ULK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Log-Odds: S Sites / S Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A2RUS2 S472 SIGNOR|EPSD|PSP DENND3 KIAA0870 EKRASRKSSHLHVTHRRMVVsMPNLQDIAMPELAPRNssLR
A2RUS2 S490 SIGNOR|EPSD|PSP DENND3 KIAA0870 VVsMPNLQDIAMPELAPRNssLRLTDTAGCRGssAVLNVtP
O00560 S6 EPSD|PSP SDCBP MDA9 SYCL _______________MsLyPsLEDLKVDKVIQAQTAFSANP
O00560 S60 PSP SDCBP MDA9 SYCL PHDGNLyPRLyPELsQyMGLsLNEEEIRANVAVVsGAPLQG
O15027 S846 PSP SEC16A KIAA0310 SEC16 SEC16L PPVLIAQPDHSYNLAQPINFsVSLSNSHEKNQSWREALVGD
O60238 S35 PSP BNIP3L BNIP3A BNIP3H NIX NNNNCEENEQSLPPPAGLNssWVELPMNSSNGNDNGNGKNG
O60260 S108 GPS6|PSP PRKN PARK2 PRNAAGGCEREPQsLTRVDLsssVLPGDSVGLAVILHTDsR
O75143 S355 EPSD|PSP ATG13 KIAA0652 DRTHCAAtPSSSEDTEtVsNssEGRAsPHDVLETIFVRKVG
O75143 S389 PSP ATG13 KIAA0652 IFVRKVGAFVNKPINQVTLTsLDIPFAMFAPKNLELEDTDP
O75385 S317 PSP ULK1 KIAA0722 ssGSGSSSSSSSTSHLASPPsLGEMQQLQKTLAsPADTAGF
P06733 S115 SIGNOR|EPSD|PSP ENO1 ENO1L1 MBPB1 MPB1 IEMDGtENKsKFGANAILGVsLAVCKAGAVEKGVPLyRHIA
P06733 S282 SIGNOR|EPSD|PSP ENO1 ENO1L1 MBPB1 MPB1 KsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDDWG
P08235 S843 PSP NR3C2 MCR MLR NSQFLYFAPDLVFNEEKMHQsAMYELCQGMHQISLQFVRLQ
P08237 S74 SIGNOR|EPSD|PSP PFKM PFKX GYQGLVDGGDHIKEATWESVsMMLQLGGTVIGSARCKDFRE
P08237 S762 SIGNOR|EPSD|PSP PFKM PFKX WLKLRPILKILAKYEIDLDTsDHAHLEHITRKRSGEAAV__
P09467 S63 SIGNOR|EPSD|PSP FBP1 FBP KAISSAVRKAGIAHLYGIAGsTNVTGDQVKKLDVLSNDLVM
P09467 S88 SIGNOR|EPSD|PSP FBP1 FBP GDQVKKLDVLSNDLVMNMLKsSFATCVLVSEEDKHAIIVEP
P19367 S124 SIGNOR|EPSD|PSP HK1 NVHMESEVYDTPENIVHGSGsQLFDHVAECLGDFMEKRKIK
P19367 S364 SIGNOR|EPSD|PSP HK1 KNKEGLHNAKEILTRLGVEPsDDDCVSVQHVCTIVSFRSAN
P46937 S227 SIGNOR|PSP YAP1 YAP65 LSQMNVTAPTsPPVQQNMMNsASGPLPDGWEQAMTQDGEIY
P58004 S254 PSP SESN2 Hi95 SEST2 PSEQSSPPSRDPLNNsGGFEsARDVEALMERMQQLQESLLR
P58004 S73 PSP SESN2 Hi95 SEST2 VLREGAESLEQHLGLEALMSsGRVDNLAVVMGLHPDYFTSF
Q12983 S17 PSP BNIP3 NIP3 ____MSQNGAPGMQEESLQGsWVELHFsNNGNGGSVPAsVS
Q12983 S35 GPS6 BNIP3 NIP3 QGsWVELHFsNNGNGGSVPAsVSIYNGDMEKILLDAQHESG
Q13045 S64 PSP FLII FLIL GLCYLPEELAALQKLEHLSVsHNNLTTLHGELSSLPSLRAI
Q13546 S262 PSP RIPK1 RIP RIP1 KSGNRPDVDDITEYCPREIIsLMKLCWEANPEARPTFPGIE
Q13546 S291 PSP RIPK1 RIP RIP1 NPEARPTFPGIEEKFRPFYLsQLEEsVEEDVKSLKKEYSNE
Q13546 S296 PSP RIPK1 RIP RIP1 PTFPGIEEKFRPFYLsQLEEsVEEDVKSLKKEYSNENAVVK
Q13546 S320 PSP RIPK1 RIP RIP1 DVKSLKKEYSNENAVVKRMQsLQLDCVAVPssRsNsAtEQP
Q13546 S333 PSP RIPK1 RIP RIP1 AVVKRMQsLQLDCVAVPssRsNsAtEQPGSLHssQGLGMGP
Q13546 S335 PSP RIPK1 RIP RIP1 VKRMQsLQLDCVAVPssRsNsAtEQPGSLHssQGLGMGPVE
Q13546 S345 PSP RIPK1 RIP RIP1 CVAVPssRsNsAtEQPGSLHssQGLGMGPVEEsWFAPSLEH
Q13546 S346 PSP RIPK1 RIP RIP1 VAVPssRsNsAtEQPGSLHssQGLGMGPVEEsWFAPSLEHP
Q13546 S357 PSP RIPK1 RIP RIP1 tEQPGSLHssQGLGMGPVEEsWFAPSLEHPQEENEPSLQSK
Q13546 S389 PSP RIPK1 RIP RIP1 ENEPSLQSKLQDEANyHLyGsRMDRQTKQQPRQNVAYNREE
Q13546 T337 PSP RIPK1 RIP RIP1 RMQsLQLDCVAVPssRsNsAtEQPGSLHssQGLGMGPVEEs
Q14457 S15 PSP BECN1 GT197 ______MEGSKTSNNSTMQVsFVCQRCSQPLKLDTsFKILD
Q14457 S279 PSP BECN1 GT197 TQLDKLKKTNVFNATFHIWHsGQFGTINNFRLGRLPsVPVE
Q14457 S30 PSP BECN1 GT197 STMQVsFVCQRCSQPLKLDTsFKILDRVTIQELTAPLLTTA
Q14457 S337 PSP BECN1 GT197 LANKMGLKFQRYRLVPyGNHsYLESLTDKSKELPLyCSGGL
Q14457 S96 PSP BECN1 GT197 DGVSRRFIPPARMMsTEsANsFTLIGEASDGGtMENLSRRL
Q15436 S207 EPSD|PSP SEC23A YVFRGTKDLSAKQLQEMLGLsKVPLTQATRGPQVQQPPPSN
Q15436 T405 EPSD|PSP SEC23A TFQRVFTKDMHGQFKMGFGGtLEIKTSREIKISGAIGPCVS
Q15437 S186 SIGNOR|PSP SEC23B LITFGRMVQVHELSCEGISKsYVFRGTKDLTAKQIQDMLGL
Q16543 S339 EPSD|PSP CDC37 CDC37A DAISKMDPTDAKYHMQRCIDsGLWVPNSKASEAKEGEEAGP
Q676U5 S278 PSP ATG16L1 APG16L UNQ9393/PRO34307 RAISRAATKRLsQPAGGLLDsITNIFGRRsVssFPVPQDNV
Q6ZNE5 S29 PSP ATG14 ATG14L KIAA0831 ARALEAPGCGPRPLARDLVDsVDDAEGLYVAVERCPLCNTT
Q7Z3C6 S14 SIGNOR|EPSD|PSP ATG9A APG9L1 _______MAQFDTEyQRLEAsysDsPPGEEDLLVHVAEGSK
Q7Z3C6 S761 SIGNOR|EPSD|PSP ATG9A APG9L1 sAPDEGGEGARAPQSIPRsAsYPCAAPRPGAPETTALHGGF
Q86WV6 S366 EPSD|PSP STING1 ERIS MITA STING TMEM173 LKTSAVPSTsTMsQEPELLIsGMEKPLPLRTDFS_______
Q8IVP5 S17 SIGNOR|PSP FUNDC1 ____MATRNPPPQDyEsDDDsyEVLDLTEYARRHQWWNRVF
Q8N122 S792 EPSD|PSP RPTOR KIAA1303 RAPTOR PENEEHILSFETIDKMRRAssYSSLNSLIGVSFNSVYTQIW
Q8N122 S855 EPSD|PSP RPTOR KIAA1303 RAPTOR NSIAYKATVNARPQRVLDtssLtQsAPAsPtNKGVHIHQAG
Q8N122 S859 EPSD|PSP RPTOR KIAA1303 RAPTOR YKATVNARPQRVLDtssLtQsAPAsPtNKGVHIHQAGGsPP
Q8N122 S863 PSP RPTOR KIAA1303 RAPTOR VNARPQRVLDtssLtQsAPAsPtNKGVHIHQAGGsPPAsst
Q8N122 S877 PSP RPTOR KIAA1303 RAPTOR tQsAPAsPtNKGVHIHQAGGsPPAsstssssLtNDVAKQPV
Q8NEB9 S249 PSP PIK3C3 VPS34 KEyGIVYYEKDGDEssPILTsFELVKVPDPQMSMENLVESK
Q8NFG4 S406 PSP FLCN BHD SAFEVLRTMLPVGCVRIIPYsSQYEEAYRCNFLGLSPHVQI
Q8NFG4 S537 PSP FLCN BHD VLFKFTKVDSRPKEDTQKLLsILGAsEEDNVKLLKFWMTGL
Q8NFG4 S542 PSP FLCN BHD TKVDSRPKEDTQKLLsILGAsEEDNVKLLKFWMTGLSKTYK
Q8TDY2 S1323 PSP RB1CC1 KIAA0203 RBICC LEQLEEQEKRKNEEMQNVRTsLIAEQQTNFNTVLTREKMRK
Q8TDY2 S943 PSP RB1CC1 KIAA0203 RBICC VICLQNEKDQKLLEMENIMHsQNCEIKELKQSREIVLEDLK
Q8TDY2 S986 PSP RB1CC1 KIAA0203 RBICC HVENDEKLQLLRAELQsLEQsHLKELEDTLQVRHIQEFEKV
Q8TEV9 S400 EPSD|PSP SMCR8 DRMVEKQESIPSKPsQDRPPsssLEECPIPKVLIsVGsYKS
Q8TEV9 S492 EPSD|PSP SMCR8 IEVLGTEKSTSVLsKsDsQAsLtVPLsPQVVRSKAVSHRtI
Q8TEV9 S562 EPSD|PSP SMCR8 NEEESYPDGNEGAIRFQASIsPPELGETEEGSIENTPSQID
Q8TEV9 T666 EPSD|PSP SMCR8 GFPAYELDPSHLLASRDISKtsLDNYSDTTSYVSSVASTSS
Q9BSB4 S11 PSP ATG101 C12orf44 PP894 __________MNCRSEVLEVsVEGRQVEEAMLAVLHTVLLH
Q9BSB4 S203 PSP ATG101 C12orf44 PP894 RDVQPYLYKISFQITDALGTsVTTTMRRLIKDTLAL_____
Q9C0C7 S465 PSP AMBRA1 DCAF3 KIAA1736 VSLLSVLRQQEGGSQASVYTsATEGRGFPASGLATESDGGN
Q9C0C7 S635 PSP AMBRA1 DCAF3 KIAA1736 QLPPLERTEGQTPsSsRLELsssAsPQEERTVGVAFNQETG
Q9Y4P1 S316 EPSD|PSP ATG4B APG4B AUTL1 KIAA0943 DESFHCQHPPCRMSIAELDPsIAVGFFCKTEDDFNDWCQQV
Q9Y6D9 S546 PSP MAD1L1 MAD1 TXBP181 LERRALQGDYDQSRTKVLHMsLNPTSVARQRLREDHSQLQA
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.187939e-14 13.925 0 0
Cell Cycle, Mitotic R-HSA-69278 5.555778e-12 11.255 0 0
Cellular response to heat stress R-HSA-3371556 7.569434e-11 10.121 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.059841e-10 9.686 0 0
Apoptotic execution phase R-HSA-75153 5.428303e-10 9.265 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.596492e-09 8.586 0 0
HSF1-dependent transactivation R-HSA-3371571 3.618309e-09 8.441 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.904204e-09 8.309 0 0
Mitotic Prometaphase R-HSA-68877 7.354602e-09 8.133 0 0
Attenuation phase R-HSA-3371568 1.191056e-08 7.924 0 0
M Phase R-HSA-68886 1.598483e-08 7.796 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.207545e-08 7.376 0 0
HSF1 activation R-HSA-3371511 4.586349e-08 7.339 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.735979e-08 7.325 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.618703e-08 7.179 0 0
Mitotic Anaphase R-HSA-68882 1.258206e-07 6.900 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.450962e-07 6.611 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.368305e-07 6.270 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.368305e-07 6.270 0 0
Signaling by Hippo R-HSA-2028269 1.041201e-06 5.982 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.392975e-06 5.621 0 0
Apoptosis R-HSA-109581 2.564271e-06 5.591 0 0
Separation of Sister Chromatids R-HSA-2467813 3.409769e-06 5.467 0 0
Cellular responses to stimuli R-HSA-8953897 6.379673e-06 5.195 0 0
Signaling by RAS mutants R-HSA-6802949 2.127545e-05 4.672 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.127545e-05 4.672 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.127545e-05 4.672 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.127545e-05 4.672 0 0
Cell Cycle Checkpoints R-HSA-69620 1.968897e-05 4.706 0 0
Programmed Cell Death R-HSA-5357801 2.127420e-05 4.672 0 0
RAF activation R-HSA-5673000 2.179005e-05 4.662 0 0
Signal Transduction R-HSA-162582 3.514430e-05 4.454 1 0
Cellular responses to stress R-HSA-2262752 3.607418e-05 4.443 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.937004e-05 4.226 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.013795e-05 4.221 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.177802e-05 4.209 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.897523e-05 4.004 0 0
PKR-mediated signaling R-HSA-9833482 1.528166e-04 3.816 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.524855e-04 3.817 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.577816e-04 3.802 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.311715e-04 3.636 0 0
G2/M Transition R-HSA-69275 2.244792e-04 3.649 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.474992e-04 3.606 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.752007e-04 3.560 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.275406e-04 3.485 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.205241e-04 3.376 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.586305e-04 3.339 0 0
Neurodegenerative Diseases R-HSA-8863678 4.586305e-04 3.339 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.067197e-04 3.295 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.303795e-04 3.275 0 0
Striated Muscle Contraction R-HSA-390522 5.968023e-04 3.224 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.798058e-04 3.237 0 0
Signaling by ALK in cancer R-HSA-9700206 5.798058e-04 3.237 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.595489e-04 3.181 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.712092e-04 3.173 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.916497e-04 3.160 0 0
Mitotic Prophase R-HSA-68875 8.795644e-04 3.056 0 0
Signaling by VEGF R-HSA-194138 8.901875e-04 3.051 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.458672e-04 3.024 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.746489e-04 3.011 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.711354e-04 3.013 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.003068e-03 2.999 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.034173e-03 2.985 0 0
Post NMDA receptor activation events R-HSA-438064 1.178138e-03 2.929 0 0
Nephrin family interactions R-HSA-373753 1.322577e-03 2.879 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.412203e-03 2.850 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.452764e-03 2.838 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.456964e-03 2.837 0 0
MAP2K and MAPK activation R-HSA-5674135 1.456964e-03 2.837 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.412203e-03 2.850 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.658917e-03 2.780 0 0
Semaphorin interactions R-HSA-373755 1.737464e-03 2.760 0 0
G1/S Transition R-HSA-69206 1.714313e-03 2.766 0 0
Membrane Trafficking R-HSA-199991 1.741027e-03 2.759 1 0
Nuclear import of Rev protein R-HSA-180746 2.169631e-03 2.664 0 0
Nervous system development R-HSA-9675108 2.148229e-03 2.668 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.338613e-03 2.631 0 0
Autophagy R-HSA-9612973 2.379376e-03 2.624 1 0
MITF-M-dependent gene expression R-HSA-9856651 2.430647e-03 2.614 0 0
Aggrephagy R-HSA-9646399 2.623194e-03 2.581 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.623194e-03 2.581 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.722382e-03 2.565 0 0
Axon guidance R-HSA-422475 2.753849e-03 2.560 0 0
Notch-HLH transcription pathway R-HSA-350054 2.969241e-03 2.527 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.937317e-03 2.532 0 0
Macroautophagy R-HSA-1632852 3.050597e-03 2.516 1 1
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.433670e-03 2.464 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.433670e-03 2.464 0 0
The NLRP3 inflammasome R-HSA-844456 3.438375e-03 2.464 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.786122e-03 2.422 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.975940e-03 2.401 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.175753e-03 2.379 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.686274e-03 2.329 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.830025e-03 2.316 0 0
Interleukin-12 signaling R-HSA-9020591 4.866848e-03 2.313 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.181507e-03 2.286 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.654769e-03 2.248 0 0
Selective autophagy R-HSA-9663891 5.654769e-03 2.248 1 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.588074e-03 2.253 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.947571e-03 2.226 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.947571e-03 2.226 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.947571e-03 2.226 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.962099e-03 2.225 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 6.388109e-03 2.195 0 0
IKBKB deficiency causes SCID R-HSA-5602636 6.388109e-03 2.195 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.151284e-03 2.211 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.151284e-03 2.211 0 0
MAPK family signaling cascades R-HSA-5683057 6.526454e-03 2.185 0 0
Muscle contraction R-HSA-397014 6.671304e-03 2.176 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.679717e-03 2.175 0 0
Downstream signal transduction R-HSA-186763 7.232514e-03 2.141 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 7.232514e-03 2.141 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 7.232514e-03 2.141 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.903909e-03 2.161 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.895633e-03 2.161 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.208088e-03 2.142 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 7.208088e-03 2.142 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.273996e-03 2.138 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.338098e-03 2.134 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.805424e-03 2.108 0 0
FLT3 Signaling R-HSA-9607240 7.805424e-03 2.108 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.898051e-03 2.102 1 1
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.518419e-03 2.070 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.518419e-03 2.070 0 0
Host Interactions of HIV factors R-HSA-162909 8.579155e-03 2.067 0 0
Diseases of DNA repair R-HSA-9675135 8.465809e-03 2.072 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 8.587852e-03 2.066 0 0
SOS-mediated signalling R-HSA-112412 8.587852e-03 2.066 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.643481e-03 2.063 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.967206e-03 2.047 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.035045e-03 2.044 0 0
ESR-mediated signaling R-HSA-8939211 9.274341e-03 2.033 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.018632e-02 1.992 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.018632e-02 1.992 0 0
EPH-Ephrin signaling R-HSA-2682334 9.722461e-03 2.012 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.018632e-02 1.992 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 9.591404e-03 2.018 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.607180e-03 2.017 0 0
Interleukin-12 family signaling R-HSA-447115 9.815064e-03 2.008 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.039862e-02 1.983 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.039862e-02 1.983 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.093977e-02 1.961 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.093977e-02 1.961 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.109001e-02 1.955 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.130917e-02 1.947 0 0
HIV Infection R-HSA-162906 1.156367e-02 1.937 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.233456e-02 1.909 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.365801e-02 1.865 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.365801e-02 1.865 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.365801e-02 1.865 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.365801e-02 1.865 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.345701e-02 1.871 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.345701e-02 1.871 0 0
Meiosis R-HSA-1500620 1.357899e-02 1.867 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.365801e-02 1.865 0 0
HIV Life Cycle R-HSA-162587 1.265938e-02 1.898 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.379928e-02 1.860 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.379928e-02 1.860 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.383584e-02 1.859 0 0
Rab regulation of trafficking R-HSA-9007101 1.410161e-02 1.851 1 0
MET activates RAS signaling R-HSA-8851805 1.549835e-02 1.810 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.563201e-02 1.806 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.640372e-02 1.785 0 0
Nucleosome assembly R-HSA-774815 1.640372e-02 1.785 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.588236e-02 1.799 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.539965e-02 1.812 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.540099e-02 1.812 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.549835e-02 1.810 0 0
Activation of BH3-only proteins R-HSA-114452 1.553444e-02 1.809 0 0
Centrosome maturation R-HSA-380287 1.714129e-02 1.766 0 0
Signaling by PTK6 R-HSA-8848021 1.730706e-02 1.762 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.730706e-02 1.762 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 1.753861e-02 1.756 0 0
ALK mutants bind TKIs R-HSA-9700645 1.753861e-02 1.756 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.809139e-02 1.743 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.809139e-02 1.743 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.809139e-02 1.743 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.809139e-02 1.743 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.809139e-02 1.743 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.871268e-02 1.728 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.876151e-02 1.727 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.876151e-02 1.727 0 0
snRNP Assembly R-HSA-191859 2.175533e-02 1.662 0 0
Metabolism of non-coding RNA R-HSA-194441 2.175533e-02 1.662 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.132880e-02 1.671 0 0
G0 and Early G1 R-HSA-1538133 2.156074e-02 1.666 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.051974e-02 1.688 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.937321e-02 1.713 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.979837e-02 1.703 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.015798e-02 1.696 0 0
Glycolysis R-HSA-70171 2.274481e-02 1.643 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.579552e-02 1.588 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.579552e-02 1.588 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.579552e-02 1.588 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.579552e-02 1.588 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.579552e-02 1.588 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.579552e-02 1.588 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.579552e-02 1.588 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.372201e-02 1.625 0 0
Translation initiation complex formation R-HSA-72649 2.440549e-02 1.613 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.412198e-02 1.618 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.442659e-02 1.612 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.514045e-02 1.600 0 0
Polo-like kinase mediated events R-HSA-156711 2.571557e-02 1.590 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.477400e-02 1.606 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.481926e-02 1.605 0 0
Regulation of CDH11 function R-HSA-9762292 2.372201e-02 1.625 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.372201e-02 1.625 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.372201e-02 1.625 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.568700e-02 1.590 0 0
MTOR signalling R-HSA-165159 2.375894e-02 1.624 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.375755e-02 1.624 0 0
Kinesins R-HSA-983189 2.435178e-02 1.613 0 0
Cell-Cell communication R-HSA-1500931 2.342287e-02 1.630 0 0
Regulation of TP53 Activity R-HSA-5633007 2.489690e-02 1.604 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.571557e-02 1.590 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.655634e-02 1.576 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.657649e-02 1.576 0 0
Signaling by SCF-KIT R-HSA-1433557 2.705689e-02 1.568 0 0
MAP kinase activation R-HSA-450294 2.717314e-02 1.566 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.736931e-02 1.563 0 0
Inflammasomes R-HSA-622312 2.739576e-02 1.562 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.741024e-02 1.562 0 0
S Phase R-HSA-69242 2.741024e-02 1.562 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.813850e-02 1.551 0 0
Erythropoietin activates RAS R-HSA-9027284 3.214139e-02 1.493 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.214139e-02 1.493 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.202300e-02 1.495 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.062251e-02 1.514 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.353160e-02 1.475 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.353160e-02 1.475 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.912785e-02 1.536 0 0
G2/M Checkpoints R-HSA-69481 3.316838e-02 1.479 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.875553e-02 1.541 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.214139e-02 1.493 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.127614e-02 1.505 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.302327e-02 1.481 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.302327e-02 1.481 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.302327e-02 1.481 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.142337e-02 1.503 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.214139e-02 1.493 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.214139e-02 1.493 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.875553e-02 1.541 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.016317e-02 1.521 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.192209e-02 1.496 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.354380e-02 1.474 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.354380e-02 1.474 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.462981e-02 1.461 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.492146e-02 1.457 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.557464e-02 1.449 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.611902e-02 1.442 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.611902e-02 1.442 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.656777e-02 1.437 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.758975e-02 1.425 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.758975e-02 1.425 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.758975e-02 1.425 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.892980e-02 1.410 0 0
Dopamine receptors R-HSA-390651 3.905828e-02 1.408 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 3.905828e-02 1.408 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 3.905828e-02 1.408 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 3.905828e-02 1.408 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.905828e-02 1.408 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.932232e-02 1.405 0 0
Activation of RAC1 R-HSA-428540 3.991037e-02 1.399 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.991037e-02 1.399 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.991037e-02 1.399 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.043356e-02 1.393 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.094321e-02 1.388 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.094321e-02 1.388 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.107117e-02 1.386 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.875047e-02 1.312 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.001324e-02 1.301 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.001324e-02 1.301 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.001324e-02 1.301 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.001324e-02 1.301 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.001324e-02 1.301 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.799747e-02 1.319 0 0
mRNA Splicing R-HSA-72172 4.886605e-02 1.311 0 0
Co-stimulation by CD28 R-HSA-389356 4.863902e-02 1.313 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.937677e-02 1.306 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.875047e-02 1.312 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.001324e-02 1.301 0 0
Interferon Signaling R-HSA-913531 4.985737e-02 1.302 0 0
Ca-dependent events R-HSA-111996 4.932882e-02 1.307 0 0
Calmodulin induced events R-HSA-111933 4.373664e-02 1.359 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.504857e-02 1.346 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.001324e-02 1.301 0 0
CaM pathway R-HSA-111997 4.373664e-02 1.359 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.504857e-02 1.346 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.975044e-02 1.303 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.631943e-02 1.334 0 0
Activation of RAS in B cells R-HSA-1169092 4.875047e-02 1.312 0 0
G1/S-Specific Transcription R-HSA-69205 4.373664e-02 1.359 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.001324e-02 1.301 0 0
Opioid Signalling R-HSA-111885 5.227138e-02 1.282 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.259200e-02 1.279 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.259200e-02 1.279 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 5.358202e-02 1.271 0 0
Manipulation of host energy metabolism R-HSA-9636667 5.358202e-02 1.271 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.358202e-02 1.271 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.424206e-02 1.266 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.496198e-02 1.260 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.496198e-02 1.260 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.505681e-02 1.259 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.505681e-02 1.259 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.585028e-02 1.253 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.588535e-02 1.253 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.588535e-02 1.253 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.609083e-02 1.251 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.677805e-02 1.246 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.677805e-02 1.246 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.677805e-02 1.246 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.677805e-02 1.246 0 0
Cellular Senescence R-HSA-2559583 5.743207e-02 1.241 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.745646e-02 1.241 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.745646e-02 1.241 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 5.745646e-02 1.241 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.745646e-02 1.241 0 0
NRAGE signals death through JNK R-HSA-193648 5.806018e-02 1.236 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.806018e-02 1.236 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 6.290122e-02 1.201 0 0
CASP8 activity is inhibited R-HSA-5218900 6.290122e-02 1.201 0 0
Late endosomal microautophagy R-HSA-9615710 7.171523e-02 1.144 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.988147e-02 1.223 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.272868e-02 1.138 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.600351e-02 1.180 0 0
Homology Directed Repair R-HSA-5693538 6.600351e-02 1.180 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.023432e-02 1.153 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.966070e-02 1.157 0 0
Interleukin-6 signaling R-HSA-1059683 6.148397e-02 1.211 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.148397e-02 1.211 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.790496e-02 1.168 0 0
Intracellular signaling by second messengers R-HSA-9006925 7.039944e-02 1.152 0 0
DAG and IP3 signaling R-HSA-1489509 6.819946e-02 1.166 0 0
DARPP-32 events R-HSA-180024 7.171523e-02 1.144 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.125327e-02 1.147 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 7.431763e-02 1.129 0 0
Death Receptor Signaling R-HSA-73887 6.052927e-02 1.218 1 0
Cytokine Signaling in Immune system R-HSA-1280215 7.143372e-02 1.146 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.171523e-02 1.144 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.132157e-02 1.212 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 6.795487e-02 1.168 0 0
Interleukin-17 signaling R-HSA-448424 6.425512e-02 1.192 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.795487e-02 1.168 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.431763e-02 1.129 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.442601e-02 1.191 0 0
Glucose metabolism R-HSA-70326 6.191720e-02 1.208 0 0
Signaling by NTRKs R-HSA-166520 6.390249e-02 1.194 0 0
Transport of connexons to the plasma membrane R-HSA-190872 6.795487e-02 1.168 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.425512e-02 1.192 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 7.532881e-02 1.123 0 0
Chromatin organization R-HSA-4839726 7.545997e-02 1.122 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.569529e-02 1.121 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 7.763607e-02 1.110 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 7.763607e-02 1.110 0 0
2-LTR circle formation R-HSA-164843 7.896851e-02 1.103 0 0
Chromosome Maintenance R-HSA-73886 7.937232e-02 1.100 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.976893e-02 1.098 0 0
Meiotic synapsis R-HSA-1221632 7.976893e-02 1.098 0 0
Smooth Muscle Contraction R-HSA-445355 7.976893e-02 1.098 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.983009e-02 1.098 0 0
Signalling to ERKs R-HSA-187687 7.983009e-02 1.098 0 0
Interleukin-37 signaling R-HSA-9008059 8.113725e-02 1.091 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.128648e-02 1.090 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.128648e-02 1.090 0 0
Recycling pathway of L1 R-HSA-437239 8.305593e-02 1.081 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.329482e-02 1.079 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.329482e-02 1.079 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.329482e-02 1.079 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.329482e-02 1.079 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.329482e-02 1.079 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 1.159226e-01 0.936 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.159226e-01 0.936 0 0
Defective OGG1 Localization R-HSA-9657050 1.159226e-01 0.936 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.801770e-02 1.055 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.801770e-02 1.055 0 0
Regulation of cortical dendrite branching R-HSA-8985801 8.801770e-02 1.055 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 8.801770e-02 1.055 0 0
Signalling to ERK5 R-HSA-198765 8.801770e-02 1.055 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 8.801770e-02 1.055 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.801770e-02 1.055 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.801770e-02 1.055 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.801770e-02 1.055 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.801770e-02 1.055 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.801770e-02 1.055 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 8.801770e-02 1.055 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.801770e-02 1.055 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.801770e-02 1.055 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.801770e-02 1.055 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 8.801770e-02 1.055 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.801770e-02 1.055 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.013243e-01 0.994 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.013243e-01 0.994 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.013243e-01 0.994 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 9.686429e-02 1.014 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 9.686429e-02 1.014 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 9.686429e-02 1.014 0 0
ERKs are inactivated R-HSA-202670 1.164706e-01 0.934 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.848969e-02 1.053 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.848969e-02 1.053 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 1.039577e-01 0.983 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.039577e-01 0.983 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.125712e-02 1.040 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 9.117968e-02 1.040 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.056277e-01 0.976 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.056277e-01 0.976 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.045742e-01 0.981 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.091441e-01 0.962 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.056277e-01 0.976 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.135644e-01 0.945 0 0
Integrin signaling R-HSA-354192 1.135644e-01 0.945 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.013243e-01 0.994 0 0
Integration of provirus R-HSA-162592 1.164706e-01 0.934 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.163416e-01 0.934 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.432896e-02 1.025 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 9.877885e-02 1.005 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.144118e-01 0.942 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.013243e-01 0.994 0 0
Long-term potentiation R-HSA-9620244 9.251987e-02 1.034 0 0
Signaling by WNT in cancer R-HSA-4791275 1.020695e-01 0.991 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.084433e-01 0.965 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.205731e-02 1.036 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.135644e-01 0.945 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.507558e-02 1.022 0 0
DNA Repair R-HSA-73894 1.018926e-01 0.992 0 0
Toll-like Receptor Cascades R-HSA-168898 9.813633e-02 1.008 0 0
Prolonged ERK activation events R-HSA-169893 1.039577e-01 0.983 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.045742e-01 0.981 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.629931e-02 1.016 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.135644e-01 0.945 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 8.801770e-02 1.055 0 0
Signaling by APC mutants R-HSA-4839744 9.686429e-02 1.014 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.164706e-01 0.934 0 0
Signaling by AXIN mutants R-HSA-4839735 1.164706e-01 0.934 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.848969e-02 1.053 0 0
Signaling by NOTCH1 R-HSA-1980143 1.023622e-01 0.990 0 0
FLT3 signaling in disease R-HSA-9682385 8.900582e-02 1.051 0 0
PI Metabolism R-HSA-1483255 1.123227e-01 0.950 0 0
tRNA processing in the nucleus R-HSA-6784531 9.816396e-02 1.008 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 9.341312e-02 1.030 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.013243e-01 0.994 0 0
L1CAM interactions R-HSA-373760 8.908367e-02 1.050 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.848969e-02 1.053 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.848969e-02 1.053 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 9.686429e-02 1.014 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.164706e-01 0.934 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.174315e-01 0.930 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.174315e-01 0.930 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.174315e-01 0.930 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.174315e-01 0.930 0 0
G alpha (12/13) signalling events R-HSA-416482 1.176098e-01 0.930 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.200930e-01 0.920 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.206633e-01 0.918 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.206633e-01 0.918 0 0
Disorders of Developmental Biology R-HSA-9675151 1.206633e-01 0.918 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.206633e-01 0.918 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.247570e-01 0.904 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.247570e-01 0.904 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.264186e-01 0.898 0 0
MET activates PTPN11 R-HSA-8865999 1.271891e-01 0.896 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.271891e-01 0.896 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.274877e-01 0.895 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.274877e-01 0.895 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.274877e-01 0.895 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.274877e-01 0.895 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 1.274877e-01 0.895 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.274877e-01 0.895 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.282916e-01 0.892 0 0
Signaling by Interleukins R-HSA-449147 1.293747e-01 0.888 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.307418e-01 0.884 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.307418e-01 0.884 0 0
Insulin receptor recycling R-HSA-77387 1.310673e-01 0.883 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.310673e-01 0.883 0 0
HIV Transcription Elongation R-HSA-167169 1.316137e-01 0.881 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.316137e-01 0.881 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.316137e-01 0.881 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.316137e-01 0.881 0 0
Diseases of Immune System R-HSA-5260271 1.316137e-01 0.881 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 1.316137e-01 0.881 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.324264e-01 0.878 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.335119e-01 0.874 0 0
Signaling by Insulin receptor R-HSA-74752 1.342742e-01 0.872 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.343521e-01 0.872 0 0
Metabolism of RNA R-HSA-8953854 1.353397e-01 0.869 0 0
mTORC1-mediated signalling R-HSA-166208 1.356481e-01 0.868 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 1.356481e-01 0.868 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.356481e-01 0.868 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.356481e-01 0.868 0 0
Signaling by KIT in disease R-HSA-9669938 1.356481e-01 0.868 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.357851e-01 0.867 1 1
IRAK1 recruits IKK complex R-HSA-937039 1.376460e-01 0.861 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.376460e-01 0.861 0 0
Regulation of IFNG signaling R-HSA-877312 1.376460e-01 0.861 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.376460e-01 0.861 0 0
Pervasive developmental disorders R-HSA-9005895 1.376460e-01 0.861 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.376460e-01 0.861 0 0
Disorders of Nervous System Development R-HSA-9697154 1.376460e-01 0.861 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.376460e-01 0.861 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.385344e-01 0.858 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.385388e-01 0.858 0 0
DNA Double Strand Break Response R-HSA-5693606 1.419161e-01 0.848 0 0
G-protein mediated events R-HSA-112040 1.419161e-01 0.848 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.428449e-01 0.845 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.428449e-01 0.845 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.695367e-01 0.771 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.695367e-01 0.771 0 0
IRS activation R-HSA-74713 2.137987e-01 0.670 0 0
Activation of AKT2 R-HSA-165158 2.137987e-01 0.670 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.137987e-01 0.670 0 0
Suppression of autophagy R-HSA-9636569 2.137987e-01 0.670 0 0
Type I hemidesmosome assembly R-HSA-446107 1.557483e-01 0.808 0 0
Regulation by c-FLIP R-HSA-3371378 1.557483e-01 0.808 0 0
Dimerization of procaspase-8 R-HSA-69416 1.557483e-01 0.808 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.557483e-01 0.808 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.557483e-01 0.808 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.857230e-01 0.731 0 0
ARMS-mediated activation R-HSA-170984 1.857230e-01 0.731 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.857230e-01 0.731 0 0
MAPK1 (ERK2) activation R-HSA-112411 1.857230e-01 0.731 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.602317e-01 0.795 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.602317e-01 0.795 0 0
MAPK3 (ERK1) activation R-HSA-110056 2.170365e-01 0.663 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.089450e-01 0.680 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.089450e-01 0.680 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.089450e-01 0.680 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.454517e-01 0.837 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.691964e-01 0.772 0 0
Trafficking of AMPA receptors R-HSA-399719 1.763202e-01 0.754 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.058049e-01 0.687 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.927200e-01 0.715 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.517636e-01 0.819 0 0
Neutrophil degranulation R-HSA-6798695 1.570399e-01 0.804 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.605493e-01 0.794 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.114055e-01 0.675 0 0
Activation of the pre-replicative complex R-HSA-68962 1.605493e-01 0.794 0 0
Signaling by EGFR R-HSA-177929 1.724824e-01 0.763 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.574873e-01 0.803 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.097013e-01 0.678 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.853608e-01 0.732 0 0
p75NTR signals via NF-kB R-HSA-193639 2.089450e-01 0.680 0 0
DCC mediated attractive signaling R-HSA-418885 2.089450e-01 0.680 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.691964e-01 0.772 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.745897e-01 0.758 0 0
Meiotic recombination R-HSA-912446 1.974711e-01 0.704 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.037798e-01 0.691 0 0
Interleukin-6 family signaling R-HSA-6783589 1.691964e-01 0.772 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.520083e-01 0.818 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.037798e-01 0.691 0 0
Neurexins and neuroligins R-HSA-6794361 2.110790e-01 0.676 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.006565e-01 0.698 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.520083e-01 0.818 0 0
Signaling by ROBO receptors R-HSA-376176 2.088301e-01 0.680 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.557483e-01 0.808 0 0
Calcineurin activates NFAT R-HSA-2025928 1.857230e-01 0.731 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.170365e-01 0.663 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.840572e-01 0.735 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.605493e-01 0.794 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.763202e-01 0.754 0 0
PLC beta mediated events R-HSA-112043 1.509884e-01 0.821 0 0
Vesicle-mediated transport R-HSA-5653656 1.965826e-01 0.706 1 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.605493e-01 0.794 0 0
Regulation of CDH1 Function R-HSA-9764561 1.845524e-01 0.734 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.772427e-01 0.751 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.454517e-01 0.837 0 0
Protein methylation R-HSA-8876725 2.089450e-01 0.680 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.691964e-01 0.772 0 0
Chromatin modifying enzymes R-HSA-3247509 1.729973e-01 0.762 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.142008e-01 0.669 0 0
Cellular response to chemical stress R-HSA-9711123 1.540359e-01 0.812 0 0
Cell junction organization R-HSA-446728 1.669262e-01 0.777 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.454517e-01 0.837 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.137987e-01 0.670 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.574873e-01 0.803 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.509884e-01 0.821 0 0
Interleukin-1 family signaling R-HSA-446652 2.131673e-01 0.671 0 0
Frs2-mediated activation R-HSA-170968 1.602317e-01 0.795 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.563079e-01 0.806 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.097013e-01 0.678 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.833674e-01 0.737 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.170365e-01 0.663 0 0
p38MAPK events R-HSA-171007 2.089450e-01 0.680 0 0
Heme signaling R-HSA-9707616 1.616909e-01 0.791 0 0
Reproduction R-HSA-1474165 1.991320e-01 0.701 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.149078e-01 0.668 0 0
Platelet sensitization by LDL R-HSA-432142 1.574873e-01 0.803 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.495414e-01 0.825 0 0
NrCAM interactions R-HSA-447038 2.137987e-01 0.670 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 1.857230e-01 0.731 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.137987e-01 0.670 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.454517e-01 0.837 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.708086e-01 0.767 0 0
Tie2 Signaling R-HSA-210993 1.574873e-01 0.803 0 0
Regulation of beta-cell development R-HSA-186712 2.098077e-01 0.678 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 1.574873e-01 0.803 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.840572e-01 0.735 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.178325e-01 0.662 0 0
Signaling by NOTCH4 R-HSA-9013694 2.178325e-01 0.662 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.184132e-01 0.661 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 2.184132e-01 0.661 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.184132e-01 0.661 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.184132e-01 0.661 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.184132e-01 0.661 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.184132e-01 0.661 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.184132e-01 0.661 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.184132e-01 0.661 0 0
TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3642279 2.184132e-01 0.661 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.184132e-01 0.661 0 0
Blockage of phagosome acidification R-HSA-9636467 2.184132e-01 0.661 0 0
Defective MOGS causes CDG-2b R-HSA-4793954 2.184132e-01 0.661 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.184132e-01 0.661 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 2.184132e-01 0.661 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.184132e-01 0.661 0 0
Inhibition of PKR R-HSA-169131 2.184132e-01 0.661 0 0
ERK/MAPK targets R-HSA-198753 2.198746e-01 0.658 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.202049e-01 0.657 0 0
Gene Silencing by RNA R-HSA-211000 2.224450e-01 0.653 0 0
Signaling by ERBB2 R-HSA-1227986 2.229554e-01 0.652 0 0
Diseases of programmed cell death R-HSA-9645723 2.230092e-01 0.652 0 0
Cilium Assembly R-HSA-5617833 2.240606e-01 0.650 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.248523e-01 0.648 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.250883e-01 0.648 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.250883e-01 0.648 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.250883e-01 0.648 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.260249e-01 0.646 0 0
Interleukin-1 signaling R-HSA-9020702 2.263090e-01 0.645 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 2.266596e-01 0.645 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 2.266596e-01 0.645 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.272134e-01 0.644 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.298959e-01 0.638 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 3.090273e-01 0.510 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.090273e-01 0.510 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.090273e-01 0.510 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.090273e-01 0.510 0 0
Defective APRT disrupts adenine salvage R-HSA-9734195 3.090273e-01 0.510 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.090273e-01 0.510 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.090273e-01 0.510 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.090273e-01 0.510 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.090273e-01 0.510 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.090273e-01 0.510 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.090273e-01 0.510 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.090273e-01 0.510 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.589627e-01 0.587 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.589627e-01 0.587 0 0
Phosphorylation of Emi1 R-HSA-176417 2.589627e-01 0.587 0 0
Signaling by MAPK mutants R-HSA-9652817 2.589627e-01 0.587 0 0
Signaling by RNF43 mutants R-HSA-5340588 2.589627e-01 0.587 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.891407e-01 0.410 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.891407e-01 0.410 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.891407e-01 0.410 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.891407e-01 0.410 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 3.891407e-01 0.410 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 3.891407e-01 0.410 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.891407e-01 0.410 0 0
Potassium transport channels R-HSA-1296067 3.891407e-01 0.410 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.891407e-01 0.410 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.042253e-01 0.517 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.042253e-01 0.517 0 0
STAT5 Activation R-HSA-9645135 3.042253e-01 0.517 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.347152e-01 0.629 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.347152e-01 0.629 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.822725e-01 0.549 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.489570e-01 0.457 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.489570e-01 0.457 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.489570e-01 0.457 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.599697e-01 0.337 0 0
MET interacts with TNS proteins R-HSA-8875513 4.599697e-01 0.337 0 0
Axonal growth stimulation R-HSA-209563 4.599697e-01 0.337 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.599697e-01 0.337 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.599697e-01 0.337 0 0
Classical Kir channels R-HSA-1296053 4.599697e-01 0.337 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.599697e-01 0.337 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.599697e-01 0.337 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.599697e-01 0.337 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.881916e-01 0.540 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.926728e-01 0.406 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.926728e-01 0.406 0 0
RSK activation R-HSA-444257 3.926728e-01 0.406 0 0
MET receptor recycling R-HSA-8875656 3.926728e-01 0.406 0 0
Co-stimulation by ICOS R-HSA-9927354 3.926728e-01 0.406 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.926728e-01 0.406 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.449281e-01 0.611 0 0
HIV elongation arrest and recovery R-HSA-167287 2.449281e-01 0.611 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.449281e-01 0.611 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.449281e-01 0.611 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.489013e-01 0.457 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.155551e-01 0.501 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.883328e-01 0.540 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.883328e-01 0.540 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.883328e-01 0.540 0 0
Signaling by Erythropoietin R-HSA-9006335 2.652493e-01 0.576 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.652493e-01 0.576 0 0
Translesion Synthesis by POLH R-HSA-110320 3.431201e-01 0.465 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.820673e-01 0.418 0 0
Lipophagy R-HSA-9613354 4.350072e-01 0.362 0 0
Interleukin-21 signaling R-HSA-9020958 4.350072e-01 0.362 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 4.350072e-01 0.362 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 4.350072e-01 0.362 0 0
RET signaling R-HSA-8853659 2.823984e-01 0.549 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.982688e-01 0.400 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.840341e-01 0.416 0 0
mRNA 3'-end processing R-HSA-72187 3.231600e-01 0.491 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.231600e-01 0.491 0 0
Phosphorylation of the APC/C R-HSA-176412 4.470296e-01 0.350 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.522667e-01 0.598 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.496727e-01 0.456 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.255878e-01 0.371 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.400522e-01 0.468 0 0
Dual Incision in GG-NER R-HSA-5696400 3.930832e-01 0.406 0 0
Intra-Golgi traffic R-HSA-6811438 3.996709e-01 0.398 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.149406e-01 0.502 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.362296e-01 0.360 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.835565e-01 0.416 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.556945e-01 0.341 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.624910e-01 0.441 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.624910e-01 0.441 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.258605e-01 0.371 0 0
Dual incision in TC-NER R-HSA-6782135 4.258605e-01 0.371 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.453052e-01 0.351 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.335649e-01 0.363 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.730508e-01 0.564 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.835565e-01 0.416 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.835565e-01 0.416 0 0
G1 Phase R-HSA-69236 3.135195e-01 0.504 0 0
Cyclin D associated events in G1 R-HSA-69231 3.135195e-01 0.504 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.364228e-01 0.626 0 0
DNA Damage Bypass R-HSA-73893 2.736580e-01 0.563 0 0
mRNA Capping R-HSA-72086 4.319922e-01 0.365 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.064398e-01 0.514 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 2.822725e-01 0.549 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.155546e-01 0.501 0 0
IRS-mediated signalling R-HSA-112399 2.841747e-01 0.546 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.418608e-01 0.466 0 0
Interferon alpha/beta signaling R-HSA-909733 4.234474e-01 0.373 0 0
G-protein beta:gamma signalling R-HSA-397795 3.498377e-01 0.456 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.798543e-01 0.420 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.418608e-01 0.466 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.867113e-01 0.543 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.859763e-01 0.544 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.419899e-01 0.616 0 0
GAB1 signalosome R-HSA-180292 3.155551e-01 0.501 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.315150e-01 0.479 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.449281e-01 0.611 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.489570e-01 0.457 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.881916e-01 0.540 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.820673e-01 0.418 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.350072e-01 0.362 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 4.525804e-01 0.344 0 0
TNF signaling R-HSA-75893 2.689709e-01 0.570 1 0
Signal amplification R-HSA-392518 3.930832e-01 0.406 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.471473e-01 0.350 0 0
RNA Polymerase I Transcription R-HSA-73864 3.724721e-01 0.429 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.155546e-01 0.501 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.820673e-01 0.418 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.199756e-01 0.377 0 0
Interleukin-9 signaling R-HSA-8985947 3.926728e-01 0.406 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.503462e-01 0.601 0 0
RAS processing R-HSA-9648002 3.403849e-01 0.468 0 0
Insulin receptor signalling cascade R-HSA-74751 2.785208e-01 0.555 0 0
GPVI-mediated activation cascade R-HSA-114604 4.362296e-01 0.360 0 0
NF-kB is activated and signals survival R-HSA-209560 2.822725e-01 0.549 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.926728e-01 0.406 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.362296e-01 0.360 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.681920e-01 0.434 0 0
TCR signaling R-HSA-202403 3.385240e-01 0.470 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.347152e-01 0.629 0 0
Ephrin signaling R-HSA-3928664 3.155551e-01 0.501 0 0
Myogenesis R-HSA-525793 3.599431e-01 0.444 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.742101e-01 0.427 0 0
Ion homeostasis R-HSA-5578775 2.689709e-01 0.570 0 0
IGF1R signaling cascade R-HSA-2428924 2.785208e-01 0.555 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.668974e-01 0.574 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.419899e-01 0.616 0 0
Interleukin-7 signaling R-HSA-1266695 3.358973e-01 0.474 0 0
Signaling by PDGF R-HSA-186797 2.501880e-01 0.602 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.822725e-01 0.549 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.489570e-01 0.457 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.097970e-01 0.387 0 0
Mitophagy R-HSA-5205647 3.930832e-01 0.406 1 0
Signaling by NOTCH3 R-HSA-9012852 3.742101e-01 0.427 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.576112e-01 0.340 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 2.881916e-01 0.540 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.930410e-01 0.533 0 0
Oncogene Induced Senescence R-HSA-2559585 4.147006e-01 0.382 0 0
Platelet calcium homeostasis R-HSA-418360 4.319922e-01 0.365 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 4.194737e-01 0.377 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.220367e-01 0.492 0 0
Circadian clock R-HSA-9909396 2.875700e-01 0.541 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.347152e-01 0.629 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.881916e-01 0.540 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 4.255878e-01 0.371 0 0
Hedgehog 'off' state R-HSA-5610787 3.951431e-01 0.403 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.807284e-01 0.552 0 0
Mismatch Repair R-HSA-5358508 3.155551e-01 0.501 0 0
DAP12 signaling R-HSA-2424491 4.556945e-01 0.341 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.470522e-01 0.460 0 0
Intraflagellar transport R-HSA-5620924 3.863013e-01 0.413 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.621542e-01 0.441 0 0
Gene expression (Transcription) R-HSA-74160 4.073084e-01 0.390 0 0
NGF-stimulated transcription R-HSA-9031628 2.576673e-01 0.589 0 0
Regulated Necrosis R-HSA-5218859 2.332312e-01 0.632 0 0
Signaling by NOTCH R-HSA-157118 3.867275e-01 0.413 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.881916e-01 0.540 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 4.350072e-01 0.362 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.835565e-01 0.416 0 0
Transmission across Chemical Synapses R-HSA-112315 4.142360e-01 0.383 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.599431e-01 0.444 0 0
Ion transport by P-type ATPases R-HSA-936837 2.785208e-01 0.555 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.957299e-01 0.529 0 0
Signaling by FGFR4 R-HSA-5654743 2.957299e-01 0.529 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.090273e-01 0.510 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.891407e-01 0.410 0 0
C6 deamination of adenosine R-HSA-75102 3.891407e-01 0.410 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 3.891407e-01 0.410 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.489570e-01 0.457 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.489570e-01 0.457 0 0
MET activates STAT3 R-HSA-8875791 4.599697e-01 0.337 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.599697e-01 0.337 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 3.489013e-01 0.457 0 0
Unwinding of DNA R-HSA-176974 4.350072e-01 0.362 0 0
Budding and maturation of HIV virion R-HSA-162588 3.070331e-01 0.513 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.501880e-01 0.602 0 0
RMTs methylate histone arginines R-HSA-3214858 3.135195e-01 0.504 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 4.470296e-01 0.350 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.080790e-01 0.389 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.798543e-01 0.420 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.194737e-01 0.377 0 0
TBC/RABGAPs R-HSA-8854214 4.392144e-01 0.357 1 1
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.097815e-01 0.387 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.408659e-01 0.467 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.408659e-01 0.467 0 0
Signaling by FGFR3 R-HSA-5654741 3.315150e-01 0.479 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.623457e-01 0.581 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.798543e-01 0.420 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 2.421647e-01 0.616 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 2.650206e-01 0.577 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 3.358973e-01 0.474 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 4.080790e-01 0.389 0 0
Signaling by TGFB family members R-HSA-9006936 2.823054e-01 0.549 0 0
RUNX2 regulates bone development R-HSA-8941326 4.362296e-01 0.360 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.498377e-01 0.456 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.258605e-01 0.371 0 0
MHC class II antigen presentation R-HSA-2132295 2.532037e-01 0.597 0 0
Gap junction trafficking and regulation R-HSA-157858 4.046879e-01 0.393 0 0
Nef and signal transduction R-HSA-164944 3.042253e-01 0.517 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.489570e-01 0.457 0 0
Signal regulatory protein family interactions R-HSA-391160 3.820673e-01 0.418 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.350072e-01 0.362 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.350072e-01 0.362 0 0
Degradation of CDH1 R-HSA-9766229 4.046879e-01 0.393 0 0
Ion channel transport R-HSA-983712 2.765985e-01 0.558 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.859763e-01 0.544 0 0
Gap junction trafficking R-HSA-190828 4.588466e-01 0.338 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.319922e-01 0.365 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.556945e-01 0.341 0 0
TRAIL signaling R-HSA-75158 2.589627e-01 0.587 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.822725e-01 0.549 0 0
Intracellular oxygen transport R-HSA-8981607 4.599697e-01 0.337 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.881916e-01 0.540 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.926728e-01 0.406 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.926728e-01 0.406 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 4.470296e-01 0.350 0 0
Differentiation of T cells R-HSA-9945266 4.470296e-01 0.350 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.982688e-01 0.400 0 0
Signalling to RAS R-HSA-167044 3.982688e-01 0.400 0 0
Histamine receptors R-HSA-390650 4.599697e-01 0.337 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.650206e-01 0.577 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.820673e-01 0.418 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.148383e-01 0.382 0 0
Inositol phosphate metabolism R-HSA-1483249 3.624910e-01 0.441 0 0
Diseases of Base Excision Repair R-HSA-9605308 2.589627e-01 0.587 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.914059e-01 0.407 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.090273e-01 0.510 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.891407e-01 0.410 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.347152e-01 0.629 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.489570e-01 0.457 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.599697e-01 0.337 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 3.982688e-01 0.400 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.255878e-01 0.371 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 4.525804e-01 0.344 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.452036e-01 0.610 0 0
Influenza Infection R-HSA-168255 3.242834e-01 0.489 0 0
FasL/ CD95L signaling R-HSA-75157 4.599697e-01 0.337 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.926728e-01 0.406 0 0
Interleukin-1 processing R-HSA-448706 4.350072e-01 0.362 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.148383e-01 0.382 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.086337e-01 0.389 0 0
Gap junction assembly R-HSA-190861 3.930832e-01 0.406 0 0
SARS-CoV Infections R-HSA-9679506 2.484966e-01 0.605 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.155551e-01 0.501 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 4.470296e-01 0.350 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 2.452036e-01 0.610 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.596566e-01 0.338 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.873115e-01 0.542 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.493310e-01 0.603 0 0
IRE1alpha activates chaperones R-HSA-381070 3.658732e-01 0.437 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.155546e-01 0.501 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.421647e-01 0.616 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 2.650206e-01 0.577 0 0
Transcription of the HIV genome R-HSA-167172 4.605117e-01 0.337 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.606969e-01 0.337 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.607755e-01 0.337 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.607755e-01 0.337 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.697350e-01 0.328 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.707423e-01 0.327 0 0
Adherens junctions interactions R-HSA-418990 4.748685e-01 0.323 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.756930e-01 0.323 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.756930e-01 0.323 0 0
Pexophagy R-HSA-9664873 4.756930e-01 0.323 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.756930e-01 0.323 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.756930e-01 0.323 0 0
Josephin domain DUBs R-HSA-5689877 4.756930e-01 0.323 0 0
Signal attenuation R-HSA-74749 4.756930e-01 0.323 0 0
Interleukin-27 signaling R-HSA-9020956 4.756930e-01 0.323 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.756930e-01 0.323 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.756930e-01 0.323 1 1
Signaling by Leptin R-HSA-2586552 4.756930e-01 0.323 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 4.760255e-01 0.322 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.772179e-01 0.321 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.777912e-01 0.321 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.777912e-01 0.321 0 0
Somitogenesis R-HSA-9824272 4.783268e-01 0.320 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.784851e-01 0.320 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.784851e-01 0.320 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.784851e-01 0.320 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.784851e-01 0.320 0 0
Syndecan interactions R-HSA-3000170 4.791444e-01 0.320 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.888141e-01 0.311 0 0
COPII-mediated vesicle transport R-HSA-204005 4.926388e-01 0.307 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.941301e-01 0.306 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.968400e-01 0.304 0 0
Ub-specific processing proteases R-HSA-5689880 4.993552e-01 0.302 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.997153e-01 0.301 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.017662e-01 0.299 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.021816e-01 0.299 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.051901e-01 0.297 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.051901e-01 0.297 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 5.090752e-01 0.293 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.090752e-01 0.293 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.108925e-01 0.292 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.124610e-01 0.290 0 0
HDACs deacetylate histones R-HSA-3214815 5.135728e-01 0.289 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.145434e-01 0.289 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.145434e-01 0.289 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.145434e-01 0.289 0 0
Interleukin-2 signaling R-HSA-9020558 5.145434e-01 0.289 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.145434e-01 0.289 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 5.145434e-01 0.289 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.145434e-01 0.289 0 0
Prostanoid ligand receptors R-HSA-391908 5.145434e-01 0.289 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.145434e-01 0.289 0 0
Dissolution of Fibrin Clot R-HSA-75205 5.145434e-01 0.289 0 0
Deubiquitination R-HSA-5688426 5.152552e-01 0.288 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.165474e-01 0.287 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.181064e-01 0.286 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.188677e-01 0.285 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.203396e-01 0.284 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.203396e-01 0.284 0 0
Generation of second messenger molecules R-HSA-202433 5.203396e-01 0.284 0 0
Signaling by MET R-HSA-6806834 5.214239e-01 0.283 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 5.225897e-01 0.282 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.225897e-01 0.282 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.225897e-01 0.282 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.225897e-01 0.282 0 0
Nucleotide catabolism defects R-HSA-9735786 5.225897e-01 0.282 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.225897e-01 0.282 0 0
Signaling by LRP5 mutants R-HSA-5339717 5.225897e-01 0.282 0 0
Regulation of gap junction activity R-HSA-191650 5.225897e-01 0.282 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.225897e-01 0.282 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.225897e-01 0.282 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.225897e-01 0.282 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.225897e-01 0.282 0 0
Sensory perception of sour taste R-HSA-9729555 5.225897e-01 0.282 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.225897e-01 0.282 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.225897e-01 0.282 0 0
Transmission across Electrical Synapses R-HSA-112307 5.225897e-01 0.282 0 0
Nuclear RNA decay R-HSA-9930044 5.248408e-01 0.280 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.248408e-01 0.280 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.263364e-01 0.279 0 0
Adaptive Immune System R-HSA-1280218 5.294236e-01 0.276 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 5.306394e-01 0.275 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.306394e-01 0.275 0 0
HDMs demethylate histones R-HSA-3214842 5.306394e-01 0.275 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.311580e-01 0.275 0 0
Signaling by FGFR1 R-HSA-5654736 5.311580e-01 0.275 0 0
Signaling by WNT R-HSA-195721 5.334769e-01 0.273 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.386949e-01 0.269 0 0
PKA activation R-HSA-163615 5.386949e-01 0.269 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.386949e-01 0.269 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.386949e-01 0.269 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 5.386949e-01 0.269 0 0
Signaling by Hedgehog R-HSA-5358351 5.398184e-01 0.268 0 0
Ca2+ pathway R-HSA-4086398 5.398447e-01 0.268 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.406204e-01 0.267 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.470377e-01 0.262 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.470377e-01 0.262 0 0
Mitochondrial biogenesis R-HSA-1592230 5.475500e-01 0.262 0 0
Cell-cell junction organization R-HSA-421270 5.507323e-01 0.259 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.509984e-01 0.259 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.514370e-01 0.259 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.514370e-01 0.259 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.514370e-01 0.259 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.514370e-01 0.259 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 5.514370e-01 0.259 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.514370e-01 0.259 0 0
Signaling by FGFR in disease R-HSA-1226099 5.552324e-01 0.256 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.554258e-01 0.255 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.554258e-01 0.255 0 0
Generic Transcription Pathway R-HSA-212436 5.652897e-01 0.248 0 0
Regulation of signaling by CBL R-HSA-912631 5.672615e-01 0.246 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.672615e-01 0.246 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.672615e-01 0.246 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.672615e-01 0.246 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.672615e-01 0.246 0 0
Rap1 signalling R-HSA-392517 5.672615e-01 0.246 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 5.672615e-01 0.246 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.672615e-01 0.246 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.687257e-01 0.245 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.687257e-01 0.245 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.720172e-01 0.243 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.779517e-01 0.238 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.779517e-01 0.238 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.779517e-01 0.238 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.779517e-01 0.238 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.779517e-01 0.238 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.779517e-01 0.238 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.779517e-01 0.238 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.779517e-01 0.238 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.779517e-01 0.238 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.779517e-01 0.238 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.779517e-01 0.238 0 0
Co-inhibition by BTLA R-HSA-9927353 5.779517e-01 0.238 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.779517e-01 0.238 0 0
Nucleotide Excision Repair R-HSA-5696398 5.793608e-01 0.237 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.794932e-01 0.237 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 5.794932e-01 0.237 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.794932e-01 0.237 0 0
Neuronal System R-HSA-112316 5.828435e-01 0.234 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.863054e-01 0.232 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.863054e-01 0.232 0 0
Interleukin-15 signaling R-HSA-8983432 5.863054e-01 0.232 0 0
Interleukin-35 Signalling R-HSA-8984722 5.863054e-01 0.232 0 0
Repression of WNT target genes R-HSA-4641265 5.863054e-01 0.232 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.863054e-01 0.232 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.898649e-01 0.229 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.898649e-01 0.229 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.898649e-01 0.229 0 0
Transferrin endocytosis and recycling R-HSA-917977 5.898649e-01 0.229 0 0
Platelet homeostasis R-HSA-418346 5.919328e-01 0.228 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.947126e-01 0.226 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.947126e-01 0.226 0 0
FOXO-mediated transcription R-HSA-9614085 5.967385e-01 0.224 0 0
tRNA Aminoacylation R-HSA-379724 5.988406e-01 0.223 0 0
Protein folding R-HSA-391251 6.020395e-01 0.220 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.027962e-01 0.220 0 0
Telomere Extension By Telomerase R-HSA-171319 6.027962e-01 0.220 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.070049e-01 0.217 0 0
Orc1 removal from chromatin R-HSA-68949 6.073426e-01 0.217 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.094214e-01 0.215 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.104212e-01 0.214 0 0
RNA Polymerase III Transcription R-HSA-74158 6.104212e-01 0.214 0 0
Triglyceride catabolism R-HSA-163560 6.104212e-01 0.214 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.120550e-01 0.213 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.145617e-01 0.211 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.165776e-01 0.210 0 0
Netrin-1 signaling R-HSA-373752 6.175979e-01 0.209 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.175979e-01 0.209 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 6.191220e-01 0.208 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 6.191220e-01 0.208 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 6.191220e-01 0.208 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.191220e-01 0.208 0 0
Formation of axial mesoderm R-HSA-9796292 6.191220e-01 0.208 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 6.191220e-01 0.208 0 0
Diseases of nucleotide metabolism R-HSA-9735804 6.191220e-01 0.208 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.191220e-01 0.208 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.191220e-01 0.208 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 6.191220e-01 0.208 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.191220e-01 0.208 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.199643e-01 0.208 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.210035e-01 0.207 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.210035e-01 0.207 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.210035e-01 0.207 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.220942e-01 0.206 0 0
Amino acids regulate mTORC1 R-HSA-9639288 6.243693e-01 0.205 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.243693e-01 0.205 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.252985e-01 0.204 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.252985e-01 0.204 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.252985e-01 0.204 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.268966e-01 0.203 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.268966e-01 0.203 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.268966e-01 0.203 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.268966e-01 0.203 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.268966e-01 0.203 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.268966e-01 0.203 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.268966e-01 0.203 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 6.268966e-01 0.203 0 0
Signaling by MST1 R-HSA-8852405 6.268966e-01 0.203 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.268966e-01 0.203 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.268966e-01 0.203 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.268966e-01 0.203 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.268966e-01 0.203 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.268966e-01 0.203 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.268966e-01 0.203 0 0
PKB-mediated events R-HSA-109703 6.268966e-01 0.203 0 0
PDE3B signalling R-HSA-165160 6.268966e-01 0.203 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.268966e-01 0.203 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.268966e-01 0.203 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.268966e-01 0.203 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.287627e-01 0.202 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.303661e-01 0.200 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.307812e-01 0.200 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.323654e-01 0.199 0 0
RNA Polymerase II Transcription R-HSA-73857 6.334095e-01 0.198 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.340523e-01 0.198 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.345337e-01 0.198 0 0
Cardiac conduction R-HSA-5576891 6.355820e-01 0.197 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.356641e-01 0.197 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.356641e-01 0.197 0 0
Signaling by FGFR2 R-HSA-5654738 6.426853e-01 0.192 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.461058e-01 0.190 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.461058e-01 0.190 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.461058e-01 0.190 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.461058e-01 0.190 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.461058e-01 0.190 0 0
Ribavirin ADME R-HSA-9755088 6.461058e-01 0.190 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.462147e-01 0.190 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.469727e-01 0.189 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 6.469727e-01 0.189 0 0
Peptide chain elongation R-HSA-156902 6.482428e-01 0.188 0 0
Depurination R-HSA-73927 6.496769e-01 0.187 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.496769e-01 0.187 0 0
Prolactin receptor signaling R-HSA-1170546 6.498938e-01 0.187 0 0
Removal of the Flap Intermediate R-HSA-69166 6.498938e-01 0.187 0 0
Regulation of KIT signaling R-HSA-1433559 6.498938e-01 0.187 0 0
cGMP effects R-HSA-418457 6.498938e-01 0.187 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 6.498938e-01 0.187 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 6.498938e-01 0.187 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 6.498938e-01 0.187 0 0
Acyl chain remodeling of CL R-HSA-1482798 6.498938e-01 0.187 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.513339e-01 0.186 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.516319e-01 0.186 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.516319e-01 0.186 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.516319e-01 0.186 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.532158e-01 0.185 0 0
Signaling by TGFBR3 R-HSA-9839373 6.532158e-01 0.185 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.571526e-01 0.182 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.586966e-01 0.181 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.654607e-01 0.177 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 6.677996e-01 0.175 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.677996e-01 0.175 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.677996e-01 0.175 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.683359e-01 0.175 0 0
Stabilization of p53 R-HSA-69541 6.683359e-01 0.175 0 0
Pentose phosphate pathway R-HSA-71336 6.683359e-01 0.175 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.700048e-01 0.174 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.700048e-01 0.174 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.701679e-01 0.174 0 0
Signaling by LTK in cancer R-HSA-9842640 6.701679e-01 0.174 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.701679e-01 0.174 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.701679e-01 0.174 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.701679e-01 0.174 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.701679e-01 0.174 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 6.701679e-01 0.174 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.701679e-01 0.174 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.701679e-01 0.174 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.701679e-01 0.174 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.701679e-01 0.174 0 0
MET Receptor Activation R-HSA-6806942 6.701679e-01 0.174 0 0
Abacavir transmembrane transport R-HSA-2161517 6.701679e-01 0.174 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 6.701679e-01 0.174 0 0
CREB phosphorylation R-HSA-199920 6.701679e-01 0.174 0 0
Metabolism of vitamin K R-HSA-6806664 6.701679e-01 0.174 0 0
NADPH regeneration R-HSA-389542 6.701679e-01 0.174 0 0
VLDL assembly R-HSA-8866423 6.701679e-01 0.174 0 0
HDL clearance R-HSA-8964011 6.701679e-01 0.174 0 0
Neurofascin interactions R-HSA-447043 6.701679e-01 0.174 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.702378e-01 0.174 0 0
Cellular response to starvation R-HSA-9711097 6.714082e-01 0.173 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.728806e-01 0.172 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 6.728806e-01 0.172 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.728806e-01 0.172 0 0
Downstream TCR signaling R-HSA-202424 6.738144e-01 0.171 0 0
Co-inhibition by PD-1 R-HSA-389948 6.760312e-01 0.170 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.786536e-01 0.168 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.786536e-01 0.168 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.786536e-01 0.168 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.786536e-01 0.168 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.786536e-01 0.168 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.786536e-01 0.168 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.786536e-01 0.168 0 0
Protein lipoylation R-HSA-9857492 6.786536e-01 0.168 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.826819e-01 0.166 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.861860e-01 0.164 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.863300e-01 0.163 0 0
DNA strand elongation R-HSA-69190 6.877670e-01 0.163 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.877670e-01 0.163 0 0
Interleukin-20 family signaling R-HSA-8854691 6.926977e-01 0.159 0 0
Growth hormone receptor signaling R-HSA-982772 6.926977e-01 0.159 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.982727e-01 0.156 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.029566e-01 0.153 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 7.036508e-01 0.153 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.036508e-01 0.153 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.036508e-01 0.153 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.042834e-01 0.152 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 7.054542e-01 0.152 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 7.054542e-01 0.152 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.054542e-01 0.152 0 0
Killing mechanisms R-HSA-9664420 7.054542e-01 0.152 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.054542e-01 0.152 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.054542e-01 0.152 0 0
Regulation of BACH1 activity R-HSA-9708530 7.054542e-01 0.152 0 0
Negative regulation of FLT3 R-HSA-9706369 7.054542e-01 0.152 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.054542e-01 0.152 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.068694e-01 0.151 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.068694e-01 0.151 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.084230e-01 0.150 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.084230e-01 0.150 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.084230e-01 0.150 0 0
Recycling of eIF2:GDP R-HSA-72731 7.084230e-01 0.150 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 7.084230e-01 0.150 0 0
Disinhibition of SNARE formation R-HSA-114516 7.084230e-01 0.150 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.084230e-01 0.150 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.084230e-01 0.150 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.084230e-01 0.150 0 0
LDL remodeling R-HSA-8964041 7.084230e-01 0.150 0 0
Ca2+ activated K+ channels R-HSA-1296052 7.084230e-01 0.150 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.084230e-01 0.150 0 0
Netrin mediated repulsion signals R-HSA-418886 7.084230e-01 0.150 0 0
CHL1 interactions R-HSA-447041 7.084230e-01 0.150 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.084230e-01 0.150 0 0
HCMV Early Events R-HSA-9609690 7.134913e-01 0.147 0 0
Deadenylation of mRNA R-HSA-429947 7.141923e-01 0.146 0 0
Stimuli-sensing channels R-HSA-2672351 7.150781e-01 0.146 0 0
Ribosome-associated quality control R-HSA-9948299 7.165453e-01 0.145 0 0
Extension of Telomeres R-HSA-180786 7.172904e-01 0.144 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.175505e-01 0.144 0 0
PI3K Cascade R-HSA-109704 7.180218e-01 0.144 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.202938e-01 0.142 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.202938e-01 0.142 0 0
HIV Transcription Initiation R-HSA-167161 7.202938e-01 0.142 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.202938e-01 0.142 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.202938e-01 0.142 0 0
Adipogenesis R-HSA-9843745 7.231201e-01 0.141 0 0
Viral Infection Pathways R-HSA-9824446 7.249872e-01 0.140 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.251072e-01 0.140 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.251072e-01 0.140 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.256241e-01 0.139 0 0
Developmental Biology R-HSA-1266738 7.289140e-01 0.137 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.303631e-01 0.136 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.303631e-01 0.136 0 0
Glycine degradation R-HSA-6783984 7.303631e-01 0.136 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.303631e-01 0.136 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.303631e-01 0.136 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 7.303631e-01 0.136 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.311488e-01 0.136 0 0
RAB geranylgeranylation R-HSA-8873719 7.311488e-01 0.136 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.328362e-01 0.135 0 0
TGFBR3 expression R-HSA-9839394 7.345049e-01 0.134 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.345049e-01 0.134 0 0
Tight junction interactions R-HSA-420029 7.345049e-01 0.134 0 0
Formation of the nephric duct R-HSA-9830364 7.345049e-01 0.134 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.362583e-01 0.133 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.362583e-01 0.133 0 0
Depyrimidination R-HSA-73928 7.362583e-01 0.133 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.417673e-01 0.130 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.422431e-01 0.129 0 0
phospho-PLA2 pathway R-HSA-111995 7.422431e-01 0.129 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.422431e-01 0.129 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.422431e-01 0.129 0 0
Formation of annular gap junctions R-HSA-196025 7.422431e-01 0.129 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.422431e-01 0.129 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.422431e-01 0.129 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.422431e-01 0.129 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.422431e-01 0.129 0 0
Nucleotide salvage defects R-HSA-9734207 7.422431e-01 0.129 0 0
Alpha-defensins R-HSA-1462054 7.422431e-01 0.129 0 0
Modulation by Mtb of host immune system R-HSA-9637628 7.422431e-01 0.129 0 0
Interleukin-23 signaling R-HSA-9020933 7.422431e-01 0.129 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.424859e-01 0.129 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.424859e-01 0.129 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.424859e-01 0.129 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.424859e-01 0.129 0 0
Sensory processing of sound R-HSA-9659379 7.428100e-01 0.129 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.436814e-01 0.129 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.470906e-01 0.127 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.470906e-01 0.127 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.515467e-01 0.124 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.515467e-01 0.124 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.515467e-01 0.124 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.534585e-01 0.123 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.534585e-01 0.123 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.534585e-01 0.123 0 0
Specification of primordial germ cells R-HSA-9827857 7.534585e-01 0.123 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.536591e-01 0.123 0 0
TRP channels R-HSA-3295583 7.536591e-01 0.123 0 0
Metalloprotease DUBs R-HSA-5689901 7.536591e-01 0.123 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.536591e-01 0.123 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 7.536591e-01 0.123 0 0
Eukaryotic Translation Termination R-HSA-72764 7.542840e-01 0.122 0 0
Platelet degranulation R-HSA-114608 7.581505e-01 0.120 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.590156e-01 0.120 0 0
Regulation of Apoptosis R-HSA-169911 7.590156e-01 0.120 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.607867e-01 0.119 0 0
ER-Phagosome pathway R-HSA-1236974 7.648408e-01 0.116 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.661646e-01 0.116 0 0
Proteasome assembly R-HSA-9907900 7.661646e-01 0.116 0 0
DAP12 interactions R-HSA-2172127 7.661646e-01 0.116 0 0
Packaging Of Telomere Ends R-HSA-171306 7.716843e-01 0.113 0 0
Insulin processing R-HSA-264876 7.716843e-01 0.113 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.721422e-01 0.112 0 0
Gap junction degradation R-HSA-190873 7.721422e-01 0.112 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.721422e-01 0.112 0 0
WNT mediated activation of DVL R-HSA-201688 7.721422e-01 0.112 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.721422e-01 0.112 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.721422e-01 0.112 0 0
mRNA Editing R-HSA-75072 7.721422e-01 0.112 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.721422e-01 0.112 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.721422e-01 0.112 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.721422e-01 0.112 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.721422e-01 0.112 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.721422e-01 0.112 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.721422e-01 0.112 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.721422e-01 0.112 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.721422e-01 0.112 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.739283e-01 0.111 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.739283e-01 0.111 0 0
Telomere Maintenance R-HSA-157579 7.745800e-01 0.111 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.748259e-01 0.111 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.748259e-01 0.111 0 0
PKA activation in glucagon signalling R-HSA-164378 7.748259e-01 0.111 0 0
Nephron development R-HSA-9831926 7.748259e-01 0.111 0 0
Apoptotic factor-mediated response R-HSA-111471 7.748259e-01 0.111 0 0
Neurotransmitter release cycle R-HSA-112310 7.752536e-01 0.111 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.801203e-01 0.108 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.801203e-01 0.108 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.801203e-01 0.108 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.801203e-01 0.108 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.801203e-01 0.108 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.842317e-01 0.106 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.853340e-01 0.105 0 0
G alpha (z) signalling events R-HSA-418597 7.865212e-01 0.104 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.886150e-01 0.103 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.886150e-01 0.103 0 0
Pyroptosis R-HSA-5620971 7.886150e-01 0.103 0 0
Voltage gated Potassium channels R-HSA-1296072 7.895874e-01 0.103 0 0
Degradation of AXIN R-HSA-4641257 7.895874e-01 0.103 0 0
Degradation of DVL R-HSA-4641258 7.895874e-01 0.103 0 0
Cleavage of the damaged purine R-HSA-110331 7.895874e-01 0.103 0 0
Signaling by ERBB4 R-HSA-1236394 7.896026e-01 0.103 0 0
ROS and RNS production in phagocytes R-HSA-1222556 7.896026e-01 0.103 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.923152e-01 0.101 0 0
Synthesis of DNA R-HSA-69239 7.927792e-01 0.101 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.934244e-01 0.100 0 0
HATs acetylate histones R-HSA-3214847 7.936655e-01 0.100 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.945553e-01 0.100 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.945553e-01 0.100 0 0
Other interleukin signaling R-HSA-449836 7.945553e-01 0.100 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.945553e-01 0.100 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.985746e-01 0.098 0 0
OADH complex synthesizes glutaryl-CoA from 2-OA R-HSA-9858328 7.985746e-01 0.098 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.985746e-01 0.098 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.985746e-01 0.098 0 0
PI3K/AKT activation R-HSA-198203 7.985746e-01 0.098 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.985746e-01 0.098 0 0
DNA replication initiation R-HSA-68952 7.985746e-01 0.098 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.985746e-01 0.098 0 0
Maturation of spike protein R-HSA-9683686 7.985746e-01 0.098 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.985746e-01 0.098 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.985746e-01 0.098 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.985746e-01 0.098 0 0
Formation of apoptosome R-HSA-111458 7.985746e-01 0.098 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.044891e-01 0.094 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.060894e-01 0.094 0 0
Immune System R-HSA-168256 8.065085e-01 0.093 0 0
Innate Immune System R-HSA-168249 8.091473e-01 0.092 0 0
UCH proteinases R-HSA-5689603 8.103242e-01 0.091 0 0
Selenocysteine synthesis R-HSA-2408557 8.115520e-01 0.091 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.127392e-01 0.090 0 0
Negative regulation of MET activity R-HSA-6807004 8.127392e-01 0.090 0 0
Signaling by NODAL R-HSA-1181150 8.127392e-01 0.090 0 0
Creatine metabolism R-HSA-71288 8.127392e-01 0.090 0 0
Protein hydroxylation R-HSA-9629569 8.127392e-01 0.090 0 0
Signal transduction by L1 R-HSA-445144 8.127392e-01 0.090 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.127392e-01 0.090 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.127392e-01 0.090 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.153676e-01 0.089 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.169712e-01 0.088 0 0
Gluconeogenesis R-HSA-70263 8.181298e-01 0.087 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.193474e-01 0.087 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.193474e-01 0.087 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.200517e-01 0.086 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.219421e-01 0.085 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.219421e-01 0.085 0 0
LGI-ADAM interactions R-HSA-5682910 8.219421e-01 0.085 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.219421e-01 0.085 0 0
Conjugation of benzoate with glycine R-HSA-177135 8.219421e-01 0.085 0 0
Chylomicron assembly R-HSA-8963888 8.219421e-01 0.085 0 0
Synthesis of PI R-HSA-1483226 8.219421e-01 0.085 0 0
Transport of RCbl within the body R-HSA-9758890 8.219421e-01 0.085 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.219421e-01 0.085 0 0
PECAM1 interactions R-HSA-210990 8.219421e-01 0.085 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.241390e-01 0.084 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.254424e-01 0.083 0 0
PCP/CE pathway R-HSA-4086400 8.294528e-01 0.081 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.294705e-01 0.081 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 8.294705e-01 0.081 0 0
Lagging Strand Synthesis R-HSA-69186 8.294705e-01 0.081 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.294705e-01 0.081 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.294705e-01 0.081 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.294705e-01 0.081 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.294705e-01 0.081 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.295248e-01 0.081 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.295248e-01 0.081 0 0
Interleukin-2 family signaling R-HSA-451927 8.295248e-01 0.081 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.295248e-01 0.081 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.295613e-01 0.081 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.295613e-01 0.081 0 0
Triglyceride metabolism R-HSA-8979227 8.315742e-01 0.080 0 0
EGFR downregulation R-HSA-182971 8.332327e-01 0.079 0 0
Cargo concentration in the ER R-HSA-5694530 8.332327e-01 0.079 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.361805e-01 0.078 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.404011e-01 0.076 0 0
Maturation of spike protein R-HSA-9694548 8.413536e-01 0.075 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.413536e-01 0.075 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.414340e-01 0.075 0 0
Regulation of PTEN gene transcription R-HSA-8943724 8.415614e-01 0.075 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 8.415614e-01 0.075 0 0
DS-GAG biosynthesis R-HSA-2022923 8.425999e-01 0.074 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.425999e-01 0.074 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.425999e-01 0.074 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.425999e-01 0.074 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.425999e-01 0.074 0 0
FMO oxidises nucleophiles R-HSA-217271 8.425999e-01 0.074 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.425999e-01 0.074 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.425999e-01 0.074 0 0
Sodium/Calcium exchangers R-HSA-425561 8.425999e-01 0.074 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.425999e-01 0.074 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.425999e-01 0.074 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.448415e-01 0.073 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.461893e-01 0.073 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.461893e-01 0.073 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.510633e-01 0.070 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.524844e-01 0.069 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.524844e-01 0.069 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.524844e-01 0.069 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.524844e-01 0.069 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.525540e-01 0.069 0 0
Hedgehog 'on' state R-HSA-5632684 8.527700e-01 0.069 0 0
Cardiogenesis R-HSA-9733709 8.582618e-01 0.066 0 0
Base Excision Repair R-HSA-73884 8.582829e-01 0.066 0 0
FGFR2 alternative splicing R-HSA-6803529 8.589425e-01 0.066 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.589425e-01 0.066 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.589425e-01 0.066 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.600937e-01 0.065 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.603789e-01 0.065 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.603789e-01 0.065 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.608621e-01 0.065 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.608621e-01 0.065 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 8.608621e-01 0.065 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 8.608621e-01 0.065 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.608621e-01 0.065 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.608621e-01 0.065 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.608621e-01 0.065 0 0
Conjugation of salicylate with glycine R-HSA-177128 8.608621e-01 0.065 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.608621e-01 0.065 0 0
Leading Strand Synthesis R-HSA-69109 8.608621e-01 0.065 0 0
Polymerase switching R-HSA-69091 8.608621e-01 0.065 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.608621e-01 0.065 0 0
Signaling by LTK R-HSA-9842663 8.608621e-01 0.065 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.608621e-01 0.065 0 0
Signaling by FGFR R-HSA-190236 8.615904e-01 0.065 0 0
PTEN Regulation R-HSA-6807070 8.624649e-01 0.064 0 0
Activation of GABAB receptors R-HSA-991365 8.629451e-01 0.064 0 0
GABA B receptor activation R-HSA-977444 8.629451e-01 0.064 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.638812e-01 0.064 0 0
Leishmania infection R-HSA-9658195 8.639698e-01 0.064 0 0
Parasitic Infection Pathways R-HSA-9824443 8.639698e-01 0.064 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.686671e-01 0.061 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.694954e-01 0.061 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.694954e-01 0.061 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.694954e-01 0.061 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.706802e-01 0.060 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.718613e-01 0.060 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.718613e-01 0.060 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.718613e-01 0.060 0 0
Mitochondrial mRNA modification R-HSA-9937008 8.718613e-01 0.060 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.770064e-01 0.057 0 0
OGDH complex synthesizes succinyl-CoA from 2-OG R-HSA-9853506 8.770064e-01 0.057 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.770064e-01 0.057 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.770064e-01 0.057 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.770064e-01 0.057 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.770064e-01 0.057 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.770064e-01 0.057 0 0
Potential therapeutics for SARS R-HSA-9679191 8.777874e-01 0.057 0 0
Signaling by NOTCH2 R-HSA-1980145 8.799349e-01 0.056 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.799349e-01 0.056 0 0
Amine ligand-binding receptors R-HSA-375280 8.819690e-01 0.055 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.836823e-01 0.054 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.836823e-01 0.054 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.836823e-01 0.054 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.836823e-01 0.054 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.841142e-01 0.053 0 0
Iron uptake and transport R-HSA-917937 8.841142e-01 0.053 0 0
HCMV Infection R-HSA-9609646 8.843168e-01 0.053 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.859860e-01 0.053 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.896245e-01 0.051 0 0
PERK regulates gene expression R-HSA-381042 8.896245e-01 0.051 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.905893e-01 0.050 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.905893e-01 0.050 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.912444e-01 0.050 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.912783e-01 0.050 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.912783e-01 0.050 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.912783e-01 0.050 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.912783e-01 0.050 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.912783e-01 0.050 0 0
Hydrolysis of LPC R-HSA-1483115 8.912783e-01 0.050 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.912783e-01 0.050 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.912783e-01 0.050 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 8.912783e-01 0.050 0 0
Physiological factors R-HSA-5578768 8.912783e-01 0.050 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.912783e-01 0.050 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.912783e-01 0.050 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.912783e-01 0.050 0 0
P2Y receptors R-HSA-417957 8.912783e-01 0.050 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.912783e-01 0.050 0 0
Viral mRNA Translation R-HSA-192823 8.935745e-01 0.049 0 0
G protein gated Potassium channels R-HSA-1296059 8.944863e-01 0.048 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.944863e-01 0.048 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.944863e-01 0.048 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.944863e-01 0.048 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.944863e-01 0.048 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.986076e-01 0.046 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.986076e-01 0.046 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.017001e-01 0.045 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.024199e-01 0.045 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.038949e-01 0.044 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 9.038949e-01 0.044 0 0
Translesion synthesis by REV1 R-HSA-110312 9.038949e-01 0.044 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.038949e-01 0.044 0 0
Signaling by Activin R-HSA-1502540 9.038949e-01 0.044 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 9.038949e-01 0.044 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.038949e-01 0.044 0 0
Transport and metabolism of PAPS R-HSA-174362 9.038949e-01 0.044 0 0
Other semaphorin interactions R-HSA-416700 9.038949e-01 0.044 0 0
DNA Damage Reversal R-HSA-73942 9.038949e-01 0.044 0 0
MET activates PTK2 signaling R-HSA-8874081 9.043500e-01 0.044 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.043500e-01 0.044 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.043500e-01 0.044 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.043500e-01 0.044 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.043500e-01 0.044 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.061880e-01 0.043 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.069264e-01 0.042 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.118787e-01 0.040 0 0
GPER1 signaling R-HSA-9634597 9.132218e-01 0.039 0 0
Cristae formation R-HSA-8949613 9.133462e-01 0.039 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.133462e-01 0.039 0 0
Signaling by BMP R-HSA-201451 9.133462e-01 0.039 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.133462e-01 0.039 0 0
Peroxisomal protein import R-HSA-9033241 9.145041e-01 0.039 0 0
MET promotes cell motility R-HSA-8875878 9.146218e-01 0.039 0 0
Translesion synthesis by POLI R-HSA-5656121 9.150480e-01 0.039 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.150480e-01 0.039 0 0
Activation of SMO R-HSA-5635838 9.150480e-01 0.039 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.150480e-01 0.039 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.150480e-01 0.039 0 0
Mitochondrial Uncoupling R-HSA-166187 9.150480e-01 0.039 0 0
Attachment and Entry R-HSA-9678110 9.150480e-01 0.039 0 0
Atorvastatin ADME R-HSA-9754706 9.150480e-01 0.039 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.171621e-01 0.038 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.190335e-01 0.037 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.197814e-01 0.036 0 0
Amyloid fiber formation R-HSA-977225 9.205262e-01 0.036 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.215432e-01 0.035 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.217332e-01 0.035 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.217332e-01 0.035 0 0
Metabolism of cofactors R-HSA-8978934 9.226300e-01 0.035 0 0
Translesion synthesis by POLK R-HSA-5655862 9.249073e-01 0.034 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.249073e-01 0.034 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.249073e-01 0.034 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.249073e-01 0.034 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.249073e-01 0.034 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.249073e-01 0.034 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.249073e-01 0.034 0 0
Phase 2 - plateau phase R-HSA-5576893 9.249073e-01 0.034 0 0
Synthesis of PG R-HSA-1483148 9.249073e-01 0.034 0 0
Formation of xylulose-5-phosphate R-HSA-5661270 9.249073e-01 0.034 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.249073e-01 0.034 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.249073e-01 0.034 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.249073e-01 0.034 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.249073e-01 0.034 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.255162e-01 0.034 0 0
Azathioprine ADME R-HSA-9748787 9.258929e-01 0.033 0 0
Aquaporin-mediated transport R-HSA-445717 9.261190e-01 0.033 0 0
tRNA processing R-HSA-72306 9.273407e-01 0.033 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.277787e-01 0.033 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.282987e-01 0.032 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.282987e-01 0.032 0 0
Glucagon-type ligand receptors R-HSA-420092 9.290055e-01 0.032 0 0
DNA Replication R-HSA-69306 9.313697e-01 0.031 0 0
Mitochondrial protein import R-HSA-1268020 9.313829e-01 0.031 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.315817e-01 0.031 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.336230e-01 0.030 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.336230e-01 0.030 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.336230e-01 0.030 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.336230e-01 0.030 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.357930e-01 0.029 0 0
Neurotransmitter clearance R-HSA-112311 9.357930e-01 0.029 0 0
Integration of energy metabolism R-HSA-163685 9.363548e-01 0.029 0 0
Hemostasis R-HSA-109582 9.375244e-01 0.028 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.413275e-01 0.026 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.413275e-01 0.026 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.413275e-01 0.026 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.413275e-01 0.026 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.413275e-01 0.026 0 0
Protein ubiquitination R-HSA-8852135 9.414559e-01 0.026 0 0
SLC transporter disorders R-HSA-5619102 9.445240e-01 0.025 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.450734e-01 0.025 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.450734e-01 0.025 0 0
Cellular response to hypoxia R-HSA-1234174 9.452201e-01 0.024 0 0
RSV-host interactions R-HSA-9833110 9.469012e-01 0.024 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.481381e-01 0.023 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.481381e-01 0.023 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.481381e-01 0.023 0 0
Pyrimidine biosynthesis R-HSA-500753 9.481381e-01 0.023 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.481381e-01 0.023 0 0
Specification of the neural plate border R-HSA-9834899 9.481381e-01 0.023 0 0
Conjugation of carboxylic acids R-HSA-159424 9.481381e-01 0.023 0 0
Amino Acid conjugation R-HSA-156587 9.481381e-01 0.023 0 0
Diseases of hemostasis R-HSA-9671793 9.481381e-01 0.023 0 0
Transport of nucleotide sugars R-HSA-727802 9.481381e-01 0.023 0 0
Maturation of nucleoprotein R-HSA-9694631 9.481381e-01 0.023 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.481381e-01 0.023 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.486010e-01 0.023 0 0
Parasite infection R-HSA-9664407 9.486010e-01 0.023 0 0
Leishmania phagocytosis R-HSA-9664417 9.486010e-01 0.023 0 0
Interferon gamma signaling R-HSA-877300 9.492562e-01 0.023 0 0
Potassium Channels R-HSA-1296071 9.514432e-01 0.022 0 0
Formation of the cornified envelope R-HSA-6809371 9.516235e-01 0.022 0 0
Recycling of bile acids and salts R-HSA-159418 9.526485e-01 0.021 0 0
Kidney development R-HSA-9830369 9.529881e-01 0.021 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.541585e-01 0.020 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.541585e-01 0.020 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.541585e-01 0.020 0 0
Melanin biosynthesis R-HSA-5662702 9.541585e-01 0.020 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.541585e-01 0.020 0 0
Formation of definitive endoderm R-HSA-9823730 9.541585e-01 0.020 0 0
Glycogen synthesis R-HSA-3322077 9.541585e-01 0.020 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 9.564833e-01 0.019 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 9.572593e-01 0.019 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.572593e-01 0.019 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.572593e-01 0.019 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.572593e-01 0.019 0 0
Phospholipid metabolism R-HSA-1483257 9.578256e-01 0.019 0 0
G-protein activation R-HSA-202040 9.594803e-01 0.018 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.594803e-01 0.018 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.594803e-01 0.018 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.594803e-01 0.018 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.594803e-01 0.018 0 0
Basigin interactions R-HSA-210991 9.594803e-01 0.018 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.594803e-01 0.018 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.594803e-01 0.018 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.594803e-01 0.018 0 0
Selenoamino acid metabolism R-HSA-2408522 9.609266e-01 0.017 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.614381e-01 0.017 0 0
eNOS activation R-HSA-203615 9.614381e-01 0.017 0 0
Hyaluronan metabolism R-HSA-2142845 9.614381e-01 0.017 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.618015e-01 0.017 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.618015e-01 0.017 0 0
ABC-family proteins mediated transport R-HSA-382556 9.627358e-01 0.016 0 0
PPARA activates gene expression R-HSA-1989781 9.629616e-01 0.016 0 0
rRNA processing R-HSA-72312 9.638047e-01 0.016 0 0
CS-GAG biosynthesis R-HSA-2022870 9.641846e-01 0.016 0 0
Assembly Of The HIV Virion R-HSA-175474 9.641846e-01 0.016 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.641846e-01 0.016 0 0
Attachment and Entry R-HSA-9694614 9.641846e-01 0.016 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.646272e-01 0.016 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.652231e-01 0.015 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.668337e-01 0.015 0 0
HCMV Late Events R-HSA-9610379 9.668337e-01 0.015 0 0
Developmental Cell Lineages R-HSA-9734767 9.672087e-01 0.014 0 0
GABA receptor activation R-HSA-977443 9.675046e-01 0.014 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.680922e-01 0.014 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.683430e-01 0.014 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.683430e-01 0.014 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.683430e-01 0.014 0 0
LDL clearance R-HSA-8964038 9.683430e-01 0.014 0 0
Ethanol oxidation R-HSA-71384 9.683430e-01 0.014 0 0
G alpha (q) signalling events R-HSA-416476 9.686432e-01 0.014 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.710641e-01 0.013 0 0
Collagen formation R-HSA-1474290 9.715090e-01 0.013 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.717489e-01 0.012 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.717489e-01 0.012 0 0
Metabolism of folate and pterines R-HSA-196757 9.717489e-01 0.012 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.720187e-01 0.012 0 0
Carnitine shuttle R-HSA-200425 9.720187e-01 0.012 0 0
Formation of the ureteric bud R-HSA-9830674 9.720187e-01 0.012 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.734965e-01 0.012 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.734965e-01 0.012 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.738213e-01 0.012 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.745516e-01 0.011 0 0
Purine salvage R-HSA-74217 9.745516e-01 0.011 0 0
Complex III assembly R-HSA-9865881 9.752679e-01 0.011 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.752679e-01 0.011 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.752679e-01 0.011 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.752679e-01 0.011 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.752679e-01 0.011 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.753470e-01 0.011 0 0
Protein localization R-HSA-9609507 9.767784e-01 0.010 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.770846e-01 0.010 0 0
Pyruvate metabolism R-HSA-70268 9.776383e-01 0.010 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.781399e-01 0.010 0 0
Hyaluronan degradation R-HSA-2160916 9.781399e-01 0.010 0 0
Laminin interactions R-HSA-3000157 9.781399e-01 0.010 0 0
Translation of Structural Proteins R-HSA-9694635 9.787627e-01 0.009 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.793727e-01 0.009 0 0
Integrin cell surface interactions R-HSA-216083 9.804345e-01 0.009 0 0
ABC transporter disorders R-HSA-5619084 9.804345e-01 0.009 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.806786e-01 0.008 0 0
Urea cycle R-HSA-70635 9.806786e-01 0.008 0 0
Abacavir ADME R-HSA-2161522 9.806786e-01 0.008 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.814386e-01 0.008 0 0
Translation R-HSA-72766 9.827209e-01 0.008 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.829226e-01 0.007 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.829226e-01 0.007 0 0
Triglyceride biosynthesis R-HSA-75109 9.829226e-01 0.007 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.829226e-01 0.007 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.829226e-01 0.007 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.829226e-01 0.007 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.833030e-01 0.007 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.837887e-01 0.007 0 0
Gastrulation R-HSA-9758941 9.843695e-01 0.007 0 0
Prednisone ADME R-HSA-9757110 9.849061e-01 0.007 0 0
Neddylation R-HSA-8951664 9.857733e-01 0.006 0 0
Dectin-2 family R-HSA-5621480 9.864655e-01 0.006 0 0
Synthesis of PA R-HSA-1483166 9.864655e-01 0.006 0 0
DNA methylation R-HSA-5334118 9.866593e-01 0.006 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.870884e-01 0.006 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.875966e-01 0.005 0 0
Surfactant metabolism R-HSA-5683826 9.878683e-01 0.005 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.890999e-01 0.005 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.895659e-01 0.005 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.895787e-01 0.005 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.895787e-01 0.005 0 0
Metabolism of polyamines R-HSA-351202 9.898858e-01 0.004 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.898858e-01 0.004 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.902092e-01 0.004 0 0
DAG1 glycosylations R-HSA-8931838 9.907893e-01 0.004 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.907893e-01 0.004 0 0
G alpha (i) signalling events R-HSA-418594 9.911766e-01 0.004 0 0
Synthesis of PC R-HSA-1483191 9.912079e-01 0.004 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.918594e-01 0.004 0 0
Regulation of insulin secretion R-HSA-422356 9.920559e-01 0.003 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.921068e-01 0.003 0 0
CS/DS degradation R-HSA-2024101 9.928053e-01 0.003 0 0
Heme degradation R-HSA-189483 9.928053e-01 0.003 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.936412e-01 0.003 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.936412e-01 0.003 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.936412e-01 0.003 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.936412e-01 0.003 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.937608e-01 0.003 0 0
Complex IV assembly R-HSA-9864848 9.942971e-01 0.002 0 0
The phototransduction cascade R-HSA-2514856 9.942971e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.944025e-01 0.002 0 0
Extracellular matrix organization R-HSA-1474244 9.948519e-01 0.002 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.949335e-01 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.950009e-01 0.002 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.950332e-01 0.002 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.950332e-01 0.002 0 0
Nucleotide biosynthesis R-HSA-8956320 9.954135e-01 0.002 0 0
O-linked glycosylation of mucins R-HSA-913709 9.954155e-01 0.002 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.956104e-01 0.002 0 0
Ubiquinol biosynthesis R-HSA-2142789 9.956104e-01 0.002 0 0
Lysine catabolism R-HSA-71064 9.956104e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.956104e-01 0.002 0 0
Mitochondrial protein degradation R-HSA-9837999 9.958110e-01 0.002 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.958160e-01 0.002 0 0
Elastic fibre formation R-HSA-1566948 9.961206e-01 0.002 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.961206e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.964440e-01 0.002 0 0
Signaling by ALK R-HSA-201556 9.965715e-01 0.001 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.965715e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.966091e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.966994e-01 0.001 0 0
GPCR downstream signalling R-HSA-388396 9.969573e-01 0.001 0 0
Tryptophan catabolism R-HSA-71240 9.969700e-01 0.001 0 0
Glycogen metabolism R-HSA-8982491 9.969700e-01 0.001 0 0
Disease R-HSA-1643685 9.970675e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.971797e-01 0.001 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.973222e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.973222e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.976335e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9683701 9.976335e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.978743e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.979389e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.980969e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.980969e-01 0.001 0 0
Defective pyroptosis R-HSA-9710421 9.981518e-01 0.001 0 0
Defensins R-HSA-1461973 9.981518e-01 0.001 0 0
Methylation R-HSA-156581 9.983667e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.983667e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.984501e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.985227e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.985535e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.985566e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.985566e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.985595e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.986926e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.987282e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.987282e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.988469e-01 0.001 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.989240e-01 0.000 0 0
Metal ion SLC transporters R-HSA-425410 9.990038e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.991197e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.991509e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.993020e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.993126e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.995257e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.995548e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.995808e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.995808e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.996022e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.997166e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.997399e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.997444e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.997700e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.997983e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.998005e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998158e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.998206e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.998258e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998389e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.999050e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999050e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999129e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999176e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.999190e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999355e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999421e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999421e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999489e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999548e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999548e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999584e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999634e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999653e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.999757e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999757e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999785e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999818e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999920e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999928e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999928e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999931e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999972e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999975e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999977e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999982e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999986e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999988e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999988e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999989e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999992e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999992e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999994e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999995e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999997e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999997e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999997e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999997e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999997e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999998e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999998e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Macroautophagy R-HSA-1632852 0.000009 5.033 1 1
Autophagy R-HSA-9612973 0.000030 4.523 1 0
Regulation of TP53 Activity R-HSA-5633007 0.000048 4.323 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.000105 3.980 0 0
Cell Cycle R-HSA-1640170 0.000097 4.014 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.000132 3.880 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.000211 3.676 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.000229 3.640 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.000351 3.455 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.000418 3.379 0 0
MAP2K and MAPK activation R-HSA-5674135 0.000603 3.220 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.000603 3.220 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.000895 3.048 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.000902 3.045 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.001184 2.927 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.001184 2.927 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.001184 2.927 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.001184 2.927 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.001147 2.940 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.001457 2.836 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.001492 2.826 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.001492 2.826 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.001492 2.826 0 0
Signaling by RAS mutants R-HSA-6802949 0.001492 2.826 0 0
Adipogenesis R-HSA-9843745 0.001355 2.868 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.001619 2.791 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.001700 2.770 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.001938 2.713 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.002170 2.664 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.002424 2.616 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.002507 2.601 0 0
Chromatin organization R-HSA-4839726 0.002668 2.574 0 0
Chromatin modifying enzymes R-HSA-3247509 0.002797 2.553 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.002956 2.529 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.003445 2.463 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.003549 2.450 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.003549 2.450 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.003545 2.450 0 0
Deubiquitination R-HSA-5688426 0.003907 2.408 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.004234 2.373 0 0
Prolonged ERK activation events R-HSA-169893 0.004681 2.330 0 0
Cell Cycle, Mitotic R-HSA-69278 0.004831 2.316 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.005680 2.246 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.005660 2.247 0 0
Selective autophagy R-HSA-9663891 0.005557 2.255 1 0
Membrane Trafficking R-HSA-199991 0.005722 2.242 1 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 0.005885 2.230 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.006021 2.220 0 0
NRAGE signals death through JNK R-HSA-193648 0.006525 2.185 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.007152 2.146 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.007152 2.146 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.007301 2.137 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.007358 2.133 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.007947 2.100 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.007947 2.100 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.008084 2.092 0 0
Notch-HLH transcription pathway R-HSA-350054 0.008406 2.075 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 0.009283 2.032 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.009350 2.029 0 0
Homology Directed Repair R-HSA-5693538 0.009460 2.024 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.009839 2.007 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.010936 1.961 0 0
Death Receptor Signaling R-HSA-73887 0.010708 1.970 1 0
Regulation of PTEN gene transcription R-HSA-8943724 0.010648 1.973 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.010823 1.966 0 0
Mitotic Prometaphase R-HSA-68877 0.011068 1.956 0 0
Cell Cycle Checkpoints R-HSA-69620 0.011807 1.928 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.012988 1.886 0 0
Signaling by NOTCH1 R-HSA-1980143 0.013087 1.883 0 0
Neurofascin interactions R-HSA-447043 0.013755 1.862 0 0
G alpha (12/13) signalling events R-HSA-416482 0.015923 1.798 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.016940 1.771 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.016940 1.771 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.016305 1.788 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.019038 1.720 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.018189 1.740 0 0
Activation of RAC1 R-HSA-428540 0.019038 1.720 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.019578 1.708 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.019169 1.717 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.020080 1.697 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.020230 1.694 0 0
mRNA 3'-end processing R-HSA-72187 0.020877 1.680 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.021041 1.677 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.022459 1.649 0 0
Diseases of DNA repair R-HSA-9675135 0.023353 1.632 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.023522 1.629 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 0.023522 1.629 0 0
Pyroptosis R-HSA-5620971 0.023810 1.623 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.025434 1.595 0 0
Specification of primordial germ cells R-HSA-9827857 0.025586 1.592 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.026288 1.580 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.026288 1.580 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.026288 1.580 0 0
DNA Repair R-HSA-73894 0.026662 1.574 0 0
Heme signaling R-HSA-9707616 0.028071 1.552 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.030778 1.512 0 0
PPARA activates gene expression R-HSA-1989781 0.031725 1.499 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.031750 1.498 0 0
G2/M Transition R-HSA-69275 0.030323 1.518 0 0
Frs2-mediated activation R-HSA-170968 0.030329 1.518 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.029787 1.526 0 0
TNF signaling R-HSA-75893 0.031861 1.497 1 0
RUNX2 regulates bone development R-HSA-8941326 0.032746 1.485 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.033727 1.472 0 0
ARMS-mediated activation R-HSA-170984 0.034472 1.463 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.035598 1.449 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.036974 1.432 0 0
Manipulation of host energy metabolism R-HSA-9636667 0.037407 1.427 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.038725 1.412 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.038725 1.412 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.042455 1.372 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.040626 1.391 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.041181 1.385 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.042712 1.369 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.043114 1.365 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.046517 1.332 0 0
Centrosome maturation R-HSA-380287 0.045656 1.341 0 0
M Phase R-HSA-68886 0.045542 1.342 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.046474 1.333 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.046474 1.333 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.046474 1.333 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.046474 1.333 0 0
Mitochondrial biogenesis R-HSA-1592230 0.047511 1.323 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.046474 1.333 0 0
Regulated Necrosis R-HSA-5218859 0.048200 1.317 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.048219 1.317 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 0.048219 1.317 0 0
Apoptotic execution phase R-HSA-75153 0.050389 1.298 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.051850 1.285 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.062313 1.205 0 0
Regulation of TP53 Expression R-HSA-6804754 0.062313 1.205 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.062313 1.205 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 0.062313 1.205 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.062313 1.205 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.062313 1.205 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.062313 1.205 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.062313 1.205 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.062313 1.205 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.062313 1.205 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.062313 1.205 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.062313 1.205 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.062313 1.205 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.053861 1.269 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.052382 1.281 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.060079 1.221 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.057611 1.239 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.062028 1.207 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.059001 1.229 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.060452 1.219 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.052382 1.281 0 0
Mitophagy R-HSA-5205647 0.059001 1.229 1 0
G2/M Checkpoints R-HSA-69481 0.056336 1.249 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.058269 1.235 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.055281 1.257 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 0.095823 1.019 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 0.095823 1.019 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 0.095823 1.019 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 0.095823 1.019 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 0.095823 1.019 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.182468 0.739 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.182468 0.739 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.182468 0.739 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.182468 0.739 0 0
TICAM1 deficiency - HSE R-HSA-5602566 0.182468 0.739 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 0.182468 0.739 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 0.182468 0.739 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 0.182468 0.739 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.182468 0.739 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 0.182468 0.739 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.091284 1.040 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 0.063887 1.195 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 0.123315 0.909 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 0.123315 0.909 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 0.123315 0.909 0 0
Signaling by MAP2K mutants R-HSA-9652169 0.123315 0.909 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 0.260816 0.584 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 0.260816 0.584 0 0
t(4;14) translocations of FGFR3 R-HSA-2033515 0.260816 0.584 0 0
Signaling by FGFR3 fusions in cancer R-HSA-8853334 0.260816 0.584 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 0.260816 0.584 0 0
TRAF3 deficiency - HSE R-HSA-5602571 0.260816 0.584 0 0
Defective SLC9A9 causes autism 16 (AUTS16) R-HSA-5619052 0.260816 0.584 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 0.260816 0.584 0 0
XAV939 stabilizes AXIN R-HSA-5545619 0.260816 0.584 0 0
Defective CD320 causes MMATC R-HSA-3359485 0.260816 0.584 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 0.260816 0.584 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 0.260816 0.584 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 0.260816 0.584 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 0.260816 0.584 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 0.260816 0.584 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.081586 1.088 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 0.157552 0.803 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 0.157552 0.803 0 0
NrCAM interactions R-HSA-447038 0.157552 0.803 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 0.157552 0.803 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 0.157552 0.803 0 0
Type I hemidesmosome assembly R-HSA-446107 0.101137 0.995 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.101137 0.995 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.101137 0.995 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.066930 1.174 0 0
Lipophagy R-HSA-9613354 0.122345 0.912 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.122345 0.912 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 0.193281 0.714 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 0.193281 0.714 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 0.331659 0.479 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 0.331659 0.479 0 0
Potassium transport channels R-HSA-1296067 0.331659 0.479 0 0
Glycogen storage disease type II (GAA) R-HSA-5357609 0.331659 0.479 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 0.331659 0.479 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 0.331659 0.479 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 0.094943 1.023 0 0
Formation of axial mesoderm R-HSA-9796292 0.094943 1.023 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 0.145004 0.839 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.074103 1.130 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 0.229902 0.638 0 0
Signaling by APC mutants R-HSA-4839744 0.168904 0.772 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.168904 0.772 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.168904 0.772 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.168904 0.772 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 0.127557 0.894 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.127557 0.894 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 0.145397 0.837 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.193836 0.713 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.193836 0.713 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.193836 0.713 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.193836 0.713 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.266915 0.574 0 0
TRIF-mediated programmed cell death R-HSA-2562578 0.266915 0.574 0 0
PTK6 Expression R-HSA-8849473 0.266915 0.574 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 0.266915 0.574 0 0
SOS-mediated signalling R-HSA-112412 0.266915 0.574 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.266915 0.574 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 0.395716 0.403 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 0.395716 0.403 0 0
Axonal growth stimulation R-HSA-209563 0.395716 0.403 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 0.395716 0.403 0 0
Invadopodia formation R-HSA-8941237 0.395716 0.403 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 0.395716 0.403 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 0.395716 0.403 0 0
MET activates PTPN11 R-HSA-8865999 0.395716 0.403 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.075230 1.124 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.125102 0.903 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.219600 0.658 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.219600 0.658 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.219600 0.658 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.219600 0.658 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.219600 0.658 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.119816 0.921 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 0.303910 0.517 0 0
MET receptor recycling R-HSA-8875656 0.303910 0.517 0 0
Formation of annular gap junctions R-HSA-196025 0.303910 0.517 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.132384 0.878 0 0
FGFR3 mutant receptor activation R-HSA-2033514 0.246001 0.609 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 0.246001 0.609 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.246001 0.609 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.113465 0.945 0 0
Ephrin signaling R-HSA-3928664 0.203959 0.690 0 0
Late endosomal microautophagy R-HSA-9615710 0.145551 0.837 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.159287 0.798 0 0
Regulated proteolysis of p75NTR R-HSA-193692 0.340550 0.468 0 0
Gap junction degradation R-HSA-190873 0.340550 0.468 0 0
WNT mediated activation of DVL R-HSA-201688 0.340550 0.468 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 0.340550 0.468 0 0
ALK mutants bind TKIs R-HSA-9700645 0.340550 0.468 0 0
NADE modulates death signalling R-HSA-205025 0.453637 0.343 0 0
HCN channels R-HSA-1296061 0.453637 0.343 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.453637 0.343 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.453637 0.343 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 0.453637 0.343 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.076097 1.119 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.173559 0.761 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.173559 0.761 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.246233 0.609 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.299994 0.523 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.203572 0.691 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.203572 0.691 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.203572 0.691 0 0
Receptor Mediated Mitophagy R-HSA-8934903 0.376564 0.424 1 1
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.376564 0.424 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.241663 0.617 0 0
Striated Muscle Contraction R-HSA-390522 0.219238 0.659 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.219238 0.659 0 0
Phosphorylation of the APC/C R-HSA-176412 0.327259 0.485 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.327259 0.485 0 0
Metabolism of non-coding RNA R-HSA-194441 0.144519 0.840 0 0
snRNP Assembly R-HSA-191859 0.144519 0.840 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.290185 0.537 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.290185 0.537 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.154126 0.812 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.118721 0.925 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.251690 0.599 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 0.312557 0.505 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.354507 0.450 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 0.411735 0.385 0 0
IRS activation R-HSA-74713 0.506010 0.296 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.506010 0.296 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 0.506010 0.296 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.184770 0.733 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.184770 0.733 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.160283 0.795 1 1
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.202847 0.693 0 0
Deadenylation of mRNA R-HSA-429947 0.357656 0.447 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 0.445895 0.351 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 0.445895 0.351 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 0.445895 0.351 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.288630 0.540 0 0
Nucleosome assembly R-HSA-774815 0.288630 0.540 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 0.337487 0.472 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.275888 0.559 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.065889 1.181 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.408448 0.389 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 0.408448 0.389 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.402702 0.395 0 0
Regulation of signaling by CBL R-HSA-912631 0.434922 0.362 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 0.434922 0.362 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 0.434922 0.362 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.434922 0.362 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 0.478914 0.320 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.478914 0.320 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.478914 0.320 0 0
PDE3B signalling R-HSA-165160 0.553365 0.257 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 0.553365 0.257 0 0
PKB-mediated events R-HSA-109703 0.553365 0.257 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.553365 0.257 0 0
Signaling by RNF43 mutants R-HSA-5340588 0.553365 0.257 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.553365 0.257 0 0
Signaling by MAPK mutants R-HSA-9652817 0.553365 0.257 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 0.553365 0.257 0 0
Cristae formation R-HSA-8949613 0.425026 0.372 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.460941 0.336 0 0
PERK regulates gene expression R-HSA-381042 0.416160 0.381 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 0.510697 0.292 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.510697 0.292 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.400712 0.397 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.435679 0.361 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 0.486427 0.313 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.416909 0.380 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.468968 0.329 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.468968 0.329 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.429670 0.367 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.511316 0.291 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.511316 0.291 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 0.541178 0.267 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 0.541178 0.267 0 0
Signaling by LTK in cancer R-HSA-9842640 0.596183 0.225 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 0.596183 0.225 0 0
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) R-HSA-3656244 0.596183 0.225 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.596183 0.225 0 0
Defective CHST6 causes MCDC1 R-HSA-3656225 0.596183 0.225 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 0.596183 0.225 0 0
Defective ST3GAL3 causes MCT12 and EIEE15 R-HSA-3656243 0.596183 0.225 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 0.596183 0.225 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.397222 0.401 0 0
FGFR2 alternative splicing R-HSA-6803529 0.535551 0.271 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.532346 0.274 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 0.570314 0.244 0 0
Erythropoietin activates RAS R-HSA-9027284 0.570314 0.244 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 0.570314 0.244 0 0
Translesion synthesis by REV1 R-HSA-110312 0.570314 0.244 0 0
G beta:gamma signalling through BTK R-HSA-8964315 0.570314 0.244 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 0.570314 0.244 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.559087 0.253 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.559087 0.253 0 0
mRNA Splicing R-HSA-72172 0.491527 0.308 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.552629 0.258 0 0
Translesion synthesis by POLI R-HSA-5656121 0.598082 0.223 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.634898 0.197 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 0.634898 0.197 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 0.634898 0.197 0 0
IFNG signaling activates MAPKs R-HSA-9732724 0.634898 0.197 0 0
FGFR3b ligand binding and activation R-HSA-190371 0.634898 0.197 0 0
Recycling of eIF2:GDP R-HSA-72731 0.634898 0.197 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 0.634898 0.197 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 0.634898 0.197 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 0.634898 0.197 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 0.634898 0.197 0 0
Meiotic synapsis R-HSA-1221632 0.577554 0.238 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.580379 0.236 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.603925 0.219 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 0.603925 0.219 0 0
G protein gated Potassium channels R-HSA-1296059 0.603925 0.219 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 0.603925 0.219 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.596571 0.224 0 0
Translesion synthesis by POLK R-HSA-5655862 0.624479 0.204 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 0.624479 0.204 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 0.624479 0.204 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.623558 0.205 0 0
DNA Double Strand Break Response R-HSA-5693606 0.081988 1.086 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.097682 1.010 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.147686 0.831 0 0
Cellular response to heat stress R-HSA-3371556 0.492688 0.307 0 0
G0 and Early G1 R-HSA-1538133 0.188333 0.725 0 0
Integrin signaling R-HSA-354192 0.103089 0.987 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.268047 0.572 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.268047 0.572 0 0
EGFR downregulation R-HSA-182971 0.511617 0.291 0 0
EPH-Ephrin signaling R-HSA-2682334 0.234561 0.630 0 0
Nucleotide Excision Repair R-HSA-5696398 0.208175 0.682 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.183694 0.736 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.183694 0.736 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.548389 0.261 0 0
Aggrephagy R-HSA-9646399 0.199812 0.699 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.408448 0.389 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.402702 0.395 0 0
Formation of definitive endoderm R-HSA-9823730 0.111106 0.954 0 0
p75NTR signals via NF-kB R-HSA-193639 0.299994 0.523 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.159032 0.799 0 0
Pexophagy R-HSA-9664873 0.376564 0.424 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.340346 0.468 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.340346 0.468 0 0
Chromosome Maintenance R-HSA-73886 0.386869 0.412 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.527155 0.278 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.511316 0.291 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.340346 0.468 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.246001 0.609 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.223111 0.651 0 0
Cellular response to starvation R-HSA-9711097 0.506085 0.296 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 0.193836 0.713 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.107871 0.967 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.299675 0.523 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.486427 0.313 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 0.634898 0.197 0 0
TGFBR3 expression R-HSA-9839394 0.603925 0.219 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 0.354507 0.450 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 0.445895 0.351 0 0
G-protein beta:gamma signalling R-HSA-397795 0.552629 0.258 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.617130 0.210 0 0
Repression of WNT target genes R-HSA-4641265 0.080328 1.095 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.272855 0.564 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.474232 0.324 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.535551 0.271 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.577554 0.238 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.288630 0.540 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.205580 0.687 0 0
Interferon alpha/beta signaling R-HSA-909733 0.536645 0.270 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 0.624479 0.204 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.182758 0.738 1 1
RIPK1-mediated regulated necrosis R-HSA-5213460 0.474232 0.324 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.596571 0.224 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.129547 0.888 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.273158 0.564 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.434922 0.362 0 0
Signaling by FGFR3 R-HSA-5654741 0.443315 0.353 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.132384 0.878 0 0
Formation of lateral plate mesoderm R-HSA-9758920 0.193281 0.714 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 0.127557 0.894 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.111106 0.954 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.147473 0.831 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.555488 0.255 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.312557 0.505 0 0
RNA Polymerase I Transcription R-HSA-73864 0.164965 0.783 0 0
Signaling by EGFR R-HSA-177929 0.319275 0.496 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.110711 0.956 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.552629 0.258 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.558178 0.253 0 0
Rab regulation of trafficking R-HSA-9007101 0.077038 1.113 1 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 0.145397 0.837 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.117645 0.929 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.357148 0.447 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.123315 0.909 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.193836 0.713 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.219600 0.658 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 0.303910 0.517 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.171494 0.766 0 0
Regulation of gap junction activity R-HSA-191650 0.453637 0.343 0 0
Negative regulation of MET activity R-HSA-6807004 0.246233 0.609 0 0
Signaling by WNT in cancer R-HSA-4791275 0.188333 0.725 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.087492 1.058 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.167636 0.776 0 0
RAF activation R-HSA-5673000 0.235291 0.628 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.354507 0.450 0 0
NF-kB is activated and signals survival R-HSA-209560 0.445895 0.351 0 0
Meiosis R-HSA-1500620 0.233543 0.632 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.434922 0.362 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.425026 0.372 0 0
Separation of Sister Chromatids R-HSA-2467813 0.223120 0.651 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.328753 0.483 0 0
Regulation of CDH1 Function R-HSA-9764561 0.481074 0.318 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 0.535551 0.271 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.399241 0.399 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.455663 0.341 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.334026 0.476 0 0
RNA Polymerase II Transcription R-HSA-73857 0.347667 0.459 0 0
Oncogene Induced Senescence R-HSA-2559585 0.065805 1.182 0 0
Polo-like kinase mediated events R-HSA-156711 0.085574 1.068 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.203959 0.690 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.490477 0.309 0 0
Gene expression (Transcription) R-HSA-74160 0.113691 0.944 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.502152 0.299 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.502152 0.299 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.219600 0.658 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.116389 0.934 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.246233 0.609 0 0
Signal attenuation R-HSA-74749 0.376564 0.424 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.241663 0.617 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 0.381609 0.418 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.372724 0.429 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.443728 0.353 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.598082 0.223 0 0
MET activates RAS signaling R-HSA-8851805 0.478914 0.320 0 0
Insulin receptor signalling cascade R-HSA-74751 0.587570 0.231 0 0
Calcineurin activates NFAT R-HSA-2025928 0.122345 0.912 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 0.145004 0.839 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.110711 0.956 0 0
Metalloprotease DUBs R-HSA-5689901 0.107871 0.967 0 0
Josephin domain DUBs R-HSA-5689877 0.376564 0.424 0 0
Formation of the posterior neural plate R-HSA-9832991 0.411735 0.385 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 0.506010 0.296 0 0
PTK6 Down-Regulation R-HSA-8849472 0.506010 0.296 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 0.506010 0.296 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 0.445895 0.351 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.478914 0.320 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 0.553365 0.257 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.242545 0.615 0 0
Defective pyroptosis R-HSA-9710421 0.408111 0.389 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.393840 0.405 0 0
IRS-mediated signalling R-HSA-112399 0.481074 0.318 0 0
FGFR3 ligand binding and activation R-HSA-190239 0.570314 0.244 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 0.572435 0.242 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.598082 0.223 0 0
Killing mechanisms R-HSA-9664420 0.598082 0.223 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 0.634898 0.197 0 0
Glycine degradation R-HSA-6783984 0.624479 0.204 0 0
MTOR signalling R-HSA-165159 0.136870 0.864 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.205580 0.687 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.205580 0.687 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.468968 0.329 0 0
Kinesins R-HSA-983189 0.087734 1.057 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.063527 1.197 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 0.380222 0.420 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.510697 0.292 0 0
PTEN Regulation R-HSA-6807070 0.313576 0.504 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.570314 0.244 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.581888 0.235 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.402702 0.395 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.396534 0.402 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.136523 0.865 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.548389 0.261 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.110711 0.956 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 0.229902 0.638 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.127557 0.894 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.246001 0.609 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 0.272855 0.564 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 0.453637 0.343 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 0.453637 0.343 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 0.453637 0.343 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.299994 0.523 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.069703 1.157 0 0
HATs acetylate histones R-HSA-3214847 0.096192 1.017 0 0
Cilium Assembly R-HSA-5617833 0.220000 0.658 0 0
Meiotic recombination R-HSA-912446 0.384504 0.415 0 0
HDACs deacetylate histones R-HSA-3214815 0.449165 0.348 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.512452 0.290 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.552629 0.258 0 0
Signaling by NOTCH3 R-HSA-9012852 0.190067 0.721 0 0
Ca2+ pathway R-HSA-4086398 0.429670 0.367 0 0
RMTs methylate histone arginines R-HSA-3214858 0.600527 0.221 0 0
Signaling by MET R-HSA-6806834 0.183443 0.736 0 0
IGF1R signaling cascade R-HSA-2428924 0.438909 0.358 0 0
Signaling by NODAL R-HSA-1181150 0.460941 0.336 0 0
Cargo concentration in the ER R-HSA-5694530 0.511617 0.291 0 0
Signaling by FGFR in disease R-HSA-1226099 0.210219 0.677 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.089693 1.047 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.229902 0.638 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.229902 0.638 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.106809 0.971 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.106809 0.971 0 0
Rap1 signalling R-HSA-392517 0.434922 0.362 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 0.390423 0.408 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.447133 0.350 0 0
Inwardly rectifying K+ channels R-HSA-1296065 0.532346 0.274 0 0
Signaling by Hippo R-HSA-2028269 0.074103 1.130 0 0
Vesicle-mediated transport R-HSA-5653656 0.213941 0.670 1 0
Mitotic Anaphase R-HSA-68882 0.086224 1.064 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 0.598082 0.223 0 0
UCH proteinases R-HSA-5689603 0.341788 0.466 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.225956 0.646 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.380222 0.420 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.511316 0.291 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.438182 0.358 0 0
Signaling by TGFB family members R-HSA-9006936 0.342302 0.466 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 0.617130 0.210 0 0
Signalling to ERKs R-HSA-187687 0.065805 1.182 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.228228 0.642 0 0
Mitotic Prophase R-HSA-68875 0.481692 0.317 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.453857 0.343 0 0
Ub-specific processing proteases R-HSA-5689880 0.300736 0.522 0 0
Cellular Senescence R-HSA-2559583 0.157884 0.802 0 0
Gastrulation R-HSA-9758941 0.181249 0.742 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.603659 0.219 0 0
HIV Life Cycle R-HSA-162587 0.592155 0.228 0 0
Semaphorin interactions R-HSA-373755 0.423910 0.373 0 0
ESR-mediated signaling R-HSA-8939211 0.294215 0.531 0 0
SDK interactions R-HSA-373756 0.182468 0.739 0 0
MTF1 activates gene expression R-HSA-5660489 0.123315 0.909 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 0.260816 0.584 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 0.157552 0.803 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.193281 0.714 0 0
Proton/oligopeptide cotransporters R-HSA-427975 0.193281 0.714 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 0.193281 0.714 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 0.331659 0.479 0 0
Negative regulation of FLT3 R-HSA-9706369 0.145397 0.837 0 0
Signaling by AXIN mutants R-HSA-4839735 0.193836 0.713 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.266915 0.574 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 0.395716 0.403 0 0
MET interacts with TNS proteins R-HSA-8875513 0.395716 0.403 0 0
Signaling by LTK R-HSA-9842663 0.219600 0.658 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 0.303910 0.517 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.246001 0.609 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.246001 0.609 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.106809 0.971 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.272855 0.564 0 0
cGMP effects R-HSA-418457 0.272855 0.564 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.340550 0.468 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.376564 0.424 0 0
Suppression of autophagy R-HSA-9636569 0.506010 0.296 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.285362 0.545 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.285362 0.545 0 0
MET promotes cell motility R-HSA-8875878 0.302553 0.519 0 0
ERKs are inactivated R-HSA-202670 0.445895 0.351 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.408448 0.389 0 0
Presynaptic function of Kainate receptors R-HSA-500657 0.408448 0.389 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.265421 0.576 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.277641 0.557 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.478914 0.320 0 0
Regulation of IFNG signaling R-HSA-877312 0.478914 0.320 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 0.553365 0.257 0 0
Ceramide signalling R-HSA-193681 0.553365 0.257 0 0
Phosphorylation of Emi1 R-HSA-176417 0.553365 0.257 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.393840 0.405 0 0
Circadian clock R-HSA-9909396 0.326542 0.486 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.443315 0.353 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 0.596183 0.225 0 0
G2/M DNA replication checkpoint R-HSA-69478 0.596183 0.225 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.457133 0.340 0 0
PI3K Cascade R-HSA-109704 0.528893 0.277 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 0.598082 0.223 0 0
Opsins R-HSA-419771 0.634898 0.197 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.624479 0.204 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.399372 0.399 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.206935 0.684 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.457133 0.340 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.169356 0.771 0 0
Signaling by NOTCH R-HSA-157118 0.619453 0.208 0 0
Cellular responses to stress R-HSA-2262752 0.420503 0.376 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.408448 0.389 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.434922 0.362 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.478076 0.321 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.625179 0.204 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.199710 0.700 0 0
Biotin transport and metabolism R-HSA-196780 0.570314 0.244 0 0
Signal Transduction R-HSA-162582 0.197624 0.704 1 0
Spry regulation of FGF signaling R-HSA-1295596 0.570314 0.244 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.581888 0.235 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.401491 0.396 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 0.634898 0.197 0 0
PI Metabolism R-HSA-1483255 0.070478 1.152 0 0
Cellular responses to stimuli R-HSA-8953897 0.454470 0.342 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.150925 0.821 0 0
tRNA processing in the nucleus R-HSA-6784531 0.174262 0.759 0 0
TBC/RABGAPs R-HSA-8854214 0.257914 0.589 1 1
Long-term potentiation R-HSA-9620244 0.380222 0.420 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.552629 0.258 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.229286 0.640 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.229286 0.640 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.317248 0.499 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.199564 0.700 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.587570 0.231 0 0
Reproduction R-HSA-1474165 0.225894 0.646 0 0
Cell junction organization R-HSA-446728 0.315319 0.501 0 0
Diseases of programmed cell death R-HSA-9645723 0.513343 0.290 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.081586 1.088 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 0.193836 0.713 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.266915 0.574 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 0.340550 0.468 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 0.453637 0.343 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.219238 0.659 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.320129 0.495 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.402702 0.395 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.553365 0.257 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.535551 0.271 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.634898 0.197 0 0
Cell-cell junction organization R-HSA-421270 0.396824 0.401 0 0
Adherens junctions interactions R-HSA-418990 0.293148 0.533 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.103089 0.987 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.145551 0.837 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.312557 0.505 0 0
Cellular response to chemical stress R-HSA-9711123 0.600523 0.221 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.583525 0.234 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.213715 0.670 0 0
Sensory processing of sound R-HSA-9659379 0.265945 0.575 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.355049 0.450 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.511617 0.291 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.541407 0.266 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.071531 1.146 0 0
mTORC1-mediated signalling R-HSA-166208 0.312557 0.505 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.572993 0.242 0 0
Smooth Muscle Contraction R-HSA-445355 0.577554 0.238 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.603925 0.219 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.558178 0.253 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.083963 1.076 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.203959 0.690 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.598082 0.223 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.624479 0.204 0 0
Programmed Cell Death R-HSA-5357801 0.153066 0.815 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.160065 0.796 0 0
Cell-Cell communication R-HSA-1500931 0.581991 0.235 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.125102 0.903 0 0
HDMs demethylate histones R-HSA-3214842 0.205580 0.687 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.443315 0.353 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.203572 0.691 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.572993 0.242 0 0
Signaling by PTK6 R-HSA-8848021 0.572993 0.242 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 0.157552 0.803 0 0
Ca2+ activated K+ channels R-HSA-1296052 0.266915 0.574 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 0.266915 0.574 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.219600 0.658 0 0
TNFR1-mediated ceramide production R-HSA-5626978 0.453637 0.343 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 0.453637 0.343 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.186153 0.730 0 0
Transport of RCbl within the body R-HSA-9758890 0.411735 0.385 0 0
Inositol transporters R-HSA-429593 0.506010 0.296 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 0.506010 0.296 0 0
RSV-host interactions R-HSA-9833110 0.132847 0.877 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.357148 0.447 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 0.553365 0.257 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 0.486427 0.313 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.486427 0.313 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.541178 0.267 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 0.596183 0.225 0 0
Abacavir transmembrane transport R-HSA-2161517 0.596183 0.225 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 0.634898 0.197 0 0
Disorders of Developmental Biology R-HSA-9675151 0.624479 0.204 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.624479 0.204 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.624479 0.204 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.622314 0.206 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.467402 0.330 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.511887 0.291 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.201906 0.695 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.608289 0.216 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.445489 0.351 0 0
Post NMDA receptor activation events R-HSA-438064 0.500391 0.301 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.416160 0.381 0 0
Glycolysis R-HSA-70171 0.330909 0.480 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.340550 0.468 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 0.553365 0.257 0 0
Carnitine shuttle R-HSA-200425 0.559087 0.253 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.194935 0.710 0 0
Nuclear import of Rev protein R-HSA-180746 0.235291 0.628 0 0
Suppression of apoptosis R-HSA-9635465 0.411735 0.385 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 0.506010 0.296 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.378812 0.422 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.552629 0.258 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.115297 0.938 0 0
FLT3 Signaling R-HSA-9607240 0.355049 0.450 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.615517 0.211 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.171494 0.766 0 0
PKR-mediated signaling R-HSA-9833482 0.526606 0.279 0 0
Signal transduction by L1 R-HSA-445144 0.460941 0.336 0 0
NGF-stimulated transcription R-HSA-9031628 0.336096 0.474 0 0
MHC class II antigen presentation R-HSA-2132295 0.310460 0.508 0 0
FLT3 signaling in disease R-HSA-9682385 0.435679 0.361 0 0
Formation of the anterior neural plate R-HSA-9823739 0.299994 0.523 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.400712 0.397 0 0
Activation of BH3-only proteins R-HSA-114452 0.490477 0.309 0 0
Signaling by NTRKs R-HSA-166520 0.319270 0.496 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 0.331659 0.479 0 0
G1/S-Specific Transcription R-HSA-69205 0.073074 1.136 0 0
Regulation of KIT signaling R-HSA-1433559 0.272855 0.564 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.327259 0.485 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.290185 0.537 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 0.506010 0.296 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.201747 0.695 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.337436 0.472 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.337436 0.472 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.355049 0.450 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 0.553365 0.257 0 0
Relaxin receptors R-HSA-444821 0.553365 0.257 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 0.553365 0.257 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 0.596183 0.225 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.493189 0.307 0 0
Glucose metabolism R-HSA-70326 0.448490 0.348 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 0.598082 0.223 0 0
Regulation of PTEN localization R-HSA-8948747 0.634898 0.197 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.326437 0.486 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.525480 0.279 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.596571 0.224 0 0
Apoptosis R-HSA-109581 0.450062 0.347 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.566139 0.247 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.585413 0.233 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.604723 0.218 0 0
Interleukin-7 signaling R-HSA-1266695 0.603925 0.219 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.415586 0.381 0 0
IRE1alpha activates chaperones R-HSA-381070 0.092131 1.036 0 0
Inositol phosphate metabolism R-HSA-1483249 0.593789 0.226 0 0
Maturation of nucleoprotein R-HSA-9683610 0.246001 0.609 0 0
Growth hormone receptor signaling R-HSA-982772 0.335075 0.475 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.337457 0.472 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 0.246001 0.609 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.299994 0.523 0 0
Formation of intermediate mesoderm R-HSA-9761174 0.376564 0.424 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.290185 0.537 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 0.411735 0.385 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.506010 0.296 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.302553 0.519 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 0.553365 0.257 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 0.553365 0.257 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 0.553365 0.257 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.460765 0.337 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.511316 0.291 0 0
HDL clearance R-HSA-8964011 0.596183 0.225 0 0
Nef and signal transduction R-HSA-164944 0.596183 0.225 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.559087 0.253 0 0
CHL1 interactions R-HSA-447041 0.634898 0.197 0 0
CREB3 factors activate genes R-HSA-8874211 0.596183 0.225 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 0.570314 0.244 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.465175 0.332 0 0
Regulation of gene expression in beta cells R-HSA-210745 0.279267 0.554 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.583525 0.234 0 0
Signaling by Leptin R-HSA-2586552 0.376564 0.424 0 0
ChREBP activates metabolic gene expression R-HSA-163765 0.411735 0.385 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.402702 0.395 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.105535 0.977 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 0.506010 0.296 0 0
Maturation of nucleoprotein R-HSA-9694631 0.434922 0.362 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 0.553365 0.257 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.313596 0.504 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.484446 0.315 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 0.634898 0.197 0 0
Regulation of beta-cell development R-HSA-186712 0.363818 0.439 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.579821 0.237 0 0
Interleukin-37 signaling R-HSA-9008059 0.159287 0.798 0 0
Response to metal ions R-HSA-5660526 0.624479 0.204 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.124367 0.905 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 0.203959 0.690 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 0.312557 0.505 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.635559 0.197 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.641420 0.193 0 0
Signaling by ROBO receptors R-HSA-376176 0.643095 0.192 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.644176 0.191 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.645636 0.190 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.645636 0.190 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.645636 0.190 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.645636 0.190 0 0
Signaling by BMP R-HSA-201451 0.645636 0.190 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.645636 0.190 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 0.645636 0.190 0 0
Insulin processing R-HSA-264876 0.645636 0.190 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 0.649510 0.187 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.649510 0.187 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.649510 0.187 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 0.649510 0.187 0 0
Uptake and function of anthrax toxins R-HSA-5210891 0.649510 0.187 0 0
MAPK family signaling cascades R-HSA-5683057 0.651033 0.186 0 0
Gene Silencing by RNA R-HSA-211000 0.652124 0.186 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.652124 0.186 0 0
Signaling by ALK in cancer R-HSA-9700206 0.652124 0.186 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.652570 0.185 0 0
L1CAM interactions R-HSA-373760 0.657200 0.182 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.657960 0.182 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.657960 0.182 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.657960 0.182 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.662651 0.179 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.662651 0.179 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.663215 0.178 0 0
Intraflagellar transport R-HSA-5620924 0.664407 0.178 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 0.665289 0.177 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.665289 0.177 0 0
HIV elongation arrest and recovery R-HSA-167287 0.665289 0.177 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.665289 0.177 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.665289 0.177 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.665289 0.177 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.665289 0.177 0 0
Extension of Telomeres R-HSA-180786 0.666549 0.176 0 0
COPII-mediated vesicle transport R-HSA-204005 0.669379 0.174 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.669379 0.174 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 0.669904 0.174 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 0.669904 0.174 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 0.669904 0.174 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 0.669904 0.174 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 0.669904 0.174 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 0.669904 0.174 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 0.669904 0.174 0 0
Regulation by c-FLIP R-HSA-3371378 0.669904 0.174 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 0.669904 0.174 0 0
Dimerization of procaspase-8 R-HSA-69416 0.669904 0.174 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 0.669904 0.174 0 0
Sodium/Proton exchangers R-HSA-425986 0.669904 0.174 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 0.669904 0.174 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.672996 0.172 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.673196 0.172 0 0
PKA activation R-HSA-163615 0.673196 0.172 0 0
PKA activation in glucagon signalling R-HSA-164378 0.673196 0.172 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.673196 0.172 0 0
Synaptic adhesion-like molecules R-HSA-8849932 0.673196 0.172 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 0.673196 0.172 0 0
Apoptotic factor-mediated response R-HSA-111471 0.673196 0.172 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.673196 0.172 0 0
Nephron development R-HSA-9831926 0.673196 0.172 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.676018 0.170 0 0
Hedgehog 'off' state R-HSA-5610787 0.679560 0.168 0 0
Stabilization of p53 R-HSA-69541 0.680089 0.167 0 0
Signaling by ALK R-HSA-201556 0.680089 0.167 0 0
Signaling by ERBB2 R-HSA-1227986 0.680168 0.167 0 0
tRNA Aminoacylation R-HSA-379724 0.680168 0.167 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.681989 0.166 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 0.684134 0.165 0 0
mRNA Capping R-HSA-72086 0.684134 0.165 0 0
Signaling by Erythropoietin R-HSA-9006335 0.684134 0.165 0 0
DARPP-32 events R-HSA-180024 0.684134 0.165 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 0.684134 0.165 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.686763 0.163 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.686763 0.163 0 0
MAP kinase activation R-HSA-450294 0.693420 0.159 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.694290 0.158 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.694290 0.158 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.695564 0.158 0 0
Specification of the neural plate border R-HSA-9834899 0.695564 0.158 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 0.695564 0.158 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.695564 0.158 0 0
The NLRP3 inflammasome R-HSA-844456 0.695564 0.158 0 0
Other interleukin signaling R-HSA-449836 0.695564 0.158 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.696052 0.157 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.696052 0.157 0 0
Diseases of Immune System R-HSA-5260271 0.696052 0.157 0 0
S Phase R-HSA-69242 0.697465 0.156 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.700325 0.155 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.700325 0.155 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 0.701555 0.154 0 0
MAPK1 (ERK2) activation R-HSA-112411 0.701555 0.154 0 0
CASP8 activity is inhibited R-HSA-5218900 0.701555 0.154 0 0
p75NTR regulates axonogenesis R-HSA-193697 0.701555 0.154 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 0.701555 0.154 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 0.701555 0.154 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 0.701555 0.154 0 0
Interleukin-1 processing R-HSA-448706 0.701555 0.154 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 0.701555 0.154 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 0.701555 0.154 0 0
Regulation of signaling by NODAL R-HSA-1433617 0.701555 0.154 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 0.701555 0.154 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.701555 0.154 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.701555 0.154 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 0.701555 0.154 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.702176 0.154 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.702176 0.154 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.705609 0.151 0 0
HSF1-dependent transactivation R-HSA-3371571 0.707710 0.150 0 0
Toll-like Receptor Cascades R-HSA-168898 0.711108 0.148 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.711436 0.148 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.714765 0.146 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.714765 0.146 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 0.716649 0.145 0 0
Signaling by ERBB4 R-HSA-1236394 0.717950 0.144 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.718099 0.144 0 0
Budding and maturation of HIV virion R-HSA-162588 0.719420 0.143 0 0
Downstream signal transduction R-HSA-186763 0.719420 0.143 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.720229 0.143 0 0
Neurexins and neuroligins R-HSA-6794361 0.721239 0.142 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.721239 0.142 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.726242 0.139 0 0
HIV Transcription Initiation R-HSA-167161 0.726242 0.139 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 0.726242 0.139 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.726242 0.139 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.727495 0.138 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.729050 0.137 0 0
Protein ubiquitination R-HSA-8852135 0.729304 0.137 0 0
MAPK3 (ERK1) activation R-HSA-110056 0.730173 0.137 0 0
Folding of actin by CCT/TriC R-HSA-390450 0.730173 0.137 0 0
PI3K/AKT activation R-HSA-198203 0.730173 0.137 0 0
Binding and entry of HIV virion R-HSA-173107 0.730173 0.137 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 0.730173 0.137 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 0.730173 0.137 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 0.730173 0.137 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 0.730173 0.137 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.730173 0.137 0 0
Arachidonate production from DAG R-HSA-426048 0.730173 0.137 0 0
Serotonin receptors R-HSA-390666 0.730173 0.137 0 0
Tandem pore domain potassium channels R-HSA-1296346 0.730173 0.137 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.734315 0.134 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.735878 0.133 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.736492 0.133 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.736492 0.133 0 0
G-protein activation R-HSA-202040 0.736492 0.133 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 0.736492 0.133 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 0.736492 0.133 0 0
Lagging Strand Synthesis R-HSA-69186 0.736492 0.133 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.736492 0.133 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.736492 0.133 0 0
ERK/MAPK targets R-HSA-198753 0.736492 0.133 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.740033 0.131 0 0
Activation of GABAB receptors R-HSA-991365 0.740475 0.130 0 0
GABA B receptor activation R-HSA-977444 0.740475 0.130 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 0.740475 0.130 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.740647 0.130 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.742172 0.129 0 0
Interferon Signaling R-HSA-913531 0.742717 0.129 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.748553 0.126 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.749339 0.125 0 0
G1/S Transition R-HSA-69206 0.749565 0.125 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.751054 0.124 0 0
Nuclear RNA decay R-HSA-9930044 0.751562 0.124 0 0
Recycling of bile acids and salts R-HSA-159418 0.751562 0.124 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.754138 0.123 0 0
Signaling by FGFR4 R-HSA-5654743 0.754138 0.123 0 0
Signaling by SCF-KIT R-HSA-1433557 0.754138 0.123 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.755136 0.122 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.755136 0.122 0 0
Mitochondrial calcium ion transport R-HSA-8949215 0.755136 0.122 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.755136 0.122 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.755136 0.122 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.755136 0.122 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.756048 0.121 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 0.756048 0.121 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 0.756048 0.121 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 0.756048 0.121 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 0.756048 0.121 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.756048 0.121 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 0.756048 0.121 0 0
Synthesis of PI R-HSA-1483226 0.756048 0.121 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 0.756048 0.121 0 0
PECAM1 interactions R-HSA-210990 0.756048 0.121 0 0
G alpha (z) signalling events R-HSA-418597 0.759112 0.120 0 0
Kidney development R-HSA-9830369 0.765110 0.116 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.766489 0.115 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.766489 0.115 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.766489 0.115 0 0
Heme degradation R-HSA-189483 0.766489 0.115 0 0
Signaling by FGFR R-HSA-190236 0.767066 0.115 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.772214 0.112 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 0.772629 0.112 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.772629 0.112 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.772629 0.112 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.775755 0.110 0 0
DS-GAG biosynthesis R-HSA-2022923 0.779444 0.108 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 0.779444 0.108 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 0.779444 0.108 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 0.779444 0.108 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 0.779444 0.108 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 0.779444 0.108 0 0
Sodium/Calcium exchangers R-HSA-425561 0.779444 0.108 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 0.779444 0.108 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.779790 0.108 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 0.779790 0.108 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.780676 0.108 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 0.780676 0.108 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 0.780676 0.108 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.780676 0.108 0 0
Signaling by FGFR2 R-HSA-5654738 0.781290 0.107 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.781290 0.107 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.781290 0.107 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.785437 0.105 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 0.789021 0.103 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 0.789021 0.103 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 0.789021 0.103 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 0.789021 0.103 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.789021 0.103 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.789021 0.103 0 0
Formation of the ureteric bud R-HSA-9830674 0.789021 0.103 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.789758 0.103 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.790578 0.102 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.791796 0.101 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.791796 0.101 0 0
Dual incision in TC-NER R-HSA-6782135 0.792979 0.101 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.795949 0.099 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.795949 0.099 0 0
Interleukin-17 signaling R-HSA-448424 0.795949 0.099 0 0
Generic Transcription Pathway R-HSA-212436 0.796211 0.099 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.796377 0.099 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.800597 0.097 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 0.800597 0.097 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 0.800597 0.097 0 0
Polymerase switching R-HSA-69091 0.800597 0.097 0 0
Leading Strand Synthesis R-HSA-69109 0.800597 0.097 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.800597 0.097 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 0.800597 0.097 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 0.800597 0.097 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 0.800597 0.097 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.800597 0.097 0 0
Synthesis of GDP-mannose R-HSA-446205 0.800597 0.097 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.800597 0.097 0 0
Pervasive developmental disorders R-HSA-9005895 0.800597 0.097 0 0
Disorders of Nervous System Development R-HSA-9697154 0.800597 0.097 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 0.800597 0.097 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 0.800597 0.097 0 0
Estrogen biosynthesis R-HSA-193144 0.800597 0.097 0 0
Interleukin-15 signaling R-HSA-8983432 0.800597 0.097 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.801133 0.096 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.802186 0.096 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.803272 0.095 0 0
Protein folding R-HSA-391251 0.804323 0.095 0 0
Signaling by Insulin receptor R-HSA-74752 0.804323 0.095 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.804361 0.095 0 0
Thromboxane signalling through TP receptor R-HSA-428930 0.804361 0.095 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.804361 0.095 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 0.804361 0.095 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.804361 0.095 0 0
Neurodegenerative Diseases R-HSA-8863678 0.804361 0.095 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.804361 0.095 0 0
Mitochondrial RNA degradation R-HSA-9836573 0.804361 0.095 0 0
TNFs bind their physiological receptors R-HSA-5669034 0.804361 0.095 0 0
Interleukin-6 family signaling R-HSA-6783589 0.804361 0.095 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.806916 0.093 0 0
RNA Polymerase III Transcription R-HSA-74158 0.806916 0.093 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.806916 0.093 0 0
Calmodulin induced events R-HSA-111933 0.806916 0.093 0 0
CaM pathway R-HSA-111997 0.806916 0.093 0 0
Interleukin-1 family signaling R-HSA-446652 0.808541 0.092 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.813408 0.090 0 0
GPER1 signaling R-HSA-9634597 0.814228 0.089 0 0
Metal ion SLC transporters R-HSA-425410 0.814228 0.089 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.814713 0.089 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.816712 0.088 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 0.818701 0.087 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.818701 0.087 0 0
Laminin interactions R-HSA-3000157 0.818701 0.087 0 0
Formation of the nephric duct R-HSA-9830364 0.818701 0.087 0 0
Degradation of DVL R-HSA-4641258 0.819012 0.087 0 0
Adenylate cyclase activating pathway R-HSA-170660 0.819722 0.086 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.819722 0.086 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.819722 0.086 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 0.819722 0.086 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 0.819722 0.086 0 0
Processing of SMDT1 R-HSA-8949664 0.819722 0.086 0 0
CD28 dependent Vav1 pathway R-HSA-389359 0.819722 0.086 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 0.819722 0.086 0 0
Interleukin-6 signaling R-HSA-1059683 0.819722 0.086 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 0.819722 0.086 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.823000 0.085 0 0
Aquaporin-mediated transport R-HSA-445717 0.823000 0.085 0 0
DNA Damage Bypass R-HSA-73893 0.824679 0.084 0 0
Degradation of CDH1 R-HSA-9766229 0.824679 0.084 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.824679 0.084 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.824679 0.084 0 0
Gap junction trafficking and regulation R-HSA-157858 0.824679 0.084 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.825463 0.083 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.829574 0.081 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 0.832091 0.080 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.832091 0.080 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.832091 0.080 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.832091 0.080 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.832091 0.080 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 0.832091 0.080 0 0
Urea cycle R-HSA-70635 0.832091 0.080 0 0
Mitochondrial protein import R-HSA-1268020 0.832191 0.080 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.834638 0.079 0 0
CRMPs in Sema3A signaling R-HSA-399956 0.837014 0.077 0 0
NRIF signals cell death from the nucleus R-HSA-205043 0.837014 0.077 0 0
FGFR3c ligand binding and activation R-HSA-190372 0.837014 0.077 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 0.837014 0.077 0 0
Physiological factors R-HSA-5578768 0.837014 0.077 0 0
Zinc transporters R-HSA-435354 0.837014 0.077 0 0
Prolactin receptor signaling R-HSA-1170546 0.837014 0.077 0 0
Malate-aspartate shuttle R-HSA-9856872 0.837014 0.077 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 0.837014 0.077 0 0
Ciprofloxacin ADME R-HSA-9793528 0.837014 0.077 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 0.837014 0.077 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.840344 0.076 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.840988 0.075 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.841275 0.075 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.841298 0.075 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.842273 0.075 0 0
Potassium Channels R-HSA-1296071 0.842747 0.074 0 0
SARS-CoV Infections R-HSA-9679506 0.842815 0.074 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.844120 0.074 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.844582 0.073 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.844582 0.073 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.844582 0.073 0 0
Ion transport by P-type ATPases R-HSA-936837 0.849402 0.071 0 0
Telomere Maintenance R-HSA-157579 0.849665 0.071 0 0
Interferon gamma signaling R-HSA-877300 0.849886 0.071 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.851490 0.070 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.851490 0.070 0 0
HIV Transcription Elongation R-HSA-167169 0.851490 0.070 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.851490 0.070 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.851490 0.070 0 0
Generation of second messenger molecules R-HSA-202433 0.851490 0.070 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.852649 0.069 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 0.852649 0.069 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.852649 0.069 0 0
Telomere C-strand synthesis initiation R-HSA-174430 0.852649 0.069 0 0
Protein lipoylation R-HSA-9857492 0.852649 0.069 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.852649 0.069 0 0
DCC mediated attractive signaling R-HSA-418885 0.852649 0.069 0 0
Signaling by Activin R-HSA-1502540 0.852649 0.069 0 0
DNA Damage Reversal R-HSA-73942 0.852649 0.069 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.852649 0.069 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.852649 0.069 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 0.852649 0.069 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 0.852649 0.069 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.852649 0.069 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.852649 0.069 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.853140 0.069 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.853140 0.069 0 0
Telomere Extension By Telomerase R-HSA-171319 0.856222 0.067 0 0
Inflammasomes R-HSA-622312 0.856222 0.067 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.856338 0.067 0 0
Metabolism of RNA R-HSA-8953854 0.859742 0.066 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.861127 0.065 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.861127 0.065 0 0
Synthesis of bile acids and bile salts R-HSA-192105 0.862771 0.064 0 0
HIV Infection R-HSA-162906 0.863284 0.064 0 0
TCR signaling R-HSA-202403 0.863957 0.064 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 0.866784 0.062 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 0.866784 0.062 0 0
Phase 4 - resting membrane potential R-HSA-5576886 0.866784 0.062 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 0.866784 0.062 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 0.866784 0.062 0 0
Fructose catabolism R-HSA-70350 0.866784 0.062 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.866784 0.062 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.866784 0.062 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.866784 0.062 0 0
Differentiation of T cells R-HSA-9945266 0.866784 0.062 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.867060 0.062 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.867060 0.062 0 0
Platelet calcium homeostasis R-HSA-418360 0.867060 0.062 0 0
Glucagon-type ligand receptors R-HSA-420092 0.867060 0.062 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.867060 0.062 0 0
Translation of Structural Proteins R-HSA-9683701 0.870209 0.060 0 0
Interleukin-1 signaling R-HSA-9020702 0.874935 0.058 0 0
Activation of the pre-replicative complex R-HSA-68962 0.877143 0.057 0 0
DAP12 signaling R-HSA-2424491 0.877143 0.057 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.877143 0.057 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.877143 0.057 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.877143 0.057 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 0.877143 0.057 0 0
Neurotransmitter clearance R-HSA-112311 0.877143 0.057 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 0.877143 0.057 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.877577 0.057 0 0
Ca-dependent events R-HSA-111996 0.878763 0.056 0 0
Transcription of the HIV genome R-HSA-167172 0.879438 0.056 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.879438 0.056 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 0.879564 0.056 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.879564 0.056 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 0.879564 0.056 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 0.879564 0.056 0 0
Scavenging by Class B Receptors R-HSA-3000471 0.879564 0.056 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 0.879564 0.056 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 0.879564 0.056 0 0
Signaling by WNT R-HSA-195721 0.880656 0.055 0 0
Amyloid fiber formation R-HSA-977225 0.882824 0.054 0 0
Signaling by FGFR1 R-HSA-5654736 0.884901 0.053 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 0.886516 0.052 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 0.886516 0.052 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.886516 0.052 0 0
Co-inhibition by PD-1 R-HSA-389948 0.886949 0.052 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.891119 0.050 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 0.891119 0.050 0 0
Glycogen storage diseases R-HSA-3229121 0.891119 0.050 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 0.891119 0.050 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 0.891119 0.050 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 0.891119 0.050 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 0.891119 0.050 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.891119 0.050 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.891119 0.050 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 0.891119 0.050 0 0
Opioid Signalling R-HSA-111885 0.891508 0.050 0 0
Muscle contraction R-HSA-397014 0.893218 0.049 0 0
G1 Phase R-HSA-69236 0.894380 0.048 0 0
Cyclin D associated events in G1 R-HSA-69231 0.894380 0.048 0 0
Gap junction trafficking R-HSA-190828 0.894380 0.048 0 0
DNA strand elongation R-HSA-69190 0.895222 0.048 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.898409 0.047 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.898471 0.046 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.898471 0.046 0 0
Hedgehog 'on' state R-HSA-5632684 0.898471 0.046 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.900236 0.046 0 0
Integration of energy metabolism R-HSA-163685 0.901279 0.045 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 0.901490 0.045 0 0
DAG and IP3 signaling R-HSA-1489509 0.901490 0.045 0 0
GAB1 signalosome R-HSA-180292 0.901566 0.045 0 0
Transport of connexons to the plasma membrane R-HSA-190872 0.901566 0.045 0 0
Tie2 Signaling R-HSA-210993 0.901566 0.045 0 0
Platelet sensitization by LDL R-HSA-432142 0.901566 0.045 0 0
Mismatch Repair R-HSA-5358508 0.901566 0.045 0 0
Axon guidance R-HSA-422475 0.902823 0.044 0 0
Defective B3GALTL causes PpS R-HSA-5083635 0.903302 0.044 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 0.903302 0.044 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.903302 0.044 0 0
Cardiogenesis R-HSA-9733709 0.903302 0.044 0 0
Platelet homeostasis R-HSA-418346 0.906205 0.043 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.906786 0.042 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.908165 0.042 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.908165 0.042 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.908165 0.042 0 0
Signaling by TGFBR3 R-HSA-9839373 0.908165 0.042 0 0
Signaling by Hedgehog R-HSA-5358351 0.909466 0.041 0 0
GABA receptor activation R-HSA-977443 0.910500 0.041 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.910798 0.041 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.910798 0.041 0 0
Glutamate and glutamine metabolism R-HSA-8964539 0.910798 0.041 0 0
Translesion Synthesis by POLH R-HSA-110320 0.911011 0.040 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 0.911011 0.040 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 0.911011 0.040 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.911011 0.040 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 0.911011 0.040 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 0.911011 0.040 0 0
Nervous system development R-HSA-9675108 0.912625 0.040 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.913909 0.039 0 0
Recycling pathway of L1 R-HSA-437239 0.914427 0.039 0 0
PLC beta mediated events R-HSA-112043 0.916052 0.038 0 0
Dual Incision in GG-NER R-HSA-5696400 0.917746 0.037 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 0.917746 0.037 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.917746 0.037 0 0
Signal amplification R-HSA-392518 0.917746 0.037 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.917746 0.037 0 0
Signaling by NOTCH2 R-HSA-1980145 0.917746 0.037 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.917746 0.037 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.917746 0.037 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 0.919550 0.036 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 0.919550 0.036 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 0.919550 0.036 0 0
Co-inhibition by CTLA4 R-HSA-389513 0.919550 0.036 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 0.919550 0.036 0 0
Glycogen synthesis R-HSA-3322077 0.919550 0.036 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 0.919550 0.036 0 0
Keratan sulfate degradation R-HSA-2022857 0.919550 0.036 0 0
Creatine metabolism R-HSA-71288 0.919550 0.036 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 0.919550 0.036 0 0
Co-stimulation by CD28 R-HSA-389356 0.920298 0.036 0 0
Gluconeogenesis R-HSA-70263 0.920298 0.036 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.921294 0.036 0 0
Signaling by PDGF R-HSA-186797 0.921294 0.036 0 0
Bile acid and bile salt metabolism R-HSA-194068 0.923143 0.035 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.924182 0.034 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.924182 0.034 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 0.924182 0.034 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.924182 0.034 0 0
FOXO-mediated transcription R-HSA-9614085 0.925299 0.034 0 0
Signalling to RAS R-HSA-167044 0.927270 0.033 0 0
HSF1 activation R-HSA-3371511 0.930141 0.031 0 0
RET signaling R-HSA-8853659 0.930141 0.031 0 0
GPVI-mediated activation cascade R-HSA-114604 0.930141 0.031 0 0
Triglyceride catabolism R-HSA-163560 0.930141 0.031 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.930141 0.031 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.930418 0.031 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.931636 0.031 0 0
Downstream TCR signaling R-HSA-202424 0.932431 0.030 0 0
CS-GAG biosynthesis R-HSA-2022870 0.934250 0.030 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 0.934250 0.030 0 0
Attachment and Entry R-HSA-9694614 0.934250 0.030 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 0.934250 0.030 0 0
Assembly Of The HIV Virion R-HSA-175474 0.934250 0.030 0 0
Glutathione synthesis and recycling R-HSA-174403 0.934250 0.030 0 0
Phospholipid metabolism R-HSA-1483257 0.935177 0.029 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.935300 0.029 0 0
Host Interactions of HIV factors R-HSA-162909 0.935647 0.029 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 0.935655 0.029 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.935655 0.029 0 0
Metabolism of folate and pterines R-HSA-196757 0.935655 0.029 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.936188 0.029 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.940275 0.027 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.940546 0.027 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 0.940561 0.027 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.940561 0.027 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.940561 0.027 0 0
Fructose metabolism R-HSA-5652084 0.940561 0.027 0 0
Reactions specific to the complex N-glycan synthesis pathway R-HSA-975578 0.940561 0.027 0 0
Ethanol oxidation R-HSA-71384 0.940561 0.027 0 0
Signaling by KIT in disease R-HSA-9669938 0.940561 0.027 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.940561 0.027 0 0
G-protein mediated events R-HSA-112040 0.943339 0.025 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 0.943339 0.025 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.943959 0.025 0 0
HCMV Early Events R-HSA-9609690 0.946172 0.024 0 0
Termination of O-glycan biosynthesis R-HSA-977068 0.946266 0.024 0 0
Mitochondrial mRNA modification R-HSA-9937008 0.946266 0.024 0 0
Organic anion transport by SLCO transporters R-HSA-879518 0.946266 0.024 0 0
Interleukin-20 family signaling R-HSA-8854691 0.946266 0.024 0 0
Platelet degranulation R-HSA-114608 0.947334 0.023 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.947663 0.023 0 0
Translation initiation complex formation R-HSA-72649 0.948422 0.023 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.948422 0.023 0 0
Attenuation phase R-HSA-3371568 0.949824 0.022 0 0
Glycogen metabolism R-HSA-8982491 0.949824 0.022 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 0.949824 0.022 0 0
Interleukin-2 family signaling R-HSA-451927 0.949824 0.022 0 0
Potential therapeutics for SARS R-HSA-9679191 0.949912 0.022 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.949956 0.022 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.950455 0.022 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 0.951424 0.022 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 0.951424 0.022 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 0.951424 0.022 0 0
Complex III assembly R-HSA-9865881 0.951424 0.022 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.951424 0.022 0 0
Paracetamol ADME R-HSA-9753281 0.952096 0.021 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.953846 0.021 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.955524 0.020 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.955524 0.020 0 0
Ion homeostasis R-HSA-5578775 0.955524 0.020 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 0.956086 0.020 0 0
Tight junction interactions R-HSA-420029 0.956086 0.020 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.956086 0.020 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 0.956086 0.020 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 0.956086 0.020 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 0.956086 0.020 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.956342 0.019 0 0
Protein localization R-HSA-9609507 0.956604 0.019 0 0
Stimuli-sensing channels R-HSA-2672351 0.956904 0.019 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.957558 0.019 0 0
Intra-Golgi traffic R-HSA-6811438 0.957558 0.019 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 0.957558 0.019 0 0
TRP channels R-HSA-3295583 0.960302 0.018 0 0
Sphingolipid catabolism R-HSA-9845614 0.960302 0.018 0 0
Abacavir ADME R-HSA-2161522 0.960302 0.018 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.960523 0.017 0 0
Influenza Infection R-HSA-168255 0.960867 0.017 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.960984 0.017 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.960984 0.017 0 0
Depyrimidination R-HSA-73928 0.960984 0.017 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.961702 0.017 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.962284 0.017 0 0
Regulation of insulin secretion R-HSA-422356 0.962470 0.017 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.963341 0.016 0 0
Packaging Of Telomere Ends R-HSA-171306 0.964113 0.016 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 0.964113 0.016 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 0.964113 0.016 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.964113 0.016 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 0.964113 0.016 0 0
Synthesis of PE R-HSA-1483213 0.964113 0.016 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.964480 0.016 0 0
Signaling by NOTCH4 R-HSA-9013694 0.964801 0.016 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.965732 0.015 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.965732 0.015 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.966691 0.015 0 0
tRNA processing R-HSA-72306 0.966691 0.015 0 0
DAP12 interactions R-HSA-2172127 0.967055 0.015 0 0
Netrin-1 signaling R-HSA-373752 0.967055 0.015 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 0.967055 0.015 0 0
RAB geranylgeranylation R-HSA-8873719 0.967067 0.015 0 0
Signaling by Retinoic Acid R-HSA-5362517 0.967067 0.015 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.967559 0.014 0 0
Insulin receptor recycling R-HSA-77387 0.967559 0.014 0 0
Pyrimidine salvage R-HSA-73614 0.967559 0.014 0 0
Interleukin-12 signaling R-HSA-9020591 0.969373 0.014 0 0
Endogenous sterols R-HSA-211976 0.969475 0.013 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.969475 0.013 0 0
Collagen degradation R-HSA-1442490 0.969475 0.013 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.969739 0.013 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.969739 0.013 0 0
Neddylation R-HSA-8951664 0.970317 0.013 0 0
Base Excision Repair R-HSA-73884 0.970565 0.013 0 0
DNA methylation R-HSA-5334118 0.970674 0.013 0 0
Translation of Structural Proteins R-HSA-9694635 0.971445 0.013 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.971716 0.012 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.972211 0.012 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.972211 0.012 0 0
PCP/CE pathway R-HSA-4086400 0.973385 0.012 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 0.973490 0.012 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.974356 0.011 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.974443 0.011 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.974488 0.011 0 0
HCMV Infection R-HSA-9609646 0.975664 0.011 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.975844 0.011 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.975920 0.011 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.975920 0.011 0 0
Trafficking of AMPA receptors R-HSA-399719 0.976035 0.011 0 0
Molecules associated with elastic fibres R-HSA-2129379 0.976035 0.011 0 0
Aspartate and asparagine metabolism R-HSA-8963693 0.976035 0.011 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.977454 0.010 0 0
Cellular response to hypoxia R-HSA-1234174 0.977540 0.010 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 0.978337 0.010 0 0
HS-GAG degradation R-HSA-2024096 0.978337 0.010 0 0
Chemokine receptors bind chemokines R-HSA-380108 0.978513 0.009 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 0.978513 0.009 0 0
Synthesis of DNA R-HSA-69239 0.979817 0.009 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.980230 0.009 0 0
Keratan sulfate biosynthesis R-HSA-2022854 0.980417 0.009 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.980417 0.009 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.981061 0.008 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.981061 0.008 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.981518 0.008 0 0
HCMV Late Events R-HSA-9610379 0.981677 0.008 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.981920 0.008 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.982198 0.008 0 0
CS/DS degradation R-HSA-2024101 0.982298 0.008 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 0.982298 0.008 0 0
Orc1 removal from chromatin R-HSA-68949 0.983420 0.007 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.983420 0.007 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.983420 0.007 0 0
Developmental Biology R-HSA-1266738 0.983713 0.007 0 0
Gap junction assembly R-HSA-190861 0.983998 0.007 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.983998 0.007 0 0
RA biosynthesis pathway R-HSA-5365859 0.983998 0.007 0 0
Calnexin/calreticulin cycle R-HSA-901042 0.983998 0.007 0 0
eNOS activation R-HSA-203615 0.983998 0.007 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.984799 0.007 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.985535 0.006 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.985943 0.006 0 0
Metabolism of porphyrins R-HSA-189445 0.985943 0.006 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.986066 0.006 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.986066 0.006 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.986278 0.006 0 0
Signaling by VEGF R-HSA-194138 0.986919 0.006 0 0
HS-GAG biosynthesis R-HSA-2022928 0.986925 0.006 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.986925 0.006 0 0
Interleukin-12 family signaling R-HSA-447115 0.987043 0.006 0 0
Ion channel transport R-HSA-983712 0.987201 0.006 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.987231 0.006 0 0
Selenocysteine synthesis R-HSA-2408557 0.987734 0.005 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.987734 0.005 0 0
Peptide chain elongation R-HSA-156902 0.987961 0.005 0 0
Degradation of AXIN R-HSA-4641257 0.988181 0.005 0 0
Cleavage of the damaged purine R-HSA-110331 0.988181 0.005 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.988181 0.005 0 0
SLC-mediated transport of organic cations R-HSA-549127 0.988181 0.005 0 0
Collagen chain trimerization R-HSA-8948216 0.988181 0.005 0 0
ER-Phagosome pathway R-HSA-1236974 0.988817 0.005 0 0
Depurination R-HSA-73927 0.989316 0.005 0 0
Elastic fibre formation R-HSA-1566948 0.989316 0.005 0 0
Purine salvage R-HSA-74217 0.989316 0.005 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 0.989316 0.005 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.989316 0.005 0 0
Signaling by Interleukins R-HSA-449147 0.989592 0.005 0 0
Neurotransmitter release cycle R-HSA-112310 0.989614 0.005 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 0.989614 0.005 0 0
Pentose phosphate pathway R-HSA-71336 0.990343 0.004 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.990343 0.004 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.990357 0.004 0 0
Adaptive Immune System R-HSA-1280218 0.990915 0.004 0 0
Peroxisomal protein import R-HSA-9033241 0.991010 0.004 0 0
Triglyceride metabolism R-HSA-8979227 0.991010 0.004 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.991049 0.004 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.991271 0.004 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.991271 0.004 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 0.991271 0.004 0 0
N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975576 0.991271 0.004 0 0
Transmission across Chemical Synapses R-HSA-112315 0.991353 0.004 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.991694 0.004 0 0
Metabolism of steroids R-HSA-8957322 0.991725 0.004 0 0
Maturation of spike protein R-HSA-9694548 0.992109 0.003 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 0.992109 0.003 0 0
Aflatoxin activation and detoxification R-HSA-5423646 0.992109 0.003 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.992293 0.003 0 0
Developmental Cell Lineages R-HSA-9734767 0.992411 0.003 0 0
Nucleotide salvage R-HSA-8956321 0.992464 0.003 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.992485 0.003 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.992852 0.003 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.992868 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 0.992868 0.003 0 0
Heme biosynthesis R-HSA-189451 0.992868 0.003 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.993103 0.003 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.993345 0.003 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.993828 0.003 0 0
Eukaryotic Translation Termination R-HSA-72764 0.993854 0.003 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.993983 0.003 0 0
Mitochondrial translation elongation R-HSA-5389840 0.994303 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 0.994733 0.002 0 0
Amine ligand-binding receptors R-HSA-375280 0.994733 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.995167 0.002 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.995239 0.002 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.995239 0.002 0 0
SLC transporter disorders R-HSA-5619102 0.995342 0.002 0 0
Nicotinate metabolism R-HSA-196807 0.995580 0.002 0 0
Parasite infection R-HSA-9664407 0.995617 0.002 0 0
Leishmania phagocytosis R-HSA-9664417 0.995617 0.002 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.995617 0.002 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 0.995697 0.002 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.995803 0.002 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 0.996110 0.002 0 0
Synthesis of PC R-HSA-1483191 0.996110 0.002 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 0.996110 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.996134 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.996340 0.002 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.996442 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 0.996484 0.002 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.996484 0.002 0 0
Viral mRNA Translation R-HSA-192823 0.996669 0.001 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.996686 0.001 0 0
Neuronal System R-HSA-112316 0.996763 0.001 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 0.996822 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.996822 0.001 0 0
Cardiac conduction R-HSA-5576891 0.996906 0.001 0 0
ECM proteoglycans R-HSA-3000178 0.996912 0.001 0 0
Leishmania infection R-HSA-9658195 0.996915 0.001 0 0
Parasitic Infection Pathways R-HSA-9824443 0.996915 0.001 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.997128 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 0.997128 0.001 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.997404 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 0.997404 0.001 0 0
The phototransduction cascade R-HSA-2514856 0.997404 0.001 0 0
rRNA processing R-HSA-72312 0.997601 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.997646 0.001 0 0
Selenoamino acid metabolism R-HSA-2408522 0.997758 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 0.997847 0.001 0 0
Iron uptake and transport R-HSA-917937 0.997847 0.001 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.997879 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 0.997879 0.001 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.997913 0.001 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.998071 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 0.998117 0.001 0 0
Collagen formation R-HSA-1474290 0.998170 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.998177 0.001 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.998177 0.001 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 0.998268 0.001 0 0
DNA Replication R-HSA-69306 0.998298 0.001 0 0
Antimicrobial peptides R-HSA-6803157 0.998352 0.001 0 0
Integrin cell surface interactions R-HSA-216083 0.998359 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 0.998359 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 0.998359 0.001 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.998434 0.001 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.998453 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.998478 0.001 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 0.998502 0.001 0 0
Dectin-2 family R-HSA-5621480 0.998585 0.001 0 0
Synthesis of PA R-HSA-1483166 0.998585 0.001 0 0
G alpha (s) signalling events R-HSA-418555 0.998682 0.001 0 0
Viral Infection Pathways R-HSA-9824446 0.998757 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 0.998799 0.001 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 0.998844 0.001 0 0
Glutathione conjugation R-HSA-156590 0.998955 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.998959 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.999215 0.000 0 0
Post-translational protein modification R-HSA-597592 0.999223 0.000 0 0
Neutrophil degranulation R-HSA-6798695 0.999433 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 0.999484 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 0.999485 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 0.999535 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.999535 0.000 0 0
Extracellular matrix organization R-HSA-1474244 0.999567 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 0.999569 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 0.999620 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.999621 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 0.999657 0.000 0 0
Metabolism of cofactors R-HSA-8978934 0.999657 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 0.999690 0.000 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.999690 0.000 0 0
Purine catabolism R-HSA-74259 0.999690 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.999701 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 0.999720 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 0.999747 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.999782 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 0.999819 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.999819 0.000 0 0
ABC transporter disorders R-HSA-5619084 0.999831 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 0.999831 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 0.999836 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.999858 0.000 0 0
G alpha (q) signalling events R-HSA-416476 0.999859 0.000 0 0
O-linked glycosylation R-HSA-5173105 0.999868 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 0.999875 0.000 0 0
Mitochondrial translation R-HSA-5368287 0.999878 0.000 0 0
Hemostasis R-HSA-109582 0.999899 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 0.999908 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.999944 0.000 0 0
Sphingolipid metabolism R-HSA-428157 0.999952 0.000 0 0
Diseases of glycosylation R-HSA-3781865 0.999953 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.999970 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 0.999973 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 0.999973 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 0.999973 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.999976 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.999980 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.999990 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 0.999990 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 0.999991 0.000 0 0
G alpha (i) signalling events R-HSA-418594 0.999996 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 0.999997 0.000 0 0
Translation R-HSA-72766 0.999997 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.999998 0.000 0 0
Keratinization R-HSA-6805567 0.999998 0.000 0 0
Visual phototransduction R-HSA-2187338 0.999999 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 0.999999 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 0.999999 0.000 0 0
Arachidonate metabolism R-HSA-2142753 0.999999 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000 0.000 0 0
Immune System R-HSA-168256 1.000000 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000 0.000 0 0
Infectious disease R-HSA-5663205 1.000000 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000 0.000 0 0
Innate Immune System R-HSA-168249 1.000000 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000 0.000 0 0
Drug ADME R-HSA-9748784 1.000000 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.000000 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000 0.000 0 0
Disease R-HSA-1643685 1.000000 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000 0.000 0 0
Biological oxidations R-HSA-211859 1.000000 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000 -0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways