GCN2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Log-Odds: S Sites / S Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O43390 T134 Sugiyama HNRNPR HNRPR KVQESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O43390 Y136 Sugiyama HNRNPR HNRPR QESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60506 T131 Sugiyama SYNCRIP HNRPQ NSAP1 KVADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O60506 Y133 Sugiyama SYNCRIP HNRPQ NSAP1 ADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S190 Sugiyama EIF5B IF2 KIAA0741 NsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGP
O60841 S196 Sugiyama EIF5B IF2 KIAA0741 ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P05198 S52 SIGNOR EIF2S1 EIF2A AYVSLLEYNNIEGMILLsELsRRRIRSINKLIRIGRNECVV
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S29 Sugiyama RPLP2 D11S2243E RPP2 LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P09923 S111 Sugiyama ALPI DRFPYLALSKTYNVDRQVPDsAATATAYLCGVKANFQTIGL
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P25205 S704 Sugiyama MCM3 DQEQKRKRRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPK
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26583 S35 Sugiyama HMGB2 HMG2 syAFFVQtCREEHKKKHPDssVNFAEFSKKCSERWKTMSAK
P30043 S198 Sugiyama BLVRB FLR SCAN KHDLGHFMLRCLttDEyDGHstyPsHQyQ____________
P35579 S1713 Sugiyama MYH9 ERAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQ
P35579 S1714 Sugiyama MYH9 RAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQL
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P55081 T267 Sugiyama MFAP1 ETKKELEENKRsLAALDALNtDDENDEEEyEAWKVRELKRI
P56192 S229 EPSD|PSP MARS1 MARS sPAEGRAVTNEPEEEELATLsEEEIAMAVTAWEKGLESLPP
P56192 S472 EPSD|PSP MARS1 MARS LDLPKLEKRLEEWLGRTLPGsDWTPNAQFITRSWLRDGLKP
P56192 S662 SIGNOR|EPSD|PSP MARS1 MARS NNSELLNNLGNFINRAGMFVsKFFGGYVPEMVLTPDDQRLL
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 S238 Sugiyama RPS3A FTE1 MFTL LKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyEP
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
Q14152 S1028 Sugiyama EIF3A EIF3S10 KIAA0139 NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q6PKG0 S627 Sugiyama LARP1 KIAA0731 LARP FLFDEEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVt
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q86W56 Y832 Sugiyama PARG DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q9NYF8 S320 Sugiyama BCLAF1 BTF KIAA0164 sPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRF
Q9P2K8 S1036 Sugiyama EIF2AK4 GCN2 KIAA1338 HHTLTNVDGKAYRTMMAQIFsQRISPAIDYTYDsDILKGNF
Q9P2K8 S1049 Sugiyama EIF2AK4 GCN2 KIAA1338 TMMAQIFsQRISPAIDYTYDsDILKGNFSIRTAKMQQHVCE
Q9P2K8 S1504 Sugiyama EIF2AK4 GCN2 KIAA1338 DHVLQKLRTKVTDERNGREAsDNLAVQNLKGsFsNASGLFE
Q9P2K8 S205 Sugiyama EIF2AK4 GCN2 KIAA1338 EIKEEKKRKEMAKQERLEIAsLsNQDHtsKKDPGGHRTAAI
Q9P2K8 S207 Sugiyama EIF2AK4 GCN2 KIAA1338 KEEKKRKEMAKQERLEIAsLsNQDHtsKKDPGGHRTAAILH
Q9P2K8 S230 Sugiyama EIF2AK4 GCN2 KIAA1338 DHtsKKDPGGHRTAAILHGGsPDFVGNGKHRANSSGRSRRE
Q9P2K8 S467 Sugiyama EIF2AK4 GCN2 KIAA1338 SKRLADICKEDVFEQtRVRFsDNALPYKTGKKGDVWRLGLL
Q9P2K8 S572 Sugiyama EIF2AK4 GCN2 KIAA1338 PEDsEGQDYVETVIPSNRLPsAAFFSETQRQFSRYFIEFEE
Q9P2K8 T462 Sugiyama EIF2AK4 GCN2 KIAA1338 TDYSISKRLADICKEDVFEQtRVRFsDNALPYKTGKKGDVW
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.025047e-13 12.694 0 0
M Phase R-HSA-68886 2.275835e-11 10.643 0 0
Cell Cycle, Mitotic R-HSA-69278 3.908063e-11 10.408 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.532941e-11 10.123 0 0
Cell-Cell communication R-HSA-1500931 4.335341e-10 9.363 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.459944e-09 8.836 0 0
Cell Cycle Checkpoints R-HSA-69620 2.392975e-09 8.621 0 0
Mitotic Prometaphase R-HSA-68877 3.299100e-09 8.482 0 0
Axon guidance R-HSA-422475 3.135715e-09 8.504 0 0
Apoptotic execution phase R-HSA-75153 9.573906e-09 8.019 0 0
Cell junction organization R-HSA-446728 1.618480e-08 7.791 0 0
Nervous system development R-HSA-9675108 1.524104e-08 7.817 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.017565e-08 7.695 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.346541e-08 7.362 0 0
Recycling pathway of L1 R-HSA-437239 5.518250e-08 7.258 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 7.636813e-08 7.117 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.381418e-07 6.860 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.495899e-07 6.825 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.989769e-07 6.701 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.126885e-07 6.672 0 0
Mitotic Anaphase R-HSA-68882 2.667707e-07 6.574 0 0
L1CAM interactions R-HSA-373760 3.350317e-07 6.475 0 0
DNA Double Strand Break Response R-HSA-5693606 3.683405e-07 6.434 0 0
Separation of Sister Chromatids R-HSA-2467813 4.865730e-07 6.313 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 8.996715e-07 6.046 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 8.996715e-07 6.046 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.005493e-06 5.998 0 0
G2/M Checkpoints R-HSA-69481 1.057711e-06 5.976 0 0
Chromatin organization R-HSA-4839726 1.639211e-06 5.785 0 0
Mitotic Prophase R-HSA-68875 1.748457e-06 5.757 0 0
Cell-cell junction organization R-HSA-421270 2.055213e-06 5.687 0 0
Cellular Senescence R-HSA-2559583 2.341858e-06 5.630 0 0
Homology Directed Repair R-HSA-5693538 3.135268e-06 5.504 0 0
Nucleosome assembly R-HSA-774815 5.805830e-06 5.236 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.805830e-06 5.236 0 0
Signal Transduction R-HSA-162582 6.143998e-06 5.212 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.130200e-06 5.147 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.209113e-06 5.142 0 0
Amplification of signal from the kinetochores R-HSA-141424 7.926457e-06 5.101 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 7.926457e-06 5.101 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 8.188611e-06 5.087 0 0
Post NMDA receptor activation events R-HSA-438064 1.152654e-05 4.938 0 0
Adherens junctions interactions R-HSA-418990 1.354117e-05 4.868 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.769711e-05 4.752 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.136048e-05 4.670 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.136048e-05 4.670 0 0
Signaling by ERBB2 R-HSA-1227986 2.136048e-05 4.670 0 0
DNA Repair R-HSA-73894 2.189468e-05 4.660 0 0
Signaling by RAS mutants R-HSA-6802949 2.520068e-05 4.599 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.520068e-05 4.599 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.520068e-05 4.599 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.520068e-05 4.599 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.066819e-05 4.513 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.232220e-05 4.490 0 0
Chromatin modifying enzymes R-HSA-3247509 3.717003e-05 4.430 0 0
Meiotic synapsis R-HSA-1221632 4.129484e-05 4.384 0 0
Meiosis R-HSA-1500620 4.621637e-05 4.335 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.118318e-05 4.291 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.957756e-05 4.305 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.702573e-05 4.244 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.034220e-05 4.219 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.842310e-05 4.165 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.246158e-05 4.140 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.302566e-05 4.137 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.531574e-05 4.069 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.531574e-05 4.069 0 0
RAF activation R-HSA-5673000 1.132801e-04 3.946 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.132801e-04 3.946 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.218103e-04 3.914 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.396889e-04 3.855 0 0
Regulation of TP53 Activity R-HSA-5633007 1.438996e-04 3.842 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.532166e-04 3.815 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.621828e-04 3.790 0 0
ESR-mediated signaling R-HSA-8939211 1.700336e-04 3.769 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.787466e-04 3.748 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.787466e-04 3.748 0 0
SOS-mediated signalling R-HSA-112412 1.881977e-04 3.725 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.932662e-04 3.714 0 0
FLT3 Signaling R-HSA-9607240 1.932662e-04 3.714 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.902079e-04 3.721 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.943366e-04 3.711 0 0
EPH-Ephrin signaling R-HSA-2682334 1.949621e-04 3.710 0 0
Cellular responses to stimuli R-HSA-8953897 1.999962e-04 3.699 1 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.176876e-04 3.662 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.404991e-04 3.619 0 0
MAP2K and MAPK activation R-HSA-5674135 2.421124e-04 3.616 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.421124e-04 3.616 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.391735e-04 3.621 0 0
Meiotic recombination R-HSA-912446 2.316839e-04 3.635 0 0
Cellular responses to stress R-HSA-2262752 2.305821e-04 3.637 1 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.422680e-04 3.616 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.497498e-04 3.602 0 0
PECAM1 interactions R-HSA-210990 2.613352e-04 3.583 0 0
Regulation of CDH1 Function R-HSA-9764561 2.669988e-04 3.573 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.732328e-04 3.563 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.749950e-04 3.561 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.917268e-04 3.535 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.904149e-04 3.537 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.904149e-04 3.537 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.942071e-04 3.531 0 0
Signaling by Hippo R-HSA-2028269 2.904149e-04 3.537 0 0
Semaphorin interactions R-HSA-373755 2.984276e-04 3.525 0 0
Depurination R-HSA-73927 3.016322e-04 3.521 0 0
Signaling by NTRKs R-HSA-166520 3.051178e-04 3.516 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.211664e-04 3.493 0 0
G2/M Transition R-HSA-69275 3.253001e-04 3.488 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.554278e-04 3.449 0 0
Apoptosis R-HSA-109581 3.510036e-04 3.455 0 0
Programmed Cell Death R-HSA-5357801 3.376059e-04 3.472 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.940188e-04 3.404 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.001309e-04 3.398 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.292495e-04 3.367 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.093402e-04 3.388 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.292495e-04 3.367 0 0
Developmental Biology R-HSA-1266738 4.262864e-04 3.370 0 0
Deubiquitination R-HSA-5688426 4.452286e-04 3.351 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.703134e-04 3.328 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.975268e-04 3.303 0 0
Signaling by VEGF R-HSA-194138 5.509082e-04 3.259 0 0
Packaging Of Telomere Ends R-HSA-171306 5.547733e-04 3.256 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.910602e-04 3.228 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 6.236335e-04 3.205 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.476729e-04 3.189 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.901218e-04 3.161 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.138656e-04 3.146 0 0
Cleavage of the damaged purine R-HSA-110331 7.353422e-04 3.134 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.426410e-04 3.129 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.600602e-04 3.119 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.600602e-04 3.119 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.698244e-04 3.114 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.647456e-04 3.063 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 8.673200e-04 3.062 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.673200e-04 3.062 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.712677e-04 3.060 0 0
Depyrimidination R-HSA-73928 8.712677e-04 3.060 0 0
DNA methylation R-HSA-5334118 9.158727e-04 3.038 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.855479e-04 3.006 0 0
Gene expression (Transcription) R-HSA-74160 1.020516e-03 2.991 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.030145e-03 2.987 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.030145e-03 2.987 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.114361e-03 2.953 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.086463e-03 2.964 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.084360e-03 2.965 0 0
DAP12 signaling R-HSA-2424491 1.159441e-03 2.936 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.159441e-03 2.936 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.179936e-03 2.928 0 0
HDACs deacetylate histones R-HSA-3214815 1.282303e-03 2.892 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.294014e-03 2.888 0 0
Regulation of KIT signaling R-HSA-1433559 1.312885e-03 2.882 0 0
Aggrephagy R-HSA-9646399 1.358229e-03 2.867 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.358410e-03 2.867 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.358410e-03 2.867 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.377839e-03 2.861 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.530093e-03 2.815 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.742520e-03 2.759 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.683705e-03 2.774 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.586410e-03 2.800 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.755771e-03 2.756 0 0
Signaling by ALK in cancer R-HSA-9700206 1.755771e-03 2.756 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.766845e-03 2.753 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.767085e-03 2.753 0 0
Signaling by KIT in disease R-HSA-9669938 1.767085e-03 2.753 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.824954e-03 2.739 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.824954e-03 2.739 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.824954e-03 2.739 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.973129e-03 2.705 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.973129e-03 2.705 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.120592e-03 2.674 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.192465e-03 2.659 0 0
Selective autophagy R-HSA-9663891 2.446903e-03 2.611 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.230811e-03 2.652 0 0
Diseases of programmed cell death R-HSA-9645723 2.446903e-03 2.611 0 0
Chromosome Maintenance R-HSA-73886 2.488629e-03 2.604 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.519125e-03 2.599 0 0
MET activates RAS signaling R-HSA-8851805 2.813141e-03 2.551 0 0
Signaling by SCF-KIT R-HSA-1433557 2.822979e-03 2.549 0 0
MET activates PTPN11 R-HSA-8865999 2.838583e-03 2.547 0 0
RNA Polymerase I Transcription R-HSA-73864 2.846015e-03 2.546 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.847308e-03 2.546 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.847308e-03 2.546 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.888428e-03 2.539 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 2.910912e-03 2.536 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.105846e-03 2.508 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.259082e-03 2.487 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.343100e-03 2.476 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.353246e-03 2.475 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.439869e-03 2.463 0 0
Ub-specific processing proteases R-HSA-5689880 3.521909e-03 2.453 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.644314e-03 2.438 0 0
Nef and signal transduction R-HSA-164944 4.137136e-03 2.383 0 0
CREB phosphorylation R-HSA-199920 4.137136e-03 2.383 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.903169e-03 2.409 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.053284e-03 2.392 0 0
RNA Polymerase II Transcription R-HSA-73857 3.822966e-03 2.418 0 0
Signalling to ERKs R-HSA-187687 4.000964e-03 2.398 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.183314e-03 2.378 0 0
Centrosome maturation R-HSA-380287 4.204079e-03 2.376 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.215905e-03 2.375 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.278587e-03 2.369 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.278587e-03 2.369 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.410272e-03 2.356 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.496648e-03 2.347 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.365883e-03 2.360 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.755434e-03 2.323 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.818197e-03 2.317 0 0
GPVI-mediated activation cascade R-HSA-114604 4.794234e-03 2.319 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.875683e-03 2.312 0 0
MAPK family signaling cascades R-HSA-5683057 4.774766e-03 2.321 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.278587e-03 2.369 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.775547e-03 2.321 0 0
RUNX2 regulates bone development R-HSA-8941326 4.794234e-03 2.319 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.278587e-03 2.369 0 0
mRNA Splicing R-HSA-72172 4.910921e-03 2.309 0 0
Signal regulatory protein family interactions R-HSA-391160 5.286835e-03 2.277 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.382622e-03 2.269 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.382622e-03 2.269 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.534842e-03 2.257 0 0
Ephrin signaling R-HSA-3928664 5.706337e-03 2.244 0 0
Transport of connexons to the plasma membrane R-HSA-190872 5.706337e-03 2.244 0 0
Macroautophagy R-HSA-1632852 6.116547e-03 2.213 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.191237e-03 2.208 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.254687e-03 2.204 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.254687e-03 2.204 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.254687e-03 2.204 0 0
Co-stimulation by CD28 R-HSA-389356 6.261062e-03 2.203 0 0
Base Excision Repair R-HSA-73884 6.296198e-03 2.201 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.387131e-03 2.195 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.009198e-03 2.154 0 0
Erythropoietin activates RAS R-HSA-9027284 7.009198e-03 2.154 0 0
Regulation of signaling by CBL R-HSA-912631 7.273689e-03 2.138 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.273689e-03 2.138 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.128589e-03 2.147 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.979186e-03 2.156 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.854909e-03 2.164 0 0
Gap junction trafficking and regulation R-HSA-157858 7.241788e-03 2.140 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.751389e-03 2.171 0 0
Autophagy R-HSA-9612973 7.390856e-03 2.131 0 0
Kinesins R-HSA-983189 6.365973e-03 2.196 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 7.128589e-03 2.147 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.567337e-03 2.183 0 0
Reproduction R-HSA-1474165 6.944700e-03 2.158 0 0
Defective pyroptosis R-HSA-9710421 7.072709e-03 2.150 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.082874e-03 2.092 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.131807e-03 2.090 0 0
Signaling by NOTCH R-HSA-157118 8.151818e-03 2.089 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.165541e-03 2.088 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.340935e-03 2.079 0 0
Protein ubiquitination R-HSA-8852135 8.798520e-03 2.056 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.865602e-03 2.052 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.865602e-03 2.052 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.868543e-03 2.052 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.868543e-03 2.052 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 9.145249e-03 2.039 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 9.145249e-03 2.039 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 9.145249e-03 2.039 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 9.145249e-03 2.039 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 9.380402e-03 2.028 0 0
RSK activation R-HSA-444257 9.380402e-03 2.028 0 0
Formation of annular gap junctions R-HSA-196025 9.380402e-03 2.028 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.119720e-02 1.951 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.119720e-02 1.951 0 0
ERK/MAPK targets R-HSA-198753 1.135416e-02 1.945 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.066564e-02 1.972 0 0
mRNA 3'-end processing R-HSA-72187 1.093255e-02 1.961 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.093255e-02 1.961 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.082352e-02 1.966 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.045744e-02 1.981 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.030933e-02 1.987 0 0
HATs acetylate histones R-HSA-3214847 9.946327e-03 2.002 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.082352e-02 1.966 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.119720e-02 1.951 0 0
Diseases of DNA repair R-HSA-9675135 1.096348e-02 1.960 0 0
Interleukin-37 signaling R-HSA-9008059 9.797010e-03 2.009 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.139363e-02 1.943 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.139363e-02 1.943 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.139363e-02 1.943 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.139363e-02 1.943 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.139363e-02 1.943 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.139363e-02 1.943 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.139363e-02 1.943 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.139363e-02 1.943 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.139363e-02 1.943 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.139363e-02 1.943 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.139363e-02 1.943 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.139363e-02 1.943 0 0
Downstream signal transduction R-HSA-186763 1.166579e-02 1.933 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.224584e-02 1.912 0 0
Gap junction degradation R-HSA-190873 1.322064e-02 1.879 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.322064e-02 1.879 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.393331e-02 1.856 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.393331e-02 1.856 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.396755e-02 1.855 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.422890e-02 1.847 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.424263e-02 1.846 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.424263e-02 1.846 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.424263e-02 1.846 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.436436e-02 1.843 0 0
PKR-mediated signaling R-HSA-9833482 1.503474e-02 1.823 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.538009e-02 1.813 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.619562e-02 1.791 0 0
Integrin signaling R-HSA-354192 1.619562e-02 1.791 0 0
Degradation of CDH1 R-HSA-9766229 1.634166e-02 1.787 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.654755e-02 1.781 0 0
Signaling by FGFR4 R-HSA-5654743 1.656428e-02 1.781 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.686876e-02 1.773 0 0
Generic Transcription Pathway R-HSA-212436 1.735915e-02 1.760 0 0
HCMV Early Events R-HSA-9609690 1.778025e-02 1.750 0 0
Signaling by EGFR R-HSA-177929 1.796499e-02 1.746 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.800073e-02 1.745 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.800073e-02 1.745 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.253718e-02 1.647 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.253718e-02 1.647 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.253718e-02 1.647 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.253718e-02 1.647 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.253718e-02 1.647 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.253718e-02 1.647 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.824136e-02 1.739 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.047152e-02 1.689 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.833057e-02 1.737 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.889642e-02 1.724 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.032996e-02 1.692 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.837743e-02 1.736 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.191366e-02 1.659 0 0
Signaling by FGFR3 R-HSA-5654741 2.150248e-02 1.668 0 0
Gap junction trafficking R-HSA-190828 1.891325e-02 1.723 0 0
DAP12 interactions R-HSA-2172127 1.891325e-02 1.723 0 0
The NLRP3 inflammasome R-HSA-844456 2.227552e-02 1.652 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.881141e-02 1.726 0 0
Platelet sensitization by LDL R-HSA-432142 1.819099e-02 1.740 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.907323e-02 1.720 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.227552e-02 1.652 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.881141e-02 1.726 0 0
Co-inhibition by PD-1 R-HSA-389948 2.257321e-02 1.646 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.356867e-02 1.628 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.369636e-02 1.625 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.369636e-02 1.625 0 0
DCC mediated attractive signaling R-HSA-418885 2.369636e-02 1.625 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.369636e-02 1.625 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.380026e-02 1.623 0 0
Metabolism of RNA R-HSA-8953854 2.394976e-02 1.621 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.420793e-02 1.616 0 0
Neurodegenerative Diseases R-HSA-8863678 2.420793e-02 1.616 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.420793e-02 1.616 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.484151e-02 1.605 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.509154e-02 1.600 0 0
Oncogene Induced Senescence R-HSA-2559585 2.526596e-02 1.597 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.526596e-02 1.597 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.581025e-02 1.588 0 0
Smooth Muscle Contraction R-HSA-445355 2.636638e-02 1.579 0 0
Formation of definitive endoderm R-HSA-9823730 2.695373e-02 1.569 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.695373e-02 1.569 0 0
Signal transduction by L1 R-HSA-445144 2.695373e-02 1.569 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.799585e-02 1.553 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.835941e-02 1.547 0 0
Signaling by MET R-HSA-6806834 2.838669e-02 1.547 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.843789e-02 1.546 0 0
Tight junction interactions R-HSA-420029 2.857626e-02 1.544 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.857626e-02 1.544 0 0
FLT3 signaling in disease R-HSA-9682385 2.897111e-02 1.538 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.900550e-02 1.538 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.912511e-02 1.536 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.912511e-02 1.536 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.915870e-02 1.535 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.915870e-02 1.535 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.915870e-02 1.535 0 0
Prolonged ERK activation events R-HSA-169893 2.936525e-02 1.532 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.936525e-02 1.532 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.974665e-02 1.527 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.974665e-02 1.527 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.974665e-02 1.527 0 0
Signaling by ERBB4 R-HSA-1236394 3.029400e-02 1.519 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.045817e-02 1.516 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.068386e-02 1.513 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.068386e-02 1.513 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 3.068386e-02 1.513 0 0
Muscle contraction R-HSA-397014 3.091994e-02 1.510 0 0
MAP kinase activation R-HSA-450294 3.104525e-02 1.508 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.104525e-02 1.508 0 0
Regulation of gap junction activity R-HSA-191650 3.255917e-02 1.487 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 3.255917e-02 1.487 0 0
Signaling by MAP2K mutants R-HSA-9652169 3.255917e-02 1.487 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.346006e-02 1.475 0 0
Myogenesis R-HSA-525793 3.346006e-02 1.475 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.432973e-02 1.464 0 0
NCAM signaling for neurite out-growth R-HSA-375165 3.432973e-02 1.464 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.474032e-02 1.459 0 0
Membrane Trafficking R-HSA-199991 3.474642e-02 1.459 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 4.707211e-02 1.327 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 4.707211e-02 1.327 0 0
IKBKB deficiency causes SCID R-HSA-5602636 4.707211e-02 1.327 0 0
Type I hemidesmosome assembly R-HSA-446107 3.911807e-02 1.408 0 0
MET receptor recycling R-HSA-8875656 3.911807e-02 1.408 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.870011e-02 1.412 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.870011e-02 1.412 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.870011e-02 1.412 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.870011e-02 1.412 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.870011e-02 1.412 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.320609e-02 1.364 0 0
Notch-HLH transcription pathway R-HSA-350054 4.485819e-02 1.348 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.427661e-02 1.354 0 0
Repression of WNT target genes R-HSA-4641265 3.870011e-02 1.412 0 0
Telomere Maintenance R-HSA-157579 4.711489e-02 1.327 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.526470e-02 1.344 0 0
Cilium Assembly R-HSA-5617833 4.422963e-02 1.354 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.707211e-02 1.327 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.649211e-02 1.333 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.711489e-02 1.327 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.850975e-02 1.414 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.875994e-02 1.412 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.714252e-02 1.430 0 0
Activation of RAS in B cells R-HSA-1169092 3.911807e-02 1.408 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.911807e-02 1.408 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.870011e-02 1.412 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.850975e-02 1.414 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.785788e-02 1.422 0 0
Signaling by PTK6 R-HSA-8848021 3.785788e-02 1.422 0 0
Gene Silencing by RNA R-HSA-211000 3.750395e-02 1.426 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.070035e-02 1.390 0 0
IRE1alpha activates chaperones R-HSA-381070 4.725924e-02 1.326 0 0
Co-inhibition by BTLA R-HSA-9927353 4.761390e-02 1.322 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.788114e-02 1.320 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.788114e-02 1.320 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.788114e-02 1.320 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.788114e-02 1.320 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.789186e-02 1.320 0 0
Signaling by WNT R-HSA-195721 4.998289e-02 1.301 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.024771e-02 1.299 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.024771e-02 1.299 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.071532e-02 1.295 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.078720e-02 1.294 0 0
Regulated proteolysis of p75NTR R-HSA-193692 5.078720e-02 1.294 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.078720e-02 1.294 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.078720e-02 1.294 0 0
Unwinding of DNA R-HSA-176974 5.078720e-02 1.294 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.078720e-02 1.294 0 0
Signaling by Erythropoietin R-HSA-9006335 5.141340e-02 1.289 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.141340e-02 1.289 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.143299e-02 1.289 0 0
Tie2 Signaling R-HSA-210993 5.143299e-02 1.289 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 5.143299e-02 1.289 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.219584e-02 1.282 0 0
Growth hormone receptor signaling R-HSA-982772 5.219584e-02 1.282 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.456258e-02 1.263 0 0
Signaling by NOTCH4 R-HSA-9013694 5.504069e-02 1.259 0 0
Amyloid fiber formation R-HSA-977225 5.520942e-02 1.258 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.612619e-02 1.251 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.612619e-02 1.251 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.678695e-02 1.246 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.824275e-02 1.235 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.942082e-02 1.226 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.942082e-02 1.226 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.952175e-02 1.225 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.952175e-02 1.225 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.952175e-02 1.225 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.024539e-02 1.220 0 0
Signal attenuation R-HSA-74749 6.415234e-02 1.193 0 0
Signaling by Leptin R-HSA-2586552 6.415234e-02 1.193 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.548916e-02 1.184 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.548916e-02 1.184 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.548916e-02 1.184 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.548916e-02 1.184 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.548916e-02 1.184 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.570043e-02 1.182 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.602776e-02 1.180 0 0
Toll-like Receptor Cascades R-HSA-168898 6.781717e-02 1.169 0 0
TGFBR3 expression R-HSA-9839394 6.901521e-02 1.161 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.901521e-02 1.161 0 0
Signaling by FGFR1 R-HSA-5654736 6.922892e-02 1.160 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.922892e-02 1.160 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.978486e-02 1.156 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.978486e-02 1.156 0 0
p38MAPK events R-HSA-171007 6.978486e-02 1.156 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.978486e-02 1.156 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.978486e-02 1.156 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.999463e-02 1.155 0 0
Interleukin-17 signaling R-HSA-448424 6.999463e-02 1.155 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.002369e-02 1.155 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 7.057229e-02 1.151 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.141419e-02 1.146 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.141419e-02 1.146 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.250270e-02 1.140 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.462403e-02 1.127 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.462403e-02 1.127 0 0
Signaling by WNT in cancer R-HSA-4791275 7.462403e-02 1.127 0 0
MHC class II antigen presentation R-HSA-2132295 7.571516e-02 1.121 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.571516e-02 1.121 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.082027e-01 0.966 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.082027e-01 0.966 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.082027e-01 0.966 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.082027e-01 0.966 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 1.082027e-01 0.966 0 0
Defective OGG1 Localization R-HSA-9657050 1.082027e-01 0.966 0 0
Regulation of TP53 Expression R-HSA-6804754 7.774113e-02 1.109 0 0
Axonal growth stimulation R-HSA-209563 1.129310e-01 0.947 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.129310e-01 0.947 0 0
MET interacts with TNS proteins R-HSA-8875513 1.129310e-01 0.947 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.129310e-01 0.947 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.596675e-02 1.066 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 8.596675e-02 1.066 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 8.596675e-02 1.066 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.087813e-01 0.963 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.087813e-01 0.963 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.087813e-01 0.963 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.087813e-01 0.963 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.916835e-02 1.101 0 0
Signaling by APC mutants R-HSA-4839744 7.916835e-02 1.101 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.916835e-02 1.101 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.916835e-02 1.101 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.916835e-02 1.101 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 9.576322e-02 1.019 0 0
ERKs are inactivated R-HSA-202670 9.576322e-02 1.019 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.249246e-02 1.084 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.249246e-02 1.084 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.138427e-01 0.944 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.872211e-02 1.052 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.964925e-02 1.002 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.964925e-02 1.002 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.356433e-02 1.078 0 0
MET promotes cell motility R-HSA-8875878 7.826231e-02 1.106 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.112771e-01 0.954 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.559929e-02 1.020 0 0
Metabolism of non-coding RNA R-HSA-194441 8.929569e-02 1.049 0 0
snRNP Assembly R-HSA-191859 8.929569e-02 1.049 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.057518e-01 0.976 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.328843e-02 1.030 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.148772e-02 1.089 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 1.112761e-01 0.954 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.414466e-02 1.075 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.872211e-02 1.052 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.044744e-01 0.981 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.027402e-01 0.988 0 0
Mitophagy R-HSA-5205647 1.032465e-01 0.986 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.138427e-01 0.944 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.112761e-01 0.954 0 0
Signaling by NOTCH3 R-HSA-9012852 1.140054e-01 0.943 0 0
Signaling by FGFR2 R-HSA-5654738 8.696023e-02 1.061 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.356433e-02 1.078 0 0
Adaptive Immune System R-HSA-1280218 9.171556e-02 1.038 0 0
S Phase R-HSA-69242 1.060035e-01 0.975 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.050396e-01 0.979 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.850823e-02 1.105 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.112771e-01 0.954 0 0
Signalling to RAS R-HSA-167044 8.148772e-02 1.089 0 0
Signaling by NOTCH1 R-HSA-1980143 1.088033e-01 0.963 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 8.356433e-02 1.078 0 0
Host Interactions of HIV factors R-HSA-162909 8.018791e-02 1.096 0 0
Gap junction assembly R-HSA-190861 1.032465e-01 0.986 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.328843e-02 1.030 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 1.059556e-01 0.975 0 0
Gastrulation R-HSA-9758941 1.111432e-01 0.954 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.015876e-01 0.993 0 0
Signaling by AMER1 mutants R-HSA-4839748 9.576322e-02 1.019 0 0
Signaling by AXIN mutants R-HSA-4839735 9.576322e-02 1.019 0 0
Netrin-1 signaling R-HSA-373752 8.050739e-02 1.094 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.574511e-02 1.019 0 0
Signaling by TGFBR3 R-HSA-9839373 9.679377e-02 1.014 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.140054e-01 0.943 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.303645e-02 1.031 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.087813e-01 0.963 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 9.618616e-02 1.017 0 0
Inflammasomes R-HSA-622312 9.964925e-02 1.002 0 0
SARS-CoV-1-host interactions R-HSA-9692914 9.143055e-02 1.039 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 9.362900e-02 1.029 0 0
Signaling by PDGFR in disease R-HSA-9671555 9.328843e-02 1.030 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.141331e-01 0.943 0 0
Signaling by ROBO receptors R-HSA-376176 1.147400e-01 0.940 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.182709e-01 0.927 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.188049e-01 0.925 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.188049e-01 0.925 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.202662e-01 0.920 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.210694e-01 0.917 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.217117e-01 0.915 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.218851e-01 0.914 0 0
Ion homeostasis R-HSA-5578775 1.230630e-01 0.910 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.235882e-01 0.908 0 0
Activation of the pre-replicative complex R-HSA-68962 1.235882e-01 0.908 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.235882e-01 0.908 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.241277e-01 0.906 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.248434e-01 0.904 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.254344e-01 0.902 0 0
MTOR signalling R-HSA-165159 1.254344e-01 0.902 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.272584e-01 0.895 0 0
GAB1 signalosome R-HSA-180292 1.272584e-01 0.895 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.272584e-01 0.895 0 0
Signaling by TGFB family members R-HSA-9006936 1.288383e-01 0.890 0 0
Insulin receptor signalling cascade R-HSA-74751 1.299241e-01 0.886 0 0
IGF1R signaling cascade R-HSA-2428924 1.299241e-01 0.886 0 0
Sensory processing of sound R-HSA-9659379 1.322318e-01 0.879 0 0
IRS-mediated signalling R-HSA-112399 1.325088e-01 0.878 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.326398e-01 0.877 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.326398e-01 0.877 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.326398e-01 0.877 0 0
G1/S Transition R-HSA-69206 1.326398e-01 0.877 0 0
DNA Replication R-HSA-69306 1.332423e-01 0.875 0 0
Frs2-mediated activation R-HSA-170968 1.332946e-01 0.875 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 1.336396e-01 0.874 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 1.336396e-01 0.874 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.336396e-01 0.874 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.336396e-01 0.874 0 0
Adrenoceptors R-HSA-390696 1.336396e-01 0.874 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.337784e-01 0.874 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.357139e-01 0.867 0 0
PTEN Regulation R-HSA-6807070 1.363206e-01 0.865 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.387196e-01 0.858 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.391076e-01 0.857 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.391076e-01 0.857 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.416924e-01 0.849 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.442595e-01 0.841 0 0
Long-term potentiation R-HSA-9620244 1.488626e-01 0.827 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 1.488626e-01 0.827 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.513053e-01 0.820 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.513053e-01 0.820 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.513053e-01 0.820 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.513053e-01 0.820 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.513053e-01 0.820 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 1.513053e-01 0.820 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.514488e-01 0.820 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.539935e-01 0.812 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.539935e-01 0.812 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.539935e-01 0.812 0 0
HCMV Infection R-HSA-9609646 1.555546e-01 0.808 0 0
Neurexins and neuroligins R-HSA-6794361 1.562569e-01 0.806 0 0
ARMS-mediated activation R-HSA-170984 1.602356e-01 0.795 0 0
MAPK1 (ERK2) activation R-HSA-112411 1.602356e-01 0.795 0 0
ALK mutants bind TKIs R-HSA-9700645 1.602356e-01 0.795 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.624869e-01 0.789 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.624869e-01 0.789 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.630974e-01 0.788 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.630974e-01 0.788 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.630974e-01 0.788 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.630974e-01 0.788 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.630974e-01 0.788 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.643825e-01 0.784 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.643825e-01 0.784 0 0
Nuclear RNA decay R-HSA-9930044 1.643825e-01 0.784 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.643825e-01 0.784 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.643825e-01 0.784 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.047032e-01 0.689 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 2.047032e-01 0.689 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.047032e-01 0.689 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.047032e-01 0.689 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.047032e-01 0.689 0 0
Defective MOGS causes CDG-2b R-HSA-4793954 2.047032e-01 0.689 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.047032e-01 0.689 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.047032e-01 0.689 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.047032e-01 0.689 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.047032e-01 0.689 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 2.907665e-01 0.536 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.907665e-01 0.536 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.907665e-01 0.536 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.907665e-01 0.536 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.907665e-01 0.536 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.907665e-01 0.536 0 0
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-5619099 2.907665e-01 0.536 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.907665e-01 0.536 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.907665e-01 0.536 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.907665e-01 0.536 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 2.907665e-01 0.536 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.907665e-01 0.536 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.907665e-01 0.536 0 0
Reelin signalling pathway R-HSA-8866376 1.917639e-01 0.717 0 0
IRS activation R-HSA-74713 1.917639e-01 0.717 0 0
NTRK2 activates RAC1 R-HSA-9032759 1.917639e-01 0.717 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.917639e-01 0.717 0 0
Phosphorylation of Emi1 R-HSA-176417 2.334071e-01 0.632 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 2.334071e-01 0.632 0 0
Signaling by MAPK mutants R-HSA-9652817 2.334071e-01 0.632 0 0
Signaling by RNF43 mutants R-HSA-5340588 2.334071e-01 0.632 0 0
2-LTR circle formation R-HSA-164843 1.882620e-01 0.725 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.755053e-01 0.560 0 0
STAT5 Activation R-HSA-9645135 2.755053e-01 0.560 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.174189e-01 0.663 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.174189e-01 0.663 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.758042e-01 0.755 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.474194e-01 0.607 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.474194e-01 0.607 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.174728e-01 0.498 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.174728e-01 0.498 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.174728e-01 0.498 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.221932e-01 0.653 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.221932e-01 0.653 0 0
Disorders of Developmental Biology R-HSA-9675151 2.221932e-01 0.653 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.779950e-01 0.556 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.779950e-01 0.556 0 0
Pervasive developmental disorders R-HSA-9005895 2.779950e-01 0.556 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.779950e-01 0.556 0 0
Disorders of Nervous System Development R-HSA-9697154 2.779950e-01 0.556 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.002669e-01 0.698 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.203976e-01 0.657 0 0
Striated Muscle Contraction R-HSA-390522 1.791688e-01 0.747 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.791688e-01 0.747 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.944917e-01 0.711 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.759171e-01 0.755 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.341325e-01 0.631 0 0
RET signaling R-HSA-8853659 2.265903e-01 0.645 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.265903e-01 0.645 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.527721e-01 0.597 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.527721e-01 0.597 0 0
Negative regulation of MET activity R-HSA-6807004 3.220432e-01 0.492 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.432830e-01 0.614 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.718024e-01 0.566 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.058555e-01 0.514 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.911624e-01 0.536 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.280182e-01 0.484 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.280182e-01 0.484 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.801093e-01 0.744 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.539524e-01 0.595 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.107914e-01 0.508 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.954074e-01 0.530 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.954074e-01 0.530 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.814794e-01 0.551 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.687410e-01 0.571 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.978215e-01 0.526 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.214344e-01 0.655 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.144936e-01 0.502 0 0
Neutrophil degranulation R-HSA-6798695 2.973463e-01 0.527 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.905828e-01 0.537 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.944917e-01 0.711 0 0
RNA Polymerase III Transcription R-HSA-74158 2.265903e-01 0.645 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.847014e-01 0.734 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.203976e-01 0.657 0 0
p75NTR signals via NF-kB R-HSA-193639 1.758042e-01 0.755 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.985855e-01 0.702 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 2.474194e-01 0.607 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.240656e-01 0.650 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.144936e-01 0.502 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 3.088975e-01 0.510 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.653844e-01 0.576 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.011736e-01 0.696 0 0
Integration of provirus R-HSA-162592 2.474194e-01 0.607 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.539524e-01 0.595 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 3.293486e-01 0.482 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.175267e-01 0.662 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.713124e-01 0.567 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.246044e-01 0.489 0 0
Developmental Cell Lineages R-HSA-9734767 2.850025e-01 0.545 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.295493e-01 0.639 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.246044e-01 0.489 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.917639e-01 0.717 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 2.334071e-01 0.632 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.334071e-01 0.632 0 0
Regulation of CDH11 function R-HSA-9762292 1.882620e-01 0.725 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.174728e-01 0.498 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.174728e-01 0.498 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.058555e-01 0.514 0 0
Stabilization of p53 R-HSA-69541 2.777364e-01 0.556 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.713124e-01 0.567 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.432830e-01 0.614 0 0
Protein folding R-HSA-391251 2.847815e-01 0.545 0 0
Killing mechanisms R-HSA-9664420 1.985855e-01 0.702 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 1.985855e-01 0.702 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.113600e-01 0.675 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.280182e-01 0.484 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.311053e-01 0.480 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.311053e-01 0.480 0 0
RAS processing R-HSA-9648002 2.777364e-01 0.556 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.010561e-01 0.697 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.758042e-01 0.755 0 0
NF-kB is activated and signals survival R-HSA-209560 2.474194e-01 0.607 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.221932e-01 0.653 0 0
Translesion Synthesis by POLH R-HSA-110320 2.965434e-01 0.528 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.968429e-01 0.706 0 0
DNA strand elongation R-HSA-69190 2.718024e-01 0.566 0 0
Heme signaling R-HSA-9707616 1.852642e-01 0.732 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.159440e-01 0.666 0 0
Nuclear import of Rev protein R-HSA-180746 1.944917e-01 0.711 0 0
NRAGE signals death through JNK R-HSA-193648 3.144936e-01 0.502 0 0
PCP/CE pathway R-HSA-4086400 2.857397e-01 0.544 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.777364e-01 0.556 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.527721e-01 0.597 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.130154e-01 0.504 0 0
Signaling by PDGF R-HSA-186797 2.850832e-01 0.545 0 0
Cellular response to chemical stress R-HSA-9711123 2.103838e-01 0.677 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 2.907665e-01 0.536 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.334071e-01 0.632 0 0
VLDL clearance R-HSA-8964046 3.174728e-01 0.498 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.987267e-01 0.702 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.249560e-01 0.488 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.911624e-01 0.536 0 0
HIV Infection R-HSA-162906 2.088750e-01 0.680 0 0
Signaling by Insulin receptor R-HSA-74752 2.847815e-01 0.545 0 0
Nephrin family interactions R-HSA-373753 3.220432e-01 0.492 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 2.103124e-01 0.677 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.174189e-01 0.663 0 0
G alpha (12/13) signalling events R-HSA-416482 2.857397e-01 0.544 0 0
Death Receptor Signaling R-HSA-73887 2.554702e-01 0.593 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.740112e-01 0.759 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.103124e-01 0.677 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.898201e-01 0.722 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.474973e-01 0.606 0 0
Somitogenesis R-HSA-9824272 2.653844e-01 0.576 0 0
Diseases of Immune System R-HSA-5260271 2.954074e-01 0.530 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.954074e-01 0.530 0 0
Signaling by FGFR R-HSA-190236 2.727094e-01 0.564 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 1.982662e-01 0.703 0 0
Inhibition of PKR R-HSA-169131 2.047032e-01 0.689 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.907665e-01 0.536 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.334071e-01 0.632 0 0
Proton/oligopeptide cotransporters R-HSA-427975 2.334071e-01 0.632 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.174728e-01 0.498 0 0
Netrin mediated repulsion signals R-HSA-418886 3.174728e-01 0.498 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.174728e-01 0.498 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 1.808047e-01 0.743 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.779950e-01 0.556 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.002669e-01 0.698 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 2.002669e-01 0.698 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.759171e-01 0.755 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 2.623153e-01 0.581 0 0
Signaling by NODAL R-HSA-1181150 3.220432e-01 0.492 0 0
Metalloprotease DUBs R-HSA-5689901 3.058555e-01 0.514 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 3.280182e-01 0.484 0 0
Orc1 removal from chromatin R-HSA-68949 2.539524e-01 0.595 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.954074e-01 0.530 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.954074e-01 0.530 0 0
Signaling by NOTCH2 R-HSA-1980145 3.306293e-01 0.481 0 0
Intraflagellar transport R-HSA-5620924 3.143753e-01 0.503 0 0
TCR signaling R-HSA-202403 2.408732e-01 0.618 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.269161e-01 0.486 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.066112e-01 0.513 0 0
Interferon Signaling R-HSA-913531 2.594335e-01 0.586 0 0
Cardiogenesis R-HSA-9733709 2.911624e-01 0.536 0 0
Suppression of apoptosis R-HSA-9635465 2.174189e-01 0.663 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.058555e-01 0.514 0 0
Signaling by FGFR in disease R-HSA-1226099 2.359561e-01 0.627 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.603465e-01 0.584 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.947253e-01 0.531 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.539524e-01 0.595 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.107914e-01 0.508 0 0
Platelet calcium homeostasis R-HSA-418360 2.159440e-01 0.666 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.432830e-01 0.614 0 0
Interleukin-1 family signaling R-HSA-446652 1.772007e-01 0.752 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.907665e-01 0.536 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.917639e-01 0.717 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 3.174728e-01 0.498 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.779950e-01 0.556 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.829514e-01 0.548 0 0
Activation of BH3-only proteins R-HSA-114452 2.341325e-01 0.631 0 0
Hedgehog 'off' state R-HSA-5610787 2.952723e-01 0.530 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.087327e-01 0.680 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.603465e-01 0.584 0 0
Generation of second messenger molecules R-HSA-202433 2.954074e-01 0.530 0 0
Neurofascin interactions R-HSA-447043 2.755053e-01 0.560 0 0
Regulation of beta-cell development R-HSA-186712 2.433178e-01 0.614 0 0
Diseases of Base Excision Repair R-HSA-9605308 2.334071e-01 0.632 0 0
Interleukin-2 signaling R-HSA-9020558 2.174189e-01 0.663 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.907665e-01 0.536 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.917639e-01 0.717 0 0
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells R-HSA-210746 2.755053e-01 0.560 0 0
Signaling by FGFR3 in disease R-HSA-5655332 1.811570e-01 0.742 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.144936e-01 0.502 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.917639e-01 0.717 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.174728e-01 0.498 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.360545e-01 0.627 0 0
Interleukin-12 signaling R-HSA-9020591 1.732386e-01 0.761 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.041676e-01 0.690 0 0
Interleukin-12 family signaling R-HSA-447115 3.102329e-01 0.508 0 0
Prolactin receptor signaling R-HSA-1170546 3.399011e-01 0.469 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.399011e-01 0.469 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.399011e-01 0.469 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.399011e-01 0.469 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.409433e-01 0.467 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.419157e-01 0.466 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.424402e-01 0.465 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.451490e-01 0.462 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.476858e-01 0.459 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.476858e-01 0.459 0 0
Downstream TCR signaling R-HSA-202424 3.484262e-01 0.458 0 0
HIV elongation arrest and recovery R-HSA-167287 3.503319e-01 0.456 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.503319e-01 0.456 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 3.503319e-01 0.456 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.506171e-01 0.455 0 0
PERK regulates gene expression R-HSA-381042 3.506171e-01 0.455 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.550767e-01 0.450 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.588453e-01 0.445 0 0
phospho-PLA2 pathway R-HSA-111995 3.588453e-01 0.445 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.588453e-01 0.445 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.588453e-01 0.445 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.588453e-01 0.445 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.588453e-01 0.445 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.588453e-01 0.445 0 0
Neuronal System R-HSA-112316 3.600102e-01 0.444 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.675210e-01 0.435 0 0
Signalling to ERK5 R-HSA-198765 3.675210e-01 0.435 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.675210e-01 0.435 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.675210e-01 0.435 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.675210e-01 0.435 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 3.675210e-01 0.435 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.675210e-01 0.435 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.675210e-01 0.435 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.675210e-01 0.435 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.675210e-01 0.435 0 0
rRNA processing R-HSA-72312 3.686098e-01 0.433 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.690031e-01 0.433 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.706975e-01 0.431 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.708030e-01 0.431 0 0
Translesion synthesis by REV1 R-HSA-110312 3.708030e-01 0.431 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 3.708030e-01 0.431 0 0
Other semaphorin interactions R-HSA-416700 3.708030e-01 0.431 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.708030e-01 0.431 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.708030e-01 0.431 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.733532e-01 0.428 0 0
Platelet homeostasis R-HSA-418346 3.778542e-01 0.423 0 0
FOXO-mediated transcription R-HSA-9614085 3.825270e-01 0.417 0 0
Proteasome assembly R-HSA-9907900 3.864042e-01 0.413 0 0
G1 Phase R-HSA-69236 3.864042e-01 0.413 0 0
Cyclin D associated events in G1 R-HSA-69231 3.864042e-01 0.413 0 0
Vesicle-mediated transport R-HSA-5653656 3.877180e-01 0.411 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.885018e-01 0.411 0 0
Degradation of DVL R-HSA-4641258 3.908149e-01 0.408 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.951000e-01 0.403 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.951000e-01 0.403 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.951000e-01 0.403 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.989355e-01 0.399 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.989355e-01 0.399 0 0
mTORC1-mediated signalling R-HSA-166208 3.989355e-01 0.399 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.989355e-01 0.399 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.990888e-01 0.399 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.992603e-01 0.399 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.992603e-01 0.399 0 0
WNT mediated activation of DVL R-HSA-201688 3.992603e-01 0.399 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.992603e-01 0.399 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 3.992603e-01 0.399 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.992603e-01 0.399 0 0
Calcineurin activates NFAT R-HSA-2025928 3.992603e-01 0.399 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.992603e-01 0.399 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.992603e-01 0.399 0 0
Interleukin-1 processing R-HSA-448706 3.992603e-01 0.399 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.992603e-01 0.399 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.992603e-01 0.399 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 4.014236e-01 0.396 0 0
Translesion synthesis by POLI R-HSA-5656121 4.014236e-01 0.396 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.014236e-01 0.396 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.014236e-01 0.396 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.020883e-01 0.396 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.048258e-01 0.393 0 0
Interleukin-1 signaling R-HSA-9020702 4.077040e-01 0.390 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.109161e-01 0.386 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.139103e-01 0.383 0 0
Signaling by Hedgehog R-HSA-5358351 4.142072e-01 0.383 0 0
Translation initiation complex formation R-HSA-72649 4.161809e-01 0.381 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.174078e-01 0.379 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.187347e-01 0.378 0 0
Adipogenesis R-HSA-9843745 4.198647e-01 0.377 0 0
Cardiac conduction R-HSA-5576891 4.198647e-01 0.377 0 0
Signaling by Interleukins R-HSA-449147 4.213254e-01 0.375 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.232246e-01 0.373 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.232246e-01 0.373 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.232246e-01 0.373 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.232246e-01 0.373 0 0
Syndecan interactions R-HSA-3000170 4.243319e-01 0.372 0 0
Circadian clock R-HSA-9909396 4.309367e-01 0.366 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.309503e-01 0.366 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.316058e-01 0.365 0 0
Translesion synthesis by POLK R-HSA-5655862 4.316058e-01 0.365 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 4.316058e-01 0.365 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.316058e-01 0.365 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.316058e-01 0.365 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.338503e-01 0.363 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 4.359729e-01 0.361 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.359729e-01 0.361 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.359729e-01 0.361 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 4.359729e-01 0.361 0 0
Invadopodia formation R-HSA-8941237 4.359729e-01 0.361 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 4.359729e-01 0.361 0 0
Classical Kir channels R-HSA-1296053 4.359729e-01 0.361 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.359729e-01 0.361 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 4.359729e-01 0.361 0 0
MET activates STAT3 R-HSA-8875791 4.359729e-01 0.361 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.359729e-01 0.361 0 0
Histamine receptors R-HSA-390650 4.359729e-01 0.361 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.384406e-01 0.358 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.384406e-01 0.358 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.384406e-01 0.358 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.384406e-01 0.358 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.384406e-01 0.358 0 0
PI3K/AKT activation R-HSA-198203 4.384406e-01 0.358 0 0
Josephin domain DUBs R-HSA-5689877 4.384406e-01 0.358 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.384406e-01 0.358 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.384406e-01 0.358 0 0
Formation of apoptosome R-HSA-111458 4.384406e-01 0.358 0 0
Maturation of spike protein R-HSA-9683686 4.384406e-01 0.358 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.384406e-01 0.358 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.399063e-01 0.357 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.399063e-01 0.357 0 0
Ion transport by P-type ATPases R-HSA-936837 4.416748e-01 0.355 0 0
ER-Phagosome pathway R-HSA-1236974 4.473267e-01 0.349 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.494505e-01 0.347 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 4.494505e-01 0.347 0 0
Deadenylation of mRNA R-HSA-429947 4.494505e-01 0.347 0 0
TNF signaling R-HSA-75893 4.502551e-01 0.347 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.508694e-01 0.346 0 0
Interleukin-2 family signaling R-HSA-451927 4.508694e-01 0.346 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.522308e-01 0.345 0 0
Viral Infection Pathways R-HSA-9824446 4.574464e-01 0.340 0 0
NGF-stimulated transcription R-HSA-9031628 4.598011e-01 0.337 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.612141e-01 0.336 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 4.612141e-01 0.336 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.612141e-01 0.336 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 4.612141e-01 0.336 0 0
SARS-CoV Infections R-HSA-9679506 4.652918e-01 0.332 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.671774e-01 0.331 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.706282e-01 0.327 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.706282e-01 0.327 0 0
Nucleotide Excision Repair R-HSA-5696398 4.707826e-01 0.327 0 0
HDMs demethylate histones R-HSA-3214842 4.742086e-01 0.324 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.746102e-01 0.324 0 0
Formation of the posterior neural plate R-HSA-9832991 4.761802e-01 0.322 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.761802e-01 0.322 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.761802e-01 0.322 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.761802e-01 0.322 0 0
DNA Damage Bypass R-HSA-73893 4.779071e-01 0.321 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.789367e-01 0.320 0 0
Cellular response to heat stress R-HSA-3371556 4.790403e-01 0.320 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.821075e-01 0.317 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.832427e-01 0.316 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.832427e-01 0.316 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.832427e-01 0.316 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.839852e-01 0.315 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.901338e-01 0.310 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.901338e-01 0.310 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.901338e-01 0.310 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.901338e-01 0.310 0 0
Apoptotic factor-mediated response R-HSA-111471 4.901338e-01 0.310 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.901844e-01 0.310 0 0
UCH proteinases R-HSA-5689603 4.938113e-01 0.306 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.958046e-01 0.305 0 0
PI3K Cascade R-HSA-109704 4.958470e-01 0.305 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.958470e-01 0.305 0 0
NADE modulates death signalling R-HSA-205025 4.970201e-01 0.304 0 0
Nucleotide catabolism defects R-HSA-9735786 4.970201e-01 0.304 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 4.970201e-01 0.304 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.970201e-01 0.304 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.970201e-01 0.304 0 0
Signaling by LRP5 mutants R-HSA-5339717 4.970201e-01 0.304 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.970201e-01 0.304 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.970201e-01 0.304 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.970201e-01 0.304 0 0
Vasopressin-like receptors R-HSA-388479 4.970201e-01 0.304 0 0
ATP sensitive Potassium channels R-HSA-1296025 4.970201e-01 0.304 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.970201e-01 0.304 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.970201e-01 0.304 0 0
Dopamine receptors R-HSA-390651 4.970201e-01 0.304 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.979234e-01 0.303 0 0
MET activates PTK2 signaling R-HSA-8874081 4.985326e-01 0.302 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.046350e-01 0.297 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.046350e-01 0.297 0 0
Regulated Necrosis R-HSA-5218859 5.048443e-01 0.297 0 0
Glycolysis R-HSA-70171 5.050661e-01 0.297 0 0
Ribosome-associated quality control R-HSA-9948299 5.080977e-01 0.294 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.082234e-01 0.294 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.094988e-01 0.293 0 0
Ca-dependent events R-HSA-111996 5.094988e-01 0.293 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.123321e-01 0.290 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.123321e-01 0.290 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.123321e-01 0.290 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.123321e-01 0.290 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 5.123321e-01 0.290 0 0
Activation of RAC1 R-HSA-428540 5.123321e-01 0.290 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.123321e-01 0.290 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.123321e-01 0.290 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.132454e-01 0.290 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.135901e-01 0.289 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.135901e-01 0.289 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 5.182691e-01 0.285 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.182691e-01 0.285 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.182691e-01 0.285 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.182691e-01 0.285 0 0
Rap1 signalling R-HSA-392517 5.182691e-01 0.285 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 5.182691e-01 0.285 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 5.182691e-01 0.285 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.223578e-01 0.282 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.223578e-01 0.282 0 0
Integrin cell surface interactions R-HSA-216083 5.232163e-01 0.281 0 0
Regulation of Apoptosis R-HSA-169911 5.256683e-01 0.279 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.258695e-01 0.279 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 5.285355e-01 0.277 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.285355e-01 0.277 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.311076e-01 0.275 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.356552e-01 0.271 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.377120e-01 0.269 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.455420e-01 0.263 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 5.455420e-01 0.263 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.455420e-01 0.263 0 0
HSF1 activation R-HSA-3371511 5.463006e-01 0.263 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.467979e-01 0.262 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.467979e-01 0.262 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.467979e-01 0.262 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.467979e-01 0.262 0 0
Signaling by LTK R-HSA-9842663 5.467979e-01 0.262 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 5.467979e-01 0.262 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.467979e-01 0.262 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.467979e-01 0.262 0 0
Regulation of IFNG signaling R-HSA-877312 5.467979e-01 0.262 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.467979e-01 0.262 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 5.472614e-01 0.262 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.483729e-01 0.261 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.483729e-01 0.261 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.495644e-01 0.260 0 0
tRNA processing in the nucleus R-HSA-6784531 5.495644e-01 0.260 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.507971e-01 0.259 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.507971e-01 0.259 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.514630e-01 0.258 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.514630e-01 0.258 0 0
NrCAM interactions R-HSA-447038 5.514630e-01 0.258 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.514630e-01 0.258 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.514630e-01 0.258 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.514630e-01 0.258 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.514630e-01 0.258 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.514630e-01 0.258 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.514630e-01 0.258 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.514630e-01 0.258 0 0
Activation of AKT2 R-HSA-165158 5.514630e-01 0.258 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.514630e-01 0.258 0 0
Suppression of autophagy R-HSA-9636569 5.514630e-01 0.258 0 0
Inositol transporters R-HSA-429593 5.514630e-01 0.258 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.514630e-01 0.258 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.514630e-01 0.258 0 0
Peptide chain elongation R-HSA-156902 5.533043e-01 0.257 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.570318e-01 0.254 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.570318e-01 0.254 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.653617e-01 0.248 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.654324e-01 0.248 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.654324e-01 0.248 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.656470e-01 0.247 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.656470e-01 0.247 0 0
Degradation of AXIN R-HSA-4641257 5.664946e-01 0.247 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.664946e-01 0.247 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.664946e-01 0.247 0 0
DARPP-32 events R-HSA-180024 5.682951e-01 0.245 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.718908e-01 0.243 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.718908e-01 0.243 0 0
Basigin interactions R-HSA-210991 5.718908e-01 0.243 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.795192e-01 0.237 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.795192e-01 0.237 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.795192e-01 0.237 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.795192e-01 0.237 0 0
Formation of axial mesoderm R-HSA-9796292 5.795192e-01 0.237 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.795192e-01 0.237 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.795192e-01 0.237 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.795192e-01 0.237 0 0
Interleukin-6 signaling R-HSA-1059683 5.795192e-01 0.237 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.795192e-01 0.237 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.836654e-01 0.234 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.836654e-01 0.234 0 0
Influenza Infection R-HSA-168255 5.852285e-01 0.233 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.903192e-01 0.229 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.928182e-01 0.227 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.939554e-01 0.226 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.972682e-01 0.224 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 5.972682e-01 0.224 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.000158e-01 0.222 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.000158e-01 0.222 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.000158e-01 0.222 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.000158e-01 0.222 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.000158e-01 0.222 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.000158e-01 0.222 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 6.000158e-01 0.222 0 0
PDE3B signalling R-HSA-165160 6.000158e-01 0.222 0 0
Synthesis of PS R-HSA-1483101 6.000158e-01 0.222 0 0
PKB-mediated events R-HSA-109703 6.000158e-01 0.222 0 0
Ceramide signalling R-HSA-193681 6.000158e-01 0.222 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.000158e-01 0.222 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.000158e-01 0.222 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.000158e-01 0.222 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.000158e-01 0.222 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.000158e-01 0.222 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.000158e-01 0.222 0 0
Transmission across Chemical Synapses R-HSA-112315 6.036800e-01 0.219 0 0
Synthesis of DNA R-HSA-69239 6.045175e-01 0.219 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.054419e-01 0.218 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.054419e-01 0.218 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.062206e-01 0.217 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.075137e-01 0.216 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.092171e-01 0.215 0 0
Removal of the Flap Intermediate R-HSA-69166 6.104696e-01 0.214 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.104696e-01 0.214 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.104696e-01 0.214 0 0
cGMP effects R-HSA-418457 6.104696e-01 0.214 0 0
EGFR downregulation R-HSA-182971 6.116674e-01 0.213 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.189763e-01 0.208 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.216404e-01 0.206 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.216404e-01 0.206 0 0
FGFR2 alternative splicing R-HSA-6803529 6.216404e-01 0.206 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.216404e-01 0.206 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.216404e-01 0.206 0 0
HIV Life Cycle R-HSA-162587 6.228634e-01 0.206 0 0
Leishmania phagocytosis R-HSA-9664417 6.239078e-01 0.205 0 0
Parasite infection R-HSA-9664407 6.239078e-01 0.205 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.239078e-01 0.205 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.241434e-01 0.205 0 0
HIV Transcription Elongation R-HSA-167169 6.241434e-01 0.205 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.241434e-01 0.205 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.323137e-01 0.199 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.396493e-01 0.194 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.396493e-01 0.194 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.396493e-01 0.194 0 0
Signaling by Activin R-HSA-1502540 6.396493e-01 0.194 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.396493e-01 0.194 0 0
Formation of the anterior neural plate R-HSA-9823739 6.396493e-01 0.194 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.396493e-01 0.194 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.396493e-01 0.194 0 0
Interferon gamma signaling R-HSA-877300 6.419761e-01 0.192 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.423028e-01 0.192 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 6.423028e-01 0.192 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.423028e-01 0.192 0 0
Maturation of spike protein R-HSA-9694548 6.423028e-01 0.192 0 0
Potential therapeutics for SARS R-HSA-9679191 6.429215e-01 0.192 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.433155e-01 0.192 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.433155e-01 0.192 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.433155e-01 0.192 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.433155e-01 0.192 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.433155e-01 0.192 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.433155e-01 0.192 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 6.433155e-01 0.192 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.433155e-01 0.192 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.433155e-01 0.192 0 0
MET Receptor Activation R-HSA-6806942 6.433155e-01 0.192 0 0
Abacavir transmembrane transport R-HSA-2161517 6.433155e-01 0.192 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.433155e-01 0.192 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.433155e-01 0.192 0 0
NADPH regeneration R-HSA-389542 6.433155e-01 0.192 0 0
Signaling by LTK in cancer R-HSA-9842640 6.433155e-01 0.192 0 0
VLDL assembly R-HSA-8866423 6.433155e-01 0.192 0 0
Leukotriene receptors R-HSA-391906 6.433155e-01 0.192 0 0
Formation of the ureteric bud R-HSA-9830674 6.449851e-01 0.190 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.454563e-01 0.190 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.559572e-01 0.183 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.599044e-01 0.181 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 6.619996e-01 0.179 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.645253e-01 0.177 1 1
Regulation of BACH1 activity R-HSA-9708530 6.670787e-01 0.176 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.670787e-01 0.176 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.670787e-01 0.176 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.670787e-01 0.176 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.670787e-01 0.176 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.670787e-01 0.176 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.672904e-01 0.176 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.672904e-01 0.176 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.675258e-01 0.176 0 0
Eukaryotic Translation Termination R-HSA-72764 6.678300e-01 0.175 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.714279e-01 0.173 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.714279e-01 0.173 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.749442e-01 0.171 0 0
PLC beta mediated events R-HSA-112043 6.749442e-01 0.171 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.794648e-01 0.168 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.819300e-01 0.166 0 0
Recycling of eIF2:GDP R-HSA-72731 6.819300e-01 0.166 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 6.819300e-01 0.166 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.819300e-01 0.166 0 0
LDL remodeling R-HSA-8964041 6.819300e-01 0.166 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.819300e-01 0.166 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.819300e-01 0.166 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.819300e-01 0.166 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.829456e-01 0.166 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.829456e-01 0.166 0 0
Parasitic Infection Pathways R-HSA-9824443 6.878371e-01 0.163 0 0
Leishmania infection R-HSA-9658195 6.878371e-01 0.163 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.885535e-01 0.162 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.885535e-01 0.162 0 0
Interleukin-7 signaling R-HSA-1266695 6.885535e-01 0.162 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 6.885535e-01 0.162 0 0
Formation of the nephric duct R-HSA-9830364 6.885535e-01 0.162 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.890979e-01 0.162 0 0
Dual Incision in GG-NER R-HSA-5696400 6.898735e-01 0.161 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.898735e-01 0.161 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.898735e-01 0.161 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.898735e-01 0.161 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.927949e-01 0.159 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.927949e-01 0.159 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.927949e-01 0.159 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.927949e-01 0.159 0 0
Synthesis of PG R-HSA-1483148 6.927949e-01 0.159 0 0
TBC/RABGAPs R-HSA-8854214 6.933896e-01 0.159 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.937352e-01 0.159 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.946756e-01 0.158 0 0
G alpha (q) signalling events R-HSA-416476 6.963780e-01 0.157 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.978913e-01 0.156 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.051935e-01 0.152 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.067862e-01 0.151 0 0
HCMV Late Events R-HSA-9610379 7.072362e-01 0.150 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.075716e-01 0.150 0 0
Ca2+ pathway R-HSA-4086398 7.080019e-01 0.150 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.087794e-01 0.149 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.087794e-01 0.149 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.087794e-01 0.149 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.087794e-01 0.149 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.092592e-01 0.149 0 0
Amine ligand-binding receptors R-HSA-375280 7.092592e-01 0.149 0 0
RMTs methylate histone arginines R-HSA-3214858 7.092592e-01 0.149 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.123576e-01 0.147 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.163663e-01 0.145 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.163663e-01 0.145 0 0
Co-stimulation by ICOS R-HSA-9927354 7.163663e-01 0.145 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.163663e-01 0.145 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.163663e-01 0.145 0 0
Modulation by Mtb of host immune system R-HSA-9637628 7.163663e-01 0.145 0 0
Interleukin-23 signaling R-HSA-9020933 7.163663e-01 0.145 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.168472e-01 0.145 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.168472e-01 0.145 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.168472e-01 0.145 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.168472e-01 0.145 0 0
Specification of primordial germ cells R-HSA-9827857 7.168472e-01 0.145 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.168472e-01 0.145 0 0
Calmodulin induced events R-HSA-111933 7.245226e-01 0.140 0 0
CaM pathway R-HSA-111997 7.245226e-01 0.140 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.245226e-01 0.140 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.245226e-01 0.140 0 0
G1/S-Specific Transcription R-HSA-69205 7.245226e-01 0.140 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.245426e-01 0.140 0 0
DAG and IP3 signaling R-HSA-1489509 7.245426e-01 0.140 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.245426e-01 0.140 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.245426e-01 0.140 0 0
Hemostasis R-HSA-109582 7.247764e-01 0.140 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.263414e-01 0.139 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.279797e-01 0.138 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.279797e-01 0.138 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.279797e-01 0.138 0 0
Signaling by BMP R-HSA-201451 7.279797e-01 0.138 0 0
Cellular response to hypoxia R-HSA-1234174 7.291260e-01 0.137 0 0
Mitochondrial biogenesis R-HSA-1592230 7.335024e-01 0.135 0 0
Glucose metabolism R-HSA-70326 7.335024e-01 0.135 0 0
Selenocysteine synthesis R-HSA-2408557 7.339077e-01 0.134 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.392400e-01 0.131 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.392945e-01 0.131 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.392945e-01 0.131 0 0
Mismatch Repair R-HSA-5358508 7.392945e-01 0.131 0 0
PKA activation in glucagon signalling R-HSA-164378 7.392945e-01 0.131 0 0
PKA activation R-HSA-163615 7.392945e-01 0.131 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.392945e-01 0.131 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.392945e-01 0.131 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.398412e-01 0.131 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.398412e-01 0.131 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.398412e-01 0.131 0 0
Voltage gated Potassium channels R-HSA-1296072 7.407312e-01 0.130 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.440270e-01 0.128 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.461718e-01 0.127 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.461718e-01 0.127 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.470760e-01 0.127 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.470760e-01 0.127 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.470760e-01 0.127 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.470760e-01 0.127 0 0
Lipophagy R-HSA-9613354 7.470760e-01 0.127 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.470760e-01 0.127 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.533540e-01 0.123 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.533540e-01 0.123 0 0
G-protein mediated events R-HSA-112040 7.537550e-01 0.123 0 0
Viral mRNA Translation R-HSA-192823 7.538853e-01 0.123 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.562052e-01 0.121 0 0
FCERI mediated MAPK activation R-HSA-2871796 7.574348e-01 0.121 0 0
Inositol phosphate metabolism R-HSA-1483249 7.574348e-01 0.121 0 0
Specification of the neural plate border R-HSA-9834899 7.602023e-01 0.119 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.602023e-01 0.119 0 0
Late endosomal microautophagy R-HSA-9615710 7.633778e-01 0.117 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.633778e-01 0.117 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.633778e-01 0.117 0 0
Opioid Signalling R-HSA-111885 7.634817e-01 0.117 0 0
Dual incision in TC-NER R-HSA-6782135 7.653929e-01 0.116 0 0
Transcription of the HIV genome R-HSA-167172 7.654513e-01 0.116 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.709553e-01 0.113 0 0
Binding and entry of HIV virion R-HSA-173107 7.744623e-01 0.111 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.744623e-01 0.111 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.744623e-01 0.111 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.744623e-01 0.111 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.744623e-01 0.111 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.744623e-01 0.111 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 7.771237e-01 0.110 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.796238e-01 0.108 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.796238e-01 0.108 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.796407e-01 0.108 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.796407e-01 0.108 0 0
Protein hydroxylation R-HSA-9629569 7.796407e-01 0.108 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.796407e-01 0.108 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.798530e-01 0.108 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.849950e-01 0.105 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.873885e-01 0.104 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.925660e-01 0.101 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.949388e-01 0.100 0 0
Cargo concentration in the ER R-HSA-5694530 7.949388e-01 0.100 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.949388e-01 0.100 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.976827e-01 0.098 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.976827e-01 0.098 0 0
Lagging Strand Synthesis R-HSA-69186 7.976827e-01 0.098 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.976827e-01 0.098 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.976827e-01 0.098 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.976827e-01 0.098 0 0
Hedgehog 'on' state R-HSA-5632684 7.980949e-01 0.098 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.983398e-01 0.098 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.988847e-01 0.098 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.988847e-01 0.098 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.988847e-01 0.098 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.988847e-01 0.098 0 0
vRNA Synthesis R-HSA-192814 7.988847e-01 0.098 0 0
vRNP Assembly R-HSA-192905 7.988847e-01 0.098 0 0
Chylomicron assembly R-HSA-8963888 7.988847e-01 0.098 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 7.988847e-01 0.098 0 0
Bicarbonate transporters R-HSA-425381 7.988847e-01 0.098 0 0
Transport of RCbl within the body R-HSA-9758890 7.988847e-01 0.098 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.988847e-01 0.098 0 0
Prostanoid ligand receptors R-HSA-391908 7.988847e-01 0.098 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.992447e-01 0.097 0 0
Interferon alpha/beta signaling R-HSA-909733 8.007502e-01 0.097 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.081745e-01 0.092 0 0
G0 and Early G1 R-HSA-1538133 8.093543e-01 0.092 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.110072e-01 0.091 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.110072e-01 0.091 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.110072e-01 0.091 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.110072e-01 0.091 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.135706e-01 0.090 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.144028e-01 0.089 0 0
Rab regulation of trafficking R-HSA-9007101 8.164087e-01 0.088 0 0
DS-GAG biosynthesis R-HSA-2022923 8.206638e-01 0.086 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.206638e-01 0.086 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.206638e-01 0.086 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.206638e-01 0.086 0 0
Scavenging by Class H Receptors R-HSA-3000497 8.206638e-01 0.086 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.206638e-01 0.086 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.206638e-01 0.086 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.206638e-01 0.086 0 0
Anchoring fibril formation R-HSA-2214320 8.206638e-01 0.086 0 0
G-protein beta:gamma signalling R-HSA-397795 8.229039e-01 0.085 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.229039e-01 0.085 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.298756e-01 0.081 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.298756e-01 0.081 0 0
LDL clearance R-HSA-8964038 8.298756e-01 0.081 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.298756e-01 0.081 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.298756e-01 0.081 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.319160e-01 0.080 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.343869e-01 0.079 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.356223e-01 0.078 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.400855e-01 0.076 0 0
Leading Strand Synthesis R-HSA-69109 8.400855e-01 0.076 0 0
Polymerase switching R-HSA-69091 8.400855e-01 0.076 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.400855e-01 0.076 0 0
Interleukin-15 signaling R-HSA-8983432 8.400855e-01 0.076 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.400855e-01 0.076 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.400855e-01 0.076 0 0
OAS antiviral response R-HSA-8983711 8.400855e-01 0.076 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.416918e-01 0.075 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.441752e-01 0.074 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.441752e-01 0.074 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.441752e-01 0.074 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.441752e-01 0.074 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.441752e-01 0.074 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.475451e-01 0.072 0 0
Signal amplification R-HSA-392518 8.475451e-01 0.072 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.490402e-01 0.071 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.573740e-01 0.067 0 0
Interleukin-6 family signaling R-HSA-6783589 8.573740e-01 0.067 0 0
Processing of SMDT1 R-HSA-8949664 8.574049e-01 0.067 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.574049e-01 0.067 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.574049e-01 0.067 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.574049e-01 0.067 0 0
Chylomicron remodeling R-HSA-8963901 8.574049e-01 0.067 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.574049e-01 0.067 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.574049e-01 0.067 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.574049e-01 0.067 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.574049e-01 0.067 0 0
Maturation of nucleoprotein R-HSA-9683610 8.574049e-01 0.067 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.574049e-01 0.067 0 0
Kidney development R-HSA-9830369 8.575446e-01 0.067 0 0
Formation of the cornified envelope R-HSA-6809371 8.640083e-01 0.063 0 0
Ion channel transport R-HSA-983712 8.657134e-01 0.063 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.695428e-01 0.061 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.695428e-01 0.061 0 0
Hyaluronan degradation R-HSA-2160916 8.695428e-01 0.061 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.695428e-01 0.061 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.728495e-01 0.059 0 0
Hydrolysis of LPC R-HSA-1483115 8.728495e-01 0.059 0 0
Biosynthesis of protectins R-HSA-9018681 8.728495e-01 0.059 0 0
Physiological factors R-HSA-5578768 8.728495e-01 0.059 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.728495e-01 0.059 0 0
Malate-aspartate shuttle R-HSA-9856872 8.728495e-01 0.059 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.728495e-01 0.059 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.728495e-01 0.059 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.728495e-01 0.059 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.789005e-01 0.056 0 0
Extension of Telomeres R-HSA-180786 8.805237e-01 0.055 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.805237e-01 0.055 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.807498e-01 0.055 0 0
TRP channels R-HSA-3295583 8.807498e-01 0.055 0 0
Innate Immune System R-HSA-168249 8.828319e-01 0.054 0 0
Platelet degranulation R-HSA-114608 8.864856e-01 0.052 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.866220e-01 0.052 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.866220e-01 0.052 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.866220e-01 0.052 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.866220e-01 0.052 0 0
Protein methylation R-HSA-8876725 8.866220e-01 0.052 0 0
DNA Damage Reversal R-HSA-73942 8.866220e-01 0.052 0 0
ABC-family proteins mediated transport R-HSA-382556 8.870990e-01 0.052 0 0
ECM proteoglycans R-HSA-3000178 8.876961e-01 0.052 0 0
Elastic fibre formation R-HSA-1566948 8.880011e-01 0.052 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.880070e-01 0.052 0 0
Integration of energy metabolism R-HSA-163685 8.903631e-01 0.050 0 0
Insulin processing R-HSA-264876 8.910605e-01 0.050 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.948949e-01 0.048 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.950838e-01 0.048 0 0
Pentose phosphate pathway R-HSA-71336 8.964848e-01 0.047 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.964848e-01 0.047 0 0
Signaling by ALK R-HSA-201556 8.964848e-01 0.047 0 0
PI Metabolism R-HSA-1483255 8.982764e-01 0.047 0 0
Phosphorylation of the APC/C R-HSA-176412 8.989035e-01 0.046 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.989035e-01 0.046 0 0
Negative regulation of FLT3 R-HSA-9706369 8.989035e-01 0.046 0 0
Activation of SMO R-HSA-5635838 8.989035e-01 0.046 0 0
Attachment and Entry R-HSA-9678110 8.989035e-01 0.046 0 0
Atorvastatin ADME R-HSA-9754706 8.989035e-01 0.046 0 0
Telomere Extension By Telomerase R-HSA-171319 9.005376e-01 0.045 0 0
Insulin receptor recycling R-HSA-77387 9.005376e-01 0.045 0 0
Pyroptosis R-HSA-5620971 9.005376e-01 0.045 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.043857e-01 0.044 0 0
Attenuation phase R-HSA-3371568 9.043857e-01 0.044 0 0
HSF1-dependent transactivation R-HSA-3371571 9.050215e-01 0.043 0 0
Immune System R-HSA-168256 9.061171e-01 0.043 0 0
mRNA Capping R-HSA-72086 9.092405e-01 0.041 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.092405e-01 0.041 0 0
Thyroxine biosynthesis R-HSA-209968 9.092405e-01 0.041 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.098553e-01 0.041 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.098553e-01 0.041 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.098553e-01 0.041 0 0
Phase 2 - plateau phase R-HSA-5576893 9.098553e-01 0.041 0 0
Passive transport by Aquaporins R-HSA-432047 9.098553e-01 0.041 0 0
Fibronectin matrix formation R-HSA-1566977 9.098553e-01 0.041 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.098553e-01 0.041 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.098553e-01 0.041 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.117981e-01 0.040 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.185016e-01 0.037 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.185709e-01 0.037 0 0
HIV Transcription Initiation R-HSA-167161 9.185709e-01 0.037 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.185709e-01 0.037 0 0
Intra-Golgi traffic R-HSA-6811438 9.185709e-01 0.037 0 0
Translation of Structural Proteins R-HSA-9683701 9.185709e-01 0.037 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.196212e-01 0.036 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.196212e-01 0.036 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.196212e-01 0.036 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.196212e-01 0.036 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.196212e-01 0.036 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.196212e-01 0.036 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.196212e-01 0.036 0 0
Potassium Channels R-HSA-1296071 9.216599e-01 0.035 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.226788e-01 0.035 0 0
Translation of Structural Proteins R-HSA-9694635 9.226788e-01 0.035 0 0
Trafficking of AMPA receptors R-HSA-399719 9.245469e-01 0.034 0 0
Activation of GABAB receptors R-HSA-991365 9.249183e-01 0.034 0 0
GABA B receptor activation R-HSA-977444 9.249183e-01 0.034 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.249183e-01 0.034 0 0
ABC transporter disorders R-HSA-5619084 9.274730e-01 0.033 0 0
Nephron development R-HSA-9831926 9.283296e-01 0.032 0 0
Polo-like kinase mediated events R-HSA-156711 9.283296e-01 0.032 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.283296e-01 0.032 0 0
Stimuli-sensing channels R-HSA-2672351 9.303570e-01 0.031 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.308089e-01 0.031 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.312538e-01 0.031 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.360950e-01 0.029 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.360950e-01 0.029 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.360950e-01 0.029 0 0
Pyrimidine biosynthesis R-HSA-500753 9.360950e-01 0.029 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.360950e-01 0.029 0 0
Diseases of hemostasis R-HSA-9671793 9.360950e-01 0.029 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.360950e-01 0.029 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.360950e-01 0.029 0 0
Maturation of nucleoprotein R-HSA-9694631 9.360950e-01 0.029 0 0
Other interleukin signaling R-HSA-449836 9.360950e-01 0.029 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.360950e-01 0.029 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.373936e-01 0.028 0 0
Cellular response to starvation R-HSA-9711097 9.389485e-01 0.027 1 0
Synthesis of PA R-HSA-1483166 9.389738e-01 0.027 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.413329e-01 0.026 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.413329e-01 0.026 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.430105e-01 0.025 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.430105e-01 0.025 0 0
Heme degradation R-HSA-189483 9.430105e-01 0.025 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.430194e-01 0.025 0 0
Creatine metabolism R-HSA-71288 9.430194e-01 0.025 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.430194e-01 0.025 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.430194e-01 0.025 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.434163e-01 0.025 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.434163e-01 0.025 0 0
tRNA processing R-HSA-72306 9.457362e-01 0.024 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.481457e-01 0.023 0 0
eNOS activation R-HSA-203615 9.481457e-01 0.023 0 0
Hyaluronan metabolism R-HSA-2142845 9.481457e-01 0.023 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.481457e-01 0.023 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.491939e-01 0.023 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.491939e-01 0.023 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.491939e-01 0.023 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.491939e-01 0.023 0 0
Metabolism of polyamines R-HSA-351202 9.514264e-01 0.022 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.528376e-01 0.021 0 0
RSV-host interactions R-HSA-9833110 9.540033e-01 0.020 0 0
GPER1 signaling R-HSA-9634597 9.543654e-01 0.020 0 0
Gluconeogenesis R-HSA-70263 9.543654e-01 0.020 0 0
CS-GAG biosynthesis R-HSA-2022870 9.546997e-01 0.020 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.546997e-01 0.020 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 9.546997e-01 0.020 0 0
Assembly Of The HIV Virion R-HSA-175474 9.546997e-01 0.020 0 0
Glutathione synthesis and recycling R-HSA-174403 9.546997e-01 0.020 0 0
Attachment and Entry R-HSA-9694614 9.546997e-01 0.020 0 0
Ribavirin ADME R-HSA-9755088 9.546997e-01 0.020 0 0
Mitochondrial protein import R-HSA-1268020 9.583816e-01 0.018 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.596091e-01 0.018 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.596091e-01 0.018 0 0
Ethanol oxidation R-HSA-71384 9.596091e-01 0.018 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.596091e-01 0.018 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.603463e-01 0.018 0 0
Collagen chain trimerization R-HSA-8948216 9.610319e-01 0.017 0 0
Azathioprine ADME R-HSA-9748787 9.614918e-01 0.017 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.639867e-01 0.016 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.639867e-01 0.016 0 0
Carnitine shuttle R-HSA-200425 9.639867e-01 0.016 0 0
Interleukin-20 family signaling R-HSA-8854691 9.639867e-01 0.016 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.643407e-01 0.016 0 0
Purine salvage R-HSA-74217 9.645983e-01 0.016 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.645983e-01 0.016 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.645983e-01 0.016 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.678496e-01 0.014 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.678496e-01 0.014 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.678900e-01 0.014 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.678900e-01 0.014 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.678900e-01 0.014 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.708123e-01 0.013 0 0
Glycogen metabolism R-HSA-8982491 9.708123e-01 0.013 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.713705e-01 0.013 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.713705e-01 0.013 0 0
G protein gated Potassium channels R-HSA-1296059 9.713705e-01 0.013 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.713705e-01 0.013 0 0
Laminin interactions R-HSA-3000157 9.713705e-01 0.013 0 0
Extracellular matrix organization R-HSA-1474244 9.737651e-01 0.012 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.744740e-01 0.011 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.744740e-01 0.011 0 0
Abacavir ADME R-HSA-2161522 9.744740e-01 0.011 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.744740e-01 0.011 0 0
G alpha (z) signalling events R-HSA-418597 9.749971e-01 0.011 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.755078e-01 0.011 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.759673e-01 0.011 0 0
PPARA activates gene expression R-HSA-1989781 9.770672e-01 0.010 0 0
FCGR activation R-HSA-2029481 9.771940e-01 0.010 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.772411e-01 0.010 0 0
Triglyceride biosynthesis R-HSA-75109 9.772411e-01 0.010 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.772411e-01 0.010 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.774484e-01 0.010 0 0
COPII-mediated vesicle transport R-HSA-204005 9.779555e-01 0.010 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.782028e-01 0.010 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.782028e-01 0.010 0 0
Collagen formation R-HSA-1474290 9.787718e-01 0.009 0 0
Dectin-2 family R-HSA-5621480 9.790212e-01 0.009 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.795382e-01 0.009 0 0
Prednisone ADME R-HSA-9757110 9.797085e-01 0.009 0 0
Pyrimidine salvage R-HSA-73614 9.797085e-01 0.009 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.798494e-01 0.009 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.819085e-01 0.008 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.819085e-01 0.008 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.821672e-01 0.008 0 0
Peroxisomal protein import R-HSA-9033241 9.824229e-01 0.008 0 0
Infectious disease R-HSA-5663205 9.828537e-01 0.008 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.837655e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.838700e-01 0.007 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.838700e-01 0.007 0 0
GABA receptor activation R-HSA-977443 9.839193e-01 0.007 0 0
tRNA Aminoacylation R-HSA-379724 9.839193e-01 0.007 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.840873e-01 0.007 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.841063e-01 0.007 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.852922e-01 0.006 0 0
Aquaporin-mediated transport R-HSA-445717 9.852932e-01 0.006 0 0
Iron uptake and transport R-HSA-917937 9.853674e-01 0.006 0 0
Budding and maturation of HIV virion R-HSA-162588 9.856190e-01 0.006 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.856190e-01 0.006 0 0
Selenoamino acid metabolism R-HSA-2408522 9.863956e-01 0.006 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.866789e-01 0.006 0 0
Protein localization R-HSA-9609507 9.868463e-01 0.006 0 0
DAG1 glycosylations R-HSA-8931838 9.871785e-01 0.006 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.879379e-01 0.005 0 0
Metal ion SLC transporters R-HSA-425410 9.879379e-01 0.005 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.885689e-01 0.005 0 0
Recycling of bile acids and salts R-HSA-159418 9.885689e-01 0.005 0 0
CS/DS degradation R-HSA-2024101 9.898086e-01 0.004 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.898086e-01 0.004 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.898086e-01 0.004 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.906680e-01 0.004 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.909139e-01 0.004 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.909139e-01 0.004 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.909139e-01 0.004 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.909139e-01 0.004 0 0
The phototransduction cascade R-HSA-2514856 9.910577e-01 0.004 0 0
Nicotinate metabolism R-HSA-196807 9.914505e-01 0.004 0 0
Post-translational protein modification R-HSA-597592 9.918475e-01 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.918994e-01 0.004 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.921976e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.925817e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.925817e-01 0.003 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.926835e-01 0.003 0 0
Nucleotide biosynthesis R-HSA-8956320 9.926835e-01 0.003 0 0
HS-GAG biosynthesis R-HSA-2022928 9.927781e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.927781e-01 0.003 0 0
Triglyceride catabolism R-HSA-163560 9.927781e-01 0.003 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.927781e-01 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.935070e-01 0.003 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.935615e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.935615e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.935615e-01 0.003 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.937569e-01 0.003 0 0
Paracetamol ADME R-HSA-9753281 9.940188e-01 0.003 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.945937e-01 0.002 0 0
Purine catabolism R-HSA-74259 9.946023e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.946023e-01 0.002 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.948827e-01 0.002 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.954379e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.959329e-01 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.959329e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.960123e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.962642e-01 0.002 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.963742e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.963983e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.967475e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.967475e-01 0.001 0 0
Neddylation R-HSA-8951664 9.968031e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.969175e-01 0.001 0 0
Disease R-HSA-1643685 9.969938e-01 0.001 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.971184e-01 0.001 0 0
Methylation R-HSA-156581 9.974312e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.974312e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.974312e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.974312e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.976073e-01 0.001 0 0
SLC transporter disorders R-HSA-5619102 9.976288e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.977100e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.977100e-01 0.001 0 0
Translation R-HSA-72766 9.978631e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.979355e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.979585e-01 0.001 0 0
Regulation of insulin secretion R-HSA-422356 9.984625e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.985538e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.985538e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.985857e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.986622e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.986893e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.987108e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.988374e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.988374e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.988374e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.988374e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.988508e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.988508e-01 0.000 0 0
Keratinization R-HSA-6805567 9.992107e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.992327e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.992744e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.994166e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.994234e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.994512e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.995419e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.995419e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.995901e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.995916e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.995916e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.996360e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.997009e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.997422e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.997552e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.997946e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.997971e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.998038e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.998175e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998360e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998373e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998993e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999339e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999409e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999448e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999449e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999636e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999706e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999767e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999817e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999895e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999897e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999908e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999923e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999954e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999960e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999964e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999968e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999989e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999991e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999991e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999992e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999992e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999993e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999993e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999996e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999997e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999998e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999998e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
M Phase R-HSA-68886 2.225997e-12 11.652 0 0
Chromatin organization R-HSA-4839726 2.504108e-12 11.601 0 0
Mitotic Prophase R-HSA-68875 4.089173e-12 11.388 0 0
Chromatin modifying enzymes R-HSA-3247509 4.351741e-12 11.361 0 0
Cell Cycle R-HSA-1640170 9.617973e-12 11.017 0 0
Cell Cycle, Mitotic R-HSA-69278 6.508172e-11 10.187 0 0
Cellular Senescence R-HSA-2559583 6.644878e-10 9.178 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.292982e-09 8.888 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.281710e-09 8.368 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.676188e-09 8.330 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.950394e-09 8.305 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.090401e-08 7.962 0 0
HDACs deacetylate histones R-HSA-3214815 4.105928e-08 7.387 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.322051e-08 7.274 0 0
Gene Silencing by RNA R-HSA-211000 7.666301e-08 7.115 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 8.823477e-08 7.054 0 0
HATs acetylate histones R-HSA-3214847 1.234514e-07 6.909 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.345442e-07 6.630 0 0
RNA Polymerase I Transcription R-HSA-73864 2.756148e-07 6.560 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.347533e-07 6.475 0 0
Meiotic synapsis R-HSA-1221632 3.656622e-07 6.437 0 0
mRNA Splicing R-HSA-72172 4.101591e-07 6.387 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.262142e-07 6.370 0 0
Cellular responses to stress R-HSA-2262752 4.490038e-07 6.348 1 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.950482e-07 6.225 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.889147e-07 6.230 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.538600e-07 6.185 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.538600e-07 6.185 0 0
Metabolism of RNA R-HSA-8953854 6.961834e-07 6.157 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.307192e-06 5.884 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.270276e-06 5.644 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.396676e-06 5.620 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.745812e-06 5.561 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.151243e-06 5.502 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.614217e-06 5.442 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.683066e-06 5.434 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.210923e-06 5.376 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.930666e-06 5.307 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.570931e-06 5.254 0 0
Cellular responses to stimuli R-HSA-8953897 5.766639e-06 5.239 1 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.812664e-06 5.167 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 7.084341e-06 5.150 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.163809e-06 5.145 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.475309e-06 5.126 0 0
Packaging Of Telomere Ends R-HSA-171306 7.963771e-06 5.099 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.358603e-06 5.029 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.026265e-05 4.989 0 0
Apoptotic execution phase R-HSA-75153 1.156343e-05 4.937 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.202048e-05 4.920 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.233636e-05 4.909 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.350334e-05 4.870 0 0
DNA methylation R-HSA-5334118 1.516861e-05 4.819 0 0
Protein ubiquitination R-HSA-8852135 1.470132e-05 4.833 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.717052e-05 4.765 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.785049e-05 4.748 0 0
Defective pyroptosis R-HSA-9710421 1.998878e-05 4.699 0 0
Nuclear import of Rev protein R-HSA-180746 2.125872e-05 4.672 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.993607e-05 4.524 0 0
Meiosis R-HSA-1500620 2.977738e-05 4.526 0 0
Cell Cycle Checkpoints R-HSA-69620 2.873796e-05 4.542 0 0
Homology Directed Repair R-HSA-5693538 3.427501e-05 4.465 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.459515e-05 4.461 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.578704e-05 4.446 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.666289e-05 4.436 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.687822e-05 4.433 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.908785e-05 4.408 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.225113e-05 4.374 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.469750e-05 4.350 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.542268e-05 4.343 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.822721e-05 4.317 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.682263e-05 4.330 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.985415e-05 4.302 0 0
Cellular response to heat stress R-HSA-3371556 5.099683e-05 4.292 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.815689e-05 4.235 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.286095e-05 4.202 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 7.621803e-05 4.118 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.621803e-05 4.118 0 0
Deubiquitination R-HSA-5688426 8.155838e-05 4.089 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.122522e-05 4.090 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 8.349925e-05 4.078 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.620580e-05 4.017 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.620580e-05 4.017 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.620580e-05 4.017 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.076449e-04 3.968 0 0
Nucleosome assembly R-HSA-774815 1.076449e-04 3.968 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.090800e-04 3.962 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.090800e-04 3.962 0 0
Meiotic recombination R-HSA-912446 1.155031e-04 3.937 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.206191e-04 3.919 0 0
Diseases of programmed cell death R-HSA-9645723 1.472231e-04 3.832 0 0
Cleavage of the damaged purine R-HSA-110331 1.670013e-04 3.777 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.810443e-04 3.742 0 0
Depurination R-HSA-73927 2.092310e-04 3.679 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.286021e-04 3.641 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.302369e-04 3.638 0 0
DNA Double Strand Break Response R-HSA-5693606 2.400792e-04 3.620 0 0
Mitotic Anaphase R-HSA-68882 2.594149e-04 3.586 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.910561e-04 3.536 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.823812e-04 3.549 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.900861e-04 3.537 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.149813e-04 3.502 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.217307e-04 3.493 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.351988e-04 3.475 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.351988e-04 3.475 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.635935e-04 3.439 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.643924e-04 3.438 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.953474e-04 3.403 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.126116e-04 3.384 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.135728e-04 3.383 0 0
Metabolism of non-coding RNA R-HSA-194441 4.881321e-04 3.311 0 0
snRNP Assembly R-HSA-191859 4.881321e-04 3.311 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.214687e-04 3.283 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.390552e-04 3.268 0 0
HCMV Early Events R-HSA-9609690 5.616169e-04 3.251 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.860559e-04 3.232 0 0
Depyrimidination R-HSA-73928 5.860559e-04 3.232 0 0
Translation initiation complex formation R-HSA-72649 5.902598e-04 3.229 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.836177e-04 3.165 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.143833e-04 3.146 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.312595e-04 3.136 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.312595e-04 3.136 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.202175e-04 3.086 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.940770e-04 3.100 0 0
HCMV Late Events R-HSA-9610379 8.586100e-04 3.066 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.026967e-03 2.988 0 0
Signaling by ALK in cancer R-HSA-9700206 1.026967e-03 2.988 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.029017e-03 2.988 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.029017e-03 2.988 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.093381e-03 2.961 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.141375e-03 2.943 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.148403e-03 2.940 0 0
G2/M Checkpoints R-HSA-69481 1.212469e-03 2.916 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.213714e-03 2.916 0 0
Telomere Maintenance R-HSA-157579 1.436441e-03 2.843 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.683008e-03 2.774 0 0
Influenza Infection R-HSA-168255 1.686780e-03 2.773 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.052955e-03 2.688 0 0
Regulation of TP53 Activity R-HSA-5633007 2.133948e-03 2.671 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.181550e-03 2.661 0 0
DNA Replication R-HSA-69306 2.241101e-03 2.650 0 0
ESR-mediated signaling R-HSA-8939211 2.298953e-03 2.638 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.331758e-03 2.632 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.331758e-03 2.632 0 0
DNA Repair R-HSA-73894 2.390948e-03 2.621 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.484055e-03 2.605 0 0
Mitotic Prometaphase R-HSA-68877 2.720714e-03 2.565 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.833843e-03 2.548 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.016926e-03 2.520 0 0
HIV Life Cycle R-HSA-162587 3.110459e-03 2.507 0 0
Adherens junctions interactions R-HSA-418990 3.199901e-03 2.495 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.309502e-03 2.480 0 0
Host Interactions of HIV factors R-HSA-162909 3.332338e-03 2.477 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.377419e-03 2.471 0 0
Reproduction R-HSA-1474165 3.489583e-03 2.457 0 0
Ub-specific processing proteases R-HSA-5689880 3.505395e-03 2.455 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.574738e-03 2.447 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.982339e-03 2.400 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.982339e-03 2.400 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.982339e-03 2.400 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.202905e-03 2.376 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.142066e-03 2.383 0 0
Cell junction organization R-HSA-446728 3.951203e-03 2.403 0 0
Glycolysis R-HSA-70171 4.202905e-03 2.376 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.117371e-03 2.385 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.297265e-03 2.367 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.504394e-03 2.346 0 0
Chromosome Maintenance R-HSA-73886 4.962962e-03 2.304 0 0
Interleukin-12 signaling R-HSA-9020591 4.983507e-03 2.302 0 0
Cell-Cell communication R-HSA-1500931 5.183979e-03 2.285 0 0
HCMV Infection R-HSA-9609646 5.242352e-03 2.280 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.384597e-03 2.269 0 0
HIV Infection R-HSA-162906 5.730500e-03 2.242 0 0
Gene expression (Transcription) R-HSA-74160 5.918004e-03 2.228 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 6.001828e-03 2.222 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.137319e-03 2.212 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.168150e-03 2.210 1 1
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.222809e-03 2.206 0 0
ALK mutants bind TKIs R-HSA-9700645 7.239738e-03 2.140 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.074433e-03 2.150 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.074433e-03 2.150 0 0
Ribosome-associated quality control R-HSA-9948299 7.301921e-03 2.137 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.239738e-03 2.140 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 7.583117e-03 2.120 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 7.583117e-03 2.120 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 7.583117e-03 2.120 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 7.583117e-03 2.120 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 7.583117e-03 2.120 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 7.583117e-03 2.120 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 7.583117e-03 2.120 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 7.583117e-03 2.120 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 7.583117e-03 2.120 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 7.583117e-03 2.120 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 7.583117e-03 2.120 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.700905e-03 2.113 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.892015e-03 2.103 0 0
Membrane Trafficking R-HSA-199991 8.494328e-03 2.071 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.900944e-03 2.051 0 0
Macroautophagy R-HSA-1632852 9.160055e-03 2.038 0 0
Separation of Sister Chromatids R-HSA-2467813 9.332516e-03 2.030 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 9.615669e-03 2.017 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.975924e-03 2.001 0 0
Josephin domain DUBs R-HSA-5689877 9.980460e-03 2.001 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 9.980460e-03 2.001 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.060093e-02 1.975 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.212700e-02 1.916 0 0
tRNA processing in the nucleus R-HSA-6784531 1.115220e-02 1.953 0 0
Base Excision Repair R-HSA-73884 1.106032e-02 1.956 0 0
rRNA processing R-HSA-72312 1.243875e-02 1.905 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.246248e-02 1.904 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.246248e-02 1.904 0 0
NRAGE signals death through JNK R-HSA-193648 1.257019e-02 1.901 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.296328e-02 1.887 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.296328e-02 1.887 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.327340e-02 1.877 0 0
IRE1alpha activates chaperones R-HSA-381070 1.327340e-02 1.877 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.335955e-02 1.874 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.401432e-02 1.853 0 0
Cell-cell junction organization R-HSA-421270 1.404036e-02 1.853 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.447792e-02 1.839 0 0
Signaling by ROBO receptors R-HSA-376176 1.490991e-02 1.827 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.700374e-02 1.769 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.700374e-02 1.769 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.700374e-02 1.769 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.700374e-02 1.769 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.700374e-02 1.769 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.700374e-02 1.769 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.700374e-02 1.769 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.700374e-02 1.769 0 0
Phosphorylation of the APC/C R-HSA-176412 1.539136e-02 1.813 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.539136e-02 1.813 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.581898e-02 1.801 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.681206e-02 1.774 0 0
Autophagy R-HSA-9612973 1.597864e-02 1.796 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.580999e-02 1.801 0 0
Interleukin-12 family signaling R-HSA-447115 1.664446e-02 1.779 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.733490e-02 1.761 0 0
Amyloid fiber formation R-HSA-977225 1.745287e-02 1.758 0 0
Programmed Cell Death R-HSA-5357801 1.766945e-02 1.753 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.800276e-02 1.745 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.800276e-02 1.745 0 0
Peptide chain elongation R-HSA-156902 1.817354e-02 1.741 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.830419e-02 1.737 0 0
Disorders of Developmental Biology R-HSA-9675151 1.902902e-02 1.721 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.902902e-02 1.721 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.902902e-02 1.721 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.940980e-02 1.712 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.953205e-02 1.709 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.971114e-02 1.705 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.976014e-02 1.704 0 0
Smooth Muscle Contraction R-HSA-445355 1.997208e-02 1.700 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.114152e-02 1.675 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.165441e-02 1.664 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.225847e-02 1.653 0 0
Glucose metabolism R-HSA-70326 2.271484e-02 1.644 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.279122e-02 1.642 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.321278e-02 1.634 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.588074e-02 1.587 0 0
G alpha (12/13) signalling events R-HSA-416482 2.624614e-02 1.581 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.749502e-02 1.561 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.797283e-02 1.553 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.799892e-02 1.553 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.885240e-02 1.540 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.927879e-02 1.533 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.278325e-02 1.484 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.333532e-02 1.477 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.333532e-02 1.477 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.301193e-02 1.481 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.458284e-02 1.461 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.594705e-02 1.444 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.588013e-02 1.445 0 0
Co-inhibition by PD-1 R-HSA-389948 3.149353e-02 1.502 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.301193e-02 1.481 0 0
Eukaryotic Translation Termination R-HSA-72764 3.721920e-02 1.429 0 0
Apoptosis R-HSA-109581 3.742012e-02 1.427 0 0
mRNA 3'-end processing R-HSA-72187 3.855305e-02 1.414 0 0
Neurexins and neuroligins R-HSA-6794361 3.855305e-02 1.414 0 0
Centrosome maturation R-HSA-380287 3.906513e-02 1.408 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.932201e-02 1.405 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.932201e-02 1.405 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.932201e-02 1.405 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.932201e-02 1.405 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.932201e-02 1.405 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.932201e-02 1.405 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.987945e-02 1.399 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.993362e-02 1.399 0 0
Kinesins R-HSA-983189 4.033894e-02 1.394 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.101697e-02 1.387 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.146512e-02 1.382 0 0
Metalloprotease DUBs R-HSA-5689901 4.146512e-02 1.382 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.159818e-02 1.381 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.190533e-02 1.378 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.298417e-02 1.367 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 4.558992e-02 1.341 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.558992e-02 1.341 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.558992e-02 1.341 0 0
Attenuation phase R-HSA-3371568 4.614085e-02 1.336 0 0
Striated Muscle Contraction R-HSA-390522 4.726359e-02 1.325 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.970715e-02 1.304 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.970715e-02 1.304 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 4.975218e-02 1.303 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.195478e-02 1.284 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.243224e-02 1.280 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.273542e-02 1.278 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.304967e-02 1.275 0 0
Mitophagy R-HSA-5205647 5.304967e-02 1.275 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.323204e-02 1.274 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.419101e-02 1.266 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.747392e-02 1.241 0 0
DNA Damage Bypass R-HSA-73893 5.937466e-02 1.226 0 0
Diseases of cellular response to stress R-HSA-9675132 5.985486e-02 1.223 0 0
Diseases of Cellular Senescence R-HSA-9630747 5.985486e-02 1.223 0 0
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) R-HSA-1299308 5.985486e-02 1.223 0 0
FGFR2 alternative splicing R-HSA-6803529 6.117555e-02 1.213 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 6.173467e-02 1.209 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.143228e-02 1.212 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.490104e-02 1.126 0 0
Integration of provirus R-HSA-162592 6.263247e-02 1.203 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.482272e-02 1.188 0 0
DARPP-32 events R-HSA-180024 6.092581e-02 1.215 0 0
HSF1-dependent transactivation R-HSA-3371571 7.093292e-02 1.149 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.847063e-02 1.164 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.206777e-02 1.142 0 0
Selective autophagy R-HSA-9663891 6.143228e-02 1.212 0 0
Cellular response to starvation R-HSA-9711097 7.312615e-02 1.136 1 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.092719e-02 1.149 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.263247e-02 1.203 0 0
Notch-HLH transcription pathway R-HSA-350054 6.117555e-02 1.213 0 0
Signaling by WNT R-HSA-195721 7.341081e-02 1.134 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.263247e-02 1.203 0 0
Signaling by NOTCH R-HSA-157118 6.229147e-02 1.206 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.513720e-02 1.124 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.529150e-02 1.123 0 0
Disorders of Nervous System Development R-HSA-9697154 7.529150e-02 1.123 0 0
Pervasive developmental disorders R-HSA-9005895 7.529150e-02 1.123 0 0
RMTs methylate histone arginines R-HSA-3214858 7.576490e-02 1.121 0 0
UCH proteinases R-HSA-5689603 7.703587e-02 1.113 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.720884e-02 1.112 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.737715e-02 1.111 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.737715e-02 1.111 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.762814e-02 1.110 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.790633e-02 1.108 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.838012e-02 1.106 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.905439e-02 1.102 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.905439e-02 1.102 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 7.944175e-02 1.100 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.102675e-02 1.091 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.186592e-02 1.087 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 8.381857e-02 1.077 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.381857e-02 1.077 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 8.780736e-02 1.056 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 8.780736e-02 1.056 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 8.780736e-02 1.056 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 8.780736e-02 1.056 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 8.780736e-02 1.056 0 0
RNA Polymerase II Transcription R-HSA-73857 8.836453e-02 1.054 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.898180e-02 1.051 0 0
Sema4D in semaphorin signaling R-HSA-400685 8.898180e-02 1.051 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.913239e-02 1.050 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.913239e-02 1.050 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.026877e-02 1.044 0 0
Nervous system development R-HSA-9675108 9.208531e-02 1.036 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.227785e-02 1.035 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.280938e-02 1.032 0 0
Selenocysteine synthesis R-HSA-2408557 9.314509e-02 1.031 0 0
Axon guidance R-HSA-422475 9.331325e-02 1.030 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.374261e-02 1.028 0 0
Defective SFTPA2 causes IPF R-HSA-5687868 9.374261e-02 1.028 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 9.374261e-02 1.028 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 9.374261e-02 1.028 0 0
Nuclear RNA decay R-HSA-9930044 9.430508e-02 1.025 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 9.606579e-02 1.017 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 9.606579e-02 1.017 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.804084e-02 1.009 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.809312e-02 1.008 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 9.955523e-02 1.002 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.955523e-02 1.002 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.017743e-01 0.992 0 0
S Phase R-HSA-69242 1.033090e-01 0.986 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.039702e-01 0.983 0 0
Viral mRNA Translation R-HSA-192823 1.040887e-01 0.983 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.040994e-01 0.983 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.056514e-01 0.976 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.056514e-01 0.976 0 0
NGF-stimulated transcription R-HSA-9031628 1.062960e-01 0.973 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.187821e-01 0.925 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.187821e-01 0.925 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.381438e-01 0.860 0 0
2-LTR circle formation R-HSA-164843 1.381438e-01 0.860 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.381438e-01 0.860 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.201261e-01 0.920 0 0
Late endosomal microautophagy R-HSA-9615710 1.349866e-01 0.870 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.349866e-01 0.870 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.427920e-01 0.845 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.167025e-01 0.933 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.152301e-01 0.938 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.133860e-01 0.945 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.350787e-01 0.869 0 0
TBC/RABGAPs R-HSA-8854214 1.351246e-01 0.869 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.201261e-01 0.920 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.094204e-01 0.961 0 0
HSF1 activation R-HSA-3371511 1.359963e-01 0.866 0 0
Calmodulin induced events R-HSA-111933 1.359963e-01 0.866 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.201261e-01 0.920 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.107601e-01 0.956 0 0
CaM pathway R-HSA-111997 1.359963e-01 0.866 0 0
Protein methylation R-HSA-8876725 1.201261e-01 0.920 0 0
G2/M Transition R-HSA-69275 1.188552e-01 0.925 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.282175e-01 0.892 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.163849e-01 0.934 0 0
Inositol phosphate metabolism R-HSA-1483249 1.119606e-01 0.951 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.329273e-01 0.876 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 1.453726e-01 0.838 0 0
mTORC1-mediated signalling R-HSA-166208 1.453726e-01 0.838 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.453726e-01 0.838 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.476343e-01 0.831 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.476343e-01 0.831 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.479612e-01 0.830 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.483099e-01 0.829 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.505813e-01 0.822 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.519677e-01 0.818 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.519677e-01 0.818 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.519677e-01 0.818 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.519677e-01 0.818 0 0
Viral Infection Pathways R-HSA-9824446 1.526937e-01 0.816 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.528005e-01 0.816 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.528005e-01 0.816 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.550048e-01 0.810 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.550521e-01 0.810 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 1.550521e-01 0.810 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.550521e-01 0.810 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.550521e-01 0.810 0 0
Sensory processing of sound R-HSA-9659379 1.562145e-01 0.806 0 0
Signaling by VEGF R-HSA-194138 1.565393e-01 0.805 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.566335e-01 0.805 0 0
DAG and IP3 signaling R-HSA-1489509 1.566335e-01 0.805 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.607348e-01 0.794 0 0
Signaling by APC mutants R-HSA-4839744 1.611473e-01 0.793 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.611473e-01 0.793 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.611473e-01 0.793 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.611473e-01 0.793 0 0
Muscle contraction R-HSA-397014 1.620835e-01 0.790 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.631437e-01 0.787 0 0
Semaphorin interactions R-HSA-373755 1.678851e-01 0.775 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.679601e-01 0.775 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.679601e-01 0.775 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.679601e-01 0.775 0 0
Signaling by RAS mutants R-HSA-6802949 1.679601e-01 0.775 0 0
Hereditary fructose intolerance R-HSA-5657560 1.787026e-01 0.748 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 1.787026e-01 0.748 0 0
UNC93B1 deficiency - HSE R-HSA-5602415 1.787026e-01 0.748 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.787026e-01 0.748 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.787026e-01 0.748 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.787026e-01 0.748 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.557022e-01 0.592 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.557022e-01 0.592 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.557022e-01 0.592 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.557022e-01 0.592 0 0
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) R-HSA-5619048 2.557022e-01 0.592 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.557022e-01 0.592 0 0
Defective APRT disrupts adenine salvage R-HSA-9734195 2.557022e-01 0.592 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.557022e-01 0.592 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.557022e-01 0.592 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.557022e-01 0.592 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.557022e-01 0.592 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 1.866781e-01 0.729 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 1.866781e-01 0.729 0 0
CREB phosphorylation R-HSA-199920 2.223362e-01 0.653 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.223362e-01 0.653 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.852002e-01 0.732 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.852002e-01 0.732 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.101117e-01 0.678 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.101117e-01 0.678 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.101117e-01 0.678 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.101117e-01 0.678 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.101117e-01 0.678 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.101117e-01 0.678 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.356979e-01 0.628 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.932415e-01 0.714 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.767184e-01 0.753 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.133352e-01 0.671 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.754935e-01 0.756 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.722457e-01 0.764 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.278745e-01 0.642 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.278745e-01 0.642 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.278745e-01 0.642 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.049226e-01 0.688 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.847878e-01 0.733 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.520026e-01 0.599 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.323097e-01 0.634 0 0
RNA Polymerase III Transcription R-HSA-74158 2.520026e-01 0.599 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.984927e-01 0.702 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.116348e-01 0.674 0 0
MAP2K and MAPK activation R-HSA-5674135 2.121695e-01 0.673 0 0
MTOR signalling R-HSA-165159 2.261808e-01 0.646 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.202615e-01 0.657 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 1.866781e-01 0.729 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.852002e-01 0.732 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.101117e-01 0.678 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.101117e-01 0.678 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.520026e-01 0.599 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.556235e-01 0.592 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.556235e-01 0.592 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.550625e-01 0.593 0 0
PCP/CE pathway R-HSA-4086400 2.323219e-01 0.634 0 0
Synthesis of DNA R-HSA-69239 2.019233e-01 0.695 0 0
Oncogene Induced Senescence R-HSA-2559585 2.359675e-01 0.627 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.101117e-01 0.678 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.899880e-01 0.721 0 0
L1CAM interactions R-HSA-373760 2.178480e-01 0.662 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.147174e-01 0.668 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.713279e-01 0.766 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.520026e-01 0.599 0 0
Formation of definitive endoderm R-HSA-9823730 2.339726e-01 0.631 0 0
Apoptotic factor-mediated response R-HSA-111471 1.932415e-01 0.714 0 0
PTEN Regulation R-HSA-6807070 2.054828e-01 0.687 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.866781e-01 0.729 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.866781e-01 0.729 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.852002e-01 0.732 0 0
Cilium Assembly R-HSA-5617833 1.890243e-01 0.723 0 0
G0 and Early G1 R-HSA-1538133 1.754935e-01 0.756 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.796477e-01 0.746 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.713279e-01 0.766 0 0
HDMs demethylate histones R-HSA-3214842 1.932720e-01 0.714 0 0
Vesicle-mediated transport R-HSA-5653656 1.835810e-01 0.736 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.899880e-01 0.721 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.849980e-01 0.733 0 0
Inhibition of PKR R-HSA-169131 1.787026e-01 0.748 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.557022e-01 0.592 0 0
Signaling by AXIN mutants R-HSA-4839735 1.852002e-01 0.732 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.852002e-01 0.732 0 0
Neurodegenerative Diseases R-HSA-8863678 1.767184e-01 0.753 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.767184e-01 0.753 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.202615e-01 0.657 0 0
Regulation of CDH1 Function R-HSA-9764561 1.960628e-01 0.708 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.772658e-01 0.751 0 0
Opioid Signalling R-HSA-111885 2.485065e-01 0.605 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.133352e-01 0.671 0 0
Ca-dependent events R-HSA-111996 2.261808e-01 0.646 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.261808e-01 0.646 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.339726e-01 0.631 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.775639e-01 0.751 0 0
Nef and signal transduction R-HSA-164944 2.223362e-01 0.653 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.116348e-01 0.674 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.556235e-01 0.592 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.223362e-01 0.653 0 0
Potential therapeutics for SARS R-HSA-9679191 2.260370e-01 0.646 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.359675e-01 0.627 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.428699e-01 0.615 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.278745e-01 0.642 0 0
SARS-CoV Infections R-HSA-9679506 1.777376e-01 0.750 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.371973e-01 0.625 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 1.932415e-01 0.714 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.563761e-01 0.591 0 0
Death Receptor Signaling R-HSA-73887 2.570880e-01 0.590 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 2.584597e-01 0.588 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.584597e-01 0.588 0 0
Recycling of eIF2:GDP R-HSA-72731 2.584597e-01 0.588 0 0
Disinhibition of SNARE formation R-HSA-114516 2.584597e-01 0.588 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.584597e-01 0.588 0 0
CHL1 interactions R-HSA-447041 2.584597e-01 0.588 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.584597e-01 0.588 0 0
HDL assembly R-HSA-8963896 2.617843e-01 0.582 0 0
Platelet calcium homeostasis R-HSA-418360 2.641015e-01 0.578 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 3.254870e-01 0.487 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.254870e-01 0.487 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.254870e-01 0.487 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.254870e-01 0.487 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.254870e-01 0.487 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.254870e-01 0.487 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.887326e-01 0.410 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 3.887326e-01 0.410 0 0
Type I hemidesmosome assembly R-HSA-446107 2.946482e-01 0.531 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.305724e-01 0.481 0 0
ARMS-mediated activation R-HSA-170984 3.305724e-01 0.481 0 0
Lipophagy R-HSA-9613354 3.305724e-01 0.481 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.460513e-01 0.351 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.460513e-01 0.351 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.460513e-01 0.351 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.882069e-01 0.540 0 0
Binding and entry of HIV virion R-HSA-173107 3.659640e-01 0.437 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 3.659640e-01 0.437 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.148138e-01 0.502 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.148138e-01 0.502 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.148138e-01 0.502 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.765155e-01 0.558 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.982445e-01 0.525 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.006070e-01 0.397 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.006070e-01 0.397 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.979983e-01 0.303 0 0
IRS activation R-HSA-74713 4.979983e-01 0.303 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.979983e-01 0.303 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.979983e-01 0.303 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.979983e-01 0.303 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.979983e-01 0.303 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.680344e-01 0.434 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.680344e-01 0.434 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.680344e-01 0.434 0 0
EGFR downregulation R-HSA-182971 3.015063e-01 0.521 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.421995e-01 0.466 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 4.343310e-01 0.362 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.343310e-01 0.362 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.343310e-01 0.362 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.944068e-01 0.404 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.850204e-01 0.545 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.186635e-01 0.497 0 0
Recycling pathway of L1 R-HSA-437239 3.002871e-01 0.522 0 0
Regulation of signaling by CBL R-HSA-912631 4.204804e-01 0.376 0 0
Polymerase switching R-HSA-69091 4.670037e-01 0.331 0 0
Leading Strand Synthesis R-HSA-69109 4.670037e-01 0.331 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.670037e-01 0.331 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.529698e-01 0.452 0 0
HIV Transcription Initiation R-HSA-167161 3.529698e-01 0.452 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.529698e-01 0.452 0 0
RAF activation R-HSA-5673000 3.781233e-01 0.422 0 0
Dual incision in TC-NER R-HSA-6782135 3.265504e-01 0.486 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.082389e-01 0.389 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.082389e-01 0.389 0 0
Transcription of the HIV genome R-HSA-167172 3.352006e-01 0.475 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.875316e-01 0.412 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.300099e-01 0.367 0 0
HIV elongation arrest and recovery R-HSA-167287 4.300099e-01 0.367 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.300099e-01 0.367 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.300099e-01 0.367 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.985258e-01 0.302 0 0
Formation of axial mesoderm R-HSA-9796292 4.985258e-01 0.302 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.713822e-01 0.327 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.713822e-01 0.327 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.515613e-01 0.345 0 0
mRNA Capping R-HSA-72086 4.515613e-01 0.345 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.220724e-01 0.375 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.728415e-01 0.325 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.728415e-01 0.325 0 0
Activation of the pre-replicative complex R-HSA-68962 4.728415e-01 0.325 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.960641e-01 0.304 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.960641e-01 0.304 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.960641e-01 0.304 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.288259e-01 0.277 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.732939e-01 0.325 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.311727e-01 0.365 0 0
HIV Transcription Elongation R-HSA-167169 4.918336e-01 0.308 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.918336e-01 0.308 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.918336e-01 0.308 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.076627e-01 0.294 0 0
PKR-mediated signaling R-HSA-9833482 3.679983e-01 0.434 0 0
Nucleotide Excision Repair R-HSA-5696398 2.680365e-01 0.572 0 0
Aggrephagy R-HSA-9646399 3.186635e-01 0.497 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.300099e-01 0.367 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.515613e-01 0.345 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.918336e-01 0.308 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.918336e-01 0.308 0 0
Signaling by EGFR R-HSA-177929 4.417737e-01 0.355 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.461650e-01 0.351 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.199185e-01 0.377 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.305724e-01 0.481 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.515613e-01 0.345 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 4.460513e-01 0.351 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.882069e-01 0.540 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.659640e-01 0.437 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.529698e-01 0.452 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.960641e-01 0.304 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.680344e-01 0.434 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 5.201532e-01 0.284 0 0
DNA strand elongation R-HSA-69190 5.144062e-01 0.289 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.765155e-01 0.558 0 0
Trafficking of AMPA receptors R-HSA-399719 3.015063e-01 0.521 0 0
Translesion Synthesis by POLH R-HSA-110320 4.204804e-01 0.376 0 0
Budding and maturation of HIV virion R-HSA-162588 4.938037e-01 0.306 0 0
Prolonged ERK activation events R-HSA-169893 3.148138e-01 0.502 0 0
Interleukin-2 signaling R-HSA-9020558 4.006070e-01 0.397 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 4.670037e-01 0.331 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.082389e-01 0.389 0 0
Ion homeostasis R-HSA-5578775 2.979717e-01 0.526 0 0
Interleukin-6 signaling R-HSA-1059683 4.985258e-01 0.302 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.960641e-01 0.304 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.946482e-01 0.531 0 0
Calcineurin activates NFAT R-HSA-2025928 3.305724e-01 0.481 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.979983e-01 0.303 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 4.979983e-01 0.303 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.979983e-01 0.303 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.343310e-01 0.362 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.343310e-01 0.362 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.343310e-01 0.362 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 3.944068e-01 0.404 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.204804e-01 0.376 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.312876e-01 0.480 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 2.961444e-01 0.528 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.101286e-01 0.292 0 0
Translation R-HSA-72766 4.179750e-01 0.379 0 0
Signal transduction by L1 R-HSA-445144 4.461650e-01 0.351 0 0
Circadian clock R-HSA-9909396 2.944091e-01 0.531 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.985258e-01 0.302 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.898697e-01 0.409 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.555747e-01 0.449 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.555747e-01 0.449 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.555747e-01 0.449 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.555747e-01 0.449 0 0
Frs2-mediated activation R-HSA-170968 4.985258e-01 0.302 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.938037e-01 0.306 0 0
Inhibition of nitric oxide production R-HSA-9636249 3.887326e-01 0.410 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.148138e-01 0.502 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.979983e-01 0.303 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 4.979983e-01 0.303 0 0
Interferon Signaling R-HSA-913531 4.431169e-01 0.353 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.826844e-01 0.549 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.036069e-01 0.518 0 0
MAPK family signaling cascades R-HSA-5683057 3.986026e-01 0.399 0 0
Activation of SMO R-HSA-5635838 3.148138e-01 0.502 0 0
EPH-Ephrin signaling R-HSA-2682334 4.219479e-01 0.375 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.281499e-01 0.277 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.396520e-01 0.469 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.624196e-01 0.441 0 0
Post NMDA receptor activation events R-HSA-438064 4.717324e-01 0.326 0 0
Signalling to ERK5 R-HSA-198765 3.254870e-01 0.487 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.254870e-01 0.487 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 3.887326e-01 0.410 0 0
MET interacts with TNS proteins R-HSA-8875513 3.887326e-01 0.410 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.305724e-01 0.481 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.305724e-01 0.481 0 0
Unwinding of DNA R-HSA-176974 3.305724e-01 0.481 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.305724e-01 0.481 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.460513e-01 0.351 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.148138e-01 0.502 0 0
Bicarbonate transporters R-HSA-425381 4.006070e-01 0.397 0 0
Reelin signalling pathway R-HSA-8866376 4.979983e-01 0.303 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.979983e-01 0.303 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.979983e-01 0.303 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.015063e-01 0.521 0 0
ERKs are inactivated R-HSA-202670 4.343310e-01 0.362 0 0
PKA activation R-HSA-163615 3.944068e-01 0.404 0 0
PKA activation in glucagon signalling R-HSA-164378 3.944068e-01 0.404 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 4.204804e-01 0.376 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.985258e-01 0.302 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.918336e-01 0.308 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.311017e-01 0.365 0 0
Signaling by NOTCH1 R-HSA-1980143 3.168934e-01 0.499 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.482282e-01 0.349 0 0
Surfactant metabolism R-HSA-5683826 4.048211e-01 0.393 0 0
ABC-family proteins mediated transport R-HSA-382556 5.315854e-01 0.274 0 0
Heme signaling R-HSA-9707616 3.848677e-01 0.415 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.414653e-01 0.467 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.659640e-01 0.437 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.281499e-01 0.277 0 0
Platelet degranulation R-HSA-114608 4.271033e-01 0.369 0 0
PLC beta mediated events R-HSA-112043 3.701985e-01 0.432 0 0
Rap1 signalling R-HSA-392517 4.204804e-01 0.376 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 4.670037e-01 0.331 0 0
Rab regulation of trafficking R-HSA-9007101 5.256204e-01 0.279 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.944068e-01 0.404 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.691126e-01 0.570 0 0
Signaling by PTK6 R-HSA-8848021 2.691126e-01 0.570 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.849062e-01 0.545 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.979983e-01 0.303 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.849062e-01 0.545 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.343310e-01 0.362 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.281499e-01 0.277 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.281499e-01 0.277 0 0
Generic Transcription Pathway R-HSA-212436 3.741683e-01 0.427 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.555747e-01 0.449 0 0
Signaling by FGFR2 R-HSA-5654738 3.679983e-01 0.434 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.421995e-01 0.466 0 0
Proteasome assembly R-HSA-9907900 4.048211e-01 0.393 0 0
G-protein mediated events R-HSA-112040 4.581691e-01 0.339 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.460513e-01 0.351 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.700185e-01 0.569 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.396520e-01 0.469 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.918336e-01 0.308 0 0
Signaling by NTRKs R-HSA-166520 3.723010e-01 0.429 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.249895e-01 0.372 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.249895e-01 0.372 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.515613e-01 0.345 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.857929e-01 0.314 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.068283e-01 0.295 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.699477e-01 0.569 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.946482e-01 0.531 0 0
Protein hydroxylation R-HSA-9629569 4.461650e-01 0.351 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.165354e-01 0.380 0 0
Basigin interactions R-HSA-210991 4.713822e-01 0.327 0 0
Hedgehog 'on' state R-HSA-5632684 5.156156e-01 0.288 0 0
Histamine receptors R-HSA-390650 3.887326e-01 0.410 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.946482e-01 0.531 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.659640e-01 0.437 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.356092e-01 0.361 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.288259e-01 0.277 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.686834e-01 0.433 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.201532e-01 0.284 0 0
Regulated Necrosis R-HSA-5218859 3.352006e-01 0.475 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.121941e-01 0.506 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.732939e-01 0.325 0 0
Sodium/Proton exchangers R-HSA-425986 2.946482e-01 0.531 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.460513e-01 0.351 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.659640e-01 0.437 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.979983e-01 0.303 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.979983e-01 0.303 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.985258e-01 0.302 0 0
Regulation of KIT signaling R-HSA-1433559 5.288259e-01 0.277 0 0
FLT3 Signaling R-HSA-9607240 3.357667e-01 0.474 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.201659e-01 0.495 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.670037e-01 0.331 0 0
Diseases of DNA repair R-HSA-9675135 4.392543e-01 0.357 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.946482e-01 0.531 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.946482e-01 0.531 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.305724e-01 0.481 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.979983e-01 0.303 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.461650e-01 0.351 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.507362e-01 0.455 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.938037e-01 0.306 0 0
Metal ion SLC transporters R-HSA-425410 4.732925e-01 0.325 0 0
Tandem pore domain potassium channels R-HSA-1296346 3.659640e-01 0.437 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.343310e-01 0.362 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.960641e-01 0.304 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 4.979983e-01 0.303 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.713822e-01 0.327 0 0
SLC transporter disorders R-HSA-5619102 4.574531e-01 0.340 0 0
Signal regulatory protein family interactions R-HSA-391160 5.288259e-01 0.277 0 0
Selenoamino acid metabolism R-HSA-2408522 5.237780e-01 0.281 0 0
Nephrin family interactions R-HSA-373753 4.461650e-01 0.351 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 4.732939e-01 0.325 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 2.982445e-01 0.525 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.340697e-01 0.272 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.346117e-01 0.272 0 0
Integrin signaling R-HSA-354192 5.346117e-01 0.272 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.346117e-01 0.272 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.346117e-01 0.272 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.346117e-01 0.272 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.386740e-01 0.269 0 0
Integration of energy metabolism R-HSA-163685 5.409572e-01 0.267 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.435710e-01 0.265 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.436015e-01 0.265 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.436015e-01 0.265 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.436015e-01 0.265 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.436015e-01 0.265 0 0
Formation of the ureteric bud R-HSA-9830674 5.436015e-01 0.265 0 0
Syndecan interactions R-HSA-3000170 5.436015e-01 0.265 0 0
TRAIL signaling R-HSA-75158 5.450768e-01 0.264 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.450768e-01 0.264 0 0
Plus-strand DNA synthesis R-HSA-164525 5.450768e-01 0.264 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.450768e-01 0.264 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.450768e-01 0.264 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.450768e-01 0.264 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.450768e-01 0.264 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.450768e-01 0.264 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.450768e-01 0.264 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.450768e-01 0.264 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.450768e-01 0.264 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.450768e-01 0.264 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.450768e-01 0.264 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.450768e-01 0.264 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.450768e-01 0.264 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.450768e-01 0.264 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.458713e-01 0.263 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.488925e-01 0.261 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.543878e-01 0.256 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.543878e-01 0.256 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.551130e-01 0.256 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.562277e-01 0.255 0 0
Signaling by NOTCH4 R-HSA-9013694 5.573065e-01 0.254 0 0
Signaling by FGFR in disease R-HSA-1226099 5.573065e-01 0.254 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.578559e-01 0.253 0 0
Translesion synthesis by REV1 R-HSA-110312 5.578559e-01 0.253 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.578559e-01 0.253 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.578559e-01 0.253 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.578559e-01 0.253 0 0
DCC mediated attractive signaling R-HSA-418885 5.578559e-01 0.253 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.578559e-01 0.253 0 0
Biotin transport and metabolism R-HSA-196780 5.578559e-01 0.253 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.578559e-01 0.253 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 5.632694e-01 0.249 0 0
Signal Transduction R-HSA-162582 5.638888e-01 0.249 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.663696e-01 0.247 0 0
Plasma lipoprotein assembly R-HSA-8963898 5.663696e-01 0.247 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.671903e-01 0.246 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.708637e-01 0.243 0 0
Dual Incision in GG-NER R-HSA-5696400 5.737062e-01 0.241 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.737062e-01 0.241 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.737062e-01 0.241 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.792954e-01 0.237 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.792954e-01 0.237 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.803231e-01 0.236 0 0
G1 Phase R-HSA-69236 5.803231e-01 0.236 0 0
Cyclin D associated events in G1 R-HSA-69231 5.803231e-01 0.236 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.803231e-01 0.236 0 0
Neutrophil degranulation R-HSA-6798695 5.820299e-01 0.235 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.837500e-01 0.234 0 0
Adipogenesis R-HSA-9843745 5.850128e-01 0.233 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.855876e-01 0.232 0 0
Translesion synthesis by POLI R-HSA-5656121 5.855876e-01 0.232 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.855876e-01 0.232 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.855876e-01 0.232 0 0
Negative regulation of FLT3 R-HSA-9706369 5.855876e-01 0.232 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.877426e-01 0.231 0 0
Signaling by LTK in cancer R-HSA-9842640 5.877426e-01 0.231 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.877426e-01 0.231 0 0
Uncoating of the HIV Virion R-HSA-162585 5.877426e-01 0.231 0 0
Abacavir transmembrane transport R-HSA-2161517 5.877426e-01 0.231 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.877426e-01 0.231 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 5.877426e-01 0.231 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.877426e-01 0.231 0 0
Long-term potentiation R-HSA-9620244 5.884263e-01 0.230 0 0
TGFBR3 expression R-HSA-9839394 5.884263e-01 0.230 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.884263e-01 0.230 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 5.884263e-01 0.230 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 5.884263e-01 0.230 0 0
Signalling to ERKs R-HSA-187687 5.925430e-01 0.227 0 0
PERK regulates gene expression R-HSA-381042 5.925430e-01 0.227 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 5.970140e-01 0.224 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.970140e-01 0.224 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.970140e-01 0.224 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 5.970140e-01 0.224 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.970140e-01 0.224 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.970728e-01 0.224 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.072114e-01 0.217 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.097479e-01 0.215 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.097479e-01 0.215 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.097479e-01 0.215 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.120092e-01 0.213 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.120092e-01 0.213 0 0
Translesion synthesis by POLK R-HSA-5655862 6.120092e-01 0.213 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.120092e-01 0.213 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 6.120092e-01 0.213 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.120092e-01 0.213 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.133260e-01 0.212 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.186967e-01 0.209 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.196678e-01 0.208 0 0
SOS-mediated signalling R-HSA-112412 6.264093e-01 0.203 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.264093e-01 0.203 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.264093e-01 0.203 0 0
PTK6 Expression R-HSA-8849473 6.264093e-01 0.203 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.264093e-01 0.203 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.264093e-01 0.203 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.264093e-01 0.203 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.264093e-01 0.203 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.286948e-01 0.202 0 0
Degradation of DVL R-HSA-4641258 6.286948e-01 0.202 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.292453e-01 0.201 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.300095e-01 0.201 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.300095e-01 0.201 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.300095e-01 0.201 0 0
Signaling by FGFR R-HSA-190236 6.300095e-01 0.201 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 6.303172e-01 0.200 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 6.308691e-01 0.200 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.371224e-01 0.196 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.371224e-01 0.196 0 0
Signaling by Hippo R-HSA-2028269 6.371224e-01 0.196 0 0
Specification of primordial germ cells R-HSA-9827857 6.371224e-01 0.196 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.433924e-01 0.192 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.459807e-01 0.190 0 0
Pyroptosis R-HSA-5620971 6.501231e-01 0.187 0 0
Hedgehog 'off' state R-HSA-5610787 6.520940e-01 0.186 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.555633e-01 0.183 0 0
Signaling by ERBB2 R-HSA-1227986 6.588999e-01 0.181 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.590564e-01 0.181 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.598618e-01 0.181 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.598618e-01 0.181 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.609402e-01 0.180 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.609402e-01 0.180 0 0
GAB1 signalosome R-HSA-180292 6.609402e-01 0.180 0 0
Ephrin signaling R-HSA-3928664 6.609402e-01 0.180 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.609402e-01 0.180 0 0
Polo-like kinase mediated events R-HSA-156711 6.609402e-01 0.180 0 0
Platelet sensitization by LDL R-HSA-432142 6.609402e-01 0.180 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.614514e-01 0.180 0 0
Minus-strand DNA synthesis R-HSA-164516 6.614514e-01 0.180 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 6.614514e-01 0.180 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.614514e-01 0.180 0 0
Formation of annular gap junctions R-HSA-196025 6.614514e-01 0.180 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.614514e-01 0.180 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.614514e-01 0.180 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.614514e-01 0.180 0 0
Interleukin-9 signaling R-HSA-8985947 6.614514e-01 0.180 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 6.614514e-01 0.180 0 0
Interleukin-23 signaling R-HSA-9020933 6.614514e-01 0.180 0 0
Regulation by c-FLIP R-HSA-3371378 6.614514e-01 0.180 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 6.614514e-01 0.180 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.614514e-01 0.180 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.614514e-01 0.180 0 0
Dimerization of procaspase-8 R-HSA-69416 6.614514e-01 0.180 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.614514e-01 0.180 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.614514e-01 0.180 0 0
Nucleotide salvage defects R-HSA-9734207 6.614514e-01 0.180 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.614514e-01 0.180 0 0
Adrenoceptors R-HSA-390696 6.614514e-01 0.180 0 0
Signaling by Hedgehog R-HSA-5358351 6.618805e-01 0.179 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 6.627259e-01 0.179 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.627259e-01 0.179 0 0
Signaling by ALK R-HSA-201556 6.627259e-01 0.179 0 0
Stabilization of p53 R-HSA-69541 6.627259e-01 0.179 0 0
Interleukin-1 signaling R-HSA-9020702 6.628554e-01 0.179 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.691596e-01 0.174 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.691596e-01 0.174 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.745420e-01 0.171 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.789236e-01 0.168 0 0
Diseases of Immune System R-HSA-5260271 6.789236e-01 0.168 0 0
The NLRP3 inflammasome R-HSA-844456 6.834847e-01 0.165 0 0
Maturation of nucleoprotein R-HSA-9694631 6.834847e-01 0.165 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.874260e-01 0.163 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.874260e-01 0.163 0 0
Interleukin-37 signaling R-HSA-9008059 6.874260e-01 0.163 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.887955e-01 0.162 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.932084e-01 0.159 0 0
Gap junction degradation R-HSA-190873 6.932084e-01 0.159 0 0
WNT mediated activation of DVL R-HSA-201688 6.932084e-01 0.159 0 0
CASP8 activity is inhibited R-HSA-5218900 6.932084e-01 0.159 0 0
Interleukin-21 signaling R-HSA-9020958 6.932084e-01 0.159 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.932084e-01 0.159 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.932084e-01 0.159 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.932084e-01 0.159 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.932084e-01 0.159 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.932084e-01 0.159 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.932084e-01 0.159 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.932084e-01 0.159 0 0
Interleukin-1 processing R-HSA-448706 6.932084e-01 0.159 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.932084e-01 0.159 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 6.932084e-01 0.159 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.945701e-01 0.158 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.945701e-01 0.158 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.945701e-01 0.158 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.945701e-01 0.158 0 0
MHC class II antigen presentation R-HSA-2132295 6.951165e-01 0.158 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.983771e-01 0.156 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.999984e-01 0.155 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.026184e-01 0.153 0 0
Orc1 removal from chromatin R-HSA-68949 7.026184e-01 0.153 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.026184e-01 0.153 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.039169e-01 0.152 0 0
RSV-host interactions R-HSA-9833110 7.039298e-01 0.152 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.047851e-01 0.152 0 0
Negative regulation of MET activity R-HSA-6807004 7.047851e-01 0.152 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 7.049255e-01 0.152 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.049255e-01 0.152 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.096638e-01 0.149 0 0
Intra-Golgi traffic R-HSA-6811438 7.096638e-01 0.149 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.096638e-01 0.149 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.160084e-01 0.145 0 0
Signaling by WNT in cancer R-HSA-4791275 7.216649e-01 0.142 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.216649e-01 0.142 0 0
Regulation of CDH11 function R-HSA-9762292 7.219883e-01 0.141 0 0
PI3K/AKT activation R-HSA-198203 7.219883e-01 0.141 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.219883e-01 0.141 0 0
DNA replication initiation R-HSA-68952 7.219883e-01 0.141 0 0
CASP4 inflammasome assembly R-HSA-9948001 7.219883e-01 0.141 0 0
Signal attenuation R-HSA-74749 7.219883e-01 0.141 0 0
Interleukin-27 signaling R-HSA-9020956 7.219883e-01 0.141 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.219883e-01 0.141 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.219883e-01 0.141 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.219883e-01 0.141 0 0
Pexophagy R-HSA-9664873 7.219883e-01 0.141 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.219883e-01 0.141 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.219883e-01 0.141 0 0
Signaling by Leptin R-HSA-2586552 7.219883e-01 0.141 0 0
Formation of apoptosome R-HSA-111458 7.219883e-01 0.141 0 0
Cellular response to hypoxia R-HSA-1234174 7.229302e-01 0.141 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.242057e-01 0.140 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.246376e-01 0.140 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.248764e-01 0.140 0 0
Lagging Strand Synthesis R-HSA-69186 7.248764e-01 0.140 0 0
G-protein activation R-HSA-202040 7.248764e-01 0.140 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.248764e-01 0.140 0 0
ERK/MAPK targets R-HSA-198753 7.248764e-01 0.140 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.267996e-01 0.139 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.300028e-01 0.137 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.375513e-01 0.132 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.376544e-01 0.132 0 0
Cardiogenesis R-HSA-9733709 7.376544e-01 0.132 0 0
Signaling by FGFR4 R-HSA-5654743 7.381986e-01 0.132 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.381986e-01 0.132 0 0
Signaling by Interleukins R-HSA-449147 7.387635e-01 0.131 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.417105e-01 0.130 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.437979e-01 0.129 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.437979e-01 0.129 0 0
Ribavirin ADME R-HSA-9755088 7.437979e-01 0.129 0 0
ER-Phagosome pathway R-HSA-1236974 7.469961e-01 0.127 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.480699e-01 0.126 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.480699e-01 0.126 0 0
vRNP Assembly R-HSA-192905 7.480699e-01 0.126 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 7.480699e-01 0.126 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.480699e-01 0.126 0 0
Suppression of apoptosis R-HSA-9635465 7.480699e-01 0.126 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.480699e-01 0.126 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.480699e-01 0.126 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.506274e-01 0.125 0 0
Netrin-1 signaling R-HSA-373752 7.516474e-01 0.124 0 0
Toll-like Receptor Cascades R-HSA-168898 7.528842e-01 0.123 0 0
Vpu mediated degradation of CD4 R-HSA-180534 7.529069e-01 0.123 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 7.535815e-01 0.123 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.535815e-01 0.123 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.571309e-01 0.121 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.571309e-01 0.121 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.588117e-01 0.120 0 0
tRNA processing R-HSA-72306 7.598074e-01 0.119 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.613912e-01 0.118 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.615923e-01 0.118 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.640997e-01 0.117 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 7.645586e-01 0.117 0 0
Signaling by FGFR3 R-HSA-5654741 7.645586e-01 0.117 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.645586e-01 0.117 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.645586e-01 0.117 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 7.674377e-01 0.115 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.674377e-01 0.115 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.674377e-01 0.115 0 0
Signaling by NOTCH2 R-HSA-1980145 7.674377e-01 0.115 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.710726e-01 0.113 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.717060e-01 0.113 0 0
NF-kB is activated and signals survival R-HSA-209560 7.717060e-01 0.113 0 0
Plasmalogen biosynthesis R-HSA-75896 7.717060e-01 0.113 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.717060e-01 0.113 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.717060e-01 0.113 0 0
Activation of RAC1 R-HSA-428540 7.717060e-01 0.113 0 0
Sodium/Calcium exchangers R-HSA-425561 7.717060e-01 0.113 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.764886e-01 0.110 0 0
Signaling by TGFBR3 R-HSA-9839373 7.769401e-01 0.110 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.769401e-01 0.110 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.769401e-01 0.110 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.780698e-01 0.109 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.780698e-01 0.109 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.783045e-01 0.109 0 0
Interleukin-20 family signaling R-HSA-8854691 7.783045e-01 0.109 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 7.783045e-01 0.109 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.783045e-01 0.109 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.812639e-01 0.107 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.812639e-01 0.107 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.812639e-01 0.107 0 0
Regulation of Apoptosis R-HSA-169911 7.812639e-01 0.107 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.841662e-01 0.106 0 0
Protein folding R-HSA-391251 7.841975e-01 0.106 0 0
Extension of Telomeres R-HSA-180786 7.873122e-01 0.104 0 0
Post-translational protein modification R-HSA-597592 7.900362e-01 0.102 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.920204e-01 0.101 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 7.931259e-01 0.101 0 0
Interleukin-15 signaling R-HSA-8983432 7.931259e-01 0.101 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.931259e-01 0.101 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.931259e-01 0.101 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.931259e-01 0.101 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.931259e-01 0.101 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.931259e-01 0.101 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.931259e-01 0.101 0 0
Signaling by LTK R-HSA-9842663 7.931259e-01 0.101 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.931259e-01 0.101 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.931259e-01 0.101 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.931259e-01 0.101 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.931259e-01 0.101 0 0
Interleukin-35 Signalling R-HSA-8984722 7.931259e-01 0.101 0 0
OAS antiviral response R-HSA-8983711 7.931259e-01 0.101 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.931259e-01 0.101 0 0
Deadenylation of mRNA R-HSA-429947 7.939808e-01 0.100 0 0
Interleukin-6 family signaling R-HSA-6783589 7.939808e-01 0.100 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.944043e-01 0.100 0 0
FLT3 signaling in disease R-HSA-9682385 7.944043e-01 0.100 0 0
Triglyceride catabolism R-HSA-163560 7.944043e-01 0.100 0 0
RET signaling R-HSA-8853659 7.944043e-01 0.100 0 0
FGFR2 mutant receptor activation R-HSA-1839126 7.944043e-01 0.100 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.961040e-01 0.099 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.976636e-01 0.098 0 0
GPER1 signaling R-HSA-9634597 8.001518e-01 0.097 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.001518e-01 0.097 0 0
Co-stimulation by CD28 R-HSA-389356 8.001518e-01 0.097 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.068791e-01 0.093 0 0
Degradation of AXIN R-HSA-4641257 8.068791e-01 0.093 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.068791e-01 0.093 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.070993e-01 0.093 0 0
Aquaporin-mediated transport R-HSA-445717 8.077299e-01 0.093 0 0
MAP kinase activation R-HSA-450294 8.077299e-01 0.093 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.086684e-01 0.092 0 0
Interleukin-7 signaling R-HSA-1266695 8.086684e-01 0.092 0 0
G1/S Transition R-HSA-69206 8.104407e-01 0.091 0 0
Degradation of CDH1 R-HSA-9766229 8.110037e-01 0.091 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.125371e-01 0.090 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.125371e-01 0.090 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.125371e-01 0.090 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.125371e-01 0.090 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.125371e-01 0.090 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.125371e-01 0.090 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.125371e-01 0.090 0 0
Processing of SMDT1 R-HSA-8949664 8.125371e-01 0.090 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.125371e-01 0.090 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.125371e-01 0.090 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.125371e-01 0.090 0 0
Maturation of nucleoprotein R-HSA-9683610 8.125371e-01 0.090 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.125371e-01 0.090 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.125371e-01 0.090 0 0
Mitochondrial protein import R-HSA-1268020 8.173383e-01 0.088 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.173383e-01 0.088 0 0
MET promotes cell motility R-HSA-8875878 8.187094e-01 0.087 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.224149e-01 0.085 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.224149e-01 0.085 0 0
Myogenesis R-HSA-525793 8.224149e-01 0.085 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.224149e-01 0.085 0 0
Abacavir ADME R-HSA-2161522 8.224149e-01 0.085 0 0
TRP channels R-HSA-3295583 8.224149e-01 0.085 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.264648e-01 0.083 0 0
Removal of the Flap Intermediate R-HSA-69166 8.301281e-01 0.081 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.301281e-01 0.081 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.301281e-01 0.081 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.301281e-01 0.081 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.301281e-01 0.081 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.301281e-01 0.081 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.301281e-01 0.081 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.301281e-01 0.081 0 0
Malate-aspartate shuttle R-HSA-9856872 8.301281e-01 0.081 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.301281e-01 0.081 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.301281e-01 0.081 0 0
Zinc transporters R-HSA-435354 8.301281e-01 0.081 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.301281e-01 0.081 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.312600e-01 0.080 0 0
The phototransduction cascade R-HSA-2514856 8.312600e-01 0.080 0 0
Adaptive Immune System R-HSA-1280218 8.316932e-01 0.080 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.332193e-01 0.079 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.332193e-01 0.079 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.352675e-01 0.078 0 0
Cristae formation R-HSA-8949613 8.352675e-01 0.078 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.352675e-01 0.078 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.352675e-01 0.078 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.405245e-01 0.075 0 0
Interleukin-2 family signaling R-HSA-451927 8.405245e-01 0.075 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.405245e-01 0.075 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.460693e-01 0.073 0 0
Erythropoietin activates RAS R-HSA-9027284 8.460693e-01 0.073 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.460693e-01 0.073 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.460693e-01 0.073 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.460693e-01 0.073 0 0
Protein lipoylation R-HSA-9857492 8.460693e-01 0.073 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.460693e-01 0.073 0 0
p75NTR signals via NF-kB R-HSA-193639 8.460693e-01 0.073 0 0
p38MAPK events R-HSA-171007 8.460693e-01 0.073 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.460693e-01 0.073 0 0
DNA Damage Reversal R-HSA-73942 8.460693e-01 0.073 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.460693e-01 0.073 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.460693e-01 0.073 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.460693e-01 0.073 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.460693e-01 0.073 0 0
FOXO-mediated transcription R-HSA-9614085 8.461934e-01 0.073 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.468516e-01 0.072 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.469279e-01 0.072 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.472728e-01 0.072 0 0
Telomere Extension By Telomerase R-HSA-171319 8.472728e-01 0.072 0 0
Inflammasomes R-HSA-622312 8.472728e-01 0.072 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.472728e-01 0.072 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.505545e-01 0.070 0 0
Interleukin-1 family signaling R-HSA-446652 8.523550e-01 0.069 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.534614e-01 0.069 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.584767e-01 0.066 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.600302e-01 0.065 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.600302e-01 0.065 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.600302e-01 0.065 0 0
Killing mechanisms R-HSA-9664420 8.605154e-01 0.065 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.605154e-01 0.065 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.605154e-01 0.065 0 0
Fructose catabolism R-HSA-70350 8.605154e-01 0.065 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.605154e-01 0.065 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.605154e-01 0.065 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.605154e-01 0.065 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.605154e-01 0.065 0 0
Attachment and Entry R-HSA-9678110 8.605154e-01 0.065 0 0
Atorvastatin ADME R-HSA-9754706 8.605154e-01 0.065 0 0
G alpha (z) signalling events R-HSA-418597 8.663579e-01 0.062 0 0
Signaling by NOTCH3 R-HSA-9012852 8.663579e-01 0.062 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.689237e-01 0.061 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.689237e-01 0.061 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.689744e-01 0.061 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.736065e-01 0.059 0 0
Glycine degradation R-HSA-6783984 8.736065e-01 0.059 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.736065e-01 0.059 0 0
Heme assimilation R-HSA-9927020 8.736065e-01 0.059 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.736065e-01 0.059 0 0
Passive transport by Aquaporins R-HSA-432047 8.736065e-01 0.059 0 0
Synthesis of PG R-HSA-1483148 8.736065e-01 0.059 0 0
Coenzyme A biosynthesis R-HSA-196783 8.736065e-01 0.059 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.736065e-01 0.059 0 0
Signaling by FGFR1 R-HSA-5654736 8.740865e-01 0.058 0 0
TNF signaling R-HSA-75893 8.740865e-01 0.058 0 0
Downstream signal transduction R-HSA-186763 8.786573e-01 0.056 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.786573e-01 0.056 0 0
COPII-mediated vesicle transport R-HSA-204005 8.809494e-01 0.055 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 8.809494e-01 0.055 0 0
Interleukin-17 signaling R-HSA-448424 8.809494e-01 0.055 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.823678e-01 0.054 0 0
Amine ligand-binding receptors R-HSA-375280 8.853597e-01 0.053 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.854697e-01 0.053 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.854697e-01 0.053 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.854697e-01 0.053 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.854697e-01 0.053 0 0
Choline catabolism R-HSA-6798163 8.854697e-01 0.053 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.854697e-01 0.053 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.854697e-01 0.053 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.854697e-01 0.053 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.854697e-01 0.053 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.877192e-01 0.052 0 0
Signaling by TGFB family members R-HSA-9006936 8.905429e-01 0.050 0 0
Somitogenesis R-HSA-9824272 8.928457e-01 0.049 0 0
Platelet homeostasis R-HSA-418346 8.931223e-01 0.049 0 0
Regulation of beta-cell development R-HSA-186712 8.949945e-01 0.048 0 0
Triglyceride metabolism R-HSA-8979227 8.949945e-01 0.048 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.949945e-01 0.048 0 0
G-protein beta:gamma signalling R-HSA-397795 8.961498e-01 0.048 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.961498e-01 0.048 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.961498e-01 0.048 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.962200e-01 0.048 0 0
Nephron development R-HSA-9831926 8.962200e-01 0.048 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.962200e-01 0.048 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.962200e-01 0.048 0 0
Mismatch Repair R-HSA-5358508 8.962200e-01 0.048 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.994679e-01 0.046 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.994679e-01 0.046 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.007529e-01 0.045 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.008438e-01 0.045 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.012527e-01 0.045 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.039878e-01 0.044 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.039878e-01 0.044 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.039878e-01 0.044 0 0
Signaling by ERBB4 R-HSA-1236394 9.049433e-01 0.043 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.059619e-01 0.043 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.059619e-01 0.043 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.059619e-01 0.043 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.059619e-01 0.043 0 0
Diseases of hemostasis R-HSA-9671793 9.059619e-01 0.043 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.059619e-01 0.043 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.059619e-01 0.043 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.059619e-01 0.043 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.059619e-01 0.043 0 0
Other interleukin signaling R-HSA-449836 9.059619e-01 0.043 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.059619e-01 0.043 0 0
Synthesis of PC R-HSA-1483191 9.065139e-01 0.043 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.065629e-01 0.043 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.070799e-01 0.042 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.071791e-01 0.042 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.071791e-01 0.042 0 0
Regulation of insulin secretion R-HSA-422356 9.102732e-01 0.041 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.112700e-01 0.040 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.112700e-01 0.040 0 0
Cardiac conduction R-HSA-5576891 9.120107e-01 0.040 0 0
Gluconeogenesis R-HSA-70263 9.127382e-01 0.040 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.127876e-01 0.040 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.147898e-01 0.039 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.147898e-01 0.039 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.147898e-01 0.039 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.147898e-01 0.039 0 0
Creatine metabolism R-HSA-71288 9.147898e-01 0.039 0 0
Signaling by NODAL R-HSA-1181150 9.147898e-01 0.039 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.185834e-01 0.037 0 0
Developmental Biology R-HSA-1266738 9.201562e-01 0.036 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.227894e-01 0.035 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.227894e-01 0.035 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.227894e-01 0.035 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.227894e-01 0.035 0 0
Signalling to RAS R-HSA-167044 9.227894e-01 0.035 0 0
Abacavir metabolism R-HSA-2161541 9.227894e-01 0.035 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.227894e-01 0.035 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.227894e-01 0.035 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.227894e-01 0.035 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.240689e-01 0.034 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.243063e-01 0.034 0 0
ABC transporter disorders R-HSA-5619084 9.246052e-01 0.034 0 0
Developmental Cell Lineages R-HSA-9734767 9.253757e-01 0.034 0 0
PI Metabolism R-HSA-1483255 9.269789e-01 0.033 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.292137e-01 0.032 0 0
Serine metabolism R-HSA-977347 9.300385e-01 0.031 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.300385e-01 0.031 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.300385e-01 0.031 0 0
Attachment and Entry R-HSA-9694614 9.300385e-01 0.031 0 0
Assembly Of The HIV Virion R-HSA-175474 9.300385e-01 0.031 0 0
Signaling by MET R-HSA-6806834 9.330116e-01 0.030 0 0
Kidney development R-HSA-9830369 9.365326e-01 0.028 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.365326e-01 0.028 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.366073e-01 0.028 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.366073e-01 0.028 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.366073e-01 0.028 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.366073e-01 0.028 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.366073e-01 0.028 0 0
LDL clearance R-HSA-8964038 9.366073e-01 0.028 0 0
Fructose metabolism R-HSA-5652084 9.366073e-01 0.028 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.368921e-01 0.028 0 0
Cellular response to chemical stress R-HSA-9711123 9.371890e-01 0.028 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.385540e-01 0.028 0 0
Pentose phosphate pathway R-HSA-71336 9.405183e-01 0.027 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.425598e-01 0.026 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.425598e-01 0.026 0 0
Biosynthesis of maresins R-HSA-9018682 9.425598e-01 0.026 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.425598e-01 0.026 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.425598e-01 0.026 0 0
Carnitine shuttle R-HSA-200425 9.425598e-01 0.026 0 0
Growth hormone receptor signaling R-HSA-982772 9.425598e-01 0.026 0 0
Mitochondrial biogenesis R-HSA-1592230 9.436286e-01 0.025 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.440531e-01 0.025 0 0
Generation of second messenger molecules R-HSA-202433 9.451466e-01 0.025 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.457104e-01 0.024 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.467424e-01 0.024 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.477946e-01 0.023 0 0
CYP2E1 reactions R-HSA-211999 9.479536e-01 0.023 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.479536e-01 0.023 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.479536e-01 0.023 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.479536e-01 0.023 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.479536e-01 0.023 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.479536e-01 0.023 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.483168e-01 0.023 0 0
Maturation of spike protein R-HSA-9694548 9.494305e-01 0.023 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.528412e-01 0.021 0 0
G protein gated Potassium channels R-HSA-1296059 9.528412e-01 0.021 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.528412e-01 0.021 0 0
Tight junction interactions R-HSA-420029 9.528412e-01 0.021 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.528412e-01 0.021 0 0
Hyaluronan degradation R-HSA-2160916 9.528412e-01 0.021 0 0
Laminin interactions R-HSA-3000157 9.528412e-01 0.021 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.562145e-01 0.019 0 0
Ca2+ pathway R-HSA-4086398 9.571968e-01 0.019 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.572701e-01 0.019 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.572701e-01 0.019 0 0
MET activates PTK2 signaling R-HSA-8874081 9.572701e-01 0.019 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.572701e-01 0.019 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.572701e-01 0.019 0 0
Sphingolipid catabolism R-HSA-9845614 9.572701e-01 0.019 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.586410e-01 0.018 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.601602e-01 0.018 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.604475e-01 0.018 0 0
Signaling by SCF-KIT R-HSA-1433557 9.604475e-01 0.018 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.612833e-01 0.017 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.612833e-01 0.017 0 0
Triglyceride biosynthesis R-HSA-75109 9.612833e-01 0.017 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.612833e-01 0.017 0 0
Synthesis of PE R-HSA-1483213 9.612833e-01 0.017 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.612833e-01 0.017 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.612833e-01 0.017 0 0
Insulin processing R-HSA-264876 9.612833e-01 0.017 0 0
Iron uptake and transport R-HSA-917937 9.625679e-01 0.017 0 0
tRNA Aminoacylation R-HSA-379724 9.629797e-01 0.016 0 0
Metabolism of polyamines R-HSA-351202 9.629797e-01 0.016 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.649198e-01 0.016 0 0
Prednisone ADME R-HSA-9757110 9.649198e-01 0.016 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.649198e-01 0.016 0 0
Pyrimidine salvage R-HSA-73614 9.649198e-01 0.016 0 0
Gastrulation R-HSA-9758941 9.658559e-01 0.015 0 0
Downstream TCR signaling R-HSA-202424 9.659139e-01 0.015 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.660578e-01 0.015 0 0
Translation of Structural Proteins R-HSA-9694635 9.673075e-01 0.014 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.678269e-01 0.014 0 0
Signaling by PDGF R-HSA-186797 9.680645e-01 0.014 0 0
Thyroxine biosynthesis R-HSA-209968 9.682150e-01 0.014 0 0
Signaling by Erythropoietin R-HSA-9006335 9.682150e-01 0.014 0 0
Glucagon-type ligand receptors R-HSA-420092 9.682150e-01 0.014 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.682150e-01 0.014 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.691405e-01 0.014 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.691405e-01 0.014 0 0
Integrin cell surface interactions R-HSA-216083 9.694618e-01 0.013 0 0
Interferon alpha/beta signaling R-HSA-909733 9.696115e-01 0.013 0 0
Complex I biogenesis R-HSA-6799198 9.703522e-01 0.013 0 0
DAP12 signaling R-HSA-2424491 9.712007e-01 0.013 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.712007e-01 0.013 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.712007e-01 0.013 0 0
Neurotransmitter clearance R-HSA-112311 9.712007e-01 0.013 0 0
Activation of BH3-only proteins R-HSA-114452 9.712007e-01 0.013 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.714828e-01 0.013 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.716051e-01 0.013 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.718431e-01 0.012 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.724842e-01 0.012 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.735965e-01 0.012 0 0
Intraflagellar transport R-HSA-5620924 9.738792e-01 0.011 0 0
Cargo concentration in the ER R-HSA-5694530 9.739062e-01 0.011 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.739062e-01 0.011 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.752480e-01 0.011 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.759768e-01 0.011 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.759768e-01 0.011 0 0
Hemostasis R-HSA-109582 9.762418e-01 0.010 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.763577e-01 0.010 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.779110e-01 0.010 0 0
Azathioprine ADME R-HSA-9748787 9.779110e-01 0.010 0 0
Recycling of bile acids and salts R-HSA-159418 9.785790e-01 0.009 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.792011e-01 0.009 0 0
TCR signaling R-HSA-202403 9.801005e-01 0.009 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.805917e-01 0.009 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.805917e-01 0.009 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.805917e-01 0.009 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.805917e-01 0.009 0 0
Heme degradation R-HSA-189483 9.805917e-01 0.009 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.809389e-01 0.008 0 0
Infectious disease R-HSA-5663205 9.809842e-01 0.008 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.813371e-01 0.008 0 0
Signal amplification R-HSA-392518 9.824154e-01 0.008 0 0
eNOS activation R-HSA-203615 9.824154e-01 0.008 0 0
Hyaluronan metabolism R-HSA-2142845 9.824154e-01 0.008 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.824154e-01 0.008 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.824154e-01 0.008 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.824154e-01 0.008 0 0
Metabolism of proteins R-HSA-392499 9.826543e-01 0.008 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.840678e-01 0.007 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.840678e-01 0.007 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.849980e-01 0.007 0 0
GPVI-mediated activation cascade R-HSA-114604 9.855650e-01 0.006 0 0
Glycosphingolipid transport R-HSA-9845576 9.855650e-01 0.006 0 0
G1/S-Specific Transcription R-HSA-69205 9.855650e-01 0.006 0 0
RUNX2 regulates bone development R-HSA-8941326 9.855650e-01 0.006 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.865027e-01 0.006 0 0
Parasite infection R-HSA-9664407 9.865027e-01 0.006 0 0
Leishmania phagocytosis R-HSA-9664417 9.865027e-01 0.006 0 0
Protein localization R-HSA-9609507 9.865063e-01 0.006 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.867103e-01 0.006 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.869217e-01 0.006 0 0
Metabolism of folate and pterines R-HSA-196757 9.869217e-01 0.006 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.871469e-01 0.006 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.881509e-01 0.005 0 0
Purine salvage R-HSA-74217 9.881509e-01 0.005 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.881509e-01 0.005 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.882389e-01 0.005 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.892404e-01 0.005 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.892646e-01 0.005 0 0
RAS processing R-HSA-9648002 9.892646e-01 0.005 0 0
Peroxisomal protein import R-HSA-9033241 9.897186e-01 0.004 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.897186e-01 0.004 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.901240e-01 0.004 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.902737e-01 0.004 0 0
Interferon gamma signaling R-HSA-877300 9.904047e-01 0.004 0 0
RAB geranylgeranylation R-HSA-8873719 9.905649e-01 0.004 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.905851e-01 0.004 0 0
Interleukin-10 signaling R-HSA-6783783 9.905851e-01 0.004 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.913431e-01 0.004 0 0
Nucleotide salvage R-HSA-8956321 9.913431e-01 0.004 0 0
Collagen formation R-HSA-1474290 9.914625e-01 0.004 0 0
Stimuli-sensing channels R-HSA-2672351 9.915076e-01 0.004 0 0
Neuronal System R-HSA-112316 9.918843e-01 0.004 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.920164e-01 0.003 0 0
Translation of Structural Proteins R-HSA-9683701 9.920164e-01 0.003 0 0
Activation of GABAB receptors R-HSA-991365 9.927670e-01 0.003 0 0
GABA B receptor activation R-HSA-977444 9.927670e-01 0.003 0 0
Transmission across Chemical Synapses R-HSA-112315 9.929732e-01 0.003 0 0
IGF1R signaling cascade R-HSA-2428924 9.933197e-01 0.003 0 0
Ion transport by P-type ATPases R-HSA-936837 9.933197e-01 0.003 0 0
Pyrimidine catabolism R-HSA-73621 9.934470e-01 0.003 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.938746e-01 0.003 0 0
DAP12 interactions R-HSA-2172127 9.940632e-01 0.003 0 0
Gap junction trafficking R-HSA-190828 9.940632e-01 0.003 0 0
Methylation R-HSA-156581 9.940632e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.943842e-01 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.945136e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.946214e-01 0.002 0 0
PPARA activates gene expression R-HSA-1989781 9.948383e-01 0.002 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.951272e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.952819e-01 0.002 0 0
G alpha (s) signalling events R-HSA-418555 9.955331e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.956301e-01 0.002 0 0
Leishmania infection R-HSA-9658195 9.956301e-01 0.002 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.960383e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.960405e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.960405e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.963705e-01 0.002 0 0
Gap junction trafficking and regulation R-HSA-157858 9.963768e-01 0.002 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.965912e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.966530e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.966752e-01 0.001 0 0
PI3K Cascade R-HSA-109704 9.967176e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.970264e-01 0.001 0 0
Neddylation R-HSA-8951664 9.971999e-01 0.001 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.974463e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.977824e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.979971e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.980407e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.981856e-01 0.001 0 0
Digestion R-HSA-8935690 9.981856e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.982234e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.982548e-01 0.001 0 0
Immune System R-HSA-168256 9.983431e-01 0.001 0 0
IRS-mediated signalling R-HSA-112399 9.983563e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.983563e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.983563e-01 0.001 0 0
GABA receptor activation R-HSA-977443 9.987781e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.988931e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.990917e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.991616e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.991706e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.991772e-01 0.000 0 0
Insulin receptor signalling cascade R-HSA-74751 9.991772e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.992879e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.993884e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.993884e-01 0.000 0 0
Disease R-HSA-1643685 9.995572e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.995712e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.995756e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.995882e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.995882e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.995882e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.996082e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.996270e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.996621e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.996621e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.996885e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.996940e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.997012e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.997219e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.997507e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.997940e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.997964e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.997988e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.998306e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998417e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.998469e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999077e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999155e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999164e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999207e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999234e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999272e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999279e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999294e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999391e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999431e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999437e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999455e-01 0.000 0 0
Signaling by Insulin receptor R-HSA-74752 9.999577e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999599e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999611e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999716e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999742e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999769e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999808e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999825e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999879e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999900e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999932e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999947e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999950e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999957e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999964e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999969e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999976e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999979e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999983e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999990e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999991e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999991e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999992e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999995e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999997e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999999e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999999e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways