LRRK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00429 T595 SIGNOR|PSP DNM1L DLP1 DRP1 GGVGDGVQEPTtGNWRGMLKtSKAEELLAEEKsKPIPIMPA
O15379 S424 PSP HDAC3 YSRPEAPNEFYDGDHDNDKEsDVEI________________
O43318 S439 Sugiyama MAP3K7 TAK1 GNILDVPEIVISGNGQPRRRsIQDLtVtGTEPGQVssRsss
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75061 S570 EPSD|PSP DNAJC6 KIAA0473 PSGPASTQSTPRRsATstsAsPtLRVGEGATFDPFGAPSKP
O95295 T117 SIGNOR|EPSD|PSP SNAPIN BLOC1S7 SNAP25BP SNAPAP NILQNAQERLRRLNHSVAKEtARRRAMLDsGIyPPGsPGK_
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P04637 T304 EPSD|PSP TP53 P53 tEEENLRKKGEPHHELPPGStKRALPNNTsssPQPKKKPLD
P04637 T377 EPSD|PSP TP53 P53 KEPGGSRAHssHLKsKKGQstsRHKKLMFKtEGPDsD____
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05067 T743 EPSD|PSP APP A4 AD1 LKKKQYtsIHHGVVEVDAAVtPEERHLSKMQQNGyENPtyK
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P15311 T567 EPSD|PSP EZR VIL2 RTHNDIIHNENMRQGRDKYKtLRQIRQGNTKQRIDEFEAL_
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16403 S36 Sugiyama H1-2 H1F2 HIST1H1C EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P26038 T558 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MSN KTANDMIHAENMRLGRDKYKtLRQIRQGNTKQRIDEFEsM_
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P30048 T146 SIGNOR PRDX3 AOP1 NCEVVAVSVDSHFSHLAWINtPRKNGGLGHMNIALLSDLTK
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31749 S473 SIGNOR|EPSD|PSP AKT1 PKB RAC DQDDSMECVDSERRPHFPQFsysAsGtA_____________
P35241 T564 EPSD|PSP RDX KTQNDVLHAENVKAGRDKYKtLRQIRQGNtKQRIDEFEAM_
P37840 S129 SIGNOR SNCA NACP PARK1 QEGILEDMPVDPDNEAyEMPsEEGyQDyEPEA_________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243 S195 Sugiyama MATR3 KIAA0723 RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46459 T645 SIGNOR|EPSD|PSP NSF ALLVLLKKAPPQGRKLLIIGtTSRKDVLQEMEMLNAFSTTI
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P61006 T72 GPS6|SIGNOR|PSP RAB8A MEL RAB8 LDGKRIKLQIWDtAGQERFRtITTAYYRGAMGIMLVYDITN
P61020 T6 SIGNOR|EPSD|PSP RAB5B _______________MTSRstARPNGQPQASKICQFKLVLL
P61026 T73 SIGNOR|PSP RAB10 LQGKKIKLQIWDtAGQERFHtIttsYYRGAMGIMLVYDITN
P62280 T28 EPSD|PSP RPS11 RAyQKQPtIFQNKKRVLLGEtGKEKLPRYYKNIGLGFKtPK
P62280 T46 EPSD|PSP RPS11 GEtGKEKLPRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNV
P62280 T54 EPSD|PSP RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62841 T136 EPSD|PSP RPS15 RIG LGEFSITYKPVKHGRPGIGAtHsSRFIPLK___________
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62937 T157 Sugiyama PPIA CYPA NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
Q08J23 S593 Sugiyama NSUN2 SAKI TRM4 NNSEKMKVINTGIKVWCRNNsGEEFDCAFRLAQEGIYTLYP
Q09161 S22 Sugiyama NCBP1 CBP80 NCBP SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q12982 S114 Sugiyama BNIP2 NIP2 EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR
Q13428 S87 Sugiyama TCOF1 EDAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRLAs
Q13501 T138 EPSD|PSP SQSTM1 ORCA OSIL PRNMVHPNVICDGCNGPVVGtRYKCSVCPDyDLCsVCEGKG
Q14155 T127 SIGNOR ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314 FDANDLYQGQNFNKVLSSLVtLNKVTADIGLGSDsVCARPs
Q14155 T164 SIGNOR ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314 ARPssHRIKsFDsLGsQsLHtRtsKLFQGQYRsLDMTDNSN
Q14671 S709 Sugiyama PUM1 KIAA0099 PUMH1 LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q3KQU3 S112 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 KsRGPtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEV
Q5S007 S1124 EPSD|PSP LRRK2 PARK8 DVVEKLEQLILEGNKISGICsPLRLKELKILNLSKNHISSL
Q5S007 S1253 EPSD|PSP LRRK2 PARK8 SILDLSEKAYLWSRVEKLHLsHNKLKEIPPEIGCLENLTSL
Q5S007 S1283 EPSD|PSP LRRK2 PARK8 EIGCLENLTSLDVSYNLELRsFPNEMGKLsKIWDLPLDELH
Q5S007 S1292 EPSD|PSP LRRK2 PARK8 SLDVSYNLELRsFPNEMGKLsKIWDLPLDELHLNFDFKHIG
Q5S007 S1345 EPSD|PSP LRRK2 PARK8 RLKKAVPyNRMKLMIVGNtGsGKtTLLQQLMKtKKSDLGMQ
Q5S007 S1403 SIGNOR|EPSD|PSP LRRK2 PARK8 KRKRDLVLNVWDFAGREEFystHPHFMtQRALYLAVYDLSK
Q5S007 S1443 EPSD|PSP LRRK2 PARK8 KGQAEVDAMKPWLFNIKARAsssPVILVGtHLDVsDEKQRK
Q5S007 S1444 EPSD|PSP LRRK2 PARK8 GQAEVDAMKPWLFNIKARAsssPVILVGtHLDVsDEKQRKA
Q5S007 S1445 EPSD|PSP|Sugiyama LRRK2 PARK8 QAEVDAMKPWLFNIKARAsssPVILVGtHLDVsDEKQRKAC
Q5S007 S1457 EPSD|PSP LRRK2 PARK8 NIKARAsssPVILVGtHLDVsDEKQRKACMsKItKELLNKR
Q5S007 S1467 EPSD|PSP LRRK2 PARK8 VILVGtHLDVsDEKQRKACMsKItKELLNKRGFPAIRDyHF
Q5S007 S1508 EPSD|PSP LRRK2 PARK8 VNAtEESDALAKLRKtIINEsLNFKIRDQLVVGQLIPDCYV
Q5S007 S1536 EPSD|PSP LRRK2 PARK8 QLVVGQLIPDCYVELEKIILsERKNVPIEFPVIDRKRLLQL
Q5S007 S1647 EPSD|PSP LRRK2 PARK8 sRRDVEKFLSKKRKFPKNYMsQYFKLLEKFQIALPIGEEYL
Q5S007 S1853 EPSD|PSP LRRK2 PARK8 KAEEGDLLVNPDQPRLtIPIsQIAPDLILADLPRNIMLNND
Q5S007 S1913 EPSD|PSP LRRK2 PARK8 VYRAAYEGEEVAVKIFNKHtsLRLLRQELVVLCHLHHPSLI
Q5S007 S2032 SIGNOR|EPSD|PSP LRRK2 PARK8 IAKIADyGIAQYCCRMGIKtsEGtPGFRAPEVARGNVIYNQ
Q5S007 S2166 Sugiyama LRRK2 PARK8 LPKNVIVECMVATHHNSRNAsIWLGCGHTDRGQLSFLDLNT
Q5S007 S2257 EPSD|PSP LRRK2 PARK8 TLEKMTDSVTCLYCNSFSKQsKQKNFLLVGTADGKLAIFED
Q5S007 S2370 Sugiyama LRRK2 PARK8 SDSNIITVVVDTALYIAKQNsPVVEVWDKKTEKLCGLIDCV
Q5S007 S3 EPSD|PSP LRRK2 PARK8 __________________MAsGsCQGCEEDEETLKKLIVRL
Q5S007 S5 EPSD|PSP LRRK2 PARK8 ________________MAsGsCQGCEEDEETLKKLIVRLNN
Q5S007 S910 PSP LRRK2 PARK8 SDDLDSEGSEGSFLVKKKsNsISVGEFYRDAVLQRCsPNLQ
Q5S007 S935 PSP LRRK2 PARK8 EFYRDAVLQRCsPNLQRHsNsLGPIFDHEDLLKRKRKILSs
Q5S007 S955 PSP LRRK2 PARK8 sLGPIFDHEDLLKRKRKILSsDDSLRSSKLQSHMRHsDsIs
Q5S007 S971 Sugiyama LRRK2 PARK8 KILSsDDSLRSSKLQSHMRHsDsIssLASEREYITSLDLSA
Q5S007 S973 PSP|Sugiyama LRRK2 PARK8 LSsDDSLRSSKLQSHMRHsDsIssLASEREYITSLDLSANE
Q5S007 S975 Sugiyama LRRK2 PARK8 sDDSLRSSKLQSHMRHsDsIssLASEREYITSLDLSANELR
Q5S007 S976 Sugiyama LRRK2 PARK8 DDSLRSSKLQSHMRHsDsIssLASEREYITSLDLSANELRD
Q5S007 T1343 EPSD|PSP LRRK2 PARK8 QQRLKKAVPyNRMKLMIVGNtGsGKtTLLQQLMKtKKSDLG
Q5S007 T1348 EPSD|PSP LRRK2 PARK8 KAVPyNRMKLMIVGNtGsGKtTLLQQLMKtKKSDLGMQSAt
Q5S007 T1357 EPSD|PSP LRRK2 PARK8 LMIVGNtGsGKtTLLQQLMKtKKSDLGMQSAtVGIDVKDWP
Q5S007 T1368 EPSD|PSP LRRK2 PARK8 tTLLQQLMKtKKSDLGMQSAtVGIDVKDWPIQIRDKRKRDL
Q5S007 T1404 SIGNOR|EPSD|PSP LRRK2 PARK8 RKRDLVLNVWDFAGREEFystHPHFMtQRALYLAVYDLSKG
Q5S007 T1410 SIGNOR|EPSD|PSP LRRK2 PARK8 LNVWDFAGREEFystHPHFMtQRALYLAVYDLSKGQAEVDA
Q5S007 T1452 EPSD|PSP LRRK2 PARK8 KPWLFNIKARAsssPVILVGtHLDVsDEKQRKACMsKItKE
Q5S007 T1470 EPSD|PSP LRRK2 PARK8 VGtHLDVsDEKQRKACMsKItKELLNKRGFPAIRDyHFVNA
Q5S007 T1491 SIGNOR|EPSD|PSP LRRK2 PARK8 KELLNKRGFPAIRDyHFVNAtEESDALAKLRKtIINEsLNF
Q5S007 T1503 EPSD|PSP LRRK2 PARK8 RDyHFVNAtEESDALAKLRKtIINEsLNFKIRDQLVVGQLI
Q5S007 T1612 EPSD|PSP LRRK2 PARK8 LSDLYFVEPKWLCKIMAQILtVKVEGCPKHPKGIIsRRDVE
Q5S007 T1849 EPSD|PSP LRRK2 PARK8 DLMKKAEEGDLLVNPDQPRLtIPIsQIAPDLILADLPRNIM
Q5S007 T1912 EPSD|PSP LRRK2 PARK8 SVYRAAYEGEEVAVKIFNKHtsLRLLRQELVVLCHLHHPSL
Q5S007 T1967 SIGNOR|EPSD|PSP LRRK2 PARK8 MELASKGSLDRLLQQDKASLtRtLQHRIALHVADGLRYLHS
Q5S007 T1969 SIGNOR|EPSD|PSP LRRK2 PARK8 LASKGSLDRLLQQDKASLtRtLQHRIALHVADGLRYLHSAM
Q5S007 T2031 SIGNOR|EPSD|PSP LRRK2 PARK8 IIAKIADyGIAQYCCRMGIKtsEGtPGFRAPEVARGNVIYN
Q5S007 T2035 SIGNOR|EPSD|PSP LRRK2 PARK8 IADyGIAQYCCRMGIKtsEGtPGFRAPEVARGNVIYNQQAD
Q5S007 T2483 EPSD|PSP LRRK2 PARK8 LGSLKNVMLVLGYNRKNTEGtQKQKEIQSCLTVWDINLPHE
Q5S007 T2524 EPSD|PSP LRRK2 PARK8 VQNLEKHIEVRKELAEKMRRtSVE_________________
Q5S007 T424 EPSD|PSP LRRK2 PARK8 SMLMHSSSKEVFQASANALStLLEQNVNFRKILLSKGIHLN
Q5S007 T524 EPSD|PSP LRRK2 PARK8 ALRAILHFIVPGMPEESREDtEFHHKLNMVKKQCFKNDIHK
Q5S007 T776 EPSD|PSP LRRK2 PARK8 KLVELLLNSGSREQDVRKALtISIGKGDSQIISLLLRRLAL
Q5S007 T826 EPSD|PSP LRRK2 PARK8 GGFCIGKVEPSWLGPLFPDKtSNLRKQtNIAStLARMVIRY
Q5S007 T833 EPSD|PSP LRRK2 PARK8 VEPSWLGPLFPDKtSNLRKQtNIAStLARMVIRYQMKSAVE
Q5S007 T838 EPSD|PSP LRRK2 PARK8 LGPLFPDKtSNLRKQtNIAStLARMVIRYQMKSAVEEGTAS
Q5S007 Y1332 EPSD|PSP LRRK2 PARK8 GCKAKDIIRFLQQRLKKAVPyNRMKLMIVGNtGsGKtTLLQ
Q5S007 Y1402 EPSD|PSP LRRK2 PARK8 DKRKRDLVLNVWDFAGREEFystHPHFMtQRALYLAVYDLS
Q5S007 Y1485 EPSD|PSP LRRK2 PARK8 CMsKItKELLNKRGFPAIRDyHFVNAtEESDALAKLRKtII
Q5T0N5 S488 Sugiyama FNBP1L C1orf39 TOCA1 NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD
Q5T0N5 S489 Sugiyama FNBP1L C1orf39 TOCA1 EAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytDD
Q6GYQ0 S860 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 DEFIAERLRSGNASTMTRRGssPGsLEIPKDLPDILNKQNQ
Q6ZN18 S206 Sugiyama AEBP2 DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q6ZVN8 T290 Sugiyama HJV HFE2 RGMC PGNHVEIQAAYIGTTIIIRQtAGQLSFSIKVAEDVAMAFSA
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TE77 S37 Sugiyama SSH3 SSH3L tPVGPWDQAVQRRSRLQRRQsFAVLRGAVLGLQDGGDNDDA
Q96CW1 T156 PSP AP2M1 CLAPM1 KIAA0109 QGIKSQHQTKEEQSQItsQVtGQIGWRREGIKYRRNELFLD
Q96G46 T240 Sugiyama DUS3L KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96RU3 S497 Sugiyama FNBP1 FBP17 KIAA0554 AWLAEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREs
Q99683 T825 SIGNOR|EPSD|PSP MAP3K5 ASK1 MAPKKK5 MEKK5 KGDNVLINtYSGVLKISDFGtSKRLAGINPCTEtFTGtLQy
Q99683 T838 EPSD|PSP MAP3K5 ASK1 MAPKKK5 MEKK5 LKISDFGtSKRLAGINPCTEtFTGtLQyMAPEIIDKGPRGY
Q99962 S75 SIGNOR SH3GL2 CNSA2 SH3D2A IEyLQPNPAsRAKLSMINTMsKIRGQEKGPGYPQAEALLAE
Q9BTC0 S1456 Sugiyama DIDO1 C20orf158 DATF1 KIAA0333 EAKVTVDDLPNRMCADVRRNsVERPAEPVAGAAtPsLVEQQ
Q9BW61 S33 Sugiyama DDA1 C19orf58 PCIA1 KSNFSRFHADSVCKASNRRPsVYLPTREYPSEQIIVTEKTN
Q9BX95 T114 Sugiyama SGPP1 SPP1 AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9C0C2 S429 Sugiyama TNKS1BP1 KIAA1741 TAB182 EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9NPG1 T598 PSP FZD3 IHSKVSSYHGSLHRSRDGRYtPCSYRGMEERLPHGSMSRLT
Q9NSY1 S1029 Sugiyama BMP2K BIKE HRIHFB2017 KPTYRtPERARRHKKVGRRDsQssNEFLTIsDSKENISVAL
Q9P2J5 T293 SIGNOR|PSP LARS1 KIAA1352 LARS EPYPSKLSGLKGKNIFLVAAtLRPETMFGQTNCWVRPDMKY
Q9ULL1 S615 Sugiyama PLEKHG1 KIAA1209 STETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTRELQNSP
Q9UQ35 S1539 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9Y2I7 S307 Sugiyama PIKFYVE KIAA0981 PIP5K3 TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Axon guidance R-HSA-422475 8.448798e-10 9.073 0 0
Nervous system development R-HSA-9675108 7.756113e-09 8.110 0 0
Cell Cycle R-HSA-1640170 1.417128e-08 7.849 0 0
L1CAM interactions R-HSA-373760 1.797327e-07 6.745 0 0
Cell Cycle, Mitotic R-HSA-69278 2.633781e-07 6.579 0 0
Signal Transduction R-HSA-162582 2.384047e-07 6.623 1 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.991126e-07 6.399 0 0
Cellular Senescence R-HSA-2559583 3.770287e-07 6.424 0 0
Apoptotic execution phase R-HSA-75153 5.668178e-07 6.247 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.322754e-06 5.879 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.540898e-06 5.812 0 0
Oncogene Induced Senescence R-HSA-2559585 1.878873e-06 5.726 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.382749e-06 5.623 0 0
Recycling pathway of L1 R-HSA-437239 4.130238e-06 5.384 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.257562e-06 5.279 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.242217e-06 5.084 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.337910e-06 5.030 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.262500e-05 4.899 0 0
Signaling by ALK in cancer R-HSA-9700206 1.262500e-05 4.899 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.302126e-05 4.638 0 0
Developmental Biology R-HSA-1266738 2.290498e-05 4.640 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.500792e-05 4.602 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.506047e-05 4.455 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.139355e-05 4.383 0 0
G2/M Transition R-HSA-69275 5.624923e-05 4.250 0 0
Post NMDA receptor activation events R-HSA-438064 5.797693e-05 4.237 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.461944e-05 4.190 0 0
mRNA Splicing R-HSA-72172 7.390951e-05 4.131 0 0
Cell Cycle Checkpoints R-HSA-69620 1.147373e-04 3.940 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.228500e-04 3.911 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.228500e-04 3.911 0 0
Gene expression (Transcription) R-HSA-74160 1.356818e-04 3.867 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.481407e-04 3.829 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.662513e-04 3.779 0 0
Mitotic Anaphase R-HSA-68882 1.565977e-04 3.805 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.872606e-04 3.728 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.870974e-04 3.728 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.909143e-04 3.719 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.030043e-04 3.692 0 0
Apoptosis R-HSA-109581 2.164050e-04 3.665 0 0
mRNA 3'-end processing R-HSA-72187 2.290638e-04 3.640 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.278610e-04 3.642 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.315620e-04 3.635 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.468163e-04 3.608 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.043999e-04 3.517 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.358721e-04 3.474 0 0
PKR-mediated signaling R-HSA-9833482 3.488053e-04 3.457 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.640600e-04 3.439 0 0
Polo-like kinase mediated events R-HSA-156711 4.238175e-04 3.373 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.262464e-04 3.370 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.262464e-04 3.370 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.238175e-04 3.373 0 0
RNA Polymerase II Transcription R-HSA-73857 4.669395e-04 3.331 0 0
Cellular responses to stress R-HSA-2262752 5.081605e-04 3.294 0 0
Mitotic Prophase R-HSA-68875 5.360837e-04 3.271 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.831687e-04 3.234 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.528832e-04 3.185 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.711085e-04 3.173 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.477239e-04 3.126 0 0
M Phase R-HSA-68886 7.562737e-04 3.121 0 0
Hedgehog 'off' state R-HSA-5610787 8.209074e-04 3.086 0 0
MECP2 regulates transcription factors R-HSA-9022707 8.335544e-04 3.079 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 9.627465e-04 3.016 0 0
Cellular responses to stimuli R-HSA-8953897 9.291573e-04 3.032 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.011882e-03 2.995 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.281441e-03 2.892 0 0
Programmed Cell Death R-HSA-5357801 1.238955e-03 2.907 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.477942e-03 2.830 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.644730e-03 2.784 0 0
Separation of Sister Chromatids R-HSA-2467813 1.680358e-03 2.775 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.817389e-03 2.741 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.935569e-03 2.713 0 0
Signaling by ERBB2 R-HSA-1227986 2.253333e-03 2.647 0 0
Kinesins R-HSA-983189 2.253333e-03 2.647 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.369436e-03 2.625 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.508849e-03 2.601 0 0
Generic Transcription Pathway R-HSA-212436 2.526127e-03 2.598 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.790224e-03 2.554 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.989549e-03 2.524 0 0
Semaphorin interactions R-HSA-373755 2.989549e-03 2.524 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.196745e-03 2.495 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.196745e-03 2.495 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.196745e-03 2.495 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.196745e-03 2.495 0 0
Mitotic Prometaphase R-HSA-68877 3.410763e-03 2.467 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.590482e-03 2.445 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.590482e-03 2.445 0 0
Protein folding R-HSA-391251 3.723526e-03 2.429 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.008678e-03 2.397 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.008678e-03 2.397 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.963242e-03 2.402 0 0
Formation of definitive endoderm R-HSA-9823730 3.963242e-03 2.402 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.020054e-03 2.396 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 4.549457e-03 2.342 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.549457e-03 2.342 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.568196e-03 2.340 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.568196e-03 2.340 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.549457e-03 2.342 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.568196e-03 2.340 0 0
Signaling by LTK R-HSA-9842663 4.510825e-03 2.346 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.170183e-03 2.286 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.272122e-03 2.278 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.856768e-03 2.232 0 0
Integrin signaling R-HSA-354192 5.856768e-03 2.232 0 0
Cardiogenesis R-HSA-9733709 5.856768e-03 2.232 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.856768e-03 2.232 0 0
Gap junction trafficking R-HSA-190828 6.137306e-03 2.212 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.137306e-03 2.212 0 0
Notch-HLH transcription pathway R-HSA-350054 6.328307e-03 2.199 0 0
FOXO-mediated transcription R-HSA-9614085 6.421053e-03 2.192 0 0
Metabolism of non-coding RNA R-HSA-194441 7.032875e-03 2.153 0 0
snRNP Assembly R-HSA-191859 7.032875e-03 2.153 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.592015e-03 2.181 0 0
Nuclear import of Rev protein R-HSA-180746 7.392012e-03 2.131 0 0
Gap junction assembly R-HSA-190861 7.392012e-03 2.131 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.424731e-03 2.129 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.995439e-03 2.097 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.259809e-03 2.083 0 0
HCMV Early Events R-HSA-9609690 8.508433e-03 2.070 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 8.992079e-03 2.046 0 0
RET signaling R-HSA-8853659 9.198422e-03 2.036 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.836572e-03 2.007 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.836572e-03 2.007 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.198422e-03 2.036 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.758573e-03 2.011 0 0
Gap junction trafficking and regulation R-HSA-157858 9.836572e-03 2.007 0 0
EPH-Ephrin signaling R-HSA-2682334 1.035057e-02 1.985 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.197311e-02 1.922 0 0
Regulation of TP53 Expression R-HSA-6804754 1.197311e-02 1.922 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.197311e-02 1.922 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.197311e-02 1.922 0 0
Diseases of cellular response to stress R-HSA-9675132 1.197311e-02 1.922 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.197311e-02 1.922 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.197311e-02 1.922 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.197311e-02 1.922 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.197311e-02 1.922 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.197311e-02 1.922 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.197311e-02 1.922 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.197311e-02 1.922 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.197311e-02 1.922 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.197311e-02 1.922 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.197311e-02 1.922 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.116711e-02 1.952 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.142672e-02 1.942 0 0
Signaling by Hedgehog R-HSA-5358351 1.283952e-02 1.891 0 0
Membrane Trafficking R-HSA-199991 1.187718e-02 1.925 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.233478e-02 1.909 0 0
Metabolism of RNA R-HSA-8953854 1.220986e-02 1.913 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.081175e-02 1.966 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.142672e-02 1.942 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.129992e-02 1.947 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.060034e-02 1.975 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.362472e-02 1.866 0 0
Aggrephagy R-HSA-9646399 1.371958e-02 1.863 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.371958e-02 1.863 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.377677e-02 1.861 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.484011e-02 1.829 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.494884e-02 1.825 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.536124e-02 1.814 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.536124e-02 1.814 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.711847e-02 1.767 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.669082e-02 1.778 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.669082e-02 1.778 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.569619e-02 1.804 0 0
Regulation of CDH11 function R-HSA-9762292 1.681545e-02 1.774 0 0
G2/M Checkpoints R-HSA-69481 1.556119e-02 1.808 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.681545e-02 1.774 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.615860e-02 1.792 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.668765e-02 1.778 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.505562e-02 1.822 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.681545e-02 1.774 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.505562e-02 1.822 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.821428e-02 1.740 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.887195e-02 1.724 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.028642e-02 1.693 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.038852e-02 1.691 0 0
Interleukin-2 signaling R-HSA-9020558 2.038852e-02 1.691 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.065244e-02 1.685 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.170947e-02 1.663 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.185846e-02 1.660 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.553879e-02 1.593 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.553879e-02 1.593 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.553879e-02 1.593 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.553879e-02 1.593 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.553879e-02 1.593 0 0
Signaling by AXIN mutants R-HSA-4839735 2.434600e-02 1.614 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.434600e-02 1.614 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.294782e-02 1.639 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.317284e-02 1.635 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.553879e-02 1.593 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.309982e-02 1.636 0 0
Signaling by NOTCH R-HSA-157118 2.316682e-02 1.635 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.309982e-02 1.636 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.364808e-02 1.626 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.317284e-02 1.635 0 0
Cellular response to heat stress R-HSA-3371556 2.517797e-02 1.599 0 0
Cell junction organization R-HSA-446728 2.315956e-02 1.635 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.546201e-02 1.594 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.294782e-02 1.639 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.499770e-02 1.602 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.586602e-02 1.587 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.586602e-02 1.587 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.586602e-02 1.587 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.699680e-02 1.569 0 0
Transmission across Chemical Synapses R-HSA-112315 2.771591e-02 1.557 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.846014e-02 1.546 1 0
Signaling by PTK6 R-HSA-8848021 2.846014e-02 1.546 1 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.868767e-02 1.542 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.868767e-02 1.542 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.868767e-02 1.542 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.868767e-02 1.542 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.868767e-02 1.542 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.868767e-02 1.542 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.868767e-02 1.542 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.868767e-02 1.542 0 0
Intraflagellar transport R-HSA-5620924 2.909898e-02 1.536 0 0
Formation of axial mesoderm R-HSA-9796292 3.341125e-02 1.476 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.234347e-02 1.490 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.590653e-02 1.445 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.231586e-02 1.491 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.150027e-02 1.502 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.150027e-02 1.502 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.150027e-02 1.502 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.341125e-02 1.476 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.385014e-02 1.470 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.341125e-02 1.476 0 0
IGF1R signaling cascade R-HSA-2428924 3.034682e-02 1.518 0 0
Regulation of TP53 Activity R-HSA-5633007 3.410111e-02 1.467 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.231586e-02 1.491 0 0
HCMV Infection R-HSA-9609646 3.176507e-02 1.498 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 3.385014e-02 1.470 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.385014e-02 1.470 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.392360e-02 1.469 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 3.385014e-02 1.470 0 0
MAPK family signaling cascades R-HSA-5683057 3.104746e-02 1.508 0 0
NrCAM interactions R-HSA-447038 3.385014e-02 1.470 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.296411e-02 1.482 0 0
Signaling by VEGF R-HSA-194138 3.150027e-02 1.502 0 0
DNA Double Strand Break Response R-HSA-5693606 3.650589e-02 1.438 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.774504e-02 1.423 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.872915e-02 1.412 0 0
Long-term potentiation R-HSA-9620244 3.968732e-02 1.401 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 4.003958e-02 1.398 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 4.003958e-02 1.398 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 4.003958e-02 1.398 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 4.003958e-02 1.398 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 4.003958e-02 1.398 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 4.003958e-02 1.398 0 0
Signaling by Interleukins R-HSA-449147 4.006531e-02 1.397 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.103926e-02 1.387 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.136367e-02 1.383 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.170327e-02 1.380 0 0
Adipogenesis R-HSA-9843745 4.214092e-02 1.375 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.220648e-02 1.375 0 0
Signaling by ALK R-HSA-201556 4.220648e-02 1.375 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 4.305782e-02 1.366 0 0
Phosphorylation of Emi1 R-HSA-176417 4.305782e-02 1.366 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.305782e-02 1.366 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.305782e-02 1.366 0 0
Signaling by NTRKs R-HSA-166520 4.328560e-02 1.364 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.343718e-02 1.362 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.343718e-02 1.362 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.368622e-02 1.360 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.398624e-02 1.357 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.398624e-02 1.357 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.307694e-02 1.275 1 1
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.790301e-02 1.320 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.790301e-02 1.320 0 0
Signaling by NOTCH4 R-HSA-9013694 5.392240e-02 1.268 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.846566e-02 1.315 0 0
Signaling by EGFR R-HSA-177929 4.980620e-02 1.303 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.182387e-02 1.285 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.651547e-02 1.332 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.365950e-02 1.270 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.849968e-02 1.314 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.551380e-02 1.342 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.551380e-02 1.342 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 5.307694e-02 1.275 0 0
Signaling by FGFR1 R-HSA-5654736 4.980620e-02 1.303 0 0
Interferon Signaling R-HSA-913531 4.672774e-02 1.330 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.849968e-02 1.314 0 0
Pyroptosis R-HSA-5620971 5.233696e-02 1.281 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.554173e-02 1.255 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.554173e-02 1.255 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.921953e-02 1.308 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.522981e-02 1.345 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.972385e-02 1.303 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.790301e-02 1.320 0 0
Diseases of programmed cell death R-HSA-9645723 4.846566e-02 1.315 0 0
Selective autophagy R-HSA-9663891 4.846566e-02 1.315 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.585722e-02 1.253 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.698678e-02 1.244 0 0
Cell-cell junction organization R-HSA-421270 5.708963e-02 1.243 0 0
MHC class II antigen presentation R-HSA-2132295 5.822422e-02 1.235 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.921551e-02 1.228 0 0
Signaling by FGFR4 R-HSA-5654743 6.024873e-02 1.220 0 0
TBC/RABGAPs R-HSA-8854214 6.024873e-02 1.220 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.171742e-02 1.210 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.256245e-02 1.204 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.256245e-02 1.204 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.256245e-02 1.204 0 0
Signaling by Hippo R-HSA-2028269 6.256245e-02 1.204 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.285768e-02 1.202 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.285768e-02 1.202 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.285768e-02 1.202 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.285768e-02 1.202 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.285768e-02 1.202 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.285768e-02 1.202 0 0
RAB geranylgeranylation R-HSA-8873719 6.285768e-02 1.202 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.382799e-02 1.195 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.382799e-02 1.195 0 0
Cell-Cell communication R-HSA-1500931 6.394223e-02 1.194 0 0
G1 Phase R-HSA-69236 6.430906e-02 1.192 0 0
Cyclin D associated events in G1 R-HSA-69231 6.430906e-02 1.192 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.586454e-02 1.181 0 0
G alpha (12/13) signalling events R-HSA-416482 6.586454e-02 1.181 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.640715e-02 1.178 0 0
Adherens junctions interactions R-HSA-418990 6.845305e-02 1.165 0 0
Signaling by FGFR3 R-HSA-5654741 6.851924e-02 1.164 0 0
Diseases of Telomere Maintenance R-HSA-9673013 7.847832e-02 1.105 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 7.847832e-02 1.105 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 7.847832e-02 1.105 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 7.847832e-02 1.105 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 7.847832e-02 1.105 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 7.847832e-02 1.105 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 7.847832e-02 1.105 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 7.847832e-02 1.105 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 7.847832e-02 1.105 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 7.847832e-02 1.105 0 0
RSK activation R-HSA-444257 7.523647e-02 1.124 0 0
MET receptor recycling R-HSA-8875656 7.523647e-02 1.124 0 0
Activation of RAS in B cells R-HSA-1169092 7.523647e-02 1.124 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 8.723270e-02 1.059 0 0
WNT mediated activation of DVL R-HSA-201688 8.723270e-02 1.059 0 0
ALK mutants bind TKIs R-HSA-9700645 8.723270e-02 1.059 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.198401e-02 1.036 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.221134e-02 1.141 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.586847e-02 1.066 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 9.198401e-02 1.036 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 9.198401e-02 1.036 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.576707e-02 1.121 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.576707e-02 1.121 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.664628e-02 1.116 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.416458e-02 1.075 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.683882e-02 1.061 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.457155e-02 1.127 0 0
Signaling by WNT in cancer R-HSA-4791275 7.221134e-02 1.141 0 0
Inhibition of PKR R-HSA-169131 7.847832e-02 1.105 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 8.723270e-02 1.059 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.339562e-02 1.079 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.928760e-02 1.049 0 0
Protein-protein interactions at synapses R-HSA-6794362 9.031111e-02 1.044 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.198401e-02 1.036 0 0
S Phase R-HSA-69242 8.276813e-02 1.082 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.523647e-02 1.124 0 0
Rap1 signalling R-HSA-392517 7.664628e-02 1.116 0 0
Signal transduction by L1 R-HSA-445144 8.416458e-02 1.075 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 8.723270e-02 1.059 0 0
Apoptotic factor-mediated response R-HSA-111471 6.944160e-02 1.158 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.944160e-02 1.158 0 0
Cardiac conduction R-HSA-5576891 8.343848e-02 1.079 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.523647e-02 1.124 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.203960e-02 1.086 0 0
tRNA processing in the nucleus R-HSA-6784531 7.007131e-02 1.154 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 8.174907e-02 1.088 0 0
Signalling to ERKs R-HSA-187687 9.537395e-02 1.021 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.583400e-02 1.018 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.811941e-02 1.008 0 0
Muscle contraction R-HSA-397014 9.906800e-02 1.004 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.930218e-02 1.003 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.930218e-02 1.003 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 9.975146e-02 1.001 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 9.975146e-02 1.001 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 9.975146e-02 1.001 0 0
Signal attenuation R-HSA-74749 9.975146e-02 1.001 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.000916e-01 1.000 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.000916e-01 1.000 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.000916e-01 1.000 0 0
Neuronal System R-HSA-112316 1.079282e-01 0.967 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.081306e-01 0.966 0 0
HIV Life Cycle R-HSA-162587 1.083960e-01 0.965 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.084741e-01 0.965 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.096603e-01 0.960 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.096603e-01 0.960 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.127318e-01 0.948 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.127318e-01 0.948 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.127318e-01 0.948 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.127318e-01 0.948 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.127318e-01 0.948 0 0
Formation of the posterior neural plate R-HSA-9832991 1.127318e-01 0.948 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.127318e-01 0.948 0 0
Signaling by APC mutants R-HSA-4839744 1.127318e-01 0.948 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.132425e-01 0.946 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.153801e-01 0.938 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.153801e-01 0.938 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.153801e-01 0.938 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.153801e-01 0.938 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.153801e-01 0.938 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.153801e-01 0.938 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 1.153801e-01 0.938 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 1.153801e-01 0.938 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.153801e-01 0.938 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.153801e-01 0.938 0 0
Signaling by NOTCH3 R-HSA-9012852 1.185775e-01 0.926 0 0
Gene Silencing by RNA R-HSA-211000 1.186352e-01 0.926 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 1.508064e-01 0.822 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 1.508064e-01 0.822 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 1.508064e-01 0.822 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 1.848160e-01 0.733 0 0
MET activates PTPN11 R-HSA-8865999 1.848160e-01 0.733 0 0
Classical Kir channels R-HSA-1296053 1.848160e-01 0.733 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.848160e-01 0.733 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.848160e-01 0.733 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.174656e-01 0.663 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.174656e-01 0.663 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.174656e-01 0.663 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.174656e-01 0.663 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.174656e-01 0.663 0 0
Activation of AMPA receptors R-HSA-399710 2.488094e-01 0.604 0 0
IRS activation R-HSA-74713 2.488094e-01 0.604 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.488094e-01 0.604 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 2.488094e-01 0.604 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.261170e-01 0.899 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.261170e-01 0.899 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.261170e-01 0.899 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.398537e-01 0.854 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.788996e-01 0.555 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.788996e-01 0.555 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.788996e-01 0.555 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.538925e-01 0.813 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.538925e-01 0.813 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.538925e-01 0.813 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.681874e-01 0.774 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.077862e-01 0.512 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.077862e-01 0.512 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.826953e-01 0.738 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.826953e-01 0.738 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.826953e-01 0.738 0 0
Deadenylation of mRNA R-HSA-429947 1.260090e-01 0.900 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.973765e-01 0.705 0 0
Phase 4 - resting membrane potential R-HSA-5576886 1.973765e-01 0.705 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.355173e-01 0.474 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.355173e-01 0.474 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.355173e-01 0.474 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.355173e-01 0.474 0 0
SOS-mediated signalling R-HSA-112412 3.355173e-01 0.474 0 0
Recycling of eIF2:GDP R-HSA-72731 3.355173e-01 0.474 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.355173e-01 0.474 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.355173e-01 0.474 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.121938e-01 0.673 0 0
GAB1 signalosome R-HSA-180292 2.421018e-01 0.616 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.285524e-01 0.891 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 2.571313e-01 0.590 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.571313e-01 0.590 0 0
Trafficking of AMPA receptors R-HSA-399719 1.940025e-01 0.712 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.721740e-01 0.565 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.721740e-01 0.565 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.721740e-01 0.565 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.721740e-01 0.565 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.721740e-01 0.565 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.721740e-01 0.565 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.043722e-01 0.690 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.148657e-01 0.668 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 2.872047e-01 0.542 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.736750e-01 0.760 0 0
Nucleosome assembly R-HSA-774815 1.736750e-01 0.760 0 0
Striated Muscle Contraction R-HSA-390522 2.254701e-01 0.647 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.816731e-01 0.741 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.816731e-01 0.741 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.816731e-01 0.741 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.816731e-01 0.741 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 3.022005e-01 0.520 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.171400e-01 0.499 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.578241e-01 0.589 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.147930e-01 0.668 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.320037e-01 0.479 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.687493e-01 0.571 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.319373e-01 0.635 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.467738e-01 0.460 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.406327e-01 0.619 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.406327e-01 0.619 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.907422e-01 0.536 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.614338e-01 0.442 0 0
HDACs deacetylate histones R-HSA-3214815 2.582374e-01 0.588 0 0
MAP2K and MAPK activation R-HSA-5674135 3.239294e-01 0.490 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.239294e-01 0.490 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.850844e-01 0.545 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 2.632385e-01 0.580 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.444778e-01 0.840 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.639690e-01 0.785 0 0
Co-inhibition by PD-1 R-HSA-389948 2.871009e-01 0.542 0 0
DAP12 signaling R-HSA-2424491 1.837697e-01 0.736 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.872047e-01 0.542 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.400463e-01 0.468 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.604436e-01 0.795 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.421018e-01 0.616 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.355173e-01 0.474 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.239294e-01 0.490 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.121938e-01 0.673 0 0
Meiosis R-HSA-1500620 3.320746e-01 0.479 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.797256e-01 0.553 0 0
Insulin receptor signalling cascade R-HSA-74751 3.397602e-01 0.469 0 0
Myogenesis R-HSA-525793 1.444778e-01 0.840 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.687493e-01 0.571 0 0
Signaling by RAS mutants R-HSA-6802949 1.816731e-01 0.741 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.897905e-01 0.722 0 0
Homology Directed Repair R-HSA-5693538 1.768018e-01 0.753 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.260090e-01 0.900 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.421018e-01 0.616 0 0
COPII-mediated vesicle transport R-HSA-204005 2.167662e-01 0.664 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.017884e-01 0.520 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.089486e-01 0.680 0 0
Developmental Cell Lineages R-HSA-9734767 1.882257e-01 0.725 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.593487e-01 0.586 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.383559e-01 0.471 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.383559e-01 0.471 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.467738e-01 0.460 0 0
RNA Polymerase I Transcription R-HSA-73864 2.769783e-01 0.558 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.615785e-01 0.582 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.436138e-01 0.613 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.488094e-01 0.604 0 0
Activation of AKT2 R-HSA-165158 2.488094e-01 0.604 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.837697e-01 0.736 0 0
Defective pyroptosis R-HSA-9710421 1.580627e-01 0.801 0 0
RAF activation R-HSA-5673000 2.361727e-01 0.627 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.023980e-01 0.694 0 0
Tight junction interactions R-HSA-420029 3.614338e-01 0.442 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.128541e-01 0.505 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.350050e-01 0.475 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.123115e-01 0.505 0 0
Ephrin signaling R-HSA-3928664 2.421018e-01 0.616 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 3.320037e-01 0.479 0 0
HSF1-dependent transactivation R-HSA-3371571 2.233219e-01 0.651 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.314404e-01 0.636 0 0
Regulation of CDH1 Function R-HSA-9764561 2.760851e-01 0.559 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.488094e-01 0.604 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.788996e-01 0.555 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.681874e-01 0.774 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 1.826953e-01 0.738 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.271128e-01 0.644 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.797256e-01 0.553 0 0
Mismatch Repair R-HSA-5358508 2.421018e-01 0.616 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.314404e-01 0.636 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.837697e-01 0.736 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.254701e-01 0.647 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.469614e-01 0.607 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.167662e-01 0.664 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.320578e-01 0.634 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.398537e-01 0.854 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.271128e-01 0.644 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.571313e-01 0.590 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.148657e-01 0.668 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.685547e-01 0.571 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.736750e-01 0.760 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.736750e-01 0.760 0 0
Signaling by FGFR2 R-HSA-5654738 1.547811e-01 0.810 0 0
Stabilization of p53 R-HSA-69541 1.215679e-01 0.915 0 0
Specification of the neural plate border R-HSA-9834899 2.571313e-01 0.590 0 0
Signaling by WNT R-HSA-195721 3.232342e-01 0.490 0 0
Hedgehog 'on' state R-HSA-5632684 2.240670e-01 0.650 0 0
Dopamine receptors R-HSA-390651 2.174656e-01 0.663 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.488094e-01 0.604 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.261170e-01 0.899 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.788996e-01 0.555 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 3.077862e-01 0.512 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.077862e-01 0.512 0 0
Netrin mediated repulsion signals R-HSA-418886 3.355173e-01 0.474 0 0
Disinhibition of SNARE formation R-HSA-114516 3.355173e-01 0.474 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.637685e-01 0.786 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.254701e-01 0.647 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.022005e-01 0.520 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.578241e-01 0.589 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.579505e-01 0.588 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.324537e-01 0.478 0 0
DAP12 interactions R-HSA-2172127 3.571208e-01 0.447 0 0
Cilium Assembly R-HSA-5617833 1.533927e-01 0.814 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.736872e-01 0.760 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.837697e-01 0.736 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 2.469614e-01 0.607 0 0
Frs2-mediated activation R-HSA-170968 1.538925e-01 0.813 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.469614e-01 0.607 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.629483e-01 0.788 0 0
Gastrulation R-HSA-9758941 2.474803e-01 0.606 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.540274e-01 0.812 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.986258e-01 0.702 0 0
Prolonged ERK activation events R-HSA-169893 1.973765e-01 0.705 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.351337e-01 0.869 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.940025e-01 0.712 0 0
Cargo concentration in the ER R-HSA-5694530 1.940025e-01 0.712 0 0
Interleukin-2 family signaling R-HSA-451927 3.017884e-01 0.520 0 0
Vesicle-mediated transport R-HSA-5653656 1.228085e-01 0.911 0 0
Signaling by FGFR R-HSA-190236 1.624320e-01 0.789 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.174656e-01 0.663 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.355173e-01 0.474 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.355173e-01 0.474 0 0
Heme signaling R-HSA-9707616 1.614433e-01 0.792 0 0
GPER1 signaling R-HSA-9634597 1.980207e-01 0.703 0 0
Degradation of CDH1 R-HSA-9766229 2.063570e-01 0.685 0 0
HIV Infection R-HSA-162906 3.130279e-01 0.504 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.022005e-01 0.520 0 0
Signaling by NOTCH1 R-HSA-1980143 1.330567e-01 0.876 0 0
G1/S Transition R-HSA-69206 2.178102e-01 0.662 0 0
mTORC1-mediated signalling R-HSA-166208 3.171400e-01 0.499 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.614338e-01 0.442 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.004018e-01 0.522 0 0
Adaptive Immune System R-HSA-1280218 2.658331e-01 0.575 0 0
ER-Phagosome pathway R-HSA-1236974 2.150922e-01 0.667 0 0
Platelet degranulation R-HSA-114608 3.618511e-01 0.441 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.676882e-01 0.572 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.549709e-01 0.810 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.848160e-01 0.733 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.488094e-01 0.604 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.077862e-01 0.512 0 0
Abacavir transmembrane transport R-HSA-2161517 3.077862e-01 0.512 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.355173e-01 0.474 0 0
Disorders of Developmental Biology R-HSA-9675151 2.121938e-01 0.673 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.421018e-01 0.616 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.467738e-01 0.460 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.360660e-01 0.866 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.547811e-01 0.810 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.232479e-01 0.651 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.099414e-01 0.509 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.788996e-01 0.555 0 0
Signaling by ROBO receptors R-HSA-376176 2.026446e-01 0.693 0 0
Ion homeostasis R-HSA-5578775 1.243363e-01 0.905 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.350050e-01 0.475 0 0
Histamine receptors R-HSA-390650 1.848160e-01 0.733 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.077862e-01 0.512 0 0
NRAGE signals death through JNK R-HSA-193648 1.243363e-01 0.905 0 0
ERK/MAPK targets R-HSA-198753 2.872047e-01 0.542 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.792988e-01 0.554 0 0
PLC beta mediated events R-HSA-112043 3.123115e-01 0.505 0 0
ESR-mediated signaling R-HSA-8939211 3.609766e-01 0.443 0 0
Formation of the anterior neural plate R-HSA-9823739 1.826953e-01 0.738 0 0
Rab regulation of trafficking R-HSA-9007101 1.719339e-01 0.765 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.848160e-01 0.733 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.174656e-01 0.663 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.488094e-01 0.604 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.488094e-01 0.604 0 0
Activation of RAC1 R-HSA-428540 1.261170e-01 0.899 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.788996e-01 0.555 0 0
CREB phosphorylation R-HSA-199920 3.077862e-01 0.512 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.077862e-01 0.512 0 0
Negative regulation of FLT3 R-HSA-9706369 1.973765e-01 0.705 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.355173e-01 0.474 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.540274e-01 0.812 0 0
Chromatin modifying enzymes R-HSA-3247509 3.464517e-01 0.460 0 0
Immune System R-HSA-168256 1.430650e-01 0.844 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.900336e-01 0.721 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.032035e-01 0.518 0 0
Chromatin organization R-HSA-4839726 3.094784e-01 0.509 0 0
Netrin-1 signaling R-HSA-373752 1.658027e-01 0.780 0 0
HDMs demethylate histones R-HSA-3214842 3.614338e-01 0.442 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.837697e-01 0.736 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.398537e-01 0.854 0 0
Ca-dependent events R-HSA-111996 3.350050e-01 0.475 0 0
Autophagy R-HSA-9612973 2.847133e-01 0.546 0 0
Hemostasis R-HSA-109582 2.543671e-01 0.595 0 0
RUNX2 regulates bone development R-HSA-8941326 2.578241e-01 0.589 0 0
Diseases of Immune System R-HSA-5260271 1.285524e-01 0.891 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 1.285524e-01 0.891 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.148657e-01 0.668 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.687493e-01 0.571 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 3.239294e-01 0.490 0 0
PTEN Regulation R-HSA-6807070 1.928182e-01 0.715 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.423005e-01 0.616 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 2.788996e-01 0.555 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 2.788996e-01 0.555 0 0
CHL1 interactions R-HSA-447041 3.355173e-01 0.474 0 0
Synthesis of PG R-HSA-1483148 2.121938e-01 0.673 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.171400e-01 0.499 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.614338e-01 0.442 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.614338e-01 0.442 0 0
Intra-Golgi traffic R-HSA-6811438 3.239294e-01 0.490 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.312208e-01 0.480 0 0
Amine ligand-binding receptors R-HSA-375280 3.571208e-01 0.447 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.198736e-01 0.658 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.120734e-01 0.674 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.826953e-01 0.738 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.128541e-01 0.505 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.167662e-01 0.664 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.671340e-01 0.573 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.973765e-01 0.705 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.320037e-01 0.479 0 0
Host Interactions of HIV factors R-HSA-162909 2.072326e-01 0.684 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.540274e-01 0.812 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.571313e-01 0.590 0 0
Macroautophagy R-HSA-1632852 2.023502e-01 0.694 0 0
Inositol phosphate metabolism R-HSA-1483249 1.396476e-01 0.855 0 0
Sensory processing of sound R-HSA-9659379 2.847469e-01 0.546 0 0
Influenza Infection R-HSA-168255 1.920123e-01 0.717 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.214440e-01 0.493 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.538925e-01 0.813 0 0
Toll-like Receptor Cascades R-HSA-168898 3.572088e-01 0.447 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.788996e-01 0.555 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.121938e-01 0.673 0 0
Tie2 Signaling R-HSA-210993 2.421018e-01 0.616 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.023980e-01 0.694 0 0
Neurodegenerative Diseases R-HSA-8863678 3.467738e-01 0.460 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.467738e-01 0.460 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.243363e-01 0.905 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.388822e-01 0.622 0 0
Disorders of transmembrane transporters R-HSA-5619115 3.005163e-01 0.522 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.889079e-01 0.539 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.889079e-01 0.539 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.889079e-01 0.539 0 0
Specification of primordial germ cells R-HSA-9827857 2.271128e-01 0.644 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 1.538925e-01 0.813 0 0
SLC transporter disorders R-HSA-5619102 1.416795e-01 0.849 0 0
FLT3 Signaling R-HSA-9607240 3.128541e-01 0.505 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 2.271128e-01 0.644 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.421018e-01 0.616 0 0
Glycolysis R-HSA-70171 3.028993e-01 0.519 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.467738e-01 0.460 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 1.681874e-01 0.774 0 0
Signaling by SCF-KIT R-HSA-1433557 3.460717e-01 0.461 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 2.571313e-01 0.590 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.961903e-01 0.707 0 0
IRE1alpha activates chaperones R-HSA-381070 2.345865e-01 0.630 0 0
Interleukin-12 signaling R-HSA-9020591 1.330567e-01 0.876 0 0
Interleukin-12 family signaling R-HSA-447115 2.024207e-01 0.694 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.621391e-01 0.441 0 0
phospho-PLA2 pathway R-HSA-111995 3.621391e-01 0.441 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.621391e-01 0.441 0 0
Formation of annular gap junctions R-HSA-196025 3.621391e-01 0.441 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.621391e-01 0.441 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.621391e-01 0.441 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.621391e-01 0.441 0 0
FGFR1b ligand binding and activation R-HSA-190370 3.621391e-01 0.441 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.621391e-01 0.441 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.621391e-01 0.441 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.621391e-01 0.441 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.621391e-01 0.441 0 0
Adrenoceptors R-HSA-390696 3.621391e-01 0.441 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.670362e-01 0.435 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.670362e-01 0.435 0 0
G-protein mediated events R-HSA-112040 3.672817e-01 0.435 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.742284e-01 0.427 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.759691e-01 0.425 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.759691e-01 0.425 0 0
TRP channels R-HSA-3295583 3.759691e-01 0.425 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.759691e-01 0.425 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.759691e-01 0.425 0 0
Regulated Necrosis R-HSA-5218859 3.764475e-01 0.424 0 0
G alpha (q) signalling events R-HSA-416476 3.785310e-01 0.422 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.791336e-01 0.421 0 0
Signaling by TGFBR3 R-HSA-9839373 3.791336e-01 0.421 0 0
Diseases of DNA repair R-HSA-9675135 3.791336e-01 0.421 0 0
DNA Repair R-HSA-73894 3.867079e-01 0.413 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.876959e-01 0.412 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.876959e-01 0.412 0 0
Lipophagy R-HSA-9613354 3.876959e-01 0.412 0 0
Gap junction degradation R-HSA-190873 3.876959e-01 0.412 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.876959e-01 0.412 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.876959e-01 0.412 0 0
ARMS-mediated activation R-HSA-170984 3.876959e-01 0.412 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.876959e-01 0.412 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.876959e-01 0.412 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 3.876959e-01 0.412 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.876959e-01 0.412 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.876959e-01 0.412 0 0
Reproduction R-HSA-1474165 3.881851e-01 0.411 0 0
Synthesis of PC R-HSA-1483191 3.900817e-01 0.409 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 3.903659e-01 0.409 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.903659e-01 0.409 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 3.903659e-01 0.409 0 0
Triglyceride biosynthesis R-HSA-75109 3.903659e-01 0.409 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.947378e-01 0.404 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.958178e-01 0.403 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.958178e-01 0.403 0 0
Co-stimulation by CD28 R-HSA-389356 4.009812e-01 0.397 0 0
Circadian clock R-HSA-9909396 4.013716e-01 0.396 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.030105e-01 0.395 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.038531e-01 0.394 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.038531e-01 0.394 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.038531e-01 0.394 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.046123e-01 0.393 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.046123e-01 0.393 0 0
Pyrimidine salvage R-HSA-73614 4.046123e-01 0.393 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.101974e-01 0.387 0 0
PPARA activates gene expression R-HSA-1989781 4.116380e-01 0.385 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.122302e-01 0.385 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.122302e-01 0.385 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.122302e-01 0.385 0 0
PI3K/AKT activation R-HSA-198203 4.122302e-01 0.385 0 0
Binding and entry of HIV virion R-HSA-173107 4.122302e-01 0.385 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.122302e-01 0.385 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.122302e-01 0.385 0 0
2-LTR circle formation R-HSA-164843 4.122302e-01 0.385 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.122302e-01 0.385 0 0
Signaling by Leptin R-HSA-2586552 4.122302e-01 0.385 0 0
DNA methylation R-HSA-5334118 4.186970e-01 0.378 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.186970e-01 0.378 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.186970e-01 0.378 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.186970e-01 0.378 0 0
Signaling by Erythropoietin R-HSA-9006335 4.186970e-01 0.378 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.186970e-01 0.378 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.186970e-01 0.378 0 0
PI3K Cascade R-HSA-109704 4.226074e-01 0.374 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 4.238714e-01 0.373 0 0
HCMV Late Events R-HSA-9610379 4.238714e-01 0.373 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.245448e-01 0.372 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.299814e-01 0.367 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.326103e-01 0.364 0 0
Interleukin-37 signaling R-HSA-9008059 4.326103e-01 0.364 0 0
Meiotic recombination R-HSA-912446 4.333213e-01 0.363 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.357829e-01 0.361 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 4.357829e-01 0.361 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.357829e-01 0.361 0 0
Bicarbonate transporters R-HSA-425381 4.357829e-01 0.361 0 0
Suppression of apoptosis R-HSA-9635465 4.357829e-01 0.361 0 0
Prostanoid ligand receptors R-HSA-391908 4.357829e-01 0.361 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.357829e-01 0.361 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.399947e-01 0.357 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.437231e-01 0.353 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.439614e-01 0.353 0 0
Neurexins and neuroligins R-HSA-6794361 4.439614e-01 0.353 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.439614e-01 0.353 0 0
Mitochondrial biogenesis R-HSA-1592230 4.459665e-01 0.351 0 0
Glucose metabolism R-HSA-70326 4.459665e-01 0.351 0 0
EGFR downregulation R-HSA-182971 4.463432e-01 0.350 0 0
Downstream signal transduction R-HSA-186763 4.463432e-01 0.350 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.539074e-01 0.343 0 0
Meiotic synapsis R-HSA-1221632 4.545220e-01 0.342 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.545220e-01 0.342 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.545220e-01 0.342 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.545220e-01 0.342 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.583932e-01 0.339 0 0
Integration of provirus R-HSA-162592 4.583932e-01 0.339 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.583932e-01 0.339 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.583932e-01 0.339 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.583932e-01 0.339 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.583932e-01 0.339 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.583932e-01 0.339 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.583932e-01 0.339 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.583932e-01 0.339 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.583932e-01 0.339 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.583932e-01 0.339 0 0
Disease R-HSA-1643685 4.598853e-01 0.337 0 0
G0 and Early G1 R-HSA-1538133 4.598879e-01 0.337 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.604224e-01 0.337 0 0
Parasite infection R-HSA-9664407 4.604224e-01 0.337 0 0
Leishmania phagocytosis R-HSA-9664417 4.604224e-01 0.337 0 0
Translation initiation complex formation R-HSA-72649 4.649980e-01 0.333 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.649980e-01 0.333 0 0
PCP/CE pathway R-HSA-4086400 4.667092e-01 0.331 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.669204e-01 0.331 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.672338e-01 0.330 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.732374e-01 0.325 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.732374e-01 0.325 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.732374e-01 0.325 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.732374e-01 0.325 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.732374e-01 0.325 0 0
Nuclear RNA decay R-HSA-9930044 4.732374e-01 0.325 0 0
G-protein beta:gamma signalling R-HSA-397795 4.732374e-01 0.325 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.732374e-01 0.325 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.742557e-01 0.324 0 0
Chromosome Maintenance R-HSA-73886 4.742557e-01 0.324 0 0
ABC-family proteins mediated transport R-HSA-382556 4.750045e-01 0.323 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.800987e-01 0.319 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.800987e-01 0.319 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.800987e-01 0.319 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.800987e-01 0.319 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.800987e-01 0.319 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.800987e-01 0.319 0 0
MET activates RAS signaling R-HSA-8851805 4.800987e-01 0.319 0 0
Interleukin-15 signaling R-HSA-8983432 4.800987e-01 0.319 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.800987e-01 0.319 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.800987e-01 0.319 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.800987e-01 0.319 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.800987e-01 0.319 0 0
Pervasive developmental disorders R-HSA-9005895 4.800987e-01 0.319 0 0
Disorders of Nervous System Development R-HSA-9697154 4.800987e-01 0.319 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 4.800987e-01 0.319 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 4.800987e-01 0.319 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.800987e-01 0.319 0 0
OAS antiviral response R-HSA-8983711 4.800987e-01 0.319 0 0
Signaling by MET R-HSA-6806834 4.842493e-01 0.315 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 4.849639e-01 0.314 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.856772e-01 0.314 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.856772e-01 0.314 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.856772e-01 0.314 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.862975e-01 0.313 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.863857e-01 0.313 0 0
Miscellaneous transport and binding events R-HSA-5223345 4.863857e-01 0.313 0 0
Neutrophil degranulation R-HSA-6798695 4.884766e-01 0.311 0 0
IRS-mediated signalling R-HSA-112399 4.958716e-01 0.305 0 0
Synthesis of PA R-HSA-1483166 4.958716e-01 0.305 0 0
Signaling by NOTCH2 R-HSA-1980145 4.993273e-01 0.302 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.993273e-01 0.302 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.993273e-01 0.302 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.993273e-01 0.302 0 0
Signal amplification R-HSA-392518 4.993273e-01 0.302 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.993273e-01 0.302 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.993273e-01 0.302 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.993273e-01 0.302 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.009356e-01 0.300 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.009356e-01 0.300 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.009356e-01 0.300 0 0
FGFR1c ligand binding and activation R-HSA-190373 5.009356e-01 0.300 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.009356e-01 0.300 0 0
Maturation of nucleoprotein R-HSA-9683610 5.009356e-01 0.300 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 5.009356e-01 0.300 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.015545e-01 0.300 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.059639e-01 0.296 0 0
tRNA processing R-HSA-72306 5.083540e-01 0.294 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 5.120579e-01 0.291 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.120579e-01 0.291 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.159504e-01 0.287 0 0
Regulation of beta-cell development R-HSA-186712 5.159504e-01 0.287 0 0
Viral Infection Pathways R-HSA-9824446 5.161057e-01 0.287 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.186019e-01 0.285 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.186019e-01 0.285 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.207695e-01 0.283 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.209386e-01 0.283 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.209386e-01 0.283 0 0
Hydrolysis of LPC R-HSA-1483115 5.209386e-01 0.283 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.209386e-01 0.283 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.209386e-01 0.283 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.209386e-01 0.283 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.209386e-01 0.283 0 0
Regulation of KIT signaling R-HSA-1433559 5.209386e-01 0.283 0 0
Acyl chain remodeling of CL R-HSA-1482798 5.209386e-01 0.283 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.245734e-01 0.280 0 0
GPVI-mediated activation cascade R-HSA-114604 5.245734e-01 0.280 0 0
Calmodulin induced events R-HSA-111933 5.245734e-01 0.280 0 0
CaM pathway R-HSA-111997 5.245734e-01 0.280 0 0
G1/S-Specific Transcription R-HSA-69205 5.245734e-01 0.280 0 0
FLT3 signaling in disease R-HSA-9682385 5.245734e-01 0.280 0 0
Ub-specific processing proteases R-HSA-5689880 5.259934e-01 0.279 0 0
Potential therapeutics for SARS R-HSA-9679191 5.306453e-01 0.275 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.355927e-01 0.271 0 0
Nucleotide salvage R-HSA-8956321 5.355927e-01 0.271 0 0
MAP kinase activation R-HSA-450294 5.355927e-01 0.271 0 0
Degradation of AXIN R-HSA-4641257 5.368708e-01 0.270 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 5.368708e-01 0.270 0 0
Degradation of DVL R-HSA-4641258 5.368708e-01 0.270 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.368708e-01 0.270 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.401410e-01 0.267 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 5.401410e-01 0.267 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.401410e-01 0.267 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.401410e-01 0.267 0 0
Erythropoietin activates RAS R-HSA-9027284 5.401410e-01 0.267 0 0
Translesion synthesis by REV1 R-HSA-110312 5.401410e-01 0.267 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.401410e-01 0.267 0 0
Transport and metabolism of PAPS R-HSA-174362 5.401410e-01 0.267 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 5.401410e-01 0.267 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.401410e-01 0.267 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.401410e-01 0.267 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.401410e-01 0.267 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.401410e-01 0.267 0 0
Protein methylation R-HSA-8876725 5.401410e-01 0.267 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.430064e-01 0.265 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.430064e-01 0.265 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.430464e-01 0.265 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.452426e-01 0.263 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 5.546834e-01 0.256 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.547746e-01 0.256 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.575581e-01 0.254 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.575581e-01 0.254 0 0
Translesion synthesis by POLI R-HSA-5656121 5.585749e-01 0.253 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.585749e-01 0.253 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.585749e-01 0.253 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 5.585749e-01 0.253 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.585749e-01 0.253 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.585749e-01 0.253 0 0
Killing mechanisms R-HSA-9664420 5.585749e-01 0.253 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 5.585749e-01 0.253 0 0
Phosphorylation of the APC/C R-HSA-176412 5.585749e-01 0.253 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.585749e-01 0.253 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.585749e-01 0.253 0 0
Activation of SMO R-HSA-5635838 5.585749e-01 0.253 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.585749e-01 0.253 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.585749e-01 0.253 0 0
Atorvastatin ADME R-HSA-9754706 5.585749e-01 0.253 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.608010e-01 0.251 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.608010e-01 0.251 0 0
Ion transport by P-type ATPases R-HSA-936837 5.641865e-01 0.249 0 0
Deubiquitination R-HSA-5688426 5.693280e-01 0.245 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.724303e-01 0.242 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.724303e-01 0.242 0 0
Attenuation phase R-HSA-3371568 5.724303e-01 0.242 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.724303e-01 0.242 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.724303e-01 0.242 0 0
HIV Transcription Elongation R-HSA-167169 5.724303e-01 0.242 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.724303e-01 0.242 0 0
Cellular response to hypoxia R-HSA-1234174 5.734762e-01 0.241 0 0
SARS-CoV Infections R-HSA-9679506 5.738624e-01 0.241 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.762709e-01 0.239 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.762709e-01 0.239 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.762709e-01 0.239 0 0
Translesion synthesis by POLK R-HSA-5655862 5.762709e-01 0.239 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.762709e-01 0.239 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.762709e-01 0.239 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.762709e-01 0.239 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 5.762709e-01 0.239 0 0
Scavenging by Class B Receptors R-HSA-3000471 5.762709e-01 0.239 0 0
Passive transport by Aquaporins R-HSA-432047 5.762709e-01 0.239 0 0
Fibronectin matrix formation R-HSA-1566977 5.762709e-01 0.239 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.826415e-01 0.235 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.838341e-01 0.234 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.838341e-01 0.234 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.838341e-01 0.234 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.838341e-01 0.234 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.916810e-01 0.228 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.932586e-01 0.227 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.932586e-01 0.227 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.932586e-01 0.227 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.932586e-01 0.227 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 5.932586e-01 0.227 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.932586e-01 0.227 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.932586e-01 0.227 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.948011e-01 0.226 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 5.950118e-01 0.225 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.950118e-01 0.225 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.950118e-01 0.225 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.950118e-01 0.225 0 0
Signaling by Insulin receptor R-HSA-74752 5.993228e-01 0.222 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.010702e-01 0.221 0 0
Activation of GABAB receptors R-HSA-991365 6.059633e-01 0.218 0 0
GABA B receptor activation R-HSA-977444 6.059633e-01 0.218 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.059633e-01 0.218 0 0
MTOR signalling R-HSA-165159 6.059633e-01 0.218 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.069370e-01 0.217 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.095661e-01 0.215 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.095661e-01 0.215 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.095661e-01 0.215 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.095661e-01 0.215 0 0
PKA activation in glucagon signalling R-HSA-164378 6.095661e-01 0.215 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.095661e-01 0.215 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.095661e-01 0.215 0 0
PKA activation R-HSA-163615 6.095661e-01 0.215 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.095661e-01 0.215 0 0
Platelet sensitization by LDL R-HSA-432142 6.095661e-01 0.215 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.133274e-01 0.212 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.133274e-01 0.212 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.144624e-01 0.212 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.166886e-01 0.210 0 0
Interleukin-17 signaling R-HSA-448424 6.180297e-01 0.209 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.218977e-01 0.206 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.252209e-01 0.204 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.252209e-01 0.204 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.252209e-01 0.204 0 0
Regulation of signaling by CBL R-HSA-912631 6.252209e-01 0.204 0 0
Maturation of nucleoprotein R-HSA-9694631 6.252209e-01 0.204 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.252209e-01 0.204 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.252209e-01 0.204 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 6.252209e-01 0.204 0 0
Other interleukin signaling R-HSA-449836 6.252209e-01 0.204 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.265523e-01 0.203 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.271884e-01 0.203 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.271884e-01 0.203 0 0
Cellular response to chemical stress R-HSA-9711123 6.297522e-01 0.201 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.349433e-01 0.197 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.349433e-01 0.197 0 0
Phospholipid metabolism R-HSA-1483257 6.355847e-01 0.197 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 6.374634e-01 0.196 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.374634e-01 0.196 0 0
Somitogenesis R-HSA-9824272 6.374634e-01 0.196 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.374634e-01 0.196 0 0
DAG and IP3 signaling R-HSA-1489509 6.374634e-01 0.196 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.402488e-01 0.194 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.402488e-01 0.194 0 0
Negative regulation of MET activity R-HSA-6807004 6.402488e-01 0.194 0 0
Acyl chain remodelling of PI R-HSA-1482922 6.402488e-01 0.194 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.402488e-01 0.194 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.402488e-01 0.194 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.475148e-01 0.189 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.507215e-01 0.187 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 6.513284e-01 0.186 0 0
Signaling by ERBB4 R-HSA-1236394 6.513284e-01 0.186 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.529534e-01 0.185 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.546750e-01 0.184 0 0
G-protein activation R-HSA-202040 6.546750e-01 0.184 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.546750e-01 0.184 0 0
Signalling to RAS R-HSA-167044 6.546750e-01 0.184 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.546750e-01 0.184 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.546750e-01 0.184 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.546750e-01 0.184 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 6.546750e-01 0.184 0 0
Acyl chain remodelling of PG R-HSA-1482925 6.546750e-01 0.184 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.546750e-01 0.184 0 0
Lagging Strand Synthesis R-HSA-69186 6.546750e-01 0.184 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 6.573440e-01 0.182 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.573440e-01 0.182 0 0
HATs acetylate histones R-HSA-3214847 6.576944e-01 0.182 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.585955e-01 0.181 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.593217e-01 0.181 0 0
Protein ubiquitination R-HSA-8852135 6.593217e-01 0.181 0 0
Formation of the cornified envelope R-HSA-6809371 6.647761e-01 0.177 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.685236e-01 0.175 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.685236e-01 0.175 0 0
Glutathione synthesis and recycling R-HSA-174403 6.685236e-01 0.175 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.685236e-01 0.175 0 0
Interleukin-1 signaling R-HSA-9020702 6.713569e-01 0.173 0 0
PI Metabolism R-HSA-1483255 6.780457e-01 0.169 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.818176e-01 0.166 0 0
FGFR2 alternative splicing R-HSA-6803529 6.818176e-01 0.166 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.818176e-01 0.166 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.818176e-01 0.166 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.818176e-01 0.166 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.818176e-01 0.166 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.818176e-01 0.166 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 6.818176e-01 0.166 0 0
LDL clearance R-HSA-8964038 6.818176e-01 0.166 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 6.818176e-01 0.166 0 0
Integrin cell surface interactions R-HSA-216083 6.825032e-01 0.166 0 0
Azathioprine ADME R-HSA-9748787 6.855159e-01 0.164 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 6.860513e-01 0.164 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.895982e-01 0.161 0 0
Opioid Signalling R-HSA-111885 6.911372e-01 0.160 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.911372e-01 0.160 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.911372e-01 0.160 0 0
Interleukin-1 family signaling R-HSA-446652 6.937506e-01 0.159 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.944750e-01 0.158 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.944750e-01 0.158 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.945792e-01 0.158 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.945792e-01 0.158 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.945792e-01 0.158 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.945792e-01 0.158 0 0
Biosynthesis of maresins R-HSA-9018682 6.945792e-01 0.158 0 0
Syndecan interactions R-HSA-3000170 6.945792e-01 0.158 0 0
Growth hormone receptor signaling R-HSA-982772 6.945792e-01 0.158 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.972935e-01 0.157 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.032221e-01 0.153 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.032221e-01 0.153 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.032221e-01 0.153 0 0
Nucleotide Excision Repair R-HSA-5696398 7.038465e-01 0.153 0 0
Death Receptor Signaling R-HSA-73887 7.042658e-01 0.152 0 0
Amyloid fiber formation R-HSA-977225 7.044905e-01 0.152 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.059713e-01 0.151 0 0
CYP2E1 reactions R-HSA-211999 7.068298e-01 0.151 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.068298e-01 0.151 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.068298e-01 0.151 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.068298e-01 0.151 0 0
Complex III assembly R-HSA-9865881 7.068298e-01 0.151 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.068298e-01 0.151 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.117599e-01 0.148 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.117599e-01 0.148 0 0
Smooth Muscle Contraction R-HSA-445355 7.117599e-01 0.148 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.185896e-01 0.144 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.185896e-01 0.144 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.185896e-01 0.144 0 0
G protein gated Potassium channels R-HSA-1296059 7.185896e-01 0.144 0 0
TGFBR3 expression R-HSA-9839394 7.185896e-01 0.144 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.185896e-01 0.144 0 0
Formation of the nephric duct R-HSA-9830364 7.185896e-01 0.144 0 0
Interleukin-7 signaling R-HSA-1266695 7.185896e-01 0.144 0 0
Stimuli-sensing channels R-HSA-2672351 7.221941e-01 0.141 0 0
Cellular response to starvation R-HSA-9711097 7.245561e-01 0.140 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.252956e-01 0.139 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.282185e-01 0.138 0 0
G alpha (z) signalling events R-HSA-418597 7.282185e-01 0.138 0 0
Paracetamol ADME R-HSA-9753281 7.282185e-01 0.138 0 0
Metalloprotease DUBs R-HSA-5689901 7.298785e-01 0.137 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.298785e-01 0.137 0 0
Abacavir ADME R-HSA-2161522 7.298785e-01 0.137 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.298785e-01 0.137 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.298785e-01 0.137 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.407151e-01 0.130 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.407151e-01 0.130 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.407151e-01 0.130 0 0
Packaging Of Telomere Ends R-HSA-171306 7.407151e-01 0.130 0 0
Cristae formation R-HSA-8949613 7.407151e-01 0.130 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.407151e-01 0.130 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.407151e-01 0.130 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.407151e-01 0.130 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.407151e-01 0.130 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 7.407151e-01 0.130 0 0
Insulin processing R-HSA-264876 7.407151e-01 0.130 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.407151e-01 0.130 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.410796e-01 0.130 0 0
Ion channel transport R-HSA-983712 7.454778e-01 0.128 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.485632e-01 0.126 0 0
HIV elongation arrest and recovery R-HSA-167287 7.511177e-01 0.124 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.511177e-01 0.124 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.511177e-01 0.124 0 0
Prednisone ADME R-HSA-9757110 7.511177e-01 0.124 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.511177e-01 0.124 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.511177e-01 0.124 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.514078e-01 0.124 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.514078e-01 0.124 0 0
Peptide chain elongation R-HSA-156902 7.574005e-01 0.121 0 0
Triglyceride metabolism R-HSA-8979227 7.587502e-01 0.120 0 0
Late endosomal microautophagy R-HSA-9615710 7.611035e-01 0.119 0 0
mRNA Capping R-HSA-72086 7.611035e-01 0.119 0 0
Thyroxine biosynthesis R-HSA-209968 7.611035e-01 0.119 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 7.611035e-01 0.119 0 0
Platelet calcium homeostasis R-HSA-418360 7.611035e-01 0.119 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.616949e-01 0.118 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.659044e-01 0.116 0 0
GABA receptor activation R-HSA-977443 7.659044e-01 0.116 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.693669e-01 0.114 0 0
Downstream TCR signaling R-HSA-202424 7.693669e-01 0.114 0 0
Neurotransmitter release cycle R-HSA-112310 7.693669e-01 0.114 0 0
Base Excision Repair R-HSA-73884 7.693669e-01 0.114 0 0
Activation of the pre-replicative complex R-HSA-68962 7.706892e-01 0.113 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.706892e-01 0.113 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.706892e-01 0.113 0 0
Activation of BH3-only proteins R-HSA-114452 7.706892e-01 0.113 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.706892e-01 0.113 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.706892e-01 0.113 0 0
Neurotransmitter clearance R-HSA-112311 7.706892e-01 0.113 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.721448e-01 0.112 0 0
Interferon alpha/beta signaling R-HSA-909733 7.721448e-01 0.112 0 0
Aquaporin-mediated transport R-HSA-445717 7.728735e-01 0.112 0 0
Collagen degradation R-HSA-1442490 7.728735e-01 0.112 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.751672e-01 0.111 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.796609e-01 0.108 0 0
Signaling by PDGF R-HSA-186797 7.796609e-01 0.108 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.798909e-01 0.108 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.798909e-01 0.108 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.798909e-01 0.108 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.798909e-01 0.108 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.808475e-01 0.107 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.858838e-01 0.105 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.862699e-01 0.104 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.862699e-01 0.104 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.862699e-01 0.104 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.864089e-01 0.104 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.877908e-01 0.104 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.887238e-01 0.103 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.887238e-01 0.103 0 0
HS-GAG degradation R-HSA-2024096 7.887238e-01 0.103 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.887238e-01 0.103 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.887238e-01 0.103 0 0
DNA strand elongation R-HSA-69190 7.887238e-01 0.103 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.908124e-01 0.102 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 7.972028e-01 0.098 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.023950e-01 0.096 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.036734e-01 0.095 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.050608e-01 0.094 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.053421e-01 0.094 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.053421e-01 0.094 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.053421e-01 0.094 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.074958e-01 0.093 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.074958e-01 0.093 0 0
Eukaryotic Translation Termination R-HSA-72764 8.074958e-01 0.093 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 8.124853e-01 0.090 0 0
Dual Incision in GG-NER R-HSA-5696400 8.131551e-01 0.090 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.131551e-01 0.090 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.131551e-01 0.090 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.131551e-01 0.090 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.131551e-01 0.090 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.131551e-01 0.090 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.131551e-01 0.090 0 0
Mitophagy R-HSA-5205647 8.131551e-01 0.090 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.131551e-01 0.090 0 0
GPCR downstream signalling R-HSA-388396 8.139133e-01 0.089 0 0
Transcription of the HIV genome R-HSA-167172 8.167584e-01 0.088 0 0
Telomere Maintenance R-HSA-157579 8.173650e-01 0.088 0 0
Post-translational protein modification R-HSA-597592 8.183232e-01 0.087 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.206550e-01 0.086 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.206550e-01 0.086 0 0
Regulation of Apoptosis R-HSA-169911 8.206550e-01 0.086 0 0
PERK regulates gene expression R-HSA-381042 8.206550e-01 0.086 0 0
Signaling by GPCR R-HSA-372790 8.212277e-01 0.086 0 0
Regulation of insulin secretion R-HSA-422356 8.221364e-01 0.085 0 0
Innate Immune System R-HSA-168249 8.252014e-01 0.083 0 0
DNA Replication R-HSA-69306 8.273157e-01 0.082 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.278240e-01 0.082 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.278543e-01 0.082 0 0
RNA Polymerase III Transcription R-HSA-74158 8.278543e-01 0.082 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.278543e-01 0.082 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.278543e-01 0.082 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 8.331283e-01 0.079 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.347650e-01 0.078 0 0
Cleavage of the damaged purine R-HSA-110331 8.347650e-01 0.078 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.347650e-01 0.078 0 0
Selenocysteine synthesis R-HSA-2408557 8.358173e-01 0.078 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.382847e-01 0.077 0 0
MET promotes cell motility R-HSA-8875878 8.413987e-01 0.075 0 0
Depurination R-HSA-73927 8.413987e-01 0.075 0 0
Purine salvage R-HSA-74217 8.413987e-01 0.075 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 8.413987e-01 0.075 0 0
Elastic fibre formation R-HSA-1566948 8.413987e-01 0.075 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.413987e-01 0.075 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.432965e-01 0.074 0 0
Viral mRNA Translation R-HSA-192823 8.444263e-01 0.073 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.477665e-01 0.072 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.477665e-01 0.072 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.477665e-01 0.072 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.477665e-01 0.072 0 0
Signaling by TGFB family members R-HSA-9006936 8.519920e-01 0.070 0 0
RSV-host interactions R-HSA-9833110 8.526414e-01 0.069 0 0
Centrosome maturation R-HSA-380287 8.528995e-01 0.069 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.528995e-01 0.069 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.538789e-01 0.069 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.538789e-01 0.069 0 0
UCH proteinases R-HSA-5689603 8.574971e-01 0.067 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.597464e-01 0.066 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.597464e-01 0.066 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.597464e-01 0.066 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.597464e-01 0.066 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.604757e-01 0.065 0 0
Neddylation R-HSA-8951664 8.618984e-01 0.065 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.619631e-01 0.065 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.642543e-01 0.063 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.653785e-01 0.063 0 0
HIV Transcription Initiation R-HSA-167161 8.653785e-01 0.063 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.653785e-01 0.063 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.653785e-01 0.063 0 0
Signaling by FGFR1 in disease R-HSA-5655302 8.653785e-01 0.063 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.653785e-01 0.063 0 0
Translation of Structural Proteins R-HSA-9683701 8.653785e-01 0.063 0 0
Leishmania infection R-HSA-9658195 8.660219e-01 0.062 0 0
Parasitic Infection Pathways R-HSA-9824443 8.660219e-01 0.062 0 0
ABC transporter disorders R-HSA-5619084 8.663007e-01 0.062 0 0
Cholesterol biosynthesis R-HSA-191273 8.663007e-01 0.062 0 0
Interleukin-10 signaling R-HSA-6783783 8.663007e-01 0.062 0 0
SLC-mediated transport of organic anions R-HSA-9955298 8.663007e-01 0.062 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 8.705129e-01 0.060 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.705129e-01 0.060 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.707848e-01 0.060 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.707848e-01 0.060 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.707848e-01 0.060 0 0
Depyrimidination R-HSA-73928 8.707848e-01 0.060 0 0
Integration of energy metabolism R-HSA-163685 8.711124e-01 0.060 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.715422e-01 0.060 0 0
TCR signaling R-HSA-202403 8.750550e-01 0.058 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.759743e-01 0.058 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.759743e-01 0.058 0 0
Ribosome-associated quality control R-HSA-9948299 8.773845e-01 0.057 0 0
RMTs methylate histone arginines R-HSA-3214858 8.809557e-01 0.055 0 0
Proteasome assembly R-HSA-9907900 8.809557e-01 0.055 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.818260e-01 0.055 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.857373e-01 0.053 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.857373e-01 0.053 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.857373e-01 0.053 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 8.857373e-01 0.053 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 8.857373e-01 0.053 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.861687e-01 0.052 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.861687e-01 0.052 0 0
rRNA processing R-HSA-72312 8.893982e-01 0.051 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.903271e-01 0.050 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.903271e-01 0.050 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.903271e-01 0.050 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.933219e-01 0.049 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.947329e-01 0.048 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 8.947329e-01 0.048 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 8.973446e-01 0.047 0 0
NGF-stimulated transcription R-HSA-9031628 8.989619e-01 0.046 0 0
DNA Damage Bypass R-HSA-73893 9.030212e-01 0.044 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.030212e-01 0.044 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.030212e-01 0.044 0 0
Peptide hormone metabolism R-HSA-2980736 9.030214e-01 0.044 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.069177e-01 0.042 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.106579e-01 0.041 0 0
Orc1 removal from chromatin R-HSA-68949 9.142480e-01 0.039 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.142480e-01 0.039 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.142480e-01 0.039 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.150127e-01 0.039 0 0
Nucleotide biosynthesis R-HSA-8956320 9.176941e-01 0.037 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.210018e-01 0.036 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.210018e-01 0.036 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.232165e-01 0.035 0 0
TNF signaling R-HSA-75893 9.272245e-01 0.033 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.272245e-01 0.033 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 9.272245e-01 0.033 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.272245e-01 0.033 0 0
Infectious disease R-HSA-5663205 9.291018e-01 0.032 0 0
Dectin-2 family R-HSA-5621480 9.301498e-01 0.031 0 0
Potassium Channels R-HSA-1296071 9.328044e-01 0.030 0 0
Dual incision in TC-NER R-HSA-6782135 9.329576e-01 0.030 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.350181e-01 0.029 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.356528e-01 0.029 0 0
Peroxisomal protein import R-HSA-9033241 9.356528e-01 0.029 0 0
Extension of Telomeres R-HSA-180786 9.356528e-01 0.029 0 0
Glutathione conjugation R-HSA-156590 9.382398e-01 0.028 0 0
Metabolism of polyamines R-HSA-351202 9.382398e-01 0.028 0 0
Selenoamino acid metabolism R-HSA-2408522 9.393656e-01 0.027 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.431064e-01 0.025 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.450876e-01 0.025 0 0
Xenobiotics R-HSA-211981 9.475900e-01 0.023 0 0
Metabolism of nucleotides R-HSA-15869 9.497526e-01 0.022 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.509482e-01 0.022 0 0
G alpha (s) signalling events R-HSA-418555 9.512669e-01 0.022 0 0
Keratinization R-HSA-6805567 9.535452e-01 0.021 0 0
Platelet homeostasis R-HSA-418346 9.536611e-01 0.021 0 0
Kidney development R-HSA-9830369 9.536626e-01 0.021 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.536626e-01 0.021 0 0
Synthesis of DNA R-HSA-69239 9.552151e-01 0.020 0 0
ECM proteoglycans R-HSA-3000178 9.606807e-01 0.017 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.637810e-01 0.016 0 0
Ca2+ pathway R-HSA-4086398 9.637810e-01 0.016 0 0
Aspirin ADME R-HSA-9749641 9.637810e-01 0.016 0 0
Signaling by FGFR in disease R-HSA-1226099 9.652383e-01 0.015 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.652383e-01 0.015 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.666372e-01 0.015 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.671267e-01 0.015 0 0
Translation of Structural Proteins R-HSA-9694635 9.692684e-01 0.014 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.716925e-01 0.012 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.739256e-01 0.011 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.742203e-01 0.011 0 0
Interferon gamma signaling R-HSA-877300 9.756913e-01 0.011 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.769498e-01 0.010 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.791032e-01 0.009 0 0
G alpha (i) signalling events R-HSA-418594 9.809746e-01 0.008 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.812319e-01 0.008 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.836728e-01 0.007 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.847195e-01 0.007 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.847195e-01 0.007 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.849056e-01 0.007 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.849056e-01 0.007 0 0
FCGR activation R-HSA-2029481 9.853351e-01 0.006 0 0
Mitochondrial translation elongation R-HSA-5389840 9.875598e-01 0.005 0 0
Drug ADME R-HSA-9748784 9.878237e-01 0.005 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.879329e-01 0.005 0 0
Mitochondrial translation initiation R-HSA-5368286 9.885423e-01 0.005 0 0
Diseases of glycosylation R-HSA-3781865 9.894243e-01 0.005 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.906729e-01 0.004 0 0
Mitochondrial translation termination R-HSA-5419276 9.930078e-01 0.003 0 0
Antimicrobial peptides R-HSA-6803157 9.935606e-01 0.003 0 0
Extracellular matrix organization R-HSA-1474244 9.959117e-01 0.002 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.963827e-01 0.002 0 0
Regulation of Complement cascade R-HSA-977606 9.966689e-01 0.001 0 0
Metabolism of proteins R-HSA-392499 9.973749e-01 0.001 0 0
Sensory perception of taste R-HSA-9717189 9.976048e-01 0.001 0 0
Transport of small molecules R-HSA-382551 9.976762e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.979312e-01 0.001 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.982302e-01 0.001 0 0
Mitochondrial translation R-HSA-5368287 9.982780e-01 0.001 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.984037e-01 0.001 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.986557e-01 0.001 0 0
Complement cascade R-HSA-166658 9.987622e-01 0.001 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.989931e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.990080e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.990729e-01 0.000 0 0
Protein localization R-HSA-9609507 9.991104e-01 0.000 0 0
Translation R-HSA-72766 9.992947e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.995012e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.995884e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.996963e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.998095e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.998104e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999384e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999768e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999887e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999996e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999996e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999997e-01 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Cell Cycle Checkpoints R-HSA-69620 1.365574e-14 13.865 0 0
Mitotic Anaphase R-HSA-68882 6.095124e-14 13.215 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.682743e-14 13.114 0 0
Mitotic Prometaphase R-HSA-68877 1.512124e-13 12.820 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.530976e-12 11.123 0 0
Separation of Sister Chromatids R-HSA-2467813 2.541112e-11 10.595 0 0
Membrane Trafficking R-HSA-199991 6.888379e-11 10.162 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 7.880907e-11 10.103 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.792759e-10 9.746 0 0
Axon guidance R-HSA-422475 2.259007e-10 9.646 0 0
Apoptotic execution phase R-HSA-75153 4.263163e-10 9.370 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.687230e-09 8.773 0 0
Nervous system development R-HSA-9675108 1.606327e-09 8.794 0 0
G2/M Checkpoints R-HSA-69481 6.575771e-09 8.182 0 0
Signal Transduction R-HSA-162582 7.481233e-09 8.126 1 0
DNA Double Strand Break Response R-HSA-5693606 8.474218e-09 8.072 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.900375e-08 7.409 0 0
Mitotic Prophase R-HSA-68875 4.143092e-08 7.383 0 0
Apoptosis R-HSA-109581 4.287184e-08 7.368 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.970046e-08 7.304 0 0
Regulation of TP53 Activity R-HSA-5633007 6.587409e-08 7.181 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.434281e-08 7.129 0 0
Cellular responses to stress R-HSA-2262752 8.034795e-08 7.095 0 0
Recycling pathway of L1 R-HSA-437239 1.136471e-07 6.944 0 0
Cellular responses to stimuli R-HSA-8953897 1.313190e-07 6.882 0 0
Programmed Cell Death R-HSA-5357801 2.305521e-07 6.637 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.496824e-07 6.603 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.496824e-07 6.603 0 0
L1CAM interactions R-HSA-373760 2.503202e-07 6.602 0 0
Kinesins R-HSA-983189 2.629884e-07 6.580 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.111676e-07 6.507 0 0
G2/M Transition R-HSA-69275 3.433161e-07 6.464 0 0
Homology Directed Repair R-HSA-5693538 3.806869e-07 6.419 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.326114e-07 6.364 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.737013e-07 6.324 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.151136e-07 6.288 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.314630e-07 6.275 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 8.464617e-07 6.072 0 0
Post NMDA receptor activation events R-HSA-438064 1.072137e-06 5.970 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.356204e-06 5.868 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.440541e-06 5.841 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.693929e-06 5.771 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.158221e-06 5.666 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.180701e-06 5.661 0 0
Aggrephagy R-HSA-9646399 2.794421e-06 5.554 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.892492e-06 5.539 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.077570e-06 5.512 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.207735e-06 5.494 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.438187e-06 5.464 0 0
Cellular response to heat stress R-HSA-3371556 3.585241e-06 5.445 0 0
Cell-Cell communication R-HSA-1500931 3.661846e-06 5.436 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.354793e-06 5.361 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.801548e-06 5.319 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.561062e-06 5.255 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.199047e-06 5.208 0 0
Nucleosome assembly R-HSA-774815 6.199047e-06 5.208 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.465374e-06 5.189 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.809859e-06 5.167 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.620687e-06 5.118 0 0
Signaling by ROBO receptors R-HSA-376176 8.386894e-06 5.076 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 8.426849e-06 5.074 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.483269e-06 5.071 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.864867e-06 5.052 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.090617e-05 4.962 0 0
Ub-specific processing proteases R-HSA-5689880 1.230037e-05 4.910 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.230037e-05 4.910 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.230037e-05 4.910 0 0
Metabolism of RNA R-HSA-8953854 1.254245e-05 4.902 0 0
Deubiquitination R-HSA-5688426 1.549341e-05 4.810 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.754283e-05 4.756 0 0
Vesicle-mediated transport R-HSA-5653656 1.845146e-05 4.734 0 0
mRNA Splicing R-HSA-72172 2.028057e-05 4.693 0 0
Meiotic synapsis R-HSA-1221632 2.084567e-05 4.681 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.224171e-05 4.653 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.198006e-05 4.658 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.224171e-05 4.653 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.685195e-05 4.571 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.596818e-05 4.586 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.807498e-05 4.552 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.807498e-05 4.552 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.810911e-05 4.551 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.249869e-05 4.488 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.404371e-05 4.468 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.998648e-05 4.398 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.042028e-05 4.393 0 0
Interleukin-12 signaling R-HSA-9020591 4.209310e-05 4.376 0 0
Selective autophagy R-HSA-9663891 4.538831e-05 4.343 0 0
Meiosis R-HSA-1500620 4.766289e-05 4.322 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.523271e-05 4.258 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.663640e-05 4.247 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.663640e-05 4.247 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.861866e-05 4.232 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.094478e-05 4.215 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.533760e-05 4.185 0 0
Cell junction organization R-HSA-446728 6.423361e-05 4.192 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.228158e-05 4.206 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.678461e-05 4.175 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.730982e-05 4.172 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.730982e-05 4.172 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.193342e-05 4.143 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 8.107031e-05 4.091 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.107031e-05 4.091 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 8.908951e-05 4.050 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 8.908951e-05 4.050 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 9.120726e-05 4.040 0 0
MHC class II antigen presentation R-HSA-2132295 9.858596e-05 4.006 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.006041e-04 3.997 0 0
Signaling by ALK in cancer R-HSA-9700206 1.006041e-04 3.997 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.635298e-05 4.016 0 0
Diseases of programmed cell death R-HSA-9645723 1.018000e-04 3.992 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.034520e-04 3.985 0 0
DNA Repair R-HSA-73894 1.046086e-04 3.980 0 0
Host Interactions of HIV factors R-HSA-162909 1.145606e-04 3.941 0 0
Nuclear import of Rev protein R-HSA-180746 1.231794e-04 3.909 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.441108e-04 3.841 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.454635e-04 3.837 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.616281e-04 3.791 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.746293e-04 3.758 0 0
Adherens junctions interactions R-HSA-418990 1.851446e-04 3.732 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.947915e-04 3.710 0 0
Cellular Senescence R-HSA-2559583 1.949836e-04 3.710 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.147337e-04 3.668 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.147337e-04 3.668 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.147337e-04 3.668 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.147337e-04 3.668 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.340115e-04 3.631 0 0
Signaling by Hippo R-HSA-2028269 2.420699e-04 3.616 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.493687e-04 3.603 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.624979e-04 3.581 0 0
p75NTR signals via NF-kB R-HSA-193639 2.638530e-04 3.579 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.638530e-04 3.579 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.736453e-04 3.563 0 0
Striated Muscle Contraction R-HSA-390522 2.706690e-04 3.568 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.750499e-04 3.561 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.888775e-04 3.539 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.877001e-04 3.541 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.832905e-04 3.548 0 0
Gap junction trafficking R-HSA-190828 2.972813e-04 3.527 0 0
Rab regulation of trafficking R-HSA-9007101 3.126161e-04 3.505 0 0
Ribosome-associated quality control R-HSA-9948299 3.307028e-04 3.481 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.351520e-04 3.475 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.351520e-04 3.475 0 0
Regulation of CDH1 Function R-HSA-9764561 3.515087e-04 3.454 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.586682e-04 3.445 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.586682e-04 3.445 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.703547e-04 3.431 0 0
Gap junction trafficking and regulation R-HSA-157858 3.718829e-04 3.430 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.765514e-04 3.424 0 0
Centrosome maturation R-HSA-380287 4.168376e-04 3.380 0 0
Interleukin-12 family signaling R-HSA-447115 3.974853e-04 3.401 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.294919e-04 3.367 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.319702e-04 3.365 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.351443e-04 3.361 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.351443e-04 3.361 0 0
Translation initiation complex formation R-HSA-72649 4.493915e-04 3.347 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.642755e-04 3.333 0 0
HIV Infection R-HSA-162906 4.663526e-04 3.331 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.734161e-04 3.325 0 0
Macroautophagy R-HSA-1632852 4.839522e-04 3.315 0 0
Hedgehog 'off' state R-HSA-5610787 4.952355e-04 3.305 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.013098e-04 3.300 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.056416e-04 3.296 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.059751e-04 3.296 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.515672e-04 3.258 0 0
Chromatin organization R-HSA-4839726 5.406820e-04 3.267 0 0
HDACs deacetylate histones R-HSA-3214815 5.529308e-04 3.257 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.664029e-04 3.247 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.851085e-04 3.233 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.851085e-04 3.233 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.851085e-04 3.233 0 0
Signaling by NOTCH R-HSA-157118 6.088127e-04 3.216 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.285686e-04 3.202 0 0
RAB geranylgeranylation R-HSA-8873719 6.423658e-04 3.192 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.423658e-04 3.192 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.450690e-04 3.190 0 0
Cell-cell junction organization R-HSA-421270 6.496466e-04 3.187 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.236270e-04 3.140 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 7.020850e-04 3.154 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.847055e-04 3.164 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.657560e-04 3.177 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.657560e-04 3.177 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.106179e-04 3.148 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.373191e-04 3.132 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.609229e-04 3.119 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.722099e-04 3.112 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.722099e-04 3.112 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 8.664120e-04 3.062 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.984212e-04 3.047 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.074195e-04 3.042 0 0
Packaging Of Telomere Ends R-HSA-171306 9.147267e-04 3.039 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.147267e-04 3.039 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.284435e-04 3.032 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.705630e-04 3.013 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.798463e-04 3.009 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.798463e-04 3.009 0 0
Cilium Assembly R-HSA-5617833 9.964575e-04 3.002 0 0
Autophagy R-HSA-9612973 1.004512e-03 2.998 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.008447e-03 2.996 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.013754e-03 2.994 0 0
HIV Life Cycle R-HSA-162587 1.121502e-03 2.950 0 0
Neurodegenerative Diseases R-HSA-8863678 1.136782e-03 2.944 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.136782e-03 2.944 0 0
MAPK family signaling cascades R-HSA-5683057 1.102930e-03 2.957 0 0
Signaling by VEGF R-HSA-194138 1.037266e-03 2.984 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.136782e-03 2.944 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.159530e-03 2.936 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.163514e-03 2.934 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.163514e-03 2.934 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.163514e-03 2.934 0 0
Signaling by RAS mutants R-HSA-6802949 1.163514e-03 2.934 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.197707e-03 2.922 0 0
Metabolism of non-coding RNA R-HSA-194441 1.201962e-03 2.920 0 0
snRNP Assembly R-HSA-191859 1.201962e-03 2.920 0 0
Stabilization of p53 R-HSA-69541 1.236088e-03 2.908 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.242154e-03 2.906 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.245913e-03 2.905 0 0
Meiotic recombination R-HSA-912446 1.356872e-03 2.867 0 0
Chromatin modifying enzymes R-HSA-3247509 1.439934e-03 2.842 0 0
Influenza Infection R-HSA-168255 1.517843e-03 2.819 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.543469e-03 2.812 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.545167e-03 2.811 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.545167e-03 2.811 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.545167e-03 2.811 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.569147e-03 2.804 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.572677e-03 2.803 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.592103e-03 2.798 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.722807e-03 2.764 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.729876e-03 2.762 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.978508e-03 2.704 0 0
Peptide chain elongation R-HSA-156902 1.905876e-03 2.720 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.916966e-03 2.717 0 0
Glycolysis R-HSA-70171 1.866587e-03 2.729 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.020915e-03 2.694 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.040271e-03 2.690 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.098288e-03 2.678 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.239068e-03 2.650 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.242853e-03 2.649 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.242853e-03 2.649 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.361053e-03 2.627 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.463502e-03 2.608 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.480873e-03 2.605 0 0
Gap junction assembly R-HSA-190861 2.541667e-03 2.595 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.541667e-03 2.595 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.578303e-03 2.589 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.722934e-03 2.565 0 0
Diseases of DNA repair R-HSA-9675135 2.722934e-03 2.565 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.781187e-03 2.556 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.809445e-03 2.551 0 0
HCMV Early Events R-HSA-9609690 2.865418e-03 2.543 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.875159e-03 2.541 0 0
NF-kB is activated and signals survival R-HSA-209560 2.875159e-03 2.541 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.875159e-03 2.541 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.940919e-03 2.532 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.200063e-03 2.495 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.222241e-03 2.492 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.265092e-03 2.486 0 0
Chromosome Maintenance R-HSA-73886 3.268490e-03 2.486 0 0
Signaling by WNT R-HSA-195721 3.422170e-03 2.466 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.864756e-03 2.413 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.154638e-03 2.381 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.154638e-03 2.381 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.917584e-03 2.407 0 0
Co-inhibition by PD-1 R-HSA-389948 4.063175e-03 2.391 0 0
EPH-Ephrin signaling R-HSA-2682334 3.766404e-03 2.424 0 0
S Phase R-HSA-69242 3.590566e-03 2.445 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.079780e-03 2.389 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.917584e-03 2.407 0 0
Cellular response to chemical stress R-HSA-9711123 4.050091e-03 2.393 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.082400e-03 2.389 0 0
DNA methylation R-HSA-5334118 4.190882e-03 2.378 0 0
Late endosomal microautophagy R-HSA-9615710 4.190882e-03 2.378 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.190882e-03 2.378 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.236035e-03 2.373 0 0
Signaling by NOTCH1 R-HSA-1980143 4.325255e-03 2.364 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.335746e-03 2.363 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.702996e-03 2.328 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.702996e-03 2.328 0 0
Cleavage of the damaged purine R-HSA-110331 4.805098e-03 2.318 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.889895e-03 2.311 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.889895e-03 2.311 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.889895e-03 2.311 0 0
Pexophagy R-HSA-9664873 4.889895e-03 2.311 0 0
Gene Silencing by RNA R-HSA-211000 5.033337e-03 2.298 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.143780e-03 2.289 0 0
Interleukin-37 signaling R-HSA-9008059 5.258506e-03 2.279 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.271809e-03 2.278 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.271809e-03 2.278 0 0
Regulation of PTEN localization R-HSA-8948747 5.376305e-03 2.270 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.399249e-03 2.268 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.488112e-03 2.261 0 0
Signaling by Hedgehog R-HSA-5358351 5.493172e-03 2.260 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.505941e-03 2.259 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.559850e-03 2.255 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.609570e-03 2.251 0 0
Developmental Biology R-HSA-1266738 5.785861e-03 2.238 0 0
Depurination R-HSA-73927 5.849145e-03 2.233 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.987167e-03 2.223 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.987167e-03 2.223 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.987167e-03 2.223 0 0
Signaling by NOTCH3 R-HSA-9012852 6.020047e-03 2.220 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.062557e-03 2.217 0 0
Signaling by NOTCH4 R-HSA-9013694 6.324703e-03 2.199 0 0
Death Receptor Signaling R-HSA-73887 6.383469e-03 2.195 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.617512e-03 2.179 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.896503e-03 2.161 0 0
Nephrin family interactions R-HSA-373753 6.896503e-03 2.161 0 0
PKR-mediated signaling R-HSA-9833482 7.429603e-03 2.129 0 0
Protein folding R-HSA-391251 6.902472e-03 2.161 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.201122e-03 2.143 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.569329e-03 2.121 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.277160e-03 2.082 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.042871e-03 2.152 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.042871e-03 2.152 0 0
Muscle contraction R-HSA-397014 7.578020e-03 2.120 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.860848e-03 2.105 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 8.370338e-03 2.077 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 8.598606e-03 2.066 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.036758e-03 2.044 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 9.088567e-03 2.042 0 0
Signaling by MAPK mutants R-HSA-9652817 9.088567e-03 2.042 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.153026e-03 2.038 0 0
G1/S Transition R-HSA-69206 9.386752e-03 2.027 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 9.813331e-03 2.008 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 9.813331e-03 2.008 0 0
Degradation of CDH1 R-HSA-9766229 9.951862e-03 2.002 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.011454e-02 1.995 0 0
Reproduction R-HSA-1474165 1.018602e-02 1.992 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.023589e-02 1.990 0 0
Glucose metabolism R-HSA-70326 1.060672e-02 1.974 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.093285e-02 1.961 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.093285e-02 1.961 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.096759e-02 1.960 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.096759e-02 1.960 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.098666e-02 1.959 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.098666e-02 1.959 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.116745e-02 1.952 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.116745e-02 1.952 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.116745e-02 1.952 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.134538e-02 1.945 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.134538e-02 1.945 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.134538e-02 1.945 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.165701e-02 1.933 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.187457e-02 1.925 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.198294e-02 1.921 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.198294e-02 1.921 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.203001e-02 1.920 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.208222e-02 1.918 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.210525e-02 1.917 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.218179e-02 1.914 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.444812e-02 1.840 0 0
Prolonged ERK activation events R-HSA-169893 1.474164e-02 1.831 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 1.425348e-02 1.846 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.543927e-02 1.811 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.550376e-02 1.810 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.550376e-02 1.810 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.425548e-02 1.846 0 0
Myogenesis R-HSA-525793 1.356604e-02 1.868 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.274949e-02 1.895 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.240469e-02 1.906 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.425548e-02 1.846 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.410876e-02 1.851 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.360091e-02 1.866 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.274949e-02 1.895 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.242815e-02 1.906 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.503699e-02 1.823 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.345957e-02 1.871 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.281459e-02 1.892 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.411060e-02 1.850 0 0
Depyrimidination R-HSA-73928 1.411060e-02 1.850 0 0
Orc1 removal from chromatin R-HSA-68949 1.560554e-02 1.807 0 0
Interferon Signaling R-HSA-913531 1.582607e-02 1.801 0 0
Signaling by Interleukins R-HSA-449147 1.611488e-02 1.793 0 0
Defective pyroptosis R-HSA-9710421 1.651970e-02 1.782 0 0
TBC/RABGAPs R-HSA-8854214 1.651970e-02 1.782 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.660503e-02 1.780 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.698951e-02 1.770 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.698951e-02 1.770 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.703968e-02 1.769 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.763942e-02 1.754 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.768501e-02 1.752 0 0
Smooth Muscle Contraction R-HSA-445355 1.796169e-02 1.746 0 0
Negative regulation of MET activity R-HSA-6807004 1.856955e-02 1.731 0 0
Eukaryotic Translation Termination R-HSA-72764 1.873778e-02 1.727 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.892941e-02 1.723 0 0
Regulated Necrosis R-HSA-5218859 1.900678e-02 1.721 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.908097e-02 1.719 0 0
Nucleotide Excision Repair R-HSA-5696398 2.011626e-02 1.696 0 0
ESR-mediated signaling R-HSA-8939211 2.027714e-02 1.693 0 0
Selenocysteine synthesis R-HSA-2408557 2.043551e-02 1.690 0 0
Interleukin-1 family signaling R-HSA-446652 2.060399e-02 1.686 0 0
Neutrophil degranulation R-HSA-6798695 2.064451e-02 1.685 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.132335e-02 1.671 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.132335e-02 1.671 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.132335e-02 1.671 0 0
FLT3 Signaling R-HSA-9607240 2.132335e-02 1.671 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.135524e-02 1.670 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.159795e-02 1.666 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.561069e-02 1.592 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.561069e-02 1.592 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.561069e-02 1.592 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.561069e-02 1.592 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.561069e-02 1.592 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.561069e-02 1.592 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.561069e-02 1.592 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.561069e-02 1.592 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.561069e-02 1.592 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.561069e-02 1.592 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.561069e-02 1.592 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.521783e-02 1.598 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.421793e-02 1.616 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.421793e-02 1.616 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.479909e-02 1.606 0 0
ERK/MAPK targets R-HSA-198753 2.312645e-02 1.636 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.843005e-02 1.546 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.843005e-02 1.546 0 0
Long-term potentiation R-HSA-9620244 2.631476e-02 1.580 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.361089e-02 1.627 0 0
MAP2K and MAPK activation R-HSA-5674135 2.478477e-02 1.606 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.297989e-02 1.639 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.941323e-02 1.531 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.250705e-02 1.648 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.361089e-02 1.627 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.408402e-02 1.618 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.207912e-02 1.656 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.698193e-02 1.569 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.698193e-02 1.569 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.668924e-02 1.574 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.402938e-02 1.619 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.478477e-02 1.606 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.864669e-02 1.543 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.408402e-02 1.618 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.382167e-02 1.623 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.382167e-02 1.623 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.382167e-02 1.623 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.382167e-02 1.623 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.656667e-02 1.576 0 0
MAP kinase activation R-HSA-450294 2.692456e-02 1.570 0 0
DNA Replication R-HSA-69306 2.226455e-02 1.652 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.519376e-02 1.599 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.521783e-02 1.598 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.903889e-02 1.537 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.519376e-02 1.599 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.519376e-02 1.599 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.941323e-02 1.531 0 0
Hedgehog 'on' state R-HSA-5632684 2.698193e-02 1.569 0 0
NrCAM interactions R-HSA-447038 2.521783e-02 1.598 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.382167e-02 1.623 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.312645e-02 1.636 0 0
mRNA 3'-end processing R-HSA-72187 2.991861e-02 1.524 0 0
tRNA processing in the nucleus R-HSA-6784531 3.032179e-02 1.518 0 0
Ephrin signaling R-HSA-3928664 3.035595e-02 1.518 0 0
RAF activation R-HSA-5673000 3.062287e-02 1.514 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.062287e-02 1.514 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.062287e-02 1.514 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.072253e-02 1.513 0 0
RSK activation R-HSA-444257 3.072253e-02 1.513 0 0
Formation of annular gap junctions R-HSA-196025 3.072253e-02 1.513 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.072253e-02 1.513 0 0
Metalloprotease DUBs R-HSA-5689901 3.160531e-02 1.500 0 0
HCMV Infection R-HSA-9609646 3.166391e-02 1.499 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.180749e-02 1.497 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.226156e-02 1.491 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.246013e-02 1.489 0 0
Gene expression (Transcription) R-HSA-74160 3.272292e-02 1.485 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.385189e-02 1.470 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.391821e-02 1.470 0 0
Trafficking of AMPA receptors R-HSA-399719 3.397133e-02 1.469 0 0
EGFR downregulation R-HSA-182971 3.397133e-02 1.469 0 0
Signaling by PTK6 R-HSA-8848021 3.402819e-02 1.468 1 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.402819e-02 1.468 1 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.453279e-02 1.462 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.568746e-02 1.447 0 0
Regulation of Apoptosis R-HSA-169911 3.568746e-02 1.447 0 0
Signalling to ERKs R-HSA-187687 3.568746e-02 1.447 0 0
Oncogene Induced Senescence R-HSA-2559585 3.568746e-02 1.447 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.688393e-02 1.433 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.688393e-02 1.433 0 0
Rap1 signalling R-HSA-392517 3.742429e-02 1.427 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.760230e-02 1.425 0 0
Ion transport by P-type ATPases R-HSA-936837 3.805804e-02 1.420 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.805804e-02 1.420 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.817786e-02 1.418 0 0
Maturation of protein E R-HSA-9694493 3.817786e-02 1.418 0 0
Maturation of protein E R-HSA-9683683 3.817786e-02 1.418 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.829494e-02 1.417 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.960460e-02 1.402 0 0
Viral mRNA Translation R-HSA-192823 3.960567e-02 1.402 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.971367e-02 1.401 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.971367e-02 1.401 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.971367e-02 1.401 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.971367e-02 1.401 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.971367e-02 1.401 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.971367e-02 1.401 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.971367e-02 1.401 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.977200e-02 1.400 0 0
G0 and Early G1 R-HSA-1538133 3.980120e-02 1.400 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.980120e-02 1.400 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.003014e-02 1.398 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 4.003014e-02 1.398 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.003014e-02 1.398 0 0
Negative regulation of FLT3 R-HSA-9706369 4.003014e-02 1.398 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.048826e-02 1.393 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.072263e-02 1.390 0 0
MET interacts with TNS proteins R-HSA-8875513 4.469080e-02 1.350 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.431263e-02 1.265 0 0
Signaling by LTK in cancer R-HSA-9842640 5.431263e-02 1.265 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.431263e-02 1.265 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.431263e-02 1.265 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.195216e-02 1.377 0 0
Gap junction degradation R-HSA-190873 4.195216e-02 1.377 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.186554e-02 1.378 0 0
Repression of WNT target genes R-HSA-4641265 4.186554e-02 1.378 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.186554e-02 1.378 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.186554e-02 1.378 0 0
Frs2-mediated activation R-HSA-170968 5.309635e-02 1.275 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.468453e-02 1.262 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.468453e-02 1.262 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.468453e-02 1.262 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.629115e-02 1.335 0 0
Activation of the pre-replicative complex R-HSA-68962 6.017195e-02 1.221 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.306533e-02 1.366 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.824484e-02 1.317 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.441189e-02 1.264 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.441189e-02 1.264 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.441189e-02 1.264 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.776975e-02 1.321 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.077457e-02 1.216 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.189315e-02 1.378 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.588073e-02 1.253 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.588073e-02 1.253 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.588073e-02 1.253 0 0
CaM pathway R-HSA-111997 4.131855e-02 1.384 0 0
Calmodulin induced events R-HSA-111933 4.131855e-02 1.384 0 0
Signaling by NOTCH2 R-HSA-1980145 6.135142e-02 1.212 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.185693e-02 1.285 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.437849e-02 1.265 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.211111e-02 1.283 0 0
Cellular response to hypoxia R-HSA-1234174 4.242500e-02 1.372 0 0
Signaling by ERBB2 R-HSA-1227986 4.282725e-02 1.368 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.629115e-02 1.335 0 0
Ca-dependent events R-HSA-111996 5.476076e-02 1.262 0 0
Telomere Maintenance R-HSA-157579 5.853449e-02 1.233 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.384763e-02 1.269 0 0
Signaling by EGFR R-HSA-177929 4.824484e-02 1.317 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.286450e-02 1.368 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.806560e-02 1.236 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.326439e-02 1.274 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.033797e-02 1.219 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.309635e-02 1.275 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.852363e-02 1.314 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.642108e-02 1.249 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.376180e-02 1.359 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.186554e-02 1.378 0 0
Regulation of IFNG signaling R-HSA-877312 4.186554e-02 1.378 0 0
TCR signaling R-HSA-202403 4.924200e-02 1.308 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.853449e-02 1.233 0 0
G alpha (12/13) signalling events R-HSA-416482 5.510888e-02 1.259 0 0
MTOR signalling R-HSA-165159 5.476076e-02 1.262 0 0
RNA Polymerase II Transcription R-HSA-73857 4.393806e-02 1.357 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.613470e-02 1.336 0 0
Josephin domain DUBs R-HSA-5689877 5.536049e-02 1.257 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.135142e-02 1.212 0 0
Intraflagellar transport R-HSA-5620924 6.144897e-02 1.211 0 0
PCP/CE pathway R-HSA-4086400 5.510888e-02 1.259 0 0
Interleukin-1 signaling R-HSA-9020702 5.234452e-02 1.281 0 0
Transmission across Chemical Synapses R-HSA-112315 5.326439e-02 1.274 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 4.754147e-02 1.323 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.155352e-02 1.288 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.674812e-02 1.330 0 0
Semaphorin interactions R-HSA-373755 5.883859e-02 1.230 0 0
Amyloid fiber formation R-HSA-977225 4.465324e-02 1.350 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.776975e-02 1.321 0 0
Base Excision Repair R-HSA-73884 4.270258e-02 1.370 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.346729e-02 1.272 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.468453e-02 1.262 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.100544e-02 1.292 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.591951e-02 1.181 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.628470e-02 1.179 0 0
Cellular response to starvation R-HSA-9711097 6.674331e-02 1.176 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.775721e-02 1.169 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.787006e-02 1.168 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 6.906759e-02 1.161 0 0
NADE modulates death signalling R-HSA-205025 6.906759e-02 1.161 0 0
Signaling by MAP2K mutants R-HSA-9652169 6.906759e-02 1.161 0 0
Budding and maturation of HIV virion R-HSA-162588 6.930712e-02 1.159 0 0
Interleukin-17 signaling R-HSA-448424 6.973390e-02 1.157 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.973390e-02 1.157 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 6.996068e-02 1.155 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.014896e-02 1.154 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.085441e-02 1.150 0 0
PECAM1 interactions R-HSA-210990 7.096523e-02 1.149 0 0
Polo-like kinase mediated events R-HSA-156711 7.248833e-02 1.140 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.331489e-02 1.135 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.358022e-02 1.133 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.358022e-02 1.133 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.358022e-02 1.133 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.358022e-02 1.133 0 0
MECP2 regulates transcription factors R-HSA-9022707 7.358022e-02 1.133 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.400758e-02 1.131 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.414870e-02 1.130 0 0
mTORC1-mediated signalling R-HSA-166208 7.632876e-02 1.117 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.632876e-02 1.117 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 7.775972e-02 1.109 0 0
Adaptive Immune System R-HSA-1280218 7.781747e-02 1.109 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.874516e-02 1.104 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 7.874516e-02 1.104 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.874516e-02 1.104 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.874516e-02 1.104 0 0
RUNX2 regulates bone development R-HSA-8941326 7.930728e-02 1.101 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.055455e-02 1.094 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.055455e-02 1.094 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.055455e-02 1.094 0 0
TNF signaling R-HSA-75893 8.281788e-02 1.082 0 0
Ion homeostasis R-HSA-5578775 8.281788e-02 1.082 0 0
NRAGE signals death through JNK R-HSA-193648 8.281788e-02 1.082 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.375087e-02 1.077 0 0
HSF1-dependent transactivation R-HSA-3371571 8.480395e-02 1.072 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.598228e-02 1.066 0 0
Translesion Synthesis by POLH R-HSA-110320 8.598228e-02 1.066 0 0
Regulation of signaling by CBL R-HSA-912631 8.598228e-02 1.066 0 0
G-protein mediated events R-HSA-112040 8.599418e-02 1.066 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.662160e-02 1.062 0 0
RNA Polymerase I Transcription R-HSA-73864 8.784495e-02 1.056 0 0
Heme signaling R-HSA-9707616 8.859855e-02 1.053 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.873152e-02 1.052 0 0
Integration of provirus R-HSA-162592 8.873152e-02 1.052 0 0
Growth hormone receptor signaling R-HSA-982772 8.883128e-02 1.051 0 0
Degradation of DVL R-HSA-4641258 8.939825e-02 1.049 0 0
Degradation of AXIN R-HSA-4641257 8.939825e-02 1.049 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.001342e-02 1.046 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 9.008422e-02 1.045 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.008422e-02 1.045 0 0
Generic Transcription Pathway R-HSA-212436 9.258466e-02 1.033 0 0
Circadian clock R-HSA-9909396 9.470376e-02 1.024 0 0
Sensory processing of sound R-HSA-9659379 9.527113e-02 1.021 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 9.583447e-02 1.018 0 0
Regulation by c-FLIP R-HSA-3371378 9.583447e-02 1.018 0 0
Dimerization of procaspase-8 R-HSA-69416 9.583447e-02 1.018 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 9.583447e-02 1.018 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 9.583447e-02 1.018 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 9.583447e-02 1.018 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 9.583447e-02 1.018 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 9.583447e-02 1.018 0 0
Modulation by Mtb of host immune system R-HSA-9637628 9.583447e-02 1.018 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.676598e-02 1.014 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 9.676598e-02 1.014 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.758689e-02 1.011 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 9.819355e-02 1.008 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 9.819355e-02 1.008 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 9.819355e-02 1.008 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.003392e-01 0.999 0 0
Signaling by NTRKs R-HSA-166520 1.003392e-01 0.999 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.008064e-01 0.997 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.008064e-01 0.997 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.008064e-01 0.997 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.017325e-01 0.993 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.017325e-01 0.993 0 0
Deadenylation of mRNA R-HSA-429947 1.024484e-01 0.989 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.024484e-01 0.989 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.025808e-01 0.989 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.025808e-01 0.989 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.025808e-01 0.989 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.025808e-01 0.989 0 0
Downstream TCR signaling R-HSA-202424 1.031118e-01 0.987 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.055253e-01 0.977 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.055253e-01 0.977 0 0
Viral Infection Pathways R-HSA-9824446 1.057005e-01 0.976 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.065732e-01 0.972 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.065732e-01 0.972 0 0
Protein ubiquitination R-HSA-8852135 1.069518e-01 0.971 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.085772e-01 0.964 0 0
Pervasive developmental disorders R-HSA-9005895 1.085772e-01 0.964 0 0
Disorders of Nervous System Development R-HSA-9697154 1.085772e-01 0.964 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.085772e-01 0.964 0 0
PTEN Regulation R-HSA-6807070 1.085859e-01 0.964 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.090913e-01 0.962 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.090913e-01 0.962 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.108179e-01 0.955 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.108179e-01 0.955 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.109498e-01 0.955 0 0
Signaling by ALK R-HSA-201556 1.118151e-01 0.951 0 0
Dual Incision in GG-NER R-HSA-5696400 1.142133e-01 0.942 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.145753e-01 0.941 0 0
Disorders of Developmental Biology R-HSA-9675151 1.145753e-01 0.941 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.160945e-01 0.935 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.201535e-01 0.920 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.205404e-01 0.919 0 0
ARMS-mediated activation R-HSA-170984 1.208464e-01 0.918 0 0
Lipophagy R-HSA-9613354 1.208464e-01 0.918 0 0
MAPK1 (ERK2) activation R-HSA-112411 1.208464e-01 0.918 0 0
CASP8 activity is inhibited R-HSA-5218900 1.208464e-01 0.918 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.208464e-01 0.918 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.208464e-01 0.918 0 0
Hemostasis R-HSA-109582 1.221564e-01 0.913 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.241286e-01 0.906 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.241286e-01 0.906 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.241286e-01 0.906 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.275131e-01 0.894 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.275881e-01 0.894 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.275881e-01 0.894 0 0
Platelet degranulation R-HSA-114608 1.296800e-01 0.887 0 0
SARS-CoV Infections R-HSA-9679506 1.297453e-01 0.887 0 0
Regulation of TP53 Expression R-HSA-6804754 1.300937e-01 0.886 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.300937e-01 0.886 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.300937e-01 0.886 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.305337e-01 0.884 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.305337e-01 0.884 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.313690e-01 0.882 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.313690e-01 0.882 0 0
DAG and IP3 signaling R-HSA-1489509 1.326440e-01 0.877 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.326440e-01 0.877 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.329369e-01 0.876 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.329369e-01 0.876 0 0
Mitochondrial biogenesis R-HSA-1592230 1.329432e-01 0.876 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.343045e-01 0.872 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.347831e-01 0.870 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.347831e-01 0.870 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.371618e-01 0.863 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.400082e-01 0.854 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.400082e-01 0.854 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.406307e-01 0.852 0 0
RET signaling R-HSA-8853659 1.416114e-01 0.849 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.419298e-01 0.848 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.425912e-01 0.846 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 1.441489e-01 0.841 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.446007e-01 0.840 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.446007e-01 0.840 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.446007e-01 0.840 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.446007e-01 0.840 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.446007e-01 0.840 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.446007e-01 0.840 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.446007e-01 0.840 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.446007e-01 0.840 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.446007e-01 0.840 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.446007e-01 0.840 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.682992e-01 0.571 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.682992e-01 0.571 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.682992e-01 0.571 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.682992e-01 0.571 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.682992e-01 0.571 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.682992e-01 0.571 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.682992e-01 0.571 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.682992e-01 0.571 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.682992e-01 0.571 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.682992e-01 0.571 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.682992e-01 0.571 0 0
Hereditary fructose intolerance R-HSA-5657560 2.682992e-01 0.571 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.682992e-01 0.571 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.843507e-01 0.734 0 0
FasL/ CD95L signaling R-HSA-75157 1.843507e-01 0.734 0 0
Axonal growth stimulation R-HSA-209563 1.843507e-01 0.734 0 0
MET activates PTPN11 R-HSA-8865999 1.843507e-01 0.734 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.678263e-01 0.775 1 1
Erythropoietin activates STAT5 R-HSA-9027283 1.678263e-01 0.775 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.411102e-01 0.618 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.411102e-01 0.618 0 0
PI3K/AKT activation R-HSA-198203 1.483256e-01 0.829 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.483256e-01 0.829 0 0
2-LTR circle formation R-HSA-164843 1.483256e-01 0.829 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.483256e-01 0.829 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.483256e-01 0.829 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.067889e-01 0.684 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.067889e-01 0.684 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.067889e-01 0.684 0 0
PTK6 Expression R-HSA-8849473 2.067889e-01 0.684 0 0
Disinhibition of SNARE formation R-HSA-114516 2.067889e-01 0.684 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.779399e-01 0.750 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.539804e-01 0.813 0 0
MET receptor recycling R-HSA-8875656 2.475110e-01 0.606 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.093327e-01 0.679 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.093327e-01 0.679 0 0
ERKs are inactivated R-HSA-202670 2.093327e-01 0.679 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 1.791976e-01 0.747 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.791976e-01 0.747 0 0
Notch-HLH transcription pathway R-HSA-350054 1.528690e-01 0.816 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.767447e-01 0.753 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.767447e-01 0.753 0 0
Translesion synthesis by POLI R-HSA-5656121 2.058276e-01 0.686 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.421383e-01 0.616 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.421383e-01 0.616 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 2.893028e-01 0.539 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.893028e-01 0.539 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 2.893028e-01 0.539 0 0
ALK mutants bind TKIs R-HSA-9700645 2.893028e-01 0.539 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.497348e-01 0.825 0 0
Cristae formation R-HSA-8949613 1.497348e-01 0.825 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.725475e-01 0.763 0 0
Translesion synthesis by POLK R-HSA-5655862 2.336551e-01 0.631 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.675023e-01 0.776 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.759939e-01 0.559 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.759939e-01 0.559 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.759939e-01 0.559 0 0
G-protein beta:gamma signalling R-HSA-397795 1.620645e-01 0.790 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.243121e-01 0.649 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.243121e-01 0.649 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.453884e-01 0.837 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.453884e-01 0.837 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.587560e-01 0.799 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.524578e-01 0.817 0 0
GPER1 signaling R-HSA-9634597 1.727253e-01 0.763 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.754661e-01 0.560 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.605344e-01 0.584 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.843773e-01 0.734 0 0
Dual incision in TC-NER R-HSA-6782135 2.381497e-01 0.623 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.243121e-01 0.649 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.685010e-01 0.571 0 0
COPII-mediated vesicle transport R-HSA-204005 1.685535e-01 0.773 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.243121e-01 0.649 0 0
Signaling by MET R-HSA-6806834 1.544600e-01 0.811 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.241707e-01 0.649 0 0
DNA Damage Bypass R-HSA-73893 2.822721e-01 0.549 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.495165e-01 0.603 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.968509e-01 0.706 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.960408e-01 0.708 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.930258e-01 0.714 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.605344e-01 0.584 0 0
G1 Phase R-HSA-69236 1.960408e-01 0.708 0 0
Cyclin D associated events in G1 R-HSA-69231 1.960408e-01 0.708 0 0
Adipogenesis R-HSA-9843745 1.693539e-01 0.771 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.759939e-01 0.559 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.546694e-01 0.811 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.475110e-01 0.606 0 0
DCC mediated attractive signaling R-HSA-418885 1.791976e-01 0.747 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.932530e-01 0.714 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.058276e-01 0.686 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.190910e-01 0.659 0 0
Synthesis of DNA R-HSA-69239 1.789796e-01 0.747 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.544600e-01 0.811 0 0
Translesion synthesis by REV1 R-HSA-110312 1.791976e-01 0.747 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.000056e-01 0.699 0 0
Signaling by Leptin R-HSA-2586552 1.483256e-01 0.829 0 0
Neurexins and neuroligins R-HSA-6794361 1.524578e-01 0.817 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.539804e-01 0.813 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.259744e-01 0.646 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.678263e-01 0.775 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.411102e-01 0.618 0 0
Dopamine receptors R-HSA-390651 2.411102e-01 0.618 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.421383e-01 0.616 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.675023e-01 0.776 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.759939e-01 0.559 0 0
Formation of axial mesoderm R-HSA-9796292 2.759939e-01 0.559 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 2.243121e-01 0.649 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.122954e-01 0.673 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.889709e-01 0.724 0 0
PLC beta mediated events R-HSA-112043 2.868380e-01 0.542 0 0
UCH proteinases R-HSA-5689603 1.726429e-01 0.763 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.421383e-01 0.616 0 0
Mitophagy R-HSA-5205647 1.968509e-01 0.706 0 0
Translation R-HSA-72766 2.601853e-01 0.585 0 0
Protein methylation R-HSA-8876725 1.791976e-01 0.747 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.546694e-01 0.811 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.508957e-01 0.821 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.218299e-01 0.654 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.400191e-01 0.620 0 0
Signaling by TGFB family members R-HSA-9006936 1.831861e-01 0.737 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.528690e-01 0.816 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.546694e-01 0.811 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.421383e-01 0.616 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.893028e-01 0.539 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.843209e-01 0.546 0 0
CHL1 interactions R-HSA-447041 2.067889e-01 0.684 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.791976e-01 0.747 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.791976e-01 0.747 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.336551e-01 0.631 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.540203e-01 0.595 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.520243e-01 0.818 0 0
Neuronal System R-HSA-112316 2.021106e-01 0.694 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.725475e-01 0.763 0 0
Pyroptosis R-HSA-5620971 1.675023e-01 0.776 0 0
Signal attenuation R-HSA-74749 1.483256e-01 0.829 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.968509e-01 0.706 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.463813e-01 0.608 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.788750e-01 0.555 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.654680e-01 0.781 0 0
Signaling by FGFR4 R-HSA-5654743 2.788750e-01 0.555 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.620645e-01 0.790 0 0
HATs acetylate histones R-HSA-3214847 1.480609e-01 0.830 0 0
Inhibition of PKR R-HSA-169131 2.682992e-01 0.571 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.779399e-01 0.750 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.546694e-01 0.811 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.843209e-01 0.546 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.675537e-01 0.573 0 0
rRNA processing R-HSA-72312 2.482446e-01 0.605 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.767447e-01 0.753 0 0
HCMV Late Events R-HSA-9610379 2.079997e-01 0.682 0 0
Potential therapeutics for SARS R-HSA-9679191 1.986059e-01 0.702 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.528690e-01 0.816 0 0
FLT3 signaling in disease R-HSA-9682385 2.344680e-01 0.630 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.791976e-01 0.747 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.624578e-01 0.581 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.641245e-01 0.578 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.740754e-01 0.562 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.497348e-01 0.825 0 0
Signaling by ERBB4 R-HSA-1236394 1.503806e-01 0.823 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.093327e-01 0.679 0 0
OAS antiviral response R-HSA-8983711 2.421383e-01 0.616 0 0
Apoptotic factor-mediated response R-HSA-111471 1.546694e-01 0.811 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.868380e-01 0.542 0 0
Signal transduction by L1 R-HSA-445144 2.000056e-01 0.699 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.243121e-01 0.649 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.373530e-01 0.625 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.421383e-01 0.616 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.421383e-01 0.616 0 0
G1/S-Specific Transcription R-HSA-69205 2.344680e-01 0.630 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.759939e-01 0.559 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.340692e-01 0.631 0 0
Other interleukin signaling R-HSA-449836 1.767447e-01 0.753 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.483256e-01 0.829 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.968509e-01 0.706 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.243121e-01 0.649 0 0
Inositol phosphate metabolism R-HSA-1483249 2.316258e-01 0.635 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.093327e-01 0.679 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.146124e-01 0.668 0 0
Selenoamino acid metabolism R-HSA-2408522 1.682755e-01 0.774 0 0
Ca2+ pathway R-HSA-4086398 2.894117e-01 0.538 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.920126e-01 0.535 0 0
PKA activation R-HSA-163615 2.920126e-01 0.535 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.920126e-01 0.535 0 0
GAB1 signalosome R-HSA-180292 2.920126e-01 0.535 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.920126e-01 0.535 0 0
Platelet sensitization by LDL R-HSA-432142 2.920126e-01 0.535 0 0
RAS processing R-HSA-9648002 2.950882e-01 0.530 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.950882e-01 0.530 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.985148e-01 0.525 0 0
IRS activation R-HSA-74713 2.985148e-01 0.525 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.985148e-01 0.525 0 0
Suppression of autophagy R-HSA-9636569 2.985148e-01 0.525 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.985148e-01 0.525 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.985148e-01 0.525 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.985148e-01 0.525 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.985148e-01 0.525 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.985148e-01 0.525 0 0
Co-inhibition by BTLA R-HSA-9927353 2.985148e-01 0.525 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.985148e-01 0.525 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.025018e-01 0.519 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.058037e-01 0.515 0 0
Platelet calcium homeostasis R-HSA-418360 3.085978e-01 0.511 0 0
Regulation of KIT signaling R-HSA-1433559 3.105491e-01 0.508 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 3.105491e-01 0.508 0 0
Signal regulatory protein family interactions R-HSA-391160 3.105491e-01 0.508 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.105491e-01 0.508 0 0
Non-canonical inflammasome activation R-HSA-9686114 3.105491e-01 0.508 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.108969e-01 0.507 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.160093e-01 0.500 0 0
Signaling by FGFR3 R-HSA-5654741 3.182154e-01 0.497 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.221001e-01 0.492 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.221001e-01 0.492 0 0
The NLRP3 inflammasome R-HSA-844456 3.221001e-01 0.492 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.315457e-01 0.479 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 3.315457e-01 0.479 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.315457e-01 0.479 0 0
Regulation of CDH11 function R-HSA-9762292 3.315457e-01 0.479 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.315457e-01 0.479 0 0
CASP4 inflammasome assembly R-HSA-9948001 3.315457e-01 0.479 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.358993e-01 0.474 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.374819e-01 0.472 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.383275e-01 0.471 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.383275e-01 0.471 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.385742e-01 0.470 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.386452e-01 0.470 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.386452e-01 0.470 0 0
Opioid Signalling R-HSA-111885 3.452937e-01 0.462 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.454738e-01 0.462 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.454738e-01 0.462 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.454738e-01 0.462 0 0
p38MAPK events R-HSA-171007 3.454738e-01 0.462 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.454738e-01 0.462 0 0
Ion channel transport R-HSA-983712 3.517428e-01 0.454 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.525083e-01 0.453 0 0
Formation of definitive endoderm R-HSA-9823730 3.525083e-01 0.453 0 0
Signaling by NODAL R-HSA-1181150 3.525083e-01 0.453 0 0
Protein hydroxylation R-HSA-9629569 3.525083e-01 0.453 0 0
Glycogen synthesis R-HSA-3322077 3.525083e-01 0.453 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.551918e-01 0.450 0 0
Pentose phosphate pathway disease R-HSA-6791465 3.551918e-01 0.450 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.551918e-01 0.450 0 0
Cam-PDE 1 activation R-HSA-111957 3.551918e-01 0.450 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.551918e-01 0.450 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.551918e-01 0.450 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.551918e-01 0.450 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.551918e-01 0.450 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.551918e-01 0.450 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.551918e-01 0.450 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.551918e-01 0.450 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.551918e-01 0.450 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.551918e-01 0.450 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.551918e-01 0.450 0 0
TGFBR3 expression R-HSA-9839394 3.562499e-01 0.448 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.579104e-01 0.446 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.579104e-01 0.446 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.586537e-01 0.445 0 0
HSF1 activation R-HSA-3371511 3.589705e-01 0.445 0 0
GPVI-mediated activation cascade R-HSA-114604 3.589705e-01 0.445 0 0
Immune System R-HSA-168256 3.684352e-01 0.434 0 0
Toll-like Receptor Cascades R-HSA-168898 3.725958e-01 0.429 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.736991e-01 0.427 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.736991e-01 0.427 0 0
Signaling by APC mutants R-HSA-4839744 3.736991e-01 0.427 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.736991e-01 0.427 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.736991e-01 0.427 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.736991e-01 0.427 0 0
LGI-ADAM interactions R-HSA-5682910 3.736991e-01 0.427 0 0
Bicarbonate transporters R-HSA-425381 3.736991e-01 0.427 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.736991e-01 0.427 0 0
Suppression of apoptosis R-HSA-9635465 3.736991e-01 0.427 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.741158e-01 0.427 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.741158e-01 0.427 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.741158e-01 0.427 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.741158e-01 0.427 0 0
Defective GALE causes EDG R-HSA-5609977 3.741158e-01 0.427 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.741158e-01 0.427 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.741158e-01 0.427 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.741158e-01 0.427 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.741158e-01 0.427 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.741158e-01 0.427 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.741158e-01 0.427 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.741158e-01 0.427 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.741158e-01 0.427 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.741158e-01 0.427 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.741158e-01 0.427 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.741158e-01 0.427 0 0
Intestinal infectious diseases R-HSA-8942233 3.741158e-01 0.427 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.741158e-01 0.427 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.741158e-01 0.427 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.741158e-01 0.427 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.741158e-01 0.427 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.741158e-01 0.427 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 3.741158e-01 0.427 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.741158e-01 0.427 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.741158e-01 0.427 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.773274e-01 0.423 0 0
Co-stimulation by CD28 R-HSA-389356 3.791339e-01 0.421 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 3.804631e-01 0.420 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.804631e-01 0.420 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.804631e-01 0.420 0 0
Activation of SMO R-HSA-5635838 3.804631e-01 0.420 0 0
Regulation of BACH1 activity R-HSA-9708530 3.804631e-01 0.420 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.807851e-01 0.419 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.830362e-01 0.417 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.830362e-01 0.417 0 0
Basigin interactions R-HSA-210991 3.830362e-01 0.417 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.832325e-01 0.417 0 0
TRP channels R-HSA-3295583 3.836575e-01 0.416 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.836575e-01 0.416 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.901938e-01 0.409 0 0
Signaling by SCF-KIT R-HSA-1433557 4.025994e-01 0.395 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.081272e-01 0.389 0 0
Integrin signaling R-HSA-354192 4.083445e-01 0.389 0 0
Nuclear RNA decay R-HSA-9930044 4.083445e-01 0.389 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.083445e-01 0.389 0 0
STAT5 Activation R-HSA-9645135 4.101515e-01 0.387 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.101515e-01 0.387 0 0
CREB phosphorylation R-HSA-199920 4.101515e-01 0.387 0 0
Leukotriene receptors R-HSA-391906 4.101515e-01 0.387 0 0
Nef and signal transduction R-HSA-164944 4.101515e-01 0.387 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.110694e-01 0.386 0 0
Insulin processing R-HSA-264876 4.110694e-01 0.386 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.134958e-01 0.384 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.134958e-01 0.384 0 0
Assembly Of The HIV Virion R-HSA-175474 4.134958e-01 0.384 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 4.152410e-01 0.382 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.152410e-01 0.382 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.152410e-01 0.382 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.152410e-01 0.382 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.152410e-01 0.382 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.153021e-01 0.382 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.153021e-01 0.382 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.153021e-01 0.382 0 0
Signaling by AXIN mutants R-HSA-4839735 4.153021e-01 0.382 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.153021e-01 0.382 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 4.164151e-01 0.380 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.189577e-01 0.378 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 4.228894e-01 0.374 0 0
Proteasome assembly R-HSA-9907900 4.244301e-01 0.372 0 0
Netrin-1 signaling R-HSA-373752 4.244301e-01 0.372 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.270175e-01 0.370 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 4.287758e-01 0.368 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.333997e-01 0.363 0 0
Inflammasomes R-HSA-622312 4.383558e-01 0.358 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.495622e-01 0.347 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.495622e-01 0.347 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.495622e-01 0.347 0 0
Glycogen storage diseases R-HSA-3229121 4.495622e-01 0.347 0 0
Attenuation phase R-HSA-3371568 4.519672e-01 0.345 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.519672e-01 0.345 0 0
Polymerase switching R-HSA-69091 4.559717e-01 0.341 0 0
Leading Strand Synthesis R-HSA-69109 4.559717e-01 0.341 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.559717e-01 0.341 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.559717e-01 0.341 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.559717e-01 0.341 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.559717e-01 0.341 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.559717e-01 0.341 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.559717e-01 0.341 0 0
Signaling by LTK R-HSA-9842663 4.559717e-01 0.341 0 0
Mitochondrial protein degradation R-HSA-9837999 4.582041e-01 0.339 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.583021e-01 0.339 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.583021e-01 0.339 0 0
Signal amplification R-HSA-392518 4.583021e-01 0.339 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.627055e-01 0.335 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 4.627055e-01 0.335 0 0
SOS-mediated signalling R-HSA-112412 4.627055e-01 0.335 0 0
Recycling of eIF2:GDP R-HSA-72731 4.627055e-01 0.335 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 4.627055e-01 0.335 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 4.627055e-01 0.335 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.627055e-01 0.335 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.627055e-01 0.335 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.627055e-01 0.335 0 0
ER-Phagosome pathway R-HSA-1236974 4.633027e-01 0.334 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.646347e-01 0.333 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.646347e-01 0.333 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 4.646347e-01 0.333 0 0
Defective visual phototransduction due to ABCA4 loss of function R-HSA-9918454 4.646347e-01 0.333 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.646347e-01 0.333 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.646347e-01 0.333 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.646347e-01 0.333 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.653961e-01 0.332 0 0
Glucagon-type ligand receptors R-HSA-420092 4.653961e-01 0.332 0 0
Post-translational protein modification R-HSA-597592 4.676299e-01 0.330 0 0
Signaling by TGFBR3 R-HSA-9839373 4.678799e-01 0.330 0 0
ABC-family proteins mediated transport R-HSA-382556 4.684249e-01 0.329 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.735351e-01 0.325 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.735351e-01 0.325 0 0
Formation of the ureteric bud R-HSA-9830674 4.735351e-01 0.325 0 0
Syndecan interactions R-HSA-3000170 4.735351e-01 0.325 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.737011e-01 0.324 0 0
ABC transporter disorders R-HSA-5619084 4.744267e-01 0.324 0 0
PERK regulates gene expression R-HSA-381042 4.829620e-01 0.316 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.832130e-01 0.316 0 0
PKA activation in glucagon signalling R-HSA-164378 4.832130e-01 0.316 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.832130e-01 0.316 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.832130e-01 0.316 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.920801e-01 0.308 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.920801e-01 0.308 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.920801e-01 0.308 0 0
Activation of BH3-only proteins R-HSA-114452 4.920801e-01 0.308 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.953979e-01 0.305 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.953979e-01 0.305 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.953979e-01 0.305 0 0
Processing of SMDT1 R-HSA-8949664 4.953979e-01 0.305 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 4.953979e-01 0.305 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.953979e-01 0.305 0 0
Maturation of nucleoprotein R-HSA-9683610 4.953979e-01 0.305 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.028184e-01 0.299 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.028184e-01 0.299 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.028184e-01 0.299 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.071009e-01 0.295 0 0
Signaling by FGFR2 R-HSA-5654738 5.084118e-01 0.294 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 5.124003e-01 0.290 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 5.124003e-01 0.290 0 0
Interleukin-23 signaling R-HSA-9020933 5.124003e-01 0.290 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 5.124003e-01 0.290 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.124003e-01 0.290 0 0
TGFBR3 PTM regulation R-HSA-9839383 5.124003e-01 0.290 0 0
Maturation of nucleoprotein R-HSA-9694631 5.160110e-01 0.287 0 0
Activation of GABAB receptors R-HSA-991365 5.202699e-01 0.284 0 0
GABA B receptor activation R-HSA-977444 5.202699e-01 0.284 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.202699e-01 0.284 0 0
G alpha (z) signalling events R-HSA-418597 5.220413e-01 0.282 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.223490e-01 0.282 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.314417e-01 0.275 0 0
HDMs demethylate histones R-HSA-3214842 5.314417e-01 0.275 0 0
Interleukin-7 signaling R-HSA-1266695 5.314417e-01 0.275 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.323025e-01 0.274 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.331086e-01 0.273 0 0
Prolactin receptor signaling R-HSA-1170546 5.333380e-01 0.273 0 0
cGMP effects R-HSA-418457 5.333380e-01 0.273 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.333380e-01 0.273 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.333380e-01 0.273 0 0
HDL assembly R-HSA-8963896 5.333380e-01 0.273 0 0
Signaling by FGFR1 R-HSA-5654736 5.417745e-01 0.266 0 0
The NLRP1 inflammasome R-HSA-844455 5.420667e-01 0.266 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.420667e-01 0.266 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.420667e-01 0.266 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.420667e-01 0.266 0 0
Defective ABCC2 causes DJS R-HSA-5679001 5.420667e-01 0.266 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 5.420667e-01 0.266 0 0
Defective ABCA1 causes TGD R-HSA-5682113 5.420667e-01 0.266 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.420667e-01 0.266 0 0
Inhibition of nitric oxide production R-HSA-9636249 5.420667e-01 0.266 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 5.420667e-01 0.266 0 0
MET activates STAT3 R-HSA-8875791 5.420667e-01 0.266 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.420667e-01 0.266 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.420667e-01 0.266 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.420667e-01 0.266 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.439903e-01 0.264 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.478042e-01 0.261 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 5.478042e-01 0.261 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.589638e-01 0.253 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.589638e-01 0.253 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.589638e-01 0.253 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 5.589638e-01 0.253 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.589638e-01 0.253 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 5.589638e-01 0.253 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.589638e-01 0.253 0 0
Calcineurin activates NFAT R-HSA-2025928 5.589638e-01 0.253 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.589638e-01 0.253 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.589638e-01 0.253 0 0
Unwinding of DNA R-HSA-176974 5.589638e-01 0.253 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.589638e-01 0.253 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.589638e-01 0.253 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.589638e-01 0.253 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.589638e-01 0.253 0 0
Interleukin-1 processing R-HSA-448706 5.589638e-01 0.253 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.592995e-01 0.252 0 0
RMTs methylate histone arginines R-HSA-3214858 5.641112e-01 0.249 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.690492e-01 0.245 0 0
Erythropoietin activates RAS R-HSA-9027284 5.696094e-01 0.244 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.696094e-01 0.244 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.696094e-01 0.244 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.696094e-01 0.244 0 0
Signaling by Activin R-HSA-1502540 5.696094e-01 0.244 0 0
Platelet homeostasis R-HSA-418346 5.714909e-01 0.243 0 0
Signalling to RAS R-HSA-167044 5.784692e-01 0.238 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.817899e-01 0.235 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.840447e-01 0.234 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.853613e-01 0.233 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 5.863029e-01 0.232 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.999818e-01 0.222 0 0
Glycogen metabolism R-HSA-8982491 5.999818e-01 0.222 0 0
Integration of energy metabolism R-HSA-163685 6.008786e-01 0.221 0 0
Binding and entry of HIV virion R-HSA-173107 6.022621e-01 0.220 0 0
DNA replication initiation R-HSA-68952 6.022621e-01 0.220 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.022621e-01 0.220 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.022621e-01 0.220 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.022621e-01 0.220 0 0
LTC4-CYSLTR mediated IL4 production R-HSA-9664535 6.022621e-01 0.220 0 0
Regulation of the apoptosome activity R-HSA-9627069 6.022621e-01 0.220 0 0
Formation of apoptosome R-HSA-111458 6.022621e-01 0.220 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.040827e-01 0.219 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.040827e-01 0.219 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.040827e-01 0.219 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.079095e-01 0.216 0 0
Cardiac conduction R-HSA-5576891 6.080593e-01 0.216 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 6.083032e-01 0.216 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 6.083032e-01 0.216 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 6.083032e-01 0.216 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 6.083032e-01 0.216 0 0
Defective MAT1A causes MATD R-HSA-5579024 6.083032e-01 0.216 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 6.083032e-01 0.216 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 6.083032e-01 0.216 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 6.083032e-01 0.216 0 0
Signaling by LRP5 mutants R-HSA-5339717 6.083032e-01 0.216 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 6.083032e-01 0.216 0 0
Regulation of gap junction activity R-HSA-191650 6.083032e-01 0.216 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 6.083032e-01 0.216 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 6.083032e-01 0.216 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 6.083032e-01 0.216 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 6.083032e-01 0.216 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 6.083032e-01 0.216 0 0
MDK and PTN in ALK signaling R-HSA-9851151 6.083032e-01 0.216 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 6.083032e-01 0.216 0 0
Sensory perception of sour taste R-HSA-9729555 6.083032e-01 0.216 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.083032e-01 0.216 0 0
Transmission across Electrical Synapses R-HSA-112307 6.083032e-01 0.216 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 6.083032e-01 0.216 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 6.083032e-01 0.216 0 0
Telomere Extension By Telomerase R-HSA-171319 6.123787e-01 0.213 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.185158e-01 0.209 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.217051e-01 0.206 0 0
Kidney development R-HSA-9830369 6.224918e-01 0.206 0 0
Neddylation R-HSA-8951664 6.284994e-01 0.202 0 0
FGFR2 alternative splicing R-HSA-6803529 6.360531e-01 0.197 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.360531e-01 0.197 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.360531e-01 0.197 0 0
Parasitic Infection Pathways R-HSA-9824443 6.364781e-01 0.196 0 0
Leishmania infection R-HSA-9658195 6.364781e-01 0.196 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.366745e-01 0.196 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.366745e-01 0.196 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.366745e-01 0.196 0 0
Galactose catabolism R-HSA-70370 6.366745e-01 0.196 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.366745e-01 0.196 0 0
Pyruvate metabolism R-HSA-70268 6.367291e-01 0.196 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.374691e-01 0.196 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.374691e-01 0.196 0 0
Transcription of the HIV genome R-HSA-167172 6.394522e-01 0.194 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.427613e-01 0.192 0 0
HIV Transcription Initiation R-HSA-167161 6.427613e-01 0.192 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.427613e-01 0.192 0 0
Intra-Golgi traffic R-HSA-6811438 6.427613e-01 0.192 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.427613e-01 0.192 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.427613e-01 0.192 0 0
Translation of Structural Proteins R-HSA-9683701 6.427613e-01 0.192 0 0
FOXO-mediated transcription R-HSA-9614085 6.453474e-01 0.190 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.465416e-01 0.189 0 0
Leishmania phagocytosis R-HSA-9664417 6.487714e-01 0.188 0 0
Parasite infection R-HSA-9664407 6.487714e-01 0.188 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.487714e-01 0.188 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.615300e-01 0.179 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.618548e-01 0.179 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.627366e-01 0.179 0 0
Carnitine shuttle R-HSA-200425 6.628503e-01 0.179 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.631184e-01 0.178 0 0
Activation of AMPA receptors R-HSA-399710 6.649623e-01 0.177 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.649623e-01 0.177 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.649623e-01 0.177 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.649623e-01 0.177 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.649623e-01 0.177 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 6.649623e-01 0.177 0 0
Activation of AKT2 R-HSA-165158 6.649623e-01 0.177 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.649623e-01 0.177 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.649623e-01 0.177 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.649623e-01 0.177 0 0
Inositol transporters R-HSA-429593 6.649623e-01 0.177 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.673406e-01 0.176 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.673406e-01 0.176 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.673406e-01 0.176 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.673406e-01 0.176 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.673406e-01 0.176 0 0
Specification of primordial germ cells R-HSA-9827857 6.673406e-01 0.176 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.776690e-01 0.169 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.790216e-01 0.168 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.790216e-01 0.168 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.790216e-01 0.168 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.790216e-01 0.168 0 0
Sodium/Calcium exchangers R-HSA-425561 6.790216e-01 0.168 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.827515e-01 0.166 0 0
Downstream signal transduction R-HSA-186763 6.845302e-01 0.165 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.882711e-01 0.162 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 6.882711e-01 0.162 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.882711e-01 0.162 0 0
Stimuli-sensing channels R-HSA-2672351 6.884490e-01 0.162 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 6.960697e-01 0.157 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.960697e-01 0.157 0 0
Mismatch Repair R-HSA-5358508 6.960697e-01 0.157 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.960697e-01 0.157 0 0
Tie2 Signaling R-HSA-210993 6.960697e-01 0.157 0 0
Nephron development R-HSA-9831926 6.960697e-01 0.157 0 0
MET promotes cell motility R-HSA-8875878 7.032375e-01 0.153 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.032375e-01 0.153 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.032375e-01 0.153 0 0
DNA strand elongation R-HSA-69190 7.064503e-01 0.151 0 0
Signaling by WNT in cancer R-HSA-4791275 7.064503e-01 0.151 0 0
Tight junction interactions R-HSA-420029 7.123028e-01 0.147 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.123028e-01 0.147 0 0
MET activates RAS signaling R-HSA-8851805 7.126324e-01 0.147 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.126324e-01 0.147 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.126324e-01 0.147 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.126324e-01 0.147 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.126324e-01 0.147 0 0
Plus-strand DNA synthesis R-HSA-164525 7.134285e-01 0.147 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 7.134285e-01 0.147 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 7.134285e-01 0.147 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 7.134285e-01 0.147 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.134285e-01 0.147 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.134285e-01 0.147 0 0
Signaling by RNF43 mutants R-HSA-5340588 7.134285e-01 0.147 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 7.134285e-01 0.147 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 7.134285e-01 0.147 0 0
NGF-independant TRKA activation R-HSA-187024 7.134285e-01 0.147 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 7.134285e-01 0.147 0 0
Phosphorylation of Emi1 R-HSA-176417 7.134285e-01 0.147 0 0
Ceramide signalling R-HSA-193681 7.134285e-01 0.147 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 7.134285e-01 0.147 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.134285e-01 0.147 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 7.134285e-01 0.147 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 7.134285e-01 0.147 0 0
TRAIL signaling R-HSA-75158 7.134285e-01 0.147 0 0
Infectious disease R-HSA-5663205 7.153159e-01 0.146 0 0
Extension of Telomeres R-HSA-180786 7.174820e-01 0.144 0 0
Peroxisomal protein import R-HSA-9033241 7.174820e-01 0.144 0 0
Regulation of beta-cell development R-HSA-186712 7.174820e-01 0.144 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.194073e-01 0.143 0 0
Interferon gamma signaling R-HSA-877300 7.194493e-01 0.143 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.197755e-01 0.143 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.197755e-01 0.143 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.197755e-01 0.143 0 0
Somitogenesis R-HSA-9824272 7.197755e-01 0.143 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.205696e-01 0.142 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.215826e-01 0.142 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.218879e-01 0.142 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.225951e-01 0.141 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.228777e-01 0.141 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.228777e-01 0.141 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.228777e-01 0.141 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.349480e-01 0.134 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.349480e-01 0.134 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.349480e-01 0.134 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.349480e-01 0.134 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.410539e-01 0.130 0 0
HIV Transcription Elongation R-HSA-167169 7.410539e-01 0.130 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.410539e-01 0.130 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.432387e-01 0.129 0 0
Interleukin-6 signaling R-HSA-1059683 7.432387e-01 0.129 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.432387e-01 0.129 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.432387e-01 0.129 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.470244e-01 0.127 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.470244e-01 0.127 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.478021e-01 0.126 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.478021e-01 0.126 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.481314e-01 0.126 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.548859e-01 0.122 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.548859e-01 0.122 0 0
Uncoating of the HIV Virion R-HSA-162585 7.548859e-01 0.122 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 7.548859e-01 0.122 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.548859e-01 0.122 0 0
MET Receptor Activation R-HSA-6806942 7.548859e-01 0.122 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.548859e-01 0.122 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.548859e-01 0.122 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.548859e-01 0.122 0 0
Neurofascin interactions R-HSA-447043 7.548859e-01 0.122 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.548859e-01 0.122 0 0
NADPH regeneration R-HSA-389542 7.548859e-01 0.122 0 0
HDL clearance R-HSA-8964011 7.548859e-01 0.122 0 0
Lipid particle organization R-HSA-8964572 7.548859e-01 0.122 0 0
VLDL assembly R-HSA-8866423 7.548859e-01 0.122 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.562220e-01 0.121 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.562220e-01 0.121 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.562220e-01 0.121 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.562220e-01 0.121 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.617976e-01 0.118 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.625659e-01 0.118 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.656875e-01 0.116 0 0
Calnexin/calreticulin cycle R-HSA-901042 7.656875e-01 0.116 0 0
PI Metabolism R-HSA-1483255 7.689181e-01 0.114 0 0
Lagging Strand Synthesis R-HSA-69186 7.708979e-01 0.113 0 0
G-protein activation R-HSA-202040 7.708979e-01 0.113 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.710062e-01 0.113 0 0
Removal of the Flap Intermediate R-HSA-69166 7.710062e-01 0.113 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.710062e-01 0.113 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.710062e-01 0.113 0 0
Malate-aspartate shuttle R-HSA-9856872 7.710062e-01 0.113 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.710062e-01 0.113 0 0
Translation of Structural Proteins R-HSA-9694635 7.719172e-01 0.112 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.752843e-01 0.111 0 0
HIV elongation arrest and recovery R-HSA-167287 7.761508e-01 0.110 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.761508e-01 0.110 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.761508e-01 0.110 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.764067e-01 0.110 0 0
Insulin receptor signalling cascade R-HSA-74751 7.896566e-01 0.103 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.903479e-01 0.102 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.903479e-01 0.102 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.903479e-01 0.102 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.903479e-01 0.102 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.903479e-01 0.102 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.903479e-01 0.102 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.903479e-01 0.102 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.903479e-01 0.102 0 0
LDL remodeling R-HSA-8964041 7.903479e-01 0.102 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.903479e-01 0.102 0 0
Activation of TRKA receptors R-HSA-187015 7.903479e-01 0.102 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.903479e-01 0.102 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.903479e-01 0.102 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.903479e-01 0.102 0 0
Netrin mediated repulsion signals R-HSA-418886 7.903479e-01 0.102 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.903479e-01 0.102 0 0
Protein localization R-HSA-9609507 7.905740e-01 0.102 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.910740e-01 0.102 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.922333e-01 0.101 0 0
Ribavirin ADME R-HSA-9755088 7.922333e-01 0.101 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.922333e-01 0.101 0 0
Signaling by Erythropoietin R-HSA-9006335 7.947695e-01 0.100 0 0
DARPP-32 events R-HSA-180024 7.947695e-01 0.100 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.961157e-01 0.099 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.961157e-01 0.099 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.961157e-01 0.099 0 0
Biotin transport and metabolism R-HSA-196780 7.961157e-01 0.099 0 0
PI3K Cascade R-HSA-109704 7.989942e-01 0.097 0 0
Triglyceride catabolism R-HSA-163560 7.998445e-01 0.097 0 0
Signaling by FGFR R-HSA-190236 8.015871e-01 0.096 0 0
Developmental Cell Lineages R-HSA-9734767 8.048814e-01 0.094 0 0
PPARA activates gene expression R-HSA-1989781 8.071513e-01 0.093 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.118860e-01 0.091 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.118860e-01 0.091 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.118860e-01 0.091 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.118860e-01 0.091 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.118860e-01 0.091 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.118860e-01 0.091 0 0
Fructose metabolism R-HSA-5652084 8.118860e-01 0.091 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.118860e-01 0.091 0 0
Signaling by KIT in disease R-HSA-9669938 8.118860e-01 0.091 0 0
LDL clearance R-HSA-8964038 8.118860e-01 0.091 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.121203e-01 0.090 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.121203e-01 0.090 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.121203e-01 0.090 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.153873e-01 0.089 0 0
Phosphorylation of the APC/C R-HSA-176412 8.187549e-01 0.087 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 8.187549e-01 0.087 0 0
Atorvastatin ADME R-HSA-9754706 8.187549e-01 0.087 0 0
Fructose catabolism R-HSA-70350 8.187549e-01 0.087 0 0
Reverse Transcription of HIV RNA R-HSA-162589 8.206812e-01 0.086 0 0
Minus-strand DNA synthesis R-HSA-164516 8.206812e-01 0.086 0 0
Type I hemidesmosome assembly R-HSA-446107 8.206812e-01 0.086 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 8.206812e-01 0.086 0 0
DAG1 core M2 glycosylations R-HSA-8932504 8.206812e-01 0.086 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 8.206812e-01 0.086 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 8.206812e-01 0.086 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 8.206812e-01 0.086 0 0
Fructose biosynthesis R-HSA-5652227 8.206812e-01 0.086 0 0
Co-stimulation by ICOS R-HSA-9927354 8.206812e-01 0.086 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 8.206812e-01 0.086 0 0
Nucleotide salvage defects R-HSA-9734207 8.206812e-01 0.086 0 0
phospho-PLA2 pathway R-HSA-111995 8.206812e-01 0.086 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 8.206812e-01 0.086 0 0
tRNA processing R-HSA-72306 8.227690e-01 0.085 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.227864e-01 0.085 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.254541e-01 0.083 0 0
Cargo concentration in the ER R-HSA-5694530 8.282507e-01 0.082 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.299408e-01 0.081 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.299408e-01 0.081 0 0
Interleukin-20 family signaling R-HSA-8854691 8.299408e-01 0.081 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.299466e-01 0.081 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.302536e-01 0.081 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.309981e-01 0.080 0 0
GABA receptor activation R-HSA-977443 8.311247e-01 0.080 0 0
Metabolism of polyamines R-HSA-351202 8.311247e-01 0.080 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.333565e-01 0.079 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.387270e-01 0.076 0 0
Phase 2 - plateau phase R-HSA-5576893 8.391129e-01 0.076 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.391129e-01 0.076 0 0
Fibronectin matrix formation R-HSA-1566977 8.391129e-01 0.076 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.391129e-01 0.076 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.391129e-01 0.076 0 0
Synthesis of PG R-HSA-1483148 8.391129e-01 0.076 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.391129e-01 0.076 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.392220e-01 0.076 0 0
Metabolism of proteins R-HSA-392499 8.423290e-01 0.075 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.423514e-01 0.075 0 0
Pentose phosphate pathway R-HSA-71336 8.435569e-01 0.074 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 8.435569e-01 0.074 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.458020e-01 0.073 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.464866e-01 0.072 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.464866e-01 0.072 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 8.466272e-01 0.072 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.466272e-01 0.072 0 0
WNT mediated activation of DVL R-HSA-201688 8.466272e-01 0.072 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.466272e-01 0.072 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 8.466272e-01 0.072 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.466272e-01 0.072 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.466272e-01 0.072 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.554788e-01 0.068 0 0
Generation of second messenger molecules R-HSA-202433 8.562554e-01 0.067 0 0
Interleukin-2 family signaling R-HSA-451927 8.562554e-01 0.067 0 0
Cardiogenesis R-HSA-9733709 8.570615e-01 0.067 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.570615e-01 0.067 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.573757e-01 0.067 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.573757e-01 0.067 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.573757e-01 0.067 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.573757e-01 0.067 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.573757e-01 0.067 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.573757e-01 0.067 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.616145e-01 0.065 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.616145e-01 0.065 0 0
G protein gated Potassium channels R-HSA-1296059 8.616145e-01 0.065 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.616145e-01 0.065 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.616145e-01 0.065 0 0
Formation of the nephric duct R-HSA-9830364 8.616145e-01 0.065 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.633016e-01 0.064 0 0
RSV-host interactions R-HSA-9833110 8.641811e-01 0.063 0 0
Regulation of insulin secretion R-HSA-422356 8.670245e-01 0.062 0 0
NGF-stimulated transcription R-HSA-9031628 8.684475e-01 0.061 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.688203e-01 0.061 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.688203e-01 0.061 0 0
Interleukin-27 signaling R-HSA-9020956 8.688203e-01 0.061 0 0
Arachidonate production from DAG R-HSA-426048 8.688203e-01 0.061 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.688203e-01 0.061 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.688203e-01 0.061 0 0
Tandem pore domain potassium channels R-HSA-1296346 8.688203e-01 0.061 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.698535e-01 0.061 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.698535e-01 0.061 0 0
Signaling by Insulin receptor R-HSA-74752 8.703194e-01 0.060 0 0
IGF1R signaling cascade R-HSA-2428924 8.725039e-01 0.059 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.737234e-01 0.059 0 0
MET activates PTK2 signaling R-HSA-8874081 8.754161e-01 0.058 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.786896e-01 0.056 0 0
IRS-mediated signalling R-HSA-112399 8.796430e-01 0.056 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.814402e-01 0.055 0 0
eNOS activation R-HSA-203615 8.816467e-01 0.055 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.816467e-01 0.055 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.878031e-01 0.052 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.878031e-01 0.052 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.878031e-01 0.052 0 0
Interleukin-2 signaling R-HSA-9020558 8.878031e-01 0.052 0 0
vRNA Synthesis R-HSA-192814 8.878031e-01 0.052 0 0
vRNP Assembly R-HSA-192905 8.878031e-01 0.052 0 0
Conjugation of benzoate with glycine R-HSA-177135 8.878031e-01 0.052 0 0
Chylomicron assembly R-HSA-8963888 8.878031e-01 0.052 0 0
Synthesis of PI R-HSA-1483226 8.878031e-01 0.052 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.878031e-01 0.052 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.878031e-01 0.052 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.878031e-01 0.052 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.879823e-01 0.052 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.879823e-01 0.052 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.883277e-01 0.051 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.883277e-01 0.051 0 0
Specification of the neural plate border R-HSA-9834899 8.883277e-01 0.051 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.883277e-01 0.051 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.883277e-01 0.051 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.883277e-01 0.051 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.883277e-01 0.051 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.883277e-01 0.051 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.886067e-01 0.051 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.895276e-01 0.051 0 0
Signaling by FGFR in disease R-HSA-1226099 8.916828e-01 0.050 0 0
The phototransduction cascade R-HSA-2514856 8.971674e-01 0.047 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.994017e-01 0.046 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.994017e-01 0.046 0 0
Insulin receptor recycling R-HSA-77387 8.994017e-01 0.046 0 0
Pregnenolone biosynthesis R-HSA-196108 9.013508e-01 0.045 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.013508e-01 0.045 0 0
Creatine metabolism R-HSA-71288 9.013508e-01 0.045 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.024681e-01 0.045 0 0
RNA Polymerase III Transcription R-HSA-74158 9.024681e-01 0.045 0 0
Neurotransmitter release cycle R-HSA-112310 9.030172e-01 0.044 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 9.040399e-01 0.044 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 9.040399e-01 0.044 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 9.040399e-01 0.044 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 9.040399e-01 0.044 0 0
Activation of RAC1 R-HSA-428540 9.040399e-01 0.044 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 9.040399e-01 0.044 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.046949e-01 0.043 0 0
tRNA Aminoacylation R-HSA-379724 9.048551e-01 0.043 0 0
Gastrulation R-HSA-9758941 9.069616e-01 0.042 0 0
mRNA Capping R-HSA-72086 9.097606e-01 0.041 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.097606e-01 0.041 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.097606e-01 0.041 0 0
Aquaporin-mediated transport R-HSA-445717 9.121905e-01 0.040 0 0
Abacavir metabolism R-HSA-2161541 9.129443e-01 0.040 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.131803e-01 0.039 0 0
IRE1alpha activates chaperones R-HSA-381070 9.152512e-01 0.038 0 0
Scavenging by Class F Receptors R-HSA-3000484 9.179278e-01 0.037 0 0
Interleukin-35 Signalling R-HSA-8984722 9.179278e-01 0.037 0 0
GRB2 events in EGFR signaling R-HSA-179812 9.179278e-01 0.037 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.179278e-01 0.037 0 0
Conjugation of salicylate with glycine R-HSA-177128 9.179278e-01 0.037 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.179278e-01 0.037 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 9.179278e-01 0.037 0 0
Estrogen biosynthesis R-HSA-193144 9.179278e-01 0.037 0 0
Interleukin-15 signaling R-HSA-8983432 9.179278e-01 0.037 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.179278e-01 0.037 0 0
Mitochondrial protein import R-HSA-1268020 9.190337e-01 0.037 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.191414e-01 0.037 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.191414e-01 0.037 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.208635e-01 0.036 0 0
SLC transporter disorders R-HSA-5619102 9.217469e-01 0.035 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.229968e-01 0.035 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.229968e-01 0.035 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.232493e-01 0.035 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.252949e-01 0.034 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.276230e-01 0.033 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.276230e-01 0.033 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.276341e-01 0.033 0 0
Acetylcholine binding and downstream events R-HSA-181431 9.298064e-01 0.032 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.298064e-01 0.032 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 9.298064e-01 0.032 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.298064e-01 0.032 0 0
Chylomicron remodeling R-HSA-8963901 9.298064e-01 0.032 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.298064e-01 0.032 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.298064e-01 0.032 0 0
CD28 dependent Vav1 pathway R-HSA-389359 9.298064e-01 0.032 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.298064e-01 0.032 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.323957e-01 0.030 0 0
Ethanol oxidation R-HSA-71384 9.323957e-01 0.030 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.323957e-01 0.030 0 0
Diseases of Immune System R-HSA-5260271 9.346202e-01 0.029 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.346202e-01 0.029 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.352800e-01 0.029 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.352800e-01 0.029 0 0
Gluconeogenesis R-HSA-70263 9.361659e-01 0.029 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 9.399663e-01 0.027 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 9.399663e-01 0.027 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 9.399663e-01 0.027 0 0
Physiological factors R-HSA-5578768 9.399663e-01 0.027 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.399663e-01 0.027 0 0
Zinc transporters R-HSA-435354 9.399663e-01 0.027 0 0
P2Y receptors R-HSA-417957 9.399663e-01 0.027 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.405030e-01 0.027 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.405030e-01 0.027 0 0
Biosynthesis of maresins R-HSA-9018682 9.405030e-01 0.027 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.405030e-01 0.027 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.421826e-01 0.026 0 0
Iron uptake and transport R-HSA-917937 9.453647e-01 0.024 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.467867e-01 0.024 0 0
Azathioprine ADME R-HSA-9748787 9.472776e-01 0.024 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.476803e-01 0.023 0 0
Interleukin-6 family signaling R-HSA-6783589 9.476803e-01 0.023 0 0
Complex III assembly R-HSA-9865881 9.476803e-01 0.023 0 0
Heme degradation R-HSA-189483 9.483967e-01 0.023 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.486562e-01 0.023 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.486562e-01 0.023 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.486562e-01 0.023 0 0
Protein lipoylation R-HSA-9857492 9.486562e-01 0.023 0 0
Protein repair R-HSA-5676934 9.486562e-01 0.023 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.486562e-01 0.023 0 0
Other semaphorin interactions R-HSA-416700 9.486562e-01 0.023 0 0
DNA Damage Reversal R-HSA-73942 9.486562e-01 0.023 0 0
Triglyceride metabolism R-HSA-8979227 9.489004e-01 0.023 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.540270e-01 0.020 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.540270e-01 0.020 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.540270e-01 0.020 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.540270e-01 0.020 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.560887e-01 0.020 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.560887e-01 0.020 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.560887e-01 0.020 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.560887e-01 0.020 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.560887e-01 0.020 0 0
Killing mechanisms R-HSA-9664420 9.560887e-01 0.020 0 0
Attachment and Entry R-HSA-9678110 9.560887e-01 0.020 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.590010e-01 0.018 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.590010e-01 0.018 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.590010e-01 0.018 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.596331e-01 0.018 0 0
Urea cycle R-HSA-70635 9.596331e-01 0.018 0 0
Abacavir ADME R-HSA-2161522 9.596331e-01 0.018 0 0
Sphingolipid catabolism R-HSA-9845614 9.596331e-01 0.018 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 9.596331e-01 0.018 0 0
G alpha (s) signalling events R-HSA-418555 9.609590e-01 0.017 0 0
Signaling by PDGF R-HSA-186797 9.612444e-01 0.017 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.620590e-01 0.017 0 0
Glycine degradation R-HSA-6783984 9.624456e-01 0.017 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 9.624456e-01 0.017 0 0
Heme assimilation R-HSA-9927020 9.624456e-01 0.017 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.624456e-01 0.017 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.624456e-01 0.017 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.624456e-01 0.017 0 0
Interferon alpha/beta signaling R-HSA-909733 9.640536e-01 0.016 0 0
Signaling by BMP R-HSA-201451 9.645799e-01 0.016 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.645799e-01 0.016 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.645799e-01 0.016 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.645799e-01 0.016 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.656444e-01 0.015 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.670023e-01 0.015 0 0
Voltage gated Potassium channels R-HSA-1296072 9.675328e-01 0.014 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.678825e-01 0.014 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.685999e-01 0.014 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.689408e-01 0.014 0 0
Elastic fibre formation R-HSA-1566948 9.711411e-01 0.013 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.725326e-01 0.012 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.725326e-01 0.012 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.725326e-01 0.012 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.727817e-01 0.012 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.734816e-01 0.012 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.743672e-01 0.011 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.743672e-01 0.011 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.759251e-01 0.011 0 0
DAP12 signaling R-HSA-2424491 9.761618e-01 0.010 0 0
Neurotransmitter clearance R-HSA-112311 9.761618e-01 0.010 0 0
Pyrimidine biosynthesis R-HSA-500753 9.765097e-01 0.010 0 0
Conjugation of carboxylic acids R-HSA-159424 9.765097e-01 0.010 0 0
Amino Acid conjugation R-HSA-156587 9.765097e-01 0.010 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.765097e-01 0.010 0 0
Tryptophan catabolism R-HSA-71240 9.772488e-01 0.010 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.785931e-01 0.009 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.797918e-01 0.009 0 0
Maturation of spike protein R-HSA-9694548 9.798201e-01 0.009 0 0
Melanin biosynthesis R-HSA-5662702 9.799111e-01 0.009 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.799111e-01 0.009 0 0
Innate Immune System R-HSA-168249 9.809283e-01 0.008 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.809391e-01 0.008 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.820596e-01 0.008 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.828201e-01 0.008 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.828201e-01 0.008 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.828201e-01 0.008 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.828201e-01 0.008 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.828201e-01 0.008 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.828201e-01 0.008 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.841548e-01 0.007 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.853080e-01 0.006 0 0
Serine metabolism R-HSA-977347 9.853080e-01 0.006 0 0
Attachment and Entry R-HSA-9694614 9.853080e-01 0.006 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.860501e-01 0.006 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.860501e-01 0.006 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.864497e-01 0.006 0 0
Disease R-HSA-1643685 9.870834e-01 0.006 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.873976e-01 0.006 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.873976e-01 0.006 0 0
DAP12 interactions R-HSA-2172127 9.875889e-01 0.005 0 0
Hyaluronan metabolism R-HSA-2142845 9.878141e-01 0.005 0 0
RA biosynthesis pathway R-HSA-5365859 9.878141e-01 0.005 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.879158e-01 0.005 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.891516e-01 0.005 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.892555e-01 0.005 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.892555e-01 0.005 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.892555e-01 0.005 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.893599e-01 0.005 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.893599e-01 0.005 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.893599e-01 0.005 0 0
Glycosphingolipid transport R-HSA-9845576 9.907137e-01 0.004 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.907137e-01 0.004 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.907137e-01 0.004 0 0
CYP2E1 reactions R-HSA-211999 9.908118e-01 0.004 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.908118e-01 0.004 0 0
Synthesis of PA R-HSA-1483166 9.908517e-01 0.004 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.916796e-01 0.004 0 0
Laminin interactions R-HSA-3000157 9.921427e-01 0.003 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.921427e-01 0.003 0 0
Hyaluronan degradation R-HSA-2160916 9.921427e-01 0.003 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.921427e-01 0.003 0 0
Retinoid cycle disease events R-HSA-2453864 9.921427e-01 0.003 0 0
Diseases associated with visual transduction R-HSA-2474795 9.921427e-01 0.003 0 0
Diseases of the neuronal system R-HSA-9675143 9.921427e-01 0.003 0 0
Metal ion SLC transporters R-HSA-425410 9.924370e-01 0.003 0 0
Purine salvage R-HSA-74217 9.929351e-01 0.003 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.932809e-01 0.003 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.932809e-01 0.003 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.933266e-01 0.003 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.935436e-01 0.003 0 0
ECM proteoglycans R-HSA-3000178 9.940932e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.940932e-01 0.003 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.942543e-01 0.003 0 0
Triglyceride biosynthesis R-HSA-75109 9.942543e-01 0.003 0 0
Synthesis of PE R-HSA-1483213 9.942543e-01 0.003 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.946335e-01 0.002 0 0
Phosphate bond hydrolysis by NTPDase proteins R-HSA-8850843 9.950867e-01 0.002 0 0
Prednisone ADME R-HSA-9757110 9.950867e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.953254e-01 0.002 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.957985e-01 0.002 0 0
Nucleotide biosynthesis R-HSA-8956320 9.959739e-01 0.002 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.962950e-01 0.002 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.969167e-01 0.001 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.969279e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.973127e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.973127e-01 0.001 0 0
Methylation R-HSA-156581 9.973177e-01 0.001 0 0
Amine ligand-binding receptors R-HSA-375280 9.973177e-01 0.001 0 0
DAG1 glycosylations R-HSA-8931838 9.973731e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.975565e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.976674e-01 0.001 0 0
Recycling of bile acids and salts R-HSA-159418 9.977537e-01 0.001 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.980793e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.981088e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.982373e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.982681e-01 0.001 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.983577e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.983644e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.984684e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.984880e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.985957e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.986443e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.986695e-01 0.001 0 0
HS-GAG biosynthesis R-HSA-2022928 9.987993e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.988013e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.988445e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.989733e-01 0.000 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.989733e-01 0.000 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.989733e-01 0.000 0 0
Metabolism of folate and pterines R-HSA-196757 9.989733e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.989968e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.990003e-01 0.000 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.991221e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.993473e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.993473e-01 0.000 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.993582e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.994260e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.994312e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.994513e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.995309e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.995309e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.995723e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.996854e-01 0.000 0 0
Surfactant metabolism R-HSA-5683826 9.997068e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.997215e-01 0.000 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.997493e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.997587e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.997655e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.997763e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.998102e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.998190e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.998433e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.998433e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.998557e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998584e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.998884e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.999021e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.999120e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999250e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999431e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999447e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999508e-01 0.000 0 0
Digestion R-HSA-8935690 9.999553e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999619e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999721e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999721e-01 0.000 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.999721e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999795e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999796e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.999796e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999823e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999846e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999851e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999868e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.999874e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999879e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999890e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999902e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999915e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.999920e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999926e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999955e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999958e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999958e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999973e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999973e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999974e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999983e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999983e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999988e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999991e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999992e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999992e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999996e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999998e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999998e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999999e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999999e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 1.000000e+00 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 1.000000e+00 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways