CAMKK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0MZ66 T455 Sugiyama SHTN1 KIAA1598 KPESSKGCEsAVDELKGILGtLNKSTSSRsLKsLDPENsEt
A0MZ66 T501 Sugiyama SHTN1 KIAA1598 LRRRKVtAEADsssPtGILAtsEsKsMPVLGsVssVTKTAL
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
O00429 S44 Sugiyama DNM1L DLP1 DRP1 QLPQIVVVGTQSSGKSsVLEsLVGRDLLPRGTGIVTRRPLI
O14530 T21 Sugiyama TXNDC9 APACD MEADASVDMFSKVLEHQLLQtTKLVEEHLDSEIQKLDQMDE
O14910 S135 Sugiyama LIN7A MALS1 VELI1 DEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLKRGDQL
O43390 T134 Sugiyama HNRNPR HNRPR KVQESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O43399 T146 Sugiyama TPD52L2 yKKTQETLsQAGQKtsAALstVGsAIsRKLGDMRNsAtFKs
O43423 T101 Sugiyama ANP32CP PP32R1 EKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCEV
O43707 T443 Sugiyama ACTN4 sIHEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDL
O43707 T445 Sugiyama ACTN4 HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O43852 T196 Sugiyama CALU FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O43852 T89 Sugiyama CALU sKERLGKIVSKIDGDKDGFVtVDELKDWIKFAQKRWIyEDV
O60271 T191 Sugiyama SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 MEHLERTKLHQLsGsDQLEstAHsRIRKERPIsLGIFPLPA
O60506 T131 Sugiyama SYNCRIP HNRPQ NSAP1 KVADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O60664 S175 Sugiyama PLIN3 M6PRBP1 TIP47 RGAVQSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGK
O60664 S179 Sugiyama PLIN3 M6PRBP1 TIP47 QSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGKsEEW
O75116 T573 Sugiyama ROCK2 KIAA0619 STEKVNQLQRQLDEtNALLRtESDTAARLRKTQAESSKQIQ
O75390 S83 Sugiyama CS ITVDMMYGGMRGMKGLVyEtsVLDPDEGIRFRGFsIPECQK
O75821 T206 Sugiyama EIF3G EIF3S4 LGLstGEKEKLPGELEPVQAtQNKtGKYVPPsLRDGAsRRG
O75914 T119 Sugiyama PAK3 OPHN3 QMCPGKLPEGIPEQWARLLQtsNItKLEQKKNPQAVLDVLK
O95155 T95 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 RsQssEGVssLsssPsNsLEtQsQsLsRsQsMDIDGVSCEK
O95626 T105 Sugiyama ANP32D PP32R2 EKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCEV
O95757 S599 Sugiyama HSPA4L APG1 HSPH3 OSP94 sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
O95816 S31 Sugiyama BAG2 NEGRFCRsssMADRsSRLLEsLDQLELRVEALREAATAVEQ
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00338 T95 Sugiyama LDHA PIG19 PKIVSGKDyNVTANsKLVIItAGARQQEGEsRLNLVQRNVN
P00558 S393 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDA
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P04040 T29 Sugiyama CAT SDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRGP
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075 T65 Sugiyama ALDOA ALDA QsIGtENtEENRRFyRQLLLtADDRVNPCIGGVILFHETLY
P04083 T172 Sugiyama ANXA1 ANX1 LPC1 INRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDF
P04083 T223 Sugiyama ANXA1 ANX1 LPC1 ARALyEAGERRKGtDVNVFNtILttRSyPQLRRVFQKYTKY
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T246 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792 S176 Sugiyama HSPB1 HSP27 HSP28 sLsPEGtLTVEAPMPKLAtQsNEItIPVtFEsRAQLGGPEA
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05198 T281 Sugiyama EIF2S1 EIF2A KIEEKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVD
P05387 S29 Sugiyama RPLP2 D11S2243E RPP2 LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P05787 T153 Sugiyama KRT8 CYK8 RSNMDNMFESYINNLRRQLEtLGQEKLKLEAELGNMQGLVE
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P06744 T248 Sugiyama GPI WFLQAAKDPSAVAKHFVALstNttKVKEFGIDPQNMFEFWD
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 S393 Sugiyama PGK2 PGKB GGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEA
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07237 T453 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB EAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKFLESG
P07437 S75 Sugiyama TUBB TUBB5 OK/SW-cl.56 tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07437 T72 Sugiyama TUBB TUBB5 OK/SW-cl.56 NEAtGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
P07711 T332 Sugiyama CTSL CTSL1 VKMAKDRRNHCGIAsAAsyPtV___________________
P07814 T1506 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 LCELQPGAKCVCGKNPAKyytLFGRsy______________
P07814 T746 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 NETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVRE
P07900 S165 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S641 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD
P07900 T109 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LtIVDtGIGMTKADLINNLGtIAKSGtKAFMEALQAGADIS
P07900 T645 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKDLVIL
P08195 S403 Sugiyama SLC3A2 MDU1 SDLQQILSLLESNKDLLLtssyLsDsGstGEHtKSLVTQYL
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195 T599 Sugiyama SLC3A2 MDU1 QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238 S160 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S535 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB EPIDEyCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEE
P08238 T104 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LtLVDtGIGMtKADLINNLGtIAKSGtKAFMEALQAGADIS
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238 T637 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MGyMMAKKHLEINPDHPIVEtLRQKAEADKNDKAVKDLVVL
P08238 T85 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238 T89 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSG
P0DPH7 T51 Sugiyama TUBA3C TUBA2 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P10809 S453 Sugiyama HSPD1 HSP60 EEGIVLGGGCALLRCIPALDsLtPANEDQKIGIEIIKRTLK
P10809 T117 Sugiyama HSPD1 HSP60 LVQDVANNtNEEAGDGtttAtVLARSIAKEGFEKISKGANP
P10809 T231 Sugiyama HSPD1 HSP60 LEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLsEKKI
P11047 T856 Sugiyama LAMC1 LAMB2 PNAVGNCNRLTGECLKCIyNtAGFyCDRCKDGFFGNPLAPN
P11142 S544 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KYKAEDEKQRDKVssKNsLEsyAFNMKATVEDEKLQGKIND
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P12277 S164 Sugiyama CKB CKBB PHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAEQ
P13489 S178 Sugiyama RNH1 PRI RNH SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP
P13639 S732 Sugiyama EEF2 EF2 DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13667 T238 Sugiyama PDIA4 ERP70 ERP72 KAAKELSKRSPPIPLAKVDAtAETDLAKRFDVsGyPTLKIF
P13667 T380 Sugiyama PDIA4 ERP70 ERP72 PEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGHR
P14314 T492 Sugiyama PRKCSH G19P1 WQGPNRstTVRLLCGKEtMVtStTEPSRCEYLMELMTPAAC
P14550 T78 Sugiyama AKR1A1 ALDR1 ALR EALKEDVGPGKAVPREELFVtSKLWNTKHHPEDVEPALRKT
P14618 T195 Sugiyama PKM OIP3 PK2 PK3 PKM2 yVDDGLISLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAA
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S680 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 RIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLIRDMLRR
P14649 S87 Sugiyama MYL6B MLC1SA EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15880 S281 Sugiyama RPS2 RPS4 FtKsPyQEFtDHLVKtHtRVsVQRtQAPAVATt________
P15880 T285 Sugiyama RPS2 RPS4 PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P15880 T293 Sugiyama RPS2 RPS4 LVKtHtRVsVQRtQAPAVATt____________________
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17980 T163 Sugiyama PSMC3 TBP1 EKLKPGDLVGVNKDSyLILEtLPtEyDsRVKAMEVDERPtE
P18206 S820 Sugiyama VCL DAKAVAGNIsDPGLQKsFLDsGyRILGAVAKVREAFQPQEP
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18669 T146 Sugiyama PGAM1 PGAMA CDABP0006 MEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIARALPF
P20618 S157 Sugiyama PSMB1 PSC5 IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P23284 T81 Sugiyama PPIB CYPB IFGLFGKTVPKTVDNFVALAtGEKGFGYKNSKFHRVIKDFM
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23921 T555 Sugiyama RRM1 RR1 IyyGALEASCDLAKEQGPyEtyEGsPVsKGILQYDMWNVTP
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26639 T250 Sugiyama TARS1 TARS FKYNKFKCRILNEKVNtPtttVyRCGPLIDLCRGPHVRHTG
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P29401 T444 Sugiyama TKT DGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAANT
P29692 S60 Sugiyama EEF1D EF1D ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P30050 T135 Sugiyama RPL12 QMRHRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDI
P30086 T65 Sugiyama PEBP1 PBP PEBP QVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREWH
P31749 T308 SIGNOR AKT1 PKB RAC IKITDFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGR
P31946 T228 Sugiyama YWHAB LNEEsyKDstLIMQLLRDNLtLWtSENQGDEGDAGEGEN__
P31947 T228 Sugiyama SFN HME1 LsEDsyKDstLIMQLLRDNLtLWTADNAGEEGGEAPQEPQs
P31948 T243 Sugiyama STIP1 KQALKEKELGNDAYKKKDFDtALKHYDKAKELDPtNMtyIT
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33176 T182 Sugiyama KIF5B KNS KNS1 VPYVKGCTERFVCsPDEVMDtIDEGKSNRHVAVTNMNEHSS
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35613 S279 Sugiyama BSG UNQ6505/PRO21383 TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 T190 Sugiyama TAGLN2 KIAA0120 CDABP0035 GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P38117 T172 Sugiyama ETFB FP585 QVTLEGDKLKVEREIDGGLEtLRLKLPAVVTADLRLNEPRy
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 T86 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38646 T94 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39687 T105 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 EKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCEV
P40227 S49 Sugiyama CCT6A CCT6 CCTZ GLQDVLRTNLGPKGTMKMLVsGAGDIKLTKDGNVLLHEMQI
P41236 T55 Sugiyama PPP1R2 IPP2 NVDEELSKKsQKWDEMNILAtyHPADKDyGLMKIDEPstPY
P43490 T179 Sugiyama NAMPT PBEF PBEF1 ITVATNSREQKKILAKyLLEtsGNLDGLEyKLHDFGyRGVS
P46778 T29 Sugiyama RPL21 RGTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQ
P46937 T379 Sugiyama YAP1 YAP65 GGtQNPVssPGMsQELRTMttNssDPFLNsGtyHsRDEstD
P48444 T329 Sugiyama ARCN1 COPD KYGRIRLHVENEDKKGVQLQtHPNVDKKLFTAEsLIGLKNP
P48643 T269 Sugiyama CCT5 CCTE KIAA0098 AILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMI
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P50395 T205 Sugiyama GDI2 RABGDIB TGHALALYRtDDyLDQPCyEtINRIKLYsEsLARYGKsPYL
P50395 T412 Sugiyama GDI2 RABGDIB LGtEsQIFIsRTyDAttHFEttCDDIKNIYKRMtGsEFDFE
P50990 T286 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 MNFsKGEENLMDAQVKAIADtGANVVVtGGKVADMALHYAN
P50990 T374 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 EVGDTQVVVFKHEKEDGAIstIVLRGstDNLMDDIERAVDD
P50991 T50 Sugiyama CCT4 CCTD SRB PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P53999 S12 Sugiyama SUB1 PC4 RPO2TC1 _________MPKSKELVsssssGsDsDsEVDKKLKRKKQVA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P55060 S342 Sugiyama CSE1L CAS XPO2 ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174 T90 Sugiyama TPI1 TPI VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60660 S30 Sugiyama MYL6 AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK
P60709 S300 Sugiyama ACTB NSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItAL
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T106 Sugiyama ACTB WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709 T202 Sugiyama ACTB GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709 T297 Sugiyama ACTB TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P60709 Y294 Sugiyama ACTB IHETTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQ
P61163 T101 Sugiyama ACTR1A CTRN1 KDWNDMERIWQYVYSKDQLQtFSEEHPVLLtEAPLNPRKNR
P61163 T111 Sugiyama ACTR1A CTRN1 QYVYSKDQLQtFSEEHPVLLtEAPLNPRKNRERAAEVFFET
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61978 Y72 Sugiyama HNRNPK HNRPK KNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISA
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 T229 Sugiyama YWHAE LsEEsyKDstLIMQLLRDNLtLWtsDMQGDGEEQNKEALQD
P62266 T34 Sugiyama RPS23 RSHRRDQKWHDKQYKKAHLGtALKANPFGGAsHAKGIVLEK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62753 T128 Sugiyama RPS6 OK/SW-cl.2 VLNLVIVKKGEKDIPGLtDttVPRRLGPKRASRIRKLFNLs
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T232 Sugiyama YWHAZ KDstLIMQLLRDNLtLWtsDtQGDEAEAGEGGEN_______
P63261 S300 Sugiyama ACTG1 ACTG NSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItAL
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T106 Sugiyama ACTG1 ACTG WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261 T202 Sugiyama ACTG1 ACTG GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261 T297 Sugiyama ACTG1 ACTG TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P63261 Y294 Sugiyama ACTG1 ACTG IHETTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQ
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P67936 T237 Sugiyama TPM4 IDDLEEKLAQAKEENVGLHQtLDQtLNELNCI_________
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68363 T51 Sugiyama TUBA1B QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P78371 S144 Sugiyama CCT2 99D8.1 CCTB QTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIAG
P78371 T64 Sugiyama CCT2 99D8.1 CCTB GPKGMDKILLsSGRDAsLMVtNDGAtILKNIGVDNPAAKVL
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q00839 T530 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 KTTWVTKHAAENPGKyNILGtNtIMDKMMVAGFKKQMADtG
Q00839 T532 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 TWVTKHAAENPGKyNILGtNtIMDKMMVAGFKKQMADtGKL
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01518 T165 Sugiyama CAP1 CAP AMAPKPGPYVKEMNDAAMFytNRVLKEYKDVDKKHVDWVKA
Q01814 S1242 Sugiyama ATP2B2 PMCA2 DtsKSATSSsPGsPIHSLEtsL___________________
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q12792 S143 Sugiyama TWF1 PTK9 GTVKEDVSLHGYKKyLLsQssPAPLtAAEEELRQIKINEVQ
Q13131 T183 SIGNOR|EPSD|PSP PRKAA1 AMPK1 NAKIADFGLsNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
Q13136 T572 Sugiyama PPFIA1 LIP1 LRRPQKGRLAALRDEPSKVQtLNEQDWERAQQASVLANVAQ
Q13153 T109 Sugiyama PAK1 FDAVTGEFTGMPEQWARLLQtsNITKsEQKKNPQAVLDVLE
Q13177 T108 Sugiyama PAK2 FDAVTGEFTGMPEQWARLLQtsNItKLEQKKNPQAVLDVLK
Q13283 T241 Sugiyama G3BP1 G3BP ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q13509 S75 Sugiyama TUBB3 TUBB4 SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13509 T72 Sugiyama TUBB3 TUBB4 NEASSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIF
Q13561 T315 Sugiyama DCTN2 DCTN50 KHKASVEDADTQSKVHQLyEtIQRWsPIASTLPELVQRLVT
Q13885 S75 Sugiyama TUBB2A TUBB2 AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q13885 T72 Sugiyama TUBB2A TUBB2 NEAAGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
Q14012 T177 GPS6|SIGNOR|EPSD|PSP CAMK1 KIMISDFGLSKMEDPGSVLstACGTPGYVAPEVLAQKPYSK
Q14257 S298 Sugiyama RCN2 ERC55 NGDKKLsEEEILENPDLFLtsEAtDyGRQLHDDyFyHDEL_
Q14444 T303 Sugiyama CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV
Q14568 S165 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568 T109 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LTIVDTGIGMTKADLINNLGtIAKSGtKAFMEALQAGADIS
Q14677 T270 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 FKDEEETVTTKHIHItQATEttttRHKRTANPsKtIDLGAA
Q14980 T1166 Sugiyama NUMA1 NMP22 NUMA LERsLEAERASRAERDsALEtLQGQLEEKAQELGHsQsALA
Q15084 S230 Sugiyama PDIA6 ERP5 P5 TXNDC7 QTKGKVKLAAVDAtVNQVLAsRYGIRGFPtIKIFQKGEsPV
Q15084 T166 Sugiyama PDIA6 ERP5 P5 TXNDC7 YSSGKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFY
Q15084 T223 Sugiyama PDIA6 ERP5 P5 TXNDC7 AAsEVKEQTKGKVKLAAVDAtVNQVLAsRYGIRGFPtIKIF
Q15293 T100 Sugiyama RCN1 RCN sKERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNV
Q15293 T211 Sugiyama RCN1 RCN FTAFLHPEEFEHMKEIVVLEtLEDIDKNGDGFVDQDEyIAD
Q15427 T14 Sugiyama SF3B4 SAP49 _______MAAGPISERNQDAtVyVGGLDEKVSEPLLWELFL
Q16566 S12 EPSD|PSP CAMK4 CAMK CAMK-GR CAMKIV _________MLKVTVPSCSAssCSSVTASAAPGTASLVPDY
Q16566 S13 EPSD|PSP CAMK4 CAMK CAMK-GR CAMKIV ________MLKVTVPSCSAssCSSVTASAAPGTASLVPDYW
Q16566 T200 GPS6|SIGNOR|iPTMNet|EPSD|PSP CAMK4 CAMK CAMK-GR CAMKIV PLKIADFGLsKIVEHQVLMKtVCGTPGYCAPEILRGCAYGP
Q16576 T10 Sugiyama RBBP7 RBAP46 ___________MAsKEMFEDtVEERVINEEYKIWKKNTPFL
Q3ZCM7 S75 Sugiyama TUBB8 SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q58FF7 S408 Sugiyama HSP90AB3P HSP90BC EPIDEYCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEE
Q58FF8 S308 Sugiyama HSP90AB2P HSP90BB YMTEPIDGYQLKEFDGKsLVsVtKEGLELPEDGEEKKRMEE
Q58FF8 T104 Sugiyama HSP90AB2P HSP90BB LTLVDTGIGMTKADLINNLGtIAKFQDQTEYLEEMQVKEVV
Q5SW79 S552 Sugiyama CEP170 FAM68A KAB KIAA0470 yNRPVINEKHKDLIKDWALssAAAVMEERKPLTTSGFHHsE
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6FI81 S305 Sugiyama CIAPIN1 CUA001 PRO0915 CAsCPyLGMPAFKPGEKVLLsDsNLHDA_____________
Q6PEY2 T51 Sugiyama TUBA3E QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q71U36 T51 Sugiyama TUBA1A TUBA3 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q8IU85 T180 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP CAMK1D CAMKID KIMISDFGLSKMEGKGDVMstACGtPGYVAPEVLAQKPYSK
Q8IV50 T210 Sugiyama LYSMD2 STQAAKKLKEESRDEEsPyAtSLyHs_______________
Q8N1G4 T27 Sugiyama LRRC47 KIAA1185 SESWPELELAERERRRELLLtGPGLEERVRAAGGQLPPRLF
Q8N5S9 S111 Sugiyama CAMKK1 CAMKKA yAtGPAsHIsPRAWRRPtIEsHHVAIsDAEDCVQLNQYKLQ
Q8N5S9 S117 Sugiyama CAMKK1 CAMKKA sHIsPRAWRRPtIEsHHVAIsDAEDCVQLNQYKLQSEIGKG
Q8N5S9 S149 Sugiyama CAMKK1 CAMKKA KLQSEIGKGAYGVVRLAYNEsEDRHYAMKVLSKKKLLKQYG
Q8N5S9 S179 Sugiyama CAMKK1 CAMKKA LSKKKLLKQYGFPRRPPPRGsQAAQGGPAKQLLPLERVYQE
Q8N5S9 S475 Sugiyama CAMKK1 CAMKKA RKRsFGNPFEPQARREERSMsAPGNLLVKEGFGEGGKsPEL
Q8N5S9 S492 Sugiyama CAMKK1 CAMKKA RSMsAPGNLLVKEGFGEGGKsPELPGVQEDEAAS_______
Q8N5S9 S52 Sugiyama CAMKK1 CAMKKA DGGPEPTRNGVDPPPRARAAsVIPGstSRLLPARPsLsARK
Q8N5S9 S57 Sugiyama CAMKK1 CAMKKA PTRNGVDPPPRARAAsVIPGstSRLLPARPsLsARKLsLQE
Q8N5S9 S67 Sugiyama CAMKK1 CAMKKA RARAAsVIPGstSRLLPARPsLsARKLsLQERPAGsyLEAQ
Q8N5S9 S69 Sugiyama CAMKK1 CAMKKA RAAsVIPGstSRLLPARPsLsARKLsLQERPAGsyLEAQAG
Q8N5S9 S82 Sugiyama CAMKK1 CAMKKA LPARPsLsARKLsLQERPAGsyLEAQAGPyAtGPAsHIsPR
Q8N5S9 S97 Sugiyama CAMKK1 CAMKKA ERPAGsyLEAQAGPyAtGPAsHIsPRAWRRPtIEsHHVAIs
Q8N5S9 T108 Sugiyama CAMKK1 CAMKKA AGPyAtGPAsHIsPRAWRRPtIEsHHVAIsDAEDCVQLNQY
Q8N5S9 T26 Sugiyama CAMKK1 CAMKKA AVCCQDPRAELVERVAAIDVtHLEEADGGPEPTRNGVDPPP
Q8N5S9 T430 Sugiyama CAMKK1 CAMKKA TKNGEEPLPSEEEHCSVVEVtEEEVKNSVRLIPSWTTVILV
Q8N5S9 T58 Sugiyama CAMKK1 CAMKKA TRNGVDPPPRARAAsVIPGstSRLLPARPsLsARKLsLQER
Q8N5S9 T93 Sugiyama CAMKK1 CAMKKA LsLQERPAGsyLEAQAGPyAtGPAsHIsPRAWRRPtIEsHH
Q8N5S9 Y91 Sugiyama CAMKK1 CAMKKA RKLsLQERPAGsyLEAQAGPyAtGPAsHIsPRAWRRPtIEs
Q8NBJ5 S616 Sugiyama COLGALT1 GLT25D1 PSEC0241 EQQALSREAKNsDVLQsPLDsAARDEL______________
Q8NBJ7 T260 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 SPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMGNtPD
Q8NBJ7 T42 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 LGNGQATSMVQLQGGRFLMGtNsPDSRDGDGPVREATVKPF
Q8NBS9 T122 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 LGDKYNSMEDAKVYVAKVDCtAHsDVCsAQGVRGYPTLKLF
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TEQ6 T853 Sugiyama GEMIN5 KEKPETLIKKRKARsLLPLstsLDHRSKEELHQDCLVLATA
Q8WU90 T348 Sugiyama ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730 sVNDIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLs
Q99497 T154 Sugiyama PARK7 MNGGHytysENRVEKDGLILtSRGPGTSFEFALAIVEALNG
Q99613 S39 Sugiyama EIF3C EIF3S8 GEELVTKPVGGNyGKQPLLLsEDEEDTKRVVRSAKDKRFEE
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99832 T351 Sugiyama CCT7 CCTH NIP7-1 QtSVNALSADVLGRCQVFEEtQIGGERyNFFtGCPKAKTCt
Q9BQE3 T51 Sugiyama TUBA1C TUBA6 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BUJ2 T113 Sugiyama HNRNPUL1 E1BAP5 HNRPUL1 SGPDGHYAMDNITRQNQFyDtQVIKQENESGyERRPLEMEQ
Q9BVA1 S75 Sugiyama TUBB2B tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BVA1 T72 Sugiyama TUBB2B NEAtGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9BZI7 S166 Sugiyama UPF3B RENT3B UPF3X KRDTKVGtIDDDPEyRKFLEsyAtDNEKMTstPEtLLEEIE
Q9HAP6 S120 Sugiyama LIN7B MALS2 VELI2 UNQ3116/PRO10200 DEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLKRGDQL
Q9NS87 T1158 Sugiyama KIF15 KLP2 KNSL7 DPQsPKtPPHFQTHLAKLLEtQEQEIEDGRAsKTsLEHLVT
Q9NUP9 S120 Sugiyama LIN7C MALS3 VELI3 EEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLKRGDQL
Q9NUQ3 T102 Sugiyama TXLNG CXorf15 ELRG LSR5 EDEGsDFItENRNLVsPAyCtQEsREEIPGGEARTDPPDGQ
Q9UBQ5 T28 Sugiyama EIF3K EIF3S12 ARG134 HSPC029 MSTP001 PTD001 RANVGKLLKGIDRyNPENLAtLERYVETQAKENAyDLEANL
Q9UI15 T190 Sugiyama TAGLN3 NP25 GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9UNF1 T92 Sugiyama MAGED2 BCG1 tPEAREAPAtQAssttQLtDtQVLAAENKSLAADTKKQNAD
Q9UQ80 T386 Sugiyama PA2G4 EBP1 tQKKKKKKAsKtAENAtsGEtLEENEAGD____________
Q9UQN3 T124 Sugiyama CHMP2B CGI-84 TTAKTMQAVNKKMDPQKTLQtMQNFQKENMKMEMTEEMIND
Q9Y2B0 T79 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 NPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGEQIDPs
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cellular Senescence R-HSA-2559583 0.000012 4.932 0 0
Cell Cycle R-HSA-1640170 0.000022 4.661 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.000023 4.645 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.000031 4.503 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.000031 4.503 0 0
Apoptotic execution phase R-HSA-75153 0.000035 4.462 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.000065 4.190 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.000069 4.159 0 0
Signaling by VEGF R-HSA-194138 0.000064 4.195 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.000057 4.244 0 0
RAF activation R-HSA-5673000 0.000101 3.997 0 0
Oncogene Induced Senescence R-HSA-2559585 0.000121 3.919 0 0
Cell Cycle, Mitotic R-HSA-69278 0.000129 3.888 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.000219 3.659 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.000252 3.598 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.000370 3.432 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.000464 3.334 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.000464 3.334 0 0
Cellular responses to stimuli R-HSA-8953897 0.000560 3.252 0 0
Signaling by RAS mutants R-HSA-6802949 0.000733 3.135 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.000733 3.135 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.000733 3.135 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.000733 3.135 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 0.001057 2.976 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.001057 2.976 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.000983 3.008 0 0
M Phase R-HSA-68886 0.001075 2.968 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.001343 2.872 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.001343 2.872 0 0
Post NMDA receptor activation events R-HSA-438064 0.001281 2.892 1 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.001496 2.825 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.001496 2.825 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.001422 2.847 0 0
Cell Cycle Checkpoints R-HSA-69620 0.001511 2.821 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.001643 2.784 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.001702 2.769 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.001702 2.769 1 0
Muscle contraction R-HSA-397014 0.001668 2.778 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.001919 2.717 0 0
Striated Muscle Contraction R-HSA-390522 0.002122 2.673 0 0
Mitotic Anaphase R-HSA-68882 0.002038 2.691 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.002141 2.669 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.002663 2.575 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 0.002446 2.612 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 0.002446 2.612 0 0
Regulation of CDH11 function R-HSA-9762292 0.002727 2.564 0 0
Long-term potentiation R-HSA-9620244 0.002663 2.575 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.002727 2.564 1 1
Cellular responses to stress R-HSA-2262752 0.002511 2.600 0 0
Apoptosis R-HSA-109581 0.002905 2.537 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.003317 2.479 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 0.003583 2.446 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.003623 2.441 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.003761 2.425 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.004106 2.387 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 0.004516 2.345 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.005188 2.285 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.005651 2.248 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.005455 2.263 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.005882 2.230 0 0
Regulation of TP53 Activity R-HSA-5633007 0.005992 2.222 0 0
Separation of Sister Chromatids R-HSA-2467813 0.007316 2.136 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 0.006962 2.157 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 0.007499 2.125 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.008134 2.090 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.008498 2.071 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.008674 2.062 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.009296 2.032 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.009951 2.002 0 0
FOXO-mediated transcription R-HSA-9614085 0.010089 1.996 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 0.010154 1.993 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.010154 1.993 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.010836 1.965 0 0
mRNA Editing: A to I Conversion R-HSA-75064 0.013532 1.869 0 0
Diseases of cellular response to stress R-HSA-9675132 0.013532 1.869 0 0
Diseases of Cellular Senescence R-HSA-9630747 0.013532 1.869 0 0
C6 deamination of adenosine R-HSA-75102 0.013532 1.869 0 0
Signaling by RAS GAP mutants R-HSA-9753510 0.013532 1.869 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.012054 1.919 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.013654 1.865 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.013885 1.857 0 0
Signaling by PTK6 R-HSA-8848021 0.013885 1.857 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.012847 1.891 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.013956 1.855 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.014168 1.849 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.014168 1.849 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 0.016158 1.792 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 0.016158 1.792 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.015722 1.804 0 0
Neurexins and neuroligins R-HSA-6794361 0.017469 1.758 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.019064 1.720 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.019064 1.720 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.018983 1.722 0 0
Smooth Muscle Contraction R-HSA-445355 0.018915 1.723 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.019685 1.706 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.019903 1.701 0 0
FLT3 Signaling R-HSA-9607240 0.019961 1.700 0 0
MAP2K and MAPK activation R-HSA-5674135 0.021802 1.662 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.021802 1.662 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.021802 1.662 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.021802 1.662 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.021859 1.660 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.021891 1.660 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.024049 1.619 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.024049 1.619 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.023603 1.627 0 0
Programmed Cell Death R-HSA-5357801 0.022292 1.652 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 0.024086 1.618 0 0
Trafficking of AMPA receptors R-HSA-399719 0.024251 1.615 0 0
Downstream signal transduction R-HSA-186763 0.024251 1.615 0 0
Signal Transduction R-HSA-162582 0.025252 1.598 1 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.028166 1.550 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 0.028762 1.541 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.028706 1.542 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.028706 1.542 0 0
Mitotic Prometaphase R-HSA-68877 0.026269 1.581 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.026770 1.572 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 0.028762 1.541 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.028002 1.553 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.029449 1.531 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.029449 1.531 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.029449 1.531 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.031684 1.499 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.031793 1.498 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.033761 1.472 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.033761 1.472 0 0
Activation of AKT2 R-HSA-165158 0.038056 1.420 0 0
Notch-HLH transcription pathway R-HSA-350054 0.035449 1.450 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.037401 1.427 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.035449 1.450 0 0
MAPK family signaling cascades R-HSA-5683057 0.034946 1.457 0 0
EPH-Ephrin signaling R-HSA-2682334 0.037335 1.428 0 0
NrCAM interactions R-HSA-447038 0.038056 1.420 0 0
Signaling by KIT in disease R-HSA-9669938 0.035449 1.450 0 0
Semaphorin interactions R-HSA-373755 0.038184 1.418 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.038475 1.415 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.038567 1.414 0 0
Signaling by ALK in cancer R-HSA-9700206 0.038567 1.414 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.039245 1.406 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.039461 1.404 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.040725 1.390 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.040725 1.390 0 0
Cell-Cell communication R-HSA-1500931 0.041598 1.381 0 0
FLT3 signaling in disease R-HSA-9682385 0.041820 1.379 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.041820 1.379 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 0.042659 1.370 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 0.042659 1.370 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 0.042659 1.370 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 0.042659 1.370 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.043644 1.360 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.043722 1.359 0 0
Neurodegenerative Diseases R-HSA-8863678 0.043722 1.359 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.048230 1.317 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.043722 1.359 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.048325 1.316 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.048325 1.316 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 0.048325 1.316 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.048325 1.316 0 0
Erythropoietin activates RAS R-HSA-9027284 0.051473 1.288 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.051473 1.288 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.051473 1.288 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.051473 1.288 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 0.051473 1.288 0 0
Phosphorylation of the APC/C R-HSA-176412 0.058197 1.235 0 0
Cristae formation R-HSA-8949613 0.057987 1.237 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.053170 1.274 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.060169 1.221 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.054370 1.265 0 0
Interferon alpha/beta signaling R-HSA-909733 0.059687 1.224 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.059467 1.226 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.053170 1.274 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.052699 1.278 0 0
Cellular response to chemical stress R-HSA-9711123 0.052038 1.284 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.058197 1.235 0 0
Chromatin modifying enzymes R-HSA-3247509 0.057166 1.243 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.058197 1.235 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.057987 1.237 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.057427 1.241 0 0
Signaling by NOTCH3 R-HSA-9012852 0.060169 1.221 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.052877 1.277 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.060588 1.218 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.060588 1.218 0 0
S Phase R-HSA-69242 0.063771 1.195 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.063864 1.195 0 0
Rab regulation of trafficking R-HSA-9007101 0.064665 1.189 0 0
Mitochondrial biogenesis R-HSA-1592230 0.064665 1.189 0 0
Cell junction organization R-HSA-446728 0.067636 1.170 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.067690 1.169 0 0
Signaling by Erythropoietin R-HSA-9006335 0.068716 1.163 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.069902 1.156 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 0.083501 1.078 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 0.083501 1.078 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 0.083501 1.078 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 0.083501 1.078 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 0.083501 1.078 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.071392 1.146 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.079580 1.099 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.074437 1.128 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 0.071392 1.146 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 0.084011 1.076 1 1
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.075400 1.123 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.072804 1.138 0 0
Inhibition of PKR R-HSA-169131 0.083501 1.078 0 0
SOS-mediated signalling R-HSA-112412 0.071392 1.146 0 0
Activation of RAS in B cells R-HSA-1169092 0.084011 1.076 0 0
Synaptic adhesion-like molecules R-HSA-8849932 0.080662 1.093 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.080392 1.095 0 0
Ca-dependent events R-HSA-111996 0.070020 1.155 1 0
Signaling by Hippo R-HSA-2028269 0.072804 1.138 0 0
RSV-host interactions R-HSA-9833110 0.071157 1.148 0 0
MTOR signalling R-HSA-165159 0.070020 1.155 0 0
PTEN Regulation R-HSA-6807070 0.083970 1.076 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.084011 1.076 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.074731 1.126 0 0
Signaling by SCF-KIT R-HSA-1433557 0.074731 1.126 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.084294 1.074 0 0
Chromatin organization R-HSA-4839726 0.085362 1.069 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.085970 1.066 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 0.122603 0.912 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 0.122603 0.912 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 0.122603 0.912 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 0.122603 0.912 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 0.122603 0.912 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 0.122603 0.912 0 0
XAV939 stabilizes AXIN R-HSA-5545619 0.122603 0.912 0 0
Regulation of cortical dendrite branching R-HSA-8985801 0.160038 0.796 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 0.160038 0.796 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 0.195879 0.708 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 0.195879 0.708 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 0.195879 0.708 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.097243 1.012 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.230193 0.638 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.230193 0.638 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.230193 0.638 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 0.230193 0.638 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 0.230193 0.638 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 0.230193 0.638 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 0.230193 0.638 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.111015 0.955 0 0
2-LTR circle formation R-HSA-164843 0.111015 0.955 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 0.111015 0.955 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.125255 0.902 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.263044 0.580 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.263044 0.580 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 0.263044 0.580 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 0.139900 0.854 0 0
Activation of RAC1 R-HSA-428540 0.139900 0.854 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.139900 0.854 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.139900 0.854 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.088868 1.051 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.154888 0.810 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.154888 0.810 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.154888 0.810 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.154888 0.810 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.154888 0.810 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 0.294495 0.531 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 0.294495 0.531 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 0.294495 0.531 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.294495 0.531 0 0
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) R-HSA-5619063 0.294495 0.531 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.170163 0.769 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.170163 0.769 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.106267 0.974 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.115426 0.938 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.185675 0.731 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.324606 0.489 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 0.324606 0.489 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.124871 0.904 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.201375 0.696 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.201375 0.696 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.217219 0.663 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.353433 0.452 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.353433 0.452 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.353433 0.452 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 0.353433 0.452 0 0
IFNG signaling activates MAPKs R-HSA-9732724 0.353433 0.452 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 0.353433 0.452 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.095236 1.021 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.249180 0.603 0 0
Type I hemidesmosome assembly R-HSA-446107 0.381032 0.419 0 0
phospho-PLA2 pathway R-HSA-111995 0.381032 0.419 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.143584 0.843 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.265224 0.576 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.197527 0.704 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.124432 0.905 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.208640 0.681 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.281268 0.551 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.407454 0.390 0 0
CASP8 activity is inhibited R-HSA-5218900 0.407454 0.390 0 0
ALK mutants bind TKIs R-HSA-9700645 0.407454 0.390 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.130717 0.884 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 0.297281 0.527 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 0.297281 0.527 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.297281 0.527 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.297281 0.527 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.297281 0.527 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.297281 0.527 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.432750 0.364 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.211515 0.675 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.178429 0.749 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.178429 0.749 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.178429 0.749 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.178429 0.749 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.178429 0.749 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.289371 0.539 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.223709 0.650 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.267253 0.573 0 0
Meiotic synapsis R-HSA-1221632 0.276804 0.558 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.391403 0.407 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.322150 0.492 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.374133 0.427 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.374133 0.427 0 0
Neutrophil degranulation R-HSA-6798695 0.150060 0.824 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.312905 0.505 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.327781 0.484 0 0
mRNA Splicing R-HSA-72172 0.387396 0.412 0 0
PKR-mediated signaling R-HSA-9833482 0.189359 0.723 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.430805 0.366 0 0
Co-inhibition by PD-1 R-HSA-389948 0.166138 0.780 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.171244 0.766 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.325220 0.488 0 0
Signaling by NOTCH1 R-HSA-1980143 0.305271 0.515 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.165155 0.782 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.106455 0.973 0 0
DNA Double Strand Break Response R-HSA-5693606 0.231574 0.635 0 0
Nephrin family interactions R-HSA-373753 0.297281 0.527 0 0
TRAIL signaling R-HSA-75158 0.294495 0.531 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.170163 0.769 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 0.432750 0.364 0 0
Regulation of the apoptosome activity R-HSA-9627069 0.432750 0.364 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.193128 0.714 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.371918 0.430 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.132748 0.877 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.233167 0.632 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.325220 0.488 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 0.124871 0.904 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.092980 1.032 0 0
Telomere Extension By Telomerase R-HSA-171319 0.186564 0.729 0 0
Polo-like kinase mediated events R-HSA-156711 0.265224 0.576 0 0
Formation of apoptosome R-HSA-111458 0.432750 0.364 0 0
RNA Polymerase III Transcription R-HSA-74158 0.289371 0.539 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.189996 0.721 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.301152 0.521 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.265926 0.575 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.201910 0.695 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.249634 0.603 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 0.097243 1.012 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 0.294495 0.531 0 0
Formation of axial mesoderm R-HSA-9796292 0.170163 0.769 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.281268 0.551 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 0.407454 0.390 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.391403 0.407 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.391403 0.407 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.101158 0.995 0 0
Myogenesis R-HSA-525793 0.165155 0.782 0 0
mRNA Editing R-HSA-75072 0.097243 1.012 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 0.324606 0.489 0 0
PTK6 Expression R-HSA-8849473 0.353433 0.452 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 0.353433 0.452 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.175768 0.755 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 0.381032 0.419 0 0
Integrin signaling R-HSA-354192 0.242728 0.615 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.242728 0.615 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.373255 0.428 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.278598 0.555 0 0
Interferon Signaling R-HSA-913531 0.172468 0.763 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.222464 0.653 0 0
Cyclin D associated events in G1 R-HSA-69231 0.395282 0.403 0 0
G1 Phase R-HSA-69236 0.395282 0.403 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.337418 0.472 0 0
Signaling by WNT in cancer R-HSA-4791275 0.086574 1.063 0 0
Regulation of CDH1 Function R-HSA-9764561 0.157226 0.803 0 0
Meiosis R-HSA-1500620 0.381796 0.418 0 0
Frs2-mediated activation R-HSA-170968 0.170163 0.769 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.208640 0.681 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.295119 0.530 0 0
Adipogenesis R-HSA-9843745 0.313498 0.504 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 0.294495 0.531 0 0
Lipophagy R-HSA-9613354 0.407454 0.390 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.280223 0.552 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.415777 0.381 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.406879 0.391 0 0
Somitogenesis R-HSA-9824272 0.202559 0.693 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.348388 0.458 0 0
Interferon gamma signaling R-HSA-877300 0.367686 0.435 0 0
Circadian clock R-HSA-9909396 0.319861 0.495 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.092980 1.032 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.154888 0.810 0 0
IRS-mediated signalling R-HSA-112399 0.315479 0.501 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.245293 0.610 0 0
DAP12 signaling R-HSA-2424491 0.208640 0.681 0 0
Prolonged ERK activation events R-HSA-169893 0.217219 0.663 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.140249 0.853 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.295847 0.529 0 0
Manipulation of host energy metabolism R-HSA-9636667 0.122603 0.912 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 0.160038 0.796 0 0
Dopamine receptors R-HSA-390651 0.230193 0.638 0 0
Ionotropic activity of kainate receptors R-HSA-451306 0.125255 0.902 0 0
Suppression of autophagy R-HSA-9636569 0.263044 0.580 0 0
PDE3B signalling R-HSA-165160 0.294495 0.531 0 0
PKB-mediated events R-HSA-109703 0.294495 0.531 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 0.294495 0.531 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.170163 0.769 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.201375 0.696 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.092980 1.032 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.154742 0.810 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.233167 0.632 0 0
Metalloprotease DUBs R-HSA-5689901 0.165155 0.782 0 0
Regulation by c-FLIP R-HSA-3371378 0.381032 0.419 0 0
Fructose biosynthesis R-HSA-5652227 0.381032 0.419 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 0.186564 0.729 0 0
Apoptotic factor-mediated response R-HSA-111471 0.265224 0.576 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.265224 0.576 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.432750 0.364 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.329115 0.483 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.265926 0.575 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.286410 0.543 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.288530 0.540 0 0
Selective autophagy R-HSA-9663891 0.415874 0.381 0 0
G-protein beta:gamma signalling R-HSA-397795 0.092980 1.032 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.280223 0.552 0 0
G2/M Transition R-HSA-69275 0.118280 0.927 0 0
Interleukin-9 signaling R-HSA-8985947 0.381032 0.419 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.124568 0.905 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.255614 0.592 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.277624 0.557 0 0
Mitotic Prophase R-HSA-68875 0.135968 0.867 0 0
Signalling to ERKs R-HSA-187687 0.113484 0.945 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.175768 0.755 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.193128 0.714 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.189359 0.723 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.265224 0.576 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.354566 0.450 0 0
G2/M Checkpoints R-HSA-69481 0.282113 0.550 0 0
Membrane Trafficking R-HSA-199991 0.117393 0.930 0 0
Pervasive developmental disorders R-HSA-9005895 0.154888 0.810 0 0
Disorders of Nervous System Development R-HSA-9697154 0.154888 0.810 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.154888 0.810 0 0
p38MAPK events R-HSA-171007 0.201375 0.696 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 0.249180 0.603 0 0
Degradation of CDH1 R-HSA-9766229 0.106455 0.973 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 0.407454 0.390 0 0
Interleukin-21 signaling R-HSA-9020958 0.407454 0.390 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 0.407454 0.390 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.432750 0.364 0 0
Formation of intermediate mesoderm R-HSA-9761174 0.432750 0.364 0 0
Mitochondrial calcium ion transport R-HSA-8949215 0.329115 0.483 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.344889 0.462 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.344889 0.462 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.312956 0.505 0 0
HATs acetylate histones R-HSA-3214847 0.207972 0.682 0 0
Heme signaling R-HSA-9707616 0.364353 0.438 0 0
Calmodulin induced events R-HSA-111933 0.120726 0.918 1 0
PIP3 activates AKT signaling R-HSA-1257604 0.400922 0.397 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.157226 0.803 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.329115 0.483 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.120662 0.918 0 0
RUNX2 regulates bone development R-HSA-8941326 0.120726 0.918 0 0
CaM pathway R-HSA-111997 0.120726 0.918 1 0
PLC beta mediated events R-HSA-112043 0.185725 0.731 1 0
COPII-mediated vesicle transport R-HSA-204005 0.255614 0.592 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.386390 0.413 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.237696 0.624 1 0
Co-stimulation by CD28 R-HSA-389356 0.229744 0.639 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.113484 0.945 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.093367 1.030 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.211515 0.675 0 0
ER-Phagosome pathway R-HSA-1236974 0.258366 0.588 0 0
Kinesins R-HSA-983189 0.344779 0.462 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.176501 0.753 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.406582 0.391 0 0
Netrin-1 signaling R-HSA-373752 0.395282 0.403 0 0
IGF1R signaling cascade R-HSA-2428924 0.383900 0.416 0 0
Adaptive Immune System R-HSA-1280218 0.319088 0.496 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.193128 0.714 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.172468 0.763 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.142399 0.846 1 0
G1/S Transition R-HSA-69206 0.269798 0.569 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.151566 0.819 0 0
Breakdown of the nuclear lamina R-HSA-352238 0.122603 0.912 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 0.263044 0.580 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.154888 0.810 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 0.294495 0.531 0 0
Disorders of Developmental Biology R-HSA-9675151 0.233167 0.632 0 0
Phase 2 - plateau phase R-HSA-5576893 0.233167 0.632 0 0
Dimerization of procaspase-8 R-HSA-69416 0.381032 0.419 0 0
Nucleotide salvage defects R-HSA-9734207 0.381032 0.419 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.143584 0.843 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.265224 0.576 0 0
ARMS-mediated activation R-HSA-170984 0.407454 0.390 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.242728 0.615 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.313239 0.504 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.178429 0.749 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.376050 0.425 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.324771 0.488 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.336585 0.473 0 0
Adherens junctions interactions R-HSA-418990 0.102867 0.988 0 0
Cell-cell junction organization R-HSA-421270 0.140572 0.852 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.139177 0.856 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.139177 0.856 0 0
DAG and IP3 signaling R-HSA-1489509 0.202559 0.693 1 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.356177 0.448 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.290013 0.538 0 0
Neuronal System R-HSA-112316 0.306286 0.514 1 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.393650 0.405 0 0
ESR-mediated signaling R-HSA-8939211 0.236523 0.626 0 0
Axon guidance R-HSA-422475 0.274185 0.562 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.406879 0.391 0 0
MET activates RAS signaling R-HSA-8851805 0.154888 0.810 0 0
Interleukin-6 signaling R-HSA-1059683 0.170163 0.769 0 0
Signalling to RAS R-HSA-167044 0.313239 0.504 0 0
Transmission across Chemical Synapses R-HSA-112315 0.427026 0.370 1 0
Diseases of programmed cell death R-HSA-9645723 0.251165 0.600 0 0
G-protein mediated events R-HSA-112040 0.231574 0.635 1 0
Suppression of apoptosis R-HSA-9635465 0.125255 0.902 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.115426 0.938 0 0
Diseases of Immune System R-HSA-5260271 0.151556 0.819 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.151556 0.819 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.407454 0.390 0 0
Receptor Mediated Mitophagy R-HSA-8934903 0.432750 0.364 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.277624 0.557 0 0
NRAGE signals death through JNK R-HSA-193648 0.305754 0.515 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.422733 0.374 0 0
Nervous system development R-HSA-9675108 0.321158 0.493 0 0
Ephrin signaling R-HSA-3928664 0.265224 0.576 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.348388 0.458 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.406582 0.391 0 0
DAP12 interactions R-HSA-2172127 0.395282 0.403 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.413493 0.384 0 0
Stabilization of p53 R-HSA-69541 0.324771 0.488 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.092980 1.032 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 0.125255 0.902 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 0.263044 0.580 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 0.263044 0.580 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 0.139900 0.854 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.201375 0.696 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 0.134583 0.871 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 0.233167 0.632 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 0.381032 0.419 0 0
Calcitonin-like ligand receptors R-HSA-419812 0.381032 0.419 0 0
RSK activation R-HSA-444257 0.381032 0.419 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 0.407454 0.390 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.407454 0.390 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 0.313239 0.504 0 0
Interleukin-27 signaling R-HSA-9020956 0.432750 0.364 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 0.329115 0.483 0 0
HSF1-dependent transactivation R-HSA-3371571 0.257764 0.589 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 0.376050 0.425 0 0
Deadenylation of mRNA R-HSA-429947 0.376050 0.425 0 0
TGFBR3 expression R-HSA-9839394 0.391403 0.407 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.406582 0.391 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 0.421577 0.375 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.374133 0.427 0 0
Cellular response to heat stress R-HSA-3371556 0.375192 0.426 0 0
Immune System R-HSA-168256 0.281120 0.551 0 0
Insulin receptor signalling cascade R-HSA-74751 0.383900 0.416 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.424709 0.372 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.305754 0.515 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.313239 0.504 0 0
HDMs demethylate histones R-HSA-3214842 0.391403 0.407 0 0
Ion homeostasis R-HSA-5578775 0.305754 0.515 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.391403 0.407 0 0
Pyruvate metabolism R-HSA-70268 0.407374 0.390 0 0
Proteasome assembly R-HSA-9907900 0.395282 0.403 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.407454 0.390 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.329115 0.483 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.193128 0.714 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.344889 0.462 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.391403 0.407 0 0
Deubiquitination R-HSA-5688426 0.422699 0.374 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.100767 0.997 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.347648 0.459 0 0
Glycolysis R-HSA-70171 0.214102 0.669 0 0
Integration of provirus R-HSA-162592 0.139900 0.854 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.208640 0.681 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.344779 0.462 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.234248 0.630 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.397556 0.401 0 0
Signaling by FGFR in disease R-HSA-1226099 0.151924 0.818 0 0
Diseases of DNA repair R-HSA-9675135 0.418410 0.378 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 0.160038 0.796 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.097243 1.012 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 0.263044 0.580 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 0.154888 0.810 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 0.294495 0.531 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 0.294495 0.531 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 0.201375 0.696 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 0.407454 0.390 0 0
Co-inhibition by CTLA4 R-HSA-389513 0.297281 0.527 0 0
Basigin interactions R-HSA-210991 0.313239 0.504 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.086743 1.062 0 0
G alpha (12/13) signalling events R-HSA-416482 0.322150 0.492 0 0
Interleukin-20 family signaling R-HSA-8854691 0.360540 0.443 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.398053 0.400 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.317138 0.499 0 0
CREB3 factors activate genes R-HSA-8874211 0.324606 0.489 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.135783 0.867 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 0.313239 0.504 0 0
Other interleukin signaling R-HSA-449836 0.281268 0.551 0 0
Ion transport by P-type ATPases R-HSA-936837 0.208234 0.681 0 0
Interleukin-6 family signaling R-HSA-6783589 0.376050 0.425 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.431392 0.365 0 0
Interleukin-12 family signaling R-HSA-447115 0.130216 0.885 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.111015 0.955 0 0
Cellular response to mitochondrial stress R-HSA-9840373 0.407454 0.390 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 0.407454 0.390 0 0
Josephin domain DUBs R-HSA-5689877 0.432750 0.364 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.145703 0.837 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.129055 0.889 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.121958 0.914 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.376050 0.425 0 0
Glucose metabolism R-HSA-70326 0.347176 0.459 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 0.125255 0.902 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 0.263044 0.580 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.154888 0.810 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.353433 0.452 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 0.233167 0.632 0 0
TRP channels R-HSA-3295583 0.165155 0.782 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.265224 0.576 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 0.360540 0.443 0 0
Signaling by ERBB2 R-HSA-1227986 0.178429 0.749 0 0
Signaling by PDGF R-HSA-186797 0.193128 0.714 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.154888 0.810 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 0.154888 0.810 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 0.353433 0.452 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.339131 0.470 0 0
Signaling by FGFR4 R-HSA-5654743 0.383625 0.416 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.244581 0.612 0 0
Ion channel transport R-HSA-983712 0.301332 0.521 0 0
Suppression of phagosomal maturation R-HSA-9637687 0.406582 0.391 0 0
Signaling by FGFR3 R-HSA-5654741 0.406879 0.391 0 0
Maturation of nucleoprotein R-HSA-9683610 0.170163 0.769 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.106267 0.974 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.249180 0.603 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.249180 0.603 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.281268 0.551 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.170163 0.769 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.406582 0.391 0 0
Dissolution of Fibrin Clot R-HSA-75205 0.125255 0.902 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.406582 0.391 0 0
Stimuli-sensing channels R-HSA-2672351 0.424709 0.372 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.395282 0.403 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.233625 0.631 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.313239 0.504 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.313239 0.504 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.102944 0.987 0 0
Signaling by EGFR R-HSA-177929 0.305754 0.515 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.313239 0.504 0 0
Regulation of beta-cell development R-HSA-186712 0.171244 0.766 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.406582 0.391 0 0
Tie2 Signaling R-HSA-210993 0.265224 0.576 0 0
Maturation of nucleoprotein R-HSA-9694631 0.281268 0.551 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.344889 0.462 0 0
Signaling by ALK R-HSA-201556 0.324771 0.488 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.185675 0.731 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.150749 0.822 0 0
Interleukin-12 signaling R-HSA-9020591 0.164015 0.785 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.329115 0.483 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.421577 0.375 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.421577 0.375 0 0
MHC class II antigen presentation R-HSA-2132295 0.389249 0.410 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.432810 0.364 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.436374 0.360 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.436374 0.360 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.436374 0.360 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.436374 0.360 0 0
NGF-stimulated transcription R-HSA-9031628 0.441239 0.355 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.441240 0.355 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.441240 0.355 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.441934 0.355 0 0
Gastrulation R-HSA-9758941 0.443185 0.353 0 0
Generic Transcription Pathway R-HSA-212436 0.446493 0.350 0 0
IRE1alpha activates chaperones R-HSA-381070 0.449640 0.347 0 0
Platelet calcium homeostasis R-HSA-418360 0.450963 0.346 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.450963 0.346 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.450963 0.346 0 0
Regulation of gene expression in beta cells R-HSA-210745 0.450963 0.346 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.451464 0.345 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.451464 0.345 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.451464 0.345 0 0
Inositol phosphate metabolism R-HSA-1483249 0.455123 0.342 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.456968 0.340 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.456968 0.340 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.456968 0.340 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.456968 0.340 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 0.456968 0.340 0 0
vRNP Assembly R-HSA-192905 0.456968 0.340 0 0
Signaling by APC mutants R-HSA-4839744 0.456968 0.340 0 0
Synthesis of PI R-HSA-1483226 0.456968 0.340 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 0.456968 0.340 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 0.456968 0.340 0 0
Cardiac conduction R-HSA-5576891 0.459295 0.338 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.462615 0.335 0 0
Vesicle-mediated transport R-HSA-5653656 0.465331 0.332 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.465335 0.332 0 0
Activation of the pre-replicative complex R-HSA-68962 0.465335 0.332 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.465335 0.332 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.465335 0.332 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.465335 0.332 0 0
Interleukin-37 signaling R-HSA-9008059 0.465335 0.332 0 0
Activation of BH3-only proteins R-HSA-114452 0.465335 0.332 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.470360 0.328 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.470360 0.328 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.479482 0.319 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.479482 0.319 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.479482 0.319 0 0
Signaling by ERBB4 R-HSA-1236394 0.479718 0.319 0 0
Signaling by NOTCH4 R-HSA-9013694 0.479718 0.319 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 0.480153 0.319 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.480153 0.319 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 0.480153 0.319 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 0.480153 0.319 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 0.480153 0.319 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.480153 0.319 0 0
Signaling by AXIN mutants R-HSA-4839735 0.480153 0.319 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.480153 0.319 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.484783 0.314 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.485148 0.314 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.485782 0.314 0 0
Centrosome maturation R-HSA-380287 0.489011 0.311 0 0
Protein ubiquitination R-HSA-8852135 0.489011 0.311 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.489011 0.311 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.491083 0.309 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.491083 0.309 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.493397 0.307 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.496652 0.304 0 0
UCH proteinases R-HSA-5689603 0.498236 0.303 0 0
Signaling by ROBO receptors R-HSA-376176 0.501793 0.299 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 0.502349 0.299 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 0.502349 0.299 0 0
Regulation of IFNG signaling R-HSA-877312 0.502349 0.299 0 0
Interleukin-35 Signalling R-HSA-8984722 0.502349 0.299 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 0.502349 0.299 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 0.502349 0.299 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 0.502349 0.299 0 0
OAS antiviral response R-HSA-8983711 0.502349 0.299 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.507074 0.295 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.507074 0.295 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 0.507074 0.295 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.507074 0.295 0 0
Cardiogenesis R-HSA-9733709 0.507074 0.295 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.507074 0.295 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.514637 0.288 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.518037 0.286 0 0
HDACs deacetylate histones R-HSA-3214815 0.518037 0.286 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.520508 0.284 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.520508 0.284 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.520508 0.284 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.520508 0.284 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.520508 0.284 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.523599 0.281 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.523599 0.281 0 0
Processing of SMDT1 R-HSA-8949664 0.523599 0.281 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.523599 0.281 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 0.523599 0.281 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.523599 0.281 0 0
Diseases of nucleotide metabolism R-HSA-9735804 0.523599 0.281 0 0
CD28 dependent Vav1 pathway R-HSA-389359 0.523599 0.281 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 0.523599 0.281 0 0
Sensory processing of sound R-HSA-9659379 0.525462 0.279 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.528545 0.277 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.528545 0.277 0 0
Signaling by FGFR1 R-HSA-5654736 0.528545 0.277 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 0.533695 0.273 0 0
Mitophagy R-HSA-5205647 0.533695 0.273 0 0
Nuclear import of Rev protein R-HSA-180746 0.533695 0.273 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.533695 0.273 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 0.533695 0.273 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.533695 0.273 0 0
Macroautophagy R-HSA-1632852 0.534120 0.272 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.534379 0.272 0 0
Signaling by MET R-HSA-6806834 0.534379 0.272 0 0
Signaling by FGFR2 R-HSA-5654738 0.534379 0.272 0 0
Signaling by Interleukins R-HSA-449147 0.539057 0.268 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.543211 0.265 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.543943 0.264 0 0
Hydrolysis of LPC R-HSA-1483115 0.543943 0.264 0 0
Physiological factors R-HSA-5578768 0.543943 0.264 0 0
Regulation of KIT signaling R-HSA-1433559 0.543943 0.264 0 0
Signal regulatory protein family interactions R-HSA-391160 0.543943 0.264 0 0
Acyl chain remodeling of CL R-HSA-1482798 0.543943 0.264 0 0
Zinc transporters R-HSA-435354 0.543943 0.264 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 0.543943 0.264 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.546631 0.262 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.546631 0.262 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.546631 0.262 0 0
PI Metabolism R-HSA-1483255 0.547037 0.262 0 0
RNA Polymerase II Transcription R-HSA-73857 0.555252 0.256 0 0
Formation of the cornified envelope R-HSA-6809371 0.557591 0.254 0 0
Extension of Telomeres R-HSA-180786 0.559280 0.252 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.559280 0.252 0 0
GPVI-mediated activation cascade R-HSA-114604 0.559314 0.252 0 0
RET signaling R-HSA-8853659 0.559314 0.252 0 0
G1/S-Specific Transcription R-HSA-69205 0.559314 0.252 0 0
Opioid Signalling R-HSA-111885 0.562482 0.250 1 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.563419 0.249 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.563419 0.249 0 0
DCC mediated attractive signaling R-HSA-418885 0.563419 0.249 0 0
Telomere C-strand synthesis initiation R-HSA-174430 0.563419 0.249 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 0.563419 0.249 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 0.563419 0.249 0 0
Other semaphorin interactions R-HSA-416700 0.563419 0.249 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 0.563419 0.249 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.563419 0.249 0 0
Innate Immune System R-HSA-168249 0.565843 0.247 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.569178 0.245 0 0
RAB geranylgeranylation R-HSA-8873719 0.569253 0.245 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.571513 0.243 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.571513 0.243 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.571513 0.243 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.571741 0.243 0 0
Degradation of AXIN R-HSA-4641257 0.571741 0.243 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.571741 0.243 0 0
Signaling by NOTCH R-HSA-157118 0.580641 0.236 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 0.582065 0.235 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 0.582065 0.235 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.582065 0.235 0 0
Differentiation of T cells R-HSA-9945266 0.582065 0.235 0 0
Negative regulation of FLT3 R-HSA-9706369 0.582065 0.235 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.582065 0.235 0 0
MET promotes cell motility R-HSA-8875878 0.583912 0.234 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.583912 0.234 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.585139 0.233 0 0
Platelet degranulation R-HSA-114608 0.585217 0.233 0 0
Signaling by NTRKs R-HSA-166520 0.585845 0.232 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.586025 0.232 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.586809 0.232 0 0
tRNA processing in the nucleus R-HSA-6784531 0.588776 0.230 0 0
Mitochondrial protein import R-HSA-1268020 0.588776 0.230 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.588776 0.230 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.592549 0.227 0 0
Synthesis of DNA R-HSA-69239 0.592549 0.227 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.594304 0.226 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.595826 0.225 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.595826 0.225 0 0
RAS processing R-HSA-9648002 0.595826 0.225 0 0
Pentose phosphate pathway R-HSA-71336 0.595826 0.225 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.595826 0.225 0 0
Gene expression (Transcription) R-HSA-74160 0.596706 0.224 0 0
Potential therapeutics for SARS R-HSA-9679191 0.598330 0.223 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.599886 0.222 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.599886 0.222 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.599915 0.222 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 0.599915 0.222 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.599915 0.222 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.599915 0.222 0 0
Synthesis of PG R-HSA-1483148 0.599915 0.222 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.599915 0.222 0 0
Galactose catabolism R-HSA-70370 0.599915 0.222 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.602500 0.220 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.604272 0.219 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.607482 0.216 0 0
Aggrephagy R-HSA-9646399 0.607482 0.216 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.607482 0.216 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.607482 0.216 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.607482 0.216 0 0
Generation of second messenger molecules R-HSA-202433 0.607482 0.216 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.610009 0.215 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.610562 0.214 0 0
Peptide chain elongation R-HSA-156902 0.610562 0.214 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.610618 0.214 0 0
TCR signaling R-HSA-202403 0.614332 0.212 0 0
DNA Replication R-HSA-69306 0.616687 0.210 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.617004 0.210 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 0.617004 0.210 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 0.617004 0.210 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.617004 0.210 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 0.617004 0.210 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.618881 0.208 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.618881 0.208 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.625907 0.203 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.628469 0.202 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.628469 0.202 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.628669 0.202 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.629728 0.201 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.630024 0.201 0 0
Intra-Golgi traffic R-HSA-6811438 0.630024 0.201 0 0
Translation of Structural Proteins R-HSA-9683701 0.630024 0.201 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.631326 0.200 0 0
Influenza Infection R-HSA-168255 0.632521 0.199 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.633364 0.198 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.633364 0.198 0 0
Platelet sensitization by LDL R-HSA-432142 0.633364 0.198 0 0
GAB1 signalosome R-HSA-180292 0.633364 0.198 0 0
Autophagy R-HSA-9612973 0.634581 0.198 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.635029 0.197 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.635419 0.197 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.640911 0.193 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.640911 0.193 0 0
Depyrimidination R-HSA-73928 0.640911 0.193 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.641849 0.193 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.642688 0.192 0 0
Cellular response to starvation R-HSA-9711097 0.646242 0.190 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 0.649027 0.188 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.649027 0.188 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.649027 0.188 0 0
Pyrimidine biosynthesis R-HSA-500753 0.649027 0.188 0 0
Specification of the neural plate border R-HSA-9834899 0.649027 0.188 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 0.649027 0.188 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 0.649027 0.188 0 0
Rap1 signalling R-HSA-392517 0.649027 0.188 0 0
Regulation of signaling by CBL R-HSA-912631 0.649027 0.188 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 0.649027 0.188 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 0.649027 0.188 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.649408 0.187 0 0
Signaling by Insulin receptor R-HSA-74752 0.649408 0.187 0 0
TBC/RABGAPs R-HSA-8854214 0.651544 0.186 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.654299 0.184 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.656284 0.183 0 0
rRNA processing R-HSA-72312 0.659650 0.181 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.660985 0.180 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.661924 0.179 0 0
RMTs methylate histone arginines R-HSA-3214858 0.661924 0.179 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.664021 0.178 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.664021 0.178 0 0
Acyl chain remodelling of PI R-HSA-1482922 0.664021 0.178 0 0
Formation of definitive endoderm R-HSA-9823730 0.664021 0.178 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 0.664021 0.178 0 0
Pregnenolone biosynthesis R-HSA-196108 0.664021 0.178 0 0
Signal transduction by L1 R-HSA-445144 0.664021 0.178 0 0
Signaling by NODAL R-HSA-1181150 0.664021 0.178 0 0
Ribosome-associated quality control R-HSA-9948299 0.668365 0.175 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.668949 0.175 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.668949 0.175 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.671443 0.173 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.672055 0.173 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.672055 0.173 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.672055 0.173 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.672055 0.173 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.677532 0.169 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.677532 0.169 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 0.678375 0.169 0 0
Acyl chain remodelling of PG R-HSA-1482925 0.678375 0.169 0 0
Eukaryotic Translation Termination R-HSA-72764 0.678573 0.168 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.681939 0.166 0 0
Signaling by TGFBR3 R-HSA-9839373 0.681939 0.166 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.685579 0.164 0 0
DNA Repair R-HSA-73894 0.685783 0.164 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.685974 0.164 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.688068 0.162 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.688068 0.162 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 0.692117 0.160 0 0
Ribavirin ADME R-HSA-9755088 0.692117 0.160 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.692506 0.160 0 0
SARS-CoV Infections R-HSA-9679506 0.694105 0.159 0 0
Toll-like Receptor Cascades R-HSA-168898 0.695520 0.158 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.699309 0.155 0 0
Signaling by FGFR R-HSA-190236 0.699309 0.155 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.700392 0.155 0 0
Gluconeogenesis R-HSA-70263 0.700973 0.154 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.701220 0.154 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.702961 0.153 0 0
FGFR2 alternative splicing R-HSA-6803529 0.705273 0.152 0 0
Fructose metabolism R-HSA-5652084 0.705273 0.152 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 0.705273 0.152 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.706004 0.151 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.706426 0.151 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.706426 0.151 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.708815 0.149 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.712374 0.147 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 0.717867 0.144 0 0
Organic anion transport by SLCO transporters R-HSA-879518 0.717867 0.144 0 0
Carnitine shuttle R-HSA-200425 0.717867 0.144 0 0
Growth hormone receptor signaling R-HSA-982772 0.717867 0.144 0 0
Formation of the ureteric bud R-HSA-9830674 0.717867 0.144 0 0
Syndecan interactions R-HSA-3000170 0.717867 0.144 0 0
PI3K Cascade R-HSA-109704 0.719052 0.143 0 0
Azathioprine ADME R-HSA-9748787 0.719052 0.143 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.719052 0.143 0 0
Selenocysteine synthesis R-HSA-2408557 0.719067 0.143 0 0
RNA Polymerase I Transcription R-HSA-73864 0.723560 0.141 0 0
Meiotic recombination R-HSA-912446 0.727741 0.138 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.729871 0.137 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.729924 0.137 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.729924 0.137 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.729924 0.137 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 0.729924 0.137 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 0.729924 0.137 0 0
Viral mRNA Translation R-HSA-192823 0.731697 0.136 0 0
Orc1 removal from chromatin R-HSA-68949 0.736202 0.133 0 0
mRNA 3'-end processing R-HSA-72187 0.736202 0.133 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.736202 0.133 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.740850 0.130 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.741466 0.130 0 0
Tight junction interactions R-HSA-420029 0.741466 0.130 0 0
Formation of the nephric duct R-HSA-9830364 0.741466 0.130 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 0.741466 0.130 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.743897 0.128 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.743897 0.128 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.744437 0.128 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.751291 0.124 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.752451 0.124 0 0
MET activates PTK2 signaling R-HSA-8874081 0.752516 0.123 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.752516 0.123 0 0
Urea cycle R-HSA-70635 0.752516 0.123 0 0
Platelet homeostasis R-HSA-418346 0.755670 0.122 0 0
Death Receptor Signaling R-HSA-73887 0.759837 0.119 0 0
Paracetamol ADME R-HSA-9753281 0.760248 0.119 0 0
Reproduction R-HSA-1474165 0.762079 0.118 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.763094 0.117 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.763094 0.117 0 0
Packaging Of Telomere Ends R-HSA-171306 0.763094 0.117 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.763094 0.117 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.763094 0.117 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.763094 0.117 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.763094 0.117 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 0.763094 0.117 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.763094 0.117 0 0
Triglyceride biosynthesis R-HSA-75109 0.763094 0.117 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 0.763094 0.117 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.767831 0.115 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.770590 0.113 0 0
HIV elongation arrest and recovery R-HSA-167287 0.773220 0.112 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.773220 0.112 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.773220 0.112 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.773220 0.112 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.773220 0.112 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.773220 0.112 0 0
Synthesis of PA R-HSA-1483166 0.775204 0.111 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.782373 0.107 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.782373 0.107 0 0
Late endosomal microautophagy R-HSA-9615710 0.782914 0.106 0 0
Thyroxine biosynthesis R-HSA-209968 0.782914 0.106 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 0.782914 0.106 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 0.782914 0.106 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.782914 0.106 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 0.782914 0.106 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.782914 0.106 0 0
Developmental Cell Lineages R-HSA-9734767 0.788194 0.103 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.788482 0.103 0 0
Peroxisomal protein import R-HSA-9033241 0.789339 0.103 0 0
Metabolism of non-coding RNA R-HSA-194441 0.789339 0.103 0 0
snRNP Assembly R-HSA-191859 0.789339 0.103 0 0
Amino acid transport across the plasma membrane R-HSA-352230 0.789339 0.103 0 0
Triglyceride metabolism R-HSA-8979227 0.789339 0.103 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 0.792195 0.101 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.796109 0.099 0 0
Developmental Biology R-HSA-1266738 0.798509 0.098 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.798606 0.098 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.801079 0.096 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.801079 0.096 0 0
Cargo concentration in the ER R-HSA-5694530 0.801079 0.096 0 0
Molecules associated with elastic fibres R-HSA-2129379 0.801079 0.096 0 0
EGFR downregulation R-HSA-182971 0.801079 0.096 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.802685 0.095 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.802685 0.095 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.802685 0.095 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.803519 0.095 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.809072 0.092 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.809584 0.092 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 0.809584 0.092 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.813682 0.090 0 0
Parasite infection R-HSA-9664407 0.813682 0.090 0 0
Leishmania phagocytosis R-HSA-9664417 0.813682 0.090 0 0
SLC transporter disorders R-HSA-5619102 0.816223 0.088 0 0
L1CAM interactions R-HSA-373760 0.817678 0.087 0 0
Signaling by WNT R-HSA-195721 0.817710 0.087 0 0
Nuclear RNA decay R-HSA-9930044 0.817726 0.087 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.817726 0.087 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.817726 0.087 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 0.817726 0.087 0 0
Neddylation R-HSA-8951664 0.823994 0.084 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.825520 0.083 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.825520 0.083 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.825520 0.083 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.825520 0.083 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.825520 0.083 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.825520 0.083 0 0
Homology Directed Repair R-HSA-5693538 0.826643 0.083 0 0
Cellular response to hypoxia R-HSA-1234174 0.827142 0.082 0 0
Mitochondrial protein degradation R-HSA-9837999 0.831095 0.080 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.832981 0.079 0 0
eNOS activation R-HSA-203615 0.832981 0.079 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.832981 0.079 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.832981 0.079 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.832981 0.079 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.832981 0.079 0 0
Signaling by NOTCH2 R-HSA-1980145 0.832981 0.079 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.832981 0.079 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.832981 0.079 0 0
Signal amplification R-HSA-392518 0.832981 0.079 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.835850 0.078 0 0
Metabolism of RNA R-HSA-8953854 0.836050 0.078 0 0
SLC-mediated transport of amino acids R-HSA-9958863 0.838318 0.077 0 0
Kidney development R-HSA-9830369 0.838318 0.077 0 0
Nicotinate metabolism R-HSA-196807 0.838318 0.077 0 0
Chromosome Maintenance R-HSA-73886 0.839403 0.076 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.840124 0.076 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.840124 0.076 0 0
Regulation of Apoptosis R-HSA-169911 0.840124 0.076 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 0.840124 0.076 0 0
PERK regulates gene expression R-HSA-381042 0.840124 0.076 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.840127 0.076 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.843657 0.074 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.845016 0.073 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.846961 0.072 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.846961 0.072 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.846961 0.072 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.846961 0.072 0 0
Triglyceride catabolism R-HSA-163560 0.846961 0.072 0 0
Telomere Maintenance R-HSA-157579 0.849430 0.071 0 0
Voltage gated Potassium channels R-HSA-1296072 0.853507 0.069 0 0
Degradation of DVL R-HSA-4641258 0.853507 0.069 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.853507 0.069 0 0
Cleavage of the damaged purine R-HSA-110331 0.853507 0.069 0 0
NCAM1 interactions R-HSA-419037 0.853507 0.069 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.853507 0.069 0 0
SLC-mediated transport of organic cations R-HSA-549127 0.853507 0.069 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.853507 0.069 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.853735 0.069 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.853735 0.069 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.853735 0.069 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.853859 0.069 0 0
Hedgehog 'on' state R-HSA-5632684 0.858729 0.066 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.859773 0.066 0 0
Depurination R-HSA-73927 0.859773 0.066 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 0.859773 0.066 0 0
Purine salvage R-HSA-74217 0.859773 0.066 0 0
Elastic fibre formation R-HSA-1566948 0.859773 0.066 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.859773 0.066 0 0
Hedgehog 'off' state R-HSA-5610787 0.862022 0.064 0 0
Interleukin-1 family signaling R-HSA-446652 0.862688 0.064 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.863450 0.064 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.863450 0.064 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.865771 0.063 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.865771 0.063 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 0.865771 0.063 0 0
Protein localization R-HSA-9609507 0.865965 0.062 0 0
Interleukin-1 signaling R-HSA-9020702 0.866010 0.062 0 0
Ca2+ pathway R-HSA-4086398 0.868026 0.061 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.869895 0.061 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.869895 0.061 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.871513 0.060 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.871513 0.060 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.871513 0.060 0 0
HIV Transcription Elongation R-HSA-167169 0.871513 0.060 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.871513 0.060 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.871513 0.060 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.871513 0.060 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.871513 0.060 0 0
Attenuation phase R-HSA-3371568 0.871513 0.060 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.871513 0.060 0 0
Interleukin-2 family signaling R-HSA-451927 0.871513 0.060 0 0
Tryptophan catabolism R-HSA-71240 0.871513 0.060 0 0
Glycogen metabolism R-HSA-8982491 0.871513 0.060 0 0
PPARA activates gene expression R-HSA-1989781 0.872323 0.059 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.877010 0.057 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.877010 0.057 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.877010 0.057 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.877010 0.057 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.878423 0.056 0 0
HIV Life Cycle R-HSA-162587 0.878423 0.056 0 0
Phospholipid metabolism R-HSA-1483257 0.879725 0.056 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.882272 0.054 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.882272 0.054 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.882272 0.054 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.882272 0.054 0 0
Scavenging by Class A Receptors R-HSA-3000480 0.882272 0.054 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.882272 0.054 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.884955 0.053 0 0
Translation of Structural Proteins R-HSA-9694635 0.884955 0.053 0 0
Signaling by TGFB family members R-HSA-9006936 0.887107 0.052 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 0.887309 0.052 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.887309 0.052 0 0
PCP/CE pathway R-HSA-4086400 0.888861 0.051 0 0
Integrin cell surface interactions R-HSA-216083 0.888861 0.051 0 0
Defective pyroptosis R-HSA-9710421 0.892131 0.050 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.892131 0.050 0 0
Cilium Assembly R-HSA-5617833 0.892445 0.049 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.894409 0.048 0 0
Amine ligand-binding receptors R-HSA-375280 0.896747 0.047 0 0
Viral Infection Pathways R-HSA-9824446 0.897493 0.047 0 0
Selenoamino acid metabolism R-HSA-2408522 0.897855 0.047 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.900417 0.046 0 0
Integration of energy metabolism R-HSA-163685 0.900417 0.046 0 0
Nucleosome assembly R-HSA-774815 0.901166 0.045 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.901166 0.045 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.901166 0.045 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.901166 0.045 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.901166 0.045 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.905396 0.043 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.905396 0.043 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.905396 0.043 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 0.905396 0.043 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.905396 0.043 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.906610 0.043 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.909445 0.041 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.909445 0.041 0 0
Hemostasis R-HSA-109582 0.909465 0.041 0 0
Plasma lipoprotein remodeling R-HSA-8963899 0.913321 0.039 0 0
Metal ion SLC transporters R-HSA-425410 0.913321 0.039 0 0
DNA Damage Bypass R-HSA-73893 0.917031 0.038 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 0.917031 0.038 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.918863 0.037 0 0
Ub-specific processing proteases R-HSA-5689880 0.920923 0.036 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.921138 0.036 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.923982 0.034 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.923982 0.034 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.923982 0.034 0 0
The phototransduction cascade R-HSA-2514856 0.923982 0.034 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.927237 0.033 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.927237 0.033 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.927237 0.033 0 0
Keratinization R-HSA-6805567 0.928505 0.032 0 0
Downstream TCR signaling R-HSA-202424 0.929593 0.032 0 0
Neurotransmitter release cycle R-HSA-112310 0.929593 0.032 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 0.929593 0.032 0 0
Base Excision Repair R-HSA-73884 0.929593 0.032 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.930352 0.031 0 0
Nucleotide biosynthesis R-HSA-8956320 0.930352 0.031 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.930352 0.031 0 0
Translation initiation complex formation R-HSA-72649 0.933334 0.030 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.936745 0.028 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.938922 0.027 0 0
Metabolism of amine-derived hormones R-HSA-209776 0.938922 0.027 0 0
TNF signaling R-HSA-75893 0.938922 0.027 0 0
Host Interactions of HIV factors R-HSA-162909 0.939502 0.027 0 0
Dectin-2 family R-HSA-5621480 0.941537 0.026 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.944041 0.025 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.944041 0.025 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.945550 0.024 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.946438 0.024 0 0
Mitochondrial translation elongation R-HSA-5389840 0.947157 0.024 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.948124 0.023 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.948732 0.023 0 0
Glutathione conjugation R-HSA-156590 0.948732 0.023 0 0
Metabolism of polyamines R-HSA-351202 0.948732 0.023 0 0
Signaling by Retinoic Acid R-HSA-5362517 0.948732 0.023 0 0
Mitochondrial translation initiation R-HSA-5368286 0.950847 0.022 0 0
MAP kinase activation R-HSA-450294 0.950928 0.022 0 0
Nucleotide salvage R-HSA-8956321 0.950928 0.022 0 0
ABC-family proteins mediated transport R-HSA-382556 0.954290 0.020 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.955043 0.020 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.956969 0.019 0 0
HCMV Early Events R-HSA-9609690 0.957364 0.019 0 0
HIV Infection R-HSA-162906 0.958056 0.019 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.959026 0.018 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.960497 0.018 0 0
Metabolism of steroid hormones R-HSA-196071 0.962267 0.017 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.963289 0.016 0 0
Transcription of the HIV genome R-HSA-167172 0.963884 0.016 0 0
Regulated Necrosis R-HSA-5218859 0.963884 0.016 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.963884 0.016 0 0
G alpha (q) signalling events R-HSA-416476 0.964184 0.016 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.964926 0.016 0 0
Signaling by Hedgehog R-HSA-5358351 0.965048 0.015 0 0
Gene Silencing by RNA R-HSA-211000 0.965891 0.015 0 0
Interleukin-17 signaling R-HSA-448424 0.966913 0.015 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.967125 0.015 0 0
Mitochondrial translation termination R-HSA-5419276 0.968316 0.014 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.968316 0.014 0 0
ECM proteoglycans R-HSA-3000178 0.968331 0.014 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.968331 0.014 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.968331 0.014 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.969465 0.013 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.969465 0.013 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.969689 0.013 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.970363 0.013 0 0
Disease R-HSA-1643685 0.971202 0.013 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.972232 0.012 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 0.972232 0.012 0 0
ROS and RNS production in phagocytes R-HSA-1222556 0.972232 0.012 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.972676 0.012 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.975561 0.011 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.976455 0.010 0 0
ABC transporter disorders R-HSA-5619084 0.976697 0.010 0 0
SLC-mediated transport of organic anions R-HSA-9955298 0.976697 0.010 0 0
HCMV Infection R-HSA-9609646 0.977353 0.010 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 0.977696 0.010 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.977696 0.010 0 0
GPCR downstream signalling R-HSA-388396 0.978876 0.009 1 0
Amyloid fiber formation R-HSA-977225 0.979568 0.009 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.981283 0.008 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.982086 0.008 0 0
HCMV Late Events R-HSA-9610379 0.982089 0.008 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.984968 0.007 0 0
Signaling by GPCR R-HSA-372790 0.987056 0.006 1 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.987109 0.006 0 0
SLC-mediated transmembrane transport R-HSA-425407 0.987251 0.006 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.987352 0.006 0 0
Protein folding R-HSA-391251 0.988447 0.005 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.988447 0.005 0 0
tRNA processing R-HSA-72306 0.988923 0.005 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.988942 0.005 0 0
G alpha (s) signalling events R-HSA-418555 0.989301 0.005 0 0
Collagen formation R-HSA-1474290 0.989417 0.005 0 0
Leishmania infection R-HSA-9658195 0.990575 0.004 0 0
Parasitic Infection Pathways R-HSA-9824443 0.990575 0.004 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.990722 0.004 0 0
Potassium Channels R-HSA-1296071 0.990722 0.004 0 0
Mitochondrial translation R-HSA-5368287 0.991198 0.004 0 0
Regulation of insulin secretion R-HSA-422356 0.991502 0.004 0 0
Synthesis of bile acids and bile salts R-HSA-192105 0.991867 0.004 0 0
Drug ADME R-HSA-9748784 0.992474 0.003 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.993166 0.003 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.993275 0.003 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 0.993439 0.003 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 0.993750 0.003 0 0
Nucleotide Excision Repair R-HSA-5696398 0.994019 0.003 0 0
Translation R-HSA-72766 0.994288 0.002 0 0
Post-translational protein modification R-HSA-597592 0.994293 0.002 0 0
Infectious disease R-HSA-5663205 0.994755 0.002 0 0
Arachidonate metabolism R-HSA-2142753 0.995066 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 0.995198 0.002 0 0
Antimicrobial peptides R-HSA-6803157 0.995405 0.002 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 0.995577 0.002 0 0
G alpha (i) signalling events R-HSA-418594 0.995633 0.002 1 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.996470 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 0.996767 0.001 0 0
Bacterial Infection Pathways R-HSA-9824439 0.997214 0.001 0 0
Regulation of Complement cascade R-HSA-977606 0.997725 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 0.997913 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 0.997913 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.997917 0.001 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 0.998400 0.001 0 0
Diseases of glycosylation R-HSA-3781865 0.998649 0.001 0 0
Transport of small molecules R-HSA-382551 0.998827 0.001 0 0
Complement cascade R-HSA-166658 0.999209 0.000 0 0
Visual phototransduction R-HSA-2187338 0.999276 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 0.999365 0.000 0 0
Extracellular matrix organization R-HSA-1474244 0.999380 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 0.999534 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.999795 0.000 0 0
Metabolism of nucleotides R-HSA-15869 0.999839 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 0.999876 0.000 0 0
Sphingolipid metabolism R-HSA-428157 0.999936 0.000 0 0
Metabolism of steroids R-HSA-8957322 0.999965 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 0.999989 0.000 0 0
Metabolism of proteins R-HSA-392499 0.999991 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 0.999993 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 0.999998 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 0.999998 0.000 0 0
Fatty acid metabolism R-HSA-8978868 0.999999 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 0.999999 0.000 0 0
Diseases of metabolism R-HSA-5668914 0.999999 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000 0.000 0 0
Biological oxidations R-HSA-211859 1.000000 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.000000 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.551115e-16 15.256 0 0
Nervous system development R-HSA-9675108 1.665335e-15 14.778 0 0
Cellular responses to stimuli R-HSA-8953897 5.440093e-15 14.264 0 0
Axon guidance R-HSA-422475 7.438494e-15 14.129 0 0
Post NMDA receptor activation events R-HSA-438064 2.864375e-14 13.543 1 0
Cellular responses to stress R-HSA-2262752 3.808065e-14 13.419 0 0
Recycling pathway of L1 R-HSA-437239 7.249756e-14 13.140 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.515411e-14 13.070 0 0
L1CAM interactions R-HSA-373760 1.615375e-13 12.792 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.596501e-13 12.797 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.615685e-13 12.582 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.207701e-12 11.918 1 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.006684e-12 11.397 0 0
Aggrephagy R-HSA-9646399 4.148015e-12 11.382 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.566525e-12 11.183 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.559398e-12 11.122 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.129830e-12 11.090 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.103162e-11 10.957 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.063294e-11 10.973 0 0
PKR-mediated signaling R-HSA-9833482 6.330902e-11 10.199 0 0
Selective autophagy R-HSA-9663891 6.500067e-11 10.187 0 0
Gap junction trafficking R-HSA-190828 1.791826e-10 9.747 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.380185e-10 9.623 0 0
Cellular response to heat stress R-HSA-3371556 3.103617e-10 9.508 0 0
Gap junction assembly R-HSA-190861 4.667839e-10 9.331 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 6.102531e-10 9.214 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.077713e-10 9.216 0 0
Gap junction trafficking and regulation R-HSA-157858 7.039236e-10 9.152 0 0
Autophagy R-HSA-9612973 7.862827e-10 9.104 0 0
Mitotic Prometaphase R-HSA-68877 1.145339e-09 8.941 0 0
Kinesins R-HSA-983189 1.423753e-09 8.847 0 0
Macroautophagy R-HSA-1632852 1.791181e-09 8.747 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.063305e-09 8.514 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.211222e-09 8.376 0 0
Interleukin-12 signaling R-HSA-9020591 6.194563e-09 8.208 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.789287e-09 8.168 0 0
HSF1-dependent transactivation R-HSA-3371571 8.280760e-09 8.082 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.602156e-09 8.018 0 0
Cilium Assembly R-HSA-5617833 1.149017e-08 7.940 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.284881e-08 7.891 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.403396e-08 7.853 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.385217e-08 7.858 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.766550e-08 7.753 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.766550e-08 7.753 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.766550e-08 7.753 0 0
Signaling by RAS mutants R-HSA-6802949 1.766550e-08 7.753 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.945553e-08 7.711 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.238974e-08 7.650 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.552305e-08 7.593 0 0
Protein folding R-HSA-391251 2.560453e-08 7.592 0 0
G2/M Transition R-HSA-69275 2.736944e-08 7.563 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.355788e-08 7.474 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.732914e-08 7.428 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.816157e-08 7.418 0 0
Cell Cycle R-HSA-1640170 3.863674e-08 7.413 0 0
Interleukin-12 family signaling R-HSA-447115 4.930423e-08 7.307 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.497457e-08 7.260 0 0
Signal Transduction R-HSA-162582 9.623959e-08 7.017 1 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.077351e-07 6.968 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.216021e-07 6.915 0 0
Developmental Biology R-HSA-1266738 1.258434e-07 6.900 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.523861e-07 6.817 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.898866e-07 6.722 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.534947e-07 6.596 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.585740e-07 6.587 0 0
Cell Cycle, Mitotic R-HSA-69278 2.606487e-07 6.584 0 0
M Phase R-HSA-68886 3.309970e-07 6.480 0 0
Separation of Sister Chromatids R-HSA-2467813 4.191091e-07 6.378 0 0
Mitotic Anaphase R-HSA-68882 4.874017e-07 6.312 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.300018e-07 6.276 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.630881e-07 6.249 0 0
Membrane Trafficking R-HSA-199991 5.711617e-07 6.243 0 0
Apoptotic execution phase R-HSA-75153 7.640308e-07 6.117 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.904090e-07 6.004 0 0
Attenuation phase R-HSA-3371568 1.109613e-06 5.955 0 0
Intraflagellar transport R-HSA-5620924 1.136404e-06 5.944 0 0
MAP2K and MAPK activation R-HSA-5674135 1.696699e-06 5.770 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.939677e-06 5.712 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.117768e-06 5.674 0 0
Metabolism of RNA R-HSA-8953854 2.169201e-06 5.664 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.354883e-06 5.628 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.262369e-06 5.486 0 0
Signaling by VEGF R-HSA-194138 3.331173e-06 5.477 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.463404e-06 5.460 0 0
Transmission across Chemical Synapses R-HSA-112315 5.751331e-06 5.240 1 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.076686e-06 5.150 0 0
HCMV Early Events R-HSA-9609690 7.526989e-06 5.123 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.221012e-06 5.085 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.221012e-06 5.085 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 8.426776e-06 5.074 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 8.910279e-06 5.050 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.017557e-05 4.992 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.098282e-05 4.959 0 0
Interferon Signaling R-HSA-913531 1.267218e-05 4.897 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.409628e-05 4.851 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.409628e-05 4.851 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.529242e-05 4.816 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.529242e-05 4.816 0 0
HSF1 activation R-HSA-3371511 1.898449e-05 4.722 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.969398e-05 4.706 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.969398e-05 4.706 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.969398e-05 4.706 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.155688e-05 4.666 0 0
MHC class II antigen presentation R-HSA-2132295 3.006640e-05 4.522 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.406235e-05 4.468 0 0
Signaling by ROBO receptors R-HSA-376176 3.582898e-05 4.446 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.760978e-05 4.425 0 0
Apoptosis R-HSA-109581 3.766477e-05 4.424 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.226434e-05 4.374 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.041460e-05 4.393 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.933307e-05 4.307 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.361347e-05 4.271 0 0
Semaphorin interactions R-HSA-373755 6.356414e-05 4.197 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.555442e-05 4.183 0 0
Ephrin signaling R-HSA-3928664 6.555442e-05 4.183 0 0
MTOR signalling R-HSA-165159 6.617760e-05 4.179 0 0
Centrosome maturation R-HSA-380287 6.827697e-05 4.166 0 0
Vesicle-mediated transport R-HSA-5653656 7.258264e-05 4.139 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.613834e-05 4.065 0 0
HCMV Infection R-HSA-9609646 1.113493e-04 3.953 0 0
Cell-Cell communication R-HSA-1500931 1.274122e-04 3.895 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.296944e-04 3.887 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.414393e-04 3.849 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.430479e-04 3.845 0 0
EPH-Ephrin signaling R-HSA-2682334 1.433616e-04 3.844 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.734747e-04 3.761 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.759856e-04 3.755 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.784454e-04 3.748 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.843445e-04 3.734 0 0
Developmental Cell Lineages R-HSA-9734767 2.289482e-04 3.640 0 0
mRNA Splicing R-HSA-72172 2.806500e-04 3.552 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.642662e-04 3.578 0 0
Programmed Cell Death R-HSA-5357801 2.978873e-04 3.526 0 0
Peptide chain elongation R-HSA-156902 3.060385e-04 3.514 0 0
Smooth Muscle Contraction R-HSA-445355 3.219498e-04 3.492 0 0
Neurodegenerative Diseases R-HSA-8863678 3.277390e-04 3.484 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.277390e-04 3.484 0 0
Hedgehog 'off' state R-HSA-5610787 3.335754e-04 3.477 0 0
Striated Muscle Contraction R-HSA-390522 3.486335e-04 3.458 0 0
Signaling by Hippo R-HSA-2028269 3.870465e-04 3.412 0 0
Platelet degranulation R-HSA-114608 4.426848e-04 3.354 0 0
Signaling by Interleukins R-HSA-449147 4.472212e-04 3.349 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.847097e-04 3.315 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.879404e-04 3.312 0 0
Cell junction organization R-HSA-446728 4.917124e-04 3.308 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.738365e-04 3.241 0 0
Neuronal System R-HSA-112316 5.456132e-04 3.263 1 0
Hemostasis R-HSA-109582 5.932361e-04 3.227 0 0
Cellular response to starvation R-HSA-9711097 6.165783e-04 3.210 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.922413e-04 3.160 0 0
Signaling by ERBB2 R-HSA-1227986 7.372931e-04 3.132 0 0
Signal transduction by L1 R-HSA-445144 7.502797e-04 3.125 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.464290e-04 3.072 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.327035e-04 3.030 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.482289e-04 3.023 0 0
Muscle contraction R-HSA-397014 1.058177e-03 2.975 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.088661e-03 2.963 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.095223e-03 2.960 0 0
Signaling by Hedgehog R-HSA-5358351 1.099478e-03 2.959 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.378792e-03 2.861 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.312318e-03 2.882 0 0
mTORC1-mediated signalling R-HSA-166208 1.333530e-03 2.875 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.378792e-03 2.861 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.378792e-03 2.861 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.379510e-03 2.860 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.448572e-03 2.839 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.589617e-03 2.799 0 0
Syndecan interactions R-HSA-3000170 1.589617e-03 2.799 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.722256e-03 2.764 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.881461e-03 2.726 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.916424e-03 2.718 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.957472e-03 2.708 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.999882e-03 2.699 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.113429e-03 2.675 0 0
Eukaryotic Translation Termination R-HSA-72764 2.113429e-03 2.675 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.124601e-03 2.673 0 0
MAPK family signaling cascades R-HSA-5683057 2.199794e-03 2.658 0 0
Long-term potentiation R-HSA-9620244 2.212148e-03 2.655 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.212674e-03 2.655 0 0
Influenza Infection R-HSA-168255 2.228010e-03 2.652 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.382706e-03 2.623 1 1
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.591458e-03 2.586 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.908835e-03 2.536 0 0
Ribosome-associated quality control R-HSA-9948299 2.835503e-03 2.547 0 0
Immune System R-HSA-168256 2.570714e-03 2.590 0 0
Glycolysis R-HSA-70171 3.053120e-03 2.515 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.101603e-03 2.508 0 0
Diseases of programmed cell death R-HSA-9645723 3.137822e-03 2.503 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.233435e-03 2.490 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.234789e-03 2.490 0 0
Selenocysteine synthesis R-HSA-2408557 3.276511e-03 2.485 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.527045e-03 2.453 1 0
RAF/MAP kinase cascade R-HSA-5673001 3.533327e-03 2.452 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.561711e-03 2.448 0 0
Signaling by PTK6 R-HSA-8848021 3.561711e-03 2.448 0 0
Viral mRNA Translation R-HSA-192823 3.762923e-03 2.424 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.987425e-03 2.399 0 0
mRNA 3'-end processing R-HSA-72187 4.351105e-03 2.361 0 0
Viral Infection Pathways R-HSA-9824446 4.421764e-03 2.354 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.560826e-03 2.341 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.628052e-03 2.335 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.192744e-03 2.285 0 0
Translation initiation complex formation R-HSA-72649 5.265999e-03 2.279 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.436778e-03 2.265 0 0
Ca-dependent events R-HSA-111996 5.759405e-03 2.240 1 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.767043e-03 2.170 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.091887e-03 2.215 0 0
Integrin signaling R-HSA-354192 6.645574e-03 2.177 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.320983e-03 2.199 0 0
PTEN Regulation R-HSA-6807070 7.256166e-03 2.139 0 0
Regulation of CDH1 Function R-HSA-9764561 6.905031e-03 2.161 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.114081e-03 2.214 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.063986e-03 2.151 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.256166e-03 2.139 0 0
Manipulation of host energy metabolism R-HSA-9636667 7.285895e-03 2.138 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.285895e-03 2.138 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.534201e-03 2.123 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.706644e-03 2.113 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.950725e-03 2.100 0 0
RAF activation R-HSA-5673000 8.372649e-03 2.077 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 9.656271e-03 2.015 0 0
Gluconeogenesis R-HSA-70263 1.031250e-02 1.987 0 0
Co-stimulation by CD28 R-HSA-389356 1.031250e-02 1.987 0 0
Calmodulin induced events R-HSA-111933 1.040023e-02 1.983 1 0
CaM pathway R-HSA-111997 1.040023e-02 1.983 1 0
Response of endothelial cells to shear stress R-HSA-9860931 1.055122e-02 1.977 0 0
Prolonged ERK activation events R-HSA-169893 1.062467e-02 1.974 0 0
Rab regulation of trafficking R-HSA-9007101 1.066119e-02 1.972 0 0
Glucose metabolism R-HSA-70326 1.066119e-02 1.972 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.161982e-02 1.935 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.161982e-02 1.935 1 1
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.250271e-02 1.903 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.260055e-02 1.900 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.260055e-02 1.900 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.260055e-02 1.900 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.260055e-02 1.900 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.260055e-02 1.900 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.260055e-02 1.900 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.260055e-02 1.900 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.260055e-02 1.900 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.260055e-02 1.900 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.260055e-02 1.900 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.260055e-02 1.900 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.260055e-02 1.900 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.260055e-02 1.900 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.357932e-02 1.867 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.357932e-02 1.867 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.357932e-02 1.867 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.458048e-02 1.836 0 0
Lipophagy R-HSA-9613354 1.463138e-02 1.835 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.463138e-02 1.835 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.463138e-02 1.835 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.463138e-02 1.835 1 1
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.463138e-02 1.835 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.804354e-02 1.744 0 0
Rap1 signalling R-HSA-392517 1.935991e-02 1.713 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.930837e-02 1.714 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.767259e-02 1.753 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.767259e-02 1.753 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.686435e-02 1.773 0 0
Activation of BH3-only proteins R-HSA-114452 1.897801e-02 1.722 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.946832e-02 1.711 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.985836e-02 1.702 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.059769e-02 1.686 0 0
Trafficking of AMPA receptors R-HSA-399719 2.105039e-02 1.677 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.200564e-02 1.657 0 0
Nephrin family interactions R-HSA-373753 2.207199e-02 1.656 0 0
rRNA processing R-HSA-72312 2.236278e-02 1.650 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.277151e-02 1.643 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.389523e-02 1.622 0 0
snRNP Assembly R-HSA-191859 2.465509e-02 1.608 0 0
Metabolism of non-coding RNA R-HSA-194441 2.465509e-02 1.608 0 0
G-protein beta:gamma signalling R-HSA-397795 2.562461e-02 1.591 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.562461e-02 1.591 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.562461e-02 1.591 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.562461e-02 1.591 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.589049e-02 1.587 0 0
DAG and IP3 signaling R-HSA-1489509 2.589049e-02 1.587 1 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.591121e-02 1.587 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.641627e-02 1.578 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.683850e-02 1.571 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.683850e-02 1.571 0 0
MTF1 activates gene expression R-HSA-5660489 2.683850e-02 1.571 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.683850e-02 1.571 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.743489e-02 1.562 0 0
Translation R-HSA-72766 2.755790e-02 1.560 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.788865e-02 1.555 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.816134e-02 1.550 0 0
PLC beta mediated events R-HSA-112043 2.826130e-02 1.549 1 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.071042e-02 1.513 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.113340e-02 1.507 0 0
Signaling by ALK in cancer R-HSA-9700206 3.113340e-02 1.507 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.154454e-02 1.501 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.154454e-02 1.501 0 0
Neutrophil degranulation R-HSA-6798695 3.335798e-02 1.477 0 0
PERK regulates gene expression R-HSA-381042 3.360054e-02 1.474 0 0
Signalling to ERKs R-HSA-187687 3.360054e-02 1.474 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.515618e-02 1.454 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.554754e-02 1.449 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.554754e-02 1.449 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.554754e-02 1.449 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.573927e-02 1.447 0 0
Frs2-mediated activation R-HSA-170968 3.573927e-02 1.447 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.592692e-02 1.445 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.603122e-02 1.443 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.656529e-02 1.437 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.518502e-02 1.345 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.639949e-02 1.333 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.999407e-02 1.301 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.999407e-02 1.301 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.620486e-02 1.335 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 4.999407e-02 1.301 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.518502e-02 1.345 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.317371e-02 1.274 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.697861e-02 1.328 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.639949e-02 1.333 0 0
Protein methylation R-HSA-8876725 4.697861e-02 1.328 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.518502e-02 1.345 0 0
G-protein mediated events R-HSA-112040 4.117159e-02 1.385 1 0
Cell-cell junction organization R-HSA-421270 4.070760e-02 1.390 0 0
Adherens junctions interactions R-HSA-418990 4.715151e-02 1.327 0 0
ESR-mediated signaling R-HSA-8939211 4.715882e-02 1.326 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.120973e-02 1.385 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.518502e-02 1.345 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.886274e-02 1.311 0 0
Cell Cycle Checkpoints R-HSA-69620 4.965448e-02 1.304 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.886274e-02 1.311 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.518502e-02 1.345 0 0
Adaptive Immune System R-HSA-1280218 5.246848e-02 1.280 0 0
Regulation of TP53 Activity R-HSA-5633007 4.076275e-02 1.390 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.697861e-02 1.328 0 0
Selenoamino acid metabolism R-HSA-2408522 4.703559e-02 1.328 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.639949e-02 1.333 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.374777e-02 1.270 0 0
Potential therapeutics for SARS R-HSA-9679191 5.480008e-02 1.261 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.566013e-02 1.254 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.566013e-02 1.254 0 0
Nef and signal transduction R-HSA-164944 5.566013e-02 1.254 0 0
Opioid Signalling R-HSA-111885 5.675785e-02 1.246 1 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.675845e-02 1.246 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.973988e-02 1.224 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.973988e-02 1.224 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.045156e-02 1.219 0 0
Late endosomal microautophagy R-HSA-9615710 6.164494e-02 1.210 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.171567e-02 1.210 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.359049e-02 1.197 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.439700e-02 1.191 0 0
TBC/RABGAPs R-HSA-8854214 6.596310e-02 1.181 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.666625e-02 1.176 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.666625e-02 1.176 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.685353e-02 1.175 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.688791e-02 1.175 0 0
Disinhibition of SNARE formation R-HSA-114516 6.688791e-02 1.175 0 0
CHL1 interactions R-HSA-447041 6.688791e-02 1.175 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.688791e-02 1.175 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.688791e-02 1.175 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.688791e-02 1.175 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.394100e-02 1.131 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 7.394100e-02 1.131 0 0
GAB1 signalosome R-HSA-180292 7.394100e-02 1.131 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.859578e-02 1.105 0 0
Type I hemidesmosome assembly R-HSA-446107 7.878899e-02 1.104 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.878899e-02 1.104 0 0
Formation of annular gap junctions R-HSA-196025 7.878899e-02 1.104 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.878899e-02 1.104 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.878899e-02 1.104 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.878899e-02 1.104 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.959742e-02 1.099 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 8.053631e-02 1.094 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 8.053631e-02 1.094 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 8.053631e-02 1.094 0 0
Diseases of Telomere Maintenance R-HSA-9673013 8.053631e-02 1.094 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 8.053631e-02 1.094 0 0
TICAM1 deficiency - HSE R-HSA-5602566 8.053631e-02 1.094 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 8.053631e-02 1.094 0 0
Inhibition of PKR R-HSA-169131 8.053631e-02 1.094 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.074597e-02 1.093 0 0
Cellular Senescence R-HSA-2559583 8.107226e-02 1.091 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.155147e-02 1.089 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.155147e-02 1.089 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 8.378991e-02 1.077 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.445237e-02 1.073 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.945976e-02 1.048 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 8.948435e-02 1.048 0 0
Formation of definitive endoderm R-HSA-9823730 8.948435e-02 1.048 0 0
Protein hydroxylation R-HSA-9629569 8.948435e-02 1.048 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.948435e-02 1.048 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 1.183420e-01 0.927 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.183420e-01 0.927 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 1.183420e-01 0.927 0 0
TRAF3 deficiency - HSE R-HSA-5602571 1.183420e-01 0.927 0 0
ARMS-mediated activation R-HSA-170984 9.128919e-02 1.040 0 0
Gap junction degradation R-HSA-190873 9.128919e-02 1.040 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 9.128919e-02 1.040 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.043193e-01 0.982 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.043193e-01 0.982 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.178148e-01 0.929 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 1.317155e-01 0.880 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 9.772573e-02 1.010 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 9.772573e-02 1.010 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.062613e-01 0.974 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.062613e-01 0.974 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.985949e-02 1.046 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.985949e-02 1.046 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.985949e-02 1.046 0 0
Deadenylation of mRNA R-HSA-429947 1.334850e-01 0.875 0 0
Dual Incision in GG-NER R-HSA-5696400 9.613376e-02 1.017 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.613376e-02 1.017 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.092762e-01 0.961 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.161335e-01 0.935 0 0
Meiotic synapsis R-HSA-1221632 1.167085e-01 0.933 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.045235e-01 0.981 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.045235e-01 0.981 0 0
Signaling by ERBB4 R-HSA-1236394 1.343477e-01 0.872 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.317155e-01 0.880 0 0
Formation of apoptosome R-HSA-111458 1.043193e-01 0.982 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.241559e-01 0.906 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.621580e-02 1.017 0 0
Chromosome Maintenance R-HSA-73886 1.194778e-01 0.923 0 0
Mitotic Spindle Checkpoint R-HSA-69618 9.959956e-02 1.002 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.043193e-01 0.982 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.043193e-01 0.982 0 0
Regulation of CDH11 function R-HSA-9762292 1.043193e-01 0.982 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.062613e-01 0.974 0 0
Nuclear import of Rev protein R-HSA-180746 9.613376e-02 1.017 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.186015e-01 0.926 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.613376e-02 1.017 0 0
MET promotes cell motility R-HSA-8875878 1.231737e-01 0.909 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.026078e-01 0.989 0 0
G alpha (z) signalling events R-HSA-418597 1.285920e-01 0.891 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.183420e-01 0.927 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 1.183420e-01 0.927 0 0
Unwinding of DNA R-HSA-176974 9.128919e-02 1.040 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.317155e-01 0.880 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.334850e-01 0.875 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.334850e-01 0.875 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 9.128919e-02 1.040 0 0
HDACs deacetylate histones R-HSA-3214815 1.285920e-01 0.891 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.303910e-01 0.885 0 0
Host Interactions of HIV factors R-HSA-162909 1.312492e-01 0.882 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.072654e-01 0.970 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.334850e-01 0.875 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.043193e-01 0.982 0 0
Activation of RAC1 R-HSA-428540 1.317155e-01 0.880 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.241559e-01 0.906 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 1.303910e-01 0.885 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.186015e-01 0.926 0 0
Chromatin modifying enzymes R-HSA-3247509 1.208218e-01 0.918 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 9.128919e-02 1.040 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.985949e-02 1.046 0 0
Mitotic Prophase R-HSA-68875 1.156870e-01 0.937 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.185188e-01 0.926 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.178148e-01 0.929 0 0
Signaling by EGFR R-HSA-177929 1.347327e-01 0.871 0 0
IRE1alpha activates chaperones R-HSA-381070 1.364979e-01 0.865 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.377788e-01 0.861 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.377788e-01 0.861 0 0
Disease R-HSA-1643685 1.411418e-01 0.850 0 0
Infectious disease R-HSA-5663205 1.412211e-01 0.850 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.430484e-01 0.845 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.459655e-01 0.836 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.459655e-01 0.836 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.459655e-01 0.836 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.459655e-01 0.836 0 0
G2/M Checkpoints R-HSA-69481 1.478526e-01 0.830 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.528308e-01 0.816 0 0
Myogenesis R-HSA-525793 1.528308e-01 0.816 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.530405e-01 0.815 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.539102e-01 0.813 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.545953e-01 0.811 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 1.545953e-01 0.811 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 1.545953e-01 0.811 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 1.545953e-01 0.811 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.567815e-01 0.805 0 0
Cellular response to chemical stress R-HSA-9711123 1.602360e-01 0.795 0 0
Formation of axial mesoderm R-HSA-9796292 1.605126e-01 0.794 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.605126e-01 0.794 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.605126e-01 0.794 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.605424e-01 0.794 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.609008e-01 0.793 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 1.628172e-01 0.788 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.628172e-01 0.788 0 0
S Phase R-HSA-69242 1.652781e-01 0.782 0 0
Chromatin organization R-HSA-4839726 1.662818e-01 0.779 0 0
Defective pyroptosis R-HSA-9710421 1.689051e-01 0.772 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.726654e-01 0.763 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.729924e-01 0.762 0 0
Regulation of KIT signaling R-HSA-1433559 1.753084e-01 0.756 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.753084e-01 0.756 0 0
Gene expression (Transcription) R-HSA-74160 1.755386e-01 0.756 0 0
RMTs methylate histone arginines R-HSA-3214858 1.770462e-01 0.752 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 1.825736e-01 0.739 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.833415e-01 0.737 0 0
SARS-CoV Infections R-HSA-9679506 1.835480e-01 0.736 0 0
Nucleosome assembly R-HSA-774815 1.853173e-01 0.732 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.853173e-01 0.732 0 0
MET interacts with TNS proteins R-HSA-8875513 1.893601e-01 0.723 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.903079e-01 0.721 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.903079e-01 0.721 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.903079e-01 0.721 0 0
p75NTR signals via NF-kB R-HSA-193639 1.903079e-01 0.721 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.226973e-01 0.652 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.226973e-01 0.652 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.226973e-01 0.652 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.226973e-01 0.652 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.226973e-01 0.652 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.226973e-01 0.652 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.226973e-01 0.652 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.546655e-01 0.594 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.546655e-01 0.594 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.546655e-01 0.594 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.546655e-01 0.594 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.853208e-01 0.545 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.853208e-01 0.545 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.853208e-01 0.545 0 0
Signaling by RNF43 mutants R-HSA-5340588 2.853208e-01 0.545 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.147170e-01 0.502 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.147170e-01 0.502 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.147170e-01 0.502 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.429058e-01 0.465 0 0
Regulation of PTEN localization R-HSA-8948747 3.429058e-01 0.465 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.429058e-01 0.465 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.429058e-01 0.465 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.429058e-01 0.465 0 0
Recycling of eIF2:GDP R-HSA-72731 3.429058e-01 0.465 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.429058e-01 0.465 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.207547e-01 0.656 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.207547e-01 0.656 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.361277e-01 0.627 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.699368e-01 0.432 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.699368e-01 0.432 0 0
phospho-PLA2 pathway R-HSA-111995 3.699368e-01 0.432 0 0
MET receptor recycling R-HSA-8875656 3.699368e-01 0.432 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.699368e-01 0.432 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.699368e-01 0.432 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.938497e-01 0.713 0 0
Regulation of signaling by CBL R-HSA-912631 2.670074e-01 0.573 0 0
EGFR downregulation R-HSA-182971 2.045027e-01 0.689 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.045027e-01 0.689 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.045027e-01 0.689 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.261860e-01 0.646 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.978746e-01 0.526 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.594499e-01 0.586 0 0
Dual incision in TC-NER R-HSA-6782135 3.014380e-01 0.521 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.098196e-01 0.509 0 0
Nucleotide Excision Repair R-HSA-5696398 2.244414e-01 0.649 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.324405e-01 0.634 0 0
Extension of Telomeres R-HSA-180786 3.107894e-01 0.508 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.387732e-01 0.470 0 0
Polo-like kinase mediated events R-HSA-156711 2.515554e-01 0.599 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.546655e-01 0.594 0 0
Activation of AKT2 R-HSA-165158 2.546655e-01 0.594 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.207547e-01 0.656 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.515554e-01 0.599 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.737658e-01 0.427 0 0
Tight junction interactions R-HSA-420029 3.737658e-01 0.427 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.464834e-01 0.460 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 2.546655e-01 0.594 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.853208e-01 0.545 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 3.699368e-01 0.432 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.824557e-01 0.549 0 0
DNA strand elongation R-HSA-69190 2.152861e-01 0.667 0 0
Intra-Golgi traffic R-HSA-6811438 3.387732e-01 0.470 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.675128e-01 0.573 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.824557e-01 0.549 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.588112e-01 0.445 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.437275e-01 0.464 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.478181e-01 0.606 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.261860e-01 0.646 0 0
G0 and Early G1 R-HSA-1538133 2.152861e-01 0.667 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.779699e-01 0.556 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.853208e-01 0.545 0 0
PDE3B signalling R-HSA-165160 2.853208e-01 0.545 0 0
PKB-mediated events R-HSA-109703 2.853208e-01 0.545 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.054696e-01 0.687 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.429058e-01 0.465 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.429058e-01 0.465 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.361277e-01 0.627 0 0
FGFR1b ligand binding and activation R-HSA-190370 3.699368e-01 0.432 0 0
Apoptotic factor-mediated response R-HSA-111471 2.515554e-01 0.599 0 0
Meiosis R-HSA-1500620 1.995844e-01 0.700 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.737658e-01 0.427 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.160182e-01 0.500 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.160182e-01 0.500 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.501367e-01 0.456 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.840615e-01 0.416 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.606021e-01 0.443 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.007717e-01 0.697 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.387732e-01 0.470 0 0
Signaling by WNT R-HSA-195721 3.602940e-01 0.443 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.699368e-01 0.432 0 0
Adrenoceptors R-HSA-390696 3.699368e-01 0.432 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.978746e-01 0.526 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.932078e-01 0.714 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.371887e-01 0.625 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 2.932928e-01 0.533 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.285312e-01 0.483 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.546655e-01 0.594 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.160182e-01 0.500 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.160182e-01 0.500 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.226973e-01 0.652 0 0
NADE modulates death signalling R-HSA-205025 2.226973e-01 0.652 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.546655e-01 0.594 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.147170e-01 0.502 0 0
LDL remodeling R-HSA-8964041 3.429058e-01 0.465 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.699368e-01 0.432 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.699368e-01 0.432 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.644284e-01 0.578 0 0
Laminin interactions R-HSA-3000157 3.737658e-01 0.427 0 0
HATs acetylate histones R-HSA-3214847 3.170817e-01 0.499 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.537228e-01 0.451 0 0
Formation of the cornified envelope R-HSA-6809371 3.603777e-01 0.443 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.737658e-01 0.427 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.218356e-01 0.654 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.840615e-01 0.416 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.848961e-01 0.545 0 0
Molecules associated with elastic fibres R-HSA-2129379 2.045027e-01 0.689 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.737658e-01 0.427 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.737658e-01 0.427 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.207547e-01 0.656 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.261860e-01 0.646 0 0
tRNA processing in the nucleus R-HSA-6784531 3.389807e-01 0.470 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.025806e-01 0.693 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.389807e-01 0.470 0 0
Signaling by MET R-HSA-6806834 3.115023e-01 0.507 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.125412e-01 0.673 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.546655e-01 0.594 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.546655e-01 0.594 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.853208e-01 0.545 0 0
CREB phosphorylation R-HSA-199920 3.147170e-01 0.502 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.273971e-01 0.485 0 0
Signaling by NOTCH4 R-HSA-9013694 2.634476e-01 0.579 0 0
PCP/CE pathway R-HSA-4086400 2.953239e-01 0.530 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.501367e-01 0.456 0 0
Extracellular matrix organization R-HSA-1474244 3.093397e-01 0.510 0 0
Elastic fibre formation R-HSA-1566948 2.932928e-01 0.533 0 0
Generation of second messenger molecules R-HSA-202433 3.160182e-01 0.500 0 0
Reproduction R-HSA-1474165 2.734101e-01 0.563 0 0
Signaling by TGFB family members R-HSA-9006936 3.338411e-01 0.476 0 0
The NLRP3 inflammasome R-HSA-844456 2.670074e-01 0.573 0 0
Mitochondrial biogenesis R-HSA-1592230 3.135387e-01 0.504 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.371887e-01 0.625 0 0
Neurexins and neuroligins R-HSA-6794361 2.462537e-01 0.609 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.853208e-01 0.545 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.853208e-01 0.545 0 0
VLDL assembly R-HSA-8866423 3.147170e-01 0.502 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.054696e-01 0.687 0 0
Synthesis of PG R-HSA-1483148 2.207547e-01 0.656 0 0
Basigin interactions R-HSA-210991 2.978746e-01 0.526 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.932928e-01 0.533 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.558331e-01 0.592 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.196369e-01 0.495 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.515554e-01 0.599 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.108946e-01 0.676 0 0
RNA Polymerase II Transcription R-HSA-73857 3.263088e-01 0.486 0 0
Asparagine N-linked glycosylation R-HSA-446203 3.166938e-01 0.499 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.771364e-01 0.557 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.429058e-01 0.465 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.828410e-01 0.548 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.462537e-01 0.609 0 0
Netrin-1 signaling R-HSA-373752 3.727895e-01 0.429 0 0
Ion transport by P-type ATPases R-HSA-936837 3.578294e-01 0.446 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.978746e-01 0.526 0 0
Specification of primordial germ cells R-HSA-9827857 2.361277e-01 0.627 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.285312e-01 0.483 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.437275e-01 0.464 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.614784e-01 0.442 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.921197e-01 0.534 0 0
FLT3 Signaling R-HSA-9607240 3.273971e-01 0.485 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 2.828410e-01 0.548 0 0
Interleukin-23 signaling R-HSA-9020933 3.699368e-01 0.432 0 0
Response to metal ions R-HSA-5660526 2.207547e-01 0.656 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.125412e-01 0.673 0 0
Ion homeostasis R-HSA-5578775 2.828410e-01 0.548 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.830388e-01 0.417 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.273971e-01 0.485 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.007471e-01 0.522 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.046466e-01 0.516 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.885765e-01 0.411 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.885765e-01 0.411 0 0
Signaling by TGFBR3 R-HSA-9839373 3.952862e-01 0.403 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.952862e-01 0.403 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.954563e-01 0.403 0 0
ALK mutants bind TKIs R-HSA-9700645 3.958573e-01 0.402 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.958573e-01 0.402 0 0
Calcineurin activates NFAT R-HSA-2025928 3.958573e-01 0.402 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.958573e-01 0.402 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.958573e-01 0.402 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.958573e-01 0.402 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.958573e-01 0.402 0 0
Signaling by NTRKs R-HSA-166520 3.965878e-01 0.402 0 0
TCR signaling R-HSA-202403 4.054339e-01 0.392 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.064562e-01 0.391 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.175641e-01 0.379 0 0
NGF-stimulated transcription R-HSA-9031628 4.175641e-01 0.379 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 4.177136e-01 0.379 0 0
Telomere Extension By Telomerase R-HSA-171319 4.177136e-01 0.379 0 0
Inflammasomes R-HSA-622312 4.177136e-01 0.379 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.207130e-01 0.376 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.207130e-01 0.376 0 0
Binding and entry of HIV virion R-HSA-173107 4.207130e-01 0.376 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.207130e-01 0.376 0 0
2-LTR circle formation R-HSA-164843 4.207130e-01 0.376 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.207130e-01 0.376 0 0
Pexophagy R-HSA-9664873 4.207130e-01 0.376 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.207130e-01 0.376 0 0
DNA Damage Bypass R-HSA-73893 4.286032e-01 0.368 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.320171e-01 0.364 0 0
Platelet calcium homeostasis R-HSA-418360 4.320171e-01 0.364 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.320171e-01 0.364 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.327184e-01 0.364 0 0
Death Receptor Signaling R-HSA-73887 4.342814e-01 0.362 0 0
Co-inhibition by PD-1 R-HSA-389948 4.382506e-01 0.358 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.418897e-01 0.355 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.419422e-01 0.355 0 0
Ca2+ pathway R-HSA-4086398 4.419422e-01 0.355 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.419422e-01 0.355 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 4.422162e-01 0.354 0 0
vRNP Assembly R-HSA-192905 4.445475e-01 0.352 0 0
Chylomicron assembly R-HSA-8963888 4.445475e-01 0.352 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.445475e-01 0.352 0 0
Bicarbonate transporters R-HSA-425381 4.445475e-01 0.352 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.445475e-01 0.352 0 0
PECAM1 interactions R-HSA-210990 4.445475e-01 0.352 0 0
Suppression of apoptosis R-HSA-9635465 4.445475e-01 0.352 0 0
Interleukin-2 signaling R-HSA-9020558 4.445475e-01 0.352 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.445475e-01 0.352 0 0
Activation of the pre-replicative complex R-HSA-68962 4.461307e-01 0.351 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 4.461307e-01 0.351 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 4.461307e-01 0.351 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.581142e-01 0.339 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.600457e-01 0.337 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.602505e-01 0.337 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.612439e-01 0.336 0 0
Orc1 removal from chromatin R-HSA-68949 4.612439e-01 0.336 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.616198e-01 0.336 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.674028e-01 0.330 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.674028e-01 0.330 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.674028e-01 0.330 0 0
Integration of provirus R-HSA-162592 4.674028e-01 0.330 0 0
NF-kB is activated and signals survival R-HSA-209560 4.674028e-01 0.330 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.674028e-01 0.330 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.674028e-01 0.330 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.682910e-01 0.329 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.693273e-01 0.329 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.719462e-01 0.326 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.719462e-01 0.326 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.719462e-01 0.326 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.737546e-01 0.324 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.737546e-01 0.324 0 0
Signaling by WNT in cancer R-HSA-4791275 4.737546e-01 0.324 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.745474e-01 0.324 0 0
Telomere Maintenance R-HSA-157579 4.746417e-01 0.324 0 0
Regulation of insulin secretion R-HSA-422356 4.825872e-01 0.316 0 0
Nuclear RNA decay R-HSA-9930044 4.872508e-01 0.312 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.872508e-01 0.312 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.872508e-01 0.312 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.872508e-01 0.312 0 0
Integrin cell surface interactions R-HSA-216083 4.873083e-01 0.312 0 0
RNA Polymerase I Transcription R-HSA-73864 4.873083e-01 0.312 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.893189e-01 0.310 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.893189e-01 0.310 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.893189e-01 0.310 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.893189e-01 0.310 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.893189e-01 0.310 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.893189e-01 0.310 0 0
Repression of WNT target genes R-HSA-4641265 4.893189e-01 0.310 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.893189e-01 0.310 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 4.893189e-01 0.310 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 4.893189e-01 0.310 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.893189e-01 0.310 0 0
Polymerase switching R-HSA-69091 4.893189e-01 0.310 0 0
Leading Strand Synthesis R-HSA-69109 4.893189e-01 0.310 0 0
Pervasive developmental disorders R-HSA-9005895 4.893189e-01 0.310 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.893189e-01 0.310 0 0
Disorders of Nervous System Development R-HSA-9697154 4.893189e-01 0.310 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.893189e-01 0.310 0 0
OAS antiviral response R-HSA-8983711 4.893189e-01 0.310 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.904911e-01 0.309 0 0
Sensory processing of sound R-HSA-9659379 4.962057e-01 0.304 0 0
Acyl chain remodelling of PC R-HSA-1482788 5.005287e-01 0.301 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.005287e-01 0.301 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.034491e-01 0.298 0 0
TNF signaling R-HSA-75893 5.034491e-01 0.298 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.061643e-01 0.296 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.078452e-01 0.294 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.103345e-01 0.292 0 0
FGFR1c ligand binding and activation R-HSA-190373 5.103345e-01 0.292 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.103345e-01 0.292 0 0
Interleukin-6 signaling R-HSA-1059683 5.103345e-01 0.292 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.135833e-01 0.289 0 0
Signal amplification R-HSA-392518 5.135833e-01 0.289 0 0
eNOS activation R-HSA-203615 5.135833e-01 0.289 0 0
Mitophagy R-HSA-5205647 5.135833e-01 0.289 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.135833e-01 0.289 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.135833e-01 0.289 0 0
Synthesis of PA R-HSA-1483166 5.137341e-01 0.289 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.137988e-01 0.289 0 0
PI Metabolism R-HSA-1483255 5.139291e-01 0.289 0 0
Metabolism of proteins R-HSA-392499 5.169051e-01 0.287 0 0
Generic Transcription Pathway R-HSA-212436 5.206743e-01 0.283 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.239046e-01 0.281 0 0
Acyl chain remodelling of PE R-HSA-1482839 5.264106e-01 0.279 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.264106e-01 0.279 0 0
Removal of the Flap Intermediate R-HSA-69166 5.304865e-01 0.275 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.304865e-01 0.275 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.304865e-01 0.275 0 0
Hydrolysis of LPC R-HSA-1483115 5.304865e-01 0.275 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.304865e-01 0.275 0 0
Prolactin receptor signaling R-HSA-1170546 5.304865e-01 0.275 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.304865e-01 0.275 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.304865e-01 0.275 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.304865e-01 0.275 0 0
Glycerophospholipid catabolism R-HSA-6814848 5.304865e-01 0.275 0 0
Malate-aspartate shuttle R-HSA-9856872 5.304865e-01 0.275 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.304865e-01 0.275 0 0
Signal regulatory protein family interactions R-HSA-391160 5.304865e-01 0.275 0 0
Acyl chain remodeling of CL R-HSA-1482798 5.304865e-01 0.275 0 0
Zinc transporters R-HSA-435354 5.304865e-01 0.275 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.336540e-01 0.273 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.339572e-01 0.272 0 0
Regulation of beta-cell development R-HSA-186712 5.339572e-01 0.272 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.390071e-01 0.268 0 0
FLT3 signaling in disease R-HSA-9682385 5.390071e-01 0.268 0 0
RAB geranylgeranylation R-HSA-8873719 5.438887e-01 0.264 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.481004e-01 0.261 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.481004e-01 0.261 0 0
Erythropoietin activates RAS R-HSA-9027284 5.498103e-01 0.260 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.498103e-01 0.260 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.498103e-01 0.260 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.498103e-01 0.260 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.498103e-01 0.260 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.498103e-01 0.260 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.498103e-01 0.260 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.498103e-01 0.260 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.498103e-01 0.260 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.498103e-01 0.260 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.498103e-01 0.260 0 0
p38MAPK events R-HSA-171007 5.498103e-01 0.260 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.498103e-01 0.260 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.498103e-01 0.260 0 0
Other semaphorin interactions R-HSA-416700 5.498103e-01 0.260 0 0
DCC mediated attractive signaling R-HSA-418885 5.498103e-01 0.260 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.536964e-01 0.257 0 0
MAP kinase activation R-HSA-450294 5.536964e-01 0.257 0 0
Synthesis of DNA R-HSA-69239 5.593814e-01 0.252 0 0
Phosphorylation of the APC/C R-HSA-176412 5.683400e-01 0.245 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.683400e-01 0.245 0 0
Negative regulation of FLT3 R-HSA-9706369 5.683400e-01 0.245 0 0
Regulation of BACH1 activity R-HSA-9708530 5.683400e-01 0.245 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.683400e-01 0.245 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.683400e-01 0.245 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.729296e-01 0.242 0 0
Pyruvate metabolism R-HSA-70268 5.729770e-01 0.242 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.753880e-01 0.240 0 0
Pentose phosphate pathway R-HSA-71336 5.753880e-01 0.240 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.774512e-01 0.238 0 0
Adipogenesis R-HSA-9843745 5.822221e-01 0.235 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.861080e-01 0.232 0 0
Fibronectin matrix formation R-HSA-1566977 5.861080e-01 0.232 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 5.861080e-01 0.232 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.861080e-01 0.232 0 0
tRNA modification in the mitochondrion R-HSA-6787450 5.861080e-01 0.232 0 0
Disorders of Developmental Biology R-HSA-9675151 5.861080e-01 0.232 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.870401e-01 0.231 0 0
Diseases of Immune System R-HSA-5260271 5.870401e-01 0.231 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.870401e-01 0.231 0 0
HIV Infection R-HSA-162906 5.885745e-01 0.230 0 0
Post-translational protein modification R-HSA-597592 5.945533e-01 0.226 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.984536e-01 0.223 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.984536e-01 0.223 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 5.984536e-01 0.223 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.984536e-01 0.223 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.984536e-01 0.223 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.031457e-01 0.220 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.031457e-01 0.220 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.031457e-01 0.220 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.031457e-01 0.220 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.031457e-01 0.220 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.031457e-01 0.220 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.031457e-01 0.220 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.095817e-01 0.215 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.096282e-01 0.215 0 0
DNA Double Strand Break Response R-HSA-5693606 6.098110e-01 0.215 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.194831e-01 0.208 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.194831e-01 0.208 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.194831e-01 0.208 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.194831e-01 0.208 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.194831e-01 0.208 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.194831e-01 0.208 0 0
Platelet sensitization by LDL R-HSA-432142 6.194831e-01 0.208 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.194831e-01 0.208 0 0
Mismatch Repair R-HSA-5358508 6.194831e-01 0.208 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.194831e-01 0.208 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.194831e-01 0.208 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.205644e-01 0.207 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.205644e-01 0.207 0 0
Depyrimidination R-HSA-73928 6.205644e-01 0.207 0 0
Integration of energy metabolism R-HSA-163685 6.206581e-01 0.207 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.278887e-01 0.202 0 0
Signaling by SCF-KIT R-HSA-1433557 6.312627e-01 0.200 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.351488e-01 0.197 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.351488e-01 0.197 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.351488e-01 0.197 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.351488e-01 0.197 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.351488e-01 0.197 0 0
Specification of the neural plate border R-HSA-9834899 6.351488e-01 0.197 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 6.351488e-01 0.197 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.351488e-01 0.197 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.351488e-01 0.197 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.351488e-01 0.197 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.351488e-01 0.197 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.353551e-01 0.197 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.360383e-01 0.197 0 0
Interleukin-17 signaling R-HSA-448424 6.360383e-01 0.197 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.360383e-01 0.197 0 0
ECM proteoglycans R-HSA-3000178 6.445025e-01 0.191 0 0
Homology Directed Repair R-HSA-5693538 6.498628e-01 0.187 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.501705e-01 0.187 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.501705e-01 0.187 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.501705e-01 0.187 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.501705e-01 0.187 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.501705e-01 0.187 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.501705e-01 0.187 0 0
Negative regulation of MET activity R-HSA-6807004 6.501705e-01 0.187 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.501705e-01 0.187 0 0
Acyl chain remodelling of PI R-HSA-1482922 6.501705e-01 0.187 0 0
Creatine metabolism R-HSA-71288 6.501705e-01 0.187 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.501705e-01 0.187 0 0
Signaling by NOTCH R-HSA-157118 6.518843e-01 0.186 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.519505e-01 0.186 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.519505e-01 0.186 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.528267e-01 0.185 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.528267e-01 0.185 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.619429e-01 0.179 0 0
Regulation of pyruvate metabolism R-HSA-9861718 6.619429e-01 0.179 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.619429e-01 0.179 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.619429e-01 0.179 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.619429e-01 0.179 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.619429e-01 0.179 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.645746e-01 0.177 0 0
G-protein activation R-HSA-202040 6.645746e-01 0.177 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 6.645746e-01 0.177 0 0
Lagging Strand Synthesis R-HSA-69186 6.645746e-01 0.177 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.645746e-01 0.177 0 0
Abacavir metabolism R-HSA-2161541 6.645746e-01 0.177 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.645746e-01 0.177 0 0
Acyl chain remodelling of PG R-HSA-1482925 6.645746e-01 0.177 0 0
Signalling to RAS R-HSA-167044 6.645746e-01 0.177 0 0
Signaling by FGFR in disease R-HSA-1226099 6.690540e-01 0.175 0 0
FOXO-mediated transcription R-HSA-9614085 6.780816e-01 0.169 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.783865e-01 0.169 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.783865e-01 0.169 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.783865e-01 0.169 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.783865e-01 0.169 0 0
Ribavirin ADME R-HSA-9755088 6.783865e-01 0.169 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.783865e-01 0.169 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.783865e-01 0.169 0 0
tRNA processing R-HSA-72306 6.799380e-01 0.168 0 0
GPER1 signaling R-HSA-9634597 6.812344e-01 0.167 0 0
Plasma lipoprotein remodeling R-HSA-8963899 6.812344e-01 0.167 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.813507e-01 0.167 0 0
UCH proteinases R-HSA-5689603 6.847196e-01 0.164 0 0
Signaling by NOTCH1 R-HSA-1980143 6.847196e-01 0.164 0 0
Degradation of CDH1 R-HSA-9766229 6.905379e-01 0.161 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.905379e-01 0.161 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.916304e-01 0.160 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.916304e-01 0.160 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.916304e-01 0.160 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.916304e-01 0.160 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 6.916304e-01 0.160 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 6.916304e-01 0.160 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.916304e-01 0.160 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.916304e-01 0.160 0 0
G1/S Transition R-HSA-69206 6.993074e-01 0.155 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.996167e-01 0.155 0 0
G alpha (12/13) signalling events R-HSA-416482 6.998252e-01 0.155 0 0
Biosynthesis of maresins R-HSA-9018682 7.043297e-01 0.152 0 0
Formation of the ureteric bud R-HSA-9830674 7.043297e-01 0.152 0 0
Carnitine shuttle R-HSA-200425 7.043297e-01 0.152 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.084734e-01 0.150 0 0
The phototransduction cascade R-HSA-2514856 7.084734e-01 0.150 0 0
Innate Immune System R-HSA-168249 7.143562e-01 0.146 0 0
CYP2E1 reactions R-HSA-211999 7.165068e-01 0.145 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.165068e-01 0.145 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.165068e-01 0.145 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.165068e-01 0.145 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.165068e-01 0.145 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 7.165068e-01 0.145 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.165068e-01 0.145 0 0
Complex III assembly R-HSA-9865881 7.165068e-01 0.145 0 0
Interleukin-6 family signaling R-HSA-6783589 7.165068e-01 0.145 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.171108e-01 0.144 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.171108e-01 0.144 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.171108e-01 0.144 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.171961e-01 0.144 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.171961e-01 0.144 0 0
DNA Replication R-HSA-69306 7.229196e-01 0.141 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.233626e-01 0.141 0 0
DNA Repair R-HSA-73894 7.244883e-01 0.140 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.255322e-01 0.139 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.255322e-01 0.139 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.255322e-01 0.139 0 0
Nucleotide biosynthesis R-HSA-8956320 7.255322e-01 0.139 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.279911e-01 0.138 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.281831e-01 0.138 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.281831e-01 0.138 0 0
G protein gated Potassium channels R-HSA-1296059 7.281831e-01 0.138 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.281831e-01 0.138 0 0
TGFBR3 expression R-HSA-9839394 7.281831e-01 0.138 0 0
Interleukin-7 signaling R-HSA-1266695 7.281831e-01 0.138 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.281831e-01 0.138 0 0
HDMs demethylate histones R-HSA-3214842 7.281831e-01 0.138 0 0
Formation of the nephric duct R-HSA-9830364 7.281831e-01 0.138 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.281831e-01 0.138 0 0
Platelet homeostasis R-HSA-418346 7.294288e-01 0.137 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.337405e-01 0.134 0 0
Gene Silencing by RNA R-HSA-211000 7.353951e-01 0.133 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.393792e-01 0.131 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.393792e-01 0.131 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.393792e-01 0.131 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.393792e-01 0.131 0 0
MET activates PTK2 signaling R-HSA-8874081 7.393792e-01 0.131 0 0
TRP channels R-HSA-3295583 7.393792e-01 0.131 0 0
Abacavir ADME R-HSA-2161522 7.393792e-01 0.131 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.393792e-01 0.131 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.393792e-01 0.131 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.412618e-01 0.130 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.417391e-01 0.130 0 0
HIV Life Cycle R-HSA-162587 7.428129e-01 0.129 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.470294e-01 0.127 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.470294e-01 0.127 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.495312e-01 0.125 0 0
Signaling by FGFR1 R-HSA-5654736 7.495312e-01 0.125 0 0
NRAGE signals death through JNK R-HSA-193648 7.495312e-01 0.125 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.501147e-01 0.125 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.501147e-01 0.125 0 0
Packaging Of Telomere Ends R-HSA-171306 7.501147e-01 0.125 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.501147e-01 0.125 0 0
Cristae formation R-HSA-8949613 7.501147e-01 0.125 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.501147e-01 0.125 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.501147e-01 0.125 0 0
Insulin processing R-HSA-264876 7.501147e-01 0.125 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 7.501147e-01 0.125 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.501147e-01 0.125 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.526983e-01 0.123 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.526983e-01 0.123 0 0
HIV elongation arrest and recovery R-HSA-167287 7.604087e-01 0.119 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.604087e-01 0.119 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.604087e-01 0.119 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.604087e-01 0.119 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.604087e-01 0.119 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.604087e-01 0.119 0 0
Pyroptosis R-HSA-5620971 7.604087e-01 0.119 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 7.610110e-01 0.119 0 0
Inositol phosphate metabolism R-HSA-1483249 7.637423e-01 0.117 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.691187e-01 0.114 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.702792e-01 0.113 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.702792e-01 0.113 0 0
Signaling by Erythropoietin R-HSA-9006335 7.702792e-01 0.113 0 0
DNA methylation R-HSA-5334118 7.702792e-01 0.113 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.702792e-01 0.113 0 0
Glucagon-type ligand receptors R-HSA-420092 7.702792e-01 0.113 0 0
DARPP-32 events R-HSA-180024 7.702792e-01 0.113 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.717037e-01 0.113 0 0
tRNA Aminoacylation R-HSA-379724 7.787050e-01 0.109 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.787050e-01 0.109 0 0
ER-Phagosome pathway R-HSA-1236974 7.790231e-01 0.108 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.797436e-01 0.108 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.797436e-01 0.108 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.797436e-01 0.108 0 0
Neurotransmitter clearance R-HSA-112311 7.797436e-01 0.108 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.797436e-01 0.108 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.846735e-01 0.105 0 0
Base Excision Repair R-HSA-73884 7.847736e-01 0.105 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.888187e-01 0.103 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.888187e-01 0.103 0 0
Downstream signal transduction R-HSA-186763 7.888187e-01 0.103 0 0
Mitochondrial protein import R-HSA-1268020 7.921452e-01 0.101 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.921452e-01 0.101 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.921452e-01 0.101 0 0
Heme signaling R-HSA-9707616 7.921452e-01 0.101 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.975203e-01 0.098 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.975203e-01 0.098 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.985913e-01 0.098 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.048597e-01 0.094 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.058640e-01 0.094 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.058640e-01 0.094 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.058640e-01 0.094 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.058640e-01 0.094 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.058640e-01 0.094 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.058640e-01 0.094 0 0
Cardiogenesis R-HSA-9733709 8.058640e-01 0.094 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.058640e-01 0.094 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.087312e-01 0.092 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.087312e-01 0.092 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.087312e-01 0.092 0 0
Mitochondrial protein degradation R-HSA-9837999 8.116937e-01 0.091 0 0
Collagen formation R-HSA-1474290 8.116937e-01 0.091 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.138643e-01 0.089 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.138643e-01 0.089 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.138643e-01 0.089 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.168782e-01 0.088 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.215354e-01 0.085 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.215354e-01 0.085 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.215354e-01 0.085 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.215354e-01 0.085 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.215354e-01 0.085 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.215354e-01 0.085 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.215354e-01 0.085 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.215354e-01 0.085 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.220847e-01 0.085 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.220847e-01 0.085 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.226356e-01 0.085 0 0
Kidney development R-HSA-9830369 8.226356e-01 0.085 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.255483e-01 0.083 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.264388e-01 0.083 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 8.282301e-01 0.082 0 0
Regulated Necrosis R-HSA-5218859 8.282301e-01 0.082 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.288908e-01 0.082 0 0
Regulation of Apoptosis R-HSA-169911 8.288908e-01 0.082 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.288908e-01 0.082 0 0
Gastrulation R-HSA-9758941 8.293979e-01 0.081 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.357111e-01 0.078 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.357111e-01 0.078 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.357111e-01 0.078 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.359434e-01 0.078 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.359434e-01 0.078 0 0
RNA Polymerase III Transcription R-HSA-74158 8.359434e-01 0.078 0 0
RUNX2 regulates bone development R-HSA-8941326 8.359434e-01 0.078 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.359434e-01 0.078 0 0
G1/S-Specific Transcription R-HSA-69205 8.359434e-01 0.078 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.359434e-01 0.078 0 0
Triglyceride catabolism R-HSA-163560 8.359434e-01 0.078 0 0
RET signaling R-HSA-8853659 8.359434e-01 0.078 0 0
Keratinization R-HSA-6805567 8.359762e-01 0.078 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.386832e-01 0.076 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.386832e-01 0.076 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.386832e-01 0.076 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.389446e-01 0.076 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.427058e-01 0.074 0 0
Degradation of DVL R-HSA-4641258 8.427058e-01 0.074 0 0
Cleavage of the damaged purine R-HSA-110331 8.427058e-01 0.074 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.427058e-01 0.074 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.427058e-01 0.074 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.440718e-01 0.074 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.440718e-01 0.074 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.440718e-01 0.074 0 0
Hedgehog 'on' state R-HSA-5632684 8.440718e-01 0.074 0 0
Metabolism of cofactors R-HSA-8978934 8.440718e-01 0.074 0 0
Interleukin-1 signaling R-HSA-9020702 8.488184e-01 0.071 0 0
tRNA processing in the mitochondrion R-HSA-6785470 8.491898e-01 0.071 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.491898e-01 0.071 0 0
Depurination R-HSA-73927 8.491898e-01 0.071 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.491898e-01 0.071 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.491898e-01 0.071 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.554070e-01 0.068 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.554070e-01 0.068 0 0
Stabilization of p53 R-HSA-69541 8.554070e-01 0.068 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.554070e-01 0.068 0 0
RAS processing R-HSA-9648002 8.554070e-01 0.068 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 8.585763e-01 0.066 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.613682e-01 0.065 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.613682e-01 0.065 0 0
HIV Transcription Elongation R-HSA-167169 8.613682e-01 0.065 0 0
rRNA processing in the mitochondrion R-HSA-8868766 8.613682e-01 0.065 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.613682e-01 0.065 0 0
Interleukin-2 family signaling R-HSA-451927 8.613682e-01 0.065 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.631303e-01 0.064 0 0
Interferon gamma signaling R-HSA-877300 8.642058e-01 0.063 0 0
Cardiac conduction R-HSA-5576891 8.646047e-01 0.063 0 0
RSV-host interactions R-HSA-9833110 8.648739e-01 0.063 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.670839e-01 0.062 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.670839e-01 0.062 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.670839e-01 0.062 0 0
Circadian clock R-HSA-9909396 8.680007e-01 0.061 0 0
Ion channel transport R-HSA-983712 8.686761e-01 0.061 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.725644e-01 0.059 0 0
Scavenging by Class A Receptors R-HSA-3000480 8.725644e-01 0.059 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.725644e-01 0.059 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.725644e-01 0.059 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.725644e-01 0.059 0 0
Toll-like Receptor Cascades R-HSA-168898 8.742978e-01 0.058 0 0
Interleukin-10 signaling R-HSA-6783783 8.759976e-01 0.057 0 0
Activation of GABAB receptors R-HSA-991365 8.778192e-01 0.057 0 0
GABA B receptor activation R-HSA-977444 8.778192e-01 0.057 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.778192e-01 0.057 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.794104e-01 0.056 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.828576e-01 0.054 0 0
Signaling by FGFR4 R-HSA-5654743 8.828576e-01 0.054 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.839464e-01 0.054 0 0
Proteasome assembly R-HSA-9907900 8.876886e-01 0.052 0 0
Amine ligand-binding receptors R-HSA-375280 8.876886e-01 0.052 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 8.876886e-01 0.052 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.923206e-01 0.049 0 0
Somitogenesis R-HSA-9824272 8.923206e-01 0.049 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.923206e-01 0.049 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.923206e-01 0.049 0 0
Signaling by FGFR3 R-HSA-5654741 8.923206e-01 0.049 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.949892e-01 0.048 0 0
Leishmania phagocytosis R-HSA-9664417 8.953981e-01 0.048 0 0
Parasite infection R-HSA-9664407 8.953981e-01 0.048 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.953981e-01 0.048 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.967618e-01 0.047 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.967618e-01 0.047 0 0
Diseases of DNA repair R-HSA-9675135 8.967618e-01 0.047 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.984476e-01 0.047 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.010201e-01 0.045 0 0
Late Phase of HIV Life Cycle R-HSA-162599 9.033522e-01 0.044 0 0
Metal ion SLC transporters R-HSA-425410 9.051030e-01 0.043 0 0
Ub-specific processing proteases R-HSA-5689880 9.051053e-01 0.043 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.071438e-01 0.042 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.081963e-01 0.042 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.090178e-01 0.041 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.090178e-01 0.041 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.090178e-01 0.041 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.090178e-01 0.041 0 0
G alpha (i) signalling events R-HSA-418594 9.100878e-01 0.041 1 0
Phospholipid metabolism R-HSA-1483257 9.121860e-01 0.040 0 0
PI3K Cascade R-HSA-109704 9.127712e-01 0.040 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.163701e-01 0.038 0 0
Meiotic recombination R-HSA-912446 9.163701e-01 0.038 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.163701e-01 0.038 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.163701e-01 0.038 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.198207e-01 0.036 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.198207e-01 0.036 0 0
Neurotransmitter release cycle R-HSA-112310 9.198367e-01 0.036 0 0
Downstream TCR signaling R-HSA-202424 9.198367e-01 0.036 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.198367e-01 0.036 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.222827e-01 0.035 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.231291e-01 0.035 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.263012e-01 0.033 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.276404e-01 0.033 0 0
Paracetamol ADME R-HSA-9753281 9.293425e-01 0.032 0 0
Signaling by NOTCH3 R-HSA-9012852 9.293425e-01 0.032 0 0
Peptide ligand-binding receptors R-HSA-375276 9.314186e-01 0.031 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 9.322586e-01 0.030 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.347231e-01 0.029 0 0
IRS-mediated signalling R-HSA-112399 9.350545e-01 0.029 0 0
HCMV Late Events R-HSA-9610379 9.356080e-01 0.029 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.362159e-01 0.029 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.377351e-01 0.028 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.377351e-01 0.028 0 0
Triglyceride metabolism R-HSA-8979227 9.403052e-01 0.027 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.403052e-01 0.027 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 9.411458e-01 0.026 0 0
GABA receptor activation R-HSA-977443 9.427695e-01 0.026 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.427695e-01 0.026 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.427695e-01 0.026 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.427695e-01 0.026 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.427695e-01 0.026 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.427695e-01 0.026 0 0
Signaling by FGFR R-HSA-190236 9.431500e-01 0.025 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.450891e-01 0.025 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.451321e-01 0.025 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.451321e-01 0.025 0 0
Aquaporin-mediated transport R-HSA-445717 9.451321e-01 0.025 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.451321e-01 0.025 0 0
Collagen degradation R-HSA-1442490 9.451321e-01 0.025 0 0
ABC-family proteins mediated transport R-HSA-382556 9.469653e-01 0.024 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.473973e-01 0.023 0 0
Signaling by PDGF R-HSA-186797 9.473973e-01 0.023 0 0
GPCR downstream signalling R-HSA-388396 9.476087e-01 0.023 1 0
Complex I biogenesis R-HSA-6799198 9.495692e-01 0.022 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.495692e-01 0.022 0 0
SLC transporter disorders R-HSA-5619102 9.513238e-01 0.022 0 0
Xenobiotics R-HSA-211981 9.516515e-01 0.022 0 0
IGF1R signaling cascade R-HSA-2428924 9.516515e-01 0.022 0 0
Insulin receptor signalling cascade R-HSA-74751 9.516515e-01 0.022 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.519845e-01 0.021 0 0
G alpha (q) signalling events R-HSA-416476 9.535398e-01 0.021 0 0
Cellular response to hypoxia R-HSA-1234174 9.536479e-01 0.021 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.536479e-01 0.021 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.573973e-01 0.019 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.577842e-01 0.019 0 0
Transcription of the HIV genome R-HSA-167172 9.591568e-01 0.018 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.591568e-01 0.018 0 0
Stimuli-sensing channels R-HSA-2672351 9.613105e-01 0.017 0 0
COPII-mediated vesicle transport R-HSA-204005 9.624611e-01 0.017 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.624611e-01 0.017 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.624611e-01 0.017 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.639501e-01 0.016 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.654984e-01 0.015 0 0
Purine catabolism R-HSA-74259 9.654984e-01 0.015 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.664162e-01 0.015 0 0
Aspirin ADME R-HSA-9749641 9.669238e-01 0.015 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.675877e-01 0.014 0 0
Parasitic Infection Pathways R-HSA-9824443 9.691598e-01 0.014 0 0
Leishmania infection R-HSA-9658195 9.691598e-01 0.014 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.699091e-01 0.013 0 0
Interferon alpha/beta signaling R-HSA-909733 9.718921e-01 0.012 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.720610e-01 0.012 0 0
ABC transporter disorders R-HSA-5619084 9.732156e-01 0.012 0 0
Neddylation R-HSA-8951664 9.736906e-01 0.012 0 0
Interleukin-1 family signaling R-HSA-446652 9.738181e-01 0.012 0 0
Peptide hormone metabolism R-HSA-2980736 9.738321e-01 0.012 0 0
Deubiquitination R-HSA-5688426 9.739406e-01 0.011 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.743225e-01 0.011 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.743225e-01 0.011 0 0
Protein localization R-HSA-9609507 9.746469e-01 0.011 0 0
Signaling by FGFR2 R-HSA-5654738 9.753838e-01 0.011 0 0
PPARA activates gene expression R-HSA-1989781 9.762303e-01 0.010 0 0
Amyloid fiber formation R-HSA-977225 9.764012e-01 0.010 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.764012e-01 0.010 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.773767e-01 0.010 0 0
Signaling by GPCR R-HSA-372790 9.775153e-01 0.010 1 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.777195e-01 0.010 0 0
Bacterial Infection Pathways R-HSA-9824439 9.783633e-01 0.009 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.836100e-01 0.007 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.851694e-01 0.006 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.858478e-01 0.006 0 0
Signaling by Insulin receptor R-HSA-74752 9.863710e-01 0.006 0 0
G alpha (s) signalling events R-HSA-418555 9.863710e-01 0.006 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.874139e-01 0.006 0 0
Potassium Channels R-HSA-1296071 9.889666e-01 0.005 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.889666e-01 0.005 0 0
Respiratory electron transport R-HSA-611105 9.892027e-01 0.005 0 0
Visual phototransduction R-HSA-2187338 9.924269e-01 0.003 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.932246e-01 0.003 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.935284e-01 0.003 0 0
Arachidonate metabolism R-HSA-2142753 9.937101e-01 0.003 0 0
Metabolism of nucleotides R-HSA-15869 9.943254e-01 0.002 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.945038e-01 0.002 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.949712e-01 0.002 0 0
Sphingolipid metabolism R-HSA-428157 9.950468e-01 0.002 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.953756e-01 0.002 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.956032e-01 0.002 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.968984e-01 0.001 0 0
Regulation of Complement cascade R-HSA-977606 9.971502e-01 0.001 0 0
Nucleotide catabolism R-HSA-8956319 9.976941e-01 0.001 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.988781e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.989247e-01 0.000 0 0
Complement cascade R-HSA-166658 9.989694e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.995264e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.995599e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.995948e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.996990e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.996990e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.996991e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999549e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999734e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999781e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999848e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999888e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999986e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999997e-01 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways