PRKD1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A6ND36 S356 SIGNOR|PSP FAM83G PAWS1 PAGTVAKKLVNPKYALVKAKsVDEIAKIssEKQEAKKPLGL
O00206 S790 EPSD|PSP TLR4 VLQKVEKTLLRQQVELYRLLsRNTYLEWEDSVLGRHIFWRR
O00429 S637 EPSD|PSP DNM1L DLP1 DRP1 PQKGHAVNLLDVPVPVARKLsAREQRDCEVIERLIKSYFLI
O00488 S93 Sugiyama ZNF593 ZT86 STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O14558 S16 EPSD|PSP HSPB6 _____MEIPVPVQPSWLRRAsAPLPGLSAPGRLFDQRFGEG
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15143 S310 Sugiyama ARPC1B ARC41 QSSQRGLTARERFQNLDKKAssEGGtAAGAGLDsLHKNsVs
O15273 S157 EPSD|PSP TCAP TKQLPPVVPVSKPGALRRSLsRSMsQEAQRG__________
O15273 S161 EPSD|PSP TCAP PPVVPVSKPGALRRSLsRSMsQEAQRG______________
O15355 T528 Sugiyama PPM1G PPM1C RNTAELQPEsGKRKLEEVLstEGAEENGNsDKKKKAKRD__
O15460 T532 Sugiyama P4HA2 UNQ290/PRO330 WVSNKWFHERGQEFLRPCGstEVD_________________
O43815 S229 Sugiyama STRN TEAEVKETAMIAKSELtDsAsVLDNFKFLEsAAADFsDEDE
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60331 S448 PSP PIP5K1C KIAA0589 PSFYAERFFKFMSNTVFRKNsSLKSsPSKKGRGGALLAVKP
O60343 S486 Sugiyama TBC1D4 AS160 KIAA0603 ERIEGLYPPRAKLVIQRHLssLtDNEQADIFERVQKMKPVS
O60602 S805 GPS6|SIGNOR|EPSD|PSP TLR5 TIL3 SALIMVVVGSLSQyQLMKHQsIRGFVQKQQYLRWPEDLQDV
O60664 S148 Sugiyama PLIN3 M6PRBP1 TIP47 KVsGAQEMVssAKDTVAtQLsEAVDATRGAVQSGVDKTKsV
O60664 S175 Sugiyama PLIN3 M6PRBP1 TIP47 RGAVQSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGK
O60749 S365 Sugiyama SNX2 TRG9 AKSAAMLGNsEDHTALSRALsQLAEVEEKIDQLHQEQAFAD
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75340 S120 Sugiyama PDCD6 ALG2 RTYDRDNsGMIDKNELKQALsGFGYRLSDQFHDILIRKFDR
O75369 S2532 Sugiyama FLNB FLN1L FLN3 TABP TAP ASKVTSKGAGLSKAFVGQKssFLVDCSKAGSNMLLIGVHGP
O75534 S584 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR YSLSKGKGNKVSAEKVNKtHsVNGItEEADPTIysGKVIRP
O75628 S18 SIGNOR|EPSD|PSP REM1 GES REM ___MTLNTEQEAKTPLHRRAsTPLPLSPRGHQPGRLSTVPS
O76021 S314 Sugiyama RSL1D1 CATX11 CSIG PBK1 L12 RNFEKQKERKKKRQQARKtAsVLsKDDVAPEsGDtTVKKPE
O94806 S391 Sugiyama PRKD3 EPK2 PRKCN FFLDPsDLDVERDEEAVKtIsPstsNNIPLMRVVQSIKHTK
O94806 S395 Sugiyama PRKD3 EPK2 PRKCN PsDLDVERDEEAVKtIsPstsNNIPLMRVVQSIKHTKRKSS
O94806 S735 Sugiyama PRKD3 EPK2 PRKCN QVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRSKGYNR
O94806 T739 Sugiyama PRKD3 EPK2 PRKCN CDFGFARIIGEKsFRRsVVGtPAyLAPEVLRSKGYNRSLDM
O94806 Y742 Sugiyama PRKD3 EPK2 PRKCN GFARIIGEKsFRRsVVGtPAyLAPEVLRSKGYNRSLDMWSV
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95251 T331 SIGNOR|PSP KAT7 HBO1 HBOa MYST2 RRAQARASEDLEKLRLQGQItEGSNMIKTIAFGRYELDTWY
O95251 T97 SIGNOR|PSP KAT7 HBO1 HBOa MYST2 VTRsQQQPtPVtPKKYPLRQtRssGsEtEQVVDFsDRETKN
O95292 S158 Sugiyama VAPB UNQ484/PRO983 NKIIstTAsKtEtPIVSKsLsssLDDtEVKKVMEECKRLQG
O95863 S11 SIGNOR|EPSD|PSP SNAI1 SNAH __________MPRSFLVRKPsDPNRKPNYSELQDSNPEFTF
O96013 S181 PSP PAK4 KIAA1142 KSSREGsGGPQESSRDKRPLsGPDVGtPQPAGLAsGAKLAA
O96013 S474 SIGNOR|PSP PAK4 KIAA1142 VKLSDFGFCAQVSKEVPRRKsLVGtPYWMAPELISRLPYGP
O96013 S99 EPSD|PSP PAK4 KIAA1142 DGALTLLLDEFENMSVTRsNsLRRDsPPPPARARQENGMPE
P00533 T678 GPS6 EGFR ERBB ERBB1 HER1 LVVALGIGLFMRRRHIVRKRtLRRLLQERELVEPLtPsGEA
P00533 T693 GPS6 EGFR ERBB ERBB1 HER1 IVRKRtLRRLLQERELVEPLtPsGEAPNQALLRILKETEFK
P00558 S175 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P04075 S354 Sugiyama ALDOA ALDA ANsLACQGKytPsGQAGAAAsEsLFVsNHAy__________
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S78 Sugiyama HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 GPS6|ELM|EPSD|PSP|Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S83 Sugiyama HSPB1 HSP27 HSP28 IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P05412 S63 EPSD|PSP JUN ADPVGSLKPHLRAKNsDLLtsPDVGLLKLAsPELERLIIQS
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05549 S258 EPSD|PSP TFAP2A AP2TF TFAP2 LsPPECLNASLLGGVLRRAKsKNGGRSLREKLDKIGLNLPA
P05549 S326 EPSD|PSP TFAP2A AP2TF TFAP2 YVCETEFPAKAVAEFLNRQHsDPNEQVTRKNMLLATKQICK
P05997 S1277 Sugiyama COL5A2 APDDKNKTDPGVHATLKSLSsQIETMRSPDGSKKHPARTCD
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07237 S427 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900 Y313 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P07900 Y61 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA KEIFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLI
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238 Y56 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEIFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDII
P08758 T10 Sugiyama ANXA5 ANX5 ENX2 PP4 ___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0CG47 S57 Sugiyama UBB PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48 S57 Sugiyama UBC PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412 S89 Sugiyama H1-4 H1F4 HIST1H1E AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P10412 T92 Sugiyama H1-4 H1F4 HIST1H1E DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11532 S3623 Sugiyama DMD EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P12004 S172 Sugiyama PCNA sHIGDAVVIsCAKDGVKFSAsGELGNGNIKLSQTSNVDKEE
P12277 S164 Sugiyama CKB CKBB PHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAEQ
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13674 T140 Sugiyama P4HA1 P4HA YFPNDEDQVGAAKALLRLQDtyNLDTDtIsKGNLPGVKHKS
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15374 S128 Sugiyama UCHL3 KDKMHFESGSTLKKFLEEsVsMsPEERARyLENyDAIRVtH
P15880 S249 Sugiyama RPS2 RPS4 CtAtLGNFAKATFDAISKTysyLtPDLWKEtVFtKsPyQEF
P15880 T285 Sugiyama RPS2 RPS4 PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P16220 S119 PSP CREB1 EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16401 S92 Sugiyama H1-5 H1F5 HIST1H1B GGYDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16401 T95 Sugiyama H1-5 H1F5 HIST1H1B DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402 S90 Sugiyama H1-3 H1F3 HIST1H1D AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16402 T93 Sugiyama H1-3 H1F3 HIST1H1D DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16403 S36 Sugiyama H1-2 H1F2 HIST1H1C EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S89 Sugiyama H1-2 H1F2 HIST1H1C AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16403 T92 Sugiyama H1-2 H1F2 HIST1H1C DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19174 S1248 SIGNOR|iPTMNet PLCG1 PLC1 LRERGsDASGQLFHGRAREGsFEsRyQQPFEDFRIsQEHLA
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19429 S23 GPS6 TNNI3 TNNC1 DGSSDAAREPRPAPAPIRRRssNyRAYAtEPHAKKKsKIsA
P19429 S24 GPS6 TNNI3 TNNC1 GSSDAAREPRPAPAPIRRRssNyRAYAtEPHAKKKsKIsAs
P22059 S240 SIGNOR|EPSD|PSP OSBP OSBP1 DLSTCNDLIAKHGTALQRsLsELEsLKLPAESNEKIKQVNE
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S225 Sugiyama HNRNPA2B1 HNRPA2B1 GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P23528 S3 SIGNOR|EPSD|PSP CFL1 CFL __________________MAsGVAVsDGVIKVFNDMKVRKs
P23528 S41 Sugiyama CFL1 CFL RKsstPEEVKKRKKAVLFCLsEDKKNIILEEGKEILVGDVG
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25205 S447 Sugiyama MCM3 EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25705 S198 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM GIIPRIsVREPMQTGIKAVDsLVPIGRGQRELIIGDRQTGK
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 S97 Sugiyama RPL13 BBC1 OK/SW-cl.46 sLEELRVAGIHKKVARTIGIsVDPRRRNKstEsLQANVQRL
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26599 S131 Sugiyama PTBP1 PTB VNYYTSVTPVLRGQPIyIQFsNHKELKtDSSPNQARAQAAL
P26641 S25 Sugiyama EEF1G EF1G PRO1608 TLyTyPENWRAFKALIAAQYsGAQVRVLsAPPHFHFGQtNR
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27348 S63 Sugiyama YWHAQ LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27986 S154 SIGNOR|PSP PIK3R1 GRB1 KLVEAIEKKGLECSTLyRtQssSNLAELRQLLDCDTPSVDL
P29401 S305 Sugiyama TKT LAtPPQEDAPsVDIANIRMPsLPsyKVGDKIATRKAYGQAL
P29692 S86 Sugiyama EEF1D EF1D GPGAssGtsGDHGELVVRIAsLEVENQsLRGVVQELQQAIs
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30559 S261 PSP OXTR AEAPEGAAAGDGGRVALARVsSVKLISKAKIRTVKMTFIIV
P31749 S473 EPSD|PSP AKT1 PKB RAC DQDDSMECVDSERRPHFPQFsysAsGtA_____________
P31749 T308 EPSD|PSP AKT1 PKB RAC IKITDFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGR
P31943 S269 Sugiyama HNRNPH1 HNRPH HNRPH1 YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQsttGH
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31946 S65 Sugiyama YWHAB LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P33176 S950 Sugiyama KIF5B KNS KNS1 PAAsPtHPSAIRGGGAFVQNsQPVAVRGGGGKQV_______
P33527 S915 Sugiyama ABCC1 MRP MRP1 QMENGMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQ
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932 S363 Sugiyama HSPA4 APG2 HSPH2 GATRIPAVKEKISKFFGKELsttLNADEAVTRGCALQCAIL
P35222 T112 SIGNOR|EPSD|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 QRVRAAMFPEtLDEGMQIPStQFDAAHPtNVQRLAEPSQML
P35222 T120 SIGNOR|EPSD|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 PEtLDEGMQIPStQFDAAHPtNVQRLAEPSQMLKHAVVNLI
P35236 S246 SIGNOR PTPN7 KECPEYTVRQLTIQYQEERRsVKHILFSAWPDHQTPESAGP
P35241 S532 Sugiyama RDX EERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHA
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35670 S1121 SIGNOR|PSP ATP7B PWD WC1 WND GIGCKVSNVEGILAHSERPLsAPASHLNEAGSLPAEKDAVP
P35670 S1453 SIGNOR|PSP ATP7B PWD WC1 WND LTSDKPSRHSAAADDDGDKWsLLLNGRDEEQYI________
P35670 S478 SIGNOR|PSP ATP7B PWD WC1 WND EVAPHTGRLPANHAPDILAKsPQsTRAVAPQKCFLQIKGMT
P35670 S481 SIGNOR|PSP ATP7B PWD WC1 WND PHTGRLPANHAPDILAKsPQsTRAVAPQKCFLQIKGMTCAS
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40227 S49 Sugiyama CCT6A CCT6 CCTZ GLQDVLRTNLGPKGTMKMLVsGAGDIKLTKDGNVLLHEMQI
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P42766 T59 Sugiyama RPL35 GAASKLsKIRVVRKSIARVLtVINQtQKENLRKFYKGKKyK
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490 S472 Sugiyama NAMPT PBEF PBEF1 EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46013 S1689 Sugiyama MKI67 DGKSMKAFMEsPKQILDsAAsLtGsKRQLRTPKGKsEVPED
P46060 S454 Sugiyama RANGAP1 KIAA1835 SD VstFLAFPsPEKLLRLGPKssVLIAQQTDTSDPEKVVSAFL
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46778 T29 Sugiyama RPL21 RGTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQ
P46779 S115 Sugiyama RPL28 HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P47712 S731 Sugiyama PLA2G4A CPLA2 PLA2G4 AMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA__
P48426 T376 SIGNOR|EPSD|PSP PIP4K2A PI5P4KA PIP5K2 PIP5K2A AIIDILTHYDAKKKAAHAAKtVKHGAGAEISTVNPEQYSKR
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49588 S775 Sugiyama AARS1 AARS VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P50552 S157 EPSD|PSP VASP EVEQQKRQQPGPSEHIERRVsNAGGPPAPPAGGPPPPPGPP
P50552 S322 EPSD|PSP VASP QSEsVRRPWEKNstTLPRMKssssVttsEtQPCtPsSSDyS
P53367 S132 SIGNOR|EPSD|PSP ARFIP1 ILADEIKNPAMEKLELVRKWsLNTYKCTRQIISEKLGRGSR
P53396 S478 Sugiyama ACLY EsRADEVAPAKKAKPAMPQDsVPsPRSLQGKSTTLFSRHTK
P53999 S10 Sugiyama SUB1 PC4 RPO2TC1 ___________MPKSKELVsssssGsDsDsEVDKKLKRKKQ
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55010 S10 Sugiyama EIF5 ___________MSVNVNRsVsDQFyRyKMPRLIAKVEGKGN
P55795 S269 Sugiyama HNRNPH2 FTP3 HNRPH2 YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQstTGH
P57772 S28 Sugiyama EEFSEC SELB VNVGVLGHIDSGKTALARALsTTASTAAFDKQPQSRERGIT
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60468 S49 Sugiyama SEC61B STVRQRKNASCGTRSAGRtTsAGTGGMWRFYTEDSPGLKVG
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60900 S175 Sugiyama PSMA6 PROS27 DPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTV
P61221 S591 Sugiyama ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 NNYRPRINKLNsIKDVEQKKsGNyFFLDD____________
P61247 S237 Sugiyama RPS3A FTE1 MFTL MLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyE
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61313 S97 Sugiyama RPL15 EC45 TCBAP0781 KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981 S64 Sugiyama YWHAG LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62750 Y144 Sugiyama RPL23A VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S138 Sugiyama RPL8 EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P62979 S57 Sugiyama RPS27A UBA80 UBCEP1 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987 S57 Sugiyama UBA52 UBCEP2 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63010 S258 PSP AP2B1 ADTB2 CLAPB1 QSICERVTPRLSHANSAVVLsAVKVLMKFLELLPKDSDyyN
P63010 Y277 PSP AP2B1 ADTB2 CLAPB1 LsAVKVLMKFLELLPKDSDyyNMLLKKLAPPLVTLLSGEPE
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63151 S113 Sugiyama PPP2R2A EEKINKIRWLPQKNAAQFLLsTNDKTIKLWKISERDKRPEG
P63165 S31 Sugiyama SUMO1 SMT3C SMT3H3 UBL1 OK/SW-cl.43 EDLGDKKEGEYIKLKVIGQDssEIHFKVKMTTHLKKLKESY
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68104 T261 Sugiyama EEF1A1 EEF1A EF1A LENG7 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P78345 S253 Sugiyama RPP38 DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q02539 S92 Sugiyama H1-1 H1F1 HIST1H1A AGyDVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNK
Q02539 T95 Sugiyama H1-1 H1F1 HIST1H1A DVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNKKAS
Q04206 S131 Sugiyama RELA NFKB3 HSFQNLGIQCVKKRDLEQAIsQRIQtNNNPFQVPIEEQRGD
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q04917 S64 Sugiyama YWHAH YWHA1 LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA
Q05397 S677 Sugiyama PTK2 FAK FAK1 KCWAYDPSRRPRFTELKAQLsTILEEEKAQQEERMRMEsRR
Q05639 T261 Sugiyama EEF1A2 EEF1AL STN PTDKPLRLPLQDVyKIGGIGtVPVGRVETGILRPGMVVTFA
Q06124 S140 Sugiyama PTPN11 PTP2C SHPTP2 KEAEKLLTEKGKHGsFLVREsQsHPGDFVLSVRTGDDKGES
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q12809 S284 SIGNOR KCNH2 ERG ERG1 HERG SCSLARTRSRESCASVRRAssADDIEAMRAGVLPPPPRHAS
Q13563 S801 SIGNOR PKD2 TRPP1 TRPP2 DLEKEREDLDLDHssLPRPMssRSFPRSLDDsEEDDDEDSG
Q13573 S182 Sugiyama SNW1 SKIIP SKIP AMPVRAADKLAPAQyIRytPsQQGVAFNsGAKQRVIRMVEM
Q13596 S229 Sugiyama SNX1 PPPPEKSLIGMTKVKVGKEDsssAEFLEKRRAALERYLQRI
Q13596 S368 Sugiyama SNX1 AKSLAMLGSSEDNTALSRALsQLAEVEEKIEQLHQEQANND
Q13671 S292 GPS6|SIGNOR|EPSD|PSP RIN1 GAVPSQTERLPPCQLLRREssVGYRVPAGSGPSLPPMPSLQ
Q13671 S351 GPS6|SIGNOR|ELM|EPSD|PSP RIN1 RGsPAtsPHLGRRRPLLRsMsAAFCsLLAPERQVGRAAAAL
Q13936 S1981 SIGNOR|EPSD|PSP CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1 DIRQSPKRGFLRSASLGRRAsFHLECLKRQKDRGGDISQKT
Q14126 S551 Sugiyama DSG2 CDHF5 FSVIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFL
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14247 S298 GPS6|SIGNOR|EPSD|PSP CTTN EMS1 ERQDsAAVGFDyKEKLAKHEsQQDySKGFGGKyGVQKDRMD
Q14247 S348 GPS6|SIGNOR|EPSD|PSP CTTN EMS1 tQVssAyQKTVPVEAVtsKtsNIRANFENLAKEKEQEDRRK
Q14257 S37 Sugiyama RCN2 ERC55 AAAAGAGKAEELHyPLGERRsDyDREALLGVQEDVDEyVKL
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14896 S304 EPSD|PSP MYBPC3 sDSHEDTGILDFSSLLKKRDsFRTPRDsKLEAPAEEDVWEI
Q15021 S1333 Sugiyama NCAPD2 CAPD2 CNAP1 KIAA0159 APsAKKPSTGSRyQPLAstAsDNDFVtPEPRRTTRRHPNTQ
Q15139 S205 GPS6|SIGNOR|ELM|iPTMNet PRKD1 PKD PKD1 PRKCM HKRCAFKIPNNCSGVRRRRLsNVsLtGVSTIRtssAELsTs
Q15139 S223 Sugiyama PRKD1 PKD PKD1 PRKCM RLsNVsLtGVSTIRtssAELsTsAPDEPLLQKsPsEsFIGR
Q15139 S225 Sugiyama PRKD1 PKD PKD1 PRKCM sNVsLtGVSTIRtssAELsTsAPDEPLLQKsPsEsFIGREK
Q15139 S237 Sugiyama PRKD1 PKD PKD1 PRKCM tssAELsTsAPDEPLLQKsPsEsFIGREKRsNsQsyIGRPI
Q15139 S239 Sugiyama PRKD1 PKD PKD1 PRKCM sAELsTsAPDEPLLQKsPsEsFIGREKRsNsQsyIGRPIHL
Q15139 S247 Sugiyama PRKD1 PKD PKD1 PRKCM PDEPLLQKsPsEsFIGREKRsNsQsyIGRPIHLDKILMSKV
Q15139 S249 Sugiyama PRKD1 PKD PKD1 PRKCM EPLLQKsPsEsFIGREKRsNsQsyIGRPIHLDKILMSKVKV
Q15139 S251 Sugiyama PRKD1 PKD PKD1 PRKCM LLQKsPsEsFIGREKRsNsQsyIGRPIHLDKILMSKVKVPH
Q15139 S397 Sugiyama PRKD1 PKD PKD1 PRKCM NDSGEMQDPDPDHEDANRtIsPstsNNIPLMRVVQsVKHTK
Q15139 S401 Sugiyama PRKD1 PKD PKD1 PRKCM EMQDPDPDHEDANRtIsPstsNNIPLMRVVQsVKHTKRKSs
Q15139 S460 Sugiyama PRKD1 PKD PKD1 PRKCM KRHYWRLDSKCItLFQNDTGsRYyKEIPLSEILsLEPVKTS
Q15139 S68 Sugiyama PRKD1 PKD PKD1 PRKCM GISFHLQIGLSREPVLLLQDsSGDYSLAHVREMACSIVDQK
Q15139 S738 GPS6|SIGNOR|iPTMNet|PSP PRKD1 PKD PKD1 PRKCM DPFPQVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNK
Q15139 S742 GPS6|SIGNOR|iPTMNet|EPSD|PSP|Sugiyama PRKD1 PKD PKD1 PRKCM QVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNKGYNR
Q15139 S910 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP PRKD1 PKD PKD1 PRKCM SHSDTPETEETEMKALGERVsIL__________________
Q15139 T452 Sugiyama PRKD1 PKD PKD1 PRKCM yTSKDTLRKRHYWRLDSKCItLFQNDTGsRYyKEIPLSEIL
Q15139 T746 Sugiyama PRKD1 PKD PKD1 PRKCM CDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNKGYNRSLDM
Q15139 Y252 Sugiyama PRKD1 PKD PKD1 PRKCM LQKsPsEsFIGREKRsNsQsyIGRPIHLDKILMSKVKVPHT
Q15139 Y749 Sugiyama PRKD1 PKD PKD1 PRKCM GFARIIGEKsFRRsVVGtPAyLAPEVLRNKGYNRSLDMWSV
Q15172 S472 Sugiyama PPP2R5A EELWKKLEELKLKKALEKQNsAyNMHSILSNTSAE______
Q15276 S407 EPSD|PSP RABEP1 RAB5EP RABPT5 RABPT5A GDPFSKSDNDMFKDGLRRAQstDsLGtsGsLQSKALGYNYK
Q15459 S690 Sugiyama SF3A1 SAP114 VHPPPPMEDEPTSKKLKTEDsLMPEEEFLRRNKGPVSIKVQ
Q16204 S323 Sugiyama CCDC6 D10S170 TST1 RLQRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQ
Q16204 S325 Sugiyama CCDC6 D10S170 TST1 QRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQGL
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3MII6 S506 Sugiyama TBC1D25 OATL1 DHLATASQGPGGGGRLLRQAsLDGLQQLRDNMGSRRDPLVQ
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF6 Y32 Sugiyama HSP90AB4P KEIFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDII
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF7 Y56 Sugiyama HSP90AB3P HSP90BC EEIFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDII
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 Y56 Sugiyama HSP90AB2P HSP90BB KEIFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDII
Q5H9R7 S579 Sugiyama PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q5T035 S66 Sugiyama FAM120A2P C9orf129 LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI
Q5VT52 S1068 Sugiyama RPRD2 KIAA0460 HSPC099 SLTATDQQQQEEHYRIETRVsssCLDLPDSTEEKGAPIETL
Q5VTE0 T261 Sugiyama EEF1A1P5 EEF1AL3 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
Q6FI81 T250 Sugiyama CIAPIN1 CUA001 PRO0915 ASLRAASCGEGKKRKACKNCtCGLAEELEKEKSREQMSSQP
Q6PID6 S19 Sugiyama TTC33 __MASFGWKRKIGEKVSKVTsQQFEAEAADEKDVVDNDEGN
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7KZI7 S400 GPS6|EPSD|PSP MARK2 EMK1 sADLtNssAPsPsHKVQRsVsANPKQRRFsDQAAGPAIPTS
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86W56 S286 Sugiyama PARG VGSEDVGTGPKNDNKLTRQEsCLGNsPPFEKESEPEsPMDV
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBP7 T228 Sugiyama PCSK9 NARC1 PSEC0052 VPEEDGTRFHRQASKCDsHGtHLAGVVSGRDAGVAKGASMR
Q8NFH8 S631 Sugiyama REPS2 POB1 AIQTAIRKNKEANAVLARLNsELQQQLKEVHQERIALENQL
Q8NI08 S441 Sugiyama NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993 ELSsQTGGGMHKKDTLKECLsLDPEERKKAESQINNSAVEM
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8WUI4 S155 GPS6|SIGNOR|ELM|EPSD|PSP HDAC7 HDAC7A PPVPSLPSDPPEHFPLRKtVsEPNLKLRYKPKKSLERRKNP
Q8WUI4 S181 SIGNOR HDAC7 HDAC7A LRYKPKKSLERRKNPLLRKEsAPPSLRRRPAETLGDSSPSS
Q8WUI4 S358 SIGNOR|EPSD|PSP HDAC7 HDAC7A LMTTERLSGSGLHWPLSRtRsEPLPPSATAPPPPGPMQPRL
Q8WUI4 S486 SIGNOR|EPSD|PSP HDAC7 HDAC7A GDtVLLPLAQGGHRPLsRAQssPAAPAsLSAPEPASQARVL
Q8WYL5 S402 EPSD|PSP SSH1 KIAA1298 SSH1L AKRNHSKCLVHCKMGVSRSAsTVIAYAMKEFGWPLEKAYNY
Q8WYL5 S937 SIGNOR|EPSD|PSP SSH1 KIAA1298 SSH1L KTICYtPTSSSMSSNLTRsssSDSIHsVRGKPGLVKQRTQE
Q8WYL5 S978 SIGNOR|EPSD|PSP SSH1 KIAA1298 SSH1L IETRLRLAGLTVssPLKRSHsLAKLGsLtFstEDLsSEADP
Q8WYL5 S99 SIGNOR SSH1 KIAA1298 SSH1L QVMINLLRCEDRIKLAVRLEsAWADRVRYMVVVYSSGRQDT
Q92918 S171 EPSD|PSP MAP4K1 HPK1 VRLADFGISAQIGAtLARRLsFIGtPYWMAPEVAAVALKGG
Q92934 S118 SIGNOR|EPSD|PSP BAD BBC6 BCL2L8 RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934 S75 SIGNOR|EPSD|PSP BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934 S99 SIGNOR|EPSD|PSP BAD BBC6 BCL2L8 GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q96A00 T38 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP PPP1R14A CPI17 PPP1INL SRARGPGGsPGGLQKRHARVtVKYDRRELQRRLDVEKWIDG
Q96D71 S767 Sugiyama REPS1 AIQAsIRRNKETNTVLARLNsELQQQLKDVLEERISLEVQL
Q96QB1 S1244 SIGNOR|EPSD|PSP DLC1 ARHGAP7 KIAA1723 STARD12 NLAVCLAPSLFHLNTLKRENsSPRVMQRKQSLGKPDQKDLN
Q99543 S275 Sugiyama DNAJC2 MPHOSPH11 MPP11 ZRF1 RAQRKKEEMNRIRtLVDNAysCDPRIKKFKEEEKAKKEAEK
Q99575 S816 Sugiyama POP1 KIAA0061 VAATGSHLCVLRSRKLLKQLsAWCGPSSEDSRGGRRAPGRG
Q99683 T838 EPSD|PSP MAP3K5 ASK1 MAPKKK5 MEKK5 LKISDFGtSKRLAGINPCTEtFTGtLQyMAPEIIDKGPRGY
Q99814 T324 iPTMNet EPAS1 BHLHE73 HIF2A MOP2 PASD2 SGQYRMLAKHGGYVWLETQGtVIYNPRNLQPQCIMCVNYVL
Q99832 S59 Sugiyama CCT7 CCTH NIP7-1 TLGPRGMDKLIVDGRGKAtIsNDGAtILKLLDVVHPAAKTL
Q9BST9 S448 SIGNOR RTKN RTKN1 IMKIEtPAPRKPPQALAKQGsLyHEMAIEPLDDIAAVTDIL
Q9BY44 S528 Sugiyama EIF2A CDA02 MSTP004 MSTP089 DLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKAIE
Q9GZY8 S155 SIGNOR|PSP MFF C2orf33 AD030 AD033 GL004 PPttPQNEEIRAVGRLKRERsMsENAVRQNGQLVRNDsLWH
Q9GZY8 S172 SIGNOR|PSP MFF C2orf33 AD030 AD033 GL004 RERsMsENAVRQNGQLVRNDsLWHRsDsAPRNKISRFQAPI
Q9GZY8 S275 SIGNOR|PSP MFF C2orf33 AD030 AD033 GL004 RGGsAAAtsNPHHDNVRYGIsNIDTTIEGTSDDLTVVDAAS
Q9H0K1 S674 Sugiyama SIK2 KIAA0781 QIK SNF1LK2 QQESVSTLPASVHPQLSPRQsLEtQYLQHRLQKPSLLSKAQ
Q9H6S3 S693 Sugiyama EPS8L2 EPS8R2 PP13181 EGVRVySQLTMQKAFLEKQQsGSELEELMNKFHSMNQRRGE
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H788 S316 Sugiyama SH2D4A PPP1R38 SH2A NSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRAG
Q9H9Q2 S225 Sugiyama COPS7B CSN7B TQQQVEAEVTNIKKTLKAtAsSsAQEMEQQLAERECPPHAE
Q9NPD3 S77 Sugiyama EXOSC4 RRP41 SKI6 EIRGsRARALPDRALVNCQYssATFstGERKRRPHGDRKSC
Q9NPD3 S78 Sugiyama EXOSC4 RRP41 SKI6 IRGsRARALPDRALVNCQYssATFstGERKRRPHGDRKSCE
Q9NRA0 S419 EPSD|PSP SPHK2 SK2 sELtLtPDPAPPMAHsPLHRsVsDLPLPLPQPALASPGSPE
Q9NRA0 S421 EPSD|PSP SPHK2 SK2 LtLtPDPAPPMAHsPLHRsVsDLPLPLPQPALASPGSPEPL
Q9NVR5 S773 Sugiyama DNAAF2 C14orf104 KTU EFIKEKSATCSNEEKDNLNEsVITEEKETDGDHLsSLLNKT
Q9NZB2 S417 Sugiyama FAM120A C9orf10 KIAA0183 OSSA LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI
Q9P258 S44 Sugiyama RCC2 KIAA1470 TD60 GPRKRGGPAGRKRERPERCssssGGGssGDEDGLELDGAPG
Q9P286 S99 PSP PAK5 KIAA1264 PAK7 ETSINGLLEDFDNISVTRSNsLRKESPPTPDQGASSHGPGH
Q9UBF8 S294 SIGNOR|EPSD|PSP PI4KB PIK4CB RsKsDAtAsISLSSNLKRTAsNPKVENEDEELSSSTESIDN
Q9ULD2 S1203 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9ULD2 T1204 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 ENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRLs
Q9ULH0 S918 SIGNOR|iPTMNet KIDINS220 ARMS KIAA1250 LNRRDTYRRRQMQRTITRQMsFDLTKLLVTEDWFSDISPQT
Q9UNH7 S343 Sugiyama SNX6 ANKALDKARAKNKDVLQAETsQQLCCQKFEKISESAKQELI
Q9UPN3 S2769 Sugiyama MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251 EAIEKRLISPELANMIQIDSsEFSDHRAQIEKQEGIEVCAL
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQL6 S259 GPS6|SIGNOR|iPTMNet|EPSD|PSP HDAC5 KIAA0600 KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9UQL6 S498 GPS6|SIGNOR|iPTMNet|EPSD|PSP HDAC5 KIAA0600 ATSMRTVGKLPRHRPLSRtQssPLPQSPQALQQLVMQQQHQ
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y3B8 S203 Sugiyama REXO2 SFN SMFN CGI-114 EYEFAPKKAAsHRALDDIsEsIKELQFyRNNIFKKKIDEKK
Q9Y3E5 S5 SIGNOR|EPSD|PSP PTRH2 BIT1 PTH2 CGI-147 ________________MPSKsLVMEYLAHPSTLGLAVGVAC
Q9Y3E5 S87 SIGNOR|EPSD|PSP PTRH2 BIT1 PTH2 CGI-147 MILVVRNDLKMGKGKVAAQCsHAAVSAYKQIQRRNPEMLKQ
Q9Y580 S136 Sugiyama RBM7 RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Q9Y5B9 S650 Sugiyama SUPT16H FACT140 FACTP140 KRYKTREAEEKEKEGIVKQDsLVINLNRsNPKLKDLYIRPN
Q9Y5P4 S132 SIGNOR|EPSD|PSP CERT1 CERT COL4A3BP STARD11 IEQHKTESGYGsEssLRRHGsMVsLVSGAsGYsAtstssFK
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Attenuation phase R-HSA-3371568 2.382582e-08 7.623 0 0
HSF1-dependent transactivation R-HSA-3371571 2.385983e-08 7.622 0 0
NRAGE signals death through JNK R-HSA-193648 3.994231e-07 6.399 0 0
G alpha (12/13) signalling events R-HSA-416482 9.454599e-07 6.024 0 0
Apoptotic execution phase R-HSA-75153 3.488103e-06 5.457 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.861460e-06 5.104 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.415966e-05 4.849 0 0
HSF1 activation R-HSA-3371511 2.326212e-05 4.633 0 0
Signal Transduction R-HSA-162582 3.534164e-05 4.452 0 0
Cellular response to heat stress R-HSA-3371556 5.175683e-05 4.286 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.823001e-05 4.235 0 0
Death Receptor Signaling R-HSA-73887 6.644394e-05 4.178 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.968440e-05 4.157 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.297380e-04 3.887 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.754537e-04 3.756 0 0
Cellular Senescence R-HSA-2559583 1.767437e-04 3.753 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.302665e-04 3.638 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.681351e-04 3.434 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.765106e-04 3.322 0 0
Cell Cycle R-HSA-1640170 4.771910e-04 3.321 0 0
Chromatin modifying enzymes R-HSA-3247509 4.659962e-04 3.332 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.195161e-04 3.284 0 0
Cell Cycle, Mitotic R-HSA-69278 5.361815e-04 3.271 0 0
Chromatin organization R-HSA-4839726 5.437605e-04 3.265 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.950238e-04 3.002 0 0
Meiotic synapsis R-HSA-1221632 1.266102e-03 2.898 0 0
Signaling by Hippo R-HSA-2028269 1.467160e-03 2.834 0 0
Apoptosis R-HSA-109581 2.078137e-03 2.682 0 0
Notch-HLH transcription pathway R-HSA-350054 2.205188e-03 2.657 0 0
Activation of RAC1 R-HSA-428540 2.341434e-03 2.631 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.436408e-03 2.613 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.436408e-03 2.613 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.691909e-03 2.570 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.823975e-03 2.549 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.873349e-03 2.542 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.604462e-03 2.337 0 0
Meiosis R-HSA-1500620 4.482636e-03 2.348 0 0
Cell Cycle Checkpoints R-HSA-69620 4.623706e-03 2.335 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.075871e-03 2.294 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.079376e-03 2.294 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.051448e-03 2.218 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.051448e-03 2.218 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.051448e-03 2.218 0 0
Neurexins and neuroligins R-HSA-6794361 6.261610e-03 2.203 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.952082e-03 2.158 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.244092e-03 2.140 0 0
ChREBP activates metabolic gene expression R-HSA-163765 7.012343e-03 2.154 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.319671e-03 2.136 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.775647e-03 2.109 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.153046e-03 2.089 0 0
Nervous system development R-HSA-9675108 8.975288e-03 2.047 0 0
Signaling by AXIN mutants R-HSA-4839735 9.623102e-03 2.017 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.042152e-02 1.982 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.078423e-02 1.967 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.286115e-02 1.891 0 0
HDMs demethylate histones R-HSA-3214842 1.280719e-02 1.893 0 0
Signaling by NOTCH1 R-HSA-1980143 1.308194e-02 1.883 0 0
Programmed Cell Death R-HSA-5357801 1.343847e-02 1.872 0 0
Mitotic Prometaphase R-HSA-68877 1.429631e-02 1.845 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.491105e-02 1.826 0 0
RET signaling R-HSA-8853659 1.505519e-02 1.822 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.576717e-02 1.802 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.636072e-02 1.786 0 0
Cellular responses to stimuli R-HSA-8953897 1.585302e-02 1.800 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.718122e-02 1.765 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.645721e-02 1.784 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.717464e-02 1.765 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.658738e-02 1.780 0 0
Signaling by ROBO receptors R-HSA-376176 1.725869e-02 1.763 0 0
M Phase R-HSA-68886 1.740308e-02 1.759 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.763418e-02 1.754 0 0
Cellular responses to stress R-HSA-2262752 1.866080e-02 1.729 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.955625e-02 1.709 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.109069e-02 1.676 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.014673e-02 1.696 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.107130e-02 1.676 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.040155e-02 1.690 0 0
Polo-like kinase mediated events R-HSA-156711 2.109069e-02 1.676 0 0
Invadopodia formation R-HSA-8941237 2.217315e-02 1.654 0 0
Signaling by APC mutants R-HSA-4839744 2.669652e-02 1.574 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.669652e-02 1.574 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.669652e-02 1.574 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.669652e-02 1.574 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.698976e-02 1.569 0 0
Late endosomal microautophagy R-HSA-9615710 2.548381e-02 1.594 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.451827e-02 1.611 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.451827e-02 1.611 0 0
Rab regulation of trafficking R-HSA-9007101 2.606405e-02 1.584 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.511267e-02 1.600 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.812073e-02 1.551 0 0
Neurodegenerative Diseases R-HSA-8863678 2.832048e-02 1.548 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.832048e-02 1.548 0 0
Axon guidance R-HSA-422475 2.871722e-02 1.542 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.875086e-02 1.541 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.969583e-02 1.527 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.210902e-02 1.493 0 0
Regulation of PTEN localization R-HSA-8948747 3.210902e-02 1.493 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.210902e-02 1.493 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.107454e-02 1.508 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.432473e-02 1.464 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.432473e-02 1.464 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.315806e-02 1.479 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.481476e-02 1.458 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.481476e-02 1.458 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.481476e-02 1.458 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.481476e-02 1.458 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.432473e-02 1.464 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.481476e-02 1.458 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.432473e-02 1.464 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 3.517734e-02 1.454 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.708678e-02 1.431 0 0
Co-stimulation by CD28 R-HSA-389356 3.753015e-02 1.426 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.517734e-02 1.454 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.517734e-02 1.454 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.517734e-02 1.454 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.860235e-02 1.413 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.933044e-02 1.405 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.952999e-02 1.403 0 0
Type I hemidesmosome assembly R-HSA-446107 4.296381e-02 1.367 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.317619e-02 1.365 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.317619e-02 1.365 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.317619e-02 1.365 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.317619e-02 1.365 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.317619e-02 1.365 0 0
HDACs deacetylate histones R-HSA-3214815 4.023882e-02 1.395 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.061739e-02 1.391 0 0
Adrenoceptors R-HSA-390696 4.296381e-02 1.367 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.296381e-02 1.367 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.381741e-02 1.358 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.381741e-02 1.358 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.381741e-02 1.358 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.510446e-02 1.346 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.510446e-02 1.346 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.518964e-02 1.345 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 4.973181e-02 1.303 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.013654e-02 1.300 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.809816e-02 1.318 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.973181e-02 1.303 0 0
G2/M Transition R-HSA-69275 5.023817e-02 1.299 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.131531e-02 1.290 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.131531e-02 1.290 0 0
NrCAM interactions R-HSA-447038 5.131531e-02 1.290 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.136542e-02 1.289 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.136542e-02 1.289 0 0
PI Metabolism R-HSA-1483255 5.223727e-02 1.282 0 0
Mitotic Prophase R-HSA-68875 5.231697e-02 1.281 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.563640e-02 1.255 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.327736e-02 1.273 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.327736e-02 1.273 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.408330e-02 1.267 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.794508e-02 1.237 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.327736e-02 1.273 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.794508e-02 1.237 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.923274e-02 1.227 0 0
DNA methylation R-HSA-5334118 5.931200e-02 1.227 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.931200e-02 1.227 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.934014e-02 1.227 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.975952e-02 1.224 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.108749e-02 1.214 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.237186e-02 1.205 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.114091e-01 0.953 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.114091e-01 0.953 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.195056e-02 1.086 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.195056e-02 1.086 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 8.195056e-02 1.086 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.195056e-02 1.086 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.195056e-02 1.086 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.195056e-02 1.086 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.195056e-02 1.086 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.195056e-02 1.086 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.195056e-02 1.086 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.195056e-02 1.086 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.195056e-02 1.086 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.195056e-02 1.086 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.104120e-01 0.677 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.104120e-01 0.677 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.104120e-01 0.677 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.104120e-01 0.677 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.104120e-01 0.677 0 0
Defective SLC2A10 causes arterial tortuosity syndrome (ATS) R-HSA-5619068 2.104120e-01 0.677 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.104120e-01 0.677 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.104120e-01 0.677 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.104120e-01 0.677 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.104120e-01 0.677 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.104120e-01 0.677 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.104120e-01 0.677 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 7.040806e-02 1.152 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 9.220191e-02 1.035 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 9.220191e-02 1.035 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 1.588116e-01 0.799 0 0
HCN channels R-HSA-1296061 1.588116e-01 0.799 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.588116e-01 0.799 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.588116e-01 0.799 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.588116e-01 0.799 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.588116e-01 0.799 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.588116e-01 0.799 0 0
FGFR4 mutant receptor activation R-HSA-1839128 2.983895e-01 0.525 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.983895e-01 0.525 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.983895e-01 0.525 0 0
Intestinal infectious diseases R-HSA-8942233 2.983895e-01 0.525 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.983895e-01 0.525 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.983895e-01 0.525 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.983895e-01 0.525 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.983895e-01 0.525 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.983895e-01 0.525 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.983895e-01 0.525 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 2.983895e-01 0.525 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.983895e-01 0.525 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.983895e-01 0.525 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.983895e-01 0.525 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.983895e-01 0.525 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 2.983895e-01 0.525 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.009873e-02 1.154 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.163958e-01 0.934 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.163958e-01 0.934 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.628908e-02 1.064 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.628908e-02 1.064 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.008593e-01 0.697 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.008593e-01 0.697 0 0
IRS activation R-HSA-74713 2.008593e-01 0.697 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.008593e-01 0.697 0 0
G2 Phase R-HSA-68911 2.008593e-01 0.697 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.008593e-01 0.697 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.234709e-01 0.908 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.234709e-01 0.908 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.706639e-01 0.768 0 0
Calcineurin activates NFAT R-HSA-2025928 1.706639e-01 0.768 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.439827e-01 0.613 0 0
Signaling by MAPK mutants R-HSA-9652817 2.439827e-01 0.613 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.765690e-01 0.424 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.765690e-01 0.424 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.765690e-01 0.424 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.765690e-01 0.424 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.765690e-01 0.424 0 0
Defective visual phototransduction due to STRA6 loss of function R-HSA-9918449 3.765690e-01 0.424 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.000656e-01 0.699 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 2.874208e-01 0.541 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 2.874208e-01 0.541 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.874208e-01 0.541 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.394402e-01 0.856 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.893139e-01 0.723 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.893139e-01 0.723 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.767454e-01 0.753 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.767454e-01 0.753 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.617900e-01 0.582 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.617900e-01 0.582 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.305684e-01 0.481 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.305684e-01 0.481 0 0
SOS-mediated signalling R-HSA-112412 3.305684e-01 0.481 0 0
The IPAF inflammasome R-HSA-844623 4.460412e-01 0.351 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.460412e-01 0.351 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.460412e-01 0.351 0 0
Phenylketonuria R-HSA-2160456 4.460412e-01 0.351 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.460412e-01 0.351 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.460412e-01 0.351 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 4.460412e-01 0.351 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.460412e-01 0.351 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.171982e-01 0.931 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.935211e-01 0.532 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.935211e-01 0.532 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.935211e-01 0.532 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.935211e-01 0.532 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.373892e-02 1.077 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.989327e-01 0.701 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.989327e-01 0.701 0 0
Packaging Of Telomere Ends R-HSA-171306 1.989327e-01 0.701 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 2.636171e-01 0.579 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.729513e-01 0.428 0 0
RSK activation R-HSA-444257 3.729513e-01 0.428 0 0
Regulation by c-FLIP R-HSA-3371378 3.729513e-01 0.428 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.729513e-01 0.428 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.729513e-01 0.428 0 0
Dimerization of procaspase-8 R-HSA-69416 3.729513e-01 0.428 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.729513e-01 0.428 0 0
Formation of annular gap junctions R-HSA-196025 3.729513e-01 0.428 0 0
Centrosome maturation R-HSA-380287 7.310636e-02 1.136 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.132988e-01 0.946 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.254762e-01 0.487 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 9.822155e-02 1.008 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.136983e-02 1.039 0 0
PKA activation in glucagon signalling R-HSA-164378 2.895342e-01 0.538 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.604379e-01 0.584 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.359979e-01 0.627 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.359979e-01 0.627 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.804247e-01 0.744 0 0
Nucleosome assembly R-HSA-774815 1.804247e-01 0.744 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.116511e-01 0.674 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.827006e-01 0.549 0 0
Deadenylation of mRNA R-HSA-429947 2.827006e-01 0.549 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.157756e-01 0.501 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.574205e-01 0.447 0 0
Removal of the Flap Intermediate R-HSA-69166 3.574205e-01 0.447 0 0
ARMS-mediated activation R-HSA-170984 4.142044e-01 0.383 0 0
Lipophagy R-HSA-9613354 4.142044e-01 0.383 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.142044e-01 0.383 0 0
Gap junction degradation R-HSA-190873 4.142044e-01 0.383 0 0
CASP8 activity is inhibited R-HSA-5218900 4.142044e-01 0.383 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.077753e-01 0.294 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.077753e-01 0.294 0 0
MPS VI - Maroteaux-Lamy syndrome R-HSA-2206285 5.077753e-01 0.294 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.077753e-01 0.294 0 0
betaKlotho-mediated ligand binding R-HSA-1307965 5.077753e-01 0.294 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.077753e-01 0.294 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.183538e-01 0.927 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.492635e-01 0.603 0 0
Trafficking of AMPA receptors R-HSA-399719 2.749559e-01 0.561 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.868657e-01 0.728 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.051441e-01 0.978 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.051441e-01 0.978 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 1.558957e-01 0.807 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.422012e-01 0.466 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.422012e-01 0.466 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.422012e-01 0.466 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.422012e-01 0.466 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.669924e-01 0.574 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.498440e-01 0.824 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.891455e-01 0.410 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.281643e-01 0.484 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.152747e-01 0.501 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.540535e-01 0.343 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.540535e-01 0.343 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.511815e-01 0.454 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.511815e-01 0.454 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.949396e-01 0.710 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.846310e-01 0.734 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.820787e-01 0.550 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.820787e-01 0.550 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 4.204685e-01 0.376 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.204685e-01 0.376 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 4.204685e-01 0.376 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.219525e-01 0.492 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.093686e-01 0.510 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.093686e-01 0.510 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.093686e-01 0.510 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.977974e-01 0.526 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.870729e-01 0.542 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.742721e-01 0.427 0 0
HIV elongation arrest and recovery R-HSA-167287 3.742721e-01 0.427 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.742721e-01 0.427 0 0
RAF activation R-HSA-5673000 3.564262e-01 0.448 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.564262e-01 0.448 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.564262e-01 0.448 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.406982e-01 0.468 0 0
Translation initiation complex formation R-HSA-72649 3.137241e-01 0.503 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.922992e-01 0.308 0 0
Activation of AMPA receptors R-HSA-399710 5.626328e-01 0.250 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.626328e-01 0.250 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.626328e-01 0.250 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.626328e-01 0.250 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.626328e-01 0.250 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.626328e-01 0.250 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.626328e-01 0.250 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.626328e-01 0.250 0 0
Defective F9 activation R-HSA-9673221 5.626328e-01 0.250 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.626328e-01 0.250 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.626328e-01 0.250 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.460757e-01 0.461 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.983416e-01 0.525 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.790041e-01 0.421 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.482333e-01 0.458 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.628581e-01 0.440 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.813021e-01 0.318 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.358062e-01 0.474 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.613099e-01 0.442 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.728197e-01 0.325 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 5.288042e-01 0.277 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.288042e-01 0.277 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.288042e-01 0.277 0 0
ERKs are inactivated R-HSA-202670 5.288042e-01 0.277 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.597178e-01 0.338 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.105670e-01 0.292 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.105670e-01 0.292 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.251134e-01 0.371 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.979274e-01 0.303 0 0
HIV Transcription Elongation R-HSA-167169 4.800055e-01 0.319 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.800055e-01 0.319 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.800055e-01 0.319 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.100953e-01 0.292 0 0
Striated Muscle Contraction R-HSA-390522 5.100953e-01 0.292 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.100953e-01 0.292 0 0
Regulation of signaling by CBL R-HSA-912631 5.389357e-01 0.268 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.389357e-01 0.268 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.634814e-01 0.249 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.634814e-01 0.249 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.113795e-01 0.214 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.113795e-01 0.214 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.113795e-01 0.214 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.113795e-01 0.214 0 0
Cam-PDE 1 activation R-HSA-111957 6.113795e-01 0.214 0 0
PKB-mediated events R-HSA-109703 6.113795e-01 0.214 0 0
PDE3B signalling R-HSA-165160 6.113795e-01 0.214 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.113795e-01 0.214 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.113795e-01 0.214 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.113795e-01 0.214 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.113795e-01 0.214 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.113795e-01 0.214 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.113795e-01 0.214 0 0
Viral mRNA Translation R-HSA-192823 4.781261e-01 0.320 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.316800e-01 0.274 0 0
Dual Incision in GG-NER R-HSA-5696400 5.316800e-01 0.274 0 0
PTEN Regulation R-HSA-6807070 4.777433e-01 0.321 0 0
Transcription of the HIV genome R-HSA-167172 5.415804e-01 0.266 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.698385e-01 0.244 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.962849e-01 0.225 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.962849e-01 0.225 0 0
Acetylcholine binding and downstream events R-HSA-181431 5.962849e-01 0.225 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 5.962849e-01 0.225 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.962849e-01 0.225 0 0
mRNA 3'-end processing R-HSA-72187 5.634506e-01 0.249 0 0
Signaling by Erythropoietin R-HSA-9006335 5.924964e-01 0.227 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.185907e-01 0.209 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.169007e-01 0.210 0 0
DAP12 signaling R-HSA-2424491 6.144321e-01 0.212 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.180248e-01 0.209 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.272015e-01 0.203 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.272015e-01 0.203 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.272015e-01 0.203 0 0
FOXO-mediated transcription R-HSA-9614085 6.886148e-02 1.162 0 0
Signaling by FGFR4 R-HSA-5654743 5.584028e-01 0.253 0 0
PIP3 activates AKT signaling R-HSA-1257604 8.802370e-02 1.055 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.552734e-01 0.593 0 0
EGFR downregulation R-HSA-182971 4.431847e-01 0.353 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.588698e-01 0.587 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 5.198321e-01 0.284 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.505546e-02 1.070 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.881167e-01 0.311 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.186174e-01 0.378 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.962849e-01 0.225 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.680993e-01 0.246 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.167508e-01 0.664 0 0
Hedgehog 'off' state R-HSA-5610787 4.391683e-01 0.357 0 0
Signaling by EGFR R-HSA-177929 4.841980e-01 0.315 0 0
Prolonged ERK activation events R-HSA-169893 2.133517e-01 0.671 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.234709e-01 0.908 0 0
G0 and Early G1 R-HSA-1538133 8.538774e-02 1.069 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.989327e-01 0.701 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.281643e-01 0.484 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.927122e-01 0.227 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.924964e-01 0.227 0 0
DNA Double Strand Break Response R-HSA-5693606 1.136727e-01 0.944 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.149877e-01 0.668 0 0
Homology Directed Repair R-HSA-5693538 2.238511e-01 0.650 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.727303e-01 0.429 0 0
Aggrephagy R-HSA-9646399 1.966373e-01 0.706 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.288042e-01 0.277 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.234988e-02 1.084 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.270891e-01 0.644 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.422012e-01 0.466 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.891455e-01 0.410 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.714805e-01 0.766 0 0
p75NTR signals via NF-kB R-HSA-193639 7.724417e-02 1.112 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 7.306886e-02 1.136 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 1.642745e-01 0.784 0 0
Frs2-mediated activation R-HSA-170968 3.254762e-01 0.487 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.357787e-01 0.474 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 5.936505e-01 0.226 0 0
DCC mediated attractive signaling R-HSA-418885 1.893139e-01 0.723 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.381718e-01 0.623 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.827006e-01 0.549 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.574205e-01 0.447 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.142044e-01 0.383 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.152747e-01 0.501 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.152747e-01 0.501 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.846310e-01 0.734 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.056459e-01 0.687 0 0
MAP2K and MAPK activation R-HSA-5674135 3.595751e-01 0.444 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.788829e-01 0.421 0 0
PI3K Cascade R-HSA-109704 5.280398e-01 0.277 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.962849e-01 0.225 0 0
TCR signaling R-HSA-202403 5.788479e-01 0.237 0 0
Generation of second messenger molecules R-HSA-202433 1.097446e-01 0.960 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.733128e-01 0.325 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.381718e-01 0.623 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.056459e-01 0.687 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.938478e-01 0.713 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 7.724417e-02 1.112 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.662172e-01 0.779 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.538774e-02 1.069 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.120497e-01 0.951 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.544685e-01 0.811 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.729513e-01 0.428 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.053072e-01 0.515 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.053072e-01 0.515 0 0
PI3K/AKT activation R-HSA-198203 4.540535e-01 0.343 0 0
Peptide chain elongation R-HSA-156902 2.622149e-01 0.581 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.733547e-01 0.563 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.840350e-01 0.234 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.939244e-01 0.405 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.785357e-01 0.422 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.482333e-01 0.458 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.203487e-01 0.376 0 0
Signaling by RAS mutants R-HSA-6802949 3.093686e-01 0.510 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.712076e-01 0.567 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.431847e-01 0.353 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.676952e-01 0.572 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.435744e-01 0.464 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.588116e-01 0.799 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.426622e-01 0.846 0 0
cGMP effects R-HSA-418457 1.662172e-01 0.779 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.133517e-01 0.671 0 0
NF-kB is activated and signals survival R-HSA-209560 2.617900e-01 0.582 0 0
TGFBR3 expression R-HSA-9839394 1.642745e-01 0.784 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.935211e-01 0.532 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.327617e-02 1.199 0 0
PKA activation R-HSA-163615 2.895342e-01 0.538 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.116511e-01 0.674 0 0
Regulation of gap junction activity R-HSA-191650 5.077753e-01 0.294 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.167508e-01 0.664 0 0
Separation of Sister Chromatids R-HSA-2467813 1.397559e-01 0.855 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.923302e-01 0.406 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.406925e-01 0.356 0 0
Ligand-receptor interactions R-HSA-5632681 6.113795e-01 0.214 0 0
Formation of axial mesoderm R-HSA-9796292 5.962849e-01 0.225 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.734943e-01 0.241 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.424777e-02 1.192 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.424777e-02 1.192 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.724323e-01 0.242 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 2.604379e-01 0.584 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.640039e-01 0.249 0 0
Signaling by NOTCH3 R-HSA-9012852 3.298273e-01 0.482 0 0
Hedgehog 'on' state R-HSA-5632684 4.562300e-01 0.341 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.281643e-01 0.484 0 0
TNF signaling R-HSA-75893 3.460757e-01 0.461 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.392390e-01 0.357 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.225060e-01 0.282 0 0
Long-term potentiation R-HSA-9620244 7.826874e-02 1.106 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.874208e-01 0.541 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.935211e-01 0.532 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.124189e-02 1.040 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.905193e-01 0.720 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.281643e-01 0.484 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.686791e-01 0.433 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.771549e-01 0.423 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.337086e-01 0.477 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.516709e-01 0.258 0 0
Meiotic recombination R-HSA-912446 9.592872e-02 1.018 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.392390e-01 0.357 0 0
Intra-Golgi traffic R-HSA-6811438 5.198321e-01 0.284 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.132657e-01 0.212 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.042194e-02 1.095 0 0
Post NMDA receptor activation events R-HSA-438064 1.711066e-01 0.767 0 0
Signaling by WNT in cancer R-HSA-4791275 1.672325e-01 0.777 0 0
Mitotic Anaphase R-HSA-68882 7.697236e-02 1.114 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.198321e-01 0.284 0 0
Activation of BH3-only proteins R-HSA-114452 1.383327e-01 0.859 0 0
GPVI-mediated activation cascade R-HSA-114604 2.492635e-01 0.603 0 0
Cellular response to starvation R-HSA-9711097 5.109505e-01 0.292 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.673264e-01 0.573 0 0
Signaling by VEGF R-HSA-194138 1.130191e-01 0.947 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.282327e-01 0.277 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 7.040806e-02 1.152 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.463644e-02 1.190 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.383327e-01 0.859 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.142044e-01 0.383 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.846310e-01 0.734 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.317415e-01 0.635 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.470854e-02 1.072 0 0
Activation of AKT2 R-HSA-165158 5.626328e-01 0.250 0 0
G2/M Checkpoints R-HSA-69481 4.139644e-01 0.383 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.962849e-01 0.225 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.927122e-01 0.227 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.907631e-01 0.229 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.272015e-01 0.203 0 0
G-protein mediated events R-HSA-112040 2.770709e-01 0.557 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.998307e-01 0.523 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.730281e-01 0.325 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.480051e-01 0.349 0 0
Cyclin D associated events in G1 R-HSA-69231 2.755897e-01 0.560 0 0
G1 Phase R-HSA-69236 2.755897e-01 0.560 0 0
IGF1R signaling cascade R-HSA-2428924 6.153893e-01 0.211 0 0
TBC/RABGAPs R-HSA-8854214 8.524653e-02 1.069 0 0
Ephrin signaling R-HSA-3928664 2.895342e-01 0.538 0 0
Lagging Strand Synthesis R-HSA-69186 5.927122e-01 0.227 0 0
Semaphorin interactions R-HSA-373755 1.413133e-01 0.850 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.394402e-01 0.856 0 0
Oncogene Induced Senescence R-HSA-2559585 3.771549e-01 0.423 0 0
Signaling by NOTCH R-HSA-157118 2.403714e-01 0.619 0 0
Circadian clock R-HSA-9909396 3.890738e-01 0.410 0 0
Opioid Signalling R-HSA-111885 4.910249e-01 0.309 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.935211e-01 0.532 0 0
mTORC1-mediated signalling R-HSA-166208 4.213130e-01 0.375 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.896201e-01 0.538 0 0
Integration of energy metabolism R-HSA-163685 3.550436e-01 0.450 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.161607e-01 0.287 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.983416e-01 0.525 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.152747e-01 0.501 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.053072e-01 0.515 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.319125e-01 0.635 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.595751e-01 0.444 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.317639e-01 0.880 0 0
FasL/ CD95L signaling R-HSA-75157 4.460412e-01 0.351 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.460412e-01 0.351 0 0
HATs acetylate histones R-HSA-3214847 6.886148e-02 1.162 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.077753e-01 0.294 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.213130e-01 0.375 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 4.512320e-01 0.346 0 0
Eukaryotic Translation Termination R-HSA-72764 3.741859e-01 0.427 0 0
Cilium Assembly R-HSA-5617833 3.461179e-01 0.461 0 0
S Phase R-HSA-69242 4.948154e-01 0.306 0 0
Processing of SMDT1 R-HSA-8949664 5.962849e-01 0.225 0 0
Gene expression (Transcription) R-HSA-74160 4.017893e-01 0.396 0 0
Diseases of programmed cell death R-HSA-9645723 7.386139e-02 1.132 0 0
PKMTs methylate histone lysines R-HSA-3214841 6.276126e-02 1.202 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.909670e-01 0.536 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.281643e-01 0.484 0 0
ESR-mediated signaling R-HSA-8939211 1.316873e-01 0.880 0 0
Membrane Trafficking R-HSA-199991 9.550362e-02 1.020 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.023396e-01 0.220 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.321176e-01 0.479 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 9.220191e-02 1.035 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.152747e-01 0.501 0 0
ERK/MAPK targets R-HSA-198753 3.686791e-01 0.433 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 3.973537e-01 0.401 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.186174e-01 0.378 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.288042e-01 0.277 0 0
RNA Polymerase II Transcription R-HSA-73857 3.537887e-01 0.451 0 0
Signaling by TGFB family members R-HSA-9006936 4.444412e-01 0.352 0 0
Calmodulin induced events R-HSA-111933 2.492635e-01 0.603 0 0
PLC beta mediated events R-HSA-112043 1.988589e-01 0.701 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.881167e-01 0.311 0 0
Cleavage of the damaged purine R-HSA-110331 2.669924e-01 0.574 0 0
Autophagy R-HSA-9612973 4.033137e-01 0.394 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.001021e-01 0.398 0 0
Ub-specific processing proteases R-HSA-5689880 3.394191e-01 0.469 0 0
MAPK family signaling cascades R-HSA-5683057 6.312026e-02 1.200 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.896201e-01 0.538 0 0
Generic Transcription Pathway R-HSA-212436 3.267225e-01 0.486 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.525729e-01 0.453 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.242130e-01 0.205 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.573836e-01 0.447 0 0
CaM pathway R-HSA-111997 2.492635e-01 0.603 0 0
Signaling by SCF-KIT R-HSA-1433557 5.584028e-01 0.253 0 0
DAG and IP3 signaling R-HSA-1489509 1.026378e-01 0.989 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.684413e-01 0.774 0 0
Deubiquitination R-HSA-5688426 1.439303e-01 0.842 0 0
Macroautophagy R-HSA-1632852 5.927040e-01 0.227 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.270891e-01 0.644 0 0
Depurination R-HSA-73927 2.850501e-01 0.545 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.717032e-01 0.326 0 0
Heme signaling R-HSA-9707616 7.712492e-02 1.113 0 0
Selective autophagy R-HSA-9663891 3.620199e-01 0.441 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 9.976408e-02 1.001 0 0
Adipogenesis R-HSA-9843745 2.931602e-01 0.533 0 0
HIV Life Cycle R-HSA-162587 4.135722e-01 0.383 0 0
Signaling by PTK6 R-HSA-8848021 1.413133e-01 0.850 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.413133e-01 0.850 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.296030e-01 0.482 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.187863e-01 0.925 0 0
MTF1 activates gene expression R-HSA-5660489 1.588116e-01 0.799 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.008593e-01 0.697 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.706639e-01 0.768 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.765690e-01 0.424 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.765690e-01 0.424 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 3.765690e-01 0.424 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.765690e-01 0.424 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.442188e-01 0.841 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.039968e-01 0.983 0 0
CREB phosphorylation R-HSA-199920 2.874208e-01 0.541 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.305431e-01 0.637 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.324951e-01 0.878 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.460412e-01 0.351 0 0
MET interacts with TNS proteins R-HSA-8875513 4.460412e-01 0.351 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.460412e-01 0.351 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.672325e-01 0.777 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.989327e-01 0.701 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.729513e-01 0.428 0 0
Co-stimulation by ICOS R-HSA-9927354 3.729513e-01 0.428 0 0
Smooth Muscle Contraction R-HSA-445355 1.132988e-01 0.946 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.131365e-01 0.946 0 0
Regulation of KIT signaling R-HSA-1433559 3.574205e-01 0.447 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.077753e-01 0.294 0 0
Budding and maturation of HIV virion R-HSA-162588 2.749559e-01 0.561 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.891455e-01 0.410 0 0
Myogenesis R-HSA-525793 3.281643e-01 0.484 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.540535e-01 0.343 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.564262e-01 0.448 0 0
Kinesins R-HSA-983189 4.119000e-01 0.385 0 0
Cytoprotection by HMOX1 R-HSA-9707564 3.906453e-01 0.408 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.597178e-01 0.338 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.105670e-01 0.292 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.800055e-01 0.319 0 0
Metalloprotease DUBs R-HSA-5689901 5.225060e-01 0.282 0 0
TRAIL signaling R-HSA-75158 6.113795e-01 0.214 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.113795e-01 0.214 0 0
Phosphorylation of Emi1 R-HSA-176417 6.113795e-01 0.214 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.113795e-01 0.214 0 0
Formation of the Editosome R-HSA-75094 6.113795e-01 0.214 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.113795e-01 0.214 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.464939e-01 0.262 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.698385e-01 0.244 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.962849e-01 0.225 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.469068e-01 0.262 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.927122e-01 0.227 0 0
DARPP-32 events R-HSA-180024 5.924964e-01 0.227 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 5.924964e-01 0.227 0 0
HIV Infection R-HSA-162906 6.121096e-01 0.213 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.470214e-01 0.607 0 0
Inositol phosphate metabolism R-HSA-1483249 3.955808e-01 0.403 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.145828e-01 0.211 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.907631e-01 0.229 0 0
Ca-dependent events R-HSA-111996 3.785357e-01 0.422 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.137740e-01 0.944 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.092345e-01 0.962 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.242141e-01 0.489 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.853198e-01 0.414 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 9.729584e-02 1.012 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.439306e-01 0.613 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.540535e-01 0.343 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.460757e-01 0.461 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.850709e-02 1.164 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.826036e-01 0.738 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.317918e-01 0.274 0 0
Muscle contraction R-HSA-397014 5.569204e-01 0.254 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.931791e-01 0.533 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.985363e-01 0.702 0 0
The NLRP3 inflammasome R-HSA-844456 3.157756e-01 0.501 0 0
FLT3 signaling in disease R-HSA-9682385 5.734943e-01 0.241 0 0
FLT3 Signaling R-HSA-9607240 1.202611e-01 0.920 0 0
Signaling by WNT R-HSA-195721 4.283546e-01 0.368 0 0
Glycolysis R-HSA-70171 3.359009e-01 0.474 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.458088e-02 1.073 0 0
Rap1 signalling R-HSA-392517 3.157756e-01 0.501 0 0
Signal attenuation R-HSA-74749 4.540535e-01 0.343 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.512320e-01 0.346 0 0
Selenocysteine synthesis R-HSA-2408557 3.481399e-01 0.458 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.225060e-01 0.282 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.009873e-02 1.154 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.152747e-01 0.501 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.785357e-01 0.422 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.698385e-01 0.244 0 0
Netrin-1 signaling R-HSA-373752 5.771340e-01 0.239 0 0
RUNX2 regulates bone development R-HSA-8941326 2.492635e-01 0.603 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.855685e-01 0.232 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.855685e-01 0.232 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.540614e-01 0.595 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.439827e-01 0.613 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.442188e-01 0.841 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.662172e-01 0.779 0 0
Nef and signal transduction R-HSA-164944 2.874208e-01 0.541 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.893139e-01 0.723 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.729513e-01 0.428 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.729513e-01 0.428 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.077753e-01 0.294 0 0
Basigin interactions R-HSA-210991 3.686791e-01 0.433 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.626328e-01 0.250 0 0
Signaling by LTK R-HSA-9842663 5.634814e-01 0.249 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.113795e-01 0.214 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.113795e-01 0.214 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.113795e-01 0.214 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.210746e-01 0.283 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.923603e-01 0.534 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.584406e-01 0.253 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.875120e-01 0.231 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.587775e-01 0.799 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.973537e-01 0.401 0 0
Cell junction organization R-HSA-446728 4.686596e-01 0.329 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.381718e-01 0.623 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.895342e-01 0.538 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.826036e-01 0.738 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.386145e-01 0.622 0 0
Inflammasomes R-HSA-622312 3.742721e-01 0.427 0 0
Cell-Cell communication R-HSA-1500931 4.381459e-01 0.358 0 0
Glucose metabolism R-HSA-70326 4.804423e-01 0.318 0 0
Signaling by TGFBR3 R-HSA-9839373 4.543109e-01 0.343 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.044644e-01 0.297 0 0
Reproduction R-HSA-1474165 1.052373e-01 0.978 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.330996e-01 0.632 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.628908e-02 1.064 0 0
Disorders of Developmental Biology R-HSA-9675151 1.060889e-01 0.974 0 0
Synthesis of PI R-HSA-1483226 2.305431e-01 0.637 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.359979e-01 0.627 0 0
Protein methylation R-HSA-8876725 3.891455e-01 0.410 0 0
Amine ligand-binding receptors R-HSA-375280 2.755897e-01 0.560 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.152747e-01 0.501 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.686791e-01 0.433 0 0
PTK6 Down-Regulation R-HSA-8849472 5.626328e-01 0.250 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.626328e-01 0.250 0 0
Defective pyroptosis R-HSA-9710421 3.975334e-01 0.401 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.543109e-01 0.343 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.494055e-01 0.347 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.113795e-01 0.214 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.113795e-01 0.214 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.316800e-01 0.274 0 0
Creatine metabolism R-HSA-71288 5.663358e-01 0.247 0 0
Glutathione synthesis and recycling R-HSA-174403 6.180248e-01 0.209 0 0
NGF-stimulated transcription R-HSA-9031628 2.219027e-01 0.654 0 0
Signaling by NTRKs R-HSA-166520 3.228257e-01 0.491 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.865026e-01 0.543 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.973537e-01 0.401 0 0
Regulation of TP53 Activity R-HSA-5633007 1.172850e-01 0.931 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.358062e-01 0.474 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.240883e-01 0.489 0 0
MAP kinase activation R-HSA-450294 5.680993e-01 0.246 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.354427e-01 0.474 0 0
Nephrin family interactions R-HSA-373753 5.663358e-01 0.247 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.776351e-01 0.321 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.706639e-01 0.768 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.039968e-01 0.983 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.142529e-01 0.383 0 0
Signaling by ALK in cancer R-HSA-9700206 3.358062e-01 0.474 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.142044e-01 0.383 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.540535e-01 0.343 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.922992e-01 0.308 0 0
PECAM1 interactions R-HSA-210990 4.922992e-01 0.308 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.406925e-01 0.356 0 0
OAS antiviral response R-HSA-8983711 2.935211e-01 0.532 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.765989e-01 0.558 0 0
Diseases of DNA repair R-HSA-9675135 6.133520e-01 0.212 0 0
Interleukin-2 family signaling R-HSA-451927 1.966373e-01 0.706 0 0
Dopamine receptors R-HSA-390651 1.588116e-01 0.799 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.439827e-01 0.613 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.765690e-01 0.424 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.305684e-01 0.481 0 0
Interleukin-18 signaling R-HSA-9012546 3.729513e-01 0.428 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.077753e-01 0.294 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 4.204685e-01 0.376 0 0
Co-inhibition by BTLA R-HSA-9927353 5.626328e-01 0.250 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.494055e-01 0.347 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.979274e-01 0.303 0 0
Polymerase switching R-HSA-69091 5.634814e-01 0.249 0 0
Leading Strand Synthesis R-HSA-69109 5.634814e-01 0.249 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.113795e-01 0.214 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.113795e-01 0.214 0 0
Base Excision Repair R-HSA-73884 5.031729e-01 0.298 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.464939e-01 0.262 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.966724e-01 0.706 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 4.204685e-01 0.376 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.620392e-01 0.250 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.979044e-01 0.400 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.000574e-01 0.301 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.812719e-01 0.742 0 0
Interleukin-7 signaling R-HSA-1266695 3.053072e-01 0.515 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.010660e-01 0.697 0 0
Platelet sensitization by LDL R-HSA-432142 2.895342e-01 0.538 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.813021e-01 0.318 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.915779e-01 0.308 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.047953e-01 0.218 0 0
Signaling by ALK R-HSA-201556 4.597178e-01 0.338 0 0
Formation of the nephric duct R-HSA-9830364 4.979274e-01 0.303 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.415758e-01 0.849 0 0
Disorders of Nervous System Development R-HSA-9697154 1.234709e-01 0.908 0 0
Pervasive developmental disorders R-HSA-9005895 1.234709e-01 0.908 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.234709e-01 0.908 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.729513e-01 0.428 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.142044e-01 0.383 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.540535e-01 0.343 0 0
PKR-mediated signaling R-HSA-9833482 3.486170e-01 0.458 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.813021e-01 0.318 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.813021e-01 0.318 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.597178e-01 0.338 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.113795e-01 0.214 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.113795e-01 0.214 0 0
Signal regulatory protein family interactions R-HSA-391160 6.272015e-01 0.203 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.800993e-02 1.009 0 0
Regulation of beta-cell development R-HSA-186712 3.953802e-01 0.403 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.132657e-01 0.212 0 0
Mismatch Repair R-HSA-5358508 5.105670e-01 0.292 0 0
Interleukin-15 signaling R-HSA-8983432 5.634814e-01 0.249 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.479979e-01 0.830 0 0
Signaling by Leptin R-HSA-2586552 2.000656e-01 0.699 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.785357e-01 0.422 0 0
Depyrimidination R-HSA-73928 3.785357e-01 0.422 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.149877e-01 0.668 0 0
Growth hormone receptor signaling R-HSA-982772 4.472544e-01 0.349 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.113795e-01 0.214 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.142044e-01 0.383 0 0
Interleukin-12 signaling R-HSA-9020591 2.005667e-01 0.698 0 0
Assembly Of The HIV Virion R-HSA-175474 3.950872e-01 0.403 0 0
Interleukin-37 signaling R-HSA-9008059 2.552734e-01 0.593 0 0
Interleukin-12 family signaling R-HSA-447115 3.486848e-01 0.458 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.316800e-01 0.274 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.303288e-01 0.200 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.305329e-01 0.200 0 0
Signaling by ERBB4 R-HSA-1236394 6.311823e-01 0.200 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.323158e-01 0.199 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.346356e-01 0.197 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.346356e-01 0.197 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.346356e-01 0.197 0 0
Regulation of insulin secretion R-HSA-422356 6.346356e-01 0.197 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.353582e-01 0.197 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.356180e-01 0.197 0 0
Downstream signal transduction R-HSA-186763 6.356180e-01 0.197 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.395961e-01 0.194 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.399467e-01 0.194 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.422472e-01 0.192 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.422472e-01 0.192 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.454268e-01 0.190 0 0
IRS-mediated signalling R-HSA-112399 6.461146e-01 0.190 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.507813e-01 0.187 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.507813e-01 0.187 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 6.507813e-01 0.187 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.507813e-01 0.187 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.507813e-01 0.187 0 0
Signaling by Hedgehog R-HSA-5358351 6.526274e-01 0.185 0 0
Signaling by LTK in cancer R-HSA-9842640 6.546956e-01 0.184 0 0
Chylomicron clearance R-HSA-8964026 6.546956e-01 0.184 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.546956e-01 0.184 0 0
STAT5 Activation R-HSA-9645135 6.546956e-01 0.184 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.546956e-01 0.184 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.546956e-01 0.184 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.546956e-01 0.184 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.546956e-01 0.184 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.546956e-01 0.184 0 0
Lipid particle organization R-HSA-8964572 6.546956e-01 0.184 0 0
DNA strand elongation R-HSA-69190 6.560335e-01 0.183 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.562444e-01 0.183 0 0
Erythropoietin activates RAS R-HSA-9027284 6.562444e-01 0.183 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.562444e-01 0.183 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.562444e-01 0.183 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.562444e-01 0.183 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.562444e-01 0.183 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.562444e-01 0.183 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.562444e-01 0.183 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.562444e-01 0.183 0 0
Other semaphorin interactions R-HSA-416700 6.562444e-01 0.183 0 0
EPH-Ephrin signaling R-HSA-2682334 6.584276e-01 0.181 0 0
UCH proteinases R-HSA-5689603 6.588619e-01 0.181 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.588619e-01 0.181 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.592071e-01 0.181 0 0
Cellular response to chemical stress R-HSA-9711123 6.600619e-01 0.180 0 0
DNA Damage Bypass R-HSA-73893 6.642596e-01 0.178 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.642596e-01 0.178 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.642596e-01 0.178 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.653649e-01 0.177 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.653649e-01 0.177 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.653649e-01 0.177 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.686467e-01 0.175 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.704669e-01 0.174 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.718153e-01 0.173 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.756646e-01 0.170 0 0
Integrin signaling R-HSA-354192 6.756646e-01 0.170 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.756646e-01 0.170 0 0
Cardiogenesis R-HSA-9733709 6.756646e-01 0.170 0 0
G-protein beta:gamma signalling R-HSA-397795 6.756646e-01 0.170 0 0
snRNP Assembly R-HSA-191859 6.764673e-01 0.170 0 0
Metabolism of non-coding RNA R-HSA-194441 6.764673e-01 0.170 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.815145e-01 0.167 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.815145e-01 0.167 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.818706e-01 0.166 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.834470e-01 0.165 0 0
Phosphorylation of the APC/C R-HSA-176412 6.834470e-01 0.165 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.834470e-01 0.165 0 0
Regulation of BACH1 activity R-HSA-9708530 6.834470e-01 0.165 0 0
Negative regulation of FLT3 R-HSA-9706369 6.834470e-01 0.165 0 0
Activation of SMO R-HSA-5635838 6.834470e-01 0.165 0 0
Killing mechanisms R-HSA-9664420 6.834470e-01 0.165 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.834470e-01 0.165 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.836567e-01 0.165 0 0
RNA Polymerase I Transcription R-HSA-73864 6.853016e-01 0.164 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.859009e-01 0.164 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.859009e-01 0.164 0 0
HIV Transcription Initiation R-HSA-167161 6.859009e-01 0.164 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.859009e-01 0.164 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.873737e-01 0.163 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.873737e-01 0.163 0 0
Complex III assembly R-HSA-9865881 6.873737e-01 0.163 0 0
Interferon gamma signaling R-HSA-877300 6.924885e-01 0.160 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.931859e-01 0.159 0 0
Recycling of eIF2:GDP R-HSA-72731 6.931859e-01 0.159 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.931859e-01 0.159 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.931859e-01 0.159 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.931859e-01 0.159 0 0
PTK6 Expression R-HSA-8849473 6.931859e-01 0.159 0 0
mRNA Editing: C to U Conversion R-HSA-72200 6.931859e-01 0.159 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.931859e-01 0.159 0 0
Cysteine formation from homocysteine R-HSA-1614603 6.931859e-01 0.159 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.931859e-01 0.159 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.931859e-01 0.159 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.931859e-01 0.159 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.931859e-01 0.159 0 0
VLDL clearance R-HSA-8964046 6.931859e-01 0.159 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.931859e-01 0.159 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.931859e-01 0.159 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.931859e-01 0.159 0 0
CHL1 interactions R-HSA-447041 6.931859e-01 0.159 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.931859e-01 0.159 0 0
Maturation of replicase proteins R-HSA-9694301 6.931859e-01 0.159 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.945031e-01 0.158 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.945031e-01 0.158 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.949365e-01 0.158 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.971988e-01 0.157 0 0
Interleukin-17 signaling R-HSA-448424 7.010446e-01 0.154 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 7.051330e-01 0.152 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.082787e-01 0.150 0 0
Tight junction interactions R-HSA-420029 7.082787e-01 0.150 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.082787e-01 0.150 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.088587e-01 0.149 0 0
Phase 2 - plateau phase R-HSA-5576893 7.088587e-01 0.149 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.088587e-01 0.149 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.088587e-01 0.149 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 7.088587e-01 0.149 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.088587e-01 0.149 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.088587e-01 0.149 0 0
Response to metal ions R-HSA-5660526 7.088587e-01 0.149 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.107347e-01 0.148 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.107347e-01 0.148 0 0
Signal amplification R-HSA-392518 7.125460e-01 0.147 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.125460e-01 0.147 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.125460e-01 0.147 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.133386e-01 0.147 0 0
RSV-host interactions R-HSA-9833110 7.148366e-01 0.146 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.167837e-01 0.145 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.167837e-01 0.145 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.185490e-01 0.144 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.185490e-01 0.144 0 0
Influenza Infection R-HSA-168255 7.186112e-01 0.144 0 0
Mitochondrial protein import R-HSA-1268020 7.188172e-01 0.143 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.188172e-01 0.143 0 0
Chromosome Maintenance R-HSA-73886 7.220486e-01 0.141 0 0
Phospholipid metabolism R-HSA-1483257 7.247311e-01 0.140 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.273878e-01 0.138 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.273878e-01 0.138 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.273878e-01 0.138 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.273878e-01 0.138 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.273878e-01 0.138 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.273878e-01 0.138 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.273878e-01 0.138 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.273878e-01 0.138 0 0
Sodium/Proton exchangers R-HSA-425986 7.273878e-01 0.138 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.273878e-01 0.138 0 0
Telomere Maintenance R-HSA-157579 7.276532e-01 0.138 0 0
TRP channels R-HSA-3295583 7.280922e-01 0.138 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 7.280922e-01 0.138 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.280922e-01 0.138 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.291786e-01 0.137 0 0
Signalling to ERKs R-HSA-187687 7.297954e-01 0.137 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.325408e-01 0.135 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.325408e-01 0.135 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.325408e-01 0.135 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.325408e-01 0.135 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.325408e-01 0.135 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.325408e-01 0.135 0 0
Specification of primordial germ cells R-HSA-9827857 7.325408e-01 0.135 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.361477e-01 0.133 0 0
Vesicle-mediated transport R-HSA-5653656 7.444755e-01 0.128 0 0
Insulin receptor signalling cascade R-HSA-74751 7.448725e-01 0.128 0 0
Gene Silencing by RNA R-HSA-211000 7.455707e-01 0.128 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.468334e-01 0.127 0 0
Cristae formation R-HSA-8949613 7.468334e-01 0.127 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.468334e-01 0.127 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.468334e-01 0.127 0 0
Adherens junctions interactions R-HSA-418990 7.485417e-01 0.126 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.487046e-01 0.126 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.487046e-01 0.126 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.487046e-01 0.126 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.487046e-01 0.126 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.487046e-01 0.126 0 0
Signaling by FGFR3 R-HSA-5654741 7.487046e-01 0.126 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.487046e-01 0.126 0 0
Signaling by FGFR in disease R-HSA-1226099 7.507719e-01 0.124 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.538611e-01 0.123 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.545629e-01 0.122 0 0
GAB1 signalosome R-HSA-180292 7.545629e-01 0.122 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.545629e-01 0.122 0 0
Nephron development R-HSA-9831926 7.545629e-01 0.122 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.545629e-01 0.122 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.577788e-01 0.120 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.577788e-01 0.120 0 0
Interleukin-21 signaling R-HSA-9020958 7.577788e-01 0.120 0 0
ALK mutants bind TKIs R-HSA-9700645 7.577788e-01 0.120 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.577788e-01 0.120 0 0
Degradation of GABA R-HSA-916853 7.577788e-01 0.120 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.577788e-01 0.120 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.577788e-01 0.120 0 0
Unwinding of DNA R-HSA-176974 7.577788e-01 0.120 0 0
WNT mediated activation of DVL R-HSA-201688 7.577788e-01 0.120 0 0
mRNA Editing R-HSA-75072 7.577788e-01 0.120 0 0
Interleukin-1 processing R-HSA-448706 7.577788e-01 0.120 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.577788e-01 0.120 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.577788e-01 0.120 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.577788e-01 0.120 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.583639e-01 0.120 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.619411e-01 0.118 0 0
NCAM1 interactions R-HSA-419037 7.619411e-01 0.118 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.628540e-01 0.118 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.645265e-01 0.117 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.645265e-01 0.117 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.647907e-01 0.116 0 0
Signaling by FGFR1 R-HSA-5654736 7.655357e-01 0.116 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.695979e-01 0.114 0 0
Mitochondrial biogenesis R-HSA-1592230 7.707776e-01 0.113 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.726439e-01 0.112 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.750008e-01 0.111 0 0
Specification of the neural plate border R-HSA-9834899 7.750008e-01 0.111 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.750008e-01 0.111 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.750008e-01 0.111 0 0
Interferon Signaling R-HSA-913531 7.750494e-01 0.111 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.768602e-01 0.110 0 0
mRNA Splicing R-HSA-72172 7.770910e-01 0.110 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.812003e-01 0.107 0 0
Platelet calcium homeostasis R-HSA-418360 7.812003e-01 0.107 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.823966e-01 0.107 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.847834e-01 0.105 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 7.847834e-01 0.105 0 0
CASP4 inflammasome assembly R-HSA-9948001 7.847834e-01 0.105 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.847834e-01 0.105 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.847834e-01 0.105 0 0
Pexophagy R-HSA-9664873 7.847834e-01 0.105 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.847834e-01 0.105 0 0
Maturation of spike protein R-HSA-9683686 7.847834e-01 0.105 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.847834e-01 0.105 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.847834e-01 0.105 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.847834e-01 0.105 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.847834e-01 0.105 0 0
Serotonin receptors R-HSA-390666 7.847834e-01 0.105 0 0
Formation of apoptosome R-HSA-111458 7.847834e-01 0.105 0 0
Regulation of CDH11 function R-HSA-9762292 7.847834e-01 0.105 0 0
Cell-cell junction organization R-HSA-421270 7.863813e-01 0.104 0 0
Gluconeogenesis R-HSA-70263 7.893297e-01 0.103 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.910302e-01 0.102 0 0
Regulated Necrosis R-HSA-5218859 7.917358e-01 0.101 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.917358e-01 0.101 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.939340e-01 0.100 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.939340e-01 0.100 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.939340e-01 0.100 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.939340e-01 0.100 0 0
Negative regulation of MET activity R-HSA-6807004 7.939340e-01 0.100 0 0
Signaling by NODAL R-HSA-1181150 7.939340e-01 0.100 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 7.939340e-01 0.100 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.968870e-01 0.099 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.968870e-01 0.099 0 0
Activation of the pre-replicative complex R-HSA-68962 7.968870e-01 0.099 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.968870e-01 0.099 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.009905e-01 0.096 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.013025e-01 0.096 0 0
Sensory processing of sound R-HSA-9659379 8.043507e-01 0.095 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.044691e-01 0.094 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.044691e-01 0.094 0 0
PPARA activates gene expression R-HSA-1989781 8.071329e-01 0.093 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.087788e-01 0.092 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.087788e-01 0.092 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.087788e-01 0.092 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.087788e-01 0.092 0 0
Bicarbonate transporters R-HSA-425381 8.087788e-01 0.092 0 0
LGI-ADAM interactions R-HSA-5682910 8.087788e-01 0.092 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.087788e-01 0.092 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.087788e-01 0.092 0 0
Vitamin B1 (thiamin) metabolism R-HSA-196819 8.087788e-01 0.092 0 0
Chylomicron assembly R-HSA-8963888 8.087788e-01 0.092 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.087788e-01 0.092 0 0
Transport of RCbl within the body R-HSA-9758890 8.087788e-01 0.092 0 0
Prostanoid ligand receptors R-HSA-391908 8.087788e-01 0.092 0 0
Interleukin-2 signaling R-HSA-9020558 8.087788e-01 0.092 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.098361e-01 0.092 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.114438e-01 0.091 0 0
Phenylalanine metabolism R-HSA-8964208 8.114438e-01 0.091 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.116214e-01 0.091 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.116214e-01 0.091 0 0
Signaling by ERBB2 R-HSA-1227986 8.122396e-01 0.090 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.125940e-01 0.090 0 0
Ribosome-associated quality control R-HSA-9948299 8.126593e-01 0.090 0 0
Nucleotide Excision Repair R-HSA-5696398 8.130090e-01 0.090 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.141765e-01 0.089 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.171968e-01 0.088 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.171968e-01 0.088 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.171968e-01 0.088 0 0
Signaling by Interleukins R-HSA-449147 8.183068e-01 0.087 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.207245e-01 0.086 0 0
Platelet homeostasis R-HSA-418346 8.211173e-01 0.086 0 0
Amyloid fiber formation R-HSA-977225 8.231704e-01 0.085 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.254406e-01 0.083 0 0
Host Interactions of HIV factors R-HSA-162909 8.270994e-01 0.082 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.276123e-01 0.082 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.276123e-01 0.082 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.276123e-01 0.082 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.292349e-01 0.081 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.301000e-01 0.081 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.301000e-01 0.081 0 0
Plasmalogen biosynthesis R-HSA-75896 8.301000e-01 0.081 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.301000e-01 0.081 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.301000e-01 0.081 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.301000e-01 0.081 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.301000e-01 0.081 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.301000e-01 0.081 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.301000e-01 0.081 0 0
Integration of provirus R-HSA-162592 8.301000e-01 0.081 0 0
Neuronal System R-HSA-112316 8.337752e-01 0.079 0 0
rRNA processing R-HSA-72312 8.345326e-01 0.079 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.383829e-01 0.077 0 0
Nuclear RNA decay R-HSA-9930044 8.383829e-01 0.077 0 0
MTOR signalling R-HSA-165159 8.406060e-01 0.075 0 0
G1/S Transition R-HSA-69206 8.411203e-01 0.075 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.422231e-01 0.075 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.425208e-01 0.074 0 0
FGFR2 alternative splicing R-HSA-6803529 8.425208e-01 0.074 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.425208e-01 0.074 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.425208e-01 0.074 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.425208e-01 0.074 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.454083e-01 0.073 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.454083e-01 0.073 0 0
Interleukin-1 family signaling R-HSA-446652 8.489146e-01 0.071 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.490450e-01 0.071 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.490450e-01 0.071 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.490450e-01 0.071 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.490450e-01 0.071 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.490450e-01 0.071 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.490450e-01 0.071 0 0
Repression of WNT target genes R-HSA-4641265 8.490450e-01 0.071 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.490450e-01 0.071 0 0
Regulation of IFNG signaling R-HSA-877312 8.490450e-01 0.071 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.490450e-01 0.071 0 0
Estrogen biosynthesis R-HSA-193144 8.490450e-01 0.071 0 0
Signaling by NOTCH4 R-HSA-9013694 8.494112e-01 0.071 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.504874e-01 0.070 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.504874e-01 0.070 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.504874e-01 0.070 0 0
Developmental Biology R-HSA-1266738 8.525801e-01 0.069 0 0
DNA Replication R-HSA-69306 8.548035e-01 0.068 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.562491e-01 0.067 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.562491e-01 0.067 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.562491e-01 0.067 0 0
Syndecan interactions R-HSA-3000170 8.562491e-01 0.067 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.589783e-01 0.066 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.589783e-01 0.066 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.597783e-01 0.066 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.611426e-01 0.065 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.614433e-01 0.065 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.614433e-01 0.065 0 0
DAP12 interactions R-HSA-2172127 8.614433e-01 0.065 0 0
RMTs methylate histone arginines R-HSA-3214858 8.614433e-01 0.065 0 0
eNOS activation R-HSA-203615 8.617938e-01 0.065 0 0
Signaling by NOTCH2 R-HSA-1980145 8.617938e-01 0.065 0 0
Nuclear import of Rev protein R-HSA-180746 8.617938e-01 0.065 0 0
Selenoamino acid metabolism R-HSA-2408522 8.627706e-01 0.064 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.640981e-01 0.063 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.648125e-01 0.063 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.658785e-01 0.063 0 0
Chylomicron remodeling R-HSA-8963901 8.658785e-01 0.063 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.658785e-01 0.063 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.658785e-01 0.063 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.658785e-01 0.063 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.658785e-01 0.063 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.658785e-01 0.063 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.658785e-01 0.063 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.658785e-01 0.063 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.658785e-01 0.063 0 0
Maturation of nucleoprotein R-HSA-9683610 8.658785e-01 0.063 0 0
Interleukin-6 signaling R-HSA-1059683 8.658785e-01 0.063 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.658785e-01 0.063 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.688751e-01 0.061 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.688751e-01 0.061 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.688751e-01 0.061 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.709586e-01 0.060 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.709586e-01 0.060 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.723417e-01 0.059 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.727074e-01 0.059 0 0
Ion homeostasis R-HSA-5578775 8.727074e-01 0.059 0 0
Kidney development R-HSA-9830369 8.760303e-01 0.057 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.771722e-01 0.057 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.771722e-01 0.057 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.788512e-01 0.056 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.799051e-01 0.056 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.799051e-01 0.056 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.799051e-01 0.056 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.799051e-01 0.056 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.804738e-01 0.055 0 0
Laminin interactions R-HSA-3000157 8.804738e-01 0.055 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.808358e-01 0.055 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.808358e-01 0.055 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.808358e-01 0.055 0 0
The activation of arylsulfatases R-HSA-1663150 8.808358e-01 0.055 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.808358e-01 0.055 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.808358e-01 0.055 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.808358e-01 0.055 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.808358e-01 0.055 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.808358e-01 0.055 0 0
Physiological factors R-HSA-5578768 8.808358e-01 0.055 0 0
Prolactin receptor signaling R-HSA-1170546 8.808358e-01 0.055 0 0
Malate-aspartate shuttle R-HSA-9856872 8.808358e-01 0.055 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.808358e-01 0.055 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.808358e-01 0.055 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.808358e-01 0.055 0 0
HDL assembly R-HSA-8963896 8.808358e-01 0.055 0 0
Zinc transporters R-HSA-435354 8.808358e-01 0.055 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.808358e-01 0.055 0 0
G1/S-Specific Transcription R-HSA-69205 8.821706e-01 0.054 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.821706e-01 0.054 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.821706e-01 0.054 0 0
Triglyceride catabolism R-HSA-163560 8.821706e-01 0.054 0 0
MHC class II antigen presentation R-HSA-2132295 8.828009e-01 0.054 0 0
Dual incision in TC-NER R-HSA-6782135 8.885428e-01 0.051 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.911173e-01 0.050 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.911173e-01 0.050 0 0
Suppression of phagosomal maturation R-HSA-9637687 8.911173e-01 0.050 0 0
Sphingolipid catabolism R-HSA-9845614 8.911173e-01 0.050 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.911173e-01 0.050 0 0
Signaling by FGFR2 R-HSA-5654738 8.934593e-01 0.049 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.941257e-01 0.049 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.941257e-01 0.049 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.941257e-01 0.049 0 0
Translesion synthesis by REV1 R-HSA-110312 8.941257e-01 0.049 0 0
Protein lipoylation R-HSA-9857492 8.941257e-01 0.049 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.941257e-01 0.049 0 0
Signaling by Activin R-HSA-1502540 8.941257e-01 0.049 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.941257e-01 0.049 0 0
Events associated with phagocytolytic activity of PMN cells R-HSA-8941413 8.941257e-01 0.049 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.941257e-01 0.049 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.941257e-01 0.049 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.941257e-01 0.049 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.941257e-01 0.049 0 0
Signaling by FGFR R-HSA-190236 8.951555e-01 0.048 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.958048e-01 0.048 0 0
GPER1 signaling R-HSA-9634597 8.961919e-01 0.048 0 0
L1CAM interactions R-HSA-373760 8.987244e-01 0.046 0 0
MET promotes cell motility R-HSA-8875878 8.998256e-01 0.046 0 0
DNA Repair R-HSA-73894 9.003079e-01 0.046 0 0
Co-inhibition by PD-1 R-HSA-389948 9.003870e-01 0.046 0 0
Signaling by BMP R-HSA-201451 9.008743e-01 0.045 0 0
Toll-like Receptor Cascades R-HSA-168898 9.030863e-01 0.044 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.035401e-01 0.044 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.059342e-01 0.043 0 0
Translesion synthesis by POLI R-HSA-5656121 9.059342e-01 0.043 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.059342e-01 0.043 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.059342e-01 0.043 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.059342e-01 0.043 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.059342e-01 0.043 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.059342e-01 0.043 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.059342e-01 0.043 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.059342e-01 0.043 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.059342e-01 0.043 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.059342e-01 0.043 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.059342e-01 0.043 0 0
Differentiation of T cells R-HSA-9945266 9.059342e-01 0.043 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.077268e-01 0.042 0 0
Platelet degranulation R-HSA-114608 9.078864e-01 0.042 0 0
Aquaporin-mediated transport R-HSA-445717 9.091069e-01 0.041 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.098101e-01 0.041 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.110170e-01 0.040 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.150586e-01 0.039 0 0
Diseases of Immune System R-HSA-5260271 9.150586e-01 0.039 0 0
Signaling by PDGF R-HSA-186797 9.151824e-01 0.038 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.152052e-01 0.038 0 0
Ca2+ pathway R-HSA-4086398 9.152052e-01 0.038 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.164263e-01 0.038 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.164263e-01 0.038 0 0
Translesion synthesis by POLK R-HSA-5655862 9.164263e-01 0.038 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.164263e-01 0.038 0 0
Glycine degradation R-HSA-6783984 9.164263e-01 0.038 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.164263e-01 0.038 0 0
Passive transport by Aquaporins R-HSA-432047 9.164263e-01 0.038 0 0
Synthesis of PG R-HSA-1483148 9.164263e-01 0.038 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.164263e-01 0.038 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.164263e-01 0.038 0 0
The phototransduction cascade R-HSA-2514856 9.169776e-01 0.038 0 0
mRNA Capping R-HSA-72086 9.179865e-01 0.037 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.197950e-01 0.036 0 0
HCMV Early Events R-HSA-9609690 9.211397e-01 0.036 0 0
Developmental Cell Lineages R-HSA-9734767 9.212522e-01 0.036 0 0
Maturation of spike protein R-HSA-9694548 9.218559e-01 0.035 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.254617e-01 0.034 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.254617e-01 0.034 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.254617e-01 0.034 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.254617e-01 0.034 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.254617e-01 0.034 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.256220e-01 0.034 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.256220e-01 0.034 0 0
Protein ubiquitination R-HSA-8852135 9.256220e-01 0.034 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.257486e-01 0.034 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.257486e-01 0.034 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.257486e-01 0.034 0 0
Catecholamine biosynthesis R-HSA-209905 9.257486e-01 0.034 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.257486e-01 0.034 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.257486e-01 0.034 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.257486e-01 0.034 0 0
Choline catabolism R-HSA-6798163 9.257486e-01 0.034 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 9.257486e-01 0.034 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 9.257486e-01 0.034 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.257486e-01 0.034 0 0
Gastrulation R-HSA-9758941 9.270937e-01 0.033 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.281519e-01 0.032 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.281519e-01 0.032 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.281519e-01 0.032 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.286834e-01 0.032 0 0
Cellular response to hypoxia R-HSA-1234174 9.313136e-01 0.031 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.322902e-01 0.030 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.322902e-01 0.030 0 0
Cargo concentration in the ER R-HSA-5694530 9.322902e-01 0.030 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.322902e-01 0.030 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.322902e-01 0.030 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.339786e-01 0.030 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.340315e-01 0.030 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.340315e-01 0.030 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.340315e-01 0.030 0 0
Apoptotic factor-mediated response R-HSA-111471 9.340315e-01 0.030 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.340315e-01 0.030 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.340315e-01 0.030 0 0
Tie2 Signaling R-HSA-210993 9.340315e-01 0.030 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.340315e-01 0.030 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.353571e-01 0.029 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.362423e-01 0.029 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.413909e-01 0.026 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.413909e-01 0.026 0 0
Translesion Synthesis by POLH R-HSA-110320 9.413909e-01 0.026 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.413909e-01 0.026 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.413909e-01 0.026 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.413909e-01 0.026 0 0
Other interleukin signaling R-HSA-449836 9.413909e-01 0.026 0 0
Diseases of hemostasis R-HSA-9671793 9.413909e-01 0.026 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.413909e-01 0.026 0 0
HDL remodeling R-HSA-8964058 9.413909e-01 0.026 0 0
Maturation of nucleoprotein R-HSA-9694631 9.413909e-01 0.026 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.413909e-01 0.026 0 0
STING mediated induction of host immune responses R-HSA-1834941 9.413909e-01 0.026 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.413909e-01 0.026 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.434614e-01 0.025 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.442091e-01 0.025 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.446311e-01 0.025 0 0
Neurotransmitter release cycle R-HSA-112310 9.462576e-01 0.024 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.479297e-01 0.023 0 0
Formation of definitive endoderm R-HSA-9823730 9.479297e-01 0.023 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.479297e-01 0.023 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.479297e-01 0.023 0 0
Pregnenolone biosynthesis R-HSA-196108 9.479297e-01 0.023 0 0
Protein hydroxylation R-HSA-9629569 9.479297e-01 0.023 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.479297e-01 0.023 0 0
Glycogen synthesis R-HSA-3322077 9.479297e-01 0.023 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.489411e-01 0.023 0 0
Transmission across Chemical Synapses R-HSA-112315 9.490098e-01 0.023 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.493917e-01 0.023 0 0
Heme degradation R-HSA-189483 9.493917e-01 0.023 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.521872e-01 0.021 0 0
Interleukin-1 signaling R-HSA-9020702 9.526288e-01 0.021 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.537393e-01 0.021 0 0
G-protein activation R-HSA-202040 9.537393e-01 0.021 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.537393e-01 0.021 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.537393e-01 0.021 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.537393e-01 0.021 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.537393e-01 0.021 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 9.537393e-01 0.021 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 9.537393e-01 0.021 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.537393e-01 0.021 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.537393e-01 0.021 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.541128e-01 0.020 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.541128e-01 0.020 0 0
Mitophagy R-HSA-5205647 9.541128e-01 0.020 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.545167e-01 0.020 0 0
Extension of Telomeres R-HSA-180786 9.553899e-01 0.020 0 0
Triglyceride metabolism R-HSA-8979227 9.553899e-01 0.020 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.555957e-01 0.020 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.555957e-01 0.020 0 0
Signaling by Insulin receptor R-HSA-74752 9.558549e-01 0.020 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.570910e-01 0.019 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.570910e-01 0.019 0 0
Recycling pathway of L1 R-HSA-437239 9.570910e-01 0.019 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.578425e-01 0.019 0 0
Parasite infection R-HSA-9664407 9.578425e-01 0.019 0 0
Leishmania phagocytosis R-HSA-9664417 9.578425e-01 0.019 0 0
Regulation of Apoptosis R-HSA-169911 9.584108e-01 0.018 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.584108e-01 0.018 0 0
PERK regulates gene expression R-HSA-381042 9.584108e-01 0.018 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.589010e-01 0.018 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.589010e-01 0.018 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.589010e-01 0.018 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 9.589010e-01 0.018 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.589010e-01 0.018 0 0
Serine metabolism R-HSA-977347 9.589010e-01 0.018 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.589010e-01 0.018 0 0
Signaling by PDGFR in disease R-HSA-9671555 9.589010e-01 0.018 0 0
HCMV Infection R-HSA-9609646 9.590102e-01 0.018 0 0
Cardiac conduction R-HSA-5576891 9.592857e-01 0.018 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.601007e-01 0.018 0 0
Mitochondrial protein degradation R-HSA-9837999 9.613663e-01 0.017 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.620029e-01 0.017 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.620029e-01 0.017 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.620029e-01 0.017 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.623213e-01 0.017 0 0
RNA Polymerase III Transcription R-HSA-74158 9.623213e-01 0.017 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.634871e-01 0.016 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.634871e-01 0.016 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.634871e-01 0.016 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.634871e-01 0.016 0 0
Signaling by KIT in disease R-HSA-9669938 9.634871e-01 0.016 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.634871e-01 0.016 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.634871e-01 0.016 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.634871e-01 0.016 0 0
Ethanol oxidation R-HSA-71384 9.634871e-01 0.016 0 0
Cellular hexose transport R-HSA-189200 9.634871e-01 0.016 0 0
LDL clearance R-HSA-8964038 9.634871e-01 0.016 0 0
Gap junction trafficking and regulation R-HSA-157858 9.640089e-01 0.016 0 0
Neutrophil degranulation R-HSA-6798695 9.641276e-01 0.016 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.642979e-01 0.016 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.649570e-01 0.015 0 0
tRNA processing in the nucleus R-HSA-6784531 9.649570e-01 0.015 0 0
Degradation of AXIN R-HSA-4641257 9.658772e-01 0.015 0 0
Voltage gated Potassium channels R-HSA-1296072 9.658772e-01 0.015 0 0
Degradation of DVL R-HSA-4641258 9.658772e-01 0.015 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.658772e-01 0.015 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.675072e-01 0.014 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.675616e-01 0.014 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.675616e-01 0.014 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.675616e-01 0.014 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.675616e-01 0.014 0 0
Formation of the ureteric bud R-HSA-9830674 9.675616e-01 0.014 0 0
Biosynthesis of maresins R-HSA-9018682 9.675616e-01 0.014 0 0
Potassium Channels R-HSA-1296071 9.684711e-01 0.014 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.691090e-01 0.014 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.698659e-01 0.013 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.698659e-01 0.013 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.711817e-01 0.013 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.711817e-01 0.013 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.711817e-01 0.013 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.711817e-01 0.013 0 0
Interleukin-6 family signaling R-HSA-6783589 9.711817e-01 0.013 0 0
Stimuli-sensing channels R-HSA-2672351 9.716995e-01 0.012 0 0
Pentose phosphate pathway R-HSA-71336 9.720447e-01 0.012 0 0
Stabilization of p53 R-HSA-69541 9.720447e-01 0.012 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.720447e-01 0.012 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.724445e-01 0.012 0 0
Orc1 removal from chromatin R-HSA-68949 9.724445e-01 0.012 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.724445e-01 0.012 0 0
Metabolism of RNA R-HSA-8953854 9.741519e-01 0.011 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.743979e-01 0.011 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.743979e-01 0.011 0 0
Hyaluronan degradation R-HSA-2160916 9.743979e-01 0.011 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.743979e-01 0.011 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.743979e-01 0.011 0 0
Retinoid cycle disease events R-HSA-2453864 9.743979e-01 0.011 0 0
Diseases of the neuronal system R-HSA-9675143 9.743979e-01 0.011 0 0
Diseases associated with visual transduction R-HSA-2474795 9.743979e-01 0.011 0 0
Leishmania infection R-HSA-9658195 9.745516e-01 0.011 0 0
Parasitic Infection Pathways R-HSA-9824443 9.745516e-01 0.011 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.747101e-01 0.011 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.747101e-01 0.011 0 0
Glycogen metabolism R-HSA-8982491 9.747101e-01 0.011 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.747618e-01 0.011 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.748128e-01 0.011 0 0
Downstream TCR signaling R-HSA-202424 9.756957e-01 0.011 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.771290e-01 0.010 0 0
MET activates PTK2 signaling R-HSA-8874081 9.772554e-01 0.010 0 0
Signaling by MET R-HSA-6806834 9.776397e-01 0.010 0 0
G alpha (s) signalling events R-HSA-418555 9.779166e-01 0.010 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.781276e-01 0.010 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.789816e-01 0.009 0 0
IRE1alpha activates chaperones R-HSA-381070 9.790310e-01 0.009 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.793232e-01 0.009 0 0
Translation of Structural Proteins R-HSA-9683701 9.793232e-01 0.009 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.797941e-01 0.009 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.797941e-01 0.009 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.797941e-01 0.009 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.797941e-01 0.009 0 0
Triglyceride biosynthesis R-HSA-75109 9.797941e-01 0.009 0 0
Insulin processing R-HSA-264876 9.797941e-01 0.009 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.797941e-01 0.009 0 0
Activation of GABAB receptors R-HSA-991365 9.813126e-01 0.008 0 0
GABA B receptor activation R-HSA-977444 9.813126e-01 0.008 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.819365e-01 0.008 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.820496e-01 0.008 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.820496e-01 0.008 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.820496e-01 0.008 0 0
Pyroptosis R-HSA-5620971 9.820496e-01 0.008 0 0
Synthesis of PA R-HSA-1483166 9.824873e-01 0.008 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.831157e-01 0.007 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.831157e-01 0.007 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.835033e-01 0.007 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.840231e-01 0.007 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.840534e-01 0.007 0 0
Thyroxine biosynthesis R-HSA-209968 9.840534e-01 0.007 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.840534e-01 0.007 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.840534e-01 0.007 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.840534e-01 0.007 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.840534e-01 0.007 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.846043e-01 0.007 0 0
Interferon alpha/beta signaling R-HSA-909733 9.846043e-01 0.007 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.847493e-01 0.007 0 0
Gap junction trafficking R-HSA-190828 9.847493e-01 0.007 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.854294e-01 0.006 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.858337e-01 0.006 0 0
Mucopolysaccharidoses R-HSA-2206281 9.858337e-01 0.006 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.860120e-01 0.006 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.862287e-01 0.006 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.862287e-01 0.006 0 0
Synthesis of DNA R-HSA-69239 9.864982e-01 0.006 0 0
GABA receptor activation R-HSA-977443 9.867165e-01 0.006 0 0
RAB geranylgeranylation R-HSA-8873719 9.867165e-01 0.006 0 0
Glutathione conjugation R-HSA-156590 9.867165e-01 0.006 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.867165e-01 0.006 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.867165e-01 0.006 1 1
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.874153e-01 0.006 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.874153e-01 0.006 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.874153e-01 0.006 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.875679e-01 0.005 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.875679e-01 0.005 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.881792e-01 0.005 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.882222e-01 0.005 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.882293e-01 0.005 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.887799e-01 0.005 0 0
Synthesis of PC R-HSA-1483191 9.887799e-01 0.005 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.888204e-01 0.005 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.888204e-01 0.005 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.889708e-01 0.005 0 0
Adaptive Immune System R-HSA-1280218 9.898752e-01 0.004 0 0
Intraflagellar transport R-HSA-5620924 9.898763e-01 0.004 0 0
Metal ion SLC transporters R-HSA-425410 9.898763e-01 0.004 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.899371e-01 0.004 0 0
Complex I biogenesis R-HSA-6799198 9.899550e-01 0.004 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.900686e-01 0.004 0 0
Translation of Structural Proteins R-HSA-9694635 9.900969e-01 0.004 0 0
GPCR downstream signalling R-HSA-388396 9.903338e-01 0.004 0 0
Protein localization R-HSA-9609507 9.905658e-01 0.004 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.908678e-01 0.004 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.908678e-01 0.004 0 0
Cholesterol biosynthesis R-HSA-191273 9.909237e-01 0.004 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.911776e-01 0.004 0 0
CS/DS degradation R-HSA-2024101 9.911776e-01 0.004 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.911776e-01 0.004 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.917642e-01 0.004 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.921628e-01 0.003 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.921628e-01 0.003 0 0
Hyaluronan metabolism R-HSA-2142845 9.921628e-01 0.003 0 0
RA biosynthesis pathway R-HSA-5365859 9.921628e-01 0.003 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.921628e-01 0.003 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.921628e-01 0.003 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.925744e-01 0.003 0 0
HCMV Late Events R-HSA-9610379 9.927324e-01 0.003 0 0
Protein folding R-HSA-391251 9.927793e-01 0.003 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.930380e-01 0.003 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.930380e-01 0.003 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.930380e-01 0.003 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.930380e-01 0.003 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.930380e-01 0.003 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.931096e-01 0.003 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.931961e-01 0.003 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.934260e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.938156e-01 0.003 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.938156e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.938892e-01 0.003 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.941586e-01 0.003 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.945063e-01 0.002 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.945063e-01 0.002 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.945063e-01 0.002 0 0
Lysine catabolism R-HSA-71064 9.945063e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.945063e-01 0.002 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.945645e-01 0.002 0 0
COPII-mediated vesicle transport R-HSA-204005 9.948222e-01 0.002 0 0
Hemostasis R-HSA-109582 9.949684e-01 0.002 0 0
Paracetamol ADME R-HSA-9753281 9.951035e-01 0.002 0 0
G alpha (z) signalling events R-HSA-418597 9.951035e-01 0.002 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.955899e-01 0.002 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.955899e-01 0.002 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.956651e-01 0.002 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.956651e-01 0.002 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.959947e-01 0.002 0 0
Regulation of CDH1 Function R-HSA-9764561 9.960288e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.961493e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.964757e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.965259e-01 0.002 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.965406e-01 0.002 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.965795e-01 0.001 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.965795e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.965795e-01 0.001 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.965795e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.966242e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.967545e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.968008e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.968057e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.969617e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.972844e-01 0.001 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.973011e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.973938e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.974800e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.976106e-01 0.001 0 0
PCP/CE pathway R-HSA-4086400 9.976106e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.978397e-01 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.978397e-01 0.001 0 0
Proteasome assembly R-HSA-9907900 9.978706e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.978706e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.978706e-01 0.001 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.978778e-01 0.001 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.981085e-01 0.001 0 0
Somitogenesis R-HSA-9824272 9.981085e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.981085e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.983199e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.985077e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.986215e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.986215e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.986745e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.987610e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.988226e-01 0.001 0 0
Degradation of CDH1 R-HSA-9766229 9.988226e-01 0.001 0 0
Viral Infection Pathways R-HSA-9824446 9.988931e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.989542e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.989733e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.989995e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.989995e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.990161e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.990711e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.990711e-01 0.000 0 0
Neddylation R-HSA-8951664 9.990746e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.991012e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.991012e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.991012e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.991012e-01 0.000 0 0
Potential therapeutics for SARS R-HSA-9679191 9.991733e-01 0.000 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.991750e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.991926e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.992672e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.992748e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.993492e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.994219e-01 0.000 0 0
Digestion R-HSA-8935690 9.994866e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.995200e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.995440e-01 0.000 0 0
tRNA processing R-HSA-72306 9.995596e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.995770e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.995770e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.996203e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.996203e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.996403e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.996403e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.996805e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.996805e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.997056e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.997489e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.997598e-01 0.000 0 0
SARS-CoV Infections R-HSA-9679506 9.997706e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.997762e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.997831e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.998012e-01 0.000 0 0
Ion transport by P-type ATPases R-HSA-936837 9.998012e-01 0.000 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.998225e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.998235e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998326e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.998408e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998559e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.998763e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.998853e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998997e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.999055e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999085e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999134e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.999223e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999231e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999300e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999369e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.999382e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.999461e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999573e-01 0.000 0 0
Immune System R-HSA-168256 9.999591e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999669e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999669e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999680e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999736e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999736e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999743e-01 0.000 0 0
Translation R-HSA-72766 9.999769e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999789e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999837e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999842e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999885e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999919e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999932e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999951e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999954e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999961e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999974e-01 0.000 1 0
Peptide ligand-binding receptors R-HSA-375276 9.999976e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999978e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999979e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999981e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999985e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999985e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999993e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999995e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999998e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999998e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999999e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999999e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 9.547918e-15 14.020 0 0
Cell Cycle, Mitotic R-HSA-69278 2.109424e-14 13.676 0 0
Cellular responses to stress R-HSA-2262752 3.341771e-14 13.476 0 0
Cell Cycle Checkpoints R-HSA-69620 5.961898e-14 13.225 0 0
M Phase R-HSA-68886 2.406964e-13 12.619 0 0
Axon guidance R-HSA-422475 9.539036e-13 12.020 0 0
Nervous system development R-HSA-9675108 1.274425e-12 11.895 0 0
Cellular response to heat stress R-HSA-3371556 5.378031e-12 11.269 0 0
Apoptotic execution phase R-HSA-75153 8.521184e-12 11.070 0 0
Attenuation phase R-HSA-3371568 1.170641e-11 10.932 0 0
HSF1-dependent transactivation R-HSA-3371571 1.277423e-11 10.894 0 0
Signaling by ROBO receptors R-HSA-376176 1.476086e-11 10.831 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.158830e-10 9.936 0 0
Apoptosis R-HSA-109581 2.442740e-10 9.612 0 0
HSF1 activation R-HSA-3371511 3.314838e-10 9.480 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.221462e-10 9.282 0 0
G2/M Checkpoints R-HSA-69481 8.987822e-10 9.046 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.163839e-09 8.934 0 0
Peptide chain elongation R-HSA-156902 1.508038e-09 8.822 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.597262e-09 8.585 0 0
Mitotic Prometaphase R-HSA-68877 2.852286e-09 8.545 0 0
Signal Transduction R-HSA-162582 4.626085e-09 8.335 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.839055e-09 8.165 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.839055e-09 8.165 0 0
Separation of Sister Chromatids R-HSA-2467813 7.471218e-09 8.127 0 0
Programmed Cell Death R-HSA-5357801 8.115407e-09 8.091 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.255634e-09 8.083 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.027924e-08 7.988 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.082702e-08 7.965 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.555763e-08 7.808 0 0
Nucleosome assembly R-HSA-774815 1.555763e-08 7.808 0 0
Mitotic Anaphase R-HSA-68882 1.603940e-08 7.795 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.884344e-08 7.725 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.884344e-08 7.725 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.843846e-08 7.734 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.816694e-08 7.550 0 0
Ribosome-associated quality control R-HSA-9948299 3.063431e-08 7.514 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.144004e-08 7.383 0 0
Cellular Senescence R-HSA-2559583 4.189857e-08 7.378 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.327165e-08 7.199 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.660638e-08 7.176 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.856389e-08 7.164 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.294617e-07 6.888 0 0
Eukaryotic Translation Termination R-HSA-72764 1.294617e-07 6.888 0 0
Selenocysteine synthesis R-HSA-2408557 1.427234e-07 6.846 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.492555e-07 6.826 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.566305e-07 6.805 0 0
Metabolism of RNA R-HSA-8953854 1.759141e-07 6.755 0 0
G2/M Transition R-HSA-69275 2.413431e-07 6.617 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.714451e-07 6.566 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.166595e-07 6.499 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.149458e-07 6.382 0 0
DNA Double Strand Break Response R-HSA-5693606 5.182703e-07 6.285 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.386991e-07 6.269 0 0
Viral mRNA Translation R-HSA-192823 6.133872e-07 6.212 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.952540e-07 6.158 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.598639e-07 6.066 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.075645e-06 5.968 0 0
Influenza Infection R-HSA-168255 1.230078e-06 5.910 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.302443e-06 5.885 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.302443e-06 5.885 0 0
Deubiquitination R-HSA-5688426 1.887525e-06 5.724 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.902719e-06 5.721 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.943678e-06 5.711 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.216036e-06 5.654 0 0
Aggrephagy R-HSA-9646399 3.061827e-06 5.514 0 0
Cell-Cell communication R-HSA-1500931 3.107066e-06 5.508 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.329911e-06 5.478 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.332677e-06 5.477 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.796380e-06 5.421 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.999858e-06 5.398 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.111804e-06 5.386 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.262866e-06 5.370 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.459276e-06 5.351 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.688985e-06 5.329 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.913907e-06 5.228 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.188292e-06 5.208 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.635274e-06 5.064 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 8.991163e-06 5.046 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.077990e-05 4.967 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.144770e-05 4.941 0 0
Kinesins R-HSA-983189 1.257371e-05 4.901 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.257371e-05 4.901 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.403972e-05 4.853 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.472099e-05 4.832 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.496712e-05 4.825 0 0
Ub-specific processing proteases R-HSA-5689880 1.499218e-05 4.824 0 0
Cell junction organization R-HSA-446728 1.811532e-05 4.742 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.029408e-05 4.693 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.501174e-05 4.602 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.377195e-05 4.624 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.377195e-05 4.624 0 0
Cellular response to starvation R-HSA-9711097 2.396133e-05 4.620 0 0
Adherens junctions interactions R-HSA-418990 2.577537e-05 4.589 0 0
Meiotic synapsis R-HSA-1221632 2.844359e-05 4.546 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.299084e-05 4.482 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.549346e-05 4.450 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.603997e-05 4.443 0 0
Mitotic Prophase R-HSA-68875 3.787634e-05 4.422 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.904700e-05 4.408 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.914850e-05 4.407 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.267769e-05 4.370 0 0
Membrane Trafficking R-HSA-199991 4.059317e-05 4.392 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.409246e-05 4.356 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.600310e-05 4.337 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.202581e-05 4.284 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.420953e-05 4.266 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.750365e-05 4.240 0 0
Regulation of CDH1 Function R-HSA-9764561 6.515160e-05 4.186 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.190030e-05 4.143 0 0
Homology Directed Repair R-HSA-5693538 6.823679e-05 4.166 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.220605e-05 4.141 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 7.253827e-05 4.139 0 0
Protein ubiquitination R-HSA-8852135 7.453054e-05 4.128 0 0
Interleukin-12 signaling R-HSA-9020591 8.821257e-05 4.054 0 0
TCF dependent signaling in response to WNT R-HSA-201681 9.373485e-05 4.028 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.347036e-04 3.871 0 0
Cell-cell junction organization R-HSA-421270 1.437978e-04 3.842 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.661933e-04 3.779 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.694734e-04 3.771 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.707412e-04 3.768 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.763969e-04 3.754 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.909678e-04 3.719 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.980366e-04 3.703 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.980366e-04 3.703 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.962985e-04 3.707 0 0
Signaling by NOTCH R-HSA-157118 1.952154e-04 3.709 0 0
rRNA processing R-HSA-72312 1.839577e-04 3.735 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.909678e-04 3.719 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.011585e-04 3.696 0 0
Packaging Of Telomere Ends R-HSA-171306 2.060053e-04 3.686 0 0
Chromatin modifying enzymes R-HSA-3247509 2.180960e-04 3.661 0 0
Developmental Biology R-HSA-1266738 2.210409e-04 3.656 0 0
Chromosome Maintenance R-HSA-73886 2.255998e-04 3.647 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.267293e-04 3.644 0 0
Recycling pathway of L1 R-HSA-437239 2.496866e-04 3.603 0 0
Selective autophagy R-HSA-9663891 2.543220e-04 3.595 0 0
Diseases of programmed cell death R-HSA-9645723 2.543220e-04 3.595 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.780963e-04 3.556 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.803472e-04 3.552 0 0
RNA Polymerase I Transcription R-HSA-73864 3.164555e-04 3.500 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.241267e-04 3.489 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.241267e-04 3.489 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.277946e-04 3.484 0 0
Defective pyroptosis R-HSA-9710421 3.430316e-04 3.465 0 0
DNA methylation R-HSA-5334118 3.473962e-04 3.459 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.473962e-04 3.459 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.608803e-04 3.443 0 0
Signaling by ALK in cancer R-HSA-9700206 3.608803e-04 3.443 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.781620e-04 3.422 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.781620e-04 3.422 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.852160e-04 3.414 0 0
HDACs deacetylate histones R-HSA-3214815 3.808874e-04 3.419 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.040500e-04 3.394 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.875533e-04 3.412 0 0
Selenoamino acid metabolism R-HSA-2408522 4.169148e-04 3.380 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.377811e-04 3.359 0 0
Signaling by NOTCH4 R-HSA-9013694 4.398796e-04 3.357 0 0
Josephin domain DUBs R-HSA-5689877 4.584976e-04 3.339 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.708023e-04 3.327 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.980790e-04 3.303 0 0
Centrosome maturation R-HSA-380287 5.101699e-04 3.292 0 0
Interleukin-12 family signaling R-HSA-447115 5.341621e-04 3.272 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.119195e-04 3.213 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.119195e-04 3.213 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.119195e-04 3.213 0 0
HCMV Early Events R-HSA-9609690 6.113062e-04 3.214 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.900003e-04 3.229 0 0
Signaling by RAS mutants R-HSA-6802949 6.119195e-04 3.213 0 0
DNA Replication R-HSA-69306 5.646907e-04 3.248 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.889729e-04 3.230 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.054054e-04 3.218 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.635538e-04 3.249 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.303281e-04 3.200 0 0
MAPK family signaling cascades R-HSA-5683057 6.331180e-04 3.199 0 0
Regulation of PTEN localization R-HSA-8948747 6.652461e-04 3.177 0 0
Hedgehog 'off' state R-HSA-5610787 6.842321e-04 3.165 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.898230e-04 3.161 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.013435e-04 3.154 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.081144e-04 3.150 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.097038e-04 3.149 0 0
Chromatin organization R-HSA-4839726 7.170353e-04 3.144 0 0
Autophagy R-HSA-9612973 7.521016e-04 3.124 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.936026e-04 3.100 0 0
Meiosis R-HSA-1500620 8.455765e-04 3.073 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.663251e-04 3.062 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 9.098320e-04 3.041 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 9.379443e-04 3.028 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.422324e-04 3.026 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.081810e-03 2.966 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.026952e-03 2.988 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.081810e-03 2.966 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.081810e-03 2.966 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.081810e-03 2.966 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.136605e-03 2.944 0 0
Viral Infection Pathways R-HSA-9824446 1.140547e-03 2.943 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.189743e-03 2.925 0 0
Late endosomal microautophagy R-HSA-9615710 1.203855e-03 2.919 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.246682e-03 2.904 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.288891e-03 2.890 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.339998e-03 2.873 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.339998e-03 2.873 0 0
HATs acetylate histones R-HSA-3214847 1.340475e-03 2.873 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.418540e-03 2.848 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.425280e-03 2.846 0 0
Meiotic recombination R-HSA-912446 1.453531e-03 2.838 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.512578e-03 2.820 0 0
Co-inhibition by PD-1 R-HSA-389948 1.544241e-03 2.811 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.617348e-03 2.791 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.032834e-03 2.692 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.032834e-03 2.692 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.787090e-03 2.748 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.939793e-03 2.712 0 0
Signaling by Hedgehog R-HSA-5358351 1.839469e-03 2.735 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.116194e-03 2.674 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.256470e-03 2.647 0 0
Death Receptor Signaling R-HSA-73887 2.290812e-03 2.640 0 0
Translation initiation complex formation R-HSA-72649 2.318221e-03 2.635 0 0
PKR-mediated signaling R-HSA-9833482 2.372891e-03 2.625 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.379285e-03 2.624 0 0
Cleavage of the damaged purine R-HSA-110331 2.379285e-03 2.624 0 0
Macroautophagy R-HSA-1632852 2.411165e-03 2.618 0 0
Signaling by WNT R-HSA-195721 2.428331e-03 2.615 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.484982e-03 2.605 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.484982e-03 2.605 0 0
S Phase R-HSA-69242 2.564860e-03 2.591 0 0
L1CAM interactions R-HSA-373760 2.570597e-03 2.590 0 0
Amyloid fiber formation R-HSA-977225 2.678837e-03 2.572 0 0
Signaling by NOTCH3 R-HSA-9012852 2.687336e-03 2.571 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.725272e-03 2.565 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.751805e-03 2.560 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.756164e-03 2.560 0 0
Post NMDA receptor activation events R-HSA-438064 2.763575e-03 2.559 0 0
Host Interactions of HIV factors R-HSA-162909 2.796834e-03 2.553 0 0
Depurination R-HSA-73927 2.844962e-03 2.546 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.935068e-03 2.532 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.949130e-03 2.530 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.560327e-03 2.449 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.245878e-03 2.489 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.103674e-03 2.508 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.061868e-03 2.514 0 0
UCH proteinases R-HSA-5689603 3.282082e-03 2.484 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.560327e-03 2.449 0 0
Signaling by VEGF R-HSA-194138 3.364865e-03 2.473 0 0
NRAGE signals death through JNK R-HSA-193648 3.103674e-03 2.508 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.372730e-03 2.472 0 0
HCMV Infection R-HSA-9609646 3.752405e-03 2.426 0 0
Rap1 signalling R-HSA-392517 3.797036e-03 2.421 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.801203e-03 2.420 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.864460e-03 2.413 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.876498e-03 2.412 0 0
p75NTR signals via NF-kB R-HSA-193639 3.876498e-03 2.412 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.876498e-03 2.412 0 0
Muscle contraction R-HSA-397014 3.975386e-03 2.401 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.997950e-03 2.398 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.035337e-03 2.394 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.095885e-03 2.388 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.162105e-03 2.381 0 0
Orc1 removal from chromatin R-HSA-68949 4.343380e-03 2.362 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.364544e-03 2.360 0 0
Activation of BH3-only proteins R-HSA-114452 4.659400e-03 2.332 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.700928e-03 2.328 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.700928e-03 2.328 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.788933e-03 2.320 0 0
NF-kB is activated and signals survival R-HSA-209560 4.947806e-03 2.306 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.947806e-03 2.306 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.947806e-03 2.306 0 0
Negative regulation of FLT3 R-HSA-9706369 5.091630e-03 2.293 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.113365e-03 2.291 0 0
MAP2K and MAPK activation R-HSA-5674135 5.499288e-03 2.260 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.954907e-03 2.225 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.695988e-03 2.174 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.695988e-03 2.174 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.695988e-03 2.174 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.695988e-03 2.174 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.695988e-03 2.174 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.046355e-03 2.219 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.046355e-03 2.219 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.046355e-03 2.219 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 5.604501e-03 2.251 0 0
mRNA Splicing R-HSA-72172 6.561665e-03 2.183 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.572600e-03 2.182 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.695988e-03 2.174 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 5.954907e-03 2.225 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.287267e-03 2.202 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.401737e-03 2.194 0 0
Depyrimidination R-HSA-73928 6.401737e-03 2.194 0 0
Gene Silencing by RNA R-HSA-211000 6.917112e-03 2.160 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.998533e-03 2.155 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.998533e-03 2.155 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.998533e-03 2.155 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.493549e-03 2.125 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.493549e-03 2.125 0 0
Semaphorin interactions R-HSA-373755 7.737825e-03 2.111 0 0
DNA Repair R-HSA-73894 7.866935e-03 2.104 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.893945e-03 2.103 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.924673e-03 2.101 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 8.472447e-03 2.072 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.472447e-03 2.072 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.804792e-03 2.055 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.853308e-03 2.053 0 0
Hedgehog 'on' state R-HSA-5632684 8.862508e-03 2.052 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 9.023864e-03 2.045 0 0
TCR signaling R-HSA-202403 9.035234e-03 2.044 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.187058e-03 2.037 0 0
Striated Muscle Contraction R-HSA-390522 9.355347e-03 2.029 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.455793e-03 2.024 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 9.794756e-03 2.009 0 0
Maturation of protein E R-HSA-9694493 9.794756e-03 2.009 0 0
Maturation of protein E R-HSA-9683683 9.794756e-03 2.009 0 0
Regulation of KIT signaling R-HSA-1433559 1.146710e-02 1.941 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.095754e-02 1.960 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.123585e-02 1.949 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.123585e-02 1.949 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.038365e-02 1.984 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.175794e-02 1.930 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.175794e-02 1.930 0 0
EPH-Ephrin signaling R-HSA-2682334 1.065494e-02 1.972 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.146710e-02 1.941 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.204919e-02 1.919 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.146710e-02 1.941 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.123585e-02 1.949 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.049770e-02 1.979 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.146710e-02 1.941 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.204919e-02 1.919 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.096263e-02 1.960 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.084080e-02 1.965 0 0
ESR-mediated signaling R-HSA-8939211 1.150100e-02 1.939 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.046237e-02 1.980 0 0
Regulation of TP53 Activity R-HSA-5633007 1.149040e-02 1.940 0 0
PTEN Regulation R-HSA-6807070 1.240893e-02 1.906 0 0
Glycolysis R-HSA-70171 1.244786e-02 1.905 0 0
Vesicle-mediated transport R-HSA-5653656 1.259079e-02 1.900 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.264652e-02 1.898 0 0
Regulation of Apoptosis R-HSA-169911 1.275950e-02 1.894 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.279804e-02 1.893 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.293584e-02 1.888 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.293584e-02 1.888 0 0
Translesion Synthesis by POLH R-HSA-110320 1.293584e-02 1.888 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.326543e-02 1.877 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.340753e-02 1.873 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.382469e-02 1.859 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.422250e-02 1.847 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.458267e-02 1.836 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.458267e-02 1.836 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.458267e-02 1.836 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.458267e-02 1.836 0 0
Translesion synthesis by REV1 R-HSA-110312 1.458267e-02 1.836 0 0
Calmodulin induced events R-HSA-111933 1.477556e-02 1.830 0 0
CaM pathway R-HSA-111997 1.477556e-02 1.830 0 0
FLT3 signaling in disease R-HSA-9682385 1.477556e-02 1.830 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.477754e-02 1.830 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.492472e-02 1.826 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.492472e-02 1.826 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.503089e-02 1.823 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.553999e-02 1.809 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.554921e-02 1.808 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.554921e-02 1.808 0 0
Base Excision Repair R-HSA-73884 1.574424e-02 1.803 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.579102e-02 1.802 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.580352e-02 1.801 0 0
DNA Damage Bypass R-HSA-73893 1.641492e-02 1.785 0 0
Gap junction trafficking and regulation R-HSA-157858 1.641492e-02 1.785 0 0
Degradation of CDH1 R-HSA-9766229 1.641492e-02 1.785 0 0
MHC class II antigen presentation R-HSA-2132295 1.654973e-02 1.781 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.673386e-02 1.776 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.673386e-02 1.776 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.681763e-02 1.774 0 0
Degradation of AXIN R-HSA-4641257 1.701994e-02 1.769 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.701994e-02 1.769 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.828873e-02 1.738 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.828873e-02 1.738 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.828873e-02 1.738 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.828873e-02 1.738 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.828873e-02 1.738 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.828873e-02 1.738 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.041794e-02 1.690 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.041794e-02 1.690 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.041794e-02 1.690 0 0
Translesion synthesis by POLI R-HSA-5656121 1.824250e-02 1.739 0 0
Translesion synthesis by POLK R-HSA-5655862 2.248550e-02 1.648 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.889357e-02 1.724 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.224931e-02 1.653 0 0
Neutrophil degranulation R-HSA-6798695 2.032208e-02 1.692 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.248550e-02 1.648 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.034259e-02 1.692 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.034259e-02 1.692 0 0
Gap junction trafficking R-HSA-190828 2.034259e-02 1.692 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.075347e-02 1.683 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.037578e-02 1.691 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.824250e-02 1.739 0 0
Stabilization of p53 R-HSA-69541 2.224931e-02 1.653 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.037870e-02 1.691 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.224931e-02 1.653 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.868188e-02 1.729 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.909518e-02 1.719 0 0
Activation of RAC1 R-HSA-428540 2.022028e-02 1.694 0 0
Sensory processing of sound R-HSA-9659379 1.992396e-02 1.701 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.909518e-02 1.719 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.283880e-02 1.641 0 0
DAG and IP3 signaling R-HSA-1489509 2.295053e-02 1.639 0 0
Synthesis of DNA R-HSA-69239 2.386507e-02 1.622 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.412561e-02 1.618 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.449933e-02 1.611 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.449933e-02 1.611 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.449933e-02 1.611 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.449933e-02 1.611 0 0
HIV Infection R-HSA-162906 2.486182e-02 1.604 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.526115e-02 1.598 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.526115e-02 1.598 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.526115e-02 1.598 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.526115e-02 1.598 0 0
Signaling by ERBB2 R-HSA-1227986 2.566801e-02 1.591 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.566801e-02 1.591 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.566801e-02 1.591 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.566801e-02 1.591 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.566801e-02 1.591 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.566801e-02 1.591 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.573739e-02 1.589 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.573739e-02 1.589 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.573739e-02 1.589 0 0
Translation R-HSA-72766 2.575295e-02 1.589 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.582015e-02 1.588 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.588998e-02 1.587 0 0
Smooth Muscle Contraction R-HSA-445355 2.588998e-02 1.587 0 0
Signaling by Hippo R-HSA-2028269 2.734641e-02 1.563 0 0
Signaling by NOTCH2 R-HSA-1980145 2.761421e-02 1.559 0 0
RAF activation R-HSA-5673000 2.761421e-02 1.559 0 0
Nuclear import of Rev protein R-HSA-180746 2.761421e-02 1.559 0 0
Gap junction assembly R-HSA-190861 2.761421e-02 1.559 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.761421e-02 1.559 0 0
Type I hemidesmosome assembly R-HSA-446107 2.763647e-02 1.559 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.763647e-02 1.559 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.763647e-02 1.559 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.763647e-02 1.559 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.763647e-02 1.559 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.800743e-02 1.553 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.836610e-02 1.547 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.855484e-02 1.544 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.855484e-02 1.544 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.878041e-02 1.541 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.878041e-02 1.541 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.878041e-02 1.541 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.934804e-02 1.532 0 0
Signaling by NOTCH1 R-HSA-1980143 2.945757e-02 1.531 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.987343e-02 1.525 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.987343e-02 1.525 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.009903e-02 1.521 0 0
Reproduction R-HSA-1474165 3.094152e-02 1.509 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 3.126543e-02 1.505 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.134916e-02 1.504 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.134916e-02 1.504 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.144305e-02 1.502 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.144305e-02 1.502 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.144305e-02 1.502 0 0
Interferon Signaling R-HSA-913531 3.168784e-02 1.499 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.178271e-02 1.498 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.178271e-02 1.498 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.204243e-02 1.494 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.213351e-02 1.493 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.214240e-02 1.493 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.214240e-02 1.493 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.285529e-02 1.483 0 0
Telomere Maintenance R-HSA-157579 3.297577e-02 1.482 0 0
Gene expression (Transcription) R-HSA-74160 3.305558e-02 1.481 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.331242e-02 1.477 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.331242e-02 1.477 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.434366e-02 1.464 0 0
G1/S Transition R-HSA-69206 3.497249e-02 1.456 0 0
G alpha (12/13) signalling events R-HSA-416482 3.498062e-02 1.456 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.520700e-02 1.453 0 0
Ion homeostasis R-HSA-5578775 3.524884e-02 1.453 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.562582e-02 1.448 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.562582e-02 1.448 0 0
MTOR signalling R-HSA-165159 3.603509e-02 1.443 0 0
Ca-dependent events R-HSA-111996 3.603509e-02 1.443 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.613073e-02 1.442 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.613073e-02 1.442 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.613073e-02 1.442 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.619765e-02 1.441 0 0
Nucleotide Excision Repair R-HSA-5696398 3.620208e-02 1.441 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.638761e-02 1.439 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.638761e-02 1.439 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.702693e-02 1.431 0 0
Neurodegenerative Diseases R-HSA-8863678 3.702693e-02 1.431 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.849159e-02 1.415 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.849540e-02 1.415 0 0
Regulation of signaling by CBL R-HSA-912631 3.903713e-02 1.409 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.903713e-02 1.409 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.924640e-02 1.406 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.924640e-02 1.406 0 0
Budding and maturation of HIV virion R-HSA-162588 3.924640e-02 1.406 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.944048e-02 1.404 0 0
HDL assembly R-HSA-8963896 3.944048e-02 1.404 0 0
Degradation of DVL R-HSA-4641258 4.017502e-02 1.396 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.017502e-02 1.396 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.024336e-02 1.395 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.010991e-02 1.300 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.010991e-02 1.300 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.612310e-02 1.336 0 0
Negative regulation of MET activity R-HSA-6807004 4.591157e-02 1.338 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 5.349278e-02 1.272 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.604976e-02 1.251 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.040196e-02 1.298 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.040196e-02 1.298 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.040196e-02 1.298 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.667581e-02 1.247 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.837195e-02 1.315 0 0
Metabolism of non-coding RNA R-HSA-194441 4.678757e-02 1.330 0 0
snRNP Assembly R-HSA-191859 4.678757e-02 1.330 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.776002e-02 1.238 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.820993e-02 1.317 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.040196e-02 1.298 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.485198e-02 1.261 0 0
Metalloprotease DUBs R-HSA-5689901 4.914768e-02 1.308 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.281044e-02 1.368 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.460850e-02 1.351 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.750370e-02 1.240 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.750370e-02 1.240 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.040772e-02 1.219 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.010991e-02 1.300 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.040196e-02 1.298 0 0
Glycogen synthesis R-HSA-3322077 4.591157e-02 1.338 0 0
HIV Life Cycle R-HSA-162587 4.162938e-02 1.381 0 0
Cilium Assembly R-HSA-5617833 4.427613e-02 1.354 0 0
PECAM1 interactions R-HSA-210990 5.741102e-02 1.241 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.040196e-02 1.298 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.115120e-02 1.291 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.776919e-02 1.321 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.811343e-02 1.236 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.510185e-02 1.346 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.964378e-02 1.304 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.352673e-02 1.271 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.041613e-02 1.297 0 0
PLC beta mediated events R-HSA-112043 5.578341e-02 1.253 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.612310e-02 1.336 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 5.041613e-02 1.297 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.767964e-02 1.322 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.667581e-02 1.247 0 0
Glucose metabolism R-HSA-70326 5.404216e-02 1.267 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.604976e-02 1.251 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.604976e-02 1.251 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.964378e-02 1.304 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.964378e-02 1.304 0 0
Pexophagy R-HSA-9664873 4.612310e-02 1.336 0 0
SARS-CoV Infections R-HSA-9679506 5.130438e-02 1.290 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.092937e-02 1.215 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.118561e-02 1.213 0 0
Assembly Of The HIV Virion R-HSA-175474 6.178931e-02 1.209 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 6.178931e-02 1.209 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.223878e-02 1.206 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.223878e-02 1.206 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.249902e-02 1.204 0 0
Dual Incision in GG-NER R-HSA-5696400 6.342407e-02 1.198 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.342407e-02 1.198 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.342407e-02 1.198 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.406042e-02 1.193 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.406042e-02 1.193 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.406042e-02 1.193 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.406042e-02 1.193 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.406042e-02 1.193 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.406042e-02 1.193 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.406042e-02 1.193 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.406042e-02 1.193 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.406042e-02 1.193 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.406042e-02 1.193 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.406042e-02 1.193 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.587289e-02 1.181 0 0
Signaling by PTK6 R-HSA-8848021 6.587289e-02 1.181 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.631992e-02 1.178 0 0
Nef and signal transduction R-HSA-164944 6.631992e-02 1.178 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 6.698793e-02 1.174 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.698793e-02 1.174 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.761363e-02 1.170 0 0
TNF signaling R-HSA-75893 6.926247e-02 1.160 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.926247e-02 1.160 0 0
Signaling by AXIN mutants R-HSA-4839735 7.003850e-02 1.155 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.003850e-02 1.155 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.003850e-02 1.155 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.065165e-02 1.151 0 0
Notch-HLH transcription pathway R-HSA-350054 7.080421e-02 1.150 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.080421e-02 1.150 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.157589e-02 1.145 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.157589e-02 1.145 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.526739e-02 1.123 0 0
RNA Polymerase II Transcription R-HSA-73857 7.697323e-02 1.114 0 0
Cellular response to hypoxia R-HSA-1234174 7.708757e-02 1.113 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.804899e-02 1.108 0 0
Glycogen storage diseases R-HSA-3229121 7.804899e-02 1.108 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.824010e-02 1.107 0 0
RET signaling R-HSA-8853659 7.836116e-02 1.106 0 0
Signaling by Interleukins R-HSA-449147 7.905060e-02 1.102 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.020510e-02 1.096 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 8.053506e-02 1.094 0 0
Signaling by FGFR4 R-HSA-5654743 8.303548e-02 1.081 0 0
TBC/RABGAPs R-HSA-8854214 8.303548e-02 1.081 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.396408e-02 1.076 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.396408e-02 1.076 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.396408e-02 1.076 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.396408e-02 1.076 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.396408e-02 1.076 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.396408e-02 1.076 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 8.460067e-02 1.073 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.460067e-02 1.073 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.619246e-02 1.065 0 0
Rab regulation of trafficking R-HSA-9007101 8.639568e-02 1.064 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.655288e-02 1.063 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.655288e-02 1.063 0 0
Regulation of beta-cell development R-HSA-186712 8.823586e-02 1.054 0 0
EGFR downregulation R-HSA-182971 8.940950e-02 1.049 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.944734e-02 1.048 0 0
G-protein mediated events R-HSA-112040 8.944734e-02 1.048 0 0
Downstream TCR signaling R-HSA-202424 8.984837e-02 1.046 0 0
Ephrin signaling R-HSA-3928664 9.002717e-02 1.046 0 0
PKA activation R-HSA-163615 9.002717e-02 1.046 0 0
PKA activation in glucagon signalling R-HSA-164378 9.002717e-02 1.046 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 9.375127e-02 1.028 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 9.375127e-02 1.028 0 0
MET interacts with TNS proteins R-HSA-8875513 9.375127e-02 1.028 0 0
MET activates PTPN11 R-HSA-8865999 9.375127e-02 1.028 0 0
HCMV Late Events R-HSA-9610379 9.601782e-02 1.018 0 0
Drug resistance of KIT mutants R-HSA-9669937 9.728136e-02 1.012 0 0
KIT mutants bind TKIs R-HSA-9669921 9.728136e-02 1.012 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 9.728136e-02 1.012 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 9.728136e-02 1.012 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.728136e-02 1.012 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 9.728136e-02 1.012 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 9.728136e-02 1.012 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 9.728136e-02 1.012 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 9.728136e-02 1.012 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 9.728136e-02 1.012 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 9.728136e-02 1.012 0 0
Signaling by FGFR3 R-HSA-5654741 9.896364e-02 1.005 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.896364e-02 1.005 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.896364e-02 1.005 0 0
Diseases of mitotic cell cycle R-HSA-9675126 9.918325e-02 1.004 0 0
Formation of annular gap junctions R-HSA-196025 1.047627e-01 0.980 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.075424e-01 0.968 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.087992e-01 0.963 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.095173e-01 0.961 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.095173e-01 0.961 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.095173e-01 0.961 0 0
ABC-family proteins mediated transport R-HSA-382556 1.123012e-01 0.950 0 0
Adaptive Immune System R-HSA-1280218 1.127481e-01 0.948 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.139219e-01 0.943 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.139219e-01 0.943 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.139897e-01 0.943 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.154664e-01 0.938 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.154664e-01 0.938 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.166228e-01 0.933 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.166228e-01 0.933 0 0
Protein hydroxylation R-HSA-9629569 1.166228e-01 0.933 0 0
Nephrin family interactions R-HSA-373753 1.166228e-01 0.933 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.176201e-01 0.930 0 0
Interleukin-1 signaling R-HSA-9020702 1.185673e-01 0.926 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.240669e-01 0.906 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.240675e-01 0.906 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.240675e-01 0.906 0 0
FLT3 Signaling R-HSA-9607240 1.240675e-01 0.906 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.263913e-01 0.898 0 0
Signaling by EGFR R-HSA-177929 1.265064e-01 0.898 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.265064e-01 0.898 0 0
Regulation of gap junction activity R-HSA-191650 1.265243e-01 0.898 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.265243e-01 0.898 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.265243e-01 0.898 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.265243e-01 0.898 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.265243e-01 0.898 0 0
Lipophagy R-HSA-9613354 1.265981e-01 0.898 0 0
Gap junction degradation R-HSA-190873 1.265981e-01 0.898 0 0
ALK mutants bind TKIs R-HSA-9700645 1.265981e-01 0.898 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.265981e-01 0.898 0 0
Unwinding of DNA R-HSA-176974 1.265981e-01 0.898 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.265981e-01 0.898 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.265981e-01 0.898 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.851042e-01 0.733 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.851042e-01 0.733 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.851042e-01 0.733 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.851042e-01 0.733 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.851042e-01 0.733 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.851042e-01 0.733 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.614996e-01 0.792 0 0
Co-inhibition by BTLA R-HSA-9927353 1.614996e-01 0.792 0 0
IRS activation R-HSA-74713 1.614996e-01 0.792 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.614996e-01 0.792 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 1.614996e-01 0.792 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.979393e-01 0.703 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.979393e-01 0.703 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.498896e-01 0.824 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.352279e-01 0.629 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.352279e-01 0.629 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.744172e-01 0.758 0 0
Signaling by APC mutants R-HSA-4839744 1.744172e-01 0.758 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.744172e-01 0.758 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.744172e-01 0.758 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.744172e-01 0.758 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.328909e-01 0.877 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.328909e-01 0.877 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.328909e-01 0.877 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.328909e-01 0.877 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.513137e-01 0.820 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.706387e-01 0.768 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.263186e-01 0.645 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.263186e-01 0.645 0 0
Pervasive developmental disorders R-HSA-9005895 2.263186e-01 0.645 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.263186e-01 0.645 0 0
Disorders of Nervous System Development R-HSA-9697154 2.263186e-01 0.645 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.263186e-01 0.645 0 0
Polymerase switching R-HSA-69091 2.263186e-01 0.645 0 0
Leading Strand Synthesis R-HSA-69109 2.263186e-01 0.645 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.907658e-01 0.719 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.907658e-01 0.719 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.532816e-01 0.596 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.532816e-01 0.596 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.115923e-01 0.675 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.115923e-01 0.675 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.330149e-01 0.633 0 0
Long-term potentiation R-HSA-9620244 2.143794e-01 0.669 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.455606e-01 0.837 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.549312e-01 0.594 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.549312e-01 0.594 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.549312e-01 0.594 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.549312e-01 0.594 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.549312e-01 0.594 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.549312e-01 0.594 0 0
Cristae formation R-HSA-8949613 2.514827e-01 0.599 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.672262e-01 0.777 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.784490e-01 0.748 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.460347e-01 0.609 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.140345e-01 0.670 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.143794e-01 0.669 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.143794e-01 0.669 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.824208e-01 0.739 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.327198e-01 0.633 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.327198e-01 0.633 0 0
Integrin signaling R-HSA-354192 2.133214e-01 0.671 0 0
Polo-like kinase mediated events R-HSA-156711 2.115923e-01 0.675 0 0
DNA strand elongation R-HSA-69190 1.975659e-01 0.704 0 0
Developmental Cell Lineages R-HSA-9734767 1.497992e-01 0.824 0 0
Frs2-mediated activation R-HSA-170968 2.532816e-01 0.596 0 0
DCC mediated attractive signaling R-HSA-418885 1.328909e-01 0.877 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.243847e-01 0.649 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.614996e-01 0.792 0 0
Regulation of CDH11 function R-HSA-9762292 1.498896e-01 0.824 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.706387e-01 0.768 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.394914e-01 0.855 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.514827e-01 0.599 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.706387e-01 0.768 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.327198e-01 0.633 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.734596e-01 0.761 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.999636e-01 0.699 0 0
Myogenesis R-HSA-525793 2.327198e-01 0.633 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.644603e-01 0.784 0 0
Signaling by WNT in cancer R-HSA-4791275 1.975659e-01 0.704 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.979393e-01 0.703 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.706387e-01 0.768 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.455606e-01 0.837 0 0
Intraflagellar transport R-HSA-5620924 2.196134e-01 0.658 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.249536e-01 0.648 0 0
Regulation of pyruvate metabolism R-HSA-9861718 1.934804e-01 0.713 0 0
mTORC1-mediated signalling R-HSA-166208 1.625160e-01 0.789 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.569486e-01 0.804 0 0
Signaling by FGFR2 R-HSA-5654738 1.970449e-01 0.705 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.455606e-01 0.837 0 0
Interleukin-7 signaling R-HSA-1266695 2.143794e-01 0.669 0 0
Circadian clock R-HSA-9909396 1.320758e-01 0.879 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.352279e-01 0.629 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.311664e-01 0.882 0 0
Protein methylation R-HSA-8876725 1.328909e-01 0.877 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.464811e-01 0.834 0 0
Regulated Necrosis R-HSA-5218859 2.558842e-01 0.592 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.445956e-01 0.612 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.756954e-01 0.755 0 0
Mitophagy R-HSA-5205647 2.460347e-01 0.609 0 0
Cellular response to chemical stress R-HSA-9711123 1.325573e-01 0.878 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.230120e-01 0.652 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.851042e-01 0.733 0 0
Inhibition of PKR R-HSA-169131 1.851042e-01 0.733 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 1.614996e-01 0.792 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.979393e-01 0.703 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.352279e-01 0.629 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.513137e-01 0.820 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.513137e-01 0.820 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.513137e-01 0.820 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.999636e-01 0.699 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.999636e-01 0.699 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.907658e-01 0.719 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 2.532816e-01 0.596 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.531929e-01 0.815 0 0
DARPP-32 events R-HSA-180024 1.531929e-01 0.815 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.318152e-01 0.880 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.809270e-01 0.742 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.635999e-01 0.786 0 0
Signaling by FGFR1 R-HSA-5654736 2.140345e-01 0.670 0 0
Generic Transcription Pathway R-HSA-212436 1.906816e-01 0.720 0 0
Inflammasomes R-HSA-622312 1.394914e-01 0.855 0 0
Glycogen metabolism R-HSA-8982491 2.103561e-01 0.677 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 1.649578e-01 0.783 1 1
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.416494e-01 0.849 0 0
Oncogene Induced Senescence R-HSA-2559585 1.437464e-01 0.842 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.921575e-01 0.716 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.575054e-01 0.589 0 0
The NLRP3 inflammasome R-HSA-844456 2.330149e-01 0.633 0 0
TGFBR3 expression R-HSA-9839394 2.143794e-01 0.669 0 0
MAP kinase activation R-HSA-450294 1.753693e-01 0.756 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.936227e-01 0.713 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.975659e-01 0.704 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.115923e-01 0.675 0 0
Generation of second messenger molecules R-HSA-202433 2.103561e-01 0.677 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.614996e-01 0.792 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.979393e-01 0.703 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.352279e-01 0.629 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.822666e-01 0.739 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.563478e-01 0.806 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.294917e-01 0.639 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.445956e-01 0.612 0 0
Ion channel transport R-HSA-983712 2.359846e-01 0.627 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.464811e-01 0.834 0 0
Plasma lipoprotein assembly R-HSA-8963898 1.965243e-01 0.707 0 0
PCP/CE pathway R-HSA-4086400 1.776082e-01 0.751 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.311664e-01 0.882 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.311664e-01 0.882 0 0
ABC transporter disorders R-HSA-5619084 1.776082e-01 0.751 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 1.979393e-01 0.703 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.355813e-01 0.628 0 0
FOXO-mediated transcription R-HSA-9614085 2.425141e-01 0.615 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.138490e-01 0.670 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.498896e-01 0.824 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.115923e-01 0.675 0 0
Nephron development R-HSA-9831926 2.115923e-01 0.675 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.327198e-01 0.633 0 0
Maturation of nucleoprotein R-HSA-9694631 2.330149e-01 0.633 0 0
Regulation of BACH1 activity R-HSA-9708530 1.513137e-01 0.820 0 0
Maturation of nucleoprotein R-HSA-9683610 2.532816e-01 0.596 0 0
Translation of Structural Proteins R-HSA-9694635 2.585819e-01 0.587 0 0
Translation of Structural Proteins R-HSA-9683701 2.397513e-01 0.620 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.629074e-01 0.580 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.643878e-01 0.578 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.643878e-01 0.578 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 2.643878e-01 0.578 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.643878e-01 0.578 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.643878e-01 0.578 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.643878e-01 0.578 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.643878e-01 0.578 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.643878e-01 0.578 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.643878e-01 0.578 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.643878e-01 0.578 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.643878e-01 0.578 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.643878e-01 0.578 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.643878e-01 0.578 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.643878e-01 0.578 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.643878e-01 0.578 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.643878e-01 0.578 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.643878e-01 0.578 0 0
Signaling by SCF-KIT R-HSA-1433557 2.703614e-01 0.568 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.706053e-01 0.568 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.728557e-01 0.564 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.728557e-01 0.564 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.728557e-01 0.564 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.728557e-01 0.564 0 0
SOS-mediated signalling R-HSA-112412 2.728557e-01 0.564 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 2.728557e-01 0.564 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.728557e-01 0.564 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.730118e-01 0.564 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.730118e-01 0.564 0 0
mRNA 3'-end processing R-HSA-72187 2.753495e-01 0.560 0 0
Neurexins and neuroligins R-HSA-6794361 2.753495e-01 0.560 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.787014e-01 0.555 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.787014e-01 0.555 0 0
Signal regulatory protein family interactions R-HSA-391160 2.806643e-01 0.552 0 0
Interleukin-17 signaling R-HSA-448424 2.809142e-01 0.551 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.830838e-01 0.548 0 0
Cyclin D associated events in G1 R-HSA-69231 2.860424e-01 0.544 0 0
G1 Phase R-HSA-69236 2.860424e-01 0.544 0 0
Netrin-1 signaling R-HSA-373752 2.860424e-01 0.544 0 0
RMTs methylate histone arginines R-HSA-3214858 2.860424e-01 0.544 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.900249e-01 0.538 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.900249e-01 0.538 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.900249e-01 0.538 0 0
tRNA processing in the nucleus R-HSA-6784531 2.922687e-01 0.534 0 0
Opioid Signalling R-HSA-111885 2.938978e-01 0.532 0 0
Interleukin-1 family signaling R-HSA-446652 2.960499e-01 0.529 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.998451e-01 0.523 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.998451e-01 0.523 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.998451e-01 0.523 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.998451e-01 0.523 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.019311e-01 0.520 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.019311e-01 0.520 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.060005e-01 0.514 0 0
ER-Phagosome pathway R-HSA-1236974 3.062378e-01 0.514 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.082916e-01 0.511 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.096798e-01 0.509 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.096798e-01 0.509 0 0
Activation of the pre-replicative complex R-HSA-68962 3.096798e-01 0.509 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.096798e-01 0.509 0 0
MET receptor recycling R-HSA-8875656 3.104042e-01 0.508 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.104042e-01 0.508 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.104042e-01 0.508 0 0
Ion transport by P-type ATPases R-HSA-936837 3.198765e-01 0.495 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.226511e-01 0.491 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.226511e-01 0.491 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.280802e-01 0.484 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.280802e-01 0.484 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.280802e-01 0.484 0 0
Trafficking of AMPA receptors R-HSA-399719 3.295097e-01 0.482 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.328264e-01 0.478 0 0
Signaling by ERBB4 R-HSA-1236394 3.328447e-01 0.478 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.342020e-01 0.476 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.342020e-01 0.476 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.359618e-01 0.474 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.359618e-01 0.474 0 0
Potassium transport channels R-HSA-1296067 3.359618e-01 0.474 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.359618e-01 0.474 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.359618e-01 0.474 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.359618e-01 0.474 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.359618e-01 0.474 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.359618e-01 0.474 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.359618e-01 0.474 0 0
C6 deamination of adenosine R-HSA-75102 3.359618e-01 0.474 0 0
Signalling to ERK5 R-HSA-198765 3.359618e-01 0.474 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.360029e-01 0.474 0 0
Phosphorylation of the APC/C R-HSA-176412 3.360029e-01 0.474 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.360029e-01 0.474 0 0
Prolonged ERK activation events R-HSA-169893 3.360029e-01 0.474 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.360029e-01 0.474 0 0
Activation of SMO R-HSA-5635838 3.360029e-01 0.474 0 0
Cardiac conduction R-HSA-5576891 3.396994e-01 0.469 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.455689e-01 0.461 0 0
Growth hormone receptor signaling R-HSA-982772 3.455689e-01 0.461 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.461184e-01 0.461 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.475328e-01 0.459 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.475328e-01 0.459 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.475328e-01 0.459 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.475328e-01 0.459 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.475328e-01 0.459 0 0
ARMS-mediated activation R-HSA-170984 3.475328e-01 0.459 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.475328e-01 0.459 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.475328e-01 0.459 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.475328e-01 0.459 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.475328e-01 0.459 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.481473e-01 0.458 0 0
Stimuli-sensing channels R-HSA-2672351 3.481473e-01 0.458 0 0
G0 and Early G1 R-HSA-1538133 3.494561e-01 0.457 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.494561e-01 0.457 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.505202e-01 0.455 0 0
Co-stimulation by CD28 R-HSA-389356 3.505202e-01 0.455 0 0
NGF-stimulated transcription R-HSA-9031628 3.505202e-01 0.455 0 0
Protein folding R-HSA-391251 3.538545e-01 0.451 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.592379e-01 0.445 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.631042e-01 0.440 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.631042e-01 0.440 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.631042e-01 0.440 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.636522e-01 0.439 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 3.636522e-01 0.439 0 0
Disorders of Developmental Biology R-HSA-9675151 3.636522e-01 0.439 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.636522e-01 0.439 0 0
Dual incision in TC-NER R-HSA-6782135 3.646869e-01 0.438 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.685141e-01 0.434 0 0
Deadenylation of mRNA R-HSA-429947 3.685141e-01 0.434 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.685141e-01 0.434 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.685141e-01 0.434 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.686452e-01 0.433 0 0
G-protein beta:gamma signalling R-HSA-397795 3.694624e-01 0.432 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.694624e-01 0.432 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.694624e-01 0.432 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.694624e-01 0.432 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.774647e-01 0.423 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.839680e-01 0.416 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.839680e-01 0.416 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.839680e-01 0.416 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.839680e-01 0.416 0 0
PI3K/AKT activation R-HSA-198203 3.839680e-01 0.416 0 0
Signal attenuation R-HSA-74749 3.839680e-01 0.416 0 0
2-LTR circle formation R-HSA-164843 3.839680e-01 0.416 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.839680e-01 0.416 0 0
Signaling by Leptin R-HSA-2586552 3.839680e-01 0.416 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.894746e-01 0.410 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.903206e-01 0.409 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.911083e-01 0.408 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.911083e-01 0.408 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.911083e-01 0.408 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.914074e-01 0.407 0 0
Infectious disease R-HSA-5663205 3.925009e-01 0.406 0 0
Inositol phosphate metabolism R-HSA-1483249 3.928182e-01 0.406 0 0
Pyruvate metabolism R-HSA-70268 3.949805e-01 0.403 0 0
Integration of energy metabolism R-HSA-163685 4.000043e-01 0.398 0 0
The NLRP1 inflammasome R-HSA-844455 4.005756e-01 0.397 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.005756e-01 0.397 0 0
The IPAF inflammasome R-HSA-844623 4.005756e-01 0.397 0 0
Invadopodia formation R-HSA-8941237 4.005756e-01 0.397 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.005756e-01 0.397 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.005756e-01 0.397 0 0
Defective CYP1B1 causes Glaucoma R-HSA-5579000 4.005756e-01 0.397 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.005756e-01 0.397 0 0
MET activates STAT3 R-HSA-8875791 4.005756e-01 0.397 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.005756e-01 0.397 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.005756e-01 0.397 0 0
Histamine receptors R-HSA-390650 4.005756e-01 0.397 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.040824e-01 0.394 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.094415e-01 0.388 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.094415e-01 0.388 0 0
Formation of paraxial mesoderm R-HSA-9793380 4.104746e-01 0.387 0 0
Signaling by MET R-HSA-6806834 4.133873e-01 0.384 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.141752e-01 0.383 0 0
TRP channels R-HSA-3295583 4.141752e-01 0.383 0 0
GAB1 signalosome R-HSA-180292 4.182545e-01 0.379 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.182545e-01 0.379 0 0
Mismatch Repair R-HSA-5358508 4.182545e-01 0.379 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.182545e-01 0.379 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.194934e-01 0.377 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.194934e-01 0.377 0 0
Interleukin-2 signaling R-HSA-9020558 4.194934e-01 0.377 0 0
Formation of the posterior neural plate R-HSA-9832991 4.194934e-01 0.377 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 4.194934e-01 0.377 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.194934e-01 0.377 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.194934e-01 0.377 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.225372e-01 0.374 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.293142e-01 0.367 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.367496e-01 0.360 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.367496e-01 0.360 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.367496e-01 0.360 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.367496e-01 0.360 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.367496e-01 0.360 0 0
Signaling by FGFR R-HSA-190236 4.393151e-01 0.357 0 0
Regulation of insulin secretion R-HSA-422356 4.393151e-01 0.357 0 0
Proteasome assembly R-HSA-9907900 4.403966e-01 0.356 0 0
Specification of the neural plate border R-HSA-9834899 4.449883e-01 0.352 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.449883e-01 0.352 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.449883e-01 0.352 0 0
Ca2+ pathway R-HSA-4086398 4.479138e-01 0.349 0 0
RUNX2 regulates bone development R-HSA-8941326 4.490474e-01 0.348 0 0
G1/S-Specific Transcription R-HSA-69205 4.490474e-01 0.348 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.538801e-01 0.343 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.539412e-01 0.343 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.539412e-01 0.343 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.539412e-01 0.343 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.539412e-01 0.343 0 0
Integration of provirus R-HSA-162592 4.539412e-01 0.343 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.539412e-01 0.343 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.539412e-01 0.343 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.539412e-01 0.343 0 0
Antigen processing-Cross presentation R-HSA-1236975 4.562501e-01 0.341 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.575005e-01 0.340 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.581196e-01 0.339 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.581466e-01 0.339 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.581466e-01 0.339 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.581466e-01 0.339 0 0
Somitogenesis R-HSA-9824272 4.581466e-01 0.339 0 0
HCN channels R-HSA-1296061 4.589056e-01 0.338 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.589056e-01 0.338 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.589056e-01 0.338 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.589056e-01 0.338 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.589056e-01 0.338 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.589056e-01 0.338 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.589056e-01 0.338 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.589056e-01 0.338 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.589056e-01 0.338 0 0
Sensory perception of sour taste R-HSA-9729555 4.589056e-01 0.338 0 0
NADE modulates death signalling R-HSA-205025 4.589056e-01 0.338 0 0
Dopamine receptors R-HSA-390651 4.589056e-01 0.338 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.590686e-01 0.338 0 0
HIV elongation arrest and recovery R-HSA-167287 4.590686e-01 0.338 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.590686e-01 0.338 0 0
Insulin receptor recycling R-HSA-77387 4.590686e-01 0.338 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.712203e-01 0.327 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.712203e-01 0.327 0 0
Signal transduction by L1 R-HSA-445144 4.712203e-01 0.327 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 4.718593e-01 0.326 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 4.718593e-01 0.326 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.757560e-01 0.323 0 0
Diseases of DNA repair R-HSA-9675135 4.757560e-01 0.323 0 0
Signaling by TGFBR3 R-HSA-9839373 4.757560e-01 0.323 0 0
Immune System R-HSA-168256 4.800305e-01 0.319 0 0
Platelet calcium homeostasis R-HSA-418360 4.810761e-01 0.318 0 0
Platelet degranulation R-HSA-114608 4.860579e-01 0.313 0 0
Repression of WNT target genes R-HSA-4641265 4.871848e-01 0.312 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.871848e-01 0.312 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.871848e-01 0.312 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.871848e-01 0.312 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.871848e-01 0.312 0 0
Signaling by LTK R-HSA-9842663 4.871848e-01 0.312 0 0
MET promotes cell motility R-HSA-8875878 4.879282e-01 0.312 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.879282e-01 0.312 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.931951e-01 0.307 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.939649e-01 0.306 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.940146e-01 0.306 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.941315e-01 0.306 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.941315e-01 0.306 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.968256e-01 0.304 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.968742e-01 0.304 0 0
Lagging Strand Synthesis R-HSA-69186 4.968742e-01 0.304 0 0
Basigin interactions R-HSA-210991 4.968742e-01 0.304 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.027216e-01 0.299 0 0
Interleukin-37 signaling R-HSA-9008059 5.027216e-01 0.299 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.066460e-01 0.295 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.070002e-01 0.295 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.070002e-01 0.295 0 0
Signaling by ALK R-HSA-201556 5.070002e-01 0.295 0 0
RAS processing R-HSA-9648002 5.070002e-01 0.295 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.071702e-01 0.295 0 0
GPER1 signaling R-HSA-9634597 5.104365e-01 0.292 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.115626e-01 0.291 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.115626e-01 0.291 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.115626e-01 0.291 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.115626e-01 0.291 0 0
Defective F9 activation R-HSA-9673221 5.115626e-01 0.291 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.115626e-01 0.291 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.115626e-01 0.291 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.115626e-01 0.291 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.115626e-01 0.291 0 0
Inositol transporters R-HSA-429593 5.115626e-01 0.291 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.115626e-01 0.291 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.178512e-01 0.286 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.191324e-01 0.285 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.191324e-01 0.285 0 0
Formation of axial mesoderm R-HSA-9796292 5.191324e-01 0.285 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.191324e-01 0.285 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.191324e-01 0.285 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.191324e-01 0.285 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.191324e-01 0.285 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.217207e-01 0.283 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.218854e-01 0.282 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.239603e-01 0.281 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.257816e-01 0.279 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.257816e-01 0.279 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.257816e-01 0.279 0 0
Diseases of Immune System R-HSA-5260271 5.257816e-01 0.279 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.272945e-01 0.278 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.272945e-01 0.278 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 5.274547e-01 0.278 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.316610e-01 0.274 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.330001e-01 0.273 0 0
Hemostasis R-HSA-109582 5.331344e-01 0.273 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.442424e-01 0.264 0 0
FGFR2 alternative splicing R-HSA-6803529 5.462005e-01 0.263 0 0
Removal of the Flap Intermediate R-HSA-69166 5.497214e-01 0.260 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.497214e-01 0.260 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.497214e-01 0.260 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.497214e-01 0.260 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.497214e-01 0.260 0 0
Physiological factors R-HSA-5578768 5.497214e-01 0.260 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.590981e-01 0.253 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.590981e-01 0.253 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.590981e-01 0.253 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.590981e-01 0.253 0 0
PKB-mediated events R-HSA-109703 5.590981e-01 0.253 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.590981e-01 0.253 0 0
PDE3B signalling R-HSA-165160 5.590981e-01 0.253 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.590981e-01 0.253 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 5.590981e-01 0.253 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.590981e-01 0.253 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.590981e-01 0.253 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.590981e-01 0.253 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.590981e-01 0.253 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.590981e-01 0.253 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.590981e-01 0.253 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.590981e-01 0.253 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.590981e-01 0.253 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.590981e-01 0.253 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.590981e-01 0.253 0 0
Interferon alpha/beta signaling R-HSA-909733 5.594451e-01 0.252 0 0
Nuclear RNA decay R-HSA-9930044 5.650649e-01 0.248 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.650649e-01 0.248 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.650649e-01 0.248 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.697761e-01 0.244 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.697761e-01 0.244 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.732656e-01 0.242 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.769448e-01 0.239 0 0
Erythropoietin activates RAS R-HSA-9027284 5.789138e-01 0.237 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.789138e-01 0.237 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.789138e-01 0.237 0 0
Formation of the anterior neural plate R-HSA-9823739 5.789138e-01 0.237 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.789138e-01 0.237 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.848674e-01 0.233 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.848674e-01 0.233 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.928548e-01 0.227 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.020099e-01 0.220 0 0
Signaling by LTK in cancer R-HSA-9842640 6.020099e-01 0.220 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.020099e-01 0.220 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.020099e-01 0.220 0 0
MET Receptor Activation R-HSA-6806942 6.020099e-01 0.220 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.020099e-01 0.220 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.020099e-01 0.220 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.020099e-01 0.220 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.020099e-01 0.220 0 0
NADPH regeneration R-HSA-389542 6.020099e-01 0.220 0 0
Neurofascin interactions R-HSA-447043 6.020099e-01 0.220 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.041360e-01 0.219 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.066915e-01 0.217 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.066915e-01 0.217 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.066915e-01 0.217 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.066915e-01 0.217 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.106846e-01 0.214 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.145817e-01 0.211 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.145817e-01 0.211 0 0
HDMs demethylate histones R-HSA-3214842 6.145817e-01 0.211 0 0
Formation of the nephric duct R-HSA-9830364 6.145817e-01 0.211 0 0
Signaling by NTRKs R-HSA-166520 6.284518e-01 0.202 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.330535e-01 0.199 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.330535e-01 0.199 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.357686e-01 0.197 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 6.386055e-01 0.195 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.407475e-01 0.193 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.407475e-01 0.193 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 6.407475e-01 0.193 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.407475e-01 0.193 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.407475e-01 0.193 0 0
Disinhibition of SNARE formation R-HSA-114516 6.407475e-01 0.193 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.407475e-01 0.193 0 0
Recycling of eIF2:GDP R-HSA-72731 6.407475e-01 0.193 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.407475e-01 0.193 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.407475e-01 0.193 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.407475e-01 0.193 0 0
VLDL clearance R-HSA-8964046 6.407475e-01 0.193 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.407475e-01 0.193 0 0
CHL1 interactions R-HSA-447041 6.407475e-01 0.193 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.407475e-01 0.193 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.407475e-01 0.193 0 0
Maturation of replicase proteins R-HSA-9694301 6.407475e-01 0.193 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.409955e-01 0.193 0 0
RNA Polymerase III Transcription R-HSA-74158 6.409955e-01 0.193 0 0
Triglyceride catabolism R-HSA-163560 6.409955e-01 0.193 0 0
Signaling by TGFB family members R-HSA-9006936 6.449351e-01 0.190 0 0
Kidney development R-HSA-9830369 6.459377e-01 0.190 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.490804e-01 0.188 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.561279e-01 0.183 0 0
Toll-like Receptor Cascades R-HSA-168898 6.566196e-01 0.183 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.580122e-01 0.182 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.580122e-01 0.182 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.580122e-01 0.182 0 0
Specification of primordial germ cells R-HSA-9827857 6.580122e-01 0.182 0 0
Transcription of the HIV genome R-HSA-167172 6.592993e-01 0.181 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.755314e-01 0.170 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.755314e-01 0.170 0 0
Pyroptosis R-HSA-5620971 6.756549e-01 0.170 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.757167e-01 0.170 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.757167e-01 0.170 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.757167e-01 0.170 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.757167e-01 0.170 0 0
Interleukin-9 signaling R-HSA-8985947 6.757167e-01 0.170 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.757167e-01 0.170 0 0
Regulation by c-FLIP R-HSA-3371378 6.757167e-01 0.170 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.757167e-01 0.170 0 0
Dimerization of procaspase-8 R-HSA-69416 6.757167e-01 0.170 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.757167e-01 0.170 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.757167e-01 0.170 0 0
Gluconeogenesis R-HSA-70263 6.777814e-01 0.169 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.811524e-01 0.167 0 0
Peroxisomal protein import R-HSA-9033241 6.811524e-01 0.167 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.815909e-01 0.166 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.815909e-01 0.166 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.815909e-01 0.166 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.815909e-01 0.166 0 0
Platelet sensitization by LDL R-HSA-432142 6.815909e-01 0.166 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.850843e-01 0.164 0 0
FCERI mediated NF-kB activation R-HSA-2871837 6.854160e-01 0.164 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.919090e-01 0.160 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.919090e-01 0.160 0 0
Signaling by Erythropoietin R-HSA-9006335 6.943500e-01 0.158 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.038218e-01 0.153 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.038218e-01 0.153 0 0
Other interleukin signaling R-HSA-449836 7.038218e-01 0.153 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.038218e-01 0.153 0 0
PI3K Cascade R-HSA-109704 7.067341e-01 0.151 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.072839e-01 0.150 0 0
CASP8 activity is inhibited R-HSA-5218900 7.072839e-01 0.150 0 0
Interleukin-21 signaling R-HSA-9020958 7.072839e-01 0.150 0 0
Calcineurin activates NFAT R-HSA-2025928 7.072839e-01 0.150 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.072839e-01 0.150 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.072839e-01 0.150 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.072839e-01 0.150 0 0
mRNA Editing R-HSA-75072 7.072839e-01 0.150 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.072839e-01 0.150 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.072839e-01 0.150 0 0
WNT mediated activation of DVL R-HSA-201688 7.072839e-01 0.150 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.072839e-01 0.150 0 0
Expression of NOTCH2NL genes R-HSA-9911233 7.072839e-01 0.150 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.072839e-01 0.150 0 0
Interleukin-1 processing R-HSA-448706 7.072839e-01 0.150 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.072839e-01 0.150 0 0
Aquaporin-mediated transport R-HSA-445717 7.076378e-01 0.150 0 0
HIV Transcription Elongation R-HSA-167169 7.076892e-01 0.150 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.076892e-01 0.150 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.076892e-01 0.150 0 0
Interleukin-2 family signaling R-HSA-451927 7.076892e-01 0.150 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.083303e-01 0.150 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.122186e-01 0.147 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.122186e-01 0.147 0 0
Signaling by Insulin receptor R-HSA-74752 7.151602e-01 0.146 0 0
PI Metabolism R-HSA-1483255 7.183748e-01 0.144 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.199735e-01 0.143 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.203044e-01 0.142 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.247438e-01 0.140 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.247438e-01 0.140 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.247438e-01 0.140 0 0
Creatine metabolism R-HSA-71288 7.247438e-01 0.140 0 0
Formation of definitive endoderm R-HSA-9823730 7.247438e-01 0.140 0 0
Potential therapeutics for SARS R-HSA-9679191 7.356530e-01 0.133 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.357799e-01 0.133 0 0
Formation of apoptosome R-HSA-111458 7.357799e-01 0.133 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.357799e-01 0.133 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.357799e-01 0.133 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.357799e-01 0.133 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.357799e-01 0.133 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.357799e-01 0.133 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.357799e-01 0.133 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.374624e-01 0.132 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.444010e-01 0.128 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.444010e-01 0.128 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.444010e-01 0.128 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.444010e-01 0.128 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.455169e-01 0.128 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.459221e-01 0.127 0 0
RSV-host interactions R-HSA-9833110 7.471442e-01 0.127 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.512005e-01 0.124 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.609753e-01 0.119 0 0
Cardiogenesis R-HSA-9733709 7.609753e-01 0.119 0 0
LGI-ADAM interactions R-HSA-5682910 7.615033e-01 0.118 0 0
vRNP Assembly R-HSA-192905 7.615033e-01 0.118 0 0
Bicarbonate transporters R-HSA-425381 7.615033e-01 0.118 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.615033e-01 0.118 0 0
Transport of RCbl within the body R-HSA-9758890 7.615033e-01 0.118 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.615033e-01 0.118 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.628413e-01 0.118 0 0
Serine metabolism R-HSA-977347 7.628413e-01 0.118 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 7.628413e-01 0.118 0 0
G alpha (z) signalling events R-HSA-418597 7.709446e-01 0.113 0 0
Paracetamol ADME R-HSA-9753281 7.709446e-01 0.113 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.756634e-01 0.110 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.756634e-01 0.110 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.756634e-01 0.110 0 0
Signaling by KIT in disease R-HSA-9669938 7.801153e-01 0.108 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.801153e-01 0.108 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.801153e-01 0.108 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.801153e-01 0.108 0 0
LDL clearance R-HSA-8964038 7.801153e-01 0.108 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.801153e-01 0.108 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.801153e-01 0.108 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.847237e-01 0.105 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.847237e-01 0.105 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.847237e-01 0.105 0 0
ERKs are inactivated R-HSA-202670 7.847237e-01 0.105 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.847237e-01 0.105 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.847237e-01 0.105 0 0
Sodium/Calcium exchangers R-HSA-425561 7.847237e-01 0.105 0 0
eNOS activation R-HSA-203615 7.896018e-01 0.103 0 0
IRS-mediated signalling R-HSA-112399 7.934155e-01 0.100 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.962753e-01 0.099 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.962753e-01 0.099 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.962753e-01 0.099 0 0
Carnitine shuttle R-HSA-200425 7.962753e-01 0.099 0 0
Syndecan interactions R-HSA-3000170 7.962753e-01 0.099 0 0
Neddylation R-HSA-8951664 7.984360e-01 0.098 0 0
Interferon gamma signaling R-HSA-877300 8.007682e-01 0.096 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.017522e-01 0.096 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.017522e-01 0.096 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.017522e-01 0.096 0 0
Signalling to ERKs R-HSA-187687 8.028123e-01 0.095 0 0
MET activates RAS signaling R-HSA-8851805 8.056846e-01 0.094 0 0
Interleukin-15 signaling R-HSA-8983432 8.056846e-01 0.094 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.056846e-01 0.094 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.056846e-01 0.094 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.056846e-01 0.094 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.056846e-01 0.094 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.056846e-01 0.094 0 0
Regulation of IFNG signaling R-HSA-877312 8.056846e-01 0.094 0 0
OAS antiviral response R-HSA-8983711 8.056846e-01 0.094 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.056846e-01 0.094 0 0
Gastrulation R-HSA-9758941 8.064269e-01 0.093 0 0
Complex III assembly R-HSA-9865881 8.113744e-01 0.091 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.113744e-01 0.091 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.141221e-01 0.089 0 0
GPVI-mediated activation cascade R-HSA-114604 8.153185e-01 0.089 0 0
Glycosphingolipid transport R-HSA-9845576 8.153185e-01 0.089 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.205809e-01 0.086 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.232060e-01 0.084 0 0
Metabolism of polyamines R-HSA-351202 8.238346e-01 0.084 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.246058e-01 0.084 0 0
Processing of SMDT1 R-HSA-8949664 8.246058e-01 0.084 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.246058e-01 0.084 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.246058e-01 0.084 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.246058e-01 0.084 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.246058e-01 0.084 0 0
Interleukin-6 signaling R-HSA-1059683 8.246058e-01 0.084 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.254659e-01 0.083 0 0
Tight junction interactions R-HSA-420029 8.254659e-01 0.083 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.254659e-01 0.083 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.260012e-01 0.083 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.268204e-01 0.083 0 0
NCAM1 interactions R-HSA-419037 8.271447e-01 0.082 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.331220e-01 0.079 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.331325e-01 0.079 0 0
Collagen degradation R-HSA-1442490 8.331325e-01 0.079 0 0
MET activates PTK2 signaling R-HSA-8874081 8.386028e-01 0.076 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.386028e-01 0.076 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.386028e-01 0.076 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.386028e-01 0.076 0 0
Urea cycle R-HSA-70635 8.386028e-01 0.076 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.416855e-01 0.075 0 0
cGMP effects R-HSA-418457 8.416855e-01 0.075 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 8.416855e-01 0.075 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.416855e-01 0.075 0 0
Biosynthesis of protectins R-HSA-9018681 8.416855e-01 0.075 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.416855e-01 0.075 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.416855e-01 0.075 0 0
Malate-aspartate shuttle R-HSA-9856872 8.416855e-01 0.075 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.416855e-01 0.075 0 0
Zinc transporters R-HSA-435354 8.416855e-01 0.075 0 0
Heme signaling R-HSA-9707616 8.420257e-01 0.075 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.420257e-01 0.075 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.488579e-01 0.071 0 0
Iron uptake and transport R-HSA-917937 8.506549e-01 0.070 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.508374e-01 0.070 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.508374e-01 0.070 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.508374e-01 0.070 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.508374e-01 0.070 0 0
Insulin processing R-HSA-264876 8.508374e-01 0.070 0 0
Platelet homeostasis R-HSA-418346 8.508621e-01 0.070 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.521346e-01 0.069 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.571029e-01 0.067 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.571029e-01 0.067 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.571029e-01 0.067 0 0
Other semaphorin interactions R-HSA-416700 8.571029e-01 0.067 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.571029e-01 0.067 0 0
DNA Damage Reversal R-HSA-73942 8.571029e-01 0.067 0 0
IGF1R signaling cascade R-HSA-2428924 8.586407e-01 0.066 0 0
Insulin receptor signalling cascade R-HSA-74751 8.586407e-01 0.066 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.587962e-01 0.066 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.587962e-01 0.066 0 0
Neuronal System R-HSA-112316 8.617236e-01 0.065 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.622208e-01 0.064 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.622208e-01 0.064 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.622208e-01 0.064 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.626072e-01 0.064 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.654476e-01 0.063 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.663845e-01 0.062 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.681568e-01 0.061 0 0
Maturation of spike protein R-HSA-9694548 8.681568e-01 0.061 0 0
Nucleotide biosynthesis R-HSA-8956320 8.696687e-01 0.061 0 0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 8.710197e-01 0.060 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.710197e-01 0.060 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.710197e-01 0.060 0 0
Attachment and Entry R-HSA-9678110 8.710197e-01 0.060 0 0
Atorvastatin ADME R-HSA-9754706 8.710197e-01 0.060 0 0
Disease R-HSA-1643685 8.720799e-01 0.059 0 0
mRNA Capping R-HSA-72086 8.728026e-01 0.059 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.728026e-01 0.059 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.728026e-01 0.059 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.728026e-01 0.059 0 0
Glucagon-type ligand receptors R-HSA-420092 8.728026e-01 0.059 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.728026e-01 0.059 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.769653e-01 0.057 0 0
HIV Transcription Initiation R-HSA-167161 8.769653e-01 0.057 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.769653e-01 0.057 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.769653e-01 0.057 0 0
Leishmania phagocytosis R-HSA-9664417 8.775261e-01 0.057 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.775261e-01 0.057 0 0
Parasite infection R-HSA-9664407 8.775261e-01 0.057 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.826311e-01 0.054 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.826311e-01 0.054 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.826311e-01 0.054 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.826311e-01 0.054 0 0
Phase 2 - plateau phase R-HSA-5576893 8.835819e-01 0.054 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.835819e-01 0.054 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.835819e-01 0.054 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.835819e-01 0.054 0 0
Synthesis of PG R-HSA-1483148 8.835819e-01 0.054 0 0
Galactose catabolism R-HSA-70370 8.835819e-01 0.054 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.835819e-01 0.054 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.835819e-01 0.054 0 0
Innate Immune System R-HSA-168249 8.888803e-01 0.051 0 0
Protein localization R-HSA-9609507 8.896325e-01 0.051 0 0
IRE1alpha activates chaperones R-HSA-381070 8.904353e-01 0.050 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.917525e-01 0.050 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.930276e-01 0.049 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.949213e-01 0.048 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 8.949213e-01 0.048 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.949213e-01 0.048 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.949213e-01 0.048 0 0
Choline catabolism R-HSA-6798163 8.949213e-01 0.048 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.002113e-01 0.046 0 0
Amine ligand-binding receptors R-HSA-375280 9.003311e-01 0.046 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.049666e-01 0.043 0 0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 9.051567e-01 0.043 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 9.051567e-01 0.043 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.051567e-01 0.043 0 0
Apoptotic factor-mediated response R-HSA-111471 9.051567e-01 0.043 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.051567e-01 0.043 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.051567e-01 0.043 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.051567e-01 0.043 0 0
Transmission across Chemical Synapses R-HSA-112315 9.064488e-01 0.043 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.071817e-01 0.042 0 0
FGFR1 mutant receptor activation R-HSA-1839124 9.080500e-01 0.042 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.080500e-01 0.042 0 0
Extension of Telomeres R-HSA-180786 9.109147e-01 0.041 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.109147e-01 0.041 0 0
Triglyceride metabolism R-HSA-8979227 9.109147e-01 0.041 0 0
Leishmania infection R-HSA-9658195 9.123421e-01 0.040 0 0
Parasitic Infection Pathways R-HSA-9824443 9.123421e-01 0.040 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.136027e-01 0.039 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.143958e-01 0.039 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.143958e-01 0.039 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.143958e-01 0.039 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.143958e-01 0.039 0 0
Pyrimidine biosynthesis R-HSA-500753 9.143958e-01 0.039 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.143958e-01 0.039 0 0
Diseases of hemostasis R-HSA-9671793 9.143958e-01 0.039 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.143958e-01 0.039 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.153090e-01 0.038 0 0
Heme degradation R-HSA-189483 9.153090e-01 0.038 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.163257e-01 0.038 0 0
Mitochondrial biogenesis R-HSA-1592230 9.182951e-01 0.037 0 0
Synthesis of PC R-HSA-1483191 9.196170e-01 0.036 0 0
Signaling by FGFR in disease R-HSA-1226099 9.212408e-01 0.036 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.220270e-01 0.035 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.220270e-01 0.035 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.220270e-01 0.035 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.222605e-01 0.035 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.224100e-01 0.035 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.227353e-01 0.035 0 0
Signaling by NODAL R-HSA-1181150 9.227353e-01 0.035 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.227353e-01 0.035 0 0
Metal ion SLC transporters R-HSA-425410 9.252463e-01 0.034 0 0
Mitochondrial protein import R-HSA-1268020 9.268171e-01 0.033 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.282404e-01 0.032 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.282404e-01 0.032 0 0
PERK regulates gene expression R-HSA-381042 9.282404e-01 0.032 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.282404e-01 0.032 0 0
G-protein activation R-HSA-202040 9.302628e-01 0.031 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.302628e-01 0.031 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.302628e-01 0.031 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.302628e-01 0.031 0 0
Phenylalanine metabolism R-HSA-8964208 9.302628e-01 0.031 0 0
ERK/MAPK targets R-HSA-198753 9.302628e-01 0.031 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.302628e-01 0.031 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.302628e-01 0.031 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.315201e-01 0.031 0 0
Adipogenesis R-HSA-9843745 9.324437e-01 0.030 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.339837e-01 0.030 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.339837e-01 0.030 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.354342e-01 0.029 0 0
Azathioprine ADME R-HSA-9748787 9.354342e-01 0.029 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.370573e-01 0.028 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.370573e-01 0.028 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.370573e-01 0.028 0 0
Glutathione synthesis and recycling R-HSA-174403 9.370573e-01 0.028 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.370573e-01 0.028 0 0
Attachment and Entry R-HSA-9694614 9.370573e-01 0.028 0 0
Voltage gated Potassium channels R-HSA-1296072 9.392896e-01 0.027 0 0
Metabolism of folate and pterines R-HSA-196757 9.392896e-01 0.027 0 0
Collagen chain trimerization R-HSA-8948216 9.392896e-01 0.027 0 0
The phototransduction cascade R-HSA-2514856 9.400328e-01 0.027 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.431902e-01 0.025 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.431902e-01 0.025 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.431902e-01 0.025 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.431902e-01 0.025 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.431902e-01 0.025 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.441887e-01 0.025 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.443263e-01 0.025 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.443263e-01 0.025 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.477146e-01 0.023 0 0
Nicotinate metabolism R-HSA-196807 9.477146e-01 0.023 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.483328e-01 0.023 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.487098e-01 0.023 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.487259e-01 0.023 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.487259e-01 0.023 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.487259e-01 0.023 0 0
Formation of the ureteric bud R-HSA-9830674 9.487259e-01 0.023 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.487259e-01 0.023 0 0
Interleukin-20 family signaling R-HSA-8854691 9.487259e-01 0.023 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.528802e-01 0.021 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.537225e-01 0.021 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.537225e-01 0.021 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.537225e-01 0.021 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.537225e-01 0.021 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.537225e-01 0.021 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.537225e-01 0.021 0 0
Interleukin-6 family signaling R-HSA-6783589 9.537225e-01 0.021 0 0
Mitochondrial protein degradation R-HSA-9837999 9.541617e-01 0.020 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.574685e-01 0.019 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.582324e-01 0.019 0 0
G protein gated Potassium channels R-HSA-1296059 9.582324e-01 0.019 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.582324e-01 0.019 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.582324e-01 0.019 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.582324e-01 0.019 0 0
Hyaluronan degradation R-HSA-2160916 9.582324e-01 0.019 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.582324e-01 0.019 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.582324e-01 0.019 0 0
Intra-Golgi traffic R-HSA-6811438 9.602685e-01 0.018 0 0
Metabolism of cofactors R-HSA-8978934 9.603266e-01 0.018 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.623030e-01 0.017 0 0
Sphingolipid catabolism R-HSA-9845614 9.623030e-01 0.017 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.635326e-01 0.016 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.635326e-01 0.016 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.646308e-01 0.016 0 0
Synthesis of PE R-HSA-1483213 9.659772e-01 0.015 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.678672e-01 0.014 0 0
Telomere Extension By Telomerase R-HSA-171319 9.692934e-01 0.014 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.692934e-01 0.014 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.692934e-01 0.014 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.693043e-01 0.014 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.700680e-01 0.013 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.722866e-01 0.012 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.722866e-01 0.012 0 0
G alpha (s) signalling events R-HSA-418555 9.726256e-01 0.012 0 0
Neurotransmitter clearance R-HSA-112311 9.749882e-01 0.011 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.755578e-01 0.011 0 0
Integrin cell surface interactions R-HSA-216083 9.758539e-01 0.011 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.774265e-01 0.010 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.774265e-01 0.010 0 0
Downstream signal transduction R-HSA-186763 9.774265e-01 0.010 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.775365e-01 0.010 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.778024e-01 0.010 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.797568e-01 0.009 0 0
Peptide hormone metabolism R-HSA-2980736 9.800073e-01 0.009 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.808981e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.810940e-01 0.008 0 0
SLC transporter disorders R-HSA-5619102 9.815342e-01 0.008 0 0
Recycling of bile acids and salts R-HSA-159418 9.816137e-01 0.008 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.832238e-01 0.007 0 0
Complex IV assembly R-HSA-9864848 9.833397e-01 0.007 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.834064e-01 0.007 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.838166e-01 0.007 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.846252e-01 0.007 0 0
Potassium Channels R-HSA-1296071 9.846252e-01 0.007 0 0
Signal amplification R-HSA-392518 9.850245e-01 0.007 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.850245e-01 0.007 0 0
Hyaluronan metabolism R-HSA-2142845 9.850245e-01 0.007 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.850245e-01 0.007 0 0
tRNA processing R-HSA-72306 9.851077e-01 0.007 0 0
Extracellular matrix organization R-HSA-1474244 9.863062e-01 0.006 0 0
Formation of the cornified envelope R-HSA-6809371 9.870864e-01 0.006 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.873571e-01 0.006 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.873571e-01 0.006 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.878029e-01 0.005 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.889925e-01 0.005 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.889925e-01 0.005 0 0
Elastic fibre formation R-HSA-1566948 9.900661e-01 0.004 0 0
Dectin-2 family R-HSA-5621480 9.902172e-01 0.004 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.907671e-01 0.004 0 0
Pentose phosphate pathway R-HSA-71336 9.910350e-01 0.004 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.919095e-01 0.004 0 0
Tryptophan catabolism R-HSA-71240 9.919095e-01 0.004 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.919095e-01 0.004 0 0
tRNA Aminoacylation R-HSA-379724 9.925229e-01 0.003 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.926988e-01 0.003 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.927998e-01 0.003 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.933680e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.934111e-01 0.003 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.934111e-01 0.003 0 0
Signaling by PDGF R-HSA-186797 9.937549e-01 0.003 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.938944e-01 0.003 0 0
Activation of GABAB receptors R-HSA-991365 9.940539e-01 0.003 0 0
GABA B receptor activation R-HSA-977444 9.940539e-01 0.003 0 0
Complex I biogenesis R-HSA-6799198 9.942939e-01 0.002 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.943771e-01 0.002 0 0
Surfactant metabolism R-HSA-5683826 9.951576e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.951576e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.956518e-01 0.002 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.957186e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.963750e-01 0.002 0 0
PPARA activates gene expression R-HSA-1989781 9.966348e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.970495e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.970775e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.971022e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.972437e-01 0.001 0 0
Sphingolipid metabolism R-HSA-428157 9.974990e-01 0.001 1 0
Neurotransmitter release cycle R-HSA-112310 9.975653e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.977053e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.978377e-01 0.001 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.980906e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.984716e-01 0.001 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.985520e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.986992e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.987261e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.987691e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.989799e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.990494e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.990640e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.990640e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.990640e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.991332e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.991555e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.992039e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.992784e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.993331e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.993388e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.993538e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.993705e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.996979e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.996979e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.997034e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.997629e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.997698e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998199e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.998674e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.998920e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999545e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999555e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999768e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999829e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999830e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999831e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999862e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999910e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999918e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999930e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999933e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999947e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999956e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999956e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999960e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999984e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999988e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999992e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999992e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999993e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999994e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999995e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999997e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999997e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999999e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways