HIPK4

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
O00115	S70	Sugiyama	DNASE2 DNASE2A DNL2	QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00429	S126	Sugiyama	DNM1L DLP1 DRP1	EIRQEIENETERISGNNKGVsPEPIHLKIFSPNVVNLTLVD
O00571	S591	Sugiyama	DDX3X DBX DDX3	LENMAyEHHyKGssRGRSKssRFsGGFGARDYRQssGAsss
O00571	S594	Sugiyama	DDX3X DBX DDX3	MAyEHHyKGssRGRSKssRFsGGFGARDYRQssGAssssFs
O15037	S291	Sugiyama	KHNYN KIAA0323	GWKELPGEEAWEREVALRPQsVGGGAREsAPLKGKALGKEE
O15160	S258	Sugiyama	POLR1C POLR1E	DITLLEPVEGEAAEELSRCFsPGVIEVQEVQGKKVARVANP
O60716	S252	Sugiyama	CTNND1 KIAA0384	sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O75128	S1224	Sugiyama	COBL KIAA0633	PAIPPPPPPPSQALSAPRTAsRFstGtLSNTADARQALMDA
O75390	S453	Sugiyama	CS	LAQLIWSRALGFPLERPKSMsTEGLMKFVDSKSG_______
O95155	S79	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	NMtPAtsPIGASGVAHRsQssEGVssLsssPsNsLEtQsQs
O95816	S208	Sugiyama	BAG2	IKLLEHSKGAGSKTLQQNAEsRFN_________________
O95817	S399	Sugiyama	BAG3 BIS	GPsAVPssPKsVAtEERAAPsTAPAEAtPPKPGEAEAPPKH
P00558	S415	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	GGGAsLELLEGKVLPGVDALsNI__________________
P04406	S210	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04637	S9	GPS6\|EPSD	TP53 P53	____________MEEPQsDPsVEPPLsQEtFsDLWKLLPEN
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05455	S94	Sugiyama	SSB	KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P06744	S107	Sugiyama	GPI	GEKINyTEGRAVLHVALRNRsNtPILVDGKDVMPEVNKVLD
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P08238	S45	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P09382	S63	Sugiyama	LGALS1	CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P11142	T38	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11532	S3623	Sugiyama	DMD	EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P13639	S593	Sugiyama	EEF2 EF2	SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P14618	S37	Sugiyama	PKM OIP3 PK2 PK3 PKM2	QLHAAMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRs
P14618	S55	Sugiyama	PKM OIP3 PK2 PK3 PKM2	IDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMNVARLN
P14625	S106	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625	S515	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P17174	S85	Sugiyama	GOT1	NsLNHEyLPILGLAEFRsCAsRLALGDDsPALKEKRVGGVQ
P17812	S575	Sugiyama	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P17987	S35	Sugiyama	TCP1 CCT1 CCTA	EtIRsQNVMAAAsIANIVKssLGPVGLDKMLVDDIGDVTIT
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22234	S27	Sugiyama	PAICS ADE2 AIRC PAIS	LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626	S212	Sugiyama	HNRNPA2B1 HNRPA2B1	EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23193	T136	Sugiyama	TCEA1 GTF2S TFIIS	RKDETNARDTyVsSFPRAPstsDsVRLKCREMLAAALRTGD
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25786	S14	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	_______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P26373	S109	Sugiyama	RPL13 BBC1 OK/SW-cl.46	KVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILFPR
P26641	S286	Sugiyama	EEF1G EF1G PRO1608	CEQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVA
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27695	S135	Sugiyama	APEX1 APE APE1 APEX APX HAP1 REF1	SHQYWSAPsDKEGysGVGLLsRQCPLKVsyGIGDEEHDQEG
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27824	S362	Sugiyama	CANX	WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30101	T485	Sugiyama	PDIA3 ERP57 ERP60 GRP58	KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931	T40	Sugiyama	HSPA1L	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P35613	S246	Sugiyama	BSG UNQ6505/PRO21383	VKssEHINEGEtAMLVCKSEsVPPVTDWAWyKITDSEDKAL
P35998	S89	Sugiyama	PSMC2 MSS1	DTGLAPPALWDLAADKQTLQsEQPLQVARCTKIINADSEDP
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P43243	S195	Sugiyama	MATR3 KIAA0723	RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P49790	S203	Sugiyama	NUP153	ttsGFssRAsDKDITVsKNtsLPPLWsPEAERsHsLsQHtA
P50454	S138	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	LSNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEH
P51812	S715	Sugiyama	RPS6KA3 ISPK1 MAPKAPK1B RSK2	APHLVKGAMAAtysALNRNQsPVLEPVGRsTLAQRRGIKKI
P53396	S656	Sugiyama	ACLY	IGNTGGMLDNILASKLyRPGsVAyVSRsGGMsNELNNIISR
P53992	S378	Sugiyama	SEC24C KIAA0079	TTNFLVKDQGNASPRYIRCTsyNIPCTSDMAKQAQVPLAAV
P54252	S260	Sugiyama	ATXN3 ATX3 MJD MJD1 SCA3	IDMEDEEADLRRAIQLsMQGssRNIsQDMtQtsGTNLTSEE
P54652	T39	Sugiyama	HSPA2	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P61353	S39	Sugiyama	RPL27	SGRKAVIVKNIDDGtsDRPysHALVAGIDRyPRKVTAAMGK
P61769	S31	Sugiyama	B2M CDABP0092 HDCMA22P	ALLSLSGLEAIQRTPKIQVysRHPAENGKSNFLNCYVsGFH
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62241	S4	Sugiyama	RPS8 OK/SW-cl.83	_________________MGIsRDNWHKRRKTGGKRKPYHKK
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62942	S9	Sugiyama	FKBP1A FKBP1 FKBP12	____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P67809	S209	Sugiyama	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P78347	S214	Sugiyama	GTF2I BAP135 WBSCR6	HVGGRVMVtDADRsILsPGGsCGPIKVKTEPTEDSGIsLEM
Q00613	S363	Sugiyama	HSF1 HSTF1	AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q00613	S375	Sugiyama	HSF1 HSTF1	TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q06210	S261	Sugiyama	GFPT1 GFAT GFPT	GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q08AD1	S1313	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	sLNtGDNEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWE
Q12792	S142	Sugiyama	TWF1 PTK9	FGTVKEDVSLHGYKKyLLsQssPAPLtAAEEELRQIKINEV
Q12792	S143	Sugiyama	TWF1 PTK9	GTVKEDVSLHGYKKyLLsQssPAPLtAAEEELRQIKINEVQ
Q13247	S303	Sugiyama	SRSF6 SFRS6 SRP55	ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13263	T415	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	LNAWTKSAEAFGKIVAERPGtNstGPAPMAPPRAPGPLSKQ
Q13263	T418	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	WTKSAEAFGKIVAERPGtNstGPAPMAPPRAPGPLSKQGsG
Q13283	S231	Sugiyama	G3BP1 G3BP	QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13283	S250	Sugiyama	G3BP1 G3BP	sssPAPADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGI
Q13283	S256	Sugiyama	G3BP1 G3BP	ADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGIPPHVVK
Q13573	S224	Sugiyama	SNW1 SKIIP SKIP	KDPMEPPRFKINKKIPRGPPsPPAPVMHsPsRKMTVKEQQE
Q14258	S100	Sugiyama	TRIM25 EFP RNF147 ZNF147	DLAREPPADVWtPPARAsAPsPNAQVACDHCLKEAAVKTCL
Q14677	S166	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14738	S598	Sugiyama	PPP2R5D	DVyTIKALEAHKRAEEFLTAsQEAL________________
Q14974	S12	Sugiyama	KPNB1 NTF97	_________MELITILEKtVsPDRLELEAAQKFLERAAVEN
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q15818	S91	Sugiyama	NPTX1	TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q3KQU3	S366	Sugiyama	MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464	GPQPDRTHPSAAVPVCPRsAsAsPLtPCSVTRSVHRCAPAG
Q6GYQ0	S797	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	EtGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDM
Q7Z2W4	T273	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q7Z6Z7	S2887	Sugiyama	HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272	LEEAVGDTSAAGSSEQPRAGsstPGDAPPAVAEVQGRSDGs
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86YP4	S100	Sugiyama	GATAD2A	DGPVDMRTSHSDMKSERRPPsPDVIVLsDNEQPssPRVNGL
Q8IWW6	S240	Sugiyama	ARHGAP12	SSSsTEQIRAttPPNQGRPDsPVyANLQELKISQSALPPLP
Q8IWW6	T231	Sugiyama	ARHGAP12	QDSEsGDELSSSsTEQIRAttPPNQGRPDsPVyANLQELKI
Q8IWX8	S823	Sugiyama	CHERP DAN26 SCAF6	KSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRLGEEN
Q8IWX8	S828	Sugiyama	CHERP DAN26 SCAF6	GRRRRsRsRsPtPPssAGLGsNsAPPIPDSRLGEENKGHQM
Q8IWX8	S830	Sugiyama	CHERP DAN26 SCAF6	RRRsRsRsPtPPssAGLGsNsAPPIPDSRLGEENKGHQMLV
Q8IWX8	T819	Sugiyama	CHERP DAN26 SCAF6	RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8N8S7	S125	Sugiyama	ENAH MENA	MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NE63	S298	Sugiyama	HIPK4	LERRKYMLKSLDQIETVNGGsVASRLTFPDREALAEHADLK
Q8NE63	S337	Sugiyama	HIPK4	LKSMVELIKRMLTWESHERIsPSAALRHPFVSMQQLRSAHE
Q8NE63	S406	Sugiyama	HIPK4	AEDGTPYYCLAEEKEAAGMGsVAGssPFFREEKAPGMQRAI
Q8NE63	S410	Sugiyama	HIPK4	TPYYCLAEEKEAAGMGsVAGssPFFREEKAPGMQRAIDQLD
Q8NE63	S411	Sugiyama	HIPK4	PYYCLAEEKEAAGMGsVAGssPFFREEKAPGMQRAIDQLDD
Q8NE63	S469	Sugiyama	HIPK4	AVSDMMVPLKAAItGHHVPDsGPEPILAFySSRLAGRHKAR
Q8NE63	S522	Sugiyama	HIPK4	SNLIRLSQVSPEDDRPCRGSsWEEGEHLGAsAEPLAILQRD
Q8NE63	S532	Sugiyama	HIPK4	PEDDRPCRGSsWEEGEHLGAsAEPLAILQRDEDGPNIDNMT
Q8NE63	T462	Sugiyama	HIPK4	WGETCTNAVSDMMVPLKAAItGHHVPDsGPEPILAFySSRL
Q8NE63	Y175	Sugiyama	HIPK4	KVIDFGSASIFSEVRYVKEPyIQSRFYRAPEILLGLPFCEK
Q8NE63	Y478	Sugiyama	HIPK4	KAAItGHHVPDsGPEPILAFySSRLAGRHKARKPPAGSKSD
Q8TD19	S855	Sugiyama	NEK9 KIAA1995 NEK8 NERCC	FsEsEKDTLPyEELQGLKVAsEAPLEHKPQVEAssPRLNPA
Q96BY7	S1395	Sugiyama	ATG2B C14orf103	ADMKPGAFQRRSKVDSSGRSsSRGPVLPEADQQMLRDLMSD
Q96JH7	S747	Sugiyama	VCPIP1 KIAA1850 VCIP135	MQKRKTEKLKQEQKGQPRtVsPstIRDGPssAPAtPtKAPy
Q96JH7	S756	Sugiyama	VCPIP1 KIAA1850 VCIP135	KQEQKGQPRtVsPstIRDGPssAPAtPtKAPysPtTSKEKK
Q96JH7	T750	Sugiyama	VCPIP1 KIAA1850 VCIP135	RKTEKLKQEQKGQPRtVsPstIRDGPssAPAtPtKAPysPt
Q9BQ39	S140	Sugiyama	DDX50	KSSDNKLEETLTREQKEGAFsNFPIsEEtIKLLKGRGVTYL
Q9BV68	S34	Sugiyama	RNF126	HCCsVEIVPRLPDYICPRCEsGFIEELPEETRSTENGSAPS
Q9C0C2	S672	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H4A3	S167	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	AVAGPAPSTVPSSTSKDRPVsQPsLVGsKEEPPPARsGsGG
Q9H6T3	T491	Sugiyama	RPAP3	ATGTTSKKNssQDDLFPTsDtPRAKVLKIEEVsDTssLQPQ
Q9H788	S159	Sugiyama	SH2D4A PPP1R38 SH2A	NQQtKDIWKKVAEKEELEQGsRPAPTLEEEKIRSLSSSSRN
Q9NR28	S230	Sugiyama	DIABLO SMAC	EAQIEELRQKTQEEGEERAEsEQEAyLRED___________
Q9NR30	S189	Sugiyama	DDX21	EEsNsEIEQEIPVEQKEGAFsNFPIsEEtIKLLKGRGVTFL
Q9NTJ3	T44	Sugiyama	SMC4 CAPC SMC4L1	DGAssDAEPEPPsGRtEsPAtAAEtAsEELDNRSLEEILNS
Q9NUQ3	S97	Sugiyama	TXLNG CXorf15 ELRG LSR5	KHSLEEDEGsDFItENRNLVsPAyCtQEsREEIPGGEARTD
Q9NYM9	S9	Sugiyama	BET1L GS15	____________MADWARAQsPGAVEEILDRENKRMADSLA
Q9UBP6	S27	Sugiyama	METTL1 C12orf1	NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UPQ0	S192	Sugiyama	LIMCH1 KIAA1102	RSIRDsGyIDCWDsERsDsLsPPRHGRDDsFDsLDsFGsRs
Q9UQ35	S1099	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sHsEsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRG
Q9UQ35	S1101	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sEsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEF
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	S2398	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ANLtsPRVPLsAyERVsGRtsPPLLDRARsRtPPsAPsQsR
Q9Y230	S43	Sugiyama	RUVBL2 INO80J TIP48 TIP49B CGI-46	GAHSHIRGLGLDDALEPRQAsQGMVGQLAARRAAGVVLEMI
Q9Y5K6	S458	Sugiyama	CD2AP	ETEPVSKLKLDsEQLPLRPKsVDFDsLtVRtsKEtDVVNFD

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Chromatin organization	R-HSA-4839726	2.174208e-08	7.663
Chromatin modifying enzymes	R-HSA-3247509	1.861319e-07	6.730
NRAGE signals death through JNK	R-HSA-193648	2.334132e-06	5.632
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	7.867282e-05	4.104
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	2.012786e-04	3.696
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	2.404155e-04	3.619
PKMTs methylate histone lysines	R-HSA-3214841	2.453611e-04	3.610
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.944979e-04	3.306
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.944979e-04	3.306
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.944979e-04	3.306
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	5.352613e-04	3.271
Regulation of PTEN gene transcription	R-HSA-8943724	4.517968e-04	3.345
p75 NTR receptor-mediated signalling	R-HSA-193704	3.949052e-04	3.404
Death Receptor Signaling	R-HSA-73887	5.056501e-04	3.296
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	6.729764e-04	3.172
Regulation of TP53 Expression	R-HSA-6804754	9.346194e-04	3.029
Circadian clock	R-HSA-9909396	1.420262e-03	2.848
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.592367e-03	2.798
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.713732e-03	2.766
ATP-dependent chromatin remodelers	R-HSA-9932444	2.001394e-03	2.699
SWI/SNF chromatin remodelers	R-HSA-9932451	2.001394e-03	2.699
Signaling by NTRKs	R-HSA-166520	2.058815e-03	2.686
Adipogenesis	R-HSA-9843745	2.509935e-03	2.600
Formation of axial mesoderm	R-HSA-9796292	2.470930e-03	2.607
G alpha (12/13) signalling events	R-HSA-416482	2.509583e-03	2.600
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.655154e-03	2.576
Oncogenic MAPK signaling	R-HSA-6802957	2.657462e-03	2.576
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.870600e-03	2.542
Kinesins	R-HSA-983189	2.912766e-03	2.536
Regulation of TP53 Activity	R-HSA-5633007	3.105611e-03	2.508
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	4.091355e-03	2.388
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	4.515235e-03	2.345
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	4.504706e-03	2.346
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	5.674363e-03	2.246
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	5.674363e-03	2.246
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	5.633300e-03	2.249
Apoptotic execution phase	R-HSA-75153	5.706461e-03	2.244
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	5.934270e-03	2.227
Epigenetic regulation of gene expression	R-HSA-212165	6.921737e-03	2.160
Repression of WNT target genes	R-HSA-4641265	7.627741e-03	2.118
NGF-stimulated transcription	R-HSA-9031628	7.593693e-03	2.120
Signaling by LTK	R-HSA-9842663	7.627741e-03	2.118
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	8.063533e-03	2.093
Signal Transduction	R-HSA-162582	9.082347e-03	2.042
Transport of the SLBP independent Mature mRNA	R-HSA-159227	9.528237e-03	2.021
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	9.528237e-03	2.021
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	9.528237e-03	2.021
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	9.224302e-03	2.035
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.006192e-02	1.997
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.076499e-02	1.968
Nuclear Envelope Breakdown	R-HSA-2980766	1.056258e-02	1.976
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.076499e-02	1.968
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.093543e-02	1.961
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.232316e-02	1.909
Polo-like kinase mediated events	R-HSA-156711	1.204371e-02	1.919
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.300256e-02	1.886
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.263650e-02	1.898
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.299756e-02	1.886
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.396573e-02	1.855
Transcriptional regulation by RUNX1	R-HSA-8878171	1.444711e-02	1.840
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.520461e-02	1.818
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.561709e-02	1.806
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	1.589628e-02	1.799
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.703062e-02	1.769
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.794625e-02	1.746
G1/S-Specific Transcription	R-HSA-69205	1.756511e-02	1.755
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.826254e-02	1.738
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.826254e-02	1.738
Signaling by NOTCH1	R-HSA-1980143	1.884115e-02	1.725
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.895288e-02	1.722
Deubiquitination	R-HSA-5688426	1.911669e-02	1.719
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.018526e-02	1.695
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.144689e-02	1.669
Gastrulation	R-HSA-9758941	2.136567e-02	1.670
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.121927e-02	1.673
Activation of RAC1	R-HSA-428540	2.247705e-02	1.648
Nuclear Receptor transcription pathway	R-HSA-383280	2.275148e-02	1.643
IPs transport between nucleus and cytosol	R-HSA-1855170	2.450517e-02	1.611
Transcriptional regulation by RUNX3	R-HSA-8878159	2.327767e-02	1.633
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.450517e-02	1.611
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.604903e-02	1.584
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.626300e-02	1.581
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.532299e-02	1.596
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.626300e-02	1.581
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	2.632057e-02	1.580
HATs acetylate histones	R-HSA-3214847	2.729411e-02	1.564
Cell Cycle	R-HSA-1640170	2.784237e-02	1.555
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.854685e-02	1.544
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.854685e-02	1.544
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.974838e-02	1.527
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.813720e-02	1.551
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	3.017765e-02	1.520
Mitotic Prophase	R-HSA-68875	3.031944e-02	1.518
Notch-HLH transcription pathway	R-HSA-350054	3.079360e-02	1.512
RAF activation	R-HSA-5673000	3.213126e-02	1.493
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.354879e-02	1.474
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.433985e-02	1.464
Nuclear import of Rev protein	R-HSA-180746	3.213126e-02	1.493
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	3.556321e-02	1.449
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.683620e-02	1.434
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	4.049233e-02	1.393
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	4.049233e-02	1.393
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	4.049233e-02	1.393
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	4.049233e-02	1.393
Signaling by TCF7L2 mutants	R-HSA-5339700	4.049233e-02	1.393
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	3.873792e-02	1.412
RET signaling	R-HSA-8853659	4.126296e-02	1.384
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	4.232064e-02	1.373
Regulation of signaling by CBL	R-HSA-912631	4.367030e-02	1.360
Specification of the neural plate border	R-HSA-9834899	4.367030e-02	1.360
Regulation of CDH19 Expression and Function	R-HSA-9764302	5.361833e-02	1.271
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.361833e-02	1.271
Signal attenuation	R-HSA-74749	5.015203e-02	1.300
Erythropoietin activates RAS	R-HSA-9027284	5.254090e-02	1.280
G0 and Early G1	R-HSA-1538133	5.091530e-02	1.293
TGFBR3 expression	R-HSA-9839394	4.838928e-02	1.315
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	5.200088e-02	1.284
HDMs demethylate histones	R-HSA-3214842	4.838928e-02	1.315
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.361833e-02	1.271
Cell Cycle, Mitotic	R-HSA-69278	5.295992e-02	1.276
Apoptosis induced DNA fragmentation	R-HSA-140342	5.015203e-02	1.300
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	5.015203e-02	1.300
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.015203e-02	1.300
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	5.200088e-02	1.284
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.376513e-02	1.269
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	5.663264e-02	1.247
Nuclear RNA decay	R-HSA-9930044	5.741604e-02	1.241
Loss of Function of TP53 in Cancer	R-HSA-9723907	9.991237e-02	1.000
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.991237e-02	1.000
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	9.991237e-02	1.000
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	9.991237e-02	1.000
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	9.991237e-02	1.000
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	6.726072e-02	1.172
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	6.726072e-02	1.172
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	6.726072e-02	1.172
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	6.726072e-02	1.172
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	6.726072e-02	1.172
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	6.726072e-02	1.172
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	6.726072e-02	1.172
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	6.726072e-02	1.172
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	6.726072e-02	1.172
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	6.726072e-02	1.172
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	6.726072e-02	1.172
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.898476e-01	0.722
Diseases of Telomere Maintenance	R-HSA-9673013	1.898476e-01	0.722
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.898476e-01	0.722
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.898476e-01	0.722
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	R-HSA-9036092	1.898476e-01	0.722
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.898476e-01	0.722
MET interacts with TNS proteins	R-HSA-8875513	9.825899e-02	1.008
Invadopodia formation	R-HSA-8941237	9.825899e-02	1.008
HCN channels	R-HSA-1296061	1.323757e-01	0.878
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.323757e-01	0.878
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.323757e-01	0.878
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.323757e-01	0.878
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	1.323757e-01	0.878
Signaling by MAP2K mutants	R-HSA-9652169	1.323757e-01	0.878
NFG and proNGF binds to p75NTR	R-HSA-205017	2.708013e-01	0.567
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.708013e-01	0.567
Defective VWF binding to collagen type I	R-HSA-9845622	2.708013e-01	0.567
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.708013e-01	0.567
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.708013e-01	0.567
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.708013e-01	0.567
PTEN Loss of Function in Cancer	R-HSA-5674404	2.708013e-01	0.567
RUNX3 regulates WNT signaling	R-HSA-8951430	9.016944e-02	1.045
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	9.016944e-02	1.045
Regulation of PTEN localization	R-HSA-8948747	9.016944e-02	1.045
NOSTRIN mediated eNOS trafficking	R-HSA-203641	9.016944e-02	1.045
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	9.016944e-02	1.045
SMAC (DIABLO) binds to IAPs	R-HSA-111463	1.686792e-01	0.773
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.686792e-01	0.773
IRS activation	R-HSA-74713	1.686792e-01	0.773
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	1.686792e-01	0.773
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.686792e-01	0.773
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	1.686792e-01	0.773
Signaling by MRAS-complex mutants	R-HSA-9660537	1.114445e-01	0.953
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.114445e-01	0.953
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.584243e-02	1.120
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	7.584243e-02	1.120
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.252572e-02	1.204
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	9.073743e-02	1.042
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	9.073743e-02	1.042
SHC-related events triggered by IGF1R	R-HSA-2428933	9.073743e-02	1.042
GP1b-IX-V activation signalling	R-HSA-430116	1.344182e-01	0.872
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.063925e-01	0.685
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.063925e-01	0.685
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	2.063925e-01	0.685
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	2.063925e-01	0.685
Signaling by RNF43 mutants	R-HSA-5340588	2.063925e-01	0.685
Regulation of cortical dendrite branching	R-HSA-8985801	3.436702e-01	0.464
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.436702e-01	0.464
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	3.436702e-01	0.464
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	3.436702e-01	0.464
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.436702e-01	0.464
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.436702e-01	0.464
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.436702e-01	0.464
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.436702e-01	0.464
MET activates RAP1 and RAC1	R-HSA-8875555	1.588525e-01	0.799
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.242838e-01	0.906
Activated NTRK3 signals through RAS	R-HSA-9034864	1.845086e-01	0.734
Interleukin receptor SHC signaling	R-HSA-912526	8.912394e-02	1.050
Differentiation of T cells	R-HSA-9945266	1.622353e-01	0.790
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	1.622353e-01	0.790
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.111525e-01	0.675
Activated NTRK2 signals through RAS	R-HSA-9026519	2.111525e-01	0.675
Signaling by AXIN mutants	R-HSA-4839735	2.111525e-01	0.675
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	2.835885e-01	0.547
PTK6 Expression	R-HSA-8849473	2.835885e-01	0.547
SOS-mediated signalling	R-HSA-112412	2.835885e-01	0.547
Activation of BIM and translocation to mitochondria	R-HSA-111446	4.092611e-01	0.388
Axonal growth stimulation	R-HSA-209563	4.092611e-01	0.388
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	4.092611e-01	0.388
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.092611e-01	0.388
Defective MMACHC causes MAHCC	R-HSA-3359474	4.092611e-01	0.388
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.092611e-01	0.388
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	4.092611e-01	0.388
Defective GSS causes GSS deficiency	R-HSA-5579006	4.092611e-01	0.388
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.092611e-01	0.388
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.424556e-01	0.846
p75NTR recruits signalling complexes	R-HSA-209543	2.385595e-01	0.622
RUNX3 regulates p14-ARF	R-HSA-8951936	2.385595e-01	0.622
Signaling downstream of RAS mutants	R-HSA-9649948	6.356373e-02	1.197
Type I hemidesmosome assembly	R-HSA-446107	3.221107e-01	0.492
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	3.221107e-01	0.492
MET receptor recycling	R-HSA-8875656	3.221107e-01	0.492
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.221107e-01	0.492
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.665172e-01	0.574
HDACs deacetylate histones	R-HSA-3214815	7.403222e-02	1.131
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.255860e-01	0.647
TRAF6 mediated NF-kB activation	R-HSA-933542	2.117733e-01	0.674
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.600912e-01	0.444
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	3.600912e-01	0.444
Regulated proteolysis of p75NTR	R-HSA-193692	3.600912e-01	0.444
Inactivation of CDC42 and RAC1	R-HSA-428543	3.600912e-01	0.444
ALK mutants bind TKIs	R-HSA-9700645	3.600912e-01	0.444
NADE modulates death signalling	R-HSA-205025	4.683006e-01	0.329
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.683006e-01	0.329
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.683006e-01	0.329
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.683006e-01	0.329
Signaling by LRP5 mutants	R-HSA-5339717	4.683006e-01	0.329
Defective LFNG causes SCDO3	R-HSA-5083630	4.683006e-01	0.329
Signaling by RAF1 mutants	R-HSA-9656223	1.500459e-01	0.824
RNA Polymerase II Transcription Termination	R-HSA-73856	1.177661e-01	0.929
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.972537e-01	0.401
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.637645e-01	0.786
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.694739e-01	0.569
mRNA 3'-end processing	R-HSA-72187	1.866422e-01	0.729
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	3.517896e-01	0.454
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.854329e-01	0.732
MAP2K and MAPK activation	R-HSA-5674135	2.610321e-01	0.583
Signaling by Erythropoietin	R-HSA-9006335	3.096458e-01	0.509
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.409474e-01	0.467
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	3.801258e-01	0.420
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.801258e-01	0.420
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	4.333826e-01	0.363
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	4.333826e-01	0.363
Signaling by APC mutants	R-HSA-4839744	4.333826e-01	0.363
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.333826e-01	0.363
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.333826e-01	0.363
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.333826e-01	0.363
NOSIP mediated eNOS trafficking	R-HSA-203754	5.214427e-01	0.283
FLT3 signaling by CBL mutants	R-HSA-9706377	5.214427e-01	0.283
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.214427e-01	0.283
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.214427e-01	0.283
Activation of the pre-replicative complex	R-HSA-68962	3.300423e-01	0.481
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.300423e-01	0.481
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.979722e-01	0.703
Amplification of signal from the kinetochores	R-HSA-141424	1.979722e-01	0.703
AURKA Activation by TPX2	R-HSA-8854518	2.572563e-01	0.590
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.881063e-01	0.411
Deadenylation of mRNA	R-HSA-429947	3.881063e-01	0.411
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.683135e-01	0.329
Signaling by GSK3beta mutants	R-HSA-5339716	4.683135e-01	0.329
Diseases of mitotic cell cycle	R-HSA-9675126	3.711387e-01	0.430
RNA Polymerase III Transcription Termination	R-HSA-73980	4.358406e-01	0.361
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	3.747645e-01	0.426
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.342305e-01	0.476
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.342305e-01	0.476
mRNA Splicing	R-HSA-72172	2.045803e-01	0.689
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	5.019249e-01	0.299
IRAK1 recruits IKK complex	R-HSA-937039	5.019249e-01	0.299
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.019249e-01	0.299
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	5.019249e-01	0.299
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	5.019249e-01	0.299
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	5.019249e-01	0.299
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	5.019249e-01	0.299
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	5.019249e-01	0.299
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.692763e-01	0.245
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.692763e-01	0.245
PKB-mediated events	R-HSA-109703	5.692763e-01	0.245
PDE3B signalling	R-HSA-165160	5.692763e-01	0.245
IkBA variant leads to EDA-ID	R-HSA-5603029	5.692763e-01	0.245
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.692763e-01	0.245
Noncanonical activation of NOTCH3	R-HSA-9017802	5.692763e-01	0.245
Signaling by MAPK mutants	R-HSA-9652817	5.692763e-01	0.245
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	4.117360e-01	0.385
HIV Transcription Initiation	R-HSA-167161	4.117360e-01	0.385
RNA Polymerase II Transcription Initiation	R-HSA-75953	4.117360e-01	0.385
PPARA activates gene expression	R-HSA-1989781	2.854335e-01	0.544
HSF1-dependent transactivation	R-HSA-3371571	4.275025e-01	0.369
RNA Polymerase II Promoter Escape	R-HSA-73776	4.484764e-01	0.348
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.341318e-01	0.272
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.341318e-01	0.272
mRNA Splicing - Major Pathway	R-HSA-72163	3.192569e-01	0.496
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	4.729905e-01	0.325
SHC-mediated cascade:FGFR3	R-HSA-5654704	5.154808e-01	0.288
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.154808e-01	0.288
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.026781e-01	0.299
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.026781e-01	0.299
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	4.846950e-01	0.315
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.846950e-01	0.315
Nucleosome assembly	R-HSA-774815	4.846950e-01	0.315
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.806564e-01	0.318
Condensation of Prophase Chromosomes	R-HSA-2299718	5.025270e-01	0.299
mRNA Splicing - Minor Pathway	R-HSA-72165	5.025270e-01	0.299
Signaling by ERBB2 in Cancer	R-HSA-1227990	5.245162e-01	0.280
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	5.245162e-01	0.280
SHC-mediated cascade:FGFR4	R-HSA-5654719	5.406679e-01	0.267
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	5.406679e-01	0.267
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	6.123312e-01	0.213
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.123312e-01	0.213
Erythropoietin activates STAT5	R-HSA-9027283	6.123312e-01	0.213
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	6.123312e-01	0.213
Centrosome maturation	R-HSA-380287	5.094246e-01	0.293
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	5.650825e-01	0.248
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	5.941371e-01	0.226
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.941371e-01	0.226
Beta-catenin phosphorylation cascade	R-HSA-196299	5.941371e-01	0.226
SHC1 events in EGFR signaling	R-HSA-180336	5.941371e-01	0.226
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.941371e-01	0.226
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	5.653300e-01	0.248
Regulation of PTEN mRNA translation	R-HSA-8943723	5.886855e-01	0.230
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	5.685253e-01	0.245
SHC-mediated cascade:FGFR1	R-HSA-5654688	6.114476e-01	0.214
Phosphorylation of the APC/C	R-HSA-176412	6.218960e-01	0.206
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.186537e-01	0.209
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	6.197487e-01	0.208
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	6.333482e-01	0.198
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	1.913672e-01	0.718
PTEN Regulation	R-HSA-6807070	7.134244e-02	1.147
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	1.637645e-01	0.786
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.078523e-01	0.682
Transcription of the HIV genome	R-HSA-167172	5.473347e-01	0.262
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	3.028493e-01	0.519
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.368479e-01	0.360
Signaling by NOTCH3	R-HSA-9012852	3.464348e-01	0.460
Regulation of endogenous retroelements	R-HSA-9842860	2.178422e-01	0.662
FOXO-mediated transcription	R-HSA-9614085	1.905615e-01	0.720
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	2.299168e-01	0.638
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	2.299168e-01	0.638
Formation of definitive endoderm	R-HSA-9823730	1.269155e-01	0.896
Insulin receptor signalling cascade	R-HSA-74751	4.870487e-01	0.312
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	1.069122e-01	0.971
Signaling by ERBB2	R-HSA-1227986	4.248155e-01	0.372
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.966965e-02	1.047
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	2.284026e-01	0.641
Regulation of CDH11 function	R-HSA-9762292	1.588525e-01	0.799
VxPx cargo-targeting to cilium	R-HSA-5620916	1.269155e-01	0.896
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.881063e-01	0.411
Cellular response to heat stress	R-HSA-3371556	1.284153e-01	0.891
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	2.284026e-01	0.641
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	2.284026e-01	0.641
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	9.073743e-02	1.042
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.517298e-01	0.454
IGF1R signaling cascade	R-HSA-2428924	2.322994e-01	0.634
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	4.117360e-01	0.385
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	6.259544e-01	0.203
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	6.356373e-02	1.197
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	6.356373e-02	1.197
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	2.948271e-01	0.530
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	2.694739e-01	0.569
Mitotic Spindle Checkpoint	R-HSA-69618	1.994675e-01	0.700
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	3.229998e-01	0.491
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	4.895708e-01	0.310
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	5.245162e-01	0.280
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	5.650825e-01	0.248
p75NTR signals via NF-kB	R-HSA-193639	3.233067e-01	0.490
TRAF6 mediated IRF7 activation	R-HSA-933541	4.928100e-01	0.307
Mitotic Anaphase	R-HSA-68882	3.578691e-01	0.446
Formation of the posterior neural plate	R-HSA-9832991	6.229641e-02	1.206
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.826061e-01	0.738
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	3.600912e-01	0.444
Regulation of the apoptosome activity	R-HSA-9627069	3.972537e-01	0.401
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	2.227258e-01	0.652
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.195837e-01	0.495
Cytochrome c-mediated apoptotic response	R-HSA-111461	4.683135e-01	0.329
IRS-related events triggered by IGF1R	R-HSA-2428928	5.890749e-01	0.230
Interleukin-15 signaling	R-HSA-8983432	9.073743e-02	1.042
DAP12 signaling	R-HSA-2424491	1.826745e-01	0.738
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.434106e-01	0.843
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.689383e-01	0.245
TRAF3-dependent IRF activation pathway	R-HSA-918233	7.350477e-02	1.134
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.659355e-01	0.437
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.104148e-01	0.957
Signaling by WNT in cancer	R-HSA-4791275	1.104148e-01	0.957
Signaling by Activin	R-HSA-1502540	3.233067e-01	0.490
Formation of apoptosome	R-HSA-111458	3.972537e-01	0.401
PI3K/AKT activation	R-HSA-198203	3.972537e-01	0.401
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.333826e-01	0.363
Transcriptional regulation by small RNAs	R-HSA-5578749	2.275278e-01	0.643
MET activates RAS signaling	R-HSA-8851805	5.019249e-01	0.299
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	4.577601e-01	0.339
RNA Polymerase III Transcription	R-HSA-74158	4.729905e-01	0.325
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	5.406679e-01	0.267
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.030663e-01	0.987
PIP3 activates AKT signaling	R-HSA-1257604	1.732429e-01	0.761
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	4.269951e-01	0.370
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.446645e-01	0.611
Neurexins and neuroligins	R-HSA-6794361	3.003074e-01	0.522
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.119126e-01	0.385
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	1.242838e-01	0.906
Signaling by RAS mutants	R-HSA-6802949	6.356373e-02	1.197
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.091114e-01	0.388
Resolution of D-Loop Structures	R-HSA-5693537	6.067966e-01	0.217
Negative regulation of MAPK pathway	R-HSA-5675221	2.610321e-01	0.583
Cyclin D associated events in G1	R-HSA-69231	4.666678e-01	0.331
G1 Phase	R-HSA-69236	4.666678e-01	0.331
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.950957e-01	0.305
Mitotic Prometaphase	R-HSA-68877	3.879028e-01	0.411
Hedgehog 'on' state	R-HSA-5632684	2.161763e-01	0.665
NTRK3 as a dependence receptor	R-HSA-9603505	2.708013e-01	0.567
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	1.114445e-01	0.953
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	9.073743e-02	1.042
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	7.350477e-02	1.134
Gap junction degradation	R-HSA-190873	3.600912e-01	0.444
Regulation of gap junction activity	R-HSA-191650	4.683006e-01	0.329
Regulation of TP53 Activity through Methylation	R-HSA-6804760	4.358406e-01	0.361
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	3.747645e-01	0.426
Ligand-receptor interactions	R-HSA-5632681	5.692763e-01	0.245
Signaling by MST1	R-HSA-8852405	5.692763e-01	0.245
DARPP-32 events	R-HSA-180024	5.026781e-01	0.299
RAF-independent MAPK1/3 activation	R-HSA-112409	5.650825e-01	0.248
TCF dependent signaling in response to WNT	R-HSA-201681	4.652060e-01	0.332
Transcriptional Regulation by TP53	R-HSA-3700989	2.641915e-01	0.578
Cardiogenesis	R-HSA-9733709	2.313360e-01	0.636
M Phase	R-HSA-68886	2.580993e-01	0.588
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.650825e-01	0.248
Laminin interactions	R-HSA-3000157	6.333482e-01	0.198
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.498313e-01	0.602
Activation of HOX genes during differentiation	R-HSA-5619507	4.481406e-01	0.349
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.481406e-01	0.349
Hedgehog 'off' state	R-HSA-5610787	3.878027e-01	0.411
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	7.127685e-02	1.147
Ovarian tumor domain proteases	R-HSA-5689896	9.751934e-02	1.011
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	8.725623e-02	1.059
Rap1 signalling	R-HSA-392517	2.479709e-01	0.606
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	4.326638e-01	0.364
RNA Polymerase I Transcription	R-HSA-73864	5.515937e-01	0.258
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	6.252572e-02	1.204
Processing of DNA double-strand break ends	R-HSA-5693607	3.382318e-01	0.471
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	8.912394e-02	1.050
RNA Polymerase I Promoter Clearance	R-HSA-73854	5.236272e-01	0.281
GPER1 signaling	R-HSA-9634597	5.374926e-01	0.270
G1/S DNA Damage Checkpoints	R-HSA-69615	6.186537e-01	0.209
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.974618e-02	1.001
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	5.583935e-01	0.253
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	5.581738e-01	0.253
Signaling by NOTCH	R-HSA-157118	5.543580e-01	0.256
Cargo trafficking to the periciliary membrane	R-HSA-5620920	3.229998e-01	0.491
Clathrin-mediated endocytosis	R-HSA-8856828	2.585304e-01	0.587
Prolonged ERK activation events	R-HSA-169893	6.252572e-02	1.204
Mitotic G1 phase and G1/S transition	R-HSA-453279	4.613752e-01	0.336
Cilium Assembly	R-HSA-5617833	4.435653e-01	0.353
Intracellular signaling by second messengers	R-HSA-9006925	2.317744e-01	0.635
Post-transcriptional silencing by small RNAs	R-HSA-426496	1.686792e-01	0.773
Calcineurin activates NFAT	R-HSA-2025928	1.344182e-01	0.872
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.424556e-01	0.846
Adrenoceptors	R-HSA-390696	3.221107e-01	0.492
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	6.333023e-02	1.198
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.096341e-01	0.960
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.096341e-01	0.960
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.096341e-01	0.960
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.096341e-01	0.960
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.619330e-01	0.791
Signaling by NODAL	R-HSA-1181150	2.708048e-01	0.567
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.858984e-01	0.731
MET promotes cell motility	R-HSA-8875878	2.001733e-01	0.699
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.801258e-01	0.420
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	5.154808e-01	0.288
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.648792e-01	0.248
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.870502e-01	0.231
Killing mechanisms	R-HSA-9664420	6.218960e-01	0.206
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.218960e-01	0.206
Signaling by TGFB family members	R-HSA-9006936	9.427912e-02	1.026
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	4.559292e-01	0.341
Late Phase of HIV Life Cycle	R-HSA-162599	3.301838e-01	0.481
Gene expression (Transcription)	R-HSA-74160	1.502945e-01	0.823
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.128168e-01	0.948
Cyclin E associated events during G1/S transition	R-HSA-69202	4.368479e-01	0.360
GPVI-mediated activation cascade	R-HSA-114604	4.729905e-01	0.325
Germ layer formation at gastrulation	R-HSA-9754189	2.479709e-01	0.606
RNA Polymerase II Transcription	R-HSA-73857	2.888577e-01	0.539
Cell Cycle Checkpoints	R-HSA-69620	1.637169e-01	0.786
Signaling by Hippo	R-HSA-2028269	8.546261e-02	1.068
Interleukin-2 signaling	R-HSA-9020558	4.333826e-01	0.363
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	4.661236e-01	0.331
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.111525e-01	0.675
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.019249e-01	0.299
DNA Double Strand Break Response	R-HSA-5693606	5.325123e-01	0.274
Signaling by Hedgehog	R-HSA-5358351	3.700415e-01	0.432
MTOR signalling	R-HSA-165159	2.770186e-01	0.557
Signaling by EGFR	R-HSA-177929	3.620317e-01	0.441
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	2.498313e-01	0.602
Homology Directed Repair	R-HSA-5693538	4.183155e-01	0.378
S Phase	R-HSA-69242	5.778103e-01	0.238
Generic Transcription Pathway	R-HSA-212436	3.109352e-01	0.507
Transcriptional Regulation by VENTX	R-HSA-8853884	1.385995e-01	0.858
DNA Double-Strand Break Repair	R-HSA-5693532	2.683804e-01	0.571
Protein-protein interactions at synapses	R-HSA-6794362	3.905263e-01	0.408
Organelle biogenesis and maintenance	R-HSA-1852241	2.100377e-01	0.678
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.852238e-02	1.105
Inhibition of nitric oxide production	R-HSA-9636249	4.092611e-01	0.388
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.498313e-01	0.602
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.214427e-01	0.283
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	4.683135e-01	0.329
Oxidative Stress Induced Senescence	R-HSA-2559580	2.178422e-01	0.662
Ub-specific processing proteases	R-HSA-5689880	2.256061e-01	0.647
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.978968e-01	0.400
Signalling to RAS	R-HSA-167044	5.154808e-01	0.288
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	6.123312e-01	0.213
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.432554e-01	0.844
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.641679e-01	0.439
Signalling to ERKs	R-HSA-187687	7.995095e-02	1.097
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.067966e-01	0.217
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	5.545752e-01	0.256
p53-Dependent G1 DNA Damage Response	R-HSA-69563	5.545752e-01	0.256
Cellular Senescence	R-HSA-2559583	1.579668e-01	0.801
Activation of BH3-only proteins	R-HSA-114452	1.826745e-01	0.738
Oncogene Induced Senescence	R-HSA-2559585	4.529277e-01	0.344
Estrogen-dependent gene expression	R-HSA-9018519	4.444797e-01	0.352
MAPK family signaling cascades	R-HSA-5683057	4.981034e-01	0.303
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.686792e-01	0.773
Neurofascin interactions	R-HSA-447043	2.448720e-01	0.611
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.448720e-01	0.611
Vasopressin-like receptors	R-HSA-388479	4.683006e-01	0.329
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.708048e-01	0.567
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.854329e-01	0.732
Intrinsic Pathway for Apoptosis	R-HSA-109606	2.369591e-01	0.625
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.941371e-01	0.226
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.941371e-01	0.226
Signaling by TGFBR3	R-HSA-9839373	6.356373e-02	1.197
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.259544e-01	0.203
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	4.295164e-01	0.367
Signaling by VEGF	R-HSA-194138	2.284026e-01	0.641
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.881063e-01	0.411
Interleukin-2 family signaling	R-HSA-451927	2.299168e-01	0.638
G1/S Transition	R-HSA-69206	3.102818e-01	0.508
Frs2-mediated activation	R-HSA-170968	1.069122e-01	0.971
Sema4D in semaphorin signaling	R-HSA-400685	1.125243e-01	0.949
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	4.295164e-01	0.367
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.630883e-01	0.334
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	5.374926e-01	0.270
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	5.958021e-02	1.225
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.630883e-01	0.334
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.411182e-01	0.850
Regulation of CDH1 Gene Transcription	R-HSA-9764560	7.396340e-02	1.131
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.972785e-01	0.303
SDK interactions	R-HSA-373756	1.898476e-01	0.722
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.708013e-01	0.567
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.686792e-01	0.773
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	1.344182e-01	0.872
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.344182e-01	0.872
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	3.436702e-01	0.464
TGFBR3 regulates activin signaling	R-HSA-9839406	3.436702e-01	0.464
Regulation of KIT signaling	R-HSA-1433559	1.242838e-01	0.906
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	2.448720e-01	0.611
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	9.837415e-02	1.007
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	2.835885e-01	0.547
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	3.221107e-01	0.492
Formation of annular gap junctions	R-HSA-196025	3.221107e-01	0.492
Regulation of MECP2 expression and activity	R-HSA-9022692	1.216620e-01	0.915
PI5P Regulates TP53 Acetylation	R-HSA-6811555	2.665172e-01	0.574
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.120973e-01	0.950
Unwinding of DNA	R-HSA-176974	3.600912e-01	0.444
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.683006e-01	0.329
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.483957e-01	0.605
Metabolism of non-coding RNA	R-HSA-194441	1.744402e-01	0.758
snRNP Assembly	R-HSA-191859	1.744402e-01	0.758
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	2.894344e-01	0.538
mTORC1-mediated signalling	R-HSA-166208	3.409474e-01	0.467
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.214427e-01	0.283
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.214427e-01	0.283
Mitochondrial biogenesis	R-HSA-1592230	1.572133e-01	0.804
Regulation of FZD by ubiquitination	R-HSA-4641263	4.081820e-01	0.389
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.683135e-01	0.329
NF-kB is activated and signals survival	R-HSA-209560	4.683135e-01	0.329
Signaling by AMER1 mutants	R-HSA-4839748	4.683135e-01	0.329
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	4.358406e-01	0.361
PKA activation in glucagon signalling	R-HSA-164378	4.358406e-01	0.361
Metalloprotease DUBs	R-HSA-5689901	4.347841e-01	0.362
Pentose phosphate pathway disease	R-HSA-6791465	5.692763e-01	0.245
Ceramide signalling	R-HSA-193681	5.692763e-01	0.245
Sensory perception of salty taste	R-HSA-9730628	5.692763e-01	0.245
Synthesis of PS	R-HSA-1483101	5.692763e-01	0.245
G2/M DNA replication checkpoint	R-HSA-69478	6.123312e-01	0.213
G2/M Checkpoints	R-HSA-69481	5.293292e-01	0.276
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.941371e-01	0.226
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.259544e-01	0.203
Cell junction organization	R-HSA-446728	4.789108e-01	0.320
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.096341e-01	0.960
G2/M Transition	R-HSA-69275	2.564786e-01	0.591
Adherens junctions interactions	R-HSA-418990	6.112384e-01	0.214
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	7.724712e-02	1.112
Signaling by PTK6	R-HSA-8848021	7.724712e-02	1.112
Signaling by MET	R-HSA-6806834	3.253517e-01	0.488
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.333387e-02	1.030
Mitotic G2-G2/M phases	R-HSA-453274	2.716994e-01	0.566
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.978968e-01	0.400
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.972537e-01	0.401
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.637763e-01	0.579
Regulation of TP53 Expression and Degradation	R-HSA-6806003	5.315689e-01	0.274
Nervous system development	R-HSA-9675108	5.923717e-01	0.227
Signaling by NOTCH2	R-HSA-1980145	4.326638e-01	0.364
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.883158e-01	0.411
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.637763e-01	0.579
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.637763e-01	0.579
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.863281e-01	0.413
DNA Repair	R-HSA-73894	5.853695e-01	0.233
Activation of ATR in response to replication stress	R-HSA-176187	1.216620e-01	0.915
HIV Life Cycle	R-HSA-162587	3.864549e-01	0.413
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.560940e-01	0.341
Axon guidance	R-HSA-422475	6.006021e-01	0.221
Cell-Cell communication	R-HSA-1500931	4.801621e-01	0.319
Downstream signal transduction	R-HSA-186763	9.974618e-02	1.001
RUNX2 regulates bone development	R-HSA-8941326	1.720627e-01	0.764
TNF signaling	R-HSA-75893	1.434106e-01	0.843
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.852238e-02	1.105
tRNA processing in the nucleus	R-HSA-6784531	1.262291e-01	0.899
TBC/RABGAPs	R-HSA-8854214	2.932443e-01	0.533
Formation of the ureteric bud	R-HSA-9830674	5.886855e-01	0.230
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.318409e-01	0.199
DAP12 interactions	R-HSA-2172127	4.666678e-01	0.331
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	7.360547e-02	1.133
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.737010e-01	0.427
DCC mediated attractive signaling	R-HSA-418885	1.427588e-01	0.845
Negative regulation of FLT3	R-HSA-9706369	3.517896e-01	0.454
Signaling by PDGFR in disease	R-HSA-9671555	3.173940e-01	0.498
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.773678e-01	0.423
Evasion by RSV of host interferon responses	R-HSA-9833109	5.458813e-01	0.263
Regulation of TNFR1 signaling	R-HSA-5357905	2.134970e-01	0.671
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.443309e-01	0.352
Membrane Trafficking	R-HSA-199991	3.479136e-01	0.459
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	2.932443e-01	0.533
RMTs methylate histone arginines	R-HSA-3214858	3.096741e-01	0.509
Activation of PUMA and translocation to mitochondria	R-HSA-139915	9.016944e-02	1.045
Cell-extracellular matrix interactions	R-HSA-446353	1.427588e-01	0.845
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	3.221107e-01	0.492
Heme signaling	R-HSA-9707616	7.133005e-02	1.147
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.683006e-01	0.329
Rab regulation of trafficking	R-HSA-9007101	4.071244e-01	0.390
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	6.280070e-02	1.202
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.000466e-01	0.699
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	5.154808e-01	0.288
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	5.154808e-01	0.288
Signaling by EGFRvIII in Cancer	R-HSA-5637812	4.081820e-01	0.389
Constitutive Signaling by EGFRvIII	R-HSA-5637810	4.081820e-01	0.389
NOD1/2 Signaling Pathway	R-HSA-168638	4.326638e-01	0.364
Displacement of DNA glycosylase by APEX1	R-HSA-110357	9.016944e-02	1.045
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	2.835885e-01	0.547
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.387092e-01	0.858
MAP kinase activation	R-HSA-450294	3.055626e-01	0.515
Apoptosis	R-HSA-109581	2.694449e-01	0.570
Interleukin-17 signaling	R-HSA-448424	3.095402e-01	0.509
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.262726e-01	0.486
L1CAM interactions	R-HSA-373760	6.104409e-01	0.214
Signaling by NTRK3 (TRKC)	R-HSA-9034015	3.173940e-01	0.498
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.117733e-01	0.674
Neurodegenerative Diseases	R-HSA-8863678	2.117733e-01	0.674
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	2.083161e-01	0.681
Regulation of NPAS4 gene expression	R-HSA-9768759	4.081820e-01	0.389
Signal transduction by L1	R-HSA-445144	4.895708e-01	0.310
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	4.206506e-01	0.376
Tie2 Signaling	R-HSA-210993	2.255860e-01	0.647
Recycling pathway of L1	R-HSA-437239	5.201351e-01	0.284
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	5.197473e-01	0.284
Zygotic genome activation (ZGA)	R-HSA-9819196	5.958021e-02	1.225
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	6.867209e-02	1.163
Gene Silencing by RNA	R-HSA-211000	4.841790e-01	0.315
FLT3 Signaling	R-HSA-9607240	1.385995e-01	0.858
Interleukin-1 family signaling	R-HSA-446652	6.164411e-01	0.210
MyD88-independent TLR4 cascade	R-HSA-166166	5.197473e-01	0.284
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.216620e-01	0.915
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	4.601888e-01	0.337
Breakdown of the nuclear lamina	R-HSA-352238	2.708013e-01	0.567
Formation of the anterior neural plate	R-HSA-9823739	1.427588e-01	0.845
Activation of SMO	R-HSA-5635838	1.622353e-01	0.790
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	7.193013e-02	1.143
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.216620e-01	0.915
Transcriptional Regulation by E2F6	R-HSA-8953750	1.170925e-01	0.931
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.255860e-01	0.647
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.948271e-01	0.530
Retrograde neurotrophin signalling	R-HSA-177504	2.948271e-01	0.530
Sensory perception of sour taste	R-HSA-9729555	4.683006e-01	0.329
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	4.683006e-01	0.329
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	2.939803e-01	0.532
Disorders of Developmental Biology	R-HSA-9675151	3.801258e-01	0.420
Activation of AKT2	R-HSA-165158	5.214427e-01	0.283
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	3.881063e-01	0.411
Viral Messenger RNA Synthesis	R-HSA-168325	3.055626e-01	0.515
Golgi-to-ER retrograde transport	R-HSA-8856688	2.227610e-01	0.652
Integrin signaling	R-HSA-354192	3.917185e-01	0.407
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	5.019249e-01	0.299
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	5.019249e-01	0.299
G2/M DNA damage checkpoint	R-HSA-69473	4.950957e-01	0.305
Programmed Cell Death	R-HSA-5357801	4.201480e-01	0.377
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.096458e-01	0.509
FLT3 signaling in disease	R-HSA-9682385	3.014387e-01	0.521
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.114445e-01	0.953
Collagen degradation	R-HSA-1442490	5.890749e-01	0.230
Regulation of CDH11 gene transcription	R-HSA-9762293	1.344182e-01	0.872
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.448720e-01	0.611
Interleukin-37 signaling	R-HSA-9008059	8.966965e-02	1.047
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.113936e-01	0.953
Myogenesis	R-HSA-525793	2.498313e-01	0.602
ERK/MAPK targets	R-HSA-198753	5.154808e-01	0.288
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.941371e-01	0.226
Regulation of necroptotic cell death	R-HSA-5675482	5.870502e-01	0.231
MITF-M-regulated melanocyte development	R-HSA-9730414	2.059853e-01	0.686
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	3.233067e-01	0.490
Signaling by PDGF	R-HSA-186797	3.198311e-01	0.495
Signaling by SCF-KIT	R-HSA-1433557	2.932443e-01	0.533
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	1.622353e-01	0.790
MECP2 regulates transcription factors	R-HSA-9022707	2.835885e-01	0.547
The NLRP1 inflammasome	R-HSA-844455	4.092611e-01	0.388
Interactions of Rev with host cellular proteins	R-HSA-177243	6.442044e-02	1.191
Uptake and function of anthrax toxins	R-HSA-5210891	2.037604e-01	0.691
Dopamine receptors	R-HSA-390651	4.683006e-01	0.329
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	5.214427e-01	0.283
NrCAM interactions	R-HSA-447038	5.214427e-01	0.283
Collagen chain trimerization	R-HSA-8948216	3.195837e-01	0.495
Anchoring fibril formation	R-HSA-2214320	4.683135e-01	0.329
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	4.347841e-01	0.362
Relaxin receptors	R-HSA-444821	5.692763e-01	0.245
CREB phosphorylation	R-HSA-199920	6.123312e-01	0.213
NADPH regeneration	R-HSA-389542	6.123312e-01	0.213
Signaling by LTK in cancer	R-HSA-9842640	6.123312e-01	0.213
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.886855e-01	0.230
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	6.158360e-01	0.211
MITF-M-dependent gene expression	R-HSA-9856651	8.674798e-02	1.062
PI Metabolism	R-HSA-1483255	3.069552e-01	0.513
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.763837e-01	0.239
Nephrin family interactions	R-HSA-373753	2.708048e-01	0.567
Pexophagy	R-HSA-9664873	3.972537e-01	0.401
Sensory processing of sound	R-HSA-9659379	2.120438e-01	0.674
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.747960e-01	0.426
Transcriptional Regulation by MECP2	R-HSA-8986944	1.130617e-01	0.947
Semaphorin interactions	R-HSA-373755	6.186537e-01	0.209
Signaling by ALK in cancer	R-HSA-9700206	3.747960e-01	0.426
Specification of primordial germ cells	R-HSA-9827857	2.037604e-01	0.691
Netrin-1 signaling	R-HSA-373752	4.666678e-01	0.331
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.686792e-01	0.773
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.221107e-01	0.492
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.215525e-01	0.915
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.600912e-01	0.444
DNA Damage Recognition in GG-NER	R-HSA-5696394	4.122444e-01	0.385
OAS antiviral response	R-HSA-8983711	5.019249e-01	0.299
Pervasive developmental disorders	R-HSA-9005895	5.019249e-01	0.299
Disorders of Nervous System Development	R-HSA-9697154	5.019249e-01	0.299
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.019249e-01	0.299
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	5.692763e-01	0.245
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.692763e-01	0.245
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	5.692763e-01	0.245
Release of Hh-Np from the secreting cell	R-HSA-5362798	5.692763e-01	0.245
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	5.692763e-01	0.245
Syndecan interactions	R-HSA-3000170	5.886855e-01	0.230
PKR-mediated signaling	R-HSA-9833482	5.788847e-01	0.237
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.045781e-01	0.981
Inositol phosphate metabolism	R-HSA-1483249	2.403594e-01	0.619
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.329973e-01	0.199
CREB3 factors activate genes	R-HSA-8874211	6.123312e-01	0.213
ISG15 antiviral mechanism	R-HSA-1169408	1.053476e-01	0.977
Glycolysis	R-HSA-70171	6.194194e-01	0.208
Signaling by ALK	R-HSA-201556	3.562913e-01	0.448
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	6.114476e-01	0.214
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.218960e-01	0.206
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.434106e-01	0.843
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	5.648792e-01	0.248
Maturation of nucleoprotein	R-HSA-9683610	5.341318e-01	0.272
Transcriptional regulation by RUNX2	R-HSA-8878166	6.423156e-01	0.192
MAPK6/MAPK4 signaling	R-HSA-5687128	6.435558e-01	0.191
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.445070e-01	0.191
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.481633e-01	0.188
SHC1 events in ERBB4 signaling	R-HSA-1250347	6.481633e-01	0.188
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.481633e-01	0.188
Transcriptional regulation of testis differentiation	R-HSA-9690406	6.481633e-01	0.188
Fibronectin matrix formation	R-HSA-1566977	6.481633e-01	0.188
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	6.481633e-01	0.188
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.510846e-01	0.186
IFNG signaling activates MAPKs	R-HSA-9732724	6.510846e-01	0.186
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	6.510846e-01	0.186
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.510846e-01	0.186
Recycling of eIF2:GDP	R-HSA-72731	6.510846e-01	0.186
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.510846e-01	0.186
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	6.510846e-01	0.186
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	6.510846e-01	0.186
Synthesis of PIPs in the nucleus	R-HSA-8847453	6.510846e-01	0.186
VLDL clearance	R-HSA-8964046	6.510846e-01	0.186
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.510846e-01	0.186
Cation-coupled Chloride cotransporters	R-HSA-426117	6.510846e-01	0.186
CHL1 interactions	R-HSA-447041	6.510846e-01	0.186
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	6.543745e-01	0.184
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	6.543745e-01	0.184
Signaling by EGFR in Cancer	R-HSA-1643713	6.543745e-01	0.184
Fanconi Anemia Pathway	R-HSA-6783310	6.550207e-01	0.184
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	6.558063e-01	0.183
UCH proteinases	R-HSA-5689603	6.578402e-01	0.182
PRC2 methylates histones and DNA	R-HSA-212300	6.624423e-01	0.179
Calmodulin induced events	R-HSA-111933	6.624423e-01	0.179
CaM pathway	R-HSA-111997	6.624423e-01	0.179
Pre-NOTCH Expression and Processing	R-HSA-1912422	6.634535e-01	0.178
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	6.644470e-01	0.178
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.644470e-01	0.178
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	6.729597e-01	0.172
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.729597e-01	0.172
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.729597e-01	0.172
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.729597e-01	0.172
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.741244e-01	0.171
SHC-mediated cascade:FGFR2	R-HSA-5654699	6.745205e-01	0.171
EPHA-mediated growth cone collapse	R-HSA-3928663	6.745205e-01	0.171
Cristae formation	R-HSA-8949613	6.745205e-01	0.171
Signaling by BMP	R-HSA-201451	6.745205e-01	0.171
RNA Polymerase I Transcription Termination	R-HSA-73863	6.745205e-01	0.171
Signaling by NTRK2 (TRKB)	R-HSA-9006115	6.745205e-01	0.171
Maturation of hRSV A proteins	R-HSA-9828806	6.745205e-01	0.171
IRS-mediated signalling	R-HSA-112399	6.791419e-01	0.168
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.859661e-01	0.164
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.859661e-01	0.164
Co-stimulation by ICOS	R-HSA-9927354	6.859661e-01	0.164
FGFR1b ligand binding and activation	R-HSA-190370	6.859661e-01	0.164
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	6.859661e-01	0.164
ROBO receptors bind AKAP5	R-HSA-9010642	6.859661e-01	0.164
Downregulation of ERBB4 signaling	R-HSA-1253288	6.859661e-01	0.164
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	6.859661e-01	0.164
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	6.861892e-01	0.164
Diseases of programmed cell death	R-HSA-9645723	6.910655e-01	0.160
Formation of the Early Elongation Complex	R-HSA-113418	6.937865e-01	0.159
Telomere Extension By Telomerase	R-HSA-171319	6.937865e-01	0.159
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	6.937865e-01	0.159
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.939734e-01	0.159
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	6.963167e-01	0.157
Apoptotic factor-mediated response	R-HSA-111471	6.963167e-01	0.157
PKA activation	R-HSA-163615	6.963167e-01	0.157
Chaperone Mediated Autophagy	R-HSA-9613829	6.963167e-01	0.157
Vitamin D (calciferol) metabolism	R-HSA-196791	6.963167e-01	0.157
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.963167e-01	0.157
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	6.963167e-01	0.157
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.964306e-01	0.157
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.964306e-01	0.157
RAF/MAP kinase cascade	R-HSA-5673001	6.967708e-01	0.157
Toll-like Receptor Cascades	R-HSA-168898	7.030856e-01	0.153
Regulation of beta-cell development	R-HSA-186712	7.064738e-01	0.151
Cell-cell junction organization	R-HSA-421270	7.090257e-01	0.149
Late endosomal microautophagy	R-HSA-9615710	7.121779e-01	0.147
Termination of translesion DNA synthesis	R-HSA-5656169	7.121779e-01	0.147
Downstream signaling of activated FGFR3	R-HSA-5654708	7.121779e-01	0.147
Regulation of PD-L1(CD274) expression	R-HSA-9909648	7.122425e-01	0.147
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.122484e-01	0.147
Developmental Biology	R-HSA-1266738	7.126199e-01	0.147
DNA Damage Bypass	R-HSA-73893	7.153932e-01	0.145
ARMS-mediated activation	R-HSA-170984	7.173623e-01	0.144
WNT mediated activation of DVL	R-HSA-201688	7.173623e-01	0.144
MAPK1 (ERK2) activation	R-HSA-112411	7.173623e-01	0.144
p75NTR regulates axonogenesis	R-HSA-193697	7.173623e-01	0.144
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.173623e-01	0.144
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.173623e-01	0.144
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.173623e-01	0.144
Regulation of signaling by NODAL	R-HSA-1433617	7.173623e-01	0.144
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.173623e-01	0.144
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	7.173623e-01	0.144
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.173623e-01	0.144
Interleukin-1 processing	R-HSA-448706	7.173623e-01	0.144
Lipophagy	R-HSA-9613354	7.173623e-01	0.144
Cellular response to mitochondrial stress	R-HSA-9840373	7.173623e-01	0.144
Translesion Synthesis by POLH	R-HSA-110320	7.182744e-01	0.144
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	7.182744e-01	0.144
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	7.182744e-01	0.144
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.182744e-01	0.144
Crosslinking of collagen fibrils	R-HSA-2243919	7.182744e-01	0.144
E2F mediated regulation of DNA replication	R-HSA-113510	7.182744e-01	0.144
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	7.182744e-01	0.144
STING mediated induction of host immune responses	R-HSA-1834941	7.182744e-01	0.144
Maturation of nucleoprotein	R-HSA-9694631	7.182744e-01	0.144
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	7.200778e-01	0.143
Regulation of CDH1 Expression and Function	R-HSA-9764265	7.200778e-01	0.143
Separation of Sister Chromatids	R-HSA-2467813	7.213163e-01	0.142
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	7.242678e-01	0.140
PI3K Cascade	R-HSA-109704	7.292522e-01	0.137
Downregulation of ERBB2 signaling	R-HSA-8863795	7.297048e-01	0.137
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.297048e-01	0.137
Downstream signaling of activated FGFR4	R-HSA-5654716	7.297048e-01	0.137
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.388789e-01	0.131
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.388789e-01	0.131
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.388789e-01	0.131
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.388789e-01	0.131
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.388789e-01	0.131
Negative regulation of MET activity	R-HSA-6807004	7.388789e-01	0.131
Interleukin-1 signaling	R-HSA-9020702	7.395932e-01	0.131
MAPK1/MAPK3 signaling	R-HSA-5684996	7.398427e-01	0.131
VEGFR2 mediated vascular permeability	R-HSA-5218920	7.426840e-01	0.129
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	7.426840e-01	0.129
MAPK3 (ERK1) activation	R-HSA-110056	7.456213e-01	0.127
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.456213e-01	0.127
DNA replication initiation	R-HSA-68952	7.456213e-01	0.127
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.456213e-01	0.127
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.456213e-01	0.127
Formation of intermediate mesoderm	R-HSA-9761174	7.456213e-01	0.127
EGFR Transactivation by Gastrin	R-HSA-2179392	7.456213e-01	0.127
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.456213e-01	0.127
Receptor Mediated Mitophagy	R-HSA-8934903	7.456213e-01	0.127
Signaling by Leptin	R-HSA-2586552	7.456213e-01	0.127
Trafficking of AMPA receptors	R-HSA-399719	7.463813e-01	0.127
EGFR downregulation	R-HSA-182971	7.463813e-01	0.127
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.463813e-01	0.127
Ca2+ pathway	R-HSA-4086398	7.472616e-01	0.127
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	7.507074e-01	0.125
Signaling by WNT	R-HSA-195721	7.514362e-01	0.124
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	7.554883e-01	0.122
Signaling by FGFR1 in disease	R-HSA-5655302	7.568541e-01	0.121
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	7.568541e-01	0.121
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.581813e-01	0.120
DNA strand elongation	R-HSA-69190	7.622246e-01	0.118
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.688618e-01	0.114
Ca-dependent events	R-HSA-111996	7.704130e-01	0.113
Presynaptic depolarization and calcium channel opening	R-HSA-112308	7.710564e-01	0.113
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.710564e-01	0.113
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.710564e-01	0.113
Synthesis of PI	R-HSA-1483226	7.710564e-01	0.113
RHOBTB3 ATPase cycle	R-HSA-9706019	7.710564e-01	0.113
Bicarbonate transporters	R-HSA-425381	7.710564e-01	0.113
Transport of RCbl within the body	R-HSA-9758890	7.710564e-01	0.113
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	7.710564e-01	0.113
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	7.710564e-01	0.113
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.710564e-01	0.113
Suppression of apoptosis	R-HSA-9635465	7.710564e-01	0.113
PECAM1 interactions	R-HSA-210990	7.710564e-01	0.113
tRNA processing	R-HSA-72306	7.735333e-01	0.112
MHC class II antigen presentation	R-HSA-2132295	7.749567e-01	0.111
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.762360e-01	0.110
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.762360e-01	0.110
Molybdenum cofactor biosynthesis	R-HSA-947581	7.762360e-01	0.110
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	7.762360e-01	0.110
RSV-host interactions	R-HSA-9833110	7.764457e-01	0.110
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	7.772549e-01	0.109
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	7.772549e-01	0.109
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	7.772549e-01	0.109
FGFR1 mutant receptor activation	R-HSA-1839124	7.772549e-01	0.109
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	7.805507e-01	0.108
Signaling by FGFR4	R-HSA-5654743	7.833709e-01	0.106
Striated Muscle Contraction	R-HSA-390522	7.914947e-01	0.102
Glucagon signaling in metabolic regulation	R-HSA-163359	7.914947e-01	0.102
Effects of PIP2 hydrolysis	R-HSA-114508	7.914947e-01	0.102
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.930994e-01	0.101
FGFR2 alternative splicing	R-HSA-6803529	7.930994e-01	0.101
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.930994e-01	0.101
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	7.930994e-01	0.101
Signaling by KIT in disease	R-HSA-9669938	7.930994e-01	0.101
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.939495e-01	0.100
ERKs are inactivated	R-HSA-202670	7.939495e-01	0.100
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.939495e-01	0.100
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	7.939495e-01	0.100
DS-GAG biosynthesis	R-HSA-2022923	7.939495e-01	0.100
Integration of provirus	R-HSA-162592	7.939495e-01	0.100
Signaling by FGFR1	R-HSA-5654736	8.021538e-01	0.096
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	8.049680e-01	0.094
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.075333e-01	0.093
DAG and IP3 signaling	R-HSA-1489509	8.075333e-01	0.093
Signaling by FGFR3	R-HSA-5654741	8.075333e-01	0.093
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.088291e-01	0.092
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.088291e-01	0.092
Carnitine shuttle	R-HSA-200425	8.088291e-01	0.092
Growth hormone receptor signaling	R-HSA-982772	8.088291e-01	0.092
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	8.093909e-01	0.092
Regulated Necrosis	R-HSA-5218859	8.093909e-01	0.092
ESR-mediated signaling	R-HSA-8939211	8.094924e-01	0.092
Glucose metabolism	R-HSA-70326	8.109996e-01	0.091
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	8.145547e-01	0.089
Polymerase switching	R-HSA-69091	8.145547e-01	0.089
Leading Strand Synthesis	R-HSA-69109	8.145547e-01	0.089
GRB2 events in EGFR signaling	R-HSA-179812	8.145547e-01	0.089
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.145547e-01	0.089
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.145547e-01	0.089
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.145547e-01	0.089
VLDLR internalisation and degradation	R-HSA-8866427	8.145547e-01	0.089
Role of second messengers in netrin-1 signaling	R-HSA-418890	8.145547e-01	0.089
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.177005e-01	0.087
Downstream signaling of activated FGFR2	R-HSA-5654696	8.177005e-01	0.087
Downstream signaling of activated FGFR1	R-HSA-5654687	8.177005e-01	0.087
Diseases of DNA repair	R-HSA-9675135	8.187657e-01	0.087
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.188498e-01	0.087
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.216712e-01	0.085
Cellular response to starvation	R-HSA-9711097	8.257904e-01	0.083
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	8.294523e-01	0.081
Triglyceride catabolism	R-HSA-163560	8.297190e-01	0.081
Deadenylation-dependent mRNA decay	R-HSA-429914	8.323035e-01	0.080
Adenylate cyclase activating pathway	R-HSA-170660	8.331005e-01	0.079
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.331005e-01	0.079
Platelet Adhesion to exposed collagen	R-HSA-75892	8.331005e-01	0.079
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.331005e-01	0.079
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	8.331005e-01	0.079
FGFR1c ligand binding and activation	R-HSA-190373	8.331005e-01	0.079
Processing of SMDT1	R-HSA-8949664	8.331005e-01	0.079
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.331005e-01	0.079
Interleukin-6 signaling	R-HSA-1059683	8.331005e-01	0.079
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.331005e-01	0.079
NoRC negatively regulates rRNA expression	R-HSA-427413	8.366502e-01	0.077
Long-term potentiation	R-HSA-9620244	8.371197e-01	0.077
Acyl chain remodelling of PS	R-HSA-1482801	8.371197e-01	0.077
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.371197e-01	0.077
Interleukin-7 signaling	R-HSA-1266695	8.371197e-01	0.077
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	8.388578e-01	0.076
Chromosome Maintenance	R-HSA-73886	8.389329e-01	0.076
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	8.396094e-01	0.076
Signaling by Insulin receptor	R-HSA-74752	8.398048e-01	0.076
EPH-Ephrin signaling	R-HSA-2682334	8.398048e-01	0.076
NCAM1 interactions	R-HSA-419037	8.410507e-01	0.075
Cytoprotection by HMOX1	R-HSA-9707564	8.417266e-01	0.075
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	8.433462e-01	0.074
Removal of the Flap Intermediate	R-HSA-69166	8.497925e-01	0.071
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.497925e-01	0.071
NRIF signals cell death from the nucleus	R-HSA-205043	8.497925e-01	0.071
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.497925e-01	0.071
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.497925e-01	0.071
Physiological factors	R-HSA-5578768	8.497925e-01	0.071
Signaling by FGFR4 in disease	R-HSA-5655291	8.497925e-01	0.071
HDL assembly	R-HSA-8963896	8.497925e-01	0.071
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.497925e-01	0.071
Attachment of bacteria to epithelial cells	R-HSA-9638630	8.497952e-01	0.071
MET activates PTK2 signaling	R-HSA-8874081	8.497952e-01	0.071
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.497952e-01	0.071
TRP channels	R-HSA-3295583	8.497952e-01	0.071
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	8.497952e-01	0.071
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.517236e-01	0.070
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.517236e-01	0.070
NCAM signaling for neurite out-growth	R-HSA-375165	8.585956e-01	0.066
Signaling by ERBB4	R-HSA-1236394	8.606771e-01	0.065
Interaction between L1 and Ankyrins	R-HSA-445095	8.615656e-01	0.065
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	8.615656e-01	0.065
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	8.615656e-01	0.065
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	8.615656e-01	0.065
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.615656e-01	0.065
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	8.617658e-01	0.065
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.617658e-01	0.065
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.617658e-01	0.065
Interferon Signaling	R-HSA-913531	8.637009e-01	0.064
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	8.648160e-01	0.063
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.648160e-01	0.063
RNA Polymerase III Chain Elongation	R-HSA-73780	8.648160e-01	0.063
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.648160e-01	0.063
Processive synthesis on the lagging strand	R-HSA-69183	8.648160e-01	0.063
Telomere C-strand synthesis initiation	R-HSA-174430	8.648160e-01	0.063
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	8.648160e-01	0.063
Translesion synthesis by REV1	R-HSA-110312	8.648160e-01	0.063
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.648160e-01	0.063
Spry regulation of FGF signaling	R-HSA-1295596	8.648160e-01	0.063
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	8.648160e-01	0.063
p38MAPK events	R-HSA-171007	8.648160e-01	0.063
IRF3-mediated induction of type I IFN	R-HSA-3270619	8.648160e-01	0.063
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	8.648160e-01	0.063
Protein methylation	R-HSA-8876725	8.648160e-01	0.063
Other semaphorin interactions	R-HSA-416700	8.648160e-01	0.063
Attenuation phase	R-HSA-3371568	8.712053e-01	0.060
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	8.712053e-01	0.060
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	8.712053e-01	0.060
HIV Transcription Elongation	R-HSA-167169	8.712053e-01	0.060
Aggrephagy	R-HSA-9646399	8.712053e-01	0.060
Nuclear signaling by ERBB4	R-HSA-1251985	8.712053e-01	0.060
HIV elongation arrest and recovery	R-HSA-167287	8.724852e-01	0.059
Activation of AMPK downstream of NMDARs	R-HSA-9619483	8.724852e-01	0.059
Pausing and recovery of HIV elongation	R-HSA-167290	8.724852e-01	0.059
Pyroptosis	R-HSA-5620971	8.724852e-01	0.059
Inflammasomes	R-HSA-622312	8.724852e-01	0.059
Formation of RNA Pol II elongation complex	R-HSA-112382	8.752842e-01	0.058
RNA Polymerase I Promoter Escape	R-HSA-73772	8.752842e-01	0.058
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.752842e-01	0.058
Uptake and actions of bacterial toxins	R-HSA-5339562	8.752842e-01	0.058
Post NMDA receptor activation events	R-HSA-438064	8.770793e-01	0.057
Class I peroxisomal membrane protein import	R-HSA-9603798	8.783377e-01	0.056
Translesion synthesis by POLI	R-HSA-5656121	8.783377e-01	0.056
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.783377e-01	0.056
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	8.783377e-01	0.056
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.783377e-01	0.056
Regulation of NF-kappa B signaling	R-HSA-9758274	8.783377e-01	0.056
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.783377e-01	0.056
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.800701e-01	0.055
Resolution of Abasic Sites (AP sites)	R-HSA-73933	8.800701e-01	0.055
Co-inhibition by PD-1	R-HSA-389948	8.809868e-01	0.055
Cellular response to hypoxia	R-HSA-1234174	8.813468e-01	0.055
mRNA Capping	R-HSA-72086	8.826062e-01	0.054
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	8.826062e-01	0.054
Platelet calcium homeostasis	R-HSA-418360	8.826062e-01	0.054
Regulation of gene expression in beta cells	R-HSA-210745	8.826062e-01	0.054
Glucagon-type ligand receptors	R-HSA-420092	8.826062e-01	0.054
Vesicle-mediated transport	R-HSA-5653656	8.830126e-01	0.054
RNA Polymerase II Transcription Elongation	R-HSA-75955	8.830523e-01	0.054
Meiotic synapsis	R-HSA-1221632	8.830523e-01	0.054
Amino acids regulate mTORC1	R-HSA-9639288	8.830523e-01	0.054
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.830523e-01	0.054
Selective autophagy	R-HSA-9663891	8.833013e-01	0.054
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	8.880945e-01	0.052
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.883877e-01	0.051
DNA Replication Pre-Initiation	R-HSA-69002	8.884659e-01	0.051
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.903957e-01	0.050
G beta:gamma signalling through CDC42	R-HSA-8964616	8.905076e-01	0.050
Translesion synthesis by POLK	R-HSA-5655862	8.905076e-01	0.050
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	8.905076e-01	0.050
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.905076e-01	0.050
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	8.905076e-01	0.050
Coenzyme A biosynthesis	R-HSA-196783	8.905076e-01	0.050
Synthesis of PG	R-HSA-1483148	8.905076e-01	0.050
Scavenging by Class B Receptors	R-HSA-3000471	8.905076e-01	0.050
tRNA modification in the mitochondrion	R-HSA-6787450	8.905076e-01	0.050
Signaling by ROBO receptors	R-HSA-376176	8.931126e-01	0.049
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.961852e-01	0.048
Cleavage of the damaged pyrimidine	R-HSA-110329	8.961852e-01	0.048
Depyrimidination	R-HSA-73928	8.961852e-01	0.048
G alpha (z) signalling events	R-HSA-418597	8.973321e-01	0.047
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.999940e-01	0.046
Signaling by FGFR2	R-HSA-5654738	8.999940e-01	0.046
Budding and maturation of HIV virion	R-HSA-162588	9.006524e-01	0.045
Molecules associated with elastic fibres	R-HSA-2129379	9.006524e-01	0.045
PI3K events in ERBB2 signaling	R-HSA-1963642	9.014608e-01	0.045
Glycogen storage diseases	R-HSA-3229121	9.014608e-01	0.045
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.014608e-01	0.045
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	9.014608e-01	0.045
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	9.014608e-01	0.045
Catecholamine biosynthesis	R-HSA-209905	9.014608e-01	0.045
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.014608e-01	0.045
Extra-nuclear estrogen signaling	R-HSA-9009391	9.016646e-01	0.045
Defective pyroptosis	R-HSA-9710421	9.034891e-01	0.044
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.038789e-01	0.044
HIV Infection	R-HSA-162906	9.048879e-01	0.043
SARS-CoV-2-host interactions	R-HSA-9705683	9.082126e-01	0.042
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.086721e-01	0.042
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.086721e-01	0.042
Amine ligand-binding receptors	R-HSA-375280	9.103253e-01	0.041
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	9.107906e-01	0.041
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.113189e-01	0.040
Ephrin signaling	R-HSA-3928664	9.113189e-01	0.040
Synaptic adhesion-like molecules	R-HSA-8849932	9.113189e-01	0.040
FGFR1 ligand binding and activation	R-HSA-190242	9.113189e-01	0.040
Mismatch Repair	R-HSA-5358508	9.113189e-01	0.040
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.113189e-01	0.040
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.113189e-01	0.040
COPII-mediated vesicle transport	R-HSA-204005	9.123150e-01	0.040
Cellular responses to mechanical stimuli	R-HSA-9855142	9.125151e-01	0.040
Host Interactions of HIV factors	R-HSA-162909	9.141789e-01	0.039
Assembly of the pre-replicative complex	R-HSA-68867	9.153291e-01	0.038
Opioid Signalling	R-HSA-111885	9.157410e-01	0.038
Response of endothelial cells to shear stress	R-HSA-9860931	9.157410e-01	0.038
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.160822e-01	0.038
Metabolism of RNA	R-HSA-8953854	9.161708e-01	0.038
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.167187e-01	0.038
ECM proteoglycans	R-HSA-3000178	9.175796e-01	0.037
Collagen formation	R-HSA-1474290	9.198554e-01	0.036
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.201912e-01	0.036
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	9.201912e-01	0.036
Diseases of hemostasis	R-HSA-9671793	9.201912e-01	0.036
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	9.201912e-01	0.036
The NLRP3 inflammasome	R-HSA-844456	9.201912e-01	0.036
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.201912e-01	0.036
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	9.205617e-01	0.036
Extension of Telomeres	R-HSA-180786	9.213529e-01	0.036
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.229243e-01	0.035
Miscellaneous transport and binding events	R-HSA-5223345	9.229243e-01	0.035
Signaling by Nuclear Receptors	R-HSA-9006931	9.241794e-01	0.034
Beta-catenin independent WNT signaling	R-HSA-3858494	9.270584e-01	0.033
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	9.272781e-01	0.033
Switching of origins to a post-replicative state	R-HSA-69052	9.272781e-01	0.033
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.281764e-01	0.032
Glycogen synthesis	R-HSA-3322077	9.281764e-01	0.032
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.281764e-01	0.032
Pregnenolone biosynthesis	R-HSA-196108	9.281764e-01	0.032
Protein hydroxylation	R-HSA-9629569	9.281764e-01	0.032
ER to Golgi Anterograde Transport	R-HSA-199977	9.286009e-01	0.032
PLC beta mediated events	R-HSA-112043	9.313615e-01	0.031
Aquaporin-mediated transport	R-HSA-445717	9.313615e-01	0.031
Formation of paraxial mesoderm	R-HSA-9793380	9.313615e-01	0.031
Signaling by NOTCH4	R-HSA-9013694	9.317356e-01	0.031
ROS and RNS production in phagocytes	R-HSA-1222556	9.317356e-01	0.031
COPI-mediated anterograde transport	R-HSA-6807878	9.321968e-01	0.030
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.321968e-01	0.030
XBP1(S) activates chaperone genes	R-HSA-381038	9.334606e-01	0.030
PERK regulates gene expression	R-HSA-381042	9.350603e-01	0.029
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.353630e-01	0.029
Lagging Strand Synthesis	R-HSA-69186	9.353630e-01	0.029
Basigin interactions	R-HSA-210991	9.353630e-01	0.029
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.353630e-01	0.029
Early Phase of HIV Life Cycle	R-HSA-162594	9.353630e-01	0.029
Chaperonin-mediated protein folding	R-HSA-390466	9.373282e-01	0.028
Degradation of CDH1	R-HSA-9766229	9.383388e-01	0.028
Gap junction trafficking and regulation	R-HSA-157858	9.383388e-01	0.028
Signaling by FGFR	R-HSA-190236	9.394675e-01	0.027
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.402036e-01	0.027
Regulation of TP53 Degradation	R-HSA-6804757	9.404264e-01	0.027
HCMV Early Events	R-HSA-9609690	9.409765e-01	0.026
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.418310e-01	0.026
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.418310e-01	0.026
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.418310e-01	0.026
Assembly Of The HIV Virion	R-HSA-175474	9.418310e-01	0.026
Glutathione synthesis and recycling	R-HSA-174403	9.418310e-01	0.026
Mitochondrial calcium ion transport	R-HSA-8949215	9.418310e-01	0.026
Signaling by Interleukins	R-HSA-449147	9.425542e-01	0.026
Macroautophagy	R-HSA-1632852	9.425886e-01	0.026
Degradation of AXIN	R-HSA-4641257	9.453693e-01	0.024
Cleavage of the damaged purine	R-HSA-110331	9.453693e-01	0.024
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.470828e-01	0.024
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.476520e-01	0.023
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.476520e-01	0.023
Ethanol oxidation	R-HSA-71384	9.476520e-01	0.023
LDL clearance	R-HSA-8964038	9.476520e-01	0.023
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.476520e-01	0.023
Neurotransmitter release cycle	R-HSA-112310	9.477578e-01	0.023
Cytokine Signaling in Immune system	R-HSA-1280215	9.496502e-01	0.022
Depurination	R-HSA-73927	9.499199e-01	0.022
Biofilm formation	R-HSA-9931953	9.499199e-01	0.022
Elastic fibre formation	R-HSA-1566948	9.499199e-01	0.022
Influenza Viral RNA Transcription and Replication	R-HSA-168273	9.509297e-01	0.022
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.510086e-01	0.022
Orc1 removal from chromatin	R-HSA-68949	9.510086e-01	0.022
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.515322e-01	0.022
Mitochondrial mRNA modification	R-HSA-9937008	9.528909e-01	0.021
Organic anion transport by SLCO transporters	R-HSA-879518	9.528909e-01	0.021
ABC transporters in lipid homeostasis	R-HSA-1369062	9.528909e-01	0.021
Autophagy	R-HSA-9612973	9.532389e-01	0.021
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.537016e-01	0.021
IRE1alpha activates chaperones	R-HSA-381070	9.538163e-01	0.021
Stabilization of p53	R-HSA-69541	9.541072e-01	0.020
Plasma lipoprotein clearance	R-HSA-8964043	9.541072e-01	0.020
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.546611e-01	0.020
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	9.546611e-01	0.020
G-protein mediated events	R-HSA-112040	9.548464e-01	0.020
HCMV Late Events	R-HSA-9610379	9.554520e-01	0.020
Protein folding	R-HSA-391251	9.566009e-01	0.019
Mitochondrial RNA degradation	R-HSA-9836573	9.576057e-01	0.019
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.576057e-01	0.019
TNFs bind their physiological receptors	R-HSA-5669034	9.576057e-01	0.019
Plasma lipoprotein assembly	R-HSA-8963898	9.576057e-01	0.019
Interleukin-6 family signaling	R-HSA-6783589	9.576057e-01	0.019
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.576138e-01	0.019
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.579583e-01	0.019
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.579583e-01	0.019
Generation of second messenger molecules	R-HSA-202433	9.579583e-01	0.019
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.579583e-01	0.019
Diseases of Immune System	R-HSA-5260271	9.579583e-01	0.019
Translation initiation complex formation	R-HSA-72649	9.580576e-01	0.019
Interferon gamma signaling	R-HSA-877300	9.596033e-01	0.018
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.607933e-01	0.017
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.612143e-01	0.017
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.614986e-01	0.017
G alpha (s) signalling events	R-HSA-418555	9.618081e-01	0.017
Activation of G protein gated Potassium channels	R-HSA-1296041	9.618489e-01	0.017
G protein gated Potassium channels	R-HSA-1296059	9.618489e-01	0.017
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.618489e-01	0.017
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.618489e-01	0.017
Tight junction interactions	R-HSA-420029	9.618489e-01	0.017
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.618489e-01	0.017
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.618489e-01	0.017
Polymerase switching on the C-strand of the telomere	R-HSA-174411	9.618489e-01	0.017
Alpha-oxidation of phytanate	R-HSA-389599	9.618489e-01	0.017
Nucleotide Excision Repair	R-HSA-5696398	9.621060e-01	0.017
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.635747e-01	0.016
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	9.641466e-01	0.016
Ribosomal scanning and start codon recognition	R-HSA-72702	9.641466e-01	0.016
SARS-CoV-1-host interactions	R-HSA-9692914	9.643170e-01	0.016
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.647516e-01	0.016
Intra-Golgi traffic	R-HSA-6811438	9.647516e-01	0.016
Scavenging by Class A Receptors	R-HSA-3000480	9.647516e-01	0.016
Translation of Structural Proteins	R-HSA-9683701	9.647516e-01	0.016
Suppression of phagosomal maturation	R-HSA-9637687	9.656677e-01	0.015
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.656677e-01	0.015
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.656677e-01	0.015
Regulation of mitotic cell cycle	R-HSA-453276	9.661170e-01	0.015
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	9.661170e-01	0.015
Regulation of CDH1 Function	R-HSA-9764561	9.668691e-01	0.015
GABA B receptor activation	R-HSA-977444	9.677394e-01	0.014
Activation of GABAB receptors	R-HSA-991365	9.677394e-01	0.014
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	9.677394e-01	0.014
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.679196e-01	0.014
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.683911e-01	0.014
Stimuli-sensing channels	R-HSA-2672351	9.683911e-01	0.014
Developmental Lineages of the Mammary Gland	R-HSA-9924644	9.684933e-01	0.014
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	9.684933e-01	0.014
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.684933e-01	0.014
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.686634e-01	0.014
Regulation of T cell activation by CD28 family	R-HSA-388841	9.690998e-01	0.014
Packaging Of Telomere Ends	R-HSA-171306	9.691044e-01	0.014
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.691044e-01	0.014
RNA Polymerase I Promoter Opening	R-HSA-73728	9.691044e-01	0.014
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.691044e-01	0.014
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.691044e-01	0.014
Signaling by FGFR3 in disease	R-HSA-5655332	9.691044e-01	0.014
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.691044e-01	0.014
Insulin processing	R-HSA-264876	9.691044e-01	0.014
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	9.693956e-01	0.013
Telomere Maintenance	R-HSA-157579	9.703386e-01	0.013
Response of Mtb to phagocytosis	R-HSA-9637690	9.704825e-01	0.013
Triglyceride metabolism	R-HSA-8979227	9.717391e-01	0.012
Phase 0 - rapid depolarisation	R-HSA-5576892	9.721972e-01	0.012
Negative regulation of FGFR3 signaling	R-HSA-5654732	9.721972e-01	0.012
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.721972e-01	0.012
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.721972e-01	0.012
Signaling by FGFR in disease	R-HSA-1226099	9.727862e-01	0.012
SLC transporter disorders	R-HSA-5619102	9.729817e-01	0.012
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.729999e-01	0.012
EPHB-mediated forward signaling	R-HSA-3928662	9.729999e-01	0.012
Gap junction trafficking	R-HSA-190828	9.729999e-01	0.012
Surfactant metabolism	R-HSA-5683826	9.729999e-01	0.012
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.739118e-01	0.011
Influenza Infection	R-HSA-168255	9.742162e-01	0.011
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.747210e-01	0.011
DNA methylation	R-HSA-5334118	9.749806e-01	0.011
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.749806e-01	0.011
Negative regulation of FGFR4 signaling	R-HSA-5654733	9.749806e-01	0.011
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.749806e-01	0.011
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.749806e-01	0.011
FCERI mediated MAPK activation	R-HSA-2871796	9.752926e-01	0.011
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.753093e-01	0.011
Asymmetric localization of PCP proteins	R-HSA-4608870	9.753093e-01	0.011
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.759253e-01	0.011
Platelet activation, signaling and aggregation	R-HSA-76002	9.765314e-01	0.010
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.774271e-01	0.010
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.774271e-01	0.010
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.774856e-01	0.010
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.774856e-01	0.010
Neurotransmitter clearance	R-HSA-112311	9.774856e-01	0.010
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.774856e-01	0.010
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.777904e-01	0.010
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.793685e-01	0.009
Cargo concentration in the ER	R-HSA-5694530	9.797398e-01	0.009
PCP/CE pathway	R-HSA-4086400	9.797785e-01	0.009
Cholesterol biosynthesis	R-HSA-191273	9.797785e-01	0.009
Integrin cell surface interactions	R-HSA-216083	9.797785e-01	0.009
Co-stimulation by CD28	R-HSA-389356	9.811476e-01	0.008
Inwardly rectifying K+ channels	R-HSA-1296065	9.817685e-01	0.008
Potential therapeutics for SARS	R-HSA-9679191	9.822064e-01	0.008
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.825946e-01	0.008
Cellular responses to stress	R-HSA-2262752	9.827636e-01	0.008
Unfolded Protein Response (UPR)	R-HSA-381119	9.829490e-01	0.007
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.835941e-01	0.007
Defective B3GALTL causes PpS	R-HSA-5083635	9.835941e-01	0.007
G-protein beta:gamma signalling	R-HSA-397795	9.835941e-01	0.007
Negative regulation of FGFR1 signaling	R-HSA-5654726	9.835941e-01	0.007
Recycling of bile acids and salts	R-HSA-159418	9.835941e-01	0.007
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.839279e-01	0.007
Parasite infection	R-HSA-9664407	9.839279e-01	0.007
Leishmania phagocytosis	R-HSA-9664417	9.839279e-01	0.007
Regulation of RAS by GAPs	R-HSA-5658442	9.842700e-01	0.007
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.848546e-01	0.007
Kidney development	R-HSA-9830369	9.852266e-01	0.006
Nicotinate metabolism	R-HSA-196807	9.852266e-01	0.006
Acyl chain remodelling of PC	R-HSA-1482788	9.852370e-01	0.006
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.852370e-01	0.006
Hedgehog ligand biogenesis	R-HSA-5358346	9.856364e-01	0.006
Synthesis of DNA	R-HSA-69239	9.856796e-01	0.006
HCMV Infection	R-HSA-9609646	9.857203e-01	0.006
Reproduction	R-HSA-1474165	9.857815e-01	0.006
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.858948e-01	0.006
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.866208e-01	0.006
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.866208e-01	0.006
eNOS activation	R-HSA-203615	9.867155e-01	0.006
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.867155e-01	0.006
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.867155e-01	0.006
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.867155e-01	0.006
Mitophagy	R-HSA-5205647	9.867155e-01	0.006
Calnexin/calreticulin cycle	R-HSA-901042	9.867155e-01	0.006
Hyaluronan metabolism	R-HSA-2142845	9.867155e-01	0.006
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.867155e-01	0.006
NPAS4 regulates expression of target genes	R-HSA-9768919	9.867155e-01	0.006
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.868871e-01	0.006
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.868871e-01	0.006
Degradation of the extracellular matrix	R-HSA-1474228	9.874489e-01	0.005
Regulation of PTEN stability and activity	R-HSA-8948751	9.880314e-01	0.005
Smooth Muscle Contraction	R-HSA-445355	9.880314e-01	0.005
Acyl chain remodelling of PE	R-HSA-1482839	9.880460e-01	0.005
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.880460e-01	0.005
Transferrin endocytosis and recycling	R-HSA-917977	9.880460e-01	0.005
Meiosis	R-HSA-1500620	9.881167e-01	0.005
TCR signaling	R-HSA-202403	9.883315e-01	0.005
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.889415e-01	0.005
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.890781e-01	0.005
HSF1 activation	R-HSA-3371511	9.892433e-01	0.005
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.892433e-01	0.005
Lysosome Vesicle Biogenesis	R-HSA-432720	9.892433e-01	0.005
Glycosphingolipid transport	R-HSA-9845576	9.892433e-01	0.005
Regulation of insulin secretion	R-HSA-422356	9.892441e-01	0.005
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.898346e-01	0.004
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.898346e-01	0.004
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.903208e-01	0.004
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.903208e-01	0.004
Degradation of DVL	R-HSA-4641258	9.903208e-01	0.004
SLC-mediated transport of organic cations	R-HSA-549127	9.903208e-01	0.004
Metabolism of folate and pterines	R-HSA-196757	9.903208e-01	0.004
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.909104e-01	0.004
Ion homeostasis	R-HSA-5578775	9.909104e-01	0.004
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.911880e-01	0.004
tRNA processing in the mitochondrion	R-HSA-6785470	9.912904e-01	0.004
SARS-CoV-1 Infection	R-HSA-9678108	9.916851e-01	0.004
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.921629e-01	0.003
Pentose phosphate pathway	R-HSA-71336	9.921629e-01	0.003
Protein ubiquitination	R-HSA-8852135	9.924131e-01	0.003
Dual incision in TC-NER	R-HSA-6782135	9.924411e-01	0.003
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.924411e-01	0.003
Cellular responses to stimuli	R-HSA-8953897	9.925136e-01	0.003
Downstream TCR signaling	R-HSA-202424	9.925470e-01	0.003
Base Excision Repair	R-HSA-73884	9.925470e-01	0.003
Glycogen metabolism	R-HSA-8982491	9.929480e-01	0.003
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.929480e-01	0.003
rRNA processing in the mitochondrion	R-HSA-8868766	9.929480e-01	0.003
Interleukin-12 signaling	R-HSA-9020591	9.930272e-01	0.003
Peroxisomal protein import	R-HSA-9033241	9.931087e-01	0.003
DNA Replication	R-HSA-69306	9.931611e-01	0.003
Eukaryotic Translation Initiation	R-HSA-72613	9.933207e-01	0.003
Cap-dependent Translation Initiation	R-HSA-72737	9.933207e-01	0.003
Translation of Structural Proteins	R-HSA-9694635	9.935930e-01	0.003
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.936334e-01	0.003
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.936546e-01	0.003
Maturation of spike protein	R-HSA-9694548	9.936546e-01	0.003
GABA receptor activation	R-HSA-977443	9.937186e-01	0.003
Signaling by Retinoic Acid	R-HSA-5362517	9.937186e-01	0.003
Endogenous sterols	R-HSA-211976	9.942754e-01	0.002
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.942904e-01	0.002
Degradation of CRY and PER proteins	R-HSA-9932298	9.942904e-01	0.002
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.942904e-01	0.002
Platelet homeostasis	R-HSA-418346	9.944683e-01	0.002
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.945666e-01	0.002
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.947838e-01	0.002
Mitochondrial protein import	R-HSA-1268020	9.947838e-01	0.002
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.948625e-01	0.002
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.949824e-01	0.002
C-type lectin receptors (CLRs)	R-HSA-5621481	9.951897e-01	0.002
Antigen processing-Cross presentation	R-HSA-1236975	9.952411e-01	0.002
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.953674e-01	0.002
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.953773e-01	0.002
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.957238e-01	0.002
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.958405e-01	0.002
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.958405e-01	0.002
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.958937e-01	0.002
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.959534e-01	0.002
SARS-CoV-2 Infection	R-HSA-9694516	9.960519e-01	0.002
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.961616e-01	0.002
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.962574e-01	0.002
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.962574e-01	0.002
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.962574e-01	0.002
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.962574e-01	0.002
Transport to the Golgi and subsequent modification	R-HSA-948021	9.963510e-01	0.002
Integration of energy metabolism	R-HSA-163685	9.963767e-01	0.002
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.966325e-01	0.001
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.966325e-01	0.001
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.966325e-01	0.001
Cellular response to chemical stress	R-HSA-9711123	9.968997e-01	0.001
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.969700e-01	0.001
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.969700e-01	0.001
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.970372e-01	0.001
ABC-family proteins mediated transport	R-HSA-382556	9.971437e-01	0.001
Platelet degranulation	R-HSA-114608	9.971902e-01	0.001
Phospholipid metabolism	R-HSA-1483257	9.972097e-01	0.001
Protein localization	R-HSA-9609507	9.972124e-01	0.001
Intraflagellar transport	R-HSA-5620924	9.972737e-01	0.001
Interleukin-12 family signaling	R-HSA-447115	9.975092e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.975350e-01	0.001
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.975470e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.975470e-01	0.001
Interferon alpha/beta signaling	R-HSA-909733	9.976089e-01	0.001
Peptide chain elongation	R-HSA-156902	9.977169e-01	0.001
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.977570e-01	0.001
Metabolism of cofactors	R-HSA-8978934	9.977570e-01	0.001
Signaling by FGFR2 in disease	R-HSA-5655253	9.977929e-01	0.001
Azathioprine ADME	R-HSA-9748787	9.977929e-01	0.001
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.978658e-01	0.001
Meiotic recombination	R-HSA-912446	9.980142e-01	0.001
Activation of NF-kappaB in B cells	R-HSA-1169091	9.980142e-01	0.001
Complex IV assembly	R-HSA-9864848	9.980142e-01	0.001
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.980209e-01	0.001
Class B/2 (Secretin family receptors)	R-HSA-373080	9.980827e-01	0.001
Diseases of carbohydrate metabolism	R-HSA-5663084	9.981434e-01	0.001
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.982435e-01	0.001
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.983286e-01	0.001
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.984641e-01	0.001
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.985029e-01	0.001
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.985181e-01	0.001
Eukaryotic Translation Elongation	R-HSA-156842	9.985265e-01	0.001
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.985265e-01	0.001
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.985265e-01	0.001
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.986987e-01	0.001
Transmission across Chemical Synapses	R-HSA-112315	9.987692e-01	0.001
Adaptive Immune System	R-HSA-1280218	9.987844e-01	0.001
Metabolism of amine-derived hormones	R-HSA-209776	9.988292e-01	0.001
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.988440e-01	0.001
SLC-mediated transport of organic anions	R-HSA-9955298	9.988454e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.988454e-01	0.001
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.989255e-01	0.000
Synthesis of PA	R-HSA-1483166	9.989466e-01	0.000
Eukaryotic Translation Termination	R-HSA-72764	9.989650e-01	0.000
Formation of a pool of free 40S subunits	R-HSA-72689	9.989650e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.990529e-01	0.000
Potassium Channels	R-HSA-1296071	9.990529e-01	0.000
RAB geranylgeranylation	R-HSA-8873719	9.992328e-01	0.000
Glutathione conjugation	R-HSA-156590	9.992328e-01	0.000
Leishmania infection	R-HSA-9658195	9.992795e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.992795e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.993495e-01	0.000
SARS-CoV Infections	R-HSA-9679506	9.993731e-01	0.000
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.993750e-01	0.000
Selenocysteine synthesis	R-HSA-2408557	9.993935e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.994413e-01	0.000
Viral mRNA Translation	R-HSA-192823	9.994931e-01	0.000
Glycosphingolipid biosynthesis	R-HSA-9840309	9.994974e-01	0.000
Ion transport by P-type ATPases	R-HSA-936837	9.994974e-01	0.000
Xenobiotics	R-HSA-211981	9.994974e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.995106e-01	0.000
Hemostasis	R-HSA-109582	9.995552e-01	0.000
Neddylation	R-HSA-8951664	9.995667e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.995979e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.996340e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.996340e-01	0.000
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.996707e-01	0.000
Ribosome-associated quality control	R-HSA-9948299	9.997000e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.997017e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.997603e-01	0.000
Neuronal System	R-HSA-112316	9.997849e-01	0.000
Ion channel transport	R-HSA-983712	9.998015e-01	0.000
Developmental Cell Lineages	R-HSA-9734767	9.998267e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.998430e-01	0.000
Iron uptake and transport	R-HSA-917937	9.998430e-01	0.000
Post-translational protein phosphorylation	R-HSA-8957275	9.998744e-01	0.000
ABC transporter disorders	R-HSA-5619084	9.998857e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.998972e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.998972e-01	0.000
Amyloid fiber formation	R-HSA-977225	9.999168e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999168e-01	0.000
rRNA processing	R-HSA-72312	9.999273e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.999559e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999612e-01	0.000
ER-Phagosome pathway	R-HSA-1236974	9.999679e-01	0.000
Muscle contraction	R-HSA-397014	9.999681e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999683e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999730e-01	0.000
Cardiac conduction	R-HSA-5576891	9.999754e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999785e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999804e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999808e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999824e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.999830e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999855e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999876e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999900e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999903e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999910e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.999940e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999952e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999956e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999966e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999971e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999975e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999976e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999976e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999981e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999987e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999991e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.999991e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999994e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999995e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999995e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999996e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999996e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999997e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999998e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000
Keratinization	R-HSA-6805567	9.999999e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999999e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.999999e-01	0.000
Viral Infection Pathways	R-HSA-9824446	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Visual phototransduction	R-HSA-2187338	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Immune System	R-HSA-168256	1.000000e+00	0.000
Post-translational protein modification	R-HSA-597592	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Neutrophil degranulation	R-HSA-6798695	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Innate Immune System	R-HSA-168249	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Translation	R-HSA-72766	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	5.673774e-09	8.246
Apoptotic execution phase	R-HSA-75153	1.062741e-07	6.974
Cell Cycle, Mitotic	R-HSA-69278	1.545812e-07	6.811
M Phase	R-HSA-68886	5.648791e-06	5.248
Programmed Cell Death	R-HSA-5357801	5.966868e-06	5.224
Apoptosis	R-HSA-109581	1.010072e-05	4.996
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.396797e-05	4.855
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.508045e-05	4.601
Cellular Senescence	R-HSA-2559583	3.039749e-05	4.517
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	3.867106e-05	4.413
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	4.417788e-05	4.355
Mitotic Prometaphase	R-HSA-68877	4.603012e-05	4.337
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	7.326411e-05	4.135
Signaling by Hippo	R-HSA-2028269	7.634363e-05	4.117
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	7.326411e-05	4.135
Nuclear Envelope Breakdown	R-HSA-2980766	7.864561e-05	4.104
Signal Transduction	R-HSA-162582	9.062626e-05	4.043
Chromatin organization	R-HSA-4839726	1.263613e-04	3.898
Activation of BAD and translocation to mitochondria	R-HSA-111447	1.557285e-04	3.808
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.557285e-04	3.808
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.470293e-04	3.833
Mitotic Anaphase	R-HSA-68882	1.671369e-04	3.777
Activation of BH3-only proteins	R-HSA-114452	1.658990e-04	3.780
ChREBP activates metabolic gene expression	R-HSA-163765	1.420558e-04	3.848
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.808797e-04	3.743
SWI/SNF chromatin remodelers	R-HSA-9932451	2.119572e-04	3.674
ATP-dependent chromatin remodelers	R-HSA-9932444	2.119572e-04	3.674
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.306374e-04	3.637
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.058897e-04	3.514
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.248037e-04	3.488
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.423321e-04	3.466
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.552770e-04	3.449
Epigenetic regulation of gene expression	R-HSA-212165	3.986667e-04	3.399
Regulation of PTEN gene transcription	R-HSA-8943724	4.073695e-04	3.390
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.288571e-04	3.368
Cell Cycle Checkpoints	R-HSA-69620	4.666500e-04	3.331
MITF-M-regulated melanocyte development	R-HSA-9730414	5.397150e-04	3.268
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	8.629834e-04	3.064
Regulation of localization of FOXO transcription factors	R-HSA-9614399	9.326631e-04	3.030
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	9.326508e-04	3.030
Diseases of mitotic cell cycle	R-HSA-9675126	1.002460e-03	2.999
G2/M DNA damage checkpoint	R-HSA-69473	9.667359e-04	3.015
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.213557e-03	2.916
Chromatin modifying enzymes	R-HSA-3247509	1.194125e-03	2.923
Cellular response to heat stress	R-HSA-3371556	1.289802e-03	2.889
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.459562e-03	2.836
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.776178e-03	2.751
mTORC1-mediated signalling	R-HSA-166208	1.887249e-03	2.724
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.521399e-03	2.598
Mitotic Prophase	R-HSA-68875	2.579699e-03	2.588
SARS-CoV-1-host interactions	R-HSA-9692914	3.017135e-03	2.520
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	3.130101e-03	2.504
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	3.247668e-03	2.488
Mitotic Spindle Checkpoint	R-HSA-69618	3.555559e-03	2.449
Gene expression (Transcription)	R-HSA-74160	3.675105e-03	2.435
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.885081e-03	2.411
Apoptosis induced DNA fragmentation	R-HSA-140342	3.885081e-03	2.411
Regulation of MECP2 expression and activity	R-HSA-9022692	4.144505e-03	2.383
Oxidative Stress Induced Senescence	R-HSA-2559580	4.255693e-03	2.371
Transcriptional regulation by RUNX1	R-HSA-8878171	4.392307e-03	2.357
Transcriptional Regulation by TP53	R-HSA-3700989	4.861840e-03	2.313
PKMTs methylate histone lysines	R-HSA-3214841	5.231691e-03	2.281
Signaling by NTRK1 (TRKA)	R-HSA-187037	5.314321e-03	2.275
Intrinsic Pathway for Apoptosis	R-HSA-109606	5.353650e-03	2.271
NGF-stimulated transcription	R-HSA-9031628	5.373497e-03	2.270
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	5.823473e-03	2.235
Nuclear import of Rev protein	R-HSA-180746	5.679580e-03	2.246
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	5.852925e-03	2.233
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.347019e-03	2.197
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	6.595347e-03	2.181
MTOR signalling	R-HSA-165159	6.868376e-03	2.163
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	6.490193e-03	2.188
Mitotic Telophase/Cytokinesis	R-HSA-68884	7.004535e-03	2.155
Deubiquitination	R-HSA-5688426	7.123749e-03	2.147
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	7.419343e-03	2.130
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	8.353225e-03	2.078
Cohesin Loading onto Chromatin	R-HSA-2470946	8.353225e-03	2.078
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	8.256890e-03	2.083
Vpr-mediated nuclear import of PICs	R-HSA-180910	8.762534e-03	2.057
mRNA 3'-end processing	R-HSA-72187	8.728093e-03	2.059
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	8.411596e-03	2.075
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	8.416996e-03	2.075
Amplification of signal from the kinetochores	R-HSA-141424	8.416996e-03	2.075
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	8.256890e-03	2.083
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	8.762534e-03	2.057
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	9.107199e-03	2.041
RNA Polymerase II Transcription Termination	R-HSA-73856	9.355974e-03	2.029
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	9.619499e-03	2.017
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	9.619499e-03	2.017
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.099918e-02	1.959
Diseases of Telomere Maintenance	R-HSA-9673013	1.099918e-02	1.959
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.099918e-02	1.959
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.099918e-02	1.959
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.099918e-02	1.959
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.099918e-02	1.959
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.099918e-02	1.959
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.091516e-02	1.962
mRNA Splicing - Major Pathway	R-HSA-72163	1.137073e-02	1.944
Transcriptional regulation by small RNAs	R-HSA-5578749	1.180800e-02	1.928
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.180800e-02	1.928
IPs transport between nucleus and cytosol	R-HSA-1855170	1.283670e-02	1.892
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.295234e-02	1.888
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.297256e-02	1.887
Interactions of Rev with host cellular proteins	R-HSA-177243	1.297256e-02	1.887
Signaling by NTRKs	R-HSA-166520	1.329604e-02	1.876
NRAGE signals death through JNK	R-HSA-193648	1.351200e-02	1.869
ALK mutants bind TKIs	R-HSA-9700645	1.534973e-02	1.814
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.471206e-02	1.832
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.497012e-02	1.825
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.534973e-02	1.814
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.471206e-02	1.832
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.662155e-02	1.779
Cell-extracellular matrix interactions	R-HSA-446353	1.777950e-02	1.750
IRS activation	R-HSA-74713	1.816346e-02	1.741
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.816346e-02	1.741
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.816346e-02	1.741
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.816346e-02	1.741
mRNA Splicing	R-HSA-72172	2.014283e-02	1.696
Regulation of endogenous retroelements	R-HSA-9842860	1.850387e-02	1.733
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.896961e-02	1.722
Josephin domain DUBs	R-HSA-5689877	1.990813e-02	1.701
Separation of Sister Chromatids	R-HSA-2467813	1.892807e-02	1.723
G2/M Checkpoints	R-HSA-69481	1.861356e-02	1.730
Neurexins and neuroligins	R-HSA-6794361	2.162971e-02	1.665
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.199336e-02	1.658
SARS-CoV-2-host interactions	R-HSA-9705683	2.340824e-02	1.631
Breakdown of the nuclear lamina	R-HSA-352238	2.351416e-02	1.629
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.385858e-02	1.622
tRNA processing in the nucleus	R-HSA-6784531	2.409178e-02	1.618
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	2.561878e-02	1.591
Disorders of Developmental Biology	R-HSA-9675151	2.589701e-02	1.587
MITF-M-dependent gene expression	R-HSA-9856651	2.660891e-02	1.575
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.600269e-02	1.585
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.589701e-02	1.587
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.589701e-02	1.587
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	2.561878e-02	1.591
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.589701e-02	1.587
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.715020e-02	1.566
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.803283e-02	1.552
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.819614e-02	1.550
p75 NTR receptor-mediated signalling	R-HSA-193704	2.926467e-02	1.534
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.031335e-02	1.518
Transcriptional Regulation by E2F6	R-HSA-8953750	3.031335e-02	1.518
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.031335e-02	1.518
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.120726e-02	1.506
Activation of RAC1	R-HSA-428540	3.130630e-02	1.504
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.447532e-02	1.462
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.606295e-02	1.443
Estrogen-dependent gene expression	R-HSA-9018519	3.550451e-02	1.450
Oncogenic MAPK signaling	R-HSA-6802957	3.424367e-02	1.465
TGFBR3 expression	R-HSA-9839394	3.684637e-02	1.434
ISG15 antiviral mechanism	R-HSA-1169408	3.297993e-02	1.482
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.447532e-02	1.462
Cellular responses to stress	R-HSA-2262752	3.316151e-02	1.479
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.573227e-02	1.447
Protein-protein interactions at synapses	R-HSA-6794362	3.424367e-02	1.465
Death Receptor Signaling	R-HSA-73887	3.290261e-02	1.483
Transcriptional Regulation by VENTX	R-HSA-8853884	3.737871e-02	1.427
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.737871e-02	1.427
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.752461e-02	1.426
Disorders of Nervous System Development	R-HSA-9697154	3.818359e-02	1.418
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	3.818359e-02	1.418
Pervasive developmental disorders	R-HSA-9005895	3.818359e-02	1.418
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	3.818359e-02	1.418
RUNX3 regulates NOTCH signaling	R-HSA-8941856	3.818359e-02	1.418
AKT phosphorylates targets in the cytosol	R-HSA-198323	3.818359e-02	1.418
Cellular responses to stimuli	R-HSA-8953897	3.969425e-02	1.401
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	3.970434e-02	1.401
Regulation of TP53 Expression	R-HSA-6804754	3.973230e-02	1.401
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.973230e-02	1.401
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	3.999904e-02	1.398
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	4.470771e-02	1.350
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	4.585721e-02	1.339
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.585721e-02	1.339
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.585721e-02	1.339
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	4.120182e-02	1.385
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.079732e-02	1.389
Activation of PUMA and translocation to mitochondria	R-HSA-139915	4.470771e-02	1.350
PIP3 activates AKT signaling	R-HSA-1257604	4.024835e-02	1.395
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.585721e-02	1.339
Membrane Trafficking	R-HSA-199991	4.543942e-02	1.343
Intracellular signaling by second messengers	R-HSA-9006925	4.455498e-02	1.351
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	4.426026e-02	1.354
Uptake and function of diphtheria toxin	R-HSA-5336415	4.470771e-02	1.350
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.725883e-02	1.326
Viral Messenger RNA Synthesis	R-HSA-168325	4.791724e-02	1.320
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.837990e-02	1.315
Transcriptional regulation by RUNX3	R-HSA-8878159	4.838525e-02	1.315
Oncogene Induced Senescence	R-HSA-2559585	4.949556e-02	1.305
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	5.902720e-02	1.229
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	5.626947e-02	1.250
Signaling by MRAS-complex mutants	R-HSA-9660537	5.626947e-02	1.250
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	5.626947e-02	1.250
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	5.432543e-02	1.265
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.432543e-02	1.265
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.932223e-02	1.227
Nucleosome assembly	R-HSA-774815	5.963054e-02	1.225
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	5.963054e-02	1.225
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	5.582675e-02	1.253
Loss of Nlp from mitotic centrosomes	R-HSA-380259	5.582675e-02	1.253
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	5.721228e-02	1.243
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	5.129020e-02	1.290
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.432543e-02	1.265
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	5.963054e-02	1.225
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	5.421761e-02	1.266
RNA Polymerase II Transcription	R-HSA-73857	5.660730e-02	1.247
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	5.582675e-02	1.253
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	5.963054e-02	1.225
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.177171e-02	1.286
RUNX2 regulates bone development	R-HSA-8941326	5.473586e-02	1.262
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	5.626947e-02	1.250
Gene Silencing by RNA	R-HSA-211000	5.121858e-02	1.291
SARS-CoV-1 Infection	R-HSA-9678108	5.678074e-02	1.246
Mitotic G1 phase and G1/S transition	R-HSA-453279	6.166109e-02	1.210
DCC mediated attractive signaling	R-HSA-418885	6.357931e-02	1.197
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	6.454898e-02	1.190
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	6.490224e-02	1.188
Centrosome maturation	R-HSA-380287	6.545548e-02	1.184
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	6.598101e-02	1.181
S Phase	R-HSA-69242	6.756026e-02	1.170
GP1b-IX-V activation signalling	R-HSA-430116	6.909760e-02	1.161
AURKA Activation by TPX2	R-HSA-8854518	6.922035e-02	1.160
PTEN Regulation	R-HSA-6807070	6.944909e-02	1.158
Chromosome Maintenance	R-HSA-73886	6.955396e-02	1.158
UCH proteinases	R-HSA-5689603	6.985148e-02	1.156
Loss of Function of TP53 in Cancer	R-HSA-9723907	7.515074e-02	1.124
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	7.515074e-02	1.124
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	7.515074e-02	1.124
Regulation of gap junction activity	R-HSA-191650	8.084557e-02	1.092
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	8.084557e-02	1.092
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	8.084557e-02	1.092
MET activates RAP1 and RAC1	R-HSA-8875555	8.311645e-02	1.080
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	7.360338e-02	1.133
Attenuation phase	R-HSA-3371568	7.904659e-02	1.102
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.904659e-02	1.102
snRNP Assembly	R-HSA-191859	8.402855e-02	1.076
Metabolism of non-coding RNA	R-HSA-194441	8.402855e-02	1.076
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	8.325265e-02	1.080
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	7.097376e-02	1.149
ESR-mediated signaling	R-HSA-8939211	7.890287e-02	1.103
Activation of NOXA and translocation to mitochondria	R-HSA-111448	8.084557e-02	1.092
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	8.437631e-02	1.074
TP53 Regulates Metabolic Genes	R-HSA-5628897	8.260830e-02	1.083
G alpha (12/13) signalling events	R-HSA-416482	7.919926e-02	1.101
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	8.240046e-02	1.084
DNA Double Strand Break Response	R-HSA-5693606	7.410069e-02	1.130
Late Phase of HIV Life Cycle	R-HSA-162599	8.309712e-02	1.080
Signal attenuation	R-HSA-74749	8.311645e-02	1.080
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.415285e-02	1.075
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	8.084557e-02	1.092
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.360338e-02	1.133
Diseases of programmed cell death	R-HSA-9645723	8.325265e-02	1.080
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	7.721237e-02	1.112
Nervous system development	R-HSA-9675108	8.443784e-02	1.073
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	8.752207e-02	1.058
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	8.835918e-02	1.054
Regulation of necroptotic cell death	R-HSA-5675482	8.845942e-02	1.053
CD209 (DC-SIGN) signaling	R-HSA-5621575	8.875061e-02	1.052
Neurodegenerative Diseases	R-HSA-8863678	8.875061e-02	1.052
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	8.875061e-02	1.052
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	8.899578e-02	1.051
Signaling by ALK in cancer	R-HSA-9700206	8.899578e-02	1.051
Metabolism of RNA	R-HSA-8953854	9.300489e-02	1.031
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.462152e-02	1.024
HSF1-dependent transactivation	R-HSA-3371571	9.546948e-02	1.020
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.587158e-02	1.018
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.587158e-02	1.018
HIV Life Cycle	R-HSA-162587	9.880705e-02	1.005
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.007986e-01	0.997
Glycolysis	R-HSA-70171	1.009037e-01	0.996
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.025314e-01	0.989
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.446580e-01	0.840
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	R-HSA-73930	2.089453e-01	0.680
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.089453e-01	0.680
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.089453e-01	0.680
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	1.046998e-01	0.980
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.046998e-01	0.980
G2 Phase	R-HSA-68911	1.046998e-01	0.980
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.684043e-01	0.571
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	2.684043e-01	0.571
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.684043e-01	0.571
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.684043e-01	0.571
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.684043e-01	0.571
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	2.684043e-01	0.571
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.684043e-01	0.571
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.684043e-01	0.571
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.684043e-01	0.571
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	2.684043e-01	0.571
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.684043e-01	0.571
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	2.684043e-01	0.571
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.684043e-01	0.571
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.684043e-01	0.571
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	2.684043e-01	0.571
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.684043e-01	0.571
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	1.143802e-01	0.942
Condensation of Prometaphase Chromosomes	R-HSA-2514853	1.143802e-01	0.942
MECP2 regulates transcription factors	R-HSA-9022707	1.844496e-01	0.734
Displacement of DNA glycosylase by APEX1	R-HSA-110357	1.844496e-01	0.734
IFNG signaling activates MAPKs	R-HSA-9732724	1.844496e-01	0.734
SOS-mediated signalling	R-HSA-112412	1.844496e-01	0.734
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	1.844496e-01	0.734
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	1.844496e-01	0.734
FasL/ CD95L signaling	R-HSA-75157	3.233973e-01	0.490
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.233973e-01	0.490
Defective MMACHC causes MAHCC	R-HSA-3359474	3.233973e-01	0.490
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	3.233973e-01	0.490
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.233973e-01	0.490
MET activates PTPN11	R-HSA-8865999	3.233973e-01	0.490
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.233973e-01	0.490
RUNX3 regulates p14-ARF	R-HSA-8951936	1.314384e-01	0.881
Type I hemidesmosome assembly	R-HSA-446107	2.126619e-01	0.672
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	2.126619e-01	0.672
MET receptor recycling	R-HSA-8875656	2.126619e-01	0.672
Myoclonic epilepsy of Lafora	R-HSA-3785653	2.126619e-01	0.672
Formation of annular gap junctions	R-HSA-196025	2.126619e-01	0.672
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	1.493181e-01	0.826
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.209012e-01	0.918
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.679215e-01	0.775
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.412427e-01	0.618
Gap junction degradation	R-HSA-190873	2.412427e-01	0.618
WNT mediated activation of DVL	R-HSA-201688	2.412427e-01	0.618
Calcineurin activates NFAT	R-HSA-2025928	2.412427e-01	0.618
HCN channels	R-HSA-1296061	3.742597e-01	0.427
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	3.742597e-01	0.427
Inhibition of TSC complex formation by PKB	R-HSA-165181	3.742597e-01	0.427
PLCG1 events in ERBB2 signaling	R-HSA-1251932	3.742597e-01	0.427
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	3.742597e-01	0.427
GRB7 events in ERBB2 signaling	R-HSA-1306955	3.742597e-01	0.427
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	1.871514e-01	0.728
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.484017e-01	0.829
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.484017e-01	0.829
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	1.484017e-01	0.829
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	2.699774e-01	0.569
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.192838e-01	0.923
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.192838e-01	0.923
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.069130e-01	0.684
Phosphorylation of the APC/C	R-HSA-176412	2.069130e-01	0.684
HIV elongation arrest and recovery	R-HSA-167287	1.304293e-01	0.885
Pausing and recovery of HIV elongation	R-HSA-167290	1.304293e-01	0.885
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.054893e-01	0.977
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.271142e-01	0.644
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	2.986816e-01	0.525
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	4.213014e-01	0.375
FLT3 signaling by CBL mutants	R-HSA-9706377	4.213014e-01	0.375
G1/S-Specific Transcription	R-HSA-69205	1.240861e-01	0.906
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	1.240861e-01	0.906
HSF1 activation	R-HSA-3371511	1.240861e-01	0.906
Activation of the pre-replicative complex	R-HSA-68962	1.540512e-01	0.812
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.540512e-01	0.812
EGFR downregulation	R-HSA-182971	1.664817e-01	0.779
Deadenylation of mRNA	R-HSA-429947	2.094614e-01	0.679
TRAF6 mediated NF-kB activation	R-HSA-933542	2.094614e-01	0.679
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.271977e-01	0.485
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.684854e-01	0.571
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.684854e-01	0.571
GAB1 signalosome	R-HSA-180292	2.684854e-01	0.571
RNA Polymerase III Transcription Termination	R-HSA-73980	2.684854e-01	0.571
HDACs deacetylate histones	R-HSA-3214815	1.249096e-01	0.903
Signaling by EGFR in Cancer	R-HSA-1643713	2.422975e-01	0.616
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.422975e-01	0.616
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.894912e-01	0.538
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	3.553920e-01	0.449
Leading Strand Synthesis	R-HSA-69109	3.553920e-01	0.449
Polymerase switching	R-HSA-69091	3.553920e-01	0.449
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.553920e-01	0.449
Scavenging by Class F Receptors	R-HSA-3000484	3.553920e-01	0.449
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	4.648092e-01	0.333
Nef Mediated CD8 Down-regulation	R-HSA-182218	4.648092e-01	0.333
IkBA variant leads to EDA-ID	R-HSA-5603029	4.648092e-01	0.333
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	4.648092e-01	0.333
PDE3B signalling	R-HSA-165160	4.648092e-01	0.333
PKB-mediated events	R-HSA-109703	4.648092e-01	0.333
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	4.648092e-01	0.333
Noncanonical activation of NOTCH3	R-HSA-9017802	4.648092e-01	0.333
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	4.648092e-01	0.333
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	4.648092e-01	0.333
Defective CSF2RA causes SMDP4	R-HSA-5688890	4.648092e-01	0.333
Defective CSF2RB causes SMDP5	R-HSA-5688849	4.648092e-01	0.333
RAF activation	R-HSA-5673000	2.197417e-01	0.658
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	1.497515e-01	0.825
RNA Polymerase I Transcription Termination	R-HSA-73863	2.591323e-01	0.586
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.001123e-01	0.699
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	1.344195e-01	0.872
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.761855e-01	0.559
Formation of the Early Elongation Complex	R-HSA-113418	2.761855e-01	0.559
PRC2 methylates histones and DNA	R-HSA-212300	2.481156e-01	0.605
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.317676e-01	0.479
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.626412e-01	0.581
Translation initiation complex formation	R-HSA-72649	2.150035e-01	0.668
Signaling downstream of RAS mutants	R-HSA-9649948	2.496835e-01	0.603
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.496835e-01	0.603
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.496835e-01	0.603
mRNA Splicing - Minor Pathway	R-HSA-72165	2.496835e-01	0.603
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	3.529030e-01	0.452
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	4.103833e-01	0.387
Removal of the Flap Intermediate	R-HSA-69166	4.103833e-01	0.387
Retrograde neurotrophin signalling	R-HSA-177504	4.103833e-01	0.387
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.050484e-01	0.297
Signaling by LTK in cancer	R-HSA-9842640	5.050484e-01	0.297
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.050484e-01	0.297
Erythropoietin activates STAT5	R-HSA-9027283	5.050484e-01	0.297
Autointegration results in viral DNA circles	R-HSA-177539	5.050484e-01	0.297
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	5.050484e-01	0.297
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.050484e-01	0.297
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	5.050484e-01	0.297
Ribosomal scanning and start codon recognition	R-HSA-72702	2.374976e-01	0.624
Notch-HLH transcription pathway	R-HSA-350054	3.739544e-01	0.427
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.072381e-01	0.513
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	3.072381e-01	0.513
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	2.607120e-01	0.584
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	2.141647e-01	0.669
Erythropoietin activates RAS	R-HSA-9027284	4.370090e-01	0.360
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	4.370090e-01	0.360
Interleukin receptor SHC signaling	R-HSA-912526	3.948669e-01	0.404
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	3.948669e-01	0.404
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	3.948669e-01	0.404
Signaling by RAF1 mutants	R-HSA-9656223	3.375476e-01	0.472
Formation of RNA Pol II elongation complex	R-HSA-112382	3.292575e-01	0.482
Striated Muscle Contraction	R-HSA-390522	3.807581e-01	0.419
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.428822e-01	0.465
Meiotic synapsis	R-HSA-1221632	3.428822e-01	0.465
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.360782e-01	0.360
Nuclear Receptor transcription pathway	R-HSA-383280	3.593103e-01	0.445
EPHA-mediated growth cone collapse	R-HSA-3928663	4.761904e-01	0.322
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	4.087517e-01	0.389
Activation of AMPK downstream of NMDARs	R-HSA-9619483	4.957455e-01	0.305
Signaling by Erythropoietin	R-HSA-9006335	5.149275e-01	0.288
DNA methylation	R-HSA-5334118	5.149275e-01	0.288
Late endosomal microautophagy	R-HSA-9615710	5.149275e-01	0.288
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	5.001383e-01	0.301
Orc1 removal from chromatin	R-HSA-68949	5.032828e-01	0.298
Transcriptional Regulation by MECP2	R-HSA-8986944	1.652768e-01	0.782
Transcription of the HIV genome	R-HSA-167172	3.835997e-01	0.416
RNA Polymerase III Transcription	R-HSA-74158	1.240861e-01	0.906
Signaling by EGFR	R-HSA-177929	1.329359e-01	0.876
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	4.131903e-01	0.384
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	4.131903e-01	0.384
Nucleotide Excision Repair	R-HSA-5696398	2.101310e-01	0.678
HIV Transcription Elongation	R-HSA-167169	3.072381e-01	0.513
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.441645e-01	0.841
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	1.656193e-01	0.781
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	1.656193e-01	0.781
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	4.131903e-01	0.384
RNA Polymerase III Transcription Initiation	R-HSA-76046	3.107746e-01	0.508
HCMV Early Events	R-HSA-9609690	1.792474e-01	0.747
Adipogenesis	R-HSA-9843745	1.196838e-01	0.922
mRNA Capping	R-HSA-72086	5.149275e-01	0.288
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.493181e-01	0.826
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.094614e-01	0.679
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	3.529030e-01	0.452
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.884317e-01	0.725
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	3.285305e-01	0.483
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	4.562905e-01	0.341
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.149275e-01	0.288
Telomere Maintenance	R-HSA-157579	4.684449e-01	0.329
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	2.197417e-01	0.658
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	3.072381e-01	0.513
Aggrephagy	R-HSA-9646399	1.656193e-01	0.781
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	4.292408e-01	0.367
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.106086e-01	0.508
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.107746e-01	0.508
Processive synthesis on the lagging strand	R-HSA-69183	4.370090e-01	0.360
G0 and Early G1	R-HSA-1538133	1.792923e-01	0.746
Nephrin family interactions	R-HSA-373753	3.106086e-01	0.508
TRAF6 mediated IRF7 activation	R-HSA-933541	2.626412e-01	0.581
Resolution of D-Loop Structures	R-HSA-5693537	3.807581e-01	0.419
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.871514e-01	0.728
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.684854e-01	0.571
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	3.632560e-01	0.440
MAP2K and MAPK activation	R-HSA-5674135	3.375476e-01	0.472
G1 Phase	R-HSA-69236	1.169343e-01	0.932
Cyclin D associated events in G1	R-HSA-69231	1.169343e-01	0.932
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.529030e-01	0.452
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.126619e-01	0.672
Downregulation of ERBB4 signaling	R-HSA-1253288	2.126619e-01	0.672
PI3K/AKT activation	R-HSA-198203	2.699774e-01	0.569
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.922299e-01	0.534
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	3.739544e-01	0.427
DNA strand elongation	R-HSA-69190	3.457340e-01	0.461
WNT5A-dependent internalization of FZD4	R-HSA-5099900	4.629662e-01	0.334
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	4.761904e-01	0.322
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	5.126866e-01	0.290
Signaling by Nuclear Receptors	R-HSA-9006931	2.486080e-01	0.604
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	3.085063e-01	0.511
Chaperone Mediated Autophagy	R-HSA-9613829	1.080582e-01	0.966
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.001123e-01	0.699
RNA Polymerase I Transcription	R-HSA-73864	1.415749e-01	0.849
Signaling by RAS mutants	R-HSA-6802949	2.496835e-01	0.603
Synthesis of DNA	R-HSA-69239	4.517425e-01	0.345
Regulation of TP53 Activity	R-HSA-5633007	1.649449e-01	0.783
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	2.746013e-01	0.561
Generation of second messenger molecules	R-HSA-202433	3.072381e-01	0.513
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.133302e-01	0.504
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	4.711733e-01	0.327
G1/S Transition	R-HSA-69206	4.131903e-01	0.384
FOXO-mediated transcription	R-HSA-9614085	1.586926e-01	0.799
VLDLR internalisation and degradation	R-HSA-8866427	1.314384e-01	0.881
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	2.126619e-01	0.672
NF-kB is activated and signals survival	R-HSA-209560	3.271977e-01	0.485
E2F mediated regulation of DNA replication	R-HSA-113510	2.894912e-01	0.538
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	3.553920e-01	0.449
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	4.648092e-01	0.333
COPI-mediated anterograde transport	R-HSA-6807878	3.285305e-01	0.483
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	1.780407e-01	0.749
Interleukin-2 signaling	R-HSA-9020558	2.986816e-01	0.525
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	4.562905e-01	0.341
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.208105e-01	0.376
Activation of HOX genes during differentiation	R-HSA-5619507	4.208105e-01	0.376
DNA Replication Pre-Initiation	R-HSA-69002	4.722492e-01	0.326
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.192838e-01	0.923
Repression of WNT target genes	R-HSA-4641265	3.553920e-01	0.449
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.922299e-01	0.534
Clathrin-mediated endocytosis	R-HSA-8856828	1.993062e-01	0.700
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.935512e-01	0.713
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.154225e-01	0.667
Switching of origins to a post-replicative state	R-HSA-69052	3.020157e-01	0.520
Listeria monocytogenes entry into host cells	R-HSA-8876384	3.529030e-01	0.452
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.850481e-01	0.545
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.301612e-01	0.886
Post-transcriptional silencing by small RNAs	R-HSA-426496	4.213014e-01	0.375
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.476664e-01	0.606
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	3.271977e-01	0.485
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.155900e-01	0.381
Defective pyroptosis	R-HSA-9710421	3.680764e-01	0.434
Regulation of TP53 Degradation	R-HSA-6804757	4.328189e-01	0.364
Interleukin-2 family signaling	R-HSA-451927	3.072381e-01	0.513
Signaling by ERBB2	R-HSA-1227986	4.387806e-01	0.358
Processing of DNA double-strand break ends	R-HSA-5693607	3.942436e-01	0.404
Recycling pathway of L1	R-HSA-437239	1.434720e-01	0.843
Extra-nuclear estrogen signaling	R-HSA-9009391	3.795332e-01	0.421
Maternal to zygotic transition (MZT)	R-HSA-9816359	5.045510e-01	0.297
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	4.370090e-01	0.360
DNA Double-Strand Break Repair	R-HSA-5693532	1.291614e-01	0.889
Homology Directed Repair	R-HSA-5693538	2.382108e-01	0.623
Frs2-mediated activation	R-HSA-170968	1.493181e-01	0.826
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	2.699774e-01	0.569
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	3.282278e-01	0.484
HCMV Infection	R-HSA-9609646	3.666129e-01	0.436
Signaling by FLT3 fusion proteins	R-HSA-9703465	4.562905e-01	0.341
Assembly of the pre-replicative complex	R-HSA-68867	4.139740e-01	0.383
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.301612e-01	0.886
Transcriptional activation of p53 responsive genes	R-HSA-69560	3.742597e-01	0.427
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	3.742597e-01	0.427
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	3.742597e-01	0.427
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	2.476664e-01	0.606
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.422975e-01	0.616
Aryl hydrocarbon receptor signalling	R-HSA-8937144	4.648092e-01	0.333
Deadenylation-dependent mRNA decay	R-HSA-429914	2.725541e-01	0.565
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.811770e-01	0.419
Circadian clock	R-HSA-9909396	3.738544e-01	0.427
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.069130e-01	0.684
Generic Transcription Pathway	R-HSA-212436	1.355467e-01	0.868
Myogenesis	R-HSA-525793	1.086101e-01	0.964
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.271977e-01	0.485
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.387806e-01	0.358
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.387806e-01	0.358
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.387806e-01	0.358
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.387806e-01	0.358
Regulated Necrosis	R-HSA-5218859	2.470880e-01	0.607
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	4.658623e-01	0.332
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	4.658623e-01	0.332
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.949396e-01	0.305
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	2.894912e-01	0.538
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.632560e-01	0.440
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.576073e-01	0.340
p75NTR signals via NF-kB	R-HSA-193639	4.370090e-01	0.360
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.949396e-01	0.305
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.149275e-01	0.288
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.267250e-01	0.370
MAP kinase activation	R-HSA-450294	1.767800e-01	0.753
Prolonged ERK activation events	R-HSA-169893	2.069130e-01	0.684
Formation of editosomes by ADAR proteins	R-HSA-77042	1.446580e-01	0.840
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.089453e-01	0.680
Manipulation of host energy metabolism	R-HSA-9636667	2.089453e-01	0.680
Transport of connexins along the secretory pathway	R-HSA-190827	2.089453e-01	0.680
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	1.046998e-01	0.980
mRNA Editing: A to I Conversion	R-HSA-75064	2.684043e-01	0.571
C6 deamination of adenosine	R-HSA-75102	2.684043e-01	0.571
Signalling to ERK5	R-HSA-198765	2.684043e-01	0.571
Regulation of PTEN localization	R-HSA-8948747	1.844496e-01	0.734
MET interacts with TNS proteins	R-HSA-8875513	3.233973e-01	0.490
Unwinding of DNA	R-HSA-176974	2.412427e-01	0.618
Inactivation of CDC42 and RAC1	R-HSA-428543	2.412427e-01	0.618
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.271142e-01	0.644
Reelin signalling pathway	R-HSA-8866376	4.213014e-01	0.375
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.213014e-01	0.375
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.935512e-01	0.713
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	3.271977e-01	0.485
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.059493e-01	0.686
CDC6 association with the ORC:origin complex	R-HSA-68689	4.648092e-01	0.333
Synthesis of PS	R-HSA-1483101	4.648092e-01	0.333
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	5.050484e-01	0.297
G2/M DNA replication checkpoint	R-HSA-69478	5.050484e-01	0.297
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	4.370090e-01	0.360
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	4.155900e-01	0.381
Metalloprotease DUBs	R-HSA-5689901	4.562905e-01	0.341
MET promotes cell motility	R-HSA-8875878	4.668623e-01	0.331
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.338468e-01	0.363
Golgi-to-ER retrograde transport	R-HSA-8856688	4.878254e-01	0.312
Autophagy	R-HSA-9612973	3.863030e-01	0.413
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.980527e-01	0.526
HIV Infection	R-HSA-162906	1.663406e-01	0.779
Interleukin-17 signaling	R-HSA-448424	2.686853e-01	0.571
DNA Repair	R-HSA-73894	2.347614e-01	0.629
Regulation of PD-L1(CD274) expression	R-HSA-9909648	4.238018e-01	0.373
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.234476e-01	0.373
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	4.524735e-01	0.344
HATs acetylate histones	R-HSA-3214847	2.464930e-01	0.608
Selective autophagy	R-HSA-9663891	2.320688e-01	0.634
Spry regulation of FGF signaling	R-HSA-1295596	4.370090e-01	0.360
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	4.620116e-01	0.335
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.582685e-01	0.446
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.314384e-01	0.881
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.943279e-01	0.306
Cell-Cell communication	R-HSA-1500931	3.194660e-01	0.496
Smooth Muscle Contraction	R-HSA-445355	2.040610e-01	0.690
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.756667e-01	0.560
Vesicle-mediated transport	R-HSA-5653656	3.572345e-01	0.447
Signaling by NOTCH1	R-HSA-1980143	1.274614e-01	0.895
MyD88-independent TLR4 cascade	R-HSA-166166	3.582685e-01	0.446
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.103919e-01	0.508
Rap1 signalling	R-HSA-392517	1.209012e-01	0.918
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.684854e-01	0.571
ERK/MAPK targets	R-HSA-198753	3.317676e-01	0.479
Acetylcholine regulates insulin secretion	R-HSA-399997	4.882050e-01	0.311
TRP channels	R-HSA-3295583	4.562905e-01	0.341
PI3K events in ERBB2 signaling	R-HSA-1963642	5.126866e-01	0.290
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.837020e-01	0.315
Macroautophagy	R-HSA-1632852	3.548127e-01	0.450
Cell junction organization	R-HSA-446728	4.682916e-01	0.329
Developmental Biology	R-HSA-1266738	3.072718e-01	0.512
Negative regulation of FLT3	R-HSA-9706369	2.069130e-01	0.684
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.935512e-01	0.713
Evasion by RSV of host interferon responses	R-HSA-9833109	3.282278e-01	0.484
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.499248e-01	0.347
Signaling by MET	R-HSA-6806834	3.825782e-01	0.417
Muscarinic acetylcholine receptors	R-HSA-390648	4.213014e-01	0.375
Signaling by LTK	R-HSA-9842663	3.553920e-01	0.449
Heme signaling	R-HSA-9707616	1.862397e-01	0.730
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.222855e-01	0.913
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	4.629662e-01	0.334
Glycogen storage diseases	R-HSA-3229121	5.126866e-01	0.290
Rab regulation of trafficking	R-HSA-9007101	4.463276e-01	0.350
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.488004e-01	0.457
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.488004e-01	0.457
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.488004e-01	0.457
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	2.761855e-01	0.559
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.934136e-01	0.533
Regulation of BACH1 activity	R-HSA-9708530	4.629662e-01	0.334
Acyl chain remodelling of PS	R-HSA-1482801	4.360782e-01	0.360
Host Interactions of HIV factors	R-HSA-162909	1.979834e-01	0.703
Regulation of NPAS4 gene expression	R-HSA-9768759	5.126866e-01	0.290
Cellular responses to mechanical stimuli	R-HSA-9855142	3.972963e-01	0.401
MyD88 dependent cascade initiated on endosome	R-HSA-975155	4.722492e-01	0.326
Signaling by NOTCH	R-HSA-157118	3.823775e-01	0.418
Ovarian tumor domain proteases	R-HSA-5689896	1.339462e-01	0.873
Zygotic genome activation (ZGA)	R-HSA-9819196	1.484017e-01	0.829
Oligomerization of connexins into connexons	R-HSA-190704	2.089453e-01	0.680
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.301612e-01	0.886
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.233973e-01	0.490
Cellular response to mitochondrial stress	R-HSA-9840373	2.412427e-01	0.618
ARMS-mediated activation	R-HSA-170984	2.412427e-01	0.618
NADE modulates death signalling	R-HSA-205025	3.742597e-01	0.427
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	3.742597e-01	0.427
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.271142e-01	0.644
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.213014e-01	0.375
Nuclear RNA decay	R-HSA-9930044	1.924571e-01	0.716
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.924571e-01	0.716
Signalling to p38 via RIT and RIN	R-HSA-187706	4.648092e-01	0.333
Integration of viral DNA into host genomic DNA	R-HSA-175567	5.050484e-01	0.297
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.884317e-01	0.725
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.584586e-01	0.800
Effects of PIP2 hydrolysis	R-HSA-114508	3.807581e-01	0.419
Mitochondrial biogenesis	R-HSA-1592230	2.304080e-01	0.638
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	4.882050e-01	0.311
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.840064e-01	0.416
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	4.169128e-01	0.380
Organelle biogenesis and maintenance	R-HSA-1852241	4.151736e-01	0.382
Signaling by NOTCH3	R-HSA-9012852	1.249096e-01	0.903
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.127607e-01	0.290
Semaphorin interactions	R-HSA-373755	3.211530e-01	0.493
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.756667e-01	0.560
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.387806e-01	0.358
Signaling by TGFBR3	R-HSA-9839373	2.496835e-01	0.603
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	4.155704e-01	0.381
FLT3 Signaling	R-HSA-9607240	3.223527e-01	0.492
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.295558e-01	0.888
Axon guidance	R-HSA-422475	2.068732e-01	0.684
Mitotic G2-G2/M phases	R-HSA-453274	2.710095e-01	0.567
Neurofascin interactions	R-HSA-447043	1.568540e-01	0.805
Histamine receptors	R-HSA-390650	3.233973e-01	0.490
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.699774e-01	0.569
Suppression of apoptosis	R-HSA-9635465	2.986816e-01	0.525
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.684449e-01	0.329
G2/M Transition	R-HSA-69275	4.355369e-01	0.361
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	1.933392e-01	0.714
DNA Damage Bypass	R-HSA-73893	4.590981e-01	0.338
Signaling by Interleukins	R-HSA-449147	2.315426e-01	0.635
L1CAM interactions	R-HSA-373760	3.206869e-01	0.494
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	2.684043e-01	0.571
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.412427e-01	0.618
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	2.699774e-01	0.569
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.213014e-01	0.375
CLEC7A/inflammasome pathway	R-HSA-5660668	4.648092e-01	0.333
PI5P Regulates TP53 Acetylation	R-HSA-6811555	3.831518e-01	0.417
RET signaling	R-HSA-8853659	2.481156e-01	0.605
Regulation of KIT signaling	R-HSA-1433559	4.103833e-01	0.387
CREB phosphorylation	R-HSA-199920	5.050484e-01	0.297
Cytokine Signaling in Immune system	R-HSA-1280215	4.955083e-01	0.305
Netrin-1 signaling	R-HSA-373752	1.169343e-01	0.932
Biotin transport and metabolism	R-HSA-196780	4.370090e-01	0.360
FLT3 signaling in disease	R-HSA-9682385	4.328189e-01	0.364
Glucose metabolism	R-HSA-70326	2.304080e-01	0.638
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.484017e-01	0.829
Plasma lipoprotein clearance	R-HSA-8964043	4.836074e-01	0.316
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	4.087517e-01	0.389
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	1.844496e-01	0.734
Respiratory syncytial virus genome replication	R-HSA-9834752	2.412427e-01	0.618
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.213014e-01	0.375
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	3.271977e-01	0.485
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	4.648092e-01	0.333
Signal regulatory protein family interactions	R-HSA-391160	4.103833e-01	0.387
Nef and signal transduction	R-HSA-164944	5.050484e-01	0.297
CREB3 factors activate genes	R-HSA-8874211	5.050484e-01	0.297
Inositol phosphate metabolism	R-HSA-1483249	1.789628e-01	0.747
RMTs methylate histone arginines	R-HSA-3214858	2.244477e-01	0.649
tRNA processing	R-HSA-72306	5.105754e-01	0.292
Signaling by PDGFR in disease	R-HSA-9671555	1.629758e-01	0.788
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	4.648092e-01	0.333
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	2.197417e-01	0.658
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	4.629662e-01	0.334
Sensory processing of sound	R-HSA-9659379	3.709302e-01	0.431
Uptake and function of anthrax toxins	R-HSA-5210891	5.126866e-01	0.290
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	4.648092e-01	0.333
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.050484e-01	0.297
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.470880e-01	0.607
Signaling by ALK	R-HSA-201556	4.836074e-01	0.316
OAS antiviral response	R-HSA-8983711	3.553920e-01	0.449
Unfolded Protein Response (UPR)	R-HSA-381119	4.455198e-01	0.351
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.329359e-01	0.876
SARS-CoV Infections	R-HSA-9679506	1.997014e-01	0.700
Regulation of beta-cell development	R-HSA-186712	1.585277e-01	0.800
SARS-CoV-2 Infection	R-HSA-9694516	1.431354e-01	0.844
Signaling by Leptin	R-HSA-2586552	2.699774e-01	0.569
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	3.831518e-01	0.417
Interleukin-12 signaling	R-HSA-9020591	1.274614e-01	0.895
Regulation of gene expression in beta cells	R-HSA-210745	2.934136e-01	0.533
Uptake and actions of bacterial toxins	R-HSA-5339562	5.032828e-01	0.298
Interleukin-37 signaling	R-HSA-9008059	3.107746e-01	0.508
Interleukin-12 family signaling	R-HSA-447115	2.230461e-01	0.652
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	5.164351e-01	0.287
VEGFR2 mediated vascular permeability	R-HSA-5218920	5.164351e-01	0.287
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.164351e-01	0.287
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.164351e-01	0.287
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	5.318269e-01	0.274
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	5.324796e-01	0.274
HIV Transcription Initiation	R-HSA-167161	5.324796e-01	0.274
RNA Polymerase II Transcription Initiation	R-HSA-75953	5.324796e-01	0.274
Negative regulation of MAPK pathway	R-HSA-5675221	5.324796e-01	0.274
Signaling by FGFR1 in disease	R-HSA-5655302	5.324796e-01	0.274
Signaling by VEGF	R-HSA-194138	5.330718e-01	0.273
Integration of energy metabolism	R-HSA-163685	5.335026e-01	0.273
Signaling by ERBB2 in Cancer	R-HSA-1227990	5.337117e-01	0.273
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.337117e-01	0.273
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	5.349036e-01	0.272
Regulation of CDH1 Expression and Function	R-HSA-9764265	5.349036e-01	0.272
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.363824e-01	0.271
PKA activation in glucagon signalling	R-HSA-164378	5.363824e-01	0.271
Mismatch Repair	R-HSA-5358508	5.363824e-01	0.271
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	5.363824e-01	0.271
Ephrin signaling	R-HSA-3928664	5.363824e-01	0.271
Polo-like kinase mediated events	R-HSA-156711	5.363824e-01	0.271
Nephron development	R-HSA-9831926	5.363824e-01	0.271
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	5.422644e-01	0.266
MET activates PI3K/AKT signaling	R-HSA-8851907	5.422644e-01	0.266
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	5.422644e-01	0.266
Recycling of eIF2:GDP	R-HSA-72731	5.422644e-01	0.266
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	5.422644e-01	0.266
PTK6 Expression	R-HSA-8849473	5.422644e-01	0.266
Nef Mediated CD4 Down-regulation	R-HSA-167590	5.422644e-01	0.266
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	5.422644e-01	0.266
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.422644e-01	0.266
TRIF-mediated programmed cell death	R-HSA-2562578	5.422644e-01	0.266
VLDL clearance	R-HSA-8964046	5.422644e-01	0.266
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	5.422644e-01	0.266
EPH-Ephrin signaling	R-HSA-2682334	5.430584e-01	0.265
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	5.434238e-01	0.265
Budding and maturation of HIV virion	R-HSA-162588	5.520772e-01	0.258
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	5.520772e-01	0.258
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	5.571809e-01	0.254
Regulation of signaling by CBL	R-HSA-912631	5.592720e-01	0.252
Impaired BRCA2 binding to PALB2	R-HSA-9709603	5.592720e-01	0.252
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	5.592720e-01	0.252
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	5.592720e-01	0.252
Signaling by FGFR2 IIIa TM	R-HSA-8851708	5.592720e-01	0.252
The NLRP3 inflammasome	R-HSA-844456	5.592720e-01	0.252
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.598234e-01	0.252
TNF signaling	R-HSA-75893	5.598234e-01	0.252
RNA Polymerase II Promoter Escape	R-HSA-73776	5.637484e-01	0.249
TBC/RABGAPs	R-HSA-8854214	5.637484e-01	0.249
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	5.637484e-01	0.249
Signaling by SCF-KIT	R-HSA-1433557	5.637484e-01	0.249
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	5.648060e-01	0.248
Signaling by ROBO receptors	R-HSA-376176	5.658094e-01	0.247
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	5.700063e-01	0.244
Toll-like Receptor Cascades	R-HSA-168898	5.738226e-01	0.241
RSK activation	R-HSA-444257	5.766841e-01	0.239
EGFR interacts with phospholipase C-gamma	R-HSA-212718	5.766841e-01	0.239
Regulation of NPAS4 mRNA translation	R-HSA-9768778	5.766841e-01	0.239
Activated NTRK2 signals through PI3K	R-HSA-9028335	5.766841e-01	0.239
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	5.766841e-01	0.239
Axonal growth inhibition (RHOA activation)	R-HSA-193634	5.766841e-01	0.239
Regulation by c-FLIP	R-HSA-3371378	5.766841e-01	0.239
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	5.766841e-01	0.239
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	5.766841e-01	0.239
Dimerization of procaspase-8	R-HSA-69416	5.766841e-01	0.239
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	5.766841e-01	0.239
SLC-mediated bile acid transport	R-HSA-9958517	5.766841e-01	0.239
Alpha-defensins	R-HSA-1462054	5.766841e-01	0.239
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	5.766841e-01	0.239
Sodium/Proton exchangers	R-HSA-425986	5.766841e-01	0.239
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	5.813428e-01	0.236
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	5.813428e-01	0.236
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	5.813428e-01	0.236
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	5.813428e-01	0.236
VxPx cargo-targeting to cilium	R-HSA-5620916	5.813428e-01	0.236
Glycogen synthesis	R-HSA-3322077	5.813428e-01	0.236
Negative regulation of MET activity	R-HSA-6807004	5.813428e-01	0.236
Signaling by NODAL	R-HSA-1181150	5.813428e-01	0.236
Protein hydroxylation	R-HSA-9629569	5.813428e-01	0.236
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	5.813428e-01	0.236
NoRC negatively regulates rRNA expression	R-HSA-427413	5.819307e-01	0.235
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.874843e-01	0.231
Assembly of the ORC complex at the origin of replication	R-HSA-68616	5.874843e-01	0.231
FGFR1 mutant receptor activation	R-HSA-1839124	5.874843e-01	0.231
Activation of ATR in response to replication stress	R-HSA-176187	5.874843e-01	0.231
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	5.874843e-01	0.231
Meiosis	R-HSA-1500620	5.895570e-01	0.229
MAPK6/MAPK4 signaling	R-HSA-5687128	5.895570e-01	0.229
Transcriptional regulation by RUNX2	R-HSA-8878166	5.905361e-01	0.229
Stimuli-sensing channels	R-HSA-2672351	5.932341e-01	0.227
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	5.938347e-01	0.226
DAG and IP3 signaling	R-HSA-1489509	5.938347e-01	0.226
Basigin interactions	R-HSA-210991	6.025884e-01	0.220
Lagging Strand Synthesis	R-HSA-69186	6.025884e-01	0.220
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.025884e-01	0.220
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	6.084072e-01	0.216
Regulation of TNFR1 signaling	R-HSA-5357905	6.084072e-01	0.216
Interleukin-21 signaling	R-HSA-9020958	6.085175e-01	0.216
CASP8 activity is inhibited	R-HSA-5218900	6.085175e-01	0.216
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.085175e-01	0.216
Lipophagy	R-HSA-9613354	6.085175e-01	0.216
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.085175e-01	0.216
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	6.085175e-01	0.216
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.085175e-01	0.216
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	6.085175e-01	0.216
p75NTR regulates axonogenesis	R-HSA-193697	6.085175e-01	0.216
mRNA Editing	R-HSA-75072	6.085175e-01	0.216
Regulation of signaling by NODAL	R-HSA-1433617	6.085175e-01	0.216
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.085175e-01	0.216
AKT phosphorylates targets in the nucleus	R-HSA-198693	6.085175e-01	0.216
Regulation of NPAS4 gene transcription	R-HSA-9768777	6.085175e-01	0.216
Regulation of CDH11 gene transcription	R-HSA-9762293	6.085175e-01	0.216
Interleukin-1 processing	R-HSA-448706	6.085175e-01	0.216
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.085175e-01	0.216
Regulated proteolysis of p75NTR	R-HSA-193692	6.085175e-01	0.216
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	6.085175e-01	0.216
Defects in biotin (Btn) metabolism	R-HSA-3323169	6.085175e-01	0.216
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	6.085175e-01	0.216
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	6.109870e-01	0.214
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	6.116272e-01	0.214
XBP1(S) activates chaperone genes	R-HSA-381038	6.116272e-01	0.214
TCF dependent signaling in response to WNT	R-HSA-201681	6.128721e-01	0.213
Kinesins	R-HSA-983189	6.129520e-01	0.213
Signaling by ERBB4	R-HSA-1236394	6.176825e-01	0.209
Signaling by FGFR in disease	R-HSA-1226099	6.176825e-01	0.209
NOD1/2 Signaling Pathway	R-HSA-168638	6.210429e-01	0.207
Mitophagy	R-HSA-5205647	6.210429e-01	0.207
Signaling by NOTCH2	R-HSA-1980145	6.210429e-01	0.207
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.230081e-01	0.206
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	6.230081e-01	0.206
Developmental Cell Lineages	R-HSA-9734767	6.233271e-01	0.205
IRS-related events triggered by IGF1R	R-HSA-2428928	6.256340e-01	0.204
MHC class II antigen presentation	R-HSA-2132295	6.272082e-01	0.203
Signaling by TGFB family members	R-HSA-9006936	6.332593e-01	0.198
ER to Golgi Anterograde Transport	R-HSA-199977	6.365986e-01	0.196
PERK regulates gene expression	R-HSA-381042	6.371078e-01	0.196
Signalling to ERKs	R-HSA-187687	6.371078e-01	0.196
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	6.379588e-01	0.195
DNA replication initiation	R-HSA-68952	6.379588e-01	0.195
Regulation of the apoptosome activity	R-HSA-9627069	6.379588e-01	0.195
Regulation of CDH11 function	R-HSA-9762292	6.379588e-01	0.195
Formation of apoptosome	R-HSA-111458	6.379588e-01	0.195
EGFR Transactivation by Gastrin	R-HSA-2179392	6.379588e-01	0.195
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	6.379588e-01	0.195
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	6.379588e-01	0.195
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	6.379588e-01	0.195
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	6.379588e-01	0.195
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	6.379588e-01	0.195
Formation of intermediate mesoderm	R-HSA-9761174	6.379588e-01	0.195
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	6.379588e-01	0.195
2-LTR circle formation	R-HSA-164843	6.379588e-01	0.195
Pexophagy	R-HSA-9664873	6.379588e-01	0.195
Receptor Mediated Mitophagy	R-HSA-8934903	6.379588e-01	0.195
Co-inhibition by PD-1	R-HSA-389948	6.396297e-01	0.194
Pre-NOTCH Expression and Processing	R-HSA-1912422	6.409494e-01	0.193
FGFR2 alternative splicing	R-HSA-6803529	6.426060e-01	0.192
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.426060e-01	0.192
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	6.426060e-01	0.192
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	6.426060e-01	0.192
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.426060e-01	0.192
LDL clearance	R-HSA-8964038	6.426060e-01	0.192
Signaling by PTK6	R-HSA-8848021	6.502331e-01	0.187
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	6.502331e-01	0.187
Calmodulin induced events	R-HSA-111933	6.526900e-01	0.185
CaM pathway	R-HSA-111997	6.526900e-01	0.185
Potential therapeutics for SARS	R-HSA-9679191	6.604580e-01	0.180
Formation of the ureteric bud	R-HSA-9830674	6.613902e-01	0.180
Carnitine shuttle	R-HSA-200425	6.613902e-01	0.180
Syndecan interactions	R-HSA-3000170	6.613902e-01	0.180
Growth hormone receptor signaling	R-HSA-982772	6.613902e-01	0.180
Insulin receptor signalling cascade	R-HSA-74751	6.621409e-01	0.179
IGF1R signaling cascade	R-HSA-2428924	6.621409e-01	0.179
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.621409e-01	0.179
PI3K Cascade	R-HSA-109704	6.633820e-01	0.178
Cilium Assembly	R-HSA-5617833	6.636485e-01	0.178
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	6.651876e-01	0.177
Signaling by APC mutants	R-HSA-4839744	6.651876e-01	0.177
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	6.651876e-01	0.177
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	6.651876e-01	0.177
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	6.651876e-01	0.177
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	6.651876e-01	0.177
LGI-ADAM interactions	R-HSA-5682910	6.651876e-01	0.177
vRNP Assembly	R-HSA-192905	6.651876e-01	0.177
RHOBTB3 ATPase cycle	R-HSA-9706019	6.651876e-01	0.177
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	6.651876e-01	0.177
SIRT1 negatively regulates rRNA expression	R-HSA-427359	6.677871e-01	0.175
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.737826e-01	0.171
IRE1alpha activates chaperones	R-HSA-381070	6.737946e-01	0.171
Response of endothelial cells to shear stress	R-HSA-9860931	6.750666e-01	0.171
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	6.793722e-01	0.168
Influenza Infection	R-HSA-168255	6.814500e-01	0.167
DNA Replication	R-HSA-69306	6.834249e-01	0.165
PKR-mediated signaling	R-HSA-9833482	6.836887e-01	0.165
RNA Polymerase I Promoter Escape	R-HSA-73772	6.888150e-01	0.162
Synthesis of diphthamide-EEF2	R-HSA-5358493	6.903701e-01	0.161
Proton-coupled monocarboxylate transport	R-HSA-433692	6.903701e-01	0.161
Signaling by GSK3beta mutants	R-HSA-5339716	6.903701e-01	0.161
Cytochrome c-mediated apoptotic response	R-HSA-111461	6.903701e-01	0.161
Integration of provirus	R-HSA-162592	6.903701e-01	0.161
Plasmalogen biosynthesis	R-HSA-75896	6.903701e-01	0.161
Signaling by AMER1 mutants	R-HSA-4839748	6.903701e-01	0.161
Signaling by AXIN mutants	R-HSA-4839735	6.903701e-01	0.161
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	6.903701e-01	0.161
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	6.903701e-01	0.161
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	6.903701e-01	0.161
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	6.903701e-01	0.161
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.950429e-01	0.158
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.962571e-01	0.157
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.965259e-01	0.157
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	6.965664e-01	0.157
HDMs demethylate histones	R-HSA-3214842	6.965664e-01	0.157
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	6.965664e-01	0.157
Sema4D in semaphorin signaling	R-HSA-400685	6.965664e-01	0.157
Interleukin-7 signaling	R-HSA-1266695	6.965664e-01	0.157
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	7.010096e-01	0.154
Golgi Associated Vesicle Biogenesis	R-HSA-432722	7.010096e-01	0.154
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	7.070866e-01	0.151
Formation of Incision Complex in GG-NER	R-HSA-5696395	7.101718e-01	0.149
Nuclear signaling by ERBB4	R-HSA-1251985	7.101718e-01	0.149
Glycogen metabolism	R-HSA-8982491	7.101718e-01	0.149
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.129895e-01	0.147
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.129895e-01	0.147
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.129895e-01	0.147
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	7.136598e-01	0.147
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	7.136598e-01	0.147
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	7.136598e-01	0.147
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	7.136598e-01	0.147
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	7.136598e-01	0.147
Interleukin-15 signaling	R-HSA-8983432	7.136598e-01	0.147
GRB2 events in EGFR signaling	R-HSA-179812	7.136598e-01	0.147
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	7.136598e-01	0.147
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.136598e-01	0.147
Regulation of IFNG signaling	R-HSA-877312	7.136598e-01	0.147
p75NTR recruits signalling complexes	R-HSA-209543	7.136598e-01	0.147
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.136598e-01	0.147
Diseases associated with surfactant metabolism	R-HSA-5687613	7.136598e-01	0.147
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.136598e-01	0.147
MET activates RAS signaling	R-HSA-8851805	7.136598e-01	0.147
MAPK family signaling cascades	R-HSA-5683057	7.188904e-01	0.143
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	7.190739e-01	0.143
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	7.190739e-01	0.143
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	7.233403e-01	0.141
Maturation of spike protein	R-HSA-9694548	7.233403e-01	0.141
G alpha (z) signalling events	R-HSA-418597	7.243543e-01	0.140
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	7.279258e-01	0.138
Cyclin E associated events during G1/S transition	R-HSA-69202	7.279258e-01	0.138
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	7.286603e-01	0.137
Interaction between L1 and Ankyrins	R-HSA-445095	7.286603e-01	0.137
RNA Polymerase I Promoter Opening	R-HSA-73728	7.286603e-01	0.137
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.286603e-01	0.137
Formation of axial mesoderm	R-HSA-9796292	7.351991e-01	0.134
Processing of SMDT1	R-HSA-8949664	7.351991e-01	0.134
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	7.351991e-01	0.134
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	7.351991e-01	0.134
CD28 dependent Vav1 pathway	R-HSA-389359	7.351991e-01	0.134
Maturation of nucleoprotein	R-HSA-9683610	7.351991e-01	0.134
Interleukin-6 signaling	R-HSA-1059683	7.351991e-01	0.134
Replication of the SARS-CoV-1 genome	R-HSA-9682706	7.351991e-01	0.134
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.360369e-01	0.133
SLC-mediated transport of neurotransmitters	R-HSA-442660	7.360369e-01	0.133
Hedgehog 'on' state	R-HSA-5632684	7.379358e-01	0.132
Regulation of T cell activation by CD28 family	R-HSA-388841	7.406764e-01	0.130
Negative regulation of FGFR3 signaling	R-HSA-5654732	7.435989e-01	0.129
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	7.435989e-01	0.129
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	7.435989e-01	0.129
Inflammasomes	R-HSA-622312	7.435989e-01	0.129
Pyroptosis	R-HSA-5620971	7.435989e-01	0.129
IRS-mediated signalling	R-HSA-112399	7.463157e-01	0.127
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	7.476737e-01	0.126
Cytosolic tRNA aminoacylation	R-HSA-379716	7.482680e-01	0.126
Ca-dependent events	R-HSA-111996	7.482680e-01	0.126
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.551193e-01	0.122
CRMPs in Sema3A signaling	R-HSA-399956	7.551193e-01	0.122
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	7.551193e-01	0.122
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	7.551193e-01	0.122
NRIF signals cell death from the nucleus	R-HSA-205043	7.551193e-01	0.122
Signaling by FGFR4 in disease	R-HSA-5655291	7.551193e-01	0.122
Physiological factors	R-HSA-5578768	7.551193e-01	0.122
HDL assembly	R-HSA-8963896	7.551193e-01	0.122
Zinc transporters	R-HSA-435354	7.551193e-01	0.122
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	7.551193e-01	0.122
Dual incision in TC-NER	R-HSA-6782135	7.567837e-01	0.121
Impaired BRCA2 binding to RAD51	R-HSA-9709570	7.578268e-01	0.120
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.578268e-01	0.120
Termination of translesion DNA synthesis	R-HSA-5656169	7.578268e-01	0.120
Glucagon-type ligand receptors	R-HSA-420092	7.578268e-01	0.120
Post NMDA receptor activation events	R-HSA-438064	7.593503e-01	0.120
Chaperonin-mediated protein folding	R-HSA-390466	7.593503e-01	0.120
Adherens junctions interactions	R-HSA-418990	7.594923e-01	0.119
Signaling by FGFR4	R-HSA-5654743	7.600410e-01	0.119
Response of Mtb to phagocytosis	R-HSA-9637690	7.600410e-01	0.119
Hedgehog 'off' state	R-HSA-5610787	7.625805e-01	0.118
Interferon Signaling	R-HSA-913531	7.639290e-01	0.117
Signaling by NOTCH4	R-HSA-9013694	7.663390e-01	0.116
KEAP1-NFE2L2 pathway	R-HSA-9755511	7.666935e-01	0.115
Extension of Telomeres	R-HSA-180786	7.669146e-01	0.115
Interleukin-1 signaling	R-HSA-9020702	7.704052e-01	0.113
Downregulation of ERBB2 signaling	R-HSA-8863795	7.713664e-01	0.113
Interleukin-1 family signaling	R-HSA-446652	7.730422e-01	0.112
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	7.735421e-01	0.112
SHC1 events in EGFR signaling	R-HSA-180336	7.735421e-01	0.112
Beta-catenin phosphorylation cascade	R-HSA-196299	7.735421e-01	0.112
RNA Polymerase III Chain Elongation	R-HSA-73780	7.735421e-01	0.112
ERBB2 Regulates Cell Motility	R-HSA-6785631	7.735421e-01	0.112
Telomere C-strand synthesis initiation	R-HSA-174430	7.735421e-01	0.112
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	7.735421e-01	0.112
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	7.735421e-01	0.112
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	7.735421e-01	0.112
IRF3-mediated induction of type I IFN	R-HSA-3270619	7.735421e-01	0.112
Protein methylation	R-HSA-8876725	7.735421e-01	0.112
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	7.735421e-01	0.112
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.752704e-01	0.111
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.752704e-01	0.111
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	7.780393e-01	0.109
Signaling by FGFR3	R-HSA-5654741	7.822463e-01	0.107
Trafficking of AMPA receptors	R-HSA-399719	7.842406e-01	0.106
Downstream signal transduction	R-HSA-186763	7.842406e-01	0.106
PLC beta mediated events	R-HSA-112043	7.861822e-01	0.104
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	7.905799e-01	0.102
Defective GALNT3 causes HFTC	R-HSA-5083625	7.905799e-01	0.102
Defective GALNT12 causes CRCS1	R-HSA-5083636	7.905799e-01	0.102
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	7.905799e-01	0.102
Killing mechanisms	R-HSA-9664420	7.905799e-01	0.102
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	7.905799e-01	0.102
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.905799e-01	0.102
Class I peroxisomal membrane protein import	R-HSA-9603798	7.905799e-01	0.102
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	7.905799e-01	0.102
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	7.905799e-01	0.102
Regulation of NF-kappa B signaling	R-HSA-9758274	7.905799e-01	0.102
Activation of SMO	R-HSA-5635838	7.905799e-01	0.102
Condensation of Prophase Chromosomes	R-HSA-2299718	7.926970e-01	0.101
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.926970e-01	0.101
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.926970e-01	0.101
Diseases of DNA repair	R-HSA-9675135	7.926970e-01	0.101
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	7.927403e-01	0.101
Cap-dependent Translation Initiation	R-HSA-72737	7.945912e-01	0.100
Eukaryotic Translation Initiation	R-HSA-72613	7.945912e-01	0.100
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.953286e-01	0.099
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.027263e-01	0.095
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	8.027263e-01	0.095
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	8.027263e-01	0.095
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	8.027263e-01	0.095
HCMV Late Events	R-HSA-9610379	8.029581e-01	0.095
G beta:gamma signalling through CDC42	R-HSA-8964616	8.063368e-01	0.093
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.063368e-01	0.093
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.063368e-01	0.093
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.063368e-01	0.093
Synthesis of PG	R-HSA-1483148	8.063368e-01	0.093
Coenzyme A biosynthesis	R-HSA-196783	8.063368e-01	0.093
tRNA modification in the mitochondrion	R-HSA-6787450	8.063368e-01	0.093
Protein folding	R-HSA-391251	8.067307e-01	0.093
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	8.080871e-01	0.093
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.080871e-01	0.093
G-protein beta:gamma signalling	R-HSA-397795	8.080871e-01	0.093
Negative regulation of FGFR1 signaling	R-HSA-5654726	8.080871e-01	0.093
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.080871e-01	0.093
Cardiogenesis	R-HSA-9733709	8.080871e-01	0.093
Co-stimulation by CD28	R-HSA-389356	8.123448e-01	0.090
Gluconeogenesis	R-HSA-70263	8.123448e-01	0.090
Signaling by FGFR2	R-HSA-5654738	8.160292e-01	0.088
Ub-specific processing proteases	R-HSA-5689880	8.168000e-01	0.088
Glucagon signaling in metabolic regulation	R-HSA-163359	8.191068e-01	0.087
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	8.191068e-01	0.087
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.191068e-01	0.087
Cellular response to hypoxia	R-HSA-1234174	8.208854e-01	0.086
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.209090e-01	0.086
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	8.209090e-01	0.086
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	8.209090e-01	0.086
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.209090e-01	0.086
Elevation of cytosolic Ca2+ levels	R-HSA-139853	8.209090e-01	0.086
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.209090e-01	0.086
Choline catabolism	R-HSA-6798163	8.209090e-01	0.086
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.209090e-01	0.086
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.209090e-01	0.086
Gap junction trafficking and regulation	R-HSA-157858	8.215631e-01	0.085
Amyloid fiber formation	R-HSA-977225	8.234260e-01	0.084
Dual Incision in GG-NER	R-HSA-5696400	8.295557e-01	0.081
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.295557e-01	0.081
Negative regulation of FGFR2 signaling	R-HSA-5654727	8.295557e-01	0.081
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	8.295557e-01	0.081
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.295557e-01	0.081
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	8.295557e-01	0.081
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	8.295557e-01	0.081
Regulation of RAS by GAPs	R-HSA-5658442	8.303923e-01	0.081
Signaling by FGFR2 in disease	R-HSA-5655253	8.303923e-01	0.081
G beta:gamma signalling through PLC beta	R-HSA-418217	8.343855e-01	0.079
Transport of connexons to the plasma membrane	R-HSA-190872	8.343855e-01	0.079
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.343855e-01	0.079
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	8.343855e-01	0.079
Presynaptic function of Kainate receptors	R-HSA-500657	8.343855e-01	0.079
Apoptotic factor-mediated response	R-HSA-111471	8.343855e-01	0.079
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	8.343855e-01	0.079
Synaptic adhesion-like molecules	R-HSA-8849932	8.343855e-01	0.079
Tie2 Signaling	R-HSA-210993	8.343855e-01	0.079
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	8.343855e-01	0.079
G-protein mediated events	R-HSA-112040	8.364165e-01	0.078
Kidney development	R-HSA-9830369	8.364165e-01	0.078
Cytoprotection by HMOX1	R-HSA-9707564	8.374973e-01	0.077
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	8.376872e-01	0.077
TCR signaling	R-HSA-202403	8.384117e-01	0.077
Activation of NF-kappaB in B cells	R-HSA-1169091	8.388438e-01	0.076
Regulation of Apoptosis	R-HSA-169911	8.394573e-01	0.076
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	8.394573e-01	0.076
Defects in vitamin and cofactor metabolism	R-HSA-3296482	8.394573e-01	0.076
PI-3K cascade:FGFR3	R-HSA-5654710	8.468487e-01	0.072
Pyrimidine biosynthesis	R-HSA-500753	8.468487e-01	0.072
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	8.468487e-01	0.072
IKK complex recruitment mediated by RIP1	R-HSA-937041	8.468487e-01	0.072
Translesion Synthesis by POLH	R-HSA-110320	8.468487e-01	0.072
Other interleukin signaling	R-HSA-449836	8.468487e-01	0.072
STING mediated induction of host immune responses	R-HSA-1834941	8.468487e-01	0.072
Maturation of nucleoprotein	R-HSA-9694631	8.468487e-01	0.072
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.468487e-01	0.072
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	8.469288e-01	0.072
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	8.469288e-01	0.072
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.469288e-01	0.072
Cell-cell junction organization	R-HSA-421270	8.479499e-01	0.072
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.482344e-01	0.071
Glycosphingolipid transport	R-HSA-9845576	8.488348e-01	0.071
FGFR2 mutant receptor activation	R-HSA-1839126	8.488348e-01	0.071
SLC transporter disorders	R-HSA-5619102	8.539000e-01	0.069
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.546590e-01	0.068
Fatty acyl-CoA biosynthesis	R-HSA-75105	8.575872e-01	0.067
Regulation of PD-L1(CD274) translation	R-HSA-9909620	8.583746e-01	0.066
PI-3K cascade:FGFR4	R-HSA-5654720	8.583746e-01	0.066
Wax and plasmalogen biosynthesis	R-HSA-8848584	8.583746e-01	0.066
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.583746e-01	0.066
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.583746e-01	0.066
Signal transduction by L1	R-HSA-445144	8.583746e-01	0.066
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.620457e-01	0.064
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.620457e-01	0.064
Signaling by WNT	R-HSA-195721	8.622786e-01	0.064
Platelet degranulation	R-HSA-114608	8.638637e-01	0.064
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	8.641055e-01	0.063
Regulation of mitotic cell cycle	R-HSA-453276	8.641055e-01	0.063
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.643632e-01	0.063
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.661079e-01	0.062
PPARA activates gene expression	R-HSA-1989781	8.669473e-01	0.062
Viral Infection Pathways	R-HSA-9824446	8.687203e-01	0.061
MyD88 deficiency (TLR2/4)	R-HSA-5602498	8.690338e-01	0.061
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.690338e-01	0.061
TNFR1-induced proapoptotic signaling	R-HSA-5357786	8.690338e-01	0.061
Early Phase of HIV Life Cycle	R-HSA-162594	8.690338e-01	0.061
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.691006e-01	0.061
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	8.691006e-01	0.061
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.703663e-01	0.060
Stabilization of p53	R-HSA-69541	8.740478e-01	0.058
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.740478e-01	0.058
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.754584e-01	0.058
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.758349e-01	0.058
Signaling by FGFR1	R-HSA-5654736	8.758349e-01	0.058
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	8.788913e-01	0.056
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	8.788913e-01	0.056
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	8.788913e-01	0.056
Mitochondrial calcium ion transport	R-HSA-8949215	8.788913e-01	0.056
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	8.788913e-01	0.056
Molybdenum cofactor biosynthesis	R-HSA-947581	8.788913e-01	0.056
Serine metabolism	R-HSA-977347	8.788913e-01	0.056
Signaling by NTRK3 (TRKC)	R-HSA-9034015	8.788913e-01	0.056
RAF/MAP kinase cascade	R-HSA-5673001	8.797261e-01	0.056
Diseases of Immune System	R-HSA-5260271	8.815516e-01	0.055
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.815516e-01	0.055
Interferon gamma signaling	R-HSA-877300	8.835235e-01	0.054
Base Excision Repair	R-HSA-73884	8.848476e-01	0.053
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	8.880074e-01	0.052
PI-3K cascade:FGFR1	R-HSA-5654689	8.880074e-01	0.052
Ethanol oxidation	R-HSA-71384	8.880074e-01	0.052
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	8.880074e-01	0.052
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	8.880074e-01	0.052
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.886400e-01	0.051
RSV-host interactions	R-HSA-9833110	8.888982e-01	0.051
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.942277e-01	0.049
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	8.946459e-01	0.048
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.953331e-01	0.048
Intra-Golgi traffic	R-HSA-6811438	8.953331e-01	0.048
Degradation of GLI1 by the proteasome	R-HSA-5610780	8.953331e-01	0.048
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.953331e-01	0.048
Regulation of PTEN mRNA translation	R-HSA-8943723	8.964378e-01	0.047
Termination of O-glycan biosynthesis	R-HSA-977068	8.964378e-01	0.047
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	8.964378e-01	0.047
Free fatty acids regulate insulin secretion	R-HSA-400451	8.964378e-01	0.047
Organic anion transport by SLCO transporters	R-HSA-879518	8.964378e-01	0.047
Translation of Structural Proteins	R-HSA-9694635	8.980653e-01	0.047
Signaling by Insulin receptor	R-HSA-74752	8.992791e-01	0.046
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.992791e-01	0.046
tRNA Aminoacylation	R-HSA-379724	8.997921e-01	0.046
MAPK1/MAPK3 signaling	R-HSA-5684996	8.998928e-01	0.046
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.016502e-01	0.045
Cleavage of the damaged pyrimidine	R-HSA-110329	9.016502e-01	0.045
Depyrimidination	R-HSA-73928	9.016502e-01	0.045
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.016852e-01	0.045
Integrin cell surface interactions	R-HSA-216083	9.029347e-01	0.044
Cellular response to chemical stress	R-HSA-9711123	9.037087e-01	0.044
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.042341e-01	0.044
Mitochondrial RNA degradation	R-HSA-9836573	9.042341e-01	0.044
Complex III assembly	R-HSA-9865881	9.042341e-01	0.044
Plasma lipoprotein assembly	R-HSA-8963898	9.042341e-01	0.044
Interleukin-6 family signaling	R-HSA-6783589	9.042341e-01	0.044
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.050912e-01	0.043
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.101354e-01	0.041
NCAM signaling for neurite out-growth	R-HSA-375165	9.101354e-01	0.041
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.101354e-01	0.041
Signaling by PDGF	R-HSA-186797	9.101354e-01	0.041
PI-3K cascade:FGFR2	R-HSA-5654695	9.114439e-01	0.040
Long-term potentiation	R-HSA-9620244	9.114439e-01	0.040
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.114439e-01	0.040
Tight junction interactions	R-HSA-420029	9.114439e-01	0.040
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.114439e-01	0.040
Hyaluronan degradation	R-HSA-2160916	9.114439e-01	0.040
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.114439e-01	0.040
Laminin interactions	R-HSA-3000157	9.114439e-01	0.040
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.114439e-01	0.040
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.120599e-01	0.040
Gap junction trafficking	R-HSA-190828	9.132301e-01	0.039
Surfactant metabolism	R-HSA-5683826	9.132301e-01	0.039
Amine ligand-binding receptors	R-HSA-375280	9.132301e-01	0.039
Muscle contraction	R-HSA-397014	9.143704e-01	0.039
G1/S DNA Damage Checkpoints	R-HSA-69615	9.149351e-01	0.039
Signaling by Hedgehog	R-HSA-5358351	9.161744e-01	0.038
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.181113e-01	0.037
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.181113e-01	0.037
Urea cycle	R-HSA-70635	9.181113e-01	0.037
Sphingolipid catabolism	R-HSA-9845614	9.181113e-01	0.037
Asymmetric localization of PCP proteins	R-HSA-4608870	9.185282e-01	0.037
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.185282e-01	0.037
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.185282e-01	0.037
Fanconi Anemia Pathway	R-HSA-6783310	9.185282e-01	0.037
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.235209e-01	0.035
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.235209e-01	0.035
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.242771e-01	0.034
Packaging Of Telomere Ends	R-HSA-171306	9.242771e-01	0.034
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.242771e-01	0.034
Cristae formation	R-HSA-8949613	9.242771e-01	0.034
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	9.242771e-01	0.034
Signaling by FGFR3 in disease	R-HSA-5655332	9.242771e-01	0.034
Insulin processing	R-HSA-264876	9.242771e-01	0.034
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.242771e-01	0.034
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.254462e-01	0.034
Transport to the Golgi and subsequent modification	R-HSA-948021	9.257111e-01	0.034
Signaling by FGFR	R-HSA-190236	9.269820e-01	0.033
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.279654e-01	0.032
Synthesis of PC	R-HSA-1483191	9.282241e-01	0.032
Telomere Extension By Telomerase	R-HSA-171319	9.299789e-01	0.032
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.299789e-01	0.032
Cellular response to starvation	R-HSA-9711097	9.309639e-01	0.031
Ion channel transport	R-HSA-983712	9.319725e-01	0.031
GPER1 signaling	R-HSA-9634597	9.326530e-01	0.030
Metal ion SLC transporters	R-HSA-425410	9.326530e-01	0.030
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.337665e-01	0.030
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.352518e-01	0.029
Downstream signaling of activated FGFR3	R-HSA-5654708	9.352518e-01	0.029
Platelet calcium homeostasis	R-HSA-418360	9.352518e-01	0.029
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	9.368223e-01	0.028
p53-Dependent G1 DNA Damage Response	R-HSA-69563	9.368223e-01	0.028
Reproduction	R-HSA-1474165	9.374301e-01	0.028
PI Metabolism	R-HSA-1483255	9.395698e-01	0.027
DAP12 signaling	R-HSA-2424491	9.401278e-01	0.027
Downstream signaling of activated FGFR4	R-HSA-5654716	9.401278e-01	0.027
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.401278e-01	0.027
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.401278e-01	0.027
Neurotransmitter clearance	R-HSA-112311	9.401278e-01	0.027
Degradation of beta-catenin by the destruction complex	R-HSA-195253	9.424917e-01	0.026
Peptide chain elongation	R-HSA-156902	9.443236e-01	0.025
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.444372e-01	0.025
Meiotic recombination	R-HSA-912446	9.444372e-01	0.025
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.446370e-01	0.025
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.446370e-01	0.025
Cargo concentration in the ER	R-HSA-5694530	9.446370e-01	0.025
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.446370e-01	0.025
Molecules associated with elastic fibres	R-HSA-2129379	9.446370e-01	0.025
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.486892e-01	0.023
Signaling by WNT in cancer	R-HSA-4791275	9.488068e-01	0.023
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.488068e-01	0.023
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.488068e-01	0.023
Platelet activation, signaling and aggregation	R-HSA-76002	9.488655e-01	0.023
Amino acids regulate mTORC1	R-HSA-9639288	9.511732e-01	0.022
Nucleotide biosynthesis	R-HSA-8956320	9.511732e-01	0.022
Ca2+ pathway	R-HSA-4086398	9.515493e-01	0.022
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.523980e-01	0.021
Integrin signaling	R-HSA-354192	9.526627e-01	0.021
Neutrophil degranulation	R-HSA-6798695	9.541241e-01	0.020
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.542415e-01	0.020
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.548120e-01	0.020
Acyl chain remodelling of PC	R-HSA-1482788	9.562284e-01	0.019
Miscellaneous transport and binding events	R-HSA-5223345	9.562284e-01	0.019
Protein ubiquitination	R-HSA-8852135	9.568283e-01	0.019
Adaptive Immune System	R-HSA-1280218	9.570378e-01	0.019
Eukaryotic Translation Elongation	R-HSA-156842	9.571670e-01	0.019
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.571670e-01	0.019
Gap junction assembly	R-HSA-190861	9.595258e-01	0.018
eNOS activation	R-HSA-203615	9.595258e-01	0.018
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.595258e-01	0.018
Hyaluronan metabolism	R-HSA-2142845	9.595258e-01	0.018
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.595258e-01	0.018
NPAS4 regulates expression of target genes	R-HSA-9768919	9.595258e-01	0.018
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.598337e-01	0.018
C-type lectin receptors (CLRs)	R-HSA-5621481	9.602340e-01	0.018
Downstream signaling of activated FGFR2	R-HSA-5654696	9.625749e-01	0.017
Downstream signaling of activated FGFR1	R-HSA-5654687	9.625749e-01	0.017
Acyl chain remodelling of PE	R-HSA-1482839	9.625749e-01	0.017
PCP/CE pathway	R-HSA-4086400	9.637453e-01	0.016
SLC-mediated transport of organic anions	R-HSA-9955298	9.637453e-01	0.016
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.647398e-01	0.016
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.647398e-01	0.016
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.647671e-01	0.016
Lysosome Vesicle Biogenesis	R-HSA-432720	9.653945e-01	0.015
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.653945e-01	0.015
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.653945e-01	0.015
GPVI-mediated activation cascade	R-HSA-114604	9.653945e-01	0.015
Formation of a pool of free 40S subunits	R-HSA-72689	9.654076e-01	0.015
Peroxisomal protein import	R-HSA-9033241	9.670100e-01	0.015
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.672238e-01	0.014
Voltage gated Potassium channels	R-HSA-1296072	9.680018e-01	0.014
Degradation of DVL	R-HSA-4641258	9.680018e-01	0.014
Cleavage of the damaged purine	R-HSA-110331	9.680018e-01	0.014
NCAM1 interactions	R-HSA-419037	9.680018e-01	0.014
SLC-mediated transport of organic cations	R-HSA-549127	9.680018e-01	0.014
Collagen chain trimerization	R-HSA-8948216	9.680018e-01	0.014
Metabolism of folate and pterines	R-HSA-196757	9.680018e-01	0.014
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.691151e-01	0.014
tRNA processing in the mitochondrion	R-HSA-6785470	9.704129e-01	0.013
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.704129e-01	0.013
Depurination	R-HSA-73927	9.704129e-01	0.013
Elastic fibre formation	R-HSA-1566948	9.704129e-01	0.013
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.704129e-01	0.013
Post-translational protein phosphorylation	R-HSA-8957275	9.705925e-01	0.013
Regulation of insulin secretion	R-HSA-422356	9.705925e-01	0.013
Aquaporin-mediated transport	R-HSA-445717	9.710904e-01	0.013
Formation of paraxial mesoderm	R-HSA-9793380	9.710904e-01	0.013
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.746818e-01	0.011
Complex I biogenesis	R-HSA-6799198	9.746818e-01	0.011
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.747039e-01	0.011
rRNA processing in the mitochondrion	R-HSA-8868766	9.747039e-01	0.011
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.747039e-01	0.011
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.747039e-01	0.011
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.747039e-01	0.011
Ion transport by P-type ATPases	R-HSA-936837	9.763118e-01	0.010
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.766103e-01	0.010
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.766103e-01	0.010
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.783731e-01	0.009
Scavenging by Class A Receptors	R-HSA-3000480	9.783731e-01	0.009
Translation of Structural Proteins	R-HSA-9683701	9.783731e-01	0.009
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.785580e-01	0.009
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.787510e-01	0.009
Opioid Signalling	R-HSA-111885	9.788560e-01	0.009
Beta-catenin independent WNT signaling	R-HSA-3858494	9.794789e-01	0.009
Neddylation	R-HSA-8951664	9.806510e-01	0.008
Ribosome-associated quality control	R-HSA-9948299	9.814111e-01	0.008
Defensins	R-HSA-1461973	9.815104e-01	0.008
Formation of the cornified envelope	R-HSA-6809371	9.828389e-01	0.008
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.829042e-01	0.007
DAP12 interactions	R-HSA-2172127	9.829042e-01	0.007
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.829042e-01	0.007
EPHB-mediated forward signaling	R-HSA-3928662	9.829042e-01	0.007
Methylation	R-HSA-156581	9.829042e-01	0.007
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.831725e-01	0.007
Leishmania phagocytosis	R-HSA-9664417	9.831725e-01	0.007
Parasite infection	R-HSA-9664407	9.831725e-01	0.007
Platelet Aggregation (Plug Formation)	R-HSA-76009	9.841930e-01	0.007
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.841930e-01	0.007
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.841930e-01	0.007
Immune System	R-HSA-168256	9.849109e-01	0.007
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.851902e-01	0.006
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.852338e-01	0.006
Regulation of pyruvate metabolism	R-HSA-9861718	9.853846e-01	0.006
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.853846e-01	0.006
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.861331e-01	0.006
Diseases of carbohydrate metabolism	R-HSA-5663084	9.870649e-01	0.006
FCERI mediated MAPK activation	R-HSA-2871796	9.872601e-01	0.006
Collagen formation	R-HSA-1474290	9.877166e-01	0.005
Degradation of CDH1	R-HSA-9766229	9.884476e-01	0.005
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.884476e-01	0.005
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.884511e-01	0.005
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.891432e-01	0.005
Eukaryotic Translation Termination	R-HSA-72764	9.891432e-01	0.005
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.892707e-01	0.005
Complex IV assembly	R-HSA-9864848	9.901242e-01	0.004
The phototransduction cascade	R-HSA-2514856	9.901242e-01	0.004
Cholesterol biosynthesis	R-HSA-191273	9.907970e-01	0.004
Interleukin-10 signaling	R-HSA-6783783	9.907970e-01	0.004
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.908690e-01	0.004
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.912970e-01	0.004
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.914318e-01	0.004
Regulation of PTEN stability and activity	R-HSA-8948751	9.915577e-01	0.004
Protein localization	R-HSA-9609507	9.917636e-01	0.004
Selenocysteine synthesis	R-HSA-2408557	9.925287e-01	0.003
Ion homeostasis	R-HSA-5578775	9.933276e-01	0.003
Viral mRNA Translation	R-HSA-192823	9.934108e-01	0.003
G alpha (q) signalling events	R-HSA-416476	9.934599e-01	0.003
Disorders of transmembrane transporters	R-HSA-5619115	9.935714e-01	0.003
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.936628e-01	0.003
Regulation of CDH1 Function	R-HSA-9764561	9.938310e-01	0.003
Dectin-2 family	R-HSA-5621480	9.938310e-01	0.003
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.946910e-01	0.002
Amino acid transport across the plasma membrane	R-HSA-352230	9.947267e-01	0.002
Platelet homeostasis	R-HSA-418346	9.948824e-01	0.002
Neuronal System	R-HSA-112316	9.948978e-01	0.002
Pyruvate metabolism	R-HSA-70268	9.953777e-01	0.002
Collagen degradation	R-HSA-1442490	9.954925e-01	0.002
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.958076e-01	0.002
Mitochondrial protein import	R-HSA-1268020	9.958326e-01	0.002
ER-Phagosome pathway	R-HSA-1236974	9.959769e-01	0.002
Neurotransmitter release cycle	R-HSA-112310	9.962472e-01	0.002
Downstream TCR signaling	R-HSA-202424	9.962472e-01	0.002
Class B/2 (Secretin family receptors)	R-HSA-373080	9.962472e-01	0.002
Degradation of the extracellular matrix	R-HSA-1474228	9.968872e-01	0.001
Nicotinate metabolism	R-HSA-196807	9.971851e-01	0.001
SLC-mediated transport of amino acids	R-HSA-9958863	9.971851e-01	0.001
Hemostasis	R-HSA-109582	9.972368e-01	0.001
O-linked glycosylation of mucins	R-HSA-913709	9.973976e-01	0.001
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.973976e-01	0.001
rRNA processing	R-HSA-72312	9.976039e-01	0.001
COPII-mediated vesicle transport	R-HSA-204005	9.977757e-01	0.001
Metabolism of steroids	R-HSA-8957322	9.977913e-01	0.001
Potassium Channels	R-HSA-1296071	9.978551e-01	0.001
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.979437e-01	0.001
ECM proteoglycans	R-HSA-3000178	9.979437e-01	0.001
Metabolism of cofactors	R-HSA-8978934	9.979437e-01	0.001
Purine catabolism	R-HSA-74259	9.980989e-01	0.001
Aspirin ADME	R-HSA-9749641	9.982425e-01	0.001
Synthesis of bile acids and bile salts	R-HSA-192105	9.982632e-01	0.001
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.982865e-01	0.001
Phospholipid metabolism	R-HSA-1483257	9.983552e-01	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	9.984499e-01	0.001
Citric acid cycle (TCA cycle)	R-HSA-71403	9.984979e-01	0.001
Iron uptake and transport	R-HSA-917937	9.984979e-01	0.001
Selenoamino acid metabolism	R-HSA-2408522	9.985285e-01	0.001
Parasitic Infection Pathways	R-HSA-9824443	9.986531e-01	0.001
Leishmania infection	R-HSA-9658195	9.986531e-01	0.001
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.990018e-01	0.000
Gastrulation	R-HSA-9758941	9.990285e-01	0.000
Post-translational protein modification	R-HSA-597592	9.991325e-01	0.000
Antigen processing-Cross presentation	R-HSA-1236975	9.991443e-01	0.000
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.991943e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.992579e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.993089e-01	0.000
Translation	R-HSA-72766	9.995314e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.995499e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.995499e-01	0.000
Transmission across Chemical Synapses	R-HSA-112315	9.995649e-01	0.000
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.996880e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.997116e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.997722e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.997722e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.998053e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.998097e-01	0.000
ABC-family proteins mediated transport	R-HSA-382556	9.998337e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.998686e-01	0.000
Cardiac conduction	R-HSA-5576891	9.998771e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.998897e-01	0.000
Keratinization	R-HSA-6805567	9.998976e-01	0.000
Infectious disease	R-HSA-5663205	9.999134e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999243e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999344e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999362e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999578e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.999588e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999655e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999740e-01	0.000
Innate Immune System	R-HSA-168249	9.999792e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999817e-01	0.000
Disease	R-HSA-1643685	9.999839e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999876e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999930e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999944e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999948e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999948e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999955e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999955e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999957e-01	0.000
Complement cascade	R-HSA-166658	9.999972e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999973e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999976e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999983e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999983e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999992e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999999e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999999e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999999e-01	0.000
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000