CHK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O00716 S124 EPSD|PSP E2F3 KIAA0075 HGPSSRAGLLQQPPALGRGGsGGGGGPPAKRRLELGESGHQ
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15151 S342 SIGNOR|iPTMNet|EPSD|PSP MDM4 MDMX RCWALRKDWYSDCSKLtHsLstsDItAIPEKENEGNDVPDC
O15151 S367 SIGNOR|iPTMNet|EPSD|PSP MDM4 MDMX tAIPEKENEGNDVPDCRRtIsAPVVRPKDAYIKKENSKLFD
O43255 S28 EPSD|PSP SIAH2 GPsANKPCsKQPPPQPQHtPsPAAPPAAATISAAGPGSSAV
O43255 S68 EPSD|PSP SIAH2 VPAAAAVISGPGGGGGAGPVsPQHHELTSLFECPVCFDYVL
O43255 T119 EPSD|PSP SIAH2 LVCNQCRQKLSCCPTCRGALtPSIRNLAMEKVASAVLFPCK
O43255 T26 EPSD|PSP SIAH2 stGPsANKPCsKQPPPQPQHtPsPAAPPAAATISAAGPGSS
O60664 Y251 PSP PLIN3 M6PRBP1 TIP47 QEQSyFVRLGsLSERLRQHAyEHsLGKLRATKQRAQEALLQ
O60673 S1075 EPSD|PSP REV3L POLZ REV3 AKKKTGKQQRTNNENIKRTLsFRKKRSHAILSPPSPSYNAE
O75369 S2497 Sugiyama FLNB FLN1L FLN3 TABP TAP VsPGsANEtssILVEsVTRsstETCysAIPKASSDASKVTS
O75385 S556 PSP ULK1 KIAA0722 PGssAPEHsPRTSGLGCRLHsAPNLSDLHVVRPKLPKPPTD
O75534 T761 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN
O94992 T270 Sugiyama HEXIM1 CLP1 EDG1 HIS1 MAQ1 GGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELIKE
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95197 S316 Sugiyama RTN3 ASYIP NSPL2 PLRNKEAGRYPMSALLSRQFsHtNAALEEVSRCVNDMHNFT
O95197 T318 Sugiyama RTN3 ASYIP NSPL2 RNKEAGRYPMSALLSRQFsHtNAALEEVSRCVNDMHNFTNE
O96017 S120 EPSD|PSP|Sugiyama CHEK2 CDS1 CHK2 RAD53 QDGFANLECVNDNYWFGRDKsCEyCFDEPLLKRTDKYRTYs
O96017 S140 EPSD|PSP CHEK2 CDS1 CHK2 RAD53 sCEyCFDEPLLKRTDKYRTYsKKHFRIFREVGPKNSyIAYI
O96017 S19 EPSD|PSP CHEK2 CDS1 CHK2 RAD53 __MSRESDVEAQQSHGSSACsQPHGSVtQsQGSSsQsQGIS
O96017 S260 EPSD|PSP CHEK2 CDS1 CHK2 RAD53 RKTCKKVAIKIISKRKFAIGsAREADPALNVETEIEILKKL
O96017 S33 EPSD|PSP CHEK2 CDS1 CHK2 RAD53 HGSSACsQPHGSVtQsQGSSsQsQGISSSSTSTMPNSsQSS
O96017 S35 EPSD|PSP CHEK2 CDS1 CHK2 RAD53 SSACsQPHGSVtQsQGSSsQsQGISSSSTSTMPNSsQSSHS
O96017 S379 GPS6|SIGNOR|EPSD|PSP CHEK2 CDS1 CHK2 RAD53 EEDCLIKITDFGHsKILGEtsLMRtLCGtPtyLAPEVLVSV
O96017 S435 EPSD|PSP CHEK2 CDS1 CHK2 RAD53 VILFICLSGYPPFSEHRtQVsLKDQITSGKYNFIPEVWAEV
O96017 S516 SIGNOR|ELM|EPSD|PSP CHEK2 CDS1 CHK2 RAD53 QDLLSEENESTALPQVLAQPstsRKRPREGEAEGAEttKRP
O96017 T225 EPSD|PSP CHEK2 CDS1 CHK2 RAD53 tVDDQsVYPKALRDEYIMSKtLGSGACGEVKLAFERKTCKK
O96017 T383 GPS6|SIGNOR|ELM|EPSD|PSP CHEK2 CDS1 CHK2 RAD53 LIKITDFGHsKILGEtsLMRtLCGtPtyLAPEVLVSVGTAG
O96017 T387 GPS6|SIGNOR|ELM|EPSD|PSP CHEK2 CDS1 CHK2 RAD53 TDFGHsKILGEtsLMRtLCGtPtyLAPEVLVSVGTAGYNRA
O96017 T432 EPSD|PSP CHEK2 CDS1 CHK2 RAD53 SLGVILFICLSGYPPFSEHRtQVsLKDQITSGKYNFIPEVW
O96017 T532 Sugiyama CHEK2 CDS1 CHK2 RAD53 LAQPstsRKRPREGEAEGAEttKRPAVCAAVL_________
O96017 T533 Sugiyama CHEK2 CDS1 CHK2 RAD53 AQPstsRKRPREGEAEGAEttKRPAVCAAVL__________
O96017 T68 SIGNOR|ELM|EPSD|PSP CHEK2 CDS1 CHK2 RAD53 NSsQSSHSSSGTLSsLETVStQELYsIPEDQEPEDQEPEEP
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00441 S60 SIGNOR SOD1 tEGLHGFHVHEFGDNtAGCtsAGPHFNPLSRKHGGPKDEER
P00441 S99 SIGNOR SOD1 ERHVGDLGNVtADKDGVADVsIEDsVIsLsGDHCIIGRTLV
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04637 S15 SIGNOR|EPSD|PSP TP53 P53 ______MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPL
P04637 S20 GPS6|SIGNOR|ELM|EPSD|PSP TP53 P53 _MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQAM
P04637 S366 SIGNOR|EPSD|PSP TP53 P53 EALELKDAQAGKEPGGSRAHssHLKsKKGQstsRHKKLMFK
P04637 S37 SIGNOR|EPSD|PSP TP53 P53 EtFsDLWKLLPENNVLsPLPsQAMDDLMLsPDDIEQWFtED
P04637 S378 SIGNOR|EPSD|PSP TP53 P53 EPGGSRAHssHLKsKKGQstsRHKKLMFKtEGPDsD_____
P04637 T18 SIGNOR|EPSD|PSP TP53 P53 ___MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQ
P04792 S78 Sugiyama HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05362 S43 Sugiyama ICAM1 GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P06400 S612 SIGNOR|EPSD|PSP RB1 LNLPLQNNHtAADMyLsPVRsPKKKGSTTRVNstANAETQA
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237 S427 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900 T467 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKEN
P07900 T65 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPNKQ
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 T60 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPNPQ
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0CG47 S57 Sugiyama UBB PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48 S57 Sugiyama UBC PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P10636 S579 SIGNOR MAPT MAPTL MTBT1 TAU RLQTAPVPMPDLKNVKsKIGstENLKHQPGGGKVQIINKKL
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11532 S3623 Sugiyama DMD EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P14618 S100 PSP PKM OIP3 PK2 PK3 PKM2 tHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGPEIR
P14618 T45 Sugiyama PKM OIP3 PK2 PK3 PKM2 TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P16070 S71 Sugiyama CD44 LHR MDU2 MDU3 MIC4 DLCKAFNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRI
P16403 S36 EPSD|PSP H1-2 H1F2 HIST1H1C EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P16403 S55 EPSD|PSP H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S89 EPSD|PSP H1-2 H1F2 HIST1H1C AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16403 T167 EPSD|PSP H1-2 H1F2 HIST1H1C PKKSAKKTPKKAKKPAAAtVtKKVAKsPKKAKVAKPKKAAK
P16403 T92 EPSD|PSP H1-2 H1F2 HIST1H1C DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18858 T183 Sugiyama LIG1 sLTEAEVAtEKEGEDGDQPttPPKPLKTSKAEtPtEsVsEP
P18887 S184 EPSD|PSP XRCC1 KVTVTKLGQFRVKEEDESANsLRPGALFFSRINKtsPVtAs
P18887 S210 EPSD|PSP XRCC1 LFFSRINKtsPVtAsDPAGPsyAAAtLQAsSAAssAsPVsR
P18887 T284 SIGNOR|EPSD|PSP XRCC1 QLsPsVPKRPKLPAPTRtPAtAPVPARAQGAVTGKPRGEGT
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P21127 S752 EPSD|PSP CDK11B CDC2L1 CDK11 PITSLREA PK58 PSMFPTWPAKSEQQRVKRGtsPRPPEGGLGysQLGDDDLKE
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23560 T62 EPSD|PSP BDNF TLESVNGPKAGSRGLTSLADtFEHVIEELLDEDQKVRPNEE
P25054 S1389 Sugiyama APC DP2.5 PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25054 S2129 Sugiyama APC DP2.5 NSIVSSLHQAAAAACLsRQAssDSDSILSLKsGIsLGsPFH
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P27348 T30 Sugiyama YWHAQ AKLAEQAERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKN
P29590 S117 GPS6|SIGNOR|EPSD|PSP PML MYL PP8675 RNF71 TRIM19 LGADTPALDNVFFESLQRRLsVYRQIVDAQAVCTRCKESAD
P29692 T147 Sugiyama EEF1D EF1D PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P30304 S124 SIGNOR|ELM|EPSD|PSP CDC25A RIHsLPQKLLGCsPALKRSHsDSLDHDIFQLIDPDENKENE
P30304 S178 SIGNOR|ELM|EPSD|PSP CDC25A GCLHSHGLQEGKDLFTQRQNsAPARMLsSNERDSSEPGNFI
P30304 S239 iPTMNet CDC25A VDLLDGENLKNEEETPSCMAsLWTAPLVMRTTNLDNRCKLF
P30304 S279 SIGNOR|ELM|EPSD|PSP CDC25A FDsPsLCssSTRSVLKRPERsQEEsPPGSTKRRKsMsGASP
P30304 S293 SIGNOR|ELM|EPSD|PSP CDC25A LKRPERsQEEsPPGSTKRRKsMsGASPKESTNPEKAHETLH
P30307 S216 SIGNOR|ELM|iPTMNet|EPSD|PSP CDC25C EFsLKDQEAKVSRsGLYRsPsMPENLNRPRLKQVEKFKDNt
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33527 S915 Sugiyama ABCC1 MRP MRP1 QMENGMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQ
P33981 T288 SIGNOR|EPSD|PSP TTK MPS1 MPS1L1 SCPFGRVPVNLLNsPDCDVKtDDsVVPCFMKRQTSRSECRD
P35221 S641 Sugiyama CTNNA1 GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P35579 S1916 Sugiyama MYH9 LQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMAR
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P38398 S988 SIGNOR|ELM|EPSD|PSP BRCA1 RNF53 PNKHGLLQNPYRIPPLFPIKsFVKTKCKKNLLEENFEEHsM
P40337 S111 SIGNOR|EPSD|PSP VHL FDGEPQPYPtLPPGtGRRIHsyRGHLWLFRDAGTHDGLLVN
P41091 T21 Sugiyama EIF2S3 EIF2G MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49588 S775 Sugiyama AARS1 AARS VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P51587 T3387 GPS6|EPSD BRCA2 FACD FANCD1 ESTRTAPTSSEDYLRLKRRCtTSLIKEQESSQASTEECEKN
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54132 T182 SIGNOR|EPSD|PSP BLM RECQ2 RECQL3 TSETSKsFVtPPQsHFVRVStAQKSKKGKRNFFKAQLYTTN
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61289 S247 SIGNOR|EPSD|PSP PSME3 QYVTLHDMILKNIEKIKRPRssNAETLY_____________
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62979 S57 Sugiyama RPS27A UBA80 UBCEP1 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987 S57 Sugiyama UBA52 UBCEP2 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
Q00587 S192 Sugiyama CDC42EP1 BORG5 CEP1 MSE55 PHDRDRDGsFPsEPGLRRsDsLLsFRLDLDLGPSLLSELLG
Q01094 S364 SIGNOR|ELM|iPTMNet|EPSD|PSP E2F1 RBBP3 tDPSQSLLSLEQEPLLSRMGsLRAPVDEDRLsPLVAADSLL
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q08050 S376 GPS6|SIGNOR|EPSD FOXM1 FKHL16 HFH11 MPP2 WIN KTELPLGARRKMKPLLPRVSsYLVPIQFPVNQSLVLQPSVK
Q12965 T939 Sugiyama MYO1E MYO1C SIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAPPPP
Q12965 Y941 Sugiyama MYO1E MYO1C GPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAPPPPGy
Q13049 S55 SIGNOR TRIM32 HT2A KLLHCGHTICRQCLEKLLASsINGVRCPFCSKITRITSLTQ
Q13263 S473 EPSD|PSP TRIM28 KAP1 RNF96 TIF1B sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13972 S287 SIGNOR RASGRF1 CDC25 GNRP GRF1 LRPLRMAASSKKPPITHDDVsSIFLNSETIMFLHQIFYQGL
Q14247 S282 Sugiyama CTTN EMS1 QKDyKTGFGGKFGVQsERQDsAAVGFDyKEKLAKHEsQQDy
Q14457 S90 SIGNOR|PSP BECN1 GT197 IETPRQDGVSRRFIPPARMMsTEsANsFTLIGEASDGGtME
Q14457 S93 SIGNOR|PSP BECN1 GT197 PRQDGVSRRFIPPARMMsTEsANsFTLIGEASDGGtMENLS
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q15056 T100 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 KFKGFCyVEFDEVDsLKEALtyDGALLGDRsLRVDIAEGRK
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15084 S389 Sugiyama PDIA6 ERP5 P5 TXNDC7 FALLKGsFsEQGINEFLRELsFGRGstAPVGGGAFPtIVER
Q15717 S100 EPSD|PSP ELAVL1 HUR TLNGLRLQsKTIKVSYARPssEVIKDANLyISGLPRTMtQK
Q15717 S88 EPSD|PSP ELAVL1 HUR yVTAKDAERAINTLNGLRLQsKTIKVSYARPssEVIKDANL
Q15717 T118 EPSD|PSP ELAVL1 HUR PssEVIKDANLyISGLPRTMtQKDVEDMFSRFGRIINSRVL
Q16626 S163 Sugiyama MEA1 MEA RTMAGVSLPAPGVPAWAREIsDAQWEDVVQKALQARQAsPA
Q2VIR3 T21 Sugiyama EIF2S3B MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF6 T36 Sugiyama HSP90AB4P LQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPNPR
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q58FF7 T60 Sugiyama HSP90AB3P HSP90BC LQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPNPQ
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 T60 Sugiyama HSP90AB2P HSP90BB LWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPNTQ
Q5JTD0 S545 Sugiyama TJAP1 PILT TJP4 ssRPQRsPKRMGVHHLHRKDsLtQAQEQGNLLN________
Q5SW79 S861 Sugiyama CEP170 FAM68A KAB KIAA0470 IEKPsPNIPIELIPHINKQTsstPssLALtsAsRIRERsEs
Q5TAX3 S831 Sugiyama TUT4 KIAA0191 ZCCHC11 KLDKKQDDLAPSETCLKKELsQCNCIDLsKsPDPDKSTGTD
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8WVC0 T477 Sugiyama LEO1 RDL FDVYKAPLQGDHNHLFIRQGtGLQGQAVFKTKLTFRPHstD
Q92945 S193 Sugiyama KHSRP FUBP2 DSGCKVQIsPDsGGLPERsVsLtGAPEsVQKAKMMLDDIVS
Q96G46 T273 Sugiyama DUS3L GAPRQENCGAQQVPAGPGtstPPssPVRtCGPLtDEDVVRL
Q96GD4 S331 PSP AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5 NPSERLPLAQVSAHPWVRANsRRVLPPSALQSVA_______
Q96MH2 T196 Sugiyama HEXIM2 L3 GDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELVRD
Q99541 Y232 PSP PLIN2 ADFP QKPSYYVRLGsLsTKLHSRAyQQALSRVKEAKQKSQQTISQ
Q99618 S94 Sugiyama CDCA3 C8 GRCC8 TOME1 ARtPMKTSsGDPPsPLVKQLsEVFETEDSKSNLPPEPVLPP
Q9BRS2 T509 Sugiyama RIOK1 RIO1 QVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHTTDPDI
Q9H6Z4 T124 Sugiyama RANBP3 GGEDsDREDGNyCPPVKRERtssLtQFPPSQSEERSSGFRL
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H788 S316 Sugiyama SH2D4A PPP1R38 SH2A NSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRAG
Q9H7D7 S123 Sugiyama WDR26 CDW2 MIP2 PRO0852 SSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLNQT
Q9NQS7 S91 PSP INCENP IsYVQDENRDPIRRRLSRRKsRSSQLSSRRLRSKDSVEKLA
Q9NRM7 S172 EPSD|PSP LATS2 KPM VIKQTSPGKGLMPTPVTRRPsFEGTGDSFASYHQLSGTPYE
Q9NRM7 S380 EPSD|PSP LATS2 KPM YELGSTSVQQWPAATLARRDsLQKPGLEAPPRAHVAFRPDC
Q9NRM7 S408 EPSD|PSP LATS2 KPM APPRAHVAFRPDCPVPSRTNsFNSHQPRPGPPGKAEPSLPA
Q9NRM7 S446 EPSD|PSP LATS2 KPM LPAPNTVTAVTAAHILHPVKsVRVLRPEPQTAVGPSHPAWV
Q9NW13 S122 PSP RBM28 PKAKKAKVADKKARLIIRNLsFKCSEDDLKTVFAQFGAVLE
Q9NY61 S141 iPTMNet AATF CHE1 DED HSPC277 DLGAAEEQECGDHRESKKSRsHsAKtPGFSVQsIsDFEKFT
Q9NY61 S143 SIGNOR|EPSD|PSP AATF CHE1 DED HSPC277 GAAEEQECGDHRESKKSRsHsAKtPGFSVQsIsDFEKFTKG
Q9NY61 S477 SIGNOR|EPSD|PSP AATF CHE1 DED HSPC277 IFDDDDFYHQLLRELIERKTsSLDPNDQVAMGRQWLAIQKL
Q9NY61 S510 SIGNOR|EPSD|PSP AATF CHE1 DED HSPC277 QWLAIQKLRSKIHKKVDRKAsKGRKLRFHVLSKLLSFMAPI
Q9UHR4 S331 EPSD|PSP BAIAP2L1 IRTKS SQRVNNsTGTSEDPSLQRsVsVATGLNMMKKQKVKTIFPHt
Q9UKV3 S388 Sugiyama ACIN1 ACINUS KIAA0670 EEEEREIKssQGLKEKsKsPsPPRLtEDRKKAsLVALPEQt
Q9ULD2 T1204 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 ENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRLs
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S1542 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDss
Q9Y266 T145 Sugiyama NUDC AENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKLKPNLGN
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 1.138848e-08 7.944 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.392813e-07 6.856 0 0
NRAGE signals death through JNK R-HSA-193648 2.346039e-07 6.630 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.583039e-06 5.801 0 0
RAB geranylgeranylation R-HSA-8873719 2.409446e-06 5.618 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.052811e-05 4.978 0 0
G alpha (12/13) signalling events R-HSA-416482 1.346002e-05 4.871 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.036957e-05 4.691 0 0
Axon guidance R-HSA-422475 2.386682e-05 4.622 0 0
FOXO-mediated transcription R-HSA-9614085 3.317426e-05 4.479 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.644135e-05 4.333 0 0
Death Receptor Signaling R-HSA-73887 5.309466e-05 4.275 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.751085e-05 4.171 0 0
DARPP-32 events R-HSA-180024 9.571582e-05 4.019 0 0
Cell Cycle R-HSA-1640170 1.339604e-04 3.873 1 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.272081e-04 3.895 0 0
Nervous system development R-HSA-9675108 1.369288e-04 3.864 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.470424e-04 3.833 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.204782e-04 3.494 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.990252e-04 3.399 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.990252e-04 3.399 0 0
Neuronal System R-HSA-112316 3.818955e-04 3.418 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.274785e-04 3.369 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.281429e-04 3.138 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.004438e-04 3.097 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.077746e-04 3.093 0 0
Rab regulation of trafficking R-HSA-9007101 8.268438e-04 3.083 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.530755e-04 3.069 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.022793e-04 3.045 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.127541e-03 2.948 0 0
Opioid Signalling R-HSA-111885 1.240489e-03 2.906 0 0
Cell Cycle, Mitotic R-HSA-69278 1.563462e-03 2.806 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.759873e-03 2.755 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.696882e-03 2.770 0 0
Calmodulin induced events R-HSA-111933 1.854306e-03 2.732 0 0
CaM pathway R-HSA-111997 1.854306e-03 2.732 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.844304e-03 2.734 0 0
DAG and IP3 signaling R-HSA-1489509 2.249613e-03 2.648 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.504272e-03 2.601 0 0
Regulation of TP53 Activity R-HSA-5633007 2.500826e-03 2.602 1 0
Apoptotic execution phase R-HSA-75153 2.567403e-03 2.591 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.729810e-03 2.564 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.788222e-03 2.555 1 0
Diseases of mitotic cell cycle R-HSA-9675126 3.141719e-03 2.503 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.141719e-03 2.503 0 0
Developmental Biology R-HSA-1266738 3.162835e-03 2.500 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.162643e-03 2.500 0 0
Neurodegenerative Diseases R-HSA-8863678 3.216928e-03 2.493 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.216928e-03 2.493 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.310562e-03 2.480 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.669242e-03 2.435 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.665489e-03 2.436 0 0
Cell Cycle Checkpoints R-HSA-69620 3.529774e-03 2.452 1 0
Post NMDA receptor activation events R-HSA-438064 3.599186e-03 2.444 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.676046e-03 2.435 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.055836e-03 2.392 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.050159e-03 2.393 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.939995e-03 2.405 0 0
Signaling by VEGF R-HSA-194138 3.962238e-03 2.402 0 0
FLT3 Signaling R-HSA-9607240 3.804418e-03 2.420 0 0
Transmission across Chemical Synapses R-HSA-112315 4.121197e-03 2.385 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.217762e-03 2.375 0 0
Signaling by ALK in cancer R-HSA-9700206 4.217762e-03 2.375 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.473083e-03 2.349 0 0
Rap1 signalling R-HSA-392517 4.473083e-03 2.349 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.732001e-03 2.325 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.732001e-03 2.325 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.732001e-03 2.325 0 0
RNA Polymerase II Transcription R-HSA-73857 4.876457e-03 2.312 1 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.920087e-03 2.308 0 0
Ca-dependent events R-HSA-111996 4.929957e-03 2.307 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.096596e-03 2.293 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.350402e-03 2.272 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.451931e-03 2.263 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.689480e-03 2.245 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 6.683769e-03 2.175 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.103267e-03 2.214 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.519455e-03 2.186 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 6.683769e-03 2.175 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 6.683769e-03 2.175 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 6.683769e-03 2.175 0 0
RET signaling R-HSA-8853659 6.463310e-03 2.190 0 0
Generic Transcription Pathway R-HSA-212436 6.779871e-03 2.169 1 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.327799e-03 2.135 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.764577e-03 2.110 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 7.764577e-03 2.110 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 7.782784e-03 2.109 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.401243e-03 2.076 0 0
Signaling by ROBO receptors R-HSA-376176 8.251608e-03 2.083 0 0
Cellular Senescence R-HSA-2559583 8.753461e-03 2.058 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.997209e-03 2.046 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.172337e-03 2.038 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.013757e-02 1.994 0 0
Co-stimulation by CD28 R-HSA-389356 9.891828e-03 2.005 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 9.614525e-03 2.017 0 0
Gene expression (Transcription) R-HSA-74160 1.010590e-02 1.995 1 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.075349e-02 1.968 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.104435e-02 1.957 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.251848e-02 1.902 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.257083e-02 1.901 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.367862e-02 1.864 0 0
Cardiac conduction R-HSA-5576891 1.321108e-02 1.879 0 0
PLC beta mediated events R-HSA-112043 1.315984e-02 1.881 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.445604e-02 1.840 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.447740e-02 1.839 0 0
PKA activation in glucagon signalling R-HSA-164378 1.586297e-02 1.800 0 0
mRNA 3'-end processing R-HSA-72187 1.484834e-02 1.828 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.484834e-02 1.828 0 0
PKA activation R-HSA-163615 1.586297e-02 1.800 0 0
Polo-like kinase mediated events R-HSA-156711 1.586297e-02 1.800 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.546976e-02 1.811 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.586297e-02 1.800 0 0
Semaphorin interactions R-HSA-373755 1.571631e-02 1.804 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.565108e-02 1.805 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.603356e-02 1.795 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.611962e-02 1.793 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.633136e-02 1.787 0 0
Meiotic synapsis R-HSA-1221632 1.633136e-02 1.787 0 0
TBC/RABGAPs R-HSA-8854214 1.654188e-02 1.781 0 0
Mitotic Prometaphase R-HSA-68877 1.680882e-02 1.774 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.805502e-02 1.743 0 0
Netrin-1 signaling R-HSA-373752 1.832632e-02 1.737 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.862434e-02 1.730 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.901511e-02 1.721 0 0
Potassium Channels R-HSA-1296071 1.963412e-02 1.707 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.966593e-02 1.706 0 0
Formation of definitive endoderm R-HSA-9823730 2.178144e-02 1.662 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.142980e-02 1.669 0 0
Ion homeostasis R-HSA-5578775 2.142980e-02 1.669 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.178144e-02 1.662 0 0
G-protein mediated events R-HSA-112040 2.190935e-02 1.659 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.253175e-02 1.647 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.319953e-02 1.635 0 0
Muscle contraction R-HSA-397014 2.342175e-02 1.630 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.660491e-02 1.575 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.660491e-02 1.575 0 0
Potassium transport channels R-HSA-1296067 2.660491e-02 1.575 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.660491e-02 1.575 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.660491e-02 1.575 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.660491e-02 1.575 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.660491e-02 1.575 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.660491e-02 1.575 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.660491e-02 1.575 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.660491e-02 1.575 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.660491e-02 1.575 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.660491e-02 1.575 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.652492e-02 1.576 0 0
Glycolysis R-HSA-70171 2.539371e-02 1.595 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.443750e-02 1.612 0 0
MAPK family signaling cascades R-HSA-5683057 2.738362e-02 1.563 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.772195e-02 1.557 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.772195e-02 1.557 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.897446e-02 1.538 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.897446e-02 1.538 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.279343e-02 1.484 0 0
Type I hemidesmosome assembly R-HSA-446107 3.279343e-02 1.484 0 0
Trafficking of AMPA receptors R-HSA-399719 3.080586e-02 1.511 0 0
HIV Transcription Elongation R-HSA-167169 3.059820e-02 1.514 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.059820e-02 1.514 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.059820e-02 1.514 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.231500e-02 1.491 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.192906e-02 1.496 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.279343e-02 1.484 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.279343e-02 1.484 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.279343e-02 1.484 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.061987e-02 1.514 0 0
EPH-Ephrin signaling R-HSA-2682334 2.998243e-02 1.523 0 0
DCC mediated attractive signaling R-HSA-418885 3.286145e-02 1.483 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.366838e-02 1.473 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.488091e-02 1.457 0 0
M Phase R-HSA-68886 3.612888e-02 1.442 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.654101e-02 1.437 0 0
Signaling by ERBB4 R-HSA-1236394 3.671804e-02 1.435 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.693684e-02 1.433 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 3.991213e-02 1.399 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.069753e-02 1.390 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.069753e-02 1.390 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.069753e-02 1.390 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.069753e-02 1.390 0 0
Separation of Sister Chromatids R-HSA-2467813 4.194740e-02 1.377 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.223921e-02 1.374 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.817062e-02 1.418 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.069753e-02 1.390 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.021651e-02 1.396 1 1
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.817062e-02 1.418 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.040752e-02 1.394 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.042558e-02 1.393 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 4.058379e-02 1.392 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.446966e-02 1.352 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 4.458077e-02 1.351 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 4.458077e-02 1.351 0 0
Mitotic Anaphase R-HSA-68882 4.577896e-02 1.339 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.590586e-02 1.338 0 0
RAF activation R-HSA-5673000 4.657044e-02 1.332 0 0
Long-term potentiation R-HSA-9620244 4.744003e-02 1.324 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.749097e-02 1.323 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.796901e-02 1.319 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.946984e-02 1.306 0 0
Programmed Cell Death R-HSA-5357801 4.954645e-02 1.305 0 0
HCN channels R-HSA-1296061 5.519349e-02 1.258 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.519349e-02 1.258 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.519349e-02 1.258 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.834447e-02 1.234 0 0
Transcription of the HIV genome R-HSA-167172 5.323504e-02 1.274 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.403891e-02 1.267 0 0
Dopamine receptors R-HSA-390651 5.519349e-02 1.258 0 0
Ephrin signaling R-HSA-3928664 5.834447e-02 1.234 0 0
TRP channels R-HSA-3295583 5.293370e-02 1.276 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.521803e-02 1.258 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.834447e-02 1.234 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.834447e-02 1.234 0 0
Signaling by Hippo R-HSA-2028269 5.120853e-02 1.291 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.206540e-02 1.283 0 0
Sensory processing of sound R-HSA-9659379 5.081021e-02 1.294 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.206540e-02 1.283 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.400768e-02 1.268 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.293370e-02 1.276 0 0
Specification of primordial germ cells R-HSA-9827857 5.120853e-02 1.291 0 0
PI Metabolism R-HSA-1483255 5.641764e-02 1.249 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.878184e-02 1.231 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.878184e-02 1.231 0 0
Signaling by APC mutants R-HSA-4839744 5.908158e-02 1.229 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.908158e-02 1.229 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.908158e-02 1.229 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.908158e-02 1.229 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 6.073824e-02 1.217 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 6.073824e-02 1.217 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 7.216058e-02 1.142 0 0
IRS activation R-HSA-74713 7.216058e-02 1.142 0 0
G2 Phase R-HSA-68911 7.216058e-02 1.142 0 0
Activation of RAC1 R-HSA-428540 6.949785e-02 1.158 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.949785e-02 1.158 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.949785e-02 1.158 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.598210e-02 1.181 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.598210e-02 1.181 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.498377e-02 1.187 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.498377e-02 1.187 0 0
HIV elongation arrest and recovery R-HSA-167287 6.498377e-02 1.187 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.498377e-02 1.187 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 7.224040e-02 1.141 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.079432e-02 1.216 0 0
Specification of the neural plate border R-HSA-9834899 6.598210e-02 1.181 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.053177e-02 1.218 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.598210e-02 1.181 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 7.216058e-02 1.142 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 7.216058e-02 1.142 0 0
Kinesins R-HSA-983189 6.778627e-02 1.169 0 0
The NLRP3 inflammasome R-HSA-844456 6.598210e-02 1.181 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 7.216058e-02 1.142 0 0
Signaling by AXIN mutants R-HSA-4839735 6.949785e-02 1.158 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.949785e-02 1.158 0 0
Apoptosis R-HSA-109581 6.570416e-02 1.182 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.843867e-02 1.165 0 0
NGF-stimulated transcription R-HSA-9031628 6.564069e-02 1.183 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.739181e-02 1.171 0 0
NrCAM interactions R-HSA-447038 7.216058e-02 1.142 0 0
Regulation of beta-cell development R-HSA-186712 6.341728e-02 1.198 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.262329e-02 1.139 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.262329e-02 1.139 0 0
Glucose metabolism R-HSA-70326 7.352740e-02 1.134 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.411236e-02 1.130 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.411236e-02 1.130 0 0
Attenuation phase R-HSA-3371568 7.818112e-02 1.107 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.819794e-02 1.107 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.819794e-02 1.107 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.843958e-02 1.105 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.843958e-02 1.105 0 0
Interleukin-37 signaling R-HSA-9008059 7.843958e-02 1.105 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.067886e-02 1.093 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.067886e-02 1.093 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.067886e-02 1.093 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.067886e-02 1.093 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.067886e-02 1.093 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.067886e-02 1.093 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.067886e-02 1.093 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.067886e-02 1.093 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.067886e-02 1.093 0 0
Disorders of Nervous System Development R-HSA-9697154 8.067886e-02 1.093 0 0
Pervasive developmental disorders R-HSA-9005895 8.067886e-02 1.093 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.197830e-02 1.086 1 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 8.197830e-02 1.086 0 0
Signaling by PTK6 R-HSA-8848021 8.197830e-02 1.086 0 0
Mitotic Prophase R-HSA-68875 8.391584e-02 1.076 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 8.438854e-02 1.074 0 0
EGFR downregulation R-HSA-182971 8.568562e-02 1.067 0 0
Regulation of insulin secretion R-HSA-422356 8.617563e-02 1.065 0 0
Neurexins and neuroligins R-HSA-6794361 8.677030e-02 1.062 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.750145e-02 1.058 0 0
Developmental Cell Lineages R-HSA-9734767 8.793777e-02 1.056 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 9.055269e-02 1.043 0 0
Signaling by MAPK mutants R-HSA-9652817 9.055269e-02 1.043 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 9.055269e-02 1.043 0 0
CREB phosphorylation R-HSA-199920 1.101345e-01 0.958 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.101345e-01 0.958 0 0
Formation of axial mesoderm R-HSA-9796292 9.258105e-02 1.033 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 9.258105e-02 1.033 0 0
Formation of lateral plate mesoderm R-HSA-9758920 9.055269e-02 1.043 0 0
Signaling by WNT in cancer R-HSA-4791275 9.326986e-02 1.030 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.011855e-01 0.995 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.094248e-01 0.961 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.094248e-01 0.961 0 0
Integration of energy metabolism R-HSA-163685 1.062709e-01 0.974 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 9.055269e-02 1.043 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 9.055269e-02 1.043 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 9.055269e-02 1.043 0 0
Gastrulation R-HSA-9758941 1.087396e-01 0.964 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.092328e-01 0.962 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.013342e-01 0.994 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 9.258105e-02 1.033 0 0
Maturation of nucleoprotein R-HSA-9683610 9.258105e-02 1.033 0 0
Signaling by Interleukins R-HSA-449147 1.014806e-01 0.994 0 0
HDL assembly R-HSA-8963896 1.051580e-01 0.978 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.177908e-01 0.929 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.177908e-01 0.929 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.177908e-01 0.929 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.177908e-01 0.929 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.177908e-01 0.929 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 1.177908e-01 0.929 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.177908e-01 0.929 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.177908e-01 0.929 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.177908e-01 0.929 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.713811e-01 0.766 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 1.713811e-01 0.766 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.713811e-01 0.766 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.713811e-01 0.766 0 0
Intestinal infectious diseases R-HSA-8942233 1.713811e-01 0.766 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 1.713811e-01 0.766 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.713811e-01 0.766 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.713811e-01 0.766 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.713811e-01 0.766 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.713811e-01 0.766 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 1.713811e-01 0.766 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 1.713811e-01 0.766 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.713811e-01 0.766 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 1.713811e-01 0.766 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 2.217190e-01 0.654 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 2.217190e-01 0.654 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 2.217190e-01 0.654 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 2.217190e-01 0.654 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.306939e-01 0.884 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 1.306939e-01 0.884 0 0
SOS-mediated signalling R-HSA-112412 1.306939e-01 0.884 0 0
Disinhibition of SNARE formation R-HSA-114516 1.306939e-01 0.884 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.306939e-01 0.884 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 2.690018e-01 0.570 0 0
MET activates PTPN11 R-HSA-8865999 2.690018e-01 0.570 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 2.690018e-01 0.570 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 2.690018e-01 0.570 0 0
Invadopodia formation R-HSA-8941237 2.690018e-01 0.570 0 0
Activation of RAS in B cells R-HSA-1169092 1.520403e-01 0.818 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.740025e-01 0.759 0 0
TNFR1-mediated ceramide production R-HSA-5626978 3.134147e-01 0.504 0 0
ATP sensitive Potassium channels R-HSA-1296025 3.134147e-01 0.504 0 0
Defective MAT1A causes MATD R-HSA-5579024 3.134147e-01 0.504 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.134147e-01 0.504 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 3.134147e-01 0.504 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 3.134147e-01 0.504 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.183613e-01 0.927 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.964270e-01 0.707 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.964270e-01 0.707 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.964270e-01 0.707 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.321412e-01 0.879 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.464474e-01 0.834 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 2.191769e-01 0.659 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.551318e-01 0.450 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 3.551318e-01 0.450 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 3.551318e-01 0.450 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.551318e-01 0.450 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.551318e-01 0.450 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.551318e-01 0.450 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.612292e-01 0.793 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.421302e-01 0.616 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.421302e-01 0.616 0 0
ERKs are inactivated R-HSA-202670 2.421302e-01 0.616 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.421302e-01 0.616 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 1.764363e-01 0.753 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.943164e-01 0.404 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.943164e-01 0.404 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.943164e-01 0.404 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.943164e-01 0.404 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.943164e-01 0.404 0 0
PDE3B signalling R-HSA-165160 3.943164e-01 0.404 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.943164e-01 0.404 0 0
PKB-mediated events R-HSA-109703 3.943164e-01 0.404 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.943164e-01 0.404 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 3.943164e-01 0.404 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.943164e-01 0.404 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.551261e-01 0.809 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.551261e-01 0.809 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.241200e-01 0.650 0 0
Signaling by Erythropoietin R-HSA-9006335 1.791141e-01 0.747 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.791141e-01 0.747 0 0
mRNA Capping R-HSA-72086 1.791141e-01 0.747 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.791141e-01 0.747 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.454297e-01 0.837 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.270518e-01 0.896 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.270518e-01 0.896 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.270518e-01 0.896 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.915471e-01 0.718 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.915471e-01 0.718 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.405446e-01 0.619 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.111856e-01 0.507 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.311223e-01 0.365 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.311223e-01 0.365 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.311223e-01 0.365 0 0
STAT5 Activation R-HSA-9645135 4.311223e-01 0.365 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 4.311223e-01 0.365 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.311223e-01 0.365 0 0
FGFR2 alternative splicing R-HSA-6803529 2.571593e-01 0.590 0 0
Notch-HLH transcription pathway R-HSA-350054 2.571593e-01 0.590 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 1.753234e-01 0.756 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.339856e-01 0.476 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.339856e-01 0.476 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.739219e-01 0.562 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.739219e-01 0.562 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.964403e-01 0.707 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 1.964403e-01 0.707 0 0
HIV Transcription Initiation R-HSA-167161 1.964403e-01 0.707 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 1.964403e-01 0.707 0 0
HSF1-dependent transactivation R-HSA-3371571 1.691257e-01 0.772 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.907920e-01 0.536 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.907920e-01 0.536 0 0
Phosphorylation of the APC/C R-HSA-176412 3.565599e-01 0.448 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.408410e-01 0.851 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 2.183798e-01 0.661 0 0
Centrosome maturation R-HSA-380287 1.546341e-01 0.811 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.788518e-01 0.422 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.788518e-01 0.422 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 2.410280e-01 0.618 0 0
G1/S-Specific Transcription R-HSA-69205 2.845707e-01 0.546 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.008123e-01 0.397 0 0
Metabolism of non-coding RNA R-HSA-194441 2.462835e-01 0.609 0 0
snRNP Assembly R-HSA-191859 2.462835e-01 0.609 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.878750e-01 0.726 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.586105e-01 0.445 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.263858e-01 0.486 0 0
GAB1 signalosome R-HSA-180292 4.223995e-01 0.374 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.404251e-01 0.468 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.404251e-01 0.468 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.250003e-01 0.648 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.881414e-01 0.540 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.881414e-01 0.540 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.251441e-01 0.648 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 1.864779e-01 0.729 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.364090e-01 0.473 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.685372e-01 0.434 0 0
Cellular response to heat stress R-HSA-3371556 2.314140e-01 0.636 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.204498e-01 0.494 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.840957e-01 0.547 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.546746e-01 0.594 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.546746e-01 0.594 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.810324e-01 0.551 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.418070e-01 0.355 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.381937e-01 0.358 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.062508e-01 0.391 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.601902e-01 0.443 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.290492e-01 0.483 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.364591e-01 0.360 0 0
mRNA Splicing R-HSA-72172 4.333661e-01 0.363 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.247032e-01 0.489 0 0
Signaling by EGFR R-HSA-177929 1.113226e-01 0.953 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.241200e-01 0.650 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.241200e-01 0.650 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.612292e-01 0.793 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.612292e-01 0.793 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.882249e-01 0.540 0 0
MET promotes cell motility R-HSA-8875878 3.123834e-01 0.505 0 0
G1/S Transition R-HSA-69206 1.745774e-01 0.758 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.079297e-01 0.682 0 0
Neutrophil degranulation R-HSA-6798695 3.767974e-01 0.424 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.667561e-01 0.574 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.667561e-01 0.574 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.247032e-01 0.489 0 0
Signaling by ERBB2 R-HSA-1227986 1.391471e-01 0.857 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.551261e-01 0.809 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.964403e-01 0.707 0 0
Signaling by FGFR2 R-HSA-5654738 3.159554e-01 0.500 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.764363e-01 0.753 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.964270e-01 0.707 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.421302e-01 0.616 0 0
MAP2K and MAPK activation R-HSA-5674135 1.964403e-01 0.707 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.980597e-01 0.703 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.667561e-01 0.574 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.980597e-01 0.703 0 0
Signaling by FGFR4 R-HSA-5654743 3.965731e-01 0.402 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.520403e-01 0.818 0 0
PI3K/AKT activation R-HSA-198203 1.964270e-01 0.707 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.418070e-01 0.355 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.243984e-01 0.372 0 0
Peptide chain elongation R-HSA-156902 4.062508e-01 0.391 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.764363e-01 0.753 0 0
Signaling by RAS mutants R-HSA-6802949 1.270518e-01 0.896 0 0
Signaling by FGFR3 R-HSA-5654741 4.243984e-01 0.372 0 0
Adrenoceptors R-HSA-390696 1.520403e-01 0.818 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 1.520403e-01 0.818 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.113005e-01 0.954 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.651782e-01 0.576 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 2.651782e-01 0.576 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.943164e-01 0.404 0 0
Telomere C-strand synthesis initiation R-HSA-174430 3.339856e-01 0.476 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.465868e-01 0.834 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.788518e-01 0.422 0 0
GABA receptor activation R-HSA-977443 2.565873e-01 0.591 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.383659e-01 0.859 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.075430e-01 0.683 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.436174e-01 0.843 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.413636e-01 0.355 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.413636e-01 0.355 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.651782e-01 0.576 0 0
Inwardly rectifying K+ channels R-HSA-1296065 2.171728e-01 0.663 0 0
Generation of second messenger molecules R-HSA-202433 3.404251e-01 0.468 0 0
Adipogenesis R-HSA-9843745 3.188517e-01 0.496 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.553868e-01 0.809 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.306939e-01 0.884 0 0
Formation of the posterior neural plate R-HSA-9832991 2.191769e-01 0.659 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.421302e-01 0.616 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.920194e-01 0.717 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.241200e-01 0.650 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.193181e-01 0.923 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.339856e-01 0.476 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.964403e-01 0.707 0 0
IRS-mediated signalling R-HSA-112399 2.260570e-01 0.646 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.238345e-01 0.650 0 0
Aggrephagy R-HSA-9646399 3.404251e-01 0.468 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.251441e-01 0.648 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.964403e-01 0.707 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.055662e-01 0.515 0 0
Triglyceride catabolism R-HSA-163560 1.359921e-01 0.866 0 0
Cyclin D associated events in G1 R-HSA-69231 1.118267e-01 0.951 0 0
G1 Phase R-HSA-69236 1.118267e-01 0.951 0 0
Signaling by FGFR2 in disease R-HSA-5655253 2.999921e-01 0.523 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.341847e-01 0.872 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.977255e-01 0.526 0 0
TNF signaling R-HSA-75893 3.731565e-01 0.428 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.111856e-01 0.507 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 3.339856e-01 0.476 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.008123e-01 0.397 0 0
Nuclear RNA decay R-HSA-9930044 4.418070e-01 0.355 0 0
Cardiogenesis R-HSA-9733709 2.303182e-01 0.638 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.459915e-01 0.836 0 0
Signaling by FGFR in disease R-HSA-1226099 1.476587e-01 0.831 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 4.311223e-01 0.365 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.586105e-01 0.445 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.754836e-01 0.425 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.381937e-01 0.358 0 0
mRNA Editing R-HSA-75072 1.740025e-01 0.759 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.665421e-01 0.574 0 0
Apoptotic factor-mediated response R-HSA-111471 4.223995e-01 0.374 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.418070e-01 0.355 0 0
Hedgehog 'off' state R-HSA-5610787 1.642777e-01 0.784 0 0
IGF1R signaling cascade R-HSA-2428924 1.699906e-01 0.770 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.303182e-01 0.638 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.348406e-01 0.870 0 0
GPCR downstream signalling R-HSA-388396 1.651686e-01 0.782 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.177908e-01 0.929 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 1.713811e-01 0.766 0 0
mRNA Editing: A to I Conversion R-HSA-75064 2.217190e-01 0.654 0 0
Regulation of cortical dendrite branching R-HSA-8985801 2.217190e-01 0.654 0 0
C6 deamination of adenosine R-HSA-75102 2.217190e-01 0.654 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 2.217190e-01 0.654 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.217190e-01 0.654 0 0
Regulation of PTEN localization R-HSA-8948747 1.306939e-01 0.884 0 0
MET interacts with TNS proteins R-HSA-8875513 2.690018e-01 0.570 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.520403e-01 0.818 0 0
Co-stimulation by ICOS R-HSA-9927354 1.520403e-01 0.818 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.740025e-01 0.759 0 0
Alanine metabolism R-HSA-8964540 3.134147e-01 0.504 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.134147e-01 0.504 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.191769e-01 0.659 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.551318e-01 0.450 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.421302e-01 0.616 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 1.436174e-01 0.843 0 0
Metalloprotease DUBs R-HSA-5689901 1.436174e-01 0.843 0 0
Formation of the Editosome R-HSA-75094 3.943164e-01 0.404 0 0
Phosphorylation of Emi1 R-HSA-176417 3.943164e-01 0.404 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.179788e-01 0.928 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.882249e-01 0.540 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 2.241200e-01 0.650 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.339856e-01 0.476 0 0
PI3K Cascade R-HSA-109704 1.602812e-01 0.795 0 0
Phase 4 - resting membrane potential R-HSA-5576886 3.565599e-01 0.448 0 0
Meiosis R-HSA-1500620 1.348406e-01 0.870 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.077312e-01 0.512 0 0
Triglyceride metabolism R-HSA-8979227 2.462835e-01 0.609 0 0
GPER1 signaling R-HSA-9634597 2.760766e-01 0.559 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.098227e-01 0.678 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.404251e-01 0.468 0 0
Diseases of Immune System R-HSA-5260271 3.404251e-01 0.468 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.251441e-01 0.648 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.254497e-01 0.371 0 0
G alpha (s) signalling events R-HSA-418555 3.078173e-01 0.512 0 0
Selective autophagy R-HSA-9663891 2.664288e-01 0.574 0 0
Insulin receptor signalling cascade R-HSA-74751 2.988403e-01 0.525 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.781352e-01 0.749 0 0
p75NTR signals via NF-kB R-HSA-193639 3.339856e-01 0.476 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.907920e-01 0.536 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.339856e-01 0.476 0 0
S Phase R-HSA-69242 1.654297e-01 0.781 0 0
Signaling by TGFB family members R-HSA-9006936 2.321205e-01 0.634 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.347570e-01 0.362 0 0
Signaling by Hedgehog R-HSA-5358351 2.703151e-01 0.568 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.251861e-01 0.488 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.179788e-01 0.928 0 0
FGFR2 mutant receptor activation R-HSA-1839126 2.845707e-01 0.546 0 0
FLT3 signaling in disease R-HSA-9682385 1.359921e-01 0.866 0 0
Heme signaling R-HSA-9707616 1.542108e-01 0.812 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.324003e-01 0.634 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.251861e-01 0.488 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.495736e-01 0.456 0 0
HIV Life Cycle R-HSA-162587 4.165728e-01 0.380 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.708028e-01 0.567 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 2.525818e-01 0.598 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 2.525818e-01 0.598 0 0
Membrane Trafficking R-HSA-199991 1.175448e-01 0.930 0 0
Signal attenuation R-HSA-74749 1.964270e-01 0.707 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 1.464474e-01 0.834 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.495736e-01 0.456 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.422765e-01 0.466 0 0
Parasitic Infection Pathways R-HSA-9824443 2.620857e-01 0.582 0 0
Leishmania infection R-HSA-9658195 2.620857e-01 0.582 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.964270e-01 0.707 0 0
Integrin signaling R-HSA-354192 2.303182e-01 0.638 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.485035e-01 0.605 0 0
HIV Infection R-HSA-162906 3.818763e-01 0.418 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.436174e-01 0.843 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.039505e-01 0.394 0 0
Signaling by NOTCH1 R-HSA-1980143 4.302676e-01 0.366 0 0
G2/M Transition R-HSA-69275 1.521712e-01 0.818 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.485035e-01 0.605 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.485035e-01 0.605 0 0
Cellular response to chemical stress R-HSA-9711123 3.523815e-01 0.453 0 0
Interleukin-1 family signaling R-HSA-446652 3.790523e-01 0.421 0 0
Interleukin-1 processing R-HSA-448706 1.740025e-01 0.759 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 3.134147e-01 0.504 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 3.943164e-01 0.404 0 0
HATs acetylate histones R-HSA-3214847 3.852179e-01 0.414 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.521013e-01 0.818 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.275487e-01 0.369 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.275487e-01 0.369 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.775263e-01 0.557 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.622560e-01 0.581 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.854184e-01 0.545 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.161541e-01 0.665 0 0
TGFBR3 expression R-HSA-9839394 1.324625e-01 0.878 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.651782e-01 0.576 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.882249e-01 0.540 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.791141e-01 0.747 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.565599e-01 0.448 0 0
Regulation of BACH1 activity R-HSA-9708530 3.565599e-01 0.448 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.077312e-01 0.512 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.161541e-01 0.665 0 0
Ub-specific processing proteases R-HSA-5689880 4.275487e-01 0.369 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.243984e-01 0.372 0 0
Cellular responses to stress R-HSA-2262752 2.822714e-01 0.549 0 0
Activation of BH3-only proteins R-HSA-114452 1.915471e-01 0.718 0 0
Formation of the nephric duct R-HSA-9830364 3.077312e-01 0.512 0 0
Cell junction organization R-HSA-446728 2.476619e-01 0.606 0 0
Aquaporin-mediated transport R-HSA-445717 1.465868e-01 0.834 0 0
Inflammasomes R-HSA-622312 1.669660e-01 0.777 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 1.964403e-01 0.707 0 0
Cellular responses to stimuli R-HSA-8953897 1.527337e-01 0.816 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.342303e-01 0.362 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.922760e-01 0.716 0 0
Chromatin modifying enzymes R-HSA-3247509 1.253734e-01 0.902 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.213685e-01 0.916 0 0
Cell-Cell communication R-HSA-1500931 2.193145e-01 0.659 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.713811e-01 0.766 0 0
DSCAM interactions R-HSA-376172 2.217190e-01 0.654 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.690018e-01 0.570 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.690018e-01 0.570 0 0
NADE modulates death signalling R-HSA-205025 3.134147e-01 0.504 0 0
Tandem pore domain potassium channels R-HSA-1296346 1.964270e-01 0.707 0 0
Disorders of Developmental Biology R-HSA-9675151 1.464474e-01 0.834 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.421302e-01 0.616 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.943164e-01 0.404 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.943164e-01 0.404 0 0
Abacavir transmembrane transport R-HSA-2161517 4.311223e-01 0.365 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 2.907920e-01 0.536 0 0
Negative regulation of FLT3 R-HSA-9706369 3.565599e-01 0.448 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.223995e-01 0.374 1 1
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.251441e-01 0.648 0 0
Amine ligand-binding receptors R-HSA-375280 4.105200e-01 0.387 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.879889e-01 0.541 1 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.879889e-01 0.541 1 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.089282e-01 0.388 0 0
Protein hydroxylation R-HSA-9629569 2.079297e-01 0.682 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.339856e-01 0.476 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.008123e-01 0.397 0 0
Deubiquitination R-HSA-5688426 3.655892e-01 0.437 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.276929e-01 0.894 0 0
G0 and Early G1 R-HSA-1538133 2.171728e-01 0.663 0 0
Pyroptosis R-HSA-5620971 3.586105e-01 0.445 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.571593e-01 0.590 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.339856e-01 0.476 0 0
Chromatin organization R-HSA-4839726 1.828519e-01 0.738 0 0
Signaling by GPCR R-HSA-372790 3.089033e-01 0.510 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.339856e-01 0.476 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.788518e-01 0.422 0 0
Reproduction R-HSA-1474165 1.342852e-01 0.872 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.366034e-01 0.865 0 0
Formation of the anterior neural plate R-HSA-9823739 1.183613e-01 0.927 0 0
Signaling by TGFBR3 R-HSA-9839373 1.270518e-01 0.896 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.217190e-01 0.654 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.306939e-01 0.884 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.690018e-01 0.570 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.134147e-01 0.504 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.551318e-01 0.450 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.943164e-01 0.404 0 0
Regulation of KIT signaling R-HSA-1433559 3.111856e-01 0.507 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 4.311223e-01 0.365 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.565599e-01 0.448 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.770561e-01 0.752 0 0
Signaling by NTRKs R-HSA-166520 1.654297e-01 0.781 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 3.922649e-01 0.406 0 0
MAP kinase activation R-HSA-450294 4.342303e-01 0.362 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.193011e-01 0.377 0 0
Regulated Necrosis R-HSA-5218859 3.422765e-01 0.466 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.418070e-01 0.355 0 0
Other interleukin signaling R-HSA-449836 1.920194e-01 0.717 0 0
Signaling by SCF-KIT R-HSA-1433557 2.183798e-01 0.661 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.303182e-01 0.638 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.915471e-01 0.718 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.651782e-01 0.576 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.241200e-01 0.650 0 0
L1CAM interactions R-HSA-373760 1.218460e-01 0.914 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.520403e-01 0.818 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 3.551318e-01 0.450 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.943164e-01 0.404 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.943164e-01 0.404 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 1.915471e-01 0.718 0 0
Leukotriene receptors R-HSA-391906 4.311223e-01 0.365 0 0
Nef and signal transduction R-HSA-164944 4.311223e-01 0.365 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.739219e-01 0.562 0 0
Syndecan interactions R-HSA-3000170 2.739219e-01 0.562 0 0
G-protein beta:gamma signalling R-HSA-397795 2.303182e-01 0.638 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.565599e-01 0.448 0 0
Synthesis of PG R-HSA-1483148 3.788518e-01 0.422 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.008123e-01 0.397 0 0
MHC class II antigen presentation R-HSA-2132295 2.453326e-01 0.610 0 0
Diseases of programmed cell death R-HSA-9645723 1.602978e-01 0.795 0 0
Signaling by NOTCH3 R-HSA-9012852 3.608921e-01 0.443 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.223995e-01 0.374 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.642440e-01 0.439 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.404251e-01 0.468 0 0
MTOR signalling R-HSA-165159 3.825734e-01 0.417 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.359921e-01 0.866 1 1
Physiological factors R-HSA-5578768 3.111856e-01 0.507 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.617274e-01 0.791 0 0
Maturation of nucleoprotein R-HSA-9694631 1.920194e-01 0.717 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.405446e-01 0.619 0 0
Neurofascin interactions R-HSA-447043 4.311223e-01 0.365 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.651080e-01 0.782 1 0
Phospholipid metabolism R-HSA-1483257 4.173789e-01 0.379 0 0
Translation of Structural Proteins R-HSA-9694635 4.412002e-01 0.355 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 3.551318e-01 0.450 0 0
Nephron development R-HSA-9831926 4.223995e-01 0.374 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.940324e-01 0.404 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.111856e-01 0.507 0 0
Platelet sensitization by LDL R-HSA-432142 4.223995e-01 0.374 0 0
Translation of Structural Proteins R-HSA-9683701 3.685372e-01 0.434 0 0
Signaling by Leptin R-HSA-2586552 1.964270e-01 0.707 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.223995e-01 0.374 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.907920e-01 0.536 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.435776e-01 0.353 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.564772e-01 0.341 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.570027e-01 0.340 0 0
Striated Muscle Contraction R-HSA-390522 4.579799e-01 0.339 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.579799e-01 0.339 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.579799e-01 0.339 0 0
Miscellaneous transport and binding events R-HSA-5223345 4.579799e-01 0.339 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 4.629341e-01 0.334 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.643168e-01 0.333 0 0
Nephrin family interactions R-HSA-373753 4.643168e-01 0.333 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.656937e-01 0.332 0 0
Netrin mediated repulsion signals R-HSA-418886 4.656937e-01 0.332 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.656937e-01 0.332 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.656937e-01 0.332 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 4.656937e-01 0.332 0 0
Recycling of eIF2:GDP R-HSA-72731 4.656937e-01 0.332 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.656937e-01 0.332 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.656937e-01 0.332 0 0
mRNA Editing: C to U Conversion R-HSA-72200 4.656937e-01 0.332 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.656937e-01 0.332 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.656937e-01 0.332 0 0
Glycoprotein hormones R-HSA-209822 4.656937e-01 0.332 0 0
CHL1 interactions R-HSA-447041 4.656937e-01 0.332 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.656937e-01 0.332 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.673072e-01 0.330 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.692196e-01 0.329 0 0
PKR-mediated signaling R-HSA-9833482 4.737210e-01 0.324 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.739500e-01 0.324 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.745782e-01 0.324 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.775298e-01 0.321 0 0
Stimuli-sensing channels R-HSA-2672351 4.784408e-01 0.320 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.789456e-01 0.320 0 0
ERK/MAPK targets R-HSA-198753 4.845921e-01 0.315 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.845921e-01 0.315 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.862070e-01 0.313 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.862070e-01 0.313 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.897005e-01 0.310 0 0
Oncogene Induced Senescence R-HSA-2559585 4.897005e-01 0.310 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.939193e-01 0.306 0 0
Eukaryotic Translation Termination R-HSA-72764 4.960160e-01 0.305 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.967603e-01 0.304 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.967603e-01 0.304 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.981660e-01 0.303 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.981660e-01 0.303 0 0
MET receptor recycling R-HSA-8875656 4.981660e-01 0.303 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.981660e-01 0.303 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.981660e-01 0.303 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.981660e-01 0.303 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.981660e-01 0.303 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.981660e-01 0.303 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.981660e-01 0.303 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.981660e-01 0.303 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.981660e-01 0.303 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.981660e-01 0.303 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.981660e-01 0.303 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.052164e-01 0.297 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.052164e-01 0.297 0 0
RUNX2 regulates bone development R-HSA-8941326 5.052164e-01 0.297 0 0
GPVI-mediated activation cascade R-HSA-114604 5.052164e-01 0.297 0 0
Kidney development R-HSA-9830369 5.055887e-01 0.296 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.056811e-01 0.296 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.057659e-01 0.296 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.154521e-01 0.288 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.184968e-01 0.285 0 0
Voltage gated Potassium channels R-HSA-1296072 5.204841e-01 0.284 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.204841e-01 0.284 0 0
Cleavage of the damaged purine R-HSA-110331 5.204841e-01 0.284 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.214309e-01 0.283 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.236746e-01 0.281 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.236746e-01 0.281 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 5.236746e-01 0.281 0 0
mTORC1-mediated signalling R-HSA-166208 5.236746e-01 0.281 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.236746e-01 0.281 0 0
Signaling by FGFR R-HSA-190236 5.250698e-01 0.280 0 0
Adherens junctions interactions R-HSA-418990 5.260969e-01 0.279 0 0
Lipophagy R-HSA-9613354 5.286667e-01 0.277 0 0
ALK mutants bind TKIs R-HSA-9700645 5.286667e-01 0.277 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.286667e-01 0.277 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 5.286667e-01 0.277 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.286667e-01 0.277 0 0
ARMS-mediated activation R-HSA-170984 5.286667e-01 0.277 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 5.286667e-01 0.277 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 5.286667e-01 0.277 0 0
Regulated proteolysis of p75NTR R-HSA-193692 5.286667e-01 0.277 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.286667e-01 0.277 0 0
Cell-cell junction organization R-HSA-421270 5.311983e-01 0.275 0 0
Smooth Muscle Contraction R-HSA-445355 5.313655e-01 0.275 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.354916e-01 0.271 0 0
Depurination R-HSA-73927 5.354916e-01 0.271 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.354916e-01 0.271 0 0
Interleukin-17 signaling R-HSA-448424 5.399203e-01 0.268 0 0
Growth hormone receptor signaling R-HSA-982772 5.424535e-01 0.266 0 0
Translation initiation complex formation R-HSA-72649 5.440622e-01 0.264 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.471362e-01 0.262 0 0
Signaling by ALK R-HSA-201556 5.502286e-01 0.259 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.511166e-01 0.259 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.511166e-01 0.259 0 0
Interleukin-1 signaling R-HSA-9020702 5.534693e-01 0.257 0 0
Selenocysteine synthesis R-HSA-2408557 5.534693e-01 0.257 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.573154e-01 0.254 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.573154e-01 0.254 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.573154e-01 0.254 0 0
Formation of apoptosome R-HSA-111458 5.573154e-01 0.254 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 5.573154e-01 0.254 0 0
Regulation of CDH11 function R-HSA-9762292 5.573154e-01 0.254 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.573154e-01 0.254 0 0
Formation of intermediate mesoderm R-HSA-9761174 5.573154e-01 0.254 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.573154e-01 0.254 0 0
Pexophagy R-HSA-9664873 5.573154e-01 0.254 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.573154e-01 0.254 0 0
Maturation of spike protein R-HSA-9683686 5.573154e-01 0.254 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 5.573154e-01 0.254 0 0
Peptide hormone biosynthesis R-HSA-209952 5.573154e-01 0.254 0 0
Deadenylation of mRNA R-HSA-429947 5.607110e-01 0.251 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.607110e-01 0.251 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.621792e-01 0.250 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.689091e-01 0.245 0 0
Signaling by FGFR1 R-HSA-5654736 5.689091e-01 0.245 0 0
Viral mRNA Translation R-HSA-192823 5.719845e-01 0.243 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.784411e-01 0.238 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.784411e-01 0.238 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 5.784411e-01 0.238 0 0
Tight junction interactions R-HSA-420029 5.784411e-01 0.238 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 5.784411e-01 0.238 0 0
G protein gated Potassium channels R-HSA-1296059 5.784411e-01 0.238 0 0
HDMs demethylate histones R-HSA-3214842 5.784411e-01 0.238 0 0
Interleukin-7 signaling R-HSA-1266695 5.784411e-01 0.238 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.788552e-01 0.237 0 0
Maturation of spike protein R-HSA-9694548 5.788552e-01 0.237 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.788552e-01 0.237 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.842243e-01 0.233 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.842243e-01 0.233 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 5.842243e-01 0.233 0 0
Synthesis of PI R-HSA-1483226 5.842243e-01 0.233 0 0
Bicarbonate transporters R-HSA-425381 5.842243e-01 0.233 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.842243e-01 0.233 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.842243e-01 0.233 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.842243e-01 0.233 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 5.842243e-01 0.233 0 0
LGI-ADAM interactions R-HSA-5682910 5.842243e-01 0.233 0 0
Suppression of apoptosis R-HSA-9635465 5.842243e-01 0.233 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.842243e-01 0.233 0 0
Neurotransmitter release cycle R-HSA-112310 5.869657e-01 0.231 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.887375e-01 0.230 0 0
Intra-Golgi traffic R-HSA-6811438 5.927304e-01 0.227 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.927304e-01 0.227 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.929844e-01 0.227 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 5.956406e-01 0.225 0 0
Myogenesis R-HSA-525793 5.956406e-01 0.225 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.956406e-01 0.225 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.990595e-01 0.223 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.047190e-01 0.218 0 0
IRE1alpha activates chaperones R-HSA-381070 6.061859e-01 0.217 0 0
Activation of GABAB receptors R-HSA-991365 6.063058e-01 0.217 0 0
GABA B receptor activation R-HSA-977444 6.063058e-01 0.217 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.063058e-01 0.217 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.094991e-01 0.215 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.094991e-01 0.215 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 6.094991e-01 0.215 0 0
NF-kB is activated and signals survival R-HSA-209560 6.094991e-01 0.215 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 6.094991e-01 0.215 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.094991e-01 0.215 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 6.094991e-01 0.215 0 0
Sodium/Calcium exchangers R-HSA-425561 6.094991e-01 0.215 0 0
Immune System R-HSA-168256 6.115100e-01 0.214 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.122698e-01 0.213 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.123084e-01 0.213 0 0
Packaging Of Telomere Ends R-HSA-171306 6.123084e-01 0.213 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.123084e-01 0.213 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.123084e-01 0.213 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.123084e-01 0.213 0 0
Insulin processing R-HSA-264876 6.123084e-01 0.213 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.153116e-01 0.211 0 0
Signaling by Insulin receptor R-HSA-74752 6.156101e-01 0.211 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 6.156101e-01 0.211 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.162455e-01 0.210 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.162455e-01 0.210 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.162455e-01 0.210 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.162455e-01 0.210 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.162455e-01 0.210 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.162455e-01 0.210 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.165575e-01 0.210 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.195769e-01 0.208 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.260944e-01 0.203 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.275601e-01 0.202 0 0
Telomere Extension By Telomerase R-HSA-171319 6.284455e-01 0.202 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.284455e-01 0.202 0 0
Vesicle-mediated transport R-HSA-5653656 6.290491e-01 0.201 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.325405e-01 0.199 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.332389e-01 0.198 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.332389e-01 0.198 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.332389e-01 0.198 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.332389e-01 0.198 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.332389e-01 0.198 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 6.332389e-01 0.198 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.332389e-01 0.198 0 0
Signaling by LTK R-HSA-9842663 6.332389e-01 0.198 0 0
Repression of WNT target genes R-HSA-4641265 6.332389e-01 0.198 0 0
Estrogen biosynthesis R-HSA-193144 6.332389e-01 0.198 0 0
Interleukin-15 signaling R-HSA-8983432 6.332389e-01 0.198 0 0
Host Interactions of HIV factors R-HSA-162909 6.340648e-01 0.198 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.386596e-01 0.195 0 0
ESR-mediated signaling R-HSA-8939211 6.435832e-01 0.191 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.440549e-01 0.191 0 0
Late endosomal microautophagy R-HSA-9615710 6.440549e-01 0.191 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.440549e-01 0.191 0 0
DNA methylation R-HSA-5334118 6.440549e-01 0.191 0 0
Platelet calcium homeostasis R-HSA-418360 6.440549e-01 0.191 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 6.440549e-01 0.191 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.451940e-01 0.190 1 1
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.451940e-01 0.190 1 0
Signaling by MET R-HSA-6806834 6.453039e-01 0.190 0 0
Autophagy R-HSA-9612973 6.499782e-01 0.187 0 0
Ion channel transport R-HSA-983712 6.515214e-01 0.186 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.520028e-01 0.186 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.549686e-01 0.184 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.555368e-01 0.183 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.555368e-01 0.183 0 0
FGFR1c ligand binding and activation R-HSA-190373 6.555368e-01 0.183 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 6.555368e-01 0.183 0 0
FGFR4 ligand binding and activation R-HSA-190322 6.555368e-01 0.183 0 0
Frs2-mediated activation R-HSA-170968 6.555368e-01 0.183 0 0
Acetylcholine binding and downstream events R-HSA-181431 6.555368e-01 0.183 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.555368e-01 0.183 0 0
Chylomicron remodeling R-HSA-8963901 6.555368e-01 0.183 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 6.555368e-01 0.183 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 6.555368e-01 0.183 0 0
FGFR3 mutant receptor activation R-HSA-2033514 6.555368e-01 0.183 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.555368e-01 0.183 1 1
rRNA modification in the mitochondrion R-HSA-6793080 6.555368e-01 0.183 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 6.555368e-01 0.183 0 0
Interleukin-6 signaling R-HSA-1059683 6.555368e-01 0.183 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.555368e-01 0.183 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.569014e-01 0.182 0 0
Macroautophagy R-HSA-1632852 6.569014e-01 0.182 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 6.574002e-01 0.182 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.575359e-01 0.182 0 0
Diseases of DNA repair R-HSA-9675135 6.575359e-01 0.182 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.575359e-01 0.182 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.591411e-01 0.181 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.591411e-01 0.181 0 0
Activation of the pre-replicative complex R-HSA-68962 6.591411e-01 0.181 0 0
DAP12 signaling R-HSA-2424491 6.591411e-01 0.181 0 0
Neurotransmitter clearance R-HSA-112311 6.591411e-01 0.181 0 0
Ion transport by P-type ATPases R-HSA-936837 6.602027e-01 0.180 0 0
Cellular response to starvation R-HSA-9711097 6.637253e-01 0.178 0 0
Platelet degranulation R-HSA-114608 6.649813e-01 0.177 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.695652e-01 0.174 0 0
Recycling pathway of L1 R-HSA-437239 6.695652e-01 0.174 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.702315e-01 0.174 0 0
Cellular response to hypoxia R-HSA-1234174 6.706424e-01 0.174 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 6.737100e-01 0.172 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 6.737100e-01 0.172 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 6.737100e-01 0.172 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.737100e-01 0.172 0 0
Downstream signal transduction R-HSA-186763 6.737100e-01 0.172 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.764803e-01 0.170 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.764803e-01 0.170 0 0
FGFR3c ligand binding and activation R-HSA-190372 6.764803e-01 0.170 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.764803e-01 0.170 0 0
cGMP effects R-HSA-418457 6.764803e-01 0.170 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.764803e-01 0.170 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.764803e-01 0.170 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 6.764803e-01 0.170 0 0
Glycerophospholipid catabolism R-HSA-6814848 6.764803e-01 0.170 0 0
Non-canonical inflammasome activation R-HSA-9686114 6.764803e-01 0.170 0 0
Signal regulatory protein family interactions R-HSA-391160 6.764803e-01 0.170 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.764803e-01 0.170 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.812821e-01 0.167 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.829358e-01 0.166 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.908519e-01 0.161 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.919114e-01 0.160 0 0
Influenza Infection R-HSA-168255 6.953515e-01 0.158 0 0
Erythropoietin activates RAS R-HSA-9027284 6.961516e-01 0.157 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.961516e-01 0.157 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.961516e-01 0.157 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.961516e-01 0.157 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 6.961516e-01 0.157 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.961516e-01 0.157 0 0
Translesion synthesis by REV1 R-HSA-110312 6.961516e-01 0.157 0 0
Signaling by Activin R-HSA-1502540 6.961516e-01 0.157 0 0
FGFR3 ligand binding and activation R-HSA-190239 6.961516e-01 0.157 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 6.961516e-01 0.157 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.961516e-01 0.157 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.961516e-01 0.157 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.961516e-01 0.157 0 0
Other semaphorin interactions R-HSA-416700 6.961516e-01 0.157 0 0
Protein methylation R-HSA-8876725 6.961516e-01 0.157 0 0
Signaling by WNT R-HSA-195721 6.995338e-01 0.155 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.006205e-01 0.155 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 7.013254e-01 0.154 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.013254e-01 0.154 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 7.013254e-01 0.154 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.013254e-01 0.154 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.013254e-01 0.154 0 0
Adaptive Immune System R-HSA-1280218 7.049297e-01 0.152 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.052683e-01 0.152 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.093366e-01 0.149 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.143891e-01 0.146 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.143891e-01 0.146 0 0
Acyl chain remodelling of PC R-HSA-1482788 7.143891e-01 0.146 0 0
The phototransduction cascade R-HSA-2514856 7.145677e-01 0.146 0 0
Translesion synthesis by POLI R-HSA-5656121 7.146279e-01 0.146 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 7.146279e-01 0.146 0 0
Prolonged ERK activation events R-HSA-169893 7.146279e-01 0.146 0 0
Killing mechanisms R-HSA-9664420 7.146279e-01 0.146 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.146279e-01 0.146 0 0
Activation of SMO R-HSA-5635838 7.146279e-01 0.146 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.146279e-01 0.146 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.146279e-01 0.146 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 7.146279e-01 0.146 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.146279e-01 0.146 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.146279e-01 0.146 0 0
Atorvastatin ADME R-HSA-9754706 7.146279e-01 0.146 0 0
COPII-mediated vesicle transport R-HSA-204005 7.194849e-01 0.143 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.194849e-01 0.143 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.194849e-01 0.143 0 0
Orc1 removal from chromatin R-HSA-68949 7.250474e-01 0.140 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.250474e-01 0.140 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.269697e-01 0.138 0 0
eNOS activation R-HSA-203615 7.269697e-01 0.138 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.269697e-01 0.138 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 7.269697e-01 0.138 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.269697e-01 0.138 0 0
Mitophagy R-HSA-5205647 7.269697e-01 0.138 0 0
Nuclear import of Rev protein R-HSA-180746 7.269697e-01 0.138 0 0
Signaling by NOTCH2 R-HSA-1980145 7.269697e-01 0.138 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.269697e-01 0.138 0 0
Hedgehog 'on' state R-HSA-5632684 7.285818e-01 0.138 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.285818e-01 0.138 0 0
Translesion synthesis by POLK R-HSA-5655862 7.319818e-01 0.135 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.319818e-01 0.135 0 0
Phase 2 - plateau phase R-HSA-5576893 7.319818e-01 0.135 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.319818e-01 0.135 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.319818e-01 0.135 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.319818e-01 0.135 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.319818e-01 0.135 0 0
Passive transport by Aquaporins R-HSA-432047 7.319818e-01 0.135 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.319818e-01 0.135 0 0
Coenzyme A biosynthesis R-HSA-196783 7.319818e-01 0.135 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 7.319818e-01 0.135 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.352238e-01 0.134 0 0
G alpha (i) signalling events R-HSA-418594 7.361141e-01 0.133 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.370195e-01 0.133 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.390775e-01 0.131 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.390775e-01 0.131 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.390775e-01 0.131 0 0
PERK regulates gene expression R-HSA-381042 7.390775e-01 0.131 0 0
Acyl chain remodelling of PE R-HSA-1482839 7.390775e-01 0.131 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.405406e-01 0.130 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.442127e-01 0.128 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.451003e-01 0.128 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.451003e-01 0.128 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.461100e-01 0.127 0 0
Platelet homeostasis R-HSA-418346 7.477363e-01 0.126 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.477363e-01 0.126 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.482814e-01 0.126 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.482814e-01 0.126 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.482814e-01 0.126 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.482814e-01 0.126 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.482814e-01 0.126 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.482814e-01 0.126 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.482814e-01 0.126 0 0
Choline catabolism R-HSA-6798163 7.482814e-01 0.126 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.482814e-01 0.126 0 0
Signaling by NOTCH R-HSA-157118 7.506123e-01 0.125 0 0
HSF1 activation R-HSA-3371511 7.507236e-01 0.125 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.507236e-01 0.125 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.507236e-01 0.125 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.507728e-01 0.124 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.545442e-01 0.122 1 1
Signaling by NOTCH4 R-HSA-9013694 7.545442e-01 0.122 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.546804e-01 0.122 0 0
G alpha (z) signalling events R-HSA-418597 7.546804e-01 0.122 0 0
Cilium Assembly R-HSA-5617833 7.581480e-01 0.120 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.601068e-01 0.119 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.602696e-01 0.119 0 0
Metabolism of RNA R-HSA-8953854 7.613681e-01 0.118 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.619193e-01 0.118 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.619193e-01 0.118 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.627607e-01 0.118 0 0
Toll-like Receptor Cascades R-HSA-168898 7.633873e-01 0.117 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.635906e-01 0.117 0 0
Activated point mutants of FGFR2 R-HSA-2033519 7.635906e-01 0.117 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.635906e-01 0.117 0 0
Mismatch Repair R-HSA-5358508 7.635906e-01 0.117 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.635906e-01 0.117 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.639685e-01 0.117 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.719580e-01 0.112 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.720220e-01 0.112 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.726762e-01 0.112 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.726762e-01 0.112 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.726762e-01 0.112 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.748534e-01 0.111 0 0
TCR signaling R-HSA-202403 7.750267e-01 0.111 0 0
Regulation of signaling by CBL R-HSA-912631 7.779696e-01 0.109 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.779696e-01 0.109 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.779696e-01 0.109 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.779696e-01 0.109 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.779696e-01 0.109 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.779696e-01 0.109 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.816860e-01 0.107 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.816860e-01 0.107 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.830064e-01 0.106 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.830064e-01 0.106 0 0
G2/M Checkpoints R-HSA-69481 7.849399e-01 0.105 1 0
Interleukin-10 signaling R-HSA-6783783 7.861260e-01 0.105 0 0
HCMV Early Events R-HSA-9609690 7.884016e-01 0.103 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.901252e-01 0.102 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 7.914748e-01 0.102 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.914748e-01 0.102 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.914748e-01 0.102 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.914748e-01 0.102 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.914748e-01 0.102 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.914748e-01 0.102 0 0
Signaling by NODAL R-HSA-1181150 7.914748e-01 0.102 0 0
Negative regulation of MET activity R-HSA-6807004 7.914748e-01 0.102 0 0
Pregnenolone biosynthesis R-HSA-196108 7.914748e-01 0.102 0 0
Signal transduction by L1 R-HSA-445144 7.914748e-01 0.102 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.914748e-01 0.102 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.929218e-01 0.101 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.929218e-01 0.101 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.982913e-01 0.098 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.992379e-01 0.097 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.006578e-01 0.097 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.024348e-01 0.096 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.024348e-01 0.096 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.024348e-01 0.096 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.024348e-01 0.096 0 0
Selenoamino acid metabolism R-HSA-2408522 8.034500e-01 0.095 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.041594e-01 0.095 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.041594e-01 0.095 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.041594e-01 0.095 0 0
G-protein activation R-HSA-202040 8.041594e-01 0.095 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.041594e-01 0.095 0 0
Phenylalanine metabolism R-HSA-8964208 8.041594e-01 0.095 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.041594e-01 0.095 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 8.041594e-01 0.095 0 0
Basigin interactions R-HSA-210991 8.041594e-01 0.095 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.076187e-01 0.093 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.115575e-01 0.091 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.115575e-01 0.091 0 0
Signaling by PDGF R-HSA-186797 8.138262e-01 0.089 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.160730e-01 0.088 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.160730e-01 0.088 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.160730e-01 0.088 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.160730e-01 0.088 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.160730e-01 0.088 0 0
Glutathione synthesis and recycling R-HSA-174403 8.160730e-01 0.088 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.160730e-01 0.088 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.160730e-01 0.088 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.160730e-01 0.088 0 0
Circadian clock R-HSA-9909396 8.182657e-01 0.087 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.203023e-01 0.086 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.203023e-01 0.086 0 0
Depyrimidination R-HSA-73928 8.203023e-01 0.086 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.272626e-01 0.082 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.272626e-01 0.082 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.272626e-01 0.082 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.272626e-01 0.082 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.272626e-01 0.082 0 0
Mitochondrial biogenesis R-HSA-1592230 8.282198e-01 0.082 0 0
Defective pyroptosis R-HSA-9710421 8.286813e-01 0.082 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.359474e-01 0.078 0 0
RMTs methylate histone arginines R-HSA-3214858 8.367067e-01 0.077 0 0
DAP12 interactions R-HSA-2172127 8.367067e-01 0.077 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.377721e-01 0.077 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.377721e-01 0.077 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.377721e-01 0.077 0 0
Hemostasis R-HSA-109582 8.421827e-01 0.075 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.428472e-01 0.074 0 0
Nucleosome assembly R-HSA-774815 8.443904e-01 0.073 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.443904e-01 0.073 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.443904e-01 0.073 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.453148e-01 0.073 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.476427e-01 0.072 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.476427e-01 0.072 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.476427e-01 0.072 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.476427e-01 0.072 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.476427e-01 0.072 0 0
Interleukin-6 family signaling R-HSA-6783589 8.476427e-01 0.072 0 0
Nicotinate metabolism R-HSA-196807 8.482754e-01 0.071 0 0
Chromosome Maintenance R-HSA-73886 8.484031e-01 0.071 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.485291e-01 0.071 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.485291e-01 0.071 0 0
G alpha (q) signalling events R-HSA-416476 8.489654e-01 0.071 0 0
Innate Immune System R-HSA-168249 8.494384e-01 0.071 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.517443e-01 0.070 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.517443e-01 0.070 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.517443e-01 0.070 0 0
Ribosome-associated quality control R-HSA-9948299 8.519045e-01 0.070 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.549988e-01 0.068 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.569134e-01 0.067 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.569134e-01 0.067 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.569134e-01 0.067 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.569134e-01 0.067 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.569134e-01 0.067 0 0
Laminin interactions R-HSA-3000157 8.569134e-01 0.067 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.569134e-01 0.067 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.569134e-01 0.067 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.569134e-01 0.067 0 0
Parasite infection R-HSA-9664407 8.605352e-01 0.065 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.605352e-01 0.065 0 0
Leishmania phagocytosis R-HSA-9664417 8.605352e-01 0.065 0 0
Intraflagellar transport R-HSA-5620924 8.655091e-01 0.063 0 0
MET activates PTK2 signaling R-HSA-8874081 8.656205e-01 0.063 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.656205e-01 0.063 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.656205e-01 0.063 0 0
Urea cycle R-HSA-70635 8.656205e-01 0.063 0 0
Abacavir ADME R-HSA-2161522 8.656205e-01 0.063 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.656205e-01 0.063 0 0
Metabolism of cofactors R-HSA-8978934 8.717080e-01 0.060 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.717857e-01 0.060 0 0
DNA Damage Bypass R-HSA-73893 8.719428e-01 0.060 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.737982e-01 0.059 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.737982e-01 0.059 0 0
Cristae formation R-HSA-8949613 8.737982e-01 0.059 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.737982e-01 0.059 0 0
Triglyceride biosynthesis R-HSA-75109 8.737982e-01 0.059 0 0
Synthesis of PE R-HSA-1483213 8.737982e-01 0.059 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.737982e-01 0.059 0 0
Signaling by BMP R-HSA-201451 8.737982e-01 0.059 0 0
Clathrin-mediated endocytosis R-HSA-8856828 8.765650e-01 0.057 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.770423e-01 0.057 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.780921e-01 0.056 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.812277e-01 0.055 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.814787e-01 0.055 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.814787e-01 0.055 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.814787e-01 0.055 0 0
Prednisone ADME R-HSA-9757110 8.814787e-01 0.055 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.814787e-01 0.055 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.814787e-01 0.055 0 0
Interferon Signaling R-HSA-913531 8.820631e-01 0.055 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.839678e-01 0.054 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.839678e-01 0.054 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.848685e-01 0.053 0 0
Inositol phosphate metabolism R-HSA-1483249 8.873358e-01 0.052 0 0
Thyroxine biosynthesis R-HSA-209968 8.886923e-01 0.051 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 8.886923e-01 0.051 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.886923e-01 0.051 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.886923e-01 0.051 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.886923e-01 0.051 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.895803e-01 0.051 0 0
Collagen formation R-HSA-1474290 8.900597e-01 0.051 0 0
SLC transporter disorders R-HSA-5619102 8.924572e-01 0.049 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.949400e-01 0.048 0 0
Nucleotide biosynthesis R-HSA-8956320 8.949400e-01 0.048 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.951199e-01 0.048 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.954672e-01 0.048 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.954672e-01 0.048 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.954672e-01 0.048 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.003644e-01 0.046 0 0
Budding and maturation of HIV virion R-HSA-162588 9.018301e-01 0.045 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.018301e-01 0.045 0 0
Cargo concentration in the ER R-HSA-5694530 9.018301e-01 0.045 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.018301e-01 0.045 0 0
HDACs deacetylate histones R-HSA-3214815 9.049404e-01 0.043 0 0
PCP/CE pathway R-HSA-4086400 9.050950e-01 0.043 0 0
Telomere Maintenance R-HSA-157579 9.060132e-01 0.043 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.072152e-01 0.042 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.096002e-01 0.041 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.096002e-01 0.041 0 0
Peptide hormone metabolism R-HSA-2980736 9.125737e-01 0.040 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.130739e-01 0.039 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.134186e-01 0.039 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 9.134186e-01 0.039 0 0
Synthesis of PA R-HSA-1483166 9.140454e-01 0.039 0 0
Homology Directed Repair R-HSA-5693538 9.157417e-01 0.038 0 0
Dual incision in TC-NER R-HSA-6782135 9.182847e-01 0.037 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 9.186898e-01 0.037 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.186898e-01 0.037 0 0
Heme degradation R-HSA-189483 9.186898e-01 0.037 0 0
Extension of Telomeres R-HSA-180786 9.223269e-01 0.035 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.223269e-01 0.035 1 1
Dual Incision in GG-NER R-HSA-5696400 9.236403e-01 0.034 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.236403e-01 0.034 0 0
Signal amplification R-HSA-392518 9.236403e-01 0.034 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.236403e-01 0.034 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.236403e-01 0.034 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.236403e-01 0.034 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.261801e-01 0.033 0 0
Signalling to ERKs R-HSA-187687 9.282897e-01 0.032 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.282897e-01 0.032 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.290473e-01 0.032 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.298524e-01 0.032 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.326563e-01 0.030 0 0
RNA Polymerase III Transcription R-HSA-74158 9.326563e-01 0.030 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.333515e-01 0.030 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.333515e-01 0.030 0 0
tRNA processing in the nucleus R-HSA-6784531 9.333515e-01 0.030 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.344591e-01 0.029 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.348044e-01 0.029 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.364522e-01 0.029 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.367573e-01 0.028 0 0
NCAM1 interactions R-HSA-419037 9.367573e-01 0.028 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.367573e-01 0.028 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.367573e-01 0.028 0 0
Ovarian tumor domain proteases R-HSA-5689896 9.367573e-01 0.028 0 0
Lysine catabolism R-HSA-71064 9.367573e-01 0.028 0 0
Synthesis of DNA R-HSA-69239 9.397955e-01 0.027 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.422403e-01 0.026 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.428829e-01 0.026 0 0
Stabilization of p53 R-HSA-69541 9.442258e-01 0.025 1 1
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.442258e-01 0.025 0 0
ER-Phagosome pathway R-HSA-1236974 9.445297e-01 0.025 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.457613e-01 0.024 0 0
Base Excision Repair R-HSA-73884 9.470120e-01 0.024 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.476229e-01 0.023 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.476229e-01 0.023 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.476229e-01 0.023 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.476229e-01 0.023 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.476229e-01 0.023 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.476229e-01 0.023 0 0
Interleukin-2 family signaling R-HSA-451927 9.476229e-01 0.023 0 0
Glycogen metabolism R-HSA-8982491 9.476229e-01 0.023 0 0
DNA Double Strand Break Response R-HSA-5693606 9.485011e-01 0.023 1 0
SLC-mediated transport of amino acids R-HSA-9958863 9.485011e-01 0.023 0 0
Metabolism of steroid hormones R-HSA-196071 9.485011e-01 0.023 0 0
HCMV Infection R-HSA-9609646 9.503362e-01 0.022 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.508132e-01 0.022 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.531583e-01 0.021 0 0
SARS-CoV Infections R-HSA-9679506 9.531907e-01 0.021 0 0
Viral Infection Pathways R-HSA-9824446 9.531964e-01 0.021 0 0
rRNA processing R-HSA-72312 9.532575e-01 0.021 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.559428e-01 0.020 0 0
DNA Double-Strand Break Repair R-HSA-5693532 9.563578e-01 0.019 1 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.566232e-01 0.019 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.566232e-01 0.019 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.566232e-01 0.019 0 0
Mitochondrial protein degradation R-HSA-9837999 9.579443e-01 0.019 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.581957e-01 0.019 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.587628e-01 0.018 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.592658e-01 0.018 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.592658e-01 0.018 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.603312e-01 0.018 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.603312e-01 0.018 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.604887e-01 0.018 0 0
Methylation R-HSA-156581 9.617475e-01 0.017 0 0
Ca2+ pathway R-HSA-4086398 9.623618e-01 0.017 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.640031e-01 0.016 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.640782e-01 0.016 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.640782e-01 0.016 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.640782e-01 0.016 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.642925e-01 0.016 0 0
DNA Repair R-HSA-73894 9.643591e-01 0.016 1 0
Interferon gamma signaling R-HSA-877300 9.651758e-01 0.015 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.661277e-01 0.015 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.662670e-01 0.015 0 0
PTEN Regulation R-HSA-6807070 9.667923e-01 0.015 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.676497e-01 0.014 0 0
Interleukin-12 signaling R-HSA-9020591 9.678720e-01 0.014 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.683226e-01 0.014 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.683226e-01 0.014 0 0
Synthesis of PC R-HSA-1483191 9.683226e-01 0.014 0 0
Disease R-HSA-1643685 9.688092e-01 0.014 0 0
ABC-family proteins mediated transport R-HSA-382556 9.697393e-01 0.013 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.702530e-01 0.013 0 0
Metal ion SLC transporters R-HSA-425410 9.702530e-01 0.013 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.709617e-01 0.013 0 0
ABC transporter disorders R-HSA-5619084 9.711048e-01 0.013 0 0
Degradation of CDH1 R-HSA-9766229 9.720659e-01 0.012 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.720659e-01 0.012 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.724864e-01 0.012 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.726012e-01 0.012 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.737684e-01 0.012 0 0
Meiotic recombination R-HSA-912446 9.753672e-01 0.011 0 0
Complex IV assembly R-HSA-9864848 9.753672e-01 0.011 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.761678e-01 0.010 0 0
RSV-host interactions R-HSA-9833110 9.761678e-01 0.010 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.768687e-01 0.010 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.768687e-01 0.010 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.778723e-01 0.010 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.782788e-01 0.010 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.782788e-01 0.010 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.782788e-01 0.010 0 0
Gene Silencing by RNA R-HSA-211000 9.793777e-01 0.009 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.796029e-01 0.009 0 0
Potential therapeutics for SARS R-HSA-9679191 9.797416e-01 0.009 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.797804e-01 0.009 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.808465e-01 0.008 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.812840e-01 0.008 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.820142e-01 0.008 0 0
Digestion R-HSA-8935690 9.820142e-01 0.008 0 0
Interleukin-12 family signaling R-HSA-447115 9.830935e-01 0.007 0 0
Regulation of CDH1 Function R-HSA-9764561 9.831109e-01 0.007 0 0
Dectin-2 family R-HSA-5621480 9.831109e-01 0.007 0 0
PPARA activates gene expression R-HSA-1989781 9.835925e-01 0.007 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.841407e-01 0.007 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.849308e-01 0.007 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.851078e-01 0.007 0 0
Downstream TCR signaling R-HSA-202424 9.856292e-01 0.006 0 0
tRNA Aminoacylation R-HSA-379724 9.860160e-01 0.006 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.860160e-01 0.006 0 0
Glutathione conjugation R-HSA-156590 9.860160e-01 0.006 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.863562e-01 0.006 0 0
Collagen degradation R-HSA-1442490 9.868689e-01 0.006 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.873549e-01 0.006 0 0
Mitochondrial protein import R-HSA-1268020 9.876698e-01 0.005 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.884218e-01 0.005 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.884218e-01 0.005 0 0
Digestion and absorption R-HSA-8963743 9.884218e-01 0.005 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.891281e-01 0.005 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.909900e-01 0.004 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.915481e-01 0.004 0 0
Formation of the cornified envelope R-HSA-6809371 9.919245e-01 0.004 0 0
Visual phototransduction R-HSA-2187338 9.921674e-01 0.003 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.925481e-01 0.003 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.930029e-01 0.003 0 0
Retinoid metabolism and transport R-HSA-975634 9.930029e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.930029e-01 0.003 0 0
Neddylation R-HSA-8951664 9.931487e-01 0.003 0 0
Purine catabolism R-HSA-74259 9.934299e-01 0.003 0 0
Co-inhibition by PD-1 R-HSA-389948 9.935970e-01 0.003 0 0
DNA Replication R-HSA-69306 9.940951e-01 0.003 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.945610e-01 0.002 0 0
Nucleotide Excision Repair R-HSA-5696398 9.946543e-01 0.002 0 0
UCH proteinases R-HSA-5689603 9.948930e-01 0.002 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.948930e-01 0.002 0 0
RNA Polymerase I Transcription R-HSA-73864 9.954975e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.954975e-01 0.002 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.957724e-01 0.002 0 0
Post-translational protein modification R-HSA-597592 9.957945e-01 0.002 0 0
Amyloid fiber formation R-HSA-977225 9.962729e-01 0.002 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.962729e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.963813e-01 0.002 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.969149e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.972661e-01 0.001 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.972803e-01 0.001 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.974464e-01 0.001 0 0
tRNA processing R-HSA-72306 9.975147e-01 0.001 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.976024e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.976024e-01 0.001 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.977489e-01 0.001 0 0
Protein folding R-HSA-391251 9.983575e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.983813e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.986173e-01 0.001 0 0
Mitochondrial translation elongation R-HSA-5389840 9.988018e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.988018e-01 0.001 0 0
HCMV Late Events R-HSA-9610379 9.988036e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.989438e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.989438e-01 0.000 0 0
Translation R-HSA-72766 9.989811e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.990683e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.992296e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.994692e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.995047e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.995635e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.996114e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.996397e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.996609e-01 0.000 0 0
Protein localization R-HSA-9609507 9.997518e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.997954e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.998197e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.998197e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.998842e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.998869e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999022e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999042e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999141e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999149e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999242e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999371e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999422e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999609e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999660e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999776e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999960e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999986e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999993e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999994e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999996e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999997e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999997e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999999e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 6.361578e-14 13.196 1 0
Cellular Senescence R-HSA-2559583 7.216450e-14 13.142 0 0
Cell Cycle, Mitotic R-HSA-69278 1.826317e-13 12.738 0 0
Signal Transduction R-HSA-162582 3.458678e-12 11.461 0 0
M Phase R-HSA-68886 1.138079e-11 10.944 0 0
Cell Cycle Checkpoints R-HSA-69620 1.703138e-11 10.769 1 0
Cellular responses to stress R-HSA-2262752 9.548351e-11 10.020 0 0
Cellular responses to stimuli R-HSA-8953897 3.949407e-10 9.403 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.160627e-09 8.935 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.333105e-09 8.875 0 0
HATs acetylate histones R-HSA-3214847 1.730241e-09 8.762 0 0
Chromatin modifying enzymes R-HSA-3247509 2.145911e-09 8.668 0 0
Chromatin organization R-HSA-4839726 3.853161e-09 8.414 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.682418e-09 8.330 0 0
Nucleosome assembly R-HSA-774815 1.575226e-08 7.803 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.575226e-08 7.803 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.917845e-08 7.717 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.054685e-08 7.687 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.121183e-08 7.673 0 0
Apoptotic execution phase R-HSA-75153 2.245672e-08 7.649 0 0
HDACs deacetylate histones R-HSA-3214815 2.976234e-08 7.526 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.035192e-08 7.518 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.634542e-08 7.440 0 0
Mitotic Prophase R-HSA-68875 4.280154e-08 7.369 0 0
Ub-specific processing proteases R-HSA-5689880 4.784164e-08 7.320 0 0
Mitotic Anaphase R-HSA-68882 4.766517e-08 7.322 0 0
Separation of Sister Chromatids R-HSA-2467813 5.407061e-08 7.267 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.502592e-08 7.259 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.440130e-08 7.264 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.676712e-08 7.062 0 0
Deubiquitination R-HSA-5688426 9.172512e-08 7.038 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.986864e-08 7.001 1 1
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.837758e-07 6.736 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.150009e-07 6.668 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.323326e-07 6.634 0 0
DNA Double Strand Break Response R-HSA-5693606 2.665450e-07 6.574 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.377998e-07 6.471 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.450090e-07 6.462 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.078616e-07 6.389 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.520534e-07 6.345 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.799560e-07 6.319 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.102191e-07 6.292 0 0
Signaling by NOTCH R-HSA-157118 5.497927e-07 6.260 0 0
Axon guidance R-HSA-422475 5.487232e-07 6.261 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.035639e-07 6.219 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.035639e-07 6.219 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.808486e-07 6.167 0 0
Nervous system development R-HSA-9675108 7.628319e-07 6.118 0 0
Cell-Cell communication R-HSA-1500931 8.706940e-07 6.060 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 9.239432e-07 6.034 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.024743e-06 5.989 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.227391e-06 5.911 0 0
Apoptosis R-HSA-109581 1.205276e-06 5.919 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.238674e-06 5.907 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.479668e-06 5.830 0 0
ESR-mediated signaling R-HSA-8939211 1.602123e-06 5.795 0 0
Diseases of programmed cell death R-HSA-9645723 1.605304e-06 5.794 0 0
DNA methylation R-HSA-5334118 2.010006e-06 5.697 0 0
UCH proteinases R-HSA-5689603 2.307715e-06 5.637 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.406275e-06 5.619 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.406275e-06 5.619 0 0
Meiotic synapsis R-HSA-1221632 2.538068e-06 5.595 0 0
Metalloprotease DUBs R-HSA-5689901 2.769057e-06 5.558 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.727754e-06 5.429 1 0
Packaging Of Telomere Ends R-HSA-171306 4.057659e-06 5.392 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.057659e-06 5.392 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.597511e-06 5.252 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.838633e-06 5.234 0 0
Defective pyroptosis R-HSA-9710421 6.348873e-06 5.197 0 0
G2/M Checkpoints R-HSA-69481 7.073412e-06 5.150 1 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.827743e-06 5.106 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.130509e-06 5.090 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 9.576235e-06 5.019 0 0
Cell junction organization R-HSA-446728 1.000415e-05 5.000 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.257633e-05 4.900 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.306281e-05 4.884 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.407883e-05 4.851 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.407883e-05 4.851 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.525721e-05 4.817 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.617791e-05 4.791 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.821724e-05 4.740 0 0
S Phase R-HSA-69242 1.973301e-05 4.705 0 0
Co-inhibition by PD-1 R-HSA-389948 2.005092e-05 4.698 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.226565e-05 4.652 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.441826e-05 4.612 0 0
RNA Polymerase I Transcription R-HSA-73864 2.684203e-05 4.571 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.732295e-05 4.563 0 0
Cellular response to heat stress R-HSA-3371556 2.997914e-05 4.523 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.193803e-05 4.496 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.199567e-05 4.495 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.320087e-05 4.479 1 1
Mitotic Prometaphase R-HSA-68877 3.547459e-05 4.450 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.641024e-05 4.439 0 0
Cleavage of the damaged purine R-HSA-110331 3.641024e-05 4.439 0 0
DNA Replication R-HSA-69306 3.779517e-05 4.423 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.828601e-05 4.417 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.130360e-05 4.384 0 0
Programmed Cell Death R-HSA-5357801 3.914148e-05 4.407 0 0
Homology Directed Repair R-HSA-5693538 4.374327e-05 4.359 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.677894e-05 4.330 0 0
Depurination R-HSA-73927 4.778782e-05 4.321 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.029218e-05 4.220 0 0
Membrane Trafficking R-HSA-199991 6.816474e-05 4.166 0 0
Negative regulation of MET activity R-HSA-6807004 6.856479e-05 4.164 0 0
Oncogene Induced Senescence R-HSA-2559585 7.149852e-05 4.146 0 0
Gene Silencing by RNA R-HSA-211000 7.593689e-05 4.120 0 0
Adherens junctions interactions R-HSA-418990 8.009194e-05 4.096 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 9.282515e-05 4.032 0 0
Signaling by Hippo R-HSA-2028269 9.544836e-05 4.020 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.583990e-05 4.018 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.016656e-04 3.993 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.029178e-04 3.988 0 0
Signaling by ROBO receptors R-HSA-376176 1.040882e-04 3.983 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.042330e-04 3.982 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.066403e-04 3.972 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.208805e-04 3.918 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.300543e-04 3.886 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.302237e-04 3.885 0 0
Chromosome Maintenance R-HSA-73886 1.454232e-04 3.837 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.556023e-04 3.808 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.622684e-04 3.790 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.653750e-04 3.782 0 0
Depyrimidination R-HSA-73928 1.653750e-04 3.782 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.730255e-04 3.762 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.767970e-04 3.753 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.777619e-04 3.750 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.982188e-04 3.703 0 0
EGFR downregulation R-HSA-182971 2.105686e-04 3.677 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.121255e-04 3.673 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.260982e-04 3.646 0 0
Meiosis R-HSA-1500620 2.260982e-04 3.646 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.343481e-04 3.630 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.368077e-04 3.626 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.744152e-04 3.562 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.761611e-04 3.559 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.924670e-04 3.534 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.787349e-04 3.422 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.789819e-04 3.421 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.596388e-04 3.444 0 0
Signaling by EGFR R-HSA-177929 3.794555e-04 3.421 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.861641e-04 3.413 0 0
Meiotic recombination R-HSA-912446 3.899853e-04 3.409 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.325490e-04 3.364 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.563347e-04 3.341 0 0
Cell-cell junction organization R-HSA-421270 5.061092e-04 3.296 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.323185e-04 3.274 0 0
NF-kB is activated and signals survival R-HSA-209560 5.486219e-04 3.261 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.751220e-04 3.240 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.360155e-04 3.271 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.463593e-04 3.263 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.879582e-04 3.231 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.730086e-04 3.242 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.883301e-04 3.230 0 0
Metabolism of RNA R-HSA-8953854 6.513793e-04 3.186 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.619033e-04 3.179 0 0
Amyloid fiber formation R-HSA-977225 6.650931e-04 3.177 0 0
Translation initiation complex formation R-HSA-72649 6.851520e-04 3.164 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 6.851520e-04 3.164 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.914858e-04 3.160 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.180501e-04 3.144 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.240348e-04 3.140 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.304574e-04 3.136 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.385881e-04 3.132 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.562684e-04 3.121 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.732476e-04 3.112 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.833072e-04 3.106 0 0
Signaling by ALK in cancer R-HSA-9700206 7.833072e-04 3.106 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.935501e-04 3.100 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 8.775451e-04 3.057 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.856015e-04 3.053 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.013602e-04 3.045 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 9.189015e-04 3.037 0 0
Peptide chain elongation R-HSA-156902 9.255993e-04 3.034 0 0
Mitotic G2-G2/M phases R-HSA-453274 9.279600e-04 3.032 0 0
DNA Repair R-HSA-73894 9.496966e-04 3.022 1 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.745394e-04 3.011 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 9.745394e-04 3.011 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.908478e-04 3.004 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.074653e-03 2.969 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.074653e-03 2.969 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.074653e-03 2.969 0 0
Signaling by RAS mutants R-HSA-6802949 1.074653e-03 2.969 0 0
MAP2K and MAPK activation R-HSA-5674135 1.105735e-03 2.956 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.105735e-03 2.956 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.135481e-03 2.945 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.232954e-03 2.909 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.428050e-03 2.845 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.328955e-03 2.876 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.402554e-03 2.853 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.358313e-03 2.867 0 0
Influenza Infection R-HSA-168255 1.305044e-03 2.884 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.476084e-03 2.831 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.567099e-03 2.805 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.571434e-03 2.804 0 0
Interleukin-12 signaling R-HSA-9020591 1.647410e-03 2.783 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.676331e-03 2.776 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.676331e-03 2.776 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.720373e-03 2.764 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.729839e-03 2.762 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.792841e-03 2.746 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.816537e-03 2.741 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.816537e-03 2.741 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.842303e-03 2.735 1 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.842303e-03 2.735 1 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.842303e-03 2.735 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.874756e-03 2.727 0 0
Attenuation phase R-HSA-3371568 2.033942e-03 2.692 0 0
Reproduction R-HSA-1474165 2.085409e-03 2.681 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.404963e-03 2.619 0 0
mTORC1-mediated signalling R-HSA-166208 2.427991e-03 2.615 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.379251e-03 2.624 0 0
NRAGE signals death through JNK R-HSA-193648 2.379251e-03 2.624 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.404807e-03 2.619 0 0
p75NTR signals via NF-kB R-HSA-193639 2.404963e-03 2.619 0 0
Signaling by WNT R-HSA-195721 2.251985e-03 2.647 0 0
G2/M Transition R-HSA-69275 2.382800e-03 2.623 0 0
FLT3 Signaling R-HSA-9607240 2.452484e-03 2.610 0 0
Base Excision Repair R-HSA-73884 2.548123e-03 2.594 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.557084e-03 2.592 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.559744e-03 2.592 0 0
HSF1-dependent transactivation R-HSA-3371571 2.574947e-03 2.589 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.589282e-03 2.587 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.765032e-03 2.558 0 0
Regulation of CDH1 Function R-HSA-9764561 2.777625e-03 2.556 0 0
Signaling by MET R-HSA-6806834 2.818578e-03 2.550 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.856270e-03 2.544 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.875439e-03 2.541 0 0
Semaphorin interactions R-HSA-373755 2.937829e-03 2.532 0 0
PTEN Regulation R-HSA-6807070 2.986600e-03 2.525 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.610803e-03 2.442 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.270813e-03 2.485 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.270813e-03 2.485 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.268641e-03 2.486 0 0
Cellular response to starvation R-HSA-9711097 3.200600e-03 2.495 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.610803e-03 2.442 0 0
Telomere Maintenance R-HSA-157579 3.609665e-03 2.443 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.581384e-03 2.446 0 0
Host Interactions of HIV factors R-HSA-162909 3.272218e-03 2.485 0 0
Developmental Biology R-HSA-1266738 3.281747e-03 2.484 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.330115e-03 2.478 0 0
Interleukin-12 family signaling R-HSA-447115 3.644437e-03 2.438 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.924549e-03 2.406 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.924549e-03 2.406 0 0
Neurodegenerative Diseases R-HSA-8863678 3.924549e-03 2.406 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.029585e-03 2.395 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.361038e-03 2.360 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 4.361038e-03 2.360 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.414972e-03 2.355 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.414972e-03 2.355 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.439441e-03 2.353 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.516136e-03 2.345 0 0
G alpha (12/13) signalling events R-HSA-416482 4.608199e-03 2.336 0 0
Nuclear import of Rev protein R-HSA-180746 4.685188e-03 2.329 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.770579e-03 2.321 0 0
Signaling by NOTCH3 R-HSA-9012852 4.770579e-03 2.321 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.856379e-03 2.314 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.856379e-03 2.314 0 0
Ribosome-associated quality control R-HSA-9948299 4.884432e-03 2.311 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.951936e-03 2.305 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.977404e-03 2.303 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.197907e-03 2.284 0 0
HCMV Early Events R-HSA-9609690 5.208920e-03 2.283 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.247948e-03 2.280 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.277501e-03 2.278 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.277501e-03 2.278 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.285095e-03 2.277 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.285095e-03 2.277 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.285095e-03 2.277 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.336626e-03 2.273 0 0
MAPK family signaling cascades R-HSA-5683057 5.351628e-03 2.272 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 6.278184e-03 2.202 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 6.278184e-03 2.202 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.039933e-03 2.219 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.039933e-03 2.219 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.908394e-03 2.229 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.908394e-03 2.229 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.626870e-03 2.250 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.672898e-03 2.246 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.993757e-03 2.222 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.065713e-03 2.217 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.499273e-03 2.187 1 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.690654e-03 2.245 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.237657e-03 2.205 0 0
Protein ubiquitination R-HSA-8852135 6.614898e-03 2.179 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.673630e-03 2.176 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.673630e-03 2.176 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.702234e-03 2.174 0 0
HSF1 activation R-HSA-3371511 6.712840e-03 2.173 0 0
FLT3 signaling in disease R-HSA-9682385 6.712840e-03 2.173 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.782864e-03 2.169 0 0
Death Receptor Signaling R-HSA-73887 6.827312e-03 2.166 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.038427e-03 2.153 0 0
EPH-Ephrin signaling R-HSA-2682334 7.158357e-03 2.145 0 0
G1/S Transition R-HSA-69206 7.183938e-03 2.144 0 0
HIV Infection R-HSA-162906 7.328082e-03 2.135 0 0
Polo-like kinase mediated events R-HSA-156711 7.357921e-03 2.133 0 0
Ephrin signaling R-HSA-3928664 7.357921e-03 2.133 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.357921e-03 2.133 1 1
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.390710e-03 2.131 0 0
Signaling by NOTCH1 R-HSA-1980143 7.448751e-03 2.128 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.455236e-03 2.128 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.467174e-03 2.127 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.495155e-03 2.125 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.555876e-03 2.122 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.653054e-03 2.116 0 0
Regulation of PTEN localization R-HSA-8948747 7.653054e-03 2.116 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.957596e-03 2.099 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 7.957596e-03 2.099 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.100979e-03 2.091 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.810553e-03 2.055 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.810553e-03 2.055 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 8.544271e-03 2.068 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.544271e-03 2.068 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 8.544271e-03 2.068 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.016423e-02 1.993 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.016423e-02 1.993 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.682387e-03 2.014 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.682387e-03 2.014 0 0
MTOR signalling R-HSA-165159 8.572468e-03 2.067 0 0
Rap1 signalling R-HSA-392517 9.339047e-03 2.030 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.443198e-03 2.025 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.443198e-03 2.025 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.443198e-03 2.025 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.443198e-03 2.025 0 0
HIV Life Cycle R-HSA-162587 8.650139e-03 2.063 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.810553e-03 2.055 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 9.376081e-03 2.028 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.287360e-03 2.032 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.443198e-03 2.025 0 0
HCMV Late Events R-HSA-9610379 8.650139e-03 2.063 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.016423e-02 1.993 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.023416e-02 1.990 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.062464e-02 1.974 0 0
Eukaryotic Translation Termination R-HSA-72764 1.076923e-02 1.968 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.088179e-02 1.963 0 0
Late endosomal microautophagy R-HSA-9615710 1.088179e-02 1.963 0 0
Stabilization of p53 R-HSA-69541 1.098358e-02 1.959 1 1
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.103068e-02 1.957 0 0
Synthesis of DNA R-HSA-69239 1.103068e-02 1.957 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.119412e-02 1.951 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.119412e-02 1.951 0 0
Formation of annular gap junctions R-HSA-196025 1.119412e-02 1.951 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.141077e-02 1.943 0 0
Deadenylation of mRNA R-HSA-429947 1.143923e-02 1.942 0 0
G1 Phase R-HSA-69236 1.154403e-02 1.938 0 0
Cyclin D associated events in G1 R-HSA-69231 1.154403e-02 1.938 0 0
RMTs methylate histone arginines R-HSA-3214858 1.154403e-02 1.938 0 0
Gene expression (Transcription) R-HSA-74160 1.174738e-02 1.930 1 0
Signaling by NOTCH4 R-HSA-9013694 1.189180e-02 1.925 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.279562e-02 1.893 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.282624e-02 1.892 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.282624e-02 1.892 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.282624e-02 1.892 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.282624e-02 1.892 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.282624e-02 1.892 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.282624e-02 1.892 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.282624e-02 1.892 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.282624e-02 1.892 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.282624e-02 1.892 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.282624e-02 1.892 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.282624e-02 1.892 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.296961e-02 1.887 0 0
Interleukin-37 signaling R-HSA-9008059 1.299998e-02 1.886 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.358235e-02 1.867 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.366043e-02 1.865 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.366043e-02 1.865 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.366043e-02 1.865 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.366043e-02 1.865 0 0
Regulation of Apoptosis R-HSA-169911 1.410100e-02 1.851 0 0
TCR signaling R-HSA-202403 1.442919e-02 1.841 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.452522e-02 1.838 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.482785e-02 1.829 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.501683e-02 1.823 0 0
Signaling by Interleukins R-HSA-449147 1.537394e-02 1.813 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.541364e-02 1.812 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.541364e-02 1.812 0 0
Gap junction degradation R-HSA-190873 1.571358e-02 1.804 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.648252e-02 1.783 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.648252e-02 1.783 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.648252e-02 1.783 0 0
Maturation of protein E R-HSA-9683683 1.648252e-02 1.783 0 0
Maturation of protein E R-HSA-9694493 1.648252e-02 1.783 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.709592e-02 1.767 0 0
Regulation of TP53 Activity R-HSA-5633007 1.762912e-02 1.754 1 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.781574e-02 1.749 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.781574e-02 1.749 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.781574e-02 1.749 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.820272e-02 1.740 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.447040e-02 1.611 0 0
MET interacts with TNS proteins R-HSA-8875513 2.296034e-02 1.639 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.296034e-02 1.639 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.407893e-02 1.618 0 0
Notch-HLH transcription pathway R-HSA-350054 2.135567e-02 1.670 0 0
Integrin signaling R-HSA-354192 2.121762e-02 1.673 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.961540e-02 1.707 0 0
Viral mRNA Translation R-HSA-192823 2.230896e-02 1.652 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.343815e-02 1.630 1 1
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.128972e-02 1.672 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.128972e-02 1.672 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.128972e-02 1.672 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.130989e-02 1.671 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.961540e-02 1.707 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.089022e-02 1.680 0 0
MAP kinase activation R-HSA-450294 2.187893e-02 1.660 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.240158e-02 1.650 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.146185e-02 1.668 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.276353e-02 1.643 0 0
tRNA processing in the nucleus R-HSA-6784531 2.440970e-02 1.612 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.130989e-02 1.671 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.135567e-02 1.670 0 0
Pexophagy R-HSA-9664873 2.130989e-02 1.671 0 0
Selenocysteine synthesis R-HSA-2408557 1.878901e-02 1.726 0 0
Striated Muscle Contraction R-HSA-390522 2.465161e-02 1.608 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.465161e-02 1.608 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.546943e-02 1.594 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.556107e-02 1.592 0 0
Vesicle-mediated transport R-HSA-5653656 2.605856e-02 1.584 0 0
Signaling by PTK6 R-HSA-8848021 2.715309e-02 1.566 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.715309e-02 1.566 0 0
Regulation of signaling by CBL R-HSA-912631 2.742625e-02 1.562 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.742625e-02 1.562 0 0
Signaling by TGFB family members R-HSA-9006936 2.784835e-02 1.555 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.789377e-02 1.554 0 0
HCMV Infection R-HSA-9609646 2.803913e-02 1.552 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.806443e-02 1.552 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.846796e-02 1.546 0 0
Signaling by NOTCH2 R-HSA-1980145 2.846796e-02 1.546 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.846796e-02 1.546 0 0
DCC mediated attractive signaling R-HSA-418885 2.855952e-02 1.544 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.883342e-02 1.540 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.884623e-02 1.540 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.887272e-02 1.540 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.906593e-02 1.537 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.181680e-02 1.497 0 0
Orc1 removal from chromatin R-HSA-68949 3.189799e-02 1.496 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 3.189799e-02 1.496 0 0
Activation of BH3-only proteins R-HSA-114452 3.193972e-02 1.496 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.214098e-02 1.493 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.223826e-02 1.492 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.250742e-02 1.488 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.268601e-02 1.486 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.281369e-02 1.484 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.305158e-02 1.481 0 0
Nephrin family interactions R-HSA-373753 3.305158e-02 1.481 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.348621e-02 1.475 0 0
Signaling by VEGF R-HSA-194138 3.487250e-02 1.458 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.525064e-02 1.453 0 0
Phosphorylation of the APC/C R-HSA-176412 3.525064e-02 1.453 0 0
Prolonged ERK activation events R-HSA-169893 3.525064e-02 1.453 0 0
Regulation of BACH1 activity R-HSA-9708530 3.525064e-02 1.453 0 0
Negative regulation of FLT3 R-HSA-9706369 3.525064e-02 1.453 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.563505e-02 1.448 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.603987e-02 1.443 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.603987e-02 1.443 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.603987e-02 1.443 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.638522e-02 1.439 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.638522e-02 1.439 0 0
Recycling pathway of L1 R-HSA-437239 3.650459e-02 1.438 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.712112e-02 1.430 0 0
Kinesins R-HSA-983189 3.823075e-02 1.418 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.939720e-02 1.405 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.939720e-02 1.405 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.939720e-02 1.405 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.939720e-02 1.405 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.939720e-02 1.405 0 0
Interleukin-1 family signaling R-HSA-446652 4.038279e-02 1.394 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.161473e-02 1.381 1 0
Cytokine Signaling in Immune system R-HSA-1280215 4.184815e-02 1.378 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.239742e-02 1.373 0 0
Degradation of DVL R-HSA-4641258 4.239742e-02 1.373 0 0
Degradation of AXIN R-HSA-4641257 4.239742e-02 1.373 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.287421e-02 1.368 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.287421e-02 1.368 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.418893e-02 1.355 0 0
Type I hemidesmosome assembly R-HSA-446107 4.475432e-02 1.349 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.475432e-02 1.349 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.475432e-02 1.349 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.475432e-02 1.349 0 0
Modulation by Mtb of host immune system R-HSA-9637628 4.475432e-02 1.349 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.527932e-02 1.344 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 4.527932e-02 1.344 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 4.527932e-02 1.344 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.648631e-02 1.333 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.648959e-02 1.333 0 0
Cellular response to chemical stress R-HSA-9711123 4.699793e-02 1.328 0 0
Viral Infection Pathways R-HSA-9824446 4.800391e-02 1.319 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.856280e-02 1.314 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.094136e-02 1.293 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.145740e-02 1.289 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.145740e-02 1.289 0 0
Specification of primordial germ cells R-HSA-9827857 5.145740e-02 1.289 0 0
RNA Polymerase II Transcription R-HSA-73857 5.250426e-02 1.280 1 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.301850e-02 1.276 0 0
IRS activation R-HSA-74713 5.301850e-02 1.276 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.301850e-02 1.276 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.301850e-02 1.276 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.301850e-02 1.276 0 0
Interleukin-17 signaling R-HSA-448424 5.306331e-02 1.275 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.331491e-02 1.273 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.390954e-02 1.268 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.390954e-02 1.268 1 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 5.390954e-02 1.268 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.434914e-02 1.265 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.496828e-02 1.260 0 0
Frs2-mediated activation R-HSA-170968 5.580626e-02 1.253 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.580626e-02 1.253 0 0
Regulation of TP53 Expression R-HSA-6804754 8.385989e-02 1.076 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 8.385989e-02 1.076 0 0
Signalling to ERK5 R-HSA-198765 8.385989e-02 1.076 0 0
Regulation of cortical dendrite branching R-HSA-8985801 8.385989e-02 1.076 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 8.385989e-02 1.076 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.266559e-02 1.139 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.788826e-02 1.237 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.788826e-02 1.237 0 0
ALK mutants bind TKIs R-HSA-9700645 5.788826e-02 1.237 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.285292e-02 1.138 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.072181e-02 1.093 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.072181e-02 1.093 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.101698e-02 1.215 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.308056e-02 1.081 0 0
Dual Incision in GG-NER R-HSA-5696400 6.206576e-02 1.207 0 0
G1/S-Specific Transcription R-HSA-69205 7.793917e-02 1.108 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.474886e-02 1.126 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.474886e-02 1.126 0 0
AURKA Activation by TPX2 R-HSA-8854518 6.656462e-02 1.177 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.971288e-02 1.098 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.030751e-02 1.220 0 0
Signaling by ERBB2 R-HSA-1227986 7.043318e-02 1.152 0 0
PERK regulates gene expression R-HSA-381042 6.972089e-02 1.157 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.827717e-02 1.235 1 1
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.827717e-02 1.235 1 0
TGFBR3 expression R-HSA-9839394 8.263977e-02 1.083 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.972089e-02 1.157 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 6.731567e-02 1.172 0 0
Mismatch Repair R-HSA-5358508 6.101698e-02 1.215 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.308707e-02 1.200 0 0
Translesion synthesis by REV1 R-HSA-110312 8.072181e-02 1.093 0 0
Budding and maturation of HIV virion R-HSA-162588 8.069791e-02 1.093 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.793917e-02 1.108 1 1
Deadenylation-dependent mRNA decay R-HSA-429914 6.445171e-02 1.191 0 0
Interferon Signaling R-HSA-913531 7.336587e-02 1.135 0 0
Neurexins and neuroligins R-HSA-6794361 6.173444e-02 1.209 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.972089e-02 1.157 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.101698e-02 1.215 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.862160e-02 1.232 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.156272e-02 1.145 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 8.385989e-02 1.076 0 0
Josephin domain DUBs R-HSA-5689877 7.285292e-02 1.138 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.069791e-02 1.093 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.037132e-02 1.219 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.793917e-02 1.108 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.827717e-02 1.235 0 0
Metabolism of non-coding RNA R-HSA-194441 6.445171e-02 1.191 0 0
snRNP Assembly R-HSA-191859 6.445171e-02 1.191 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.676574e-02 1.115 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.928673e-02 1.159 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.676574e-02 1.115 0 0
Smooth Muscle Contraction R-HSA-445355 6.789335e-02 1.168 0 0
L1CAM interactions R-HSA-373760 7.112258e-02 1.148 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.206576e-02 1.207 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 6.101698e-02 1.215 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.072181e-02 1.093 0 0
Signaling by Leptin R-HSA-2586552 7.285292e-02 1.138 0 0
SARS-CoV Infections R-HSA-9679506 6.501427e-02 1.187 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.119132e-02 1.090 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.515165e-02 1.070 0 0
DNA Damage Bypass R-HSA-73893 8.616756e-02 1.065 0 0
Degradation of CDH1 R-HSA-9766229 8.616756e-02 1.065 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.957862e-02 1.048 0 0
PECAM1 interactions R-HSA-210990 8.957862e-02 1.048 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.049672e-02 1.043 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.049672e-02 1.043 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.170147e-02 1.038 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.279890e-02 1.032 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.364497e-02 1.029 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.364497e-02 1.029 0 0
Myogenesis R-HSA-525793 9.364497e-02 1.029 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.364497e-02 1.029 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.364497e-02 1.029 0 0
Nef and signal transduction R-HSA-164944 9.505611e-02 1.022 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 9.506603e-02 1.022 0 0
Translesion synthesis by POLI R-HSA-5656121 9.506603e-02 1.022 0 0
Generic Transcription Pathway R-HSA-212436 9.514117e-02 1.022 1 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.556709e-02 1.020 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.872630e-02 1.006 0 0
Hedgehog 'on' state R-HSA-5632684 9.880035e-02 1.005 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 9.925278e-02 1.003 0 0
Protein-protein interactions at synapses R-HSA-6794362 9.934675e-02 1.003 0 0
mRNA Splicing R-HSA-72172 1.000652e-01 1.000 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.009412e-01 0.996 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.009412e-01 0.996 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.027348e-01 0.988 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.031915e-01 0.986 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.031915e-01 0.986 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.054241e-01 0.977 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.054241e-01 0.977 0 0
Cellular response to hypoxia R-HSA-1234174 1.056581e-01 0.976 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.066612e-01 0.972 0 0
Activation of RAC1 R-HSA-428540 1.079668e-01 0.967 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.089960e-01 0.963 0 0
Assembly Of The HIV Virion R-HSA-175474 1.089960e-01 0.963 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.089960e-01 0.963 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.089960e-01 0.963 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.094143e-01 0.961 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.094644e-01 0.961 0 0
Translesion synthesis by POLK R-HSA-5655862 1.106119e-01 0.956 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.106119e-01 0.956 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.116735e-01 0.952 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.116735e-01 0.952 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.128427e-01 0.948 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.128427e-01 0.948 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.128427e-01 0.948 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.128427e-01 0.948 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.139798e-01 0.943 0 0
Rab regulation of trafficking R-HSA-9007101 1.139831e-01 0.943 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.161888e-01 0.935 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.170100e-01 0.932 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.179602e-01 0.928 0 0
Recycling of eIF2:GDP R-HSA-72731 1.198723e-01 0.921 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.198723e-01 0.921 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.198723e-01 0.921 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.210440e-01 0.917 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.210440e-01 0.917 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.214353e-01 0.916 0 0
MET activates PTPN11 R-HSA-8865999 1.214353e-01 0.916 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.214353e-01 0.916 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.214353e-01 0.916 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.222442e-01 0.913 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.233359e-01 0.909 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.237633e-01 0.907 0 0
Glycolysis R-HSA-70171 1.254144e-01 0.902 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 1.273003e-01 0.895 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.273003e-01 0.895 0 0
Glycogen storage diseases R-HSA-3229121 1.273003e-01 0.895 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.274522e-01 0.895 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.274522e-01 0.895 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.278958e-01 0.893 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.278958e-01 0.893 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.278958e-01 0.893 0 0
Repression of WNT target genes R-HSA-4641265 1.278958e-01 0.893 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.278958e-01 0.893 0 0
Regulation of IFNG signaling R-HSA-877312 1.278958e-01 0.893 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.278958e-01 0.893 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.296719e-01 0.887 0 0
Centrosome maturation R-HSA-380287 1.304572e-01 0.885 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.304572e-01 0.885 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.312306e-01 0.882 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.312306e-01 0.882 0 0
Interleukin-1 signaling R-HSA-9020702 1.326928e-01 0.877 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.385475e-01 0.858 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.389911e-01 0.857 0 0
Downstream TCR signaling R-HSA-202424 1.444766e-01 0.840 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.450607e-01 0.838 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.452076e-01 0.838 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.467710e-01 0.833 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.467710e-01 0.833 0 0
GPVI-mediated activation cascade R-HSA-114604 1.490458e-01 0.827 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.492261e-01 0.826 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.492261e-01 0.826 0 0
Interleukin-6 signaling R-HSA-1059683 1.492261e-01 0.826 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.492261e-01 0.826 1 1
RNA Polymerase I Transcription Initiation R-HSA-73762 1.510457e-01 0.821 0 0
Autophagy R-HSA-9612973 1.519468e-01 0.818 0 0
Thromboxane signalling through TP receptor R-HSA-428930 1.545846e-01 0.811 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.545846e-01 0.811 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.577604e-01 0.802 0 0
Regulation of gap junction activity R-HSA-191650 1.621986e-01 0.790 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.621986e-01 0.790 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.621986e-01 0.790 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.621986e-01 0.790 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.621986e-01 0.790 0 0
MTF1 activates gene expression R-HSA-5660489 1.621986e-01 0.790 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.129578e-01 0.672 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.129578e-01 0.672 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.129578e-01 0.672 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.129578e-01 0.672 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.129578e-01 0.672 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.129578e-01 0.672 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.129578e-01 0.672 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.129578e-01 0.672 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.129578e-01 0.672 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.129578e-01 0.672 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.017801e-01 0.520 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.017801e-01 0.520 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.017801e-01 0.520 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.017801e-01 0.520 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.017801e-01 0.520 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.017801e-01 0.520 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.017801e-01 0.520 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.017801e-01 0.520 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.017801e-01 0.520 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.017801e-01 0.520 0 0
Reelin signalling pathway R-HSA-8866376 2.049527e-01 0.688 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.049527e-01 0.688 0 0
G2 Phase R-HSA-68911 2.049527e-01 0.688 0 0
ARMS-mediated activation R-HSA-170984 1.754004e-01 0.756 0 0
Lipophagy R-HSA-9613354 1.754004e-01 0.756 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.754004e-01 0.756 0 0
Calcineurin activates NFAT R-HSA-2025928 1.754004e-01 0.756 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.487299e-01 0.604 0 0
Phosphorylation of Emi1 R-HSA-176417 2.487299e-01 0.604 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.487299e-01 0.604 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.487299e-01 0.604 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.487299e-01 0.604 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.487299e-01 0.604 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.927554e-01 0.533 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.927554e-01 0.533 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.927554e-01 0.533 0 0
STAT5 Activation R-HSA-9645135 2.927554e-01 0.533 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.954743e-01 0.709 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.954743e-01 0.709 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.682661e-01 0.571 0 0
Polymerase switching R-HSA-69091 3.004998e-01 0.522 0 0
Leading Strand Synthesis R-HSA-69109 3.004998e-01 0.522 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.071028e-01 0.684 0 0
HIV elongation arrest and recovery R-HSA-167287 2.258736e-01 0.646 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.258736e-01 0.646 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.977570e-01 0.526 0 0
RAF activation R-HSA-5673000 2.244208e-01 0.649 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.244208e-01 0.649 0 0
Dual incision in TC-NER R-HSA-6782135 1.741024e-01 0.759 0 0
mRNA 3'-end processing R-HSA-72187 1.882541e-01 0.725 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.040259e-01 0.690 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.649145e-01 0.577 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.919362e-01 0.535 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.244318e-01 0.489 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.244318e-01 0.489 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.244318e-01 0.489 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.850462e-01 0.545 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.149687e-01 0.502 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.149687e-01 0.502 0 0
MET promotes cell motility R-HSA-8875878 2.963016e-01 0.528 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.780003e-01 0.556 0 0
PKR-mediated signaling R-HSA-9833482 1.771118e-01 0.752 0 0
Nucleotide Excision Repair R-HSA-5696398 1.726131e-01 0.763 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.659088e-01 0.575 0 0
FOXO-mediated transcription R-HSA-9614085 2.510755e-01 0.600 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.244208e-01 0.649 0 0
Killing mechanisms R-HSA-9664420 2.200674e-01 0.657 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 2.200674e-01 0.657 0 0
G0 and Early G1 R-HSA-1538133 1.751475e-01 0.757 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.026962e-01 0.519 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.874871e-01 0.541 0 0
Translesion Synthesis by POLH R-HSA-110320 3.244318e-01 0.489 0 0
Aggrephagy R-HSA-9646399 2.062364e-01 0.686 0 0
DNA strand elongation R-HSA-69190 3.054927e-01 0.515 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.992460e-01 0.701 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.910335e-01 0.719 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.469109e-01 0.607 0 0
GAB1 signalosome R-HSA-180292 2.977570e-01 0.526 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.754004e-01 0.756 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.909878e-01 0.719 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.674280e-01 0.776 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.954743e-01 0.709 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.451671e-01 0.611 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.085391e-01 0.681 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.674280e-01 0.776 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.674280e-01 0.776 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.638130e-01 0.786 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.469109e-01 0.607 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.802083e-01 0.744 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.651282e-01 0.782 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.889216e-01 0.724 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.625565e-01 0.789 0 0
PCP/CE pathway R-HSA-4086400 2.369095e-01 0.625 0 0
Developmental Cell Lineages R-HSA-9734767 1.645410e-01 0.784 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.034296e-01 0.692 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.476100e-01 0.606 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.049527e-01 0.688 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.049527e-01 0.688 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.754004e-01 0.756 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.718057e-01 0.765 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.901119e-01 0.721 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.423099e-01 0.616 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.692174e-01 0.570 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.454200e-01 0.610 0 0
Circadian clock R-HSA-9909396 1.811869e-01 0.742 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.623109e-01 0.790 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.697329e-01 0.770 0 0
Signal attenuation R-HSA-74749 2.054128e-01 0.687 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.927554e-01 0.533 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.244208e-01 0.649 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.217384e-01 0.654 0 0
TBC/RABGAPs R-HSA-8854214 2.705664e-01 0.568 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.074733e-01 0.683 0 0
Selective autophagy R-HSA-9663891 2.780003e-01 0.556 0 0
Glycogen synthesis R-HSA-3322077 1.834694e-01 0.736 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.244318e-01 0.489 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.220552e-01 0.492 0 0
rRNA processing R-HSA-72312 2.102376e-01 0.677 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.771118e-01 0.752 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.012085e-01 0.696 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.850462e-01 0.545 0 0
Signaling by SCF-KIT R-HSA-1433557 2.705664e-01 0.568 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.451671e-01 0.611 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.910335e-01 0.719 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.330361e-01 0.633 0 0
Macroautophagy R-HSA-1632852 2.672488e-01 0.573 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.062364e-01 0.686 0 0
Adaptive Immune System R-HSA-1280218 2.101586e-01 0.677 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.040259e-01 0.690 0 0
Inhibition of PKR R-HSA-169131 2.129578e-01 0.672 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.017801e-01 0.520 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 3.017801e-01 0.520 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.017801e-01 0.520 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.017801e-01 0.520 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.754004e-01 0.756 0 0
Bicarbonate transporters R-HSA-425381 2.364731e-01 0.626 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.200674e-01 0.657 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.150390e-01 0.502 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.160796e-01 0.500 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.534860e-01 0.596 0 0
HDMs demethylate histones R-HSA-3214842 3.149687e-01 0.502 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.244208e-01 0.649 0 0
Heme signaling R-HSA-9707616 2.232668e-01 0.651 0 0
TNF signaling R-HSA-75893 2.421868e-01 0.616 0 0
Muscle contraction R-HSA-397014 2.936034e-01 0.532 0 0
Signaling by ERBB4 R-HSA-1236394 1.909878e-01 0.719 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.754004e-01 0.756 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 2.710324e-01 0.567 0 0
Signaling by TGFBR3 R-HSA-9839373 2.040259e-01 0.690 0 0
Netrin-1 signaling R-HSA-373752 1.766277e-01 0.753 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.901119e-01 0.721 0 0
DAG and IP3 signaling R-HSA-1489509 3.046635e-01 0.516 0 0
Inhibition of membrane repair R-HSA-9635644 3.017801e-01 0.520 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.017801e-01 0.520 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.364731e-01 0.626 0 0
RET signaling R-HSA-8853659 2.596443e-01 0.586 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.258736e-01 0.646 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.054128e-01 0.687 0 0
Mitophagy R-HSA-5205647 2.244208e-01 0.649 0 0
Signal regulatory protein family interactions R-HSA-391160 1.718057e-01 0.765 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.635981e-01 0.786 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.150390e-01 0.502 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.039366e-01 0.691 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.756883e-01 0.755 0 0
Diseases of DNA repair R-HSA-9675135 3.220552e-01 0.492 0 0
Co-inhibition by BTLA R-HSA-9927353 2.049527e-01 0.688 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.487299e-01 0.604 0 0
Downstream signal transduction R-HSA-186763 2.850462e-01 0.545 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.739112e-01 0.562 0 0
Glucose metabolism R-HSA-70326 3.110265e-01 0.507 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.889216e-01 0.724 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.901119e-01 0.721 0 0
ABC-family proteins mediated transport R-HSA-382556 2.620480e-01 0.582 0 0
Growth hormone receptor signaling R-HSA-982772 2.692174e-01 0.570 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.487299e-01 0.604 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.220422e-01 0.492 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.977570e-01 0.526 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.754004e-01 0.756 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.692174e-01 0.570 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 2.244208e-01 0.649 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.246442e-01 0.489 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.261851e-01 0.487 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.261851e-01 0.487 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.261851e-01 0.487 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.261851e-01 0.487 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.329086e-01 0.478 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.329086e-01 0.478 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.331597e-01 0.477 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.331597e-01 0.477 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.339799e-01 0.476 0 0
Generation of second messenger molecules R-HSA-202433 3.339799e-01 0.476 0 0
Interleukin-2 family signaling R-HSA-451927 3.339799e-01 0.476 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.364161e-01 0.473 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.364161e-01 0.473 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.364161e-01 0.473 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.364161e-01 0.473 0 0
SOS-mediated signalling R-HSA-112412 3.364161e-01 0.473 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.364161e-01 0.473 0 0
VLDL clearance R-HSA-8964046 3.364161e-01 0.473 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.364161e-01 0.473 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.364161e-01 0.473 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.372018e-01 0.472 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.382188e-01 0.471 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.392091e-01 0.470 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.396217e-01 0.469 0 0
Protein folding R-HSA-391251 3.408009e-01 0.467 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.452739e-01 0.462 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.470555e-01 0.460 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.512504e-01 0.454 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.512504e-01 0.454 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.512504e-01 0.454 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.512504e-01 0.454 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.512504e-01 0.454 0 0
Signal transduction by L1 R-HSA-445144 3.512504e-01 0.454 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.530734e-01 0.452 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.530734e-01 0.452 0 0
Gastrulation R-HSA-9758941 3.554160e-01 0.449 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.603866e-01 0.443 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.615939e-01 0.442 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.615939e-01 0.442 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.615939e-01 0.442 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.615939e-01 0.442 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.626156e-01 0.441 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.652541e-01 0.437 0 0
Removal of the Flap Intermediate R-HSA-69166 3.652541e-01 0.437 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.652541e-01 0.437 0 0
Regulation of KIT signaling R-HSA-1433559 3.652541e-01 0.437 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.670223e-01 0.435 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.670223e-01 0.435 0 0
Signal amplification R-HSA-392518 3.680381e-01 0.434 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.680381e-01 0.434 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.680381e-01 0.434 0 0
Lagging Strand Synthesis R-HSA-69186 3.780787e-01 0.422 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.780787e-01 0.422 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.780787e-01 0.422 0 0
MHC class II antigen presentation R-HSA-2132295 3.784459e-01 0.422 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.792337e-01 0.421 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.792337e-01 0.421 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.792337e-01 0.421 0 0
MET receptor recycling R-HSA-8875656 3.792337e-01 0.421 0 0
Adrenoceptors R-HSA-390696 3.792337e-01 0.421 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.792337e-01 0.421 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.805829e-01 0.420 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.805829e-01 0.420 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.805829e-01 0.420 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.805829e-01 0.420 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.805829e-01 0.420 0 0
Interleukin-33 signaling R-HSA-9014843 3.805829e-01 0.420 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.805829e-01 0.420 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.805829e-01 0.420 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.850056e-01 0.415 0 0
Signalling to ERKs R-HSA-187687 3.890690e-01 0.410 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.890690e-01 0.410 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.904333e-01 0.408 0 0
Protein methylation R-HSA-8876725 3.973257e-01 0.401 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.973257e-01 0.401 0 0
Formation of the anterior neural plate R-HSA-9823739 3.973257e-01 0.401 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.973257e-01 0.401 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.047930e-01 0.393 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.083704e-01 0.389 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.083704e-01 0.389 0 0
RUNX2 regulates bone development R-HSA-8941326 4.100871e-01 0.387 0 0
Regulation of beta-cell development R-HSA-186712 4.105101e-01 0.387 0 0
Signaling by FGFR4 R-HSA-5654743 4.107756e-01 0.386 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.107756e-01 0.386 0 0
Inositol phosphate metabolism R-HSA-1483249 4.161217e-01 0.381 0 0
Interleukin-21 signaling R-HSA-9020958 4.208428e-01 0.376 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.208428e-01 0.376 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.208428e-01 0.376 0 0
Unwinding of DNA R-HSA-176974 4.208428e-01 0.376 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.208428e-01 0.376 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.208428e-01 0.376 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.208428e-01 0.376 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.208428e-01 0.376 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.208428e-01 0.376 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 4.208428e-01 0.376 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.208428e-01 0.376 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.209282e-01 0.376 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.257196e-01 0.371 0 0
Selenoamino acid metabolism R-HSA-2408522 4.257960e-01 0.371 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.286953e-01 0.368 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 4.289399e-01 0.368 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.289399e-01 0.368 0 0
FGFR2 alternative splicing R-HSA-6803529 4.312801e-01 0.365 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 4.312801e-01 0.365 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.316099e-01 0.365 0 0
Activation of the pre-replicative complex R-HSA-68962 4.316099e-01 0.365 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.316099e-01 0.365 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.407415e-01 0.356 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.477045e-01 0.349 0 0
Signaling by FGFR3 R-HSA-5654741 4.491286e-01 0.348 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.504960e-01 0.346 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.504960e-01 0.346 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.504960e-01 0.346 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.504960e-01 0.346 0 0
Invadopodia formation R-HSA-8941237 4.504960e-01 0.346 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.504960e-01 0.346 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.504960e-01 0.346 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.504960e-01 0.346 0 0
MET activates STAT3 R-HSA-8875791 4.504960e-01 0.346 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 4.504960e-01 0.346 0 0
Histamine receptors R-HSA-390650 4.504960e-01 0.346 0 0
Potential therapeutics for SARS R-HSA-9679191 4.511317e-01 0.346 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.518551e-01 0.345 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.518551e-01 0.345 0 0
Translation R-HSA-72766 4.571907e-01 0.340 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.574377e-01 0.340 0 0
Formation of the ureteric bud R-HSA-9830674 4.574377e-01 0.340 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 4.599392e-01 0.337 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 4.599392e-01 0.337 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.599392e-01 0.337 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.599392e-01 0.337 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.599392e-01 0.337 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.599392e-01 0.337 0 0
Disorders of Developmental Biology R-HSA-9675151 4.599392e-01 0.337 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.609708e-01 0.336 0 0
2-LTR circle formation R-HSA-164843 4.609708e-01 0.336 0 0
Regulation of CDH11 function R-HSA-9762292 4.609708e-01 0.336 0 0
PI3K/AKT activation R-HSA-198203 4.609708e-01 0.336 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.609708e-01 0.336 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.609708e-01 0.336 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.642061e-01 0.333 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.681404e-01 0.330 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.720558e-01 0.326 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.757333e-01 0.323 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.771538e-01 0.321 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.774278e-01 0.321 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.789029e-01 0.320 0 0
Pyruvate metabolism R-HSA-70268 4.796686e-01 0.319 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.831743e-01 0.316 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.831743e-01 0.316 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.831743e-01 0.316 0 0
Interleukin-6 family signaling R-HSA-6783589 4.831743e-01 0.316 0 0
Signaling by FGFR2 R-HSA-5654738 4.839104e-01 0.315 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.893265e-01 0.310 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.901908e-01 0.310 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.901908e-01 0.310 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.901908e-01 0.310 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.929161e-01 0.307 0 0
Glycogen metabolism R-HSA-8982491 4.929161e-01 0.307 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 4.935366e-01 0.307 0 0
Adipogenesis R-HSA-9843745 4.938292e-01 0.306 0 0
Ion homeostasis R-HSA-5578775 4.992395e-01 0.302 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.994222e-01 0.302 0 0
Formation of the posterior neural plate R-HSA-9832991 4.994222e-01 0.302 0 0
Chylomicron assembly R-HSA-8963888 4.994222e-01 0.302 0 0
Interleukin-2 signaling R-HSA-9020558 4.994222e-01 0.302 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.994222e-01 0.302 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.998780e-01 0.301 0 0
G-protein beta:gamma signalling R-HSA-397795 4.998780e-01 0.301 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.998780e-01 0.301 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.998780e-01 0.301 0 0
Mitochondrial biogenesis R-HSA-1592230 5.019577e-01 0.299 0 0
Ca2+ pathway R-HSA-4086398 5.039992e-01 0.298 0 0
ER-Phagosome pathway R-HSA-1236974 5.078681e-01 0.294 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.084094e-01 0.294 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.084094e-01 0.294 0 0
Interleukin-7 signaling R-HSA-1266695 5.084094e-01 0.294 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.111623e-01 0.291 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.125216e-01 0.290 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.125216e-01 0.290 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.125216e-01 0.290 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.125216e-01 0.290 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.125216e-01 0.290 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.125216e-01 0.290 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.125216e-01 0.290 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.125216e-01 0.290 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.125216e-01 0.290 0 0
Sensory perception of sour taste R-HSA-9729555 5.125216e-01 0.290 0 0
NADE modulates death signalling R-HSA-205025 5.125216e-01 0.290 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.125216e-01 0.290 0 0
Interleukin-38 signaling R-HSA-9007892 5.125216e-01 0.290 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.130637e-01 0.290 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.162783e-01 0.287 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.195848e-01 0.284 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 5.195848e-01 0.284 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.195848e-01 0.284 0 0
Presynaptic function of Kainate receptors R-HSA-500657 5.195848e-01 0.284 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.195848e-01 0.284 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.219470e-01 0.282 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.219470e-01 0.282 0 0
Translation of Structural Proteins R-HSA-9683701 5.329008e-01 0.273 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.333642e-01 0.273 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.360642e-01 0.271 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.360642e-01 0.271 0 0
Integration of provirus R-HSA-162592 5.360642e-01 0.271 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.360642e-01 0.271 0 0
Specification of the neural plate border R-HSA-9834899 5.480327e-01 0.261 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.480327e-01 0.261 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.480327e-01 0.261 0 0
The NLRP3 inflammasome R-HSA-844456 5.480327e-01 0.261 0 0
Maturation of nucleoprotein R-HSA-9694631 5.480327e-01 0.261 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.571045e-01 0.254 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.571045e-01 0.254 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 5.571045e-01 0.254 0 0
Transcription of the HIV genome R-HSA-167172 5.577115e-01 0.254 0 0
Regulated Necrosis R-HSA-5218859 5.577115e-01 0.254 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.577115e-01 0.254 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 5.628974e-01 0.250 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.643905e-01 0.248 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.671675e-01 0.246 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.675493e-01 0.246 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.675493e-01 0.246 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.675493e-01 0.246 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.675493e-01 0.246 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.675493e-01 0.246 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 5.675493e-01 0.246 0 0
Activation of C3 and C5 R-HSA-174577 5.675493e-01 0.246 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.675493e-01 0.246 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.675493e-01 0.246 0 0
Interleukin-36 pathway R-HSA-9014826 5.675493e-01 0.246 0 0
Inositol transporters R-HSA-429593 5.675493e-01 0.246 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.675493e-01 0.246 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.675493e-01 0.246 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.678075e-01 0.246 0 0
MET activates RAS signaling R-HSA-8851805 5.708154e-01 0.244 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.708154e-01 0.244 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.708154e-01 0.244 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.708154e-01 0.244 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.708154e-01 0.244 0 0
Disorders of Nervous System Development R-HSA-9697154 5.708154e-01 0.244 0 0
Pervasive developmental disorders R-HSA-9005895 5.708154e-01 0.244 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.708154e-01 0.244 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.708154e-01 0.244 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.732260e-01 0.242 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.732477e-01 0.242 0 0
Creatine metabolism R-HSA-71288 5.754650e-01 0.240 0 0
Formation of definitive endoderm R-HSA-9823730 5.754650e-01 0.240 0 0
Protein hydroxylation R-HSA-9629569 5.754650e-01 0.240 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.754650e-01 0.240 0 0
ABC transporter disorders R-HSA-5619084 5.790200e-01 0.237 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.804541e-01 0.236 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.804541e-01 0.236 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.804541e-01 0.236 0 0
PLC beta mediated events R-HSA-112043 5.832474e-01 0.234 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.844245e-01 0.233 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.854026e-01 0.233 0 0
RNA Polymerase III Transcription R-HSA-74158 5.854026e-01 0.233 0 0
Calmodulin induced events R-HSA-111933 5.854026e-01 0.233 0 0
CaM pathway R-HSA-111997 5.854026e-01 0.233 0 0
Proteasome assembly R-HSA-9907900 5.901986e-01 0.229 0 0
PI Metabolism R-HSA-1483255 5.943090e-01 0.226 0 0
Post NMDA receptor activation events R-HSA-438064 5.980985e-01 0.223 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.992464e-01 0.222 0 0
Signaling by PDGF R-HSA-186797 5.992464e-01 0.222 0 0
ERK/MAPK targets R-HSA-198753 6.018296e-01 0.221 0 0
G-protein activation R-HSA-202040 6.018296e-01 0.221 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.030800e-01 0.220 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.035072e-01 0.219 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 6.036357e-01 0.219 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.036357e-01 0.219 0 0
Formation of axial mesoderm R-HSA-9796292 6.036357e-01 0.219 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.036357e-01 0.219 0 0
Maturation of nucleoprotein R-HSA-9683610 6.036357e-01 0.219 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.036357e-01 0.219 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.084619e-01 0.216 0 0
Signaling by NTRKs R-HSA-166520 6.087994e-01 0.216 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.163682e-01 0.210 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.163682e-01 0.210 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.163682e-01 0.210 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.163682e-01 0.210 0 0
Signaling by MAPK mutants R-HSA-9652817 6.163682e-01 0.210 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.163682e-01 0.210 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.163682e-01 0.210 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.163682e-01 0.210 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.163682e-01 0.210 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.163682e-01 0.210 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.163682e-01 0.210 0 0
Synthesis of PS R-HSA-1483101 6.163682e-01 0.210 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.163682e-01 0.210 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.163682e-01 0.210 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.163682e-01 0.210 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.163682e-01 0.210 0 0
Toll-like Receptor Cascades R-HSA-168898 6.180515e-01 0.209 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.250482e-01 0.204 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.250482e-01 0.204 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.270900e-01 0.203 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.270900e-01 0.203 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.280143e-01 0.202 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.281010e-01 0.202 0 0
Platelet degranulation R-HSA-114608 6.294909e-01 0.201 0 0
RSV-host interactions R-HSA-9833110 6.311736e-01 0.200 0 0
Interferon gamma signaling R-HSA-877300 6.324338e-01 0.199 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.345183e-01 0.198 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.345183e-01 0.198 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.345183e-01 0.198 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.345183e-01 0.198 0 0
HDL assembly R-HSA-8963896 6.345183e-01 0.198 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.345183e-01 0.198 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.345183e-01 0.198 0 0
Prolactin receptor signaling R-HSA-1170546 6.345183e-01 0.198 0 0
Malate-aspartate shuttle R-HSA-9856872 6.345183e-01 0.198 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.345183e-01 0.198 0 0
Neutrophil degranulation R-HSA-6798695 6.360949e-01 0.196 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.439918e-01 0.191 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.439918e-01 0.191 0 0
Signaling by FGFR1 R-HSA-5654736 6.441551e-01 0.191 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.441551e-01 0.191 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.486203e-01 0.188 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.486203e-01 0.188 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.512234e-01 0.186 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 6.512234e-01 0.186 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.512234e-01 0.186 0 0
Signaling by KIT in disease R-HSA-9669938 6.512234e-01 0.186 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.512234e-01 0.186 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.596785e-01 0.181 0 0
Signaling by LTK in cancer R-HSA-9842640 6.596785e-01 0.181 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.596785e-01 0.181 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.596785e-01 0.181 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.596785e-01 0.181 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.596785e-01 0.181 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.596785e-01 0.181 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.596785e-01 0.181 0 0
MET Receptor Activation R-HSA-6806942 6.596785e-01 0.181 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.596785e-01 0.181 0 0
CREB phosphorylation R-HSA-199920 6.596785e-01 0.181 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.596785e-01 0.181 0 0
Abacavir transmembrane transport R-HSA-2161517 6.596785e-01 0.181 0 0
NADPH regeneration R-HSA-389542 6.596785e-01 0.181 0 0
VLDL assembly R-HSA-8866423 6.596785e-01 0.181 0 0
Neurofascin interactions R-HSA-447043 6.596785e-01 0.181 0 0
HIV Transcription Elongation R-HSA-167169 6.623243e-01 0.179 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.623243e-01 0.179 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.623243e-01 0.179 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.623243e-01 0.179 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.634824e-01 0.178 0 0
Erythropoietin activates RAS R-HSA-9027284 6.634824e-01 0.178 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.634824e-01 0.178 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.634824e-01 0.178 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.634824e-01 0.178 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.634824e-01 0.178 0 0
DNA Damage Reversal R-HSA-73942 6.634824e-01 0.178 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.742189e-01 0.171 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.742189e-01 0.171 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.742189e-01 0.171 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.742189e-01 0.171 0 0
Syndecan interactions R-HSA-3000170 6.742189e-01 0.171 0 0
G-protein mediated events R-HSA-112040 6.742632e-01 0.171 0 0
Hedgehog 'off' state R-HSA-5610787 6.763544e-01 0.170 0 0
Gap junction trafficking and regulation R-HSA-157858 6.767610e-01 0.170 0 0
Stimuli-sensing channels R-HSA-2672351 6.775550e-01 0.169 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.775550e-01 0.169 0 0
Nuclear RNA decay R-HSA-9930044 6.858024e-01 0.164 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.858024e-01 0.164 0 0
Translation of Structural Proteins R-HSA-9694635 6.873776e-01 0.163 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.905674e-01 0.161 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.905674e-01 0.161 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.905674e-01 0.161 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.905674e-01 0.161 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.905674e-01 0.161 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.905674e-01 0.161 0 0
Differentiation of T cells R-HSA-9945266 6.905674e-01 0.161 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.960761e-01 0.157 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.960761e-01 0.157 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.971070e-01 0.157 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.971070e-01 0.157 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.981015e-01 0.156 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.981015e-01 0.156 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.981015e-01 0.156 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.981015e-01 0.156 0 0
PTK6 Expression R-HSA-8849473 6.981015e-01 0.156 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.981015e-01 0.156 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.981015e-01 0.156 0 0
LDL remodeling R-HSA-8964041 6.981015e-01 0.156 0 0
Netrin mediated repulsion signals R-HSA-418886 6.981015e-01 0.156 0 0
CHL1 interactions R-HSA-447041 6.981015e-01 0.156 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.981015e-01 0.156 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.016461e-01 0.154 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.041451e-01 0.152 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.044628e-01 0.152 0 0
Sensory processing of sound R-HSA-9659379 7.127459e-01 0.147 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.135426e-01 0.147 0 0
Ca-dependent events R-HSA-111996 7.135426e-01 0.147 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.158283e-01 0.145 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 7.158283e-01 0.145 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.158283e-01 0.145 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.158283e-01 0.145 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 7.158283e-01 0.145 0 0
Response to metal ions R-HSA-5660526 7.158283e-01 0.145 0 0
Long-term potentiation R-HSA-9620244 7.168034e-01 0.145 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.168034e-01 0.145 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.168034e-01 0.145 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.180443e-01 0.144 0 0
Calnexin/calreticulin cycle R-HSA-901042 7.223063e-01 0.141 0 0
RSK activation R-HSA-444257 7.321884e-01 0.135 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.321884e-01 0.135 0 0
Activation of RAS in B cells R-HSA-1169092 7.321884e-01 0.135 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.321884e-01 0.135 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.321884e-01 0.135 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 7.321884e-01 0.135 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.321884e-01 0.135 0 0
Fructose biosynthesis R-HSA-5652227 7.321884e-01 0.135 0 0
Co-stimulation by ICOS R-HSA-9927354 7.321884e-01 0.135 0 0
Interleukin-9 signaling R-HSA-8985947 7.321884e-01 0.135 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.321884e-01 0.135 0 0
Alpha-defensins R-HSA-1462054 7.321884e-01 0.135 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.321884e-01 0.135 0 0
Interleukin-23 signaling R-HSA-9020933 7.321884e-01 0.135 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.364169e-01 0.133 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.364169e-01 0.133 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.364169e-01 0.133 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.388351e-01 0.131 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.393319e-01 0.131 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.393319e-01 0.131 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.393319e-01 0.131 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.393319e-01 0.131 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.393319e-01 0.131 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.393319e-01 0.131 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.393319e-01 0.131 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.393319e-01 0.131 0 0
Gap junction trafficking R-HSA-190828 7.444921e-01 0.128 0 0
Signaling by FGFR R-HSA-190236 7.535073e-01 0.123 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.549388e-01 0.122 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.549388e-01 0.122 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.549388e-01 0.122 0 0
Signaling by Hedgehog R-HSA-5358351 7.563446e-01 0.121 0 0
Somitogenesis R-HSA-9824272 7.590109e-01 0.120 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.611527e-01 0.119 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 7.611527e-01 0.119 0 0
Platelet sensitization by LDL R-HSA-432142 7.611527e-01 0.119 0 0
Tie2 Signaling R-HSA-210993 7.611527e-01 0.119 0 0
Nephron development R-HSA-9831926 7.611527e-01 0.119 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.624285e-01 0.118 0 0
WNT mediated activation of DVL R-HSA-201688 7.624285e-01 0.118 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.624285e-01 0.118 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.624285e-01 0.118 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 7.624285e-01 0.118 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.624285e-01 0.118 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.624285e-01 0.118 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.624285e-01 0.118 0 0
Degradation of GABA R-HSA-916853 7.624285e-01 0.118 0 0
Interleukin-1 processing R-HSA-448706 7.624285e-01 0.118 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.624285e-01 0.118 0 0
IRE1alpha activates chaperones R-HSA-381070 7.664390e-01 0.116 0 0
Interferon alpha/beta signaling R-HSA-909733 7.686586e-01 0.114 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.705345e-01 0.113 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.709999e-01 0.113 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.723967e-01 0.112 0 0
Inflammasomes R-HSA-622312 7.723967e-01 0.112 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.723967e-01 0.112 0 0
Pyroptosis R-HSA-5620971 7.723967e-01 0.112 0 0
Iron uptake and transport R-HSA-917937 7.747955e-01 0.111 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.764238e-01 0.110 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.765145e-01 0.110 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.813711e-01 0.107 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.813711e-01 0.107 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.813711e-01 0.107 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.813711e-01 0.107 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.813711e-01 0.107 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.861684e-01 0.104 0 0
Signaling by Erythropoietin R-HSA-9006335 7.888222e-01 0.103 0 0
mRNA Capping R-HSA-72086 7.888222e-01 0.103 0 0
Platelet calcium homeostasis R-HSA-418360 7.888222e-01 0.103 0 0
Glucagon-type ligand receptors R-HSA-420092 7.888222e-01 0.103 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.892555e-01 0.103 0 0
DNA replication initiation R-HSA-68952 7.892555e-01 0.103 0 0
Binding and entry of HIV virion R-HSA-173107 7.892555e-01 0.103 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.892555e-01 0.103 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.892555e-01 0.103 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.892555e-01 0.103 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.892555e-01 0.103 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.892555e-01 0.103 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.892555e-01 0.103 0 0
Interleukin-27 signaling R-HSA-9020956 7.892555e-01 0.103 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.892555e-01 0.103 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.919352e-01 0.101 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.931056e-01 0.101 0 0
RAS processing R-HSA-9648002 7.995593e-01 0.097 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.000707e-01 0.097 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.000707e-01 0.097 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.000707e-01 0.097 0 0
Signaling by NODAL R-HSA-1181150 8.000707e-01 0.097 0 0
Pregnenolone biosynthesis R-HSA-196108 8.000707e-01 0.097 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.003583e-01 0.097 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.042503e-01 0.095 0 0
DAP12 signaling R-HSA-2424491 8.042503e-01 0.095 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.042503e-01 0.095 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.042503e-01 0.095 0 0
tRNA processing R-HSA-72306 8.066831e-01 0.093 0 0
Opioid Signalling R-HSA-111885 8.094433e-01 0.092 0 0
Extension of Telomeres R-HSA-180786 8.113302e-01 0.091 0 0
Peroxisomal protein import R-HSA-9033241 8.113302e-01 0.091 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.127212e-01 0.090 0 0
Diseases of Immune System R-HSA-5260271 8.127212e-01 0.090 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.127212e-01 0.090 0 0
Signaling by APC mutants R-HSA-4839744 8.130546e-01 0.090 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 8.130546e-01 0.090 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 8.130546e-01 0.090 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 8.130546e-01 0.090 0 0
vRNP Assembly R-HSA-192905 8.130546e-01 0.090 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.130546e-01 0.090 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.130546e-01 0.090 0 0
LGI-ADAM interactions R-HSA-5682910 8.130546e-01 0.090 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.130546e-01 0.090 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.130546e-01 0.090 0 0
Suppression of apoptosis R-HSA-9635465 8.130546e-01 0.090 0 0
Transport of RCbl within the body R-HSA-9758890 8.130546e-01 0.090 0 0
Prostanoid ligand receptors R-HSA-391908 8.130546e-01 0.090 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.130546e-01 0.090 0 0
Integration of energy metabolism R-HSA-163685 8.133013e-01 0.090 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 8.173365e-01 0.088 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.173365e-01 0.088 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.173365e-01 0.088 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.187185e-01 0.087 0 0
Immune System R-HSA-168256 8.304865e-01 0.081 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.322660e-01 0.080 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.332539e-01 0.079 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.341673e-01 0.079 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.341673e-01 0.079 0 0
ERKs are inactivated R-HSA-202670 8.341673e-01 0.079 0 0
Signaling by GSK3beta mutants R-HSA-5339716 8.341673e-01 0.079 0 0
Signaling by AXIN mutants R-HSA-4839735 8.341673e-01 0.079 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.341673e-01 0.079 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.341673e-01 0.079 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.341673e-01 0.079 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.341673e-01 0.079 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.341673e-01 0.079 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.341673e-01 0.079 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.341673e-01 0.079 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.369181e-01 0.077 0 0
HIV Transcription Initiation R-HSA-167161 8.369181e-01 0.077 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.369181e-01 0.077 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.416125e-01 0.075 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.416699e-01 0.075 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.418134e-01 0.075 0 0
Neddylation R-HSA-8951664 8.428153e-01 0.074 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.436214e-01 0.074 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.472239e-01 0.072 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.479072e-01 0.072 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.479072e-01 0.072 0 0
LDL clearance R-HSA-8964038 8.479072e-01 0.072 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.510424e-01 0.070 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.528967e-01 0.069 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.528967e-01 0.069 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.528967e-01 0.069 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.528967e-01 0.069 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.528967e-01 0.069 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.528967e-01 0.069 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.528967e-01 0.069 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.528967e-01 0.069 0 0
Interleukin-35 Signalling R-HSA-8984722 8.528967e-01 0.069 0 0
Signaling by LTK R-HSA-9842663 8.528967e-01 0.069 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.528967e-01 0.069 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.528967e-01 0.069 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.528967e-01 0.069 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.528967e-01 0.069 0 0
Interleukin-15 signaling R-HSA-8983432 8.528967e-01 0.069 0 0
OAS antiviral response R-HSA-8983711 8.528967e-01 0.069 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.534384e-01 0.069 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.567615e-01 0.067 0 0
Infectious disease R-HSA-5663205 8.579570e-01 0.067 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.584399e-01 0.066 0 0
Signaling by FGFR in disease R-HSA-1226099 8.586045e-01 0.066 0 0
Ion transport by P-type ATPases R-HSA-936837 8.598260e-01 0.066 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.613787e-01 0.065 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.613787e-01 0.065 0 0
Carnitine shuttle R-HSA-200425 8.613787e-01 0.065 0 0
Interleukin-20 family signaling R-HSA-8854691 8.613787e-01 0.065 0 0
Hyaluronan metabolism R-HSA-2142845 8.677919e-01 0.062 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.677919e-01 0.062 0 0
Amine ligand-binding receptors R-HSA-375280 8.682610e-01 0.061 0 0
Cilium Assembly R-HSA-5617833 8.690165e-01 0.061 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.695118e-01 0.061 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.695118e-01 0.061 0 0
Chylomicron remodeling R-HSA-8963901 8.695118e-01 0.061 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.695118e-01 0.061 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.695118e-01 0.061 0 0
G alpha (z) signalling events R-HSA-418597 8.715339e-01 0.060 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.737485e-01 0.059 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.737485e-01 0.059 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.737485e-01 0.059 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.737485e-01 0.059 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.774900e-01 0.057 0 0
Kidney development R-HSA-9830369 8.836393e-01 0.054 0 0
Physiological factors R-HSA-5578768 8.842511e-01 0.053 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.842511e-01 0.053 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.842511e-01 0.053 0 0
Zinc transporters R-HSA-435354 8.842511e-01 0.053 0 0
G protein gated Potassium channels R-HSA-1296059 8.850935e-01 0.053 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.850935e-01 0.053 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.850935e-01 0.053 0 0
Tight junction interactions R-HSA-420029 8.850935e-01 0.053 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.850935e-01 0.053 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.850935e-01 0.053 0 0
Hyaluronan degradation R-HSA-2160916 8.850935e-01 0.053 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.850935e-01 0.053 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.865363e-01 0.052 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.951066e-01 0.048 0 0
MET activates PTK2 signaling R-HSA-8874081 8.954873e-01 0.048 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.954873e-01 0.048 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.954873e-01 0.048 0 0
TRP channels R-HSA-3295583 8.954873e-01 0.048 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.954873e-01 0.048 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.973262e-01 0.047 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.973262e-01 0.047 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.973262e-01 0.047 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.973262e-01 0.047 0 0
Protein lipoylation R-HSA-9857492 8.973262e-01 0.047 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.973262e-01 0.047 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.973262e-01 0.047 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.973262e-01 0.047 0 0
Other semaphorin interactions R-HSA-416700 8.973262e-01 0.047 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.973262e-01 0.047 0 0
Co-stimulation by CD28 R-HSA-389356 9.018868e-01 0.045 0 0
NGF-stimulated transcription R-HSA-9031628 9.018868e-01 0.045 0 0
Gluconeogenesis R-HSA-70263 9.018868e-01 0.045 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.032962e-01 0.044 0 0
Cristae formation R-HSA-8949613 9.050000e-01 0.043 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 9.050000e-01 0.043 0 0
Signaling by BMP R-HSA-201451 9.050000e-01 0.043 0 0
Insulin processing R-HSA-264876 9.050000e-01 0.043 0 0
Ion channel transport R-HSA-983712 9.063276e-01 0.043 0 0
Metabolism of polyamines R-HSA-351202 9.086584e-01 0.042 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.089251e-01 0.041 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.089251e-01 0.041 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.089251e-01 0.041 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.089251e-01 0.041 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.089251e-01 0.041 0 0
Activation of SMO R-HSA-5635838 9.089251e-01 0.041 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.089251e-01 0.041 0 0
Atorvastatin ADME R-HSA-9754706 9.089251e-01 0.041 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.090083e-01 0.041 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.099929e-01 0.041 0 0
Signaling by ALK R-HSA-201556 9.123971e-01 0.040 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.123971e-01 0.040 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.128328e-01 0.040 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.148410e-01 0.039 0 0
PI3K Cascade R-HSA-109704 9.156666e-01 0.038 0 0
Synthesis of PG R-HSA-1483148 9.192143e-01 0.037 0 0
Galactose catabolism R-HSA-70370 9.192143e-01 0.037 0 0
Coenzyme A biosynthesis R-HSA-196783 9.192143e-01 0.037 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.192143e-01 0.037 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.246798e-01 0.034 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.283416e-01 0.032 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.283416e-01 0.032 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.310101e-01 0.031 0 0
IGF1R signaling cascade R-HSA-2428924 9.312306e-01 0.031 0 0
Insulin receptor signalling cascade R-HSA-74751 9.312306e-01 0.031 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.321008e-01 0.031 0 0
Trafficking of AMPA receptors R-HSA-399719 9.355114e-01 0.029 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.360323e-01 0.029 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.364381e-01 0.029 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.364381e-01 0.029 0 0
PKA activation in glucagon signalling R-HSA-164378 9.364381e-01 0.029 0 0
PKA activation R-HSA-163615 9.364381e-01 0.029 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.364381e-01 0.029 0 0
Activation of GABAB receptors R-HSA-991365 9.377031e-01 0.028 0 0
GABA B receptor activation R-HSA-977444 9.377031e-01 0.028 0 0
Signaling by WNT in cancer R-HSA-4791275 9.415395e-01 0.026 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.415395e-01 0.026 0 0
Paracetamol ADME R-HSA-9753281 9.428399e-01 0.026 0 0
Hemostasis R-HSA-109582 9.429115e-01 0.026 0 0
Pyrimidine biosynthesis R-HSA-500753 9.436203e-01 0.025 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.436203e-01 0.025 0 0
Other interleukin signaling R-HSA-449836 9.436203e-01 0.025 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.436203e-01 0.025 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.436203e-01 0.025 0 0
HDL remodeling R-HSA-8964058 9.436203e-01 0.025 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.436203e-01 0.025 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.470293e-01 0.024 0 0
Recycling of bile acids and salts R-HSA-159418 9.470293e-01 0.024 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.475658e-01 0.023 0 0
DAP12 interactions R-HSA-2172127 9.476461e-01 0.023 0 0
Regulation of insulin secretion R-HSA-422356 9.479390e-01 0.023 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.499912e-01 0.022 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.499912e-01 0.022 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.499912e-01 0.022 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.499912e-01 0.022 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.499912e-01 0.022 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.511036e-01 0.022 0 0
IRS-mediated signalling R-HSA-112399 9.512661e-01 0.022 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.520253e-01 0.021 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.520439e-01 0.021 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.520439e-01 0.021 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.556426e-01 0.020 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.556426e-01 0.020 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.556426e-01 0.020 0 0
Basigin interactions R-HSA-210991 9.556426e-01 0.020 0 0
SLC transporter disorders R-HSA-5619102 9.560930e-01 0.019 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.560947e-01 0.019 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.560947e-01 0.019 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.565690e-01 0.019 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.585363e-01 0.018 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.606556e-01 0.017 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.606556e-01 0.017 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.606556e-01 0.017 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.606556e-01 0.017 0 0
GABA receptor activation R-HSA-977443 9.617824e-01 0.017 0 0
GPER1 signaling R-HSA-9634597 9.632527e-01 0.016 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.632527e-01 0.016 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.644501e-01 0.016 0 0
Glycosphingolipid transport R-HSA-9845576 9.644501e-01 0.016 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.644501e-01 0.016 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.648139e-01 0.016 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.651024e-01 0.015 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.651024e-01 0.015 0 0
Fructose metabolism R-HSA-5652084 9.651024e-01 0.015 0 0
Ethanol oxidation R-HSA-71384 9.651024e-01 0.015 0 0
Cellular hexose transport R-HSA-189200 9.651024e-01 0.015 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.668657e-01 0.015 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.674740e-01 0.014 0 0
Mitochondrial protein import R-HSA-1268020 9.675788e-01 0.014 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.678559e-01 0.014 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.690468e-01 0.014 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.690468e-01 0.014 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.690468e-01 0.014 0 0
Complex III assembly R-HSA-9865881 9.725456e-01 0.012 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.725456e-01 0.012 0 0
Pentose phosphate pathway R-HSA-71336 9.737488e-01 0.012 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.756490e-01 0.011 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.756490e-01 0.011 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.756490e-01 0.011 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.756490e-01 0.011 0 0
Laminin interactions R-HSA-3000157 9.756490e-01 0.011 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.756490e-01 0.011 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.767942e-01 0.010 0 0
Urea cycle R-HSA-70635 9.784019e-01 0.009 0 0
Sphingolipid catabolism R-HSA-9845614 9.784019e-01 0.009 0 0
Abacavir ADME R-HSA-2161522 9.784019e-01 0.009 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.784019e-01 0.009 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.784019e-01 0.009 0 0
Maturation of spike protein R-HSA-9694548 9.785910e-01 0.009 0 0
Nicotinate metabolism R-HSA-196807 9.786783e-01 0.009 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.801118e-01 0.009 0 0
Parasite infection R-HSA-9664407 9.801118e-01 0.009 0 0
Leishmania phagocytosis R-HSA-9664417 9.801118e-01 0.009 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.806756e-01 0.008 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.808436e-01 0.008 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.808436e-01 0.008 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.808436e-01 0.008 0 0
Cardiac conduction R-HSA-5576891 9.813343e-01 0.008 0 0
Telomere Extension By Telomerase R-HSA-171319 9.830094e-01 0.007 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.830094e-01 0.007 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.830094e-01 0.007 0 0
Prednisone ADME R-HSA-9757110 9.830094e-01 0.007 0 0
Pyrimidine salvage R-HSA-73614 9.830094e-01 0.007 0 0
Dectin-2 family R-HSA-5621480 9.838565e-01 0.007 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.849305e-01 0.007 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.849305e-01 0.007 0 0
PPARA activates gene expression R-HSA-1989781 9.854466e-01 0.006 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.858145e-01 0.006 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.866345e-01 0.006 0 0
Neurotransmitter clearance R-HSA-112311 9.866345e-01 0.006 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.866345e-01 0.006 0 0
Leishmania infection R-HSA-9658195 9.868283e-01 0.006 0 0
Parasitic Infection Pathways R-HSA-9824443 9.868283e-01 0.006 0 0
Platelet homeostasis R-HSA-418346 9.870855e-01 0.006 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.871425e-01 0.006 0 0
Cargo concentration in the ER R-HSA-5694530 9.881459e-01 0.005 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.881459e-01 0.005 0 0
Aquaporin-mediated transport R-HSA-445717 9.889106e-01 0.005 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.891912e-01 0.005 0 0
Disease R-HSA-1643685 9.894783e-01 0.005 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.906754e-01 0.004 0 0
Cardiogenesis R-HSA-9733709 9.906754e-01 0.004 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.915730e-01 0.004 0 0
Neurotransmitter release cycle R-HSA-112310 9.917217e-01 0.004 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.917301e-01 0.004 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.917301e-01 0.004 0 0
Heme degradation R-HSA-189483 9.917301e-01 0.004 0 0
Integrin cell surface interactions R-HSA-216083 9.918097e-01 0.004 0 0
Protein localization R-HSA-9609507 9.918922e-01 0.004 0 0
Post-translational protein modification R-HSA-597592 9.919395e-01 0.004 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.924123e-01 0.003 0 0
Gap junction assembly R-HSA-190861 9.926654e-01 0.003 0 0
eNOS activation R-HSA-203615 9.926654e-01 0.003 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.926654e-01 0.003 0 0
RA biosynthesis pathway R-HSA-5365859 9.926654e-01 0.003 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.926654e-01 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.934951e-01 0.003 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.934951e-01 0.003 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.934951e-01 0.003 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.934951e-01 0.003 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.934951e-01 0.003 0 0
Signaling by Insulin receptor R-HSA-74752 9.935699e-01 0.003 0 0
G alpha (q) signalling events R-HSA-416476 9.936235e-01 0.003 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.942078e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.942309e-01 0.003 0 0
Triglyceride catabolism R-HSA-163560 9.942309e-01 0.003 0 0
Nucleotide biosynthesis R-HSA-8956320 9.944687e-01 0.002 0 0
Mitochondrial protein degradation R-HSA-9837999 9.945753e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.945753e-01 0.002 0 0
Voltage gated Potassium channels R-HSA-1296072 9.948836e-01 0.002 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.948836e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.948836e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.953240e-01 0.002 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.954624e-01 0.002 0 0
Elastic fibre formation R-HSA-1566948 9.954624e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.954624e-01 0.002 0 0
Purine salvage R-HSA-74217 9.954624e-01 0.002 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.957579e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.959758e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.963667e-01 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.964291e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.964311e-01 0.002 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.964311e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.964311e-01 0.002 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.964311e-01 0.002 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.965014e-01 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.967661e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.968349e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.971338e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.971931e-01 0.001 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.971931e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.972463e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.973738e-01 0.001 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.975108e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.975108e-01 0.001 0 0
Neuronal System R-HSA-112316 9.975368e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.976407e-01 0.001 0 0
Defensins R-HSA-1461973 9.977925e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.978694e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.980121e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.980121e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.980423e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.980423e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.982911e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.983299e-01 0.001 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.984604e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.986347e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.987641e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.987641e-01 0.001 0 0
Intraflagellar transport R-HSA-5620924 9.987893e-01 0.001 0 0
Metal ion SLC transporters R-HSA-425410 9.987893e-01 0.001 0 0
Mitochondrial translation elongation R-HSA-5389840 9.988123e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.988123e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.988909e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.988909e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.990175e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.990479e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.990479e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.990683e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.991073e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.991557e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.991557e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.991557e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.991993e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.992050e-01 0.000 0 0
Transmission across Chemical Synapses R-HSA-112315 9.992435e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.992819e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.993909e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.994237e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.995895e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.996185e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.996274e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.996689e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.996772e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.996772e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.996907e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.997138e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.997138e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.997138e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.997462e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.997462e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.998005e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.998231e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.998767e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.998838e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.998870e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999238e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.999238e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999238e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999401e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999469e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999473e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999574e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999636e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999672e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999709e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999731e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999738e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999738e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999771e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999795e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999841e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999897e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999897e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999921e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999940e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999958e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999963e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999964e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999984e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999988e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999989e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999989e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999991e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999995e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999996e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999998e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999998e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999998e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999998e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways