0 0
Lagging Strand Synthesis R-HSA-69186 9.157240e-01 0.038 0 0
Signalling to RAS R-HSA-167044 9.157240e-01 0.038 0 0
Phenylalanine metabolism R-HSA-8964208 9.157240e-01 0.038 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.157240e-01 0.038 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.175825e-01 0.037 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.179187e-01 0.037 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.195449e-01 0.036 0 0
Nucleosome assembly R-HSA-774815 9.195449e-01 0.036 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.195449e-01 0.036 0 0
Interleukin-35 Signalling R-HSA-8984722 9.199423e-01 0.036 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.199423e-01 0.036 0 0
Estrogen biosynthesis R-HSA-193144 9.199423e-01 0.036 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.222737e-01 0.035 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.222737e-01 0.035 0 0
Hemostasis R-HSA-109582 9.227364e-01 0.035 0 0
G alpha (q) signalling events R-HSA-416476 9.234136e-01 0.035 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.234874e-01 0.035 0 0
Depurination R-HSA-73927 9.234874e-01 0.035 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.244885e-01 0.034 0 0
Nucleotide Excision Repair R-HSA-5696398 9.245778e-01 0.034 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.258110e-01 0.033 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.258110e-01 0.033 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.258110e-01 0.033 0 0
Assembly Of The HIV Virion R-HSA-175474 9.258110e-01 0.033 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.267464e-01 0.033 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.292695e-01 0.032 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.305290e-01 0.031 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.305290e-01 0.031 0 0
Cargo concentration in the ER R-HSA-5694530 9.305290e-01 0.031 0 0
G alpha (z) signalling events R-HSA-418597 9.308807e-01 0.031 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.309055e-01 0.031 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.316357e-01 0.031 0 0
Processing of SMDT1 R-HSA-8949664 9.316357e-01 0.031 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 9.316357e-01 0.031 0 0
Chylomicron remodeling R-HSA-8963901 9.316357e-01 0.031 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.316357e-01 0.031 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.316357e-01 0.031 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.316357e-01 0.031 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.316357e-01 0.031 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.316357e-01 0.031 0 0
Parasitic Infection Pathways R-HSA-9824443 9.322222e-01 0.030 0 0
Leishmania infection R-HSA-9658195 9.322222e-01 0.030 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 9.347211e-01 0.029 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.347327e-01 0.029 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.347501e-01 0.029 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.347501e-01 0.029 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.347501e-01 0.029 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.347501e-01 0.029 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.347501e-01 0.029 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.367897e-01 0.028 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.369452e-01 0.028 0 0
Signaling by NOTCH R-HSA-157118 9.374799e-01 0.028 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.376669e-01 0.028 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.376669e-01 0.028 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.379702e-01 0.028 0 0
Cellular response to hypoxia R-HSA-1234174 9.406086e-01 0.027 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.412753e-01 0.026 0 0
Transport of fatty acids R-HSA-804914 9.416217e-01 0.026 0 0
Hydrolysis of LPC R-HSA-1483115 9.416217e-01 0.026 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.416217e-01 0.026 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.416217e-01 0.026 0 0
Malate-aspartate shuttle R-HSA-9856872 9.416217e-01 0.026 0 0
Ciprofloxacin ADME R-HSA-9793528 9.416217e-01 0.026 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.416217e-01 0.026 0 0
P2Y receptors R-HSA-417957 9.416217e-01 0.026 0 0
Zinc transporters R-HSA-435354 9.416217e-01 0.026 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.416217e-01 0.026 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.426613e-01 0.026 0 0
Formation of the ureteric bud R-HSA-9830674 9.426613e-01 0.026 0 0
Carnitine shuttle R-HSA-200425 9.426613e-01 0.026 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.438210e-01 0.025 0 0
ER-Phagosome pathway R-HSA-1236974 9.442186e-01 0.025 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.446679e-01 0.025 0 0
Co-inhibition by PD-1 R-HSA-389948 9.446702e-01 0.025 0 0
DNA Damage Bypass R-HSA-73893 9.450271e-01 0.025 0 0
Dual incision in TC-NER R-HSA-6782135 9.472758e-01 0.024 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.472758e-01 0.024 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.483978e-01 0.023 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.489290e-01 0.023 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.494150e-01 0.023 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.494150e-01 0.023 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.496542e-01 0.022 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.501495e-01 0.022 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.501495e-01 0.022 0 0
Signaling by Activin R-HSA-1502540 9.501495e-01 0.022 0 0
Protein repair R-HSA-5676934 9.501495e-01 0.022 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.501495e-01 0.022 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.506881e-01 0.022 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.506881e-01 0.022 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.506881e-01 0.022 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.521224e-01 0.021 0 0
Inositol phosphate metabolism R-HSA-1483249 9.531081e-01 0.021 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.544932e-01 0.020 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.548088e-01 0.020 0 0
The phototransduction cascade R-HSA-2514856 9.548088e-01 0.020 0 0
Dual Incision in GG-NER R-HSA-5696400 9.560925e-01 0.020 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.560925e-01 0.020 0 0
eNOS activation R-HSA-203615 9.560925e-01 0.020 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.560925e-01 0.020 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.560925e-01 0.020 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.560925e-01 0.020 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.564658e-01 0.019 0 0
Interferon Signaling R-HSA-913531 9.571940e-01 0.019 0 0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 9.574320e-01 0.019 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.574320e-01 0.019 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.574320e-01 0.019 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.574320e-01 0.019 0 0
Killing mechanisms R-HSA-9664420 9.574320e-01 0.019 0 0
Attachment and Entry R-HSA-9678110 9.574320e-01 0.019 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.574320e-01 0.019 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.574320e-01 0.019 0 0
Fructose catabolism R-HSA-70350 9.574320e-01 0.019 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.574320e-01 0.019 0 0
Atorvastatin ADME R-HSA-9754706 9.574320e-01 0.019 0 0
Developmental Cell Lineages R-HSA-9734767 9.584997e-01 0.018 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.590791e-01 0.018 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.590975e-01 0.018 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.600896e-01 0.018 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.600896e-01 0.018 0 0
PERK regulates gene expression R-HSA-381042 9.609380e-01 0.017 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.609380e-01 0.017 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.609380e-01 0.017 0 0
Abacavir ADME R-HSA-2161522 9.612731e-01 0.017 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.612731e-01 0.017 0 0
Chromosome Maintenance R-HSA-73886 9.624569e-01 0.017 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.636510e-01 0.016 0 0
Coenzyme A biosynthesis R-HSA-196783 9.636510e-01 0.016 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.636510e-01 0.016 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.636510e-01 0.016 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.636510e-01 0.016 0 0
Mitochondrial protein import R-HSA-1268020 9.636858e-01 0.016 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.646320e-01 0.016 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.649745e-01 0.015 0 0
Mitochondrial protein degradation R-HSA-9837999 9.650187e-01 0.015 0 0
Collagen formation R-HSA-1474290 9.650187e-01 0.015 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.652773e-01 0.015 0 0
RNA Polymerase III Transcription R-HSA-74158 9.652773e-01 0.015 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.660704e-01 0.015 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.670390e-01 0.015 0 0
Somitogenesis R-HSA-9824272 9.670390e-01 0.015 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.689617e-01 0.014 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.689617e-01 0.014 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.689617e-01 0.014 0 0
Glycogen storage diseases R-HSA-3229121 9.689617e-01 0.014 0 0
Catecholamine biosynthesis R-HSA-209905 9.689617e-01 0.014 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.689617e-01 0.014 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.689617e-01 0.014 0 0
Choline catabolism R-HSA-6798163 9.689617e-01 0.014 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.689617e-01 0.014 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.691590e-01 0.014 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.691590e-01 0.014 0 0
Interferon gamma signaling R-HSA-877300 9.696867e-01 0.013 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.701971e-01 0.013 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.702929e-01 0.013 0 0
Pyrimidine salvage R-HSA-73614 9.702929e-01 0.013 0 0
Immune System R-HSA-168256 9.715868e-01 0.013 0 0
Peptide hormone metabolism R-HSA-2980736 9.717072e-01 0.012 0 0
Elastic fibre formation R-HSA-1566948 9.726277e-01 0.012 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.727105e-01 0.012 0 0
Neurotransmitter release cycle R-HSA-112310 9.732769e-01 0.012 0 0
Base Excision Repair R-HSA-73884 9.732769e-01 0.012 0 0
Signaling by NOTCH4 R-HSA-9013694 9.733756e-01 0.012 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.734968e-01 0.012 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.734968e-01 0.012 0 0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 9.734968e-01 0.012 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.734968e-01 0.012 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.734968e-01 0.012 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.734968e-01 0.012 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.734968e-01 0.012 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.734968e-01 0.012 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.734968e-01 0.012 0 0
Synthesis of PC R-HSA-1483191 9.735234e-01 0.012 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.740061e-01 0.011 0 0
Telomere Maintenance R-HSA-157579 9.747073e-01 0.011 0 0
Signaling by GPCR R-HSA-372790 9.749938e-01 0.011 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.757241e-01 0.011 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.772687e-01 0.010 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.773694e-01 0.010 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.784854e-01 0.009 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.784854e-01 0.009 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.784854e-01 0.009 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.793485e-01 0.009 0 0
Translation of Structural Proteins R-HSA-9694635 9.798884e-01 0.009 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.801331e-01 0.009 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.801331e-01 0.009 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.803784e-01 0.009 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.806764e-01 0.008 0 0
Glycogen synthesis R-HSA-3322077 9.806764e-01 0.008 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.806764e-01 0.008 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.806764e-01 0.008 0 0
Pregnenolone biosynthesis R-HSA-196108 9.806764e-01 0.008 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.809457e-01 0.008 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.810723e-01 0.008 0 0
PCP/CE pathway R-HSA-4086400 9.817083e-01 0.008 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.820180e-01 0.008 0 0
DNA strand elongation R-HSA-69190 9.826460e-01 0.008 0 0
Translation of Structural Proteins R-HSA-9683701 9.831358e-01 0.007 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.833870e-01 0.007 0 0
COPII-mediated vesicle transport R-HSA-204005 9.833870e-01 0.007 0 0
G-protein activation R-HSA-202040 9.835003e-01 0.007 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.835003e-01 0.007 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.835003e-01 0.007 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.836535e-01 0.007 0 0
Collagen degradation R-HSA-1442490 9.838269e-01 0.007 0 0
DNA Replication R-HSA-69306 9.842137e-01 0.007 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.848489e-01 0.007 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.848831e-01 0.007 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.850837e-01 0.007 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.854635e-01 0.006 0 0
tRNA processing in the nucleus R-HSA-6784531 9.854635e-01 0.006 0 0
Attachment and Entry R-HSA-9694614 9.859117e-01 0.006 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.859117e-01 0.006 0 0
Serine metabolism R-HSA-977347 9.859117e-01 0.006 0 0
Glutathione synthesis and recycling R-HSA-174403 9.859117e-01 0.006 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.865135e-01 0.006 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.867787e-01 0.006 0 0
Fructose metabolism R-HSA-5652084 9.879707e-01 0.005 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.883518e-01 0.005 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.884682e-01 0.005 0 0
Gap junction assembly R-HSA-190861 9.884682e-01 0.005 0 0
Signaling by NOTCH2 R-HSA-1980145 9.884682e-01 0.005 0 0
Paracetamol ADME R-HSA-9753281 9.892859e-01 0.005 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.897290e-01 0.004 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.897290e-01 0.004 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.897290e-01 0.004 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.897290e-01 0.004 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.897290e-01 0.004 0 0
Protein ubiquitination R-HSA-8852135 9.900288e-01 0.004 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.900288e-01 0.004 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.904590e-01 0.004 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.906227e-01 0.004 0 0
Protein folding R-HSA-391251 9.906836e-01 0.004 0 0
ABC-family proteins mediated transport R-HSA-382556 9.907722e-01 0.004 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.907758e-01 0.004 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.912303e-01 0.004 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.912303e-01 0.004 0 0
Interferon alpha/beta signaling R-HSA-909733 9.912453e-01 0.004 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.923685e-01 0.003 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.923685e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.923685e-01 0.003 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.925122e-01 0.003 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.925122e-01 0.003 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.925122e-01 0.003 0 0
Fertilization R-HSA-1187000 9.925122e-01 0.003 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.925122e-01 0.003 0 0
Laminin interactions R-HSA-3000157 9.925122e-01 0.003 0 0
Interleukin-10 signaling R-HSA-6783783 9.927120e-01 0.003 0 0
Leishmania phagocytosis R-HSA-9664417 9.929153e-01 0.003 0 0
Parasite infection R-HSA-9664407 9.929153e-01 0.003 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.929153e-01 0.003 0 0
Peroxisomal protein import R-HSA-9033241 9.932857e-01 0.003 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.934424e-01 0.003 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.934724e-01 0.003 0 0
MET activates PTK2 signaling R-HSA-8874081 9.936069e-01 0.003 0 0
Urea cycle R-HSA-70635 9.936069e-01 0.003 0 0
Sphingolipid catabolism R-HSA-9845614 9.936069e-01 0.003 0 0
Gap junction trafficking and regulation R-HSA-157858 9.937841e-01 0.003 0 0
RSV-host interactions R-HSA-9833110 9.942140e-01 0.003 0 0
Pentose phosphate pathway R-HSA-71336 9.942165e-01 0.003 0 0
RAS processing R-HSA-9648002 9.942165e-01 0.003 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.942541e-01 0.003 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.945415e-01 0.002 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.945415e-01 0.002 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.945415e-01 0.002 0 0
Triglyceride biosynthesis R-HSA-75109 9.945415e-01 0.002 0 0
Synthesis of PE R-HSA-1483213 9.945415e-01 0.002 0 0
Signaling by BMP R-HSA-201451 9.945415e-01 0.002 0 0
Amyloid fiber formation R-HSA-977225 9.946997e-01 0.002 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.949681e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.949681e-01 0.002 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.949681e-01 0.002 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.951822e-01 0.002 0 0
Prednisone ADME R-HSA-9757110 9.953396e-01 0.002 0 0
Protein localization R-HSA-9609507 9.955007e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.956235e-01 0.002 0 0
Gene Silencing by RNA R-HSA-211000 9.956538e-01 0.002 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.957615e-01 0.002 0 0
Thyroxine biosynthesis R-HSA-209968 9.960210e-01 0.002 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.960210e-01 0.002 0 0
Iron uptake and transport R-HSA-917937 9.965583e-01 0.001 0 0
Neurotransmitter clearance R-HSA-112311 9.966028e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.966929e-01 0.001 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.969308e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.970961e-01 0.001 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.970996e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.974287e-01 0.001 0 0
Gap junction trafficking R-HSA-190828 9.975042e-01 0.001 0 0
RNA Polymerase I Transcription R-HSA-73864 9.975626e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.975626e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.977243e-01 0.001 0 0
Recycling of bile acids and salts R-HSA-159418 9.978859e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.981188e-01 0.001 0 0
Viral Infection Pathways R-HSA-9824446 9.981662e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.982916e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.983674e-01 0.001 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.983674e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.983753e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.984263e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.984263e-01 0.001 0 0
RA biosynthesis pathway R-HSA-5365859 9.984591e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.984591e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.985020e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.985020e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.985020e-01 0.001 0 0
Gluconeogenesis R-HSA-70263 9.985836e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.986095e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.986845e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.986845e-01 0.001 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.986845e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.986845e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.986869e-01 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.987715e-01 0.001 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.987877e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.988769e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.989158e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.989347e-01 0.000 0 0
HCMV Early Events R-HSA-9609690 9.990178e-01 0.000 0 0
NCAM1 interactions R-HSA-419037 9.990412e-01 0.000 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.990412e-01 0.000 0 0
Lysine catabolism R-HSA-71064 9.990412e-01 0.000 0 0
Neddylation R-HSA-8951664 9.990527e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.990765e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.991223e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.991545e-01 0.000 0 0
Purine salvage R-HSA-74217 9.991815e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.991821e-01 0.000 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.993012e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.993065e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.993216e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.993437e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.993781e-01 0.000 0 0
Tryptophan catabolism R-HSA-71240 9.994035e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.994086e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.994574e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.995653e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.995653e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.996048e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.996099e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.996099e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.996547e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.996547e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.996631e-01 0.000 0 0
Defensins R-HSA-1461973 9.996832e-01 0.000 0 0
Methylation R-HSA-156581 9.997296e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.997296e-01 0.000 0 0
Surfactant metabolism R-HSA-5683826 9.997296e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.997691e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998035e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.998173e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.998365e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.998564e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.998667e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.998688e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.998688e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.998838e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.998912e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.998954e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999002e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999087e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999117e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.999164e-01 0.000 0 0
HCMV Infection R-HSA-9609646 9.999170e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999211e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999436e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999475e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.999492e-01 0.000 0 0
Digestion R-HSA-8935690 9.999595e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999621e-01 0.000 0 0
HCMV Late Events R-HSA-9610379 9.999644e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.999668e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999748e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999785e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999790e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999797e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999817e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999819e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999843e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999866e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999870e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999886e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999886e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999900e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999903e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999928e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999929e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999942e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999946e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999952e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999953e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999956e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999963e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999968e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999973e-01 0.000 0 0
Translation R-HSA-72766 9.999973e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999973e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999977e-01 0.000 0 0
tRNA processing R-HSA-72306 9.999979e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999986e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999990e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999993e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999995e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999998e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999998e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999998e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999998e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999998e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999999e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 1.000000e+00 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Nervous system development R-HSA-9675108 1.442180e-13 12.841 0 0
Axon guidance R-HSA-422475 2.279288e-13 12.642 0 0
Cell Cycle R-HSA-1640170 3.529399e-13 12.452 0 0
M Phase R-HSA-68886 3.949285e-12 11.403 0 0
Signal Transduction R-HSA-162582 3.722356e-12 11.429 0 0
Cell Cycle, Mitotic R-HSA-69278 2.256428e-11 10.647 0 0
Cellular responses to stimuli R-HSA-8953897 5.874368e-11 10.231 0 0
Mitotic Prometaphase R-HSA-68877 2.351453e-10 9.629 0 0
Apoptotic execution phase R-HSA-75153 2.678288e-10 9.572 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.387462e-10 9.269 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.550732e-09 8.593 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.072537e-09 8.513 0 0
Cellular responses to stress R-HSA-2262752 4.892513e-09 8.310 0 0
Cell Cycle Checkpoints R-HSA-69620 1.428012e-08 7.845 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.990639e-08 7.701 0 0
Post NMDA receptor activation events R-HSA-438064 2.156453e-08 7.666 1 0
Signaling by VEGF R-HSA-194138 3.705649e-08 7.431 0 0
Cell-Cell communication R-HSA-1500931 4.595597e-08 7.338 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 8.019813e-08 7.096 0 0
Mitotic Anaphase R-HSA-68882 7.734087e-08 7.112 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.084070e-08 7.092 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 9.014844e-08 7.045 0 0
Metabolism of RNA R-HSA-8953854 1.071251e-07 6.970 0 0
Recycling pathway of L1 R-HSA-437239 2.941522e-07 6.531 0 0
FLT3 Signaling R-HSA-9607240 3.123004e-07 6.505 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.144149e-07 6.383 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.472221e-07 6.349 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.784322e-07 6.320 1 0
Separation of Sister Chromatids R-HSA-2467813 5.814534e-07 6.235 0 0
Signaling by RAS mutants R-HSA-6802949 7.127429e-07 6.147 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.127429e-07 6.147 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.127429e-07 6.147 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.127429e-07 6.147 0 0
EPH-Ephrin signaling R-HSA-2682334 7.198678e-07 6.143 0 0
Apoptosis R-HSA-109581 9.069045e-07 6.042 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.452146e-07 6.024 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.046733e-06 5.980 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.149433e-06 5.940 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.550493e-06 5.810 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.682454e-06 5.774 0 0
Chromatin organization R-HSA-4839726 1.922870e-06 5.716 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.988462e-06 5.701 0 0
Chromatin modifying enzymes R-HSA-3247509 1.972931e-06 5.705 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.330086e-06 5.633 0 0
Programmed Cell Death R-HSA-5357801 2.267717e-06 5.644 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.435684e-06 5.613 0 0
Membrane Trafficking R-HSA-199991 2.505422e-06 5.601 0 0
Aggrephagy R-HSA-9646399 2.701182e-06 5.568 0 0
ESR-mediated signaling R-HSA-8939211 2.894669e-06 5.538 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.152915e-06 5.501 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.487450e-06 5.457 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.711686e-06 5.430 0 0
Cellular Senescence R-HSA-2559583 3.771422e-06 5.423 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.359183e-06 5.361 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.888084e-06 5.311 0 0
Cell junction organization R-HSA-446728 5.221167e-06 5.282 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.606157e-06 5.251 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.022143e-06 5.220 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.348912e-06 5.197 0 0
mRNA Splicing R-HSA-72172 7.551610e-06 5.122 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.399264e-06 5.076 0 0
G2/M Checkpoints R-HSA-69481 8.904754e-06 5.050 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.467365e-06 5.024 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.467365e-06 5.024 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.036598e-05 4.984 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.136708e-05 4.944 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.241650e-05 4.906 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.297869e-05 4.887 0 0
Cellular response to heat stress R-HSA-3371556 1.329158e-05 4.876 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.925960e-05 4.715 0 0
Translation initiation complex formation R-HSA-72649 2.180183e-05 4.662 0 0
PKR-mediated signaling R-HSA-9833482 2.402602e-05 4.619 0 0
Selective autophagy R-HSA-9663891 2.451648e-05 4.611 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.496863e-05 4.603 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.723509e-05 4.565 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.688350e-05 4.571 0 0
L1CAM interactions R-HSA-373760 2.761630e-05 4.559 0 0
G2/M Transition R-HSA-69275 3.236376e-05 4.490 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.671467e-05 4.435 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.565225e-05 4.448 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.789215e-05 4.421 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.937247e-05 4.405 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.785834e-05 4.320 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.000774e-05 4.301 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.696277e-05 4.244 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.696277e-05 4.244 0 0
Interleukin-12 signaling R-HSA-9020591 6.406126e-05 4.193 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.066730e-05 4.151 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.632638e-05 4.117 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.262347e-05 4.083 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.904642e-05 4.050 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.560311e-05 4.068 0 0
Signaling by ERBB2 R-HSA-1227986 8.904642e-05 4.050 0 0
Signaling by SCF-KIT R-HSA-1433557 8.523236e-05 4.069 0 0
Kinesins R-HSA-983189 8.904642e-05 4.050 0 0
Mitotic Prophase R-HSA-68875 1.081072e-04 3.966 0 0
MAPK family signaling cascades R-HSA-5683057 1.123635e-04 3.949 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.173995e-04 3.930 0 0
Signaling by Hippo R-HSA-2028269 1.199154e-04 3.921 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.136273e-04 3.945 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.207348e-04 3.918 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.230352e-04 3.910 0 0
Centrosome maturation R-HSA-380287 1.261755e-04 3.899 0 0
Meiotic synapsis R-HSA-1221632 1.269825e-04 3.896 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.363707e-04 3.865 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.367296e-04 3.864 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.363707e-04 3.865 0 0
MAP2K and MAPK activation R-HSA-5674135 1.455132e-04 3.837 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.483735e-04 3.829 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.512551e-04 3.820 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.512551e-04 3.820 0 0
DNA Double Strand Break Response R-HSA-5693606 1.530664e-04 3.815 0 0
Ephrin signaling R-HSA-3928664 1.795056e-04 3.746 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.911980e-04 3.719 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.129864e-04 3.672 0 0
Autophagy R-HSA-9612973 2.072534e-04 3.683 0 0
Adherens junctions interactions R-HSA-418990 2.302316e-04 3.638 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.445275e-04 3.612 0 0
Interleukin-12 family signaling R-HSA-447115 2.458612e-04 3.609 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.502405e-04 3.602 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.502405e-04 3.602 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.553911e-04 3.593 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.556133e-04 3.592 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.860020e-04 3.544 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.273169e-04 3.485 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.292655e-04 3.482 0 0
Macroautophagy R-HSA-1632852 3.608475e-04 3.443 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.683115e-04 3.434 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.729374e-04 3.428 0 0
Cell-cell junction organization R-HSA-421270 4.053070e-04 3.392 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.305767e-04 3.366 0 0
Signaling by ALK in cancer R-HSA-9700206 4.305767e-04 3.366 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.362844e-04 3.360 0 0
RAF activation R-HSA-5673000 4.366114e-04 3.360 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.736687e-04 3.325 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.672424e-04 3.330 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.675187e-04 3.330 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.928140e-04 3.307 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.944563e-04 3.306 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.089313e-04 3.293 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.180260e-04 3.286 0 0
Cilium Assembly R-HSA-5617833 5.486015e-04 3.261 0 0
Death Receptor Signaling R-HSA-73887 5.542118e-04 3.256 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.635714e-04 3.249 0 0
Deubiquitination R-HSA-5688426 5.797173e-04 3.237 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.845556e-04 3.233 0 0
Signaling by EGFR R-HSA-177929 6.002483e-04 3.222 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.430323e-04 3.192 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.430323e-04 3.192 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.678229e-04 3.175 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.795590e-04 3.168 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.812896e-04 3.167 0 0
Signaling by ROBO receptors R-HSA-376176 6.842398e-04 3.165 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.135717e-04 3.147 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.320300e-04 3.135 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.320300e-04 3.135 1 1
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.713534e-04 3.113 0 0
Gap junction trafficking R-HSA-190828 7.888749e-04 3.103 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.016950e-04 3.096 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.057402e-04 3.094 0 0
Smooth Muscle Contraction R-HSA-445355 8.057402e-04 3.094 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.232672e-04 3.084 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.232672e-04 3.084 0 0
Gap junction trafficking and regulation R-HSA-157858 8.882945e-04 3.051 0 0
Signaling by PTK6 R-HSA-8848021 9.388906e-04 3.027 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.388906e-04 3.027 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.588146e-04 3.018 0 0
Striated Muscle Contraction R-HSA-390522 9.605222e-04 3.017 0 0
Nucleosome assembly R-HSA-774815 9.737224e-04 3.012 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.737224e-04 3.012 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 9.737224e-04 3.012 0 0
DAP12 signaling R-HSA-2424491 9.965827e-04 3.001 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.000412e-03 3.000 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.017393e-03 2.993 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.098958e-03 2.959 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.100119e-03 2.959 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.126315e-03 2.948 0 0
PECAM1 interactions R-HSA-210990 1.170584e-03 2.932 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.224676e-03 2.912 0 0
Homology Directed Repair R-HSA-5693538 1.224676e-03 2.912 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.286724e-03 2.891 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.167110e-03 2.933 0 0
Gap junction assembly R-HSA-190861 1.220374e-03 2.914 0 0
Protein folding R-HSA-391251 1.291676e-03 2.889 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.292681e-03 2.889 0 0
HSF1-dependent transactivation R-HSA-3371571 1.312046e-03 2.882 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.325016e-03 2.878 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.378239e-03 2.861 0 0
Meiosis R-HSA-1500620 1.469741e-03 2.833 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.665966e-03 2.778 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.665966e-03 2.778 0 0
Regulation of CDH1 Function R-HSA-9764561 1.686680e-03 2.773 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.686680e-03 2.773 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.763668e-03 2.754 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.794634e-03 2.746 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.992383e-03 2.701 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.067655e-03 2.685 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.924008e-03 2.716 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.082426e-03 2.681 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.898992e-03 2.721 0 0
Semaphorin interactions R-HSA-373755 2.089786e-03 2.680 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.944970e-03 2.711 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.960575e-03 2.708 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.888969e-03 2.724 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.122385e-03 2.673 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.122385e-03 2.673 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.186934e-03 2.660 0 0
MHC class II antigen presentation R-HSA-2132295 2.202714e-03 2.657 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.214104e-03 2.655 0 0
Nef and signal transduction R-HSA-164944 2.226650e-03 2.652 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.226650e-03 2.652 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.243722e-03 2.649 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.288614e-03 2.640 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.293161e-03 2.640 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.293161e-03 2.640 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.333286e-03 2.632 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.333286e-03 2.632 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.433023e-03 2.614 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.478780e-03 2.606 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.548420e-03 2.594 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.937357e-03 2.532 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.937357e-03 2.532 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.937357e-03 2.532 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.937357e-03 2.532 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.937357e-03 2.532 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.937357e-03 2.532 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.937357e-03 2.532 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.937357e-03 2.532 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.937357e-03 2.532 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.937357e-03 2.532 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.937357e-03 2.532 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.655778e-03 2.576 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.655778e-03 2.576 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.784828e-03 2.555 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.803995e-03 2.552 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.924084e-03 2.534 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.803995e-03 2.552 0 0
Signaling by WNT R-HSA-195721 2.874445e-03 2.541 0 0
Interferon Signaling R-HSA-913531 2.594037e-03 2.586 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.794039e-03 2.554 0 0
Signaling by Interleukins R-HSA-449147 2.852301e-03 2.545 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.952669e-03 2.530 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.969876e-03 2.527 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.010459e-03 2.521 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.010459e-03 2.521 0 0
Regulation of TP53 Activity R-HSA-5633007 3.134408e-03 2.504 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.204137e-03 2.494 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.211579e-03 2.493 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.211579e-03 2.493 0 0
Nuclear import of Rev protein R-HSA-180746 3.211579e-03 2.493 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.226219e-03 2.491 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.569278e-03 2.447 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.606504e-03 2.443 0 0
HATs acetylate histones R-HSA-3214847 3.650422e-03 2.438 0 0
SOS-mediated signalling R-HSA-112412 3.715195e-03 2.430 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.715195e-03 2.430 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.829686e-03 2.417 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.829686e-03 2.417 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.810049e-03 2.419 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.755520e-03 2.425 0 0
Packaging Of Telomere Ends R-HSA-171306 3.755520e-03 2.425 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.326645e-03 2.364 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.301194e-03 2.366 0 0
HCMV Early Events R-HSA-9609690 4.343951e-03 2.362 0 0
Co-stimulation by CD28 R-HSA-389356 4.087025e-03 2.389 0 0
Signalling to ERKs R-HSA-187687 3.952900e-03 2.403 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.967272e-03 2.402 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.737686e-03 2.427 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.810049e-03 2.419 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.810049e-03 2.419 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.344570e-03 2.362 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.501824e-03 2.347 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.621079e-03 2.335 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.796437e-03 2.319 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.827591e-03 2.316 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.827591e-03 2.316 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.892157e-03 2.310 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.071659e-03 2.295 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.071659e-03 2.295 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.335261e-03 2.273 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.335261e-03 2.273 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.353698e-03 2.271 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.353698e-03 2.271 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.585647e-03 2.253 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.830037e-03 2.234 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.838394e-03 2.234 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.838394e-03 2.234 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.852244e-03 2.233 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.888964e-03 2.230 0 0
DNA methylation R-HSA-5334118 5.888964e-03 2.230 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.951850e-03 2.225 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.405975e-03 2.193 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.513622e-03 2.186 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.542156e-03 2.184 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.643366e-03 2.178 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.814368e-03 2.167 0 0
NRAGE signals death through JNK R-HSA-193648 6.814658e-03 2.167 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.859568e-03 2.164 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.882392e-03 2.162 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.882392e-03 2.162 0 0
Erythropoietin activates RAS R-HSA-9027284 7.243638e-03 2.140 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 7.243638e-03 2.140 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 7.243638e-03 2.140 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.266621e-03 2.139 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.266621e-03 2.139 0 0
Vesicle-mediated transport R-HSA-5653656 7.384946e-03 2.132 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.885575e-03 2.051 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.885575e-03 2.051 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.667768e-03 2.115 0 0
mRNA 3'-end processing R-HSA-72187 7.825312e-03 2.106 0 0
Myogenesis R-HSA-525793 8.000855e-03 2.097 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.734858e-03 2.112 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.734858e-03 2.112 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.042864e-03 2.095 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.776441e-03 2.109 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.931085e-03 2.101 0 0
Signaling by NTRKs R-HSA-166520 7.851701e-03 2.105 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.422177e-03 2.075 0 0
Host Interactions of HIV factors R-HSA-162909 7.538981e-03 2.123 0 0
Developmental Biology R-HSA-1266738 7.405226e-03 2.130 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.911532e-03 2.102 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.931085e-03 2.101 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 8.987451e-03 2.046 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.534361e-03 2.021 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.542462e-03 2.020 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.542462e-03 2.020 0 0
MET activates RAS signaling R-HSA-8851805 9.575638e-03 2.019 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 9.575638e-03 2.019 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.888069e-03 2.005 0 0
Attenuation phase R-HSA-3371568 1.000470e-02 2.000 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.000470e-02 2.000 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.031136e-02 1.987 1 0
snRNP Assembly R-HSA-191859 1.049468e-02 1.979 0 0
Metabolism of non-coding RNA R-HSA-194441 1.049468e-02 1.979 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.065688e-02 1.972 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.077244e-02 1.968 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.104596e-02 1.957 0 0
Protein ubiquitination R-HSA-8852135 1.134226e-02 1.945 0 0
FLT3 signaling in disease R-HSA-9682385 1.139893e-02 1.943 0 0
GPVI-mediated activation cascade R-HSA-114604 1.139893e-02 1.943 0 0
Negative regulation of MET activity R-HSA-6807004 1.184965e-02 1.926 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.184965e-02 1.926 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.184965e-02 1.926 0 0
Nephrin family interactions R-HSA-373753 1.184965e-02 1.926 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.187466e-02 1.925 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.203515e-02 1.920 0 0
HDACs deacetylate histones R-HSA-3214815 1.212949e-02 1.916 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.221636e-02 1.913 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.223272e-02 1.912 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.241558e-02 1.906 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.253248e-02 1.902 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.253248e-02 1.902 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.261212e-02 1.899 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.284782e-02 1.891 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.295442e-02 1.888 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.295442e-02 1.888 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.295442e-02 1.888 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.296731e-02 1.887 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.349564e-02 1.870 0 0
Cleavage of the damaged purine R-HSA-110331 1.352359e-02 1.869 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.401668e-02 1.853 0 0
Meiotic recombination R-HSA-912446 1.402513e-02 1.853 0 0
Co-inhibition by PD-1 R-HSA-389948 1.405983e-02 1.852 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.408532e-02 1.851 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.607371e-02 1.794 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.607371e-02 1.794 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.736351e-02 1.760 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.714552e-02 1.766 0 0
Long-term potentiation R-HSA-9620244 1.652909e-02 1.782 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.467004e-02 1.834 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.545899e-02 1.811 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.501568e-02 1.823 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.763061e-02 1.754 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.652909e-02 1.782 0 0
G alpha (12/13) signalling events R-HSA-416482 1.611048e-02 1.793 0 0
MTOR signalling R-HSA-165159 1.617731e-02 1.791 0 0
Peptide chain elongation R-HSA-156902 1.662790e-02 1.779 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.545899e-02 1.811 0 0
RNA Polymerase I Transcription R-HSA-73864 1.611048e-02 1.793 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.543503e-02 1.811 0 0
Muscle contraction R-HSA-397014 1.540781e-02 1.812 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.763061e-02 1.754 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.686841e-02 1.773 0 0
Cellular response to chemical stress R-HSA-9711123 1.827518e-02 1.738 0 0
Regulation of KIT signaling R-HSA-1433559 1.714552e-02 1.766 0 0
HDMs demethylate histones R-HSA-3214842 1.652909e-02 1.782 0 0
Depurination R-HSA-73927 1.593980e-02 1.798 0 0
Diseases of programmed cell death R-HSA-9645723 1.662790e-02 1.779 0 0
Activation of BH3-only proteins R-HSA-114452 1.763061e-02 1.754 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.545899e-02 1.811 0 0
Influenza Infection R-HSA-168255 1.643166e-02 1.784 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.848589e-02 1.733 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.867096e-02 1.729 0 0
Intraflagellar transport R-HSA-5620924 1.868978e-02 1.728 0 0
Defective pyroptosis R-HSA-9710421 1.877680e-02 1.726 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.967744e-02 1.706 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.967744e-02 1.706 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.967744e-02 1.706 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.003971e-02 1.698 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.003971e-02 1.698 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.044099e-02 1.689 0 0
Tie2 Signaling R-HSA-210993 2.044099e-02 1.689 0 0
Ribosome-associated quality control R-HSA-9948299 2.058255e-02 1.687 0 0
Signaling by RAS GAP mutants R-HSA-9753510 2.098395e-02 1.678 0 0
Downstream signal transduction R-HSA-186763 2.101428e-02 1.677 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.103856e-02 1.677 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.154556e-02 1.667 0 0
DAP12 interactions R-HSA-2172127 2.168082e-02 1.664 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.174027e-02 1.663 0 0
Generation of second messenger molecules R-HSA-202433 2.174027e-02 1.663 0 0
p75NTR signals via NF-kB R-HSA-193639 2.219287e-02 1.654 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.219287e-02 1.654 0 0
TCR signaling R-HSA-202403 2.221818e-02 1.653 0 0
Hedgehog 'off' state R-HSA-5610787 2.249875e-02 1.648 0 0
Glycolysis R-HSA-70171 2.249875e-02 1.648 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.266381e-02 1.645 0 0
Signaling by KIT in disease R-HSA-9669938 2.266381e-02 1.645 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.306759e-02 1.637 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.306759e-02 1.637 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.306759e-02 1.637 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.329587e-02 1.633 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.333975e-02 1.632 0 0
NF-kB is activated and signals survival R-HSA-209560 2.333975e-02 1.632 0 0
Eukaryotic Translation Termination R-HSA-72764 2.365954e-02 1.626 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.406589e-02 1.619 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.446432e-02 1.611 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.517047e-02 1.599 0 0
Regulation of signaling by CBL R-HSA-912631 2.543322e-02 1.595 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.543322e-02 1.595 0 0
The NLRP3 inflammasome R-HSA-844456 2.543322e-02 1.595 0 0
Chromosome Maintenance R-HSA-73886 2.573218e-02 1.590 0 0
rRNA processing R-HSA-72312 2.576142e-02 1.589 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.614244e-02 1.583 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.617672e-02 1.582 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.701549e-02 1.568 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.705211e-02 1.568 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.792516e-02 1.554 0 0
Prolonged ERK activation events R-HSA-169893 2.818421e-02 1.550 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.838112e-02 1.547 0 0
Integrin signaling R-HSA-354192 2.917575e-02 1.535 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.917575e-02 1.535 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.924638e-02 1.534 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.001160e-02 1.523 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.004551e-02 1.522 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.004551e-02 1.522 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.004551e-02 1.522 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.004551e-02 1.522 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.055901e-02 1.515 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.177584e-02 1.498 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.177584e-02 1.498 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.177584e-02 1.498 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.177584e-02 1.498 0 0
Interleukin-1 processing R-HSA-448706 3.177584e-02 1.498 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.451684e-02 1.462 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.451684e-02 1.462 0 0
CREB phosphorylation R-HSA-199920 4.310443e-02 1.365 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.229551e-02 1.374 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.229551e-02 1.374 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.518480e-02 1.454 0 0
Signaling by Erythropoietin R-HSA-9006335 3.380855e-02 1.471 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.241530e-02 1.489 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.549041e-02 1.450 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.796506e-02 1.421 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.987363e-02 1.399 0 0
Signaling by MET R-HSA-6806834 3.505654e-02 1.455 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.066849e-02 1.391 0 0
IGF1R signaling cascade R-HSA-2428924 3.658946e-02 1.437 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.282601e-02 1.368 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.380855e-02 1.471 0 0
Signalling to RAS R-HSA-167044 3.784398e-02 1.422 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.380855e-02 1.471 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.281693e-02 1.484 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.241530e-02 1.489 0 0
Adaptive Immune System R-HSA-1280218 3.989640e-02 1.399 0 0
DNA Repair R-HSA-73894 3.525601e-02 1.453 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.876057e-02 1.412 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.307218e-02 1.481 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.310443e-02 1.365 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.229551e-02 1.374 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.910023e-02 1.408 0 0
Reproduction R-HSA-1474165 3.860710e-02 1.413 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.320094e-02 1.479 0 0
Depyrimidination R-HSA-73928 3.320094e-02 1.479 0 0
Gene Silencing by RNA R-HSA-211000 4.465906e-02 1.350 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.535161e-02 1.343 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.535161e-02 1.343 0 0
EGFR downregulation R-HSA-182971 4.601698e-02 1.337 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.620569e-02 1.335 0 0
MAP kinase activation R-HSA-450294 4.737185e-02 1.324 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.847067e-02 1.315 0 0
DAG and IP3 signaling R-HSA-1489509 4.847067e-02 1.315 0 0
Signal regulatory protein family interactions R-HSA-391160 4.902157e-02 1.310 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.902157e-02 1.310 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.972929e-02 1.303 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.026255e-02 1.299 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.026255e-02 1.299 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.026255e-02 1.299 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.026255e-02 1.299 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.126560e-02 1.290 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 5.155385e-02 1.288 0 0
RET signaling R-HSA-8853659 5.185249e-02 1.285 0 0
HSF1 activation R-HSA-3371511 5.185249e-02 1.285 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.241756e-02 1.281 0 0
G0 and Early G1 R-HSA-1538133 5.311250e-02 1.275 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.385093e-02 1.269 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.448987e-02 1.264 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.485544e-02 1.261 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.531507e-02 1.257 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.750717e-02 1.240 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.750717e-02 1.240 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.750717e-02 1.240 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.750717e-02 1.240 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.750717e-02 1.240 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.750717e-02 1.240 0 0
Immune System R-HSA-168256 5.783474e-02 1.238 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 5.810293e-02 1.236 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.867685e-02 1.232 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.888161e-02 1.230 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.035934e-02 1.219 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.035934e-02 1.219 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.035934e-02 1.219 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.035934e-02 1.219 0 0
DCC mediated attractive signaling R-HSA-418885 6.035934e-02 1.219 0 0
Protein methylation R-HSA-8876725 6.035934e-02 1.219 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.035934e-02 1.219 0 0
p38MAPK events R-HSA-171007 6.035934e-02 1.219 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.411640e-02 1.193 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.603482e-02 1.180 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.641905e-02 1.178 0 0
Gene expression (Transcription) R-HSA-74160 6.708936e-02 1.173 0 0
Neutrophil degranulation R-HSA-6798695 6.742087e-02 1.171 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.756300e-02 1.170 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.894975e-02 1.161 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.029801e-02 1.153 0 0
Manipulation of host energy metabolism R-HSA-9636667 7.074454e-02 1.150 0 0
TRAF3 deficiency - HSE R-HSA-5602571 7.074454e-02 1.150 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.074454e-02 1.150 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.144097e-02 1.146 0 0
Signaling by FGFR4 R-HSA-5654743 7.154015e-02 1.145 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.171286e-02 1.144 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 7.216492e-02 1.142 0 0
Telomere Maintenance R-HSA-157579 7.281581e-02 1.138 0 0
Negative regulation of FLT3 R-HSA-9706369 7.312780e-02 1.136 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.345149e-02 1.134 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.410121e-02 1.130 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.417088e-02 1.130 0 0
Signaling by NOTCH R-HSA-157118 7.466544e-02 1.127 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.552079e-02 1.122 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.552079e-02 1.122 0 0
Degradation of CDH1 R-HSA-9766229 7.552079e-02 1.122 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.731800e-02 1.112 0 0
Type I hemidesmosome assembly R-HSA-446107 7.731800e-02 1.112 0 0
Activation of RAS in B cells R-HSA-1169092 7.731800e-02 1.112 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.147040e-01 0.940 0 0
IRS activation R-HSA-74713 8.239825e-02 1.084 0 0
G2 Phase R-HSA-68911 8.239825e-02 1.084 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.110820e-01 0.954 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 1.110820e-01 0.954 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.110820e-01 0.954 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 9.828197e-02 1.008 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 9.828197e-02 1.008 1 1
ARMS-mediated activation R-HSA-170984 9.828197e-02 1.008 0 0
Lipophagy R-HSA-9613354 9.828197e-02 1.008 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 9.828197e-02 1.008 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 9.828197e-02 1.008 0 0
ALK mutants bind TKIs R-HSA-9700645 9.828197e-02 1.008 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.507444e-02 1.070 0 0
Repression of WNT target genes R-HSA-4641265 8.507444e-02 1.070 0 0
Disorders of Nervous System Development R-HSA-9697154 8.507444e-02 1.070 0 0
Pervasive developmental disorders R-HSA-9005895 8.507444e-02 1.070 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.507444e-02 1.070 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.029966e-01 0.987 0 0
Disorders of Developmental Biology R-HSA-9675151 8.731950e-02 1.059 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.731950e-02 1.059 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.029064e-01 0.988 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.187120e-02 1.087 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.072777e-01 0.969 0 0
Viral mRNA Translation R-HSA-192823 1.101299e-01 0.958 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.072777e-01 0.969 0 0
Cyclin D associated events in G1 R-HSA-69231 7.975339e-02 1.098 0 0
G1 Phase R-HSA-69236 7.975339e-02 1.098 0 0
FOXO-mediated transcription R-HSA-9614085 8.413847e-02 1.075 0 0
PLC beta mediated events R-HSA-112043 8.151180e-02 1.089 0 0
Ca-dependent events R-HSA-111996 1.149508e-01 0.939 0 0
CaM pathway R-HSA-111997 9.914438e-02 1.004 0 0
Calmodulin induced events R-HSA-111933 9.914438e-02 1.004 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.731950e-02 1.059 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.696245e-02 1.013 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.024435e-01 0.990 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.853841e-02 1.053 0 0
Frs2-mediated activation R-HSA-170968 1.029966e-01 0.987 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.172625e-01 0.931 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 9.369294e-02 1.028 0 0
Signaling by PDGF R-HSA-186797 8.915192e-02 1.050 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.029064e-01 0.988 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.696245e-02 1.013 0 0
Interleukin-17 signaling R-HSA-448424 1.072777e-01 0.969 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.999008e-02 1.097 0 0
Neurexins and neuroligins R-HSA-6794361 1.011743e-01 0.995 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.187120e-02 1.087 0 0
Regulation of IFNG signaling R-HSA-877312 8.507444e-02 1.070 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 8.731950e-02 1.059 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.914438e-02 1.004 0 0
Signaling by FGFR3 R-HSA-5654741 8.853841e-02 1.053 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.285296e-02 1.032 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.814731e-02 1.055 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 9.374844e-02 1.028 0 0
Signaling by LTK R-HSA-9842663 8.507444e-02 1.070 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.176019e-01 0.930 0 0
HCMV Infection R-HSA-9609646 8.851307e-02 1.053 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.176019e-01 0.930 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.176019e-01 0.930 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.507444e-02 1.070 0 0
HIV Infection R-HSA-162906 9.683032e-02 1.014 0 0
Cardiogenesis R-HSA-9733709 1.172625e-01 0.931 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 9.828197e-02 1.008 0 0
Interleukin-1 family signaling R-HSA-446652 1.166555e-01 0.933 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.040327e-01 0.983 0 0
Ub-specific processing proteases R-HSA-5689880 1.015101e-01 0.993 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.101423e-01 0.958 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.147040e-01 0.940 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.147040e-01 0.940 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 9.828197e-02 1.008 0 0
Netrin-1 signaling R-HSA-373752 7.975339e-02 1.098 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.172625e-01 0.931 0 0
tRNA processing in the nucleus R-HSA-6784531 8.915192e-02 1.050 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.172625e-01 0.931 0 0
Glucose metabolism R-HSA-70326 1.027981e-01 0.988 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.029966e-01 0.987 0 0
Selenocysteine synthesis R-HSA-2408557 9.657129e-02 1.015 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.731950e-02 1.059 0 0
Interleukin-37 signaling R-HSA-9008059 8.187120e-02 1.087 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.198413e-01 0.921 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.198413e-01 0.921 0 0
Signal attenuation R-HSA-74749 1.215841e-01 0.915 0 0
2-LTR circle formation R-HSA-164843 1.215841e-01 0.915 0 0
Josephin domain DUBs R-HSA-5689877 1.215841e-01 0.915 0 0
Regulation of CDH11 function R-HSA-9762292 1.215841e-01 0.915 0 0
PI3K/AKT activation R-HSA-198203 1.215841e-01 0.915 0 0
Signaling by Leptin R-HSA-2586552 1.215841e-01 0.915 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.226257e-01 0.911 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.226257e-01 0.911 0 0
Inflammasomes R-HSA-622312 1.242469e-01 0.906 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.250089e-01 0.903 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.256672e-01 0.901 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.258290e-01 0.900 0 0
TBC/RABGAPs R-HSA-8854214 1.264946e-01 0.898 0 0
S Phase R-HSA-69242 1.304142e-01 0.885 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.306620e-01 0.884 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.312903e-01 0.882 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.329601e-01 0.876 0 0
G-protein mediated events R-HSA-112040 1.339221e-01 0.873 0 0
Base Excision Repair R-HSA-73884 1.343869e-01 0.872 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.345552e-01 0.871 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.345552e-01 0.871 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.345552e-01 0.871 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.345552e-01 0.871 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.345552e-01 0.871 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.345552e-01 0.871 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.345552e-01 0.871 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.345552e-01 0.871 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.345552e-01 0.871 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.345552e-01 0.871 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.345552e-01 0.871 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.345552e-01 0.871 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.345552e-01 0.871 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.345552e-01 0.871 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.345552e-01 0.871 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.345552e-01 0.871 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.345552e-01 0.871 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.345552e-01 0.871 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.345552e-01 0.871 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.345552e-01 0.871 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.345552e-01 0.871 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.345552e-01 0.871 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.345552e-01 0.871 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.345552e-01 0.871 0 0
Sensory processing of sound R-HSA-9659379 1.347026e-01 0.871 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.380599e-01 0.860 0 0
RMTs methylate histone arginines R-HSA-3214858 1.386520e-01 0.858 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.392471e-01 0.856 0 0
Platelet calcium homeostasis R-HSA-418360 1.392471e-01 0.856 0 0
Inositol phosphate metabolism R-HSA-1483249 1.395445e-01 0.855 0 0
Signaling by Hedgehog R-HSA-5358351 1.401883e-01 0.853 0 0
Ion homeostasis R-HSA-5578775 1.426155e-01 0.846 0 0
TNF signaling R-HSA-75893 1.426155e-01 0.846 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.429726e-01 0.845 0 0
STAT5 Activation R-HSA-9645135 1.429726e-01 0.845 0 0
Neurofascin interactions R-HSA-447043 1.429726e-01 0.845 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.436279e-01 0.843 0 0
RNA Polymerase II Transcription R-HSA-73857 1.463459e-01 0.835 0 0
Interleukin-2 signaling R-HSA-9020558 1.469914e-01 0.833 0 0
Deadenylation of mRNA R-HSA-429947 1.482468e-01 0.829 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.482468e-01 0.829 0 0
Neurodegenerative Diseases R-HSA-8863678 1.482468e-01 0.829 0 0
Interleukin-2 family signaling R-HSA-451927 1.487310e-01 0.828 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.547471e-01 0.810 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.559751e-01 0.807 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.575480e-01 0.803 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 1.597342e-01 0.797 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 1.597342e-01 0.797 0 0
TRKA activation by NGF R-HSA-187042 1.636603e-01 0.786 0 0
Axonal growth stimulation R-HSA-209563 1.636603e-01 0.786 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.636603e-01 0.786 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.636603e-01 0.786 0 0
MET interacts with TNS proteins R-HSA-8875513 1.636603e-01 0.786 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.636603e-01 0.786 0 0
MET activates PTPN11 R-HSA-8865999 1.636603e-01 0.786 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 1.636603e-01 0.786 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.636603e-01 0.786 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.647417e-01 0.783 0 0
UCH proteinases R-HSA-5689603 1.652300e-01 0.782 0 0
DNA Replication R-HSA-69306 1.655190e-01 0.781 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.658461e-01 0.780 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.659165e-01 0.780 0 0
Insulin receptor signalling cascade R-HSA-74751 1.663065e-01 0.779 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.664115e-01 0.779 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.665164e-01 0.779 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.665164e-01 0.779 0 0
Opioid Signalling R-HSA-111885 1.682552e-01 0.774 0 0
G1/S Transition R-HSA-69206 1.689829e-01 0.772 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.726542e-01 0.763 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.733641e-01 0.761 0 0
Activation of RAC1 R-HSA-428540 1.742408e-01 0.759 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.742408e-01 0.759 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.742408e-01 0.759 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.742408e-01 0.759 0 0
Integration of provirus R-HSA-162592 1.742408e-01 0.759 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.510121e-01 0.600 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.510121e-01 0.600 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.510121e-01 0.600 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.510121e-01 0.600 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.510121e-01 0.600 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.510121e-01 0.600 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.510121e-01 0.600 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.510121e-01 0.600 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.510121e-01 0.600 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.510121e-01 0.600 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.510121e-01 0.600 0 0
TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3642279 2.510121e-01 0.600 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.154742e-01 0.667 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 2.154742e-01 0.667 0 0
NADE modulates death signalling R-HSA-205025 2.154742e-01 0.667 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.154742e-01 0.667 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.154742e-01 0.667 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.154742e-01 0.667 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.154742e-01 0.667 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.518040e-01 0.454 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.518040e-01 0.454 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 3.518040e-01 0.454 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.518040e-01 0.454 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.518040e-01 0.454 0 0
Defective APRT disrupts adenine salvage R-HSA-9734195 3.518040e-01 0.454 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.518040e-01 0.454 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.518040e-01 0.454 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.518040e-01 0.454 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.518040e-01 0.454 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.518040e-01 0.454 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.518040e-01 0.454 0 0
Activation of TRKA receptors R-HSA-187015 1.774544e-01 0.751 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.774544e-01 0.751 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.774544e-01 0.751 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.684912e-01 0.571 0 0
NrCAM interactions R-HSA-447038 2.684912e-01 0.571 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.684912e-01 0.571 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.684912e-01 0.571 0 0
NTRK2 activates RAC1 R-HSA-9032759 2.684912e-01 0.571 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.684912e-01 0.571 0 0
Interleukin-18 signaling R-HSA-9012546 2.139160e-01 0.670 0 0
Formation of annular gap junctions R-HSA-196025 2.139160e-01 0.670 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.030509e-01 0.692 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.030509e-01 0.692 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.030509e-01 0.692 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.030509e-01 0.692 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.030509e-01 0.692 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.030509e-01 0.692 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.030509e-01 0.692 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.517745e-01 0.599 0 0
WNT mediated activation of DVL R-HSA-201688 2.517745e-01 0.599 0 0
Gap junction degradation R-HSA-190873 2.517745e-01 0.599 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.214500e-01 0.493 0 0
NGF-independant TRKA activation R-HSA-187024 3.214500e-01 0.493 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.214500e-01 0.493 0 0
Phosphorylation of Emi1 R-HSA-176417 3.214500e-01 0.493 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.214500e-01 0.493 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.214500e-01 0.493 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.904855e-01 0.720 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.904855e-01 0.720 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.904855e-01 0.720 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.904855e-01 0.720 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 1.780167e-01 0.750 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.780167e-01 0.750 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.780167e-01 0.750 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.904909e-01 0.537 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.904909e-01 0.537 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 1.995598e-01 0.700 0 0
Notch-HLH transcription pathway R-HSA-350054 2.220006e-01 0.654 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.295788e-01 0.482 0 0
Signaling by APC mutants R-HSA-4839744 3.295788e-01 0.482 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.295788e-01 0.482 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.295788e-01 0.482 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.295788e-01 0.482 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.959602e-01 0.529 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.959602e-01 0.529 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.959602e-01 0.529 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.959602e-01 0.529 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.959602e-01 0.529 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.684852e-01 0.571 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.452222e-01 0.610 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.261646e-01 0.646 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 2.691042e-01 0.570 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 3.281574e-01 0.484 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.281574e-01 0.484 0 0
Phosphorylation of the APC/C R-HSA-176412 3.281574e-01 0.484 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.790295e-01 0.747 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.259836e-01 0.646 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.238075e-01 0.490 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.068232e-01 0.684 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.899579e-01 0.538 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.213843e-01 0.655 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.519493e-01 0.454 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.554429e-01 0.593 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.767104e-01 0.558 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 3.434930e-01 0.464 0 0
Cristae formation R-HSA-8949613 3.434930e-01 0.464 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.005663e-01 0.522 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.488224e-01 0.457 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.892470e-01 0.723 0 0
G-protein beta:gamma signalling R-HSA-397795 2.073674e-01 0.683 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.416450e-01 0.617 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.191174e-01 0.659 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.353468e-01 0.475 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.922961e-01 0.716 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.183607e-01 0.497 0 0
Nucleotide Excision Repair R-HSA-5696398 2.555661e-01 0.592 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.030509e-01 0.692 0 0
Signaling by Insulin receptor R-HSA-74752 3.107405e-01 0.508 0 0
p75NTR regulates axonogenesis R-HSA-193697 2.517745e-01 0.599 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.416450e-01 0.617 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.281574e-01 0.484 0 0
TGFBR3 expression R-HSA-9839394 2.935244e-01 0.532 0 0
DNA strand elongation R-HSA-69190 3.124992e-01 0.505 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.046671e-01 0.689 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.249639e-01 0.648 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 1.916178e-01 0.718 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.899579e-01 0.538 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.781207e-01 0.556 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 3.275535e-01 0.485 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 2.139160e-01 0.670 0 0
Metalloprotease DUBs R-HSA-5689901 3.183607e-01 0.497 0 0
GAB1 signalosome R-HSA-180292 2.416450e-01 0.617 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.211509e-01 0.655 0 0
Ca2+ pathway R-HSA-4086398 2.014740e-01 0.696 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.406351e-01 0.619 0 0
Muscarinic acetylcholine receptors R-HSA-390648 2.684912e-01 0.571 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.439778e-01 0.613 0 0
Regulation of Apoptosis R-HSA-169911 2.654462e-01 0.576 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.392062e-01 0.621 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.211509e-01 0.655 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.524465e-01 0.598 0 0
Signaling by FGFR2 R-HSA-5654738 2.959349e-01 0.529 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.995598e-01 0.700 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 1.995598e-01 0.700 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 2.220006e-01 0.654 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.455465e-01 0.610 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 2.935244e-01 0.532 0 0
IRS-mediated signalling R-HSA-112399 2.363520e-01 0.626 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.524465e-01 0.598 0 0
Formation of definitive endoderm R-HSA-9823730 2.959304e-01 0.529 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.154742e-01 0.667 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.684912e-01 0.571 0 0
Reelin signalling pathway R-HSA-8866376 2.684912e-01 0.571 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.139160e-01 0.670 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.030509e-01 0.692 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.452222e-01 0.610 0 0
Signaling by WNT in cancer R-HSA-4791275 3.124992e-01 0.505 0 0
Signal transduction by L1 R-HSA-445144 2.959304e-01 0.529 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.129992e-01 0.504 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.232361e-01 0.490 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.232361e-01 0.490 0 0
Degradation of DVL R-HSA-4641258 3.065206e-01 0.514 0 0
Translation R-HSA-72766 3.254114e-01 0.488 0 0
PTEN Regulation R-HSA-6807070 2.588267e-01 0.587 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.439778e-01 0.613 0 0
Signaling by FGFR1 R-HSA-5654736 2.213843e-01 0.655 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.005663e-01 0.522 0 0
HIV Life Cycle R-HSA-162587 1.970418e-01 0.705 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.774933e-01 0.751 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 1.904855e-01 0.720 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.916178e-01 0.718 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.461575e-01 0.609 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.073674e-01 0.683 0 0
Circadian clock R-HSA-9909396 3.131468e-01 0.504 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.684912e-01 0.571 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.214500e-01 0.493 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.044441e-01 0.689 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.058125e-01 0.687 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.354823e-01 0.628 0 0
Transmission across Chemical Synapses R-HSA-112315 2.808189e-01 0.552 1 0
Platelet homeostasis R-HSA-418346 3.494450e-01 0.457 0 0
Cellular response to starvation R-HSA-9711097 2.637355e-01 0.579 0 0
Generic Transcription Pathway R-HSA-212436 2.815782e-01 0.550 0 0
Signaling by TGFBR3 R-HSA-9839373 2.590574e-01 0.587 0 0
Platelet sensitization by LDL R-HSA-432142 2.416450e-01 0.617 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.333228e-01 0.632 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.046671e-01 0.689 0 0
Stabilization of p53 R-HSA-69541 3.488224e-01 0.457 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.073674e-01 0.683 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.782821e-01 0.749 0 0
Inhibition of PKR R-HSA-169131 2.510121e-01 0.600 0 0
MTF1 activates gene expression R-HSA-5660489 2.154742e-01 0.667 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.518040e-01 0.454 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.518040e-01 0.454 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.684912e-01 0.571 0 0
Unwinding of DNA R-HSA-176974 2.517745e-01 0.599 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.214500e-01 0.493 0 0
mTORC1-mediated signalling R-HSA-166208 2.220006e-01 0.654 0 0
Bicarbonate transporters R-HSA-425381 3.295788e-01 0.482 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.455465e-01 0.610 0 0
Trafficking of AMPA receptors R-HSA-399719 2.899579e-01 0.538 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.052919e-01 0.688 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.780167e-01 0.750 0 0
Rab regulation of trafficking R-HSA-9007101 2.013423e-01 0.696 0 0
Formation of paraxial mesoderm R-HSA-9793380 2.996793e-01 0.523 0 0
NCAM signaling for neurite out-growth R-HSA-375165 2.191174e-01 0.659 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 2.590574e-01 0.587 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 2.590574e-01 0.587 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.833932e-01 0.548 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.790295e-01 0.747 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.275535e-01 0.485 0 0
Hemostasis R-HSA-109582 2.451430e-01 0.611 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.904909e-01 0.537 0 0
Amyloid fiber formation R-HSA-977225 3.104531e-01 0.508 0 0
Somitogenesis R-HSA-9824272 2.417937e-01 0.617 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.498797e-01 0.456 0 0
RUNX2 regulates bone development R-HSA-8941326 2.857944e-01 0.544 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.554429e-01 0.593 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.275535e-01 0.485 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.157565e-01 0.501 0 0
Signaling by ERBB4 R-HSA-1236394 2.140549e-01 0.669 0 0
Mitochondrial biogenesis R-HSA-1592230 2.684171e-01 0.571 0 0
Growth hormone receptor signaling R-HSA-982772 2.452222e-01 0.610 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.675580e-01 0.573 0 0
Signaling by NOTCH4 R-HSA-9013694 3.023839e-01 0.519 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.204701e-01 0.657 0 0
Inhibition of membrane repair R-HSA-9635644 3.518040e-01 0.454 0 0
PTK6 Activates STAT3 R-HSA-8849474 2.684912e-01 0.571 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.214500e-01 0.493 0 0
TRAIL signaling R-HSA-75158 3.214500e-01 0.493 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.295788e-01 0.482 0 0
Signaling by FGFR3 in disease R-HSA-5655332 3.434930e-01 0.464 0 0
Viral Infection Pathways R-HSA-9824446 2.421803e-01 0.616 0 0
Basigin interactions R-HSA-210991 3.238075e-01 0.490 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.211509e-01 0.655 0 0
CASP4 inflammasome assembly R-HSA-9948001 2.904909e-01 0.537 0 0
Signaling by ALK R-HSA-201556 2.259836e-01 0.646 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.654462e-01 0.576 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 1.774544e-01 0.751 0 0
Co-inhibition by BTLA R-HSA-9927353 2.684912e-01 0.571 0 0
Non-canonical inflammasome activation R-HSA-9686114 2.641957e-01 0.578 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.353468e-01 0.475 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.774544e-01 0.751 0 0
SARS-CoV Infections R-HSA-9679506 3.123317e-01 0.505 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.295788e-01 0.482 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.574126e-01 0.447 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.574126e-01 0.447 0 0
Interleukin-1 signaling R-HSA-9020702 3.577384e-01 0.446 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.584109e-01 0.446 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.584109e-01 0.446 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.605361e-01 0.443 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.605361e-01 0.443 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.686095e-01 0.433 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.686095e-01 0.433 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.686095e-01 0.433 0 0
Signaling by AXIN mutants R-HSA-4839735 3.686095e-01 0.433 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 3.688045e-01 0.433 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.688045e-01 0.433 0 0
Orc1 removal from chromatin R-HSA-68949 3.691776e-01 0.433 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.702569e-01 0.431 0 0
Diseases of Immune System R-HSA-5260271 3.702569e-01 0.431 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.702569e-01 0.431 0 0
Parasitic Infection Pathways R-HSA-9824443 3.711546e-01 0.430 0 0
Leishmania infection R-HSA-9658195 3.711546e-01 0.430 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.734068e-01 0.428 0 0
Signaling by LTK in cancer R-HSA-9842640 3.734068e-01 0.428 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.734068e-01 0.428 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.734068e-01 0.428 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 3.734068e-01 0.428 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 3.734068e-01 0.428 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.734068e-01 0.428 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.737915e-01 0.427 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.756632e-01 0.425 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.756632e-01 0.425 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.756632e-01 0.425 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.771586e-01 0.423 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.799005e-01 0.420 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.799849e-01 0.420 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.801965e-01 0.420 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.816042e-01 0.418 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 3.816042e-01 0.418 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.816042e-01 0.418 0 0
eNOS activation R-HSA-203615 3.816042e-01 0.418 0 0
Mitophagy R-HSA-5205647 3.816042e-01 0.418 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.881785e-01 0.411 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.902622e-01 0.409 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.917884e-01 0.407 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.928651e-01 0.406 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.928651e-01 0.406 0 0
Specification of primordial germ cells R-HSA-9827857 3.928651e-01 0.406 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.928651e-01 0.406 0 0
Late endosomal microautophagy R-HSA-9615710 3.941830e-01 0.404 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.006942e-01 0.397 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.048420e-01 0.393 0 0
Neuronal System R-HSA-112316 4.052674e-01 0.392 1 0
Toll-like Receptor Cascades R-HSA-168898 4.055324e-01 0.392 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.072126e-01 0.390 0 0
Polymerase switching R-HSA-69091 4.072126e-01 0.390 0 0
Leading Strand Synthesis R-HSA-69109 4.072126e-01 0.390 0 0
Interleukin-15 signaling R-HSA-8983432 4.072126e-01 0.390 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.072126e-01 0.390 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 4.072126e-01 0.390 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.072386e-01 0.390 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.116508e-01 0.385 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.133501e-01 0.384 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.133501e-01 0.384 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.195216e-01 0.377 0 0
Activation of the pre-replicative complex R-HSA-68962 4.195216e-01 0.377 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.195216e-01 0.377 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.195216e-01 0.377 0 0
GPER1 signaling R-HSA-9634597 4.203712e-01 0.376 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.203712e-01 0.376 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.236726e-01 0.373 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.236726e-01 0.373 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 4.236726e-01 0.373 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.236726e-01 0.373 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.236726e-01 0.373 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 4.236726e-01 0.373 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 4.236726e-01 0.373 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.236726e-01 0.373 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.236726e-01 0.373 0 0
CHL1 interactions R-HSA-447041 4.236726e-01 0.373 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.236726e-01 0.373 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 4.236726e-01 0.373 0 0
PKA activation R-HSA-163615 4.249352e-01 0.372 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.249352e-01 0.372 0 0
Signaling by NOTCH3 R-HSA-9012852 4.263125e-01 0.370 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.280431e-01 0.369 0 0
RNA Polymerase III Transcription R-HSA-74158 4.280431e-01 0.369 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.280431e-01 0.369 0 0
FCERI mediated MAPK activation R-HSA-2871796 4.301346e-01 0.366 0 0
Heme signaling R-HSA-9707616 4.314394e-01 0.365 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.348777e-01 0.362 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.390372e-01 0.357 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 4.390372e-01 0.357 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 4.390372e-01 0.357 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 4.390372e-01 0.357 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.390372e-01 0.357 0 0
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735 4.390372e-01 0.357 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.390372e-01 0.357 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.390372e-01 0.357 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.390372e-01 0.357 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 4.390372e-01 0.357 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.390372e-01 0.357 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.390372e-01 0.357 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 4.390372e-01 0.357 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.390372e-01 0.357 0 0
Diseases of Cellular Senescence R-HSA-9630747 4.390372e-01 0.357 0 0
Diseases of cellular response to stress R-HSA-9675132 4.390372e-01 0.357 0 0
Signaling by NOTCH1 R-HSA-1980143 4.399240e-01 0.357 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.437120e-01 0.353 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.447200e-01 0.352 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.450751e-01 0.352 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.450751e-01 0.352 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.450751e-01 0.352 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.450751e-01 0.352 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 4.450751e-01 0.352 0 0
Formation of axial mesoderm R-HSA-9796292 4.450751e-01 0.352 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 4.450751e-01 0.352 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.450751e-01 0.352 0 0
Maturation of nucleoprotein R-HSA-9683610 4.450751e-01 0.352 0 0
Interleukin-6 signaling R-HSA-1059683 4.450751e-01 0.352 0 0
Degradation of AXIN R-HSA-4641257 4.511306e-01 0.346 0 0
Integration of energy metabolism R-HSA-163685 4.529551e-01 0.344 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.549406e-01 0.342 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.565600e-01 0.341 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.565600e-01 0.341 0 0
Rap1 signalling R-HSA-392517 4.565600e-01 0.341 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.565600e-01 0.341 0 0
Downstream TCR signaling R-HSA-202424 4.620827e-01 0.335 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.641316e-01 0.333 0 0
Tight junction interactions R-HSA-420029 4.641316e-01 0.333 0 0
Interleukin-7 signaling R-HSA-1266695 4.641316e-01 0.333 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.696848e-01 0.328 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.696848e-01 0.328 0 0
Selenoamino acid metabolism R-HSA-2408522 4.716364e-01 0.326 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.717617e-01 0.326 0 0
Regulation by c-FLIP R-HSA-3371378 4.717617e-01 0.326 0 0
Dimerization of procaspase-8 R-HSA-69416 4.717617e-01 0.326 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.717617e-01 0.326 0 0
Nucleotide salvage defects R-HSA-9734207 4.717617e-01 0.326 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.717617e-01 0.326 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 4.717617e-01 0.326 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.717617e-01 0.326 0 0
PCP/CE pathway R-HSA-4086400 4.729491e-01 0.325 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.740321e-01 0.324 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.793100e-01 0.319 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.819385e-01 0.317 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.819385e-01 0.317 0 0
Removal of the Flap Intermediate R-HSA-69166 4.819385e-01 0.317 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.819385e-01 0.317 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.819385e-01 0.317 0 0
Cellular response to hypoxia R-HSA-1234174 4.854685e-01 0.314 0 0
Platelet degranulation R-HSA-114608 4.872048e-01 0.312 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.875762e-01 0.312 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.875762e-01 0.312 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.875762e-01 0.312 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.875762e-01 0.312 0 0
IRE1alpha activates chaperones R-HSA-381070 4.925877e-01 0.308 0 0
Interferon gamma signaling R-HSA-877300 4.931767e-01 0.307 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.940249e-01 0.306 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.966801e-01 0.304 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.986577e-01 0.302 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.986577e-01 0.302 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.003717e-01 0.301 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.003717e-01 0.301 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.003717e-01 0.301 0 0
Extension of Telomeres R-HSA-180786 5.018895e-01 0.299 0 0
PLC-gamma1 signalling R-HSA-167021 5.145351e-01 0.289 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.145351e-01 0.289 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.145351e-01 0.289 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.145351e-01 0.289 0 0
Invadopodia formation R-HSA-8941237 5.145351e-01 0.289 0 0
Defective ABCD4 causes MAHCJ R-HSA-5683329 5.145351e-01 0.289 0 0
Signalling to STAT3 R-HSA-198745 5.145351e-01 0.289 0 0
Classical Kir channels R-HSA-1296053 5.145351e-01 0.289 0 0
Defective CYP7B1 causes SPG5A and CBAS3 R-HSA-5579013 5.145351e-01 0.289 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.145351e-01 0.289 0 0
MET activates STAT3 R-HSA-8875791 5.145351e-01 0.289 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 5.145351e-01 0.289 0 0
Intracellular oxygen transport R-HSA-8981607 5.145351e-01 0.289 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.145351e-01 0.289 0 0
Histamine receptors R-HSA-390650 5.145351e-01 0.289 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.145351e-01 0.289 0 0
FasL/ CD95L signaling R-HSA-75157 5.145351e-01 0.289 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 5.173497e-01 0.286 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.173497e-01 0.286 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 5.173497e-01 0.286 0 0
CASP8 activity is inhibited R-HSA-5218900 5.173497e-01 0.286 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 5.173497e-01 0.286 0 0
Calcineurin activates NFAT R-HSA-2025928 5.173497e-01 0.286 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 5.173497e-01 0.286 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.173497e-01 0.286 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.173497e-01 0.286 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.173497e-01 0.286 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.173497e-01 0.286 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.173497e-01 0.286 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.175946e-01 0.286 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.175946e-01 0.286 0 0
Biotin transport and metabolism R-HSA-196780 5.175946e-01 0.286 0 0
DNA Damage Reversal R-HSA-73942 5.175946e-01 0.286 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.175946e-01 0.286 0 0
Lagging Strand Synthesis R-HSA-69186 5.178436e-01 0.286 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.178436e-01 0.286 0 0
G-protein activation R-HSA-202040 5.178436e-01 0.286 0 0
ERK/MAPK targets R-HSA-198753 5.178436e-01 0.286 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.178436e-01 0.286 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.181804e-01 0.286 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.181804e-01 0.286 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.181804e-01 0.286 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.185780e-01 0.285 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.185780e-01 0.285 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.190124e-01 0.285 0 0
Diseases of DNA repair R-HSA-9675135 5.194677e-01 0.284 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.199342e-01 0.284 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.208780e-01 0.283 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 5.227375e-01 0.282 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.380218e-01 0.269 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.399709e-01 0.268 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.409722e-01 0.267 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.409722e-01 0.267 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.409722e-01 0.267 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.423582e-01 0.266 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.443267e-01 0.264 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.443267e-01 0.264 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.443267e-01 0.264 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.502607e-01 0.259 0 0
Synthesis of DNA R-HSA-69239 5.514750e-01 0.258 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.518814e-01 0.258 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.518814e-01 0.258 0 0
Killing mechanisms R-HSA-9664420 5.518814e-01 0.258 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.518814e-01 0.258 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.518814e-01 0.258 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.518814e-01 0.258 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.518814e-01 0.258 0 0
NGF-stimulated transcription R-HSA-9031628 5.601240e-01 0.252 0 0
Gluconeogenesis R-HSA-70263 5.601240e-01 0.252 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 5.602389e-01 0.252 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.602389e-01 0.252 0 0
MAPK3 (ERK1) activation R-HSA-110056 5.602389e-01 0.252 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.602389e-01 0.252 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.602389e-01 0.252 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.602389e-01 0.252 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.602389e-01 0.252 0 0
Formation of apoptosome R-HSA-111458 5.602389e-01 0.252 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.602389e-01 0.252 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.603141e-01 0.252 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.625081e-01 0.250 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.625081e-01 0.250 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.625081e-01 0.250 0 0
Oncogene Induced Senescence R-HSA-2559585 5.656086e-01 0.247 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.656086e-01 0.247 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.697809e-01 0.244 0 0
DARPP-32 events R-HSA-180024 5.697809e-01 0.244 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.750446e-01 0.240 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.756796e-01 0.240 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.756796e-01 0.240 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.756796e-01 0.240 0 0
LDL clearance R-HSA-8964038 5.756796e-01 0.240 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.756796e-01 0.240 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 5.769217e-01 0.239 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.769217e-01 0.239 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.798758e-01 0.237 0 0
HCN channels R-HSA-1296061 5.798758e-01 0.237 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.798758e-01 0.237 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.798758e-01 0.237 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.798758e-01 0.237 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.798758e-01 0.237 0 0
Regulation of gap junction activity R-HSA-191650 5.798758e-01 0.237 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.798758e-01 0.237 0 0
Dopamine receptors R-HSA-390651 5.798758e-01 0.237 0 0
Interleukin-38 signaling R-HSA-9007892 5.798758e-01 0.237 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.846779e-01 0.233 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.862044e-01 0.232 0 0
Parasite infection R-HSA-9664407 5.862044e-01 0.232 0 0
Leishmania phagocytosis R-HSA-9664417 5.862044e-01 0.232 0 0
G1/S-Specific Transcription R-HSA-69205 5.882747e-01 0.230 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.882747e-01 0.230 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.944778e-01 0.226 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.979431e-01 0.223 0 0
PI3K Cascade R-HSA-109704 5.992274e-01 0.222 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.998837e-01 0.222 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.998837e-01 0.222 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.003299e-01 0.222 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 6.003299e-01 0.222 0 0
Suppression of apoptosis R-HSA-9635465 6.003299e-01 0.222 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.041307e-01 0.219 0 0
Signaling by FGFR R-HSA-190236 6.095586e-01 0.215 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.103101e-01 0.214 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 6.103101e-01 0.214 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.158993e-01 0.210 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.158993e-01 0.210 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.158993e-01 0.210 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.158993e-01 0.210 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.181115e-01 0.209 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.181115e-01 0.209 0 0
HCMV Late Events R-HSA-9610379 6.288385e-01 0.201 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 6.293657e-01 0.201 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.293657e-01 0.201 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.364253e-01 0.196 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.364253e-01 0.196 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.364253e-01 0.196 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.364253e-01 0.196 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.364253e-01 0.196 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.364253e-01 0.196 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.364253e-01 0.196 0 0
Defective F9 activation R-HSA-9673221 6.364253e-01 0.196 0 0
Activation of AKT2 R-HSA-165158 6.364253e-01 0.196 0 0
PTK6 Down-Regulation R-HSA-8849472 6.364253e-01 0.196 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.364253e-01 0.196 0 0
Activation of C3 and C5 R-HSA-174577 6.364253e-01 0.196 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.364253e-01 0.196 0 0
Inositol transporters R-HSA-429593 6.364253e-01 0.196 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.364253e-01 0.196 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 6.364253e-01 0.196 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 6.373146e-01 0.196 0 0
Signaling by FGFR in disease R-HSA-1226099 6.373146e-01 0.196 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.375990e-01 0.195 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.375990e-01 0.195 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.375990e-01 0.195 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 6.375990e-01 0.195 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.375990e-01 0.195 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.375990e-01 0.195 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.435784e-01 0.191 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 6.435784e-01 0.191 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.435784e-01 0.191 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.435784e-01 0.191 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.454925e-01 0.190 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.454925e-01 0.190 0 0
PKA activation in glucagon signalling R-HSA-164378 6.454925e-01 0.190 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.454925e-01 0.190 0 0
Mismatch Repair R-HSA-5358508 6.454925e-01 0.190 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.454925e-01 0.190 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.454925e-01 0.190 0 0
RAS processing R-HSA-9648002 6.523388e-01 0.186 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.523388e-01 0.186 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.523388e-01 0.186 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.523388e-01 0.186 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.545138e-01 0.184 0 0
G protein gated Potassium channels R-HSA-1296059 6.545138e-01 0.184 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.545138e-01 0.184 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.545138e-01 0.184 0 0
Regulated Necrosis R-HSA-5218859 6.581033e-01 0.182 0 0
Innate Immune System R-HSA-168249 6.587778e-01 0.181 0 0
Signaling by TGFB family members R-HSA-9006936 6.606178e-01 0.180 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.624154e-01 0.179 0 0
PI Metabolism R-HSA-1483255 6.631841e-01 0.178 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.635417e-01 0.178 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.635417e-01 0.178 0 0
Nuclear RNA decay R-HSA-9930044 6.635417e-01 0.178 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.635417e-01 0.178 0 0
Scavenging by Class F Receptors R-HSA-3000484 6.720795e-01 0.173 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.720795e-01 0.173 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.720795e-01 0.173 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 6.720795e-01 0.173 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.734313e-01 0.172 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.734313e-01 0.172 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.734313e-01 0.172 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.734313e-01 0.172 0 0
Maturation of nucleoprotein R-HSA-9694631 6.734313e-01 0.172 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.736580e-01 0.172 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.784896e-01 0.168 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.784896e-01 0.168 0 0
TRP channels R-HSA-3295583 6.784896e-01 0.168 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 6.803654e-01 0.167 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.847772e-01 0.164 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.853660e-01 0.164 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.853660e-01 0.164 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.853660e-01 0.164 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.853660e-01 0.164 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.853660e-01 0.164 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 6.853660e-01 0.164 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.853660e-01 0.164 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.853660e-01 0.164 0 0
PKB-mediated events R-HSA-109703 6.853660e-01 0.164 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.853660e-01 0.164 0 0
Cam-PDE 1 activation R-HSA-111957 6.853660e-01 0.164 0 0
PDE3B signalling R-HSA-165160 6.853660e-01 0.164 0 0
Ceramide signalling R-HSA-193681 6.853660e-01 0.164 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.853660e-01 0.164 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.853660e-01 0.164 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 6.853660e-01 0.164 0 0
VEGF ligand-receptor interactions R-HSA-194313 6.853660e-01 0.164 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 6.853660e-01 0.164 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.853660e-01 0.164 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.853660e-01 0.164 0 0
Developmental Cell Lineages R-HSA-9734767 6.975669e-01 0.156 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.997126e-01 0.155 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.997126e-01 0.155 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.997126e-01 0.155 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.997126e-01 0.155 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.012787e-01 0.154 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.012787e-01 0.154 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.012787e-01 0.154 0 0
Hedgehog 'on' state R-HSA-5632684 7.034825e-01 0.153 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.038466e-01 0.153 0 0
Diseases of nucleotide metabolism R-HSA-9735804 7.038466e-01 0.153 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.038466e-01 0.153 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.050878e-01 0.152 0 0
Dual Incision in GG-NER R-HSA-5696400 7.050878e-01 0.152 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.050878e-01 0.152 0 0
Ion transport by P-type ATPases R-HSA-936837 7.113997e-01 0.148 0 0
Adipogenesis R-HSA-9843745 7.171985e-01 0.144 0 0
Telomere Extension By Telomerase R-HSA-171319 7.228779e-01 0.141 0 0
HIV elongation arrest and recovery R-HSA-167287 7.228779e-01 0.141 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.228779e-01 0.141 0 0
Insulin receptor recycling R-HSA-77387 7.228779e-01 0.141 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.228779e-01 0.141 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.243521e-01 0.140 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.243521e-01 0.140 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.243521e-01 0.140 0 0
Chylomicron clearance R-HSA-8964026 7.277212e-01 0.138 0 0
Metabolism of ingested MeSeO2H into MeSeH R-HSA-5263617 7.277212e-01 0.138 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.277212e-01 0.138 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.277212e-01 0.138 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.277212e-01 0.138 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.277212e-01 0.138 0 0
MET Receptor Activation R-HSA-6806942 7.277212e-01 0.138 0 0
Lactose synthesis R-HSA-5653890 7.277212e-01 0.138 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.277212e-01 0.138 0 0
HDL clearance R-HSA-8964011 7.277212e-01 0.138 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.314372e-01 0.136 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.317284e-01 0.136 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.330061e-01 0.135 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.330061e-01 0.135 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.330061e-01 0.135 0 0
Malate-aspartate shuttle R-HSA-9856872 7.330061e-01 0.135 0 0
Triglyceride catabolism R-HSA-163560 7.429121e-01 0.129 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.432947e-01 0.129 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.432947e-01 0.129 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.432947e-01 0.129 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.432947e-01 0.129 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.444500e-01 0.128 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.473812e-01 0.126 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.473812e-01 0.126 0 0
ER-Phagosome pathway R-HSA-1236974 7.541506e-01 0.123 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.596841e-01 0.119 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.596841e-01 0.119 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.596841e-01 0.119 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.596841e-01 0.119 0 0
Proteasome assembly R-HSA-9907900 7.605747e-01 0.119 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.617284e-01 0.118 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.625448e-01 0.118 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.643086e-01 0.117 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.643086e-01 0.117 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.643086e-01 0.117 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.643086e-01 0.117 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.643086e-01 0.117 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.643768e-01 0.117 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 7.643768e-01 0.117 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.643768e-01 0.117 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.643768e-01 0.117 0 0
Recycling of eIF2:GDP R-HSA-72731 7.643768e-01 0.117 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.643768e-01 0.117 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.643768e-01 0.117 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.643768e-01 0.117 0 0
PTK6 Expression R-HSA-8849473 7.643768e-01 0.117 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.643768e-01 0.117 0 0
VLDL clearance R-HSA-8964046 7.643768e-01 0.117 0 0
Netrin mediated repulsion signals R-HSA-418886 7.643768e-01 0.117 0 0
Regulation of PTEN localization R-HSA-8948747 7.643768e-01 0.117 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.643768e-01 0.117 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.643768e-01 0.117 0 0
Maturation of replicase proteins R-HSA-9694301 7.643768e-01 0.117 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.688435e-01 0.114 0 0
FGFR2 alternative splicing R-HSA-6803529 7.688435e-01 0.114 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.688435e-01 0.114 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.688435e-01 0.114 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.688435e-01 0.114 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.688435e-01 0.114 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.759371e-01 0.110 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.806518e-01 0.108 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 7.840204e-01 0.106 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 7.840204e-01 0.106 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.840204e-01 0.106 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.840204e-01 0.106 0 0
Activation of SMO R-HSA-5635838 7.840204e-01 0.106 0 0
Interleukin-20 family signaling R-HSA-8854691 7.887926e-01 0.103 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.960994e-01 0.099 0 0
RSK activation R-HSA-444257 7.960994e-01 0.099 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.960994e-01 0.099 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.960994e-01 0.099 0 0
phospho-PLA2 pathway R-HSA-111995 7.960994e-01 0.099 0 0
MET receptor recycling R-HSA-8875656 7.960994e-01 0.099 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.960994e-01 0.099 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.960994e-01 0.099 0 0
Co-stimulation by ICOS R-HSA-9927354 7.960994e-01 0.099 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.960994e-01 0.099 0 0
Adrenoceptors R-HSA-390696 7.960994e-01 0.099 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.960994e-01 0.099 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.960994e-01 0.099 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.960994e-01 0.099 0 0
Interleukin-9 signaling R-HSA-8985947 7.960994e-01 0.099 0 0
Calcitonin-like ligand receptors R-HSA-419812 7.960994e-01 0.099 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.976448e-01 0.098 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.976448e-01 0.098 0 0
G alpha (z) signalling events R-HSA-418597 8.030600e-01 0.095 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.061616e-01 0.094 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.061616e-01 0.094 0 0
Response to metal ions R-HSA-5660526 8.061616e-01 0.094 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.063849e-01 0.093 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.072895e-01 0.093 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.072895e-01 0.093 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.072895e-01 0.093 0 0
Interleukin-6 family signaling R-HSA-6783589 8.072895e-01 0.093 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.215327e-01 0.085 0 0
Interleukin-21 signaling R-HSA-9020958 8.235527e-01 0.084 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.235527e-01 0.084 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.235527e-01 0.084 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.235527e-01 0.084 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.235527e-01 0.084 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.235527e-01 0.084 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.244001e-01 0.084 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.244001e-01 0.084 0 0
Formation of the nephric duct R-HSA-9830364 8.244001e-01 0.084 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.262578e-01 0.083 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.262578e-01 0.083 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.262578e-01 0.083 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.262578e-01 0.083 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.262578e-01 0.083 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.262578e-01 0.083 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.284308e-01 0.082 0 0
DNA Damage Bypass R-HSA-73893 8.299950e-01 0.081 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.401944e-01 0.076 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.401944e-01 0.076 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.401944e-01 0.076 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.401944e-01 0.076 0 0
Signal amplification R-HSA-392518 8.423033e-01 0.075 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.423033e-01 0.075 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.423033e-01 0.075 0 0
Apoptotic factor-mediated response R-HSA-111471 8.444580e-01 0.073 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.446198e-01 0.073 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.452623e-01 0.073 0 0
Activation of GABAB receptors R-HSA-991365 8.470070e-01 0.072 0 0
GABA B receptor activation R-HSA-977444 8.470070e-01 0.072 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.470070e-01 0.072 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 8.473111e-01 0.072 0 0
DNA replication initiation R-HSA-68952 8.473111e-01 0.072 0 0
Binding and entry of HIV virion R-HSA-173107 8.473111e-01 0.072 0 0
Metabolism of serotonin R-HSA-380612 8.473111e-01 0.072 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.473111e-01 0.072 0 0
Pexophagy R-HSA-9664873 8.473111e-01 0.072 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.473111e-01 0.072 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.473111e-01 0.072 0 0
Interleukin-27 signaling R-HSA-9020956 8.473111e-01 0.072 0 0
Maturation of spike protein R-HSA-9683686 8.473111e-01 0.072 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.490450e-01 0.071 0 0
Cardiac conduction R-HSA-5576891 8.504697e-01 0.070 0 0
RSV-host interactions R-HSA-9833110 8.535396e-01 0.069 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.547439e-01 0.068 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.547439e-01 0.068 0 0
Infectious disease R-HSA-5663205 8.578033e-01 0.067 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.585710e-01 0.066 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.587381e-01 0.066 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.590791e-01 0.066 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.609085e-01 0.065 0 0
Translesion Synthesis by POLH R-HSA-110320 8.609085e-01 0.065 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.609085e-01 0.065 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.609085e-01 0.065 0 0
Specification of the neural plate border R-HSA-9834899 8.609085e-01 0.065 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.610487e-01 0.065 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.678716e-01 0.062 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.678716e-01 0.062 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.678716e-01 0.062 0 0
vRNA Synthesis R-HSA-192814 8.678716e-01 0.062 0 0
vRNP Assembly R-HSA-192905 8.678716e-01 0.062 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.678716e-01 0.062 0 0
Vitamin B1 (thiamin) metabolism R-HSA-196819 8.678716e-01 0.062 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.678716e-01 0.062 0 0
Transport of RCbl within the body R-HSA-9758890 8.678716e-01 0.062 0 0
Prostanoid ligand receptors R-HSA-391908 8.678716e-01 0.062 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.678716e-01 0.062 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.678716e-01 0.062 0 0
Aquaporin-mediated transport R-HSA-445717 8.685627e-01 0.061 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.685627e-01 0.061 0 0
Amine ligand-binding receptors R-HSA-375280 8.693942e-01 0.061 0 0
Integrin cell surface interactions R-HSA-216083 8.717138e-01 0.060 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.757503e-01 0.058 0 0
Signaling by NODAL R-HSA-1181150 8.757503e-01 0.058 0 0
Creatine metabolism R-HSA-71288 8.757503e-01 0.058 0 0
Gastrulation R-HSA-9758941 8.783623e-01 0.056 0 0
Voltage gated Potassium channels R-HSA-1296072 8.783624e-01 0.056 0 0
Collagen chain trimerization R-HSA-8948216 8.783624e-01 0.056 0 0
Glucagon-type ligand receptors R-HSA-420092 8.803991e-01 0.055 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.822015e-01 0.054 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.856646e-01 0.053 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.856646e-01 0.053 0 0
ERKs are inactivated R-HSA-202670 8.856646e-01 0.053 0 0
Sodium/Calcium exchangers R-HSA-425561 8.856646e-01 0.053 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.856646e-01 0.053 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.856646e-01 0.053 0 0
MET promotes cell motility R-HSA-8875878 8.886812e-01 0.051 0 0
Elastic fibre formation R-HSA-1566948 8.886812e-01 0.051 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.889470e-01 0.051 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.891183e-01 0.051 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.891183e-01 0.051 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.891183e-01 0.051 0 0
SLC transporter disorders R-HSA-5619102 8.908706e-01 0.050 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.982258e-01 0.047 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.990445e-01 0.046 0 0
IRAK1 recruits IKK complex R-HSA-937039 9.010623e-01 0.045 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 9.010623e-01 0.045 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.010623e-01 0.045 0 0
Synthesis of GDP-mannose R-HSA-446205 9.010623e-01 0.045 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 9.010623e-01 0.045 0 0
Interleukin-35 Signalling R-HSA-8984722 9.010623e-01 0.045 0 0
OAS antiviral response R-HSA-8983711 9.010623e-01 0.045 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.011402e-01 0.045 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.011402e-01 0.045 0 0
Attachment and Entry R-HSA-9694614 9.011402e-01 0.045 0 0
Serine metabolism R-HSA-977347 9.011402e-01 0.045 0 0
Glutathione synthesis and recycling R-HSA-174403 9.011402e-01 0.045 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.019393e-01 0.045 0 0
Dectin-2 family R-HSA-5621480 9.066234e-01 0.043 0 0
HIV Transcription Elongation R-HSA-167169 9.070416e-01 0.042 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.070416e-01 0.042 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.070416e-01 0.042 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.077170e-01 0.042 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.119361e-01 0.040 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.119361e-01 0.040 0 0
Cellular hexose transport R-HSA-189200 9.119361e-01 0.040 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.119361e-01 0.040 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.119361e-01 0.040 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.119361e-01 0.040 0 0
Dual incision in TC-NER R-HSA-6782135 9.137056e-01 0.039 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.143872e-01 0.039 0 0
OGDH complex synthesizes succinyl-CoA from 2-OG R-HSA-9853506 9.143872e-01 0.039 0 0
Processing of SMDT1 R-HSA-8949664 9.143872e-01 0.039 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.143872e-01 0.039 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.143872e-01 0.039 0 0
Regulation of beta-cell development R-HSA-186712 9.203159e-01 0.036 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.216181e-01 0.035 0 0
Carnitine shuttle R-HSA-200425 9.216181e-01 0.035 0 0
Syndecan interactions R-HSA-3000170 9.216181e-01 0.035 0 0
Translation of Structural Proteins R-HSA-9683701 9.226624e-01 0.035 0 0
ABC-family proteins mediated transport R-HSA-382556 9.246677e-01 0.034 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.259182e-01 0.033 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.259182e-01 0.033 0 0
Hydrolysis of LPC R-HSA-1483115 9.259182e-01 0.033 0 0
Biosynthesis of protectins R-HSA-9018681 9.259182e-01 0.033 0 0
cGMP effects R-HSA-418457 9.259182e-01 0.033 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.259182e-01 0.033 0 0
Physiological factors R-HSA-5578768 9.259182e-01 0.033 0 0
Zinc transporters R-HSA-435354 9.259182e-01 0.033 0 0
Prolactin receptor signaling R-HSA-1170546 9.259182e-01 0.033 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.259182e-01 0.033 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.259182e-01 0.033 0 0
HDL assembly R-HSA-8963896 9.259182e-01 0.033 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.259182e-01 0.033 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.259182e-01 0.033 0 0
tRNA Aminoacylation R-HSA-379724 9.264786e-01 0.033 0 0
Metabolism of polyamines R-HSA-351202 9.264786e-01 0.033 0 0
ABC transporter disorders R-HSA-5619084 9.281094e-01 0.032 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.302903e-01 0.031 0 0
Complex III assembly R-HSA-9865881 9.302903e-01 0.031 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.348248e-01 0.029 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.358966e-01 0.029 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.358966e-01 0.029 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.358966e-01 0.029 0 0
Translesion synthesis by REV1 R-HSA-110312 9.358966e-01 0.029 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.380490e-01 0.028 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.380490e-01 0.028 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.380490e-01 0.028 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.388034e-01 0.027 0 0
tRNA processing R-HSA-72306 9.395826e-01 0.027 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.412789e-01 0.026 0 0
PERK regulates gene expression R-HSA-381042 9.412789e-01 0.026 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.412789e-01 0.026 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.421101e-01 0.026 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.441733e-01 0.025 0 0
Translesion synthesis by POLI R-HSA-5656121 9.445316e-01 0.025 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.445316e-01 0.025 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.445316e-01 0.025 0 0
Regulation of BACH1 activity R-HSA-9708530 9.445316e-01 0.025 0 0
Attachment and Entry R-HSA-9678110 9.445316e-01 0.025 0 0
Virus Assembly and Release R-HSA-168268 9.445316e-01 0.025 0 0
MET activates PTK2 signaling R-HSA-8874081 9.449830e-01 0.025 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.449830e-01 0.025 0 0
Neddylation R-HSA-8951664 9.497414e-01 0.022 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.497742e-01 0.022 0 0
Potential therapeutics for SARS R-HSA-9679191 9.503844e-01 0.022 0 0
Insulin processing R-HSA-264876 9.511735e-01 0.022 0 0
Regulation of insulin secretion R-HSA-422356 9.516466e-01 0.022 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.518936e-01 0.021 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.518936e-01 0.021 0 0
Translesion synthesis by POLK R-HSA-5655862 9.520038e-01 0.021 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.520038e-01 0.021 0 0
Heme assimilation R-HSA-9927020 9.520038e-01 0.021 0 0
Glycine degradation R-HSA-6783984 9.520038e-01 0.021 0 0
Synthesis of PG R-HSA-1483148 9.520038e-01 0.021 0 0
Coenzyme A biosynthesis R-HSA-196783 9.520038e-01 0.021 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.520038e-01 0.021 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.520038e-01 0.021 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.520038e-01 0.021 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.538013e-01 0.021 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.543368e-01 0.020 0 0
Iron uptake and transport R-HSA-917937 9.544218e-01 0.020 0 0
Disease R-HSA-1643685 9.544691e-01 0.020 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.566951e-01 0.019 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.566951e-01 0.019 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.566951e-01 0.019 0 0
Pyroptosis R-HSA-5620971 9.566951e-01 0.019 0 0
Purine salvage R-HSA-74217 9.572531e-01 0.019 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.584697e-01 0.018 0 0
Choline catabolism R-HSA-6798163 9.584697e-01 0.018 0 0
Glycogen storage diseases R-HSA-3229121 9.584697e-01 0.018 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.584697e-01 0.018 0 0
Interferon alpha/beta signaling R-HSA-909733 9.595836e-01 0.018 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.609610e-01 0.017 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.609610e-01 0.017 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.612669e-01 0.017 0 0
Pentose phosphate pathway R-HSA-71336 9.616021e-01 0.017 0 0
Transcription of the HIV genome R-HSA-167172 9.624065e-01 0.017 0 0
PPARA activates gene expression R-HSA-1989781 9.629949e-01 0.016 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.640650e-01 0.016 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.640650e-01 0.016 0 0
Polo-like kinase mediated events R-HSA-156711 9.640650e-01 0.016 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.640650e-01 0.016 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.640650e-01 0.016 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.640650e-01 0.016 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.641493e-01 0.016 0 0
Triglyceride metabolism R-HSA-8979227 9.643939e-01 0.016 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.655324e-01 0.015 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.655324e-01 0.015 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.655324e-01 0.015 0 0
Glycogen metabolism R-HSA-8982491 9.655324e-01 0.015 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.655324e-01 0.015 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.659965e-01 0.015 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.671907e-01 0.014 0 0
GABA receptor activation R-HSA-977443 9.675468e-01 0.014 0 0
RAB geranylgeranylation R-HSA-8873719 9.675468e-01 0.014 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.689066e-01 0.014 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.689066e-01 0.014 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.689066e-01 0.014 0 0
Other interleukin signaling R-HSA-449836 9.689066e-01 0.014 0 0
Diseases of hemostasis R-HSA-9671793 9.689066e-01 0.014 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.689066e-01 0.014 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.689066e-01 0.014 0 0
Cargo concentration in the ER R-HSA-5694530 9.698942e-01 0.013 0 0
Collagen degradation R-HSA-1442490 9.704399e-01 0.013 0 0
The phototransduction cascade R-HSA-2514856 9.706335e-01 0.013 0 0
Potassium Channels R-HSA-1296071 9.710157e-01 0.013 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.722818e-01 0.012 0 0
HIV Transcription Initiation R-HSA-167161 9.722818e-01 0.012 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.722818e-01 0.012 0 0
Intra-Golgi traffic R-HSA-6811438 9.722818e-01 0.012 0 0
Mitochondrial protein import R-HSA-1268020 9.730924e-01 0.012 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.730962e-01 0.012 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.730962e-01 0.012 0 0
Melanin biosynthesis R-HSA-5662702 9.730962e-01 0.012 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.730962e-01 0.012 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.730962e-01 0.012 0 0
Glycogen synthesis R-HSA-3322077 9.730962e-01 0.012 0 0
Pregnenolone biosynthesis R-HSA-196108 9.730962e-01 0.012 0 0
Protein hydroxylation R-HSA-9629569 9.730962e-01 0.012 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.730962e-01 0.012 0 0
Complex I biogenesis R-HSA-6799198 9.755223e-01 0.011 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.767215e-01 0.010 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.767215e-01 0.010 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.767215e-01 0.010 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.767215e-01 0.010 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.767215e-01 0.010 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.767215e-01 0.010 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.767215e-01 0.010 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.767215e-01 0.010 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.777649e-01 0.010 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.791696e-01 0.009 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.791696e-01 0.009 0 0
Heme degradation R-HSA-189483 9.791696e-01 0.009 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.793947e-01 0.009 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.798584e-01 0.009 0 0
Androgen biosynthesis R-HSA-193048 9.798584e-01 0.009 0 0
Ribavirin ADME R-HSA-9755088 9.798584e-01 0.009 0 0
Assembly Of The HIV Virion R-HSA-175474 9.798584e-01 0.009 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.798584e-01 0.009 0 0
Surfactant metabolism R-HSA-5683826 9.801026e-01 0.009 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.805557e-01 0.009 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.805557e-01 0.009 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.815937e-01 0.008 0 0
Signaling by NOTCH2 R-HSA-1980145 9.815937e-01 0.008 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.815937e-01 0.008 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.816394e-01 0.008 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.822046e-01 0.008 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.825728e-01 0.008 0 0
Ethanol oxidation R-HSA-71384 9.825728e-01 0.008 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.825728e-01 0.008 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.833369e-01 0.007 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.837429e-01 0.007 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.846719e-01 0.007 0 0
Interleukin-10 signaling R-HSA-6783783 9.846719e-01 0.007 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.849215e-01 0.007 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.849215e-01 0.007 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.849215e-01 0.007 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.849215e-01 0.007 0 0
Formation of the ureteric bud R-HSA-9830674 9.849215e-01 0.007 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.849215e-01 0.007 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.849215e-01 0.007 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.851617e-01 0.006 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.856474e-01 0.006 0 0
Synthesis of PC R-HSA-1483191 9.857889e-01 0.006 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.869538e-01 0.006 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.869538e-01 0.006 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.869538e-01 0.006 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.869538e-01 0.006 0 0
Peroxisomal protein import R-HSA-9033241 9.871012e-01 0.006 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.871012e-01 0.006 0 0
Metal ion SLC transporters R-HSA-425410 9.873103e-01 0.006 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.873339e-01 0.006 0 0
NCAM1 interactions R-HSA-419037 9.873339e-01 0.006 0 0
G alpha (s) signalling events R-HSA-418555 9.873717e-01 0.006 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.887123e-01 0.005 0 0
Hyaluronan degradation R-HSA-2160916 9.887123e-01 0.005 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.887123e-01 0.005 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.887123e-01 0.005 0 0
Laminin interactions R-HSA-3000157 9.887123e-01 0.005 0 0
ECM proteoglycans R-HSA-3000178 9.887581e-01 0.005 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.888266e-01 0.005 0 0
Nucleotide salvage R-HSA-8956321 9.895573e-01 0.005 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.901472e-01 0.004 0 0
Sphingolipid catabolism R-HSA-9845614 9.902338e-01 0.004 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.902338e-01 0.004 0 0
Signaling by BMP R-HSA-201451 9.915504e-01 0.004 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.915504e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.915504e-01 0.004 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.915504e-01 0.004 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.915504e-01 0.004 0 0
Maturation of spike protein R-HSA-9694548 9.923469e-01 0.003 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.924777e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.926441e-01 0.003 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.926895e-01 0.003 0 0
Pyrimidine salvage R-HSA-73614 9.926895e-01 0.003 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.928452e-01 0.003 0 0
Ion channel transport R-HSA-983712 9.931996e-01 0.003 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.932586e-01 0.003 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.932586e-01 0.003 0 0
Heme biosynthesis R-HSA-189451 9.932586e-01 0.003 0 0
mRNA Capping R-HSA-72086 9.936751e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.936751e-01 0.003 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.936751e-01 0.003 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.936751e-01 0.003 0 0
Translation of Structural Proteins R-HSA-9694635 9.938644e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.940636e-01 0.003 0 0
Pyruvate metabolism R-HSA-70268 9.940801e-01 0.003 0 0
Neurotransmitter clearance R-HSA-112311 9.945279e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.950046e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.950895e-01 0.002 0 0
Budding and maturation of HIV virion R-HSA-162588 9.952657e-01 0.002 0 0
G alpha (q) signalling events R-HSA-416476 9.953711e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.954010e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.955905e-01 0.002 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.955905e-01 0.002 0 0
Stimuli-sensing channels R-HSA-2672351 9.957130e-01 0.002 0 0
DAG1 glycosylations R-HSA-8931838 9.959041e-01 0.002 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.959539e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.960575e-01 0.002 0 0
Protein localization R-HSA-9609507 9.964507e-01 0.002 0 0
Recycling of bile acids and salts R-HSA-159418 9.964564e-01 0.002 0 0
Metabolism of porphyrins R-HSA-189445 9.964696e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.964696e-01 0.002 0 0
Post-translational protein modification R-HSA-597592 9.967586e-01 0.001 0 0
Purine catabolism R-HSA-74259 9.968398e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.968710e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.970403e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.973478e-01 0.001 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.973478e-01 0.001 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.973478e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.974709e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.978763e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.979042e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.980150e-01 0.001 0 0
HS-GAG biosynthesis R-HSA-2022928 9.980150e-01 0.001 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.980150e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.980261e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.980454e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.981445e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.981759e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.982827e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.982827e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.983873e-01 0.001 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.985144e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.985490e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.986378e-01 0.001 0 0
Kidney development R-HSA-9830369 9.986378e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.986948e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.988882e-01 0.000 0 0
Tryptophan catabolism R-HSA-71240 9.988882e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.989847e-01 0.000 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.990382e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.990532e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.991474e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.991618e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.991728e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.992401e-01 0.000 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.993774e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.993774e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.994135e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.994252e-01 0.000 0 0
Methylation R-HSA-156581 9.994614e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.994614e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.994962e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.996984e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.997391e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.997391e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997724e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997724e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.998000e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998007e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.998048e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.998048e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.998319e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.998429e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.998540e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.998664e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.998846e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998897e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.998907e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999055e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999213e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999218e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999276e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999389e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999395e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999477e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999543e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999618e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999679e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999704e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999741e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999761e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999807e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999874e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999876e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999893e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999920e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999920e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999968e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999975e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999975e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999978e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999980e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999985e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999991e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999992e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999994e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999995e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999996e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999997e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999998e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999998e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999998e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999998e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Initial triggering of complement R-HSA-166663 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways