MARK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

Log-Odds: S Sites / S Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	S939	Sugiyama	POTEF A26C1B	VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
O00231	S298	Sugiyama	PSMD11	RYAGRQTEALKCVAQASKNRsLADFEKALTDYRAELRDDPI
O00468	S641	Sugiyama	AGRN AGRIN	PRCEHPPPGPVCGSDGVTyGsACELREAACLQQtQIEEARA
O14639	S452	Sugiyama	ABLIM1 ABLIM KIAA0059 LIMAB1	PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14910	S135	Sugiyama	LIN7A MALS1 VELI1	DEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLKRGDQL
O14974	S445	Sugiyama	PPP1R12A MBS MYPT1	EEERKDEsPATWRLGLRKtGsyGALAEItASKEGQKEKDTA
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14980	S1055	Sugiyama	XPO1 CRM1	LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15355	S349	Sugiyama	PPM1G PPM1C	tTAVVALIRGKQLIVANAGDsRCVVsEAGKALDMsyDHKPE
O15460	S531	Sugiyama	P4HA2 UNQ290/PRO330	KWVSNKWFHERGQEFLRPCGstEVD________________
O43290	S378	Sugiyama	SART1	DGLRERELEEIRAKLRLQAQsLSTVGPRLASEYLtPEEMVT
O43707	S763	Sugiyama	ACTN4	IARTINEVENQILtRDAKGIsQEQMQEFRASFNHFDKDHGG
O43765	S197	Sugiyama	SGTA SGT SGT1	EAVAYYKKALELDPDNEtyKsNLKIAELKLREAPSPTGGVG
O43815	S227	Sugiyama	STRN	NGTEAEVKETAMIAKSELtDsAsVLDNFKFLEsAAADFsDE
O43823	S323	Sugiyama	AKAP8 AKAP95	RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852	S69	Sugiyama	CALU	HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60333	S1057	Sugiyama	KIF1B KIAA0591 KIAA1448	DNEYFNQSDFSSVAMTRsGLsLEELRIVEGQGQSSEVItPP
O60716	S230	Sugiyama	CTNND1 KIAA0384	PDGysRHyEDGyPGGsDNyGsLsRVtRIEERyRPsMEGyRA
O60716	S252	Sugiyama	CTNND1 KIAA0384	sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60749	S119	Sugiyama	SNX2 TRG9	AVtPVtPttLIAPRIESKsMsAPVIFDRsREEIEEEANGDI
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75122	S313	Sugiyama	CLASP2 KIAA0627	YNSLEPSYQKSLQTYLKssGsVAsLPQsDRsssssQEsLNR
O75122	S327	Sugiyama	CLASP2 KIAA0627	YLKssGsVAsLPQsDRsssssQEsLNRPFSSKWSTANPSTV
O75140	S496	Sugiyama	DEPDC5 KIAA0645	QCLTTCRSVRERESHSRKsAssCDVsssPsLPSRTLPTEEV
O75179	S243	Sugiyama	ANKRD17 GTAR KIAA0697	RAEStANAGQSDNRSLAEACsEGDVNAVRKLLIEGRSVNEH
O75347	S60	Sugiyama	TBCA	MRAEDGENyDIKKQAEILQEsRMMIPDCQRRLEAAyLDLQR
O75390	S453	Sugiyama	CS	LAQLIWSRALGFPLERPKSMsTEGLMKFVDSKSG_______
O94776	S54	Sugiyama	MTA2 MTA1L1 PID	ANGNVEAKVVCLFRRRDIsssLNSLADSNAREFEEESKQPG
O94874	S777	Sugiyama	UFL1 KIAA0776 MAXER NLBP RCAD	LDKEQEDVASTTRKELQELSssIKDLVLKSRKSsVTEE___
O94874	S778	Sugiyama	UFL1 KIAA0776 MAXER NLBP RCAD	DKEQEDVASTTRKELQELSssIKDLVLKSRKSsVTEE____
O95155	S105	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95155	S79	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	NMtPAtsPIGASGVAHRsQssEGVssLsssPsNsLEtQsQs
O95218	S181	Sugiyama	ZRANB2 ZIS ZNF265	DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95671	T234	Sugiyama	ASMTL	PPRPEDLRRsVKHDsIPAADtFEDLsDVEGGGsEPTQRDAG
O95757	S599	Sugiyama	HSPA4L APG1 HSPH3 OSP94	sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
O95816	S31	Sugiyama	BAG2	NEGRFCRsssMADRsSRLLEsLDQLELRVEALREAATAVEQ
O95819	S800	Sugiyama	MAP4K4 HGK KIAA0687 NIK	DVEQEGADESTSGPEDTRAAsSLNLSNGETESVKTMIVHDD
P00338	S105	Sugiyama	LDHA PIG19	VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338	S319	Sugiyama	LDHA PIG19	GISDLVKVTLtsEEEARLKKsADtLWGIQKELQF_______
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00491	S176	Sugiyama	PNP NP	GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00558	S174	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558	S175	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P00558	S399	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00568	S38	Sugiyama	AK1	GSGKGTQCEKIVQKyGytHLstGDLLRSEVSSGSARGKKLs
P02545	S295	Sugiyama	LMNA LMN1	RQsAERNsNLVGAAHEELQQsRIRIDsLsAQLsQLQKQLAA
P04040	S515	Sugiyama	CAT	ALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL________
P04040	S517	Sugiyama	CAT	LDKYNAEKPKNAIHtFVQsGsHLAAREKANL__________
P04040	T511	Sugiyama	CAT	SHIQALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL____
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083	S173	Sugiyama	ANXA1 ANX1 LPC1	NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04083	S189	Sugiyama	ANXA1 ANX1 LPC1	tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04083	S201	Sugiyama	ANXA1 ANX1 LPC1	LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S176	Sugiyama	HSPB1 HSP27 HSP28	sLsPEGtLTVEAPMPKLAtQsNEItIPVtFEsRAQLGGPEA
P04792	S187	Sugiyama	HSPB1 HSP27 HSP28	APMPKLAtQsNEItIPVtFEsRAQLGGPEAAKsDETAAK__
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792	T184	Sugiyama	HSPB1 HSP27 HSP28	TVEAPMPKLAtQsNEItIPVtFEsRAQLGGPEAAKsDETAA
P05023	S369	Sugiyama	ATP1A1	KRMARKNCLVKNLEAVETLGstsTICSDKTGTLTQNRMTVA
P05198	S219	Sugiyama	EIF2S1 EIF2A	CYGYEGIDAVKEALRAGLNCsTENMPIKINLIAPPRYVMTT
P05198	S52	PSP	EIF2S1 EIF2A	AYVSLLEYNNIEGMILLsELsRRRIRSINKLIRIGRNECVV
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05455	S94	Sugiyama	SSB	KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05783	S401	Sugiyama	KRT18 CYK18 PIG46	RRLLEDGEDFNLGDALDssNsMQtIQKtTTRRIVDGKVVsE
P05787	S280	Sugiyama	KRT8 CYK8	IAEVKAQyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDL
P05787	S477	Sugiyama	KRT8 CYK8	SSRAVVVKKIETRDGKLVsEssDVLPK______________
P06280	S176	Sugiyama	GLA	AQTFADWGVDLLKFDGCYCDsLENLADGYKHMSLALNRTGR
P06733	S27	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733	S349	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	AKAVNEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMV
P06733	S353	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMVsHRs
P07195	S106	Sugiyama	LDHB	VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	S320	Sugiyama	LDHB	GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195	S44	Sugiyama	LDHB	ITVVGVGQVGMACAISILGKsLADELALVDVLEDKLKGEMM
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205	S399	Sugiyama	PGK2 PGKB	CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07339	S42	Sugiyama	CTSD CPSD	VRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQAVPAV
P07384	S474	Sugiyama	CAPN1 CANPL1 PIG30	GQPAVHLKRDFFLANAsRARsEQFINLREVSTRFRLPPGEY
P07437	S115	Sugiyama	TUBB TUBB5 OK/SW-cl.56	sGAGNNWAKGHytEGAELVDsVLDVVRKEAESCDCLQGFQL
P07437	S40	Sugiyama	TUBB TUBB5 OK/SW-cl.56	FWEVISDEHGIDPTGtyHGDsDLQLDRIsVyyNEAtGGKyV
P07711	S329	Sugiyama	CTSL CTSL1	GGyVKMAKDRRNHCGIAsAAsyPtV________________
P07814	S335	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07814	S747	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	ETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVREL
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S164	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	VAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGT
P07900	S391	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900	S399	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	S53	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P08195	S286	Sugiyama	SLC3A2 MDU1	KNQKDDVAQtDLLQIDPNFGsKEDFDsLLQsAKKKSIRVIL
P08195	S402	Sugiyama	SLC3A2 MDU1	SSDLQQILSLLESNKDLLLtssyLsDsGstGEHtKSLVTQY
P08195	S518	Sugiyama	SLC3A2 MDU1	DIPGAVSANMTVKGQsEDPGsLLsLFRRLsDQRsKERSLLH
P08238	S159	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	VAEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGT
P08238	S383	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238	S391	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238	S460	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S48	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238	S490	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	sEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRKRGFEV
P08670	S438	Sugiyama	VIM	FssLNLREtNLDsLPLVDtHsKRTLLIKtVEtRDGQVINEt
P09211	S66	Sugiyama	GSTP1 FAEES3 GST3	ASCLyGQLPKFQDGDLtLyQsNtILRHLGRTLGLYGKDQQE
P09923	S189	Sugiyama	ALPI	RVQHAsPAGtyAHtVNRNWysDADMPASARQEGCQDIATQL
P09960	S240	Sugiyama	LTA4H LTA4	LVWSEKEQVEKSAyEFsETEsMLKIAEDLGGPYVWGQYDLL
P0CG41	S140	Sugiyama	CTAGE8	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P0CG47	S57	Sugiyama	UBB	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48	S57	Sugiyama	UBC	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P10398	S157	Sugiyama	ARAF ARAF1 PKS PKS2	SSKVPTVCVDMSTNRQQFyHsVQDLsGGsRQHEAPsNRPLN
P10636	S355	SIGNOR	MAPT MAPTL MTBT1 TAU	PEARGPsLGEDTKEADLPEPsEKQPAAAPRGKPVsRVPQLK
P10809	S410	Sugiyama	HSPD1 HSP60	LNERLAKLsDGVAVLKVGGtsDVEVNEKKDRVtDALNAtRA
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11279	S141	Sugiyama	LAMP1	NLSDTHLFPNASSKEIKtVEsITDIRADIDKKYRCVSGTQV
P11413	S117	Sugiyama	G6PD	KLEDFFARNsyVAGQyDDAAsyQRLNsHMNALHLGsQANRL
P11586	S318	Sugiyama	MTHFD1 MTHFC MTHFD	FKPGKWMIQYNNLNLKTPVPsDIDIsRSCKPKPIGKLAREI
P11586	S765	Sugiyama	MTHFD1 MTHFC MTHFD	ARMFGIPVVVAVNAFKTDTEsELDLIsRLSREHGAFDAVKC
P12004	S172	Sugiyama	PCNA	sHIGDAVVIsCAKDGVKFSAsGELGNGNIKLSQTSNVDKEE
P12268	S416	Sugiyama	IMPDH2 IMPD2	APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P12814	S744	Sugiyama	ACTN1	IARTINEVENQILtRDAKGIsQEQMNEFRAsFNHFDRDHsG
P13473	S155	Sugiyama	LAMP2	LTVDELLAIRIPLNDLFRCNsLSTLEKNDVVQHYWDVLVQA
P13489	S178	Sugiyama	RNH1 PRI RNH	SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP
P13637	S359	Sugiyama	ATP1A3	KRMARKNCLVKNLEAVETLGstsTICSDKTGTLTQNRMTVA
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639	S38	Sugiyama	EEF2 EF2	NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13667	S470	Sugiyama	PDIA4 ERP70 ERP72	FAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAMEP
P13797	S540	Sugiyama	PLS3	NDDIIVNWVNRTLSEAGKSTsIQSFKDKTISSSLAVVDLID
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618	S100	Sugiyama	PKM OIP3 PK2 PK3 PKM2	tHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGPEIR
P14618	S202	Sugiyama	PKM OIP3 PK2 PK3 PKM2	SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618	S205	Sugiyama	PKM OIP3 PK2 PK3 PKM2	VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14625	S109	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625	S172	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI
P14625	S447	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	PKyLNFVKGVVDsDDLPLNVsREtLQQHKLLKVIRKKLVRK
P14625	S551	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKEKQDKIyFMAGsSRKEAEssPFVERLLKKGyEVIyLTEP
P14625	T171	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P15311	S144	Sugiyama	EZR VIL2	LLGSYAVQAKFGDYNKEVHKsGyLSsERLIPQRVMDQHKLT
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17987	S374	Sugiyama	TCP1 CCT1 CCTA	ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P17987	S544	Sugiyama	TCP1 CCT1 CCTA	ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P18615	S115	Sugiyama	NELFE RD RDBP	KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18615	S139	Sugiyama	NELFE RD RDBP	DLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEGPGAG
P18669	S14	Sugiyama	PGAM1 PGAMA CDABP0006	_______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P18669	S152	Sugiyama	PGAM1 PGAMA CDABP0006	FysNIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIV
P18754	S85	Sugiyama	RCC1 CHC1	IPEDVVQAEAGGMHTVCLSKsGQVysFGCNDEGALGRDtsV
P18850	S98	Sugiyama	ATF6	NQICTVKDIKAEPQPLsPAssSYsVssPRSVDSYSSTQHVP
P19338	S328	Sugiyama	NCL	NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338	S356	Sugiyama	NCL	LAVVDVRIGMTRKFGyVDFEsAEDLEKALELtGLKVFGNEI
P19338	S458	Sugiyama	NCL	TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338	Y463	Sugiyama	NCL	EKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWsG
P20674	S104	Sugiyama	COX5A	PEPKIIDAALRACRRLNDFAstVRILEVVKDKAGPHKEIYP
P21108	S11	Sugiyama	PRPS1L1 PRPS3 PRPSL	__________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P21333	S2152	Sugiyama	FLNA FLN FLN1	VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P21333	S2158	Sugiyama	FLNA FLN FLN1	GRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQDMtAQV
P22059	S379	Sugiyama	OSBP OSBP1	FFDAPEIITMPENLGHKRtGsNIsGAssDIsLDEQyKHQLE
P22059	S386	Sugiyama	OSBP OSBP1	ITMPENLGHKRtGsNIsGAssDIsLDEQyKHQLEETKKEKR
P22314	S46	Sugiyama	UBA1 A1S9T UBE1	AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22466	S116	Sugiyama	GAL GAL1 GALN GLNN	FLHLKEAGALDRLLDLPAAAssEDIERs_____________
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626	S324	Sugiyama	HNRNPA2B1 HNRPA2B1	GNYNQQPSNYGPMKsGNFGGsRNMGGPyGGGNyGPGGsGGs
P23284	S150	Sugiyama	PPIB CYPB	LKHyGPGWVsMANAGKDTNGsQFFITTVKTAWLDGKHVVFG
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P24534	S174	Sugiyama	EEF1B2 EEF1B EF1B	DMAKLEECVRsIQADGLVWGssKLVPVGyGIKKLQIQCVVE
P24539	S142	Sugiyama	ATP5PB ATP5F1	DFADKLNEQKLAQLEEAKQAsIQHIQNAIDTEKsQQALVQK
P24844	S20	PSP	MYL9 MLC2 MRLC1 MYRL2	_MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25705	S198	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	GIIPRIsVREPMQTGIKAVDsLVPIGRGQRELIIGDRQTGK
P25815	S24	Sugiyama	S100P S100E	LETAMGMIIDVFSRYSGSEGstQtLTKGELKVLMEKELPGF
P26038	S144	Sugiyama	MSN	LLASyAVQSKYGDFNKEVHKsGYLAGDKLLPQRVLEQHKLN
P26232	S667	Sugiyama	CTNNA2 CAPR	YDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEEKAKIAEQV
P26373	S106	Sugiyama	RPL13 BBC1 OK/SW-cl.46	IHKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLIL
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T107	Sugiyama	RPL13 BBC1 OK/SW-cl.46	HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27816	S1073	ELM	MAP4	DVKIEsQKLNFKEKAQAKVGsLDNVGHLPAGGAVKTEGGGS
P27816	S941	ELM	MAP4	SRLAtNtsAPDLKNVRsKVGstENIKHQPGGGRAKVEKKTE
P28066	S180	Sugiyama	PSMA5	GtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEAIKSSLI
P28838	S180	Sugiyama	LAP3 LAPEP PEPS	YEYDDLKQKKKMAVSAKLyGsGDQEAWQKGVLFAsGQNLAR
P29144	S176	Sugiyama	TPP2	FDVANNGSsQANKLIKEELQsQVELLNsFEKKYSDPGPVYD
P29692	S44	Sugiyama	EEF1D EF1D	RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P30048	S199	Sugiyama	PRDX3 AOP1	SGLALRGLFIIDPNGVIKHLsVNDLPVGRSVEETLRLVKAF
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30086	S54	Sugiyama	PEBP1 PBP PEBP	VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP
P30533	S230	Sugiyama	LRPAP1 A2MRAP	SDIKGSVLHSRHTELKEKLRsINQGLDRLRRVsHQGystEA
P30622	S195	Sugiyama	CLIP1 CYLN1 RSN	AAKEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELKIG
P30622	S197	Sugiyama	CLIP1 CYLN1 RSN	KEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELKIGDR
P31150	S316	Sugiyama	GDI1 GDIL OPHN2 RABGDIA XAP4	QVIRIICILSHPIKNtNDANsCQIIIPQNQVNRKSDIYVCM
P31327	S205	Sugiyama	CPS1	FEGQPVDFVDPNKQNLIAEVstKDVKVYGKGNPTKVVAVDC
P31327	S537	Sugiyama	CPS1	GVELFKRGVLKEYGVKVLGtsVEsIMATEDRQLFSDKLNEI
P31327	S835	Sugiyama	CPS1	MCHPsIEGFTPRLPMNKEWPsNLDLRKELSEPSsTRIyAIA
P31327	T536	Sugiyama	CPS1	CGVELFKRGVLKEYGVKVLGtsVEsIMATEDRQLFSDKLNE
P34897	S81	Sugiyama	SHMT2	QREKDRQCRGLELIAsENFCsRAALEALGsCLNNKYSEGYP
P34897	S90	Sugiyama	SHMT2	GLELIAsENFCsRAALEALGsCLNNKYSEGYPGKRyyGGAE
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932	S363	Sugiyama	HSPA4 APG2 HSPH2	GATRIPAVKEKISKFFGKELsttLNADEAVTRGCALQCAIL
P35221	S668	Sugiyama	CTNNA1	FDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEQKAKIAEQV
P35241	S532	Sugiyama	RDX	EERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHA
P35241	S533	Sugiyama	RDX	ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35250	S85	Sugiyama	RFC2	REGNVPNIIIAGPPGTGKTTsILCLARALLGPALKDAMLEL
P35579	S1943	Sugiyama	MYH9	RGDLPFVVPRRMARKGAGDGsDEEVDGKADGAEAKPAE___
P35606	S350	Sugiyama	COPB2	MGDAEIKDGERLPLAVKDMGsCEIyPQtIQHNPNGRFVVVC
P36578	S365	Sugiyama	RPL4 RPL1	RNHKLRVDKAAAAAAALQAKsDEKAAVAGKKPVVGKKGKKA
P37108	S25	Sugiyama	SRP14	EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646	S549	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	IVHVSAKDKGTGREQQIVIQssGGLsKDDIENMVKNAEKYA
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T398	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39748	S255	Sugiyama	FEN1 RAD2	CESIRGIGPKRAVDLIQKHKsIEEIVRRLDPNKYPVPENWL
P40818	S718	Sugiyama	USP8 KIAA0055 UBPY	AKPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtP
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P43034	S152	Sugiyama	PAFAH1B1 LIS1 MDCR MDS PAFAHA	IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013	S1098	Sugiyama	MKI67	PAARVTGMKKWPRtPKEEAQsLEDLAGFKELFQtPGPsEEs
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46779	S115	Sugiyama	RPL28	HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P46939	S1258	SIGNOR\|EPSD\|PSP	UTRN DMDL DRP1	LLHYLDLETTWLNTLEERMKsTEVLPEKTDAVNEALESLES
P46940	S1448	Sugiyama	IQGAP1 KIAA0051	AIRDAKTPDKMKKsKsVKEDsNLtLQEKKEKIQTGLKKLTE
P46940	S482	Sugiyama	IQGAP1 KIAA0051	LINRALESGDVNTVWKQLsssVtGLTNIEEENCQRYLDELM
P46940	T484	Sugiyama	IQGAP1 KIAA0051	NRALESGDVNTVWKQLsssVtGLTNIEEENCQRYLDELMKL
P47712	S729	Sugiyama	PLA2G4A CPLA2 PLA2G4	KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321	S662	Sugiyama	NASP	LKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsstsGF
P49327	S265	Sugiyama	FASN FAS	TILNAGTNTDGFKEQGVtFPsGDIQEQLIRSLyQsAGVAPE
P49368	S458	Sugiyama	CCT3 CCTG TRIC5	RAVAQALEVIPRTLIQNCGAstIRLLtSLRAKHtQENCEtW
P49588	S627	Sugiyama	AARS1 AARS	ATHILNFALRSVLGEADQKGsLVAPDRLRFDFTAKGAMSTQ
P49588	S775	Sugiyama	AARS1 AARS	VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P49736	S170	Sugiyama	MCM2 BM28 CCNL1 CDCL1 KIAA0030	KRRQVERAtEDGEEDEEMIEsIENLEDLKGHSVREWVsMAG
P49790	S607	Sugiyama	NUP153	KtPPEDCEGPFRPAEILKEGsVLDILKsPGFAsPKIDSVAA
P50395	S316	Sugiyama	GDI2 RABGDIB	QVIRVICILSHPIKNtNDANsCQIIIPQNQVNRKSDIyVCM
P50395	S396	Sugiyama	GDI2 RABGDIB	IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50395	T425	Sugiyama	GDI2 RABGDIB	DAttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED
P50542	S167	Sugiyama	PEX5 PXR1	EVTDPLSVSPARWAEEyLEQsEEKLWLGEPEGTATDRWYDE
P50990	S373	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	SEVGDTQVVVFKHEKEDGAIstIVLRGstDNLMDDIERAVD
P50990	S380	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	VVVFKHEKEDGAIstIVLRGstDNLMDDIERAVDDGVNtFK
P50990	T381	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	VVFKHEKEDGAIstIVLRGstDNLMDDIERAVDDGVNtFKV
P50993	S367	Sugiyama	ATP1A2 KIAA0778	KRMARKNCLVKNLEAVETLGstsTICSDKTGTLTQNRMTVA
P51946	S15	Sugiyama	CCNH	______MYHNsSQKRHWtFSsEEQLARLRADANRKFRCKAV
P51991	S375	Sugiyama	HNRNPA3 HNRPA3	ssGsPyGGGyGsGGGsGGyGsRRF_________________
P52272	S365	Sugiyama	HNRNPM HNRPM NAGR1	KMGGMEGPFGGGMENMGRFGsGMNMGRINEILsNALKRGEI
P52272	S528	Sugiyama	HNRNPM HNRPM NAGR1	IERMGsGVERMGPAIERMGLsMERMVPAGMGAGLERMGPVM
P52298	S13	Sugiyama	NCBP2 CBP20 PIG55	________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52597	S161	Sugiyama	HNRNPF HNRPF	ITLPVDPEGKITGEAFVQFAsQELAEKALGKHKERIGHRYI
P52597	S186	Sugiyama	HNRNPF HNRPF	EKALGKHKERIGHRYIEVFKssQEEVRsysDPPLKFMsVQR
P52597	S187	Sugiyama	HNRNPF HNRPF	KALGKHKERIGHRYIEVFKssQEEVRsysDPPLKFMsVQRP
P52597	S63	Sugiyama	HNRNPF HNRPF	VHFIYTREGRQsGEAFVELGsEDDVKMALKKDRESMGHRyI
P52788	S57	Sugiyama	SMS	ESVHTWQDHGYLATYTNKNGsFANLRIYPHGLVLLDLQSYD
P53621	S389	Sugiyama	COPA	SYNPAENAVLLCTRAsNLENstyDLytIPKDADsQNPDAPE
P53621	Y391	Sugiyama	COPA	NPAENAVLLCTRAsNLENstyDLytIPKDADsQNPDAPEGK
P53999	S17	Sugiyama	SUB1 PC4 RPO2TC1	____MPKSKELVsssssGsDsDsEVDKKLKRKKQVAPEKPV
P54105	S42	Sugiyama	CLNS1A CLCI ICLN	DTEAVLNGKGLGtGtLyIAEsRLSWLDGsGLGFSLEYPTIS
P54252	S260	Sugiyama	ATXN3 ATX3 MJD MJD1 SCA3	IDMEDEEADLRRAIQLsMQGssRNIsQDMtQtsGTNLTSEE
P54577	S366	Sugiyama	YARS1 YARS	KQKPMAKGPAKNsEPEEVIPsRLDIRVGKIITVEKHPDADs
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55036	S266	Sugiyama	PSMD4 MCB1	AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55060	S931	Sugiyama	CSE1L CAS XPO2	KKEHDPVGQMVNNPKIHLAQsLHKLSTACPGRVPSMVSTSL
P55769	S122	Sugiyama	SNU13 NHP2L1	CSVTIKEGSQLKQQIQsIQQsIERLLV______________
P55854	S27	Sugiyama	SUMO3 SMT3A SMT3H1	KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P55957	S78	Sugiyama	BID	QtDGNRssHsRLGRIEADsEsQEDIIRNIARHLAQVGDsMD
P56524	S246	EPSD\|PSP	HDAC4 KIAA0288	NHPVLGMYDAKDDFPLRKTAsEPNLKLRSRLKQKVAERRss
P56524	S467	PSP	HDAC4 KIAA0288	DRVSPSIHKLRQHRPLGRtQsAPLPQNAQALQHLVIQQQHQ
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174	T217	Sugiyama	TPI1 TPI	VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60709	S239	Sugiyama	ACTB	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60891	S11	Sugiyama	PRPS1	__________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P60900	S175	Sugiyama	PSMA6 PROS27	DPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTV
P61081	S175	Sugiyama	UBE2M UBC12	NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61163	T248	Sugiyama	ACTR1A CTRN1	PQKDETLETEKAQyyLPDGstIEIGPSRFRAPELLFRPDLI
P61313	S97	Sugiyama	RPL15 EC45 TCBAP0781	KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61326	S106	Sugiyama	MAGOH MAGOHA	QELEIVIGDEHISFTTSKIGsLIDVNQSKDPEGLRVFYYLV
P61956	S28	Sugiyama	SUMO2 SMT3B SMT3H2	EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P61978	S401	Sugiyama	HNRNPK HNRPK	GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978	T70	Sugiyama	HNRNPK HNRPK	QSKNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsI
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S156	Sugiyama	YWHAE	AtGNDRKEAAENsLVAyKAAsDIAMtELPPTHPIRLGLALN
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736	S241	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62979	S57	Sugiyama	RPS27A UBA80 UBCEP1	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987	S57	Sugiyama	UBA52 UBCEP2	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63220	S65	Sugiyama	RPS21	RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63220	S68	Sugiyama	RPS21	GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261	S239	Sugiyama	ACTG1 ACTG	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63267	S240	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S241	Sugiyama	ACTC1 ACTC	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S241	Sugiyama	ACTA1 ACTA	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P78352	S561	EPSD\|PSP	DLG4 PSD95	GPTKDRANDDLLSEFPDKFGsCVPHTTRPKREYEIDGRDYH
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731	S86	Sugiyama	RPL24	EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731	T83	Sugiyama	RPL24	QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098	S13	Sugiyama	RPL19	________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEIA
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00587	S350	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	HyPEMDARQERVEVLPQARAsWEsLDEEWRAPQAGsRtPVP
Q00610	S1462	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	VKQLPLVKPYLRSVQNHNNKsVNEsLNNLFITEEDyQALRT
Q00610	S1466	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	PLVKPYLRSVQNHNNKsVNEsLNNLFITEEDyQALRTsIDA
Q00613	S375	Sugiyama	HSF1 HSTF1	TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q00688	S100	Sugiyama	FKBP3 FKBP25	KVSEQVKNVKLNEDKPKEtKsEEtLDEGPPKYTKSVLKKGD
Q00688	S34	Sugiyama	FKBP3 FKBP25	QLRSEQLPKKDIIKFLQEHGsDsFLAEHKLLGNIKNVAKTA
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01082	S2048	Sugiyama	SPTBN1 SPTB2	VAEAWLLGQEPyLssREIGQsVDEVEKLIKRHEAFEKSAAT
Q01105	S161	Sugiyama	SET	FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01581	S404	Sugiyama	HMGCS1 HMGCS	YSLKVTQDATPGSALDKITAsLCDLKSRLDSRTGVAPDVFA
Q01650	S31	Sugiyama	SLC7A5 CD98LC LAT1 MPE16	LAAPAAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNIT
Q01970	S1041	Sugiyama	PLCB3	TKEGEDEAKRYQEFQNRQVQsLLELREAQVDAEAQRRLEHL
Q02818	S224	Sugiyama	NUCB1 NUC	RKLEEQQRRHREHPKVNVPGsQAQLKEVWEELDGLDPNRFN
Q02878	S255	Sugiyama	RPL6 TXREB1	tEKEKYEITEQRKIDQKAVDsQILPKIKAIPQLQGYLRSVF
Q04637	S1238	Sugiyama	EIF4G1 EIF4F EIF4G EIF4GI	RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q04721	S1621	Sugiyama	NOTCH2	KKQRMTRRSLPGEQEQEVAGsKVFLEIDNRQCVQDSDHCFK
Q04726	S622	Sugiyama	TLE3 KIAA1547	VWDLHNQTLVRQFQGHTDGAsCIDISHDGTKLWTGGLDNTV
Q05397	Y397	PSP	PTK2 FAK FAK1	ANSEKQGMRtHAVsVsEtDDyAEIIDEEDtytMPSTRDYEI
Q06210	S261	Sugiyama	GFPT1 GFAT GFPT	GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06830	S152	Sugiyama	PRDX1 PAGA PAGB TDPX2	IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q06830	T143	Sugiyama	PRDX1 PAGA PAGB TDPX2	EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07021	S164	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	DGEEEPSQGQKVEEQEPELtstPNFVVEVIKNDDGKKALVL
Q07021	S213	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	VGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDSLDW
Q07021	T165	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	GEEEPSQGQKVEEQEPELtstPNFVVEVIKNDDGKKALVLD
Q07065	S433	Sugiyama	CKAP4	LQHVEDGVLSMQVASARQTEsLESLLSKSQEHEQRLAALQG
Q08AD1	S464	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q09028	S146	Sugiyama	RBBP4 RBAP48	EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09028	S147	Sugiyama	RBBP4 RBAP48	VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q10471	S536	Sugiyama	GALNT2	NDSRQKWEQIEGNSKLRHVGsNLCLDSRTAKSGGLSVEVCG
Q12888	S1618	Sugiyama	TP53BP1	EQYGLGPYEAVtPLtKAADIsLDNLVEGKRKRRsNVssPAt
Q12931	S361	Sugiyama	TRAP1 HSP75 HSPC5	SIFYVPDMKPSMFDVSRELGsSVALYSRKVLIQTKATDILP
Q13098	S483	Sugiyama	GPS1 COPS1 CSN1	QIHVKsPPREGsQGELtPANsQsRMstNM____________
Q13136	S338	Sugiyama	PPFIA1 LIP1	MEERITTLEKRYLAAQREATsVHDLNDKLENEIANKDSMHR
Q13136	S668	Sugiyama	PPFIA1 LIP1	EEKENTEQRAEEIESRVGsGsLDNLGRFRSMssIPPYPAss
Q13136	S763	Sugiyama	PPFIA1 LIP1	PssPRALRLDRLHKGALHtVsHEDIRDIRNstGsQDGPVSN
Q13188	S15	PSP	STK3 KRS1 MST2	______MEQPPAPKSKLKKLsEDsLtKQPEEVFDVLEKLGE
Q13243	S153	Sugiyama	SRSF5 HRS SFRS5 SRP40	EVTFADAHRPKLNEGVVEFAsYGDLKNAIEKLSGKEINGRK
Q13263	S784	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13283	S362	Sugiyama	G3BP1 G3BP	LFIGNLPHEVDKSELKDFFQsyGNVVELRINsGGKLPNFGF
Q13347	S217	Sugiyama	EIF3I EIF3S2 TRIP1	sRDMtMFVtASKDNTAKLFDsttLEHQKTFRTERPVNSAAL
Q13470	S502	SIGNOR	TNK1	PPARGQRRNMPLERMKGIsRsLEsVLsLGPRPtGGGssPPE
Q13509	S115	Sugiyama	TUBB3 TUBB4	SGAGNNWAKGHytEGAELVDsVLDVVRKECENCDCLQGFQL
Q13625	S480	Sugiyama	TP53BP2 ASPP2 BBP	FDAVDQSNAPPSFGTLRKNQssEDILRDAQVANKNVAKVPP
Q13733	S377	Sugiyama	ATP1A4 ATP1AL2	KRMARKNCLVKNLEAVETLGstsTICSDKTGTLTQNRMTVA
Q13765	S186	Sugiyama	NACA HSD48	sEEEEVDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDI
Q13885	S115	Sugiyama	TUBB2A TUBB2	sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q14152	S492	Sugiyama	EIF3A EIF3S10 KIAA0139	VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14258	S340	Sugiyama	TRIM25 EFP RNF147 ZNF147	KPVYIPEVELNHKLIKGIHQstIDLKNELKQCIGRLQEPTP
Q14432	T311	Sugiyama	PDE3A	RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14498	S334	Sugiyama	RBM39 HCC1 RNPC2	FELAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtT
Q14568	S164	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	VAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGT
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568	S53	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14738	S598	Sugiyama	PPP2R5D	DVyTIKALEAHKRAEEFLTAsQEAL________________
Q14789	S1568	Sugiyama	GOLGB1	RDKLITEMDRSLLENQSLSssCEsLKLALEGLTEDKEKLVK
Q14980	S1181	Sugiyama	NUMA1 NMP22 NUMA	DsALEtLQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQD
Q15075	S359	Sugiyama	EEA1 ZFYVE2	LHQKDLDCQQLQsRLsAsEtsLHRIHVELSEKGEATQKLKE
Q15084	S377	Sugiyama	PDIA6 ERP5 P5 TXNDC7	PAMAAINARKMKFALLKGsFsEQGINEFLRELsFGRGstAP
Q15121	S116	Sugiyama	PEA15	DtKLtRIPsAKKYKDIIRQPsEEEIIKLAPPPKKA______
Q15185	S113	Sugiyama	PTGES3 P23 TEBP	RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15185	S85	Sugiyama	PTGES3 P23 TEBP	KHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVDFNN
Q15276	S407	Sugiyama	RABEP1 RAB5EP RABPT5 RABPT5A	GDPFSKSDNDMFKDGLRRAQstDsLGtsGsLQSKALGYNYK
Q15276	T408	Sugiyama	RABEP1 RAB5EP RABPT5 RABPT5A	DPFSKSDNDMFKDGLRRAQstDsLGtsGsLQSKALGYNYKA
Q15293	S80	Sugiyama	RCN1 RCN	HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q15642	S296	Sugiyama	TRIP10 CIP4 STOT STP	FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15785	S8	Sugiyama	TOMM34 URCC3	_____________MAPKFPDsVEELRAAGNESFRNGQyAEA
Q16204	S325	Sugiyama	CCDC6 D10S170 TST1	QRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQGL
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16531	T1125	Sugiyama	DDB1 XAP1	MQEVVANLQYDDGSGMKREAtADDLIKVVEELtRIH_____
Q16576	S145	Sugiyama	RBBP7 RBAP46	EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576	S146	Sugiyama	RBBP7 RBAP46	VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16719	S443	Sugiyama	KYNU	VVCDKRNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsAET
Q16836	S196	Sugiyama	HADH HAD HAD1 HADHSC SCHAD	PVMKLVEVIKTPMTSQKTFEsLVDFSKALGKHPVSCKDTPG
Q3MII6	S506	Sugiyama	TBC1D25 OATL1	DHLATASQGPGGGGRLLRQAsLDGLQQLRDNMGSRRDPLVQ
Q3V6T2	S1702	Sugiyama	CCDC88A APE GRDN KIAA1212	TLQQFLEEsNKLTSVQIKsssQENLLDEVMKSLsVssDFLG
Q53EL6	S46	Sugiyama	PDCD4 H731	GDEENAGTEEIKNEINGNWIsAssINEARINAKAKRRLRKN
Q53ET0	S171	GPS6\|EPSD	CRTC2 TORC2	NFPAEKGQLFRLPSALNRtssDsALHtsVMNPsPQDtYPGP
Q53ET0	S274	GPS6\|EPSD	CRTC2 TORC2	PSPDQPANVPVLPPAMNtGGsLPDLTNLHFPPPLPTPLDPE
Q562R1	S240	Sugiyama	ACTBL2	VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q58FF8	S266	Sugiyama	HSP90AB2P HSP90BB	EEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVWKRDSRV
Q5JSH3	S565	Sugiyama	WDR44 RPH11	DYFNNMRMKYNtEGRVsPsPsQEsLsssKsDTDtGVCsGtD
Q5T035	S66	Sugiyama	FAM120A2P C9orf129	LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI
Q6EEV6	S28	Sugiyama	SUMO4 SMT3H4	EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC
Q6GYQ0	T798	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6NVY1	S381	Sugiyama	HIBCH	PADLKEVtEEDLNNHFKSLGsSDLKF_______________
Q6P1J9	S178	Sugiyama	CDC73 C1orf28 HRPT2	EGHKEGIVQTEQIRSLsEAMsVEKIAAIKAKIMAKKRSTIK
Q6P2E9	S967	Sugiyama	EDC4 HEDLS	PEDWPALIWQQQRELAELRHsQEELLQRLCTQLEGLQSTVT
Q6S8J3	S939	Sugiyama	POTEE A26C1A POTE2	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6WKZ4	S234	SIGNOR\|PSP	RAB11FIP1 RCP	KSKIKTLLsKSNLQKtPLsQsMsVLPTsKPEKVLLRPGDFQ
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q7KZI7	S40	Sugiyama	MARK2 EMK1	TLGHLDSKPssKSNMIRGRNsAtsADEQPHIGNyRLLKTIG
Q7KZI7	S400	EPSD\|PSP	MARK2 EMK1	sADLtNssAPsPsHKVQRsVsANPKQRRFsDQAAGPAIPTS
Q7KZI7	S43	Sugiyama	MARK2 EMK1	HLDSKPssKSNMIRGRNsAtsADEQPHIGNyRLLKTIGKGN
Q7KZI7	S448	Sugiyama	MARK2 EMK1	QSNNAENKRPEEDRESGRKAsstAKVPAsPLPGLERKKttP
Q7KZI7	S449	Sugiyama	MARK2 EMK1	SNNAENKRPEEDRESGRKAsstAKVPAsPLPGLERKKttPt
Q7KZI7	S456	Sugiyama	MARK2 EMK1	RPEEDRESGRKAsstAKVPAsPLPGLERKKttPtPstNSVL
Q7KZI7	S471	Sugiyama	MARK2 EMK1	AKVPAsPLPGLERKKttPtPstNSVLststNRsRNsPLLER
Q7KZI7	S486	Sugiyama	MARK2 EMK1	ttPtPstNSVLststNRsRNsPLLERAsLGQAsIQNGKDSL
Q7KZI7	S493	Sugiyama	MARK2 EMK1	NSVLststNRsRNsPLLERAsLGQAsIQNGKDSLTMPGSRA
Q7KZI7	S498	Sugiyama	MARK2 EMK1	tstNRsRNsPLLERAsLGQAsIQNGKDSLTMPGSRAstAsA
Q7KZI7	S514	Sugiyama	MARK2 EMK1	LGQAsIQNGKDSLTMPGSRAstAsASAAVSAARPRQHQKsM
Q7KZI7	S517	Sugiyama	MARK2 EMK1	AsIQNGKDSLTMPGSRAstAsASAAVSAARPRQHQKsMsAs
Q7KZI7	S551	Sugiyama	MARK2 EMK1	QKsMsAsVHPNKASGLPPTEsNCEVPRPstAPQRVPVAsPs
Q7KZI7	S569	Sugiyama	MARK2 EMK1	TEsNCEVPRPstAPQRVPVAsPsAHNIsssGGAPDRTNFPR
Q7KZI7	S571	Sugiyama	MARK2 EMK1	sNCEVPRPstAPQRVPVAsPsAHNIsssGGAPDRTNFPRGV
Q7KZI7	S576	Sugiyama	MARK2 EMK1	PRPstAPQRVPVAsPsAHNIsssGGAPDRTNFPRGVssRst
Q7KZI7	S578	Sugiyama	MARK2 EMK1	PstAPQRVPVAsPsAHNIsssGGAPDRTNFPRGVssRstFH
Q7KZI7	S592	Sugiyama	MARK2 EMK1	AHNIsssGGAPDRTNFPRGVssRstFHAGQLRQVRDQQNLP
Q7KZI7	S593	Sugiyama	MARK2 EMK1	HNIsssGGAPDRTNFPRGVssRstFHAGQLRQVRDQQNLPy
Q7KZI7	S595	Sugiyama	MARK2 EMK1	IsssGGAPDRTNFPRGVssRstFHAGQLRQVRDQQNLPyGV
Q7KZI7	S619	Sugiyama	MARK2 EMK1	AGQLRQVRDQQNLPyGVtPAsPsGHsQGRRGAsGsIFSKFT
Q7KZI7	S621	Sugiyama	MARK2 EMK1	QLRQVRDQQNLPyGVtPAsPsGHsQGRRGAsGsIFSKFTSK
Q7KZI7	S631	Sugiyama	MARK2 EMK1	LPyGVtPAsPsGHsQGRRGAsGsIFSKFTSKFVRRNLSFRF
Q7KZI7	S633	Sugiyama	MARK2 EMK1	yGVtPAsPsGHsQGRRGAsGsIFSKFTSKFVRRNLSFRFAR
Q7KZI7	S704	Sugiyama	MARK2 EMK1	EFREAKPRSLRFTWSMKTTSsMEPNEMMREIRKVLDANsCQ
Q7KZI7	S722	Sugiyama	MARK2 EMK1	TSsMEPNEMMREIRKVLDANsCQSELHEKYMLLCMHGTPGH
Q7KZI7	S759	Sugiyama	MARK2 EMK1	TPGHEDFVQWEMEVCKLPRLsLNGVRFKRISGTSMAFKNIA
Q7KZI7	S93	Sugiyama	MARK2 EMK1	ILTGKEVAVKIIDKTQLNSSsLQKLFREVRIMKVLNHPNIV
Q7KZI7	T42	Sugiyama	MARK2 EMK1	GHLDSKPssKSNMIRGRNsAtsADEQPHIGNyRLLKTIGKG
Q7KZI7	T450	Sugiyama	MARK2 EMK1	NNAENKRPEEDRESGRKAsstAKVPAsPLPGLERKKttPtP
Q7KZI7	T469	Sugiyama	MARK2 EMK1	stAKVPAsPLPGLERKKttPtPstNSVLststNRsRNsPLL
Q7KZI7	T515	Sugiyama	MARK2 EMK1	GQAsIQNGKDSLTMPGSRAstAsASAAVSAARPRQHQKsMs
Q7KZI7	T596	Sugiyama	MARK2 EMK1	sssGGAPDRTNFPRGVssRstFHAGQLRQVRDQQNLPyGVt
Q7KZI7	T616	Sugiyama	MARK2 EMK1	tFHAGQLRQVRDQQNLPyGVtPAsPsGHsQGRRGAsGsIFS
Q7KZI7	Y613	Sugiyama	MARK2 EMK1	sRstFHAGQLRQVRDQQNLPyGVtPAsPsGHsQGRRGAsGs
Q7L2H7	S367	Sugiyama	EIF3M HFLB5 PCID1 GA17 PNAS-125	WQQLyDTLNAWKQNLNKVKNsLLsLsDt_____________
Q7L804	S227	GPS6\|SIGNOR\|EPSD\|PSP	RAB11FIP2 KIAA0941	MKSKPKKPFLLGPQRLSsAHsMsDLSGSHMSSEKLKAGTIG
Q7Z2W4	S492	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	VQATGRIADDADPRVALVNDsLsDVtsTtssRVDDHDSEEI
Q7Z2W4	S494	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	ATGRIADDADPRVALVNDsLsDVtsTtssRVDDHDSEEICL
Q7Z417	S655	Sugiyama	NUFIP2 KIAA1321 PIG1	LGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsIWNL
Q7Z417	S671	Sugiyama	NUFIP2 KIAA1321 PIG1	DsWGsFDLRAAIVYHTKEMEsIWNLQKQDPKRIItyNEAMD
Q7Z460	S1193	Sugiyama	CLASP1 KIAA0622 MAST1	LNSEEIYSSLRGVTEAIEKFsFRsQEDLNEPIKRDGKKECD
Q7Z460	S545	Sugiyama	CLASP1 KIAA0622 MAST1	yHTLESSyQKALQSHLKNSDsIVsLPQsDRsssssQEsLNR
Q86TC9	S198	Sugiyama	MYPN MYOP	CKNHKSKLESQNKVMQENSssFsDLSERRERSSVPIPIPAD
Q86UF2	S140	Sugiyama	CTAGE6 CTAGE6P	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86V81	S239	Sugiyama	ALYREF ALY BEF THOC4	tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86V81	S8	Sugiyama	ALYREF ALY BEF THOC4	_____________MADKMDMsLDDIIKLNRSQRGGRGGGRG
Q86VQ1	S226	Sugiyama	GLCCI1	sCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQRSKQ
Q86W92	S636	Sugiyama	PPFIBP1 KIAA1230	RGGTRATAGPRLGWsRDLGQsNsDLDMPFAKWTKEQVCNWL
Q8IX94	S140	Sugiyama	CTAGE4	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8IZP0	S22	Sugiyama	ABI1 SSH3BP1	AELQMLLEEEIPSGKRALIEsyQNLTRVADyCENNyIQATD
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8TDD1	S644	Sugiyama	DDX54	sRPALQEKQPEKEEEEEAGEsVEDIFSEVVGRKRQRSGPNR
Q8TEW0	S144	EPSD\|PSP	PARD3 PAR3 PAR3A	EIEVTPSVLRANMPLHVRRssDPALIGLstsVsDsNFSSEE
Q8TEW0	S873	SIGNOR\|EPSD\|PSP	PARD3 PAR3 PAR3A	MDLGIADETKLNTVDDQKAGsPsRDVGPSLGLKKsssLEsL
Q8WU90	S351	Sugiyama	ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730	DIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLsEAs
Q8WU90	T348	Sugiyama	ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730	sVNDIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLs
Q8WUI4	S155	SIGNOR\|ELM\|EPSD\|PSP	HDAC7 HDAC7A	PPVPSLPSDPPEHFPLRKtVsEPNLKLRYKPKKSLERRKNP
Q8WWH5	S268	Sugiyama	TRUB1 PUS4	ECGGGFYIRSLVSDIGKELSsCANVLELTRTKQGPFTLEEH
Q8WWI1	S1423	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	IPKTEEAsSGFLPGDRNKsRsttELDDYSTNKNGNNKYLDQ
Q8WWI1	S1510	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	RsAsVNKEPVSLPGIMRRGEsLDNLDsPRSNSWRQPPWLNQ
Q8WWI1	S706	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	RLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQK
Q92609	S541	Sugiyama	TBC1D5 KIAA0210	EsMPVQLNKGLSSKNIsssPsVEsLPGGREFtGsPPssAtK
Q92973	S339	Sugiyama	TNPO1 KPNB2 MIP1 TRN	SDIDIILLKGDVEEDEtIPDsEQDIRPRFHRSRTVAQQHDE
Q92974	S143	EPSD\|PSP	ARHGEF2 KIAA0651 LFP40	AIyPsDsFRQsLLGsRRGRssLSLAKsVsttNIAGHFNDEs
Q92974	S172	EPSD\|PSP	ARHGEF2 KIAA0651 LFP40	ttNIAGHFNDEsPLGLRRILsQstDsLNMRNRTLsVESLID
Q92974	S174	Sugiyama	ARHGEF2 KIAA0651 LFP40	NIAGHFNDEsPLGLRRILsQstDsLNMRNRTLsVESLIDEA
Q92974	S186	EPSD\|PSP	ARHGEF2 KIAA0651 LFP40	GLRRILsQstDsLNMRNRTLsVESLIDEAEVIySELMSDFE
Q92974	S711	Sugiyama	ARHGEF2 KIAA0651 LFP40	sGGNtsPGVtANGEARTFNGsIELCRADsDssQRDRNGNQL
Q92974	S886	SIGNOR	ARHGEF2 KIAA0651 LFP40	TEPLPAEAPWARRPVDPRRRsLPAGDALyLsFNPPQPSRGT
Q92974	S960	SIGNOR	ARHGEF2 KIAA0651 LFP40	ssDPDtGsEEEGssRLsPPHsPRDFtRMQDIPEEtEsRDGE
Q96A72	S108	Sugiyama	MAGOHB MAGOH2	QELEIVIGDEHISFTTSKIGsLIDVNQSKDPEGLRVFYYLV
Q96CT7	S122	Sugiyama	CCDC124	DtLRRDHQLREAPDTAEKAKsHLEVPLEENVNRRVLEEGsV
Q96D15	S98	Sugiyama	RCN3 UNQ239/PRO272	ARLGRIVDRMDRAGDGDGWVsLAELRAWIAHTQQRHIRDsV
Q96N67	S1438	Sugiyama	DOCK7 KIAA1771	LGTYTIAsPPERsPsGsAFGsQENLRWRKDMTHWRQNTEKL
Q96P16	S285	Sugiyama	RPRD1A P15RS	YKRKLARVSLVRKELRSRIQsLPDLSRLPNVTGSHMHLPFA
Q96PK6	S520	Sugiyama	RBM14 SIP	AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q96PK6	S620	Sugiyama	RBM14 SIP	KRYGSDRRLAELsDYRRLsEsQLsFRRsPtKSSLDYRRLPD
Q96S59	S181	Sugiyama	RANBP9 RANBPM	QEtPLPRSWsPKDKFsYIGLsQNNLRVHYKGHGKTPKDAAS
Q96S59	S613	Sugiyama	RANBP9 RANBPM	DCDtEMEVDSsQLRRQLCGGsQAAIERMIHFGRELQAMSEQ
Q99426	S163	Sugiyama	TBCB CG22 CKAP1	AEAAQRLAEEKAQASSIPVGsRCEVRAAGQSPRRGTVMYVG
Q99613	S865	Sugiyama	EIF3C EIF3S8	HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99689	S58	EPSD\|PSP	FEZ1	LEDPSLSELENFSSEIISFKsMEDLVNEFDEKLNVCFRNYN
Q9BQL6	S253	Sugiyama	FERMT1 C20orf42 KIND1 URP1	DMYQPRSLVDKAKLNAGWLDsSRSLMEQGIQEDEQLLLRFK
Q9BS40	S41	Sugiyama	LXN	INyQQGTPHRVFEVQKVKQAsMEDIPGRGHKYHLKFAVEEI
Q9BT78	S18	Sugiyama	COPS4 CSN4	___MAAAVRQDLAQLMNSsGsHKDLAGKYRQILEKAIQLSG
Q9BVA1	S115	Sugiyama	TUBB2B	sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q9BW91	S343	Sugiyama	NUDT9 NUDT10 PSEC0099 UNQ3012/PRO9771	SHSQFIKLVAEKRDAHWSEDsEADCHAL_____________
Q9BX40	S165	Sugiyama	LSM14B C20orf40 FAM61B RAP55B	GFPSIPVGKsPMVEQAVQtGsADNLNAKKLLPGKGTTGTQL
Q9BXM7	T313	SIGNOR\|EPSD\|PSP	PINK1	VDYPDVLPSRLHPEGLGHGRtLFLVMKNYPCTLRQYLCVNT
Q9BYX7	S239	Sugiyama	POTEKP ACTBL3 FKSG30	VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BZ72	S644	Sugiyama	PITPNM2 KIAA1457 NIR3	SGGGGSSGGSSLESSRHLsRsNVDIPRSNGTEDPKRQLPRK
Q9C0C2	S1158	Sugiyama	TNKS1BP1 KIAA1741 TAB182	sPssKMEGGHFVPPGKttAGsVDWTDQLGLRNLEVssCVGs
Q9C0C7	S628	Sugiyama	AMBRA1 DCAF3 KIAA1736	SVPSSGSQLPPLERTEGQTPsSsRLELsssAsPQEERTVGV
Q9C0C7	S630	Sugiyama	AMBRA1 DCAF3 KIAA1736	PSSGSQLPPLERTEGQTPsSsRLELsssAsPQEERTVGVAF
Q9H0H5	S257	Sugiyama	RACGAP1 KIAA1478 MGCRACGAP	ETVPYWtRSRRKtGtLQPWNsDstLNSRQLEPRTETDsVGt
Q9H1H9	S1698	Sugiyama	KIF13A RBKIN	GsPSSQSIPEKNSKSLCRtGsCsELDACPSKISQPARGFCP
Q9H2G2	S340	Sugiyama	SLK KIAA0204 STK2	EEDEEEEtENsLPIPAsKRAssDLsIAssEEDKLsQNACIL
Q9H4P4	S254	EPSD\|PSP	RNF41 FLRF NRDP1 SBBI03	VESGCPASIVNELIENAHERsWPQGLATLETRQMNRRYYEN
Q9H7D7	S123	Sugiyama	WDR26 CDW2 MIP2 PRO0852	SSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLNQT
Q9H7E9	T40	Sugiyama	C8orf33	PCAsRGARLPGPVsSARNPstVCLCPEQPTCSNADSRAHPL
Q9HA77	S548	Sugiyama	CARS2 OK/SW-cl.10	TLRRGLTAHGINIKDRssttstWELLDQRTKDQKSAG____
Q9HAP6	S120	Sugiyama	LIN7B MALS2 VELI2 UNQ3116/PRO10200	DEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLKRGDQL
Q9HAU0	S410	Sugiyama	PLEKHA5 KIAA1686 PEPP2	NRPNTGPLytEADRVIQRtNsMQQLEQWIKIQKGRGHEEET
Q9HCN4	S301	Sugiyama	GPN1 MBDIN RPAP4 XAB1 HUSSY-23	ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD
Q9HCN8	S40	Sugiyama	SDF2L1 UNQ1941/PRO4424	ALLVPGGGAAKTGAELVTCGsVLKLLNTHHRVRLHSHDIKY
Q9NP61	S457	Sugiyama	ARFGAP3 ARFGAP1	sQADYETRARLERLsAsssIssADLFEEPRKQPAGNysLSS
Q9NPF0	S142	Sugiyama	CD320 8D6A UNQ198/PRO224	KKLRNCSRLACLAGELRCTLsDDCIPLTWRCDGHPDCPDSS
Q9NQT8	S1381	GPS6\|SIGNOR\|EPSD\|PSP	KIF13B GAKIN KIAA0639	QEVAVKEQLTGKGKLSRRsIssPNVNRLsGsRQDLIPsYSL
Q9NQT8	S1410	GPS6\|SIGNOR\|EPSD\|PSP	KIF13B GAKIN KIAA0639	GsRQDLIPsYSLGSNKGRWEsQQDVSQTTVSRGIAPAPALs
Q9NQX3	S303	Sugiyama	GPHN GPH KIAA1385	sCPtPKVQSRCSsKENILRAsHsAVDITKVARRHRMSPFPL
Q9NQX3	S305	Sugiyama	GPHN GPH KIAA1385	PtPKVQSRCSsKENILRAsHsAVDITKVARRHRMSPFPLTS
Q9NTJ3	S504	Sugiyama	SMC4 CAPC SMC4L1	ELMGFSKSVNEARSKMDVAQsELDIyLSRHNTAVSQLTKAK
Q9NUP9	S120	Sugiyama	LIN7C MALS3 VELI3	EEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLKRGDQL
Q9NW64	S142	Sugiyama	RBM22 ZC3H16 199G4	EREISNsDGTRPVGMLGKATsTsDMLLKLARTTPYYKRNRP
Q9NYB9	S22	Sugiyama	ABI2 ARGBPIA	AELQMLLEEEIPGGRRALFDsytNLERVADyCENNyIQSAD
Q9NZB2	S417	Sugiyama	FAM120A C9orf10 KIAA0183 OSSA	LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI
Q9P0L2	S766	Sugiyama	MARK1 KIAA1477 MARK	DARQDSLVQWEMEVCKLPRLsLNGVRFKRISGTSIAFKNIA
Q9P1Y5	S431	Sugiyama	CAMSAP3 KIAA1543	FGLDSDVDVVMGDPVLLRsVssDsLGPPRPAPARTPtQPPP
Q9P265	S203	Sugiyama	DIP2B KIAA1463	stsssASSTLSHGEVKGtsGsLADVFANtRIENFSAPPDVT
Q9UBU9	S223	Sugiyama	NXF1 TAP	ELKPEQVEQLKLIMSKRYDGsQQALDLKGLRSDPDLVAQNI
Q9UGU0	S1187	Sugiyama	TCF20 KIAA0292 SPBP	sDGLPNKGMELKHGSQKLQEsCWDLsRQTsPAKSSGPPGMS
Q9UGV2	S333	Sugiyama	NDRG3	MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UHR4	S354	Sugiyama	BAIAP2L1 IRTKS	TGLNMMKKQKVKTIFPHtAGsNKTLLSFAQGDVITLLIPEE
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UJF2	S803	Sugiyama	RASAL2 NGAP	NPVyHLNNPIPAMPKASIDssLENLSTAssRSQSNSEDFKL
Q9UNZ2	S189	Sugiyama	NSFL1C UBXN2C	AGEKRQHssQDVHVVLKLWKsGFsLDNGELRSyQDPsNAQF
Q9UPQ0	S201	Sugiyama	LIMCH1 KIAA1102	DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQ35	S1539	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ80	T377	Sugiyama	PA2G4 EBP1	LLQssAsRKtQKKKKKKAsKtAENAtsGEtLEENEAGD___
Q9UQB8	S366	EPSD\|PSP	BAIAP2	SVTPKNSYATtENKtLPRsssMAAGLERNGRMRVKAIFsHA
Q9UQL6	S259	EPSD\|PSP	HDAC5 KIAA0600	KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9Y262	S80	Sugiyama	EIF3L EIF3EIP EIF3S6IP HSPC021 HSPC025 MSTP005	HKTVSDLIDQKVYELQASRVssDVIDQKVyEIQDIyENSWT
Q9Y262	S81	Sugiyama	EIF3L EIF3EIP EIF3S6IP HSPC021 HSPC025 MSTP005	KTVSDLIDQKVYELQASRVssDVIDQKVyEIQDIyENSWTK
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2B0	T79	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	NPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGEQIDPs
Q9Y2L1	S633	Sugiyama	DIS3 KIAA1008 RRP44	LNKLAKILKKRRIEKGALTLssPEVRFHMDSETHDPIDLQT
Q9Y316	S91	Sugiyama	MEMO1 C2orf4 MEMO NS5ATP7 CGI-27	TRRIFILGPSHHVPLsRCALsSVDIYRTPLYDLRIDQKIYG
Q9Y3F4	S254	Sugiyama	STRAP MAWD UNRIP	EKEFLVAGGEDFKLyKyDyNsGEELEsyKGHFGPIHCVRFS
Q9Y3S2	S25	Sugiyama	ZNF330 NOA36	KTGARKKAENRREREKQLRAsRstIDLAKHPCNASMECDKC
Q9Y3S2	S27	Sugiyama	ZNF330 NOA36	GARKKAENRREREKQLRAsRstIDLAKHPCNASMECDKCQR
Q9Y3S2	T28	Sugiyama	ZNF330 NOA36	ARKKAENRREREKQLRAsRstIDLAKHPCNASMECDKCQRR
Q9Y450	S69	Sugiyama	HBS1L HBS1 KIAA1038	sVEPVEEyDyEDLKEssNsVsNHQLSGFDQARLYsCLDHMR
Q9Y490	S1535	Sugiyama	TLN1 KIAA1027 TLN	RTTNPTAKRQFVQSAKEVANsTANLVKTIKALDGAFTEENR
Q9Y4G6	S1537	Sugiyama	TLN2 KIAA0320	KTANPVAKRHFVQSAKEVANsTANLVKTIKALDGDFSEDNR
Q9Y4L1	S742	Sugiyama	HYOU1 GRP170 HSPH4 ORP150	KLQDLTLRDLEKQEREKAANsLEAFIFEtQDKLyQPEyQEV
Q9Y4L1	T750	Sugiyama	HYOU1 GRP170 HSPH4 ORP150	DLEKQEREKAANsLEAFIFEtQDKLyQPEyQEVsTEEQREE
Q9Y5K5	S133	Sugiyama	UCHL5 UCH37 AD-019 CGI-70	EFKEFSQSFDAAMKGLALsNsDVIRQVHNSFARQQMFEFDT
Q9Y696	S226	Sugiyama	CLIC4	RNFDIPKEMTGIWRYLtNAysRDEFtNtCPsDKEVEIAysD
Q9Y6E0	S400	Sugiyama	STK24 MST3 STK3	ISPLFAELKEKsQACGGNLGsIEELRGAIYLAEEACPGISD
Q9Y6Y8	T893	Sugiyama	SEC23IP MSTP053	GFISSLKSAWQTLNEFARAHtsstQLQEELEKVANQIKEEE

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Signal Transduction	R-HSA-162582	2.832934e-09	8.548
Mitotic Prometaphase	R-HSA-68877	3.559998e-08	7.449
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	9.318238e-08	7.031
Cell Cycle	R-HSA-1640170	9.832098e-08	7.007
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.735929e-07	6.563
Cell Cycle, Mitotic	R-HSA-69278	2.565409e-07	6.591
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.954158e-07	6.305
Amplification of signal from the kinetochores	R-HSA-141424	4.954158e-07	6.305
Mitotic Spindle Checkpoint	R-HSA-69618	4.729098e-07	6.325
Kinesins	R-HSA-983189	1.015725e-06	5.993
M Phase	R-HSA-68886	3.288949e-06	5.483
Cell Cycle Checkpoints	R-HSA-69620	5.256394e-06	5.279
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	6.477042e-06	5.189
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	7.534151e-06	5.123
Separation of Sister Chromatids	R-HSA-2467813	1.294366e-05	4.888
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.293970e-05	4.888
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.675340e-05	4.776
Interleukin-37 signaling	R-HSA-9008059	2.419337e-05	4.616
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	3.926634e-05	4.406
MyD88-independent TLR4 cascade	R-HSA-166166	4.989403e-05	4.302
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	4.989403e-05	4.302
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	4.834122e-05	4.316
Signaling by Hippo	R-HSA-2028269	9.862647e-05	4.006
Mitotic Anaphase	R-HSA-68882	1.101234e-04	3.958
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.224685e-04	3.912
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.251969e-04	3.902
Cytokine Signaling in Immune system	R-HSA-1280215	1.299608e-04	3.886
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.520316e-04	3.818
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.763488e-04	3.754
AURKA Activation by TPX2	R-HSA-8854518	2.233559e-04	3.651
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.174149e-04	3.663
Striated Muscle Contraction	R-HSA-390522	2.666859e-04	3.574
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.028826e-04	3.519
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.028826e-04	3.519
Signaling by RAF1 mutants	R-HSA-9656223	3.148013e-04	3.502
Apoptotic execution phase	R-HSA-75153	3.675345e-04	3.435
Post NMDA receptor activation events	R-HSA-438064	3.842533e-04	3.415
Muscle contraction	R-HSA-397014	3.894685e-04	3.410
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.257179e-04	3.371
Recycling pathway of L1	R-HSA-437239	4.572583e-04	3.340
Apoptosis	R-HSA-109581	4.926476e-04	3.307
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	6.070093e-04	3.217
Signaling by ALK in cancer	R-HSA-9700206	6.070093e-04	3.217
Cellular response to heat stress	R-HSA-3371556	6.568339e-04	3.183
Membrane Trafficking	R-HSA-199991	6.813702e-04	3.167
Regulation of TP53 Activity	R-HSA-5633007	7.117666e-04	3.148
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	7.489625e-04	3.126
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	7.787301e-04	3.109
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	8.667860e-04	3.062
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	9.459281e-04	3.024
Signaling downstream of RAS mutants	R-HSA-9649948	9.459281e-04	3.024
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	9.459281e-04	3.024
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	9.459736e-04	3.024
Signaling by RAS mutants	R-HSA-6802949	9.459281e-04	3.024
Programmed Cell Death	R-HSA-5357801	9.736713e-04	3.012
Golgi-to-ER retrograde transport	R-HSA-8856688	8.931416e-04	3.049
Centrosome maturation	R-HSA-380287	1.075649e-03	2.968
PKR-mediated signaling	R-HSA-9833482	1.091005e-03	2.962
MAP kinase activation	R-HSA-450294	1.160535e-03	2.935
Toll-like Receptor Cascades	R-HSA-168898	1.139511e-03	2.943
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.485612e-03	2.828
Intracellular signaling by second messengers	R-HSA-9006925	1.435588e-03	2.843
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	1.465603e-03	2.834
Mitotic G2-G2/M phases	R-HSA-453274	1.449193e-03	2.839
Signaling by Interleukins	R-HSA-449147	1.422505e-03	2.847
RET signaling	R-HSA-8853659	1.569581e-03	2.804
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.576383e-03	2.802
Integrin signaling	R-HSA-354192	1.707442e-03	2.768
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.702505e-03	2.769
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.817956e-03	2.740
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.817956e-03	2.740
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.832579e-03	2.737
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.850506e-03	2.733
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.915778e-03	2.718
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.966796e-03	2.706
Signaling by NTRKs	R-HSA-166520	1.969802e-03	2.706
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.004811e-03	2.698
Death Receptor Signaling	R-HSA-73887	2.075380e-03	2.683
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.081757e-03	2.682
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.251278e-03	2.648
Interleukin-17 signaling	R-HSA-448424	2.276178e-03	2.643
ISG15 antiviral mechanism	R-HSA-1169408	2.283278e-03	2.641
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.538406e-03	2.595
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.584976e-03	2.588
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.630637e-03	2.580
Heme signaling	R-HSA-9707616	3.038901e-03	2.517
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.061961e-03	2.514
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	3.290034e-03	2.483
G2/M Transition	R-HSA-69275	3.319531e-03	2.479
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.353295e-03	2.475
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.490406e-03	2.457
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.502842e-03	2.456
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.546486e-03	2.450
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	4.124607e-03	2.385
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	4.768368e-03	2.322
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.348293e-03	2.362
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.896277e-03	2.310
Signaling by ERBB2	R-HSA-1227986	4.779237e-03	2.321
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	5.011920e-03	2.300
MyD88 cascade initiated on plasma membrane	R-HSA-975871	4.580805e-03	2.339
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	4.580805e-03	2.339
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	4.580805e-03	2.339
Autophagy	R-HSA-9612973	4.266513e-03	2.370
Cellular responses to stimuli	R-HSA-8953897	5.098644e-03	2.293
ROBO receptors bind AKAP5	R-HSA-9010642	5.282559e-03	2.277
NRAGE signals death through JNK	R-HSA-193648	5.542427e-03	2.256
Intrinsic Pathway for Apoptosis	R-HSA-109606	5.542427e-03	2.256
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	5.926846e-03	2.227
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	5.926846e-03	2.227
TRP channels	R-HSA-3295583	6.894791e-03	2.161
Interferon Signaling	R-HSA-913531	6.444609e-03	2.191
Cellular responses to stress	R-HSA-2262752	7.007039e-03	2.154
Regulation of TP53 Expression and Degradation	R-HSA-6806003	7.082900e-03	2.150
Signaling by ALK	R-HSA-201556	7.082900e-03	2.150
PIP3 activates AKT signaling	R-HSA-1257604	7.193473e-03	2.143
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	7.601040e-03	2.119
AKT phosphorylates targets in the nucleus	R-HSA-198693	7.920610e-03	2.101
Aggrephagy	R-HSA-9646399	8.435413e-03	2.074
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	8.448336e-03	2.073
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	7.977473e-03	2.098
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	7.977473e-03	2.098
Cellular Senescence	R-HSA-2559583	8.332591e-03	2.079
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	8.030054e-03	2.095
Regulation of IFNG signaling	R-HSA-877312	8.593969e-03	2.066
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	8.574076e-03	2.067
PI3K/AKT Signaling in Cancer	R-HSA-2219528	9.274515e-03	2.033
Signaling by LTK	R-HSA-9842663	8.593969e-03	2.066
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.351646e-03	2.029
Repression of WNT target genes	R-HSA-4641265	8.593969e-03	2.066
Axon guidance	R-HSA-422475	9.121231e-03	2.040
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.164224e-03	2.038
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.511117e-03	2.022
Regulation of TP53 Degradation	R-HSA-6804757	9.705101e-03	2.013
Regulation of PTEN gene transcription	R-HSA-8943724	9.881082e-03	2.005
FLT3 Signaling	R-HSA-9607240	9.984256e-03	2.001
Nephrin family interactions	R-HSA-373753	1.044455e-02	1.981
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.048025e-02	1.980
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.106052e-02	1.956
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.106052e-02	1.956
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.106052e-02	1.956
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.106052e-02	1.956
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	1.123029e-02	1.950
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.113804e-02	1.953
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.154333e-02	1.938
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	1.166633e-02	1.933
Nervous system development	R-HSA-9675108	1.157123e-02	1.937
MAP2K and MAPK activation	R-HSA-5674135	1.174773e-02	1.930
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.174773e-02	1.930
Macroautophagy	R-HSA-1632852	1.257115e-02	1.901
Oxidative Stress Induced Senescence	R-HSA-2559580	1.269785e-02	1.896
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.289157e-02	1.890
L1CAM interactions	R-HSA-373760	1.301743e-02	1.885
Nuclear Receptor transcription pathway	R-HSA-383280	1.307013e-02	1.884
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.361551e-02	1.866
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	1.364019e-02	1.865
TRIF-mediated programmed cell death	R-HSA-2562578	1.480663e-02	1.830
HDMs demethylate histones	R-HSA-3214842	1.449539e-02	1.839
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.510410e-02	1.821
DNA Double-Strand Break Repair	R-HSA-5693532	1.416780e-02	1.849
Downregulation of ERBB2 signaling	R-HSA-8863795	1.534697e-02	1.814
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.480663e-02	1.830
Activation of BH3-only proteins	R-HSA-114452	1.534697e-02	1.814
Organelle biogenesis and maintenance	R-HSA-1852241	1.527030e-02	1.816
Oncogenic MAPK signaling	R-HSA-6802957	1.560070e-02	1.807
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.580672e-02	1.801
NGF-stimulated transcription	R-HSA-9031628	1.580672e-02	1.801
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.582414e-02	1.801
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.582414e-02	1.801
FOXO-mediated transcription	R-HSA-9614085	1.633970e-02	1.787
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.717504e-02	1.765
MAPK family signaling cascades	R-HSA-5683057	1.726994e-02	1.763
Cilium Assembly	R-HSA-5617833	1.737922e-02	1.760
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.986065e-02	1.702
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.986065e-02	1.702
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.986065e-02	1.702
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.986065e-02	1.702
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.986065e-02	1.702
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.986065e-02	1.702
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.986065e-02	1.702
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.986065e-02	1.702
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.986065e-02	1.702
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.986065e-02	1.702
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.986065e-02	1.702
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	1.836992e-02	1.736
Chaperone Mediated Autophagy	R-HSA-9613829	1.829047e-02	1.738
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.829047e-02	1.738
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.925382e-02	1.715
SARS-CoV-2-host interactions	R-HSA-9705683	2.111065e-02	1.675
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.120923e-02	1.673
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.129852e-02	1.672
Reduction of cytosolic Ca++ levels	R-HSA-418359	2.132088e-02	1.671
PI Metabolism	R-HSA-1483255	2.170677e-02	1.663
Calmodulin induced events	R-HSA-111933	2.186827e-02	1.660
CaM pathway	R-HSA-111997	2.186827e-02	1.660
TNF signaling	R-HSA-75893	2.286044e-02	1.641
Rab regulation of trafficking	R-HSA-9007101	2.345662e-02	1.630
Diseases of programmed cell death	R-HSA-9645723	2.354147e-02	1.628
HSF1-dependent transactivation	R-HSA-3371571	2.369651e-02	1.625
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.445731e-02	1.612
Voltage gated Potassium channels	R-HSA-1296072	2.546137e-02	1.594
Response of endothelial cells to shear stress	R-HSA-9860931	2.598654e-02	1.585
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.940632e-02	1.532
ALK mutants bind TKIs	R-HSA-9700645	2.940632e-02	1.532
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.798111e-02	1.553
Post-chaperonin tubulin folding pathway	R-HSA-389977	2.806862e-02	1.552
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.994101e-02	1.524
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.798111e-02	1.553
Platelet calcium homeostasis	R-HSA-418360	2.994101e-02	1.524
p75 NTR receptor-mediated signalling	R-HSA-193704	2.765358e-02	1.558
GP1b-IX-V activation signalling	R-HSA-430116	2.940632e-02	1.532
G2/M DNA damage checkpoint	R-HSA-69473	2.784767e-02	1.555
Ca-dependent events	R-HSA-111996	2.876768e-02	1.541
Interleukin-1 family signaling	R-HSA-446652	3.140245e-02	1.503
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.195890e-02	1.495
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.197338e-02	1.495
ERK/MAPK targets	R-HSA-198753	3.410707e-02	1.467
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	3.410707e-02	1.467
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	3.923044e-02	1.406
Regulation of the apoptosome activity	R-HSA-9627069	3.923044e-02	1.406
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.471049e-02	1.460
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.471049e-02	1.460
Formation of apoptosome	R-HSA-111458	3.923044e-02	1.406
Netrin-1 signaling	R-HSA-373752	3.737753e-02	1.427
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.880977e-02	1.411
Deubiquitination	R-HSA-5688426	3.448429e-02	1.462
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.588494e-02	1.445
Selective autophagy	R-HSA-9663891	3.994615e-02	1.399
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	3.937555e-02	1.405
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	3.451853e-02	1.462
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	4.004140e-02	1.397
CREB phosphorylation	R-HSA-199920	4.041940e-02	1.393
Evasion by RSV of host interferon responses	R-HSA-9833109	4.094949e-02	1.388
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.097002e-02	1.388
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.097002e-02	1.388
Myogenesis	R-HSA-525793	4.135136e-02	1.384
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	4.135136e-02	1.384
G alpha (12/13) signalling events	R-HSA-416482	4.140225e-02	1.383
Chromatin modifying enzymes	R-HSA-3247509	4.213380e-02	1.375
DNA Double Strand Break Response	R-HSA-5693606	4.247093e-02	1.372
Neuronal System	R-HSA-112316	4.330501e-02	1.363
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.407528e-02	1.356
PKMTs methylate histone lysines	R-HSA-3214841	4.418640e-02	1.355
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	4.509386e-02	1.346
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	4.509386e-02	1.346
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	5.083316e-02	1.294
Signaling by ERBB2 ECD mutants	R-HSA-9665348	4.783421e-02	1.320
Regulation of necroptotic cell death	R-HSA-5675482	5.444834e-02	1.264
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	5.444834e-02	1.264
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.444834e-02	1.264
Transport of the SLBP independent Mature mRNA	R-HSA-159227	5.444834e-02	1.264
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	4.690560e-02	1.329
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	5.080430e-02	1.294
mRNA Splicing - Major Pathway	R-HSA-72163	4.761796e-02	1.322
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.839391e-02	1.315
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.444834e-02	1.264
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	4.783421e-02	1.320
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	5.312241e-02	1.275
TCF dependent signaling in response to WNT	R-HSA-201681	5.128217e-02	1.290
Ovarian tumor domain proteases	R-HSA-5689896	5.235032e-02	1.281
Regulation of MECP2 expression and activity	R-HSA-9022692	5.444834e-02	1.264
RAF/MAP kinase cascade	R-HSA-5673001	5.362303e-02	1.271
Signaling by PTK6	R-HSA-8848021	4.989559e-02	1.302
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	4.989559e-02	1.302
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	5.304443e-02	1.275
Signaling by Nuclear Receptors	R-HSA-9006931	4.869455e-02	1.313
Cardiac conduction	R-HSA-5576891	5.038859e-02	1.298
Transport of connexons to the plasma membrane	R-HSA-190872	4.783421e-02	1.320
Transcriptional Regulation by MECP2	R-HSA-8986944	5.167490e-02	1.287
GRB7 events in ERBB2 signaling	R-HSA-1306955	5.465836e-02	1.262
IGF1R signaling cascade	R-HSA-2428924	5.507079e-02	1.259
MAPK1/MAPK3 signaling	R-HSA-5684996	5.527659e-02	1.257
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	5.533401e-02	1.257
RUNX3 regulates WNT signaling	R-HSA-8951430	5.533401e-02	1.257
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	5.533401e-02	1.257
p75NTR signals via NF-kB	R-HSA-193639	5.564958e-02	1.255
MTOR signalling	R-HSA-165159	5.643911e-02	1.248
Impaired BRCA2 binding to PALB2	R-HSA-9709603	5.736757e-02	1.241
MHC class II antigen presentation	R-HSA-2132295	5.778411e-02	1.238
Interleukin-12 signaling	R-HSA-9020591	5.810366e-02	1.236
Metabolism of non-coding RNA	R-HSA-194441	5.868983e-02	1.231
snRNP Assembly	R-HSA-191859	5.868983e-02	1.231
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	5.936435e-02	1.226
Signaling by WNT	R-HSA-195721	6.040015e-02	1.219
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	6.050060e-02	1.218
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.060583e-02	1.217
Cellular responses to mechanical stimuli	R-HSA-9855142	6.191335e-02	1.208
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	6.218293e-02	1.206
Resolution of D-Loop Structures	R-HSA-5693537	6.218293e-02	1.206
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	6.819457e-02	1.166
Signaling by TCF7L2 mutants	R-HSA-5339700	6.819457e-02	1.166
TRAF3 deficiency - HSE	R-HSA-5602571	6.819457e-02	1.166
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	7.847681e-02	1.105
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	7.847681e-02	1.105
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	7.847681e-02	1.105
RSK activation	R-HSA-444257	7.281545e-02	1.138
Regulation by c-FLIP	R-HSA-3371378	7.281545e-02	1.138
Dimerization of procaspase-8	R-HSA-69416	7.281545e-02	1.138
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	7.281545e-02	1.138
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	6.423878e-02	1.192
Mitotic Telophase/Cytokinesis	R-HSA-68884	6.423878e-02	1.192
Activation of RAC1	R-HSA-428540	6.423878e-02	1.192
Signaling by GSK3beta mutants	R-HSA-5339716	6.423878e-02	1.192
p75NTR recruits signalling complexes	R-HSA-209543	7.943530e-02	1.100
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	7.943530e-02	1.100
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	7.943530e-02	1.100
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	7.943530e-02	1.100
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	7.943530e-02	1.100
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	7.943530e-02	1.100
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	7.943530e-02	1.100
Prolonged ERK activation events	R-HSA-169893	6.757352e-02	1.170
Co-inhibition by CTLA4	R-HSA-389513	6.799603e-02	1.168
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.799603e-02	1.168
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.799603e-02	1.168
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.799603e-02	1.168
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.799603e-02	1.168
Downstream signaling of activated FGFR3	R-HSA-5654708	6.474774e-02	1.189
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	7.409037e-02	1.130
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	7.409037e-02	1.130
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	7.402864e-02	1.131
Signaling by EGFR	R-HSA-177929	7.618397e-02	1.118
Neurodegenerative Diseases	R-HSA-8863678	6.681935e-02	1.175
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	6.681935e-02	1.175
Cytochrome c-mediated apoptotic response	R-HSA-111461	6.423878e-02	1.192
DARPP-32 events	R-HSA-180024	6.474774e-02	1.189
Chromatin organization	R-HSA-4839726	6.519737e-02	1.186
Meiosis	R-HSA-1500620	7.563085e-02	1.121
Signaling by FGFR3	R-HSA-5654741	7.876405e-02	1.104
Interleukin-15 signaling	R-HSA-8983432	7.943530e-02	1.100
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	6.757352e-02	1.170
Interleukin-7 signaling	R-HSA-1266695	7.725406e-02	1.112
Negative regulation of MET activity	R-HSA-6807004	6.799603e-02	1.168
Ion homeostasis	R-HSA-5578775	7.618397e-02	1.118
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	6.423878e-02	1.192
Signaling by VEGF	R-HSA-194138	7.052077e-02	1.152
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.618397e-02	1.118
Sodium/Calcium exchangers	R-HSA-425561	6.423878e-02	1.192
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	6.762561e-02	1.170
Glycolysis	R-HSA-70171	7.643080e-02	1.117
DAG and IP3 signaling	R-HSA-1489509	7.876405e-02	1.104
Regulated Necrosis	R-HSA-5218859	7.944528e-02	1.100
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	7.968909e-02	1.099
Signalling to ERKs	R-HSA-187687	7.968909e-02	1.099
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.972746e-02	1.098
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	8.123649e-02	1.090
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	8.308002e-02	1.081
Nuclear Envelope Breakdown	R-HSA-2980766	8.369027e-02	1.077
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.422111e-02	1.075
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	8.422111e-02	1.075
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	8.422111e-02	1.075
Trafficking of AMPA receptors	R-HSA-399719	8.422111e-02	1.075
Downstream signal transduction	R-HSA-186763	8.422111e-02	1.075
mRNA Splicing	R-HSA-72172	8.472000e-02	1.072
Regulation of TNFR1 signaling	R-HSA-5357905	8.729275e-02	1.059
Signaling by TGFBR3	R-HSA-9839373	8.729275e-02	1.059
Diseases of DNA repair	R-HSA-9675135	8.729275e-02	1.059
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	8.786047e-02	1.056
Potassium Channels	R-HSA-1296071	8.810771e-02	1.055
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.979128e-02	1.047
Vesicle-mediated transport	R-HSA-5653656	9.041952e-02	1.044
Regulation of TP53 Expression	R-HSA-6804754	1.107744e-01	0.956
DSCAM interactions	R-HSA-376172	1.107744e-01	0.956
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	1.107744e-01	0.956
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	1.107744e-01	0.956
TWIK related potassium channel (TREK)	R-HSA-1299503	1.107744e-01	0.956
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	1.107744e-01	0.956
TRAIL signaling	R-HSA-75158	1.060079e-01	0.975
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	1.060079e-01	0.975
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.060079e-01	0.975
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	9.275405e-02	1.033
ARMS-mediated activation	R-HSA-170984	9.275405e-02	1.033
CASP8 activity is inhibited	R-HSA-5218900	9.275405e-02	1.033
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.149839e-01	0.939
MET activates RAP1 and RAC1	R-HSA-8875555	1.149839e-01	0.939
Folding of actin by CCT/TriC	R-HSA-390450	1.149839e-01	0.939
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	9.637726e-02	1.016
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.551183e-02	1.020
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.551183e-02	1.020
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.551183e-02	1.020
PKA activation	R-HSA-163615	1.114718e-01	0.953
PKA activation in glucagon signalling	R-HSA-164378	1.114718e-01	0.953
IPs transport between nucleus and cytosol	R-HSA-1855170	1.068435e-01	0.971
Vpr-mediated nuclear import of PICs	R-HSA-180910	9.994838e-02	1.000
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.193182e-01	0.923
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.111072e-01	0.954
Homology Directed Repair	R-HSA-5693538	9.202685e-02	1.036
Insulin receptor signalling cascade	R-HSA-74751	9.299604e-02	1.032
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	9.276384e-02	1.033
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.214342e-01	0.916
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.185928e-01	0.926
Signal attenuation	R-HSA-74749	1.149839e-01	0.939
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.068435e-01	0.971
Negative regulation of MAPK pathway	R-HSA-5675221	9.342506e-02	1.030
Transcriptional Regulation by TP53	R-HSA-3700989	1.176611e-01	0.929
Activation of the AP-1 family of transcription factors	R-HSA-450341	9.275405e-02	1.033
Interleukin-6 signaling	R-HSA-1059683	9.637726e-02	1.016
Regulation of IFNA/IFNB signaling	R-HSA-912694	1.064689e-01	0.973
Diseases of mitotic cell cycle	R-HSA-9675126	9.514062e-02	1.022
Apoptotic factor-mediated response	R-HSA-111471	1.114718e-01	0.953
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.008798e-01	0.996
Activation of ATR in response to replication stress	R-HSA-176187	1.068435e-01	0.971
Signaling by FGFR1 in disease	R-HSA-5655302	9.342506e-02	1.030
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.175077e-01	0.930
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.060079e-01	0.975
HDL assembly	R-HSA-8963896	1.149894e-01	0.939
DNA Repair	R-HSA-73894	9.187442e-02	1.037
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.140512e-01	0.943
Signaling by TGF-beta Receptor Complex	R-HSA-170834	9.441623e-02	1.025
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	1.060079e-01	0.975
FGFR1 mutant receptor activation	R-HSA-1839124	1.068435e-01	0.971
Co-stimulation by CD28	R-HSA-389356	1.060001e-01	0.975
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.068435e-01	0.971
Signaling by SCF-KIT	R-HSA-1433557	1.141150e-01	0.943
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	R-HSA-180897	1.107744e-01	0.956
Tandem pore domain potassium channels	R-HSA-1296346	1.149839e-01	0.939
Regulation of KIT signaling	R-HSA-1433559	1.149894e-01	0.939
Physiological factors	R-HSA-5578768	1.149894e-01	0.939
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.111072e-01	0.954
PLC beta mediated events	R-HSA-112043	1.182735e-01	0.927
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.089440e-01	0.963
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.008798e-01	0.996
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.193182e-01	0.923
Growth hormone receptor signaling	R-HSA-982772	1.214342e-01	0.916
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	9.275405e-02	1.033
Interleukin-12 family signaling	R-HSA-447115	9.485617e-02	1.023
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.068435e-01	0.971
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.149839e-01	0.939
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	9.637726e-02	1.016
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.229414e-01	0.910
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.229414e-01	0.910
PTEN Regulation	R-HSA-6807070	1.245126e-01	0.905
Unfolded Protein Response (UPR)	R-HSA-381119	1.245126e-01	0.905
Glucose metabolism	R-HSA-70326	1.252091e-01	0.902
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.268720e-01	0.897
Signaling by MET	R-HSA-6806834	1.268720e-01	0.897
PI3K Cascade	R-HSA-109704	1.268908e-01	0.897
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.280540e-01	0.893
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.281017e-01	0.892
Late endosomal microautophagy	R-HSA-9615710	1.281017e-01	0.892
PI-3K cascade:FGFR3	R-HSA-5654710	1.286938e-01	0.890
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.286938e-01	0.890
Rap1 signalling	R-HSA-392517	1.286938e-01	0.890
COPI-mediated anterograde transport	R-HSA-6807878	1.317950e-01	0.880
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.319177e-01	0.880
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.319177e-01	0.880
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.319177e-01	0.880
NPAS4 regulates expression of target genes	R-HSA-9768919	1.325477e-01	0.878
RAF activation	R-HSA-5673000	1.325477e-01	0.878
NOD1/2 Signaling Pathway	R-HSA-168638	1.325477e-01	0.878
Nuclear import of Rev protein	R-HSA-180746	1.325477e-01	0.878
DCC mediated attractive signaling	R-HSA-418885	1.351706e-01	0.869
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.351706e-01	0.869
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	1.351706e-01	0.869
Beta-catenin phosphorylation cascade	R-HSA-196299	1.351706e-01	0.869
Cell-extracellular matrix interactions	R-HSA-446353	1.351706e-01	0.869
Formation of the anterior neural plate	R-HSA-9823739	1.351706e-01	0.869
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.354372e-01	0.868
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.354372e-01	0.868
Interactions of Rev with host cellular proteins	R-HSA-177243	1.354372e-01	0.868
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.354671e-01	0.868
Processing of DNA double-strand break ends	R-HSA-5693607	1.358664e-01	0.867
PTK6 promotes HIF1A stabilization	R-HSA-8857538	1.367101e-01	0.864
Signaling by LTK in cancer	R-HSA-9842640	1.367101e-01	0.864
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.374144e-01	0.862
Plasma lipoprotein assembly	R-HSA-8963898	1.374144e-01	0.862
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.374144e-01	0.862
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	1.382795e-01	0.859
Semaphorin interactions	R-HSA-373755	1.382795e-01	0.859
IRS-mediated signalling	R-HSA-112399	1.384477e-01	0.859
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.384477e-01	0.859
RHOBTB3 ATPase cycle	R-HSA-9706019	1.392959e-01	0.856
Signaling by APC mutants	R-HSA-4839744	1.392959e-01	0.856
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.392959e-01	0.856
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.392959e-01	0.856
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.392959e-01	0.856
Formation of the posterior neural plate	R-HSA-9832991	1.392959e-01	0.856
ChREBP activates metabolic gene expression	R-HSA-163765	1.392959e-01	0.856
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.430020e-01	0.845
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.430020e-01	0.845
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.430020e-01	0.845
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.430020e-01	0.845
Signaling by TGFB family members	R-HSA-9006936	1.437816e-01	0.842
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.452147e-01	0.838
PERK regulates gene expression	R-HSA-381042	1.465091e-01	0.834
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.465091e-01	0.834
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.471099e-01	0.832
Estrogen-dependent gene expression	R-HSA-9018519	1.474572e-01	0.831
Mitotic Prophase	R-HSA-68875	1.476114e-01	0.831
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.479279e-01	0.830
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.583381e-01	0.800
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	2.088311e-01	0.680
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.088311e-01	0.680
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.088311e-01	0.680
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.088311e-01	0.680
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.700078e-01	0.770
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.700078e-01	0.770
PTK6 Expression	R-HSA-8849473	1.700078e-01	0.770
Cohesin Loading onto Chromatin	R-HSA-2470946	1.700078e-01	0.770
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.654501e-01	0.781
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.654501e-01	0.781
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	1.567986e-01	0.805
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	1.567986e-01	0.805
Phosphorylation of the APC/C	R-HSA-176412	1.567986e-01	0.805
SHC-related events triggered by IGF1R	R-HSA-2428933	1.931863e-01	0.714
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.797344e-01	0.745
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.797344e-01	0.745
Frs2-mediated activation	R-HSA-170968	2.222347e-01	0.653
FGFR3 mutant receptor activation	R-HSA-2033514	2.222347e-01	0.653
Signaling by activated point mutants of FGFR3	R-HSA-1839130	2.222347e-01	0.653
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.222347e-01	0.653
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.666396e-01	0.778
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.666396e-01	0.778
SHC-mediated cascade:FGFR3	R-HSA-5654704	1.666396e-01	0.778
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.543608e-01	0.811
FRS-mediated FGFR3 signaling	R-HSA-5654706	1.871911e-01	0.728
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.871911e-01	0.728
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.871911e-01	0.728
EGFR downregulation	R-HSA-182971	1.587159e-01	0.799
Notch-HLH transcription pathway	R-HSA-350054	2.086644e-01	0.681
Signaling by FGFR3 in disease	R-HSA-5655332	1.909161e-01	0.719
Interaction between L1 and Ankyrins	R-HSA-445095	1.909161e-01	0.719
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	2.102860e-01	0.677
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.062564e-01	0.686
Neutrophil degranulation	R-HSA-6798695	1.962690e-01	0.707
Circadian clock	R-HSA-9909396	1.577748e-01	0.802
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.696480e-01	0.770
HATs acetylate histones	R-HSA-3214847	1.576151e-01	0.802
Protein folding	R-HSA-391251	2.041375e-01	0.690
Chaperonin-mediated protein folding	R-HSA-390466	2.083420e-01	0.681
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.901171e-01	0.721
IRS-related events triggered by IGF1R	R-HSA-2428928	1.859193e-01	0.731
Signaling by FGFR4	R-HSA-5654743	1.916192e-01	0.718
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.214417e-01	0.655
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.088311e-01	0.680
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.871911e-01	0.728
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.102860e-01	0.677
Meiotic recombination	R-HSA-912446	2.195928e-01	0.658
G2/M Checkpoints	R-HSA-69481	2.175513e-01	0.662
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.088311e-01	0.680
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.053246e-01	0.688
Role of second messengers in netrin-1 signaling	R-HSA-418890	1.931863e-01	0.714
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.485767e-01	0.828
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.722163e-01	0.764
Signaling by FGFR in disease	R-HSA-1226099	1.925418e-01	0.715
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	2.086644e-01	0.681
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.827331e-01	0.738
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.722163e-01	0.764
Signaling by WNT in cancer	R-HSA-4791275	1.752008e-01	0.756
Ub-specific processing proteases	R-HSA-5689880	1.983363e-01	0.703
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.797344e-01	0.745
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.625878e-01	0.789
Signaling by NOTCH1	R-HSA-1980143	2.170018e-01	0.664
Neurexins and neuroligins	R-HSA-6794361	1.499054e-01	0.824
Cardiogenesis	R-HSA-9733709	1.924085e-01	0.716
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.765117e-01	0.753
ESR-mediated signaling	R-HSA-8939211	1.522476e-01	0.817
G-protein mediated events	R-HSA-112040	1.834495e-01	0.736
FasL/ CD95L signaling	R-HSA-75157	1.583381e-01	0.800
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	2.088311e-01	0.680
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.585111e-01	0.800
Signaling by PDGFR in disease	R-HSA-9671555	1.871911e-01	0.728
Protein-protein interactions at synapses	R-HSA-6794362	1.753208e-01	0.756
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	2.053246e-01	0.688
Smooth Muscle Contraction	R-HSA-445355	1.621786e-01	0.790
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.214417e-01	0.655
FLT3 signaling in disease	R-HSA-9682385	1.611747e-01	0.793
Platelet activation, signaling and aggregation	R-HSA-76002	1.764150e-01	0.753
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.766952e-01	0.753
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.583381e-01	0.800
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.583381e-01	0.800
Signaling by AMER1 mutants	R-HSA-4839748	1.654501e-01	0.781
Signaling by AXIN mutants	R-HSA-4839735	1.654501e-01	0.781
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.222347e-01	0.653
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.871911e-01	0.728
Phase 0 - rapid depolarisation	R-HSA-5576892	2.103889e-01	0.677
Gap junction trafficking and regulation	R-HSA-157858	1.901171e-01	0.721
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.752008e-01	0.756
Signaling by ERBB4	R-HSA-1236394	1.925418e-01	0.715
OAS antiviral response	R-HSA-8983711	1.931863e-01	0.714
Gap junction trafficking	R-HSA-190828	2.070777e-01	0.684
Maturation of nucleoprotein	R-HSA-9683610	2.222347e-01	0.653
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.797344e-01	0.745
SARS-CoV-2 Infection	R-HSA-9694516	1.874172e-01	0.727
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	2.259368e-01	0.646
Signaling by ROBO receptors	R-HSA-376176	2.267973e-01	0.644
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	2.268071e-01	0.644
Nucleotide Excision Repair	R-HSA-5696398	2.275120e-01	0.643
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.287759e-01	0.641
Gap junction assembly	R-HSA-190861	2.287759e-01	0.641
Ephrin signaling	R-HSA-3928664	2.289138e-01	0.640
Tie2 Signaling	R-HSA-210993	2.289138e-01	0.640
Platelet sensitization by LDL	R-HSA-432142	2.289138e-01	0.640
Interleukin receptor SHC signaling	R-HSA-912526	2.309527e-01	0.636
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.325546e-01	0.633
Hedgehog 'off' state	R-HSA-5610787	2.328039e-01	0.633
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.371916e-01	0.625
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.464397e-01	0.608
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.464397e-01	0.608
Diseases of Telomere Maintenance	R-HSA-9673013	2.464397e-01	0.608
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.464397e-01	0.608
Defective F8 binding to von Willebrand factor	R-HSA-9672393	2.464397e-01	0.608
TGFBR2 MSI Frameshift Mutants in Cancer	R-HSA-3642279	2.464397e-01	0.608
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.464397e-01	0.608
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.464397e-01	0.608
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.464397e-01	0.608
TWIK-related spinal cord K+ channel (TRESK)	R-HSA-1299344	2.464397e-01	0.608
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.464397e-01	0.608
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.464397e-01	0.608
TICAM1 deficiency - HSE	R-HSA-5602566	2.464397e-01	0.608
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.464397e-01	0.608
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.458591e-01	0.461
Signaling by FGFR3 fusions in cancer	R-HSA-8853334	3.458591e-01	0.461
NFG and proNGF binds to p75NTR	R-HSA-205017	3.458591e-01	0.461
Interactions of Tat with host cellular proteins	R-HSA-176034	3.458591e-01	0.461
t(4;14) translocations of FGFR3	R-HSA-2033515	3.458591e-01	0.461
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.458591e-01	0.461
XAV939 stabilizes AXIN	R-HSA-5545619	3.458591e-01	0.461
Defective APRT disrupts adenine salvage	R-HSA-9734195	3.458591e-01	0.461
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.458591e-01	0.461
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	3.458591e-01	0.461
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.458591e-01	0.461
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.458591e-01	0.461
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.458591e-01	0.461
Defective VWF binding to collagen type I	R-HSA-9845622	3.458591e-01	0.461
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	3.458591e-01	0.461
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.458591e-01	0.461
Intestinal infectious diseases	R-HSA-8942233	3.458591e-01	0.461
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	2.606537e-01	0.584
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.606537e-01	0.584
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.606537e-01	0.584
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.606537e-01	0.584
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.606537e-01	0.584
G2 Phase	R-HSA-68911	2.606537e-01	0.584
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.606537e-01	0.584
Defective F9 activation	R-HSA-9673221	2.606537e-01	0.584
Regulated proteolysis of p75NTR	R-HSA-193692	2.421062e-01	0.616
Lipophagy	R-HSA-9613354	2.421062e-01	0.616
WNT mediated activation of DVL	R-HSA-201688	2.421062e-01	0.616
Inactivation of CDC42 and RAC1	R-HSA-428543	2.421062e-01	0.616
MAPK1 (ERK2) activation	R-HSA-112411	2.421062e-01	0.616
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	3.125769e-01	0.505
CLEC7A/inflammasome pathway	R-HSA-5660668	3.125769e-01	0.505
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.125769e-01	0.505
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.125769e-01	0.505
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	3.125769e-01	0.505
PKB-mediated events	R-HSA-109703	3.125769e-01	0.505
PDE3B signalling	R-HSA-165160	3.125769e-01	0.505
IkBA variant leads to EDA-ID	R-HSA-5603029	3.125769e-01	0.505
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	3.125769e-01	0.505
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	4.321668e-01	0.364
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	4.321668e-01	0.364
Defective F8 cleavage by thrombin	R-HSA-9672391	4.321668e-01	0.364
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	4.321668e-01	0.364
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.321668e-01	0.364
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	4.321668e-01	0.364
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.321668e-01	0.364
Potassium transport channels	R-HSA-1296067	4.321668e-01	0.364
Essential pentosuria	R-HSA-5662853	4.321668e-01	0.364
STAT5 Activation	R-HSA-9645135	3.636728e-01	0.439
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	3.636728e-01	0.439
Activated NTRK3 signals through RAS	R-HSA-9034864	3.180435e-01	0.498
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.831842e-01	0.548
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.831842e-01	0.548
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.831842e-01	0.548
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.831842e-01	0.548
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.831842e-01	0.548
TRAF6 mediated NF-kB activation	R-HSA-933542	2.539448e-01	0.595
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.814163e-01	0.551
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.814163e-01	0.551
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	3.145611e-01	0.502
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.563115e-01	0.448
Activated NTRK2 signals through RAS	R-HSA-9026519	3.563115e-01	0.448
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	3.563115e-01	0.448
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.563115e-01	0.448
Activated NTRK2 signals through CDK5	R-HSA-9032845	4.132563e-01	0.384
Netrin mediated repulsion signals	R-HSA-418886	4.132563e-01	0.384
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	4.132563e-01	0.384
IFNG signaling activates MAPKs	R-HSA-9732724	4.132563e-01	0.384
SOS-mediated signalling	R-HSA-112412	4.132563e-01	0.384
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.132563e-01	0.384
Recycling of eIF2:GDP	R-HSA-72731	4.132563e-01	0.384
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	4.132563e-01	0.384
Downstream signaling of activated FGFR4	R-HSA-5654716	2.513442e-01	0.600
SWI/SNF chromatin remodelers	R-HSA-9932451	2.775267e-01	0.557
ATP-dependent chromatin remodelers	R-HSA-9932444	2.775267e-01	0.557
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.085008e-01	0.511
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.462111e-01	0.461
Signaling by EGFR in Cancer	R-HSA-1643713	3.015837e-01	0.521
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	3.015837e-01	0.521
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.942757e-01	0.404
Serotonin clearance from the synaptic cleft	R-HSA-380615	3.942757e-01	0.404
RUNX2 regulates bone development	R-HSA-8941326	2.673483e-01	0.573
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	2.394543e-01	0.621
Cristae formation	R-HSA-8949613	3.260017e-01	0.487
PI3K events in ERBB2 signaling	R-HSA-1963642	3.779089e-01	0.423
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	3.779089e-01	0.423
Type I hemidesmosome assembly	R-HSA-446107	4.608371e-01	0.336
FGFR1b ligand binding and activation	R-HSA-190370	4.608371e-01	0.336
Signaling by MRAS-complex mutants	R-HSA-9660537	4.608371e-01	0.336
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.608371e-01	0.336
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	2.560372e-01	0.592
Signaling by CSF3 (G-CSF)	R-HSA-9674555	3.754768e-01	0.425
Dual Incision in GG-NER	R-HSA-5696400	3.615739e-01	0.442
Downstream signaling of activated FGFR1	R-HSA-5654687	3.842895e-01	0.415
Downstream signaling of activated FGFR2	R-HSA-5654696	3.842895e-01	0.415
Activation of the pre-replicative complex	R-HSA-68962	4.003214e-01	0.398
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	4.406454e-01	0.356
IKK complex recruitment mediated by RIP1	R-HSA-937041	4.406454e-01	0.356
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	4.680997e-01	0.330
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	4.680997e-01	0.330
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	4.680997e-01	0.330
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	4.680997e-01	0.330
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	4.680997e-01	0.330
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	4.680997e-01	0.330
Meiotic synapsis	R-HSA-1221632	3.637875e-01	0.439
G1/S-Specific Transcription	R-HSA-69205	4.070387e-01	0.390
Lysosome Vesicle Biogenesis	R-HSA-432720	4.070387e-01	0.390
PI-3K cascade:FGFR4	R-HSA-5654720	4.713352e-01	0.327
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	3.424863e-01	0.465
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	3.424863e-01	0.465
Transcriptional regulation by RUNX2	R-HSA-8878166	3.364502e-01	0.473
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	3.944263e-01	0.404
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	3.553780e-01	0.449
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.947665e-01	0.404
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.947665e-01	0.404
Dual incision in TC-NER	R-HSA-6782135	4.569459e-01	0.340
Interferon gamma signaling	R-HSA-877300	2.380403e-01	0.623
Eukaryotic Translation Initiation	R-HSA-72613	4.743882e-01	0.324
Cap-dependent Translation Initiation	R-HSA-72737	4.743882e-01	0.324
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	2.618447e-01	0.582
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.358569e-01	0.474
Mitochondrial protein import	R-HSA-1268020	4.047375e-01	0.393
Interferon alpha/beta signaling	R-HSA-909733	4.611311e-01	0.336
Apoptosis induced DNA fragmentation	R-HSA-140342	2.798358e-01	0.553
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.316251e-01	0.365
Germ layer formation at gastrulation	R-HSA-9754189	2.548325e-01	0.594
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.394523e-01	0.469
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.394523e-01	0.469
trans-Golgi Network Vesicle Budding	R-HSA-199992	4.586304e-01	0.339
Signaling by FGFR	R-HSA-190236	3.764638e-01	0.424
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.047375e-01	0.393
Eukaryotic Translation Elongation	R-HSA-156842	3.734871e-01	0.428
G1/S Transition	R-HSA-69206	2.638175e-01	0.579
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.394523e-01	0.469
TGFBR3 expression	R-HSA-9839394	2.775267e-01	0.557
Signaling by FGFR2	R-HSA-5654738	3.664390e-01	0.436
TRAF6 mediated IRF7 activation	R-HSA-933541	2.873023e-01	0.542
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.484741e-01	0.605
Epigenetic regulation of gene expression	R-HSA-212165	4.346491e-01	0.362
EGFR Transactivation by Gastrin	R-HSA-2179392	2.798358e-01	0.553
Josephin domain DUBs	R-HSA-5689877	2.798358e-01	0.553
Triglyceride catabolism	R-HSA-163560	2.673483e-01	0.573
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.125769e-01	0.505
Regulation of CDH11 function	R-HSA-9762292	2.798358e-01	0.553
MET activates RAS signaling	R-HSA-8851805	3.942757e-01	0.404
Elevation of cytosolic Ca2+ levels	R-HSA-139853	3.779089e-01	0.423
G-protein beta:gamma signalling	R-HSA-397795	3.165619e-01	0.500
Attenuation phase	R-HSA-3371568	3.490411e-01	0.457
CRMPs in Sema3A signaling	R-HSA-399956	4.680997e-01	0.330
Clathrin-mediated endocytosis	R-HSA-8856828	2.753188e-01	0.560
Interleukin-2 family signaling	R-HSA-451927	3.490411e-01	0.457
Signaling by FGFR1	R-HSA-5654736	3.001750e-01	0.523
Listeria monocytogenes entry into host cells	R-HSA-8876384	3.359259e-01	0.474
Interleukin-9 signaling	R-HSA-8985947	4.608371e-01	0.336
Interleukin-6 family signaling	R-HSA-6783589	2.539448e-01	0.595
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.636728e-01	0.439
NF-kB is activated and signals survival	R-HSA-209560	3.563115e-01	0.448
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.608371e-01	0.336
Intraflagellar transport	R-HSA-5620924	2.735155e-01	0.563
Cyclin E associated events during G1/S transition	R-HSA-69202	3.147956e-01	0.502
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.622899e-01	0.581
rRNA processing in the nucleus and cytosol	R-HSA-8868773	3.993919e-01	0.399
Regulation of NPAS4 gene expression	R-HSA-9768759	3.779089e-01	0.423
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.636728e-01	0.439
Long-term potentiation	R-HSA-9620244	2.775267e-01	0.557
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	3.942757e-01	0.404
HSF1 activation	R-HSA-3371511	2.673483e-01	0.573
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.260017e-01	0.487
Signaling by Insulin receptor	R-HSA-74752	3.734871e-01	0.428
Cyclin D associated events in G1	R-HSA-69231	4.542819e-01	0.343
G1 Phase	R-HSA-69236	4.542819e-01	0.343
GPER1 signaling	R-HSA-9634597	3.965475e-01	0.402
Sema4D in semaphorin signaling	R-HSA-400685	2.775267e-01	0.557
Generic Transcription Pathway	R-HSA-212436	4.687796e-01	0.329
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	4.332901e-01	0.363
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.762701e-01	0.425
S Phase	R-HSA-69242	3.277323e-01	0.484
Regulation of NPAS4 gene transcription	R-HSA-9768777	2.421062e-01	0.616
Cellular response to mitochondrial stress	R-HSA-9840373	2.421062e-01	0.616
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	2.539448e-01	0.595
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.779089e-01	0.423
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.693817e-01	0.433
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.693817e-01	0.433
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.693817e-01	0.433
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.693817e-01	0.433
Defective pyroptosis	R-HSA-9710421	4.332901e-01	0.363
Signaling by Hedgehog	R-HSA-5358351	2.821310e-01	0.550
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	3.462111e-01	0.461
Negative regulation of FGFR4 signaling	R-HSA-5654733	3.754768e-01	0.425
Regulation of T cell activation by CD28 family	R-HSA-388841	2.823963e-01	0.549
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	2.974401e-01	0.527
Maternal to zygotic transition (MZT)	R-HSA-9816359	3.043129e-01	0.517
Ca2+ pathway	R-HSA-4086398	2.624405e-01	0.581
RSV-host interactions	R-HSA-9833110	3.791486e-01	0.421
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.462646e-01	0.461
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	2.775267e-01	0.557
Transcriptional Regulation by VENTX	R-HSA-8853884	2.437770e-01	0.613
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	3.910003e-01	0.408
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.523231e-01	0.598
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	3.636728e-01	0.439
WNT5A-dependent internalization of FZD4	R-HSA-5099900	3.145611e-01	0.502
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.132563e-01	0.384
Polo-like kinase mediated events	R-HSA-156711	4.094487e-01	0.388
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.797556e-01	0.553
Nuclear RNA decay	R-HSA-9930044	4.741187e-01	0.324
Negative regulation of FGFR1 signaling	R-HSA-5654726	4.741187e-01	0.324
Host Interactions of HIV factors	R-HSA-162909	2.427907e-01	0.615
RMTs methylate histone arginines	R-HSA-3214858	4.542819e-01	0.343
Opioid Signalling	R-HSA-111885	3.656617e-01	0.437
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.437770e-01	0.613
TBC/RABGAPs	R-HSA-8854214	2.991294e-01	0.524
Spry regulation of FGF signaling	R-HSA-1295596	2.831842e-01	0.548
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	3.462111e-01	0.461
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	4.730858e-01	0.325
Specification of the neural plate border	R-HSA-9834899	4.406454e-01	0.356
Metabolism of RNA	R-HSA-8953854	4.059704e-01	0.392
Formation of editosomes by ADAR proteins	R-HSA-77042	2.464397e-01	0.608
Inhibition of PKR	R-HSA-169131	2.464397e-01	0.608
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.458591e-01	0.461
Manipulation of host energy metabolism	R-HSA-9636667	3.458591e-01	0.461
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	3.125769e-01	0.505
mRNA Editing: A to I Conversion	R-HSA-75064	4.321668e-01	0.364
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.321668e-01	0.364
Regulation of cortical dendrite branching	R-HSA-8985801	4.321668e-01	0.364
C6 deamination of adenosine	R-HSA-75102	4.321668e-01	0.364
Influenza Virus Induced Apoptosis	R-HSA-168277	4.321668e-01	0.364
Negative regulation of FLT3	R-HSA-9706369	3.145611e-01	0.502
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	3.145611e-01	0.502
Phase 4 - resting membrane potential	R-HSA-5576886	3.145611e-01	0.502
Cation-coupled Chloride cotransporters	R-HSA-426117	4.132563e-01	0.384
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	4.608371e-01	0.336
Co-stimulation by ICOS	R-HSA-9927354	4.608371e-01	0.336
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	2.803131e-01	0.552
Platelet Adhesion to exposed collagen	R-HSA-75892	4.316251e-01	0.365
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.316251e-01	0.365
Diseases associated with the TLR signaling cascade	R-HSA-5602358	3.490411e-01	0.457
Diseases of Immune System	R-HSA-5260271	3.490411e-01	0.457
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.375906e-01	0.472
rRNA modification in the nucleus and cytosol	R-HSA-6790901	3.079936e-01	0.511
Prolactin receptor signaling	R-HSA-1170546	4.680997e-01	0.330
Transcriptional regulation by RUNX1	R-HSA-8878171	3.146073e-01	0.502
Signaling by FGFR4 in disease	R-HSA-5655291	4.680997e-01	0.330
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.693817e-01	0.433
Transmission across Chemical Synapses	R-HSA-112315	4.346491e-01	0.362
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.831842e-01	0.548
Suppression of apoptosis	R-HSA-9635465	3.180435e-01	0.498
PECAM1 interactions	R-HSA-210990	3.180435e-01	0.498
STING mediated induction of host immune responses	R-HSA-1834941	4.406454e-01	0.356
Pyroptosis	R-HSA-5620971	3.506689e-01	0.455
Transcriptional regulation of granulopoiesis	R-HSA-9616222	2.919211e-01	0.535
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	4.417474e-01	0.355
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	2.421062e-01	0.616
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	2.814163e-01	0.551
Transcriptional regulation by small RNAs	R-HSA-5578749	3.462646e-01	0.461
mTORC1-mediated signalling	R-HSA-166208	3.635378e-01	0.439
Hemostasis	R-HSA-109582	3.591319e-01	0.445
Signaling by NTRK3 (TRKC)	R-HSA-9034015	3.359259e-01	0.474
Mitochondrial biogenesis	R-HSA-1592230	2.380511e-01	0.623
GPVI-mediated activation cascade	R-HSA-114604	2.673483e-01	0.573
Zygotic genome activation (ZGA)	R-HSA-9819196	3.085008e-01	0.511
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.375906e-01	0.472
Inhibition of membrane repair	R-HSA-9635644	3.458591e-01	0.461
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	2.606537e-01	0.584
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	3.125769e-01	0.505
Syndecan interactions	R-HSA-3000170	3.911907e-01	0.408
The NLRP3 inflammasome	R-HSA-844456	4.406454e-01	0.356
G0 and Early G1	R-HSA-1538133	4.497318e-01	0.347
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	4.741187e-01	0.324
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	2.834096e-01	0.548
Stimuli-sensing channels	R-HSA-2672351	4.336300e-01	0.363
Inositol phosphate metabolism	R-HSA-1483249	3.947665e-01	0.404
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.636728e-01	0.439
Maturation of nucleoprotein	R-HSA-9694631	2.548325e-01	0.594
Malate-aspartate shuttle	R-HSA-9856872	4.680997e-01	0.330
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	4.741187e-01	0.324
Signaling by Leptin	R-HSA-2586552	2.798358e-01	0.553
Co-inhibition by BTLA	R-HSA-9927353	2.606537e-01	0.584
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.321668e-01	0.364
Displacement of DNA glycosylase by APEX1	R-HSA-110357	4.132563e-01	0.384
MECP2 regulates transcription factors	R-HSA-9022707	4.132563e-01	0.384
Regulation of PTEN localization	R-HSA-8948747	4.132563e-01	0.384
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.437770e-01	0.613
Sodium/Proton exchangers	R-HSA-425986	4.608371e-01	0.336
IRE1alpha activates chaperones	R-HSA-381070	2.690077e-01	0.570
P2Y receptors	R-HSA-417957	4.680997e-01	0.330
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.606537e-01	0.584
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.125769e-01	0.505
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	3.180435e-01	0.498
Uptake and function of diphtheria toxin	R-HSA-5336415	4.132563e-01	0.384
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.608371e-01	0.336
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.571276e-01	0.447
Metal ion SLC transporters	R-HSA-425410	3.965475e-01	0.402
XBP1(S) activates chaperone genes	R-HSA-381038	2.760372e-01	0.559
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	3.635378e-01	0.439
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	4.094487e-01	0.388
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.753502e-01	0.323
Immune System	R-HSA-168256	4.889866e-01	0.311
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.938357e-01	0.306
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.947679e-01	0.306
Regulation of PTEN stability and activity	R-HSA-8948751	4.947679e-01	0.306
Condensation of Prophase Chromosomes	R-HSA-2299718	4.957869e-01	0.305
Glucagon signaling in metabolic regulation	R-HSA-163359	4.981856e-01	0.303
Beta-catenin independent WNT signaling	R-HSA-3858494	4.982433e-01	0.303
Reproduction	R-HSA-1474165	4.990460e-01	0.302
RNA Polymerase II Transcription	R-HSA-73857	4.994601e-01	0.301
Processive synthesis on the C-strand of the telomere	R-HSA-174414	4.996470e-01	0.301
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	4.996470e-01	0.301
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	4.996470e-01	0.301
MyD88 deficiency (TLR2/4)	R-HSA-5602498	5.013754e-01	0.300
Signalling to RAS	R-HSA-167044	5.013754e-01	0.300
Platelet homeostasis	R-HSA-418346	5.026887e-01	0.299
SHC1 events in EGFR signaling	R-HSA-180336	5.034875e-01	0.298
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.034875e-01	0.298
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.034875e-01	0.298
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.034875e-01	0.298
FGFR3 ligand binding and activation	R-HSA-190239	5.034875e-01	0.298
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.034875e-01	0.298
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.034875e-01	0.298
Biotin transport and metabolism	R-HSA-196780	5.034875e-01	0.298
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	5.034875e-01	0.298
Interleukin-21 signaling	R-HSA-9020958	5.060809e-01	0.296
Gap junction degradation	R-HSA-190873	5.060809e-01	0.296
Defects in biotin (Btn) metabolism	R-HSA-3323169	5.060809e-01	0.296
mRNA Editing	R-HSA-75072	5.060809e-01	0.296
Unwinding of DNA	R-HSA-176974	5.060809e-01	0.296
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	5.060809e-01	0.296
Respiratory syncytial virus genome replication	R-HSA-9834752	5.060809e-01	0.296
Interleukin-1 processing	R-HSA-448706	5.060809e-01	0.296
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	5.070914e-01	0.295
Axonal growth stimulation	R-HSA-209563	5.070914e-01	0.295
MET activates PTPN11	R-HSA-8865999	5.070914e-01	0.295
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.070914e-01	0.295
Defective CYP1B1 causes Glaucoma	R-HSA-5579000	5.070914e-01	0.295
Defective ABCA1 causes TGD	R-HSA-5682113	5.070914e-01	0.295
Defective GCLC causes HAGGSD	R-HSA-5578999	5.070914e-01	0.295
Invadopodia formation	R-HSA-8941237	5.070914e-01	0.295
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.070914e-01	0.295
Defective CYP7B1 causes SPG5A and CBAS3	R-HSA-5579013	5.070914e-01	0.295
Defective MAOA causes BRUNS	R-HSA-5579012	5.070914e-01	0.295
STAT6-mediated induction of chemokines	R-HSA-3249367	5.070914e-01	0.295
MET interacts with TNS proteins	R-HSA-8875513	5.070914e-01	0.295
Activation of BMF and translocation to mitochondria	R-HSA-139910	5.070914e-01	0.295
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.070914e-01	0.295
Histamine receptors	R-HSA-390650	5.070914e-01	0.295
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	5.103249e-01	0.292
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	5.104232e-01	0.292
Adipogenesis	R-HSA-9843745	5.115099e-01	0.291
Regulation of RUNX2 expression and activity	R-HSA-8939902	5.120489e-01	0.291
Viral Messenger RNA Synthesis	R-HSA-168325	5.120489e-01	0.291
Translation initiation complex formation	R-HSA-72649	5.139870e-01	0.289
Interleukin-1 signaling	R-HSA-9020702	5.180006e-01	0.286
Extra-nuclear estrogen signaling	R-HSA-9009391	5.180006e-01	0.286
Cellular response to starvation	R-HSA-9711097	5.188460e-01	0.285
HIV Infection	R-HSA-162906	5.190461e-01	0.285
KEAP1-NFE2L2 pathway	R-HSA-9755511	5.200175e-01	0.284
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	5.218604e-01	0.282
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.218604e-01	0.282
Gene expression (Transcription)	R-HSA-74160	5.225643e-01	0.282
Co-inhibition by PD-1	R-HSA-389948	5.229881e-01	0.282
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	5.256768e-01	0.279
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	5.256768e-01	0.279
Telomere Extension By Telomerase	R-HSA-171319	5.256768e-01	0.279
Class I MHC mediated antigen processing & presentation	R-HSA-983169	5.263743e-01	0.279
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	5.302742e-01	0.275
SHC-mediated cascade:FGFR4	R-HSA-5654719	5.306440e-01	0.275
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	5.306440e-01	0.275
Mitochondrial calcium ion transport	R-HSA-8949215	5.306440e-01	0.275
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	5.362254e-01	0.271
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	5.363260e-01	0.271
SARS-CoV Infections	R-HSA-9679506	5.373039e-01	0.270
Regulation of NF-kappa B signaling	R-HSA-9758274	5.376199e-01	0.270
Activation of SMO	R-HSA-5635838	5.376199e-01	0.270
Platelet degranulation	R-HSA-114608	5.379631e-01	0.269
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	5.388318e-01	0.269
Adaptive Immune System	R-HSA-1280218	5.435850e-01	0.265
Oncogene Induced Senescence	R-HSA-2559585	5.450783e-01	0.264
G1/S DNA Damage Checkpoints	R-HSA-69615	5.478461e-01	0.261
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.487759e-01	0.261
2-LTR circle formation	R-HSA-164843	5.487759e-01	0.261
Metabolism of serotonin	R-HSA-380612	5.487759e-01	0.261
PI3K/AKT activation	R-HSA-198203	5.487759e-01	0.261
Arachidonate production from DAG	R-HSA-426048	5.487759e-01	0.261
Interleukin-27 signaling	R-HSA-9020956	5.487759e-01	0.261
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	5.487759e-01	0.261
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	5.487759e-01	0.261
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	5.487759e-01	0.261
Defective factor IX causes hemophilia B	R-HSA-9668250	5.487759e-01	0.261
MAPK3 (ERK1) activation	R-HSA-110056	5.487759e-01	0.261
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	5.487759e-01	0.261
DNA methylation	R-HSA-5334118	5.510950e-01	0.259
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.510950e-01	0.259
Signaling by Erythropoietin	R-HSA-9006335	5.510950e-01	0.259
Ribosomal scanning and start codon recognition	R-HSA-72702	5.516783e-01	0.258
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.516783e-01	0.258
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	5.516783e-01	0.258
MAPK6/MAPK4 signaling	R-HSA-5687128	5.543219e-01	0.256
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	5.561237e-01	0.255
p53-Dependent G1 DNA Damage Response	R-HSA-69563	5.561237e-01	0.255
ER to Golgi Anterograde Transport	R-HSA-199977	5.563806e-01	0.255
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.590388e-01	0.253
PI-3K cascade:FGFR1	R-HSA-5654689	5.590388e-01	0.253
FGFR2 alternative splicing	R-HSA-6803529	5.590388e-01	0.253
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	5.590388e-01	0.253
RAF-independent MAPK1/3 activation	R-HSA-112409	5.590388e-01	0.253
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.590388e-01	0.253
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	5.590388e-01	0.253
Signaling by KIT in disease	R-HSA-9669938	5.590388e-01	0.253
Transcriptional regulation by RUNX3	R-HSA-8878159	5.629853e-01	0.250
Influenza Viral RNA Transcription and Replication	R-HSA-168273	5.657606e-01	0.247
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	5.661473e-01	0.247
PRC2 methylates histones and DNA	R-HSA-212300	5.677821e-01	0.246
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.703683e-01	0.244
Acetylcholine regulates insulin secretion	R-HSA-399997	5.703683e-01	0.244
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	5.703683e-01	0.244
Disorders of Developmental Biology	R-HSA-9675151	5.703683e-01	0.244
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	5.703683e-01	0.244
TNFR1-mediated ceramide production	R-HSA-5626978	5.721335e-01	0.243
NADE modulates death signalling	R-HSA-205025	5.721335e-01	0.243
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	5.721335e-01	0.243
ATP sensitive Potassium channels	R-HSA-1296025	5.721335e-01	0.243
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	5.721335e-01	0.243
Signaling by MAP2K mutants	R-HSA-9652169	5.721335e-01	0.243
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	5.721335e-01	0.243
Regulation of gap junction activity	R-HSA-191650	5.721335e-01	0.243
Transmission across Electrical Synapses	R-HSA-112307	5.721335e-01	0.243
Alanine metabolism	R-HSA-8964540	5.721335e-01	0.243
Electric Transmission Across Gap Junctions	R-HSA-112303	5.721335e-01	0.243
MDK and PTN in ALK signaling	R-HSA-9851151	5.721335e-01	0.243
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	5.721335e-01	0.243
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.721335e-01	0.243
Interleukin-38 signaling	R-HSA-9007892	5.721335e-01	0.243
DAP12 signaling	R-HSA-2424491	5.758322e-01	0.240
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	5.758322e-01	0.240
Late Phase of HIV Life Cycle	R-HSA-162599	5.818526e-01	0.235
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.847091e-01	0.233
Interleukin-20 family signaling	R-HSA-8854691	5.864767e-01	0.232
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.864767e-01	0.232
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.864767e-01	0.232
Formation of the ureteric bud	R-HSA-9830674	5.864767e-01	0.232
HIV Life Cycle	R-HSA-162587	5.880881e-01	0.231
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	5.881507e-01	0.231
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.888070e-01	0.230
CD163 mediating an anti-inflammatory response	R-HSA-9662834	5.888070e-01	0.230
Interleukin-2 signaling	R-HSA-9020558	5.888070e-01	0.230
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	5.888070e-01	0.230
Synthesis of PI	R-HSA-1483226	5.888070e-01	0.230
Chylomicron assembly	R-HSA-8963888	5.888070e-01	0.230
Potential therapeutics for SARS	R-HSA-9679191	5.906665e-01	0.229
MITF-M-dependent gene expression	R-HSA-9856651	5.906665e-01	0.229
MITF-M-regulated melanocyte development	R-HSA-9730414	5.907784e-01	0.229
Budding and maturation of HIV virion	R-HSA-162588	5.998303e-01	0.222
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.016391e-01	0.221
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.016391e-01	0.221
Influenza Infection	R-HSA-168255	6.019266e-01	0.220
Extension of Telomeres	R-HSA-180786	6.058568e-01	0.218
Deadenylation-dependent mRNA decay	R-HSA-429914	6.058568e-01	0.218
Triglyceride metabolism	R-HSA-8979227	6.058568e-01	0.218
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	6.093136e-01	0.215
Mitochondrial protein degradation	R-HSA-9837999	6.093136e-01	0.215
Deadenylation of mRNA	R-HSA-429947	6.128917e-01	0.213
SHC-mediated cascade:FGFR1	R-HSA-5654688	6.128917e-01	0.213
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.128917e-01	0.213
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	6.128917e-01	0.213
Complex III assembly	R-HSA-9865881	6.128917e-01	0.213
mRNA 3'-end processing	R-HSA-72187	6.131903e-01	0.212
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	6.140113e-01	0.212
Gene Silencing by RNA	R-HSA-211000	6.140113e-01	0.212
Peptide chain elongation	R-HSA-156902	6.141889e-01	0.212
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	6.218561e-01	0.206
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	6.218561e-01	0.206
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	6.230413e-01	0.205
ERKs are inactivated	R-HSA-202670	6.261339e-01	0.203
Sensing of DNA Double Strand Breaks	R-HSA-5693548	6.261339e-01	0.203
Integration of provirus	R-HSA-162592	6.261339e-01	0.203
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	6.285963e-01	0.202
Defective CYP17A1 causes AH5	R-HSA-5579028	6.285963e-01	0.202
IRS activation	R-HSA-74713	6.285963e-01	0.202
NOSIP mediated eNOS trafficking	R-HSA-203754	6.285963e-01	0.202
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	6.285963e-01	0.202
FLT3 signaling by CBL mutants	R-HSA-9706377	6.285963e-01	0.202
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	6.285963e-01	0.202
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	6.285963e-01	0.202
PTK6 Down-Regulation	R-HSA-8849472	6.285963e-01	0.202
Activation of AKT2	R-HSA-165158	6.285963e-01	0.202
Activation of C3 and C5	R-HSA-174577	6.285963e-01	0.202
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	6.285963e-01	0.202
Muscarinic acetylcholine receptors	R-HSA-390648	6.285963e-01	0.202
Inositol transporters	R-HSA-429593	6.285963e-01	0.202
NrCAM interactions	R-HSA-447038	6.285963e-01	0.202
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	6.285963e-01	0.202
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	6.285963e-01	0.202
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.313695e-01	0.200
Depolymerization of the Nuclear Lamina	R-HSA-4419969	6.313695e-01	0.200
GAB1 signalosome	R-HSA-180292	6.313695e-01	0.200
Nucleotide-like (purinergic) receptors	R-HSA-418038	6.313695e-01	0.200
Formation of a pool of free 40S subunits	R-HSA-72689	6.369556e-01	0.196
FRS-mediated FGFR1 signaling	R-HSA-5654693	6.382342e-01	0.195
PI-3K cascade:FGFR2	R-HSA-5654695	6.382342e-01	0.195
Glycogen breakdown (glycogenolysis)	R-HSA-70221	6.382342e-01	0.195
Formation of the nephric duct	R-HSA-9830364	6.382342e-01	0.195
RNA Polymerase II Transcription Termination	R-HSA-73856	6.400873e-01	0.194
PPARA activates gene expression	R-HSA-1989781	6.453414e-01	0.190
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.454269e-01	0.190
Assembly of the ORC complex at the origin of replication	R-HSA-68616	6.454269e-01	0.190
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	6.490046e-01	0.188
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.525553e-01	0.185
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	6.525553e-01	0.185
Nuclear signaling by ERBB4	R-HSA-1251985	6.525553e-01	0.185
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	6.564447e-01	0.183
Signaling by PDGF	R-HSA-186797	6.565717e-01	0.183
tRNA processing in the nucleus	R-HSA-6784531	6.565717e-01	0.183
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	6.594855e-01	0.181
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	6.594855e-01	0.181
Regulation of signaling by CBL	R-HSA-912631	6.595235e-01	0.181
Translesion Synthesis by POLH	R-HSA-110320	6.595235e-01	0.181
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.595235e-01	0.181
Diseases of hemostasis	R-HSA-9671793	6.595235e-01	0.181
Other interleukin signaling	R-HSA-449836	6.595235e-01	0.181
RUNX3 regulates p14-ARF	R-HSA-8951936	6.607732e-01	0.180
IRAK1 recruits IKK complex	R-HSA-937039	6.607732e-01	0.180
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	6.607732e-01	0.180
GRB2 events in EGFR signaling	R-HSA-179812	6.607732e-01	0.180
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	6.607732e-01	0.180
RUNX3 regulates NOTCH signaling	R-HSA-8941856	6.607732e-01	0.180
Interleukin-35 Signalling	R-HSA-8984722	6.607732e-01	0.180
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	6.607732e-01	0.180
VLDLR internalisation and degradation	R-HSA-8866427	6.607732e-01	0.180
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	6.607732e-01	0.180
Pervasive developmental disorders	R-HSA-9005895	6.607732e-01	0.180
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.607732e-01	0.180
Disorders of Nervous System Development	R-HSA-9697154	6.607732e-01	0.180
Metalloprotease DUBs	R-HSA-5689901	6.624692e-01	0.179
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	6.624692e-01	0.179
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	6.624692e-01	0.179
HDACs deacetylate histones	R-HSA-3214815	6.661742e-01	0.176
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	6.661898e-01	0.176
Effects of PIP2 hydrolysis	R-HSA-114508	6.669582e-01	0.176
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.669582e-01	0.176
Integration of energy metabolism	R-HSA-163685	6.681495e-01	0.175
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.720721e-01	0.173
Gluconeogenesis	R-HSA-70263	6.774235e-01	0.169
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.776108e-01	0.169
Noncanonical activation of NOTCH3	R-HSA-9017802	6.776108e-01	0.169
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.776108e-01	0.169
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.776108e-01	0.169
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.776108e-01	0.169
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.776108e-01	0.169
Signaling by MAPK mutants	R-HSA-9652817	6.776108e-01	0.169
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.776108e-01	0.169
Pentose phosphate pathway disease	R-HSA-6791465	6.776108e-01	0.169
Ceramide signalling	R-HSA-193681	6.776108e-01	0.169
CDC6 association with the ORC:origin complex	R-HSA-68689	6.776108e-01	0.169
Phosphorylation of Emi1	R-HSA-176417	6.776108e-01	0.169
Formation of the Editosome	R-HSA-75094	6.776108e-01	0.169
Signalling to p38 via RIT and RIN	R-HSA-187706	6.776108e-01	0.169
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.776108e-01	0.169
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.776108e-01	0.169
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	6.776108e-01	0.169
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.776108e-01	0.169
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.776108e-01	0.169
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	6.776108e-01	0.169
EPH-Ephrin signaling	R-HSA-2682334	6.831650e-01	0.165
Sensory processing of sound	R-HSA-9659379	6.847728e-01	0.164
SHC-mediated cascade:FGFR2	R-HSA-5654699	6.855748e-01	0.164
Packaging Of Telomere Ends	R-HSA-171306	6.855748e-01	0.164
RNA Polymerase I Transcription Termination	R-HSA-73863	6.855748e-01	0.164
RNA Polymerase I Promoter Opening	R-HSA-73728	6.855748e-01	0.164
Formation of ATP by chemiosmotic coupling	R-HSA-163210	6.860880e-01	0.164
Formation of definitive endoderm	R-HSA-9823730	6.860880e-01	0.164
Signal transduction by L1	R-HSA-445144	6.860880e-01	0.164
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	6.876145e-01	0.163
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	6.876145e-01	0.163
Ion transport by P-type ATPases	R-HSA-936837	6.881988e-01	0.162
Degradation of GLI2 by the proteasome	R-HSA-5610783	6.908738e-01	0.161
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.908738e-01	0.161
Degradation of GLI1 by the proteasome	R-HSA-5610780	6.908738e-01	0.161
Chylomicron remodeling	R-HSA-8963901	6.927839e-01	0.159
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	6.927839e-01	0.159
Formation of axial mesoderm	R-HSA-9796292	6.927839e-01	0.159
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	6.927839e-01	0.159
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	6.927839e-01	0.159
FGFR1c ligand binding and activation	R-HSA-190373	6.927839e-01	0.159
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	6.927839e-01	0.159
Membrane binding and targetting of GAG proteins	R-HSA-174490	6.927839e-01	0.159
Processing of SMDT1	R-HSA-8949664	6.927839e-01	0.159
PI5P Regulates TP53 Acetylation	R-HSA-6811555	6.927839e-01	0.159
DNA Damage Bypass	R-HSA-73893	6.947555e-01	0.158
SARS-CoV-1-host interactions	R-HSA-9692914	6.947789e-01	0.158
Assembly of the pre-replicative complex	R-HSA-68867	6.960613e-01	0.157
FRS-mediated FGFR2 signaling	R-HSA-5654700	7.075410e-01	0.150
Inflammasomes	R-HSA-622312	7.075410e-01	0.150
Switching of origins to a post-replicative state	R-HSA-69052	7.077369e-01	0.150
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.110691e-01	0.148
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	7.110691e-01	0.148
Nuclear events mediated by NFE2L2	R-HSA-9759194	7.164448e-01	0.145
Chylomicron clearance	R-HSA-8964026	7.201593e-01	0.143
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	7.201593e-01	0.143
Autointegration results in viral DNA circles	R-HSA-177539	7.201593e-01	0.143
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	7.201593e-01	0.143
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	7.201593e-01	0.143
Hydrolysis of LPE	R-HSA-1483152	7.201593e-01	0.143
Neurofascin interactions	R-HSA-447043	7.201593e-01	0.143
Integration of viral DNA into host genomic DNA	R-HSA-175567	7.201593e-01	0.143
Defective factor VIII causes hemophilia A	R-HSA-9662001	7.201593e-01	0.143
HDL clearance	R-HSA-8964011	7.201593e-01	0.143
Nef and signal transduction	R-HSA-164944	7.201593e-01	0.143
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	7.208907e-01	0.142
Retrograde neurotrophin signalling	R-HSA-177504	7.222566e-01	0.141
NRIF signals cell death from the nucleus	R-HSA-205043	7.222566e-01	0.141
cGMP effects	R-HSA-418457	7.222566e-01	0.141
FGFR3c ligand binding and activation	R-HSA-190372	7.222566e-01	0.141
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	7.222566e-01	0.141
Zinc transporters	R-HSA-435354	7.222566e-01	0.141
Signal regulatory protein family interactions	R-HSA-391160	7.222566e-01	0.141
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.226701e-01	0.141
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	7.262576e-01	0.139
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	7.283680e-01	0.138
Termination of translesion DNA synthesis	R-HSA-5656169	7.283680e-01	0.138
Regulation of gene expression in beta cells	R-HSA-210745	7.283680e-01	0.138
DNA Replication Pre-Initiation	R-HSA-69002	7.293606e-01	0.137
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	7.328131e-01	0.135
Eukaryotic Translation Termination	R-HSA-72764	7.328131e-01	0.135
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	7.344885e-01	0.134
EPHB-mediated forward signaling	R-HSA-3928662	7.428880e-01	0.129
RNA Polymerase I Promoter Escape	R-HSA-73772	7.430225e-01	0.129
Formation of RNA Pol II elongation complex	R-HSA-112382	7.430225e-01	0.129
SIRT1 negatively regulates rRNA expression	R-HSA-427359	7.442388e-01	0.128
Cleavage of the damaged purine	R-HSA-110331	7.442388e-01	0.128
UCH proteinases	R-HSA-5689603	7.479150e-01	0.126
Neurotransmitter clearance	R-HSA-112311	7.480650e-01	0.126
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	7.480650e-01	0.126
Translesion synthesis by REV1	R-HSA-110312	7.493035e-01	0.125
Erythropoietin activates RAS	R-HSA-9027284	7.493035e-01	0.125
Telomere C-strand synthesis initiation	R-HSA-174430	7.493035e-01	0.125
Protein methylation	R-HSA-8876725	7.493035e-01	0.125
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	7.493035e-01	0.125
Pre-NOTCH Transcription and Translation	R-HSA-1912408	7.529195e-01	0.123
Telomere Maintenance	R-HSA-157579	7.556544e-01	0.122
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	7.563814e-01	0.121
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.563814e-01	0.121
LDL clearance	R-HSA-8964038	7.563814e-01	0.121
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	7.570945e-01	0.121
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	7.570945e-01	0.121
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.570945e-01	0.121
FGFR3b ligand binding and activation	R-HSA-190371	7.570945e-01	0.121
Disinhibition of SNARE formation	R-HSA-114516	7.570945e-01	0.121
mRNA Editing: C to U Conversion	R-HSA-72200	7.570945e-01	0.121
Nef Mediated CD4 Down-regulation	R-HSA-167590	7.570945e-01	0.121
MET activates PI3K/AKT signaling	R-HSA-8851907	7.570945e-01	0.121
VLDL clearance	R-HSA-8964046	7.570945e-01	0.121
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	7.570945e-01	0.121
Ca2+ activated K+ channels	R-HSA-1296052	7.570945e-01	0.121
Phase 3 - rapid repolarisation	R-HSA-5576890	7.570945e-01	0.121
CHL1 interactions	R-HSA-447041	7.570945e-01	0.121
Maturation of replicase proteins	R-HSA-9694301	7.570945e-01	0.121
Signaling by NOTCH	R-HSA-157118	7.575406e-01	0.121
RNA Polymerase II Transcription Elongation	R-HSA-75955	7.578552e-01	0.120
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	7.578552e-01	0.120
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	7.578552e-01	0.120
Collagen degradation	R-HSA-1442490	7.580513e-01	0.120
Aquaporin-mediated transport	R-HSA-445717	7.580513e-01	0.120
HCMV Early Events	R-HSA-9609690	7.580988e-01	0.120
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	7.584790e-01	0.120
Activation of HOX genes during differentiation	R-HSA-5619507	7.584790e-01	0.120
Fanconi Anemia Pathway	R-HSA-6783310	7.587526e-01	0.120
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	7.589862e-01	0.120
Depurination	R-HSA-73927	7.613326e-01	0.118
MET promotes cell motility	R-HSA-8875878	7.613326e-01	0.118
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.613326e-01	0.118
Ion channel transport	R-HSA-983712	7.624335e-01	0.118
Cell-Cell communication	R-HSA-1500931	7.663922e-01	0.116
Regulation of insulin secretion	R-HSA-422356	7.665691e-01	0.115
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.714543e-01	0.113
RNA Polymerase I Transcription	R-HSA-73864	7.725136e-01	0.112
mRNA Splicing - Minor Pathway	R-HSA-72165	7.738857e-01	0.111
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.738857e-01	0.111
Translesion synthesis by POLI	R-HSA-5656121	7.740515e-01	0.111
Killing mechanisms	R-HSA-9664420	7.740515e-01	0.111
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	7.740515e-01	0.111
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	7.740515e-01	0.111
Differentiation of T cells	R-HSA-9945266	7.740515e-01	0.111
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	7.740515e-01	0.111
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.740515e-01	0.111
Serotonin and melatonin biosynthesis	R-HSA-209931	7.740515e-01	0.111
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	7.753408e-01	0.111
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.767928e-01	0.110
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.767928e-01	0.110
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	7.775497e-01	0.109
Transcriptional Regulation by E2F6	R-HSA-8953750	7.775497e-01	0.109
Plasma lipoprotein clearance	R-HSA-8964043	7.775497e-01	0.109
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	7.839015e-01	0.106
Regulation of mitotic cell cycle	R-HSA-453276	7.839015e-01	0.106
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	7.839015e-01	0.106
NoRC negatively regulates rRNA expression	R-HSA-427413	7.839015e-01	0.106
Inwardly rectifying K+ channels	R-HSA-1296065	7.841426e-01	0.106
DNA strand elongation	R-HSA-69190	7.841426e-01	0.106
Signaling by NOTCH3	R-HSA-9012852	7.856440e-01	0.105
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.891565e-01	0.103
MET receptor recycling	R-HSA-8875656	7.891565e-01	0.103
Formation of annular gap junctions	R-HSA-196025	7.891565e-01	0.103
Activated NTRK2 signals through PI3K	R-HSA-9028335	7.891565e-01	0.103
Regulation of NPAS4 mRNA translation	R-HSA-9768778	7.891565e-01	0.103
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	7.891565e-01	0.103
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.891565e-01	0.103
Axonal growth inhibition (RHOA activation)	R-HSA-193634	7.891565e-01	0.103
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.891565e-01	0.103
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.891565e-01	0.103
Fructose biosynthesis	R-HSA-5652227	7.891565e-01	0.103
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	7.891565e-01	0.103
Downregulation of ERBB4 signaling	R-HSA-1253288	7.891565e-01	0.103
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	7.891565e-01	0.103
phospho-PLA2 pathway	R-HSA-111995	7.891565e-01	0.103
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	7.891565e-01	0.103
TGFBR3 PTM regulation	R-HSA-9839383	7.891565e-01	0.103
Nucleotide salvage defects	R-HSA-9734207	7.891565e-01	0.103
Alpha-defensins	R-HSA-1462054	7.891565e-01	0.103
Chromosome Maintenance	R-HSA-73886	7.925933e-01	0.101
HIV Transcription Elongation	R-HSA-167169	7.929054e-01	0.101
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	7.929054e-01	0.101
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	7.929054e-01	0.101
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.929054e-01	0.101
Glycogen metabolism	R-HSA-8982491	7.929054e-01	0.101
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.953611e-01	0.099
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.957760e-01	0.099
SHC1 events in ERBB4 signaling	R-HSA-1250347	7.966360e-01	0.099
Translesion synthesis by POLK	R-HSA-5655862	7.966360e-01	0.099
Formation of xylulose-5-phosphate	R-HSA-5661270	7.966360e-01	0.099
Galactose catabolism	R-HSA-70370	7.966360e-01	0.099
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.986123e-01	0.098
rRNA processing	R-HSA-72312	8.059493e-01	0.094
Regulation of endogenous retroelements	R-HSA-9842860	8.068468e-01	0.093
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.074183e-01	0.093
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.074183e-01	0.093
Resolution of Abasic Sites (AP sites)	R-HSA-73933	8.074183e-01	0.093
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.133902e-01	0.090
Regulation of CDH1 Expression and Function	R-HSA-9764265	8.145047e-01	0.089
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	8.145047e-01	0.089
TCR signaling	R-HSA-202403	8.166438e-01	0.088
p75NTR regulates axonogenesis	R-HSA-193697	8.169882e-01	0.088
MASTL Facilitates Mitotic Progression	R-HSA-2465910	8.169882e-01	0.088
Calcineurin activates NFAT	R-HSA-2025928	8.169882e-01	0.088
Enzymatic degradation of Dopamine by monoamine oxidase	R-HSA-379398	8.169882e-01	0.088
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	8.169882e-01	0.088
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	8.169882e-01	0.088
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	8.169882e-01	0.088
Regulation of CDH11 gene transcription	R-HSA-9762293	8.169882e-01	0.088
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	8.169882e-01	0.088
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	8.169882e-01	0.088
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	8.171970e-01	0.088
Uptake and function of anthrax toxins	R-HSA-5210891	8.171970e-01	0.088
Specification of primordial germ cells	R-HSA-9827857	8.171970e-01	0.088
RNA Polymerase II Pre-transcription Events	R-HSA-674695	8.176690e-01	0.087
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.211102e-01	0.086
HIV Transcription Initiation	R-HSA-167161	8.211102e-01	0.086
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.211102e-01	0.086
Intra-Golgi traffic	R-HSA-6811438	8.211102e-01	0.086
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.211102e-01	0.086
CLEC7A (Dectin-1) signaling	R-HSA-5607764	8.250245e-01	0.084
Cytoprotection by HMOX1	R-HSA-9707564	8.264049e-01	0.083
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.279861e-01	0.082
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.279861e-01	0.082
SARS-CoV-1 Infection	R-HSA-9678108	8.283231e-01	0.082
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.296988e-01	0.081
Mitophagy	R-HSA-5205647	8.303920e-01	0.081
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	8.303920e-01	0.081
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.303920e-01	0.081
RNA Polymerase I Transcription Initiation	R-HSA-73762	8.340056e-01	0.079
Cleavage of the damaged pyrimidine	R-HSA-110329	8.340056e-01	0.079
Depyrimidination	R-HSA-73928	8.340056e-01	0.079
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.358751e-01	0.078
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.358751e-01	0.078
FGFR1 ligand binding and activation	R-HSA-190242	8.358751e-01	0.078
Mismatch Repair	R-HSA-5358508	8.358751e-01	0.078
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	8.358751e-01	0.078
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	8.358751e-01	0.078
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.378468e-01	0.077
Cellular response to chemical stress	R-HSA-9711123	8.381771e-01	0.077
Activation of NF-kappaB in B cells	R-HSA-1169091	8.389681e-01	0.076
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	8.411475e-01	0.075
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	8.411475e-01	0.075
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.411475e-01	0.075
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	8.411475e-01	0.075
Formation of intermediate mesoderm	R-HSA-9761174	8.411475e-01	0.075
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	8.411475e-01	0.075
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	8.411475e-01	0.075
Receptor Mediated Mitophagy	R-HSA-8934903	8.411475e-01	0.075
Enzymatic degradation of dopamine by COMT	R-HSA-379397	8.411475e-01	0.075
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.411475e-01	0.075
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.445484e-01	0.073
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	8.447681e-01	0.073
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	8.447681e-01	0.073
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.447681e-01	0.073
Signaling by BMP	R-HSA-201451	8.447681e-01	0.073
EPHA-mediated growth cone collapse	R-HSA-3928663	8.447681e-01	0.073
RNA Polymerase II Promoter Escape	R-HSA-73776	8.461309e-01	0.073
Response of Mtb to phagocytosis	R-HSA-9637690	8.461309e-01	0.073
Orc1 removal from chromatin	R-HSA-68949	8.499789e-01	0.071
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	8.499789e-01	0.071
Signaling by FGFR2 IIIa TM	R-HSA-8851708	8.528089e-01	0.069
Pyrimidine biosynthesis	R-HSA-500753	8.528089e-01	0.069
E2F mediated regulation of DNA replication	R-HSA-113510	8.528089e-01	0.069
HDL remodeling	R-HSA-8964058	8.528089e-01	0.069
PCP/CE pathway	R-HSA-4086400	8.562372e-01	0.067
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.564000e-01	0.067
DAP12 interactions	R-HSA-2172127	8.575140e-01	0.067
Phospholipid metabolism	R-HSA-1483257	8.583506e-01	0.066
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.586658e-01	0.066
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	8.586658e-01	0.066
Formation of the Early Elongation Complex	R-HSA-113418	8.586658e-01	0.066
HIV elongation arrest and recovery	R-HSA-167287	8.586658e-01	0.066
Pausing and recovery of HIV elongation	R-HSA-167290	8.586658e-01	0.066
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.596285e-01	0.066
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	8.599574e-01	0.066
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.603665e-01	0.065
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	8.621187e-01	0.064
FGFR2b ligand binding and activation	R-HSA-190377	8.621187e-01	0.064
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.621187e-01	0.064
vRNA Synthesis	R-HSA-192814	8.621187e-01	0.064
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.621187e-01	0.064
vRNP Assembly	R-HSA-192905	8.621187e-01	0.064
Bicarbonate transporters	R-HSA-425381	8.621187e-01	0.064
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	8.621187e-01	0.064
Transport of RCbl within the body	R-HSA-9758890	8.621187e-01	0.064
Dissolution of Fibrin Clot	R-HSA-75205	8.621187e-01	0.064
HCMV Infection	R-HSA-9609646	8.641648e-01	0.063
Selenocysteine synthesis	R-HSA-2408557	8.659590e-01	0.063
Collagen chain trimerization	R-HSA-8948216	8.680786e-01	0.061
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	8.681335e-01	0.061
Glycogen synthesis	R-HSA-3322077	8.681335e-01	0.061
VxPx cargo-targeting to cilium	R-HSA-5620916	8.681335e-01	0.061
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.681335e-01	0.061
Pregnenolone biosynthesis	R-HSA-196108	8.681335e-01	0.061
Signaling by NODAL	R-HSA-1181150	8.681335e-01	0.061
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.681335e-01	0.061
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.681843e-01	0.061
Nucleosome assembly	R-HSA-774815	8.681843e-01	0.061
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	8.681843e-01	0.061
Hedgehog 'on' state	R-HSA-5632684	8.684164e-01	0.061
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.701525e-01	0.060
mRNA Capping	R-HSA-72086	8.714599e-01	0.060
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	8.781716e-01	0.056
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.789307e-01	0.056
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.793596e-01	0.056
Viral mRNA Translation	R-HSA-192823	8.800454e-01	0.055
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.803224e-01	0.055
PI3K events in ERBB4 signaling	R-HSA-1250342	8.803224e-01	0.055
Proton-coupled monocarboxylate transport	R-HSA-433692	8.803224e-01	0.055
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.803224e-01	0.055
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.803224e-01	0.055
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	R-HSA-141333	8.803224e-01	0.055
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	8.803224e-01	0.055
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.803224e-01	0.055
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.803224e-01	0.055
Ribosome-associated quality control	R-HSA-9948299	8.811706e-01	0.055
Lagging Strand Synthesis	R-HSA-69186	8.819785e-01	0.055
Early Phase of HIV Life Cycle	R-HSA-162594	8.819785e-01	0.055
Basigin interactions	R-HSA-210991	8.819785e-01	0.055
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	8.819785e-01	0.055
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.875067e-01	0.052
Synthesis of PC	R-HSA-1483191	8.875067e-01	0.052
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.889993e-01	0.051
Stabilization of p53	R-HSA-69541	8.889993e-01	0.051
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.940074e-01	0.049
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.940074e-01	0.049
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	8.944673e-01	0.048
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	8.944673e-01	0.048
Assembly Of The HIV Virion	R-HSA-175474	8.944673e-01	0.048
Scavenging by Class F Receptors	R-HSA-3000484	8.961237e-01	0.048
Leading Strand Synthesis	R-HSA-69109	8.961237e-01	0.048
Polymerase switching	R-HSA-69091	8.961237e-01	0.048
Proline catabolism	R-HSA-70688	8.961237e-01	0.048
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.961237e-01	0.048
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.961237e-01	0.048
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	8.961237e-01	0.048
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.961237e-01	0.048
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	8.961237e-01	0.048
Estrogen biosynthesis	R-HSA-193144	8.961237e-01	0.048
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.961237e-01	0.048
Pre-NOTCH Expression and Processing	R-HSA-1912422	8.969440e-01	0.047
Protein ubiquitination	R-HSA-8852135	8.991759e-01	0.046
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	9.003512e-01	0.046
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.037396e-01	0.044
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.038923e-01	0.044
Kidney development	R-HSA-9830369	9.043904e-01	0.044
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.057167e-01	0.043
Fructose metabolism	R-HSA-5652084	9.057167e-01	0.043
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.057167e-01	0.043
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.057167e-01	0.043
Ethanol oxidation	R-HSA-71384	9.057167e-01	0.043
Acetylcholine binding and downstream events	R-HSA-181431	9.098395e-01	0.041
Adenylate cyclase activating pathway	R-HSA-170660	9.098395e-01	0.041
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	9.098395e-01	0.041
FGFR2c ligand binding and activation	R-HSA-190375	9.098395e-01	0.041
FGFR4 ligand binding and activation	R-HSA-190322	9.098395e-01	0.041
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	9.098395e-01	0.041
CD28 dependent Vav1 pathway	R-HSA-389359	9.098395e-01	0.041
Mtb iron assimilation by chelation	R-HSA-1222449	9.098395e-01	0.041
Reversible hydration of carbon dioxide	R-HSA-1475029	9.098395e-01	0.041
Diseases of nucleotide metabolism	R-HSA-9735804	9.098395e-01	0.041
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	9.098395e-01	0.041
Synthesis of DNA	R-HSA-69239	9.100780e-01	0.041
Regulation of beta-cell development	R-HSA-186712	9.108641e-01	0.041
Transcription of the HIV genome	R-HSA-167172	9.110861e-01	0.040
Signaling by FGFR2 in disease	R-HSA-5655253	9.119056e-01	0.040
Translation of Structural Proteins	R-HSA-9683701	9.149311e-01	0.039
Organic anion transport by SLCO transporters	R-HSA-879518	9.158362e-01	0.038
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.158362e-01	0.038
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.158362e-01	0.038
GABA receptor activation	R-HSA-977443	9.175267e-01	0.037
RAB geranylgeranylation	R-HSA-8873719	9.175267e-01	0.037
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.211983e-01	0.036
Heme degradation	R-HSA-189483	9.211983e-01	0.036
Miscellaneous transport and binding events	R-HSA-5223345	9.211983e-01	0.036
Removal of the Flap Intermediate	R-HSA-69166	9.217450e-01	0.035
Transport of fatty acids	R-HSA-804914	9.217450e-01	0.035
Synthesis of IPs in the nucleus	R-HSA-1855191	9.217450e-01	0.035
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	9.217450e-01	0.035
Hydrolysis of LPC	R-HSA-1483115	9.217450e-01	0.035
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	9.222885e-01	0.035
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.232745e-01	0.035
Mitochondrial RNA degradation	R-HSA-9836573	9.249280e-01	0.034
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.249280e-01	0.034
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.254695e-01	0.034
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.254695e-01	0.034
Uptake and actions of bacterial toxins	R-HSA-5339562	9.254695e-01	0.034
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.287374e-01	0.032
eNOS activation	R-HSA-203615	9.287374e-01	0.032
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.287374e-01	0.032
G alpha (s) signalling events	R-HSA-418555	9.294433e-01	0.032
Viral Infection Pathways	R-HSA-9824446	9.294450e-01	0.032
NCAM signaling for neurite out-growth	R-HSA-375165	9.295576e-01	0.032
Amino acids regulate mTORC1	R-HSA-9639288	9.315292e-01	0.031
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	9.320789e-01	0.031
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.320789e-01	0.031
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.320789e-01	0.031
G beta:gamma signalling through BTK	R-HSA-8964315	9.320789e-01	0.031
Processive synthesis on the lagging strand	R-HSA-69183	9.320789e-01	0.031
Dopamine clearance from the synaptic cleft	R-HSA-379401	9.320789e-01	0.031
Events associated with phagocytolytic activity of PMN cells	R-HSA-8941413	9.320789e-01	0.031
Lysosphingolipid and LPA receptors	R-HSA-419408	9.320789e-01	0.031
p38MAPK events	R-HSA-171007	9.320789e-01	0.031
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	9.320789e-01	0.031
Other semaphorin interactions	R-HSA-416700	9.320789e-01	0.031
Signaling by Activin	R-HSA-1502540	9.320789e-01	0.031
DNA Damage Reversal	R-HSA-73942	9.320789e-01	0.031
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.330869e-01	0.030
Activation of G protein gated Potassium channels	R-HSA-1296041	9.330869e-01	0.030
Tight junction interactions	R-HSA-420029	9.330869e-01	0.030
G protein gated Potassium channels	R-HSA-1296059	9.330869e-01	0.030
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.330869e-01	0.030
Amyloid fiber formation	R-HSA-977225	9.338202e-01	0.030
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	9.339821e-01	0.030
HCMV Late Events	R-HSA-9610379	9.348010e-01	0.029
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.353108e-01	0.029
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.371447e-01	0.028
Cell junction organization	R-HSA-446728	9.379107e-01	0.028
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.381764e-01	0.028
Downstream TCR signaling	R-HSA-202424	9.386566e-01	0.027
Base Excision Repair	R-HSA-73884	9.386566e-01	0.027
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.404008e-01	0.027
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.404008e-01	0.027
Urea cycle	R-HSA-70635	9.404008e-01	0.027
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.404008e-01	0.027
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	R-HSA-2142816	9.410488e-01	0.026
Defective GALNT3 causes HFTC	R-HSA-5083625	9.410488e-01	0.026
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	9.410488e-01	0.026
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.410488e-01	0.026
Class I peroxisomal membrane protein import	R-HSA-9603798	9.410488e-01	0.026
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.410488e-01	0.026
Regulation of BACH1 activity	R-HSA-9708530	9.410488e-01	0.026
Fructose catabolism	R-HSA-70350	9.410488e-01	0.026
Induction of Cell-Cell Fusion	R-HSA-9733458	9.410488e-01	0.026
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.410488e-01	0.026
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	9.410488e-01	0.026
Attachment and Entry	R-HSA-9678110	9.410488e-01	0.026
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.410498e-01	0.026
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.410498e-01	0.026
Post-translational protein phosphorylation	R-HSA-8957275	9.432443e-01	0.025
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.463207e-01	0.024
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.463207e-01	0.024
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.469505e-01	0.024
Insulin processing	R-HSA-264876	9.469505e-01	0.024
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	9.469505e-01	0.024
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.471506e-01	0.024
Degradation of AXIN	R-HSA-4641257	9.475489e-01	0.023
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.475489e-01	0.023
Degradation of DVL	R-HSA-4641258	9.475489e-01	0.023
Transport to the Golgi and subsequent modification	R-HSA-948021	9.484580e-01	0.023
DNA Replication	R-HSA-69306	9.486622e-01	0.023
G beta:gamma signalling through CDC42	R-HSA-8964616	9.488345e-01	0.023
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.488345e-01	0.023
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.488345e-01	0.023
Heme assimilation	R-HSA-9927020	9.488345e-01	0.023
Transcriptional regulation of testis differentiation	R-HSA-9690406	9.488345e-01	0.023
Passive transport by Aquaporins	R-HSA-432047	9.488345e-01	0.023
tRNA modification in the mitochondrion	R-HSA-6787450	9.488345e-01	0.023
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.511566e-01	0.022
C-type lectin receptors (CLRs)	R-HSA-5621481	9.543485e-01	0.020
Translation of Structural Proteins	R-HSA-9694635	9.551975e-01	0.020
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.555923e-01	0.020
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.555923e-01	0.020
Glycogen storage diseases	R-HSA-3229121	9.555923e-01	0.020
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.555923e-01	0.020
Regulation of FZD by ubiquitination	R-HSA-4641263	9.555923e-01	0.020
Catecholamine biosynthesis	R-HSA-209905	9.555923e-01	0.020
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.580479e-01	0.019
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.580479e-01	0.019
Degradation of CDH1	R-HSA-9766229	9.596475e-01	0.018
G beta:gamma signalling through PLC beta	R-HSA-418217	9.614579e-01	0.017
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.614579e-01	0.017
Activated point mutants of FGFR2	R-HSA-2033519	9.614579e-01	0.017
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	R-HSA-2142670	9.614579e-01	0.017
Synaptic adhesion-like molecules	R-HSA-8849932	9.614579e-01	0.017
Presynaptic function of Kainate receptors	R-HSA-500657	9.614579e-01	0.017
Vitamin D (calciferol) metabolism	R-HSA-196791	9.614579e-01	0.017
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.616488e-01	0.017
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.616488e-01	0.017
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.616488e-01	0.017
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.616488e-01	0.017
Generation of second messenger molecules	R-HSA-202433	9.616488e-01	0.017
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.616488e-01	0.017
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.627257e-01	0.016
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.627257e-01	0.016
Regulation of RAS by GAPs	R-HSA-5658442	9.633601e-01	0.016
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.654961e-01	0.015
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	9.665491e-01	0.015
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.665491e-01	0.015
Amine Oxidase reactions	R-HSA-140179	9.665491e-01	0.015
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.665491e-01	0.015
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.665491e-01	0.015
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.665491e-01	0.015
Adherens junctions interactions	R-HSA-418990	9.668586e-01	0.015
Cargo concentration in the ER	R-HSA-5694530	9.669001e-01	0.015
Aspartate and asparagine metabolism	R-HSA-8963693	9.669001e-01	0.015
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.669890e-01	0.015
Protein localization	R-HSA-9609507	9.689385e-01	0.014
Scavenging by Class A Receptors	R-HSA-3000480	9.689773e-01	0.014
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.689773e-01	0.014
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.695971e-01	0.013
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.709680e-01	0.013
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.709680e-01	0.013
Acyl chain remodelling of PI	R-HSA-1482922	9.709680e-01	0.013
Creatine metabolism	R-HSA-71288	9.709680e-01	0.013
Protein hydroxylation	R-HSA-9629569	9.709680e-01	0.013
Activation of GABAB receptors	R-HSA-991365	9.721243e-01	0.012
GABA B receptor activation	R-HSA-977444	9.721243e-01	0.012
Nucleotide biosynthesis	R-HSA-8956320	9.726783e-01	0.012
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.739390e-01	0.011
ABC-family proteins mediated transport	R-HSA-382556	9.745381e-01	0.011
FGFR2 ligand binding and activation	R-HSA-190241	9.748034e-01	0.011
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.748034e-01	0.011
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.748034e-01	0.011
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.748034e-01	0.011
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.748034e-01	0.011
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.749671e-01	0.011
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.754222e-01	0.011
Cellular response to hypoxia	R-HSA-1234174	9.765809e-01	0.010
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.768604e-01	0.010
Vpu mediated degradation of CD4	R-HSA-180534	9.768924e-01	0.010
Acyl chain remodelling of PC	R-HSA-1482788	9.768924e-01	0.010
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.768924e-01	0.010
Gastrulation	R-HSA-9758941	9.770039e-01	0.010
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.781323e-01	0.010
Androgen biosynthesis	R-HSA-193048	9.781323e-01	0.010
Molybdenum cofactor biosynthesis	R-HSA-947581	9.781323e-01	0.010
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	9.781323e-01	0.010
Serine metabolism	R-HSA-977347	9.781323e-01	0.010
Glutathione synthesis and recycling	R-HSA-174403	9.781323e-01	0.010
Glucocorticoid biosynthesis	R-HSA-194002	9.781323e-01	0.010
Attachment and Entry	R-HSA-9694614	9.781323e-01	0.010
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.785524e-01	0.009
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.795205e-01	0.009
Metabolism of amine-derived hormones	R-HSA-209776	9.797385e-01	0.009
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.798469e-01	0.009
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.798469e-01	0.009
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.810215e-01	0.008
Cellular hexose transport	R-HSA-189200	9.810215e-01	0.008
Regulation of CDH1 Function	R-HSA-9764561	9.816813e-01	0.008
Developmental Cell Lineages	R-HSA-9734767	9.816926e-01	0.008
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.818577e-01	0.008
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.818577e-01	0.008
Acyl chain remodelling of PE	R-HSA-1482839	9.818577e-01	0.008
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.818577e-01	0.008
Integrin cell surface interactions	R-HSA-216083	9.818944e-01	0.008
Pyruvate metabolism	R-HSA-70268	9.819031e-01	0.008
Regulation of pyruvate metabolism	R-HSA-9861718	9.819324e-01	0.008
Regulation of PTEN mRNA translation	R-HSA-8943723	9.835292e-01	0.007
Termination of O-glycan biosynthesis	R-HSA-977068	9.835292e-01	0.007
Free fatty acids regulate insulin secretion	R-HSA-400451	9.835292e-01	0.007
Biosynthesis of maresins	R-HSA-9018682	9.835292e-01	0.007
Carnitine shuttle	R-HSA-200425	9.835292e-01	0.007
Mitochondrial mRNA modification	R-HSA-9937008	9.835292e-01	0.007
ABC transporters in lipid homeostasis	R-HSA-1369062	9.835292e-01	0.007
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.839350e-01	0.007
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.839350e-01	0.007
RNA Polymerase III Transcription	R-HSA-74158	9.839350e-01	0.007
FGFR2 mutant receptor activation	R-HSA-1839126	9.839350e-01	0.007
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.854097e-01	0.006
Plasma lipoprotein remodeling	R-HSA-8963899	9.855008e-01	0.006
CYP2E1 reactions	R-HSA-211999	9.857056e-01	0.006
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.857056e-01	0.006
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	9.857056e-01	0.006
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.857056e-01	0.006
TNFs bind their physiological receptors	R-HSA-5669034	9.857056e-01	0.006
SLC-mediated transport of organic cations	R-HSA-549127	9.857802e-01	0.006
Metabolism of folate and pterines	R-HSA-196757	9.857802e-01	0.006
Cell-cell junction organization	R-HSA-421270	9.860009e-01	0.006
Purine salvage	R-HSA-74217	9.874185e-01	0.005
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.875946e-01	0.005
Acyl chain remodelling of PS	R-HSA-1482801	9.875946e-01	0.005
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.875946e-01	0.005
Laminin interactions	R-HSA-3000157	9.875946e-01	0.005
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.875946e-01	0.005
Formation of paraxial mesoderm	R-HSA-9793380	9.878256e-01	0.005
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.883303e-01	0.005
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.888722e-01	0.005
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.888722e-01	0.005
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.892340e-01	0.005
Suppression of phagosomal maturation	R-HSA-9637687	9.892340e-01	0.005
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.896148e-01	0.005
Hedgehog ligand biogenesis	R-HSA-5358346	9.896148e-01	0.005
Signaling by NOTCH4	R-HSA-9013694	9.901020e-01	0.004
Triglyceride biosynthesis	R-HSA-75109	9.906569e-01	0.004
Synthesis of PE	R-HSA-1483213	9.906569e-01	0.004
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.906569e-01	0.004
Innate Immune System	R-HSA-168249	9.906901e-01	0.004
Citric acid cycle (TCA cycle)	R-HSA-71403	9.910281e-01	0.004
CD22 mediated BCR regulation	R-HSA-5690714	9.910860e-01	0.004
Hh mutants are degraded by ERAD	R-HSA-5362768	9.913045e-01	0.004
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.913045e-01	0.004
Maturation of spike protein	R-HSA-9694548	9.913045e-01	0.004
Developmental Biology	R-HSA-1266738	9.918018e-01	0.004
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.918917e-01	0.004
Insulin receptor recycling	R-HSA-77387	9.918917e-01	0.004
Degradation of CRY and PER proteins	R-HSA-9932298	9.923173e-01	0.003
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.926294e-01	0.003
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.927755e-01	0.003
Thyroxine biosynthesis	R-HSA-209968	9.929635e-01	0.003
Glucagon-type ligand receptors	R-HSA-420092	9.929635e-01	0.003
ABC transporter disorders	R-HSA-5619084	9.933366e-01	0.003
Cholesterol biosynthesis	R-HSA-191273	9.933366e-01	0.003
Metabolism of steroid hormones	R-HSA-196071	9.935005e-01	0.003
Degradation of the extracellular matrix	R-HSA-1474228	9.937047e-01	0.003
Neddylation	R-HSA-8951664	9.938237e-01	0.003
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.938936e-01	0.003
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.939711e-01	0.003
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.940085e-01	0.003
ER-Phagosome pathway	R-HSA-1236974	9.940455e-01	0.003
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.941552e-01	0.003
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.947008e-01	0.002
Molecules associated with elastic fibres	R-HSA-2129379	9.947008e-01	0.002
Proteasome assembly	R-HSA-9907900	9.947114e-01	0.002
Surfactant metabolism	R-HSA-5683826	9.947114e-01	0.002
Amine ligand-binding receptors	R-HSA-375280	9.947114e-01	0.002
COPII-mediated vesicle transport	R-HSA-204005	9.952794e-01	0.002
Asymmetric localization of PCP proteins	R-HSA-4608870	9.953332e-01	0.002
Somitogenesis	R-HSA-9824272	9.953332e-01	0.002
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.954014e-01	0.002
Metabolism of cofactors	R-HSA-8978934	9.957602e-01	0.002
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.958151e-01	0.002
Parasitic Infection Pathways	R-HSA-9824443	9.959203e-01	0.002
Leishmania infection	R-HSA-9658195	9.959203e-01	0.002
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.959768e-01	0.002
Recycling of bile acids and salts	R-HSA-159418	9.960093e-01	0.002
Glutathione conjugation	R-HSA-156590	9.962710e-01	0.002
Signaling by Retinoic Acid	R-HSA-5362517	9.962710e-01	0.002
Collagen formation	R-HSA-1474290	9.966669e-01	0.001
Endogenous sterols	R-HSA-211976	9.966785e-01	0.001
Parasite infection	R-HSA-9664407	9.969656e-01	0.001
Leishmania phagocytosis	R-HSA-9664417	9.969656e-01	0.001
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.969656e-01	0.001
Signal amplification	R-HSA-392518	9.969949e-01	0.001
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.969949e-01	0.001
Signaling by NOTCH2	R-HSA-1980145	9.969949e-01	0.001
RA biosynthesis pathway	R-HSA-5365859	9.969949e-01	0.001
Regulation of Apoptosis	R-HSA-169911	9.973922e-01	0.001
Metabolism of steroids	R-HSA-8957322	9.974372e-01	0.001
tRNA processing	R-HSA-72306	9.975282e-01	0.001
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.976408e-01	0.001
Glycosphingolipid transport	R-HSA-9845576	9.977371e-01	0.001
Antigen processing-Cross presentation	R-HSA-1236975	9.979608e-01	0.001
Selenoamino acid metabolism	R-HSA-2408522	9.980128e-01	0.001
NCAM1 interactions	R-HSA-419037	9.980363e-01	0.001
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.980363e-01	0.001
Synthesis of bile acids and bile salts	R-HSA-192105	9.981603e-01	0.001
Neurotransmitter release cycle	R-HSA-112310	9.982419e-01	0.001
Elastic fibre formation	R-HSA-1566948	9.982960e-01	0.001
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.982960e-01	0.001
Bile acid and bile salt metabolism	R-HSA-194068	9.983176e-01	0.001
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.985214e-01	0.001
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.985214e-01	0.001
Pentose phosphate pathway	R-HSA-71336	9.985214e-01	0.001
O-linked glycosylation of mucins	R-HSA-913709	9.985359e-01	0.001
FCERI mediated MAPK activation	R-HSA-2871796	9.986140e-01	0.001
G alpha (z) signalling events	R-HSA-418597	9.986830e-01	0.001
Paracetamol ADME	R-HSA-9753281	9.986830e-01	0.001
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.988867e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.989660e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.989740e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.989740e-01	0.000
Dectin-2 family	R-HSA-5621480	9.989803e-01	0.000
Synthesis of PA	R-HSA-1483166	9.989803e-01	0.000
Cytosolic tRNA aminoacylation	R-HSA-379716	9.991618e-01	0.000
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.991618e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.991917e-01	0.000
Peroxisomal protein import	R-HSA-9033241	9.992111e-01	0.000
Amino acid transport across the plasma membrane	R-HSA-352230	9.992111e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.992232e-01	0.000
Defensins	R-HSA-1461973	9.992727e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.992828e-01	0.000
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.992828e-01	0.000
SLC transporter disorders	R-HSA-5619102	9.993305e-01	0.000
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.993689e-01	0.000
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.993689e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.993901e-01	0.000
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.995249e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.995288e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.995567e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.995567e-01	0.000
Xenobiotics	R-HSA-211981	9.995860e-01	0.000
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.995877e-01	0.000
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.996896e-01	0.000
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.996896e-01	0.000
Chemokine receptors bind chemokines	R-HSA-380108	9.996896e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.996917e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.996943e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.997019e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.997194e-01	0.000
SLC-mediated transport of amino acids	R-HSA-9958863	9.997194e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.997194e-01	0.000
Azathioprine ADME	R-HSA-9748787	9.997307e-01	0.000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.997307e-01	0.000
The phototransduction cascade	R-HSA-2514856	9.997664e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.997693e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.997907e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.998136e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.998170e-01	0.000
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.998537e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.998636e-01	0.000
Aspirin ADME	R-HSA-9749641	9.998716e-01	0.000
Digestion	R-HSA-8935690	9.998851e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999256e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999340e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.999349e-01	0.000
Metabolism of polyamines	R-HSA-351202	9.999349e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999362e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.999416e-01	0.000
Translation	R-HSA-72766	9.999473e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.999511e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999519e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999519e-01	0.000
Digestion and absorption	R-HSA-8963743	9.999575e-01	0.000
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.999680e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999722e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.999864e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.999864e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.999864e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999880e-01	0.000
Purine catabolism	R-HSA-74259	9.999882e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999910e-01	0.000
Iron uptake and transport	R-HSA-917937	9.999923e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999943e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999959e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999959e-01	0.000
Disease	R-HSA-1643685	9.999960e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999967e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999968e-01	0.000
Infectious disease	R-HSA-5663205	9.999977e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999979e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999979e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999984e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999985e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.999986e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999993e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999993e-01	0.000
Transport of small molecules	R-HSA-382551	9.999993e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999994e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999994e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999996e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999997e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999998e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999998e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999998e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999998e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999998e-01	0.000
Keratinization	R-HSA-6805567	9.999999e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999999e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999999e-01	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Initial triggering of complement	R-HSA-166663	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cellular response to heat stress	R-HSA-3371556	2.220446e-16	15.654
HSF1-dependent transactivation	R-HSA-3371571	1.521006e-14	13.818
Attenuation phase	R-HSA-3371568	9.592327e-14	13.018
M Phase	R-HSA-68886	5.244694e-13	12.280
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	7.728262e-13	12.112
Cell Cycle	R-HSA-1640170	1.068701e-12	11.971
Cellular responses to stress	R-HSA-2262752	1.556755e-12	11.808
Cellular responses to stimuli	R-HSA-8953897	4.727441e-12	11.325
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.671630e-11	10.777
HSF1 activation	R-HSA-3371511	2.537759e-11	10.596
Cell Cycle, Mitotic	R-HSA-69278	4.675937e-11	10.330
Mitotic Prometaphase	R-HSA-68877	2.239398e-10	9.650
Mitotic Anaphase	R-HSA-68882	4.171521e-10	9.380
Mitotic Metaphase and Anaphase	R-HSA-2555396	4.834877e-10	9.316
Signal Transduction	R-HSA-162582	2.258233e-09	8.646
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	5.382308e-09	8.269
Separation of Sister Chromatids	R-HSA-2467813	8.088803e-09	8.092
Membrane Trafficking	R-HSA-199991	1.193192e-08	7.923
Aggrephagy	R-HSA-9646399	2.133831e-08	7.671
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.971740e-08	7.527
Axon guidance	R-HSA-422475	3.358220e-08	7.474
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.949473e-08	7.403
Nervous system development	R-HSA-9675108	4.518359e-08	7.345
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	5.020711e-08	7.299
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	5.020711e-08	7.299
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.221296e-08	7.085
ISG15 antiviral mechanism	R-HSA-1169408	8.001881e-08	7.097
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.063661e-07	6.973
Kinesins	R-HSA-983189	1.179173e-07	6.928
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.342444e-07	6.872
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.628950e-07	6.788
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.684773e-07	6.773
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.938354e-07	6.713
Apoptotic execution phase	R-HSA-75153	1.912694e-07	6.718
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.153702e-07	6.667
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	2.406130e-07	6.619
Transport of connexons to the plasma membrane	R-HSA-190872	2.767301e-07	6.558
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.968209e-07	6.401
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	5.463062e-07	6.263
G2/M Transition	R-HSA-69275	5.350091e-07	6.272
Mitotic G2-G2/M phases	R-HSA-453274	6.856146e-07	6.164
Activation of AMPK downstream of NMDARs	R-HSA-9619483	7.663545e-07	6.116
Signaling downstream of RAS mutants	R-HSA-9649948	8.105395e-07	6.091
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	8.105395e-07	6.091
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	8.105395e-07	6.091
Signaling by RAS mutants	R-HSA-6802949	8.105395e-07	6.091
Signaling by RAF1 mutants	R-HSA-9656223	8.595079e-07	6.066
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	9.032444e-07	6.044
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.013988e-06	5.994
Recycling pathway of L1	R-HSA-437239	1.057133e-06	5.976
Cell Cycle Checkpoints	R-HSA-69620	1.087566e-06	5.964
Selective autophagy	R-HSA-9663891	1.421912e-06	5.847
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.433534e-06	5.844
Autophagy	R-HSA-9612973	2.377543e-06	5.624
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.980873e-06	5.400
Signaling by ROBO receptors	R-HSA-376176	3.898264e-06	5.409
Interleukin-12 signaling	R-HSA-9020591	3.994470e-06	5.399
Post-chaperonin tubulin folding pathway	R-HSA-389977	4.121024e-06	5.385
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	5.361737e-06	5.271
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	6.692991e-06	5.174
Gap junction trafficking and regulation	R-HSA-157858	6.745092e-06	5.171
Gap junction trafficking	R-HSA-190828	7.750420e-06	5.111
PKR-mediated signaling	R-HSA-9833482	8.341073e-06	5.079
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	8.696978e-06	5.061
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.079455e-06	5.042
Chaperone Mediated Autophagy	R-HSA-9613829	1.060421e-05	4.975
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.088722e-05	4.963
Macroautophagy	R-HSA-1632852	1.161507e-05	4.935
Apoptosis	R-HSA-109581	1.190982e-05	4.924
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.322275e-05	4.879
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.346363e-05	4.871
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.346363e-05	4.871
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.614111e-05	4.792
Oncogenic MAPK signaling	R-HSA-6802957	1.960037e-05	4.708
Golgi-to-ER retrograde transport	R-HSA-8856688	1.997056e-05	4.700
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.020920e-05	4.694
Vesicle-mediated transport	R-HSA-5653656	2.455371e-05	4.610
Muscle contraction	R-HSA-397014	2.382596e-05	4.623
Cilium Assembly	R-HSA-5617833	2.413390e-05	4.617
Eukaryotic Translation Elongation	R-HSA-156842	2.859399e-05	4.544
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	2.951341e-05	4.530
Eukaryotic Translation Initiation	R-HSA-72613	3.058061e-05	4.515
Cap-dependent Translation Initiation	R-HSA-72737	3.058061e-05	4.515
Post NMDA receptor activation events	R-HSA-438064	3.168957e-05	4.499
Gap junction assembly	R-HSA-190861	3.000256e-05	4.523
Interleukin-12 family signaling	R-HSA-447115	3.168957e-05	4.499
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.594865e-05	4.444
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.594865e-05	4.444
Influenza Infection	R-HSA-168255	3.740538e-05	4.427
Regulation of PTEN localization	R-HSA-8948747	4.160124e-05	4.381
Cargo trafficking to the periciliary membrane	R-HSA-5620920	4.839445e-05	4.315
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	5.244086e-05	4.280
MAP2K and MAPK activation	R-HSA-5674135	5.390269e-05	4.268
Programmed Cell Death	R-HSA-5357801	5.404915e-05	4.267
AURKA Activation by TPX2	R-HSA-8854518	6.160169e-05	4.210
Death Receptor Signaling	R-HSA-73887	5.894344e-05	4.230
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	6.425130e-05	4.192
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	7.221965e-05	4.141
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	7.506627e-05	4.125
Striated Muscle Contraction	R-HSA-390522	9.256807e-05	4.034
Transcriptional Regulation by E2F6	R-HSA-8953750	1.000477e-04	4.000
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.000477e-04	4.000
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.179456e-04	3.928
Nuclear Envelope Breakdown	R-HSA-2980766	1.181970e-04	3.927
Formation of a pool of free 40S subunits	R-HSA-72689	1.348009e-04	3.870
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.343341e-04	3.872
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	1.278208e-04	3.893
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.336649e-04	3.874
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.447521e-04	3.839
Interferon Signaling	R-HSA-913531	1.455654e-04	3.837
mRNA 3'-end processing	R-HSA-72187	1.491233e-04	3.826
Smooth Muscle Contraction	R-HSA-445355	1.790275e-04	3.747
L1CAM interactions	R-HSA-373760	1.824920e-04	3.739
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.926639e-04	3.715
Josephin domain DUBs	R-HSA-5689877	2.073100e-04	3.683
RNA Polymerase II Transcription Termination	R-HSA-73856	2.350529e-04	3.629
Processing of DNA double-strand break ends	R-HSA-5693607	2.297569e-04	3.639
Mitotic Spindle Checkpoint	R-HSA-69618	2.569974e-04	3.590
Centrosome maturation	R-HSA-380287	2.597652e-04	3.585
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.701090e-04	3.568
Mitotic Prophase	R-HSA-68875	2.875871e-04	3.541
Metabolism of RNA	R-HSA-8953854	2.908601e-04	3.536
TNF signaling	R-HSA-75893	3.021139e-04	3.520
G2/M Checkpoints	R-HSA-69481	3.029802e-04	3.519
ChREBP activates metabolic gene expression	R-HSA-163765	3.225859e-04	3.491
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	3.225859e-04	3.491
COPI-mediated anterograde transport	R-HSA-6807878	3.828337e-04	3.417
p75NTR signals via NF-kB	R-HSA-193639	3.851999e-04	3.414
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	3.851999e-04	3.414
Cell-extracellular matrix interactions	R-HSA-446353	3.851999e-04	3.414
Late endosomal microautophagy	R-HSA-9615710	4.114183e-04	3.386
Interactions of Rev with host cellular proteins	R-HSA-177243	4.281629e-04	3.368
Nuclear import of Rev protein	R-HSA-180746	4.300046e-04	3.367
FLT3 signaling by CBL mutants	R-HSA-9706377	4.777625e-04	3.321
NF-kB is activated and signals survival	R-HSA-209560	4.843611e-04	3.315
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	4.843611e-04	3.315
Amplification of signal from the kinetochores	R-HSA-141424	4.540254e-04	3.343
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.540254e-04	3.343
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.453645e-04	3.351
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	4.843611e-04	3.315
snRNP Assembly	R-HSA-191859	4.923655e-04	3.308
Metabolism of non-coding RNA	R-HSA-194441	4.923655e-04	3.308
Protein folding	R-HSA-391251	5.043640e-04	3.297
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	5.179540e-04	3.286
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.226693e-04	3.282
Chaperonin-mediated protein folding	R-HSA-390466	5.867567e-04	3.232
G2/M DNA damage checkpoint	R-HSA-69473	6.005905e-04	3.221
p75NTR recruits signalling complexes	R-HSA-209543	7.050195e-04	3.152
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	6.466055e-04	3.189
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	6.466055e-04	3.189
Peptide chain elongation	R-HSA-156902	6.648792e-04	3.177
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	6.427650e-04	3.192
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	6.566831e-04	3.183
Signaling by ALK in cancer	R-HSA-9700206	6.566831e-04	3.183
SARS-CoV-2-host interactions	R-HSA-9705683	7.145399e-04	3.146
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	7.239519e-04	3.140
Transcriptional Regulation by TP53	R-HSA-3700989	7.474816e-04	3.126
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	7.484013e-04	3.126
Vpr-mediated nuclear import of PICs	R-HSA-180910	7.892958e-04	3.103
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.184179e-04	3.037
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	9.542370e-04	3.020
IPs transport between nucleus and cytosol	R-HSA-1855170	9.843075e-04	3.007
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.002695e-03	2.999
Organelle biogenesis and maintenance	R-HSA-1852241	1.054661e-03	2.977
Homology Directed Repair	R-HSA-5693538	1.152234e-03	2.938
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.201223e-03	2.920
NRIF signals cell death from the nucleus	R-HSA-205043	1.380646e-03	2.860
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.370744e-03	2.863
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.416913e-03	2.849
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.370744e-03	2.863
Glycolysis	R-HSA-70171	1.419202e-03	2.848
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.494653e-03	2.825
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.541907e-03	2.812
Diseases of programmed cell death	R-HSA-9645723	1.591778e-03	2.798
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.737866e-03	2.760
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.753406e-03	2.756
Translation initiation complex formation	R-HSA-72649	1.791872e-03	2.747
Neurodegenerative Diseases	R-HSA-8863678	1.828092e-03	2.738
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.828092e-03	2.738
Negative regulation of MAPK pathway	R-HSA-5675221	1.927162e-03	2.715
DNA Double-Strand Break Repair	R-HSA-5693532	2.157302e-03	2.666
Negative regulation of MET activity	R-HSA-6807004	2.177020e-03	2.662
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.221730e-03	2.653
Evasion by RSV of host interferon responses	R-HSA-9833109	2.226561e-03	2.652
Cohesin Loading onto Chromatin	R-HSA-2470946	2.283794e-03	2.641
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	2.354626e-03	2.628
Meiosis	R-HSA-1500620	2.357269e-03	2.628
Ribosomal scanning and start codon recognition	R-HSA-72702	2.379621e-03	2.623
HCMV Early Events	R-HSA-9609690	2.539745e-03	2.595
Ovarian tumor domain proteases	R-HSA-5689896	2.496997e-03	2.603
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.601954e-03	2.585
Ion homeostasis	R-HSA-5578775	2.379621e-03	2.623
Cellular Senescence	R-HSA-2559583	2.716619e-03	2.566
Negative regulation of FLT3	R-HSA-9706369	2.479734e-03	2.606
Ion transport by P-type ATPases	R-HSA-936837	2.679198e-03	2.572
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.758870e-03	2.559
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.758870e-03	2.559
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.758870e-03	2.559
p75 NTR receptor-mediated signalling	R-HSA-193704	2.831289e-03	2.548
SARS-CoV-1-host interactions	R-HSA-9692914	2.885159e-03	2.540
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.914135e-03	2.535
Transcriptional regulation by small RNAs	R-HSA-5578749	2.925507e-03	2.534
HIV Life Cycle	R-HSA-162587	2.957750e-03	2.529
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.117890e-03	2.506
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	3.173441e-03	2.498
Regulation of necroptotic cell death	R-HSA-5675482	3.222252e-03	2.492
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.234594e-03	2.490
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	3.234594e-03	2.490
Late Phase of HIV Life Cycle	R-HSA-162599	3.344763e-03	2.476
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.413896e-03	2.467
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.413896e-03	2.467
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	3.413896e-03	2.467
Myoclonic epilepsy of Lafora	R-HSA-3785653	3.420474e-03	2.466
Downregulation of ERBB4 signaling	R-HSA-1253288	3.420474e-03	2.466
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.420474e-03	2.466
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.420474e-03	2.466
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	3.551871e-03	2.450
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	3.611322e-03	2.442
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.838086e-03	2.416
mRNA Splicing - Major Pathway	R-HSA-72163	3.980622e-03	2.400
RAF activation	R-HSA-5673000	4.543501e-03	2.343
Ribosome-associated quality control	R-HSA-9948299	4.334202e-03	2.363
PKMTs methylate histone lysines	R-HSA-3214841	4.743145e-03	2.324
Regulation of TNFR1 signaling	R-HSA-5357905	4.156585e-03	2.381
Membrane binding and targetting of GAG proteins	R-HSA-174490	4.752239e-03	2.323
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.281059e-03	2.368
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	4.156585e-03	2.381
Glucose metabolism	R-HSA-70326	4.550844e-03	2.342
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	4.743145e-03	2.324
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	4.915575e-03	2.308
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	4.915575e-03	2.308
Calcineurin activates NFAT	R-HSA-2025928	4.915575e-03	2.308
ER to Golgi Anterograde Transport	R-HSA-199977	4.925724e-03	2.308
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.993116e-03	2.302
Inositol phosphate metabolism	R-HSA-1483249	5.001509e-03	2.301
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	5.488438e-03	2.261
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.491886e-03	2.260
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	5.732091e-03	2.242
Downregulation of ERBB2 signaling	R-HSA-8863795	5.921469e-03	2.228
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	6.076167e-03	2.216
Maturation of protein E	R-HSA-9694493	6.214336e-03	2.207
Maturation of protein E	R-HSA-9683683	6.214336e-03	2.207
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	6.218190e-03	2.206
DNA Damage Bypass	R-HSA-73893	6.270843e-03	2.203
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	6.349294e-03	2.197
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	6.504361e-03	2.187
Cytokine Signaling in Immune system	R-HSA-1280215	6.529576e-03	2.185
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.566888e-03	2.183
Regulation of TP53 Activity	R-HSA-5633007	6.823259e-03	2.166
Folding of actin by CCT/TriC	R-HSA-390450	6.823550e-03	2.166
Apoptosis induced DNA fragmentation	R-HSA-140342	6.823550e-03	2.166
Pexophagy	R-HSA-9664873	6.823550e-03	2.166
Regulation of CDH1 Function	R-HSA-9764561	6.864822e-03	2.163
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.014014e-03	2.154
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	7.988062e-03	2.098
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	7.988062e-03	2.098
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.732507e-03	2.112
mRNA Splicing	R-HSA-72172	7.994779e-03	2.097
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.437164e-03	2.074
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	7.284703e-03	2.138
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	7.988062e-03	2.098
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.284703e-03	2.138
Spry regulation of FGF signaling	R-HSA-1295596	7.988062e-03	2.098
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	7.394546e-03	2.131
Signaling by ERBB4	R-HSA-1236394	8.436406e-03	2.074
MHC class II antigen presentation	R-HSA-2132295	7.456969e-03	2.127
DNA Repair	R-HSA-73894	8.469810e-03	2.072
HCMV Infection	R-HSA-9609646	8.603134e-03	2.065
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	8.644227e-03	2.063
Eukaryotic Translation Termination	R-HSA-72764	8.644227e-03	2.063
DNA Double Strand Break Response	R-HSA-5693606	9.088023e-03	2.042
HDR through Homologous Recombination (HRR)	R-HSA-5685942	9.088023e-03	2.042
Signaling by EGFR in Cancer	R-HSA-1643713	9.177870e-03	2.037
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	9.196886e-03	2.036
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.322353e-03	2.030
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	9.525897e-03	2.021
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	9.894002e-03	2.005
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.040617e-02	1.983
Gene expression (Transcription)	R-HSA-74160	1.065123e-02	1.973
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.081925e-02	1.966
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.195447e-02	1.922
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.195447e-02	1.922
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.195447e-02	1.922
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.195447e-02	1.922
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.195447e-02	1.922
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.208500e-02	1.918
tRNA processing in the nucleus	R-HSA-6784531	1.209994e-02	1.917
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	1.274310e-02	1.895
Dual Incision in GG-NER	R-HSA-5696400	1.298419e-02	1.887
Hedgehog 'off' state	R-HSA-5610787	1.322947e-02	1.878
Semaphorin interactions	R-HSA-373755	1.344327e-02	1.871
Regulation of endogenous retroelements	R-HSA-9842860	1.552696e-02	1.809
Viral mRNA Translation	R-HSA-192823	1.678672e-02	1.775
Signaling by EGFR	R-HSA-177929	1.449789e-02	1.839
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.506932e-02	1.822
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.395702e-02	1.855
Termination of translesion DNA synthesis	R-HSA-5656169	1.496399e-02	1.825
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.553331e-02	1.809
Regulation of FZD by ubiquitination	R-HSA-4641263	1.543610e-02	1.811
Oncogene Induced Senescence	R-HSA-2559585	1.493712e-02	1.826
Intraflagellar transport	R-HSA-5620924	1.380480e-02	1.860
Regulation of TP53 Degradation	R-HSA-6804757	1.709810e-02	1.767
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	1.374332e-02	1.862
Signaling by Hippo	R-HSA-2028269	1.543610e-02	1.811
rRNA processing	R-HSA-72312	1.400452e-02	1.854
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.430784e-02	1.844
Host Interactions of HIV factors	R-HSA-162909	1.509897e-02	1.821
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	1.553331e-02	1.809
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	1.553331e-02	1.809
Selenocysteine synthesis	R-HSA-2408557	1.434219e-02	1.843
FLT3 signaling in disease	R-HSA-9682385	1.709810e-02	1.767
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.735070e-02	1.761
Formation of annular gap junctions	R-HSA-196025	1.804329e-02	1.744
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.804329e-02	1.744
Modulation by Mtb of host immune system	R-HSA-9637628	1.804329e-02	1.744
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.816576e-02	1.741
TBC/RABGAPs	R-HSA-8854214	1.852317e-02	1.732
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.852317e-02	1.732
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.872989e-02	1.727
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.872989e-02	1.727
Viral Infection Pathways	R-HSA-9824446	1.913792e-02	1.718
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	1.958247e-02	1.708
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.958247e-02	1.708
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.958247e-02	1.708
Protein ubiquitination	R-HSA-8852135	1.988807e-02	1.701
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.997395e-02	1.700
EGFR downregulation	R-HSA-182971	2.006081e-02	1.698
Budding and maturation of HIV virion	R-HSA-162588	2.006081e-02	1.698
Cell-Cell communication	R-HSA-1500931	2.182816e-02	1.661
Clathrin-mediated endocytosis	R-HSA-8856828	2.183308e-02	1.661
RNA Polymerase II Transcription	R-HSA-73857	2.224666e-02	1.653
Regulation of signaling by CBL	R-HSA-912631	2.247367e-02	1.648
IKK complex recruitment mediated by RIP1	R-HSA-937041	2.247367e-02	1.648
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.247367e-02	1.648
Translesion Synthesis by POLH	R-HSA-110320	2.247367e-02	1.648
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.302495e-02	1.638
Long-term potentiation	R-HSA-9620244	2.332449e-02	1.632
HDMs demethylate histones	R-HSA-3214842	2.332449e-02	1.632
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	2.369292e-02	1.625
Gap junction degradation	R-HSA-190873	2.385536e-02	1.622
Meiotic synapsis	R-HSA-1221632	2.395911e-02	1.621
Viral Messenger RNA Synthesis	R-HSA-168325	2.416103e-02	1.617
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.426781e-02	1.615
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.426781e-02	1.615
Ion channel transport	R-HSA-983712	2.450360e-02	1.611
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.494350e-02	1.603
G alpha (12/13) signalling events	R-HSA-416482	2.578714e-02	1.589
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.581831e-02	1.588
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.669054e-02	1.574
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.669054e-02	1.574
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.669054e-02	1.574
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.669054e-02	1.574
Nephrin family interactions	R-HSA-373753	2.669054e-02	1.574
Metalloprotease DUBs	R-HSA-5689901	2.704314e-02	1.568
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	2.704314e-02	1.568
HIV Infection	R-HSA-162906	2.723028e-02	1.565
SARS-CoV Infections	R-HSA-9679506	2.756643e-02	1.560
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.757676e-02	1.559
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.757676e-02	1.559
Nuclear signaling by ERBB4	R-HSA-1251985	2.804880e-02	1.552
Manipulation of host energy metabolism	R-HSA-9636667	3.021540e-02	1.520
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.612573e-02	1.442
MET activates RAP1 and RAC1	R-HSA-8875555	3.068027e-02	1.513
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.068027e-02	1.513
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.662209e-02	1.436
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	3.662209e-02	1.436
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.373747e-02	1.472
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.068027e-02	1.513
Breakdown of the nuclear lamina	R-HSA-352238	3.021540e-02	1.520
Protein methylation	R-HSA-8876725	2.961890e-02	1.528
TCF dependent signaling in response to WNT	R-HSA-201681	2.887254e-02	1.540
RAF/MAP kinase cascade	R-HSA-5673001	3.436715e-02	1.464
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.612573e-02	1.442
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.795342e-02	1.421
NRAGE signals death through JNK	R-HSA-193648	3.219652e-02	1.492
Rab regulation of trafficking	R-HSA-9007101	3.042519e-02	1.517
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.564538e-02	1.448
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.519057e-02	1.454
NOD1/2 Signaling Pathway	R-HSA-168638	3.373747e-02	1.472
Mitophagy	R-HSA-5205647	3.373747e-02	1.472
Platelet degranulation	R-HSA-114608	3.478889e-02	1.459
Cell junction organization	R-HSA-446728	3.237838e-02	1.490
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	3.140087e-02	1.503
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.961890e-02	1.528
Assembly Of The HIV Virion	R-HSA-175474	3.662209e-02	1.436
SARS-CoV-2 Infection	R-HSA-9694516	3.730070e-02	1.428
Nucleotide Excision Repair	R-HSA-5696398	3.838444e-02	1.416
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.854190e-02	1.414
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	4.055510e-02	1.392
Impaired BRCA2 binding to RAD51	R-HSA-9709570	4.055510e-02	1.392
Platelet calcium homeostasis	R-HSA-418360	4.055510e-02	1.392
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.236851e-02	1.373
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	4.240637e-02	1.373
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	4.250853e-02	1.372
Meiotic recombination	R-HSA-912446	4.299981e-02	1.367
Gene Silencing by RNA	R-HSA-211000	4.366652e-02	1.360
Reproduction	R-HSA-1474165	4.395982e-02	1.357
MAPK1/MAPK3 signaling	R-HSA-5684996	4.512086e-02	1.346
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.605794e-02	1.337
Signaling by ERBB2	R-HSA-1227986	4.605794e-02	1.337
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.605794e-02	1.337
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.605794e-02	1.337
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.605794e-02	1.337
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.605794e-02	1.337
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.605794e-02	1.337
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	4.605794e-02	1.337
Cellular response to chemical stress	R-HSA-9711123	4.678597e-02	1.330
Reduction of cytosolic Ca++ levels	R-HSA-418359	4.744968e-02	1.324
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.744968e-02	1.324
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	4.767480e-02	1.322
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	4.823159e-02	1.317
Assembly of the pre-replicative complex	R-HSA-68867	4.860292e-02	1.313
MAPK family signaling cascades	R-HSA-5683057	4.900102e-02	1.310
Circadian clock	R-HSA-9909396	4.915035e-02	1.308
DNA Replication Pre-Initiation	R-HSA-69002	4.944941e-02	1.306
Glycogen storage diseases	R-HSA-3229121	4.987139e-02	1.302
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	5.068739e-02	1.295
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	5.068739e-02	1.295
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	5.068739e-02	1.295
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	5.068739e-02	1.295
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	5.068739e-02	1.295
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	5.068739e-02	1.295
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	5.068739e-02	1.295
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	5.068739e-02	1.295
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	5.068739e-02	1.295
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	5.068739e-02	1.295
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	5.068739e-02	1.295
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	5.164343e-02	1.287
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	5.190365e-02	1.285
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.222929e-02	1.282
Regulation of CDH1 Gene Transcription	R-HSA-9764560	5.222929e-02	1.282
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	5.266783e-02	1.278
Potential therapeutics for SARS	R-HSA-9679191	5.349013e-02	1.272
Signaling by TGFB family members	R-HSA-9006936	5.537449e-02	1.257
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	5.739962e-02	1.241
IRAK1 recruits IKK complex	R-HSA-937039	5.739962e-02	1.241
VLDLR internalisation and degradation	R-HSA-8866427	5.739962e-02	1.241
Signaling by MET	R-HSA-6806834	5.769612e-02	1.239
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	5.828471e-02	1.234
Signaling by PTK6	R-HSA-8848021	5.880238e-02	1.231
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.880238e-02	1.231
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	5.920127e-02	1.228
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	6.063010e-02	1.217
Signaling by NOTCH3	R-HSA-9012852	6.108030e-02	1.214
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.205941e-02	1.207
TRIF-mediated programmed cell death	R-HSA-2562578	6.205941e-02	1.207
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.205941e-02	1.207
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.205941e-02	1.207
Uptake and function of diphtheria toxin	R-HSA-5336415	6.205941e-02	1.207
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	6.285395e-02	1.202
Sema4D in semaphorin signaling	R-HSA-400685	6.285395e-02	1.202
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	6.447007e-02	1.191
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	6.447007e-02	1.191
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.447007e-02	1.191
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	6.447007e-02	1.191
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	8.565865e-02	1.067
FasL/ CD95L signaling	R-HSA-75157	7.476783e-02	1.126
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	7.476783e-02	1.126
Regulation by c-FLIP	R-HSA-3371378	7.750639e-02	1.111
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.750639e-02	1.111
Dimerization of procaspase-8	R-HSA-69416	7.750639e-02	1.111
Signaling by MRAS-complex mutants	R-HSA-9660537	7.750639e-02	1.111
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	7.750639e-02	1.111
Regulated proteolysis of p75NTR	R-HSA-193692	9.445068e-02	1.025
CASP8 activity is inhibited	R-HSA-5218900	9.445068e-02	1.025
ALK mutants bind TKIs	R-HSA-9700645	9.445068e-02	1.025
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	8.035035e-02	1.095
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	8.035035e-02	1.095
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	9.328745e-02	1.030
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	7.659666e-02	1.116
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	7.925409e-02	1.101
PRC2 methylates histones and DNA	R-HSA-212300	9.541723e-02	1.020
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.477820e-02	1.023
Formation of RNA Pol II elongation complex	R-HSA-112382	9.477820e-02	1.023
Regulation of PTEN gene transcription	R-HSA-8943724	8.976559e-02	1.047
Nuclear Receptor transcription pathway	R-HSA-383280	9.100247e-02	1.041
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	7.077985e-02	1.150
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.799819e-02	1.108
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	7.659666e-02	1.116
Resolution of D-Loop Structures	R-HSA-5693537	7.154518e-02	1.145
Sema3A PAK dependent Axon repulsion	R-HSA-399954	9.328745e-02	1.030
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	7.750639e-02	1.111
Translesion synthesis by REV1	R-HSA-110312	9.328745e-02	1.030
VEGFR2 mediated vascular permeability	R-HSA-5218920	7.061475e-02	1.151
Neurexins and neuroligins	R-HSA-6794361	9.477820e-02	1.023
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.906276e-02	1.102
Signal transduction by L1	R-HSA-445144	7.659666e-02	1.116
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	7.475711e-02	1.126
Protein-protein interactions at synapses	R-HSA-6794362	8.029614e-02	1.095
Translation	R-HSA-72766	9.762764e-02	1.010
Regulation of NPAS4 gene transcription	R-HSA-9768777	9.445068e-02	1.025
GP1b-IX-V activation signalling	R-HSA-430116	9.445068e-02	1.025
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	7.906276e-02	1.102
Activation of BAD and translocation to mitochondria	R-HSA-111447	9.328745e-02	1.030
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.659666e-02	1.116
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	7.077985e-02	1.150
EPH-Ephrin signaling	R-HSA-2682334	8.014464e-02	1.096
Cellular response to starvation	R-HSA-9711097	7.827039e-02	1.106
Signaling by NOTCH1	R-HSA-1980143	8.000231e-02	1.097
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.794687e-02	1.009
Glycogen synthesis	R-HSA-3322077	7.659666e-02	1.116
Regulated Necrosis	R-HSA-5218859	8.481195e-02	1.072
NGF-stimulated transcription	R-HSA-9031628	6.871625e-02	1.163
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	7.476783e-02	1.126
Inactivation of CDC42 and RAC1	R-HSA-428543	9.445068e-02	1.025
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	6.837554e-02	1.165
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.827176e-02	1.054
Negative regulation of FGFR4 signaling	R-HSA-5654733	9.782500e-02	1.010
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.906276e-02	1.102
Oxidative Stress Induced Senescence	R-HSA-2559580	8.905710e-02	1.050
Signaling by NTRK1 (TRKA)	R-HSA-187037	9.819342e-02	1.008
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	8.441987e-02	1.074
Pyruvate metabolism	R-HSA-70268	9.623422e-02	1.017
MAP kinase activation	R-HSA-450294	9.633139e-02	1.016
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	8.057024e-02	1.094
Signaling by Hedgehog	R-HSA-5358351	7.074120e-02	1.150
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	8.692777e-02	1.061
Signaling by NOTCH2	R-HSA-1980145	7.906276e-02	1.102
Butyrophilin (BTN) family interactions	R-HSA-8851680	9.445068e-02	1.025
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	7.077985e-02	1.150
MITF-M-regulated melanocyte development	R-HSA-9730414	7.641703e-02	1.117
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.483261e-02	1.126
FLT3 Signaling	R-HSA-9607240	7.061475e-02	1.151
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	6.837554e-02	1.165
Response of Mtb to phagocytosis	R-HSA-9637690	9.187549e-02	1.037
Transcriptional Regulation by MECP2	R-HSA-8986944	7.097768e-02	1.149
Transport to the Golgi and subsequent modification	R-HSA-948021	1.015565e-01	0.993
Regulation of gap junction activity	R-HSA-191650	1.016892e-01	0.993
NADE modulates death signalling	R-HSA-205025	1.016892e-01	0.993
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.016892e-01	0.993
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.020827e-01	0.991
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.020827e-01	0.991
Signaling by FGFR2	R-HSA-5654738	1.028859e-01	0.988
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.031728e-01	0.986
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	1.050348e-01	0.979
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.060127e-01	0.975
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	1.071420e-01	0.970
Translesion synthesis by POLI	R-HSA-5656121	1.071420e-01	0.970
Prolonged ERK activation events	R-HSA-169893	1.071420e-01	0.970
Regulation of NF-kappa B signaling	R-HSA-9758274	1.071420e-01	0.970
Regulation of BACH1 activity	R-HSA-9708530	1.071420e-01	0.970
Cellular responses to mechanical stimuli	R-HSA-9855142	1.076276e-01	0.968
Activation of BH3-only proteins	R-HSA-114452	1.079031e-01	0.967
FGFR2 alternative splicing	R-HSA-6803529	1.096329e-01	0.960
mTORC1-mediated signalling	R-HSA-166208	1.096329e-01	0.960
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.096991e-01	0.960
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.098929e-01	0.959
SARS-CoV-1 Infection	R-HSA-9678108	1.109216e-01	0.955
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	1.127575e-01	0.948
CASP4 inflammasome assembly	R-HSA-9948001	1.127575e-01	0.948
Chromatin modifying enzymes	R-HSA-3247509	1.144115e-01	0.942
PTEN Regulation	R-HSA-6807070	1.145988e-01	0.941
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.156490e-01	0.937
S Phase	R-HSA-69242	1.162425e-01	0.935
Signaling by NTRKs	R-HSA-166520	1.162425e-01	0.935
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.164220e-01	0.934
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.164220e-01	0.934
Regulation of pyruvate metabolism	R-HSA-9861718	1.164220e-01	0.934
Diseases of DNA repair	R-HSA-9675135	1.164220e-01	0.934
Switching of origins to a post-replicative state	R-HSA-69052	1.169369e-01	0.932
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.176239e-01	0.930
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.176749e-01	0.929
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.184929e-01	0.926
Translesion synthesis by POLK	R-HSA-5655862	1.218623e-01	0.914
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.218623e-01	0.914
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.218623e-01	0.914
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.218623e-01	0.914
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.218623e-01	0.914
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.218623e-01	0.914
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.219609e-01	0.914
Plasma lipoprotein clearance	R-HSA-8964043	1.231670e-01	0.910
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.241051e-01	0.906
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.253141e-01	0.902
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.253141e-01	0.902
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.258528e-01	0.900
Signaling by WNT	R-HSA-195721	1.285613e-01	0.891
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.292805e-01	0.888
Diseases of mitotic cell cycle	R-HSA-9675126	1.295784e-01	0.887
Adherens junctions interactions	R-HSA-418990	1.302949e-01	0.885
IRS activation	R-HSA-74713	1.307888e-01	0.883
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	1.307888e-01	0.883
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.307888e-01	0.883
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	1.307888e-01	0.883
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.314794e-01	0.881
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.322840e-01	0.878
Glycogen metabolism	R-HSA-8982491	1.332411e-01	0.875
Chromatin organization	R-HSA-4839726	1.342638e-01	0.872
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.343803e-01	0.872
Gluconeogenesis	R-HSA-70263	1.345498e-01	0.871
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.349020e-01	0.870
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.373910e-01	0.862
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.373910e-01	0.862
MyD88-independent TLR4 cascade	R-HSA-166166	1.397159e-01	0.855
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.397159e-01	0.855
TCR signaling	R-HSA-202403	1.397159e-01	0.855
Nuclear RNA decay	R-HSA-9930044	1.411417e-01	0.850
Activation of ATR in response to replication stress	R-HSA-176187	1.411417e-01	0.850
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.411417e-01	0.850
Regulation of MECP2 expression and activity	R-HSA-9022692	1.411417e-01	0.850
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.411417e-01	0.850
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.411417e-01	0.850
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.430795e-01	0.844
Dual incision in TC-NER	R-HSA-6782135	1.432004e-01	0.844
Selenoamino acid metabolism	R-HSA-2408522	1.478374e-01	0.830
ATP-dependent chromatin remodelers	R-HSA-9932444	1.484244e-01	0.828
SWI/SNF chromatin remodelers	R-HSA-9932451	1.484244e-01	0.828
Interleukin-7 signaling	R-HSA-1266695	1.484244e-01	0.828
TGFBR3 expression	R-HSA-9839394	1.484244e-01	0.828
Generic Transcription Pathway	R-HSA-212436	1.510481e-01	0.821
Signaling by Interleukins	R-HSA-449147	1.523489e-01	0.817
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.531626e-01	0.815
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.639846e-01	0.785
Diseases of Telomere Maintenance	R-HSA-9673013	1.639846e-01	0.785
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.639846e-01	0.785
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.639846e-01	0.785
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.639846e-01	0.785
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.639846e-01	0.785
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.639846e-01	0.785
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.639846e-01	0.785
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.639846e-01	0.785
TICAM1 deficiency - HSE	R-HSA-5602566	1.639846e-01	0.785
TGFBR2 MSI Frameshift Mutants in Cancer	R-HSA-3642279	1.639846e-01	0.785
NFG and proNGF binds to p75NTR	R-HSA-205017	2.356050e-01	0.628
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.356050e-01	0.628
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.356050e-01	0.628
Signaling by TCF7L2 mutants	R-HSA-5339700	2.356050e-01	0.628
PTEN Loss of Function in Cancer	R-HSA-5674404	2.356050e-01	0.628
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.356050e-01	0.628
TRAF3 deficiency - HSE	R-HSA-5602571	2.356050e-01	0.628
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.010937e-01	0.521
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.010937e-01	0.521
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.010937e-01	0.521
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.010937e-01	0.521
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.010937e-01	0.521
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.010937e-01	0.521
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.010937e-01	0.521
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	1.933239e-01	0.714
Activated NTRK2 signals through CDK5	R-HSA-9032845	2.258542e-01	0.646
IFNG signaling activates MAPKs	R-HSA-9732724	2.258542e-01	0.646
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	2.258542e-01	0.646
SOS-mediated signalling	R-HSA-112412	2.258542e-01	0.646
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.744085e-01	0.758
ROBO receptors bind AKAP5	R-HSA-9010642	2.587337e-01	0.587
Type I hemidesmosome assembly	R-HSA-446107	2.587337e-01	0.587
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.967139e-01	0.706
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.536664e-01	0.813
GAB1 signalosome	R-HSA-180292	1.536664e-01	0.813
ARMS-mediated activation	R-HSA-170984	2.916641e-01	0.535
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.916641e-01	0.535
Lipophagy	R-HSA-9613354	2.916641e-01	0.535
WNT mediated activation of DVL	R-HSA-201688	2.916641e-01	0.535
MAPK1 (ERK2) activation	R-HSA-112411	2.916641e-01	0.535
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.431057e-01	0.614
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.063118e-01	0.685
EPHA-mediated growth cone collapse	R-HSA-3928663	1.770722e-01	0.752
Interaction between L1 and Ankyrins	R-HSA-445095	1.770722e-01	0.752
Class I peroxisomal membrane protein import	R-HSA-9603798	2.669274e-01	0.574
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.669274e-01	0.574
Phosphorylation of the APC/C	R-HSA-176412	2.669274e-01	0.574
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.669274e-01	0.574
DNA methylation	R-HSA-5334118	2.076029e-01	0.683
G beta:gamma signalling through CDC42	R-HSA-8964616	2.910022e-01	0.536
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.910022e-01	0.536
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.910022e-01	0.536
Activation of the pre-replicative complex	R-HSA-68962	2.234733e-01	0.651
SIRT1 negatively regulates rRNA expression	R-HSA-427359	2.053612e-01	0.687
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.828596e-01	0.548
Deadenylation of mRNA	R-HSA-429947	2.828596e-01	0.548
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.855475e-01	0.732
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.855475e-01	0.732
Condensation of Prophase Chromosomes	R-HSA-2299718	2.139209e-01	0.670
mRNA Splicing - Minor Pathway	R-HSA-72165	2.139209e-01	0.670
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.674701e-01	0.776
Integrin signaling	R-HSA-354192	2.730032e-01	0.564
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.481029e-01	0.605
HDACs deacetylate histones	R-HSA-3214815	2.079766e-01	0.682
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	2.195720e-01	0.658
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	2.939400e-01	0.532
Regulation of PTEN stability and activity	R-HSA-8948751	1.855475e-01	0.732
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	3.072020e-01	0.513
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	2.266934e-01	0.645
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.686060e-01	0.571
Degradation of DVL	R-HSA-4641258	2.053612e-01	0.687
Asymmetric localization of PCP proteins	R-HSA-4608870	2.014226e-01	0.696
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.766304e-01	0.753
Degradation of GLI1 by the proteasome	R-HSA-5610780	2.778875e-01	0.556
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.547521e-01	0.810
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.258542e-01	0.646
Regulation of Apoptosis	R-HSA-169911	1.784882e-01	0.748
Regulation of RAS by GAPs	R-HSA-5658442	2.664497e-01	0.574
Deadenylation-dependent mRNA decay	R-HSA-429914	2.556985e-01	0.592
Regulation of mitotic cell cycle	R-HSA-453276	2.803499e-01	0.552
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.803499e-01	0.552
MTOR signalling	R-HSA-165159	1.657669e-01	0.781
Epigenetic regulation of gene expression	R-HSA-212165	2.401794e-01	0.619
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	2.900125e-01	0.538
Ca-dependent events	R-HSA-111996	1.657669e-01	0.781
Degradation of CRY and PER proteins	R-HSA-9932298	2.778875e-01	0.556
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.054449e-01	0.687
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.744085e-01	0.758
Microbial factors inhibit CASP4 activity	R-HSA-9956593	1.967139e-01	0.706
CaM pathway	R-HSA-111997	1.917442e-01	0.717
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.481029e-01	0.605
Orc1 removal from chromatin	R-HSA-68949	2.939400e-01	0.532
PLC beta mediated events	R-HSA-112043	2.807387e-01	0.552
Calmodulin induced events	R-HSA-111933	1.917442e-01	0.717
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.536664e-01	0.813
Rap1 signalling	R-HSA-392517	1.706234e-01	0.768
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.076029e-01	0.683
Activation of NF-kappaB in B cells	R-HSA-1169091	2.801106e-01	0.553
Activation and oligomerization of BAK protein	R-HSA-111452	1.639846e-01	0.785
Abacavir transmembrane transport	R-HSA-2161517	1.933239e-01	0.714
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	2.258542e-01	0.646
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.744085e-01	0.758
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.234733e-01	0.651
Hh mutants are degraded by ERAD	R-HSA-5362768	2.628855e-01	0.580
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	2.628855e-01	0.580
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	1.624934e-01	0.789
Frs2-mediated activation	R-HSA-170968	1.967139e-01	0.706
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.682603e-01	0.571
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.614966e-01	0.792
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.431057e-01	0.614
Transcriptional regulation by RUNX3	R-HSA-8878159	1.776592e-01	0.750
Regulation of NFE2L2 gene expression	R-HSA-9818749	1.933239e-01	0.714
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.730032e-01	0.564
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.628855e-01	0.580
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	1.545554e-01	0.811
Platelet activation, signaling and aggregation	R-HSA-76002	1.543627e-01	0.811
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	1.706234e-01	0.768
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	2.014226e-01	0.696
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	2.014226e-01	0.696
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.784882e-01	0.748
Stabilization of p53	R-HSA-69541	2.335688e-01	0.632
Activation, translocation and oligomerization of BAX	R-HSA-114294	1.639846e-01	0.785
Inhibition of PKR	R-HSA-169131	1.639846e-01	0.785
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.356050e-01	0.628
Transport of connexins along the secretory pathway	R-HSA-190827	2.356050e-01	0.628
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.356050e-01	0.628
Signalling to ERK5	R-HSA-198765	3.010937e-01	0.521
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.010937e-01	0.521
Physiological factors	R-HSA-5578768	2.196582e-01	0.658
Cellular response to mitochondrial stress	R-HSA-9840373	2.916641e-01	0.535
Unwinding of DNA	R-HSA-176974	2.916641e-01	0.535
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.656193e-01	0.781
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.656193e-01	0.781
Notch-HLH transcription pathway	R-HSA-350054	2.439062e-01	0.613
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.966302e-01	0.706
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	1.812538e-01	0.742
Negative regulation of NOTCH4 signaling	R-HSA-9604323	2.481029e-01	0.605
Signaling by VEGF	R-HSA-194138	1.960830e-01	0.708
Response of endothelial cells to shear stress	R-HSA-9860931	1.574568e-01	0.803
DNA Replication	R-HSA-69306	2.773781e-01	0.557
C-type lectin receptors (CLRs)	R-HSA-5621481	2.638725e-01	0.579
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.388890e-01	0.622
Interleukin-1 signaling	R-HSA-9020702	3.061891e-01	0.514
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.860184e-01	0.730
G1/S DNA Damage Checkpoints	R-HSA-69615	3.063884e-01	0.514
Nef and signal transduction	R-HSA-164944	1.933239e-01	0.714
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	2.916641e-01	0.535
Vpu mediated degradation of CD4	R-HSA-180534	2.900125e-01	0.538
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	3.072020e-01	0.513
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.072020e-01	0.513
Cardiac conduction	R-HSA-5576891	1.755184e-01	0.756
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	2.529789e-01	0.597
Calnexin/calreticulin cycle	R-HSA-901042	1.656193e-01	0.781
rRNA modification in the nucleus and cytosol	R-HSA-6790901	1.914161e-01	0.718
RSV-host interactions	R-HSA-9833110	1.646404e-01	0.783
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	1.770722e-01	0.752
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.784882e-01	0.748
Signaling by TGFBR3	R-HSA-9839373	2.139209e-01	0.670
Signaling by FGFR4	R-HSA-5654743	1.773270e-01	0.751
Developmental Biology	R-HSA-1266738	2.035879e-01	0.691
Oligomerization of connexins into connexons	R-HSA-190704	2.356050e-01	0.628
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.614966e-01	0.792
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.669274e-01	0.574
Defective pyroptosis	R-HSA-9710421	1.773270e-01	0.751
Regulation of RUNX3 expression and activity	R-HSA-8941858	2.481029e-01	0.605
Signaling by NOTCH	R-HSA-157118	1.868205e-01	0.729
Adaptive Immune System	R-HSA-1280218	1.711691e-01	0.767
Signaling by FGFR3	R-HSA-5654741	2.014226e-01	0.696
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.766304e-01	0.753
Hemostasis	R-HSA-109582	2.531705e-01	0.597
Cell-cell junction organization	R-HSA-421270	1.906390e-01	0.720
Interleukin-17 signaling	R-HSA-448424	1.674701e-01	0.776
Signaling by NOTCH4	R-HSA-9013694	2.054449e-01	0.687
Signaling by FGFR	R-HSA-190236	2.759011e-01	0.559
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	2.196582e-01	0.658
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.455913e-01	0.610
Amyloid fiber formation	R-HSA-977225	2.792845e-01	0.554
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	1.747423e-01	0.758
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.922338e-01	0.534
Adrenoceptors	R-HSA-390696	2.587337e-01	0.587
Sodium/Proton exchangers	R-HSA-425986	2.587337e-01	0.587
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	2.434488e-01	0.614
ER Quality Control Compartment (ERQC)	R-HSA-901032	1.770722e-01	0.752
Transcriptional regulation of granulopoiesis	R-HSA-9616222	2.934958e-01	0.532
Transcriptional Regulation by NPAS4	R-HSA-9634815	2.939400e-01	0.532
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.258542e-01	0.646
Respiratory syncytial virus genome replication	R-HSA-9834752	2.916641e-01	0.535
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.431057e-01	0.614
Heme signaling	R-HSA-9707616	2.934958e-01	0.532
Stimuli-sensing channels	R-HSA-2672351	1.949916e-01	0.710
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.536664e-01	0.813
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.063118e-01	0.685
MITF-M-dependent gene expression	R-HSA-9856651	1.825535e-01	0.739
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.910022e-01	0.536
Interleukin-37 signaling	R-HSA-9008059	2.234733e-01	0.651
Non-canonical inflammasome activation	R-HSA-9686114	2.196582e-01	0.658
DCC mediated attractive signaling	R-HSA-418885	2.431057e-01	0.614
Hh mutants abrogate ligand secretion	R-HSA-5387390	3.084329e-01	0.511
HCMV Late Events	R-HSA-9610379	3.096191e-01	0.509
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.152168e-01	0.501
Elevation of cytosolic Ca2+ levels	R-HSA-139853	3.152168e-01	0.501
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.152168e-01	0.501
Regulation of NPAS4 gene expression	R-HSA-9768759	3.152168e-01	0.501
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	3.152168e-01	0.501
PI Metabolism	R-HSA-1483255	3.164761e-01	0.500
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.226473e-01	0.491
TRP channels	R-HSA-3295583	3.226473e-01	0.491
Suppression of phagosomal maturation	R-HSA-9637687	3.226473e-01	0.491
Co-inhibition by PD-1	R-HSA-389948	3.229732e-01	0.491
G1 Phase	R-HSA-69236	3.239185e-01	0.490
Cyclin D associated events in G1	R-HSA-69231	3.239185e-01	0.490
RMTs methylate histone arginines	R-HSA-3214858	3.239185e-01	0.490
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.243957e-01	0.489
PI3K/AKT activation	R-HSA-198203	3.243957e-01	0.489
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	3.243957e-01	0.489
Signal attenuation	R-HSA-74749	3.243957e-01	0.489
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.243957e-01	0.489
Signaling by Leptin	R-HSA-2586552	3.243957e-01	0.489
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	3.245315e-01	0.489
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	3.245315e-01	0.489
MAPK6/MAPK4 signaling	R-HSA-5687128	3.245666e-01	0.489
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	3.285879e-01	0.483
Neutrophil degranulation	R-HSA-6798695	3.305925e-01	0.481
Toll-like Receptor Cascades	R-HSA-168898	3.353791e-01	0.474
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	3.361267e-01	0.473
Opioid Signalling	R-HSA-111885	3.372869e-01	0.472
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.394667e-01	0.469
Ephrin signaling	R-HSA-3928664	3.394667e-01	0.469
Polo-like kinase mediated events	R-HSA-156711	3.394667e-01	0.469
Platelet sensitization by LDL	R-HSA-432142	3.394667e-01	0.469
Fanconi Anemia Pathway	R-HSA-6783310	3.395082e-01	0.469
DAG and IP3 signaling	R-HSA-1489509	3.395082e-01	0.469
Defective CFTR causes cystic fibrosis	R-HSA-5678895	3.395082e-01	0.469
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.395082e-01	0.469
Deubiquitination	R-HSA-5688426	3.413510e-01	0.467
Vif-mediated degradation of APOBEC3G	R-HSA-180585	3.419613e-01	0.466
Cristae formation	R-HSA-8949613	3.426997e-01	0.465
RNA Polymerase I Promoter Opening	R-HSA-73728	3.426997e-01	0.465
Regulation of T cell activation by CD28 family	R-HSA-388841	3.481441e-01	0.458
Intrinsic Pathway for Apoptosis	R-HSA-109606	3.505094e-01	0.455
Signaling by FGFR1	R-HSA-5654736	3.505094e-01	0.455
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	3.505094e-01	0.455
PECAM1 interactions	R-HSA-210990	3.567209e-01	0.448
Signaling by APC mutants	R-HSA-4839744	3.567209e-01	0.448
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	3.567209e-01	0.448
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	3.567209e-01	0.448
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	3.567209e-01	0.448
Bicarbonate transporters	R-HSA-425381	3.567209e-01	0.448
Synthesis of PI	R-HSA-1483226	3.567209e-01	0.448
Suppression of apoptosis	R-HSA-9635465	3.567209e-01	0.448
Interleukin-1 family signaling	R-HSA-446652	3.570609e-01	0.447
G-protein mediated events	R-HSA-112040	3.589744e-01	0.445
Degradation of AXIN	R-HSA-4641257	3.594531e-01	0.444
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	3.594531e-01	0.444
Axonal growth stimulation	R-HSA-209563	3.609753e-01	0.443
MET activates PTPN11	R-HSA-8865999	3.609753e-01	0.443
STAT6-mediated induction of chemokines	R-HSA-3249367	3.609753e-01	0.443
MET interacts with TNS proteins	R-HSA-8875513	3.609753e-01	0.443
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.609753e-01	0.443
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.625374e-01	0.441
Phase 0 - rapid depolarisation	R-HSA-5576892	3.627810e-01	0.440
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.636559e-01	0.439
Signaling by FGFR2 IIIa TM	R-HSA-8851708	3.636559e-01	0.439
STING mediated induction of host immune responses	R-HSA-1834941	3.636559e-01	0.439
Other interleukin signaling	R-HSA-449836	3.636559e-01	0.439
Pre-NOTCH Processing in Golgi	R-HSA-1912420	3.636559e-01	0.439
Transcriptional regulation by RUNX1	R-HSA-8878171	3.643121e-01	0.439
PCP/CE pathway	R-HSA-4086400	3.657079e-01	0.437
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	3.708888e-01	0.431
MET promotes cell motility	R-HSA-8875878	3.769701e-01	0.424
Immune System	R-HSA-168256	3.774321e-01	0.423
Sensory processing of sound	R-HSA-9659379	3.781879e-01	0.422
Synthesis of DNA	R-HSA-69239	3.796224e-01	0.421
Signaling by Erythropoietin	R-HSA-9006335	3.828374e-01	0.417
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.828374e-01	0.417
DARPP-32 events	R-HSA-180024	3.828374e-01	0.417
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.876972e-01	0.412
Formation of ATP by chemiosmotic coupling	R-HSA-163210	3.876972e-01	0.412
Formation of definitive endoderm	R-HSA-9823730	3.876972e-01	0.412
VxPx cargo-targeting to cilium	R-HSA-5620916	3.876972e-01	0.412
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.884693e-01	0.411
Signaling by GSK3beta mutants	R-HSA-5339716	3.884693e-01	0.411
Sensing of DNA Double Strand Breaks	R-HSA-5693548	3.884693e-01	0.411
Signaling by AMER1 mutants	R-HSA-4839748	3.884693e-01	0.411
Signaling by AXIN mutants	R-HSA-4839735	3.884693e-01	0.411
Activation of RAC1	R-HSA-428540	3.884693e-01	0.411
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	3.906989e-01	0.408
Peroxisomal protein import	R-HSA-9033241	3.936570e-01	0.405
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	3.944767e-01	0.404
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	3.944767e-01	0.404
RAS processing	R-HSA-9648002	3.944767e-01	0.404
Signaling by ALK	R-HSA-201556	3.944767e-01	0.404
Developmental Cell Lineages	R-HSA-9734767	3.964866e-01	0.402
Beta-catenin independent WNT signaling	R-HSA-3858494	3.977467e-01	0.400
FOXO-mediated transcription	R-HSA-9614085	3.981784e-01	0.400
Cyclin E associated events during G1/S transition	R-HSA-69202	3.990134e-01	0.399
Class I MHC mediated antigen processing & presentation	R-HSA-983169	4.020910e-01	0.396
Degradation of CDH1	R-HSA-9766229	4.023604e-01	0.395
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.023604e-01	0.395
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.023604e-01	0.395
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.028183e-01	0.395
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.028183e-01	0.395
Sphingolipid de novo biosynthesis	R-HSA-1660661	4.080679e-01	0.389
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.115116e-01	0.386
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.119391e-01	0.385
Generation of second messenger molecules	R-HSA-202433	4.119391e-01	0.385
Intracellular signaling by second messengers	R-HSA-9006925	4.130728e-01	0.384
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.157296e-01	0.381
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.157296e-01	0.381
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.157296e-01	0.381
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.157296e-01	0.381
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.157296e-01	0.381
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.157296e-01	0.381
Signaling by MAP2K mutants	R-HSA-9652169	4.157296e-01	0.381
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.157296e-01	0.381
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.157296e-01	0.381
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	4.157296e-01	0.381
TNFR1-mediated ceramide production	R-HSA-5626978	4.157296e-01	0.381
Dopamine receptors	R-HSA-390651	4.157296e-01	0.381
RUNX3 regulates p14-ARF	R-HSA-8951936	4.195026e-01	0.377
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.195026e-01	0.377
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	4.195026e-01	0.377
Scavenging by Class F Receptors	R-HSA-3000484	4.195026e-01	0.377
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	4.195026e-01	0.377
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	4.195026e-01	0.377
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	4.195026e-01	0.377
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	4.195026e-01	0.377
Repression of WNT target genes	R-HSA-4641265	4.195026e-01	0.377
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	4.195026e-01	0.377
Regulation of IFNG signaling	R-HSA-877312	4.195026e-01	0.377
Signaling by LTK	R-HSA-9842663	4.195026e-01	0.377
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.195026e-01	0.377
Regulation of RUNX2 expression and activity	R-HSA-8939902	4.224607e-01	0.374
Trafficking of AMPA receptors	R-HSA-399719	4.226766e-01	0.374
trans-Golgi Network Vesicle Budding	R-HSA-199992	4.257502e-01	0.371
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	4.293250e-01	0.367
Transcriptional Regulation by VENTX	R-HSA-8853884	4.293250e-01	0.367
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	4.293250e-01	0.367
Transmission across Chemical Synapses	R-HSA-112315	4.318587e-01	0.365
Hedgehog ligand biogenesis	R-HSA-5358346	4.337217e-01	0.363
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.350288e-01	0.361
Serine metabolism	R-HSA-977347	4.350288e-01	0.361
Signaling by PDGFR in disease	R-HSA-9671555	4.350288e-01	0.361
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	4.368170e-01	0.360
Signaling by WNT in cancer	R-HSA-4791275	4.423686e-01	0.354
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.466041e-01	0.350
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.466041e-01	0.350
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.497103e-01	0.347
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.497103e-01	0.347
Interleukin-6 signaling	R-HSA-1059683	4.497103e-01	0.347
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	4.497103e-01	0.347
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.497103e-01	0.347
CD28 dependent Vav1 pathway	R-HSA-389359	4.497103e-01	0.347
Regulation of IFNA/IFNB signaling	R-HSA-912694	4.581862e-01	0.339
RAF-independent MAPK1/3 activation	R-HSA-112409	4.581862e-01	0.339
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	4.581862e-01	0.339
Assembly of the ORC complex at the origin of replication	R-HSA-68616	4.618538e-01	0.335
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	4.618538e-01	0.335
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.647871e-01	0.333
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	4.657017e-01	0.332
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	4.657952e-01	0.332
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.657952e-01	0.332
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	4.657952e-01	0.332
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.657952e-01	0.332
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	4.657952e-01	0.332
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	4.657952e-01	0.332
PTK6 Down-Regulation	R-HSA-8849472	4.657952e-01	0.332
Reelin signalling pathway	R-HSA-8866376	4.657952e-01	0.332
Muscarinic acetylcholine receptors	R-HSA-390648	4.657952e-01	0.332
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.657952e-01	0.332
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.657952e-01	0.332
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.657952e-01	0.332
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.657952e-01	0.332
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	4.657952e-01	0.332
Assembly of Viral Components at the Budding Site	R-HSA-168316	4.657952e-01	0.332
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.732719e-01	0.325
TP53 Regulates Metabolic Genes	R-HSA-5628897	4.759547e-01	0.322
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	4.780786e-01	0.321
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	4.790061e-01	0.320
CRMPs in Sema3A signaling	R-HSA-399956	4.790061e-01	0.320
Regulation of KIT signaling	R-HSA-1433559	4.790061e-01	0.320
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	4.809289e-01	0.318
Syndecan interactions	R-HSA-3000170	4.809289e-01	0.318
Growth hormone receptor signaling	R-HSA-982772	4.809289e-01	0.318
Effects of PIP2 hydrolysis	R-HSA-114508	4.810954e-01	0.318
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	4.810954e-01	0.318
G1/S Transition	R-HSA-69206	4.854521e-01	0.314
Platelet homeostasis	R-HSA-418346	4.877527e-01	0.312
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.890211e-01	0.311
EPHB-mediated forward signaling	R-HSA-3928662	4.975233e-01	0.303
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	4.975233e-01	0.303
Netrin-1 signaling	R-HSA-373752	4.975233e-01	0.303
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	5.000598e-01	0.301
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	5.000598e-01	0.301
NPAS4 regulates expression of target genes	R-HSA-9768919	5.000598e-01	0.301
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	5.032092e-01	0.298
TRAF6 mediated NF-kB activation	R-HSA-933542	5.032092e-01	0.298
Estrogen-dependent gene expression	R-HSA-9018519	5.039061e-01	0.298
Integration of energy metabolism	R-HSA-163685	5.039061e-01	0.298
Erythropoietin activates RAS	R-HSA-9027284	5.073245e-01	0.295
Beta-catenin phosphorylation cascade	R-HSA-196299	5.073245e-01	0.295
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.073245e-01	0.295
Biotin transport and metabolism	R-HSA-196780	5.073245e-01	0.295
Neuronal System	R-HSA-112316	5.081041e-01	0.294
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	5.097826e-01	0.293
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.115735e-01	0.291
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.115735e-01	0.291
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.115735e-01	0.291
PKB-mediated events	R-HSA-109703	5.115735e-01	0.291
PDE3B signalling	R-HSA-165160	5.115735e-01	0.291
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.115735e-01	0.291
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.115735e-01	0.291
IkBA variant leads to EDA-ID	R-HSA-5603029	5.115735e-01	0.291
Signaling by RNF43 mutants	R-HSA-5340588	5.115735e-01	0.291
TRAIL signaling	R-HSA-75158	5.115735e-01	0.291
Pentose phosphate pathway disease	R-HSA-6791465	5.115735e-01	0.291
Cam-PDE 1 activation	R-HSA-111957	5.115735e-01	0.291
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.115735e-01	0.291
Ceramide signalling	R-HSA-193681	5.115735e-01	0.291
Noncanonical activation of NOTCH3	R-HSA-9017802	5.115735e-01	0.291
Signalling to p38 via RIT and RIN	R-HSA-187706	5.115735e-01	0.291
CLEC7A/inflammasome pathway	R-HSA-5660668	5.115735e-01	0.291
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	5.115735e-01	0.291
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.115735e-01	0.291
Regulation of CDH19 Expression and Function	R-HSA-9764302	5.115735e-01	0.291
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.115735e-01	0.291
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.121386e-01	0.291
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.121386e-01	0.291
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.121386e-01	0.291
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.141073e-01	0.289
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	5.141073e-01	0.289
Signalling to ERKs	R-HSA-187687	5.187167e-01	0.285
MyD88 dependent cascade initiated on endosome	R-HSA-975155	5.206995e-01	0.283
HATs acetylate histones	R-HSA-3214847	5.235816e-01	0.281
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	5.249863e-01	0.280
tRNA processing	R-HSA-72306	5.255213e-01	0.279
Downstream TCR signaling	R-HSA-202424	5.268291e-01	0.278
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.346180e-01	0.272
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	5.346180e-01	0.272
RET signaling	R-HSA-8853659	5.370390e-01	0.270
RUNX2 regulates bone development	R-HSA-8941326	5.370390e-01	0.270
PIP3 activates AKT signaling	R-HSA-1257604	5.415844e-01	0.266
Myogenesis	R-HSA-525793	5.462256e-01	0.263
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	5.462256e-01	0.263
Abacavir ADME	R-HSA-2161522	5.462256e-01	0.263
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.534313e-01	0.257
Chylomicron clearance	R-HSA-8964026	5.534313e-01	0.257
Signaling by LTK in cancer	R-HSA-9842640	5.534313e-01	0.257
Erythropoietin activates STAT5	R-HSA-9027283	5.534313e-01	0.257
Autointegration results in viral DNA circles	R-HSA-177539	5.534313e-01	0.257
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.534313e-01	0.257
Integration of viral DNA into host genomic DNA	R-HSA-175567	5.534313e-01	0.257
CREB phosphorylation	R-HSA-199920	5.534313e-01	0.257
TRAF6 mediated IRF7 activation	R-HSA-933541	5.550027e-01	0.256
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	5.599841e-01	0.252
Synthesis of PG	R-HSA-1483148	5.608542e-01	0.251
NoRC negatively regulates rRNA expression	R-HSA-427413	5.616945e-01	0.250
Hedgehog 'on' state	R-HSA-5632684	5.616945e-01	0.250
Co-stimulation by CD28	R-HSA-389356	5.623947e-01	0.250
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.635501e-01	0.249
Protein localization	R-HSA-9609507	5.667263e-01	0.247
Packaging Of Telomere Ends	R-HSA-171306	5.668987e-01	0.246
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.668987e-01	0.246
Signaling by NTRK2 (TRKB)	R-HSA-9006115	5.668987e-01	0.246
Maternal to zygotic transition (MZT)	R-HSA-9816359	5.693076e-01	0.245
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.860139e-01	0.232
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	5.860139e-01	0.232
PI3K events in ERBB2 signaling	R-HSA-1963642	5.860139e-01	0.232
Specification of primordial germ cells	R-HSA-9827857	5.860139e-01	0.232
Uptake and function of anthrax toxins	R-HSA-5210891	5.860139e-01	0.232
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.869823e-01	0.231
Formation of the Early Elongation Complex	R-HSA-113418	5.869823e-01	0.231
HIV elongation arrest and recovery	R-HSA-167287	5.869823e-01	0.231
Pausing and recovery of HIV elongation	R-HSA-167290	5.869823e-01	0.231
Ca2+ pathway	R-HSA-4086398	5.877808e-01	0.231
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	5.897734e-01	0.229
MET activates PI3K/AKT signaling	R-HSA-8851907	5.917042e-01	0.228
RUNX3 regulates WNT signaling	R-HSA-8951430	5.917042e-01	0.228
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	5.917042e-01	0.228
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	5.917042e-01	0.228
Recycling of eIF2:GDP	R-HSA-72731	5.917042e-01	0.228
PTK6 Expression	R-HSA-8849473	5.917042e-01	0.228
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	5.917042e-01	0.228
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.917042e-01	0.228
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	5.917042e-01	0.228
VLDL clearance	R-HSA-8964046	5.917042e-01	0.228
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	5.917042e-01	0.228
CHL1 interactions	R-HSA-447041	5.917042e-01	0.228
Displacement of DNA glycosylase by APEX1	R-HSA-110357	5.917042e-01	0.228
Maturation of replicase proteins	R-HSA-9694301	5.917042e-01	0.228
Signaling by FGFR in disease	R-HSA-1226099	6.005300e-01	0.221
Interferon alpha/beta signaling	R-HSA-909733	6.047966e-01	0.218
mRNA Capping	R-HSA-72086	6.064584e-01	0.217
HIV Transcription Elongation	R-HSA-167169	6.065469e-01	0.217
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	6.065469e-01	0.217
Mitotic G1 phase and G1/S transition	R-HSA-453279	6.070087e-01	0.217
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	6.081342e-01	0.216
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	6.094875e-01	0.215
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.100889e-01	0.215
PKA activation	R-HSA-163615	6.100889e-01	0.215
Synaptic adhesion-like molecules	R-HSA-8849932	6.100889e-01	0.215
Mismatch Repair	R-HSA-5358508	6.100889e-01	0.215
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	6.108012e-01	0.214
Signaling by Nuclear Receptors	R-HSA-9006931	6.123648e-01	0.213
RNA Polymerase I Promoter Escape	R-HSA-73772	6.227524e-01	0.206
Uptake and actions of bacterial toxins	R-HSA-5339562	6.227524e-01	0.206
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.228943e-01	0.206
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.228943e-01	0.206
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	6.253135e-01	0.204
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	6.253135e-01	0.204
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.253989e-01	0.204
UCH proteinases	R-HSA-5689603	6.253989e-01	0.204
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	6.266991e-01	0.203
phospho-PLA2 pathway	R-HSA-111995	6.266991e-01	0.203
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.266991e-01	0.203
MET receptor recycling	R-HSA-8875656	6.266991e-01	0.203
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.266991e-01	0.203
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.266991e-01	0.203
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.266991e-01	0.203
Interleukin-9 signaling	R-HSA-8985947	6.266991e-01	0.203
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	6.266991e-01	0.203
TGFBR3 PTM regulation	R-HSA-9839383	6.266991e-01	0.203
The NLRP3 inflammasome	R-HSA-844456	6.330804e-01	0.199
Cellular response to hypoxia	R-HSA-1234174	6.368245e-01	0.196
Signaling by FGFR1 in disease	R-HSA-5655302	6.388053e-01	0.195
Translation of Structural Proteins	R-HSA-9683701	6.388053e-01	0.195
Unfolded Protein Response (UPR)	R-HSA-381119	6.394888e-01	0.194
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.441034e-01	0.191
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.441034e-01	0.191
Transcriptional regulation by RUNX2	R-HSA-8878166	6.441034e-01	0.191
RNA Polymerase I Transcription	R-HSA-73864	6.493816e-01	0.188
ER-Phagosome pathway	R-HSA-1236974	6.498611e-01	0.187
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	6.542717e-01	0.184
Cleavage of the damaged pyrimidine	R-HSA-110329	6.542717e-01	0.184
Depyrimidination	R-HSA-73928	6.542717e-01	0.184
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	6.549971e-01	0.184
Signaling by NODAL	R-HSA-1181150	6.549971e-01	0.184
Protein hydroxylation	R-HSA-9629569	6.549971e-01	0.184
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	6.570366e-01	0.182
Interleukin-21 signaling	R-HSA-9020958	6.586964e-01	0.181
p75NTR regulates axonogenesis	R-HSA-193697	6.586964e-01	0.181
MASTL Facilitates Mitotic Progression	R-HSA-2465910	6.586964e-01	0.181
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.586964e-01	0.181
Regulation of signaling by NODAL	R-HSA-1433617	6.586964e-01	0.181
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.586964e-01	0.181
AKT phosphorylates targets in the nucleus	R-HSA-198693	6.586964e-01	0.181
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	6.586964e-01	0.181
Regulation of CDH11 gene transcription	R-HSA-9762293	6.586964e-01	0.181
Interleukin-1 processing	R-HSA-448706	6.586964e-01	0.181
Defects in biotin (Btn) metabolism	R-HSA-3323169	6.586964e-01	0.181
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	6.586964e-01	0.181
DNA strand elongation	R-HSA-69190	6.611277e-01	0.180
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	6.611277e-01	0.180
ABC-family proteins mediated transport	R-HSA-382556	6.611360e-01	0.180
Chromosome Maintenance	R-HSA-73886	6.629454e-01	0.179
Neddylation	R-HSA-8951664	6.638319e-01	0.178
Adipogenesis	R-HSA-9843745	6.642108e-01	0.178
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.721516e-01	0.173
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.721516e-01	0.173
Transcription of the HIV genome	R-HSA-167172	6.743655e-01	0.171
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	6.743655e-01	0.171
G-protein activation	R-HSA-202040	6.758544e-01	0.170
PKA-mediated phosphorylation of CREB	R-HSA-111931	6.758544e-01	0.170
Early Phase of HIV Life Cycle	R-HSA-162594	6.758544e-01	0.170
Zygotic genome activation (ZGA)	R-HSA-9819196	6.758544e-01	0.170
Basigin interactions	R-HSA-210991	6.758544e-01	0.170
Detoxification of Reactive Oxygen Species	R-HSA-3299685	6.778443e-01	0.169
G-protein beta:gamma signalling	R-HSA-397795	6.780792e-01	0.169
FGFR1 mutant receptor activation	R-HSA-1839124	6.780792e-01	0.169
Pre-NOTCH Expression and Processing	R-HSA-1912422	6.810162e-01	0.167
Amine ligand-binding receptors	R-HSA-375280	6.838485e-01	0.165
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	6.863095e-01	0.163
Infectious disease	R-HSA-5663205	6.870870e-01	0.163
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	6.879529e-01	0.162
Regulation of the apoptosome activity	R-HSA-9627069	6.879529e-01	0.162
Regulation of CDH11 function	R-HSA-9762292	6.879529e-01	0.162
Formation of apoptosome	R-HSA-111458	6.879529e-01	0.162
Binding and entry of HIV virion	R-HSA-173107	6.879529e-01	0.162
EGFR Transactivation by Gastrin	R-HSA-2179392	6.879529e-01	0.162
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	6.879529e-01	0.162
Interleukin-27 signaling	R-HSA-9020956	6.879529e-01	0.162
2-LTR circle formation	R-HSA-164843	6.879529e-01	0.162
Receptor Mediated Mitophagy	R-HSA-8934903	6.879529e-01	0.162
MAPK3 (ERK1) activation	R-HSA-110056	6.879529e-01	0.162
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	6.879529e-01	0.162
Synthesis of PA	R-HSA-1483166	6.907430e-01	0.161
Miscellaneous transport and binding events	R-HSA-5223345	6.943940e-01	0.158
Heme degradation	R-HSA-189483	6.943940e-01	0.158
Nucleosome assembly	R-HSA-774815	6.979524e-01	0.156
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	6.979524e-01	0.156
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.144773e-01	0.146
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	7.144773e-01	0.146
LDL clearance	R-HSA-8964038	7.144773e-01	0.146
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.144773e-01	0.146
Interleukin-2 signaling	R-HSA-9020558	7.147031e-01	0.146
Ionotropic activity of kainate receptors	R-HSA-451306	7.147031e-01	0.146
vRNA Synthesis	R-HSA-192814	7.147031e-01	0.146
vRNP Assembly	R-HSA-192905	7.147031e-01	0.146
Conjugation of benzoate with glycine	R-HSA-177135	7.147031e-01	0.146
RHOBTB3 ATPase cycle	R-HSA-9706019	7.147031e-01	0.146
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	7.147031e-01	0.146
Chylomicron assembly	R-HSA-8963888	7.147031e-01	0.146
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.147031e-01	0.146
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.147031e-01	0.146
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.147031e-01	0.146
Transport of RCbl within the body	R-HSA-9758890	7.147031e-01	0.146
Diseases of carbohydrate metabolism	R-HSA-5663084	7.311550e-01	0.136
Regulation of PTEN mRNA translation	R-HSA-8943723	7.322958e-01	0.135
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.322958e-01	0.135
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	7.322958e-01	0.135
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.322958e-01	0.135
Mitochondrial biogenesis	R-HSA-1592230	7.343442e-01	0.134
Ub-specific processing proteases	R-HSA-5689880	7.358390e-01	0.133
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	7.375237e-01	0.132
Metal ion SLC transporters	R-HSA-425410	7.375237e-01	0.132
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.391615e-01	0.131
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.391615e-01	0.131
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.391615e-01	0.131
Integration of provirus	R-HSA-162592	7.391615e-01	0.131
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	7.391615e-01	0.131
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.391615e-01	0.131
ERKs are inactivated	R-HSA-202670	7.391615e-01	0.131
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.391615e-01	0.131
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.391615e-01	0.131
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.391615e-01	0.131
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.391615e-01	0.131
Sodium/Calcium exchangers	R-HSA-425561	7.391615e-01	0.131
FGFR2 mutant receptor activation	R-HSA-1839126	7.395664e-01	0.131
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.426254e-01	0.129
XBP1(S) activates chaperone genes	R-HSA-381038	7.453680e-01	0.128
Interleukin-6 family signaling	R-HSA-6783589	7.491592e-01	0.125
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.491592e-01	0.125
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.491592e-01	0.125
Mitochondrial RNA degradation	R-HSA-9836573	7.491592e-01	0.125
Complex III assembly	R-HSA-9865881	7.491592e-01	0.125
Telomere Maintenance	R-HSA-157579	7.495863e-01	0.125
Iron uptake and transport	R-HSA-917937	7.518036e-01	0.124
Cleavage of the damaged purine	R-HSA-110331	7.533937e-01	0.123
Post-translational protein phosphorylation	R-HSA-8957275	7.583603e-01	0.120
Interleukin-15 signaling	R-HSA-8983432	7.615245e-01	0.118
RUNX3 regulates NOTCH signaling	R-HSA-8941856	7.615245e-01	0.118
GRB2 events in EGFR signaling	R-HSA-179812	7.615245e-01	0.118
Interleukin-35 Signalling	R-HSA-8984722	7.615245e-01	0.118
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.615245e-01	0.118
Conjugation of salicylate with glycine	R-HSA-177128	7.615245e-01	0.118
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.615245e-01	0.118
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.615245e-01	0.118
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.615245e-01	0.118
Polymerase switching	R-HSA-69091	7.615245e-01	0.118
Leading Strand Synthesis	R-HSA-69109	7.615245e-01	0.118
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.615245e-01	0.118
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.615245e-01	0.118
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	7.615245e-01	0.118
Pervasive developmental disorders	R-HSA-9005895	7.615245e-01	0.118
Disorders of Nervous System Development	R-HSA-9697154	7.615245e-01	0.118
OAS antiviral response	R-HSA-8983711	7.615245e-01	0.118
PI3K Cascade	R-HSA-109704	7.616468e-01	0.118
Signaling by FGFR2 in disease	R-HSA-5655253	7.616468e-01	0.118
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.651003e-01	0.116
Activation of G protein gated Potassium channels	R-HSA-1296041	7.651003e-01	0.116
G protein gated Potassium channels	R-HSA-1296059	7.651003e-01	0.116
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.651003e-01	0.116
Acyl chain remodelling of PS	R-HSA-1482801	7.651003e-01	0.116
VEGFR2 mediated cell proliferation	R-HSA-5218921	7.651003e-01	0.116
Tight junction interactions	R-HSA-420029	7.651003e-01	0.116
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.651003e-01	0.116
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.651003e-01	0.116
Depurination	R-HSA-73927	7.666238e-01	0.115
Translation of Structural Proteins	R-HSA-9694635	7.712737e-01	0.113
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	7.792698e-01	0.108
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	7.799914e-01	0.108
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.801532e-01	0.108
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.801532e-01	0.108
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.801532e-01	0.108
ABC transporter disorders	R-HSA-5619084	7.805711e-01	0.108
Base Excision Repair	R-HSA-73884	7.815139e-01	0.107
Chylomicron remodeling	R-HSA-8963901	7.819714e-01	0.107
Formation of axial mesoderm	R-HSA-9796292	7.819714e-01	0.107
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	7.819714e-01	0.107
Processing of SMDT1	R-HSA-8949664	7.819714e-01	0.107
PI5P Regulates TP53 Acetylation	R-HSA-6811555	7.819714e-01	0.107
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	7.819714e-01	0.107
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	7.819714e-01	0.107
Pre-NOTCH Transcription and Translation	R-HSA-1912408	7.899264e-01	0.102
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.943530e-01	0.100
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	7.943530e-01	0.100
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	7.943530e-01	0.100
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.943530e-01	0.100
Insulin processing	R-HSA-264876	7.943530e-01	0.100
IRE1alpha activates chaperones	R-HSA-381070	7.980930e-01	0.098
Removal of the Flap Intermediate	R-HSA-69166	8.006663e-01	0.097
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.006663e-01	0.097
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.006663e-01	0.097
Transport of fatty acids	R-HSA-804914	8.006663e-01	0.097
Hydrolysis of LPC	R-HSA-1483115	8.006663e-01	0.097
Retrograde neurotrophin signalling	R-HSA-177504	8.006663e-01	0.097
Signaling by FGFR4 in disease	R-HSA-5655291	8.006663e-01	0.097
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.006663e-01	0.097
Ciprofloxacin ADME	R-HSA-9793528	8.006663e-01	0.097
Acyl chain remodeling of CL	R-HSA-1482798	8.006663e-01	0.097
Zinc transporters	R-HSA-435354	8.006663e-01	0.097
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	8.025385e-01	0.096
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	8.025385e-01	0.096
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	8.025385e-01	0.096
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.046697e-01	0.094
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.060161e-01	0.094
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.067456e-01	0.093
Telomere Extension By Telomerase	R-HSA-171319	8.077353e-01	0.093
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.077353e-01	0.093
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.077353e-01	0.093
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.077353e-01	0.093
Inflammasomes	R-HSA-622312	8.077353e-01	0.093
Activation of HOX genes during differentiation	R-HSA-5619507	8.136643e-01	0.090
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	8.136643e-01	0.090
Intra-Golgi traffic	R-HSA-6811438	8.138474e-01	0.089
Scavenging by Class A Receptors	R-HSA-3000480	8.138474e-01	0.089
SHC1 events in EGFR signaling	R-HSA-180336	8.177592e-01	0.087
G beta:gamma signalling through BTK	R-HSA-8964315	8.177592e-01	0.087
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.177592e-01	0.087
Processive synthesis on the lagging strand	R-HSA-69183	8.177592e-01	0.087
Telomere C-strand synthesis initiation	R-HSA-174430	8.177592e-01	0.087
Protein lipoylation	R-HSA-9857492	8.177592e-01	0.087
DNA Damage Reversal	R-HSA-73942	8.177592e-01	0.087
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.177592e-01	0.087
Lysosphingolipid and LPA receptors	R-HSA-419408	8.177592e-01	0.087
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	8.177592e-01	0.087
Regulation of CDH11 Expression and Function	R-HSA-9759475	8.203359e-01	0.086
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	8.203359e-01	0.086
RNA Polymerase I Transcription Initiation	R-HSA-73762	8.243055e-01	0.084
Fatty acyl-CoA biosynthesis	R-HSA-75105	8.262808e-01	0.083
ESR-mediated signaling	R-HSA-8939211	8.280453e-01	0.082
SHC1 events in ERBB2 signaling	R-HSA-1250196	8.321903e-01	0.080
DAP12 signaling	R-HSA-2424491	8.321903e-01	0.080
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.321903e-01	0.080
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.321903e-01	0.080
IRS-mediated signalling	R-HSA-112399	8.326161e-01	0.080
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.333874e-01	0.079
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.333874e-01	0.079
Killing mechanisms	R-HSA-9664420	8.333874e-01	0.079
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.333874e-01	0.079
Differentiation of T cells	R-HSA-9945266	8.333874e-01	0.079
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.333874e-01	0.079
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.333874e-01	0.079
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.333874e-01	0.079
Attachment and Entry	R-HSA-9678110	8.333874e-01	0.079
Atorvastatin ADME	R-HSA-9754706	8.333874e-01	0.079
Virus Assembly and Release	R-HSA-168268	8.333874e-01	0.079
Signaling by SCF-KIT	R-HSA-1433557	8.342571e-01	0.079
Asparagine N-linked glycosylation	R-HSA-446203	8.398840e-01	0.076
Antigen processing-Cross presentation	R-HSA-1236975	8.406125e-01	0.075
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.433339e-01	0.074
Glycine degradation	R-HSA-6783984	8.476761e-01	0.072
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.476761e-01	0.072
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.476761e-01	0.072
tRNA modification in the mitochondrion	R-HSA-6787450	8.476761e-01	0.072
Disorders of Developmental Biology	R-HSA-9675151	8.476761e-01	0.072
Coenzyme A biosynthesis	R-HSA-196783	8.476761e-01	0.072
Acetylcholine regulates insulin secretion	R-HSA-399997	8.476761e-01	0.072
G0 and Early G1	R-HSA-1538133	8.538013e-01	0.069
Inwardly rectifying K+ channels	R-HSA-1296065	8.538013e-01	0.069
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.538013e-01	0.069
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.607403e-01	0.065
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	8.607403e-01	0.065
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.607403e-01	0.065
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	8.636265e-01	0.064
Cardiogenesis	R-HSA-9733709	8.636265e-01	0.064
IRS-related events triggered by IGF1R	R-HSA-2428928	8.646121e-01	0.063
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.726847e-01	0.059
G beta:gamma signalling through PLC beta	R-HSA-418217	8.726847e-01	0.059
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	8.726847e-01	0.059
Presynaptic function of Kainate receptors	R-HSA-500657	8.726847e-01	0.059
PKA activation in glucagon signalling	R-HSA-164378	8.726847e-01	0.059
Apoptotic factor-mediated response	R-HSA-111471	8.726847e-01	0.059
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	8.726847e-01	0.059
Vitamin D (calciferol) metabolism	R-HSA-196791	8.726847e-01	0.059
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	8.726847e-01	0.059
Acyl chain remodelling of PC	R-HSA-1482788	8.728426e-01	0.059
Glucagon signaling in metabolic regulation	R-HSA-163359	8.728426e-01	0.059
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.728426e-01	0.059
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	8.802567e-01	0.055
Disease	R-HSA-1643685	8.810651e-01	0.055
Signal amplification	R-HSA-392518	8.814819e-01	0.055
eNOS activation	R-HSA-203615	8.814819e-01	0.055
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.814819e-01	0.055
PI-3K cascade:FGFR3	R-HSA-5654710	8.836053e-01	0.054
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.836053e-01	0.054
Germ layer formation at gastrulation	R-HSA-9754189	8.836053e-01	0.054
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	8.836053e-01	0.054
Conjugation of carboxylic acids	R-HSA-159424	8.836053e-01	0.054
Amino Acid conjugation	R-HSA-156587	8.836053e-01	0.054
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	8.836053e-01	0.054
E2F mediated regulation of DNA replication	R-HSA-113510	8.836053e-01	0.054
HDL remodeling	R-HSA-8964058	8.836053e-01	0.054
Maturation of nucleoprotein	R-HSA-9694631	8.836053e-01	0.054
IGF1R signaling cascade	R-HSA-2428924	8.850319e-01	0.053
Insulin receptor signalling cascade	R-HSA-74751	8.850319e-01	0.053
Acyl chain remodelling of PE	R-HSA-1482839	8.895754e-01	0.051
PERK regulates gene expression	R-HSA-381042	8.895754e-01	0.051
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	8.912154e-01	0.050
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.929548e-01	0.049
PI-3K cascade:FGFR4	R-HSA-5654720	8.935897e-01	0.049
Co-inhibition by CTLA4	R-HSA-389513	8.935897e-01	0.049
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.935897e-01	0.049
Creatine metabolism	R-HSA-71288	8.935897e-01	0.049
Acyl chain remodelling of PI	R-HSA-1482922	8.935897e-01	0.049
Pregnenolone biosynthesis	R-HSA-196108	8.935897e-01	0.049
FCGR3A-mediated phagocytosis	R-HSA-9664422	8.945160e-01	0.048
Parasite infection	R-HSA-9664407	8.945160e-01	0.048
Leishmania phagocytosis	R-HSA-9664417	8.945160e-01	0.048
G1/S-Specific Transcription	R-HSA-69205	8.971531e-01	0.047
GPVI-mediated activation cascade	R-HSA-114604	8.971531e-01	0.047
Glycosphingolipid transport	R-HSA-9845576	8.971531e-01	0.047
SLC transporter disorders	R-HSA-5619102	9.000242e-01	0.046
Post-translational protein modification	R-HSA-597592	9.023800e-01	0.045
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.027182e-01	0.044
Lagging Strand Synthesis	R-HSA-69186	9.027182e-01	0.044
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.027182e-01	0.044
ERK/MAPK targets	R-HSA-198753	9.027182e-01	0.044
Abacavir metabolism	R-HSA-2161541	9.027182e-01	0.044
Acyl chain remodelling of PG	R-HSA-1482925	9.027182e-01	0.044
Voltage gated Potassium channels	R-HSA-1296072	9.042441e-01	0.044
Collagen chain trimerization	R-HSA-8948216	9.042441e-01	0.044
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.092050e-01	0.041
Amino acids regulate mTORC1	R-HSA-9639288	9.096906e-01	0.041
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.108759e-01	0.041
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.108759e-01	0.041
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	9.110641e-01	0.040
Mitochondrial calcium ion transport	R-HSA-8949215	9.110641e-01	0.040
Molybdenum cofactor biosynthesis	R-HSA-947581	9.110641e-01	0.040
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.110641e-01	0.040
Androgen biosynthesis	R-HSA-193048	9.110641e-01	0.040
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.110641e-01	0.040
Attachment and Entry	R-HSA-9694614	9.110641e-01	0.040
Disorders of transmembrane transporters	R-HSA-5619115	9.118633e-01	0.040
FCERI mediated NF-kB activation	R-HSA-2871837	9.136005e-01	0.039
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.152129e-01	0.038
Pentose phosphate pathway	R-HSA-71336	9.170751e-01	0.038
Interferon gamma signaling	R-HSA-877300	9.185080e-01	0.037
PI-3K cascade:FGFR1	R-HSA-5654689	9.186945e-01	0.037
G alpha (z) signalling events	R-HSA-418597	9.203915e-01	0.036
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.228672e-01	0.035
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.228672e-01	0.035
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.228672e-01	0.035
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.228672e-01	0.035
Diseases of Immune System	R-HSA-5260271	9.228672e-01	0.035
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.228672e-01	0.035
Interleukin receptor SHC signaling	R-HSA-912526	9.256706e-01	0.034
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.256706e-01	0.034
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.256706e-01	0.034
Interleukin-20 family signaling	R-HSA-8854691	9.256706e-01	0.034
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.256706e-01	0.034
Mitochondrial mRNA modification	R-HSA-9937008	9.256706e-01	0.034
Organic anion transport by SLCO transporters	R-HSA-879518	9.256706e-01	0.034
Carnitine shuttle	R-HSA-200425	9.256706e-01	0.034
ABC transporters in lipid homeostasis	R-HSA-1369062	9.256706e-01	0.034
Formation of the cornified envelope	R-HSA-6809371	9.258598e-01	0.033
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.282763e-01	0.032
Thromboxane signalling through TP receptor	R-HSA-428930	9.320485e-01	0.031
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.320485e-01	0.031
Synthesis of dolichyl-phosphate	R-HSA-446199	9.320485e-01	0.031
Plasma lipoprotein assembly	R-HSA-8963898	9.320485e-01	0.031
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.333255e-01	0.030
HIV Transcription Initiation	R-HSA-167161	9.333255e-01	0.030
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.333255e-01	0.030
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.333255e-01	0.030
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.342822e-01	0.030
Extra-nuclear estrogen signaling	R-HSA-9009391	9.346718e-01	0.029
PI-3K cascade:FGFR2	R-HSA-5654695	9.378795e-01	0.028
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.378795e-01	0.028
Hyaluronan degradation	R-HSA-2160916	9.378795e-01	0.028
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.378795e-01	0.028
Laminin interactions	R-HSA-3000157	9.378795e-01	0.028
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	9.380368e-01	0.028
Cytosolic tRNA aminoacylation	R-HSA-379716	9.380368e-01	0.028
Activation of GABAB receptors	R-HSA-991365	9.380368e-01	0.028
GABA B receptor activation	R-HSA-977444	9.380368e-01	0.028
Extension of Telomeres	R-HSA-180786	9.383915e-01	0.028
Amino acid transport across the plasma membrane	R-HSA-352230	9.383915e-01	0.028
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.383915e-01	0.028
Metabolism of steroids	R-HSA-8957322	9.402755e-01	0.027
Neurotransmitter release cycle	R-HSA-112310	9.408621e-01	0.026
Metabolism of proteins	R-HSA-392499	9.412448e-01	0.026
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.421001e-01	0.026
tRNA Aminoacylation	R-HSA-379724	9.422619e-01	0.026
RNA Polymerase II Promoter Escape	R-HSA-73776	9.424308e-01	0.026
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.432105e-01	0.025
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.432105e-01	0.025
Urea cycle	R-HSA-70635	9.432105e-01	0.025
Sphingolipid catabolism	R-HSA-9845614	9.432105e-01	0.025
Collagen degradation	R-HSA-1442490	9.459057e-01	0.024
Proteasome assembly	R-HSA-9907900	9.465274e-01	0.024
DAP12 interactions	R-HSA-2172127	9.465274e-01	0.024
RNA Polymerase I Transcription Termination	R-HSA-73863	9.480843e-01	0.023
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.480843e-01	0.023
Signaling by FGFR3 in disease	R-HSA-5655332	9.480843e-01	0.023
Integrin cell surface interactions	R-HSA-216083	9.486538e-01	0.023
Cholesterol biosynthesis	R-HSA-191273	9.486538e-01	0.023
Mitochondrial protein import	R-HSA-1268020	9.493347e-01	0.023
Signaling by Insulin receptor	R-HSA-74752	9.498997e-01	0.022
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.503452e-01	0.022
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.503452e-01	0.022
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.503452e-01	0.022
Prednisone ADME	R-HSA-9757110	9.525400e-01	0.021
Insulin receptor recycling	R-HSA-77387	9.525400e-01	0.021
Pyroptosis	R-HSA-5620971	9.525400e-01	0.021
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.539018e-01	0.020
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.539018e-01	0.020
Downstream signaling of activated FGFR3	R-HSA-5654708	9.566136e-01	0.019
Glucagon-type ligand receptors	R-HSA-420092	9.566136e-01	0.019
Phospholipid metabolism	R-HSA-1483257	9.572703e-01	0.019
GPER1 signaling	R-HSA-9634597	9.602976e-01	0.018
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.603378e-01	0.018
Downstream signaling of activated FGFR4	R-HSA-5654716	9.603378e-01	0.018
Neurotransmitter clearance	R-HSA-112311	9.603378e-01	0.018
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.611220e-01	0.017
Cytoprotection by HMOX1	R-HSA-9707564	9.620687e-01	0.017
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.629776e-01	0.016
SLC-mediated transport of amino acids	R-HSA-9958863	9.636374e-01	0.016
Cargo concentration in the ER	R-HSA-5694530	9.637425e-01	0.016
Molecules associated with elastic fibres	R-HSA-2129379	9.637425e-01	0.016
Downstream signal transduction	R-HSA-186763	9.637425e-01	0.016
Azathioprine ADME	R-HSA-9748787	9.658370e-01	0.015
Regulation of insulin secretion	R-HSA-422356	9.663081e-01	0.015
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.668551e-01	0.015
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.673411e-01	0.014
COPII-mediated vesicle transport	R-HSA-204005	9.702945e-01	0.013
PPARA activates gene expression	R-HSA-1989781	9.717063e-01	0.012
Metabolism of porphyrins	R-HSA-189445	9.722445e-01	0.012
Nucleotide biosynthesis	R-HSA-8956320	9.727748e-01	0.012
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.743148e-01	0.011
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.746803e-01	0.011
RA biosynthesis pathway	R-HSA-5365859	9.746803e-01	0.011
Hyaluronan metabolism	R-HSA-2142845	9.746803e-01	0.011
Paracetamol ADME	R-HSA-9753281	9.766216e-01	0.010
Downstream signaling of activated FGFR2	R-HSA-5654696	9.768544e-01	0.010
Downstream signaling of activated FGFR1	R-HSA-5654687	9.768544e-01	0.010
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.768544e-01	0.010
Lysosome Vesicle Biogenesis	R-HSA-432720	9.788420e-01	0.009
Triglyceride catabolism	R-HSA-163560	9.788420e-01	0.009
Metabolism of folate and pterines	R-HSA-196757	9.806590e-01	0.008
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.806590e-01	0.008
SLC-mediated transport of organic cations	R-HSA-549127	9.806590e-01	0.008
Innate Immune System	R-HSA-168249	9.811395e-01	0.008
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.821424e-01	0.008
tRNA processing in the mitochondrion	R-HSA-6785470	9.823201e-01	0.008
Elastic fibre formation	R-HSA-1566948	9.823201e-01	0.008
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.823201e-01	0.008
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.823201e-01	0.008
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.832547e-01	0.007
Mitochondrial protein degradation	R-HSA-9837999	9.832547e-01	0.007
Collagen formation	R-HSA-1474290	9.832547e-01	0.007
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.838386e-01	0.007
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.838386e-01	0.007
GABA receptor activation	R-HSA-977443	9.840767e-01	0.007
Parasitic Infection Pathways	R-HSA-9824443	9.844005e-01	0.007
Leishmania infection	R-HSA-9658195	9.844005e-01	0.007
Interleukin-2 family signaling	R-HSA-451927	9.852267e-01	0.006
rRNA processing in the mitochondrion	R-HSA-8868766	9.852267e-01	0.006
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.852267e-01	0.006
Tryptophan catabolism	R-HSA-71240	9.852267e-01	0.006
Aquaporin-mediated transport	R-HSA-445717	9.852614e-01	0.006
Formation of paraxial mesoderm	R-HSA-9793380	9.852614e-01	0.006
Potassium Channels	R-HSA-1296071	9.862106e-01	0.006
NCAM signaling for neurite out-growth	R-HSA-375165	9.863603e-01	0.006
Signaling by PDGF	R-HSA-186797	9.863603e-01	0.006
Maturation of spike protein	R-HSA-9694548	9.864957e-01	0.006
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.876558e-01	0.005
Heme biosynthesis	R-HSA-189451	9.876558e-01	0.005
Synthesis of bile acids and bile salts	R-HSA-192105	9.886660e-01	0.005
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.887163e-01	0.005
Extracellular matrix organization	R-HSA-1474244	9.887174e-01	0.005
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.894100e-01	0.005
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.896857e-01	0.005
Pyrimidine catabolism	R-HSA-73621	9.896857e-01	0.005
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.905719e-01	0.004
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.905719e-01	0.004
Metabolism of steroid hormones	R-HSA-196071	9.907622e-01	0.004
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.909087e-01	0.004
Degradation of the extracellular matrix	R-HSA-1474228	9.911308e-01	0.004
Somitogenesis	R-HSA-9824272	9.913820e-01	0.004
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.914585e-01	0.004
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.921225e-01	0.003
Gastrulation	R-HSA-9758941	9.923747e-01	0.003
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.927995e-01	0.003
Class B/2 (Secretin family receptors)	R-HSA-373080	9.931747e-01	0.003
Metabolism of cofactors	R-HSA-8978934	9.932536e-01	0.003
Plasma lipoprotein remodeling	R-HSA-8963899	9.934183e-01	0.003
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.937654e-01	0.003
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.938578e-01	0.003
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.939839e-01	0.003
Chemokine receptors bind chemokines	R-HSA-380108	9.939839e-01	0.003
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.945010e-01	0.002
Bile acid and bile salt metabolism	R-HSA-194068	9.949150e-01	0.002
The phototransduction cascade	R-HSA-2514856	9.949737e-01	0.002
FCERI mediated MAPK activation	R-HSA-2871796	9.955618e-01	0.002
Role of phospholipids in phagocytosis	R-HSA-2029485	9.968502e-01	0.001
Dectin-2 family	R-HSA-5621480	9.970691e-01	0.001
Peptide hormone metabolism	R-HSA-2980736	9.972569e-01	0.001
Triglyceride metabolism	R-HSA-8979227	9.975515e-01	0.001
Regulation of beta-cell development	R-HSA-186712	9.975515e-01	0.001
Peroxisomal lipid metabolism	R-HSA-390918	9.976032e-01	0.001
Sphingolipid metabolism	R-HSA-428157	9.976071e-01	0.001
Signaling by Retinoic Acid	R-HSA-5362517	9.977620e-01	0.001
Metabolism of polyamines	R-HSA-351202	9.977620e-01	0.001
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.978462e-01	0.001
Complex I biogenesis	R-HSA-6799198	9.982913e-01	0.001
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.988076e-01	0.001
O-linked glycosylation of mucins	R-HSA-913709	9.989102e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.990897e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.991681e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.991681e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.992052e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.992888e-01	0.000
Aspirin ADME	R-HSA-9749641	9.993051e-01	0.000
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.993649e-01	0.000
Keratinization	R-HSA-6805567	9.993776e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.993960e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.994196e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.995569e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.995569e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.995895e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.995951e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.995991e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.996618e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.997055e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.997747e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.998063e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.998112e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.998507e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.998507e-01	0.000
Transport of small molecules	R-HSA-382551	9.999043e-01	0.000
Drug ADME	R-HSA-9748784	9.999096e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999200e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999411e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999597e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999626e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999673e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999696e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999842e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999868e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999896e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999943e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999955e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999960e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999976e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999982e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999987e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999988e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999990e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999990e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999993e-01	0.000
Infection with Enterobacteria	R-HSA-9640148	9.999995e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999996e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999998e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999999e-01	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000