AMPKA1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A0MZ66	T475	Sugiyama	SHTN1 KIAA1598	tLNKSTSSRsLKsLDPENsEtELERILRRRKVtAEADsssP
A4FU28	S140	Sugiyama	CTAGE9	AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
O00418	S366	SIGNOR\|ELM\|iPTMNet\|EPSD	EEF2K	AKtILRGtEEKCGsPQVRTLsGSRPPLLRPLsENSGDENMS
O00418	S398	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	EEF2K	ENSGDENMSDVTFDsLPSsPsSATPHSQKLDHLHWPVFSDL
O00418	S78	SIGNOR\|ELM\|iPTMNet\|EPSD	EEF2K	KYysNLtKsERysssGsPANsFHFKEAWKHAIQKAKHMPDP
O00429	S637	PSP	DNM1L DLP1 DRP1	PQKGHAVNLLDVPVPVARKLsAREQRDCEVIERLIKSYFLI
O00763	S222	ELM\|EPSD\|PSP	ACACB ACC2 ACCB	EAYLTTGEAETRVPTMRPSMsGLHLVKRGREHKKLDLHRDF
O14579	S99	Sugiyama	COPE	PELQAVRMFADyLAHEsRRDsIVAELDREMsRSVDVTNTTF
O14929	S190	SIGNOR\|PSP	HAT1 KAT1	GFREYHERLQTFLMWFIETAsFIDVDDERWHYFLVFEKYNK
O14974	S445	Sugiyama	PPP1R12A MBS MYPT1	EEERKDEsPATWRLGLRKtGsyGALAEItASKEGQKEKDTA
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974	T443	Sugiyama	PPP1R12A MBS MYPT1	PKEEERKDEsPATWRLGLRKtGsyGALAEItASKEGQKEKD
O14980	S1055	Sugiyama	XPO1 CRM1	LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15067	S215	Sugiyama	PFAS KIAA0361	LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15226	T620	Sugiyama	NKRF ITBA4 NRF	KIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQIA
O15350	S426	EPSD\|PSP	TP73 P73	SYGPVLsPMNKVHGGMNKLPsVNQLVGQPPPHSSAATPNLG
O15360	S347	SIGNOR\|EPSD\|PSP	FANCA FAA FACA FANCH	ILTHSPVLKASDAVQMQREWsFARtHPLLTSLYRRLFVMLS
O15503	T222	SIGNOR\|PSP	INSIG1	WTFDRsRsGLGLGItIAFLAtLITQFLVYNGVYQYTsPDFL
O43396	S9	Sugiyama	TXNL1 TRP32 TXL TXNL	____________MVGVKPVGsDPDFQPELsGAGSRLAVVKF
O43488	S40	Sugiyama	AKR7A2 AFAR AFAR1 AKR7	SPPPEARALAMSRPPPPRVAsVLGTMEMGRRMDAPAsAAAV
O43524	S30	EPSD\|PSP	FOXO3 FKHRL1 FOXO3A	PLsPLEVELDPEFEPQSRPRsCtWPLQRPELQAsPAKPSGE
O43524	S399	SIGNOR\|EPSD\|PSP	FOXO3 FKHRL1 FOXO3A	NDGLTENLMDDLLDNITLPPsQPSPTGGLMQRSSsFPYTTK
O43524	S413	SIGNOR\|EPSD\|PSP	FOXO3 FKHRL1 FOXO3A	NITLPPsQPSPTGGLMQRSSsFPYTTKGsGLGsPtssFNst
O43524	S555	SIGNOR\|EPSD\|PSP	FOXO3 FKHRL1 FOXO3A	HHQHQTQGALGGSRALsNsVsNMGLSESSSLGSAKHQQQsP
O43524	S588	SIGNOR\|EPSD\|PSP	FOXO3 FKHRL1 FOXO3A	AKHQQQsPVSQSMQTLSDSLsGSSLYSTSANLPVMGHEKFP
O43524	S626	SIGNOR\|EPSD\|PSP	FOXO3 FKHRL1 FOXO3A	KFPSDLDLDMFNGSLECDMEsIIRSELMDADGLDFNFDsLI
O43524	T179	SIGNOR\|EPSD\|PSP	FOXO3 FKHRL1 FOXO3A	NLSYADLITRAIESSPDKRLtLSQIYEWMVRCVPYFKDKGD
O43707	T445	Sugiyama	ACTN4	HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O43707	T69	Sugiyama	ACTN4	EKQQRKTFTAWCNsHLRKAGtQIENIDEDFRDGLKLMLLLE
O43823	S323	Sugiyama	AKAP8 AKAP95	RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852	S69	Sugiyama	CALU	HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60260	S9	PSP	PRKN PARK2	____________MIVFVRFNssHGFPVEVDSDTSIFQLKEV
O60343	S588	Sugiyama	TBC1D4 AS160 KIAA0603	tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60664	T216	Sugiyama	PLIN3 M6PRBP1 TIP47	sEEWADNHLPLTDAELARIAtsLDGFDVAsVQQQRQEQSyF
O60749	S119	Sugiyama	SNX2 TRG9	AVtPVtPttLIAPRIESKsMsAPVIFDRsREEIEEEANGDI
O60825	S466	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PFKFB2	RDKPTNNFPKNQTPVRMRRNsFtPLsssNtIRRPRNYsVGs
O75385	S317	PSP	ULK1 KIAA0722	ssGSGSSSSSSSTSHLASPPsLGEMQQLQKTLAsPADTAGF
O75385	S556	PSP	ULK1 KIAA0722	PGssAPEHsPRTSGLGCRLHsAPNLSDLHVVRPKLPKPPTD
O75385	S638	EPSD\|PSP	ULK1 KIAA0722	PPILGsPtKAVPSFDFPKtPssQNLLALLARQGVVMTPPRN
O75925	S510	SIGNOR\|EPSD\|PSP	PIAS1 DDXBP1	LNNKGILsLPHQAsPVsRtPsLPAVDtsYINTsLIQDYRHP
O76003	S117	Sugiyama	GLRX3 PICOT TXNL2 HUSSY-22	IDRLDGAHAPELTKKVQRHAssGsFLPSANEHLKEDLNLRL
O95155	S105	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95210	S175	PSP	STBD1 GENX-3414	FQKGQEISAKAATCFAEKLPsSNLLKNRAKEEMsLsDLNsQ
O95239	S801	SIGNOR\|EPSD\|PSP	KIF4A KIF4	LKEKKESGENPPPKLRRRtFsLtEVRGQVsEsEDsItKQIE
O95278	S25	EPSD\|PSP	EPM2A	FGVVVPPAVAGARPELLVVGsRPELGRWEPRGAVRLRPAGT
O95863	S92	SIGNOR	SNAI1 SNAH	IAWASLRLQEsPRVAELTSLsDEDsGKGsQPPsPPsPAPsS
P00338	S105	Sugiyama	LDHA PIG19	VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00390	T507	SIGNOR\|PSP	GSR GLUR GRD1	MLQGFAVAVKMGATKADFDNtVAIHPtssEELVtLR_____
P00533	T892	EPSD\|PSP	EGFR ERBB ERBB1 HER1	EGGKVPIKWMALESILHRIytHQSDVWSYGVTVWELMTFGS
P04049	S259	SIGNOR	RAF1 RAF	tFNtssPSSEGSLSQRQRststPNVHMVsttLPVDSRMIED
P04049	S621	SIGNOR\|iPTMNet\|EPSD	RAF1 RAF	QILssIELLQHsLPKINRsAsEPsLHRAAHtEDINACtLtt
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406	S122	SIGNOR\|EPSD\|PSP	GAPDH GAPD CDABP0047 OK/SW-cl.12	FttMEKAGAHLQGGAKRVIIsAPsADAPMFVMGVNHEKYDN
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04626	T900	EPSD\|PSP	ERBB2 HER2 MLN19 NEU NGL	DGGKVPIKWMALESILRRRFtHQSDVWSYGVTVWELMTFGA
P04637	S15	SIGNOR	TP53 P53	______MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPL
P04637	S20	EPSD\|PSP	TP53 P53	_MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQAM
P04637	T18	EPSD\|PSP	TP53 P53	___MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQ
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05091	T356	SIGNOR\|PSP	ALDH2 ALDM	VERSVARAKSRVVGNPFDSKtEQGPQVDETQFKKILGYINT
P05362	S43	Sugiyama	ICAM1	GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05423	S250	Sugiyama	POLR3D BN51 BN51T	AKMKAPPKAARKTPGLPKDVsVAELLRELSLTKEEELLFLQ
P05455	S94	Sugiyama	SSB	KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P06400	S811	SIGNOR	RB1	KFPssPLRIPGGNIyIsPLKsPYKIsEGLPtPtKMtPRSRI
P06744	T109	Sugiyama	GPI	KINyTEGRAVLHVALRNRsNtPILVDGKDVMPEVNKVLDKM
P07108	S21	PSP	DBI	MsQAEFEKAAEEVRHLKTKPsDEEMLFIyGHyKQAtVGDIN
P07195	S106	Sugiyama	LDHB	VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07339	S37	Sugiyama	CTSD CPSD	PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07602	S29	Sugiyama	PSAP GLBA SAP1	SLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVKHCL
P07711	S329	Sugiyama	CTSL CTSL1	GGyVKMAKDRRNHCGIAsAAsyPtV________________
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S263	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK
P07900	S399	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07954	S75	EPSD\|PSP	FH	DtFGELKVPNDKYYGAQTVRsTMNFKIGGVTERMPtPVIKA
P08151	S102	SIGNOR	GLI1 GLI	ALsISPLSDASLDLQTVIRTsPSSLVAFINSRCTsPGGSYG
P08151	S408	SIGNOR\|EPSD\|PSP	GLI1 GLI	GPDAHVtKRHRGDGPLPRAPsISTVEPKREREGGPIREESR
P08151	T1074	SIGNOR	GLI1 GLI	DEPQGLSPPPSHDQRGSsGHtPPPsGPPNMAVGNMsVLLRS
P08238	S391	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S48	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08559	S295	SIGNOR\|PSP	PDHA1 PHE1A	SGKGPILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsKsD
P08559	S314	SIGNOR\|PSP	PDHA1 PHE1A	MsDPGVsyRtREEIQEVRsKsDPIMLLKDRMVNSNLAsVEE
P08758	T8	Sugiyama	ANXA5 ANX5 ENX2 PP4	_____________MAQVLRGtVtDFPGFDERADAEtLRKAM
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09874	S177	PSP	PARP1 ADPRT PPOL	WYHPGCFVKNREELGFRPEYsAsQLKGFsLLAtEDKEALKK
P0CG41	S140	Sugiyama	CTAGE8	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10636	S214	SIGNOR	MAPT MAPTL MTBT1 TAU	GDLHQEGPPLKGAGGKERPGsKEEVDEDRDVDESsPQDsPP
P10636	S355	SIGNOR	MAPT MAPTL MTBT1 TAU	PEARGPsLGEDTKEADLPEPsEKQPAAAPRGKPVsRVPQLK
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11532	S3624	Sugiyama	DMD	AKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEED
P11586	S318	Sugiyama	MTHFD1 MTHFC MTHFD	FKPGKWMIQYNNLNLKTPVPsDIDIsRSCKPKPIGKLAREI
P11908	S180	SIGNOR\|EPSD\|PSP	PRPS2	AEWKNCIIVSPDAGGAKRVTsIADRLNVEFALIHKERKKAN
P13569	S737	SIGNOR\|EPSD\|PSP	CFTR ABCC7	TPLQMNGIEEDSDEPLERRLsLVPDSEQGEAILPRIsVIST
P13569	S768	SIGNOR\|EPSD\|PSP	CFTR ABCC7	ILPRIsVISTGPTLQARRRQsVLNLMTHSVNQGQNIHRKTT
P13569	S813	EPSD\|PSP	CFTR ABCC7	KVsLAPQANLTELDIYsRRLsQEtGLEISEEINEEDLKECF
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13797	S540	Sugiyama	PLS3	NDDIIVNWVNRTLSEAGKSTsIQSFKDKTISSSLAVVDLID
P13798	S187	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	EKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQFV
P13798	S27	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	LsEPEEAAALyRGLSRQPALsAACLGPEVtTQyGGQyRTVH
P13798	T36	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	LyRGLSRQPALsAACLGPEVtTQyGGQyRTVHTEWtQRDLE
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14625	S109	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625	T171	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P14859	S335	EPSD\|PSP	POU2F1 OCT1 OTF1	KLYGNDFSQTTISRFEALNLsFKNMCKLKPLLEKWLNDAEN
P14859	S385	SIGNOR	POU2F1 OCT1 OTF1	PsALNsPGIEGLSRRRKKRtsIETNIRVALEKSFLENQKPT
P14866	S544	Sugiyama	HNRNPL HNRPL P/OKcl.14	LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P15056	S729	EPSD\|PSP	BRAF BRAF1 RAFB1	QILASIELLARSLPKIHRsAsEPSLNRAGFQTEDFSLYACA
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17600	S9	SIGNOR	SYN1	____________MNYLRRRLsDSNFMANLPNGYMTDLQRPQ
P18615	S135	Sugiyama	NELFE RD RDBP	sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18615	S139	Sugiyama	NELFE RD RDBP	DLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEGPGAG
P18669	S14	Sugiyama	PGAM1 PGAMA CDABP0006	_______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P19338	S328	PSP	NCL	NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19429	S150	EPSD\|PSP	TNNI3 TNNC1	QKIFDLRGKFKRPtLRRVRIsADAMMQALLGARAKEsLDLR
P19429	S23	EPSD\|PSP	TNNI3 TNNC1	DGSSDAAREPRPAPAPIRRRssNyRAYAtEPHAKKKsKIsA
P19429	S24	EPSD\|PSP	TNNI3 TNNC1	GSSDAAREPRPAPAPIRRRssNyRAYAtEPHAKKKsKIsAs
P22059	S386	Sugiyama	OSBP OSBP1	ITMPENLGHKRtGsNIsGAssDIsLDEQyKHQLEETKKEKR
P22314	S46	Sugiyama	UBA1 A1S9T UBE1	AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22460	S559	SIGNOR\|PSP	KCNA5	QGTQSQGPGLDRGVQRKVSGsRGSFCKAGGTLENADSARRG
P22460	S592	SIGNOR\|PSP	KCNA5	NADSARRGSCPLEKCNVKAKsNVDLRRSLYALCLDTSRETD
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23458	S515	EPSD\|PSP	JAK1 JAK1A JAK1B	FKNFQIEVQKGRYSLHGSDRsFPsLGDLMSHLKKQILRTDN
P23458	S518	EPSD\|PSP	JAK1 JAK1A JAK1B	FQIEVQKGRYSLHGSDRsFPsLGDLMSHLKKQILRTDNIsF
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25054	S1861	Sugiyama	APC DP2.5	DsPHHytPIEGTPYCFsRNDsLssLDFDDDDVDLSREKAEL
P25705	S198	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	GIIPRIsVREPMQTGIKAVDsLVPIGRGQRELIIGDRQTGK
P25705	T64	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	QKtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARV
P26358	S714	SIGNOR	DNMT1 AIM CXXC9 DNMT	MAMKEADDDEEVDDNIPEMPsPKKMHQGKKKKQNKNRIsWV
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T107	Sugiyama	RPL13 BBC1 OK/SW-cl.46	HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P27708	S1859	Sugiyama	CAD	RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P29401	S105	Sugiyama	TKT	VWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGsL
P29401	T442	Sugiyama	TKT	GEDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAA
P29474	S1177	SIGNOR\|EPSD\|PSP	NOS3	EDIFGLTLRTQEVTSRIRtQsFsLQERQLRGAVPWAFDPPG
P29474	S633	EPSD\|PSP	NOS3	FNsISCSDPLVssWRRKRKEssNtDSAGALGTLRFCVFGLG
P29474	T495	SIGNOR	NOS3	YQPDPWKGSAAKGTGITRKKtFKEVANAVKISASLMGTVMA
P29692	S133	Sugiyama	EEF1D EF1D	NVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPAEDDE
P29692	S162	Sugiyama	EEF1D EF1D	AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692	T147	Sugiyama	EEF1D EF1D	PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P32119	T142	Sugiyama	PRDX2 NKEFB TDPX1	EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33527	S919	Sugiyama	ABCC1 MRP MRP1	GMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQKAEA
P34897	S81	Sugiyama	SHMT2	QREKDRQCRGLELIAsENFCsRAALEALGsCLNNKYSEGYP
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35568	S794	ELM\|PSP	IRS1	tQRPGEPEEGARHQHLRLSTsSGRLLYAATADDSSSStSSD
P35613	T237	Sugiyama	BSG UNQ6505/PRO21383	LHGPPRVKAVKssEHINEGEtAMLVCKSEsVPPVTDWAWyK
P35638	S30	SIGNOR\|EPSD\|PSP	DDIT3 CHOP CHOP10 GADD153	FGTLssWELEAWYEDLQEVLssDENGGTYVSPPGNEEEESK
P35790	S279	PSP	CHKA CHK CKI	EVLRIKFTEESRIKKLHKLLsYNLPLELENLRSLLESTPSP
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646	T398	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818	S718	Sugiyama	USP8 KIAA0055 UBPY	AKPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtP
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41229	S317	Sugiyama	KDM5C DXS1272E JARID1C SMCX XE169	ELsHsPEPCtKMTMRLRRNHsNAQFIESYVCRMCSRGDEDD
P41235	S303	SIGNOR	HNF4A HNF4 NR2A1 TCF14	DNEyAyLKAIIFFDPDAKGLsDPGKIKRLRsQVQVsLEDYI
P41235	S313	ELM\|EPSD\|PSP	HNF4A HNF4 NR2A1 TCF14	IFFDPDAKGLsDPGKIKRLRsQVQVsLEDYINDRQYDSRGR
P42345	T2446	iPTMNet\|EPSD	MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1	LLNWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEP
P42677	S78	Sugiyama	RPS27 MPS1	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43405	S178	EPSD\|PSP	SYK	IATTAHEKMPWFHGKISREEsEQIVLIGSKTNGKFLIRARD
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490	S314	PSP	NAMPT PBEF PBEF1	DLRHLIVSRSTQAPLIIRPDsGNPLDTVLKVLEILGKKFPV
P43490	S472	Sugiyama	NAMPT PBEF PBEF1	EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46527	T198	SIGNOR\|EPSD\|PSP	CDKN1B KIP1 p27	sPNAGSVEQtPKKPGLRRRQt____________________
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46937	S382	Sugiyama	YAP1 YAP65	QNPVssPGMsQELRTMttNssDPFLNsGtyHsRDEstDsGL
P46937	S61	EPSD\|PSP	YAP1 YAP65	tQAAPQAPPAGHQIVHVRGDsEtDLEALFNAVMNPKtANVP
P46937	S94	EPSD\|PSP	YAP1 YAP65	NPKtANVPQtVPMRLRKLPDsFFKPPEPKsHsRQAstDAGt
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49116	S351	SIGNOR	NR2C2 TAK1 TR4	LADGIDTSGGGSIHVISRDQstPIIEVEGPLLSDTHVTFKL
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49588	S775	Sugiyama	AARS1 AARS	VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P49674	S389	EPSD\|PSP	CSNK1E	RVDRERKVSMRLHRGAPANVsssDLTGRQEVSRIPAsQtsV
P49815	S1387	PSP	TSC2 TSC4	GGRPsVDLsFQPsQPLsKssssPELQtLQDILGDPGDKADV
P50395	T394	Sugiyama	GDI2 RABGDIB	EPIEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttC
P50552	T278	EPSD\|PSP	VASP	SGGGGLMEEMNAMLARRRKAtQVGEKtPKDEsANQEEPEAR
P50990	T415	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	GVNtFKVLTRDKRLVPGGGAtEIELAKQItsyGETCPGLEQ
P52292	S105	SIGNOR\|ELM\|EPSD\|PSP	KPNA2 RCH1 SRP1	INssNVENQLQATQAARKLLsREKQPPIDNIIRAGLIPKFV
P52298	S13	Sugiyama	NCBP2 CBP20 PIG55	________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P53041	S403	Sugiyama	PPP5C PPP5	DLLWSDPQPQNGRSISKRGVsCQFGPDVTKAFLEENNLDyI
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P54646	T172	ELM	PRKAA2 AMPK AMPK2	NAKIADFGLSNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55011	S242	PSP	SLC12A2 NKCC1	PRIDHyRHtAAQLGEKLLRPsLAELHDELEKEPFEDGFANG
P55011	S77	PSP	SLC12A2 NKCC1	RDEGPAAAGDGLGRPLGPtPsQsRFQVDLVSENAGRAAAAA
P55036	S266	Sugiyama	PSMD4 MCB1	AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55060	S931	Sugiyama	CSE1L CAS XPO2	KKEHDPVGQMVNNPKIHLAQsLHKLSTACPGRVPSMVSTSL
P55212	S257	ELM	CASP6 MCH2	GKYGSSLEFTELLTLVNRKVsQRRVDFCKDPSAIGKKQVPC
P60174	T90	Sugiyama	TPI1 TPI	VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60891	S180	SIGNOR\|EPSD\|PSP	PRPS1	SEWRNCTIVSPDAGGAKRVTsIADRLNVDFALIHKERKKAN
P60900	S175	Sugiyama	PSMA6 PROS27	DPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTV
P60900	T173	Sugiyama	PSMA6 PROS27	KCDPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQ
P61081	S175	Sugiyama	UBE2M UBC12	NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62917	T146	Sugiyama	RPL8	LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P63244	T50	EPSD\|PSP	RACK1 GNB2L1 HLC7 PIG21	MILSASRDKtIIMWKLtRDEtNyGIPQRALRGHsHFVSDVV
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P83731	T83	Sugiyama	RPL24	QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
Q00587	S192	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	PHDRDRDGsFPsEPGLRRsDsLLsFRLDLDLGPSLLSELLG
Q00587	S350	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	HyPEMDARQERVEVLPQARAsWEsLDEEWRAPQAGsRtPVP
Q00613	S121	PSP	HSF1 HSTF1	HPCFLRGQEQLLENIKRKVtsVSTLKSEDIKIRQDSVTKLL
Q00613	S375	Sugiyama	HSF1 HSTF1	TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01082	T1386	Sugiyama	SPTBN1 SPTB2	ESTTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSD
Q02952	S248	Sugiyama	AKAP12 AKAP250	KESEPKQSTEKPEETLKREQsHAEIsPPAESGQAVEECKEE
Q03167	T323	Sugiyama	TGFBR3	GKESERSMTMTKSIRDDIPStQGNLVKWALDNGYSPITSYT
Q03393	T58	PSP	PTS	KLFGKCNNPNGHGHNYKVVVtVHGEIDPATGMVMNLADLKK
Q04637	S1238	Sugiyama	EIF4G1 EIF4F EIF4G EIF4GI	RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q05469	S855	SIGNOR\|ELM\|EPSD\|PSP	LIPE	SGRKSQKMSEPIAEPMRRsVsEAALAQPQGPLGTDSLKNLT
Q06210	S242	SIGNOR	GFPT1 GFAT GFPT	IPILYRTARTQIGsKFTRWGsQGERGKDKKGSCNLsRVDst
Q06210	S261	SIGNOR\|EPSD\|PSP\|Sugiyama	GFPT1 GFAT GFPT	GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06830	T143	Sugiyama	PRDX1 PAGA PAGB TDPX2	EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07866	S521	EPSD\|PSP	KLC1 KLC KNS2	VHKQRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEE
Q07955	S133	PSP	SRSF1 ASF SF2 SF2P33 SFRS1 OK/SW-cl.3	GPPSRRsENRVVVSGLPPSGsWQDLKDHMREAGDVCyADVY
Q07960	S50	Sugiyama	ARHGAP1 CDC42GAP RHOGAP1	EKNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDIARH
Q08AD1	S464	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q09028	S147	Sugiyama	RBBP4 RBAP48	VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q09472	S89	SIGNOR\|ELM\|EPSD\|PSP	EP300 P300	GMVQDAASKHKQLSELLRsGssPNLNMGVGGPGQVMAsQAQ
Q10471	S536	Sugiyama	GALNT2	NDSRQKWEQIEGNSKLRHVGsNLCLDSRTAKSGGLSVEVCG
Q12778	S22	PSP	FOXO1 FKHR FOXO1A	AEAPQVVEIDPDFEPLPRPRsCtWPLPRPEFSQSNSATSSP
Q12778	T649	EPSD\|PSP	FOXO1 FKHR FOXO1A	DFNFDNVLPNQSFPHSVKTTtHSWVSG______________
Q12888	S1317	PSP	TP53BP1	GDLGDISSFSSKAssLHRtssGtsLsAMHSSGssGKGAGPL
Q13002	S715	iPTMNet\|EPSD	GRIK2 GLUR6	KKsKISTYDKMWAFMSSRRQsVLVKSNEEGIQRVLTSDYAF
Q13085	S1201	SIGNOR\|ELM\|EPSD	ACACA ACAC ACC1 ACCA	QFMLPTSHPNRGNIPTLNRMsFssNLNHyGMtHVAsVsDVL
Q13085	S1238	EPSD	ACACA ACAC ACC1 ACCA	sDVLLDNSFTPPCQRMGGMVsFRTFEDFVRIFDEVMGCFsD
Q13085	S80	ELM\|EPSD\|PSP	ACACA ACAC ACC1 ACCA	sDLGISSLQDGLALHIRssMsGLHLVKQGRDRKKIDSQRDF
Q13131	S360	EPSD\|PSP	PRKAA1 AMPK1	DNRRIMNEAKDFyLAtsPPDsFLDDHHLTRPHPERVPFLVA
Q13131	S486	SIGNOR\|EPSD\|PSP	PRKAA1 AMPK1	DsRTYLLDFRsIDDEItEAKsGtAtPQRsGsVsNYRSCQRs
Q13131	S494	EPSD\|PSP	PRKAA1 AMPK1	FRsIDDEItEAKsGtAtPQRsGsVsNYRSCQRsDsDAEAQG
Q13131	S496	EPSD\|PSP	PRKAA1 AMPK1	sIDDEItEAKsGtAtPQRsGsVsNYRSCQRsDsDAEAQGKs
Q13131	T183	EPSD\|PSP	PRKAA1 AMPK1	NAKIADFGLsNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
Q13131	T388	EPSD\|PSP	PRKAA1 AMPK1	TRPHPERVPFLVAEtPRARHtLDELNPQKSKHQGVRKAKWH
Q13155	S51	Sugiyama	AIMP2 JTV1 PRO0992	HGRSyGPAPGAGHVQEEsNLsLQALESRQDDILKRLYELKA
Q13263	S784	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13283	S67	Sugiyama	G3BP1 G3BP	sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13309	S256	PSP	SKP2 FBXL1	NLSGCSGFSEFALQTLLSSCsRLDELNLSWCFDFTEKHVQV
Q13362	S298	EPSD\|PSP	PPP2R5C KIAA0044	DSTLTEPVVMALLKYWPKTHsPKEVMFLNELEEILDVIEPS
Q13362	S336	EPSD\|PSP	PPP2R5C KIAA0044	EPSEFVKIMEPLFRQLAKCVssPHFQVAERALYYWNNEYIM
Q13363	S158	SIGNOR\|EPSD\|PSP	CTBP1 CTBP	NLYRRAtWLHQALREGTRVQsVEQIREVASGAARIRGETLG
Q13501	S294	EPSD\|PSP	SQSTM1 ORCA OSIL	EssstEEKsssQPssCCsDPsKPGGNVEGATQsLAEQMRKI
Q13586	S257	SIGNOR\|PSP	STIM1 GOK	SKEHMKKMMKDLEGLHRAEQsLHDLQERLHKAQEEHRTVEV
Q13586	S521	PSP\|Sugiyama	STIM1 GOK	QRLTEPQHGLGsQRDLtHsDsEssLHMSDRQRVAPKPPQMS
Q13621	S130	EPSD\|PSP	SLC12A1 NKCC2	PKIEYYRNtGsIsGPKVNRPsLLEIHEQLAKNVAVTPSSAD
Q13625	S714	Sugiyama	TP53BP2 ASPP2 BBP	PRPLsPtKLLPFLSNPYRNQsDADLEALRKKLSNAPRPLKK
Q13950	S118	PSP	RUNX2 AML3 CBFA1 OSF2 PEBP2A	DNRTMVEIIADHPAELVRTDsPNFLCSVLPSHWRCNKTLPV
Q14126	S551	Sugiyama	DSG2 CDHF5	FSVIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFL
Q14152	S492	Sugiyama	EIF3A EIF3S10 KIAA0139	VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14152	T216	Sugiyama	EIF3A EIF3S10 KIAA0139	KLCDNLRMHLsQIQRHHNQstAINLNNPESQsMHLETRLVQ
Q14153	S167	Sugiyama	FAM53B KIAA0140 SMP	YsGGsVQRYSNGFSTMQRsssFSLPSRANVLssPCDQAGLH
Q14157	S859	Sugiyama	UBAP2L KIAA0144 NICE4	FPtPttPLtGRDGsLAsNPysGDLtKFGRGDASSPAPATTL
Q14204	S4162	Sugiyama	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	GRIFVFEPPPGVKANMLRTFssIPVSRICKSPNERARLYFL
Q14247	T401	EPSD\|PSP	CTTN EMS1	RQEQEEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVy
Q14432	T311	Sugiyama	PDE3A	RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14457	S90	PSP	BECN1 GT197	IETPRQDGVSRRFIPPARMMsTEsANsFTLIGEASDGGtME
Q14457	S93	PSP	BECN1 GT197	PRQDGVSRRFIPPARMMsTEsANsFTLIGEASDGGtMENLS
Q14457	S96	PSP	BECN1 GT197	DGVSRRFIPPARMMsTEsANsFTLIGEASDGGtMENLSRRL
Q14457	T388	EPSD\|PSP	BECN1 GT197	AMVAFLDCVQQFKEEVEKGEtRFCLPYRMDVEKGKIEDtGG
Q14524	T101	SIGNOR\|PSP	SCN5A	EDLDPFYSTQKTFIVLNKGKtIFRFSATNALYVLSPFHPIR
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14694	S76	SIGNOR\|EPSD\|PSP	USP10 KIAA0190	RIEFGVDEVIEPSDTLPRtPsysIsstLNPQAPEFILGCtA
Q14C86	S902	PSP\|Sugiyama	GAPVD1 GAPEX5 KIAA1521 RAP6	AEMEAFKQRHSYPERLVRsRssDIVSSVRRPMSDPSWNRRP
Q15036	S437	EPSD\|PSP	SNX17 KIAA0064	PLLEsPDAtREsMVKLSsKLsAVsLRGIGsPSTDASAsDVH
Q15172	S49	Sugiyama	PPP2R5A	VRKAQRQKRsQGssQFRsQGsQAELHPLPQLKDATSNEQQE
Q15185	S113	Sugiyama	PTGES3 P23 TEBP	RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15185	S85	Sugiyama	PTGES3 P23 TEBP	KHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVDFNN
Q15596	S269	Sugiyama	NCOA2 BHLHE75 SRC2 TIF2	LICVARRVPMKERPVLPSSEsFTTRQDLQGKITSLDTSTMR
Q15642	S296	Sugiyama	TRIP10 CIP4 STOT STP	FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15751	S1514	Sugiyama	HERC1	AESRLVHtsPNYRLIKsRsEsDLsQPEsDEEGYALsGRRNV
Q15910	T311	EPSD\|PSP	EZH2 KMT6	KYDCFLHPFHAtPNTYKRKNtETALDNKPCGPQCYQHLEGA
Q16236	S374	SIGNOR\|PSP	NFE2L2 NRF2	VAsPEHSVESSSYGDtLLGLsDSEVEELDSAPGSVKQNGPK
Q16236	S408	SIGNOR\|PSP	NFE2L2 NRF2	VKQNGPKtPVHSSGDMVQPLsPSQGQSTHVHDAQCENTPEK
Q16236	S433	SIGNOR\|PSP	NFE2L2 NRF2	QSTHVHDAQCENTPEKELPVsPGHRKtPFTKDKHSSRLEAH
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16526	S71	SIGNOR	CRY1 PHLL1	RWRFLLQCLEDLDANLRKLNsRLFVIRGQPADVFPRLFKEW
Q16576	S146	Sugiyama	RBBP7 RBAP46	VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16576	S314	SIGNOR\|PSP	RBBP7 RBAP46	DKTVALWDLRNLKLKLHTFEsHKDEIFQVHWSPHNETILAS
Q16658	S237	Sugiyama	FSCN1 FAN1 HSN SNL	RsGKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALE
Q16719	Y448	Sugiyama	KYNU	RNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsAETKN___
Q16875	S461	SIGNOR\|ELM\|EPSD\|PSP	PFKFB3	THRERSEDAKKGPNPLMRRNsVtPLAsPEPtKKPRINsFEE
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3MII6	S506	Sugiyama	TBC1D25 OATL1	DHLATASQGPGGGGRLLRQAsLDGLQQLRDNMGSRRDPLVQ
Q53ET0	S170	SIGNOR	CRTC2 TORC2	GNFPAEKGQLFRLPSALNRtssDsALHtsVMNPsPQDtYPG
Q5JSH3	S565	Sugiyama	WDR44 RPH11	DYFNNMRMKYNtEGRVsPsPsQEsLsssKsDTDtGVCsGtD
Q5SYE7	S1495	Sugiyama	NHSL1 C6orf63 KIAA1357	KNRRAQEEWAKNEGLMPRsLsFsGPRYGRSRTPPSAASSRY
Q5VWQ8	S747	Sugiyama	DAB2IP AF9Q34 AIP1 KIAA1743	ssysEANEPDLQMANGGKsLsMVDLQDARTLDGEAGsPAGP
Q6GYQ0	S860	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	DEFIAERLRSGNASTMTRRGssPGsLEIPKDLPDILNKQNQ
Q6GYQ0	S861	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	EFIAERLRSGNASTMTRRGssPGsLEIPKDLPDILNKQNQM
Q6N021	S99	SIGNOR\|PSP	TET2 KIAA1546 Nbla00191	TQESRGYSKCLQNGGIKRtVsEPsLSGLLQIKKLKQDQKAN
Q6P0Q8	S931	Sugiyama	MAST2 KIAA0807 MAST205	sEssHTESDSSPPMTVRRRCsGLLDAPRFPEGPEEASSTLR
Q6P996	S722	Sugiyama	PDXDC1 KIAA0251	PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6TCH7	T32	EPSD\|PSP	PAQR3	IELGSYQYWPVLVPRGIRLYtYEQIPGSLKDNPYITDGYRA
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71UM5	S78	Sugiyama	RPS27L	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7LBC6	S766	Sugiyama	KDM3B C5orf7 JHDM2B JMJD1B KIAA1082	tEERPtVGPGQQDNPLLKTFsNVFGRHsGGFLssPADFsQE
Q7Z3C6	S761	EPSD\|PSP	ATG9A APG9L1	sAPDEGGEGARAPQSIPRsAsYPCAAPRPGAPETTALHGGF
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z460	S545	Sugiyama	CLASP1 KIAA0622 MAST1	yHTLESSyQKALQSHLKNSDsIVsLPQsDRsssssQEsLNR
Q7Z628	S100	EPSD\|PSP	NET1 ARHGEF8	SSLDLKEPSNKRVRPLARVTsLANLIsPVRNGAVRRFGQTI
Q86TI0	S237	SIGNOR\|EPSD\|PSP	TBC1D1 KIAA1108	PHAAPTGSQEPVRRPMRKsFsQPGLRSLAFRKELQDGGLRs
Q86TI0	T596	EPSD\|PSP	TBC1D1 KIAA1108	HLPEEPAPLsPQQAFRRRANtLsHFPIECQEPPQPARGsPG
Q86UF2	S140	Sugiyama	CTAGE6 CTAGE6P	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8IX94	S140	Sugiyama	CTAGE4	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8IXJ6	T101	EPSD\|PSP	SIRT2 SIR2L SIR2L2	CLVGAGISTSAGIPDFRSPStGLyDNLEKYHLPYPEAIFEI
Q8IY63	S793	PSP	AMOTL1	QQRSRKDAGKTDsssLRPARsVPsIAAATGtHsRQtsLtSS
Q8N122	S722	EPSD\|PSP	RPTOR KIAA1303 RAPTOR	GGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSLQNL
Q8N122	S792	SIGNOR\|EPSD\|PSP	RPTOR KIAA1303 RAPTOR	PENEEHILSFETIDKMRRAssYSSLNSLIGVSFNSVYTQIW
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8ND76	S326	SIGNOR\|PSP	CCNY C10orf9 CBCP1 CFP1	SRLCEDKYKDLRRSARKRsAsADNLtLPRWsPAIIS_____
Q8NE86	S57	SIGNOR\|PSP	MCU C10orf42 CCDC109A	LGVSRHRQQQHHRTVHQRIAsWQNLGAVYCSTVVPSDDVTV
Q8TE77	S37	Sugiyama	SSH3 SSH3L	tPVGPWDQAVQRRSRLQRRQsFAVLRGAVLGLQDGGDNDDA
Q8WUF5	S102	Sugiyama	PPP1R13L IASPP NKIP1 PPP1R13BL RAI	RGsPRKAATDGADtPFGRsEsAPtLHPysPLsPKGRPssPR
Q8WUI4	S155	SIGNOR	HDAC7 HDAC7A	PPVPSLPSDPPEHFPLRKtVsEPNLKLRYKPKKSLERRKNP
Q8WUI4	S358	SIGNOR	HDAC7 HDAC7A	LMTTERLSGSGLHWPLSRtRsEPLPPSATAPPPPGPMQPRL
Q8WUI4	S405	Sugiyama	HDAC7 HDAC7A	VQVIKRSAKPSEKPRLRQIPsAEDLEtDGGGPGQVVDDGLE
Q8WVM8	S303	PSP	SCFD1 C14orf163 KIAA0917 STXBP1L2 FKSG23	DVLDFHLNRVNLEEssGVENsPAGARPKRKNKKsYDLtPVD
Q8WVM8	S316	PSP	SCFD1 C14orf163 KIAA0917 STXBP1L2 FKSG23	EssGVENsPAGARPKRKNKKsYDLtPVDKFWQKHKGSPFPE
Q8WWH5	S268	Sugiyama	TRUB1 PUS4	ECGGGFYIRSLVSDIGKELSsCANVLELTRTKQGPFTLEEH
Q92625	S663	Sugiyama	ANKS1A ANKS1 KIAA0229 ODIN	sRsEsLsNCsIGKKRLEKsPsFAsEWDEIEKIMssIGEGID
Q96BJ3	T68	Sugiyama	AIDA C1orf80	AQHNNSEFTEEQKKTIGKIAtCLELRSAALQSTQSQEEFKL
Q96HC4	S362	Sugiyama	PDLIM5 ENH L9	SLTAAAAFKPVGStGVIKsPsWQRPNQGVPstGRIsNsAtY
Q96L92	S51	Sugiyama	SNX27 KIAA0488 My014	AGNGGGGGGGPRVVRIVKsEsGYGFNVRGQVsEGGQLRSIN
Q96N67	S1432	Sugiyama	DOCK7 KIAA1771	RRSRGQLGTYTIAsPPERsPsGsAFGsQENLRWRKDMTHWR
Q96N67	S929	Sugiyama	DOCK7 KIAA1771	tsPDDEVRsIIGSKGLDRsNsWVNTGGPKAAPWGSNPsPsA
Q96PK6	S520	Sugiyama	RBM14 SIP	AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q96PU5	S795	PSP	NEDD4L KIAA0439 NEDL3	FCIDEENFGQTYQVDLKPNGsEIMVTNENKREYIDLVIQWR
Q96SI9	S6	Sugiyama	STRBP SPNR	_______________MRSIRsFANDDRHVMVKHSTIYPSPE
Q99613	S754	Sugiyama	EIF3C EIF3S8	REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK
Q99961	S64	Sugiyama	SH3GL1 CNSA1 SH3D2B	SKAVTEVLARTIEyLQPNPAsRAKLTMLNTVSKIRGQVKNP
Q99962	S64	Sugiyama	SH3GL2 CNSA2 SH3D2A	SRAVMEIMTKTIEyLQPNPAsRAKLSMINTMsKIRGQEKGP
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BRG2	S180	Sugiyama	SH2D3A NSP1 UNQ175/PRO201	EDPAGMEASTMPISALPRtssDPVLLKAPAPLGTVADsLRA
Q9BT78	S18	Sugiyama	COPS4 CSN4	___MAAAVRQDLAQLMNSsGsHKDLAGKYRQILEKAIQLSG
Q9BU19	S470	SIGNOR\|EPSD\|PSP	ZNF692 AREBP ZFP692	CEFCGKRFEKPDSVAAHRSKsHPALLLAPQESPSGPLEPCP
Q9BVJ6	S745	Sugiyama	UTP14A SDCCAG16	PGHIINPIKAEDVGYRsSsRsDLsVIQRNPKRITTRHKKQL
Q9BZL4	S452	EPSD\|PSP	PPP1R12C LENG3 MBS85	GPPERRTAEGAPGAGLQRsAsssWLEGTSTQAKELRLARIT
Q9GZT9	S136	SIGNOR\|PSP	EGLN1 C1orf12 PNAS-118 PNAS-137	PPADPAAAAsPCRAAAGGQGsAVAAEAEPGKEEPPARSSLF
Q9GZT9	S61	SIGNOR\|PSP	EGLN1 C1orf12 PNAS-118 PNAS-137	YCCKEHQRQDWKKHKLVCQGsEGALGHGVGPHQHSGPAPPA
Q9GZY8	S155	SIGNOR	MFF C2orf33 AD030 AD033 GL004	PPttPQNEEIRAVGRLKRERsMsENAVRQNGQLVRNDsLWH
Q9GZY8	S172	SIGNOR	MFF C2orf33 AD030 AD033 GL004	RERsMsENAVRQNGQLVRNDsLWHRsDsAPRNKISRFQAPI
Q9H0B6	S545	EPSD\|PSP	KLC2	DVGPTAEWNGDGsGsLRRSGsFGKLRDALRRsSEMLVKKLQ
Q9H0B6	S582	SIGNOR\|EPSD\|PSP	KLC2	KKLQGGtPQEPPNPRMKRAssLNFLNKsVEEPTQPGGTGLs
Q9H2X6	S121	SIGNOR\|PSP	HIPK2	TSVTGQVLGGPHNLMRRstVsLLDtyQKCGLKRKSEEIENT
Q9H2X6	T1114	SIGNOR\|PSP	HIPK2	AHLPTQPHLYTYTAPAALGStGtVAHLVASQGSARHTVQHT
Q9H2X6	T119	SIGNOR\|PSP	HIPK2	SSTSVTGQVLGGPHNLMRRstVsLLDtyQKCGLKRKSEEIE
Q9H3M7	S308	EPSD\|PSP	TXNIP VDUP1	VILDLPLVIGSRSGLSSRTSsMASRTSSEMSWVDLNIPDTP
Q9H3Q1	S315	Sugiyama	CDC42EP4 BORG4 CEP4	sARSMGSHTTRDSSsLssCtsGILEERsPAFRGPDRARAAV
Q9H4A3	T2245	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	TVNSQAAQAQPPAMTSSRKGtFtDDLHKLVDNWARDAMNLS
Q9H4A3	T2247	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	NSQAAQAQPPAMTSSRKGtFtDDLHKLVDNWARDAMNLSGR
Q9HAU0	S410	Sugiyama	PLEKHA5 KIAA1686 PEPP2	NRPNTGPLytEADRVIQRtNsMQQLEQWIKIQKGRGHEEET
Q9HCN8	S40	Sugiyama	SDF2L1 UNQ1941/PRO4424	ALLVPGGGAAKTGAELVTCGsVLKLLNTHHRVRLHSHDIKY
Q9HD42	S101	Sugiyama	CHMP1A CHMP1 KIAA0047 PCOLN3 PRSM1	TMKGVTKNMAQVTKALDKALsTMDLQKVSSVMDRFEQQVQN
Q9NPQ8	T441	Sugiyama	RIC8A	AARGLMAGGRPEGQysEDEDtDtDEyKEAKAsINPVTGRVE
Q9NR19	S659	SIGNOR\|EPSD\|PSP	ACSS2 ACAS2	IGPIAtPDYIQNAPGLPKTRsGKIMRRVLRKIAQNDHDLGD
Q9NRC8	T153	SIGNOR\|PSP	SIRT7 SIR2L7	RsVsAADLSEAEPTLTHMSItRLHEQKLVQHVVSQNCDGLH
Q9NY59	S209	PSP	SMPD3	SPQGGDGVARAVPGsIKRTAsVEYKGDGGRHPGDEAANGPA
Q9NYB9	S22	Sugiyama	ABI2 ARGBPIA	AELQMLLEEEIPGGRRALFDsytNLERVADyCENNyIQSAD
Q9NYV6	S635	SIGNOR\|EPSD\|PSP	RRN3 TIFIA	QNDTVIGItPSsFDtHFRsPsssVGsPPVLyMQPsPL____
Q9NZJ5	S715	PSP	EIF2AK3 PEK PERK	VKIRRMDPFATKEHIEIIAPsPQRsRSFSVGISCDQTSSSE
Q9NZJ5	S856	PSP	EIF2AK3 PEK PERK	KLTAFKPTssKSSSEATLSIsPPRPTTLSLDLTKNTTEKLQ
Q9NZM1	S727	Sugiyama	MYOF FER1L3 KIAA1207	PLTEGKANVTVLDTQIRKLRsRsLsQIHEAAVRMRSEATDV
Q9NZQ7	S195	PSP	CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1	LSGKTtTTNsKREEKLFNVtsTLRINTTTNEIFYCtFRRLD
Q9NZQ7	S283	PSP	CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1	KGRMMDVKKCGIQDtNsKKQsDtHLEEt_____________
Q9P1Y5	S431	Sugiyama	CAMSAP3 KIAA1543	FGLDSDVDVVMGDPVLLRsVssDsLGPPRPAPARTPtQPPP
Q9P2M7	S137	PSP	CGN KIAA1319	SSTSDEEPGAYWNGKLLRSHsQASLAGPGPVDPSNRSNSML
Q9UBK2	S539	SIGNOR	PPARGC1A LEM6 PGC1 PGC1A PPARGC1	DKLSYPWDGTQSYSLFNVSPsCSSFNSPCRDSVSPPKSLFS
Q9UBK2	T178	SIGNOR	PPARGC1A LEM6 PGC1 PGC1A PPARGC1	YNECSGLSTQNHANHNHRIRtNPAIVKTENSWSNKAKSICQ
Q9UGV2	S327	Sugiyama	NDRG3	KYFLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsV
Q9UGV2	S331	Sugiyama	NDRG3	QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2	T329	Sugiyama	NDRG3	FLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVts
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKV8	S387	Sugiyama	AGO2 EIF2C2	ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9UPQ0	S201	Sugiyama	LIMCH1 KIAA1102	DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ84	S746	PSP	EXO1 EXOI HEX1	HFSKKDTPLRNKVPGLYKSSsADSLSTTKIKPLGPARASGL
Q9UQK1	S293	EPSD\|PSP	PPP1R3C PPP1R5	QDCAFHQTSPKTELEsTIFGsPRLASGLFPEWQSWGRMENL
Q9UQK1	S33	EPSD\|PSP	PPP1R3C PPP1R5	RPLTSSVMPVDVAMRLCLAHsPPVKSFLGPYDEFQRRHFVN
Q9UQL6	S259	SIGNOR\|EPSD\|PSP	HDAC5 KIAA0600	KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9UQL6	S498	SIGNOR\|EPSD\|PSP	HDAC5 KIAA0600	ATSMRTVGKLPRHRPLSRtQssPLPQSPQALQQLVMQQQHQ
Q9Y297	S82	SIGNOR\|PSP	BTRC BTRCP FBW1A FBXW1A	NGEPPRKIIPEKNSLRQTYNsCARLCLNQETVCLASTAMKT
Q9Y2B0	S116	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0	T79	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	NPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGEQIDPs
Q9Y2U5	S239	Sugiyama	MAP3K2 MAPKKK2 MEKK2	SLDSPLDGESYPKSRMPRAQsyPDNHQEFSDyDNPIFEKFG
Q9Y3M2	S20	Sugiyama	CBY1 ARB1 C22orf2 CBY PGEA1 HRIHFB2025	_MPFFGNTFsPKKTPPRKsAsLsNLHsLDRSTREVELGLEY
Q9Y3M2	S22	Sugiyama	CBY1 ARB1 C22orf2 CBY PGEA1 HRIHFB2025	PFFGNTFsPKKTPPRKsAsLsNLHsLDRSTREVELGLEYGS
Q9Y3S1	T2157	Sugiyama	WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13	GPQPALHVQAQVNNSNNKKGtFtDDLHKLVDEWTSKTVGAA
Q9Y3S1	T2159	Sugiyama	WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13	QPALHVQAQVNNSNNKKGtFtDDLHKLVDEWTSKTVGAAQL
Q9Y478	S108	SIGNOR\|EPSD\|PSP	PRKAB1 AMPK	GKEVYLSGsFNNWsKLPLtRsHNNFVAILDLPEGEHQYKFF
Q9Y478	S174	EPSD\|PSP	PRKAB1 AMPK	QVKKtDFEVFDALMVDsQKCsDVsELsssPPGPyHQEPYVC
Q9Y478	S177	EPSD\|PSP	PRKAB1 AMPK	KtDFEVFDALMVDsQKCsDVsELsssPPGPyHQEPYVCKPE
Q9Y478	S24	EPSD\|PSP	PRKAB1 AMPK	TSSERAALERHGGHKTPRRDssGGTKDGDRPKILMDsPEDA
Q9Y478	T148	EPSD\|PSP	PRKAB1 AMPK	FVDGQWTHDPSEPIVTSQLGtVNNIIQVKKtDFEVFDALMV
Q9Y478	T158	EPSD\|PSP	PRKAB1 AMPK	SEPIVTSQLGtVNNIIQVKKtDFEVFDALMVDsQKCsDVsE
Q9Y478	T80	EPSD\|PSP	PRKAB1 AMPK	FLAWQHDLEVNDKAPAQARPtVFRWTGGGKEVYLSGsFNNW
Q9Y4X5	S514	Sugiyama	ARIH1 ARI MOP6 UBCH7BP HUSSY-27	NQADLENATEVLSGYLERDIsQDsLQDIKQKVQDKYRYCES
Q9Y580	S136	Sugiyama	RBM7	RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Signal Transduction	R-HSA-162582	2.079650e-09	8.682	1	0
Axon guidance	R-HSA-422475	2.176202e-08	7.662	0	0
NRAGE signals death through JNK	R-HSA-193648	2.112608e-07	6.675	0	0
Nervous system development	R-HSA-9675108	2.639333e-07	6.579	0	0
Cell Cycle	R-HSA-1640170	3.905481e-07	6.408	0	0
Mitotic Prometaphase	R-HSA-68877	5.962393e-07	6.225	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.980914e-07	6.223	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.532780e-06	5.596	0	0
G alpha (12/13) signalling events	R-HSA-416482	3.299705e-06	5.482	0	0
Cell Cycle, Mitotic	R-HSA-69278	7.071239e-06	5.151	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	7.160602e-06	5.145	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	8.947809e-06	5.048	0	0
Death Receptor Signaling	R-HSA-73887	1.659198e-05	4.780	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.906658e-05	4.720	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.235955e-05	4.651	0	0
Apoptotic execution phase	R-HSA-75153	2.863060e-05	4.543	0	0
M Phase	R-HSA-68886	3.819880e-05	4.418	0	0
Amplification of signal from the kinetochores	R-HSA-141424	4.458536e-05	4.351	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.458536e-05	4.351	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	6.843539e-05	4.165	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	8.103770e-05	4.091	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.246410e-04	3.904	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.387095e-04	3.858	0	0
Cell Cycle Checkpoints	R-HSA-69620	1.588053e-04	3.799	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.855466e-04	3.732	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.275339e-04	3.643	0	0
PI Metabolism	R-HSA-1483255	2.380436e-04	3.623	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.502584e-04	3.602	0	0
Intracellular signaling by second messengers	R-HSA-9006925	3.126450e-04	3.505	0	0
Muscle contraction	R-HSA-397014	3.236593e-04	3.490	0	0
Separation of Sister Chromatids	R-HSA-2467813	4.142897e-04	3.383	0	0
Regulation of TP53 Activity	R-HSA-5633007	8.409518e-04	3.075	1	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.735403e-04	3.012	0	0
PIP3 activates AKT signaling	R-HSA-1257604	9.678720e-04	3.014	0	0
PKMTs methylate histone lysines	R-HSA-3214841	1.021008e-03	2.991	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.079184e-03	2.967	0	0
Mitotic G2-G2/M phases	R-HSA-453274	1.093901e-03	2.961	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.291591e-03	2.889	0	0
Post NMDA receptor activation events	R-HSA-438064	1.410009e-03	2.851	1	0
RAF activation	R-HSA-5673000	1.437450e-03	2.842	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.536752e-03	2.813	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.626865e-03	2.789	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	1.688334e-03	2.773	0	0
Centrosome maturation	R-HSA-380287	1.766555e-03	2.753	0	0
Oncogenic MAPK signaling	R-HSA-6802957	1.848282e-03	2.733	0	0
Activation of RAC1	R-HSA-428540	1.992042e-03	2.701	0	0
Neurodegenerative Diseases	R-HSA-8863678	2.020803e-03	2.694	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.020803e-03	2.694	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.112994e-03	2.675	0	0
Mitotic Anaphase	R-HSA-68882	2.128588e-03	2.672	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	2.143580e-03	2.669	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.143580e-03	2.669	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.317130e-03	2.635	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.329717e-03	2.633	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.421043e-03	2.616	0	0
G2/M Transition	R-HSA-69275	2.497700e-03	2.602	0	0
Semaphorin interactions	R-HSA-373755	2.542783e-03	2.595	0	0
HDMs demethylate histones	R-HSA-3214842	2.627703e-03	2.580	0	0
Apoptosis	R-HSA-109581	3.026789e-03	2.519	0	0
Signaling by RAS mutants	R-HSA-6802949	3.387692e-03	2.470	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	3.387692e-03	2.470	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	3.387692e-03	2.470	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	3.387692e-03	2.470	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.316420e-03	2.479	0	0
TRP channels	R-HSA-3295583	3.375055e-03	2.472	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.537288e-03	2.451	0	0
Programmed Cell Death	R-HSA-5357801	3.397265e-03	2.469	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.675826e-03	2.435	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	4.031448e-03	2.395	0	0
Cellular response to heat stress	R-HSA-3371556	4.071425e-03	2.390	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.593796e-03	2.338	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	4.593796e-03	2.338	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	5.009796e-03	2.300	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	5.447254e-03	2.264	0	0
Diseases of programmed cell death	R-HSA-9645723	6.088719e-03	2.215	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	6.130442e-03	2.213	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	6.322783e-03	2.199	0	0
Signaling by RAF1 mutants	R-HSA-9656223	7.217834e-03	2.142	0	0
Sema4D in semaphorin signaling	R-HSA-400685	7.222421e-03	2.141	0	0
Striated Muscle Contraction	R-HSA-390522	7.475609e-03	2.126	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.673353e-03	2.115	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	7.965126e-03	2.099	0	0
AURKA Activation by TPX2	R-HSA-8854518	8.161821e-03	2.088	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	7.778462e-03	2.109	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	8.874396e-03	2.052	1	1
Recycling pathway of L1	R-HSA-437239	8.908123e-03	2.050	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	9.040692e-03	2.044	0	0
ALK mutants bind TKIs	R-HSA-9700645	9.438706e-03	2.025	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	9.438706e-03	2.025	0	0
Signaling by ROBO receptors	R-HSA-376176	1.002517e-02	1.999	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.043572e-02	1.981	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.070289e-02	1.970	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.070289e-02	1.970	0	0
Co-stimulation by CD28	R-HSA-389356	1.041325e-02	1.982	0	0
Rap1 signalling	R-HSA-392517	1.029258e-02	1.987	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.110231e-02	1.955	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.125808e-02	1.949	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.136638e-02	1.944	1	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.256698e-02	1.901	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.256698e-02	1.901	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.256698e-02	1.901	0	0
Netrin-1 signaling	R-HSA-373752	1.185597e-02	1.926	0	0
G2/M DNA damage checkpoint	R-HSA-69473	1.192040e-02	1.924	0	0
Signaling by WNT	R-HSA-195721	1.263027e-02	1.899	0	0
RET signaling	R-HSA-8853659	1.294420e-02	1.888	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.389921e-02	1.857	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.382929e-02	1.859	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	1.323770e-02	1.878	1	0
FLT3 Signaling	R-HSA-9607240	1.348732e-02	1.870	0	0
Kinesins	R-HSA-983189	1.403119e-02	1.853	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.459808e-02	1.836	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.575693e-02	1.803	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.579636e-02	1.801	0	0
Signaling by NTRKs	R-HSA-166520	1.592693e-02	1.798	0	0
Ion homeostasis	R-HSA-5578775	1.612224e-02	1.793	0	0
Regulation of PTEN localization	R-HSA-8948747	1.715997e-02	1.765	0	0
Resolution of D-Loop Structures	R-HSA-5693537	1.738477e-02	1.760	0	0
mRNA Splicing	R-HSA-72172	1.728061e-02	1.762	0	0
Signaling by Hippo	R-HSA-2028269	1.771393e-02	1.752	0	0
Specification of primordial germ cells	R-HSA-9827857	1.771393e-02	1.752	0	0
Chromatin modifying enzymes	R-HSA-3247509	1.844925e-02	1.734	0	0
Neurexins and neuroligins	R-HSA-6794361	1.853646e-02	1.732	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.869395e-02	1.728	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.078627e-02	1.682	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.035049e-02	1.691	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.107164e-02	1.676	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.107164e-02	1.676	0	0
Cardiac conduction	R-HSA-5576891	2.096403e-02	1.679	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.035049e-02	1.691	0	0
L1CAM interactions	R-HSA-373760	2.040434e-02	1.690	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.192625e-02	1.659	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.192625e-02	1.659	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.192625e-02	1.659	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.192625e-02	1.659	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.192625e-02	1.659	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.192625e-02	1.659	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.192625e-02	1.659	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.192625e-02	1.659	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.192625e-02	1.659	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.192625e-02	1.659	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.192625e-02	1.659	0	0
Metabolism of non-coding RNA	R-HSA-194441	2.364645e-02	1.626	0	0
snRNP Assembly	R-HSA-191859	2.364645e-02	1.626	0	0
Trafficking of AMPA receptors	R-HSA-399719	2.340336e-02	1.631	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.388331e-02	1.622	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	2.404376e-02	1.619	0	0
EPHB-mediated forward signaling	R-HSA-3928662	2.455399e-02	1.610	0	0
Type I hemidesmosome assembly	R-HSA-446107	2.458002e-02	1.609	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.458002e-02	1.609	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.458002e-02	1.609	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.507981e-02	1.601	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.507981e-02	1.601	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	2.507981e-02	1.601	0	0
Sodium/Calcium exchangers	R-HSA-425561	2.507981e-02	1.601	0	0
MAPK family signaling cascades	R-HSA-5683057	2.581484e-02	1.588	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.772260e-02	1.557	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	2.801145e-02	1.553	0	0
Regulation of TP53 Degradation	R-HSA-6804757	2.814632e-02	1.551	0	0
RAF/MAP kinase cascade	R-HSA-5673001	2.871356e-02	1.542	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.908532e-02	1.536	0	0
Signaling by VEGF	R-HSA-194138	2.947036e-02	1.531	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	3.168080e-02	1.499	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	3.277477e-02	1.484	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	3.277477e-02	1.484	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	3.277477e-02	1.484	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	3.277477e-02	1.484	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	3.277477e-02	1.484	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	3.277477e-02	1.484	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	3.012825e-02	1.521	0	0
Integrin signaling	R-HSA-354192	3.236275e-02	1.490	0	0
Regulation of necroptotic cell death	R-HSA-5675482	3.236275e-02	1.490	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.236275e-02	1.490	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.236275e-02	1.490	0	0
HSF1-dependent transactivation	R-HSA-3371571	3.153690e-02	1.501	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	3.251194e-02	1.488	0	0
Repression of WNT target genes	R-HSA-4641265	3.277477e-02	1.484	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	3.025789e-02	1.519	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	3.236275e-02	1.490	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.236275e-02	1.490	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	3.292553e-02	1.482	0	0
Neuronal System	R-HSA-112316	3.370109e-02	1.472	1	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.379604e-02	1.471	0	0
ARMS-mediated activation	R-HSA-170984	3.379604e-02	1.471	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	3.379604e-02	1.471	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	3.379604e-02	1.471	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.396196e-02	1.469	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.396196e-02	1.469	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.396196e-02	1.469	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.396196e-02	1.469	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	3.463852e-02	1.460	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.463852e-02	1.460	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.519586e-02	1.454	0	0
mRNA 3'-end processing	R-HSA-72187	3.562684e-02	1.448	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	3.607683e-02	1.443	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.765269e-02	1.424	0	0
IGF1R signaling cascade	R-HSA-2428924	4.169045e-02	1.380	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	4.040720e-02	1.394	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	3.796276e-02	1.421	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	3.850650e-02	1.414	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.185621e-02	1.378	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.185621e-02	1.378	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	4.278332e-02	1.369	0	0
Long-term potentiation	R-HSA-9620244	4.278332e-02	1.369	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.306580e-02	1.366	0	0
Autophagy	R-HSA-9612973	4.313550e-02	1.365	1	0
Interleukin-37 signaling	R-HSA-9008059	4.349280e-02	1.362	0	0
Chromatin organization	R-HSA-4839726	4.357541e-02	1.361	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.490152e-02	1.348	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.624477e-02	1.335	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	4.624477e-02	1.335	0	0
Signaling by ERBB2	R-HSA-1227986	4.821470e-02	1.317	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.907176e-02	1.309	0	0
Aggrephagy	R-HSA-9646399	4.907176e-02	1.309	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.914768e-02	1.308	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	5.635635e-02	1.249	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	5.635635e-02	1.249	0	0
Ephrin signaling	R-HSA-3928664	5.635635e-02	1.249	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	5.045458e-02	1.297	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	4.998267e-02	1.301	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	5.562594e-02	1.255	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.639193e-02	1.249	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	5.183495e-02	1.285	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.998267e-02	1.301	0	0
Polo-like kinase mediated events	R-HSA-156711	5.635635e-02	1.249	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	5.528744e-02	1.257	0	0
Selective autophagy	R-HSA-9663891	5.515412e-02	1.258	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	5.229368e-02	1.282	0	0
Signaling by ALK in cancer	R-HSA-9700206	5.229368e-02	1.282	0	0
Calmodulin induced events	R-HSA-111933	5.706560e-02	1.244	0	0
CaM pathway	R-HSA-111997	5.706560e-02	1.244	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.748780e-02	1.240	0	0
Signaling by APC mutants	R-HSA-4839744	5.794538e-02	1.237	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	5.794538e-02	1.237	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	5.794538e-02	1.237	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	5.794538e-02	1.237	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	5.812175e-02	1.236	0	0
G0 and Early G1	R-HSA-1538133	5.812175e-02	1.236	0	0
Notch-HLH transcription pathway	R-HSA-350054	5.816415e-02	1.235	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	5.816415e-02	1.235	0	0
Homology Directed Repair	R-HSA-5693538	5.843745e-02	1.233	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	5.859099e-02	1.232	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	5.859099e-02	1.232	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	5.897212e-02	1.229	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	5.988379e-02	1.223	0	0
Dopamine receptors	R-HSA-390651	5.988379e-02	1.223	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	6.186529e-02	1.209	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.186529e-02	1.209	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	6.186529e-02	1.209	0	0
Germ layer formation at gastrulation	R-HSA-9754189	6.730695e-02	1.172	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	6.773694e-02	1.169	1	1
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	6.478339e-02	1.189	0	0
Mitotic Prophase	R-HSA-68875	6.713617e-02	1.173	0	0
Meiosis	R-HSA-1500620	6.325961e-02	1.199	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	6.274353e-02	1.202	0	0
Protein-protein interactions at synapses	R-HSA-6794362	6.325961e-02	1.199	0	0
MTOR signalling	R-HSA-165159	7.043686e-02	1.152	1	0
Regulation of MECP2 expression and activity	R-HSA-9022692	6.651185e-02	1.177	0	0
The NLRP3 inflammasome	R-HSA-844456	6.730695e-02	1.172	0	0
Glycolysis	R-HSA-70171	6.793998e-02	1.168	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	7.039596e-02	1.152	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.684746e-02	1.175	0	0
ISG15 antiviral mechanism	R-HSA-1169408	7.044960e-02	1.152	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	7.060757e-02	1.151	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	7.284888e-02	1.138	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	7.284888e-02	1.138	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	7.284888e-02	1.138	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	7.293307e-02	1.137	0	0
Signaling by AMER1 mutants	R-HSA-4839748	7.293307e-02	1.137	0	0
Signaling by AXIN mutants	R-HSA-4839735	7.293307e-02	1.137	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	7.314857e-02	1.136	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	7.314857e-02	1.136	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	7.314857e-02	1.136	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	7.314857e-02	1.136	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	7.434633e-02	1.129	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	7.537958e-02	1.123	0	0
Interleukin-12 signaling	R-HSA-9020591	7.671665e-02	1.115	0	0
Potassium Channels	R-HSA-1296071	7.744531e-02	1.111	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	7.748027e-02	1.111	1	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	7.772955e-02	1.109	0	0
Prolonged ERK activation events	R-HSA-169893	7.784935e-02	1.109	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	7.784935e-02	1.109	0	0
Signaling by SCF-KIT	R-HSA-1433557	7.871517e-02	1.104	0	0
Co-inhibition by CTLA4	R-HSA-389513	7.944812e-02	1.100	0	0
Nephrin family interactions	R-HSA-373753	7.944812e-02	1.100	0	0
ESR-mediated signaling	R-HSA-8939211	7.974606e-02	1.098	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	8.566070e-02	1.067	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	8.566070e-02	1.067	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	8.566070e-02	1.067	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	8.982943e-02	1.047	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.277531e-02	1.033	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	9.113232e-02	1.040	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.857398e-02	1.053	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	8.857398e-02	1.053	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	8.857398e-02	1.053	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.550577e-02	1.068	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.550577e-02	1.068	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	9.062974e-02	1.043	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	8.566070e-02	1.067	0	0
TNF signaling	R-HSA-75893	9.582361e-02	1.019	0	0
Signaling by LTK	R-HSA-9842663	8.982943e-02	1.047	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	8.605067e-02	1.065	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	9.582361e-02	1.019	0	0
Rab regulation of trafficking	R-HSA-9007101	8.122518e-02	1.090	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	9.185123e-02	1.037	0	0
Cellular Senescence	R-HSA-2559583	9.211978e-02	1.036	0	0
NrCAM interactions	R-HSA-447038	8.566070e-02	1.067	0	0
Formation of the nephric duct	R-HSA-9830364	9.113232e-02	1.040	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	8.330132e-02	1.079	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	9.582361e-02	1.019	0	0
Signaling by Interleukins	R-HSA-449147	8.019158e-02	1.096	0	0
FOXO-mediated transcription	R-HSA-9614085	9.587660e-02	1.018	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	9.611888e-02	1.017	0	0
DAG and IP3 signaling	R-HSA-1489509	9.704777e-02	1.013	0	0
Reproduction	R-HSA-1474165	9.868817e-02	1.006	0	0
Macroautophagy	R-HSA-1632852	9.873542e-02	1.006	1	1
Heme signaling	R-HSA-9707616	9.893431e-02	1.005	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	9.893431e-02	1.005	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.002683e-01	0.999	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.002683e-01	0.999	0	0
Downstream signal transduction	R-HSA-186763	1.002683e-01	0.999	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.029055e-01	0.988	0	0
Lipophagy	R-HSA-9613354	1.029055e-01	0.988	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.029055e-01	0.988	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.029055e-01	0.988	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	1.040999e-01	0.983	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	1.040999e-01	0.983	0	0
Estrogen-dependent gene expression	R-HSA-9018519	1.045386e-01	0.981	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.054099e-01	0.977	0	0
Membrane Trafficking	R-HSA-199991	1.066125e-01	0.972	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	1.071043e-01	0.970	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.085627e-01	0.964	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	1.091577e-01	0.962	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.091577e-01	0.962	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.367024e-01	0.864	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.367024e-01	0.864	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.367024e-01	0.864	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.367024e-01	0.864	0	0
Regulation of TP53 Expression	R-HSA-6804754	1.179378e-01	0.928	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	1.179378e-01	0.928	0	0
Potassium transport channels	R-HSA-1296067	1.179378e-01	0.928	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	2.547241e-01	0.594	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.547241e-01	0.594	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.547241e-01	0.594	0	0
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.547241e-01	0.594	0	0
TICAM1 deficiency - HSE	R-HSA-5602566	2.547241e-01	0.594	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.547241e-01	0.594	0	0
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.547241e-01	0.594	0	0
TWIK-related spinal cord K+ channel (TRESK)	R-HSA-1299344	2.547241e-01	0.594	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.547241e-01	0.594	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.547241e-01	0.594	0	0
Defective Mismatch Repair Associated With MSH3	R-HSA-5632927	2.547241e-01	0.594	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.547241e-01	0.594	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.547241e-01	0.594	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	1.680281e-01	0.775	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	1.680281e-01	0.775	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	1.152917e-01	0.938	0	0
TRAIL signaling	R-HSA-75158	1.152917e-01	0.938	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	1.152917e-01	0.938	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.481541e-01	0.829	0	0
CREB phosphorylation	R-HSA-199920	1.481541e-01	0.829	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	1.481541e-01	0.829	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.209110e-01	0.656	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.209110e-01	0.656	0	0
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.566168e-01	0.448	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.566168e-01	0.448	0	0
Mitochondrial transcription initiation	R-HSA-163282	3.566168e-01	0.448	0	0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.566168e-01	0.448	0	0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.566168e-01	0.448	0	0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.566168e-01	0.448	0	0
Defective APRT disrupts adenine salvage	R-HSA-9734195	3.566168e-01	0.448	0	0
TRAF3 deficiency - HSE	R-HSA-5602571	3.566168e-01	0.448	0	0
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	3.566168e-01	0.448	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.566168e-01	0.448	0	0
Intestinal infectious diseases	R-HSA-8942233	3.566168e-01	0.448	0	0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.566168e-01	0.448	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	3.566168e-01	0.448	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	3.566168e-01	0.448	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.566168e-01	0.448	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	3.566168e-01	0.448	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	3.566168e-01	0.448	0	0
XAV939 stabilizes AXIN	R-HSA-5545619	3.566168e-01	0.448	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	1.270893e-01	0.896	0	0
PI3K/AKT activation	R-HSA-198203	1.270893e-01	0.896	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.270893e-01	0.896	0	0
Folding of actin by CCT/TriC	R-HSA-390450	1.270893e-01	0.896	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.835984e-01	0.736	0	0
SOS-mediated signalling	R-HSA-112412	1.835984e-01	0.736	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	1.835984e-01	0.736	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.835984e-01	0.736	0	0
IRS activation	R-HSA-74713	2.748879e-01	0.561	0	0
G2 Phase	R-HSA-68911	2.748879e-01	0.561	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	2.748879e-01	0.561	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.748879e-01	0.561	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	2.209850e-01	0.656	0	0
Regulation by c-FLIP	R-HSA-3371378	2.209850e-01	0.656	0	0
Dimerization of procaspase-8	R-HSA-69416	2.209850e-01	0.656	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	2.209850e-01	0.656	0	0
FGFR1b ligand binding and activation	R-HSA-190370	2.209850e-01	0.656	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.209850e-01	0.656	0	0
DCC mediated attractive signaling	R-HSA-418885	1.510989e-01	0.821	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.510989e-01	0.821	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.112109e-01	0.675	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.112109e-01	0.675	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	2.112109e-01	0.675	0	0
CASP8 activity is inhibited	R-HSA-5218900	2.597077e-01	0.586	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.286720e-01	0.483	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	3.286720e-01	0.483	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.286720e-01	0.483	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	3.286720e-01	0.483	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.286720e-01	0.483	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	3.286720e-01	0.483	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	3.286720e-01	0.483	0	0
Signaling by MAPK mutants	R-HSA-9652817	3.286720e-01	0.483	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.445841e-01	0.352	0	0
Essential pentosuria	R-HSA-5662853	4.445841e-01	0.352	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.445841e-01	0.352	0	0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	4.445841e-01	0.352	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.445841e-01	0.352	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	4.445841e-01	0.352	0	0
Signaling by RAS GAP mutants	R-HSA-9753510	4.445841e-01	0.352	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.180351e-01	0.928	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	1.994266e-01	0.700	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	1.329109e-01	0.876	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.421217e-01	0.616	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.573776e-01	0.803	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	1.261638e-01	0.899	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	2.992097e-01	0.524	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	2.992097e-01	0.524	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	2.992097e-01	0.524	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	1.486920e-01	0.828	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.486920e-01	0.828	0	0
Voltage gated Potassium channels	R-HSA-1296072	1.195606e-01	0.922	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.253393e-01	0.647	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.253393e-01	0.647	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.403267e-01	0.853	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.403267e-01	0.853	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.653353e-01	0.782	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	1.653353e-01	0.782	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.653353e-01	0.782	0	0
cGMP effects	R-HSA-418457	2.739627e-01	0.562	0	0
STAT5 Activation	R-HSA-9645135	3.813076e-01	0.419	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.521744e-01	0.598	0	0
FGFR2 alternative splicing	R-HSA-6803529	2.330893e-01	0.632	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.389918e-01	0.470	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.389918e-01	0.470	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	3.389918e-01	0.470	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	3.389918e-01	0.470	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	2.161621e-01	0.665	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.161621e-01	0.665	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.161621e-01	0.665	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.010007e-01	0.697	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	3.064414e-01	0.514	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	3.064414e-01	0.514	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	3.064414e-01	0.514	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	3.064414e-01	0.514	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	2.797455e-01	0.553	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	2.570543e-01	0.590	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	1.347377e-01	0.871	0	0
HIV elongation arrest and recovery	R-HSA-167287	2.373257e-01	0.625	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	2.373257e-01	0.625	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	1.794575e-01	0.746	0	0
Late endosomal microautophagy	R-HSA-9615710	2.591255e-01	0.586	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.591255e-01	0.586	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	3.078681e-01	0.512	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	3.392807e-01	0.469	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	3.392807e-01	0.469	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.392807e-01	0.469	0	0
Phosphorylation of the APC/C	R-HSA-176412	3.392807e-01	0.469	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	3.392807e-01	0.469	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	3.786170e-01	0.422	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	3.786170e-01	0.422	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.786170e-01	0.422	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	4.321038e-01	0.364	0	0
Netrin mediated repulsion signals	R-HSA-418886	4.321038e-01	0.364	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	4.321038e-01	0.364	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.321038e-01	0.364	0	0
Disinhibition of SNARE formation	R-HSA-114516	4.321038e-01	0.364	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	5.205283e-01	0.284	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	5.205283e-01	0.284	0	0
Axonal growth stimulation	R-HSA-209563	5.205283e-01	0.284	0	0
Defective GCLC causes HAGGSD	R-HSA-5578999	5.205283e-01	0.284	0	0
MET activates PTPN11	R-HSA-8865999	5.205283e-01	0.284	0	0
Invadopodia formation	R-HSA-8941237	5.205283e-01	0.284	0	0
Defective CYP1B1 causes Glaucoma	R-HSA-5579000	5.205283e-01	0.284	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	1.689208e-01	0.772	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.933784e-01	0.714	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.401749e-01	0.619	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	2.595244e-01	0.586	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.814674e-01	0.551	1	1
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.363623e-01	0.473	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.363623e-01	0.473	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	3.363623e-01	0.473	0	0
HIV Transcription Elongation	R-HSA-167169	2.588655e-01	0.587	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.588655e-01	0.587	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.588655e-01	0.587	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	2.800985e-01	0.553	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	2.800985e-01	0.553	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.722232e-01	0.429	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.722232e-01	0.429	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.722232e-01	0.429	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.575094e-01	0.589	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.691515e-01	0.772	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	4.177110e-01	0.379	0	0
Polymerase switching	R-HSA-69091	4.177110e-01	0.379	0	0
Leading Strand Synthesis	R-HSA-69109	4.177110e-01	0.379	0	0
G1/S-Specific Transcription	R-HSA-69205	3.010839e-01	0.521	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	3.650556e-01	0.438	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	3.650556e-01	0.438	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.761340e-01	0.754	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.007147e-01	0.697	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.871812e-01	0.728	0	0
Signaling by FGFR2	R-HSA-5654738	2.301951e-01	0.638	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.578369e-01	0.446	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	4.050335e-01	0.393	0	0
RSK activation	R-HSA-444257	4.805798e-01	0.318	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	4.805798e-01	0.318	0	0
Meiotic synapsis	R-HSA-1221632	2.898106e-01	0.538	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	3.507912e-01	0.455	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	2.232155e-01	0.651	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	3.937849e-01	0.405	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	3.937849e-01	0.405	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	2.292664e-01	0.640	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	3.836357e-01	0.416	0	0
Telomere Extension By Telomerase	R-HSA-171319	3.836357e-01	0.416	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.559597e-01	0.341	0	0
Formation of axial mesoderm	R-HSA-9796292	4.559597e-01	0.341	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.403991e-01	0.619	0	0
Interleukin receptor SHC signaling	R-HSA-912526	4.223981e-01	0.374	0	0
Signaling by Erythropoietin	R-HSA-9006335	4.094384e-01	0.388	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	4.094384e-01	0.388	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	3.876483e-01	0.412	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	3.069203e-01	0.513	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	3.464044e-01	0.460	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.096030e-01	0.509	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	3.987182e-01	0.399	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	4.095793e-01	0.388	0	0
DAP12 signaling	R-HSA-2424491	4.351366e-01	0.361	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.507555e-01	0.346	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	4.507555e-01	0.346	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	4.507555e-01	0.346	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	4.694365e-01	0.328	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.694365e-01	0.328	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	4.694365e-01	0.328	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	4.931068e-01	0.307	0	0
Retrograde neurotrophin signalling	R-HSA-177504	4.931068e-01	0.307	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	4.931068e-01	0.307	0	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	5.264206e-01	0.279	0	0
Interleukin-21 signaling	R-HSA-9020958	5.264206e-01	0.279	0	0
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	5.264206e-01	0.279	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	4.081650e-01	0.389	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.192686e-01	0.378	0	0
PRC2 methylates histones and DNA	R-HSA-212300	4.451221e-01	0.352	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	3.778961e-01	0.423	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.690529e-01	0.433	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.690529e-01	0.433	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	4.787301e-01	0.320	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	4.787301e-01	0.320	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	4.036246e-01	0.394	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	5.006805e-01	0.300	0	0
Transcription of the HIV genome	R-HSA-167172	4.412260e-01	0.355	0	0
Spry regulation of FGF signaling	R-HSA-1295596	5.289481e-01	0.277	0	0
Erythropoietin activates RAS	R-HSA-9027284	5.289481e-01	0.277	0	0
Processive synthesis on the lagging strand	R-HSA-69183	5.289481e-01	0.277	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.289481e-01	0.277	0	0
SHC1 events in EGFR signaling	R-HSA-180336	5.289481e-01	0.277	0	0
Defective pyroptosis	R-HSA-9710421	4.749719e-01	0.323	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	5.062083e-01	0.296	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	5.062083e-01	0.296	0	0
Regulation of RAS by GAPs	R-HSA-5658442	4.805278e-01	0.318	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	5.310945e-01	0.275	0	0
Lagging Strand Synthesis	R-HSA-69186	5.310945e-01	0.275	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.310945e-01	0.275	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	4.936041e-01	0.307	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.330900e-01	0.273	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	5.330900e-01	0.273	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	5.330900e-01	0.273	0	0
Viral mRNA Translation	R-HSA-192823	5.089719e-01	0.293	0	0
Attenuation phase	R-HSA-3371568	5.367818e-01	0.270	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.592886e-01	0.252	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.592886e-01	0.252	0	0
Formation of the Early Elongation Complex	R-HSA-113418	5.592886e-01	0.252	0	0
Signaling by NOTCH2	R-HSA-1980145	5.587993e-01	0.253	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.587993e-01	0.253	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	4.269767e-01	0.370	0	0
EGFR downregulation	R-HSA-182971	4.606290e-01	0.337	0	0
Signaling by FGFR3	R-HSA-5654741	2.575094e-01	0.589	0	0
Eukaryotic Translation Initiation	R-HSA-72613	2.824690e-01	0.549	0	0
Signaling by FGFR4	R-HSA-5654743	2.229251e-01	0.652	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	2.208017e-01	0.656	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.570696e-01	0.804	0	0
Cap-dependent Translation Initiation	R-HSA-72737	2.824690e-01	0.549	0	0
Signaling by FGFR	R-HSA-190236	4.362319e-01	0.360	0	0
Specification of the neural plate border	R-HSA-9834899	1.459343e-01	0.836	0	0
HATs acetylate histones	R-HSA-3214847	4.508612e-01	0.346	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	5.106316e-01	0.292	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	1.653353e-01	0.782	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	1.270893e-01	0.896	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.396211e-01	0.855	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	1.456711e-01	0.837	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.559597e-01	0.341	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	3.937849e-01	0.405	0	0
Epigenetic regulation of gene expression	R-HSA-212165	3.238304e-01	0.490	0	0
Hedgehog 'off' state	R-HSA-5610787	4.654687e-01	0.332	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	1.270893e-01	0.896	0	0
Signaling by EGFR	R-HSA-177929	2.378777e-01	0.624	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	3.363869e-01	0.473	0	0
Circadian clock	R-HSA-9909396	5.077644e-01	0.294	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.486648e-01	0.828	0	0
DNA Double Strand Break Response	R-HSA-5693606	1.472239e-01	0.832	0	0
Signaling by FGFR1	R-HSA-5654736	3.431245e-01	0.465	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	2.520504e-01	0.599	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	2.520504e-01	0.599	0	0
Chaperonin-mediated protein folding	R-HSA-390466	3.414128e-01	0.467	0	0
Extension of Telomeres	R-HSA-180786	3.979628e-01	0.400	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	1.835984e-01	0.736	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.635385e-01	0.786	0	0
IRS-mediated signalling	R-HSA-112399	1.677753e-01	0.775	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	5.442095e-01	0.264	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	1.698804e-01	0.770	0	0
Insulin receptor signalling cascade	R-HSA-74751	1.812104e-01	0.742	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	3.536333e-01	0.451	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	2.520504e-01	0.599	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.112109e-01	0.675	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.964600e-01	0.402	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	5.362362e-01	0.271	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.722232e-01	0.429	0	0
TCR signaling	R-HSA-202403	5.253969e-01	0.280	0	0
Signal attenuation	R-HSA-74749	2.992097e-01	0.524	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	2.739627e-01	0.562	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	1.552634e-01	0.809	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	3.937849e-01	0.405	0	0
Myogenesis	R-HSA-525793	5.062083e-01	0.296	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	5.310945e-01	0.275	0	0
Frs2-mediated activation	R-HSA-170968	2.421217e-01	0.616	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.232155e-01	0.651	0	0
MHC class II antigen presentation	R-HSA-2132295	2.894372e-01	0.538	0	0
p75NTR signals via NF-kB	R-HSA-193639	5.289481e-01	0.277	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	1.815328e-01	0.741	0	0
Regulation of the apoptosome activity	R-HSA-9627069	2.992097e-01	0.524	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	2.992097e-01	0.524	0	0
MAP2K and MAPK activation	R-HSA-5674135	1.131927e-01	0.946	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.521744e-01	0.598	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.521744e-01	0.598	0	0
PI3K Cascade	R-HSA-109704	1.531367e-01	0.815	0	0
DARPP-32 events	R-HSA-180024	4.094384e-01	0.388	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.580706e-01	0.446	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.189951e-01	0.924	0	0
Triglyceride catabolism	R-HSA-163560	3.010839e-01	0.521	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.323639e-01	0.634	0	0
Protein folding	R-HSA-391251	4.312017e-01	0.365	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.722232e-01	0.429	0	0
RMTs methylate histone arginines	R-HSA-3214858	4.964301e-01	0.304	0	0
Signalling to ERKs	R-HSA-187687	1.709395e-01	0.767	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	3.578369e-01	0.446	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.180351e-01	0.928	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	4.094384e-01	0.388	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.209110e-01	0.656	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.835984e-01	0.736	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	1.835984e-01	0.736	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.421217e-01	0.616	0	0
Formation of apoptosome	R-HSA-111458	2.992097e-01	0.524	0	0
Meiotic recombination	R-HSA-912446	1.660362e-01	0.780	0	0
Peptide chain elongation	R-HSA-156902	1.910783e-01	0.719	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	4.805798e-01	0.318	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	2.631242e-01	0.580	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	3.937849e-01	0.405	0	0
Processing of SMDT1	R-HSA-8949664	4.559597e-01	0.341	0	0
CRMPs in Sema3A signaling	R-HSA-399956	4.931068e-01	0.307	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	5.264206e-01	0.279	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.061616e-01	0.686	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.595244e-01	0.586	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.797455e-01	0.553	0	0
Eukaryotic Translation Elongation	R-HSA-156842	1.236887e-01	0.908	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	5.349799e-01	0.272	0	0
Interleukin-9 signaling	R-HSA-8985947	4.805798e-01	0.318	0	0
Signaling by Hedgehog	R-HSA-5358351	4.268360e-01	0.370	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.533047e-01	0.344	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.957258e-01	0.708	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.076061e-01	0.683	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.076061e-01	0.683	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.076061e-01	0.683	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.076061e-01	0.683	0	0
Bicarbonate transporters	R-HSA-425381	1.533925e-01	0.814	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	2.748879e-01	0.561	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	2.748879e-01	0.561	0	0
Adrenoceptors	R-HSA-390696	2.209850e-01	0.656	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	2.112109e-01	0.675	0	0
Signaling by WNT in cancer	R-HSA-4791275	1.128035e-01	0.948	0	0
Platelet calcium homeostasis	R-HSA-418360	1.486920e-01	0.828	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.813076e-01	0.419	0	0
Apoptotic factor-mediated response	R-HSA-111471	2.521744e-01	0.598	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	2.521744e-01	0.598	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	3.392807e-01	0.469	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.177110e-01	0.379	0	0
Regulation of IFNG signaling	R-HSA-877312	4.177110e-01	0.379	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	4.559597e-01	0.341	0	0
WNT mediated activation of DVL	R-HSA-201688	5.264206e-01	0.279	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	5.264206e-01	0.279	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	5.289481e-01	0.277	0	0
Cellular response to starvation	R-HSA-9711097	5.163329e-01	0.287	0	0
Opioid Signalling	R-HSA-111885	4.267003e-01	0.370	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.510427e-01	0.821	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.709395e-01	0.767	0	0
Activation of BH3-only proteins	R-HSA-114452	1.653353e-01	0.782	0	0
G-protein mediated events	R-HSA-112040	3.137199e-01	0.503	0	0
Hedgehog 'on' state	R-HSA-5632684	4.936041e-01	0.307	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.816394e-01	0.550	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.582000e-01	0.801	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	5.106316e-01	0.292	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.957258e-01	0.708	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	5.375281e-01	0.270	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	5.375281e-01	0.270	0	0
Signaling by NOTCH1	R-HSA-1980143	1.206559e-01	0.918	0	0
Regulated Necrosis	R-HSA-5218859	1.582000e-01	0.801	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	2.209850e-01	0.656	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	2.992097e-01	0.524	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	4.177110e-01	0.379	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	4.469318e-01	0.350	0	0
S Phase	R-HSA-69242	3.248197e-01	0.488	0	0
G2/M Checkpoints	R-HSA-69481	1.543257e-01	0.812	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	2.098726e-01	0.678	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	3.887765e-01	0.410	0	0
Gene expression (Transcription)	R-HSA-74160	2.449807e-01	0.611	1	0
RNA Polymerase II Transcription	R-HSA-73857	2.635983e-01	0.579	1	0
Signaling by Insulin receptor	R-HSA-74752	5.339635e-01	0.272	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	3.676845e-01	0.435	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.152917e-01	0.938	0	0
Calcineurin activates NFAT	R-HSA-2025928	2.597077e-01	0.586	0	0
Transcription from mitochondrial promoters	R-HSA-75944	4.445841e-01	0.352	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.739627e-01	0.562	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.199045e-01	0.658	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.078681e-01	0.512	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	3.786170e-01	0.422	0	0
Ca2+ activated K+ channels	R-HSA-1296052	4.321038e-01	0.364	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.205283e-01	0.284	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.593871e-01	0.798	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.722232e-01	0.429	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	4.050335e-01	0.393	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.805798e-01	0.318	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	4.805798e-01	0.318	0	0
TGFBR3 PTM regulation	R-HSA-9839383	4.805798e-01	0.318	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	4.805798e-01	0.318	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	4.559597e-01	0.341	0	0
FGFR1c ligand binding and activation	R-HSA-190373	4.559597e-01	0.341	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.311663e-01	0.480	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	4.375001e-01	0.359	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.787301e-01	0.320	0	0
Activation of ATR in response to replication stress	R-HSA-176187	5.106316e-01	0.292	0	0
Triglyceride metabolism	R-HSA-8979227	5.231919e-01	0.281	0	0
Interleukin-2 family signaling	R-HSA-451927	1.600549e-01	0.796	0	0
Generic Transcription Pathway	R-HSA-212436	3.046386e-01	0.516	1	0
PLC beta mediated events	R-HSA-112043	2.217394e-01	0.654	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	2.570543e-01	0.590	0	0
Signaling by FGFR in disease	R-HSA-1226099	2.323639e-01	0.634	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	2.804963e-01	0.552	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	3.722232e-01	0.429	0	0
Interleukin-2 signaling	R-HSA-9020558	3.389918e-01	0.470	0	0
Ca2+ pathway	R-HSA-4086398	4.132914e-01	0.384	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	2.816394e-01	0.550	0	0
Regulation of KIT signaling	R-HSA-1433559	4.931068e-01	0.307	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	5.330900e-01	0.273	0	0
Formation of definitive endoderm	R-HSA-9823730	3.078681e-01	0.512	0	0
Host Interactions of HIV factors	R-HSA-162909	2.311366e-01	0.636	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.930093e-01	0.533	0	0
FasL/ CD95L signaling	R-HSA-75157	1.680281e-01	0.775	0	0
Nef and signal transduction	R-HSA-164944	1.481541e-01	0.829	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	1.746204e-01	0.758	0	0
Formation of intermediate mesoderm	R-HSA-9761174	2.992097e-01	0.524	0	0
Leukotriene receptors	R-HSA-391906	3.813076e-01	0.419	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	3.064414e-01	0.514	0	0
G-protein beta:gamma signalling	R-HSA-397795	2.199045e-01	0.658	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.321038e-01	0.364	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.321569e-01	0.479	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	4.931068e-01	0.307	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	5.264206e-01	0.279	0	0
Eukaryotic Translation Termination	R-HSA-72764	3.924123e-01	0.406	0	0
Nuclear RNA decay	R-HSA-9930044	5.106316e-01	0.292	0	0
Transmission across Chemical Synapses	R-HSA-112315	3.238304e-01	0.490	1	0
Transcriptional regulation by RUNX3	R-HSA-8878159	5.211061e-01	0.283	0	0
NGF-stimulated transcription	R-HSA-9031628	2.074163e-01	0.683	0	0
Ca-dependent events	R-HSA-111996	1.248408e-01	0.904	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.076061e-01	0.683	0	0
PTEN Regulation	R-HSA-6807070	2.865556e-01	0.543	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.787301e-01	0.320	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	4.198152e-01	0.377	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	3.427887e-01	0.465	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	4.667727e-01	0.331	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	4.667727e-01	0.331	0	0
HIV Infection	R-HSA-162906	1.503220e-01	0.823	0	0
HIV Life Cycle	R-HSA-162587	1.276342e-01	0.894	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.815328e-01	0.741	0	0
Ovarian tumor domain proteases	R-HSA-5689896	3.224060e-01	0.492	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.507912e-01	0.455	0	0
Deubiquitination	R-HSA-5688426	2.540551e-01	0.595	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.289481e-01	0.277	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.289481e-01	0.277	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.628729e-01	0.440	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.427887e-01	0.465	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	3.141966e-01	0.503	0	0
Protein methylation	R-HSA-8876725	3.064414e-01	0.514	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	2.695129e-01	0.569	0	0
mRNA Editing	R-HSA-75072	5.264206e-01	0.279	0	0
Cellular responses to stress	R-HSA-2262752	2.826034e-01	0.549	0	0
Developmental Biology	R-HSA-1266738	4.663332e-01	0.331	0	0
Metabolism of RNA	R-HSA-8953854	3.301650e-01	0.481	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.994266e-01	0.700	0	0
Cellular responses to stimuli	R-HSA-8953897	2.333687e-01	0.632	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	5.340051e-01	0.272	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.937849e-01	0.405	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	4.192686e-01	0.378	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.722337e-01	0.565	0	0
Signaling by ERBB4	R-HSA-1236394	3.238449e-01	0.490	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	4.852377e-01	0.314	0	0
Signaling by PTK6	R-HSA-8848021	3.536333e-01	0.451	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	3.536333e-01	0.451	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	2.547241e-01	0.594	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	2.209110e-01	0.656	0	0
Tandem pore domain potassium channels	R-HSA-1296346	1.270893e-01	0.896	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	1.835984e-01	0.736	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	2.748879e-01	0.561	0	0
Co-stimulation by ICOS	R-HSA-9927354	2.209850e-01	0.656	0	0
Cell-extracellular matrix interactions	R-HSA-446353	1.510989e-01	0.821	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.597077e-01	0.586	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	4.445841e-01	0.352	0	0
C6 deamination of adenosine	R-HSA-75102	4.445841e-01	0.352	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	4.445841e-01	0.352	0	0
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.445841e-01	0.352	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.421217e-01	0.616	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	2.992097e-01	0.524	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.253393e-01	0.647	0	0
Signaling by PDGFR in disease	R-HSA-9671555	2.098726e-01	0.678	0	0
Metalloprotease DUBs	R-HSA-5689901	1.957258e-01	0.708	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.521744e-01	0.598	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	2.330893e-01	0.632	0	0
mTORC1-mediated signalling	R-HSA-166208	2.330893e-01	0.632	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	3.389918e-01	0.470	0	0
Smooth Muscle Contraction	R-HSA-445355	1.213858e-01	0.916	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.043462e-01	0.690	0	0
Negative regulation of MET activity	R-HSA-6807004	3.078681e-01	0.512	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	5.205283e-01	0.284	0	0
Amine ligand-binding receptors	R-HSA-375280	2.399904e-01	0.620	0	0
VLDLR internalisation and degradation	R-HSA-8866427	4.177110e-01	0.379	0	0
FLT3 signaling in disease	R-HSA-9682385	3.010839e-01	0.521	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	4.805798e-01	0.318	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.805798e-01	0.318	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	4.805798e-01	0.318	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	4.559597e-01	0.341	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	2.634994e-01	0.579	0	0
Budding and maturation of HIV virion	R-HSA-162588	4.606290e-01	0.337	0	0
Cilium Assembly	R-HSA-5617833	3.634188e-01	0.440	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.715059e-01	0.327	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.349799e-01	0.272	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.010007e-01	0.697	0	0
GPVI-mediated activation cascade	R-HSA-114604	3.010839e-01	0.521	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.781931e-01	0.422	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.024592e-01	0.519	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	4.931068e-01	0.307	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	4.095793e-01	0.388	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.813967e-01	0.741	0	0
Signaling by NOTCH3	R-HSA-9012852	4.469318e-01	0.350	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.685133e-01	0.773	0	0
Cell-Cell communication	R-HSA-1500931	4.844606e-01	0.315	0	0
Interleukin-6 signaling	R-HSA-1059683	4.559597e-01	0.341	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	3.096030e-01	0.509	0	0
Signaling by MET	R-HSA-6806834	5.300402e-01	0.276	0	0
PECAM1 interactions	R-HSA-210990	3.389918e-01	0.470	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	3.064414e-01	0.514	0	0
TBC/RABGAPs	R-HSA-8854214	2.229251e-01	0.652	0	0
Selenocysteine synthesis	R-HSA-2408557	3.842426e-01	0.415	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.412260e-01	0.355	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	2.936615e-01	0.532	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.507912e-01	0.455	0	0
Phospholipid metabolism	R-HSA-1483257	1.777170e-01	0.750	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	4.936041e-01	0.307	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.014047e-01	0.696	0	0
Syndecan interactions	R-HSA-3000170	1.396211e-01	0.855	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.403267e-01	0.853	0	0
CHL1 interactions	R-HSA-447041	4.321038e-01	0.364	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.754353e-01	0.560	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.937849e-01	0.405	0	0
Glucose metabolism	R-HSA-70326	2.237207e-01	0.650	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	4.931068e-01	0.307	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	5.264206e-01	0.279	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	5.264206e-01	0.279	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	3.964600e-01	0.402	0	0
Protein hydroxylation	R-HSA-9629569	5.006805e-01	0.300	0	0
Inflammasomes	R-HSA-622312	2.373257e-01	0.625	0	0
Signaling by TGFB family members	R-HSA-9006936	3.140755e-01	0.503	0	0
Signaling by TGFBR3	R-HSA-9839373	5.385068e-01	0.269	0	0
Signaling by KIT in disease	R-HSA-9669938	3.937849e-01	0.405	0	0
Sensory processing of sound	R-HSA-9659379	5.136744e-01	0.289	0	0
Diseases of DNA repair	R-HSA-9675135	1.776232e-01	0.751	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	4.662191e-01	0.331	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	2.663614e-01	0.575	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	3.650556e-01	0.438	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	4.375001e-01	0.359	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	4.204561e-01	0.376	0	0
Tie2 Signaling	R-HSA-210993	2.521744e-01	0.598	0	0
Interleukin-15 signaling	R-HSA-8983432	4.177110e-01	0.379	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.199045e-01	0.658	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	3.286720e-01	0.483	0	0
DSCAM interactions	R-HSA-376172	4.445841e-01	0.352	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.458726e-01	0.836	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	2.521744e-01	0.598	0	0
Synthesis of PI	R-HSA-1483226	3.389918e-01	0.470	0	0
Formation of the anterior neural plate	R-HSA-9823739	3.064414e-01	0.514	0	0
Regulation of gene expression in beta cells	R-HSA-210745	2.591255e-01	0.586	0	0
Intracellular oxygen transport	R-HSA-8981607	5.205283e-01	0.284	0	0
Signaling by ALK	R-HSA-201556	3.657616e-01	0.437	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	5.264206e-01	0.279	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.684710e-01	0.329	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	5.587993e-01	0.253	0	0
STING mediated induction of host immune responses	R-HSA-1834941	2.797455e-01	0.553	0	0
Stimuli-sensing channels	R-HSA-2672351	2.403991e-01	0.619	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	1.533925e-01	0.814	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.957258e-01	0.708	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	4.716684e-01	0.326	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	4.559597e-01	0.341	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	3.363623e-01	0.473	0	0
Insulin processing	R-HSA-264876	5.330900e-01	0.273	0	0
Nuclear import of Rev protein	R-HSA-180746	1.552634e-01	0.809	0	0
Histamine receptors	R-HSA-390650	5.205283e-01	0.284	0	0
Inositol phosphate metabolism	R-HSA-1483249	3.690529e-01	0.433	0	0
Kidney development	R-HSA-9830369	4.236458e-01	0.373	0	0
MITF-M-dependent gene expression	R-HSA-9856651	3.468956e-01	0.460	0	0
Interleukin-7 signaling	R-HSA-1266695	1.761039e-01	0.754	0	0
Interleukin-12 family signaling	R-HSA-447115	1.229525e-01	0.910	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.486648e-01	0.828	0	0
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.445841e-01	0.352	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	4.321038e-01	0.364	0	0
MECP2 regulates transcription factors	R-HSA-9022707	4.321038e-01	0.364	0	0
Metal ion SLC transporters	R-HSA-425410	2.074163e-01	0.683	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.588655e-01	0.587	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.779979e-01	0.556	0	0
Sodium/Proton exchangers	R-HSA-425986	4.805798e-01	0.318	0	0
Growth hormone receptor signaling	R-HSA-982772	4.223981e-01	0.374	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	5.349799e-01	0.272	0	0
Gap junction assembly	R-HSA-190861	5.587993e-01	0.253	0	0
Platelet sensitization by LDL	R-HSA-432142	4.375001e-01	0.359	0	0
GP1b-IX-V activation signalling	R-HSA-430116	5.264206e-01	0.279	0	0
Influenza Infection	R-HSA-168255	3.188200e-01	0.496	0	0
Maturation of nucleoprotein	R-HSA-9694631	2.797455e-01	0.553	0	0
Signaling by Leptin	R-HSA-2586552	2.992097e-01	0.524	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.286720e-01	0.483	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	3.064414e-01	0.514	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	4.321038e-01	0.364	0	0
OAS antiviral response	R-HSA-8983711	4.177110e-01	0.379	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	5.264206e-01	0.279	0	0
Interleukin-1 processing	R-HSA-448706	5.264206e-01	0.279	0	0
Nephron development	R-HSA-9831926	4.375001e-01	0.359	0	0
Maturation of nucleoprotein	R-HSA-9683610	4.559597e-01	0.341	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	5.600562e-01	0.252	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	5.605637e-01	0.251	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	5.607237e-01	0.251	0	0
Activation of SMO	R-HSA-5635838	5.633274e-01	0.249	0	0
Negative regulation of FLT3	R-HSA-9706369	5.633274e-01	0.249	0	0
Platelet homeostasis	R-HSA-418346	5.655719e-01	0.248	0	0
Regulation of CDH11 function	R-HSA-9762292	5.694407e-01	0.245	0	0
Arachidonate production from DAG	R-HSA-426048	5.694407e-01	0.245	0	0
Serotonin receptors	R-HSA-390666	5.694407e-01	0.245	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.694407e-01	0.245	0	0
LTC4-CYSLTR mediated IL4 production	R-HSA-9664535	5.694407e-01	0.245	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	5.694407e-01	0.245	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	5.750336e-01	0.240	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	5.785553e-01	0.238	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	5.802803e-01	0.236	0	0
Intra-Golgi traffic	R-HSA-6811438	5.802803e-01	0.236	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	5.826165e-01	0.235	0	0
DNA methylation	R-HSA-5334118	5.847302e-01	0.233	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	5.847302e-01	0.233	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	5.847302e-01	0.233	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	5.851101e-01	0.233	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	5.860921e-01	0.232	0	0
HCN channels	R-HSA-1296061	5.860921e-01	0.232	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	5.860921e-01	0.232	0	0
ATP sensitive Potassium channels	R-HSA-1296025	5.860921e-01	0.232	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.860921e-01	0.232	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	5.860921e-01	0.232	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.860921e-01	0.232	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	5.860921e-01	0.232	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.860921e-01	0.232	0	0
Electric Transmission Across Gap Junctions	R-HSA-112303	5.860921e-01	0.232	0	0
Transmission across Electrical Synapses	R-HSA-112307	5.860921e-01	0.232	0	0
MDK and PTN in ALK signaling	R-HSA-9851151	5.860921e-01	0.232	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.860921e-01	0.232	0	0
LDL clearance	R-HSA-8964038	5.889954e-01	0.230	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	5.889954e-01	0.230	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	5.935530e-01	0.227	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	5.940451e-01	0.226	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.961306e-01	0.225	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.961306e-01	0.225	0	0
Phase 2 - plateau phase	R-HSA-5576893	5.961306e-01	0.225	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	5.961306e-01	0.225	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	5.961306e-01	0.225	0	0
Disorders of Developmental Biology	R-HSA-9675151	5.961306e-01	0.225	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	5.988357e-01	0.223	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	5.988357e-01	0.223	0	0
HSF1 activation	R-HSA-3371511	6.046207e-01	0.219	0	0
RUNX2 regulates bone development	R-HSA-8941326	6.046207e-01	0.219	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	6.060544e-01	0.217	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.061431e-01	0.217	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	6.066438e-01	0.217	0	0
COPI-mediated anterograde transport	R-HSA-6807878	6.073145e-01	0.217	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	6.093535e-01	0.215	0	0
FGFR2b ligand binding and activation	R-HSA-190377	6.095542e-01	0.215	0	0
Formation of the posterior neural plate	R-HSA-9832991	6.095542e-01	0.215	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	6.095542e-01	0.215	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	6.113007e-01	0.214	0	0
Ub-specific processing proteases	R-HSA-5689880	6.172392e-01	0.210	0	0
DNA Repair	R-HSA-73894	6.177706e-01	0.209	0	0
Telomere Maintenance	R-HSA-157579	6.213573e-01	0.207	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	6.216988e-01	0.206	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.272809e-01	0.203	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.272809e-01	0.203	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.272809e-01	0.203	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.272809e-01	0.203	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.272809e-01	0.203	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	6.272809e-01	0.203	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	6.275181e-01	0.202	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	6.275315e-01	0.202	0	0
Cell junction organization	R-HSA-446728	6.291507e-01	0.201	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	6.331092e-01	0.199	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.351578e-01	0.197	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.351578e-01	0.197	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.351578e-01	0.197	0	0
Ion channel transport	R-HSA-983712	6.375315e-01	0.195	0	0
PKR-mediated signaling	R-HSA-9833482	6.407731e-01	0.193	0	0
G1 Phase	R-HSA-69236	6.415373e-01	0.193	0	0
Cyclin D associated events in G1	R-HSA-69231	6.415373e-01	0.193	0	0
Gap junction trafficking	R-HSA-190828	6.415373e-01	0.193	0	0
Complex III assembly	R-HSA-9865881	6.424753e-01	0.192	0	0
Interleukin-6 family signaling	R-HSA-6783589	6.424753e-01	0.192	0	0
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	6.426939e-01	0.192	0	0
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	6.426939e-01	0.192	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	6.426939e-01	0.192	0	0
PTK6 Down-Regulation	R-HSA-8849472	6.426939e-01	0.192	0	0
Activation of AKT2	R-HSA-165158	6.426939e-01	0.192	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	6.426939e-01	0.192	0	0
Activation of C3 and C5	R-HSA-174577	6.426939e-01	0.192	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	6.426939e-01	0.192	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	6.426939e-01	0.192	0	0
Inositol transporters	R-HSA-429593	6.426939e-01	0.192	0	0
Co-inhibition by BTLA	R-HSA-9927353	6.426939e-01	0.192	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	6.426939e-01	0.192	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	6.467516e-01	0.189	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	6.467516e-01	0.189	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	6.467516e-01	0.189	0	0
ERKs are inactivated	R-HSA-202670	6.467516e-01	0.189	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	6.467516e-01	0.189	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	6.467516e-01	0.189	0	0
NF-kB is activated and signals survival	R-HSA-209560	6.467516e-01	0.189	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	6.467516e-01	0.189	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	6.467516e-01	0.189	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.477165e-01	0.189	0	0
Regulation of beta-cell development	R-HSA-186712	6.503028e-01	0.187	0	0
Gastrulation	R-HSA-9758941	6.508318e-01	0.187	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	6.549546e-01	0.184	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	6.559588e-01	0.183	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	6.559588e-01	0.183	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	6.567334e-01	0.183	0	0
PKA activation in glucagon signalling	R-HSA-164378	6.567334e-01	0.183	0	0
Mismatch Repair	R-HSA-5358508	6.567334e-01	0.183	0	0
GAB1 signalosome	R-HSA-180292	6.567334e-01	0.183	0	0
PKA activation	R-HSA-163615	6.567334e-01	0.183	0	0
FGFR1 ligand binding and activation	R-HSA-190242	6.567334e-01	0.183	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.567334e-01	0.183	0	0
Signaling by NOTCH	R-HSA-157118	6.634179e-01	0.178	0	0
G1/S Transition	R-HSA-69206	6.668116e-01	0.176	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	6.674328e-01	0.176	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	6.674328e-01	0.176	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	6.674328e-01	0.176	0	0
TGFBR3 expression	R-HSA-9839394	6.674328e-01	0.176	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	6.681578e-01	0.175	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.702893e-01	0.174	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	6.726014e-01	0.172	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	6.726014e-01	0.172	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.726014e-01	0.172	0	0
Ribosome-associated quality control	R-HSA-9948299	6.750223e-01	0.171	0	0
Cardiogenesis	R-HSA-9733709	6.778742e-01	0.169	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	6.793397e-01	0.168	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	6.793397e-01	0.168	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	6.793397e-01	0.168	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	6.810803e-01	0.167	0	0
IRAK1 recruits IKK complex	R-HSA-937039	6.810803e-01	0.167	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.810803e-01	0.167	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	6.810803e-01	0.167	0	0
Scavenging by Class F Receptors	R-HSA-3000484	6.810803e-01	0.167	0	0
p75NTR recruits signalling complexes	R-HSA-209543	6.810803e-01	0.167	0	0
GRB2 events in EGFR signaling	R-HSA-179812	6.810803e-01	0.167	0	0
MET activates RAS signaling	R-HSA-8851805	6.810803e-01	0.167	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	6.810803e-01	0.167	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	6.810803e-01	0.167	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	6.810803e-01	0.167	0	0
Interleukin-1 family signaling	R-HSA-446652	6.827756e-01	0.166	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	6.844704e-01	0.165	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.844704e-01	0.165	0	0
Regulation of signaling by CBL	R-HSA-912631	6.844704e-01	0.165	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.844704e-01	0.165	0	0
Other interleukin signaling	R-HSA-449836	6.844704e-01	0.165	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.849581e-01	0.164	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.849581e-01	0.164	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.877023e-01	0.163	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.878304e-01	0.163	0	0
Generation of second messenger molecules	R-HSA-202433	6.878304e-01	0.163	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.887005e-01	0.162	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	6.911678e-01	0.160	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	6.911678e-01	0.160	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.915582e-01	0.160	0	0
PKB-mediated events	R-HSA-109703	6.915582e-01	0.160	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.915582e-01	0.160	0	0
PDE3B signalling	R-HSA-165160	6.915582e-01	0.160	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.915582e-01	0.160	0	0
Signaling by RNF43 mutants	R-HSA-5340588	6.915582e-01	0.160	0	0
Defective CSF2RA causes SMDP4	R-HSA-5688890	6.915582e-01	0.160	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.915582e-01	0.160	0	0
Defective CSF2RB causes SMDP5	R-HSA-5688849	6.915582e-01	0.160	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	6.915582e-01	0.160	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.915582e-01	0.160	0	0
NGF-independant TRKA activation	R-HSA-187024	6.915582e-01	0.160	0	0
Pentose phosphate pathway disease	R-HSA-6791465	6.915582e-01	0.160	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	6.915582e-01	0.160	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.915582e-01	0.160	0	0
Phosphorylation of Emi1	R-HSA-176417	6.915582e-01	0.160	0	0
Formation of the Editosome	R-HSA-75094	6.915582e-01	0.160	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.915582e-01	0.160	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	6.915582e-01	0.160	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	6.915582e-01	0.160	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.915582e-01	0.160	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.915582e-01	0.160	0	0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	6.915582e-01	0.160	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.915582e-01	0.160	0	0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	6.915582e-01	0.160	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.915582e-01	0.160	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.970849e-01	0.157	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	6.988367e-01	0.156	0	0
Miscellaneous transport and binding events	R-HSA-5223345	6.988367e-01	0.156	0	0
Signaling by PDGF	R-HSA-186797	6.993340e-01	0.155	0	0
tRNA processing in the nucleus	R-HSA-6784531	6.993340e-01	0.155	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.035746e-01	0.153	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	7.038099e-01	0.153	0	0
HDACs deacetylate histones	R-HSA-3214815	7.062001e-01	0.151	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	7.067194e-01	0.151	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	7.067194e-01	0.151	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	7.083790e-01	0.150	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	7.104970e-01	0.148	0	0
Signal transduction by L1	R-HSA-445144	7.104970e-01	0.148	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	7.126292e-01	0.147	0	0
FGFR2c ligand binding and activation	R-HSA-190375	7.126292e-01	0.147	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	7.126292e-01	0.147	0	0
FGFR4 ligand binding and activation	R-HSA-190322	7.126292e-01	0.147	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	7.126292e-01	0.147	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	7.126292e-01	0.147	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	7.126292e-01	0.147	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	7.136718e-01	0.147	0	0
Packaging Of Telomere Ends	R-HSA-171306	7.136718e-01	0.147	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	7.136718e-01	0.147	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	7.150892e-01	0.146	0	0
RNA Polymerase I Transcription	R-HSA-73864	7.169001e-01	0.145	0	0
PCP/CE pathway	R-HSA-4086400	7.169001e-01	0.145	0	0
Cellular response to chemical stress	R-HSA-9711123	7.184612e-01	0.144	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	7.188363e-01	0.143	0	0
Dual Incision in GG-NER	R-HSA-5696400	7.188363e-01	0.143	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	7.188363e-01	0.143	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	7.188363e-01	0.143	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	7.221295e-01	0.141	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	7.227150e-01	0.141	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	7.248156e-01	0.140	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	7.248156e-01	0.140	0	0
Ion transport by P-type ATPases	R-HSA-936837	7.294880e-01	0.137	0	0
Integration of energy metabolism	R-HSA-163685	7.298894e-01	0.137	0	0
Gap junction trafficking and regulation	R-HSA-157858	7.311068e-01	0.136	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	7.337424e-01	0.134	0	0
Erythropoietin activates STAT5	R-HSA-9027283	7.337424e-01	0.134	0	0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	7.337424e-01	0.134	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	7.337424e-01	0.134	0	0
Hydrolysis of LPE	R-HSA-1483152	7.337424e-01	0.134	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	7.337424e-01	0.134	0	0
Neurofascin interactions	R-HSA-447043	7.337424e-01	0.134	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	7.337424e-01	0.134	0	0
Signaling by LTK in cancer	R-HSA-9842640	7.337424e-01	0.134	0	0
VLDL assembly	R-HSA-8866423	7.337424e-01	0.134	0	0
Lipid particle organization	R-HSA-8964572	7.337424e-01	0.134	0	0
Signalling to RAS	R-HSA-167044	7.348371e-01	0.134	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.348371e-01	0.134	0	0
ERK/MAPK targets	R-HSA-198753	7.348371e-01	0.134	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.348371e-01	0.134	0	0
Basigin interactions	R-HSA-210991	7.348371e-01	0.134	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	7.348371e-01	0.134	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.348371e-01	0.134	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	7.349480e-01	0.134	0	0
Pyroptosis	R-HSA-5620971	7.349480e-01	0.134	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	7.365834e-01	0.133	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	7.376713e-01	0.132	0	0
SARS-CoV-2 Infection	R-HSA-9694516	7.384085e-01	0.132	0	0
Co-inhibition by PD-1	R-HSA-389948	7.384298e-01	0.132	0	0
Prolactin receptor signaling	R-HSA-1170546	7.415164e-01	0.130	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	7.415164e-01	0.130	0	0
Removal of the Flap Intermediate	R-HSA-69166	7.415164e-01	0.130	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	7.415164e-01	0.130	0	0
FGFR3c ligand binding and activation	R-HSA-190372	7.415164e-01	0.130	0	0
Physiological factors	R-HSA-5578768	7.415164e-01	0.130	0	0
Signal regulatory protein family interactions	R-HSA-391160	7.415164e-01	0.130	0	0
Zinc transporters	R-HSA-435354	7.415164e-01	0.130	0	0
P2Y receptors	R-HSA-417957	7.415164e-01	0.130	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.421154e-01	0.130	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	7.421154e-01	0.130	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	7.421154e-01	0.130	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.427681e-01	0.129	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.434156e-01	0.129	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	7.470109e-01	0.127	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	7.495926e-01	0.125	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	7.550093e-01	0.122	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	7.559438e-01	0.122	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	7.559438e-01	0.122	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	7.560308e-01	0.121	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	7.575297e-01	0.121	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	7.575297e-01	0.121	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.575297e-01	0.121	0	0
Assembly Of The HIV Virion	R-HSA-175474	7.575297e-01	0.121	0	0
Platelet degranulation	R-HSA-114608	7.659146e-01	0.116	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	7.663724e-01	0.116	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	7.678797e-01	0.115	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	7.678797e-01	0.115	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	7.678797e-01	0.115	0	0
FGFR3 ligand binding and activation	R-HSA-190239	7.678797e-01	0.115	0	0
p38MAPK events	R-HSA-171007	7.678797e-01	0.115	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	7.678797e-01	0.115	0	0
Chromosome Maintenance	R-HSA-73886	7.697624e-01	0.114	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	7.701594e-01	0.113	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.701594e-01	0.113	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	7.701594e-01	0.113	0	0
Recycling of eIF2:GDP	R-HSA-72731	7.701594e-01	0.113	0	0
FGFR3b ligand binding and activation	R-HSA-190371	7.701594e-01	0.113	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.701594e-01	0.113	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	7.701594e-01	0.113	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	7.701594e-01	0.113	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	7.701594e-01	0.113	0	0
LDL remodeling	R-HSA-8964041	7.701594e-01	0.113	0	0
VLDL clearance	R-HSA-8964046	7.701594e-01	0.113	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	7.701594e-01	0.113	0	0
Activation of TRKA receptors	R-HSA-187015	7.701594e-01	0.113	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	7.701594e-01	0.113	0	0
Maturation of replicase proteins	R-HSA-9694301	7.701594e-01	0.113	0	0
Degradation of AXIN	R-HSA-4641257	7.730664e-01	0.112	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	7.730664e-01	0.112	0	0
Cleavage of the damaged purine	R-HSA-110331	7.730664e-01	0.112	0	0
DAP12 interactions	R-HSA-2172127	7.743347e-01	0.111	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.753530e-01	0.111	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	7.767856e-01	0.110	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	7.767856e-01	0.110	0	0
Adaptive Immune System	R-HSA-1280218	7.784528e-01	0.109	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	7.786261e-01	0.109	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	7.799367e-01	0.108	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	7.891592e-01	0.103	0	0
Depurination	R-HSA-73927	7.892539e-01	0.103	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	7.892692e-01	0.103	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	7.892692e-01	0.103	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	7.915808e-01	0.102	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	7.918691e-01	0.101	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	7.918691e-01	0.101	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	7.918691e-01	0.101	0	0
Differentiation of T cells	R-HSA-9945266	7.918691e-01	0.101	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	7.918691e-01	0.101	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	7.918691e-01	0.101	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.918691e-01	0.101	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.918691e-01	0.101	0	0
MAP kinase activation	R-HSA-450294	7.929150e-01	0.101	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	7.936752e-01	0.100	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	7.953233e-01	0.099	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.981863e-01	0.098	0	0
Interleukin-20 family signaling	R-HSA-8854691	7.981863e-01	0.098	0	0
Carnitine shuttle	R-HSA-200425	7.981863e-01	0.098	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	8.015972e-01	0.096	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	8.015972e-01	0.096	0	0
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	8.015972e-01	0.096	0	0
MET receptor recycling	R-HSA-8875656	8.015972e-01	0.096	0	0
Formation of annular gap junctions	R-HSA-196025	8.015972e-01	0.096	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	8.015972e-01	0.096	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	8.015972e-01	0.096	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	8.015972e-01	0.096	0	0
Activation of RAS in B cells	R-HSA-1169092	8.015972e-01	0.096	0	0
Fructose biosynthesis	R-HSA-5652227	8.015972e-01	0.096	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	8.015972e-01	0.096	0	0
Nucleotide salvage defects	R-HSA-9734207	8.015972e-01	0.096	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	8.015972e-01	0.096	0	0
Interleukin-23 signaling	R-HSA-9020933	8.015972e-01	0.096	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	8.021886e-01	0.096	0	0
Mitochondrial biogenesis	R-HSA-1592230	8.024700e-01	0.096	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.034364e-01	0.095	0	0
Mitochondrial protein import	R-HSA-1268020	8.053140e-01	0.094	0	0
IRE1alpha activates chaperones	R-HSA-381070	8.056723e-01	0.094	0	0
Vesicle-mediated transport	R-HSA-5653656	8.070254e-01	0.093	0	0
DNA strand elongation	R-HSA-69190	8.081538e-01	0.093	0	0
Nucleotide Excision Repair	R-HSA-5696398	8.128214e-01	0.090	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	8.136407e-01	0.090	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	8.136407e-01	0.090	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.136407e-01	0.090	0	0
Galactose catabolism	R-HSA-70370	8.136407e-01	0.090	0	0
tRNA modification in the mitochondrion	R-HSA-6787450	8.136407e-01	0.090	0	0
Synthesis of PG	R-HSA-1483148	8.136407e-01	0.090	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.162774e-01	0.088	0	0
Deadenylation of mRNA	R-HSA-429947	8.162774e-01	0.088	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	8.162774e-01	0.088	0	0
Interferon Signaling	R-HSA-913531	8.163157e-01	0.088	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	8.168520e-01	0.088	0	0
Regulation of mitotic cell cycle	R-HSA-453276	8.185537e-01	0.087	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	8.185537e-01	0.087	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.189077e-01	0.087	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	8.189077e-01	0.087	0	0
Diseases of Immune System	R-HSA-5260271	8.189077e-01	0.087	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.189077e-01	0.087	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.199957e-01	0.086	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.199957e-01	0.086	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	8.218932e-01	0.085	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.227165e-01	0.085	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.283920e-01	0.082	0	0
Gap junction degradation	R-HSA-190873	8.287366e-01	0.082	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	8.287366e-01	0.082	0	0
p75NTR regulates axonogenesis	R-HSA-193697	8.287366e-01	0.082	0	0
MAPK1 (ERK2) activation	R-HSA-112411	8.287366e-01	0.082	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	8.287366e-01	0.082	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	8.287366e-01	0.082	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	8.287366e-01	0.082	0	0
GPER1 signaling	R-HSA-9634597	8.295345e-01	0.081	0	0
Intraflagellar transport	R-HSA-5620924	8.295345e-01	0.081	0	0
Gene Silencing by RNA	R-HSA-211000	8.306352e-01	0.081	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.324246e-01	0.080	0	0
G protein gated Potassium channels	R-HSA-1296059	8.329712e-01	0.079	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	8.329712e-01	0.079	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.329712e-01	0.079	0	0
Tight junction interactions	R-HSA-420029	8.329712e-01	0.079	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	8.333521e-01	0.079	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.333521e-01	0.079	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	8.333521e-01	0.079	0	0
Interleukin-1 signaling	R-HSA-9020702	8.366576e-01	0.077	0	0
Degradation of CDH1	R-HSA-9766229	8.415043e-01	0.075	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	8.415455e-01	0.075	1	1
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.441063e-01	0.074	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.441063e-01	0.074	0	0
Regulation of endogenous retroelements	R-HSA-9842860	8.451030e-01	0.073	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.451065e-01	0.073	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.451065e-01	0.073	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.451065e-01	0.073	0	0
HIV Transcription Initiation	R-HSA-167161	8.451065e-01	0.073	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.451065e-01	0.073	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.483423e-01	0.071	0	0
Dual incision in TC-NER	R-HSA-6782135	8.504181e-01	0.070	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.504893e-01	0.070	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	8.511597e-01	0.070	0	0
Activated point mutants of FGFR2	R-HSA-2033519	8.511597e-01	0.070	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	8.511597e-01	0.070	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	8.511597e-01	0.070	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	8.511597e-01	0.070	0	0
Mitophagy	R-HSA-5205647	8.514972e-01	0.070	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	8.514972e-01	0.070	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.514972e-01	0.070	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	8.521649e-01	0.069	0	0
DNA replication initiation	R-HSA-68952	8.521649e-01	0.069	0	0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	8.521649e-01	0.069	0	0
Pexophagy	R-HSA-9664873	8.521649e-01	0.069	0	0
Binding and entry of HIV virion	R-HSA-173107	8.521649e-01	0.069	0	0
2-LTR circle formation	R-HSA-164843	8.521649e-01	0.069	0	0
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.521649e-01	0.069	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	8.521649e-01	0.069	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	8.521649e-01	0.069	0	0
Interleukin-27 signaling	R-HSA-9020956	8.521649e-01	0.069	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.521649e-01	0.069	0	0
MAPK3 (ERK1) activation	R-HSA-110056	8.521649e-01	0.069	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.521649e-01	0.069	0	0
Josephin domain DUBs	R-HSA-5689877	8.521649e-01	0.069	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	8.569845e-01	0.067	0	0
Depyrimidination	R-HSA-73928	8.569845e-01	0.067	0	0
Protein ubiquitination	R-HSA-8852135	8.583256e-01	0.066	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.583256e-01	0.066	0	0
Cytoprotection by HMOX1	R-HSA-9707564	8.583515e-01	0.066	0	0
Downstream TCR signaling	R-HSA-202424	8.588799e-01	0.066	0	0
Cristae formation	R-HSA-8949613	8.624669e-01	0.064	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.624669e-01	0.064	0	0
Maturation of hRSV A proteins	R-HSA-9828806	8.624669e-01	0.064	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	8.633964e-01	0.064	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	8.633964e-01	0.064	0	0
PERK regulates gene expression	R-HSA-381042	8.639691e-01	0.064	0	0
Oncogene Induced Senescence	R-HSA-2559585	8.639691e-01	0.064	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	8.667588e-01	0.062	0	0
Adherens junctions interactions	R-HSA-418990	8.669973e-01	0.062	0	0
Translesion Synthesis by POLH	R-HSA-110320	8.672152e-01	0.062	0	0
Pyrimidine biosynthesis	R-HSA-500753	8.672152e-01	0.062	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	8.680914e-01	0.061	0	0
GABA receptor activation	R-HSA-977443	8.701021e-01	0.060	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.701021e-01	0.060	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.723895e-01	0.059	0	0
vRNA Synthesis	R-HSA-192814	8.723895e-01	0.059	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.723895e-01	0.059	0	0
vRNP Assembly	R-HSA-192905	8.723895e-01	0.059	0	0
Chylomicron assembly	R-HSA-8963888	8.723895e-01	0.059	0	0
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	8.723895e-01	0.059	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.723895e-01	0.059	0	0
LGI-ADAM interactions	R-HSA-5682910	8.723895e-01	0.059	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.723895e-01	0.059	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.723895e-01	0.059	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	8.723895e-01	0.059	0	0
Transport of RCbl within the body	R-HSA-9758890	8.723895e-01	0.059	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	8.733671e-01	0.059	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	8.733671e-01	0.059	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.754214e-01	0.058	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.755320e-01	0.058	0	0
RNA Polymerase III Transcription	R-HSA-74158	8.755320e-01	0.058	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.755320e-01	0.058	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	8.755320e-01	0.058	0	0
Toll-like Receptor Cascades	R-HSA-168898	8.781935e-01	0.056	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.791137e-01	0.056	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	8.816646e-01	0.055	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.816646e-01	0.055	0	0
Acyl chain remodelling of PI	R-HSA-1482922	8.816646e-01	0.055	0	0
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.816646e-01	0.055	0	0
Pregnenolone biosynthesis	R-HSA-196108	8.816646e-01	0.055	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	8.816646e-01	0.055	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	8.816646e-01	0.055	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.827213e-01	0.054	0	0
Neutrophil degranulation	R-HSA-6798695	8.831645e-01	0.054	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	8.833189e-01	0.054	0	0
PPARA activates gene expression	R-HSA-1989781	8.846541e-01	0.053	0	0
Interleukin-17 signaling	R-HSA-448424	8.849854e-01	0.053	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	8.862342e-01	0.052	0	0
mRNA Capping	R-HSA-72086	8.872813e-01	0.052	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	8.872813e-01	0.052	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	8.872813e-01	0.052	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.875986e-01	0.052	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.881271e-01	0.052	0	0
Assembly of the pre-replicative complex	R-HSA-68867	8.889519e-01	0.051	0	0
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.898482e-01	0.051	0	0
PI3K events in ERBB4 signaling	R-HSA-1250342	8.898482e-01	0.051	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.898482e-01	0.051	0	0
Plasmalogen biosynthesis	R-HSA-75896	8.898482e-01	0.051	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	8.898482e-01	0.051	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.898482e-01	0.051	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.898482e-01	0.051	0	0
Integration of provirus	R-HSA-162592	8.898482e-01	0.051	0	0
Translation initiation complex formation	R-HSA-72649	8.914851e-01	0.050	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.914851e-01	0.050	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.914851e-01	0.050	0	0
FGFR2 ligand binding and activation	R-HSA-190241	8.946470e-01	0.048	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	8.946470e-01	0.048	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.952101e-01	0.048	0	0
Mitochondrial protein degradation	R-HSA-9837999	8.955904e-01	0.048	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.961240e-01	0.048	0	0
MET promotes cell motility	R-HSA-8875878	8.961240e-01	0.048	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	8.971248e-01	0.047	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	8.971248e-01	0.047	0	0
Activation of the pre-replicative complex	R-HSA-68962	8.981209e-01	0.047	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.981209e-01	0.047	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.981209e-01	0.047	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.996849e-01	0.046	0	0
DNA Replication Pre-Initiation	R-HSA-69002	9.010315e-01	0.045	0	0
HCMV Early Events	R-HSA-9609690	9.021093e-01	0.045	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	9.049193e-01	0.043	0	0
Interleukin-35 Signalling	R-HSA-8984722	9.049193e-01	0.043	0	0
Diseases associated with surfactant metabolism	R-HSA-5687613	9.049193e-01	0.043	0	0
Pervasive developmental disorders	R-HSA-9005895	9.049193e-01	0.043	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	9.049193e-01	0.043	0	0
Disorders of Nervous System Development	R-HSA-9697154	9.049193e-01	0.043	0	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	9.049193e-01	0.043	0	0
Estrogen biosynthesis	R-HSA-193144	9.049193e-01	0.043	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	9.049193e-01	0.043	0	0
Stabilization of p53	R-HSA-69541	9.052492e-01	0.043	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.052492e-01	0.043	0	0
Pentose phosphate pathway	R-HSA-71336	9.052492e-01	0.043	0	0
Plasma lipoprotein clearance	R-HSA-8964043	9.052492e-01	0.043	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.054883e-01	0.043	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.054883e-01	0.043	0	0
Synthesis of PC	R-HSA-1483191	9.054883e-01	0.043	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.062930e-01	0.043	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	9.062930e-01	0.043	0	0
Glutathione synthesis and recycling	R-HSA-174403	9.062930e-01	0.043	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	9.062930e-01	0.043	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	9.073469e-01	0.042	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.073469e-01	0.042	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.080122e-01	0.042	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.080122e-01	0.042	0	0
SARS-CoV-1 Infection	R-HSA-9678108	9.114201e-01	0.040	0	0
Adipogenesis	R-HSA-9843745	9.119158e-01	0.040	0	0
Cell-cell junction organization	R-HSA-421270	9.123102e-01	0.040	0	0
Signaling by NOTCH4	R-HSA-9013694	9.133474e-01	0.039	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	9.136565e-01	0.039	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.136565e-01	0.039	0	0
Glycogen metabolism	R-HSA-8982491	9.136565e-01	0.039	0	0
Regulation of CDH1 Function	R-HSA-9764561	9.144976e-01	0.039	0	0
Base Excision Repair	R-HSA-73884	9.149330e-01	0.039	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	9.167254e-01	0.038	0	0
Fructose metabolism	R-HSA-5652084	9.167254e-01	0.038	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.167254e-01	0.038	0	0
Acetylcholine binding and downstream events	R-HSA-181431	9.179290e-01	0.037	0	0
Adenylate cyclase activating pathway	R-HSA-170660	9.179290e-01	0.037	0	0
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	9.179290e-01	0.037	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	9.179290e-01	0.037	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	9.179290e-01	0.037	0	0
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	9.179290e-01	0.037	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	9.179290e-01	0.037	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	9.179290e-01	0.037	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	9.179290e-01	0.037	0	0
Diseases of nucleotide metabolism	R-HSA-9735804	9.179290e-01	0.037	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	9.179290e-01	0.037	0	0
DNA Damage Bypass	R-HSA-73893	9.204489e-01	0.036	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	9.211631e-01	0.036	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.211631e-01	0.036	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.211631e-01	0.036	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.213916e-01	0.036	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.213916e-01	0.036	0	0
Regulation of insulin secretion	R-HSA-422356	9.240424e-01	0.034	0	0
UCH proteinases	R-HSA-5689603	9.251313e-01	0.034	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	9.252239e-01	0.034	0	0
rRNA processing	R-HSA-72312	9.259080e-01	0.033	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.260581e-01	0.033	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.260581e-01	0.033	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.260581e-01	0.033	0	0
Developmental Cell Lineages	R-HSA-9734767	9.269186e-01	0.033	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.273688e-01	0.033	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.284988e-01	0.032	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	9.291593e-01	0.032	0	0
Transport of fatty acids	R-HSA-804914	9.291593e-01	0.032	0	0
Hydrolysis of LPC	R-HSA-1483115	9.291593e-01	0.032	0	0
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	9.291593e-01	0.032	0	0
Glycerophospholipid catabolism	R-HSA-6814848	9.291593e-01	0.032	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	9.291593e-01	0.032	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.291593e-01	0.032	0	0
HDL assembly	R-HSA-8963896	9.291593e-01	0.032	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	9.291593e-01	0.032	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	9.291593e-01	0.032	0	0
Translation of Structural Proteins	R-HSA-9694635	9.304846e-01	0.031	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	9.326738e-01	0.030	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.326738e-01	0.030	0	0
Heme degradation	R-HSA-189483	9.326738e-01	0.030	0	0
RAB geranylgeranylation	R-HSA-8873719	9.331400e-01	0.030	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.343967e-01	0.029	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.343967e-01	0.029	0	0
Plasma lipoprotein assembly	R-HSA-8963898	9.343967e-01	0.029	0	0
TNFs bind their physiological receptors	R-HSA-5669034	9.343967e-01	0.029	0	0
Hemostasis	R-HSA-109582	9.347039e-01	0.029	0	0
Activation of GABAB receptors	R-HSA-991365	9.350206e-01	0.029	0	0
GABA B receptor activation	R-HSA-977444	9.350206e-01	0.029	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.388535e-01	0.027	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	9.388535e-01	0.027	0	0
Translesion synthesis by REV1	R-HSA-110312	9.388535e-01	0.027	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	9.388535e-01	0.027	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	9.388535e-01	0.027	0	0
Biotin transport and metabolism	R-HSA-196780	9.388535e-01	0.027	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	9.388535e-01	0.027	0	0
Other semaphorin interactions	R-HSA-416700	9.388535e-01	0.027	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	9.388535e-01	0.027	0	0
DNA Damage Reversal	R-HSA-73942	9.388535e-01	0.027	0	0
eNOS activation	R-HSA-203615	9.394340e-01	0.027	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.394340e-01	0.027	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.394340e-01	0.027	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.407688e-01	0.027	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.409979e-01	0.026	0	0
Laminin interactions	R-HSA-3000157	9.418384e-01	0.026	0	0
Amino acids regulate mTORC1	R-HSA-9639288	9.442177e-01	0.025	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.455608e-01	0.024	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.464696e-01	0.024	0	0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	R-HSA-2142816	9.472215e-01	0.024	0	0
Translesion synthesis by POLI	R-HSA-5656121	9.472215e-01	0.024	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.472215e-01	0.024	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	9.472215e-01	0.024	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	9.472215e-01	0.024	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	9.472215e-01	0.024	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.472215e-01	0.024	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	9.472215e-01	0.024	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.472215e-01	0.024	0	0
Fructose catabolism	R-HSA-70350	9.472215e-01	0.024	0	0
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	9.472215e-01	0.024	0	0
Attachment and Entry	R-HSA-9678110	9.472215e-01	0.024	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	9.473562e-01	0.023	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.484725e-01	0.023	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.484725e-01	0.023	0	0
Amyloid fiber formation	R-HSA-977225	9.486974e-01	0.023	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.490572e-01	0.023	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	9.499005e-01	0.022	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.514728e-01	0.022	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.514728e-01	0.022	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.514728e-01	0.022	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	9.514728e-01	0.022	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.514728e-01	0.022	0	0
Fanconi Anemia Pathway	R-HSA-6783310	9.514728e-01	0.022	0	0
G alpha (s) signalling events	R-HSA-418555	9.518616e-01	0.021	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.520507e-01	0.021	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.542445e-01	0.020	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.543807e-01	0.020	0	0
Triglyceride biosynthesis	R-HSA-75109	9.543807e-01	0.020	0	0
Synthesis of PE	R-HSA-1483213	9.543807e-01	0.020	0	0
Signaling by BMP	R-HSA-201451	9.543807e-01	0.020	0	0
Translesion synthesis by POLK	R-HSA-5655862	9.544448e-01	0.020	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.544448e-01	0.020	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.544448e-01	0.020	0	0
Formation of xylulose-5-phosphate	R-HSA-5661270	9.544448e-01	0.020	0	0
Coenzyme A biosynthesis	R-HSA-196783	9.544448e-01	0.020	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.560426e-01	0.020	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.561221e-01	0.019	0	0
Degradation of DVL	R-HSA-4641258	9.561221e-01	0.019	0	0
Cellular response to hypoxia	R-HSA-1234174	9.563092e-01	0.019	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.596372e-01	0.018	0	0
Pyrimidine salvage	R-HSA-73614	9.596372e-01	0.018	0	0
Elastic fibre formation	R-HSA-1566948	9.606520e-01	0.017	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.606799e-01	0.017	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	9.606799e-01	0.017	0	0
Catecholamine biosynthesis	R-HSA-209905	9.606799e-01	0.017	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.606799e-01	0.017	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.628099e-01	0.016	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.628510e-01	0.016	0	0
Gluconeogenesis	R-HSA-70263	9.640124e-01	0.016	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	9.640124e-01	0.016	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.643099e-01	0.016	0	0
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.643099e-01	0.016	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.643099e-01	0.016	0	0
RAS processing	R-HSA-9648002	9.647395e-01	0.016	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.647395e-01	0.016	0	0
DNA Replication	R-HSA-69306	9.650089e-01	0.015	0	0
Protein localization	R-HSA-9609507	9.650089e-01	0.015	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.654302e-01	0.015	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	9.660618e-01	0.015	0	0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	R-HSA-2142670	9.660618e-01	0.015	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	9.660618e-01	0.015	0	0
Collagen formation	R-HSA-1474290	9.681747e-01	0.014	0	0
HCMV Infection	R-HSA-9609646	9.684102e-01	0.014	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.684243e-01	0.014	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.684243e-01	0.014	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.684243e-01	0.014	0	0
Cholesterol biosynthesis	R-HSA-191273	9.684461e-01	0.014	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.684599e-01	0.014	0	0
GPCR downstream signalling	R-HSA-388396	9.695135e-01	0.013	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	9.698503e-01	0.013	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.707074e-01	0.013	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.707074e-01	0.013	0	0
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.707074e-01	0.013	0	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.707074e-01	0.013	0	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.707074e-01	0.013	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.707074e-01	0.013	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.717429e-01	0.012	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.717429e-01	0.012	0	0
Maturation of spike protein	R-HSA-9694548	9.717429e-01	0.012	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.719502e-01	0.012	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.721429e-01	0.012	0	0
HCMV Late Events	R-HSA-9610379	9.726993e-01	0.012	0	0
The phototransduction cascade	R-HSA-2514856	9.734824e-01	0.012	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.735570e-01	0.012	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.743694e-01	0.011	0	0
SARS-CoV Infections	R-HSA-9679506	9.744058e-01	0.011	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.747173e-01	0.011	0	0
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.747173e-01	0.011	0	0
Signaling by NODAL	R-HSA-1181150	9.747173e-01	0.011	0	0
Glycogen synthesis	R-HSA-3322077	9.747173e-01	0.011	0	0
Translation of Structural Proteins	R-HSA-9683701	9.747290e-01	0.011	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.748374e-01	0.011	0	0
Potential therapeutics for SARS	R-HSA-9679191	9.750576e-01	0.011	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.754088e-01	0.011	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.759868e-01	0.011	0	0
G alpha (q) signalling events	R-HSA-416476	9.767518e-01	0.010	0	0
Neurotransmitter release cycle	R-HSA-112310	9.770617e-01	0.010	0	0
G-protein activation	R-HSA-202040	9.781785e-01	0.010	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.781785e-01	0.010	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.781785e-01	0.010	0	0
Switching of origins to a post-replicative state	R-HSA-69052	9.786652e-01	0.009	0	0
Synthesis of DNA	R-HSA-69239	9.801446e-01	0.009	0	0
Vpu mediated degradation of CD4	R-HSA-180534	9.808657e-01	0.008	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	9.808657e-01	0.008	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.811661e-01	0.008	0	0
Serine metabolism	R-HSA-977347	9.811661e-01	0.008	0	0
Attachment and Entry	R-HSA-9694614	9.811661e-01	0.008	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.818074e-01	0.008	0	0
Proteasome assembly	R-HSA-9907900	9.819898e-01	0.008	0	0
Surfactant metabolism	R-HSA-5683826	9.819898e-01	0.008	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.822764e-01	0.008	0	0
G alpha (z) signalling events	R-HSA-418597	9.825110e-01	0.008	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.831336e-01	0.007	0	0
Signal amplification	R-HSA-392518	9.831336e-01	0.007	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.831336e-01	0.007	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.831336e-01	0.007	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.837447e-01	0.007	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.837447e-01	0.007	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.837447e-01	0.007	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.837447e-01	0.007	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.837695e-01	0.007	0	0
Nucleosome assembly	R-HSA-774815	9.839313e-01	0.007	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	9.839313e-01	0.007	0	0
Somitogenesis	R-HSA-9824272	9.839313e-01	0.007	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.842632e-01	0.007	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.847250e-01	0.007	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.851393e-01	0.007	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.851393e-01	0.007	0	0
Regulation of Apoptosis	R-HSA-169911	9.851393e-01	0.007	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.853053e-01	0.006	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.856713e-01	0.006	0	0
Synthesis of PA	R-HSA-1483166	9.858479e-01	0.006	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.859704e-01	0.006	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.859704e-01	0.006	0	0
Biosynthesis of maresins	R-HSA-9018682	9.859704e-01	0.006	0	0
Formation of the ureteric bud	R-HSA-9830674	9.859704e-01	0.006	0	0
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.859704e-01	0.006	0	0
ABC transporters in lipid homeostasis	R-HSA-1369062	9.859704e-01	0.006	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.859704e-01	0.006	0	0
Interferon gamma signaling	R-HSA-877300	9.863362e-01	0.006	0	0
CYP2E1 reactions	R-HSA-211999	9.878915e-01	0.005	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.878915e-01	0.005	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.878915e-01	0.005	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.878915e-01	0.005	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.878915e-01	0.005	0	0
Mitochondrial RNA degradation	R-HSA-9836573	9.878915e-01	0.005	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.884783e-01	0.005	0	0
NCAM1 interactions	R-HSA-419037	9.884783e-01	0.005	0	0
Collagen chain trimerization	R-HSA-8948216	9.884783e-01	0.005	0	0
Peroxisomal protein import	R-HSA-9033241	9.885736e-01	0.005	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.885736e-01	0.005	0	0
Viral Infection Pathways	R-HSA-9824446	9.894775e-01	0.005	0	0
Alpha-oxidation of phytanate	R-HSA-389599	9.895497e-01	0.005	0	0
Acyl chain remodelling of PS	R-HSA-1482801	9.895497e-01	0.005	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.895497e-01	0.005	0	0
Purine salvage	R-HSA-74217	9.898610e-01	0.004	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.898718e-01	0.004	0	0
Collagen degradation	R-HSA-1442490	9.907939e-01	0.004	0	0
Aquaporin-mediated transport	R-HSA-445717	9.907939e-01	0.004	0	0
Nucleotide salvage	R-HSA-8956321	9.907939e-01	0.004	0	0
Urea cycle	R-HSA-70635	9.909808e-01	0.004	0	0
Sphingolipid catabolism	R-HSA-9845614	9.909808e-01	0.004	0	0
Suppression of phagosomal maturation	R-HSA-9637687	9.909808e-01	0.004	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.910812e-01	0.004	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.911544e-01	0.004	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.917439e-01	0.004	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.921574e-01	0.003	0	0
SLC transporter disorders	R-HSA-5619102	9.922138e-01	0.003	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.924725e-01	0.003	0	0
Orc1 removal from chromatin	R-HSA-68949	9.928721e-01	0.003	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.928721e-01	0.003	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.931478e-01	0.003	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.932501e-01	0.003	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.932821e-01	0.003	0	0
Insulin receptor recycling	R-HSA-77387	9.932821e-01	0.003	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.936655e-01	0.003	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.939423e-01	0.003	0	0
Thyroxine biosynthesis	R-HSA-209968	9.942023e-01	0.003	0	0
RSV-host interactions	R-HSA-9833110	9.948540e-01	0.002	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.949965e-01	0.002	0	0
Neurotransmitter clearance	R-HSA-112311	9.949965e-01	0.002	0	0
Paracetamol ADME	R-HSA-9753281	9.950036e-01	0.002	0	0
Immune System	R-HSA-168256	9.951811e-01	0.002	0	0
Nicotinate metabolism	R-HSA-196807	9.952413e-01	0.002	0	0
ABC transporter disorders	R-HSA-5619084	9.952441e-01	0.002	0	0
Integrin cell surface interactions	R-HSA-216083	9.952441e-01	0.002	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.956819e-01	0.002	0	0
Cargo concentration in the ER	R-HSA-5694530	9.956819e-01	0.002	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.956819e-01	0.002	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.957437e-01	0.002	0	0
Signaling by GPCR	R-HSA-372790	9.962154e-01	0.002	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.963172e-01	0.002	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.965993e-01	0.001	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.967840e-01	0.001	0	0
ECM proteoglycans	R-HSA-3000178	9.969622e-01	0.001	0	0
tRNA processing	R-HSA-72306	9.970648e-01	0.001	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.972585e-01	0.001	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.975706e-01	0.001	0	0
Hyaluronan metabolism	R-HSA-2142845	9.976049e-01	0.001	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.978703e-01	0.001	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.979331e-01	0.001	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.979331e-01	0.001	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.980731e-01	0.001	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.981863e-01	0.001	0	0
Glycosphingolipid transport	R-HSA-9845576	9.982163e-01	0.001	0	0
Complex IV assembly	R-HSA-9864848	9.983645e-01	0.001	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.983645e-01	0.001	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.984608e-01	0.001	0	0
Metabolism of folate and pterines	R-HSA-196757	9.984608e-01	0.001	0	0
ER-Phagosome pathway	R-HSA-1236974	9.986940e-01	0.001	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.987023e-01	0.001	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.987850e-01	0.001	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.988062e-01	0.001	0	0
Metabolism of steroid hormones	R-HSA-196071	9.988342e-01	0.001	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.988538e-01	0.000	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.989869e-01	0.000	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.991465e-01	0.000	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.992655e-01	0.000	0	0
Parasite infection	R-HSA-9664407	9.992655e-01	0.000	0	0
Leishmania phagocytosis	R-HSA-9664417	9.992655e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.992897e-01	0.000	0	0
Metabolism of cofactors	R-HSA-8978934	9.992897e-01	0.000	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.993644e-01	0.000	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.993644e-01	0.000	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.994094e-01	0.000	0	0
Leishmania infection	R-HSA-9658195	9.994094e-01	0.000	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.994516e-01	0.000	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.994855e-01	0.000	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.994996e-01	0.000	0	0
Glutathione conjugation	R-HSA-156590	9.995071e-01	0.000	0	0
Metabolism of polyamines	R-HSA-351202	9.995071e-01	0.000	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.995116e-01	0.000	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.995268e-01	0.000	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.995268e-01	0.000	0	0
Neddylation	R-HSA-8951664	9.995681e-01	0.000	0	0
Pyruvate metabolism	R-HSA-70268	9.995777e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.995826e-01	0.000	0	0
Complex I biogenesis	R-HSA-6799198	9.996707e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.996717e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.997046e-01	0.000	0	0
Formation of the cornified envelope	R-HSA-6809371	9.998012e-01	0.000	0	0
Azathioprine ADME	R-HSA-9748787	9.998047e-01	0.000	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.998047e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.998153e-01	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.998325e-01	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.998380e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.998566e-01	0.000	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.998723e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.998875e-01	0.000	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.998885e-01	0.000	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.999027e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999151e-01	0.000	0	0
Digestion	R-HSA-8935690	9.999194e-01	0.000	0	0
Dectin-2 family	R-HSA-5621480	9.999305e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.999327e-01	0.000	0	0
Iron uptake and transport	R-HSA-917937	9.999354e-01	0.000	0	0
Sialic acid metabolism	R-HSA-4085001	9.999482e-01	0.000	0	0
tRNA Aminoacylation	R-HSA-379724	9.999553e-01	0.000	0	0
Interleukin-10 signaling	R-HSA-6783783	9.999571e-01	0.000	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999610e-01	0.000	0	0
Endogenous sterols	R-HSA-211976	9.999615e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999626e-01	0.000	0	0
Translation	R-HSA-72766	9.999699e-01	0.000	0	0
Digestion and absorption	R-HSA-8963743	9.999713e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.999735e-01	0.000	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.999753e-01	0.000	0	0
Xenobiotics	R-HSA-211981	9.999753e-01	0.000	0	0
Glycosphingolipid biosynthesis	R-HSA-9840309	9.999753e-01	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.999787e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999801e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.999841e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.999847e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999847e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999855e-01	0.000	0	0
Glycosphingolipid catabolism	R-HSA-9840310	9.999898e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999905e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999920e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.999924e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999926e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999931e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.999931e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.999935e-01	0.000	0	0
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.999944e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999968e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999974e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999978e-01	0.000	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.999979e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999980e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999987e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999988e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999989e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999989e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999993e-01	0.000	0	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999994e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999995e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999997e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999997e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999998e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999999e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999999e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	1.000000e+00	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000	0	0
Disease	R-HSA-1643685	1.000000e+00	0.000	0	0
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000	0	0
Initial triggering of complement	R-HSA-166663	1.000000e+00	0.000	0	0
Keratinization	R-HSA-6805567	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000e+00	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000	0	0
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000	0	0
Post-translational protein modification	R-HSA-597592	1.000000e+00	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cellular response to heat stress	R-HSA-3371556	2.817435e-11	10.550	0	0
Attenuation phase	R-HSA-3371568	4.441453e-10	9.352	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	7.485527e-10	9.126	0	0
HSF1-dependent transactivation	R-HSA-3371571	1.781156e-09	8.749	0	0
Signal Transduction	R-HSA-162582	1.192574e-08	7.924	1	0
Mitotic Prometaphase	R-HSA-68877	1.634952e-07	6.786	0	0
HSF1 activation	R-HSA-3371511	2.490077e-07	6.604	0	0
Cell Cycle, Mitotic	R-HSA-69278	3.132155e-07	6.504	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.651403e-07	6.438	0	0
Cell Cycle	R-HSA-1640170	8.093757e-07	6.092	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	8.853960e-07	6.053	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.489671e-06	5.827	0	0
M Phase	R-HSA-68886	1.693033e-06	5.771	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	3.382823e-06	5.471	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	3.667842e-06	5.436	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.746056e-06	5.426	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.070250e-05	4.971	0	0
Amplification of signal from the kinetochores	R-HSA-141424	1.070250e-05	4.971	0	0
Separation of Sister Chromatids	R-HSA-2467813	1.346733e-05	4.871	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.460509e-05	4.835	0	0
Mitotic Anaphase	R-HSA-68882	1.429674e-05	4.845	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.587375e-05	4.799	0	0
G2/M Transition	R-HSA-69275	1.941299e-05	4.712	0	0
Apoptotic execution phase	R-HSA-75153	2.281923e-05	4.642	0	0
Mitotic G2-G2/M phases	R-HSA-453274	2.421975e-05	4.616	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.616581e-05	4.582	0	0
Membrane Trafficking	R-HSA-199991	2.732565e-05	4.563	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.904284e-05	4.537	0	0
Cellular responses to stress	R-HSA-2262752	3.813811e-05	4.419	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.823836e-05	4.317	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.977520e-05	4.303	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	6.370795e-05	4.196	0	0
NRAGE signals death through JNK	R-HSA-193648	6.333516e-05	4.198	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	8.324167e-05	4.080	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.057457e-04	3.976	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.058866e-04	3.975	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.098873e-04	3.959	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.339654e-04	3.873	0	0
Kinesins	R-HSA-983189	1.367076e-04	3.864	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	1.683018e-04	3.774	0	0
Cellular responses to stimuli	R-HSA-8953897	1.692058e-04	3.772	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.837850e-04	3.736	0	0
Cell-extracellular matrix interactions	R-HSA-446353	2.103649e-04	3.677	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	2.247992e-04	3.648	0	0
Recycling pathway of L1	R-HSA-437239	2.883737e-04	3.540	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.025051e-04	3.519	1	1
Selective autophagy	R-HSA-9663891	3.053478e-04	3.515	0	0
Autophagy	R-HSA-9612973	4.774423e-04	3.321	1	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	4.988157e-04	3.302	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	5.274977e-04	3.278	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	5.880701e-04	3.231	0	0
ISG15 antiviral mechanism	R-HSA-1169408	5.995406e-04	3.222	0	0
Cell Cycle Checkpoints	R-HSA-69620	6.016771e-04	3.221	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	6.316030e-04	3.200	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	6.316030e-04	3.200	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	6.316030e-04	3.200	0	0
Polo-like kinase mediated events	R-HSA-156711	8.165557e-04	3.088	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	9.185720e-04	3.037	0	0
G alpha (12/13) signalling events	R-HSA-416482	9.162857e-04	3.038	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	9.870292e-04	3.006	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	1.130740e-03	2.947	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.100240e-03	2.959	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.100240e-03	2.959	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.199531e-03	2.921	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.219252e-03	2.914	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.322282e-03	2.879	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.419821e-03	2.848	0	0
Centrosome maturation	R-HSA-380287	1.446436e-03	2.840	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.626577e-03	2.789	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.626577e-03	2.789	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.626577e-03	2.789	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.626577e-03	2.789	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.626577e-03	2.789	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.626577e-03	2.789	0	0
Aggrephagy	R-HSA-9646399	1.593664e-03	2.798	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	1.583971e-03	2.800	0	0
Death Receptor Signaling	R-HSA-73887	1.487855e-03	2.827	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.626577e-03	2.789	0	0
Chromatin organization	R-HSA-4839726	1.601214e-03	2.796	0	0
Macroautophagy	R-HSA-1632852	1.521428e-03	2.818	1	1
Chromatin modifying enzymes	R-HSA-3247509	1.614651e-03	2.792	0	0
Nuclear import of Rev protein	R-HSA-180746	1.494978e-03	2.825	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.942797e-03	2.712	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.048196e-03	2.689	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.086239e-03	2.681	0	0
Oncogenic MAPK signaling	R-HSA-6802957	2.252132e-03	2.647	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.408566e-03	2.618	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.543455e-03	2.595	0	0
Signaling by Hippo	R-HSA-2028269	2.445316e-03	2.612	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.589762e-03	2.587	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.645136e-03	2.578	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.645136e-03	2.578	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	2.651507e-03	2.577	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	2.850870e-03	2.545	0	0
Gap junction trafficking and regulation	R-HSA-157858	3.132226e-03	2.504	0	0
Signaling by APC mutants	R-HSA-4839744	3.794725e-03	2.421	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	3.794725e-03	2.421	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	3.794725e-03	2.421	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	3.794725e-03	2.421	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	3.827445e-03	2.417	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.751098e-03	2.426	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.803987e-03	2.420	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.803987e-03	2.420	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	3.749734e-03	2.426	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	4.161684e-03	2.381	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	4.244668e-03	2.372	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.358552e-03	2.361	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	4.362970e-03	2.360	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	4.429163e-03	2.354	0	0
Metabolism of non-coding RNA	R-HSA-194441	5.262011e-03	2.279	0	0
snRNP Assembly	R-HSA-191859	5.262011e-03	2.279	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	4.920282e-03	2.308	0	0
PKMTs methylate histone lysines	R-HSA-3214841	5.201936e-03	2.284	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	5.201936e-03	2.284	0	0
Interleukin-37 signaling	R-HSA-9008059	5.097286e-03	2.293	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.267767e-03	2.278	0	0
Signaling by AXIN mutants	R-HSA-4839735	5.267767e-03	2.278	0	0
Signaling by AMER1 mutants	R-HSA-4839748	5.267767e-03	2.278	0	0
IRE1alpha activates chaperones	R-HSA-381070	5.497287e-03	2.260	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	5.516548e-03	2.258	0	0
AURKA Activation by TPX2	R-HSA-8854518	5.571011e-03	2.254	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.571011e-03	2.254	0	0
PKR-mediated signaling	R-HSA-9833482	5.953819e-03	2.225	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	6.506723e-03	2.187	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	6.506723e-03	2.187	0	0
Signaling by RAF1 mutants	R-HSA-9656223	6.078359e-03	2.216	0	0
MAP2K and MAPK activation	R-HSA-5674135	6.078359e-03	2.216	0	0
PIP3 activates AKT signaling	R-HSA-1257604	6.520926e-03	2.186	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.023957e-03	2.153	0	0
MTOR signalling	R-HSA-165159	7.067692e-03	2.151	1	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.679139e-03	2.115	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	7.860117e-03	2.105	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	8.734072e-03	2.059	0	0
Lipophagy	R-HSA-9613354	8.935070e-03	2.049	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	8.935070e-03	2.049	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	8.936687e-03	2.049	0	0
mTORC1-mediated signalling	R-HSA-166208	9.889020e-03	2.005	0	0
Intracellular signaling by second messengers	R-HSA-9006925	9.242894e-03	2.034	0	0
Gap junction trafficking	R-HSA-190828	9.423479e-03	2.026	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	9.894901e-03	2.005	0	0
MHC class II antigen presentation	R-HSA-2132295	1.065538e-02	1.972	0	0
L1CAM interactions	R-HSA-373760	1.099369e-02	1.959	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.108415e-02	1.955	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	1.118254e-02	1.951	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	1.118254e-02	1.951	0	0
RAF activation	R-HSA-5673000	1.191958e-02	1.924	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	1.216897e-02	1.915	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.234812e-02	1.908	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	1.234812e-02	1.908	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.234812e-02	1.908	0	0
Signaling by RAS mutants	R-HSA-6802949	1.234812e-02	1.908	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	1.338135e-02	1.874	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.386419e-02	1.858	0	0
Neurodegenerative Diseases	R-HSA-8863678	1.440012e-02	1.842	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.440012e-02	1.842	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	1.509056e-02	1.821	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.511638e-02	1.821	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	1.514087e-02	1.820	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	1.514087e-02	1.820	0	0
Apoptosis	R-HSA-109581	1.541198e-02	1.812	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.643827e-02	1.784	0	0
tRNA processing in the nucleus	R-HSA-6784531	1.670353e-02	1.777	0	0
PI Metabolism	R-HSA-1483255	1.675630e-02	1.776	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.685463e-02	1.773	0	0
Vesicle-mediated transport	R-HSA-5653656	1.753869e-02	1.756	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.845232e-02	1.734	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.024796e-02	1.694	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.034326e-02	1.692	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.213098e-02	1.655	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	2.534304e-02	1.596	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.257163e-02	1.646	0	0
mRNA 3'-end processing	R-HSA-72187	2.534416e-02	1.596	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.534304e-02	1.596	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.534304e-02	1.596	0	0
HATs acetylate histones	R-HSA-3214847	2.399294e-02	1.620	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.372973e-02	1.625	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.257163e-02	1.646	0	0
Striated Muscle Contraction	R-HSA-390522	2.594919e-02	1.586	0	0
Mitotic Prophase	R-HSA-68875	2.639226e-02	1.579	0	0
Notch-HLH transcription pathway	R-HSA-350054	2.876723e-02	1.541	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	2.880941e-02	1.540	0	0
Formation of annular gap junctions	R-HSA-196025	2.880941e-02	1.540	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	2.893492e-02	1.539	0	0
FLT3 Signaling	R-HSA-9607240	3.082197e-02	1.511	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	3.103331e-02	1.508	0	0
Muscle contraction	R-HSA-397014	3.130562e-02	1.504	0	0
Heme signaling	R-HSA-9707616	3.416739e-02	1.466	0	0
MAPK family signaling cascades	R-HSA-5683057	3.446901e-02	1.463	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.465660e-02	1.460	0	0
Co-stimulation by CD28	R-HSA-389356	3.491222e-02	1.457	0	0
Breakdown of the nuclear lamina	R-HSA-352238	3.942532e-02	1.404	0	0
IRS activation	R-HSA-74713	3.733949e-02	1.428	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.733949e-02	1.428	0	0
Gap junction degradation	R-HSA-190873	3.769647e-02	1.424	0	0
RUNX2 regulates bone development	R-HSA-8941326	3.819448e-02	1.418	0	0
GP1b-IX-V activation signalling	R-HSA-430116	3.769647e-02	1.424	0	0
Rab regulation of trafficking	R-HSA-9007101	3.646348e-02	1.438	0	0
Axon guidance	R-HSA-422475	3.667903e-02	1.436	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.769647e-02	1.424	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.698262e-02	1.432	0	0
Regulation of TP53 Activity	R-HSA-5633007	3.573459e-02	1.447	1	0
Unfolded Protein Response (UPR)	R-HSA-381119	3.991243e-02	1.399	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	4.133586e-02	1.384	0	0
Regulation of KIT signaling	R-HSA-1433559	4.133586e-02	1.384	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	4.503478e-02	1.346	0	0
HDMs demethylate histones	R-HSA-3214842	4.536735e-02	1.343	0	0
Glycolysis	R-HSA-70171	4.552072e-02	1.342	0	0
Post NMDA receptor activation events	R-HSA-438064	4.671531e-02	1.331	1	0
MET activates RAP1 and RAC1	R-HSA-8875555	4.798567e-02	1.319	0	0
Folding of actin by CCT/TriC	R-HSA-390450	4.798567e-02	1.319	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.836442e-02	1.315	0	0
Programmed Cell Death	R-HSA-5357801	4.960706e-02	1.304	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	4.992056e-02	1.302	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	4.992056e-02	1.302	0	0
DCC mediated attractive signaling	R-HSA-418885	4.992056e-02	1.302	0	0
Cilium Assembly	R-HSA-5617833	5.077550e-02	1.294	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	5.173777e-02	1.286	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.173777e-02	1.286	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	5.173777e-02	1.286	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	5.173777e-02	1.286	0	0
Interferon Signaling	R-HSA-913531	5.251801e-02	1.280	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	5.361246e-02	1.271	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	5.387866e-02	1.269	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	6.555188e-02	1.183	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	6.555188e-02	1.183	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	6.555188e-02	1.183	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	6.555188e-02	1.183	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	6.555188e-02	1.183	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	6.555188e-02	1.183	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	6.555188e-02	1.183	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	6.555188e-02	1.183	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	6.555188e-02	1.183	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	6.555188e-02	1.183	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	6.555188e-02	1.183	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.967131e-02	1.224	0	0
Phosphorylation of the APC/C	R-HSA-176412	5.947481e-02	1.226	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.927427e-02	1.227	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	6.264104e-02	1.203	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	6.495798e-02	1.187	0	0
Nervous system development	R-HSA-9675108	6.456171e-02	1.190	0	0
Smooth Muscle Contraction	R-HSA-445355	5.724029e-02	1.242	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	6.296677e-02	1.201	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	6.495798e-02	1.187	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	6.029761e-02	1.220	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	5.970572e-02	1.224	1	0
ChREBP activates metabolic gene expression	R-HSA-163765	5.967131e-02	1.224	0	0
Gap junction assembly	R-HSA-190861	6.732366e-02	1.172	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.841102e-02	1.165	0	0
RAF/MAP kinase cascade	R-HSA-5673001	6.986778e-02	1.156	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.999677e-02	1.155	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.999677e-02	1.155	0	0
Activation of RAC1	R-HSA-428540	7.272587e-02	1.138	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	7.272587e-02	1.138	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	7.297591e-02	1.137	0	0
Signaling by EGFR	R-HSA-177929	7.437845e-02	1.129	0	0
Late endosomal microautophagy	R-HSA-9615710	7.553882e-02	1.122	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	7.769039e-02	1.110	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	8.718855e-02	1.060	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	8.718855e-02	1.060	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	8.718855e-02	1.060	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	8.718855e-02	1.060	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	8.718855e-02	1.060	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	8.718855e-02	1.060	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.710278e-02	1.060	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	8.710278e-02	1.060	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	8.147456e-02	1.089	0	0
EGFR downregulation	R-HSA-182971	9.416958e-02	1.026	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.743455e-02	1.058	0	0
Chaperonin-mediated protein folding	R-HSA-390466	8.056426e-02	1.094	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	8.710278e-02	1.060	0	0
Regulation of CDH1 Function	R-HSA-9764561	8.074203e-02	1.093	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	9.388705e-02	1.027	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.456012e-02	1.073	1	1
Interleukin-15 signaling	R-HSA-8983432	8.710278e-02	1.060	0	0
TBC/RABGAPs	R-HSA-8854214	8.827696e-02	1.054	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	8.966312e-02	1.047	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	8.600349e-02	1.065	1	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	8.510933e-02	1.070	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	8.074203e-02	1.093	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	9.388705e-02	1.027	0	0
Platelet sensitization by LDL	R-HSA-432142	9.388705e-02	1.027	0	0
Regulation of TP53 Degradation	R-HSA-6804757	8.300822e-02	1.081	0	0
MET interacts with TNS proteins	R-HSA-8875513	9.585367e-02	1.018	0	0
HCMV Early Events	R-HSA-9609690	9.656915e-02	1.015	0	0
Deubiquitination	R-HSA-5688426	9.685490e-02	1.014	0	0
COPI-mediated anterograde transport	R-HSA-6807878	9.713468e-02	1.013	0	0
Drug resistance of PDGFR mutants	R-HSA-9674415	9.851385e-02	1.007	0	0
PDGFR mutants bind TKIs	R-HSA-9674428	9.851385e-02	1.007	0	0
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	9.851385e-02	1.007	0	0
Imatinib-resistant PDGFR mutants	R-HSA-9674396	9.851385e-02	1.007	0	0
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	9.851385e-02	1.007	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.851385e-02	1.007	0	0
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	9.851385e-02	1.007	0	0
Cellular Senescence	R-HSA-2559583	1.005186e-01	0.998	0	0
Inositol phosphate metabolism	R-HSA-1483249	1.011482e-01	0.995	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.027392e-01	0.988	0	0
Regulation of gap junction activity	R-HSA-191650	1.292555e-01	0.889	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.292555e-01	0.889	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.292555e-01	0.889	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.292555e-01	0.889	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.292555e-01	0.889	0	0
Type I hemidesmosome assembly	R-HSA-446107	1.078702e-01	0.967	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	1.078702e-01	0.967	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.078702e-01	0.967	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	1.302379e-01	0.885	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	1.302379e-01	0.885	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.072046e-01	0.970	0	0
Co-inhibition by CTLA4	R-HSA-389513	1.213899e-01	0.916	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.213899e-01	0.916	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.213899e-01	0.916	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.213899e-01	0.916	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.213899e-01	0.916	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.213899e-01	0.916	0	0
Translation initiation complex formation	R-HSA-72649	1.162644e-01	0.935	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.182380e-01	0.927	0	0
Integrin signaling	R-HSA-354192	1.151188e-01	0.939	0	0
Protein folding	R-HSA-391251	1.163654e-01	0.934	0	0
G0 and Early G1	R-HSA-1538133	1.043595e-01	0.981	0	0
Rap1 signalling	R-HSA-392517	1.072046e-01	0.970	0	0
Myogenesis	R-HSA-525793	1.191724e-01	0.924	0	0
Resolution of D-Loop Structures	R-HSA-5693537	1.264335e-01	0.898	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.195587e-01	0.922	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.151188e-01	0.939	0	0
Interleukin-2 family signaling	R-HSA-451927	1.202637e-01	0.920	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.195587e-01	0.922	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	1.069191e-01	0.971	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	1.069191e-01	0.971	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.043595e-01	0.981	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	1.191724e-01	0.924	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.292555e-01	0.889	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.174900e-01	0.930	0	0
Interleukin-9 signaling	R-HSA-8985947	1.078702e-01	0.967	0	0
Adrenoceptors	R-HSA-390696	1.078702e-01	0.967	0	0
Calcineurin activates NFAT	R-HSA-2025928	1.302379e-01	0.885	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.157439e-01	0.937	0	0
Nuclear RNA decay	R-HSA-9930044	1.151188e-01	0.939	0	0
Signaling by WNT in cancer	R-HSA-4791275	1.043595e-01	0.981	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.302379e-01	0.885	0	0
Physiological factors	R-HSA-5578768	1.195587e-01	0.922	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.049960e-01	0.979	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.145380e-01	0.941	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.179416e-01	0.928	0	0
The NLRP3 inflammasome	R-HSA-844456	1.072046e-01	0.970	0	0
Interleukin-1 processing	R-HSA-448706	1.302379e-01	0.885	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.102271e-01	0.958	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	1.307667e-01	0.884	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	1.320891e-01	0.879	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	1.339740e-01	0.873	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	1.342788e-01	0.872	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.342788e-01	0.872	0	0
Host Interactions of HIV factors	R-HSA-162909	1.344408e-01	0.871	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.361811e-01	0.866	0	0
p75NTR signals via NF-kB	R-HSA-193639	1.374743e-01	0.862	0	0
Diseases of programmed cell death	R-HSA-9645723	1.392611e-01	0.856	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.433712e-01	0.844	0	0
Glucose metabolism	R-HSA-70326	1.437036e-01	0.843	0	0
Circadian clock	R-HSA-9909396	1.440899e-01	0.841	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.449428e-01	0.839	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	1.456404e-01	0.837	0	0
Signaling by VEGF	R-HSA-194138	1.472804e-01	0.832	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.495186e-01	0.825	0	0
Signaling by NTRKs	R-HSA-166520	1.497441e-01	0.825	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.531201e-01	0.815	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.536816e-01	0.813	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.540646e-01	0.812	0	0
Signal attenuation	R-HSA-74749	1.540646e-01	0.812	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	1.540646e-01	0.812	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	1.540646e-01	0.812	0	0
Signaling by Leptin	R-HSA-2586552	1.540646e-01	0.812	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.873280e-01	0.727	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.873280e-01	0.727	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.873280e-01	0.727	0	0
TWIK-related spinal cord K+ channel (TRESK)	R-HSA-1299344	1.873280e-01	0.727	0	0
TICAM1 deficiency - HSE	R-HSA-5602566	1.873280e-01	0.727	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.873280e-01	0.727	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.873280e-01	0.727	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.873280e-01	0.727	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	1.648534e-01	0.783	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.648534e-01	0.783	0	0
Reelin signalling pathway	R-HSA-8866376	1.648534e-01	0.783	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.648534e-01	0.783	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.018911e-01	0.695	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.791215e-01	0.747	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.563905e-01	0.806	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.563905e-01	0.806	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.563905e-01	0.806	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.051836e-01	0.688	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.051836e-01	0.688	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.968157e-01	0.706	0	0
Interleukin receptor SHC signaling	R-HSA-912526	1.858502e-01	0.731	0	0
Deadenylation of mRNA	R-HSA-429947	2.036147e-01	0.691	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	2.036147e-01	0.691	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.720708e-01	0.764	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	1.711143e-01	0.767	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.897758e-01	0.722	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	1.968157e-01	0.706	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.032480e-01	0.692	0	0
Interleukin-2 signaling	R-HSA-9020558	1.791215e-01	0.747	0	0
RET signaling	R-HSA-8853659	1.635249e-01	0.786	0	0
MET promotes cell motility	R-HSA-8875878	1.906476e-01	0.720	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.762060e-01	0.754	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	1.745158e-01	0.758	0	0
NF-kB is activated and signals survival	R-HSA-209560	2.051836e-01	0.688	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.744020e-01	0.758	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.744020e-01	0.758	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.744020e-01	0.758	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.744020e-01	0.758	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.018911e-01	0.695	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.745158e-01	0.758	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.036147e-01	0.691	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.846322e-01	0.734	0	0
Semaphorin interactions	R-HSA-373755	2.077570e-01	0.682	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	1.897666e-01	0.722	0	0
Signaling by SCF-KIT	R-HSA-1433557	1.649398e-01	0.783	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.744020e-01	0.758	0	0
Ub-specific processing proteases	R-HSA-5689880	2.054235e-01	0.687	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	1.563905e-01	0.806	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.762060e-01	0.754	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.858502e-01	0.731	0	0
PECAM1 interactions	R-HSA-210990	1.791215e-01	0.747	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	2.032480e-01	0.692	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.762060e-01	0.754	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.745158e-01	0.758	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.563905e-01	0.806	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.762060e-01	0.754	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	1.699575e-01	0.770	0	0
Carnitine shuttle	R-HSA-200425	1.858502e-01	0.731	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	2.018911e-01	0.695	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	1.906476e-01	0.720	0	0
G1/S-Specific Transcription	R-HSA-69205	1.635249e-01	0.786	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.018911e-01	0.695	0	0
Growth hormone receptor signaling	R-HSA-982772	1.858502e-01	0.731	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	2.673969e-01	0.573	0	0
NFG and proNGF binds to p75NTR	R-HSA-205017	2.673969e-01	0.573	0	0
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.673969e-01	0.573	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	2.673969e-01	0.573	0	0
Defective SLC12A3 causes Gitelman syndrome (GS)	R-HSA-5619087	2.673969e-01	0.573	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.673969e-01	0.573	0	0
TRAF3 deficiency - HSE	R-HSA-5602571	2.673969e-01	0.573	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	2.673969e-01	0.573	0	0
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.673969e-01	0.573	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	3.395812e-01	0.469	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.395812e-01	0.469	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.395812e-01	0.469	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	3.395812e-01	0.469	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.397399e-01	0.620	0	0
Regulation of PTEN localization	R-HSA-8948747	2.778810e-01	0.556	0	0
PTK6 Expression	R-HSA-8849473	2.778810e-01	0.556	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	2.778810e-01	0.556	0	0
SOS-mediated signalling	R-HSA-112412	2.778810e-01	0.556	0	0
Recycling of eIF2:GDP	R-HSA-72731	2.778810e-01	0.556	0	0
Defective MMACHC causes MAHCC	R-HSA-3359474	4.046569e-01	0.393	0	0
Axonal growth stimulation	R-HSA-209563	4.046569e-01	0.393	0	0
MET activates PTPN11	R-HSA-8865999	4.046569e-01	0.393	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.046569e-01	0.393	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.046569e-01	0.393	0	0
Defective HPRT1 disrupts guanine and hypoxanthine salvage	R-HSA-9734281	4.046569e-01	0.393	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.320338e-01	0.634	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.320338e-01	0.634	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.320338e-01	0.634	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	3.158896e-01	0.500	0	0
MET receptor recycling	R-HSA-8875656	3.158896e-01	0.500	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	3.158896e-01	0.500	0	0
Formation of axial mesoderm	R-HSA-9796292	2.594660e-01	0.586	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.594660e-01	0.586	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.181124e-01	0.661	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.181124e-01	0.661	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.399889e-01	0.620	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.534220e-01	0.452	0	0
ARMS-mediated activation	R-HSA-170984	3.534220e-01	0.452	0	0
Interleukin-21 signaling	R-HSA-9020958	3.534220e-01	0.452	0	0
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	3.534220e-01	0.452	0	0
ALK mutants bind TKIs	R-HSA-9700645	3.534220e-01	0.452	0	0
NADE modulates death signalling	R-HSA-205025	4.633238e-01	0.334	0	0
HCN channels	R-HSA-1296061	4.633238e-01	0.334	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.633238e-01	0.334	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.633238e-01	0.334	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.633238e-01	0.334	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.633238e-01	0.334	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	4.633238e-01	0.334	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	2.219158e-01	0.654	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	3.153185e-01	0.501	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	2.406887e-01	0.619	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.850584e-01	0.545	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.850584e-01	0.545	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.902031e-01	0.409	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	2.552337e-01	0.593	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.312093e-01	0.480	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	3.713736e-01	0.430	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	4.260168e-01	0.371	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.162125e-01	0.287	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.162125e-01	0.287	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	5.162125e-01	0.287	0	0
Defective F9 activation	R-HSA-9673221	5.162125e-01	0.287	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.162125e-01	0.287	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.162125e-01	0.287	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.652012e-01	0.576	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	3.191923e-01	0.496	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	3.191923e-01	0.496	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	3.991172e-01	0.399	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.776927e-01	0.423	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.606967e-01	0.337	0	0
GAB1 signalosome	R-HSA-180292	4.265102e-01	0.370	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.296671e-01	0.482	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	3.461752e-01	0.461	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.001449e-01	0.398	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	4.238451e-01	0.373	0	0
Regulation of signaling by CBL	R-HSA-912631	4.534500e-01	0.343	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	4.534500e-01	0.343	0	0
p75NTR recruits signalling complexes	R-HSA-209543	4.941185e-01	0.306	0	0
Polymerase switching	R-HSA-69091	4.941185e-01	0.306	0	0
Leading Strand Synthesis	R-HSA-69109	4.941185e-01	0.306	0	0
VLDLR internalisation and degradation	R-HSA-8866427	4.941185e-01	0.306	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.638919e-01	0.249	0	0
PKB-mediated events	R-HSA-109703	5.638919e-01	0.249	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.638919e-01	0.249	0	0
Cam-PDE 1 activation	R-HSA-111957	5.638919e-01	0.249	0	0
PDE3B signalling	R-HSA-165160	5.638919e-01	0.249	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	5.638919e-01	0.249	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.638919e-01	0.249	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.638919e-01	0.249	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.638919e-01	0.249	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	5.638919e-01	0.249	0	0
Signaling by MAPK mutants	R-HSA-9652817	5.638919e-01	0.249	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.638919e-01	0.249	0	0
Signaling by NOTCH2	R-HSA-1980145	4.203322e-01	0.376	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	4.203322e-01	0.376	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.466156e-01	0.350	0	0
Regulation of RAS by GAPs	R-HSA-5658442	3.961153e-01	0.402	0	0
mRNA Splicing	R-HSA-72172	2.415205e-01	0.617	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	3.098442e-01	0.509	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	5.261936e-01	0.279	0	0
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	5.261936e-01	0.279	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.261936e-01	0.279	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	3.659454e-01	0.437	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	4.018701e-01	0.396	0	0
Cap-dependent Translation Initiation	R-HSA-72737	3.746135e-01	0.426	0	0
Amino acids regulate mTORC1	R-HSA-9639288	4.460327e-01	0.351	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.460327e-01	0.351	0	0
Signaling by Erythropoietin	R-HSA-9006335	4.912356e-01	0.309	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.912356e-01	0.309	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	4.912356e-01	0.309	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	4.883438e-01	0.311	0	0
Prolactin receptor signaling	R-HSA-1170546	5.568627e-01	0.254	0	0
CRMPs in Sema3A signaling	R-HSA-399956	5.568627e-01	0.254	0	0
Retrograde neurotrophin signalling	R-HSA-177504	5.568627e-01	0.254	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.568627e-01	0.254	0	0
Signaling by LTK in cancer	R-HSA-9842640	6.068749e-01	0.217	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.068749e-01	0.217	0	0
Erythropoietin activates STAT5	R-HSA-9027283	6.068749e-01	0.217	0	0
STAT5 Activation	R-HSA-9645135	6.068749e-01	0.217	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.068749e-01	0.217	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.762859e-01	0.322	0	0
Erythropoietin activates RAS	R-HSA-9027284	5.860914e-01	0.232	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.860914e-01	0.232	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	5.860914e-01	0.232	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.860914e-01	0.232	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.860914e-01	0.232	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.860914e-01	0.232	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	5.217617e-01	0.283	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	5.217617e-01	0.283	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	5.786942e-01	0.238	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	5.583523e-01	0.253	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	6.014844e-01	0.221	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.138658e-01	0.212	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	6.138658e-01	0.212	0	0
Meiotic synapsis	R-HSA-1221632	6.055691e-01	0.218	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	6.055691e-01	0.218	0	0
PTEN Regulation	R-HSA-6807070	2.718617e-01	0.566	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	5.056292e-01	0.296	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	5.056292e-01	0.296	0	0
Eukaryotic Translation Initiation	R-HSA-72613	3.746135e-01	0.426	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.991172e-01	0.399	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.991172e-01	0.399	0	0
FOXO-mediated transcription	R-HSA-9614085	5.883491e-01	0.230	0	0
Signaling by PDGFR in disease	R-HSA-9671555	3.080473e-01	0.511	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.261936e-01	0.279	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.237679e-01	0.281	0	0
Signaling by ERBB2	R-HSA-1227986	4.090652e-01	0.388	0	0
p75NTR regulates axonogenesis	R-HSA-193697	3.534220e-01	0.452	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	3.433966e-01	0.464	0	0
Developmental Cell Lineages	R-HSA-9734767	3.352084e-01	0.475	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	4.516820e-01	0.345	0	0
Interleukin-20 family signaling	R-HSA-8854691	5.786942e-01	0.238	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	3.158896e-01	0.500	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.181124e-01	0.661	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.860914e-01	0.232	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.014844e-01	0.221	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.199283e-01	0.377	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	5.165182e-01	0.287	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	2.778810e-01	0.556	0	0
Regulation of CDH11 function	R-HSA-9762292	3.902031e-01	0.409	0	0
PI3K/AKT activation	R-HSA-198203	3.902031e-01	0.409	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.260168e-01	0.371	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	3.390687e-01	0.470	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	5.550988e-01	0.256	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	5.952207e-01	0.225	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.552337e-01	0.593	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.058722e-01	0.296	0	0
Eukaryotic Translation Elongation	R-HSA-156842	4.891293e-01	0.311	0	0
Formation of definitive endoderm	R-HSA-9823730	4.798482e-01	0.319	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.397399e-01	0.620	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	2.320338e-01	0.634	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	3.534220e-01	0.452	0	0
TGFBR3 expression	R-HSA-9839394	4.008481e-01	0.397	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	5.638919e-01	0.249	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	4.602936e-01	0.337	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.185672e-01	0.285	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	5.735985e-01	0.241	0	0
Prolonged ERK activation events	R-HSA-169893	3.433966e-01	0.464	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.406887e-01	0.619	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.080473e-01	0.511	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.460327e-01	0.351	0	0
Epigenetic regulation of gene expression	R-HSA-212165	3.027123e-01	0.519	0	0
Cellular response to starvation	R-HSA-9711097	5.554425e-01	0.255	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	5.952207e-01	0.225	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.159135e-01	0.287	0	0
Regulation of endogenous retroelements	R-HSA-9842860	6.232951e-01	0.205	0	0
IGF1R signaling cascade	R-HSA-2428924	6.177618e-01	0.209	0	0
Interleukin-6 signaling	R-HSA-1059683	5.261936e-01	0.279	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	4.488807e-01	0.348	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	5.422608e-01	0.266	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	5.422608e-01	0.266	0	0
VLDL clearance	R-HSA-8964046	2.778810e-01	0.556	0	0
Formation of the posterior neural plate	R-HSA-9832991	4.260168e-01	0.371	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.162125e-01	0.287	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	4.606967e-01	0.337	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	4.203322e-01	0.376	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	4.203322e-01	0.376	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	3.659454e-01	0.437	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.754366e-01	0.240	0	0
S Phase	R-HSA-69242	2.806481e-01	0.552	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	4.199283e-01	0.377	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	2.720230e-01	0.565	0	0
Oncogene Induced Senescence	R-HSA-2559585	4.403970e-01	0.356	0	0
Ca2+ pathway	R-HSA-4086398	6.018525e-01	0.221	0	0
Platelet calcium homeostasis	R-HSA-418360	2.991838e-01	0.524	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.941185e-01	0.306	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.860914e-01	0.232	0	0
Frs2-mediated activation	R-HSA-170968	5.261936e-01	0.279	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	3.886439e-01	0.410	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.323231e-01	0.478	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.886439e-01	0.410	0	0
FasL/ CD95L signaling	R-HSA-75157	4.046569e-01	0.393	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	3.158896e-01	0.500	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	3.534220e-01	0.452	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	3.991172e-01	0.399	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.638919e-01	0.249	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	5.568627e-01	0.254	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	5.550988e-01	0.256	0	0
Hedgehog 'off' state	R-HSA-5610787	2.675963e-01	0.573	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	2.132103e-01	0.671	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	4.994161e-01	0.302	0	0
RNA Polymerase II Transcription	R-HSA-73857	6.012869e-01	0.221	1	0
Gene expression (Transcription)	R-HSA-74160	3.487061e-01	0.458	1	0
HCMV Infection	R-HSA-9609646	2.469711e-01	0.607	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.488807e-01	0.348	0	0
Co-inhibition by PD-1	R-HSA-389948	2.704473e-01	0.568	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.216935e-01	0.654	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.343778e-01	0.630	0	0
Regulation of necroptotic cell death	R-HSA-5675482	3.798838e-01	0.420	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	4.798482e-01	0.319	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	4.203322e-01	0.376	0	0
Signaling by ROBO receptors	R-HSA-376176	3.667078e-01	0.436	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	3.087946e-01	0.510	0	0
Spry regulation of FGF signaling	R-HSA-1295596	3.153185e-01	0.501	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	3.991172e-01	0.399	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	3.191517e-01	0.496	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.912356e-01	0.309	0	0
Signaling by WNT	R-HSA-195721	5.223716e-01	0.282	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.724974e-01	0.565	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	3.983869e-01	0.400	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	4.323124e-01	0.364	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	2.206869e-01	0.656	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.673969e-01	0.573	0	0
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.673969e-01	0.573	0	0
Signalling to ERK5	R-HSA-198765	3.395812e-01	0.469	0	0
CREB phosphorylation	R-HSA-199920	2.397399e-01	0.620	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	4.046569e-01	0.393	0	0
Regulation of IFNG signaling	R-HSA-877312	2.320338e-01	0.634	0	0
WNT mediated activation of DVL	R-HSA-201688	3.534220e-01	0.452	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.633238e-01	0.334	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	3.433966e-01	0.464	0	0
Differentiation of T cells	R-HSA-9945266	3.433966e-01	0.464	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.162125e-01	0.287	0	0
TNF signaling	R-HSA-75893	2.246557e-01	0.648	0	0
Sodium/Calcium exchangers	R-HSA-425561	4.606967e-01	0.337	0	0
Intraflagellar transport	R-HSA-5620924	3.627739e-01	0.440	0	0
TRAIL signaling	R-HSA-75158	5.638919e-01	0.249	0	0
Ceramide signalling	R-HSA-193681	5.638919e-01	0.249	0	0
Phosphorylation of Emi1	R-HSA-176417	5.638919e-01	0.249	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.638919e-01	0.249	0	0
Formation of the Editosome	R-HSA-75094	5.638919e-01	0.249	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	4.203322e-01	0.376	0	0
Negative regulation of MET activity	R-HSA-6807004	4.798482e-01	0.319	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	5.261936e-01	0.279	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.261936e-01	0.279	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.261936e-01	0.279	0	0
MAP kinase activation	R-HSA-450294	4.245385e-01	0.372	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	4.994161e-01	0.302	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	4.971593e-01	0.304	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.952207e-01	0.225	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	6.138658e-01	0.212	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	6.138658e-01	0.212	0	0
G2/M DNA damage checkpoint	R-HSA-69473	6.154178e-01	0.211	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	3.296671e-01	0.482	0	0
Signaling by NOTCH1	R-HSA-1980143	2.600071e-01	0.585	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.754366e-01	0.240	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	3.798838e-01	0.420	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	2.475343e-01	0.606	0	0
Neurexins and neuroligins	R-HSA-6794361	4.294449e-01	0.367	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	5.880503e-01	0.231	0	0
Signaling by MET	R-HSA-6806834	3.087946e-01	0.510	0	0
Metabolism of RNA	R-HSA-8953854	2.989511e-01	0.524	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	5.550988e-01	0.256	0	0
Interleukin-7 signaling	R-HSA-1266695	4.008481e-01	0.397	0	0
Sema4D in semaphorin signaling	R-HSA-400685	4.008481e-01	0.397	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.077862e-01	0.512	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	6.014844e-01	0.221	0	0
Interleukin-17 signaling	R-HSA-448424	5.597810e-01	0.252	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.879000e-01	0.231	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	3.781099e-01	0.422	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	3.534220e-01	0.452	0	0
Protein methylation	R-HSA-8876725	3.153185e-01	0.501	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	5.952207e-01	0.225	0	0
FLT3 signaling in disease	R-HSA-9682385	2.900300e-01	0.538	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.991838e-01	0.524	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	3.191517e-01	0.496	0	0
Signaling by PTK6	R-HSA-8848021	3.191517e-01	0.496	0	0
Cell junction organization	R-HSA-446728	3.107270e-01	0.508	0	0
CREB3 factors activate genes	R-HSA-8874211	2.397399e-01	0.620	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	3.713736e-01	0.430	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	4.403970e-01	0.356	0	0
ERK/MAPK targets	R-HSA-198753	5.056292e-01	0.296	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	5.754366e-01	0.240	0	0
HIV Life Cycle	R-HSA-162587	2.100849e-01	0.678	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	3.313617e-01	0.480	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	5.540746e-01	0.256	0	0
Activation of BH3-only proteins	R-HSA-114452	5.129796e-01	0.290	0	0
Negative regulation of FLT3	R-HSA-9706369	3.433966e-01	0.464	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	5.261936e-01	0.279	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	4.572298e-01	0.340	1	1
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	4.347056e-01	0.362	0	0
Adaptive Immune System	R-HSA-1280218	4.226336e-01	0.374	0	0
Signaling by NOTCH3	R-HSA-9012852	2.120858e-01	0.673	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.483063e-01	0.458	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.483063e-01	0.458	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.778810e-01	0.556	0	0
Signaling by LTK	R-HSA-9842663	4.941185e-01	0.306	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.638919e-01	0.249	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	5.568627e-01	0.254	0	0
Cell-Cell communication	R-HSA-1500931	2.603357e-01	0.584	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.141522e-01	0.669	0	0
HIV Infection	R-HSA-162906	5.758165e-01	0.240	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	3.596010e-01	0.444	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	2.194296e-01	0.659	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	5.402366e-01	0.267	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	5.402366e-01	0.267	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	3.312093e-01	0.480	0	0
Ovarian tumor domain proteases	R-HSA-5689896	3.077862e-01	0.512	0	0
Platelet homeostasis	R-HSA-418346	3.434604e-01	0.464	0	0
NGF-stimulated transcription	R-HSA-9031628	2.297084e-01	0.639	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	4.344218e-01	0.362	0	0
Signaling by TGFB family members	R-HSA-9006936	3.900327e-01	0.409	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.046569e-01	0.393	0	0
Sensory perception of sour taste	R-HSA-9729555	4.633238e-01	0.334	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	4.633238e-01	0.334	0	0
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	4.633238e-01	0.334	0	0
Tandem pore domain potassium channels	R-HSA-1296346	3.902031e-01	0.409	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.598678e-01	0.585	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	2.598678e-01	0.585	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	4.260168e-01	0.371	0	0
Inositol transporters	R-HSA-429593	5.162125e-01	0.287	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	5.162125e-01	0.287	0	0
Cardiogenesis	R-HSA-9733709	3.798838e-01	0.420	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.798838e-01	0.420	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	5.638919e-01	0.249	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	6.210883e-01	0.207	0	0
Netrin-1 signaling	R-HSA-373752	2.970539e-01	0.527	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.672824e-01	0.246	0	0
Biotin transport and metabolism	R-HSA-196780	5.860914e-01	0.232	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	3.902031e-01	0.409	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	3.544530e-01	0.450	0	0
Interleukin-12 family signaling	R-HSA-447115	4.114273e-01	0.386	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.397399e-01	0.620	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	2.778810e-01	0.556	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	3.312093e-01	0.480	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.909136e-01	0.408	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	3.433869e-01	0.464	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.568627e-01	0.254	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	6.068749e-01	0.217	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	2.598678e-01	0.585	0	0
Mitochondrial biogenesis	R-HSA-1592230	2.897898e-01	0.538	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.590958e-01	0.587	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	5.237679e-01	0.281	1	1
OAS antiviral response	R-HSA-8983711	4.941185e-01	0.306	0	0
Signaling by ALK in cancer	R-HSA-9700206	2.590958e-01	0.587	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.778810e-01	0.556	0	0
Sodium/Proton exchangers	R-HSA-425986	3.158896e-01	0.500	0	0
cGMP effects	R-HSA-418457	2.872872e-01	0.542	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	3.534220e-01	0.452	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.633238e-01	0.334	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	5.162125e-01	0.287	0	0
Co-inhibition by BTLA	R-HSA-9927353	5.162125e-01	0.287	0	0
NADPH regeneration	R-HSA-389542	6.068749e-01	0.217	0	0
Signaling by NOTCH4	R-HSA-9013694	4.776225e-01	0.321	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	4.918708e-01	0.308	0	0
Interleukin-1 family signaling	R-HSA-446652	4.967481e-01	0.304	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	3.433966e-01	0.464	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	5.056292e-01	0.296	0	0
Sensory processing of sound	R-HSA-9659379	5.476779e-01	0.261	0	0
Maturation of nucleoprotein	R-HSA-9683610	5.261936e-01	0.279	0	0
Other semaphorin interactions	R-HSA-416700	5.860914e-01	0.232	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	6.221647e-01	0.206	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	4.429441e-01	0.354	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	4.294449e-01	0.367	0	0
Mitophagy	R-HSA-5205647	6.144449e-01	0.212	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.902031e-01	0.409	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	3.312093e-01	0.480	0	0
Diseases of DNA repair	R-HSA-9675135	4.883438e-01	0.311	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.638919e-01	0.249	0	0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	5.638919e-01	0.249	0	0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	5.638919e-01	0.249	0	0
Signal regulatory protein family interactions	R-HSA-391160	5.568627e-01	0.254	0	0
Nef and signal transduction	R-HSA-164944	6.068749e-01	0.217	0	0
Formation of the anterior neural plate	R-HSA-9823739	5.860914e-01	0.232	0	0
Syndecan interactions	R-HSA-3000170	5.786942e-01	0.238	0	0
Signaling by ALK	R-HSA-201556	5.185672e-01	0.285	0	0
Influenza Infection	R-HSA-168255	2.484936e-01	0.605	0	0
Inflammasomes	R-HSA-622312	2.793877e-01	0.554	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	3.534220e-01	0.452	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.033168e-01	0.219	0	0
Interleukin-12 signaling	R-HSA-9020591	2.600071e-01	0.585	0	0
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	5.162125e-01	0.287	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.313553e-01	0.636	0	0
SARS-CoV-2 Infection	R-HSA-9694516	5.397609e-01	0.268	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.801652e-01	0.420	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	6.144449e-01	0.212	0	0
Gene Silencing by RNA	R-HSA-211000	3.546712e-01	0.450	0	0
Complex III assembly	R-HSA-9865881	6.014844e-01	0.221	0	0
Nephrin family interactions	R-HSA-373753	2.623388e-01	0.581	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	4.941185e-01	0.306	0	0
DNA Damage Reversal	R-HSA-73942	5.860914e-01	0.232	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	5.550988e-01	0.256	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	6.234462e-01	0.205	0	0
Long-term potentiation	R-HSA-9620244	6.234462e-01	0.205	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	6.234462e-01	0.205	0	0
EPHB-mediated forward signaling	R-HSA-3928662	6.258946e-01	0.203	0	0
G1 Phase	R-HSA-69236	6.258946e-01	0.203	0	0
Cyclin D associated events in G1	R-HSA-69231	6.258946e-01	0.203	0	0
Meiosis	R-HSA-1500620	6.263740e-01	0.203	0	0
Protein-protein interactions at synapses	R-HSA-6794362	6.263740e-01	0.203	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	6.306493e-01	0.200	0	0
Cellular response to hypoxia	R-HSA-1234174	6.319152e-01	0.199	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.319152e-01	0.199	0	0
Signalling to ERKs	R-HSA-187687	6.330909e-01	0.199	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	6.401886e-01	0.194	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.401886e-01	0.194	0	0
Disorders of Developmental Biology	R-HSA-9675151	6.401886e-01	0.194	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	6.401886e-01	0.194	0	0
Signaling by Hedgehog	R-HSA-5358351	6.403085e-01	0.194	0	0
DAG and IP3 signaling	R-HSA-1489509	6.423198e-01	0.192	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	6.445639e-01	0.191	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	6.445639e-01	0.191	0	0
TRP channels	R-HSA-3295583	6.445639e-01	0.191	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.456237e-01	0.190	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	6.456237e-01	0.190	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.456237e-01	0.190	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.456237e-01	0.190	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.456237e-01	0.190	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	6.456237e-01	0.190	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	6.456237e-01	0.190	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.456237e-01	0.190	0	0
Cysteine formation from homocysteine	R-HSA-1614603	6.456237e-01	0.190	0	0
Netrin mediated repulsion signals	R-HSA-418886	6.456237e-01	0.190	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	6.456237e-01	0.190	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.456237e-01	0.190	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.456237e-01	0.190	0	0
CHL1 interactions	R-HSA-447041	6.456237e-01	0.190	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	6.456237e-01	0.190	0	0
Maturation of replicase proteins	R-HSA-9694301	6.456237e-01	0.190	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	6.457351e-01	0.190	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.488295e-01	0.188	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	6.510533e-01	0.186	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	6.510533e-01	0.186	0	0
PRC2 methylates histones and DNA	R-HSA-212300	6.511445e-01	0.186	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	6.511445e-01	0.186	0	0
RNA Polymerase III Transcription	R-HSA-74158	6.511445e-01	0.186	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	6.545972e-01	0.184	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	6.582874e-01	0.182	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	6.582874e-01	0.182	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	6.582874e-01	0.182	0	0
Cardiac conduction	R-HSA-5576891	6.607646e-01	0.180	0	0
Adherens junctions interactions	R-HSA-418990	6.611970e-01	0.180	0	0
Cristae formation	R-HSA-8949613	6.648292e-01	0.177	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.650761e-01	0.177	0	0
Glycogen storage diseases	R-HSA-3229121	6.650761e-01	0.177	0	0
Specification of primordial germ cells	R-HSA-9827857	6.650761e-01	0.177	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	6.671247e-01	0.176	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	6.685952e-01	0.175	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	6.737882e-01	0.171	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	6.737882e-01	0.171	0	0
Peptide chain elongation	R-HSA-156902	6.745453e-01	0.171	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	6.779925e-01	0.169	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.793751e-01	0.168	0	0
Regulation by c-FLIP	R-HSA-3371378	6.805553e-01	0.167	0	0
RSK activation	R-HSA-444257	6.805553e-01	0.167	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	6.805553e-01	0.167	0	0
Dimerization of procaspase-8	R-HSA-69416	6.805553e-01	0.167	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.805553e-01	0.167	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.805553e-01	0.167	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.805553e-01	0.167	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	6.805553e-01	0.167	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.805553e-01	0.167	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.805553e-01	0.167	0	0
Co-stimulation by ICOS	R-HSA-9927354	6.805553e-01	0.167	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	6.805553e-01	0.167	0	0
Nucleotide salvage defects	R-HSA-9734207	6.805553e-01	0.167	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	6.805553e-01	0.167	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	6.805553e-01	0.167	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	6.805553e-01	0.167	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.805553e-01	0.167	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	6.805553e-01	0.167	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	6.842392e-01	0.165	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.854365e-01	0.164	0	0
Ephrin signaling	R-HSA-3928664	6.885554e-01	0.162	0	0
Mismatch Repair	R-HSA-5358508	6.885554e-01	0.162	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.885554e-01	0.162	0	0
Nephron development	R-HSA-9831926	6.885554e-01	0.162	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.885554e-01	0.162	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	6.888157e-01	0.162	0	0
Metal ion SLC transporters	R-HSA-425410	6.888157e-01	0.162	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.923620e-01	0.160	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.923620e-01	0.160	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.923620e-01	0.160	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	6.931788e-01	0.159	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	6.931788e-01	0.159	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	6.980014e-01	0.156	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	6.980014e-01	0.156	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.985095e-01	0.156	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	7.016649e-01	0.154	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	7.027971e-01	0.153	0	0
DARPP-32 events	R-HSA-180024	7.027971e-01	0.153	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.027971e-01	0.153	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	7.027971e-01	0.153	0	0
DNA Damage Bypass	R-HSA-73893	7.033652e-01	0.153	0	0
Degradation of CDH1	R-HSA-9766229	7.033652e-01	0.153	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.064428e-01	0.151	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	7.064428e-01	0.151	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.084609e-01	0.150	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	7.102387e-01	0.149	0	0
Regulation of mitotic cell cycle	R-HSA-453276	7.102387e-01	0.149	0	0
Translesion Synthesis by POLH	R-HSA-110320	7.106624e-01	0.148	0	0
Germ layer formation at gastrulation	R-HSA-9754189	7.106624e-01	0.148	0	0
Pyrimidine biosynthesis	R-HSA-500753	7.106624e-01	0.148	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	7.106624e-01	0.148	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	7.106624e-01	0.148	0	0
Specification of the neural plate border	R-HSA-9834899	7.106624e-01	0.148	0	0
Other interleukin signaling	R-HSA-449836	7.106624e-01	0.148	0	0
Maturation of nucleoprotein	R-HSA-9694631	7.106624e-01	0.148	0	0
CASP8 activity is inhibited	R-HSA-5218900	7.120454e-01	0.147	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.120454e-01	0.147	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.120454e-01	0.147	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.120454e-01	0.147	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	7.120454e-01	0.147	0	0
MAPK1 (ERK2) activation	R-HSA-112411	7.120454e-01	0.147	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.120454e-01	0.147	0	0
Unwinding of DNA	R-HSA-176974	7.120454e-01	0.147	0	0
mRNA Editing	R-HSA-75072	7.120454e-01	0.147	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	7.120454e-01	0.147	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	7.120454e-01	0.147	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.120454e-01	0.147	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	7.172800e-01	0.144	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.172800e-01	0.144	0	0
Diseases of Immune System	R-HSA-5260271	7.172800e-01	0.144	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.172800e-01	0.144	0	0
PI3K Cascade	R-HSA-109704	7.174342e-01	0.144	0	0
TCR signaling	R-HSA-202403	7.182040e-01	0.144	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.193117e-01	0.143	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.205101e-01	0.142	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	7.205101e-01	0.142	0	0
HCMV Late Events	R-HSA-9610379	7.262116e-01	0.139	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	7.310221e-01	0.136	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.314392e-01	0.136	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	7.314392e-01	0.136	0	0
Glycogen synthesis	R-HSA-3322077	7.314392e-01	0.136	0	0
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	7.314392e-01	0.136	0	0
Signal transduction by L1	R-HSA-445144	7.314392e-01	0.136	0	0
Creatine metabolism	R-HSA-71288	7.314392e-01	0.136	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.317839e-01	0.136	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.317839e-01	0.136	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	7.330862e-01	0.135	0	0
Generic Transcription Pathway	R-HSA-212436	7.331357e-01	0.135	1	0
Downstream signal transduction	R-HSA-186763	7.373899e-01	0.132	0	0
Molecules associated with elastic fibres	R-HSA-2129379	7.373899e-01	0.132	0	0
Budding and maturation of HIV virion	R-HSA-162588	7.373899e-01	0.132	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.404330e-01	0.131	0	0
DNA replication initiation	R-HSA-68952	7.404330e-01	0.131	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	7.404330e-01	0.131	0	0
Regulation of the apoptosome activity	R-HSA-9627069	7.404330e-01	0.131	0	0
Formation of apoptosome	R-HSA-111458	7.404330e-01	0.131	0	0
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	7.404330e-01	0.131	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	7.404330e-01	0.131	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.404330e-01	0.131	0	0
Interleukin-27 signaling	R-HSA-9020956	7.404330e-01	0.131	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	7.404330e-01	0.131	0	0
Sperm Motility And Taxes	R-HSA-1300642	7.404330e-01	0.131	0	0
MAPK3 (ERK1) activation	R-HSA-110056	7.404330e-01	0.131	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	7.404330e-01	0.131	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	7.404330e-01	0.131	0	0
Josephin domain DUBs	R-HSA-5689877	7.404330e-01	0.131	0	0
Pexophagy	R-HSA-9664873	7.404330e-01	0.131	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	7.441298e-01	0.128	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.441298e-01	0.128	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	7.441298e-01	0.128	0	0
Signaling by FGFR in disease	R-HSA-1226099	7.449292e-01	0.128	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.461639e-01	0.127	0	0
Hemostasis	R-HSA-109582	7.462465e-01	0.127	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.492654e-01	0.125	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.509334e-01	0.124	0	0
Lagging Strand Synthesis	R-HSA-69186	7.509334e-01	0.124	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.509334e-01	0.124	0	0
MITF-M-dependent gene expression	R-HSA-9856651	7.530278e-01	0.123	0	0
DNA strand elongation	R-HSA-69190	7.534515e-01	0.123	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	7.550563e-01	0.122	0	0
Insulin receptor signalling cascade	R-HSA-74751	7.555379e-01	0.122	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.567600e-01	0.121	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	7.570449e-01	0.121	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	7.582119e-01	0.120	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.588991e-01	0.120	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	7.589023e-01	0.120	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	7.604791e-01	0.119	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.660236e-01	0.116	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.660236e-01	0.116	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	7.660236e-01	0.116	0	0
Synthesis of PI	R-HSA-1483226	7.660236e-01	0.116	0	0
Bicarbonate transporters	R-HSA-425381	7.660236e-01	0.116	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	7.660236e-01	0.116	0	0
Chylomicron assembly	R-HSA-8963888	7.660236e-01	0.116	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.660236e-01	0.116	0	0
Suppression of apoptosis	R-HSA-9635465	7.660236e-01	0.116	0	0
UCH proteinases	R-HSA-5689603	7.663647e-01	0.116	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	7.680805e-01	0.115	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	7.682703e-01	0.114	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	7.687125e-01	0.114	0	0
G-protein beta:gamma signalling	R-HSA-397795	7.687125e-01	0.114	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.687125e-01	0.114	0	0
Activation of ATR in response to replication stress	R-HSA-176187	7.687125e-01	0.114	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	7.689168e-01	0.114	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.691958e-01	0.114	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.691958e-01	0.114	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.691958e-01	0.114	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	7.691958e-01	0.114	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	7.691958e-01	0.114	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.691958e-01	0.114	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.691958e-01	0.114	0	0
Assembly Of The HIV Virion	R-HSA-175474	7.691958e-01	0.114	0	0
Defective pyroptosis	R-HSA-9710421	7.736860e-01	0.111	0	0
Signaling by FGFR4	R-HSA-5654743	7.736860e-01	0.111	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.806053e-01	0.108	0	0
HDACs deacetylate histones	R-HSA-3214815	7.806053e-01	0.108	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.824495e-01	0.107	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.824495e-01	0.107	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.824495e-01	0.107	0	0
G1/S Transition	R-HSA-69206	7.824495e-01	0.107	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.862797e-01	0.104	0	0
FGFR2 alternative splicing	R-HSA-6803529	7.862797e-01	0.104	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.862797e-01	0.104	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	7.862797e-01	0.104	0	0
LDL clearance	R-HSA-8964038	7.862797e-01	0.104	0	0
RMTs methylate histone arginines	R-HSA-3214858	7.863123e-01	0.104	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.871358e-01	0.104	0	0
SARS-CoV-1 Infection	R-HSA-9678108	7.881049e-01	0.103	0	0
DNA Double Strand Break Response	R-HSA-5693606	7.882210e-01	0.103	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	7.890925e-01	0.103	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.890925e-01	0.103	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.890925e-01	0.103	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.890925e-01	0.103	0	0
ERKs are inactivated	R-HSA-202670	7.890925e-01	0.103	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.890925e-01	0.103	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.890925e-01	0.103	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.890925e-01	0.103	0	0
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.890925e-01	0.103	0	0
Ion homeostasis	R-HSA-5578775	7.918321e-01	0.101	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.918321e-01	0.101	0	0
Signaling by FGFR1	R-HSA-5654736	7.918321e-01	0.101	0	0
Dual Incision in GG-NER	R-HSA-5696400	7.969161e-01	0.099	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	7.969161e-01	0.099	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	7.969161e-01	0.099	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.969161e-01	0.099	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	7.983698e-01	0.098	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	7.983698e-01	0.098	0	0
Signaling by FGFR3	R-HSA-5654741	7.983698e-01	0.098	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	8.010015e-01	0.096	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	8.022400e-01	0.096	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	8.022400e-01	0.096	0	0
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	8.022400e-01	0.096	0	0
Formation of the ureteric bud	R-HSA-9830674	8.022400e-01	0.096	0	0
IRS-mediated signalling	R-HSA-112399	8.026047e-01	0.095	0	0
Downstream TCR signaling	R-HSA-202424	8.037116e-01	0.095	0	0
Homology Directed Repair	R-HSA-5693538	8.039035e-01	0.095	0	0
Signaling by NOTCH	R-HSA-157118	8.049803e-01	0.094	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.059053e-01	0.094	0	0
Cell-cell junction organization	R-HSA-421270	8.077229e-01	0.093	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	8.098715e-01	0.092	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	8.098715e-01	0.092	0	0
Signaling by TGFBR3	R-HSA-9839373	8.098715e-01	0.092	0	0
Scavenging by Class F Receptors	R-HSA-3000484	8.098882e-01	0.092	0	0
Repression of WNT target genes	R-HSA-4641265	8.098882e-01	0.092	0	0
GRB2 events in EGFR signaling	R-HSA-179812	8.098882e-01	0.092	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	8.098882e-01	0.092	0	0
Interleukin-35 Signalling	R-HSA-8984722	8.098882e-01	0.092	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	8.098882e-01	0.092	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	8.098882e-01	0.092	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.098882e-01	0.092	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.098882e-01	0.092	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	8.098882e-01	0.092	0	0
Pervasive developmental disorders	R-HSA-9005895	8.098882e-01	0.092	0	0
Disorders of Nervous System Development	R-HSA-9697154	8.098882e-01	0.092	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.112999e-01	0.091	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.112999e-01	0.091	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	8.121784e-01	0.090	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	8.121784e-01	0.090	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.129313e-01	0.090	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	8.141239e-01	0.089	0	0
Interleukin-6 family signaling	R-HSA-6783589	8.171322e-01	0.088	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.171322e-01	0.088	0	0
Plasma lipoprotein assembly	R-HSA-8963898	8.171322e-01	0.088	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	8.171322e-01	0.088	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	8.190463e-01	0.087	0	0
Selenocysteine synthesis	R-HSA-2408557	8.190463e-01	0.087	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	8.208315e-01	0.086	0	0
Toll-like Receptor Cascades	R-HSA-168898	8.209181e-01	0.086	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	8.221836e-01	0.085	0	0
GPVI-mediated activation cascade	R-HSA-114604	8.221836e-01	0.085	0	0
Calmodulin induced events	R-HSA-111933	8.221836e-01	0.085	0	0
CaM pathway	R-HSA-111997	8.221836e-01	0.085	0	0
Glycosphingolipid transport	R-HSA-9845576	8.221836e-01	0.085	0	0
Regulation of beta-cell development	R-HSA-186712	8.228213e-01	0.085	0	0
tRNA processing	R-HSA-72306	8.233651e-01	0.084	0	0
Signaling by Interleukins	R-HSA-449147	8.244874e-01	0.084	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	8.254669e-01	0.083	0	0
Reproduction	R-HSA-1474165	8.256399e-01	0.083	0	0
EPH-Ephrin signaling	R-HSA-2682334	8.282705e-01	0.082	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	8.286345e-01	0.082	0	0
Adenylate cyclase activating pathway	R-HSA-170660	8.286345e-01	0.082	0	0
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	8.286345e-01	0.082	0	0
Chylomicron remodeling	R-HSA-8963901	8.286345e-01	0.082	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.286345e-01	0.082	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.286345e-01	0.082	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.286345e-01	0.082	0	0
Processing of SMDT1	R-HSA-8949664	8.286345e-01	0.082	0	0
Diseases of nucleotide metabolism	R-HSA-9735804	8.286345e-01	0.082	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	8.286345e-01	0.082	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.286345e-01	0.082	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.286345e-01	0.082	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	8.291988e-01	0.081	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.310115e-01	0.080	0	0
Hyaluronan degradation	R-HSA-2160916	8.310115e-01	0.080	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	8.312647e-01	0.080	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.322417e-01	0.080	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.322417e-01	0.080	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	8.330523e-01	0.079	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	8.389293e-01	0.076	0	0
Opioid Signalling	R-HSA-111885	8.410307e-01	0.075	0	0
PLC beta mediated events	R-HSA-112043	8.413309e-01	0.075	0	0
Switching of origins to a post-replicative state	R-HSA-69052	8.434179e-01	0.074	0	0
Metalloprotease DUBs	R-HSA-5689901	8.439329e-01	0.074	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.439329e-01	0.074	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.439329e-01	0.074	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	8.439329e-01	0.074	0	0
Elastic fibre formation	R-HSA-1566948	8.447176e-01	0.073	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	8.447289e-01	0.073	0	0
Removal of the Flap Intermediate	R-HSA-69166	8.455333e-01	0.073	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.455333e-01	0.073	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.455333e-01	0.073	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	8.455333e-01	0.073	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	8.455333e-01	0.073	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.455333e-01	0.073	0	0
Glycerophospholipid catabolism	R-HSA-6814848	8.455333e-01	0.073	0	0
HDL assembly	R-HSA-8963896	8.455333e-01	0.073	0	0
Zinc transporters	R-HSA-435354	8.455333e-01	0.073	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.455333e-01	0.073	0	0
RSV-host interactions	R-HSA-9833110	8.478758e-01	0.072	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	8.503673e-01	0.070	0	0
Pentose phosphate pathway	R-HSA-71336	8.550256e-01	0.068	0	0
Plasma lipoprotein clearance	R-HSA-8964043	8.550256e-01	0.068	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	8.559504e-01	0.068	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.559504e-01	0.068	0	0
Triglyceride biosynthesis	R-HSA-75109	8.559504e-01	0.068	0	0
Insulin processing	R-HSA-264876	8.559504e-01	0.068	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.559504e-01	0.068	0	0
Maturation of hRSV A proteins	R-HSA-9828806	8.559504e-01	0.068	0	0
Eukaryotic Translation Termination	R-HSA-72764	8.572074e-01	0.067	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	8.595618e-01	0.066	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.607666e-01	0.065	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.607666e-01	0.065	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.607666e-01	0.065	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.607666e-01	0.065	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.607666e-01	0.065	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.607666e-01	0.065	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	8.607666e-01	0.065	0	0
Processive synthesis on the lagging strand	R-HSA-69183	8.607666e-01	0.065	0	0
Translesion synthesis by REV1	R-HSA-110312	8.607666e-01	0.065	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	8.607666e-01	0.065	0	0
p38MAPK events	R-HSA-171007	8.607666e-01	0.065	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	8.607666e-01	0.065	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	8.607666e-01	0.065	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	8.607666e-01	0.065	0	0
Phospholipid metabolism	R-HSA-1483257	8.636738e-01	0.064	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.637935e-01	0.064	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	8.647301e-01	0.063	0	0
Generation of second messenger molecules	R-HSA-202433	8.647301e-01	0.063	0	0
Glycogen metabolism	R-HSA-8982491	8.647301e-01	0.063	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	8.647301e-01	0.063	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	8.647301e-01	0.063	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	8.647301e-01	0.063	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	8.649145e-01	0.063	0	0
HIV elongation arrest and recovery	R-HSA-167287	8.671164e-01	0.062	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	8.671164e-01	0.062	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	8.671164e-01	0.062	0	0
Estrogen-dependent gene expression	R-HSA-9018519	8.674834e-01	0.062	0	0
Integration of energy metabolism	R-HSA-163685	8.674834e-01	0.062	0	0
Pyruvate metabolism	R-HSA-70268	8.678119e-01	0.062	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	8.680483e-01	0.061	0	0
G2/M Checkpoints	R-HSA-69481	8.687319e-01	0.061	0	0
Platelet degranulation	R-HSA-114608	8.687319e-01	0.061	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.711819e-01	0.060	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.738579e-01	0.059	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	8.738579e-01	0.059	0	0
Translesion synthesis by POLI	R-HSA-5656121	8.744984e-01	0.058	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	8.744984e-01	0.058	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.744984e-01	0.058	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.744984e-01	0.058	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.744984e-01	0.058	0	0
Atorvastatin ADME	R-HSA-9754706	8.744984e-01	0.058	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	8.744984e-01	0.058	0	0
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	8.744984e-01	0.058	0	0
Attachment and Entry	R-HSA-9678110	8.744984e-01	0.058	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.759545e-01	0.058	1	0
Regulation of PTEN stability and activity	R-HSA-8948751	8.760900e-01	0.057	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	8.774821e-01	0.057	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.774821e-01	0.057	0	0
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	8.774821e-01	0.057	0	0
Glucagon-type ligand receptors	R-HSA-420092	8.774821e-01	0.057	0	0
Neutrophil degranulation	R-HSA-6798695	8.796902e-01	0.056	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	8.801556e-01	0.055	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.824357e-01	0.054	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.824357e-01	0.054	0	0
Translesion synthesis by POLK	R-HSA-5655862	8.868766e-01	0.052	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	8.868766e-01	0.052	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.868766e-01	0.052	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.868766e-01	0.052	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	8.868766e-01	0.052	0	0
Phase 2 - plateau phase	R-HSA-5576893	8.868766e-01	0.052	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.868766e-01	0.052	0	0
Synthesis of PG	R-HSA-1483148	8.868766e-01	0.052	0	0
Coenzyme A biosynthesis	R-HSA-196783	8.868766e-01	0.052	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	8.868766e-01	0.052	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	8.868766e-01	0.052	0	0
DAP12 signaling	R-HSA-2424491	8.870965e-01	0.052	0	0
Activation of the pre-replicative complex	R-HSA-68962	8.870965e-01	0.052	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.870965e-01	0.052	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.870965e-01	0.052	0	0
G-protein mediated events	R-HSA-112040	8.874985e-01	0.052	0	0
Kidney development	R-HSA-9830369	8.874985e-01	0.052	0	0
ESR-mediated signaling	R-HSA-8939211	8.885485e-01	0.051	0	0
SARS-CoV Infections	R-HSA-9679506	8.903112e-01	0.050	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.904896e-01	0.050	0	0
Ca-dependent events	R-HSA-111996	8.904896e-01	0.050	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.922926e-01	0.049	0	0
Signaling by FGFR2	R-HSA-5654738	8.924117e-01	0.049	0	0
Interleukin-1 signaling	R-HSA-9020702	8.931099e-01	0.049	0	0
Regulated Necrosis	R-HSA-5218859	8.939518e-01	0.049	0	0
Adipogenesis	R-HSA-9843745	8.940398e-01	0.049	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.951067e-01	0.048	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.960071e-01	0.048	0	0
Cargo concentration in the ER	R-HSA-5694530	8.960071e-01	0.048	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.960071e-01	0.048	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.980347e-01	0.047	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.980347e-01	0.047	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.980347e-01	0.047	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	8.980347e-01	0.047	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.980347e-01	0.047	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.980347e-01	0.047	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.029719e-01	0.044	0	0
Viral mRNA Translation	R-HSA-192823	9.032602e-01	0.044	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.042591e-01	0.044	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.051284e-01	0.043	0	0
Amine ligand-binding receptors	R-HSA-375280	9.051284e-01	0.043	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.059032e-01	0.043	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.076245e-01	0.042	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.080417e-01	0.042	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	9.080927e-01	0.042	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	9.080927e-01	0.042	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.080927e-01	0.042	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	9.080927e-01	0.042	0	0
PKA activation in glucagon signalling	R-HSA-164378	9.080927e-01	0.042	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	9.080927e-01	0.042	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	9.080927e-01	0.042	0	0
Apoptotic factor-mediated response	R-HSA-111471	9.080927e-01	0.042	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	9.080927e-01	0.042	0	0
PKA activation	R-HSA-163615	9.080927e-01	0.042	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.080927e-01	0.042	0	0
Tie2 Signaling	R-HSA-210993	9.080927e-01	0.042	0	0
SLC transporter disorders	R-HSA-5619102	9.097002e-01	0.041	0	0
Hedgehog 'on' state	R-HSA-5632684	9.114254e-01	0.040	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.117631e-01	0.040	0	0
Nucleosome assembly	R-HSA-774815	9.117631e-01	0.040	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	9.117631e-01	0.040	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.117631e-01	0.040	0	0
Fanconi Anemia Pathway	R-HSA-6783310	9.117631e-01	0.040	0	0
Triglyceride metabolism	R-HSA-8979227	9.159457e-01	0.038	0	0
Extension of Telomeres	R-HSA-180786	9.159457e-01	0.038	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.159457e-01	0.038	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.159457e-01	0.038	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.171591e-01	0.038	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	9.171591e-01	0.038	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	9.171591e-01	0.038	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	9.171591e-01	0.038	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	9.171591e-01	0.038	0	0
Diseases of hemostasis	R-HSA-9671793	9.171591e-01	0.038	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	9.171591e-01	0.038	0	0
HDL remodeling	R-HSA-8964058	9.171591e-01	0.038	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.171591e-01	0.038	0	0
STING mediated induction of host immune responses	R-HSA-1834941	9.171591e-01	0.038	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.171591e-01	0.038	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	9.189579e-01	0.037	0	0
Miscellaneous transport and binding events	R-HSA-5223345	9.189579e-01	0.037	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	9.189579e-01	0.037	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	9.189629e-01	0.037	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.209750e-01	0.036	0	0
Interferon gamma signaling	R-HSA-877300	9.218158e-01	0.035	0	0
Synthesis of DNA	R-HSA-69239	9.251220e-01	0.034	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.253317e-01	0.034	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	9.253317e-01	0.034	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.253317e-01	0.034	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.253317e-01	0.034	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.253317e-01	0.034	0	0
Protein hydroxylation	R-HSA-9629569	9.253317e-01	0.034	0	0
Signaling by NODAL	R-HSA-1181150	9.253317e-01	0.034	0	0
Signal amplification	R-HSA-392518	9.254847e-01	0.034	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.254847e-01	0.034	0	0
Hyaluronan metabolism	R-HSA-2142845	9.254847e-01	0.034	0	0
Signaling by ERBB4	R-HSA-1236394	9.263198e-01	0.033	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.264283e-01	0.033	0	0
Gastrulation	R-HSA-9758941	9.270922e-01	0.033	0	0
GPER1 signaling	R-HSA-9634597	9.292114e-01	0.032	0	0
Gluconeogenesis	R-HSA-70263	9.292114e-01	0.032	0	0
Protein ubiquitination	R-HSA-8852135	9.307654e-01	0.031	0	0
Signaling by PDGF	R-HSA-186797	9.312149e-01	0.031	0	0
Mitochondrial protein import	R-HSA-1268020	9.312149e-01	0.031	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.312149e-01	0.031	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	9.312149e-01	0.031	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.315131e-01	0.031	0	0
PERK regulates gene expression	R-HSA-381042	9.315131e-01	0.031	0	0
G-protein activation	R-HSA-202040	9.326984e-01	0.030	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.326984e-01	0.030	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.326984e-01	0.030	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.326984e-01	0.030	0	0
Signalling to RAS	R-HSA-167044	9.326984e-01	0.030	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.326984e-01	0.030	0	0
Abacavir metabolism	R-HSA-2161541	9.326984e-01	0.030	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.326984e-01	0.030	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.326984e-01	0.030	0	0
Signaling by FGFR	R-HSA-190236	9.336903e-01	0.030	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	9.349700e-01	0.029	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.357180e-01	0.029	0	0
Triglyceride catabolism	R-HSA-163560	9.370777e-01	0.028	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	9.393387e-01	0.027	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	9.393387e-01	0.027	0	0
Ribavirin ADME	R-HSA-9755088	9.393387e-01	0.027	0	0
Glutathione synthesis and recycling	R-HSA-174403	9.393387e-01	0.027	0	0
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.393387e-01	0.027	0	0
Attachment and Entry	R-HSA-9694614	9.393387e-01	0.027	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.407191e-01	0.027	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.422115e-01	0.026	0	0
Degradation of DVL	R-HSA-4641258	9.422115e-01	0.026	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.422115e-01	0.026	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.422115e-01	0.026	0	0
RNA Polymerase I Transcription	R-HSA-73864	9.426991e-01	0.026	0	0
Meiotic recombination	R-HSA-912446	9.434349e-01	0.025	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	9.453242e-01	0.024	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.453242e-01	0.024	0	0
Signaling by KIT in disease	R-HSA-9669938	9.453242e-01	0.024	0	0
Ethanol oxidation	R-HSA-71384	9.453242e-01	0.024	0	0
Purine salvage	R-HSA-74217	9.469452e-01	0.024	0	0
Formation of the cornified envelope	R-HSA-6809371	9.475363e-01	0.023	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	9.475534e-01	0.023	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.507194e-01	0.022	0	0
ABC transporters in lipid homeostasis	R-HSA-1369062	9.507194e-01	0.022	0	0
Biosynthesis of maresins	R-HSA-9018682	9.507194e-01	0.022	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.511728e-01	0.022	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	9.513077e-01	0.022	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.513077e-01	0.022	0	0
Stabilization of p53	R-HSA-69541	9.513077e-01	0.022	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	9.513913e-01	0.022	0	0
Signaling by Insulin receptor	R-HSA-74752	9.523585e-01	0.021	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.523585e-01	0.021	0	0
Transcription of the HIV genome	R-HSA-167172	9.544622e-01	0.020	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	9.546452e-01	0.020	0	0
Assembly of the pre-replicative complex	R-HSA-68867	9.551819e-01	0.020	0	0
HIV Transcription Elongation	R-HSA-167169	9.553263e-01	0.020	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	9.553263e-01	0.020	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.553263e-01	0.020	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.553263e-01	0.020	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.555826e-01	0.020	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.555826e-01	0.020	0	0
TNFs bind their physiological receptors	R-HSA-5669034	9.555826e-01	0.020	0	0
G alpha (z) signalling events	R-HSA-418597	9.582929e-01	0.019	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.585217e-01	0.018	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.585217e-01	0.018	0	0
Ribosome-associated quality control	R-HSA-9948299	9.589684e-01	0.018	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.590262e-01	0.018	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.590262e-01	0.018	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.590262e-01	0.018	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.590262e-01	0.018	0	0
Aflatoxin activation and detoxification	R-HSA-5423646	9.590262e-01	0.018	0	0
Maturation of spike protein	R-HSA-9694548	9.590262e-01	0.018	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.599660e-01	0.018	0	0
G protein gated Potassium channels	R-HSA-1296059	9.599660e-01	0.018	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	9.599660e-01	0.018	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.599660e-01	0.018	0	0
Tight junction interactions	R-HSA-420029	9.599660e-01	0.018	0	0
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.599660e-01	0.018	0	0
Acyl chain remodelling of PS	R-HSA-1482801	9.599660e-01	0.018	0	0
Fertilization	R-HSA-1187000	9.599660e-01	0.018	0	0
Formation of the nephric duct	R-HSA-9830364	9.599660e-01	0.018	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.599660e-01	0.018	0	0
Laminin interactions	R-HSA-3000157	9.599660e-01	0.018	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.599660e-01	0.018	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.604361e-01	0.018	0	0
Potential therapeutics for SARS	R-HSA-9679191	9.605379e-01	0.017	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	9.611609e-01	0.017	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.613884e-01	0.017	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.624313e-01	0.017	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.624313e-01	0.017	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.624313e-01	0.017	0	0
Intra-Golgi traffic	R-HSA-6811438	9.624313e-01	0.017	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.624313e-01	0.017	0	0
Translation of Structural Proteins	R-HSA-9683701	9.624313e-01	0.017	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.627661e-01	0.016	0	0
Developmental Biology	R-HSA-1266738	9.627931e-01	0.016	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.639172e-01	0.016	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.639172e-01	0.016	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	9.639172e-01	0.016	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.639172e-01	0.016	0	0
Abacavir ADME	R-HSA-2161522	9.639172e-01	0.016	0	0
Potassium Channels	R-HSA-1296071	9.650214e-01	0.015	0	0
Activation of GABAB receptors	R-HSA-991365	9.655636e-01	0.015	0	0
GABA B receptor activation	R-HSA-977444	9.655636e-01	0.015	0	0
DNA Replication Pre-Initiation	R-HSA-69002	9.668531e-01	0.015	0	0
Dual incision in TC-NER	R-HSA-6782135	9.669423e-01	0.015	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	9.674785e-01	0.014	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	9.674785e-01	0.014	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	9.674785e-01	0.014	0	0
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.674785e-01	0.014	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	9.674785e-01	0.014	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.674785e-01	0.014	0	0
Synthesis of PE	R-HSA-1483213	9.674785e-01	0.014	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.684439e-01	0.014	0	0
Chromosome Maintenance	R-HSA-73886	9.688984e-01	0.014	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	9.702650e-01	0.013	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	9.706886e-01	0.013	0	0
Formation of the Early Elongation Complex	R-HSA-113418	9.706886e-01	0.013	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.706886e-01	0.013	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.706886e-01	0.013	0	0
Pyrimidine salvage	R-HSA-73614	9.706886e-01	0.013	0	0
Prednisone ADME	R-HSA-9757110	9.706886e-01	0.013	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.706886e-01	0.013	0	0
DAP12 interactions	R-HSA-2172127	9.710912e-01	0.013	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.717358e-01	0.012	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.723379e-01	0.012	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.735237e-01	0.012	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.735237e-01	0.012	0	0
Somitogenesis	R-HSA-9824272	9.735237e-01	0.012	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	9.735237e-01	0.012	0	0
Thyroxine biosynthesis	R-HSA-209968	9.735820e-01	0.012	0	0
DNA methylation	R-HSA-5334118	9.735820e-01	0.012	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	9.735820e-01	0.012	0	0
Regulation of gene expression in beta cells	R-HSA-210745	9.735820e-01	0.012	0	0
mRNA Capping	R-HSA-72086	9.735820e-01	0.012	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.739702e-01	0.011	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.757578e-01	0.011	0	0
G alpha (s) signalling events	R-HSA-418555	9.758888e-01	0.011	0	0
Translation of Structural Proteins	R-HSA-9694635	9.760838e-01	0.011	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	9.761899e-01	0.010	0	0
Neurotransmitter clearance	R-HSA-112311	9.761899e-01	0.010	0	0
Synthesis of PC	R-HSA-1483191	9.778090e-01	0.010	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.785405e-01	0.009	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.793420e-01	0.009	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.796581e-01	0.009	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.796581e-01	0.009	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.796916e-01	0.009	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	9.806592e-01	0.008	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.806592e-01	0.008	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.806592e-01	0.008	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.809584e-01	0.008	0	0
Leishmania phagocytosis	R-HSA-9664417	9.815834e-01	0.008	0	0
Parasite infection	R-HSA-9664407	9.815834e-01	0.008	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.815834e-01	0.008	0	0
Extracellular matrix organization	R-HSA-1474244	9.816888e-01	0.008	0	0
Neuronal System	R-HSA-112316	9.824721e-01	0.008	1	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.825688e-01	0.008	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.826196e-01	0.008	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	9.830033e-01	0.007	0	0
Azathioprine ADME	R-HSA-9748787	9.830033e-01	0.007	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.833273e-01	0.007	0	0
Transmission across Chemical Synapses	R-HSA-112315	9.842225e-01	0.007	1	0
Vpu mediated degradation of CD4	R-HSA-180534	9.842900e-01	0.007	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.842900e-01	0.007	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.844561e-01	0.007	0	0
Stimuli-sensing channels	R-HSA-2672351	9.849169e-01	0.007	0	0
Immune System	R-HSA-168256	9.849815e-01	0.007	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	9.857878e-01	0.006	0	0
Orc1 removal from chromatin	R-HSA-68949	9.857878e-01	0.006	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.858413e-01	0.006	0	0
RA biosynthesis pathway	R-HSA-5365859	9.858413e-01	0.006	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.858413e-01	0.006	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.858413e-01	0.006	0	0
Cellular response to chemical stress	R-HSA-9711123	9.869263e-01	0.006	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.870082e-01	0.006	0	0
Telomere Maintenance	R-HSA-157579	9.870277e-01	0.006	0	0
rRNA processing	R-HSA-72312	9.872208e-01	0.006	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.872395e-01	0.006	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.872395e-01	0.006	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.872395e-01	0.006	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.872395e-01	0.006	0	0
Regulation of Apoptosis	R-HSA-169911	9.872395e-01	0.006	0	0
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.872395e-01	0.006	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.873197e-01	0.006	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.881262e-01	0.005	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.884997e-01	0.005	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.884997e-01	0.005	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.884997e-01	0.005	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.888103e-01	0.005	0	0
Paracetamol ADME	R-HSA-9753281	9.891502e-01	0.005	0	0
Cleavage of the damaged purine	R-HSA-110331	9.896355e-01	0.005	0	0
Degradation of AXIN	R-HSA-4641257	9.896355e-01	0.005	0	0
Collagen chain trimerization	R-HSA-8948216	9.896355e-01	0.005	0	0
Metabolism of folate and pterines	R-HSA-196757	9.896355e-01	0.005	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.900879e-01	0.004	0	0
Depurination	R-HSA-73927	9.906592e-01	0.004	0	0
Dectin-2 family	R-HSA-5621480	9.909462e-01	0.004	0	0
DNA Repair	R-HSA-73894	9.910378e-01	0.004	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.912104e-01	0.004	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.915819e-01	0.004	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.915819e-01	0.004	0	0
RAS processing	R-HSA-9648002	9.915819e-01	0.004	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.915916e-01	0.004	0	0
Neurotransmitter release cycle	R-HSA-112310	9.916458e-01	0.004	0	0
DNA Replication	R-HSA-69306	9.919984e-01	0.003	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.924134e-01	0.003	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.924134e-01	0.003	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.924134e-01	0.003	0	0
GABA receptor activation	R-HSA-977443	9.931080e-01	0.003	0	0
Nucleotide Excision Repair	R-HSA-5696398	9.932217e-01	0.003	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.933765e-01	0.003	0	0
Interleukin-10 signaling	R-HSA-6783783	9.934471e-01	0.003	0	0
ABC transporter disorders	R-HSA-5619084	9.934471e-01	0.003	0	0
PCP/CE pathway	R-HSA-4086400	9.934471e-01	0.003	0	0
Aquaporin-mediated transport	R-HSA-445717	9.937093e-01	0.003	0	0
Collagen degradation	R-HSA-1442490	9.937093e-01	0.003	0	0
Nucleotide salvage	R-HSA-8956321	9.937093e-01	0.003	0	0
HIV Transcription Initiation	R-HSA-167161	9.938383e-01	0.003	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.938383e-01	0.003	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.938383e-01	0.003	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.938383e-01	0.003	0	0
Heme biosynthesis	R-HSA-189451	9.938383e-01	0.003	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.943328e-01	0.002	0	0
Collagen formation	R-HSA-1474290	9.943328e-01	0.002	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.944471e-01	0.002	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	9.944471e-01	0.002	0	0
Depyrimidination	R-HSA-73928	9.944471e-01	0.002	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.944471e-01	0.002	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	9.949958e-01	0.002	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.949958e-01	0.002	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.952211e-01	0.002	0	0
Ion transport by P-type ATPases	R-HSA-936837	9.952211e-01	0.002	0	0
Proteasome assembly	R-HSA-9907900	9.954902e-01	0.002	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.954902e-01	0.002	0	0
Surfactant metabolism	R-HSA-5683826	9.954902e-01	0.002	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.959359e-01	0.002	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.960244e-01	0.002	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.961866e-01	0.002	0	0
Leishmania infection	R-HSA-9658195	9.961866e-01	0.002	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.963375e-01	0.002	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.964693e-01	0.002	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.966947e-01	0.001	0	0
Protein localization	R-HSA-9609507	9.966950e-01	0.001	0	0
Neddylation	R-HSA-8951664	9.970107e-01	0.001	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.973196e-01	0.001	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.974969e-01	0.001	0	0
Viral Infection Pathways	R-HSA-9824446	9.975495e-01	0.001	0	0
Purine catabolism	R-HSA-74259	9.977191e-01	0.001	0	0
Base Excision Repair	R-HSA-73884	9.978225e-01	0.001	0	0
Complex IV assembly	R-HSA-9864848	9.978234e-01	0.001	0	0
The phototransduction cascade	R-HSA-2514856	9.978234e-01	0.001	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.979218e-01	0.001	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	9.980385e-01	0.001	0	0
Iron uptake and transport	R-HSA-917937	9.982754e-01	0.001	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.986590e-01	0.001	0	0
Integrin cell surface interactions	R-HSA-216083	9.986975e-01	0.001	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.987066e-01	0.001	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.988141e-01	0.001	0	0
G alpha (q) signalling events	R-HSA-416476	9.988447e-01	0.001	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.989021e-01	0.000	0	0
PPARA activates gene expression	R-HSA-1989781	9.989609e-01	0.000	0	0
Peroxisomal protein import	R-HSA-9033241	9.990536e-01	0.000	0	0
Regulation of insulin secretion	R-HSA-422356	9.990857e-01	0.000	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.991008e-01	0.000	0	0
tRNA Aminoacylation	R-HSA-379724	9.991472e-01	0.000	0	0
Glutathione conjugation	R-HSA-156590	9.991472e-01	0.000	0	0
Metabolism of polyamines	R-HSA-351202	9.991472e-01	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.992536e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.993620e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.993675e-01	0.000	0	0
Complex I biogenesis	R-HSA-6799198	9.993761e-01	0.000	0	0
Xenobiotics	R-HSA-211981	9.994378e-01	0.000	0	0
Glycosphingolipid biosynthesis	R-HSA-9840309	9.994378e-01	0.000	0	0
Nicotinate metabolism	R-HSA-196807	9.995887e-01	0.000	0	0
Metabolism of steroid hormones	R-HSA-196071	9.995887e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.996184e-01	0.000	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.996294e-01	0.000	0	0
Glycosphingolipid catabolism	R-HSA-9840310	9.996991e-01	0.000	0	0
Retinoid metabolism and transport	R-HSA-975634	9.997289e-01	0.000	0	0
ECM proteoglycans	R-HSA-3000178	9.997289e-01	0.000	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	9.997289e-01	0.000	0	0
Metabolism of cofactors	R-HSA-8978934	9.997289e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.997289e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.997393e-01	0.000	0	0
Ion channel transport	R-HSA-983712	9.997510e-01	0.000	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.997557e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.997799e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.997847e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.997950e-01	0.000	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.998017e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.998222e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.998454e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.998693e-01	0.000	0	0
Cholesterol biosynthesis	R-HSA-191273	9.998693e-01	0.000	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	9.998939e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.998973e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999044e-01	0.000	0	0
Amyloid fiber formation	R-HSA-977225	9.999044e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999044e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999178e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999282e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.999282e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.999431e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.999489e-01	0.000	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.999489e-01	0.000	0	0
Translation	R-HSA-72766	9.999620e-01	0.000	0	0
ER-Phagosome pathway	R-HSA-1236974	9.999626e-01	0.000	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.999655e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999748e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.999881e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999886e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.999896e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999898e-01	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	9.999903e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999951e-01	0.000	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.999962e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999963e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999963e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999963e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999969e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999973e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999980e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999982e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999982e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999984e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999985e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999992e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999994e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999994e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999994e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999995e-01	0.000	0	0
Drug ADME	R-HSA-9748784	9.999997e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999998e-01	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999998e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999998e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.999999e-01	0.000	0	0
Post-translational protein modification	R-HSA-597592	9.999999e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999999e-01	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.999999e-01	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000	0	0
Disease	R-HSA-1643685	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0