TSSK1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

Log-Odds: S Sites / S Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0JLT2	S239	Sugiyama	MED19 LCMR1	KKKKNRHsPDHPGMGssQAssSSSLR_______________
A0MZ66	S473	Sugiyama	SHTN1 KIAA1598	LGtLNKSTSSRsLKsLDPENsEtELERILRRRKVtAEADss
A4FU28	S138	Sugiyama	CTAGE9	EKAAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKS
A4FU28	S140	Sugiyama	CTAGE9	AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
A6NDS4	T152	Sugiyama	TBC1D3B TBC1D3I	KEKGKRSSEHIQRIDRDISGtLRKHMFFRDRYGTKQRELLH
A6NKT7	S978	Sugiyama	RGPD3 RGP3	GRGVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSG
A6NKT7	S980	Sugiyama	RGPD3 RGP3	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
A6NMY6	S127	Sugiyama	ANXA2P2 ANX2L2 ANX2P2 LPC2B	AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy
B9A6J9	T152	Sugiyama	TBC1D3L PRC17	KEKGKRSSEHIQRIDRDVSGtLRKHIFFRDRYGTKQRELLH
O00151	S84	Sugiyama	PDLIM1 CLIM1 CLP36	LEAQNRIKGCTDNLtLtVARsEHKVWsPLVtEEGKRHPYKM
O00151	T80	Sugiyama	PDLIM1 CLIM1 CLP36	NMTHLEAQNRIKGCTDNLtLtVARsEHKVWsPLVtEEGKRH
O00231	S298	Sugiyama	PSMD11	RYAGRQTEALKCVAQASKNRsLADFEKALTDYRAELRDDPI
O00273	S28	Sugiyama	DFFA DFF1 DFF45 H13	GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O00273	S302	Sugiyama	DFFA DFF1 DFF45 H13	TETVQEACERELALRLQQtQsLHsLRsIsAsKAsPPGDLQN
O00410	S726	Sugiyama	IPO5 KPNB3 RANBP5	LMVPLLKFYFHDGVRVAAAEsMPLLLECARVRGPEYLTQMW
O14715	S977	Sugiyama	RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3	GRGVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSG
O14715	S979	Sugiyama	RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15067	S215	Sugiyama	PFAS KIAA0361	LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15226	S618	Sugiyama	NKRF ITBA4 NRF	VNKIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQ
O15226	T620	Sugiyama	NKRF ITBA4 NRF	KIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQIA
O15355	S349	Sugiyama	PPM1G PPM1C	tTAVVALIRGKQLIVANAGDsRCVVsEAGKALDMsyDHKPE
O43399	S21	Sugiyama	TPD52L2	MDsAGQDINLNsPNKGLLsDsMtDVPVDTGVAARtPAVEGL
O43464	S435	Sugiyama	HTRA2 OMI PRSS25	AIGEQMVQNAEDVYEAVRTQsQLAVQIRRGRETLTLYVTPE
O43815	S229	Sugiyama	STRN	TEAEVKETAMIAKSELtDsAsVLDNFKFLEsAAADFsDEDE
O43823	S124	Sugiyama	AKAP8 AKAP95	SKEGGRGGsGGGGEGIQDREssFRFQPFESYDSRPCLPEHN
O43852	S69	Sugiyama	CALU	HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60291	S515	Sugiyama	MGRN1 KIAA0544 RNF156	sFItEEVDESssPQQGTRAAsIENVLQDssPEHCGRGPPAD
O60333	S1603	Sugiyama	KIF1B KIAA0591 KIAA1448	TKCLQLLTHTFNREFSQVHGsVsDCKLsDIsPIGRDPSESS
O60333	S1605	Sugiyama	KIF1B KIAA0591 KIAA1448	CLQLLTHTFNREFSQVHGsVsDCKLsDIsPIGRDPSESSFS
O60343	T749	Sugiyama	TBC1D4 AS160 KIAA0603	ENEIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRR
O60716	S252	Sugiyama	CTNND1 KIAA0384	sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60763	S245	Sugiyama	USO1 VDP	GGIVVEDCLILLQNLLKNNNsNQNFFKEGSYIQRMKPWFEV
O60763	S32	Sugiyama	USO1 VDP	SAGPQHTEAEtIQKLCDRVAssTLLDDRRNAVRALKSLSKK
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75116	T573	Sugiyama	ROCK2 KIAA0619	STEKVNQLQRQLDEtNALLRtESDTAARLRKTQAESSKQIQ
O75179	S243	Sugiyama	ANKRD17 GTAR KIAA0697	RAEStANAGQSDNRSLAEACsEGDVNAVRKLLIEGRSVNEH
O75390	S453	Sugiyama	CS	LAQLIWSRALGFPLERPKSMsTEGLMKFVDSKSG_______
O75822	S127	Sugiyama	EIF3J EIF3S1 PRO0391	VLtPEEQLADKLRLKKLQEEsDLELAKEtFGVNNAVyGIDA
O75822	S202	Sugiyama	EIF3J EIF3S1 PRO0391	VLVRDVCISLEIDDLKKITNsLTVLCsEKQKQEKQSKAKKK
O76003	S118	Sugiyama	GLRX3 PICOT TXNL2 HUSSY-22	DRLDGAHAPELTKKVQRHAssGsFLPSANEHLKEDLNLRLK
O76003	S120	Sugiyama	GLRX3 PICOT TXNL2 HUSSY-22	LDGAHAPELTKKVQRHAssGsFLPSANEHLKEDLNLRLKKL
O76021	S314	Sugiyama	RSL1D1 CATX11 CSIG PBK1 L12	RNFEKQKERKKKRQQARKtAsVLsKDDVAPEsGDtTVKKPE
O76070	S51	Sugiyama	SNCG BCSG1 PERSYN PRSN	EKTKEGVMyVGAKtKENVVQsVTsVAEKTKEQANAVSEAVV
O95155	S105	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95155	S118	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	QsLsRsQsMDIDGVSCEKsMsQVDVDsGIENMEVDENDRRE
O95197	T318	Sugiyama	RTN3 ASYIP NSPL2	RNKEAGRYPMSALLSRQFsHtNAALEEVSRCVNDMHNFTNE
O95218	S181	Sugiyama	ZRANB2 ZIS ZNF265	DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95817	S184	Sugiyama	BAG3 BIS	AsHGPERsQsPAAsDCsssSsSAsLPssGRssLGsHQLPRG
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00558	S174	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558	S175	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P01023	S593	Sugiyama	A2M CPAMD5 FWP007	SPSQSLPASHAHLRVTAAPQsVCALRAVDQSVLLMKPDAEL
P01130	S286	Sugiyama	LDLR	DEVGCVNVTLCEGPNKFKCHsGECITLDKVCNMARDCRDWS
P02545	S295	Sugiyama	LMNA LMN1	RQsAERNsNLVGAAHEELQQsRIRIDsLsAQLsQLQKQLAA
P02786	S10	Sugiyama	TFRC	___________MMDQARsAFsNLFGGEPLsytRFsLARQVD
P02786	S19	Sugiyama	TFRC	__MMDQARsAFsNLFGGEPLsytRFsLARQVDGDNsHVEMK
P02786	S361	Sugiyama	TFRC	AAEKLFGNMEGDCPSDWKTDstCRMVTSESKNVKLTVSNVL
P04406	S151	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	FVMGVNHEKYDNSLKIIsNAsCttNCLAPLAKVIHDNFGIV
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792	S187	Sugiyama	HSPB1 HSP27 HSP28	APMPKLAtQsNEItIPVtFEsRAQLGGPEAAKsDETAAK__
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05023	S519	Sugiyama	ATP1A1	sEPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQ
P05198	S219	Sugiyama	EIF2S1 EIF2A	CYGYEGIDAVKEALRAGLNCsTENMPIKINLIAPPRYVMTT
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05387	S19	Sugiyama	RPLP2 D11S2243E RPP2	__MRyVAsyLLAALGGNssPsAKDIKKILDsVGIEADDDRL
P05387	S6	Sugiyama	RPLP2 D11S2243E RPP2	_______________MRyVAsyLLAALGGNssPsAKDIKKI
P05387	Y3	Sugiyama	RPLP2 D11S2243E RPP2	__________________MRyVAsyLLAALGGNssPsAKDI
P05387	Y7	Sugiyama	RPLP2 D11S2243E RPP2	______________MRyVAsyLLAALGGNssPsAKDIKKIL
P05388	S307	Sugiyama	RPLP0	AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
P05556	S675	Sugiyama	ITGB1 FNRB MDF2 MSK12	GEKKDTCTQECSYFNITKVEsRDKLPQPVQPDPVsHCKEKD
P05783	S401	Sugiyama	KRT18 CYK18 PIG46	RRLLEDGEDFNLGDALDssNsMQtIQKtTTRRIVDGKVVsE
P05787	S280	Sugiyama	KRT8 CYK8	IAEVKAQyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDL
P06737	S831	Sugiyama	PYGL	KFSSDRTIKEyAQNIWNVEPsDLKIsLSNESNKVNGN____
P06744	S107	Sugiyama	GPI	GEKINyTEGRAVLHVALRNRsNtPILVDGKDVMPEVNKVLD
P06756	S955	Sugiyama	ITGAV MSK8 VNRA VTNR	TETFMNKENQNHSYSLKSSAsFNVIEFPYKNLPIEDITNST
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S320	Sugiyama	LDHB	GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07339	S42	Sugiyama	CTSD CPSD	VRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQAVPAV
P07339	T35	Sugiyama	CTSD CPSD	AAPASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKY
P07355	S127	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy
P07384	S474	Sugiyama	CAPN1 CANPL1 PIG30	GQPAVHLKRDFFLANAsRARsEQFINLREVSTRFRLPPGEY
P07437	S115	Sugiyama	TUBB TUBB5 OK/SW-cl.56	sGAGNNWAKGHytEGAELVDsVLDVVRKEAESCDCLQGFQL
P07602	S29	Sugiyama	PSAP GLBA SAP1	SLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVKHCL
P07814	S335	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07814	S739	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07814	S814	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	KTGQEYKPGNPPAEIGQNIssNssAsILESKsLyDEVAAQG
P07814	S816	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	GQEYKPGNPPAEIGQNIssNssAsILESKsLyDEVAAQGEV
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P08195	S286	Sugiyama	SLC3A2 MDU1	KNQKDDVAQtDLLQIDPNFGsKEDFDsLLQsAKKKSIRVIL
P08195	S518	Sugiyama	SLC3A2 MDU1	DIPGAVSANMTVKGQsEDPGsLLsLFRRLsDQRsKERSLLH
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	S490	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	sEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRKRGFEV
P08238	S532	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	yMtEPIDEyCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKK
P08865	S138	Sugiyama	RPSA LAMBR LAMR1	EPRLLVVTDPRADHQPLtEAsyVNLPtIALCNTDSPLRyVD
P09972	S45	Sugiyama	ALDOC ALDC	APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P0CAP2	S187	Sugiyama	POLR2M GRINL1A	EASEHHPRHRVssQAEDtSssFDNLFIDRLQRITIADQGEQ
P0CG41	S138	Sugiyama	CTAGE8	EKAAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKS
P0CG41	S140	Sugiyama	CTAGE8	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P0CG47	S57	Sugiyama	UBB	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48	S57	Sugiyama	UBC	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0DJD0	S962	Sugiyama	RGPD1 RANBP2L6 RGP1	GRGVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSG
P0DJD0	S964	Sugiyama	RGPD1 RANBP2L6 RGP1	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412	S58	Sugiyama	H1-4 H1F4 HIST1H1E	PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P10809	S410	Sugiyama	HSPD1 HSP60	LNERLAKLsDGVAVLKVGGtsDVEVNEKKDRVtDALNAtRA
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11279	S141	Sugiyama	LAMP1	NLSDTHLFPNASSKEIKtVEsITDIRADIDKKYRCVSGTQV
P11279	T138	Sugiyama	LAMP1	FVYNLSDTHLFPNASSKEIKtVEsITDIRADIDKKYRCVSG
P11586	S318	Sugiyama	MTHFD1 MTHFC MTHFD	FKPGKWMIQYNNLNLKTPVPsDIDIsRSCKPKPIGKLAREI
P11586	S765	Sugiyama	MTHFD1 MTHFC MTHFD	ARMFGIPVVVAVNAFKTDTEsELDLIsRLSREHGAFDAVKC
P12004	S172	Sugiyama	PCNA	sHIGDAVVIsCAKDGVKFSAsGELGNGNIKLSQTSNVDKEE
P12268	S416	Sugiyama	IMPDH2 IMPD2	APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P12270	S909	Sugiyama	TPR	NTKELLKNAQKEIATLKQHLsNMEVQVASQSSQRTGKGQPs
P13073	S89	Sugiyama	COX4I1 COX4	SWssLsMDEKVELYRIKFKEsFAEMNRGSNEWKTVVGGAMF
P13473	S155	Sugiyama	LAMP2	LTVDELLAIRIPLNDLFRCNsLSTLEKNDVVQHYWDVLVQA
P13489	S178	Sugiyama	RNH1 PRI RNH	SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13667	S470	Sugiyama	PDIA4 ERP70 ERP72	FAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAMEP
P13674	S395	Sugiyama	P4HA1 P4HA	TVHYRISKsAWLsGyENPVVsRINMRIQDLTGLDVSTAEEL
P13797	S339	Sugiyama	PLS3	PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV
P13797	S540	Sugiyama	PLS3	NDDIIVNWVNRTLSEAGKSTsIQSFKDKTISSSLAVVDLID
P13798	S187	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	EKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQFV
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625	S514	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14866	S544	Sugiyama	HNRNPL HNRPL P/OKcl.14	LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P14868	S192	Sugiyama	DARS1 DARS PIG40	ATVNQDTRLDNRVIDLRTsTsQAVFRLQSGICHLFRETLIN
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16083	S80	Sugiyama	NQO2 NMOR2	LSNPEVFNyGVEtHEAyKQRsLAsDITDEQKKVREADLVIF
P16333	S85	Sugiyama	NCK1 NCK	ASIVKNLKDTLGIGKVKRKPsVPDsAsPADDsFVDPGERLy
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402	S59	Sugiyama	H1-3 H1F3 HIST1H1D	PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	S58	Sugiyama	H1-2 H1F2 HIST1H1C	PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16949	S16	Sugiyama	STMN1 C1orf215 LAP18 OP18	_____MAssDIQVKELEKRAsGQAFELILsPRsKEsVPEFP
P16949	S46	Sugiyama	STMN1 C1orf215 LAP18 OP18	PRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAEERRKsHEA
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17544	S44	Sugiyama	ATF7 ATFA	LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17987	S374	Sugiyama	TCP1 CCT1 CCTA	ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P18031	S15	Sugiyama	PTPN1 PTP1B	______MEMEKEFEQIDKsGsWAAIyQDIRHEASDFPCRVA
P18669	S152	Sugiyama	PGAM1 PGAMA CDABP0006	FysNIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIV
P18754	S85	Sugiyama	RCC1 CHC1	IPEDVVQAEAGGMHTVCLSKsGQVysFGCNDEGALGRDtsV
P18858	S388	Sugiyama	LIG1	SVRAEAAEKGDVGLVAENSRsTQRLMLPPPPLTASGVFSKF
P18858	S901	Sugiyama	LIG1	DKQPEQATTSAQVACLYRKQsQIQNQQGEDsGsDPEDTY__
P19338	S356	Sugiyama	NCL	LAVVDVRIGMTRKFGyVDFEsAEDLEKALELtGLKVFGNEI
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20674	S104	Sugiyama	COX5A	PEPKIIDAALRACRRLNDFAstVRILEVVKDKAGPHKEIYP
P20700	T544	Sugiyama	LMNB1 LMN2 LMNB	GEDVKVILKNsQGEEVAQRstVFKttIPEEEEEEEEAAGVV
P21108	S10	Sugiyama	PRPS1L1 PRPS3 PRPSL	___________MPNIKIFsGssHQDLSQKIADRLGLELGKV
P21108	S11	Sugiyama	PRPS1L1 PRPS3 PRPSL	__________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P21333	S1029	Sugiyama	FLNA FLN FLN1	VGPSGAAVPCKVEPGLGADNsVVRFLPREEGPYEVEVTYDG
P21333	S2152	Sugiyama	FLNA FLN FLN1	VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P21333	S2158	Sugiyama	FLNA FLN FLN1	GRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQDMtAQV
P22059	S386	Sugiyama	OSBP OSBP1	ITMPENLGHKRtGsNIsGAssDIsLDEQyKHQLEETKKEKR
P22061	S9	Sugiyama	PCMT1	____________MAWKSGGAsHSELIHNLRKNGIIKTDKVF
P22314	S46	Sugiyama	UBA1 A1S9T UBE1	AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23921	S119	Sugiyama	RRM1 RR1	EDLyNyINPHNGKHSPMVAKstLDIVLANKDRLNsAIIYDR
P24534	S141	Sugiyama	EEF1B2 EEF1B EF1B	ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25398	S107	Sugiyama	RPS12	EWVGLCKIDREGKPRKVVGCsCVVVKDYGKESQAKDVIEEy
P25788	S34	Sugiyama	PSMA3 HC8 PSC8	tFsPDGRVFQVEYAMKAVENssTAIGIRCKDGVVFGVEKLV
P26006	S898	Sugiyama	ITGA3 MSK18	DPGGGQGPPPVTLAAAKKAKsETVLTCATGRAHCVWLECPI
P27348	S63	Sugiyama	YWHAQ	LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR
P27816	S440	Sugiyama	MAP4	QANDIISSTEISSAEKVALssETEVALARDMtLPPETNVIL
P29353	S426	Sugiyama	SHC1 SHC SHCA	VRKQMPPPPPCPGRELFDDPsyVNVQNLDKARQAVGGAGPP
P29401	S105	Sugiyama	TKT	VWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGsL
P29401	S332	Sugiyama	TKT	GDKIATRKAYGQALAKLGHAsDRIIALDGDtKNstFsEIFK
P29692	S44	Sugiyama	EEF1D EF1D	RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P30044	S101	Sugiyama	PRDX5 ACR1 SBBI10	LFKGKKGVLFGVPGAFtPGCsKtHLPGFVEQAEALKAKGVQ
P30048	S199	Sugiyama	PRDX3 AOP1	SGLALRGLFIIDPNGVIKHLsVNDLPVGRSVEETLRLVKAF
P30086	S99	Sugiyama	PEBP1 PBP PEBP	PKYREWHHFLVVNMKGNDIssGtVLsDyVGsGPPKGtGLHR
P31153	S38	Sugiyama	MAT2A AMS2 MATA2	FLFTSESVGEGHPDKICDQIsDAVLDAHLQQDPDAKVACET
P31327	S835	Sugiyama	CPS1	MCHPsIEGFTPRLPMNKEWPsNLDLRKELSEPSsTRIyAIA
P31327	S898	Sugiyama	CPS1	LYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQIS
P31939	S450	Sugiyama	ATIC PURH OK/SW-cl.86	SNSVCYAKNGQVIGIGAGQQsRIHCTRLAGDKANyWWLRHH
P31946	S65	Sugiyama	YWHAB	LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR
P33981	S455	Sugiyama	TTK MPS1 MPS1L1	QsPPISTSKWFDPKSICKtPssNtLDDYMsCFRtPVVKNDF
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35221	S652	Sugiyama	CTNNA1	IRtPEELDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAI
P35579	S1304	Sugiyama	MYH9	NVtGLLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQK
P35579	S1808	Sugiyama	MYH9	KELKVKLQEMEGtVKsKYKAsITALEAKIAQLEEQLDNEtK
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P39748	S255	Sugiyama	FEN1 RAD2	CESIRGIGPKRAVDLIQKHKsIEEIVRRLDPNKYPVPENWL
P40227	S200	Sugiyama	CCT6A CCT6 CCTZ	KKQDEPIDLFMIEIMEMKHKsEtDtsLIRGLVLDHGARHPD
P41229	S317	Sugiyama	KDM5C DXS1272E JARID1C SMCX XE169	ELsHsPEPCtKMTMRLRRNHsNAQFIESYVCRMCSRGDEDD
P41236	S24	Sugiyama	PPP1R2 IPP2	STAsHRPIKGILKNKtsttssMVAsAEQPRGNVDEELSKKs
P41236	T22	Sugiyama	PPP1R2 IPP2	AASTAsHRPIKGILKNKtsttssMVAsAEQPRGNVDEELSK
P42566	S746	Sugiyama	EPS15 AF1P	DFSTLSKVNNEDPFRSATSssVsNVVITKNVFEETSVKSED
P42766	S29	Sugiyama	RPL35	LRGKKKEELLKQLDDLKVELsQLRVAKVTGGAASKLsKIRV
P43034	S152	Sugiyama	PAFAH1B1 LIS1 MDCR MDS PAFAHA	IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43490	S472	Sugiyama	NAMPT PBEF PBEF1	EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46459	S17	Sugiyama	NSF	____MAGRSMQAARCPTDELsLtNCAVVNEKDFQsGQHVIV
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46783	S146	Sugiyama	RPS10	TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46940	S482	Sugiyama	IQGAP1 KIAA0051	LINRALESGDVNTVWKQLsssVtGLTNIEEENCQRYLDELM
P47712	S729	Sugiyama	PLA2G4A CPLA2 PLA2G4	KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA
P48643	S235	Sugiyama	CCT5 CCTE KIAA0098	VGGRLEDTKLIKGVIVDKDFsHPQMPKKVEDAKIAILTCPF
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321	T396	Sugiyama	NASP	KDGAVNGPsVVGDQtPIEPQtsIERLtEtKDGsGLEEKVRA
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49368	S252	Sugiyama	CCT3 CCTG TRIC5	YIKNPRIVLLDssLEyKKGEsQtDIEITREEDFTRILQMEE
P49368	S458	Sugiyama	CCT3 CCTG TRIC5	RAVAQALEVIPRTLIQNCGAstIRLLtSLRAKHtQENCEtW
P49588	S775	Sugiyama	AARS1 AARS	VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P49792	S1953	Sugiyama	RANBP2 NUP358	GRGVIFGQTSSTFTFADLAKstsGEGFQFGKKDPNFKGFSG
P49792	S1955	Sugiyama	RANBP2 NUP358	GVIFGQTSSTFTFADLAKstsGEGFQFGKKDPNFKGFSGAG
P50395	S270	Sugiyama	GDI2 RABGDIB	MLNKPIEEIIVQNGKVIGVKsEGEIARCKQLICDPSyVKDR
P50395	T425	Sugiyama	GDI2 RABGDIB	DAttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED
P50851	S1237	Sugiyama	LRBA BGL CDC4L LBA	NLTRETKLINDCHGsVSEAssEQKIAKLDVsNVAtDtERLE
P51532	S1380	Sugiyama	SMARCA4 BAF190A BRG1 SNF2B SNF2L4	EEEEEKMFGRGSRHRKEVDYsDsLTEKQWLKAIEEGtLEEI
P51532	S1382	Sugiyama	SMARCA4 BAF190A BRG1 SNF2B SNF2L4	EEEKMFGRGSRHRKEVDYsDsLTEKQWLKAIEEGtLEEIEE
P52272	S528	Sugiyama	HNRNPM HNRPM NAGR1	IERMGsGVERMGPAIERMGLsMERMVPAGMGAGLERMGPVM
P52298	S13	Sugiyama	NCBP2 CBP20 PIG55	________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52569	S464	Sugiyama	SLC7A2 ATRC2 CAT2	KCsPEKDGLGssPRVTSKsEsQVTMLQRQGFSMRTLFCPSL
P53367	S293	Sugiyama	ARFIP1	DLEELNLGPRDANTLPKIEQsQHLFQAHKEKYDKMRNDVSV
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396	S656	Sugiyama	ACLY	IGNTGGMLDNILASKLyRPGsVAyVSRsGGMsNELNNIISR
P53999	S17	Sugiyama	SUB1 PC4 RPO2TC1	____MPKSKELVsssssGsDsDsEVDKKLKRKKQVAPEKPV
P54105	S198	Sugiyama	CLNS1A CLCI ICLN	TAEGQATLERLEGMLsQsVssQYNMAGVRtEDsIRDyEDGM
P54252	S260	Sugiyama	ATXN3 ATX3 MJD MJD1 SCA3	IDMEDEEADLRRAIQLsMQGssRNIsQDMtQtsGTNLTSEE
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55010	S10	Sugiyama	EIF5	___________MSVNVNRsVsDQFyRyKMPRLIAKVEGKGN
P55036	S266	Sugiyama	PSMD4 MCB1	AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55060	S931	Sugiyama	CSE1L CAS XPO2	KKEHDPVGQMVNNPKIHLAQsLHKLSTACPGRVPSMVSTSL
P55769	S122	Sugiyama	SNU13 NHP2L1	CSVTIKEGSQLKQQIQsIQQsIERLLV______________
P57678	S301	Sugiyama	GEMIN4	QNPYHQQALAEKVKEAERDVsLTSLAKLPSETIFVGCEFLH
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60891	S10	Sugiyama	PRPS1	___________MPNIKIFsGssHQDLSQKIADRLGLELGKV
P60891	S11	Sugiyama	PRPS1	__________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P60900	S175	Sugiyama	PSMA6 PROS27	DPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTV
P60900	S177	Sugiyama	PSMA6 PROS27	AGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTVET
P61163	T248	Sugiyama	ACTR1A CTRN1	PQKDETLETEKAQyyLPDGstIEIGPSRFRAPELLFRPDLI
P61313	S97	Sugiyama	RPL15 EC45 TCBAP0781	KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61978	S417	Sugiyama	HNRNPK HNRPK	DLAGsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITI
P61978	S420	Sugiyama	HNRNPK HNRPK	GsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITItGt
P61981	S64	Sugiyama	YWHAG	LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA
P62191	S244	Sugiyama	PSMC1	LyGPPGtGKTLLAKAVANQTsATFLRVVGSELIQKYLGDGP
P62258	S156	Sugiyama	YWHAE	AtGNDRKEAAENsLVAyKAAsDIAMtELPPTHPIRLGLALN
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62333	S189	Sugiyama	PSMC6 SUG2	GCLLyGPPGTGKTLLARAVAsQLDCNFLKVVSSSIVDKyIG
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62979	S57	Sugiyama	RPS27A UBA80 UBCEP1	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987	S57	Sugiyama	UBA52 UBCEP2	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63220	S65	Sugiyama	RPS21	RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63220	S68	Sugiyama	RPS21	GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63241	S75	Sugiyama	EIF5A	KVHLVGIDIFTGKKyEDICPstHNMDVPNIKRNDFQLIGIQ
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68431	S58	Sugiyama	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	KPHRyRPGtVALREIRRYQKstELLIRKLPFQRLVREIAQD
P78347	S547	Sugiyama	GTF2I BAP135 WBSCR6	IIQVGNRIKFVIKRPELLTHsttEVTQPRtNtPVKEDWNVR
P78371	S470	Sugiyama	CCT2 99D8.1 CCTB	IADNAGYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAI
P83436	S559	Sugiyama	COG7 UNQ3082/PRO10013	NPAEYASLMEILYTLKEKGSsNHNLLAAPRAALTRLNQQAH
P84243	S58	Sugiyama	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	KPHRyRPGtVALREIRRYQKstELLIRKLPFQRLVREIAQD
Q00059	S160	Sugiyama	TFAM TCF6 TCF6L2	RKAMTKKKELTLLGKPKRPRsAYNVyVAERFQEAKGDsPQE
Q00587	S350	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	HyPEMDARQERVEVLPQARAsWEsLDEEWRAPQAGsRtPVP
Q00613	S344	Sugiyama	HSF1 HSTF1	LLsPtALIDsILREsEPAPAsVTALtDARGHTDtEGRPPsP
Q00613	S375	Sugiyama	HSF1 HSTF1	TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01082	S2184	Sugiyama	SPTBN1 SPTB2	ssPIPsPtsDRKAKTALPAQsAAtLPARtQEtPsAQMEGFL
Q01581	S404	Sugiyama	HMGCS1 HMGCS	YSLKVTQDATPGSALDKITAsLCDLKSRLDSRTGVAPDVFA
Q02818	S224	Sugiyama	NUCB1 NUC	RKLEEQQRRHREHPKVNVPGsQAQLKEVWEELDGLDPNRFN
Q02952	S248	Sugiyama	AKAP12 AKAP250	KESEPKQSTEKPEETLKREQsHAEIsPPAESGQAVEECKEE
Q04637	S1238	Sugiyama	EIF4G1 EIF4F EIF4G EIF4GI	RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q04721	S359	Sugiyama	NOTCH2	IDDCAFASCTPGSTCIDRVAsFSCMCPEGKAGLLCHLDDAC
Q04726	S622	Sugiyama	TLE3 KIAA1547	VWDLHNQTLVRQFQGHTDGAsCIDISHDGTKLWTGGLDNTV
Q04726	S743	Sugiyama	TLE3 KIAA1547	LLNAWRTPYGASIFQSKESSsVLSCDISADDKYIVTGSGDK
Q04917	S64	Sugiyama	YWHAH YWHA1	LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA
Q06210	S261	Sugiyama	GFPT1 GFAT GFPT	GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q07021	S205	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	DCHyPEDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYT
Q07157	S1065	Sugiyama	TJP1 ZO1	YVEKQAsRDLEQPtyRyEsssytDQFsRNYEHRLRYEDRVP
Q08209	S492	Sugiyama	PPP3CA CALNA CNA	EAKGLDRINERMPPRRDAMPsDANLNsINKALTSETNGTDS
Q08AD1	S464	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q09028	S146	Sugiyama	RBBP4 RBAP48	EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09028	S147	Sugiyama	RBBP4 RBAP48	VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q09666	S242	Sugiyama	AHNAK PM227	VDIRAGAIsAsGPELQGAGHsKLQVTMPGIKVGGsGVNVNA
Q09666	S5604	Sugiyama	AHNAK PM227	GEGHLsVKGsGGEWKGPQVSsALNLDtSKFAGGLHFsGPKV
Q12982	S114	Sugiyama	BNIP2 NIP2	EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR
Q13098	S483	Sugiyama	GPS1 COPS1 CSN1	QIHVKsPPREGsQGELtPANsQsRMstNM____________
Q13111	S777	Sugiyama	CHAF1A CAF CAF1P150	FQEHCRRGLLSNHTGSPRSPsTTYLHTPTPSEDAAIPSKSR
Q13136	S668	Sugiyama	PPFIA1 LIP1	EEKENTEQRAEEIESRVGsGsLDNLGRFRSMssIPPYPAss
Q13162	S65	Sugiyama	PRDX4	RTREEECHFyAGGQVyPGEAsRVsVADHsLHLSKAKISKPA
Q13243	S153	Sugiyama	SRSF5 HRS SFRS5 SRP40	EVTFADAHRPKLNEGVVEFAsYGDLKNAIEKLSGKEINGRK
Q13263	S471	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	FGsGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLE
Q13263	S473	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13263	S784	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13283	S362	Sugiyama	G3BP1 G3BP	LFIGNLPHEVDKSELKDFFQsyGNVVELRINsGGKLPNFGF
Q13283	S67	Sugiyama	G3BP1 G3BP	sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13509	S115	Sugiyama	TUBB3 TUBB4	SGAGNNWAKGHytEGAELVDsVLDVVRKECENCDCLQGFQL
Q13541	S112	Sugiyama	EIF4EBP1	EAsQsHLRNsPEDKRAGGEEsQFEMDI______________
Q13586	S521	Sugiyama	STIM1 GOK	QRLTEPQHGLGsQRDLtHsDsEssLHMSDRQRVAPKPPQMS
Q13625	S714	Sugiyama	TP53BP2 ASPP2 BBP	PRPLsPtKLLPFLSNPYRNQsDADLEALRKKLSNAPRPLKK
Q13765	S117	Sugiyama	NACA HSD48	RKSKNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQL
Q13765	S186	Sugiyama	NACA HSD48	sEEEEVDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDI
Q13885	S115	Sugiyama	TUBB2A TUBB2	sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q14126	S551	Sugiyama	DSG2 CDHF5	FSVIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFL
Q14157	S471	Sugiyama	UBAP2L KIAA0144 NICE4	PPssPLPsKstsAPQMsPGssDNQsssPQPAQQKLKQQKKK
Q14157	T256	Sugiyama	UBAP2L KIAA0144 NICE4	AWRtAtEEWGtEDWNEDLsEtKIFtAsNVssVPLPAENVtI
Q14203	S31	Sugiyama	DCTN1	RTPSGSRMsAEASARPLRVGsRVEVIGKGHRGTVAYVGATL
Q14257	S37	Sugiyama	RCN2 ERC55	AAAAGAGKAEELHyPLGERRsDyDREALLGVQEDVDEyVKL
Q14258	T341	Sugiyama	TRIM25 EFP RNF147 ZNF147	PVYIPEVELNHKLIKGIHQstIDLKNELKQCIGRLQEPTPS
Q14432	T311	Sugiyama	PDE3A	RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14966	S1228	Sugiyama	ZNF638 NP220 ZFML	DLEKKGAEIINPKTALLPSDsVFAEERNLKGILEEsPsEAE
Q14980	S1181	Sugiyama	NUMA1 NMP22 NUMA	DsALEtLQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQD
Q14980	S1183	Sugiyama	NUMA1 NMP22 NUMA	ALEtLQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQDHS
Q15021	S1333	Sugiyama	NCAPD2 CAPD2 CNAP1 KIAA0159	APsAKKPSTGSRyQPLAstAsDNDFVtPEPRRTTRRHPNTQ
Q15021	T586	Sugiyama	NCAPD2 CAPD2 CNAP1 KIAA0159	LGLIFKGPAASTQEKNPREstGNMVTGQTVCKNKPNMsDPE
Q15075	S76	Sugiyama	EEA1 ZFYVE2	LFKHYEAVHDAGNDsGHGGEsNLALKRDDVTLLRQEVQDLQ
Q15084	S377	Sugiyama	PDIA6 ERP5 P5 TXNDC7	PAMAAINARKMKFALLKGsFsEQGINEFLRELsFGRGstAP
Q15172	S472	Sugiyama	PPP2R5A	EELWKKLEELKLKKALEKQNsAyNMHSILSNTSAE______
Q15185	S113	Sugiyama	PTGES3 P23 TEBP	RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15185	S82	Sugiyama	PTGES3 P23 TEBP	NDsKHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVD
Q15293	S80	Sugiyama	RCN1 RCN	HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q15398	S789	Sugiyama	DLGAP5 DLG7 KIAA0008	EKNTAsQNsILEEGEtKIsQsELFDNKsLttECHLLDsPGL
Q15417	S175	Sugiyama	CNN3	GKLKAGQsVIGLQMGTNKCAsQAGMTAyGtRRHLYDPKMQT
Q15642	S296	Sugiyama	TRIP10 CIP4 STOT STP	FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15750	S339	Sugiyama	TAB1 MAP3K7IP1	KQTSLDAVAQAVVDRVKRIHsDTFASGGERARFCPRHEDMT
Q15785	S93	Sugiyama	TOMM34 URCC3	DCTSALALVPFSIKPLLRRAsAyEALEKYPMAYVDYKTVLQ
Q15818	S91	Sugiyama	NPTX1	TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16576	S145	Sugiyama	RBBP7 RBAP46	EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576	S146	Sugiyama	RBBP7 RBAP46	VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16643	S339	Sugiyama	DBN1 D0S117E	GsHLDsHRRMAPtPIPtRsPsDsstAstPVAEQIERALDEV
Q16695	S58	Sugiyama	H3-4 H3FT HIST3H3	KPHRyRPGtVALREIRRYQKstELLIRKLPFQRLMREIAQD
Q16836	S196	Sugiyama	HADH HAD HAD1 HADHSC SCHAD	PVMKLVEVIKTPMTSQKTFEsLVDFSKALGKHPVSCKDTPG
Q3V6T2	S1702	Sugiyama	CCDC88A APE GRDN KIAA1212	TLQQFLEEsNKLTSVQIKsssQENLLDEVMKSLsVssDFLG
Q4V328	S666	Sugiyama	GRIPAP1 KIAA1167	EELVLsEMNsPSRtQtGDsssIssFsYREILREKEssAVPA
Q53EL6	S46	Sugiyama	PDCD4 H731	GDEENAGTEEIKNEINGNWIsAssINEARINAKAKRRLRKN
Q53EL6	S48	Sugiyama	PDCD4 H731	EENAGTEEIKNEINGNWIsAssINEARINAKAKRRLRKNss
Q58FF7	S405	Sugiyama	HSP90AB3P HSP90BC	YMTEPIDEYCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKK
Q58FF8	S266	Sugiyama	HSP90AB2P HSP90BB	EEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVWKRDSRV
Q58FF8	S305	Sugiyama	HSP90AB2P HSP90BB	RVVYMTEPIDGYQLKEFDGKsLVsVtKEGLELPEDGEEKKR
Q5JTV8	T166	Sugiyama	TOR1AIP1 LAP1	MtRRGLRDsHssEEDEAssQtDLsQTISKKtVRsIQEAPVs
Q5T035	S66	Sugiyama	FAM120A2P C9orf129	LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI
Q5T1M5	S1092	Sugiyama	FKBP15 KIAA0674	DNPSGKVCVREVAPDGPLQEsstRLsLtsDPEEGDPLALGP
Q5TAX3	S831	Sugiyama	TUT4 KIAA0191 ZCCHC11	KLDKKQDDLAPSETCLKKELsQCNCIDLsKsPDPDKSTGTD
Q5UIP0	S1688	Sugiyama	RIF1	PVPESNLRTRNAIKRLHKRDsFDNCsLGESSKIGIsDIssL
Q5VZL5	S245	Sugiyama	ZMYM4 KIAA0425 ZNF262	SSYPFANKESIGSELGNsFAsNIRIKEEPLDDEYDKAMAPQ
Q6DHY5	T152	Sugiyama	TBC1D3G	KEKGKRSSEHIQRIDRDISGtLRKHMFFRDRYGTKQRELLH
Q6GYQ0	T798	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6IPX1	T152	Sugiyama	TBC1D3C TBC1D3D	KEKGKRSSEHIQRIDRDVSGtLRKHIFFRDRYGTKQRELLH
Q6IS14	S75	Sugiyama	EIF5AL1	KVHLVGIDIFTGKKyEDICPstHNMDVPNIKRNDFQLIGIQ
Q6NXT2	S57	Sugiyama	H3-5 H3F3C	KPHRyRPGtVALREIRRYQKstELLIRKLPFQRLVREIAQD
Q6P1J9	S178	Sugiyama	CDC73 C1orf28 HRPT2	EGHKEGIVQTEQIRSLsEAMsVEKIAAIKAKIMAKKRSTIK
Q6P996	S722	Sugiyama	PDXDC1 KIAA0251	PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI
Q6PCE3	S311	Sugiyama	PGM2L1 BM32A	QKDPDPDFSTVKCPNPEEGEsVLELsLRLAEKENARVVLAT
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6UB35	S361	Sugiyama	MTHFD1L FTHFSDC1	QQHRRWRLHCLKLQPLsPVPsDIEIsRGQTPKAVDVLAKEI
Q6UB35	S366	Sugiyama	MTHFD1L FTHFSDC1	WRLHCLKLQPLsPVPsDIEIsRGQTPKAVDVLAKEIGLLAD
Q6UX04	S203	Sugiyama	CWC27 SDCCAG10 UNQ438/PRO871	KKEKPEEEVKKLKPKGTKNFsLLsFGEEAEEEEEEVNRVSQ
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71DI3	S58	Sugiyama	H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D	KPHRyRPGtVALREIRRYQKstELLIRKLPFQRLVREIAQD
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q7Z2W4	S498	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	IADDADPRVALVNDsLsDVtsTtssRVDDHDSEEICLDHLC
Q7Z3J3	S978	Sugiyama	RGPD4 RGP4	GRGVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSG
Q7Z3J3	S980	Sugiyama	RGPD4 RGP4	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
Q7Z3T8	S360	Sugiyama	ZFYVE16 KIAA0305	QSAQEDsKsLDLKDNDVIQDsSsALHVSSKDVPSSLSCLPA
Q7Z417	S608	Sugiyama	NUFIP2 KIAA1321 PIG1	sGALsLEPsHIGDLQKADtssQGALVFLSKDYEIEsQNPLA
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z6Z7	S2535	Sugiyama	HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272	THPLMVRHADHssLtLGsGssttRLtQGIGRsQRTLRQLTA
Q7Z7E8	S401	Sugiyama	UBE2Q1 NICE5 UBE2Q PRO3094	KARVQFGANKSQYSLTRAQQsyKsLVQIHEKNGWYtPPKED
Q7Z7E8	S404	Sugiyama	UBE2Q1 NICE5 UBE2Q PRO3094	VQFGANKSQYSLTRAQQsyKsLVQIHEKNGWYtPPKEDG__
Q86TC9	S198	Sugiyama	MYPN MYOP	CKNHKSKLESQNKVMQENSssFsDLSERRERSSVPIPIPAD
Q86TC9	S200	Sugiyama	MYPN MYOP	NHKSKLESQNKVMQENSssFsDLSERRERSSVPIPIPADTR
Q86TU7	S505	Sugiyama	SETD3 C14orf154	NREYYRQQMEEKAPLPKyEEsNLGLLEssVGDSRLPLVLRN
Q86UF2	S138	Sugiyama	CTAGE6 CTAGE6P	EKAAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKS
Q86UF2	S140	Sugiyama	CTAGE6 CTAGE6P	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86V48	S794	Sugiyama	LUZP1	TETTLEKQKPVSKPGPNKVTsSITIYPsDsssPRAAPGEAL
Q86V81	S8	Sugiyama	ALYREF ALY BEF THOC4	_____________MADKMDMsLDDIIKLNRSQRGGRGGGRG
Q86W92	S638	Sugiyama	PPFIBP1 KIAA1230	GTRATAGPRLGWsRDLGQsNsDLDMPFAKWTKEQVCNWLME
Q8IWW6	S223	Sugiyama	ARHGAP12	GEGSERIHQDSEsGDELSSSsTEQIRAttPPNQGRPDsPVy
Q8IWZ3	S214	Sugiyama	ANKHD1 KIAA1085 MASK VBARP PP2500	KAENsHNAGQVDTRsLAEACsDGDVNAVRKLLDEGRSVNEH
Q8IX94	S138	Sugiyama	CTAGE4	EKAAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKS
Q8IX94	S140	Sugiyama	CTAGE4	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8IYB3	S240	Sugiyama	SRRM1 SRM160	tPELPEPsVKVKEPsVQEAtstsDILKVPKPEPIPEPKEPs
Q8N3D4	S927	Sugiyama	EHBP1L1	TQPRVLGSQEAKAEISGVQGsETQVLRVQEAEAGVWGMSEG
Q8N6T3	S345	Sugiyama	ARFGAP1 ARF1GAP	DQSFWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWE
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NEM2	S42	Sugiyama	SHCBP1	GWAVEQELASLEKGLFQDEDsCsDCsYRDKPGssLQSFMPE
Q8NEZ2	S12	Sugiyama	VPS37A HCRP1	_________MSWLFPLTKsAsssAAGsPGGLTSLQQQKQRL
Q8NEZ2	S326	Sugiyama	VPS37A HCRP1	QMKSTFEKKMQRQHELSEsCsASALQARLKVAAHEAEEESD
Q8NHW5	S307	Sugiyama	RPLP0P6	AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
Q8TDD1	S624	Sugiyama	DDX54	FQQGQQGRQEQQEGPVGPAPsRPALQEKQPEKEEEEEAGEs
Q8TEW0	S840	Sugiyama	PARD3 PAR3 PAR3A	REGFGRQsMsEKRtKQFsDAsQLDFVKTRKsKsMDLGIADE
Q8WUA7	S145	Sugiyama	TBC1D22A C22orf4	RPEAEPPsPPsGDLRLVKsVsEsHtsCPAESASDAAPLQRs
Q8WWH5	S268	Sugiyama	TRUB1 PUS4	ECGGGFYIRSLVSDIGKELSsCANVLELTRTKQGPFTLEEH
Q8WWI1	S1510	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	RsAsVNKEPVSLPGIMRRGEsLDNLDsPRSNSWRQPPWLNQ
Q8WXH0	T1397	Sugiyama	SYNE2 KIAA1011 NUA	LDKCLKMLDMSFKDAERGDDtSCENLLDAFSIKLSETHGYG
Q8WYP5	S1343	Sugiyama	AHCTF1 ELYS TMBS62 MSTP108	DAPSPEDLEETVFTASKPKsssTALttNVtEQtEKDGDKDV
Q92574	T1047	Sugiyama	TSC1 KIAA0243 TSC	RGSSGSRGGGGssssssELstPEKPPHQRAGPFSSRWETTM
Q92609	S541	Sugiyama	TBC1D5 KIAA0210	EsMPVQLNKGLSSKNIsssPsVEsLPGGREFtGsPPssAtK
Q92945	S193	Sugiyama	KHSRP FUBP2	DSGCKVQIsPDsGGLPERsVsLtGAPEsVQKAKMMLDDIVS
Q93045	S80	Sugiyama	STMN2 SCG10 SCGN10	PPsPISEAPRTLAsPKKKDLsLEEIQKKLEAAEERRKsQEA
Q969G3	S316	Sugiyama	SMARCE1 BAF57	ARKRQEEREKEAAEQAERsQssIVPEEEQAANKGEEKKDDE
Q96CT7	S122	Sugiyama	CCDC124	DtLRRDHQLREAPDTAEKAKsHLEVPLEENVNRRVLEEGsV
Q96D15	S76	Sugiyama	RCN3 UNQ239/PRO272	HEAFLGREVAKEFDQLtPEEsQARLGRIVDRMDRAGDGDGW
Q96D15	S98	Sugiyama	RCN3 UNQ239/PRO272	ARLGRIVDRMDRAGDGDGWVsLAELRAWIAHTQQRHIRDsV
Q96EP5	S193	Sugiyama	DAZAP1	MHFHDIMGKKVEVKRAEPRDsKsQAPGQPGAsQWGsRVVPN
Q96ES7	S29	Sugiyama	SGF29 CCDC101	RIAELLTELHQLIKQTQEERsRsEHNLVNIQKTHERMQTEN
Q96ES7	S31	Sugiyama	SGF29 CCDC101	AELLTELHQLIKQTQEERsRsEHNLVNIQKTHERMQTENKI
Q96GQ7	S79	Sugiyama	DDX27 cPERP-F RHLP HSPC259 PP3241	EEEEGPIVLGRRQKALGKNRsADFNPDFVFTEKEGTyDGsW
Q96HC4	S362	Sugiyama	PDLIM5 ENH L9	SLTAAAAFKPVGStGVIKsPsWQRPNQGVPstGRIsNsAtY
Q96IZ0	Y226	Sugiyama	PAWR PAR4	LLDPGSsyLLQEPPRTVSGRyKsttsVsEEDVsSRYsRTDR
Q96JH7	S1077	Sugiyama	VCPIP1 KIAA1850 VCIP135	GTDFSNSsTKTEPSVFTASSsNsELIRIAPGVVTMRDGRQL
Q96N67	S1432	Sugiyama	DOCK7 KIAA1771	RRSRGQLGTYTIAsPPERsPsGsAFGsQENLRWRKDMTHWR
Q96N67	S1438	Sugiyama	DOCK7 KIAA1771	LGTYTIAsPPERsPsGsAFGsQENLRWRKDMTHWRQNTEKL
Q96PK6	S520	Sugiyama	RBM14 SIP	AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q96T88	S95	Sugiyama	UHRF1 ICBP90 NP95 RNF106	QsLVLPHSTKERDsELsDtDsGCCLGQSESDKsstHGEAAA
Q99439	S138	Sugiyama	CNN2	TQVQVSLLALAGKAKTKGLQsGVDIGVKYSEKQERNFDDAT
Q99439	S177	Sugiyama	CNN2	ATMKAGQCVIGLQMGTNKCAsQSGMTAyGTRRHLYDPKNHI
Q99439	S217	Sugiyama	CNN2	ILPPMDHSTISLQMGTNKCAsQVGMTAPGTRRHIyDTKLGT
Q99613	S754	Sugiyama	EIF3C EIF3S8	REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK
Q99618	S94	Sugiyama	CDCA3 C8 GRCC8 TOME1	ARtPMKTSsGDPPsPLVKQLsEVFETEDSKSNLPPEPVLPP
Q99666	S977	Sugiyama	RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6	GRGVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSG
Q99666	S979	Sugiyama	RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
Q99798	S389	Sugiyama	ACO2	EKEGWPLDIRVGLIGSCTNssyEDMGRSAAVAKQALAHGLK
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQS8	S425	Sugiyama	FYCO1 ZFYVE7	EKLQALERERTKVEEVNRQQsAQLEQLVKELQLKEDARASL
Q9BTC0	S975	Sugiyama	DIDO1 C20orf158 DATF1 KIAA0333	SGVVTTVTVSGRDPRTAPSSsCTAVASAASRPDsTHMVEAR
Q9BVA1	S115	Sugiyama	TUBB2B	sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q9BXA7	S290	Sugiyama	TSSK1B SPOGA1 SPOGA4 STK22A STK22D TSSK1 FKSG81	CWMQPKARGSPSVAINKEGEsSRGtEPLWtPEPGSDKKSAT
Q9BXA7	T174	SIGNOR	TSSK1B SPOGA1 SPOGA4 STK22A STK22D TSSK1 FKSG81	DFSFSKRCLRDDSGRMALSKtFCGSPAYAAPEVLQGIPYQP
Q9BXA7	T294	Sugiyama	TSSK1B SPOGA1 SPOGA4 STK22A STK22D TSSK1 FKSG81	PKARGSPSVAINKEGEsSRGtEPLWtPEPGSDKKSATKLEP
Q9BXA7	T299	Sugiyama	TSSK1B SPOGA1 SPOGA4 STK22A STK22D TSSK1 FKSG81	SPSVAINKEGEsSRGtEPLWtPEPGSDKKSATKLEPEGEAQ
Q9C0C2	S429	Sugiyama	TNKS1BP1 KIAA1741 TAB182	EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9GZV4	S75	Sugiyama	EIF5A2	KVHLVGIDIFTGKKyEDICPstHNMDVPNIKRNDYQLICIQ
Q9H2G2	S340	Sugiyama	SLK KIAA0204 STK2	EEDEEEEtENsLPIPAsKRAssDLsIAssEEDKLsQNACIL
Q9H2G2	S341	Sugiyama	SLK KIAA0204 STK2	EDEEEEtENsLPIPAsKRAssDLsIAssEEDKLsQNACILE
Q9H2G2	S518	Sugiyama	SLK KIAA0204 STK2	tVDLVSQEtGEKEANIQAVDsEVGLTKEDtQEKLGEDDKTQ
Q9H3P7	S316	Sugiyama	ACBD3 GCP60 GOCAP1 GOLPH1	QLAQQQAALQKQQEVVVAGssLPtssKVNATVPSNMMSVNG
Q9H6S3	S693	Sugiyama	EPS8L2 EPS8R2 PP13181	EGVRVySQLTMQKAFLEKQQsGSELEELMNKFHSMNQRRGE
Q9H788	S118	Sugiyama	SH2D4A PPP1R38 SH2A	IAERARLKAEQEAEEPRKTHsEEFTNsLKTKsQyHDLQAPD
Q9H7E9	T40	Sugiyama	C8orf33	PCAsRGARLPGPVsSARNPstVCLCPEQPTCSNADSRAHPL
Q9HAU0	S410	Sugiyama	PLEKHA5 KIAA1686 PEPP2	NRPNTGPLytEADRVIQRtNsMQQLEQWIKIQKGRGHEEET
Q9HCN8	S40	Sugiyama	SDF2L1 UNQ1941/PRO4424	ALLVPGGGAAKTGAELVTCGsVLKLLNTHHRVRLHSHDIKY
Q9HD42	S101	Sugiyama	CHMP1A CHMP1 KIAA0047 PCOLN3 PRSM1	TMKGVTKNMAQVTKALDKALsTMDLQKVSSVMDRFEQQVQN
Q9NP61	S457	Sugiyama	ARFGAP3 ARFGAP1	sQADYETRARLERLsAsssIssADLFEEPRKQPAGNysLSS
Q9NPF0	S142	Sugiyama	CD320 8D6A UNQ198/PRO224	KKLRNCSRLACLAGELRCTLsDDCIPLTWRCDGHPDCPDSS
Q9NQ39	S157	Sugiyama	RPS10P5 RPS10L	TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NRZ9	T166	Sugiyama	HELLS PASG SMARCA6 Nbla10143	EILSVAKKNKKENEDENssstNLCVEDLQKNKDSNSIIKDR
Q9NSV4	S1119	Sugiyama	DIAPH3 DIAP3	PVLKVCNHENQKVQLTEGSRsHYNINCNstRtPVAKELNyN
Q9NTJ3	S504	Sugiyama	SMC4 CAPC SMC4L1	ELMGFSKSVNEARSKMDVAQsELDIyLSRHNTAVSQLTKAK
Q9NUU7	S444	Sugiyama	DDX19A DDX19L	HRIGRTGRFGKRGLAVNMVDsKHSMNILNRIQEHFNKKIER
Q9NVN8	S513	Sugiyama	GNL3L	PNRHQMGWAKRNVDHRPKsNsMVDVCsVDRRSVLQRIMETD
Q9NW68	S387	Sugiyama	BSDC1 UNQ2494/PRO5781	VFELNsDsGKSTPSNNGKKGsstDIsEDWEKDFDLDMTEEE
Q9NW82	S87	Sugiyama	WDR70	MNREKELRRQNEDIEPTSSRsNVVRDCSKSSSRDTSSSESE
Q9NWS0	S175	Sugiyama	PIH1D1 NOP17	NLQLNPEWRMMKNRPFMGsIsQQNIRSEQRPRIQELGDLyt
Q9NXV6	S175	Sugiyama	CDKN2AIP CARF	EQDHAKTSAKTERASAQQENsSTCIGsAIKSESGNSARssG
Q9NYB9	S22	Sugiyama	ABI2 ARGBPIA	AELQMLLEEEIPGGRRALFDsytNLERVADyCENNyIQSAD
Q9NYL9	S25	Sugiyama	TMOD3	FRKDLEKyKDLDEDELLGNLsEtELKQLETVLDDLDPENAL
Q9NZ09	S207	Sugiyama	UBAP1 NAG20	TTGPIMAQLLDNNLPRGGsGsVLQDEEVLAsLERATLDFKP
Q9NZB2	S417	Sugiyama	FAM120A C9orf10 KIAA0183 OSSA	LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI
Q9NZM1	S174	Sugiyama	MYOF FER1L3 KIAA1207	EDRLDNAVRGPGPKGPVGtVsEAQLARRLtKVKNSRRMLSN
Q9P2E9	S1321	Sugiyama	RRBP1 KIAA1398	LEDEQtQRQKLTAEFEEAQTsACRLQEELEKLRTAGPLEsS
Q9UBF8	T426	Sugiyama	PI4KB PIK4CB	CENFDTTSVPARIPENRIRstRsVENLPECGItHEQRAGSF
Q9UGP4	S667	Sugiyama	LIMD1	PLEDHLFCHsCHVKRLEKRPsstALHQHHF___________
Q9UHF7	S784	Sugiyama	TRPS1	VVKREKLEEKDGLKEKVWTEsSSDDLRNVTWRGADILRGsP
Q9UHG3	S447	Sugiyama	PCYOX1 KIAA0908 PCL1 UNQ597/PRO1183	YAVKKPWLAYPHYKPPEKCPsIILHDRLYYLNGIECAASAM
Q9UHR4	S354	Sugiyama	BAIAP2L1 IRTKS	TGLNMMKKQKVKTIFPHtAGsNKTLLSFAQGDVITLLIPEE
Q9UHX1	S461	Sugiyama	PUF60 FIR ROBPI SIAHBP1	sIsGssARHMVMQKLLRKQEsTVMVLRNMVDPKDIDDDLEG
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UJA5	S475	Sugiyama	TRMT6 KIAA1153 TRM6 CGI-09	SGFTVAMDNLKADtSLKsNAstLESHETEEPAAKKRKCPES
Q9ULD2	S199	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	GKsQsFHtAGSLPPTGRRsGstsSLSySTWTSSHSDKTHAR
Q9UMR2	S445	Sugiyama	DDX19B DBP5 DDX19 TDBP	HRIGRTGRFGKRGLAVNMVDsKHSMNILNRIQEHFNKKIER
Q9UNF1	T81	Sugiyama	MAGED2 BCG1	SGVSKAtEVsKtPEAREAPAtQAssttQLtDtQVLAAENKS
Q9UNL2	S11	Sugiyama	SSR3 TRAPG	__________MAPKGssKQQsEEDLLLQDFSRNLSAKSSAL
Q9UNZ2	S176	Sugiyama	NSFL1C UBXN2C	RLGAAPEEEsAyVAGEKRQHssQDVHVVLKLWKsGFsLDNG
Q9UPQ0	S585	Sugiyama	LIMCH1 KIAA1102	ETVHREEEKERECPTVAPAHsLtKSQMFEGVARVHGsPLEL
Q9UQ35	S1455	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	PsRRsRsGssPGLRDGsGtPsRHsLsGssPGMKDIPRtPSR
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35	S2355	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sANLVGPRsAHAtAPVNIAGsRtAAALAPAsLtsARMAPAL
Q9UQ35	S2459	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	LLPPAQDQPRsPVPsAFsDQsRCLIAQTTPVAGSQSLSSGA
Q9UQ35	S992	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sssPDtKVKPEtPPRQsHsGsIsPyPKVKAQtPPGPsLsGs
Q9UQ80	S41	Sugiyama	PA2G4 EBP1	YKMGGDIANRVLRsLVEASssGVsVLsLCEKGDAMIMEEtG
Q9UQ80	S44	Sugiyama	PA2G4 EBP1	GGDIANRVLRsLVEASssGVsVLsLCEKGDAMIMEEtGKIF
Q9Y2B0	S116	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0	S74	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	GsFRINPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGE
Q9Y2B0	T79	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	NPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGEQIDPs
Q9Y2U5	S21	Sugiyama	MAP3K2 MAPKKK2 MEKK2	MDDQQALNSIMQDLAVLHKAsRPALsLQETRKAKSSSPKKQ
Q9Y383	S50	Sugiyama	LUC7L2 CGI-59 CGI-74	FSDDRVCKSHLLNCCPHDVLsGTRMDLGECLKVHDLALRAD
Q9Y450	S69	Sugiyama	HBS1L HBS1 KIAA1038	sVEPVEEyDyEDLKEssNsVsNHQLSGFDQARLYsCLDHMR
Q9Y490	S1535	Sugiyama	TLN1 KIAA1027 TLN	RTTNPTAKRQFVQSAKEVANsTANLVKTIKALDGAFTEENR
Q9Y4G6	S1537	Sugiyama	TLN2 KIAA0320	KTANPVAKRHFVQSAKEVANsTANLVKTIKALDGDFSEDNR
Q9Y4W2	S641	Sugiyama	LAS1L MSTP060	ENARLLAQKRGALQGsAWQVssEDVRWDTFPLGRMPGQTED
Q9Y4X5	S514	Sugiyama	ARIH1 ARI MOP6 UBCH7BP HUSSY-27	NQADLENATEVLSGYLERDIsQDsLQDIKQKVQDKYRYCES
Q9Y6Y8	S894	Sugiyama	SEC23IP MSTP053	FISSLKSAWQTLNEFARAHtsstQLQEELEKVANQIKEEEE

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	1.280110e-10	9.893
Cell Cycle, Mitotic	R-HSA-69278	8.334701e-10	9.079
Signal Transduction	R-HSA-162582	3.565316e-09	8.448
Mitotic Prometaphase	R-HSA-68877	1.646276e-08	7.783
Cellular response to heat stress	R-HSA-3371556	4.699072e-08	7.328
M Phase	R-HSA-68886	2.111867e-07	6.675
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.254650e-06	5.901
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.530792e-06	5.815
Axon guidance	R-HSA-422475	1.864249e-06	5.729
Cell Cycle Checkpoints	R-HSA-69620	2.215124e-06	5.655
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.240434e-06	5.650
Amplification of signal from the kinetochores	R-HSA-141424	5.306460e-06	5.275
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	5.306460e-06	5.275
Apoptotic execution phase	R-HSA-75153	4.857079e-06	5.314
Apoptotic cleavage of cellular proteins	R-HSA-111465	9.316113e-06	5.031
Nervous system development	R-HSA-9675108	1.013032e-05	4.994
Mitotic G2-G2/M phases	R-HSA-453274	1.041860e-05	4.982
HSF1-dependent transactivation	R-HSA-3371571	2.005734e-05	4.698
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.800961e-05	4.744
Separation of Sister Chromatids	R-HSA-2467813	1.759473e-05	4.755
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.398914e-05	4.620
Kinesins	R-HSA-983189	2.605846e-05	4.584
Mitotic Spindle Checkpoint	R-HSA-69618	2.810445e-05	4.551
G2/M Transition	R-HSA-69275	2.892889e-05	4.539
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.517485e-05	4.454
Muscle contraction	R-HSA-397014	1.216685e-04	3.915
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.379686e-04	3.860
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.552055e-04	3.809
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.722516e-04	3.764
NRAGE signals death through JNK	R-HSA-193648	1.784759e-04	3.748
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.847065e-04	3.734
Transcriptional Regulation by MECP2	R-HSA-8986944	2.101130e-04	3.678
Death Receptor Signaling	R-HSA-73887	2.238144e-04	3.650
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.410811e-04	3.618
Centrosome maturation	R-HSA-380287	2.508892e-04	3.601
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.236236e-04	3.490
Semaphorin interactions	R-HSA-373755	3.145065e-04	3.502
Mitotic Anaphase	R-HSA-68882	3.203911e-04	3.494
Apoptosis	R-HSA-109581	3.226290e-04	3.491
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.545898e-04	3.450
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.148660e-04	3.382
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.925084e-04	3.406
Chromatin modifying enzymes	R-HSA-3247509	4.053205e-04	3.392
Post NMDA receptor activation events	R-HSA-438064	4.930422e-04	3.307
p75 NTR receptor-mediated signalling	R-HSA-193704	4.908185e-04	3.309
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.211270e-04	3.283
AURKA Activation by TPX2	R-HSA-8854518	5.572327e-04	3.254
Selective autophagy	R-HSA-9663891	5.781481e-04	3.238
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	6.222923e-04	3.206
Intracellular signaling by second messengers	R-HSA-9006925	6.780449e-04	3.169
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	7.278863e-04	3.138
Loss of Nlp from mitotic centrosomes	R-HSA-380259	7.278863e-04	3.138
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	8.323483e-04	3.080
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	8.631152e-04	3.064
Programmed Cell Death	R-HSA-5357801	8.503069e-04	3.070
Chromatin organization	R-HSA-4839726	9.837833e-04	3.007
Attenuation phase	R-HSA-3371568	1.088676e-03	2.963
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.137136e-03	2.944
Diseases of programmed cell death	R-HSA-9645723	1.185236e-03	2.926
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.281212e-03	2.892
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.471514e-03	2.832
ChREBP activates metabolic gene expression	R-HSA-163765	1.540466e-03	2.812
G alpha (12/13) signalling events	R-HSA-416482	1.914340e-03	2.718
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.940173e-03	2.712
Glycolysis	R-HSA-70171	2.157594e-03	2.666
Cellular responses to stress	R-HSA-2262752	2.159495e-03	2.666
Transcriptional regulation by RUNX1	R-HSA-8878171	2.168576e-03	2.664
Signaling by AXIN mutants	R-HSA-4839735	2.348861e-03	2.629
Signaling by GSK3beta mutants	R-HSA-5339716	2.348861e-03	2.629
Signaling by Hippo	R-HSA-2028269	2.284325e-03	2.641
Cellular Senescence	R-HSA-2559583	2.383334e-03	2.623
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	2.406852e-03	2.619
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.511935e-03	2.600
Neurodegenerative Diseases	R-HSA-8863678	2.511935e-03	2.600
HSF1 activation	R-HSA-3371511	2.890658e-03	2.539
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.082231e-03	2.511
TCF dependent signaling in response to WNT	R-HSA-201681	3.138995e-03	2.503
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.246517e-03	2.489
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	3.457150e-03	2.461
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	3.457150e-03	2.461
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	3.457150e-03	2.461
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	3.457150e-03	2.461
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	3.457150e-03	2.461
Cellular responses to stimuli	R-HSA-8953897	3.449082e-03	2.462
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	3.608399e-03	2.443
Striated Muscle Contraction	R-HSA-390522	3.800413e-03	2.420
Metabolism of non-coding RNA	R-HSA-194441	3.846039e-03	2.415
snRNP Assembly	R-HSA-191859	3.846039e-03	2.415
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	4.009717e-03	2.397
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	4.013638e-03	2.396
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.946509e-03	2.404
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	4.090764e-03	2.388
PIP3 activates AKT signaling	R-HSA-1257604	4.170644e-03	2.380
Signaling by RAS mutants	R-HSA-6802949	4.407600e-03	2.356
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	4.407600e-03	2.356
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	4.407600e-03	2.356
Signaling downstream of RAS mutants	R-HSA-9649948	4.407600e-03	2.356
Autophagy	R-HSA-9612973	4.477889e-03	2.349
Macroautophagy	R-HSA-1632852	4.390624e-03	2.357
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	4.500660e-03	2.347
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.538170e-03	2.343
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.602571e-03	2.337
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	5.003781e-03	2.301
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	5.003781e-03	2.301
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.090854e-03	2.293
Oncogenic MAPK signaling	R-HSA-6802957	5.092247e-03	2.293
Signaling by APC mutants	R-HSA-4839744	6.049538e-03	2.218
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	6.049538e-03	2.218
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	6.049538e-03	2.218
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	6.049538e-03	2.218
Transcriptional regulation of granulopoiesis	R-HSA-9616222	6.103990e-03	2.214
Aggrephagy	R-HSA-9646399	6.371139e-03	2.196
Interactions of Vpr with host cellular proteins	R-HSA-176033	6.371139e-03	2.196
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	6.847926e-03	2.164
Glucose metabolism	R-HSA-70326	6.782764e-03	2.169
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	7.171193e-03	2.144
IPs transport between nucleus and cytosol	R-HSA-1855170	7.581324e-03	2.120
PKMTs methylate histone lysines	R-HSA-3214841	7.629254e-03	2.118
MyD88-independent TLR4 cascade	R-HSA-166166	7.830996e-03	2.106
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	7.830996e-03	2.106
EPH-Ephrin signaling	R-HSA-2682334	8.296178e-03	2.081
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	8.404635e-03	2.075
Sema4D in semaphorin signaling	R-HSA-400685	8.719595e-03	2.060
Signaling by RAF1 mutants	R-HSA-9656223	9.077981e-03	2.042
Oxidative Stress Induced Senescence	R-HSA-2559580	9.032383e-03	2.044
Signaling by AMER1 mutants	R-HSA-4839748	8.634784e-03	2.064
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	9.213460e-03	2.036
Beta-catenin phosphorylation cascade	R-HSA-196299	9.278990e-03	2.032
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	9.347376e-03	2.029
Chaperone Mediated Autophagy	R-HSA-9613829	9.383898e-03	2.028
Regulation of TP53 Activity	R-HSA-5633007	1.025323e-02	1.989
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.023858e-02	1.990
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.023858e-02	1.990
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.023858e-02	1.990
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.006103e-02	1.997
Transcriptional Regulation by TP53	R-HSA-3700989	1.057301e-02	1.976
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.067099e-02	1.972
Metalloprotease DUBs	R-HSA-5689901	1.083153e-02	1.965
Nuclear import of Rev protein	R-HSA-180746	1.110849e-02	1.954
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.195102e-02	1.923
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.196303e-02	1.922
Transcriptional Regulation by E2F6	R-HSA-8953750	1.196303e-02	1.922
The NLRP3 inflammasome	R-HSA-844456	1.208593e-02	1.918
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.267808e-02	1.897
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.329270e-02	1.876
Estrogen-dependent gene expression	R-HSA-9018519	1.219162e-02	1.914
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.221529e-02	1.913
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.240774e-02	1.906
Golgi-to-ER retrograde transport	R-HSA-8856688	1.260164e-02	1.900
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.338295e-02	1.873
Host Interactions of HIV factors	R-HSA-162909	1.343651e-02	1.872
Smooth Muscle Contraction	R-HSA-445355	1.346526e-02	1.871
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.374598e-02	1.862
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.374598e-02	1.862
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.374598e-02	1.862
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.374598e-02	1.862
G1/S DNA Damage Checkpoints	R-HSA-69615	1.381589e-02	1.860
EPHB-mediated forward signaling	R-HSA-3928662	1.476002e-02	1.831
Signaling by WNT in cancer	R-HSA-4791275	1.471484e-02	1.832
Mitotic Prophase	R-HSA-68875	1.519956e-02	1.818
RMTs methylate histone arginines	R-HSA-3214858	1.476002e-02	1.831
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.523553e-02	1.817
Signaling by WNT	R-HSA-195721	1.491613e-02	1.826
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.428091e-02	1.845
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	1.523553e-02	1.817
Interactions of Rev with host cellular proteins	R-HSA-177243	1.413336e-02	1.850
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.531212e-02	1.815
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.532904e-02	1.814
Calmodulin induced events	R-HSA-111933	1.579274e-02	1.802
CaM pathway	R-HSA-111997	1.579274e-02	1.802
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.598637e-02	1.796
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.917004e-02	1.717
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.620557e-02	1.790
Meiosis	R-HSA-1500620	1.698694e-02	1.770
Meiotic recombination	R-HSA-912446	2.014648e-02	1.696
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.011580e-02	1.696
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.954260e-02	1.709
Ub-specific processing proteases	R-HSA-5689880	1.986924e-02	1.702
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.832303e-02	1.737
MAP kinase activation	R-HSA-450294	2.025479e-02	1.693
L1CAM interactions	R-HSA-373760	1.719912e-02	1.764
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.770677e-02	1.752
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.863532e-02	1.730
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.665910e-02	1.778
Signaling by ALK in cancer	R-HSA-9700206	1.665910e-02	1.778
Ion homeostasis	R-HSA-5578775	2.026783e-02	1.693
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.057381e-02	1.687
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.085253e-02	1.681
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.103541e-02	1.677
HDMs demethylate histones	R-HSA-3214842	2.158662e-02	1.666
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	2.184691e-02	1.661
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.210942e-02	1.655
Transcriptional regulation by small RNAs	R-HSA-5578749	2.234811e-02	1.651
Recycling pathway of L1	R-HSA-437239	2.286370e-02	1.641
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.350606e-02	1.629
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.350606e-02	1.629
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.350606e-02	1.629
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.350606e-02	1.629
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.350606e-02	1.629
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.350606e-02	1.629
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.350606e-02	1.629
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.350606e-02	1.629
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.350606e-02	1.629
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.350606e-02	1.629
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.350606e-02	1.629
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.366354e-02	1.626
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.366354e-02	1.626
RAF activation	R-HSA-5673000	2.461650e-02	1.609
NGF-stimulated transcription	R-HSA-9031628	2.619636e-02	1.582
TRP channels	R-HSA-3295583	2.603393e-02	1.584
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.366354e-02	1.626
Nuclear Envelope Breakdown	R-HSA-2980766	2.303865e-02	1.638
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.545347e-02	1.594
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.696168e-02	1.569
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.717077e-02	1.566
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.717077e-02	1.566
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.769865e-02	1.558
Trafficking of AMPA receptors	R-HSA-399719	2.769865e-02	1.558
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.808781e-02	1.551
Activation of RAC1	R-HSA-428540	2.808781e-02	1.551
Reduction of cytosolic Ca++ levels	R-HSA-418359	2.808781e-02	1.551
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.870287e-02	1.542
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.880732e-02	1.540
Cardiac conduction	R-HSA-5576891	2.885163e-02	1.540
Notch-HLH transcription pathway	R-HSA-350054	2.886086e-02	1.540
Cilium Assembly	R-HSA-5617833	2.946200e-02	1.531
Gene expression (Transcription)	R-HSA-74160	2.951752e-02	1.530
ISG15 antiviral mechanism	R-HSA-1169408	3.099083e-02	1.509
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.174006e-02	1.498
Signaling by ROBO receptors	R-HSA-376176	3.257523e-02	1.487
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	3.738456e-02	1.427
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	3.659255e-02	1.437
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.876104e-02	1.412
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.876104e-02	1.412
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.876104e-02	1.412
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.876104e-02	1.412
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	3.480896e-02	1.458
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	3.805498e-02	1.420
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.805498e-02	1.420
RET signaling	R-HSA-8853659	3.349104e-02	1.475
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	3.869382e-02	1.412
Hedgehog 'off' state	R-HSA-5610787	3.504652e-02	1.455
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.777469e-02	1.423
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	3.446017e-02	1.463
Regulation of MECP2 expression and activity	R-HSA-9022692	3.805498e-02	1.420
DAG and IP3 signaling	R-HSA-1489509	3.406909e-02	1.468
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	3.444749e-02	1.463
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	3.876104e-02	1.412
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.876104e-02	1.412
Signaling by NTRKs	R-HSA-166520	3.422971e-02	1.466
Inflammasomes	R-HSA-622312	3.682571e-02	1.434
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.874864e-02	1.412
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.805498e-02	1.420
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.395098e-02	1.469
G1/S Transition	R-HSA-69206	3.953743e-02	1.403
Generic Transcription Pathway	R-HSA-212436	3.981976e-02	1.400
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	4.136013e-02	1.383
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.136013e-02	1.383
MAPK family signaling cascades	R-HSA-5683057	4.137884e-02	1.383
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.154956e-02	1.381
RNA Polymerase II Transcription	R-HSA-73857	4.230527e-02	1.374
Regulation of CDH1 Expression and Function	R-HSA-9764265	4.274971e-02	1.369
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	4.274971e-02	1.369
Neurexins and neuroligins	R-HSA-6794361	4.318928e-02	1.365
Platelet calcium homeostasis	R-HSA-418360	4.324115e-02	1.364
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	4.331474e-02	1.363
Resolution of D-Loop Structures	R-HSA-5693537	4.413346e-02	1.355
Ca-dependent events	R-HSA-111996	4.431389e-02	1.353
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	4.468745e-02	1.350
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.658929e-02	1.332
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.658929e-02	1.332
Organelle biogenesis and maintenance	R-HSA-1852241	4.694792e-02	1.328
Deubiquitination	R-HSA-5688426	4.709780e-02	1.327
Long-term potentiation	R-HSA-9620244	4.911832e-02	1.309
MET activates RAP1 and RAC1	R-HSA-8875555	4.933638e-02	1.307
Apoptosis induced DNA fragmentation	R-HSA-140342	4.933638e-02	1.307
Activation of the pre-replicative complex	R-HSA-68962	5.037668e-02	1.298
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	5.042053e-02	1.297
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.103716e-02	1.292
HATs acetylate histones	R-HSA-3214847	5.114743e-02	1.291
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	5.137920e-02	1.289
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	5.235206e-02	1.281
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.313822e-02	1.200
Ephrin signaling	R-HSA-3928664	6.313822e-02	1.200
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.821432e-02	1.235
Regulation of PD-L1(CD274) expression	R-HSA-9909648	5.721254e-02	1.243
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.821432e-02	1.235
Degradation of beta-catenin by the destruction complex	R-HSA-195253	5.448172e-02	1.264
Polo-like kinase mediated events	R-HSA-156711	6.313822e-02	1.200
Netrin-1 signaling	R-HSA-373752	5.670152e-02	1.246
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	5.396796e-02	1.268
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	5.396796e-02	1.268
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	5.795759e-02	1.237
Interleukin-17 signaling	R-HSA-448424	5.448172e-02	1.264
Transport of connexons to the plasma membrane	R-HSA-190872	6.313822e-02	1.200
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	5.642868e-02	1.249
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	6.369510e-02	1.196
GRB7 events in ERBB2 signaling	R-HSA-1306955	6.384233e-02	1.195
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.669299e-02	1.176
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.669299e-02	1.176
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	6.684880e-02	1.175
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	6.684880e-02	1.175
TRIF-mediated programmed cell death	R-HSA-2562578	6.688035e-02	1.175
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.688035e-02	1.175
MECP2 regulates transcription factors	R-HSA-9022707	6.688035e-02	1.175
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.689992e-02	1.175
G0 and Early G1	R-HSA-1538133	6.689992e-02	1.175
G2/M Checkpoints	R-HSA-69481	6.805111e-02	1.167
DCC mediated attractive signaling	R-HSA-418885	7.122386e-02	1.147
Sema3A PAK dependent Axon repulsion	R-HSA-399954	7.122386e-02	1.147
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	7.122386e-02	1.147
p75NTR signals via NF-kB	R-HSA-193639	7.122386e-02	1.147
Cell-extracellular matrix interactions	R-HSA-446353	7.122386e-02	1.147
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	7.149091e-02	1.146
S Phase	R-HSA-69242	7.245060e-02	1.140
MAP2K and MAPK activation	R-HSA-5674135	7.323961e-02	1.135
Negative regulation of MAPK pathway	R-HSA-5675221	7.323961e-02	1.135
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	7.385818e-02	1.132
Voltage gated Potassium channels	R-HSA-1296072	7.498079e-02	1.125
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	7.631086e-02	1.117
Interactions of Tat with host cellular proteins	R-HSA-176034	7.631086e-02	1.117
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	7.631086e-02	1.117
Regulation of necroptotic cell death	R-HSA-5675482	7.632004e-02	1.117
Activation of ATR in response to replication stress	R-HSA-176187	7.632004e-02	1.117
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	7.632004e-02	1.117
Assembly of the ORC complex at the origin of replication	R-HSA-68616	7.632004e-02	1.117
RAF/MAP kinase cascade	R-HSA-5673001	7.633244e-02	1.117
RNA Polymerase I Promoter Escape	R-HSA-73772	7.661950e-02	1.116
Formation of RNA Pol II elongation complex	R-HSA-112382	7.661950e-02	1.116
G2/M DNA damage checkpoint	R-HSA-69473	7.836556e-02	1.106
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	7.966758e-02	1.099
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.966758e-02	1.099
Sodium/Calcium exchangers	R-HSA-425561	7.966758e-02	1.099
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	9.107694e-02	1.041
SMAC (DIABLO) binds to IAPs	R-HSA-111463	9.107694e-02	1.041
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	9.107694e-02	1.041
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	1.030113e-01	0.987
TRAF6 mediated NF-kB activation	R-HSA-933542	8.895480e-02	1.051
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.021153e-01	0.991
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.814279e-02	1.055
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	9.751515e-02	1.011
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	9.751515e-02	1.011
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	8.800861e-02	1.055
RNA Polymerase II Transcription Elongation	R-HSA-75955	8.467793e-02	1.072
Meiotic synapsis	R-HSA-1221632	8.467793e-02	1.072
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.109982e-02	1.040
mRNA Splicing - Major Pathway	R-HSA-72163	9.949739e-02	1.002
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.440043e-02	1.074
Cyclin E associated events during G1/S transition	R-HSA-69202	8.927705e-02	1.049
Late Phase of HIV Life Cycle	R-HSA-162599	1.008364e-01	0.996
MAPK1/MAPK3 signaling	R-HSA-5684996	1.020738e-01	0.991
HIV Infection	R-HSA-162906	9.120010e-02	1.040
TBC/RABGAPs	R-HSA-8854214	9.131251e-02	1.039
VEGFA-VEGFR2 Pathway	R-HSA-4420097	8.974194e-02	1.047
Membrane Trafficking	R-HSA-199991	8.760092e-02	1.057
Cell junction organization	R-HSA-446728	1.029686e-01	0.987
Cell-Cell communication	R-HSA-1500931	8.602699e-02	1.065
Nephrin family interactions	R-HSA-373753	8.847515e-02	1.053
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.052720e-01	0.978
Neuronal System	R-HSA-112316	1.058949e-01	0.975
Signaling by Hedgehog	R-HSA-5358351	1.059197e-01	0.975
PLC beta mediated events	R-HSA-112043	1.067636e-01	0.972
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.095378e-01	0.960
Signaling by Interleukins	R-HSA-449147	1.100997e-01	0.958
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.105812e-01	0.956
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.106264e-01	0.956
Lipophagy	R-HSA-9613354	1.106264e-01	0.956
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.106264e-01	0.956
Calcineurin activates NFAT	R-HSA-2025928	1.106264e-01	0.956
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.106264e-01	0.956
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.106264e-01	0.956
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.118899e-01	0.951
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.118899e-01	0.951
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.119706e-01	0.951
DNA Replication Pre-Initiation	R-HSA-69002	1.127453e-01	0.948
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.161869e-01	0.935
Heme signaling	R-HSA-9707616	1.161869e-01	0.935
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	1.163005e-01	0.934
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.163005e-01	0.934
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.168373e-01	0.932
Metabolism of RNA	R-HSA-8953854	1.170817e-01	0.932
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.401802e-01	0.853
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.401802e-01	0.853
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.401802e-01	0.853
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.401802e-01	0.853
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.401802e-01	0.853
Regulation of TP53 Expression	R-HSA-6804754	1.232407e-01	0.909
Potassium transport channels	R-HSA-1296067	1.232407e-01	0.909
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	1.222579e-01	0.913
TRAIL signaling	R-HSA-75158	1.222579e-01	0.913
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.222579e-01	0.913
CLEC7A/inflammasome pathway	R-HSA-5660668	1.222579e-01	0.913
IkBA variant leads to EDA-ID	R-HSA-5603029	1.222579e-01	0.913
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	1.222579e-01	0.913
CREB phosphorylation	R-HSA-199920	1.567001e-01	0.805
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	1.567001e-01	0.805
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	1.567001e-01	0.805
Regulation of the apoptosome activity	R-HSA-9627069	1.362523e-01	0.866
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.362523e-01	0.866
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	1.179117e-01	0.928
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.179117e-01	0.928
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	1.179117e-01	0.928
Formation of axial mesoderm	R-HSA-9796292	1.179117e-01	0.928
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.197192e-01	0.922
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.387795e-01	0.858
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.387795e-01	0.858
FGFR2 alternative splicing	R-HSA-6803529	1.356676e-01	0.868
Interaction between L1 and Ankyrins	R-HSA-445095	1.314825e-01	0.881
RNA Polymerase I Promoter Opening	R-HSA-73728	1.314825e-01	0.881
Packaging Of Telomere Ends	R-HSA-171306	1.314825e-01	0.881
Diseases of mitotic cell cycle	R-HSA-9675126	1.267705e-01	0.897
Phase 0 - rapid depolarisation	R-HSA-5576892	1.476240e-01	0.831
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.413687e-01	0.850
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.491641e-01	0.826
mRNA 3'-end processing	R-HSA-72187	1.283523e-01	0.892
Defective pyroptosis	R-HSA-9710421	1.553795e-01	0.809
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.444301e-01	0.840
Homology Directed Repair	R-HSA-5693538	1.522890e-01	0.817
ESR-mediated signaling	R-HSA-8939211	1.403536e-01	0.853
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.536858e-01	0.813
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	1.362523e-01	0.866
Formation of apoptosome	R-HSA-111458	1.362523e-01	0.866
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.395780e-01	0.855
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	1.397498e-01	0.855
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.446731e-01	0.840
Intraflagellar transport	R-HSA-5620924	1.473668e-01	0.832
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.192656e-01	0.923
Apoptotic factor-mediated response	R-HSA-111471	1.387795e-01	0.858
Hedgehog 'on' state	R-HSA-5632684	1.501091e-01	0.824
Synaptic adhesion-like molecules	R-HSA-8849932	1.387795e-01	0.858
Signaling by FGFR1 in disease	R-HSA-5655302	1.290241e-01	0.889
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.491458e-01	0.826
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.314825e-01	0.881
Toll-like Receptor Cascades	R-HSA-168898	1.507457e-01	0.822
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.222579e-01	0.913
Rab regulation of trafficking	R-HSA-9007101	1.441112e-01	0.841
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	R-HSA-180897	1.232407e-01	0.909
CDC6 association with the ORC:origin complex	R-HSA-68689	1.222579e-01	0.913
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	1.567001e-01	0.805
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.179117e-01	0.928
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.267705e-01	0.897
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.555437e-01	0.808
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.187570e-01	0.925
Cytokine Signaling in Immune system	R-HSA-1280215	1.282626e-01	0.892
PI Metabolism	R-HSA-1483255	1.414772e-01	0.849
Reproduction	R-HSA-1474165	1.237441e-01	0.907
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.413687e-01	0.850
MHC class II antigen presentation	R-HSA-2132295	1.446731e-01	0.840
Diseases of DNA repair	R-HSA-9675135	1.231102e-01	0.910
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.387795e-01	0.858
Inositol phosphate metabolism	R-HSA-1483249	1.353232e-01	0.869
Interleukin-12 signaling	R-HSA-9020591	1.422116e-01	0.847
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.567813e-01	0.805
Assembly of the pre-replicative complex	R-HSA-68867	1.573298e-01	0.803
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.573354e-01	0.803
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.607168e-01	0.584
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.607168e-01	0.584
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.607168e-01	0.584
Diseases of Telomere Maintenance	R-HSA-9673013	2.607168e-01	0.584
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.607168e-01	0.584
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.607168e-01	0.584
Defective Mismatch Repair Associated With MSH3	R-HSA-5632927	2.607168e-01	0.584
TICAM1 deficiency - HSE	R-HSA-5602566	2.607168e-01	0.584
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.607168e-01	0.584
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.607168e-01	0.584
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.607168e-01	0.584
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.607168e-01	0.584
MET interacts with TNS proteins	R-HSA-8875513	1.751671e-01	0.757
MET activates PTPN11	R-HSA-8865999	1.751671e-01	0.757
TNFR1-mediated ceramide production	R-HSA-5626978	2.297684e-01	0.639
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.297684e-01	0.639
Defective LFNG causes SCDO3	R-HSA-5083630	2.297684e-01	0.639
Breakdown of the nuclear lamina	R-HSA-352238	3.643616e-01	0.438
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	3.643616e-01	0.438
Mitochondrial transcription initiation	R-HSA-163282	3.643616e-01	0.438
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.643616e-01	0.438
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.643616e-01	0.438
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.643616e-01	0.438
Signaling by TCF7L2 mutants	R-HSA-5339700	3.643616e-01	0.438
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.643616e-01	0.438
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.643616e-01	0.438
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.643616e-01	0.438
TRAF3 deficiency - HSE	R-HSA-5602571	3.643616e-01	0.438
Intestinal infectious diseases	R-HSA-8942233	3.643616e-01	0.438
MyD88 deficiency (TLR5)	R-HSA-5602680	3.643616e-01	0.438
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.643616e-01	0.438
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	3.643616e-01	0.438
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.643616e-01	0.438
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	3.643616e-01	0.438
XAV939 stabilizes AXIN	R-HSA-5545619	3.643616e-01	0.438
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	3.643616e-01	0.438
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	1.936991e-01	0.713
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.936991e-01	0.713
RUNX3 regulates WNT signaling	R-HSA-8951430	1.936991e-01	0.713
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.936991e-01	0.713
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.936991e-01	0.713
SOS-mediated signalling	R-HSA-112412	1.936991e-01	0.713
Cohesin Loading onto Chromatin	R-HSA-2470946	1.936991e-01	0.713
RHOBTB3 ATPase cycle	R-HSA-9706019	1.640118e-01	0.785
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.852751e-01	0.545
IRS activation	R-HSA-74713	2.852751e-01	0.545
NOSIP mediated eNOS trafficking	R-HSA-203754	2.852751e-01	0.545
G2 Phase	R-HSA-68911	2.852751e-01	0.545
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.852751e-01	0.545
ROBO receptors bind AKAP5	R-HSA-9010642	2.325685e-01	0.633
Type I hemidesmosome assembly	R-HSA-446107	2.325685e-01	0.633
Regulation by c-FLIP	R-HSA-3371378	2.325685e-01	0.633
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.325685e-01	0.633
Dimerization of procaspase-8	R-HSA-69416	2.325685e-01	0.633
MET receptor recycling	R-HSA-8875656	2.325685e-01	0.633
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.935906e-01	0.713
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.632035e-01	0.787
E2F mediated regulation of DNA replication	R-HSA-113510	1.591511e-01	0.798
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.880994e-01	0.726
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.246602e-01	0.648
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.246602e-01	0.648
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.246602e-01	0.648
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	2.726650e-01	0.564
Interleukin-21 signaling	R-HSA-9020958	2.726650e-01	0.564
WNT mediated activation of DVL	R-HSA-201688	2.726650e-01	0.564
CASP8 activity is inhibited	R-HSA-5218900	2.726650e-01	0.564
ALK mutants bind TKIs	R-HSA-9700645	2.726650e-01	0.564
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	3.403611e-01	0.468
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	3.403611e-01	0.468
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	3.403611e-01	0.468
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.403611e-01	0.468
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.403611e-01	0.468
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.403611e-01	0.468
Signaling by MAPK mutants	R-HSA-9652817	3.403611e-01	0.468
Signalling to ERK5	R-HSA-198765	4.534809e-01	0.343
Signaling by RAS GAP mutants	R-HSA-9753510	4.534809e-01	0.343
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	4.534809e-01	0.343
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	4.534809e-01	0.343
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.534809e-01	0.343
Essential pentosuria	R-HSA-5662853	4.534809e-01	0.343
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	4.534809e-01	0.343
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.534809e-01	0.343
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.534809e-01	0.343
TWIK related potassium channel (TREK)	R-HSA-1299503	4.534809e-01	0.343
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.142492e-01	0.669
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	2.142492e-01	0.669
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.568899e-01	0.590
Pexophagy	R-HSA-9664873	3.134035e-01	0.504
PI3K/AKT activation	R-HSA-198203	3.134035e-01	0.504
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.134035e-01	0.504
DNA methylation	R-HSA-5334118	1.646788e-01	0.783
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.414554e-01	0.617
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.414554e-01	0.617
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	2.414554e-01	0.617
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.825927e-01	0.739
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.270131e-01	0.644
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.899557e-01	0.538
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	2.899557e-01	0.538
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.899557e-01	0.538
cGMP effects	R-HSA-418457	2.899557e-01	0.538
Removal of the Flap Intermediate	R-HSA-69166	2.899557e-01	0.538
Neurofascin interactions	R-HSA-447043	3.940537e-01	0.404
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.940537e-01	0.404
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	3.940537e-01	0.404
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.729705e-01	0.762
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.639048e-01	0.785
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	2.514593e-01	0.600
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.542658e-01	0.451
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.542658e-01	0.451
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.542658e-01	0.451
HIV Transcription Elongation	R-HSA-167169	1.793211e-01	0.746
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.793211e-01	0.746
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.793211e-01	0.746
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.793211e-01	0.746
EPHA-mediated growth cone collapse	R-HSA-3928663	2.353165e-01	0.628
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.207472e-01	0.656
Spry regulation of FGF signaling	R-HSA-1295596	3.235478e-01	0.490
ERBB2 Regulates Cell Motility	R-HSA-6785631	3.235478e-01	0.490
PRC2 methylates histones and DNA	R-HSA-212300	2.074985e-01	0.683
Nucleosome assembly	R-HSA-774815	1.842311e-01	0.735
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.842311e-01	0.735
HDACs deacetylate histones	R-HSA-3214815	1.644049e-01	0.784
Integrin signaling	R-HSA-354192	2.408489e-01	0.618
Condensation of Prophase Chromosomes	R-HSA-2299718	1.995239e-01	0.700
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.805933e-01	0.552
Late endosomal microautophagy	R-HSA-9615710	2.805933e-01	0.552
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.805933e-01	0.552
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.022704e-01	0.520
Negative regulation of MET activity	R-HSA-6807004	3.274016e-01	0.485
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	3.573761e-01	0.447
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	3.948030e-01	0.404
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	3.948030e-01	0.404
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	3.948030e-01	0.404
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	3.948030e-01	0.404
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.948030e-01	0.404
ERKs are inactivated	R-HSA-202670	3.948030e-01	0.404
Activated NTRK2 signals through CDK5	R-HSA-9032845	4.456614e-01	0.351
MET activates PI3K/AKT signaling	R-HSA-8851907	4.456614e-01	0.351
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	4.456614e-01	0.351
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	4.456614e-01	0.351
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	4.456614e-01	0.351
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	4.456614e-01	0.351
Disinhibition of SNARE formation	R-HSA-114516	4.456614e-01	0.351
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.456614e-01	0.351
Nuclear Receptor transcription pathway	R-HSA-383280	1.630946e-01	0.788
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.177566e-01	0.662
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.647481e-01	0.783
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	1.950244e-01	0.710
Signaling by ERBB2 in Cancer	R-HSA-1227990	3.039966e-01	0.517
ATP-dependent chromatin remodelers	R-HSA-9932444	3.283569e-01	0.484
SWI/SNF chromatin remodelers	R-HSA-9932451	3.283569e-01	0.484
TGFBR3 expression	R-HSA-9839394	3.283569e-01	0.484
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.568385e-01	0.448
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.568385e-01	0.448
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.343232e-01	0.630
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	3.911738e-01	0.408
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.911738e-01	0.408
Regulation of RAS by GAPs	R-HSA-5658442	2.656594e-01	0.576
RNA Polymerase II Transcription Termination	R-HSA-73856	2.495719e-01	0.603
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.982559e-01	0.703
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	3.037957e-01	0.517
Polymerase switching	R-HSA-69091	4.346356e-01	0.362
IRAK1 recruits IKK complex	R-HSA-937039	4.346356e-01	0.362
Leading Strand Synthesis	R-HSA-69109	4.346356e-01	0.362
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	4.346356e-01	0.362
Activation of NF-kappaB in B cells	R-HSA-1169091	2.832343e-01	0.548
G1/S-Specific Transcription	R-HSA-69205	3.262943e-01	0.486
Vif-mediated degradation of APOBEC3G	R-HSA-180585	3.262943e-01	0.486
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	3.242733e-01	0.489
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.200934e-01	0.657
Degradation of AXIN	R-HSA-4641257	3.485135e-01	0.458
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	3.812142e-01	0.419
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	3.812142e-01	0.419
Cristae formation	R-HSA-8949613	3.812142e-01	0.419
PI3K events in ERBB2 signaling	R-HSA-1963642	4.247001e-01	0.372
Elevation of cytosolic Ca2+ levels	R-HSA-139853	4.247001e-01	0.372
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.193284e-01	0.496
mRNA Splicing	R-HSA-72172	1.626237e-01	0.789
Nonsense-Mediated Decay (NMD)	R-HSA-927802	2.528057e-01	0.597
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	2.528057e-01	0.597
Negative regulation of FGFR3 signaling	R-HSA-5654732	4.077283e-01	0.390
Telomere Extension By Telomerase	R-HSA-171319	4.077283e-01	0.390
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.077283e-01	0.390
HIV elongation arrest and recovery	R-HSA-167287	4.077283e-01	0.390
Formation of the Early Elongation Complex	R-HSA-113418	4.077283e-01	0.390
Pausing and recovery of HIV elongation	R-HSA-167290	4.077283e-01	0.390
CD28 dependent Vav1 pathway	R-HSA-389359	4.734499e-01	0.325
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	4.734499e-01	0.325
PKA activation in glucagon signalling	R-HSA-164378	4.577416e-01	0.339
HCMV Early Events	R-HSA-9609690	2.338648e-01	0.631
Negative regulation of FGFR4 signaling	R-HSA-5654733	4.341395e-01	0.362
Dual Incision in GG-NER	R-HSA-5696400	4.245671e-01	0.372
Processing of DNA double-strand break ends	R-HSA-5693607	3.704261e-01	0.431
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	3.462914e-01	0.461
Orc1 removal from chromatin	R-HSA-68949	4.207310e-01	0.376
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.603374e-01	0.337
Degradation of GLI1 by the proteasome	R-HSA-5610780	4.608102e-01	0.336
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.334605e-01	0.363
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.507566e-01	0.346
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.507566e-01	0.346
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.507566e-01	0.346
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.507566e-01	0.346
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.507566e-01	0.346
Formation of a pool of free 40S subunits	R-HSA-72689	4.349274e-01	0.362
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.493397e-01	0.347
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	4.493397e-01	0.347
Signaling by FGFR2	R-HSA-5654738	3.546151e-01	0.450
Signaling by ERBB2	R-HSA-1227986	2.343232e-01	0.630
Co-inhibition by PD-1	R-HSA-389948	1.701696e-01	0.769
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.194601e-01	0.659
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.080667e-01	0.682
Specification of the neural plate border	R-HSA-9834899	2.982309e-01	0.525
DNA Double-Strand Break Repair	R-HSA-5693532	1.760617e-01	0.754
Downregulation of ERBB2 signaling	R-HSA-8863795	3.039966e-01	0.517
Interleukin-9 signaling	R-HSA-8985947	2.325685e-01	0.633
Formation of definitive endoderm	R-HSA-9823730	1.807278e-01	0.743
Chromosome Maintenance	R-HSA-73886	3.092936e-01	0.510
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.257347e-01	0.646
Telomere Maintenance	R-HSA-157579	3.697298e-01	0.432
Germ layer formation at gastrulation	R-HSA-9754189	1.591511e-01	0.798
Degradation of CDH1	R-HSA-9766229	3.610786e-01	0.442
Epigenetic regulation of gene expression	R-HSA-212165	1.726449e-01	0.763
DNA Double Strand Break Response	R-HSA-5693606	3.473931e-01	0.459
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.694385e-01	0.771
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.694385e-01	0.771
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.705389e-01	0.568
Chaperonin-mediated protein folding	R-HSA-390466	3.805484e-01	0.420
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	1.936991e-01	0.713
p75NTR recruits signalling complexes	R-HSA-209543	2.246602e-01	0.648
Activation of SMO	R-HSA-5635838	3.573761e-01	0.447
Transcriptional regulation of testis differentiation	R-HSA-9690406	3.911738e-01	0.408
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	4.247001e-01	0.372
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.610786e-01	0.442
Mismatch Repair	R-HSA-5358508	2.695164e-01	0.569
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.694385e-01	0.771
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.346356e-01	0.362
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	3.948030e-01	0.404
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.911738e-01	0.408
Interleukin-2 family signaling	R-HSA-451927	4.159518e-01	0.381
Rap1 signalling	R-HSA-392517	1.591511e-01	0.798
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.514593e-01	0.600
Processive synthesis on the lagging strand	R-HSA-69183	3.235478e-01	0.490
PKA-mediated phosphorylation of CREB	R-HSA-111931	3.568385e-01	0.448
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.213297e-01	0.655
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	4.170040e-01	0.380
Frs2-mediated activation	R-HSA-170968	2.568899e-01	0.590
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.578461e-01	0.589
Regulation of T cell activation by CD28 family	R-HSA-388841	1.804377e-01	0.744
Circadian clock	R-HSA-9909396	3.142528e-01	0.503
Interleukin-2 signaling	R-HSA-9020558	3.542658e-01	0.451
EGFR Transactivation by Gastrin	R-HSA-2179392	3.134035e-01	0.504
DARPP-32 events	R-HSA-180024	2.805933e-01	0.552
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.603374e-01	0.337
NPAS4 regulates expression of target genes	R-HSA-9768919	2.827234e-01	0.549
Mitophagy	R-HSA-5205647	4.245671e-01	0.372
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.841787e-01	0.735
Protein folding	R-HSA-391251	3.750216e-01	0.426
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.603734e-01	0.795
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.603734e-01	0.795
Cardiogenesis	R-HSA-9733709	2.408489e-01	0.618
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.297684e-01	0.639
Activation of the AP-1 family of transcription factors	R-HSA-450341	2.726650e-01	0.564
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.403611e-01	0.468
Regulation of CDH11 function	R-HSA-9762292	3.134035e-01	0.504
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	2.414554e-01	0.617
Nef Mediated CD4 Down-regulation	R-HSA-167590	4.456614e-01	0.351
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.088310e-01	0.680
SIRT1 negatively regulates rRNA expression	R-HSA-427359	3.485135e-01	0.458
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.159518e-01	0.381
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.384386e-01	0.358
Peptide chain elongation	R-HSA-156902	3.959674e-01	0.402
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.608102e-01	0.336
Switching of origins to a post-replicative state	R-HSA-69052	4.507579e-01	0.346
TNF signaling	R-HSA-75893	1.774600e-01	0.751
Activation of BH3-only proteins	R-HSA-114452	3.039966e-01	0.517
RNA Polymerase I Transcription	R-HSA-73864	2.348902e-01	0.629
Regulation of TNFR1 signaling	R-HSA-5357905	1.995239e-01	0.700
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.591511e-01	0.798
Effects of PIP2 hydrolysis	R-HSA-114508	2.615339e-01	0.582
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.984169e-01	0.702
Eukaryotic Translation Elongation	R-HSA-156842	2.858635e-01	0.544
Interleukin-1 signaling	R-HSA-9020702	2.562191e-01	0.591
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.297684e-01	0.639
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	2.852751e-01	0.545
Adrenoceptors	R-HSA-390696	2.325685e-01	0.633
NF-kB is activated and signals survival	R-HSA-209560	1.935906e-01	0.713
Role of second messengers in netrin-1 signaling	R-HSA-418890	2.246602e-01	0.648
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.793211e-01	0.746
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	3.573761e-01	0.447
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.346356e-01	0.362
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	3.262943e-01	0.486
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.622076e-01	0.581
RNA Polymerase I Transcription Termination	R-HSA-73863	3.812142e-01	0.419
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	4.734499e-01	0.325
PKA activation	R-HSA-163615	4.577416e-01	0.339
IRS-related events triggered by IGF1R	R-HSA-2428928	4.695811e-01	0.328
Opioid Signalling	R-HSA-111885	2.937527e-01	0.532
Response of endothelial cells to shear stress	R-HSA-9860931	1.592393e-01	0.798
Activation of HOX genes during differentiation	R-HSA-5619507	1.685615e-01	0.773
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.685615e-01	0.773
Prolonged ERK activation events	R-HSA-169893	3.573761e-01	0.447
Nuclear RNA decay	R-HSA-9930044	2.408489e-01	0.618
Stabilization of p53	R-HSA-69541	3.934195e-01	0.405
PTEN Regulation	R-HSA-6807070	2.643583e-01	0.578
G-protein mediated events	R-HSA-112040	1.703004e-01	0.769
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.727425e-01	0.763
HIV Life Cycle	R-HSA-162587	2.094720e-01	0.679
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.136482e-01	0.670
Signalling to ERKs	R-HSA-187687	4.487140e-01	0.348
Regulated Necrosis	R-HSA-5218859	2.644118e-01	0.578
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	2.325685e-01	0.633
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.644049e-01	0.784
NoRC negatively regulates rRNA expression	R-HSA-427413	2.213297e-01	0.655
Repression of WNT target genes	R-HSA-4641265	4.346356e-01	0.362
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	4.247001e-01	0.372
Pre-NOTCH Expression and Processing	R-HSA-1912422	4.282762e-01	0.368
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.610368e-01	0.793
Integration of energy metabolism	R-HSA-163685	3.736157e-01	0.428
Gastrulation	R-HSA-9758941	4.647893e-01	0.333
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.638661e-01	0.579
Co-stimulation by CD28	R-HSA-389356	3.413985e-01	0.467
Transcriptional Regulation by NPAS4	R-HSA-9634815	4.207310e-01	0.376
Signaling by Nuclear Receptors	R-HSA-9006931	4.568740e-01	0.340
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	1.751671e-01	0.757
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.403611e-01	0.468
Transcription from mitochondrial promoters	R-HSA-75944	4.534809e-01	0.343
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.568899e-01	0.590
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.899557e-01	0.538
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.408489e-01	0.618
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	4.247001e-01	0.372
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.738321e-01	0.324
rRNA processing in the nucleus and cytosol	R-HSA-8868773	4.713178e-01	0.327
Signaling by NOTCH	R-HSA-157118	4.747177e-01	0.324
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.969677e-01	0.706
Signaling by FGFR in disease	R-HSA-1226099	3.594277e-01	0.444
Signaling by SCF-KIT	R-HSA-1433557	2.469618e-01	0.607
FGFR1 mutant receptor activation	R-HSA-1839124	2.408489e-01	0.618
Regulation of TP53 Degradation	R-HSA-6804757	3.262943e-01	0.486
Regulation of KIT signaling	R-HSA-1433559	2.899557e-01	0.538
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	3.573761e-01	0.447
Cellular responses to mechanical stimuli	R-HSA-9855142	2.762075e-01	0.559
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.872087e-01	0.728
MTOR signalling	R-HSA-165159	3.450053e-01	0.462
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	4.504529e-01	0.346
Transcriptional Regulation by VENTX	R-HSA-8853884	1.953769e-01	0.709
Protein-protein interactions at synapses	R-HSA-6794362	1.754479e-01	0.756
FasL/ CD95L signaling	R-HSA-75157	1.751671e-01	0.757
Formation of intermediate mesoderm	R-HSA-9761174	3.134035e-01	0.504
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	3.542658e-01	0.451
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	3.948030e-01	0.404
Regulation of PTEN gene transcription	R-HSA-8943724	2.343232e-01	0.630
Potassium Channels	R-HSA-1296071	1.984169e-01	0.702
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.450063e-01	0.352
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	4.245671e-01	0.372
Transmission across Chemical Synapses	R-HSA-112315	3.976339e-01	0.401
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.153509e-01	0.667
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.855034e-01	0.732
COPI-mediated anterograde transport	R-HSA-6807878	3.554006e-01	0.449
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.269300e-01	0.486
ERK/MAPK targets	R-HSA-198753	2.033911e-01	0.692
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.760264e-01	0.425
Signaling by VEGF	R-HSA-194138	1.694385e-01	0.771
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.932855e-01	0.714
Signaling by PTK6	R-HSA-8848021	1.932855e-01	0.714
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	4.291837e-01	0.367
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	4.291837e-01	0.367
Cleavage of the damaged purine	R-HSA-110331	2.257347e-01	0.646
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.603374e-01	0.337
MAPK6/MAPK4 signaling	R-HSA-5687128	2.475466e-01	0.606
Cell-cell junction organization	R-HSA-421270	2.808442e-01	0.552
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	1.932855e-01	0.714
Adherens junctions interactions	R-HSA-418990	2.185637e-01	0.660
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.805933e-01	0.552
Transcriptional regulation by RUNX3	R-HSA-8878159	2.834541e-01	0.548
Gluconeogenesis	R-HSA-70263	3.413985e-01	0.467
Depurination	R-HSA-73927	2.445441e-01	0.612
Interleukin-1 family signaling	R-HSA-446652	2.800341e-01	0.553
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.384386e-01	0.358
Formation of editosomes by ADAR proteins	R-HSA-77042	2.607168e-01	0.584
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.751671e-01	0.757
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.751671e-01	0.757
Manipulation of host energy metabolism	R-HSA-9636667	3.643616e-01	0.438
Regulation of PTEN localization	R-HSA-8948747	1.936991e-01	0.713
Cation-coupled Chloride cotransporters	R-HSA-426117	1.936991e-01	0.713
Phase 3 - rapid repolarisation	R-HSA-5576890	1.936991e-01	0.713
NrCAM interactions	R-HSA-447038	2.852751e-01	0.545
mRNA Editing: A to I Conversion	R-HSA-75064	4.534809e-01	0.343
Influenza Virus Induced Apoptosis	R-HSA-168277	4.534809e-01	0.343
C6 deamination of adenosine	R-HSA-75102	4.534809e-01	0.343
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.534809e-01	0.343
Regulation of cortical dendrite branching	R-HSA-8985801	4.534809e-01	0.343
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.568899e-01	0.590
Viral Messenger RNA Synthesis	R-HSA-168325	1.676656e-01	0.776
Phase 4 - resting membrane potential	R-HSA-5576886	3.573761e-01	0.447
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.923880e-01	0.716
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	4.048874e-01	0.393
RUNX2 regulates bone development	R-HSA-8941326	4.726658e-01	0.325
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.760264e-01	0.425
FLT3 Signaling	R-HSA-9607240	3.037957e-01	0.517
FLT3 signaling in disease	R-HSA-9682385	3.262943e-01	0.486
Regulation of PTEN stability and activity	R-HSA-8948751	3.193284e-01	0.496
Signaling by ERBB4	R-HSA-1236394	3.594277e-01	0.444
Interferon Signaling	R-HSA-913531	2.353357e-01	0.628
Signal transduction by L1	R-HSA-445144	3.274016e-01	0.485
UCH proteinases	R-HSA-5689603	3.924246e-01	0.406
NOD1/2 Signaling Pathway	R-HSA-168638	4.245671e-01	0.372
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	4.423202e-01	0.354
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.644373e-01	0.438
Signaling by NTRK2 (TRKB)	R-HSA-9006115	3.812142e-01	0.419
Oncogene Induced Senescence	R-HSA-2559585	4.487140e-01	0.348
Nef and signal transduction	R-HSA-164944	3.940537e-01	0.404
LGI-ADAM interactions	R-HSA-5682910	3.542658e-01	0.451
CHL1 interactions	R-HSA-447041	4.456614e-01	0.351
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.951775e-01	0.530
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.080777e-01	0.389
Cargo trafficking to the periciliary membrane	R-HSA-5620920	4.161463e-01	0.381
Gap junction trafficking and regulation	R-HSA-157858	3.610786e-01	0.442
Formation of the nephric duct	R-HSA-9830364	3.283569e-01	0.484
SARS-CoV-2-host interactions	R-HSA-9705683	4.215708e-01	0.375
Maturation of nucleoprotein	R-HSA-9694631	2.982309e-01	0.525
Signaling by ALK	R-HSA-201556	2.638661e-01	0.579
Base Excision Repair	R-HSA-73884	4.269522e-01	0.370
Zygotic genome activation (ZGA)	R-HSA-9819196	3.568385e-01	0.448
Interleukin-6 signaling	R-HSA-1059683	4.734499e-01	0.325
DSCAM interactions	R-HSA-376172	4.534809e-01	0.343
Tandem pore domain potassium channels	R-HSA-1296346	3.134035e-01	0.504
OAS antiviral response	R-HSA-8983711	4.346356e-01	0.362
Maturation of nucleoprotein	R-HSA-9683610	4.734499e-01	0.325
Regulation of gene expression in beta cells	R-HSA-210745	4.341395e-01	0.362
Mitochondrial biogenesis	R-HSA-1592230	4.217042e-01	0.375
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.711611e-01	0.327
Sensory processing of sound	R-HSA-9659379	4.423202e-01	0.354
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	4.734499e-01	0.325
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	4.734499e-01	0.325
Gap junction trafficking	R-HSA-190828	3.869714e-01	0.412
Ion transport by P-type ATPases	R-HSA-936837	4.056612e-01	0.392
MITF-M-dependent gene expression	R-HSA-9856651	2.597562e-01	0.585
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.534809e-01	0.343
Displacement of DNA glycosylase by APEX1	R-HSA-110357	4.456614e-01	0.351
Gap junction assembly	R-HSA-190861	2.827234e-01	0.549
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	3.751415e-01	0.426
Base-Excision Repair, AP Site Formation	R-HSA-73929	4.604909e-01	0.337
Nephron development	R-HSA-9831926	2.695164e-01	0.569
Interleukin-12 family signaling	R-HSA-447115	2.095909e-01	0.679
PKR-mediated signaling	R-HSA-9833482	1.855034e-01	0.732
Metal ion SLC transporters	R-HSA-425410	4.711611e-01	0.327
Specification of primordial germ cells	R-HSA-9827857	4.247001e-01	0.372
Influenza Infection	R-HSA-168255	3.082679e-01	0.511
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	2.852751e-01	0.545
Regulated proteolysis of p75NTR	R-HSA-193692	2.726650e-01	0.564
Interleukin-1 processing	R-HSA-448706	2.726650e-01	0.564
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.403611e-01	0.468
Uptake and function of diphtheria toxin	R-HSA-5336415	4.456614e-01	0.351
Cleavage of the damaged pyrimidine	R-HSA-110329	3.450053e-01	0.462
Depyrimidination	R-HSA-73928	3.450053e-01	0.462
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.729705e-01	0.762
tRNA processing in the nucleus	R-HSA-6784531	2.651761e-01	0.576
Gene Silencing by RNA	R-HSA-211000	1.982206e-01	0.703
Interleukin-37 signaling	R-HSA-9008059	1.825927e-01	0.739
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	4.755051e-01	0.323
TCR signaling	R-HSA-202403	4.776547e-01	0.321
Transcription of the HIV genome	R-HSA-167172	4.777497e-01	0.321
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	4.830008e-01	0.316
RNA Polymerase I Transcription Initiation	R-HSA-73762	4.830008e-01	0.316
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.830008e-01	0.316
DNA Repair	R-HSA-73894	4.856938e-01	0.314
EGFR downregulation	R-HSA-182971	4.862207e-01	0.313
Downstream signal transduction	R-HSA-186763	4.862207e-01	0.313
IKK complex recruitment mediated by RIP1	R-HSA-937041	4.901124e-01	0.310
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.901124e-01	0.310
Signaling by FGFR2 IIIa TM	R-HSA-8851708	4.901124e-01	0.310
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	4.947135e-01	0.306
Regulation of NPAS4 mRNA translation	R-HSA-9768778	4.947135e-01	0.306
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.947135e-01	0.306
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.947135e-01	0.306
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.947135e-01	0.306
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.947135e-01	0.306
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	4.947135e-01	0.306
Co-stimulation by ICOS	R-HSA-9927354	4.947135e-01	0.306
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	4.963451e-01	0.304
Ovarian tumor domain proteases	R-HSA-5689896	4.963451e-01	0.304
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	4.997925e-01	0.301
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.021541e-01	0.299
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.021541e-01	0.299
Interleukin-7 signaling	R-HSA-1266695	5.021541e-01	0.299
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	5.021541e-01	0.299
Signaling by NOTCH1	R-HSA-1980143	5.022340e-01	0.299
Signaling by FGFR4	R-HSA-5654743	5.049490e-01	0.297
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.068511e-01	0.295
NRIF signals cell death from the nucleus	R-HSA-205043	5.109943e-01	0.292
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.109943e-01	0.292
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.109943e-01	0.292
CRMPs in Sema3A signaling	R-HSA-399956	5.109943e-01	0.292
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	5.109943e-01	0.292
Signaling by FGFR4 in disease	R-HSA-5655291	5.109943e-01	0.292
Physiological factors	R-HSA-5578768	5.109943e-01	0.292
P2Y receptors	R-HSA-417957	5.109943e-01	0.292
PI3K Cascade	R-HSA-109704	5.124639e-01	0.290
DNA Replication	R-HSA-69306	5.127980e-01	0.290
Platelet homeostasis	R-HSA-418346	5.148310e-01	0.288
Signaling by TGFB family members	R-HSA-9006936	5.169960e-01	0.287
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	5.191545e-01	0.285
Regulation of CDH1 Function	R-HSA-9764561	5.191614e-01	0.285
IRS-mediated signalling	R-HSA-112399	5.191614e-01	0.285
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	5.193786e-01	0.285
MET promotes cell motility	R-HSA-8875878	5.196805e-01	0.284
Regulation of PD-L1(CD274) translation	R-HSA-9909620	5.216537e-01	0.283
Co-inhibition by CTLA4	R-HSA-389513	5.216537e-01	0.283
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	5.216537e-01	0.283
Creatine metabolism	R-HSA-71288	5.216537e-01	0.283
IGF1R signaling cascade	R-HSA-2428924	5.252227e-01	0.280
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	5.265975e-01	0.279
G1 Phase	R-HSA-69236	5.265975e-01	0.279
Cyclin D associated events in G1	R-HSA-69231	5.265975e-01	0.279
Signaling by EGFR in Cancer	R-HSA-1643713	5.298613e-01	0.276
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	5.298613e-01	0.276
Myogenesis	R-HSA-525793	5.298613e-01	0.276
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	5.298613e-01	0.276
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	5.298613e-01	0.276
The IPAF inflammasome	R-HSA-844623	5.301097e-01	0.276
Axonal growth stimulation	R-HSA-209563	5.301097e-01	0.276
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	5.301097e-01	0.276
Phenylketonuria	R-HSA-2160456	5.301097e-01	0.276
Defective GCLC causes HAGGSD	R-HSA-5578999	5.301097e-01	0.276
Invadopodia formation	R-HSA-8941237	5.301097e-01	0.276
Defective CYP1B1 causes Glaucoma	R-HSA-5579000	5.301097e-01	0.276
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.301097e-01	0.276
IRAK4 deficiency (TLR5)	R-HSA-5603037	5.301097e-01	0.276
Defective CYP7B1 causes SPG5A and CBAS3	R-HSA-5579013	5.301097e-01	0.276
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.301097e-01	0.276
MET activates STAT3	R-HSA-8875791	5.301097e-01	0.276
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	5.301097e-01	0.276
Activation of BMF and translocation to mitochondria	R-HSA-139910	5.301097e-01	0.276
Intracellular oxygen transport	R-HSA-8981607	5.301097e-01	0.276
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.307746e-01	0.275
Regulation of mitotic cell cycle	R-HSA-453276	5.307746e-01	0.275
G-protein beta:gamma signalling	R-HSA-397795	5.366838e-01	0.270
Negative regulation of FGFR1 signaling	R-HSA-5654726	5.366838e-01	0.270
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	5.366838e-01	0.270
Transcriptional regulation by RUNX2	R-HSA-8878166	5.378257e-01	0.269
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	5.409122e-01	0.267
Inactivation of CDC42 and RAC1	R-HSA-428543	5.409122e-01	0.267
MASTL Facilitates Mitotic Progression	R-HSA-2465910	5.409122e-01	0.267
p75NTR regulates axonogenesis	R-HSA-193697	5.409122e-01	0.267
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	5.409122e-01	0.267
mRNA Editing	R-HSA-75072	5.409122e-01	0.267
ARMS-mediated activation	R-HSA-170984	5.409122e-01	0.267
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	5.409122e-01	0.267
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	5.409122e-01	0.267
Regulation of CDH11 gene transcription	R-HSA-9762293	5.409122e-01	0.267
Respiratory syncytial virus genome replication	R-HSA-9834752	5.409122e-01	0.267
Butyrophilin (BTN) family interactions	R-HSA-8851680	5.409122e-01	0.267
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	5.426073e-01	0.266
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	5.433729e-01	0.265
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	5.451866e-01	0.263
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.470730e-01	0.262
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.470730e-01	0.262
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	5.470730e-01	0.262
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.470730e-01	0.262
Telomere C-strand synthesis initiation	R-HSA-174430	5.470730e-01	0.262
Protein methylation	R-HSA-8876725	5.470730e-01	0.262
Formation of the anterior neural plate	R-HSA-9823739	5.470730e-01	0.262
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.470730e-01	0.262
Signaling by FGFR3	R-HSA-5654741	5.478942e-01	0.261
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.478942e-01	0.261
Fanconi Anemia Pathway	R-HSA-6783310	5.478942e-01	0.261
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	5.478942e-01	0.261
Somitogenesis	R-HSA-9824272	5.478942e-01	0.261
Cellular response to chemical stress	R-HSA-9711123	5.510080e-01	0.259
Lagging Strand Synthesis	R-HSA-69186	5.522332e-01	0.258
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	5.527032e-01	0.258
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.527032e-01	0.258
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.568576e-01	0.254
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.568576e-01	0.254
CD28 dependent PI3K/Akt signaling	R-HSA-389357	5.568576e-01	0.254
Extension of Telomeres	R-HSA-180786	5.571380e-01	0.254
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.611073e-01	0.251
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.611073e-01	0.251
Miscellaneous transport and binding events	R-HSA-5223345	5.611073e-01	0.251
Developmental Biology	R-HSA-1266738	5.639399e-01	0.249
Diseases of Immune System	R-HSA-5260271	5.650671e-01	0.248
Diseases associated with the TLR signaling cascade	R-HSA-5602358	5.650671e-01	0.248
Ca2+ pathway	R-HSA-4086398	5.651514e-01	0.248
mRNA Splicing - Minor Pathway	R-HSA-72165	5.687912e-01	0.245
Signaling by MET	R-HSA-6806834	5.688206e-01	0.245
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	5.688206e-01	0.245
HCMV Infection	R-HSA-9609646	5.703034e-01	0.244
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	5.710069e-01	0.243
Cellular response to starvation	R-HSA-9711097	5.714528e-01	0.243
Kidney development	R-HSA-9830369	5.788851e-01	0.237
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	5.800717e-01	0.237
Phosphorylation of the APC/C	R-HSA-176412	5.815404e-01	0.235
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.815404e-01	0.235
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.815404e-01	0.235
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.815404e-01	0.235
Regulation of NF-kappa B signaling	R-HSA-9758274	5.815404e-01	0.235
Negative regulation of FLT3	R-HSA-9706369	5.815404e-01	0.235
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.817433e-01	0.235
Signaling by PDGFR in disease	R-HSA-9671555	5.817433e-01	0.235
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	5.817433e-01	0.235
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	5.830618e-01	0.234
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	5.830618e-01	0.234
Folding of actin by CCT/TriC	R-HSA-390450	5.840934e-01	0.234
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	5.840934e-01	0.234
Arachidonate production from DAG	R-HSA-426048	5.840934e-01	0.234
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	5.840934e-01	0.234
Signal attenuation	R-HSA-74749	5.840934e-01	0.234
Receptor Mediated Mitophagy	R-HSA-8934903	5.840934e-01	0.234
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	5.840934e-01	0.234
Signaling by Leptin	R-HSA-2586552	5.840934e-01	0.234
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.849038e-01	0.233
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.849038e-01	0.233
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	5.849038e-01	0.233
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	5.870085e-01	0.231
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	5.870085e-01	0.231
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.870085e-01	0.231
Eukaryotic Translation Initiation	R-HSA-72613	5.876942e-01	0.231
Cap-dependent Translation Initiation	R-HSA-72737	5.876942e-01	0.231
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	5.892459e-01	0.230
FOXO-mediated transcription	R-HSA-9614085	5.932407e-01	0.227
Regulation of RUNX2 expression and activity	R-HSA-8939902	5.938689e-01	0.226
HCN channels	R-HSA-1296061	5.959980e-01	0.225
AKT-mediated inactivation of FOXO1A	R-HSA-211163	5.959980e-01	0.225
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	5.959980e-01	0.225
ATP sensitive Potassium channels	R-HSA-1296025	5.959980e-01	0.225
Signaling by MAP2K mutants	R-HSA-9652169	5.959980e-01	0.225
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.959980e-01	0.225
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	5.959980e-01	0.225
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	5.959980e-01	0.225
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	5.959980e-01	0.225
Regulation of gap junction activity	R-HSA-191650	5.959980e-01	0.225
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.959980e-01	0.225
Electric Transmission Across Gap Junctions	R-HSA-112303	5.959980e-01	0.225
Transmission across Electrical Synapses	R-HSA-112307	5.959980e-01	0.225
Alanine metabolism	R-HSA-8964540	5.959980e-01	0.225
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.959980e-01	0.225
MDK and PTN in ALK signaling	R-HSA-9851151	5.959980e-01	0.225
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.959980e-01	0.225
Dopamine receptors	R-HSA-390651	5.959980e-01	0.225
FLT3 signaling through SRC family kinases	R-HSA-9706374	5.959980e-01	0.225
Interleukin-38 signaling	R-HSA-9007892	5.959980e-01	0.225
MITF-M-regulated melanocyte development	R-HSA-9730414	6.031007e-01	0.220
Signaling by Erythropoietin	R-HSA-9006335	6.084060e-01	0.216
mRNA Capping	R-HSA-72086	6.084060e-01	0.216
Termination of translesion DNA synthesis	R-HSA-5656169	6.084060e-01	0.216
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	6.084060e-01	0.216
Regulation of IFNA/IFNB signaling	R-HSA-912694	6.100996e-01	0.215
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	6.100996e-01	0.215
mTORC1-mediated signalling	R-HSA-166208	6.100996e-01	0.215
RAF-independent MAPK1/3 activation	R-HSA-112409	6.100996e-01	0.215
Signaling by KIT in disease	R-HSA-9669938	6.100996e-01	0.215
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	6.100996e-01	0.215
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.103558e-01	0.214
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.142952e-01	0.212
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.142952e-01	0.212
Phase 2 - plateau phase	R-HSA-5576893	6.142952e-01	0.212
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	6.142952e-01	0.212
TRAF3-dependent IRF activation pathway	R-HSA-918233	6.142952e-01	0.212
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	6.142952e-01	0.212
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	6.142952e-01	0.212
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.142952e-01	0.212
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	6.142952e-01	0.212
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	6.197163e-01	0.208
Beta-catenin independent WNT signaling	R-HSA-3858494	6.198721e-01	0.208
Selenocysteine synthesis	R-HSA-2408557	6.214275e-01	0.207
Synthesis of DNA	R-HSA-69239	6.231467e-01	0.205
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	6.241950e-01	0.205
Formation of the posterior neural plate	R-HSA-9832991	6.241950e-01	0.205
Ionotropic activity of kainate receptors	R-HSA-451306	6.241950e-01	0.205
Synthesis of PI	R-HSA-1483226	6.241950e-01	0.205
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	6.287183e-01	0.202
Signaling by EGFR	R-HSA-177929	6.287183e-01	0.202
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	6.297791e-01	0.201
Adipogenesis	R-HSA-9843745	6.300045e-01	0.201
Triglyceride catabolism	R-HSA-163560	6.304055e-01	0.200
Downstream TCR signaling	R-HSA-202424	6.327336e-01	0.199
Eukaryotic Translation Termination	R-HSA-72764	6.339208e-01	0.198
Regulation of endogenous retroelements	R-HSA-9842860	6.351708e-01	0.197
Stimuli-sensing channels	R-HSA-2672351	6.364688e-01	0.196
Interleukin receptor SHC signaling	R-HSA-912526	6.372390e-01	0.196
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	6.372390e-01	0.196
Syndecan interactions	R-HSA-3000170	6.372390e-01	0.196
Growth hormone receptor signaling	R-HSA-982772	6.372390e-01	0.196
Ribosome-associated quality control	R-HSA-9948299	6.433528e-01	0.192
Uptake and function of anthrax toxins	R-HSA-5210891	6.452741e-01	0.190
Insulin receptor signalling cascade	R-HSA-74751	6.461261e-01	0.190
Degradation of DVL	R-HSA-4641258	6.520278e-01	0.186
Platelet degranulation	R-HSA-114608	6.525974e-01	0.185
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	6.526506e-01	0.185
FLT3 signaling by CBL mutants	R-HSA-9706377	6.526506e-01	0.185
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	6.526506e-01	0.185
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	6.526506e-01	0.185
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	6.526506e-01	0.185
PTK6 Down-Regulation	R-HSA-8849472	6.526506e-01	0.185
Post-transcriptional silencing by small RNAs	R-HSA-426496	6.526506e-01	0.185
Activation of C3 and C5	R-HSA-174577	6.526506e-01	0.185
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	6.526506e-01	0.185
Muscarinic acetylcholine receptors	R-HSA-390648	6.526506e-01	0.185
Inositol transporters	R-HSA-429593	6.526506e-01	0.185
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	6.526506e-01	0.185
Budding and maturation of HIV virion	R-HSA-162588	6.563104e-01	0.183
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	6.563104e-01	0.183
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	6.612315e-01	0.180
Condensation of Prometaphase Chromosomes	R-HSA-2514853	6.612315e-01	0.180
Sensing of DNA Double Strand Breaks	R-HSA-5693548	6.612315e-01	0.180
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	6.612315e-01	0.180
Deadenylation of mRNA	R-HSA-429947	6.631177e-01	0.178
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.631177e-01	0.178
Complex III assembly	R-HSA-9865881	6.631177e-01	0.178
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	6.631177e-01	0.178
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.721774e-01	0.173
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	6.744464e-01	0.171
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.744464e-01	0.171
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.744464e-01	0.171
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.744464e-01	0.171
Depolymerization of the Nuclear Lamina	R-HSA-4419969	6.744464e-01	0.171
Nucleotide-like (purinergic) receptors	R-HSA-418038	6.744464e-01	0.171
Platelet sensitization by LDL	R-HSA-432142	6.744464e-01	0.171
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.744464e-01	0.171
Signaling by FGFR	R-HSA-190236	6.748827e-01	0.171
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.755281e-01	0.170
DNA strand elongation	R-HSA-69190	6.787981e-01	0.168
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	6.787981e-01	0.168
Deadenylation-dependent mRNA decay	R-HSA-429914	6.808891e-01	0.167
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	6.837200e-01	0.165
Uptake and actions of bacterial toxins	R-HSA-5339562	6.837200e-01	0.165
Tight junction interactions	R-HSA-420029	6.877089e-01	0.163
Ion channel transport	R-HSA-983712	6.920982e-01	0.160
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	6.928686e-01	0.159
MET activates RAS signaling	R-HSA-8851805	6.952739e-01	0.158
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	6.952739e-01	0.158
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	6.952739e-01	0.158
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	6.952739e-01	0.158
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.952739e-01	0.158
Scavenging by Class F Receptors	R-HSA-3000484	6.952739e-01	0.158
Interleukin-15 signaling	R-HSA-8983432	6.952739e-01	0.158
Regulation of IFNG signaling	R-HSA-877312	6.952739e-01	0.158
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.952739e-01	0.158
GRB2 events in EGFR signaling	R-HSA-179812	6.952739e-01	0.158
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	6.952739e-01	0.158
Estrogen biosynthesis	R-HSA-193144	6.952739e-01	0.158
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.008861e-01	0.154
Golgi Associated Vesicle Biogenesis	R-HSA-432722	7.008861e-01	0.154
Plus-strand DNA synthesis	R-HSA-164525	7.013617e-01	0.154
Nef Mediated CD8 Down-regulation	R-HSA-182218	7.013617e-01	0.154
Noncanonical activation of NOTCH3	R-HSA-9017802	7.013617e-01	0.154
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	7.013617e-01	0.154
PKB-mediated events	R-HSA-109703	7.013617e-01	0.154
PDE3B signalling	R-HSA-165160	7.013617e-01	0.154
PTK6 Regulates Cell Cycle	R-HSA-8849470	7.013617e-01	0.154
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	7.013617e-01	0.154
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	7.013617e-01	0.154
Defective CSF2RB causes SMDP5	R-HSA-5688849	7.013617e-01	0.154
Defective CSF2RA causes SMDP4	R-HSA-5688890	7.013617e-01	0.154
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	7.013617e-01	0.154
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	7.013617e-01	0.154
Signaling by RNF43 mutants	R-HSA-5340588	7.013617e-01	0.154
Pentose phosphate pathway disease	R-HSA-6791465	7.013617e-01	0.154
Phosphorylation of Emi1	R-HSA-176417	7.013617e-01	0.154
Formation of the Editosome	R-HSA-75094	7.013617e-01	0.154
Synthesis of PS	R-HSA-1483101	7.013617e-01	0.154
Signalling to p38 via RIT and RIN	R-HSA-187706	7.013617e-01	0.154
Release of apoptotic factors from the mitochondria	R-HSA-111457	7.013617e-01	0.154
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	7.013617e-01	0.154
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	7.013617e-01	0.154
Mitochondrial protein degradation	R-HSA-9837999	7.017360e-01	0.154
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.018087e-01	0.154
PI-3K cascade:FGFR3	R-HSA-5654710	7.018087e-01	0.154
STING mediated induction of host immune responses	R-HSA-1834941	7.018087e-01	0.154
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.056716e-01	0.151
Signaling by TGFBR3	R-HSA-9839373	7.056716e-01	0.151
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.069122e-01	0.151
HCMV Late Events	R-HSA-9610379	7.092936e-01	0.149
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.110013e-01	0.148
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.110013e-01	0.148
Nuclear signaling by ERBB4	R-HSA-1251985	7.120508e-01	0.147
Generation of second messenger molecules	R-HSA-202433	7.120508e-01	0.147
Regulation of RUNX3 expression and activity	R-HSA-8941858	7.120508e-01	0.147
Formation of paraxial mesoderm	R-HSA-9793380	7.130665e-01	0.147
Platelet activation, signaling and aggregation	R-HSA-76002	7.173770e-01	0.144
DNA Damage Recognition in GG-NER	R-HSA-5696394	7.207436e-01	0.142
Vpu mediated degradation of CD4	R-HSA-180534	7.207436e-01	0.142
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	7.230594e-01	0.141
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.230594e-01	0.141
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	7.238371e-01	0.140
Acetylcholine binding and downstream events	R-HSA-181431	7.264335e-01	0.139
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	7.264335e-01	0.139
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	7.264335e-01	0.139
Reversible hydration of carbon dioxide	R-HSA-1475029	7.264335e-01	0.139
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.273802e-01	0.138
PI-3K cascade:FGFR4	R-HSA-5654720	7.273802e-01	0.138
Signaling by NODAL	R-HSA-1181150	7.273802e-01	0.138
Protein hydroxylation	R-HSA-9629569	7.273802e-01	0.138
Vesicle-mediated transport	R-HSA-5653656	7.278881e-01	0.138
Mitochondrial protein import	R-HSA-1268020	7.283396e-01	0.138
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.283396e-01	0.138
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	7.316799e-01	0.136
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	7.329965e-01	0.135
Signaling by FGFR3 in disease	R-HSA-5655332	7.329965e-01	0.135
Viral mRNA Translation	R-HSA-192823	7.370754e-01	0.132
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.401890e-01	0.131
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	7.432442e-01	0.129
STAT5 Activation	R-HSA-9645135	7.432442e-01	0.129
Erythropoietin activates STAT5	R-HSA-9027283	7.432442e-01	0.129
Uncoating of the HIV Virion	R-HSA-162585	7.432442e-01	0.129
Hydrolysis of LPE	R-HSA-1483152	7.432442e-01	0.129
MET Receptor Activation	R-HSA-6806942	7.432442e-01	0.129
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	7.432442e-01	0.129
G2/M DNA replication checkpoint	R-HSA-69478	7.432442e-01	0.129
Abacavir transmembrane transport	R-HSA-2161517	7.432442e-01	0.129
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	7.432442e-01	0.129
CREB3 factors activate genes	R-HSA-8874211	7.432442e-01	0.129
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.478975e-01	0.126
Degradation of CRY and PER proteins	R-HSA-9932298	7.478975e-01	0.126
PCP/CE pathway	R-HSA-4086400	7.480084e-01	0.126
Neutrophil degranulation	R-HSA-6798695	7.485474e-01	0.126
Signaling by FGFR1	R-HSA-5654736	7.486811e-01	0.126
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	7.511982e-01	0.124
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.511982e-01	0.124
Signalling to RAS	R-HSA-167044	7.511982e-01	0.124
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.511982e-01	0.124
Basigin interactions	R-HSA-210991	7.511982e-01	0.124
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.511982e-01	0.124
Pyroptosis	R-HSA-5620971	7.537077e-01	0.123
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	7.548493e-01	0.122
Zinc transporters	R-HSA-435354	7.548493e-01	0.122
SARS-CoV-2 Infection	R-HSA-9694516	7.573951e-01	0.121
PERK regulates gene expression	R-HSA-381042	7.586211e-01	0.120
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	7.586211e-01	0.120
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	7.586211e-01	0.120
Regulation of Apoptosis	R-HSA-169911	7.586211e-01	0.120
XBP1(S) activates chaperone genes	R-HSA-381038	7.689626e-01	0.114
Nucleotide Excision Repair	R-HSA-5696398	7.704785e-01	0.113
Cellular response to hypoxia	R-HSA-1234174	7.708355e-01	0.113
Signaling by FGFR2 in disease	R-HSA-5655253	7.709278e-01	0.113
Downstream signaling of activated FGFR3	R-HSA-5654708	7.731575e-01	0.112
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.733145e-01	0.112
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.733145e-01	0.112
Dual incision in TC-NER	R-HSA-6782135	7.774219e-01	0.109
Clathrin-mediated endocytosis	R-HSA-8856828	7.778017e-01	0.109
Netrin mediated repulsion signals	R-HSA-418886	7.792549e-01	0.108
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.792549e-01	0.108
PTK6 Expression	R-HSA-8849473	7.792549e-01	0.108
Recycling of eIF2:GDP	R-HSA-72731	7.792549e-01	0.108
DAG1 core M1 glycosylations	R-HSA-8932506	7.792549e-01	0.108
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	7.792549e-01	0.108
mRNA Editing: C to U Conversion	R-HSA-72200	7.792549e-01	0.108
Activated NTRK3 signals through PI3K	R-HSA-9603381	7.792549e-01	0.108
Ca2+ activated K+ channels	R-HSA-1296052	7.792549e-01	0.108
VLDL clearance	R-HSA-8964046	7.792549e-01	0.108
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	7.792549e-01	0.108
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)	R-HSA-9026762	7.792549e-01	0.108
Maturation of replicase proteins	R-HSA-9694301	7.792549e-01	0.108
Hh mutants abrogate ligand secretion	R-HSA-5387390	7.803971e-01	0.108
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	7.806778e-01	0.108
Erythropoietin activates RAS	R-HSA-9027284	7.806778e-01	0.108
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	7.806778e-01	0.108
SHC1 events in EGFR signaling	R-HSA-180336	7.806778e-01	0.108
p38MAPK events	R-HSA-171007	7.806778e-01	0.108
Biotin transport and metabolism	R-HSA-196780	7.806778e-01	0.108
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	7.806778e-01	0.108
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	7.806778e-01	0.108
Other semaphorin interactions	R-HSA-416700	7.806778e-01	0.108
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	7.806778e-01	0.108
C-type lectin receptors (CLRs)	R-HSA-5621481	7.812818e-01	0.107
Regulation of beta-cell development	R-HSA-186712	7.908606e-01	0.102
Downstream signaling of activated FGFR4	R-HSA-5654716	7.913766e-01	0.102
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.937921e-01	0.100
PI-3K cascade:FGFR1	R-HSA-5654689	7.937921e-01	0.100
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.937921e-01	0.100
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.937921e-01	0.100
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.937921e-01	0.100
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.937921e-01	0.100
Extra-nuclear estrogen signaling	R-HSA-9009391	7.943983e-01	0.100
Proteasome assembly	R-HSA-9907900	7.954131e-01	0.099
Amine ligand-binding receptors	R-HSA-375280	7.954131e-01	0.099
Unfolded Protein Response (UPR)	R-HSA-381119	7.970917e-01	0.098
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.019487e-01	0.096
Induction of Cell-Cell Fusion	R-HSA-9733458	8.040858e-01	0.095
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.040858e-01	0.095
Differentiation of T cells	R-HSA-9945266	8.040858e-01	0.095
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.040858e-01	0.095
Serotonin and melatonin biosynthesis	R-HSA-209931	8.040858e-01	0.095
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.079854e-01	0.093
Evasion by RSV of host interferon responses	R-HSA-9833109	8.084020e-01	0.092
Defective CFTR causes cystic fibrosis	R-HSA-5678895	8.096259e-01	0.092
Asymmetric localization of PCP proteins	R-HSA-4608870	8.096259e-01	0.092
Reverse Transcription of HIV RNA	R-HSA-162589	8.102168e-01	0.091
Minus-strand DNA synthesis	R-HSA-164516	8.102168e-01	0.091
RSK activation	R-HSA-444257	8.102168e-01	0.091
DAG1 core M2 glycosylations	R-HSA-8932504	8.102168e-01	0.091
EGFR interacts with phospholipase C-gamma	R-HSA-212718	8.102168e-01	0.091
FGFR1b ligand binding and activation	R-HSA-190370	8.102168e-01	0.091
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	8.102168e-01	0.091
Signaling by MRAS-complex mutants	R-HSA-9660537	8.102168e-01	0.091
Activated NTRK2 signals through PI3K	R-HSA-9028335	8.102168e-01	0.091
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	8.102168e-01	0.091
Fructose biosynthesis	R-HSA-5652227	8.102168e-01	0.091
Activation of RAS in B cells	R-HSA-1169092	8.102168e-01	0.091
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	8.102168e-01	0.091
Downregulation of ERBB4 signaling	R-HSA-1253288	8.102168e-01	0.091
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	8.102168e-01	0.091
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	8.102168e-01	0.091
Activated NTRK2 signals through FYN	R-HSA-9032500	8.102168e-01	0.091
Alpha-defensins	R-HSA-1462054	8.102168e-01	0.091
Sodium/Proton exchangers	R-HSA-425986	8.102168e-01	0.091
ER to Golgi Anterograde Transport	R-HSA-199977	8.116349e-01	0.091
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.127020e-01	0.090
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.127020e-01	0.090
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	8.127020e-01	0.090
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	8.127020e-01	0.090
Interleukin-20 family signaling	R-HSA-8854691	8.127020e-01	0.090
rRNA processing	R-HSA-72312	8.170662e-01	0.088
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	8.230540e-01	0.085
Inwardly rectifying K+ channels	R-HSA-1296065	8.242760e-01	0.084
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.248934e-01	0.084
Acetylcholine regulates insulin secretion	R-HSA-399997	8.252441e-01	0.083
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.252441e-01	0.083
Galactose catabolism	R-HSA-70370	8.252441e-01	0.083
Disorders of Developmental Biology	R-HSA-9675151	8.252441e-01	0.083
Passive transport by Aquaporins	R-HSA-432047	8.252441e-01	0.083
tRNA modification in the mitochondrion	R-HSA-6787450	8.252441e-01	0.083
Synthesis of PG	R-HSA-1483148	8.252441e-01	0.083
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.301212e-01	0.081
Interleukin-6 family signaling	R-HSA-6783589	8.301212e-01	0.081
IRE1alpha activates chaperones	R-HSA-381070	8.323344e-01	0.080
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.361846e-01	0.078
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.361846e-01	0.078
Regulation of insulin secretion	R-HSA-422356	8.365749e-01	0.077
MAPK1 (ERK2) activation	R-HSA-112411	8.368375e-01	0.077
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	8.368375e-01	0.077
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	8.368375e-01	0.077
Unwinding of DNA	R-HSA-176974	8.368375e-01	0.077
Gap junction degradation	R-HSA-190873	8.368375e-01	0.077
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	8.368375e-01	0.077
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	8.368375e-01	0.077
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	8.368375e-01	0.077
Regulation of signaling by NODAL	R-HSA-1433617	8.368375e-01	0.077
Defects in biotin (Btn) metabolism	R-HSA-3323169	8.368375e-01	0.077
Cellular response to mitochondrial stress	R-HSA-9840373	8.368375e-01	0.077
GP1b-IX-V activation signalling	R-HSA-430116	8.368375e-01	0.077
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.377556e-01	0.077
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.393588e-01	0.076
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	8.410595e-01	0.075
Signaling by Insulin receptor	R-HSA-74752	8.414820e-01	0.075
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	8.443230e-01	0.073
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.443230e-01	0.073
Regulation of FZD by ubiquitination	R-HSA-4641263	8.443230e-01	0.073
Regulation of NPAS4 gene expression	R-HSA-9768759	8.443230e-01	0.073
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.461300e-01	0.073
PI-3K cascade:FGFR2	R-HSA-5654695	8.461300e-01	0.073
Interferon gamma signaling	R-HSA-877300	8.462112e-01	0.073
Adaptive Immune System	R-HSA-1280218	8.489560e-01	0.071
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.489599e-01	0.071
Hh mutants are degraded by ERAD	R-HSA-5362768	8.489599e-01	0.071
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.509336e-01	0.070
Glucagon signaling in metabolic regulation	R-HSA-163359	8.527575e-01	0.069
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.527575e-01	0.069
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.527575e-01	0.069
DNA Damage Bypass	R-HSA-73893	8.588505e-01	0.066
Binding and entry of HIV virion	R-HSA-173107	8.597255e-01	0.066
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	8.597255e-01	0.066
DNA replication initiation	R-HSA-68952	8.597255e-01	0.066
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	8.597255e-01	0.066
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.597255e-01	0.066
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	8.597255e-01	0.066
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	8.597255e-01	0.066
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	8.597255e-01	0.066
Interleukin-27 signaling	R-HSA-9020956	8.597255e-01	0.066
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.597255e-01	0.066
Sperm Motility And Taxes	R-HSA-1300642	8.597255e-01	0.066
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.597255e-01	0.066
Serotonin receptors	R-HSA-390666	8.597255e-01	0.066
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.608110e-01	0.065
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.608110e-01	0.065
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.608975e-01	0.065
HIV Transcription Initiation	R-HSA-167161	8.608975e-01	0.065
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.608975e-01	0.065
Intra-Golgi traffic	R-HSA-6811438	8.608975e-01	0.065
GAB1 signalosome	R-HSA-180292	8.614895e-01	0.065
Tie2 Signaling	R-HSA-210993	8.614895e-01	0.065
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	8.614895e-01	0.065
Amyloid fiber formation	R-HSA-977225	8.621159e-01	0.064
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.654648e-01	0.063
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	8.654648e-01	0.063
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.664056e-01	0.062
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.671890e-01	0.062
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.683371e-01	0.061
Signaling by NOTCH4	R-HSA-9013694	8.692165e-01	0.061
Hemostasis	R-HSA-109582	8.703289e-01	0.060
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	8.720333e-01	0.059
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	8.742469e-01	0.058
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	8.769047e-01	0.057
Pyrimidine biosynthesis	R-HSA-500753	8.769047e-01	0.057
Crosslinking of collagen fibrils	R-HSA-2243919	8.769047e-01	0.057
Other interleukin signaling	R-HSA-449836	8.769047e-01	0.057
Downstream signaling of activated FGFR1	R-HSA-5654687	8.772190e-01	0.057
Downstream signaling of activated FGFR2	R-HSA-5654696	8.772190e-01	0.057
Triglyceride metabolism	R-HSA-8979227	8.776925e-01	0.057
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.792270e-01	0.056
The phototransduction cascade	R-HSA-2514856	8.792270e-01	0.056
Hedgehog ligand biogenesis	R-HSA-5358346	8.792270e-01	0.056
DAG1 core M3 glycosylations	R-HSA-8932505	8.794039e-01	0.056
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.794039e-01	0.056
FGFR2b ligand binding and activation	R-HSA-190377	8.794039e-01	0.056
vRNA Synthesis	R-HSA-192814	8.794039e-01	0.056
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.794039e-01	0.056
vRNP Assembly	R-HSA-192905	8.794039e-01	0.056
Activated NTRK3 signals through RAS	R-HSA-9034864	8.794039e-01	0.056
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	8.794039e-01	0.056
Bicarbonate transporters	R-HSA-425381	8.794039e-01	0.056
Transport of RCbl within the body	R-HSA-9758890	8.794039e-01	0.056
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.794039e-01	0.056
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.794039e-01	0.056
PECAM1 interactions	R-HSA-210990	8.794039e-01	0.056
Suppression of apoptosis	R-HSA-9635465	8.794039e-01	0.056
RNA Polymerase II Promoter Escape	R-HSA-73776	8.824040e-01	0.054
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	8.824040e-01	0.054
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	8.833972e-01	0.054
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.865200e-01	0.052
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.865200e-01	0.052
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.880724e-01	0.052
RNA Polymerase III Transcription	R-HSA-74158	8.880724e-01	0.052
FGFR2 mutant receptor activation	R-HSA-1839126	8.880724e-01	0.052
GPVI-mediated activation cascade	R-HSA-114604	8.880724e-01	0.052
Formation of ATP by chemiosmotic coupling	R-HSA-163210	8.907220e-01	0.050
VxPx cargo-targeting to cilium	R-HSA-5620916	8.907220e-01	0.050
Acyl chain remodelling of PI	R-HSA-1482922	8.907220e-01	0.050
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.907220e-01	0.050
Pregnenolone biosynthesis	R-HSA-196108	8.907220e-01	0.050
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.907220e-01	0.050
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.923411e-01	0.049
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.959275e-01	0.048
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.963227e-01	0.048
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.963227e-01	0.048
Plasmalogen biosynthesis	R-HSA-75896	8.963227e-01	0.048
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.963227e-01	0.048
FMO oxidises nucleophiles	R-HSA-217271	8.963227e-01	0.048
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	8.963227e-01	0.048
Activated NTRK2 signals through RAS	R-HSA-9026519	8.963227e-01	0.048
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.963227e-01	0.048
Integration of provirus	R-HSA-162592	8.963227e-01	0.048
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.977109e-01	0.047
TRAF6 mediated IRF7 activation	R-HSA-933541	8.980774e-01	0.047
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.010000e-01	0.045
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.010000e-01	0.045
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.010000e-01	0.045
SARS-CoV-1-host interactions	R-HSA-9692914	9.023922e-01	0.045
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.030862e-01	0.044
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.030862e-01	0.044
Phenylalanine metabolism	R-HSA-8964208	9.030862e-01	0.044
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.030862e-01	0.044
Translation initiation complex formation	R-HSA-72649	9.051108e-01	0.043
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.072855e-01	0.042
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.078976e-01	0.042
DAP12 signaling	R-HSA-2424491	9.078976e-01	0.042
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	9.078976e-01	0.042
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.078976e-01	0.042
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.078976e-01	0.042
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.092999e-01	0.041
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.092999e-01	0.041
VLDLR internalisation and degradation	R-HSA-8866427	9.108688e-01	0.041
Serotonin clearance from the synaptic cleft	R-HSA-380615	9.108688e-01	0.041
Interleukin-35 Signalling	R-HSA-8984722	9.108688e-01	0.041
Proline catabolism	R-HSA-70688	9.108688e-01	0.041
Signaling by LTK	R-HSA-9842663	9.108688e-01	0.041
Trafficking and processing of endosomal TLR	R-HSA-1679131	9.108688e-01	0.041
Diseases associated with surfactant metabolism	R-HSA-5687613	9.108688e-01	0.041
RUNX3 regulates p14-ARF	R-HSA-8951936	9.108688e-01	0.041
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	9.108688e-01	0.041
SHC-related events triggered by IGF1R	R-HSA-2428933	9.108688e-01	0.041
Disorders of Nervous System Development	R-HSA-9697154	9.108688e-01	0.041
Pervasive developmental disorders	R-HSA-9005895	9.108688e-01	0.041
G alpha (z) signalling events	R-HSA-418597	9.126045e-01	0.040
Signaling by NOTCH3	R-HSA-9012852	9.126045e-01	0.040
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.141330e-01	0.039
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.141330e-01	0.039
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.141330e-01	0.039
Assembly Of The HIV Virion	R-HSA-175474	9.141330e-01	0.039
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.141330e-01	0.039
Mitochondrial calcium ion transport	R-HSA-8949215	9.141330e-01	0.039
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.157474e-01	0.038
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.157474e-01	0.038
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.169836e-01	0.038
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.171556e-01	0.038
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.171556e-01	0.038
Ribosomal scanning and start codon recognition	R-HSA-72702	9.195785e-01	0.036
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.195785e-01	0.036
Adenylate cyclase activating pathway	R-HSA-170660	9.233747e-01	0.035
FGFR2c ligand binding and activation	R-HSA-190375	9.233747e-01	0.035
FGFR1c ligand binding and activation	R-HSA-190373	9.233747e-01	0.035
Membrane binding and targetting of GAG proteins	R-HSA-174490	9.233747e-01	0.035
FGFR4 ligand binding and activation	R-HSA-190322	9.233747e-01	0.035
Signaling by activated point mutants of FGFR3	R-HSA-1839130	9.233747e-01	0.035
Mtb iron assimilation by chelation	R-HSA-1222449	9.233747e-01	0.035
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	9.233747e-01	0.035
PI5P Regulates TP53 Acetylation	R-HSA-6811555	9.233747e-01	0.035
FGFR3 mutant receptor activation	R-HSA-2033514	9.233747e-01	0.035
rRNA modification in the mitochondrion	R-HSA-6793080	9.233747e-01	0.035
Replication of the SARS-CoV-1 genome	R-HSA-9682706	9.233747e-01	0.035
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.239887e-01	0.034
Fructose metabolism	R-HSA-5652084	9.239887e-01	0.034
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.239887e-01	0.034
LDL clearance	R-HSA-8964038	9.239887e-01	0.034
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.239887e-01	0.034
Neurotoxicity of clostridium toxins	R-HSA-168799	9.239887e-01	0.034
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.302484e-01	0.031
Cytoprotection by HMOX1	R-HSA-9707564	9.302484e-01	0.031
Protein ubiquitination	R-HSA-8852135	9.319051e-01	0.031
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.319051e-01	0.031
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	9.320787e-01	0.031
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.320787e-01	0.031
Regulation of PTEN mRNA translation	R-HSA-8943723	9.327699e-01	0.030
Carnitine shuttle	R-HSA-200425	9.327699e-01	0.030
Phospholipid metabolism	R-HSA-1483257	9.340548e-01	0.030
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.341266e-01	0.030
Retrograde neurotrophin signalling	R-HSA-177504	9.341266e-01	0.030
FGFR3c ligand binding and activation	R-HSA-190372	9.341266e-01	0.030
Transport of fatty acids	R-HSA-804914	9.341266e-01	0.030
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	9.341266e-01	0.030
Hydrolysis of LPC	R-HSA-1483115	9.341266e-01	0.030
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	9.341266e-01	0.030
Malate-aspartate shuttle	R-HSA-9856872	9.341266e-01	0.030
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.341266e-01	0.030
HDL assembly	R-HSA-8963896	9.341266e-01	0.030
Signal regulatory protein family interactions	R-HSA-391160	9.341266e-01	0.030
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	9.341266e-01	0.030
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.371382e-01	0.028
Acyl chain remodelling of PC	R-HSA-1482788	9.400584e-01	0.027
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.405840e-01	0.027
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.405840e-01	0.027
Translation of Structural Proteins	R-HSA-9694635	9.416867e-01	0.026
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.428035e-01	0.026
GABA receptor activation	R-HSA-977443	9.428275e-01	0.026
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.433703e-01	0.025
Activation of BAD and translocation to mitochondria	R-HSA-111447	9.433703e-01	0.025
G beta:gamma signalling through BTK	R-HSA-8964315	9.433703e-01	0.025
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.433703e-01	0.025
Translesion synthesis by REV1	R-HSA-110312	9.433703e-01	0.025
Signaling by Activin	R-HSA-1502540	9.433703e-01	0.025
FGFR3 ligand binding and activation	R-HSA-190239	9.433703e-01	0.025
Events associated with phagocytolytic activity of PMN cells	R-HSA-8941413	9.433703e-01	0.025
Protein repair	R-HSA-5676934	9.433703e-01	0.025
Lysosphingolipid and LPA receptors	R-HSA-419408	9.433703e-01	0.025
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	9.433703e-01	0.025
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	9.433703e-01	0.025
Signaling by NOTCH2	R-HSA-1980145	9.462842e-01	0.024
eNOS activation	R-HSA-203615	9.462842e-01	0.024
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.462842e-01	0.024
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.462842e-01	0.024
Activation of G protein gated Potassium channels	R-HSA-1296041	9.475296e-01	0.023
G protein gated Potassium channels	R-HSA-1296059	9.475296e-01	0.023
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.475296e-01	0.023
Acyl chain remodelling of PS	R-HSA-1482801	9.475296e-01	0.023
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.475296e-01	0.023
Aquaporin-mediated transport	R-HSA-445717	9.476093e-01	0.023
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.481803e-01	0.023
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	R-HSA-2142816	9.513173e-01	0.022
Translesion synthesis by POLI	R-HSA-5656121	9.513173e-01	0.022
Class I peroxisomal membrane protein import	R-HSA-9603798	9.513173e-01	0.022
Attachment and Entry	R-HSA-9678110	9.513173e-01	0.022
Killing mechanisms	R-HSA-9664420	9.513173e-01	0.022
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	9.513173e-01	0.022
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.513173e-01	0.022
Fructose catabolism	R-HSA-70350	9.513173e-01	0.022
Carnitine synthesis	R-HSA-71262	9.513173e-01	0.022
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	9.513173e-01	0.022
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	9.513173e-01	0.022
Atorvastatin ADME	R-HSA-9754706	9.513173e-01	0.022
Interferon alpha/beta signaling	R-HSA-909733	9.515175e-01	0.022
Acyl chain remodelling of PE	R-HSA-1482839	9.519039e-01	0.021
NCAM signaling for neurite out-growth	R-HSA-375165	9.520287e-01	0.021
Signaling by PDGF	R-HSA-186797	9.520287e-01	0.021
Amino acids regulate mTORC1	R-HSA-9639288	9.520975e-01	0.021
Surfactant metabolism	R-HSA-5683826	9.534728e-01	0.021
MET activates PTK2 signaling	R-HSA-8874081	9.536964e-01	0.021
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.536964e-01	0.021
Sphingolipid catabolism	R-HSA-9845614	9.536964e-01	0.021
Urea cycle	R-HSA-70635	9.536964e-01	0.021
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.539230e-01	0.020
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.541238e-01	0.020
SARS-CoV-1 Infection	R-HSA-9678108	9.550954e-01	0.020
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.564193e-01	0.019
Lysosome Vesicle Biogenesis	R-HSA-432720	9.569706e-01	0.019
Glycosphingolipid transport	R-HSA-9845576	9.569706e-01	0.019
G beta:gamma signalling through CDC42	R-HSA-8964616	9.581496e-01	0.019
Translesion synthesis by POLK	R-HSA-5655862	9.581496e-01	0.019
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.581496e-01	0.019
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.581496e-01	0.019
Formation of xylulose-5-phosphate	R-HSA-5661270	9.581496e-01	0.019
Coenzyme A biosynthesis	R-HSA-196783	9.581496e-01	0.019
ER-Phagosome pathway	R-HSA-1236974	9.589348e-01	0.018
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.591662e-01	0.018
Signaling by BMP	R-HSA-201451	9.591662e-01	0.018
Insulin processing	R-HSA-264876	9.591662e-01	0.018
tRNA processing	R-HSA-72306	9.619089e-01	0.017
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.640132e-01	0.016
Insulin receptor recycling	R-HSA-77387	9.640132e-01	0.016
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.640233e-01	0.016
Catecholamine biosynthesis	R-HSA-209905	9.640233e-01	0.016
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.640233e-01	0.016
Elastic fibre formation	R-HSA-1566948	9.656383e-01	0.015
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.665307e-01	0.015
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.683043e-01	0.014
G beta:gamma signalling through PLC beta	R-HSA-418217	9.690729e-01	0.014
Activated point mutants of FGFR2	R-HSA-2033519	9.690729e-01	0.014
FGFR1 ligand binding and activation	R-HSA-190242	9.690729e-01	0.014
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	R-HSA-2142670	9.690729e-01	0.014
RNA Polymerase III Transcription Termination	R-HSA-73980	9.690729e-01	0.014
Presynaptic function of Kainate receptors	R-HSA-500657	9.690729e-01	0.014
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.690729e-01	0.014
Biosynthesis of DHA-derived sulfido conjugates	R-HSA-9026395	9.690729e-01	0.014
Vitamin D (calciferol) metabolism	R-HSA-196791	9.690729e-01	0.014
GPER1 signaling	R-HSA-9634597	9.691977e-01	0.014
RAS processing	R-HSA-9648002	9.693273e-01	0.014
Pentose phosphate pathway	R-HSA-71336	9.693273e-01	0.014
SLC transporter disorders	R-HSA-5619102	9.699751e-01	0.013
ABC-family proteins mediated transport	R-HSA-382556	9.709042e-01	0.013
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.726394e-01	0.012
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.731412e-01	0.012
Regulation of signaling by CBL	R-HSA-912631	9.734140e-01	0.012
Translesion Synthesis by POLH	R-HSA-110320	9.734140e-01	0.012
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.734140e-01	0.012
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	9.734140e-01	0.012
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.734140e-01	0.012
Protein localization	R-HSA-9609507	9.738551e-01	0.012
ABC transporter disorders	R-HSA-5619084	9.742207e-01	0.011
Developmental Cell Lineages	R-HSA-9734767	9.752312e-01	0.011
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.754551e-01	0.011
Maturation of spike protein	R-HSA-9694548	9.756103e-01	0.011
RAB geranylgeranylation	R-HSA-8873719	9.756710e-01	0.011
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.756710e-01	0.011
Glutathione conjugation	R-HSA-156590	9.756710e-01	0.011
Metabolism of polyamines	R-HSA-351202	9.756710e-01	0.011
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.771460e-01	0.010
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.771460e-01	0.010
Glycogen synthesis	R-HSA-3322077	9.771460e-01	0.010
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.782728e-01	0.010
Translation of Structural Proteins	R-HSA-9683701	9.782728e-01	0.010
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.798417e-01	0.009
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.803543e-01	0.009
FGFR2 ligand binding and activation	R-HSA-190241	9.803543e-01	0.009
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.803543e-01	0.009
Early Phase of HIV Life Cycle	R-HSA-162594	9.803543e-01	0.009
G-protein activation	R-HSA-202040	9.803543e-01	0.009
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.803543e-01	0.009
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.803543e-01	0.009
Activation of GABAB receptors	R-HSA-991365	9.806567e-01	0.008
GABA B receptor activation	R-HSA-977444	9.806567e-01	0.008
Immune System	R-HSA-168256	9.808635e-01	0.008
Nucleotide biosynthesis	R-HSA-8956320	9.818989e-01	0.008
Response of Mtb to phagocytosis	R-HSA-9637690	9.827896e-01	0.008
Attachment and Entry	R-HSA-9694614	9.831123e-01	0.007
Ribavirin ADME	R-HSA-9755088	9.831123e-01	0.007
Molybdenum cofactor biosynthesis	R-HSA-947581	9.831123e-01	0.007
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	9.831123e-01	0.007
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.831123e-01	0.007
Serine metabolism	R-HSA-977347	9.831123e-01	0.007
Glutathione synthesis and recycling	R-HSA-174403	9.831123e-01	0.007
DAP12 interactions	R-HSA-2172127	9.846963e-01	0.007
Signal amplification	R-HSA-392518	9.853725e-01	0.006
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.853725e-01	0.006
Hyaluronan metabolism	R-HSA-2142845	9.853725e-01	0.006
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.854833e-01	0.006
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.854833e-01	0.006
Cellular hexose transport	R-HSA-189200	9.854833e-01	0.006
Citric acid cycle (TCA cycle)	R-HSA-71403	9.856880e-01	0.006
Antigen processing-Cross presentation	R-HSA-1236975	9.858797e-01	0.006
Metabolism of amine-derived hormones	R-HSA-209776	9.869426e-01	0.006
PPARA activates gene expression	R-HSA-1989781	9.870147e-01	0.006
Free fatty acids regulate insulin secretion	R-HSA-400451	9.875216e-01	0.005
Biosynthesis of maresins	R-HSA-9018682	9.875216e-01	0.005
Formation of the ureteric bud	R-HSA-9830674	9.875216e-01	0.005
ABC transporters in lipid homeostasis	R-HSA-1369062	9.875216e-01	0.005
Selenoamino acid metabolism	R-HSA-2408522	9.875321e-01	0.005
Viral Infection Pathways	R-HSA-9824446	9.875811e-01	0.005
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.887410e-01	0.005
CYP2E1 reactions	R-HSA-211999	9.892737e-01	0.005
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.892737e-01	0.005
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.892737e-01	0.005
Thromboxane signalling through TP receptor	R-HSA-428930	9.892737e-01	0.005
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.892737e-01	0.005
Mitochondrial RNA degradation	R-HSA-9836573	9.892737e-01	0.005
TNFs bind their physiological receptors	R-HSA-5669034	9.892737e-01	0.005
Plasma lipoprotein assembly	R-HSA-8963898	9.892737e-01	0.005
Synthesis of PC	R-HSA-1483191	9.892759e-01	0.005
SARS-CoV Infections	R-HSA-9679506	9.896655e-01	0.005
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.901261e-01	0.004
SLC-mediated transport of organic cations	R-HSA-549127	9.901261e-01	0.004
NCAM1 interactions	R-HSA-419037	9.901261e-01	0.004
G alpha (q) signalling events	R-HSA-416476	9.901886e-01	0.004
Peroxisomal protein import	R-HSA-9033241	9.906297e-01	0.004
Alpha-oxidation of phytanate	R-HSA-389599	9.907799e-01	0.004
Hyaluronan degradation	R-HSA-2160916	9.907799e-01	0.004
Fertilization	R-HSA-1187000	9.907799e-01	0.004
Laminin interactions	R-HSA-3000157	9.907799e-01	0.004
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.907799e-01	0.004
RSV-host interactions	R-HSA-9833110	9.908374e-01	0.004
Transport to the Golgi and subsequent modification	R-HSA-948021	9.914715e-01	0.004
FCERI mediated NF-kB activation	R-HSA-2871837	9.917592e-01	0.004
Abacavir ADME	R-HSA-2161522	9.920747e-01	0.003
Suppression of phagosomal maturation	R-HSA-9637687	9.920747e-01	0.003
Neurotransmitter release cycle	R-HSA-112310	9.922677e-01	0.003
Plasma lipoprotein clearance	R-HSA-8964043	9.924173e-01	0.003
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.929249e-01	0.003
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.931877e-01	0.003
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.931877e-01	0.003
Triglyceride biosynthesis	R-HSA-75109	9.931877e-01	0.003
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.931877e-01	0.003
Maturation of hRSV A proteins	R-HSA-9828806	9.931877e-01	0.003
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.933588e-01	0.003
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.933588e-01	0.003
Glycogen metabolism	R-HSA-8982491	9.933588e-01	0.003
Disorders of transmembrane transporters	R-HSA-5619115	9.937176e-01	0.003
Parasite infection	R-HSA-9664407	9.938924e-01	0.003
Leishmania phagocytosis	R-HSA-9664417	9.938924e-01	0.003
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.938924e-01	0.003
Prednisone ADME	R-HSA-9757110	9.941445e-01	0.003
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.941855e-01	0.003
Parasitic Infection Pathways	R-HSA-9824443	9.942311e-01	0.003
Leishmania infection	R-HSA-9658195	9.942311e-01	0.003
ROS and RNS production in phagocytes	R-HSA-1222556	9.942853e-01	0.002
Xenobiotics	R-HSA-211981	9.946665e-01	0.002
Potential therapeutics for SARS	R-HSA-9679191	9.948436e-01	0.002
Thyroxine biosynthesis	R-HSA-209968	9.949669e-01	0.002
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.949669e-01	0.002
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.949669e-01	0.002
Glucagon-type ligand receptors	R-HSA-420092	9.949669e-01	0.002
Collagen formation	R-HSA-1474290	9.952488e-01	0.002
Cytosolic tRNA aminoacylation	R-HSA-379716	9.955475e-01	0.002
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.956739e-01	0.002
Neurotransmitter clearance	R-HSA-112311	9.956739e-01	0.002
Neddylation	R-HSA-8951664	9.961292e-01	0.002
Metabolism of steroid hormones	R-HSA-196071	9.962185e-01	0.002
Molecules associated with elastic fibres	R-HSA-2129379	9.962816e-01	0.002
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.962816e-01	0.002
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.966773e-01	0.001
DAG1 glycosylations	R-HSA-8931838	9.968039e-01	0.001
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.972529e-01	0.001
COPII-mediated vesicle transport	R-HSA-204005	9.973295e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.973295e-01	0.001
Glutamate and glutamine metabolism	R-HSA-8964539	9.976389e-01	0.001
Heme degradation	R-HSA-189483	9.976389e-01	0.001
Calnexin/calreticulin cycle	R-HSA-901042	9.979706e-01	0.001
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.979706e-01	0.001
Endogenous sterols	R-HSA-211976	9.980705e-01	0.001
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.981505e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.982034e-01	0.001
Transferrin endocytosis and recycling	R-HSA-917977	9.982558e-01	0.001
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.982558e-01	0.001
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.982558e-01	0.001
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.983302e-01	0.001
Azathioprine ADME	R-HSA-9748787	9.984874e-01	0.001
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.984874e-01	0.001
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.987116e-01	0.001
Cholesterol biosynthesis	R-HSA-191273	9.989622e-01	0.000
Post-translational protein phosphorylation	R-HSA-8957275	9.990327e-01	0.000
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.990483e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.990957e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.991329e-01	0.000
rRNA processing in the mitochondrion	R-HSA-8868766	9.991820e-01	0.000
Paracetamol ADME	R-HSA-9753281	9.992361e-01	0.000
Aflatoxin activation and detoxification	R-HSA-5423646	9.992970e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.993920e-01	0.000
Scavenging by Class A Receptors	R-HSA-3000480	9.993958e-01	0.000
Synthesis of PA	R-HSA-1483166	9.994197e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.994577e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.994577e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.994577e-01	0.000
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.994808e-01	0.000
Defensins	R-HSA-1461973	9.995538e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.995591e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.995666e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.996163e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.996163e-01	0.000
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.996165e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.996510e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.996568e-01	0.000
Degradation of cysteine and homocysteine	R-HSA-1614558	9.996704e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.996913e-01	0.000
Regulation of pyruvate metabolism	R-HSA-9861718	9.997168e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.997285e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.997411e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.997616e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.997726e-01	0.000
Innate Immune System	R-HSA-168249	9.997788e-01	0.000
Integrin cell surface interactions	R-HSA-216083	9.997807e-01	0.000
Plasma lipoprotein remodeling	R-HSA-8963899	9.997908e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.998075e-01	0.000
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.998202e-01	0.000
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.998202e-01	0.000
Chemokine receptors bind chemokines	R-HSA-380108	9.998202e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.998498e-01	0.000
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.998529e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998548e-01	0.000
Translation	R-HSA-72766	9.998569e-01	0.000
Complex IV assembly	R-HSA-9864848	9.998672e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.998737e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999077e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.999170e-01	0.000
Purine catabolism	R-HSA-74259	9.999278e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999351e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999373e-01	0.000
Digestion	R-HSA-8935690	9.999378e-01	0.000
Iron uptake and transport	R-HSA-917937	9.999526e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999566e-01	0.000
Sialic acid metabolism	R-HSA-4085001	9.999605e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.999643e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.999690e-01	0.000
Collagen degradation	R-HSA-1442490	9.999709e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999749e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999755e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999773e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.999785e-01	0.000
Digestion and absorption	R-HSA-8963743	9.999785e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999797e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999797e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999809e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.999815e-01	0.000
Glycosphingolipid biosynthesis	R-HSA-9840309	9.999815e-01	0.000
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.999841e-01	0.000
SLC-mediated transport of amino acids	R-HSA-9958863	9.999883e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999897e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.999899e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999913e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.999926e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.999936e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999951e-01	0.000
Aspirin ADME	R-HSA-9749641	9.999953e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999953e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999961e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999976e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.999977e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999978e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999991e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999991e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999994e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999996e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999996e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999998e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999998e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999998e-01	0.000
Disease	R-HSA-1643685	9.999998e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999999e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.999999e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999999e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999999e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999999e-01	0.000
Infectious disease	R-HSA-5663205	9.999999e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Initial triggering of complement	R-HSA-166663	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000e+00	0.000
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000
Post-translational protein modification	R-HSA-597592	1.000000e+00	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
HSF1-dependent transactivation	R-HSA-3371571	2.153833e-14	13.667
Attenuation phase	R-HSA-3371568	9.781065e-14	13.010
Cellular response to heat stress	R-HSA-3371556	9.106049e-13	12.041
HSF1 activation	R-HSA-3371511	1.206834e-10	9.918
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.323408e-10	9.364
Cell Cycle, Mitotic	R-HSA-69278	9.591944e-10	9.018
Cell Cycle	R-HSA-1640170	1.366951e-09	8.864
Aggrephagy	R-HSA-9646399	3.339031e-09	8.476
M Phase	R-HSA-68886	8.234323e-09	8.084
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.292785e-08	7.482
Apoptotic execution phase	R-HSA-75153	3.749664e-08	7.426
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	4.437373e-08	7.353
Kinesins	R-HSA-983189	1.260843e-07	6.899
Cellular responses to stress	R-HSA-2262752	1.223418e-07	6.912
Separation of Sister Chromatids	R-HSA-2467813	2.008163e-07	6.697
Cellular responses to stimuli	R-HSA-8953897	1.948756e-07	6.710
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.513106e-07	6.600
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	2.926719e-07	6.534
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.392192e-07	6.470
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.615193e-07	6.442
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.451400e-07	6.352
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	4.142914e-07	6.383
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	4.393598e-07	6.357
Mitotic Anaphase	R-HSA-68882	5.219367e-07	6.282
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.880658e-07	6.231
Signal Transduction	R-HSA-162582	5.752417e-07	6.240
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.977732e-07	6.156
Transport of connexons to the plasma membrane	R-HSA-190872	6.758626e-07	6.170
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	7.636731e-07	6.117
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	8.795580e-07	6.056
Apoptosis	R-HSA-109581	9.442535e-07	6.025
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.527429e-06	5.816
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.674364e-06	5.776
G2/M Transition	R-HSA-69275	1.771091e-06	5.752
Death Receptor Signaling	R-HSA-73887	1.910599e-06	5.719
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.963659e-06	5.707
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.037486e-06	5.691
Mitotic G2-G2/M phases	R-HSA-453274	2.258986e-06	5.646
PKR-mediated signaling	R-HSA-9833482	3.318550e-06	5.479
Recycling pathway of L1	R-HSA-437239	3.348409e-06	5.475
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.885810e-06	5.411
Signaling by ALK in cancer	R-HSA-9700206	3.885810e-06	5.411
Mitotic Prometaphase	R-HSA-68877	4.077662e-06	5.390
Interleukin-12 signaling	R-HSA-9020591	4.701562e-06	5.328
Post NMDA receptor activation events	R-HSA-438064	4.921838e-06	5.308
p75 NTR receptor-mediated signalling	R-HSA-193704	6.750886e-06	5.171
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	8.092904e-06	5.092
Programmed Cell Death	R-HSA-5357801	7.955782e-06	5.099
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	9.108115e-06	5.041
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	9.993766e-06	5.000
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.091464e-05	4.962
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.135733e-05	4.945
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.265997e-05	4.898
Interleukin-12 family signaling	R-HSA-447115	1.414098e-05	4.850
Selective autophagy	R-HSA-9663891	1.673526e-05	4.776
Axon guidance	R-HSA-422475	1.684925e-05	4.773
Nervous system development	R-HSA-9675108	2.180454e-05	4.661
Oncogenic MAPK signaling	R-HSA-6802957	2.394403e-05	4.621
Signaling downstream of RAS mutants	R-HSA-9649948	3.395485e-05	4.469
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	3.395485e-05	4.469
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	3.395485e-05	4.469
Signaling by RAS mutants	R-HSA-6802949	3.395485e-05	4.469
Signaling by RAF1 mutants	R-HSA-9656223	3.736031e-05	4.428
Protein folding	R-HSA-391251	3.738329e-05	4.427
Chaperonin-mediated protein folding	R-HSA-390466	3.911169e-05	4.408
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	4.160611e-05	4.381
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.582140e-05	4.339
L1CAM interactions	R-HSA-373760	4.964985e-05	4.304
Striated Muscle Contraction	R-HSA-390522	5.429709e-05	4.265
HDACs deacetylate histones	R-HSA-3214815	6.895018e-05	4.161
Metalloprotease DUBs	R-HSA-5689901	9.612337e-05	4.017
Cell-extracellular matrix interactions	R-HSA-446353	1.293940e-04	3.888
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.371700e-04	3.863
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.407434e-04	3.852
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.449539e-04	3.839
Autophagy	R-HSA-9612973	1.478093e-04	3.830
Golgi-to-ER retrograde transport	R-HSA-8856688	1.926227e-04	3.715
Gap junction trafficking	R-HSA-190828	2.421702e-04	3.616
Gap junction assembly	R-HSA-190861	2.546370e-04	3.594
Macroautophagy	R-HSA-1632852	2.638298e-04	3.579
Diseases of programmed cell death	R-HSA-9645723	3.048336e-04	3.516
Cell-Cell communication	R-HSA-1500931	3.210595e-04	3.493
Josephin domain DUBs	R-HSA-5689877	3.354416e-04	3.474
Cargo trafficking to the periciliary membrane	R-HSA-5620920	3.797151e-04	3.421
MAP2K and MAPK activation	R-HSA-5674135	4.215476e-04	3.375
Cellular Senescence	R-HSA-2559583	4.011305e-04	3.397
Mitotic Prophase	R-HSA-68875	4.277748e-04	3.369
Meiosis	R-HSA-1500620	4.361640e-04	3.360
Cohesin Loading onto Chromatin	R-HSA-2470946	5.058881e-04	3.296
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.922419e-04	3.308
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.924137e-04	3.308
Chaperone Mediated Autophagy	R-HSA-9613829	5.138464e-04	3.289
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.109290e-04	3.292
Regulation of PTEN localization	R-HSA-8948747	5.058881e-04	3.296
Membrane Trafficking	R-HSA-199991	4.662325e-04	3.331
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	4.924137e-04	3.308
Intraflagellar transport	R-HSA-5620924	5.173889e-04	3.286
Regulation of MECP2 expression and activity	R-HSA-9022692	5.613623e-04	3.251
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	6.026125e-04	3.220
Gap junction trafficking and regulation	R-HSA-157858	6.178834e-04	3.209
TNF signaling	R-HSA-75893	7.098069e-04	3.149
Hedgehog 'off' state	R-HSA-5610787	7.613606e-04	3.118
Chromatin organization	R-HSA-4839726	7.789652e-04	3.108
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	8.168529e-04	3.088
Regulation of CDH1 Expression and Function	R-HSA-9764265	8.168529e-04	3.088
Chromatin modifying enzymes	R-HSA-3247509	8.251794e-04	3.083
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	8.262395e-04	3.083
Regulation of CDH1 Gene Transcription	R-HSA-9764560	8.478034e-04	3.072
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	8.903433e-04	3.050
Regulation of endogenous retroelements	R-HSA-9842860	9.596130e-04	3.018
COPI-mediated anterograde transport	R-HSA-6807878	1.077575e-03	2.968
G alpha (12/13) signalling events	R-HSA-416482	1.021909e-03	2.991
Cell junction organization	R-HSA-446728	1.101367e-03	2.958
Meiotic synapsis	R-HSA-1221632	1.202566e-03	2.920
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.281842e-03	2.892
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	1.284117e-03	2.891
HCMV Early Events	R-HSA-9609690	1.514673e-03	2.820
Cell Cycle Checkpoints	R-HSA-69620	1.456782e-03	2.837
Ovarian tumor domain proteases	R-HSA-5689896	1.548179e-03	2.810
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.699411e-03	2.770
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.750519e-03	2.757
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.755131e-03	2.756
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.844890e-03	2.734
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.914332e-03	2.718
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.165038e-03	2.665
G2/M Checkpoints	R-HSA-69481	2.027549e-03	2.693
Regulation of CDH1 Function	R-HSA-9764561	2.195944e-03	2.658
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.224379e-03	2.653
Late endosomal microautophagy	R-HSA-9615710	2.659351e-03	2.575
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.745778e-03	2.561
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.702987e-03	2.568
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	2.754480e-03	2.560
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.721345e-03	2.565
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.904503e-03	2.537
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.911557e-03	2.536
p75NTR signals via NF-kB	R-HSA-193639	2.911557e-03	2.536
Regulation of TNFR1 signaling	R-HSA-5357905	2.946646e-03	2.531
Breakdown of the nuclear lamina	R-HSA-352238	3.307982e-03	2.480
Regulation of NF-kappa B signaling	R-HSA-9758274	3.840744e-03	2.416
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	3.430189e-03	2.465
Neurodegenerative Diseases	R-HSA-8863678	3.106820e-03	2.508
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.106820e-03	2.508
Deubiquitination	R-HSA-5688426	3.421779e-03	2.466
Epigenetic regulation of gene expression	R-HSA-212165	3.720184e-03	2.429
Signaling by ERBB2	R-HSA-1227986	3.323810e-03	2.478
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	3.833696e-03	2.416
Negative regulation of MAPK pathway	R-HSA-5675221	3.659862e-03	2.437
Regulation of PTEN gene transcription	R-HSA-8943724	3.323810e-03	2.478
MAP kinase activation	R-HSA-450294	3.791556e-03	2.421
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	3.138808e-03	2.503
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.611181e-03	2.442
PTEN Regulation	R-HSA-6807070	3.575316e-03	2.447
Signaling by Hedgehog	R-HSA-5358351	3.287720e-03	2.483
Nephrin family interactions	R-HSA-373753	3.532812e-03	2.452
NF-kB is activated and signals survival	R-HSA-209560	3.844222e-03	2.415
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	3.844222e-03	2.415
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	3.844222e-03	2.415
ISG15 antiviral mechanism	R-HSA-1169408	3.881735e-03	2.411
Budding and maturation of HIV virion	R-HSA-162588	3.911524e-03	2.408
ER to Golgi Anterograde Transport	R-HSA-199977	3.968097e-03	2.401
HCMV Infection	R-HSA-9609646	4.170266e-03	2.380
Signaling by NTRKs	R-HSA-166520	4.295823e-03	2.367
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.691861e-03	2.329
NRAGE signals death through JNK	R-HSA-193648	4.786737e-03	2.320
Myoclonic epilepsy of Lafora	R-HSA-3785653	4.788068e-03	2.320
Downregulation of ERBB4 signaling	R-HSA-1253288	4.788068e-03	2.320
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	4.788068e-03	2.320
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.788068e-03	2.320
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	4.801091e-03	2.319
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	4.914836e-03	2.308
MHC class II antigen presentation	R-HSA-2132295	5.003179e-03	2.301
FLT3 signaling by CBL mutants	R-HSA-9706377	5.175920e-03	2.286
p75NTR recruits signalling complexes	R-HSA-209543	5.224524e-03	2.282
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	5.294199e-03	2.276
Host Interactions of HIV factors	R-HSA-162909	5.448899e-03	2.264
Cilium Assembly	R-HSA-5617833	5.477099e-03	2.261
Nuclear Envelope Breakdown	R-HSA-2980766	5.452831e-03	2.263
Transcriptional Regulation by E2F6	R-HSA-8953750	6.231640e-03	2.205
Signaling by Hippo	R-HSA-2028269	6.354313e-03	2.197
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	6.383713e-03	2.195
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	6.766030e-03	2.170
Notch-HLH transcription pathway	R-HSA-350054	6.818993e-03	2.166
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	6.840466e-03	2.165
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	6.840466e-03	2.165
Membrane binding and targetting of GAG proteins	R-HSA-174490	6.936877e-03	2.159
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	7.004081e-03	2.155
Metabolism of RNA	R-HSA-8953854	7.210720e-03	2.142
Adherens junctions interactions	R-HSA-418990	7.315526e-03	2.136
Processing of DNA double-strand break ends	R-HSA-5693607	7.511307e-03	2.124
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	7.783065e-03	2.109
Dual Incision in GG-NER	R-HSA-5696400	7.783065e-03	2.109
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	7.850879e-03	2.105
Smooth Muscle Contraction	R-HSA-445355	7.850879e-03	2.105
DNA Double Strand Break Response	R-HSA-5693606	7.853001e-03	2.105
Depolymerization of the Nuclear Lamina	R-HSA-4419969	7.993845e-03	2.097
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	7.993845e-03	2.097
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	9.440060e-03	2.025
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	9.022522e-03	2.045
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.258738e-03	2.033
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	8.329700e-03	2.079
PKMTs methylate histone lysines	R-HSA-3214841	8.394304e-03	2.076
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	9.022522e-03	2.045
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	9.102525e-03	2.041
Apoptosis induced DNA fragmentation	R-HSA-140342	9.440060e-03	2.025
RNA Polymerase I Promoter Clearance	R-HSA-73854	9.526758e-03	2.021
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	9.022522e-03	2.045
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.392043e-03	2.076
Maturation of protein E	R-HSA-9683683	8.187900e-03	2.087
Maturation of protein E	R-HSA-9694493	8.187900e-03	2.087
Downregulation of ERBB2 signaling	R-HSA-8863795	9.692917e-03	2.014
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	9.875904e-03	2.005
MyD88-independent TLR4 cascade	R-HSA-166166	9.875904e-03	2.005
Translesion Synthesis by POLH	R-HSA-110320	9.925623e-03	2.003
Eukaryotic Translation Initiation	R-HSA-72613	1.008399e-02	1.996
Cap-dependent Translation Initiation	R-HSA-72737	1.008399e-02	1.996
PRC2 methylates histones and DNA	R-HSA-212300	1.058659e-02	1.975
FLT3 signaling in disease	R-HSA-9682385	1.058659e-02	1.975
Interleukin-17 signaling	R-HSA-448424	1.090011e-02	1.963
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.131800e-02	1.946
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.132215e-02	1.946
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	1.152172e-02	1.938
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.152172e-02	1.938
Translesion synthesis by REV1	R-HSA-110312	1.152172e-02	1.938
RNA Polymerase I Transcription	R-HSA-73864	1.166335e-02	1.933
mRNA Splicing - Major Pathway	R-HSA-72163	1.193858e-02	1.923
Interleukin-7 signaling	R-HSA-1266695	1.201492e-02	1.920
NoRC negatively regulates rRNA expression	R-HSA-427413	1.209970e-02	1.917
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.217715e-02	1.914
Degradation of DVL	R-HSA-4641258	1.224749e-02	1.912
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.228610e-02	1.911
Amplification of signal from the kinetochores	R-HSA-141424	1.228610e-02	1.911
Signaling by ROBO receptors	R-HSA-376176	1.244080e-02	1.905
ChREBP activates metabolic gene expression	R-HSA-163765	1.264952e-02	1.898
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.328163e-02	1.877
G0 and Early G1	R-HSA-1538133	1.334624e-02	1.875
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.339999e-02	1.873
Assembly of the pre-replicative complex	R-HSA-68867	1.396050e-02	1.855
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.422784e-02	1.847
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.426493e-02	1.846
RMTs methylate histone arginines	R-HSA-3214858	1.442084e-02	1.841
Translesion synthesis by POLI	R-HSA-5656121	1.447303e-02	1.839
Intracellular signaling by second messengers	R-HSA-9006925	1.450643e-02	1.838
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.656449e-02	1.781
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.477525e-02	1.830
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.477525e-02	1.830
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.551510e-02	1.809
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.614871e-02	1.792
mRNA 3'-end processing	R-HSA-72187	1.621847e-02	1.790
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.480629e-02	1.830
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.579598e-02	1.801
Regulation of necroptotic cell death	R-HSA-5675482	1.551510e-02	1.809
Ub-specific processing proteases	R-HSA-5689880	1.507455e-02	1.822
Regulation of TP53 Activity	R-HSA-5633007	1.761824e-02	1.754
Clathrin-mediated endocytosis	R-HSA-8856828	1.694245e-02	1.771
DNA Replication Pre-Initiation	R-HSA-69002	1.707933e-02	1.768
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.767278e-02	1.753
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.767278e-02	1.753
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.767278e-02	1.753
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.767278e-02	1.753
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.767278e-02	1.753
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.774572e-02	1.751
Assembly Of The HIV Virion	R-HSA-175474	1.774572e-02	1.751
Cell-cell junction organization	R-HSA-421270	1.785924e-02	1.748
Translesion synthesis by POLK	R-HSA-5655862	1.791273e-02	1.747
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.791273e-02	1.747
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.793220e-02	1.746
Protein ubiquitination	R-HSA-8852135	1.795836e-02	1.746
Centrosome maturation	R-HSA-380287	1.795836e-02	1.746
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.841321e-02	1.735
HIV Infection	R-HSA-162906	1.947573e-02	1.711
Ribosome-associated quality control	R-HSA-9948299	1.954595e-02	1.709
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.038156e-02	1.691
RAF activation	R-HSA-5673000	2.061216e-02	1.686
RAF/MAP kinase cascade	R-HSA-5673001	2.095920e-02	1.679
Disorders of Nervous System Development	R-HSA-9697154	2.111955e-02	1.675
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	2.111955e-02	1.675
Pervasive developmental disorders	R-HSA-9005895	2.111955e-02	1.675
VLDLR internalisation and degradation	R-HSA-8866427	2.111955e-02	1.675
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.111955e-02	1.675
IRAK1 recruits IKK complex	R-HSA-937039	2.111955e-02	1.675
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	2.111955e-02	1.675
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	2.111955e-02	1.675
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	2.111955e-02	1.675
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.117453e-02	1.674
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	2.138506e-02	1.670
Muscle contraction	R-HSA-397014	2.169991e-02	1.664
mRNA Splicing	R-HSA-72172	2.230350e-02	1.652
Termination of translesion DNA synthesis	R-HSA-5656169	2.284070e-02	1.641
DNA methylation	R-HSA-5334118	2.284070e-02	1.641
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.284070e-02	1.641
NGF-stimulated transcription	R-HSA-9031628	2.324510e-02	1.634
Modulation by Mtb of host immune system	R-HSA-9637628	2.337625e-02	1.631
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.361529e-02	1.627
Signaling by PTK6	R-HSA-8848021	2.397473e-02	1.620
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.397473e-02	1.620
Regulation of RAS by GAPs	R-HSA-5658442	2.889981e-02	1.539
Polo-like kinase mediated events	R-HSA-156711	2.638756e-02	1.579
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.638756e-02	1.579
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.912772e-02	1.536
RET signaling	R-HSA-8853659	2.681650e-02	1.572
HIV Life Cycle	R-HSA-162587	2.436376e-02	1.613
Late Phase of HIV Life Cycle	R-HSA-162599	2.691373e-02	1.570
Mitotic Spindle Checkpoint	R-HSA-69618	2.670069e-02	1.573
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.660245e-02	1.575
MAPK1/MAPK3 signaling	R-HSA-5684996	2.854381e-02	1.544
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.036713e-02	1.518
MAPK family signaling cascades	R-HSA-5683057	2.603707e-02	1.584
Organelle biogenesis and maintenance	R-HSA-1852241	2.565194e-02	1.591
Signaling by EGFR	R-HSA-177929	2.504998e-02	1.601
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.504998e-02	1.601
Defective pyroptosis	R-HSA-9710421	2.983421e-02	1.525
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.048708e-02	1.516
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.073592e-02	1.512
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	3.098293e-02	1.509
Signaling by Interleukins	R-HSA-449147	3.138320e-02	1.503
IKK complex recruitment mediated by RIP1	R-HSA-937041	3.147906e-02	1.502
Regulation of signaling by CBL	R-HSA-912631	3.147906e-02	1.502
DNA Double-Strand Break Repair	R-HSA-5693532	3.151846e-02	1.501
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	3.165429e-02	1.500
Meiotic recombination	R-HSA-912446	3.206938e-02	1.494
NRIF signals cell death from the nucleus	R-HSA-205043	3.262172e-02	1.486
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.311085e-02	1.480
Metabolism of non-coding RNA	R-HSA-194441	3.367595e-02	1.473
snRNP Assembly	R-HSA-191859	3.367595e-02	1.473
SWI/SNF chromatin remodelers	R-HSA-9932451	3.381485e-02	1.471
ATP-dependent chromatin remodelers	R-HSA-9932444	3.381485e-02	1.471
HDMs demethylate histones	R-HSA-3214842	3.381485e-02	1.471
RIPK1-mediated regulated necrosis	R-HSA-5213460	3.423290e-02	1.466
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.423290e-02	1.466
Neurexins and neuroligins	R-HSA-6794361	3.547812e-02	1.450
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	3.711157e-02	1.430
Nucleosome assembly	R-HSA-774815	3.711157e-02	1.430
Asymmetric localization of PCP proteins	R-HSA-4608870	3.711157e-02	1.430
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	3.717100e-02	1.430
Glycogen synthesis	R-HSA-3322077	3.717100e-02	1.430
Negative regulation of MET activity	R-HSA-6807004	3.717100e-02	1.430
CDC6 association with the ORC:origin complex	R-HSA-68689	4.406148e-02	1.356
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	4.406148e-02	1.356
PI3K/AKT activation	R-HSA-198203	3.931349e-02	1.405
MET activates RAP1 and RAC1	R-HSA-8875555	3.931349e-02	1.405
Folding of actin by CCT/TriC	R-HSA-390450	3.931349e-02	1.405
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	3.959126e-02	1.402
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	5.042376e-02	1.297
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.042376e-02	1.297
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.423346e-02	1.354
Condensation of Prophase Chromosomes	R-HSA-2299718	4.117525e-02	1.385
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	4.553312e-02	1.342
RNA Polymerase II Transcription Termination	R-HSA-73856	4.048954e-02	1.393
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	4.821285e-02	1.317
Loss of Nlp from mitotic centrosomes	R-HSA-380259	4.821285e-02	1.317
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.173172e-02	1.380
Signaling by EGFR in Cancer	R-HSA-1643713	3.897795e-02	1.409
Transcriptional Regulation by MECP2	R-HSA-8986944	3.878616e-02	1.411
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	4.782568e-02	1.320
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	4.348138e-02	1.362
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.295277e-02	1.367
Eukaryotic Translation Elongation	R-HSA-156842	4.483400e-02	1.348
Prolonged ERK activation events	R-HSA-169893	4.739968e-02	1.324
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.931349e-02	1.405
Negative feedback regulation of MAPK pathway	R-HSA-5674499	4.406148e-02	1.356
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	5.042376e-02	1.297
Hh mutants are degraded by ERAD	R-HSA-5362768	4.782568e-02	1.320
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.490447e-02	1.348
Regulation of PTEN stability and activity	R-HSA-8948751	3.913373e-02	1.407
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	4.406148e-02	1.356
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	4.970082e-02	1.304
TCF dependent signaling in response to WNT	R-HSA-201681	4.213799e-02	1.375
MyD88 cascade initiated on plasma membrane	R-HSA-975871	4.139804e-02	1.383
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	4.139804e-02	1.383
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	4.139804e-02	1.383
NOD1/2 Signaling Pathway	R-HSA-168638	4.970082e-02	1.304
Interactions of Rev with host cellular proteins	R-HSA-177243	4.295277e-02	1.367
Semaphorin interactions	R-HSA-373755	4.821285e-02	1.317
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	3.959126e-02	1.402
Spry regulation of FGF signaling	R-HSA-1295596	3.959126e-02	1.402
Interferon Signaling	R-HSA-913531	3.807035e-02	1.419
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.348138e-02	1.362
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	4.912010e-02	1.309
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	5.042376e-02	1.297
Pexophagy	R-HSA-9664873	3.931349e-02	1.405
Reproduction	R-HSA-1474165	5.217047e-02	1.283
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	5.226891e-02	1.282
Transcriptional regulation by small RNAs	R-HSA-5578749	5.269682e-02	1.278
rRNA processing in the nucleus and cytosol	R-HSA-8868773	5.368727e-02	1.270
Cytokine Signaling in Immune system	R-HSA-1280215	5.399247e-02	1.268
Oxidative Stress Induced Senescence	R-HSA-2559580	5.412266e-02	1.267
Mitotic G1 phase and G1/S transition	R-HSA-453279	5.481467e-02	1.261
DNA Damage Bypass	R-HSA-73893	5.515907e-02	1.258
Oncogene Induced Senescence	R-HSA-2559585	5.558759e-02	1.255
Peptide chain elongation	R-HSA-156902	5.595128e-02	1.252
Disorders of Developmental Biology	R-HSA-9675151	5.605632e-02	1.251
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	5.605632e-02	1.251
PIP3 activates AKT signaling	R-HSA-1257604	5.607082e-02	1.251
Vesicle-mediated transport	R-HSA-5653656	5.683077e-02	1.245
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	5.745015e-02	1.241
Signaling by CSF3 (G-CSF)	R-HSA-9674555	5.745015e-02	1.241
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	5.800722e-02	1.237
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	5.840964e-02	1.234
Regulation of TP53 Expression	R-HSA-6804754	5.840964e-02	1.234
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	5.840964e-02	1.234
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	5.840964e-02	1.234
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	5.840964e-02	1.234
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	5.840964e-02	1.234
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	5.840964e-02	1.234
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	5.840964e-02	1.234
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	5.840964e-02	1.234
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	5.840964e-02	1.234
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	5.840964e-02	1.234
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	5.840964e-02	1.234
CREB phosphorylation	R-HSA-199920	5.852460e-02	1.233
Ca-dependent events	R-HSA-111996	5.863585e-02	1.232
Formation of a pool of free 40S subunits	R-HSA-72689	5.887845e-02	1.230
Signaling by VEGF	R-HSA-194138	6.009759e-02	1.221
S Phase	R-HSA-69242	6.081446e-02	1.216
Dual incision in TC-NER	R-HSA-6782135	6.134444e-02	1.212
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	6.134444e-02	1.212
G2/M DNA damage checkpoint	R-HSA-69473	6.136479e-02	1.212
Opioid Signalling	R-HSA-111885	6.141275e-02	1.212
Response of endothelial cells to shear stress	R-HSA-9860931	6.141275e-02	1.212
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	6.141275e-02	1.212
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.141275e-02	1.212
AURKA Activation by TPX2	R-HSA-8854518	6.159555e-02	1.210
Homology Directed Repair	R-HSA-5693538	6.186129e-02	1.209
Vif-mediated degradation of APOBEC3G	R-HSA-180585	6.190018e-02	1.208
Calmodulin induced events	R-HSA-111933	6.190018e-02	1.208
CaM pathway	R-HSA-111997	6.190018e-02	1.208
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.408757e-02	1.193
Hh mutants abrogate ligand secretion	R-HSA-5387390	6.458475e-02	1.190
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	6.458475e-02	1.190
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	6.463084e-02	1.190
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	6.463084e-02	1.190
Loss of Function of TP53 in Cancer	R-HSA-9723907	9.250359e-02	1.034
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	9.250359e-02	1.034
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	9.250359e-02	1.034
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.250359e-02	1.034
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	8.575935e-02	1.067
Axonal growth stimulation	R-HSA-209563	8.575935e-02	1.067
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	7.237502e-02	1.140
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	6.556234e-02	1.183
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	8.708844e-02	1.060
Deadenylation of mRNA	R-HSA-429947	7.511118e-02	1.124
Trafficking of AMPA receptors	R-HSA-399719	7.233078e-02	1.141
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	7.233078e-02	1.141
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	7.233078e-02	1.141
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	7.233078e-02	1.141
SIRT1 negatively regulates rRNA expression	R-HSA-427359	6.864320e-02	1.163
Vpr-mediated nuclear import of PICs	R-HSA-180910	6.864320e-02	1.163
Integrin signaling	R-HSA-354192	8.928726e-02	1.049
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.928726e-02	1.049
IPs transport between nucleus and cytosol	R-HSA-1855170	8.928726e-02	1.049
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	7.195385e-02	1.143
Orc1 removal from chromatin	R-HSA-68949	7.195385e-02	1.143
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.464924e-02	1.072
Translation initiation complex formation	R-HSA-72649	8.476118e-02	1.072
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.053014e-02	1.043
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	6.843974e-02	1.165
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.794550e-02	1.108
Interleukin-9 signaling	R-HSA-8985947	9.310143e-02	1.031
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.477716e-02	1.023
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	9.310143e-02	1.031
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	8.928726e-02	1.049
PCP/CE pathway	R-HSA-4086400	8.143195e-02	1.089
Activation of ATR in response to replication stress	R-HSA-176187	8.928726e-02	1.049
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	7.141605e-02	1.146
Long-term potentiation	R-HSA-9620244	8.462759e-02	1.072
Activation of NF-kappaB in B cells	R-HSA-1169091	6.603589e-02	1.180
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.298350e-02	1.032
Axonal growth inhibition (RHOA activation)	R-HSA-193634	9.310143e-02	1.031
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	8.249610e-02	1.084
Frs2-mediated activation	R-HSA-170968	8.576127e-02	1.067
Signaling by FLT3 fusion proteins	R-HSA-9703465	9.477716e-02	1.023
Maternal to zygotic transition (MZT)	R-HSA-9816359	8.144103e-02	1.089
DAG and IP3 signaling	R-HSA-1489509	7.758958e-02	1.110
Protein-protein interactions at synapses	R-HSA-6794362	7.462402e-02	1.127
Regulation of TP53 Expression and Degradation	R-HSA-6806003	8.342945e-02	1.079
Stabilization of p53	R-HSA-69541	8.342945e-02	1.079
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.596304e-02	1.018
Circadian clock	R-HSA-9909396	9.142014e-02	1.039
MyD88 dependent cascade initiated on endosome	R-HSA-975155	8.721636e-02	1.059
Sema4D in semaphorin signaling	R-HSA-400685	8.462759e-02	1.072
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.985057e-02	1.098
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	8.575935e-02	1.067
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	8.576127e-02	1.067
EGFR downregulation	R-HSA-182971	7.233078e-02	1.141
Signaling by ALK	R-HSA-201556	8.342945e-02	1.079
Interactions of Vpr with host cellular proteins	R-HSA-176033	9.147248e-02	1.039
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.758958e-02	1.110
FGFR1 mutant receptor activation	R-HSA-1839124	8.928726e-02	1.049
Signaling by NOTCH1	R-HSA-1980143	7.093631e-02	1.149
Assembly of the ORC complex at the origin of replication	R-HSA-68616	8.928726e-02	1.049
Signaling by MET	R-HSA-6806834	9.286449e-02	1.032
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.928726e-02	1.049
Transport to the Golgi and subsequent modification	R-HSA-948021	9.778390e-02	1.010
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.539997e-02	1.069
Uptake and function of diphtheria toxin	R-HSA-5336415	7.492151e-02	1.125
Glycogen storage diseases	R-HSA-3229121	6.556234e-02	1.183
G1/S Transition	R-HSA-69206	9.495923e-02	1.022
Regulation of PD-L1(CD274) expression	R-HSA-9909648	8.631784e-02	1.064
Glycolysis	R-HSA-70171	8.032282e-02	1.095
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.233078e-02	1.141
Evasion by RSV of host interferon responses	R-HSA-9833109	7.233078e-02	1.141
NS1 Mediated Effects on Host Pathways	R-HSA-168276	8.342945e-02	1.079
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.147248e-02	1.039
Transcriptional regulation of granulopoiesis	R-HSA-9616222	8.411833e-02	1.075
ABC-family proteins mediated transport	R-HSA-382556	8.032282e-02	1.095
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.723061e-02	1.012
Sodium/Proton exchangers	R-HSA-425986	9.310143e-02	1.031
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.864320e-02	1.163
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	7.416492e-02	1.130
Sensory processing of sound	R-HSA-9659379	8.703062e-02	1.060
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	7.176364e-02	1.144
DNA Damage Recognition in GG-NER	R-HSA-5696394	9.853645e-02	1.006
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	9.853645e-02	1.006
Vpu mediated degradation of CD4	R-HSA-180534	9.853645e-02	1.006
Eukaryotic Translation Termination	R-HSA-72764	9.864859e-02	1.006
Ribosomal scanning and start codon recognition	R-HSA-72702	9.886840e-02	1.005
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	9.907361e-02	1.004
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	9.988224e-02	1.001
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	9.988224e-02	1.001
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.994553e-02	1.000
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.002564e-01	0.999
Switching of origins to a post-replicative state	R-HSA-69052	1.016840e-01	0.993
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.024028e-01	0.990
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.024028e-01	0.990
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.037140e-01	0.984
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.037140e-01	0.984
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.043758e-01	0.981
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	1.055475e-01	0.977
Interaction between L1 and Ankyrins	R-HSA-445095	1.055475e-01	0.977
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	1.055475e-01	0.977
RNA Polymerase I Promoter Opening	R-HSA-73728	1.055475e-01	0.977
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	1.078081e-01	0.967
Signaling by NOTCH2	R-HSA-1980145	1.082903e-01	0.965
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.082903e-01	0.965
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.082903e-01	0.965
Nuclear import of Rev protein	R-HSA-180746	1.082903e-01	0.965
Signaling by NOTCH4	R-HSA-9013694	1.084449e-01	0.965
Signaling by FGFR1 in disease	R-HSA-5655302	1.088439e-01	0.963
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.118395e-01	0.951
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.118395e-01	0.951
Zygotic genome activation (ZGA)	R-HSA-9819196	1.118395e-01	0.951
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.118395e-01	0.951
Calcineurin activates NFAT	R-HSA-2025928	1.128944e-01	0.947
ALK mutants bind TKIs	R-HSA-9700645	1.128944e-01	0.947
p75NTR regulates axonogenesis	R-HSA-193697	1.128944e-01	0.947
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.128944e-01	0.947
Butyrophilin (BTN) family interactions	R-HSA-8851680	1.128944e-01	0.947
Cellular responses to mechanical stimuli	R-HSA-9855142	1.133849e-01	0.945
Chromosome Maintenance	R-HSA-73886	1.143822e-01	0.942
Influenza Infection	R-HSA-168255	1.153011e-01	0.938
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.154629e-01	0.938
Iron uptake and transport	R-HSA-917937	1.154629e-01	0.938
DCC mediated attractive signaling	R-HSA-418885	1.157991e-01	0.936
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.157991e-01	0.936
DNA Replication	R-HSA-69306	1.158961e-01	0.936
Signaling by WNT	R-HSA-195721	1.159772e-01	0.936
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.161075e-01	0.935
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.161075e-01	0.935
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.161075e-01	0.935
Signaling by MAP2K mutants	R-HSA-9652169	1.161075e-01	0.935
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	1.169227e-01	0.932
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.181611e-01	0.928
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.185389e-01	0.926
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	1.185389e-01	0.926
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	1.185389e-01	0.926
Regulation of Apoptosis	R-HSA-169911	1.185389e-01	0.926
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.190527e-01	0.924
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.199568e-01	0.921
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.199568e-01	0.921
Deadenylation-dependent mRNA decay	R-HSA-429914	1.224431e-01	0.912
UCH proteinases	R-HSA-5689603	1.227362e-01	0.911
HATs acetylate histones	R-HSA-3214847	1.227454e-01	0.911
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.253535e-01	0.902
Signaling by PDGFR in disease	R-HSA-9671555	1.253535e-01	0.902
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.253535e-01	0.902
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.253535e-01	0.902
Hedgehog ligand biogenesis	R-HSA-5358346	1.254734e-01	0.901
MAPK6/MAPK4 signaling	R-HSA-5687128	1.255549e-01	0.901
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.268927e-01	0.897
Regulated Necrosis	R-HSA-5218859	1.268927e-01	0.897
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.288830e-01	0.890
DARPP-32 events	R-HSA-180024	1.288830e-01	0.890
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.288830e-01	0.890
Regulation of TP53 Degradation	R-HSA-6804757	1.292696e-01	0.889
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.323194e-01	0.878
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.323194e-01	0.878
Regulation of BACH1 activity	R-HSA-9708530	1.323194e-01	0.878
Negative regulation of FLT3	R-HSA-9706369	1.323194e-01	0.878
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.341189e-01	0.873
Signaling by Leptin	R-HSA-2586552	1.341189e-01	0.873
RNA Polymerase I Promoter Escape	R-HSA-73772	1.347145e-01	0.871
Diseases of Telomere Maintenance	R-HSA-9673013	1.764552e-01	0.753
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.764552e-01	0.753
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.764552e-01	0.753
Blockage of phagosome acidification	R-HSA-9636467	1.764552e-01	0.753
Hereditary fructose intolerance	R-HSA-5657560	1.764552e-01	0.753
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.764552e-01	0.753
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.764552e-01	0.753
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.764552e-01	0.753
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.764552e-01	0.753
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.526451e-01	0.597
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.526451e-01	0.597
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	2.526451e-01	0.597
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.526451e-01	0.597
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	2.526451e-01	0.597
IKBKB deficiency causes SCID	R-HSA-5602636	2.526451e-01	0.597
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)	R-HSA-5619045	2.526451e-01	0.597
Defective SLC34A2 causes PALM	R-HSA-5687583	2.526451e-01	0.597
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.526451e-01	0.597
IRS activation	R-HSA-74713	1.486661e-01	0.828
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.486661e-01	0.828
IkBA variant leads to EDA-ID	R-HSA-5603029	1.827671e-01	0.738
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	1.827671e-01	0.738
Signaling by LTK in cancer	R-HSA-9842640	2.178471e-01	0.662
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	2.178471e-01	0.662
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.565881e-01	0.805
Signaling by APC mutants	R-HSA-4839744	1.565881e-01	0.805
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.565881e-01	0.805
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.565881e-01	0.805
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.565881e-01	0.805
Signaling by GSK3beta mutants	R-HSA-5339716	1.801145e-01	0.744
MECP2 regulates transcription factors	R-HSA-9022707	2.534335e-01	0.596
Activated NTRK2 signals through CDK5	R-HSA-9032845	2.534335e-01	0.596
MET activates PI3K/AKT signaling	R-HSA-8851907	2.534335e-01	0.596
TRIF-mediated programmed cell death	R-HSA-2562578	2.534335e-01	0.596
SOS-mediated signalling	R-HSA-112412	2.534335e-01	0.596
Disinhibition of SNARE formation	R-HSA-114516	2.534335e-01	0.596
G beta:gamma signalling through CDC42	R-HSA-8964616	1.497405e-01	0.825
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.045139e-01	0.689
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.045139e-01	0.689
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.045139e-01	0.689
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.045139e-01	0.689
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.045139e-01	0.689
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.045139e-01	0.689
FGFR2 alternative splicing	R-HSA-6803529	1.395780e-01	0.855
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.296085e-01	0.639
GAB1 signalosome	R-HSA-180292	1.869547e-01	0.728
Ephrin signaling	R-HSA-3928664	1.869547e-01	0.728
Activation of the pre-replicative complex	R-HSA-68962	1.414059e-01	0.850
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.065752e-01	0.685
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.267542e-01	0.644
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.267542e-01	0.644
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.267542e-01	0.644
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.267542e-01	0.644
Packaging Of Telomere Ends	R-HSA-171306	2.197882e-01	0.658
Cristae formation	R-HSA-8949613	2.197882e-01	0.658
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.766918e-01	0.753
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.594310e-01	0.797
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.442988e-01	0.841
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.895754e-01	0.722
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	1.895754e-01	0.722
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.706886e-01	0.768
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.542173e-01	0.812
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.750156e-01	0.757
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.318401e-01	0.635
Formation of RNA Pol II elongation complex	R-HSA-112382	2.318401e-01	0.635
RNA Polymerase II Transcription Elongation	R-HSA-75955	2.449146e-01	0.611
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.449146e-01	0.611
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	2.717481e-01	0.566
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	2.300752e-01	0.638
Viral mRNA Translation	R-HSA-192823	2.241310e-01	0.649
Neutrophil degranulation	R-HSA-6798695	2.204248e-01	0.657
Nucleotide Excision Repair	R-HSA-5696398	2.521286e-01	0.598
Interleukin-15 signaling	R-HSA-8983432	2.045139e-01	0.689
EPHB-mediated forward signaling	R-HSA-3928662	1.380177e-01	0.860
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.402486e-01	0.853
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.896639e-01	0.722
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.589973e-01	0.587
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.543110e-01	0.595
Integration of provirus	R-HSA-162592	1.801145e-01	0.744
Rap1 signalling	R-HSA-392517	2.065752e-01	0.685
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.449146e-01	0.611
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.486661e-01	0.828
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.026979e-01	0.693
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	1.485360e-01	0.828
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.114821e-01	0.675
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	2.697309e-01	0.569
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.551749e-01	0.593
mTORC1-mediated signalling	R-HSA-166208	1.395780e-01	0.855
Transcriptional Regulation by TP53	R-HSA-3700989	1.399791e-01	0.854
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.383385e-01	0.623
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	2.197882e-01	0.658
Beta-catenin independent WNT signaling	R-HSA-3858494	1.691060e-01	0.772
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.641984e-01	0.785
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.433994e-01	0.843
G-protein mediated events	R-HSA-112040	1.985218e-01	0.702
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.711338e-01	0.767
Activation and oligomerization of BAK protein	R-HSA-111452	1.764552e-01	0.753
Abacavir transmembrane transport	R-HSA-2161517	2.178471e-01	0.662
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.045139e-01	0.689
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.820819e-01	0.740
Fanconi Anemia Pathway	R-HSA-6783310	1.485360e-01	0.828
Degradation of CRY and PER proteins	R-HSA-9932298	2.028259e-01	0.693
Interleukin-1 signaling	R-HSA-9020702	1.359714e-01	0.867
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.543597e-01	0.811
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.827671e-01	0.738
Activated NTRK3 signals through PI3K	R-HSA-9603381	2.534335e-01	0.596
DNA Repair	R-HSA-73894	1.360389e-01	0.866
PLC beta mediated events	R-HSA-112043	1.397270e-01	0.855
Synthesis of DNA	R-HSA-69239	2.714835e-01	0.566
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.178471e-01	0.662
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.895754e-01	0.722
Cellular response to starvation	R-HSA-9711097	2.695982e-01	0.569
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.263578e-01	0.645
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.497405e-01	0.825
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.942290e-01	0.712
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.942290e-01	0.712
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.267663e-01	0.644
Toll-like Receptor Cascades	R-HSA-168898	2.376313e-01	0.624
Mitophagy	R-HSA-5205647	2.114821e-01	0.675
Activation, translocation and oligomerization of BAX	R-HSA-114294	1.764552e-01	0.753
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.526451e-01	0.597
Manipulation of host energy metabolism	R-HSA-9636667	2.526451e-01	0.597
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	1.486661e-01	0.828
Sodium-coupled phosphate cotransporters	R-HSA-427652	1.827671e-01	0.738
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.801145e-01	0.744
Signaling by AXIN mutants	R-HSA-4839735	1.801145e-01	0.744
Signaling by AMER1 mutants	R-HSA-4839748	1.801145e-01	0.744
Cation-coupled Chloride cotransporters	R-HSA-426117	2.534335e-01	0.596
Signaling by LTK	R-HSA-9842663	2.045139e-01	0.689
Regulation of FZD by ubiquitination	R-HSA-4641263	1.679807e-01	0.775
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.544713e-01	0.811
Degradation of AXIN	R-HSA-4641257	1.404679e-01	0.852
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.404679e-01	0.852
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.114821e-01	0.675
Degradation of GLI1 by the proteasome	R-HSA-5610780	2.028259e-01	0.693
Platelet calcium homeostasis	R-HSA-418360	2.551749e-01	0.593
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.589973e-01	0.587
rRNA processing	R-HSA-72312	2.611046e-01	0.583
Adipogenesis	R-HSA-9843745	2.670112e-01	0.573
Estrogen-dependent gene expression	R-HSA-9018519	1.691060e-01	0.772
Transcriptional regulation by RUNX3	R-HSA-8878159	2.557323e-01	0.592
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.869547e-01	0.728
Transmission across Chemical Synapses	R-HSA-112315	1.793748e-01	0.746
Platelet degranulation	R-HSA-114608	1.567197e-01	0.805
Signaling by NOTCH	R-HSA-157118	1.458285e-01	0.836
ERK/MAPK targets	R-HSA-198753	2.474039e-01	0.607
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	1.641984e-01	0.785
Downstream TCR signaling	R-HSA-202424	2.592903e-01	0.586
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.534335e-01	0.596
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.594310e-01	0.797
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	2.028259e-01	0.693
Degradation of GLI2 by the proteasome	R-HSA-5610783	2.028259e-01	0.693
Degradation of CDH1	R-HSA-9766229	1.942290e-01	0.712
Signal transduction by L1	R-HSA-445144	2.267542e-01	0.644
Amyloid fiber formation	R-HSA-977225	1.628156e-01	0.788
Regulation of T cell activation by CD28 family	R-HSA-388841	2.301326e-01	0.638
Co-inhibition by PD-1	R-HSA-389948	2.338355e-01	0.631
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.372984e-01	0.625
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.551749e-01	0.593
Glucose metabolism	R-HSA-70326	2.109807e-01	0.676
FLT3 Signaling	R-HSA-9607240	1.895754e-01	0.722
Signaling by FGFR2	R-HSA-5654738	1.543185e-01	0.812
Reduction of cytosolic Ca++ levels	R-HSA-418359	1.801145e-01	0.744
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.197882e-01	0.658
Negative regulation of NOTCH4 signaling	R-HSA-9604323	1.766918e-01	0.753
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.895754e-01	0.722
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.808158e-01	0.743
Signaling by TGFB family members	R-HSA-9006936	2.130472e-01	0.672
Signaling by ERBB4	R-HSA-1236394	1.795666e-01	0.746
Potential therapeutics for SARS	R-HSA-9679191	2.087349e-01	0.680
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.433994e-01	0.843
Cyclin E associated events during G1/S transition	R-HSA-69202	2.313582e-01	0.636
Signaling by FGFR4	R-HSA-5654743	2.303296e-01	0.638
TCR signaling	R-HSA-202403	1.435143e-01	0.843
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.178471e-01	0.662
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.267663e-01	0.644
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.445312e-01	0.612
tRNA processing in the nucleus	R-HSA-6784531	2.441899e-01	0.612
Selenocysteine synthesis	R-HSA-2408557	2.062357e-01	0.686
Viral Infection Pathways	R-HSA-9824446	1.609250e-01	0.793
Signaling by FGFR3	R-HSA-5654741	2.589973e-01	0.587
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.892255e-01	0.723
Hedgehog 'on' state	R-HSA-5632684	1.520562e-01	0.818
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.609743e-01	0.793
NADPH regeneration	R-HSA-389542	2.178471e-01	0.662
Sodium/Calcium exchangers	R-HSA-425561	1.801145e-01	0.744
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.534335e-01	0.596
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.895754e-01	0.722
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	2.026979e-01	0.693
SARS-CoV-1-host interactions	R-HSA-9692914	2.617418e-01	0.582
ER Quality Control Compartment (ERQC)	R-HSA-901032	2.197882e-01	0.658
Transcriptional Regulation by NPAS4	R-HSA-9634815	2.318401e-01	0.635
G1/S-Specific Transcription	R-HSA-69205	2.423921e-01	0.615
Nef and signal transduction	R-HSA-164944	2.178471e-01	0.662
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.497405e-01	0.825
MITF-M-regulated melanocyte development	R-HSA-9730414	2.635200e-01	0.579
Signaling by NOTCH3	R-HSA-9012852	2.717481e-01	0.566
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.869547e-01	0.728
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.474039e-01	0.607
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	2.589973e-01	0.587
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	2.589973e-01	0.587
Suppression of phagosomal maturation	R-HSA-9637687	2.026979e-01	0.693
NPAS4 regulates expression of target genes	R-HSA-9768919	2.114821e-01	0.675
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	2.114821e-01	0.675
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	2.318401e-01	0.635
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	2.474039e-01	0.607
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	2.114821e-01	0.675
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.395780e-01	0.855
XBP1(S) activates chaperone genes	R-HSA-381038	2.184037e-01	0.661
Gene Silencing by RNA	R-HSA-211000	2.714835e-01	0.566
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.733640e-01	0.563
Activation of BH3-only proteins	R-HSA-114452	2.733640e-01	0.563
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	2.737005e-01	0.563
Regulation of pyruvate metabolism	R-HSA-9861718	2.737005e-01	0.563
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	2.745221e-01	0.561
SLC-mediated transport of inorganic anions	R-HSA-9958790	2.745221e-01	0.561
IRE1alpha activates chaperones	R-HSA-381070	2.806695e-01	0.552
Platelet activation, signaling and aggregation	R-HSA-76002	2.807152e-01	0.552
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.812144e-01	0.551
Beta-catenin phosphorylation cascade	R-HSA-196299	2.812144e-01	0.551
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.812144e-01	0.551
Protein methylation	R-HSA-8876725	2.812144e-01	0.551
Biotin transport and metabolism	R-HSA-196780	2.812144e-01	0.551
MITF-M-dependent gene expression	R-HSA-9856651	2.827935e-01	0.549
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.854649e-01	0.544
Ion homeostasis	R-HSA-5578775	2.854649e-01	0.544
Transcriptional regulation by RUNX1	R-HSA-8878171	2.862431e-01	0.543
ROBO receptors bind AKAP5	R-HSA-9010642	2.891327e-01	0.539
Type I hemidesmosome assembly	R-HSA-446107	2.891327e-01	0.539
Regulation by c-FLIP	R-HSA-3371378	2.891327e-01	0.539
RSK activation	R-HSA-444257	2.891327e-01	0.539
Dimerization of procaspase-8	R-HSA-69416	2.891327e-01	0.539
Formation of annular gap junctions	R-HSA-196025	2.891327e-01	0.539
Activated NTRK2 signals through PI3K	R-HSA-9028335	2.891327e-01	0.539
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	2.891327e-01	0.539
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.891327e-01	0.539
Adrenoceptors	R-HSA-390696	2.891327e-01	0.539
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.891327e-01	0.539
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.897716e-01	0.538
Plasma lipoprotein clearance	R-HSA-8964043	2.909521e-01	0.536
EPH-Ephrin signaling	R-HSA-2682334	2.915588e-01	0.535
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.918123e-01	0.535
Downstream signal transduction	R-HSA-186763	2.918123e-01	0.535
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.968513e-01	0.527
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.993532e-01	0.524
Gluconeogenesis	R-HSA-70263	3.037086e-01	0.518
Metal ion SLC transporters	R-HSA-425410	3.037086e-01	0.518
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	3.074173e-01	0.512
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.074173e-01	0.512
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	3.074173e-01	0.512
Glycogen metabolism	R-HSA-8982491	3.075760e-01	0.512
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	3.075760e-01	0.512
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	3.075760e-01	0.512
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	3.104673e-01	0.508
Syndecan interactions	R-HSA-3000170	3.113236e-01	0.507
Growth hormone receptor signaling	R-HSA-982772	3.113236e-01	0.507
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	3.113236e-01	0.507
Neuronal System	R-HSA-112316	3.206255e-01	0.494
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.217904e-01	0.492
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.217904e-01	0.492
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.217904e-01	0.492
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.217904e-01	0.492
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.217904e-01	0.492
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.217904e-01	0.492
DSCAM interactions	R-HSA-376172	3.217904e-01	0.492
ARMS-mediated activation	R-HSA-170984	3.246196e-01	0.489
WNT mediated activation of DVL	R-HSA-201688	3.246196e-01	0.489
Gap junction degradation	R-HSA-190873	3.246196e-01	0.489
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	3.246196e-01	0.489
CASP8 activity is inhibited	R-HSA-5218900	3.246196e-01	0.489
Interleukin-21 signaling	R-HSA-9020958	3.246196e-01	0.489
Regulation of NPAS4 gene transcription	R-HSA-9768777	3.246196e-01	0.489
Cellular response to mitochondrial stress	R-HSA-9840373	3.246196e-01	0.489
GP1b-IX-V activation signalling	R-HSA-430116	3.246196e-01	0.489
Respiratory syncytial virus genome replication	R-HSA-9834752	3.246196e-01	0.489
G-protein beta:gamma signalling	R-HSA-397795	3.292777e-01	0.482
Negative regulation of FGFR1 signaling	R-HSA-5654726	3.292777e-01	0.482
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.292777e-01	0.482
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	3.303726e-01	0.481
Pyruvate metabolism	R-HSA-70268	3.320674e-01	0.479
Pre-NOTCH Expression and Processing	R-HSA-1912422	3.322001e-01	0.479
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.330157e-01	0.478
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.337000e-01	0.477
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	3.412595e-01	0.467
HCMV Late Events	R-HSA-9610379	3.432602e-01	0.464
Unfolded Protein Response (UPR)	R-HSA-381119	3.491468e-01	0.457
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	3.498111e-01	0.456
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	3.522600e-01	0.453
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	3.547734e-01	0.450
Regulation of RUNX2 expression and activity	R-HSA-8939902	3.561904e-01	0.448
MTOR signalling	R-HSA-165159	3.582476e-01	0.446
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	3.582476e-01	0.446
Cleavage of the damaged pyrimidine	R-HSA-110329	3.582476e-01	0.446
Depyrimidination	R-HSA-73928	3.582476e-01	0.446
2-LTR circle formation	R-HSA-164843	3.596281e-01	0.444
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	3.596281e-01	0.444
Signal attenuation	R-HSA-74749	3.596281e-01	0.444
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.596281e-01	0.444
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.596281e-01	0.444
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.599374e-01	0.444
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.599374e-01	0.444
PI3K events in ERBB2 signaling	R-HSA-1963642	3.599374e-01	0.444
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	3.599374e-01	0.444
Uptake and function of anthrax toxins	R-HSA-5210891	3.599374e-01	0.444
Regulation of mitotic cell cycle	R-HSA-453276	3.610979e-01	0.442
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.610979e-01	0.442
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	3.610979e-01	0.442
ESR-mediated signaling	R-HSA-8939211	3.657696e-01	0.437
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	3.671664e-01	0.435
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	3.671664e-01	0.435
Negative regulation of FGFR2 signaling	R-HSA-5654727	3.671664e-01	0.435
Calnexin/calreticulin cycle	R-HSA-901042	3.671664e-01	0.435
Signaling by FGFR	R-HSA-190236	3.705409e-01	0.431
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.706136e-01	0.431
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	3.706136e-01	0.431
Cellular response to chemical stress	R-HSA-9711123	3.733684e-01	0.428
Signaling by SCF-KIT	R-HSA-1433557	3.752870e-01	0.426
Response of Mtb to phagocytosis	R-HSA-9637690	3.752870e-01	0.426
Myogenesis	R-HSA-525793	3.765266e-01	0.424
MET activates STAT3	R-HSA-8875791	3.845421e-01	0.415
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.845421e-01	0.415
Signalling to STAT3	R-HSA-198745	3.845421e-01	0.415
MET activates PTPN11	R-HSA-8865999	3.845421e-01	0.415
FasL/ CD95L signaling	R-HSA-75157	3.845421e-01	0.415
Type II Na+/Pi cotransporters	R-HSA-427589	3.845421e-01	0.415
Activation of BIM and translocation to mitochondria	R-HSA-111446	3.845421e-01	0.415
MET interacts with TNS proteins	R-HSA-8875513	3.845421e-01	0.415
rRNA modification in the nucleus and cytosol	R-HSA-6790901	3.850803e-01	0.414
G1/S DNA Damage Checkpoints	R-HSA-69615	3.850803e-01	0.414
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.858763e-01	0.414
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.858763e-01	0.414
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.858763e-01	0.414
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.860161e-01	0.413
Platelet sensitization by LDL	R-HSA-432142	3.860161e-01	0.413
Signalling to ERKs	R-HSA-187687	3.861502e-01	0.413
Interleukin-1 family signaling	R-HSA-446652	3.877618e-01	0.411
Formation of the posterior neural plate	R-HSA-9832991	3.939431e-01	0.405
Bicarbonate transporters	R-HSA-425381	3.939431e-01	0.405
RNA Polymerase I Transcription Termination	R-HSA-73863	3.982094e-01	0.400
EPHA-mediated growth cone collapse	R-HSA-3928663	3.982094e-01	0.400
Signaling by NTRK2 (TRKB)	R-HSA-9006115	3.982094e-01	0.400
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.017342e-01	0.396
Signaling by FGFR in disease	R-HSA-1226099	4.017342e-01	0.396
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	4.093872e-01	0.388
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.093872e-01	0.388
E2F mediated regulation of DNA replication	R-HSA-113510	4.118346e-01	0.385
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.118346e-01	0.385
The NLRP3 inflammasome	R-HSA-844456	4.118346e-01	0.385
Cellular response to hypoxia	R-HSA-1234174	4.140635e-01	0.383
Cleavage of the damaged purine	R-HSA-110331	4.239758e-01	0.373
Diseases of DNA repair	R-HSA-9675135	4.263847e-01	0.370
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.273934e-01	0.369
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.273934e-01	0.369
Signaling by FGFR1	R-HSA-5654736	4.277766e-01	0.369
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	4.289578e-01	0.368
Hemostasis	R-HSA-109582	4.304104e-01	0.366
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	4.373028e-01	0.359
Signaling by Erythropoietin	R-HSA-9006335	4.411237e-01	0.355
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.414910e-01	0.355
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.414910e-01	0.355
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.414910e-01	0.355
Defective LFNG causes SCDO3	R-HSA-5083630	4.414910e-01	0.355
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.414910e-01	0.355
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.414910e-01	0.355
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.414910e-01	0.355
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.414910e-01	0.355
Sensory perception of sour taste	R-HSA-9729555	4.414910e-01	0.355
TNFR1-mediated ceramide production	R-HSA-5626978	4.414910e-01	0.355
Dopamine receptors	R-HSA-390651	4.414910e-01	0.355
MET promotes cell motility	R-HSA-8875878	4.427362e-01	0.354
Depurination	R-HSA-73927	4.427362e-01	0.354
RSV-host interactions	R-HSA-9833110	4.517643e-01	0.345
ABC transporter disorders	R-HSA-5619084	4.559531e-01	0.341
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	4.598453e-01	0.337
RUNX3 regulates p14-ARF	R-HSA-8951936	4.598453e-01	0.337
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.598453e-01	0.337
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	4.598453e-01	0.337
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.598453e-01	0.337
Co-stimulation by CD28	R-HSA-389356	4.601270e-01	0.337
Early Phase of HIV Life Cycle	R-HSA-162594	4.623416e-01	0.335
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.652581e-01	0.332
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	4.768170e-01	0.322
Telomere Maintenance	R-HSA-157579	4.773318e-01	0.321
Interleukin-2 family signaling	R-HSA-451927	4.797670e-01	0.319
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.868826e-01	0.313
Mitochondrial calcium ion transport	R-HSA-8949215	4.868826e-01	0.313
Post-translational protein phosphorylation	R-HSA-8957275	4.893519e-01	0.310
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.911972e-01	0.309
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	4.911972e-01	0.309
PI5P Regulates TP53 Acetylation	R-HSA-6811555	4.911972e-01	0.309
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	4.911972e-01	0.309
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	4.931734e-01	0.307
NrCAM interactions	R-HSA-447038	4.931734e-01	0.307
Reelin signalling pathway	R-HSA-8866376	4.931734e-01	0.307
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	4.931734e-01	0.307
PTK6 Activates STAT3	R-HSA-8849474	4.931734e-01	0.307
PTK6 Down-Regulation	R-HSA-8849472	4.931734e-01	0.307
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.931734e-01	0.307
Muscarinic acetylcholine receptors	R-HSA-390648	4.931734e-01	0.307
Inositol transporters	R-HSA-429593	4.931734e-01	0.307
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.931734e-01	0.307
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.931734e-01	0.307
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	4.931734e-01	0.307
PI3K Cascade	R-HSA-109704	4.933524e-01	0.307
Adaptive Immune System	R-HSA-1280218	4.967988e-01	0.304
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.978422e-01	0.303
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.979709e-01	0.303
IRS-related events triggered by IGF1R	R-HSA-2428928	5.045205e-01	0.297
Viral Messenger RNA Synthesis	R-HSA-168325	5.045205e-01	0.297
RAF-independent MAPK1/3 activation	R-HSA-112409	5.108669e-01	0.292
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	5.108669e-01	0.292
Ethanol oxidation	R-HSA-71384	5.108669e-01	0.292
trans-Golgi Network Vesicle Budding	R-HSA-199992	5.140589e-01	0.289
SARS-CoV-1 Infection	R-HSA-9678108	5.154359e-01	0.288
Translation of Structural Proteins	R-HSA-9683701	5.159271e-01	0.287
Heme signaling	R-HSA-9707616	5.194898e-01	0.284
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.213749e-01	0.283
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	5.213749e-01	0.283
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77350	5.213749e-01	0.283
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77310	5.213749e-01	0.283
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77348	5.213749e-01	0.283
Signaling by FGFR4 in disease	R-HSA-5655291	5.213749e-01	0.283
Acyl chain remodeling of CL	R-HSA-1482798	5.213749e-01	0.283
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	5.224255e-01	0.282
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.237280e-01	0.281
Nuclear RNA decay	R-HSA-9930044	5.237280e-01	0.281
Uptake and actions of bacterial toxins	R-HSA-5339562	5.258671e-01	0.279
Interleukin receptor SHC signaling	R-HSA-912526	5.342452e-01	0.272
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.342452e-01	0.272
Interleukin-20 family signaling	R-HSA-8854691	5.342452e-01	0.272
Plus-strand DNA synthesis	R-HSA-164525	5.400761e-01	0.268
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.400761e-01	0.268
PKB-mediated events	R-HSA-109703	5.400761e-01	0.268
PDE3B signalling	R-HSA-165160	5.400761e-01	0.268
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	5.400761e-01	0.268
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	5.400761e-01	0.268
TRAIL signaling	R-HSA-75158	5.400761e-01	0.268
NGF-independant TRKA activation	R-HSA-187024	5.400761e-01	0.268
Signalling to p38 via RIT and RIN	R-HSA-187706	5.400761e-01	0.268
CLEC7A/inflammasome pathway	R-HSA-5660668	5.400761e-01	0.268
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	5.400761e-01	0.268
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	5.400761e-01	0.268
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.400761e-01	0.268
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.400761e-01	0.268
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	5.408067e-01	0.267
Resolution of D-Loop Structures	R-HSA-5693537	5.434659e-01	0.265
Glucagon signaling in metabolic regulation	R-HSA-163359	5.434659e-01	0.265
Effects of PIP2 hydrolysis	R-HSA-114508	5.434659e-01	0.265
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	5.434659e-01	0.265
IGF1R signaling cascade	R-HSA-2428924	5.489064e-01	0.261
Ion transport by P-type ATPases	R-HSA-936837	5.489064e-01	0.261
Erythropoietin activates RAS	R-HSA-9027284	5.503273e-01	0.259
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.503273e-01	0.259
G beta:gamma signalling through BTK	R-HSA-8964315	5.503273e-01	0.259
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.503273e-01	0.259
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.503273e-01	0.259
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.503273e-01	0.259
Formation of the anterior neural plate	R-HSA-9823739	5.503273e-01	0.259
TBC/RABGAPs	R-HSA-8854214	5.509917e-01	0.259
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	5.552345e-01	0.256
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	5.569764e-01	0.254
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	5.569764e-01	0.254
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	5.575033e-01	0.254
Base-Excision Repair, AP Site Formation	R-HSA-73929	5.575033e-01	0.254
Translation	R-HSA-72766	5.624886e-01	0.250
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	5.633232e-01	0.249
Netrin-1 signaling	R-HSA-373752	5.680538e-01	0.246
Proteasome assembly	R-HSA-9907900	5.680538e-01	0.246
Cyclin D associated events in G1	R-HSA-69231	5.680538e-01	0.246
G1 Phase	R-HSA-69236	5.680538e-01	0.246
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.680538e-01	0.246
Activation of HOX genes during differentiation	R-HSA-5619507	5.712022e-01	0.243
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	5.712022e-01	0.243
C-type lectin receptors (CLRs)	R-HSA-5621481	5.729201e-01	0.242
Developmental Biology	R-HSA-1266738	5.734511e-01	0.242
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	5.780226e-01	0.238
Class I peroxisomal membrane protein import	R-HSA-9603798	5.780226e-01	0.238
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	5.780226e-01	0.238
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.780226e-01	0.238
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.780226e-01	0.238
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	5.780226e-01	0.238
Killing mechanisms	R-HSA-9664420	5.780226e-01	0.238
Activation of SMO	R-HSA-5635838	5.780226e-01	0.238
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	5.780226e-01	0.238
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.790276e-01	0.237
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	5.790276e-01	0.237
TGFBR3 expression	R-HSA-9839394	5.790276e-01	0.237
Translation of Structural Proteins	R-HSA-9694635	5.818483e-01	0.235
STAT5 Activation	R-HSA-9645135	5.826408e-01	0.235
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	5.826408e-01	0.235
Erythropoietin activates STAT5	R-HSA-9027283	5.826408e-01	0.235
Autointegration results in viral DNA circles	R-HSA-177539	5.826408e-01	0.235
Uncoating of the HIV Virion	R-HSA-162585	5.826408e-01	0.235
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	5.826408e-01	0.235
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	5.826408e-01	0.235
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	5.826408e-01	0.235
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	5.826408e-01	0.235
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.826408e-01	0.235
G2/M DNA replication checkpoint	R-HSA-69478	5.826408e-01	0.235
Integration of viral DNA into host genomic DNA	R-HSA-175567	5.826408e-01	0.235
HDL clearance	R-HSA-8964011	5.826408e-01	0.235
Neurofascin interactions	R-HSA-447043	5.826408e-01	0.235
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.826408e-01	0.235
Intrinsic Pathway for Apoptosis	R-HSA-109606	5.881187e-01	0.231
Selenoamino acid metabolism	R-HSA-2408522	5.957108e-01	0.225
RUNX2 regulates bone development	R-HSA-8941326	6.000002e-01	0.222
Signaling by Nuclear Receptors	R-HSA-9006931	6.000473e-01	0.222
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	6.003730e-01	0.222
Abacavir ADME	R-HSA-2161522	6.003730e-01	0.222
mRNA Splicing - Minor Pathway	R-HSA-72165	6.011407e-01	0.221
IRS-mediated signalling	R-HSA-112399	6.030063e-01	0.220
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.044457e-01	0.219
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	6.044457e-01	0.219
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77346	6.044457e-01	0.219
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	6.044457e-01	0.219
ER-Phagosome pathway	R-HSA-1236974	6.102380e-01	0.215
SARS-CoV-2-host interactions	R-HSA-9705683	6.150938e-01	0.211
Mitochondrial biogenesis	R-HSA-1592230	6.180590e-01	0.209
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.209934e-01	0.207
CD28 dependent PI3K/Akt signaling	R-HSA-389357	6.209934e-01	0.207
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.212686e-01	0.207
Recycling of eIF2:GDP	R-HSA-72731	6.212686e-01	0.207
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.212686e-01	0.207
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.212686e-01	0.207
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.212686e-01	0.207
Netrin mediated repulsion signals	R-HSA-418886	6.212686e-01	0.207
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.212686e-01	0.207
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.212686e-01	0.207
VLDL clearance	R-HSA-8964046	6.212686e-01	0.207
Activation of TRKA receptors	R-HSA-187015	6.212686e-01	0.207
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.212686e-01	0.207
CHL1 interactions	R-HSA-447041	6.212686e-01	0.207
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.212686e-01	0.207
Base Excision Repair	R-HSA-73884	6.221091e-01	0.206
Integration of energy metabolism	R-HSA-163685	6.232190e-01	0.205
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.295946e-01	0.201
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.295946e-01	0.201
Regulation of NPAS4 gene expression	R-HSA-9768759	6.295946e-01	0.201
Peroxisomal protein import	R-HSA-9033241	6.318794e-01	0.199
Transcriptional regulation by RUNX2	R-HSA-8878166	6.383855e-01	0.195
Phase 0 - rapid depolarisation	R-HSA-5576892	6.408757e-01	0.193
Inflammasomes	R-HSA-622312	6.408757e-01	0.193
Neddylation	R-HSA-8951664	6.425306e-01	0.192
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	6.521021e-01	0.186
RAS processing	R-HSA-9648002	6.521021e-01	0.186
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.534790e-01	0.185
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	6.534790e-01	0.185
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.534790e-01	0.185
PKA activation in glucagon signalling	R-HSA-164378	6.534790e-01	0.185
G beta:gamma signalling through PLC beta	R-HSA-418217	6.534790e-01	0.185
PKA activation	R-HSA-163615	6.534790e-01	0.185
Presynaptic function of Kainate receptors	R-HSA-500657	6.534790e-01	0.185
Tie2 Signaling	R-HSA-210993	6.534790e-01	0.185
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.534790e-01	0.185
Reverse Transcription of HIV RNA	R-HSA-162589	6.563234e-01	0.183
Minus-strand DNA synthesis	R-HSA-164516	6.563234e-01	0.183
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	6.563234e-01	0.183
phospho-PLA2 pathway	R-HSA-111995	6.563234e-01	0.183
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.563234e-01	0.183
MET receptor recycling	R-HSA-8875656	6.563234e-01	0.183
Signaling by MRAS-complex mutants	R-HSA-9660537	6.563234e-01	0.183
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	6.563234e-01	0.183
Interleukin-23 signaling	R-HSA-9020933	6.563234e-01	0.183
Co-stimulation by ICOS	R-HSA-9927354	6.563234e-01	0.183
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.563234e-01	0.183
Late SARS-CoV-2 Infection Events	R-HSA-9772573	6.565471e-01	0.183
PI Metabolism	R-HSA-1483255	6.567721e-01	0.183
Inositol phosphate metabolism	R-HSA-1483249	6.573299e-01	0.182
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.593920e-01	0.181
Aquaporin-mediated transport	R-HSA-445717	6.594849e-01	0.181
Glucagon-type ligand receptors	R-HSA-420092	6.600119e-01	0.180
Class I MHC mediated antigen processing & presentation	R-HSA-983169	6.619912e-01	0.179
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	6.684243e-01	0.175
Nuclear signaling by ERBB4	R-HSA-1251985	6.684243e-01	0.175
Ca2+ pathway	R-HSA-4086398	6.700844e-01	0.174
SARS-CoV Infections	R-HSA-9679506	6.727342e-01	0.172
Pre-NOTCH Processing in Golgi	R-HSA-1912420	6.761175e-01	0.170
PI-3K cascade:FGFR3	R-HSA-5654710	6.761175e-01	0.170
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	6.761175e-01	0.170
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.761175e-01	0.170
Maturation of nucleoprotein	R-HSA-9694631	6.761175e-01	0.170
SHC1 events in ERBB2 signaling	R-HSA-1250196	6.783991e-01	0.169
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	6.783991e-01	0.169
Interleukin-37 signaling	R-HSA-9008059	6.783991e-01	0.169
Transcriptional Regulation by VENTX	R-HSA-8853884	6.842126e-01	0.165
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.842126e-01	0.165
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	6.870023e-01	0.163
Lipophagy	R-HSA-9613354	6.881354e-01	0.162
MAPK1 (ERK2) activation	R-HSA-112411	6.881354e-01	0.162
MASTL Facilitates Mitotic Progression	R-HSA-2465910	6.881354e-01	0.162
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	6.881354e-01	0.162
Inactivation of CDC42 and RAC1	R-HSA-428543	6.881354e-01	0.162
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.881354e-01	0.162
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	6.881354e-01	0.162
Unwinding of DNA	R-HSA-176974	6.881354e-01	0.162
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	6.881354e-01	0.162
AKT phosphorylates targets in the nucleus	R-HSA-198693	6.881354e-01	0.162
Regulation of CDH11 gene transcription	R-HSA-9762293	6.881354e-01	0.162
Regulated proteolysis of p75NTR	R-HSA-193692	6.881354e-01	0.162
Interleukin-1 processing	R-HSA-448706	6.881354e-01	0.162
Defects in biotin (Btn) metabolism	R-HSA-3323169	6.881354e-01	0.162
Cargo concentration in the ER	R-HSA-5694530	6.960383e-01	0.157
PI-3K cascade:FGFR4	R-HSA-5654720	6.975359e-01	0.156
Formation of ATP by chemiosmotic coupling	R-HSA-163210	6.975359e-01	0.156
Co-inhibition by CTLA4	R-HSA-389513	6.975359e-01	0.156
VxPx cargo-targeting to cilium	R-HSA-5620916	6.975359e-01	0.156
Insulin receptor signalling cascade	R-HSA-74751	6.983930e-01	0.156
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.994640e-01	0.155
Platelet homeostasis	R-HSA-418346	7.075007e-01	0.150
Diseases of mitotic cell cycle	R-HSA-9675126	7.129346e-01	0.147
Signaling by WNT in cancer	R-HSA-4791275	7.129346e-01	0.147
DNA strand elongation	R-HSA-69190	7.129346e-01	0.147
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.129346e-01	0.147
Cytosolic tRNA aminoacylation	R-HSA-379716	7.141780e-01	0.146
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	7.169163e-01	0.145
Binding and entry of HIV virion	R-HSA-173107	7.170045e-01	0.144
MAPK3 (ERK1) activation	R-HSA-110056	7.170045e-01	0.144
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.170045e-01	0.144
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.170045e-01	0.144
EGFR Transactivation by Gastrin	R-HSA-2179392	7.170045e-01	0.144
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.170045e-01	0.144
Arachidonate production from DAG	R-HSA-426048	7.170045e-01	0.144
Interleukin-27 signaling	R-HSA-9020956	7.170045e-01	0.144
Regulation of CDH11 function	R-HSA-9762292	7.170045e-01	0.144
G-protein activation	R-HSA-202040	7.177662e-01	0.144
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	7.177662e-01	0.144
Lagging Strand Synthesis	R-HSA-69186	7.177662e-01	0.144
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.177662e-01	0.144
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.177662e-01	0.144
Ion channel transport	R-HSA-983712	7.186550e-01	0.143
Antigen processing-Cross presentation	R-HSA-1236975	7.264004e-01	0.139
Stimuli-sensing channels	R-HSA-2672351	7.264004e-01	0.139
G alpha (z) signalling events	R-HSA-418597	7.305685e-01	0.136
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.328862e-01	0.135
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.368448e-01	0.133
Amine ligand-binding receptors	R-HSA-375280	7.420013e-01	0.130
LGI-ADAM interactions	R-HSA-5682910	7.432027e-01	0.129
Interleukin-2 signaling	R-HSA-9020558	7.432027e-01	0.129
Regulation of localization of FOXO transcription factors	R-HSA-9614399	7.432027e-01	0.129
vRNP Assembly	R-HSA-192905	7.432027e-01	0.129
vRNA Synthesis	R-HSA-192814	7.432027e-01	0.129
Synthesis of PI	R-HSA-1483226	7.432027e-01	0.129
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.432027e-01	0.129
PECAM1 interactions	R-HSA-210990	7.432027e-01	0.129
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.432027e-01	0.129
Transport of RCbl within the body	R-HSA-9758890	7.432027e-01	0.129
Dissolution of Fibrin Clot	R-HSA-75205	7.432027e-01	0.129
Miscellaneous transport and binding events	R-HSA-5223345	7.445338e-01	0.128
Heme degradation	R-HSA-189483	7.445338e-01	0.128
PI-3K cascade:FGFR1	R-HSA-5654689	7.548114e-01	0.122
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.548114e-01	0.122
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.548114e-01	0.122
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.548114e-01	0.122
Signaling by KIT in disease	R-HSA-9669938	7.548114e-01	0.122
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	7.548114e-01	0.122
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.548114e-01	0.122
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.551190e-01	0.122
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	7.563422e-01	0.121
Extra-nuclear estrogen signaling	R-HSA-9009391	7.572814e-01	0.121
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	7.590385e-01	0.120
Signal amplification	R-HSA-392518	7.592612e-01	0.120
RA biosynthesis pathway	R-HSA-5365859	7.592612e-01	0.120
Anchoring fibril formation	R-HSA-2214320	7.669771e-01	0.115
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.669771e-01	0.115
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	7.669771e-01	0.115
PI3K events in ERBB4 signaling	R-HSA-1250342	7.669771e-01	0.115
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.669771e-01	0.115
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.669771e-01	0.115
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	7.669771e-01	0.115
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.669771e-01	0.115
ERKs are inactivated	R-HSA-202670	7.669771e-01	0.115
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.669771e-01	0.115
Activation of RAC1	R-HSA-428540	7.669771e-01	0.115
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.669771e-01	0.115
Signaling by Insulin receptor	R-HSA-74752	7.715271e-01	0.113
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.717084e-01	0.113
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	7.717084e-01	0.113
Carnitine shuttle	R-HSA-200425	7.717084e-01	0.113
Formation of the ureteric bud	R-HSA-9830674	7.717084e-01	0.113
ABC transporters in lipid homeostasis	R-HSA-1369062	7.717084e-01	0.113
PERK regulates gene expression	R-HSA-381042	7.732936e-01	0.112
Extension of Telomeres	R-HSA-180786	7.772682e-01	0.109
Cytoprotection by HMOX1	R-HSA-9707564	7.783246e-01	0.109
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.797997e-01	0.108
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.797997e-01	0.108
Lysosome Vesicle Biogenesis	R-HSA-432720	7.866483e-01	0.104
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.875799e-01	0.104
Thromboxane signalling through TP receptor	R-HSA-428930	7.875799e-01	0.104
TRAF6 mediated NF-kB activation	R-HSA-933542	7.875799e-01	0.104
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	7.875799e-01	0.104
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.875799e-01	0.104
Interleukin-6 family signaling	R-HSA-6783589	7.875799e-01	0.104
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.879159e-01	0.104
Maple Syrup Urine Disease	R-HSA-9865114	7.885517e-01	0.103
Scavenging by Class F Receptors	R-HSA-3000484	7.885517e-01	0.103
Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77285	7.885517e-01	0.103
Polymerase switching	R-HSA-69091	7.885517e-01	0.103
Leading Strand Synthesis	R-HSA-69109	7.885517e-01	0.103
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	7.885517e-01	0.103
SHC-related events triggered by IGF1R	R-HSA-2428933	7.885517e-01	0.103
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.885517e-01	0.103
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.885517e-01	0.103
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.885517e-01	0.103
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.885517e-01	0.103
Repression of WNT target genes	R-HSA-4641265	7.885517e-01	0.103
Regulation of IFNG signaling	R-HSA-877312	7.885517e-01	0.103
Diseases associated with surfactant metabolism	R-HSA-5687613	7.885517e-01	0.103
Interleukin-35 Signalling	R-HSA-8984722	7.885517e-01	0.103
OAS antiviral response	R-HSA-8983711	7.885517e-01	0.103
GPER1 signaling	R-HSA-9634597	7.913796e-01	0.102
Diseases of carbohydrate metabolism	R-HSA-5663084	7.964957e-01	0.099
Formation of paraxial mesoderm	R-HSA-9793380	7.981632e-01	0.098
Voltage gated Potassium channels	R-HSA-1296072	7.993439e-01	0.097
PI-3K cascade:FGFR2	R-HSA-5654695	8.024707e-01	0.096
G protein gated Potassium channels	R-HSA-1296059	8.024707e-01	0.096
Activation of G protein gated Potassium channels	R-HSA-1296041	8.024707e-01	0.096
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.024707e-01	0.096
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.024707e-01	0.096
Acyl chain remodelling of PS	R-HSA-1482801	8.024707e-01	0.096
Tight junction interactions	R-HSA-420029	8.024707e-01	0.096
Signaling by PDGF	R-HSA-186797	8.080165e-01	0.093
Adenylate cyclase activating pathway	R-HSA-170660	8.081299e-01	0.093
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.081299e-01	0.093
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.081299e-01	0.093
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	8.081299e-01	0.093
Formation of axial mesoderm	R-HSA-9796292	8.081299e-01	0.093
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.081299e-01	0.093
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	8.081299e-01	0.093
Interleukin-6 signaling	R-HSA-1059683	8.081299e-01	0.093
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	8.081299e-01	0.093
CD28 dependent Vav1 pathway	R-HSA-389359	8.081299e-01	0.093
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.081299e-01	0.093
Maturation of nucleoprotein	R-HSA-9683610	8.081299e-01	0.093
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.081299e-01	0.093
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.134157e-01	0.090
SARS-CoV-2 Infection	R-HSA-9694516	8.143631e-01	0.089
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.164264e-01	0.088
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.164264e-01	0.088
TRP channels	R-HSA-3295583	8.164264e-01	0.088
Urea cycle	R-HSA-70635	8.164264e-01	0.088
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	8.228374e-01	0.085
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.228374e-01	0.085
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	8.258965e-01	0.083
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.258965e-01	0.083
Removal of the Flap Intermediate	R-HSA-69166	8.258965e-01	0.083
CRMPs in Sema3A signaling	R-HSA-399956	8.258965e-01	0.083
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.258965e-01	0.083
Hydrolysis of LPC	R-HSA-1483115	8.258965e-01	0.083
Physiological factors	R-HSA-5578768	8.258965e-01	0.083
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.258965e-01	0.083
Regulation of KIT signaling	R-HSA-1433559	8.258965e-01	0.083
Ciprofloxacin ADME	R-HSA-9793528	8.258965e-01	0.083
HDL assembly	R-HSA-8963896	8.258965e-01	0.083
Zinc transporters	R-HSA-435354	8.258965e-01	0.083
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.258965e-01	0.083
Signaling by FGFR3 in disease	R-HSA-5655332	8.294925e-01	0.081
HIV Transcription Elongation	R-HSA-167169	8.336771e-01	0.079
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	8.336771e-01	0.079
Diseases of Immune System	R-HSA-5260271	8.336771e-01	0.079
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.336771e-01	0.079
Generation of second messenger molecules	R-HSA-202433	8.336771e-01	0.079
FOXO-mediated transcription	R-HSA-9614085	8.356028e-01	0.078
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.376264e-01	0.077
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.378178e-01	0.077
Telomere Extension By Telomerase	R-HSA-171319	8.417139e-01	0.075
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	8.417139e-01	0.075
HIV elongation arrest and recovery	R-HSA-167287	8.417139e-01	0.075
Formation of the Early Elongation Complex	R-HSA-113418	8.417139e-01	0.075
Pausing and recovery of HIV elongation	R-HSA-167290	8.417139e-01	0.075
Insulin receptor recycling	R-HSA-77387	8.417139e-01	0.075
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.417139e-01	0.075
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.417139e-01	0.075
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.417139e-01	0.075
Pyroptosis	R-HSA-5620971	8.417139e-01	0.075
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.420188e-01	0.075
Protein lipoylation	R-HSA-9857492	8.420188e-01	0.075
Telomere C-strand synthesis initiation	R-HSA-174430	8.420188e-01	0.075
Processive synthesis on the lagging strand	R-HSA-69183	8.420188e-01	0.075
DNA Damage Reversal	R-HSA-73942	8.420188e-01	0.075
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.420188e-01	0.075
Beta oxidation of butanoyl-CoA to acetyl-CoA	R-HSA-77352	8.420188e-01	0.075
IRF3-mediated induction of type I IFN	R-HSA-3270619	8.420188e-01	0.075
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	8.420188e-01	0.075
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	8.420188e-01	0.075
Protein localization	R-HSA-9609507	8.448812e-01	0.073
Post-translational protein modification	R-HSA-597592	8.510209e-01	0.070
mRNA Capping	R-HSA-72086	8.531351e-01	0.069
Downstream signaling of activated FGFR3	R-HSA-5654708	8.531351e-01	0.069
Regulation of CDH11 Expression and Function	R-HSA-9759475	8.531351e-01	0.069
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.536504e-01	0.069
Phosphorylation of the APC/C	R-HSA-176412	8.566491e-01	0.067
Defective GALNT3 causes HFTC	R-HSA-5083625	8.566491e-01	0.067
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.566491e-01	0.067
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.566491e-01	0.067
Induction of Cell-Cell Fusion	R-HSA-9733458	8.566491e-01	0.067
Fructose catabolism	R-HSA-70350	8.566491e-01	0.067
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.566491e-01	0.067
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	8.566491e-01	0.067
Attachment and Entry	R-HSA-9678110	8.566491e-01	0.067
Atorvastatin ADME	R-HSA-9754706	8.566491e-01	0.067
Transcription of the HIV genome	R-HSA-167172	8.593063e-01	0.066
Disorders of transmembrane transporters	R-HSA-5619115	8.598746e-01	0.066
FCERI mediated NF-kB activation	R-HSA-2871837	8.600142e-01	0.065
Activation of GABAB receptors	R-HSA-991365	8.628281e-01	0.064
GABA B receptor activation	R-HSA-977444	8.628281e-01	0.064
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	8.637994e-01	0.064
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.637994e-01	0.064
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.637994e-01	0.064
Downstream signaling of activated FGFR4	R-HSA-5654716	8.637994e-01	0.064
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.642635e-01	0.063
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.654053e-01	0.063
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	8.699253e-01	0.061
Glycine degradation	R-HSA-6783984	8.699253e-01	0.061
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	8.699253e-01	0.061
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	R-HSA-77288	8.699253e-01	0.061
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	8.699253e-01	0.061
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	8.699253e-01	0.061
Acetylcholine regulates insulin secretion	R-HSA-399997	8.699253e-01	0.061
TRAF3-dependent IRF activation pathway	R-HSA-918233	8.699253e-01	0.061
Passive transport by Aquaporins	R-HSA-432047	8.699253e-01	0.061
Fibronectin matrix formation	R-HSA-1566977	8.699253e-01	0.061
Galactose catabolism	R-HSA-70370	8.699253e-01	0.061
Coenzyme A biosynthesis	R-HSA-196783	8.699253e-01	0.061
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	8.699253e-01	0.061
COPII-mediated vesicle transport	R-HSA-204005	8.736329e-01	0.059
Fatty acyl-CoA biosynthesis	R-HSA-75105	8.736329e-01	0.059
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.737490e-01	0.059
Molecules associated with elastic fibres	R-HSA-2129379	8.737490e-01	0.059
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	8.765106e-01	0.057
Asparagine N-linked glycosylation	R-HSA-446203	8.789555e-01	0.056
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.819726e-01	0.055
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	8.819726e-01	0.055
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.819726e-01	0.055
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.819726e-01	0.055
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	8.819726e-01	0.055
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.819726e-01	0.055
Choline catabolism	R-HSA-6798163	8.819726e-01	0.055
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.819726e-01	0.055
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.820315e-01	0.055
Inwardly rectifying K+ channels	R-HSA-1296065	8.830248e-01	0.054
Somitogenesis	R-HSA-9824272	8.873884e-01	0.052
Rab regulation of trafficking	R-HSA-9007101	8.874665e-01	0.052
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.916662e-01	0.050
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	8.916662e-01	0.050
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	8.916662e-01	0.050
Cardiogenesis	R-HSA-9733709	8.916662e-01	0.050
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	8.929048e-01	0.049
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	8.929048e-01	0.049
Synaptic adhesion-like molecules	R-HSA-8849932	8.929048e-01	0.049
Mismatch Repair	R-HSA-5358508	8.929048e-01	0.049
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	8.929048e-01	0.049
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.946562e-01	0.048
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.946562e-01	0.048
Signaling by TGFBR3	R-HSA-9839373	8.946562e-01	0.048
Negative regulation of the PI3K/AKT network	R-HSA-199418	8.951175e-01	0.048
tRNA Aminoacylation	R-HSA-379724	8.953618e-01	0.048
Acyl chain remodelling of PC	R-HSA-1482788	8.997110e-01	0.046
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.997110e-01	0.046
Gene expression (Transcription)	R-HSA-74160	9.008898e-01	0.045
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	9.028250e-01	0.044
Signaling by FGFR2 IIIa TM	R-HSA-8851708	9.028250e-01	0.044
Germ layer formation at gastrulation	R-HSA-9754189	9.028250e-01	0.044
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.028250e-01	0.044
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.028250e-01	0.044
Other interleukin signaling	R-HSA-449836	9.028250e-01	0.044
STING mediated induction of host immune responses	R-HSA-1834941	9.028250e-01	0.044
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.028250e-01	0.044
Regulation of insulin secretion	R-HSA-422356	9.031581e-01	0.044
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.071957e-01	0.042
Hyaluronan metabolism	R-HSA-2142845	9.071957e-01	0.042
Mitochondrial protein import	R-HSA-1268020	9.073493e-01	0.042
PPARA activates gene expression	R-HSA-1989781	9.088473e-01	0.042
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	9.118268e-01	0.040
Creatine metabolism	R-HSA-71288	9.118268e-01	0.040
Acyl chain remodelling of PI	R-HSA-1482922	9.118268e-01	0.040
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.118268e-01	0.040
Signaling by NODAL	R-HSA-1181150	9.118268e-01	0.040
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.140105e-01	0.039
Acyl chain remodelling of PE	R-HSA-1482839	9.141550e-01	0.039
Downstream signaling of activated FGFR2	R-HSA-5654696	9.141550e-01	0.039
Downstream signaling of activated FGFR1	R-HSA-5654687	9.141550e-01	0.039
Transferrin endocytosis and recycling	R-HSA-917977	9.141550e-01	0.039
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.159949e-01	0.038
Azathioprine ADME	R-HSA-9748787	9.196856e-01	0.036
Signaling by FGFR2 in disease	R-HSA-5655253	9.196856e-01	0.036
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.199952e-01	0.036
Abacavir metabolism	R-HSA-2161541	9.199952e-01	0.036
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.199952e-01	0.036
Basigin interactions	R-HSA-210991	9.199952e-01	0.036
Acyl chain remodelling of PG	R-HSA-1482925	9.199952e-01	0.036
GPVI-mediated activation cascade	R-HSA-114604	9.206219e-01	0.036
tRNA processing	R-HSA-72306	9.215248e-01	0.035
TRAF6 mediated IRF7 activation	R-HSA-933541	9.266278e-01	0.033
Metabolism of folate and pterines	R-HSA-196757	9.266278e-01	0.033
Collagen chain trimerization	R-HSA-8948216	9.266278e-01	0.033
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.274073e-01	0.033
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	9.274073e-01	0.033
Serine metabolism	R-HSA-977347	9.274073e-01	0.033
Androgen biosynthesis	R-HSA-193048	9.274073e-01	0.033
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.274073e-01	0.033
Attachment and Entry	R-HSA-9694614	9.274073e-01	0.033
Ribavirin ADME	R-HSA-9755088	9.274073e-01	0.033
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.277234e-01	0.033
Elastic fibre formation	R-HSA-1566948	9.322028e-01	0.030
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.322028e-01	0.030
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.341332e-01	0.030
Fructose metabolism	R-HSA-5652084	9.341332e-01	0.030
Amino acids regulate mTORC1	R-HSA-9639288	9.347531e-01	0.029
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.373750e-01	0.028
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.402362e-01	0.027
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.402362e-01	0.027
Termination of O-glycan biosynthesis	R-HSA-977068	9.402362e-01	0.027
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.402362e-01	0.027
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.402362e-01	0.027
RNA Polymerase II Transcription	R-HSA-73857	9.419307e-01	0.026
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.421713e-01	0.026
Paracetamol ADME	R-HSA-9753281	9.433002e-01	0.025
SLC transporter disorders	R-HSA-5619102	9.450360e-01	0.025
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.457740e-01	0.024
Complex III assembly	R-HSA-9865881	9.457740e-01	0.024
TNFs bind their physiological receptors	R-HSA-5669034	9.457740e-01	0.024
Plasma lipoprotein assembly	R-HSA-8963898	9.457740e-01	0.024
Cardiac conduction	R-HSA-5576891	9.464278e-01	0.024
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.466168e-01	0.024
Maturation of spike protein	R-HSA-9694548	9.466168e-01	0.024
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.471728e-01	0.024
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.507353e-01	0.022
HIV Transcription Initiation	R-HSA-167161	9.507353e-01	0.022
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.507353e-01	0.022
Scavenging by Class A Receptors	R-HSA-3000480	9.507353e-01	0.022
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.507991e-01	0.022
Hyaluronan degradation	R-HSA-2160916	9.507991e-01	0.022
Laminin interactions	R-HSA-3000157	9.507991e-01	0.022
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.507991e-01	0.022
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.507991e-01	0.022
Immune System	R-HSA-168256	9.511547e-01	0.022
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.541900e-01	0.020
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	9.545493e-01	0.020
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.553587e-01	0.020
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.553587e-01	0.020
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.553587e-01	0.020
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.553587e-01	0.020
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.553587e-01	0.020
Formation of the cornified envelope	R-HSA-6809371	9.567549e-01	0.019
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.573623e-01	0.019
RNA Polymerase II Promoter Escape	R-HSA-73776	9.580798e-01	0.019
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	9.594960e-01	0.018
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	9.594960e-01	0.018
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.594960e-01	0.018
Signaling by BMP	R-HSA-201451	9.594960e-01	0.018
Triglyceride biosynthesis	R-HSA-75109	9.594960e-01	0.018
Synthesis of PE	R-HSA-1483213	9.594960e-01	0.018
Insulin processing	R-HSA-264876	9.594960e-01	0.018
GABA receptor activation	R-HSA-977443	9.603277e-01	0.018
Signaling by Retinoic Acid	R-HSA-5362517	9.603277e-01	0.018
Metabolism of polyamines	R-HSA-351202	9.603277e-01	0.018
Surfactant metabolism	R-HSA-5683826	9.613466e-01	0.017
Neurotransmitter release cycle	R-HSA-112310	9.628360e-01	0.016
Collagen degradation	R-HSA-1442490	9.630985e-01	0.016
Prednisone ADME	R-HSA-9757110	9.632501e-01	0.016
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.643682e-01	0.016
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	9.643682e-01	0.016
Integrin cell surface interactions	R-HSA-216083	9.668788e-01	0.015
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.671620e-01	0.015
Parasite infection	R-HSA-9664407	9.675588e-01	0.014
Leishmania phagocytosis	R-HSA-9664417	9.675588e-01	0.014
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.675588e-01	0.014
Synthesis of PC	R-HSA-1483191	9.697442e-01	0.013
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.697472e-01	0.013
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.697472e-01	0.013
Neurotransmitter clearance	R-HSA-112311	9.697472e-01	0.013
DAP12 signaling	R-HSA-2424491	9.697472e-01	0.013
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.725517e-01	0.012
Mitochondrial protein degradation	R-HSA-9837999	9.728366e-01	0.012
Infectious disease	R-HSA-5663205	9.758485e-01	0.011
Potassium Channels	R-HSA-1296071	9.775717e-01	0.010
The phototransduction cascade	R-HSA-2514856	9.782470e-01	0.010
Developmental Cell Lineages	R-HSA-9734767	9.783766e-01	0.009
Metabolism of proteins	R-HSA-392499	9.788535e-01	0.009
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.795001e-01	0.009
Glutamate and glutamine metabolism	R-HSA-8964539	9.795001e-01	0.009
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.795001e-01	0.009
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.808025e-01	0.008
Gastrulation	R-HSA-9758941	9.808538e-01	0.008
eNOS activation	R-HSA-203615	9.814009e-01	0.008
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.814009e-01	0.008
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.814009e-01	0.008
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.814009e-01	0.008
Nucleotide biosynthesis	R-HSA-8956320	9.815793e-01	0.008
Metabolism of porphyrins	R-HSA-189445	9.823917e-01	0.008
Metabolism of cofactors	R-HSA-8978934	9.823917e-01	0.008
Parasitic Infection Pathways	R-HSA-9824443	9.826651e-01	0.008
Leishmania infection	R-HSA-9658195	9.826651e-01	0.008
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.831256e-01	0.007
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.836712e-01	0.007
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.846904e-01	0.007
FGFR2 mutant receptor activation	R-HSA-1839126	9.846904e-01	0.007
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.847321e-01	0.007
Interferon alpha/beta signaling	R-HSA-909733	9.856566e-01	0.006
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.861102e-01	0.006
SLC-mediated transport of organic cations	R-HSA-549127	9.861102e-01	0.006
Lysine catabolism	R-HSA-71064	9.861102e-01	0.006
Class B/2 (Secretin family receptors)	R-HSA-373080	9.864668e-01	0.006
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.873984e-01	0.006
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.873984e-01	0.006
G alpha (q) signalling events	R-HSA-416476	9.881808e-01	0.005
Pentose phosphate pathway	R-HSA-71336	9.885672e-01	0.005
Generic Transcription Pathway	R-HSA-212436	9.886983e-01	0.005
Regulation of beta-cell development	R-HSA-186712	9.888668e-01	0.005
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.896277e-01	0.005
Interleukin-10 signaling	R-HSA-6783783	9.896666e-01	0.005
RAB geranylgeranylation	R-HSA-8873719	9.897695e-01	0.004
Disease	R-HSA-1643685	9.897894e-01	0.004
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.898137e-01	0.004
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.901889e-01	0.004
Collagen formation	R-HSA-1474290	9.905176e-01	0.004
NCAM signaling for neurite out-growth	R-HSA-375165	9.913655e-01	0.004
Intra-Golgi traffic	R-HSA-6811438	9.914628e-01	0.004
Heme biosynthesis	R-HSA-189451	9.914628e-01	0.004
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.929734e-01	0.003
Pyrimidine catabolism	R-HSA-73621	9.929734e-01	0.003
DAP12 interactions	R-HSA-2172127	9.936253e-01	0.003
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.936253e-01	0.003
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.936253e-01	0.003
Synthesis of bile acids and bile salts	R-HSA-192105	9.938574e-01	0.003
Nicotinate metabolism	R-HSA-196807	9.943652e-01	0.002
Kidney development	R-HSA-9830369	9.943652e-01	0.002
G alpha (s) signalling events	R-HSA-418555	9.947721e-01	0.002
O-linked glycosylation of mucins	R-HSA-913709	9.948285e-01	0.002
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.948285e-01	0.002
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.948715e-01	0.002
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.952404e-01	0.002
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.960055e-01	0.002
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.960828e-01	0.002
Purine catabolism	R-HSA-74259	9.963359e-01	0.002
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.964464e-01	0.002
Extracellular matrix organization	R-HSA-1474244	9.966464e-01	0.001
Branched-chain amino acid catabolism	R-HSA-70895	9.967763e-01	0.001
Complex IV assembly	R-HSA-9864848	9.967763e-01	0.001
Citric acid cycle (TCA cycle)	R-HSA-71403	9.971743e-01	0.001
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.972251e-01	0.001
Bile acid and bile salt metabolism	R-HSA-194068	9.974769e-01	0.001
Transport of small molecules	R-HSA-382551	9.974972e-01	0.001
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.976854e-01	0.001
Cholesterol biosynthesis	R-HSA-191273	9.978232e-01	0.001
Innate Immune System	R-HSA-168249	9.980314e-01	0.001
Synthesis of PA	R-HSA-1483166	9.982034e-01	0.001
Dectin-2 family	R-HSA-5621480	9.982034e-01	0.001
Interferon gamma signaling	R-HSA-877300	9.982484e-01	0.001
Sialic acid metabolism	R-HSA-4085001	9.985216e-01	0.001
Triglyceride metabolism	R-HSA-8979227	9.985216e-01	0.001
Amino acid transport across the plasma membrane	R-HSA-352230	9.985216e-01	0.001
Degradation of the extracellular matrix	R-HSA-1474228	9.986707e-01	0.001
Phospholipid metabolism	R-HSA-1483257	9.986791e-01	0.001
Metabolism of steroids	R-HSA-8957322	9.987516e-01	0.001
G alpha (i) signalling events	R-HSA-418594	9.988873e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.989989e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.990919e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.993222e-01	0.000
SLC-mediated transport of amino acids	R-HSA-9958863	9.993222e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.993222e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.994942e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.995085e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.995412e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.995909e-01	0.000
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.996576e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.996576e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.996584e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.996765e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.997637e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.997654e-01	0.000
Nuclear Receptor transcription pathway	R-HSA-383280	9.997682e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.997682e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.997898e-01	0.000
Keratinization	R-HSA-6805567	9.998085e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.998102e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.998102e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.998710e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.998820e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.998851e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999208e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999505e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999527e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999606e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999702e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999755e-01	0.000
Drug ADME	R-HSA-9748784	9.999764e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999768e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999801e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999850e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999876e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999879e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999884e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999902e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999908e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999908e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999924e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999938e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999939e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.999943e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999952e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999962e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999982e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999984e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999984e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999993e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999997e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999997e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999997e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999998e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999998e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999998e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999999e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000