CAMK2A

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A4FU28 S140 Sugiyama CTAGE9 AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00273 S28 Sugiyama DFFA DFF1 DFF45 H13 GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O00488 S93 Sugiyama ZNF593 ZT86 STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O00488 Y97 Sugiyama ZNF593 ZT86 KTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVPPRRL
O00631 T5 SIGNOR|EPSD|PSP SLN ________________MGINtRELFLNFTIVLITVILMWLL
O14490 S356 SIGNOR DLGAP1 DAP1 GKAP EIPCRRMRSGsYIKAMGDEDsGDsDtsPKPsPKVAARREsY
O14713 T38 SIGNOR|iPTMNet|EPSD|PSP ITGB1BP1 ICAP1 EISTKSKsVDssLGGLsRsstVAsLDTDSTKssGQSNNNSD
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14980 S1055 Sugiyama XPO1 CRM1 LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15143 S310 Sugiyama ARPC1B ARC41 QSSQRGLTARERFQNLDKKAssEGGtAAGAGLDsLHKNsVs
O15143 S311 Sugiyama ARPC1B ARC41 SSQRGLTARERFQNLDKKAssEGGtAAGAGLDsLHKNsVsQ
O15273 S157 EPSD|PSP TCAP TKQLPPVVPVSKPGALRRSLsRSMsQEAQRG__________
O15273 S161 EPSD|PSP TCAP PPVVPVSKPGALRRSLsRSMsQEAQRG______________
O43164 S253 Sugiyama PJA2 KIAA0438 RNF131 LDsVPLVKssAGDTEFVHQNsQEIQRSSQDEMVSTKQQNNT
O43390 T137 Sugiyama HNRNPR HNRPR ESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O43399 S166 Sugiyama TPD52L2 tVGsAIsRKLGDMRNsAtFKsFEDRVGtIKSKVVGDRENGs
O43399 T163 Sugiyama TPD52L2 ALstVGsAIsRKLGDMRNsAtFKsFEDRVGtIKSKVVGDRE
O43707 T69 Sugiyama ACTN4 EKQQRKTFTAWCNsHLRKAGtQIENIDEDFRDGLKLMLLLE
O43823 S399 Sugiyama AKAP8 AKAP95 RTRDRAADRIQFACSVCKFRsFDDEEIQKHLQSKFHKETLR
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O60266 S1076 ELM ADCY3 KIAA0511 ARKPHYDIWGNTVNVASRMEsTGVMGNIQVVEETQVILREY
O60506 T134 Sugiyama SYNCRIP HNRPQ NSAP1 DSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O60664 S148 Sugiyama PLIN3 M6PRBP1 TIP47 KVsGAQEMVssAKDTVAtQLsEAVDATRGAVQSGVDKTKsV
O60749 S365 Sugiyama SNX2 TRG9 AKSAAMLGNsEDHTALSRALsQLAEVEEKIDQLHQEQAFAD
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841 S178 Sugiyama EIF5B IF2 KIAA0741 NKKWDGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRK
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841 S66 Sugiyama EIF5B IF2 KIAA0741 KEKKKQDFDEDDILKELEELsLEAQGIKADREtVAVKPTEN
O75469 T290 PSP NR1I2 PXR EDQIsLLKGAAFELCQLRFNtVFNAETGTWECGRLsYCLED
O75534 T761 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN
O75821 S189 Sugiyama EIF3G EIF3S4 CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O95071 S327 Sugiyama UBR5 EDD EDD1 HYD KIAA0896 LLRERESVLRLRERRWLDGAsFDNERGSTSKEGEPNLDKKN
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95180 S1198 PSP CACNA1H EAEDGRAAPGPRATPLRRAEsLDPRPLRPAALPPTKCRDRD
O95180 S2137 SIGNOR CACNA1H PHGPEASPVAGGERDLRRLYsVDAQGFLDKPGRADEQWRPS
O95218 S120 Sugiyama ZRANB2 ZIS ZNF265 tGYGGGFNERENVEyIEREEsDGEyDEFGRKKKKYRGKAVG
O95218 S188 Sugiyama ZRANB2 ZIS ZNF265 KLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRRSRSKSRS
O95425 S914 Sugiyama SVIL LRTKPPLDHNAsAtDYKFSssIENsDsPVRSILKSQAWQPL
O95425 S968 Sugiyama SVIL GETESKRALTGRDSGMEKyGsFEEAEASYPILNRAREGDSH
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95997 S31 SIGNOR|PSP PTTG1 EAP1 PTTG TUTR1 NGEPGTRVVAKDGLKLGsGPsIKALDGRSQVSTPRFGKTFD
O95997 S87 SIGNOR|PSP PTTG1 EAP1 PTTG TUTR1 VNRATEKSVKTKGPLKQKQPsFsAKKMTEKTVKAKSSVPAS
O95997 S89 SIGNOR|PSP PTTG1 EAP1 PTTG TUTR1 RATEKSVKTKGPLKQKQPsFsAKKMTEKTVKAKSSVPASDD
O95997 T66 SIGNOR|PSP PTTG1 EAP1 PTTG TUTR1 FGKTFDAPPALPKAtRKALGtVNRATEKSVKTKGPLKQKQP
O96013 S41 Sugiyama PAK4 KIAA1142 VHTGFDQHEQKFTGLPRQWQsLIEESARRPKPLVDPACITS
P00533 S1064 SIGNOR|iPTMNet EGFR ERBB ERBB1 HER1 NstVACIDRNGLQsCPIKEDsFLQRyssDPtGALtEDsIDD
P00533 S1070 SIGNOR|ELM|iPTMNet|EPSD EGFR ERBB ERBB1 HER1 IDRNGLQsCPIKEDsFLQRyssDPtGALtEDsIDDtFLPVP
P00533 S1071 SIGNOR|ELM|iPTMNet|EPSD EGFR ERBB ERBB1 HER1 DRNGLQsCPIKEDsFLQRyssDPtGALtEDsIDDtFLPVPE
P00533 S1081 SIGNOR|ELM|iPTMNet|EPSD EGFR ERBB ERBB1 HER1 KEDsFLQRyssDPtGALtEDsIDDtFLPVPEyINQsVPKRP
P00533 S1120 SIGNOR|iPTMNet EGFR ERBB ERBB1 HER1 RPAGsVQNPVyHNQPLNPAPsRDPHyQDPHstAVGNPEyLN
P00533 S1166 SIGNOR|ELM|iPTMNet|EPSD EGFR ERBB ERBB1 HER1 CVNSTFDsPAHWAQKGsHQIsLDNPDyQQDFFPKEAKPNGI
P00533 S768 SIGNOR|ELM|iPTMNet|EPSD EGFR ERBB ERBB1 HER1 REATSPKANKEILDEAyVMAsVDNPHVCRLLGICLTSTVQL
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075 T49 Sugiyama ALDOA ALDA GILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtADDR
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S210 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04626 T1172 ELM|EPSD ERBB2 HER2 MLN19 NEU NGL PREGPLPAARPAGAtLERPKtLSPGKNGVVKDVFAFGGAVE
P04792 S15 Sugiyama HSPB1 HSP27 HSP28 ______MTERRVPFsLLRGPsWDPFRDWyPHsRLFDQAFGL
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S86 Sugiyama HSPB1 HSP27 HSP28 PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP
P05198 S219 Sugiyama EIF2S1 EIF2A CYGYEGIDAVKEALRAGLNCsTENMPIKINLIAPPRYVMTT
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05423 S250 Sugiyama POLR3D BN51 BN51T AKMKAPPKAARKTPGLPKDVsVAELLRELSLTKEEELLFLQ
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05556 T788 EPSD|PSP ITGB1 FNRB MDF2 MSK12 KEKMNAKWDtGENPIyKsAVttVVNPKyEGK__________
P05556 T789 EPSD|PSP ITGB1 FNRB MDF2 MSK12 EKMNAKWDtGENPIyKsAVttVVNPKyEGK___________
P05783 S53 SIGNOR|ELM|iPTMNet KRT18 CYK18 PIG46 AsVyAGAGGsGsRIsVsRstsFRGGMGsGGLAtGIAGGLAG
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P07101 S19 SIGNOR|ELM|EPSD|PSP TH TYH __MPTPDATTPQAKGFRRAVsELDAKQAEAIMVRGQGAPGP
P07101 S71 ELM|EPSD|PSP TH TYH APAASYTPTPRsPRFIGRRQsLIEDARKEREAAVAAAAAAV
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07237 S427 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07339 S37 Sugiyama CTSD CPSD PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07737 T65 Sugiyama PFN1 PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737 Y60 Sugiyama PFN1 FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07814 S747 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 ETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVREL
P07900 S391 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900 S399 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900 S468 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA GIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKENQ
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 T305 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P07900 T467 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKEN
P08238 S383 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238 S391 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08670 S83 ELM|EPSD|PSP VIM tRssAVRLRssVPGVRLLQDsVDFsLADAINTEFKNTRTNE
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09234 S48 Sugiyama SNRPC RKHKENVKDYYQKWMEEQAQsLIDKTTAAFQQGKIPPTPFS
P09382 S63 Sugiyama LGALS1 CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09417 S223 ELM QDPR DHPR SDR33C1 TPLEFLVETFHDWITGKNRPsSGsLIQVVTTEGRTELTPAY
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09917 S272 SIGNOR|ELM|EPSD|PSP ALOX5 LOG5 LPEKLPVtTEMVECSLERQLsLEQEVQQGNIFIVDFELLDG
P0CG41 S140 Sugiyama CTAGE8 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P10412 S89 Sugiyama H1-4 H1F4 HIST1H1E AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P10412 T92 Sugiyama H1-4 H1F4 HIST1H1E DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P10636 S552 SIGNOR MAPT MAPTL MTBT1 TAU LPtPPTREPKKVAVVRtPPKsPssAKSRLQTAPVPMPDLKN
P10636 S579 SIGNOR MAPT MAPTL MTBT1 TAU RLQTAPVPMPDLKNVKsKIGstENLKHQPGGGKVQIINKKL
P10636 T548 SIGNOR MAPT MAPTL MTBT1 TAU RtPsLPtPPTREPKKVAVVRtPPKsPssAKSRLQTAPVPMP
P11532 S3623 Sugiyama DMD EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P11717 S1378 Sugiyama IGF2R MPRI QYACPPFDLTECSFKDGAGNsFDLsSLSRYSDNWEAITGTG
P11831 S103 SIGNOR|iPTMNet|EPSD|PSP SRF sEsGEEEELGAERRGLKRsLsEMEIGMVVGGPEASAAATGG
P11831 T160 GPS6|SIGNOR|iPTMNet SRF TRGRVKIKMEFIDNKLRRYttFsKRKTGIMKKAYELSTLTG
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12268 S416 Sugiyama IMPDH2 IMPD2 APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P12956 S477 Sugiyama XRCC6 G22P1 EQVGKMKAIVEKLRFtYRsDsFENPVLQQHFRNLEALALDL
P13073 S89 Sugiyama COX4I1 COX4 SWssLsMDEKVELYRIKFKEsFAEMNRGSNEWKTVVGGAMF
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S584 Sugiyama EEF2 EF2 DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13639 S732 Sugiyama EEF2 EF2 DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13639 T735 Sugiyama EEF2 EF2 HRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCPEQV
P13639 Y730 Sugiyama EEF2 EF2 HADAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQ
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P14136 S13 SIGNOR|ELM|iPTMNet GFAP ________MERRRItsAARRsYVssGEMMVGGLAPGRRLGP
P14136 S17 SIGNOR|ELM|iPTMNet GFAP ____MERRRItsAARRsYVssGEMMVGGLAPGRRLGPGTRL
P14136 S38 SIGNOR|ELM|iPTMNet GFAP GEMMVGGLAPGRRLGPGTRLsLARMPPPLPTRVDFSLAGAL
P14136 S393 SIGNOR|iPTMNet GFAP EENRITIPVQTFSNLQIRETsLDTKSVSEGHLKRNIVVKTV
P14921 S251 SIGNOR|ELM|iPTMNet|EPSD|PSP ETS1 EWSR2 VTPDNMCMGRTSRGKLGGQDsFEsIEsYDSCDRLtQsWssQ
P14921 S257 SIGNOR|ELM|iPTMNet|EPSD|PSP ETS1 EWSR2 CMGRTSRGKLGGQDsFEsIEsYDSCDRLtQsWssQssFNsL
P14921 S282 SIGNOR|ELM|iPTMNet|EPSD|PSP ETS1 EWSR2 DRLtQsWssQssFNsLQRVPsyDsFDsEDYPAALPNHKPKG
P14921 S285 SIGNOR|ELM|iPTMNet|EPSD|PSP ETS1 EWSR2 tQsWssQssFNsLQRVPsyDsFDsEDYPAALPNHKPKGTFK
P15036 S246 SIGNOR|EPSD|PSP ETS2 TPSVLSSEQEFQMFPKSRLSsVsVTYCSVsQDFPGSNLNLL
P15036 S310 SIGNOR|EPSD|PSP ETS2 DSLLQSWNSQSSLLDVQRVPsFEsFEDDCsQSLCLNKPTMS
P15036 S313 SIGNOR|EPSD|PSP ETS2 LQSWNSQSSLLDVQRVPsFEsFEDDCsQSLCLNKPTMSFKD
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S536 Sugiyama EZR VIL2 KRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNE
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15336 S62 Sugiyama ATF2 CREB2 CREBP1 LAVHKHKHEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEV
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15880 T285 Sugiyama RPS2 RPS4 PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P16070 S706 SIGNOR|EPSD|PSP CD44 LHR MDU2 MDU3 MIC4 sGNGAVEDRKPsGLNGEAsKsQEMVHLVNKEssEtPDQFMt
P16070 S71 Sugiyama CD44 LHR MDU2 MDU3 MIC4 DLCKAFNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRI
P16220 S142 SIGNOR|ELM CREB1 KILNDLssDAPGVPRIEEEKsEEETSAPAITTVTVPTPIYQ
P16401 S92 Sugiyama H1-5 H1F5 HIST1H1B GGYDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16401 T95 Sugiyama H1-5 H1F5 HIST1H1B DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16402 S90 Sugiyama H1-3 H1F3 HIST1H1D AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16402 T93 Sugiyama H1-3 H1F3 HIST1H1D DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16403 S89 Sugiyama H1-2 H1F2 HIST1H1C AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16403 T92 Sugiyama H1-2 H1F2 HIST1H1C DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16615 S38 SIGNOR|ELM|iPTMNet ATP2A2 ATP2B VNESTGLSLEQVKKLKERWGsNELPAEEGKTLLELVIEQFE
P16949 S16 SIGNOR|EPSD|PSP STMN1 C1orf215 LAP18 OP18 _____MAssDIQVKELEKRAsGQAFELILsPRsKEsVPEFP
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17676 S325 SIGNOR|ELM|iPTMNet CEBPB TCF5 PP9092 ELTAENERLQKKVEQLSRELsTLRNLFKQLPEPLLAssGHC
P17987 S544 Sugiyama TCP1 CCT1 CCTA ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S328 Sugiyama NCL NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338 S580 Sugiyama NCL PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P19338 S619 Sugiyama NCL RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P20042 S67 Sugiyama EIF2S2 EIF2B EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK
P20941 S54 SIGNOR|iPTMNet PDC LESQDSDSIPPSKKEILRQMsSPQSRNGKDSKERVSRKMsI
P20941 S73 SIGNOR|iPTMNet PDC MsSPQSRNGKDSKERVSRKMsIQEYELIHKEKEDENCLRKY
P21333 S2523 ELM|EPSD|PSP FLNA FLN FLN1 GPYHIGGsPFKAKVTGPRLVsNHsLHEtsSVFVDsLtKATC
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P22626 T140 Sugiyama HNRNPA2B1 HNRPA2B1 KEDTEEHHLRDyFEEYGKIDtIEIItDRQsGKKRGFGFVtF
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588 S131 Sugiyama EIF4B SIKEFFRGLNIsAVRLPREPsNPERLKGFGyAEFEDLDSLL
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588 S597 Sugiyama EIF4B KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______
P23588 T205 Sugiyama EIF4B GRDRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYR
P23677 T311 SIGNOR|ELM|EPSD|PSP ITPKA KMLAVDPEAPTEEEHAQRAVtKPRYMQWREGISSSTTLGFR
P23921 S780 Sugiyama RRM1 RR1 KEKVSKEEEEKERNtAAMVCsLENRDECLMCGS________
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P24588 S92 EPSD|PSP AKAP5 AKAP79 PEPTRGAWAsLKRLVtRRKRsESSKQQKPLEGEMQPAINAE
P24588 T87 EPSD|PSP AKAP5 AKAP79 GASDQPEPTRGAWAsLKRLVtRRKRsESSKQQKPLEGEMQP
P25054 S1389 Sugiyama APC DP2.5 PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25705 S65 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM KtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARVH
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 S97 Sugiyama RPL13 BBC1 OK/SW-cl.46 sLEELRVAGIHKKVARTIGIsVDPRRRNKstEsLQANVQRL
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26639 T700 Sugiyama TARS1 TARS EKISGTVNIRTRDNKVHGERtIsEtIERLQQLKEFRSKQAE
P26639 T704 Sugiyama TARS1 TARS GTVNIRTRDNKVHGERtIsEtIERLQQLKEFRSKQAEEEF_
P26641 S286 Sugiyama EEF1G EF1G PRO1608 CEQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVA
P26678 T17 EPSD|PSP PLN PLB ____MEKVQYLTRSAIRRAstIEMPQQARQKLQNLFINFCL
P27797 S53 Sugiyama CALR CRTC WtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDAR
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P28329 T574 SIGNOR CHAT YESAsIRRFQEGRVDNIRSAtPEALAFVRAVTDHKAAVPAs
P28340 S1064 Sugiyama POLD1 POLD LNALEERFSRLWTQCQRCQGsLHEDVICTSRDCPIFyMRKK
P29475 S852 GPS6|SIGNOR|ELM|iPTMNet|EPSD NOS1 EMRHPNSVQEERKSYKVRFNsVSSYSDsQKSSGDGPDLRDN
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692 S86 Sugiyama EEF1D EF1D GPGAssGtsGDHGELVVRIAsLEVENQsLRGVVQELQQAIs
P30040 T62 Sugiyama ERP29 C12orf8 ERP28 DtVtFyKVIPKSKFVLVKFDtQyPyGEKQDEFKRLAENSAS
P30043 T190 Sugiyama BLVRB FLR SCAN RGPSRVISKHDLGHFMLRCLttDEyDGHstyPsHQyQ____
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30533 S247 Sugiyama LRPAP1 A2MRAP KLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQSA
P30533 Y246 Sugiyama LRPAP1 A2MRAP EKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQS
P30626 S111 Sugiyama SRI GFNEFKELWAVLNGWRQHFIsFDTDRSGTVDPQELQKALtt
P31327 S537 Sugiyama CPS1 GVELFKRGVLKEYGVKVLGtsVEsIMATEDRQLFSDKLNEI
P31645 S13 EPSD|PSP SLC6A4 HTT SERT ________METTPLNSQKQLsACEDGEDCQENGVLQKVVPT
P31943 S23 Sugiyama HNRNPH1 HNRPH HNRPH1 LGTEGGEGFVVKVRGLPWsCsADEVQRFFSDCKIQNGAQGI
P32119 S112 Sugiyama PRDX2 NKEFB TDPX1 KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33527 S915 Sugiyama ABCC1 MRP MRP1 QMENGMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQ
P35222 S552 EPSD|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 AIPRLVQLLVRAHQDtQRRtsMGGtQQQFVEGVRMEEIVEG
P35222 T332 EPSD|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 KLIILASGGPQALVNIMRTytyEKLLWTTSRVLKVLSVCSs
P35222 T472 EPSD|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 LRAGDREDITEPAICALRHLtSRHQEAEMAQNAVRLHyGLP
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269 T156 Sugiyama GTF2F1 RAP74 EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35270 S213 EPSD|PSP SPR VLNYAPGPLDTDMQQLARETsVDPDMRKGLQELKAKGKLVD
P35367 S396 ELM|EPSD|PSP HRH1 LRsGsNtGLDYIKFTWKRLRsHsRQYVSGLHMNRERKAAKQ
P35367 S398 SIGNOR|ELM|EPSD|PSP HRH1 sGsNtGLDYIKFTWKRLRsHsRQYVSGLHMNRERKAAKQLG
P35367 T140 SIGNOR|ELM|EPSD|PSP HRH1 ILCIDRYRSVQQPLRYLKYRtKtRASATILGAWFLSFLWVI
P35367 T142 ELM|EPSD|PSP HRH1 CIDRYRSVQQPLRYLKYRtKtRASATILGAWFLSFLWVIPI
P35372 S268 SIGNOR|EPSD|PSP OPRM1 MOR1 LIITVCYGLMILRLKSVRMLsGsKEKDRNLRRITRMVLVVV
P35372 S270 SIGNOR OPRM1 MOR1 ITVCYGLMILRLKSVRMLsGsKEKDRNLRRITRMVLVVVAV
P35372 T372 SIGNOR OPRM1 MOR1 FCIPtssNIEQQNsTRIRQNtRDHPstANtVDRTNHQLENL
P35637 S340 Sugiyama FUS TLS PMINLyTDRETGKLKGEAtVsFDDPPsAKAAIDWFDGKEFs
P35637 T338 Sugiyama FUS TLS GQPMINLyTDRETGKLKGEAtVsFDDPPsAKAAIDWFDGKE
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578 S55 Sugiyama RPL4 RPL1 DIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVAR
P36578 S63 Sugiyama RPL4 RPL1 NLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGG
P36578 S87 Sugiyama RPL4 RPL1 WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578 T84 Sugiyama RPL4 RPL1 AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37840 S129 EPSD|PSP SNCA NACP PARK1 QEGILEDMPVDPDNEAyEMPsEEGyQDyEPEA_________
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T94 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P40189 S782 PSP IL6ST VVHSGyRHQVPSVQVFSRsEstQPLLDSEERPEDLQLVDHV
P40429 T153 Sugiyama RPL13A RKFAYLGRLAHEVGWKyQAVtAtLEEKRKEKAKIHYRKKKQ
P40429 T155 Sugiyama RPL13A FAYLGRLAHEVGWKyQAVtAtLEEKRKEKAKIHYRKKKQLM
P41091 T464 Sugiyama EIF2S3 EIF2G SRRVEKHWRLIGWGQIRRGVtIKPtVDDD____________
P41091 T468 Sugiyama EIF2S3 EIF2G EKHWRLIGWGQIRRGVtIKPtVDDD________________
P41134 S36 SIGNOR|EPSD|PSP ID1 BHLHB24 ID SCALKAGKTASGAGEVVRCLsEQSVAISRCAGGAGARLPAL
P41236 S24 Sugiyama PPP1R2 IPP2 STAsHRPIKGILKNKtsttssMVAsAEQPRGNVDEELSKKs
P42261 S567 EPSD|PSP GRIA1 GLUA1 GLUH1 GLUR1 YIGVSVVLFLVSRFSPYEWHsEEFEEGRDQTTSDQSNEFGI
P42261 S849 ELM GRIA1 GLUA1 GLUH1 GLUR1 CYKsRsEsKRMKGFCLIPQQsINEAIRTStLPRNsGAGASS
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P42766 T59 Sugiyama RPL35 GAASKLsKIRVVRKSIARVLtVINQtQKENLRKFYKGKKyK
P42766 T64 Sugiyama RPL35 LsKIRVVRKSIARVLtVINQtQKENLRKFYKGKKyKPLDLR
P43003 T26 EPSD|PSP SLC1A3 EAAT1 GLAST GLAST1 GEEPKMGGRMERFQQGVRKRtLLAKKKVQNItKEDVKSYLF
P43003 T37 EPSD|PSP SLC1A3 EAAT1 GLAST GLAST1 RFQQGVRKRtLLAKKKVQNItKEDVKSYLFRNAFVLLTVTA
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43034 S157 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA yEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADMTIKLW
P43034 S399 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA HEHFVTSLDFHKTAPYVVTGsVDQTVKVWECR_________
P43034 T150 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA ATIKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSA
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490 S472 Sugiyama NAMPT PBEF PBEF1 EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46013 S1098 Sugiyama MKI67 PAARVTGMKKWPRtPKEEAQsLEDLAGFKELFQtPGPsEEs
P46013 T1764 Sugiyama MKI67 LVDtPtssKPQPKRSLRKADtEEEFLAFRKQTPSAGKAMHt
P46527 S10 EPSD|PSP CDKN1B KIP1 p27 ___________MSNVRVSNGsPsLERMDARQAEHPKPSACR
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46937 T110 Sugiyama YAP1 YAP65 KLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssPA
P46937 T114 Sugiyama YAP1 YAP65 sFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQL
P47712 S515 ELM|EPSD PLA2G4A CPLA2 PLA2G4 GLNLNTSYPLsPLSDFATQDsFDDDELDAAVADPDEFERIy
P48058 S862 SIGNOR GRIA4 GluA4 GLUR4 AEAKRMKLtFSEAIRNKARLsITGSVGENGRVLTPDCPKAV
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51790 S109 SIGNOR|EPSD|PSP CLCN3 HTIDWVREKCKDRERHRRINsKKKESAWEMTKSLYDAWSGW
P52272 S528 Sugiyama HNRNPM HNRPM NAGR1 IERMGsGVERMGPAIERMGLsMERMVPAGMGAGLERMGPVM
P52272 S618 Sugiyama HNRNPM HNRPM NAGR1 PALGAGIERMGLAMGGGGGAsFDRAIEMERGNFGGsFAGsF
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52943 S115 Sugiyama CRIP2 CRP2 AARAEERKAsGPPKGPsRAssVttFtGEPNtCPRCSKKVYF
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999 S12 Sugiyama SUB1 PC4 RPO2TC1 _________MPKSKELVsssssGsDsDsEVDKKLKRKKQVA
P53999 S56 Sugiyama SUB1 PC4 RPO2TC1 PVKKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRD
P55042 S273 EPSD|PSP RRAD RAD LRRDsKEANARRQAGTRRREsLGKKAKRFLGRIVARNsRKM
P55055 S426 EPSD NR1H2 LXRB NER UNR TRIKRPQDQLRFPRMLMKLVsLRTLsSVHSEQVFALRLQDK
P55081 S132 Sugiyama MFAP1 VVGEsDsEVEGDAWRMEREDssEEEEEEIDDEEIERRRGMM
P55081 S133 Sugiyama MFAP1 VGEsDsEVEGDAWRMEREDssEEEEEEIDDEEIERRRGMMR
P55081 S94 Sugiyama MFAP1 EEQEEDsssDPRLRRLQNRIsEDVEERLARHRKIVEPEVVG
P55769 S122 Sugiyama SNU13 NHP2L1 CSVTIKEGSQLKQQIQsIQQsIERLLV______________
P60174 S198 Sugiyama TPI1 TPI TPQQAQEVHEKLRGWLKsNVsDAVAQstRIIyGGsVtGAtC
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61916 S29 Sugiyama NPC2 HE1 LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P61978 S420 Sugiyama HNRNPK HNRPK GsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITItGt
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 T229 Sugiyama YWHAE LsEEsyKDstLIMQLLRDNLtLWtsDMQGDGEEQNKEALQD
P62258 T232 Sugiyama YWHAE EsyKDstLIMQLLRDNLtLWtsDMQGDGEEQNKEALQDVED
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62266 S45 Sugiyama RPS23 KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T119 Sugiyama RPL31 PNKLytLVtyVPVttFKNLQtVNVDEN______________
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S138 Sugiyama RPL8 EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62937 T157 Sugiyama PPIA CYPA NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62979 S123 Sugiyama RPS27A UBA80 UBCEP1 LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T226 Sugiyama YWHAZ LsEEsyKDstLIMQLLRDNLtLWtsDtQGDEAEAGEGGEN_
P63167 S14 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 _______MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNI
P63167 S21 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH
P63220 S65 Sugiyama RPS21 RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 T126 Sugiyama YBX1 NSEP1 YB1 GEtVEFDVVEGEKGAEAANVtGPGGVPVQGsKYAADRNHYR
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P78352 S73 PSP DLG4 PSD95 QVNGTEGEMEYEEITLERGNsGLGFSIAGGTDNPHIGDDPS
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 S13 Sugiyama RPL19 ________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEIA
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q00613 S230 SIGNOR|ELM|iPTMNet|EPSD|PSP HSF1 HSTF1 PLMLNDsGsAHSMPKYSRQFsLEHVHGSGPYSAPSPAYSSS
Q00839 S59 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 QAALDDEEAGGRPAMEPGNGsLDLGGDsAGRSGAGLEQEAA
Q00975 S2120 SIGNOR CACNA1B CACH5 CACNL1A5 RERERRQERGRSQERRQPSSsSSEKQRFYSCDRFGGREPPK
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q01650 S31 Sugiyama SLC7A5 CD98LC LAT1 MPE16 LAAPAAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNIT
Q01970 S537 ELM|EPSD|PSP PLCB3 PGLSNGEEVGLEKPSLEPQKsLGDEGLNRGPyVLGPADRED
Q02539 S92 Sugiyama H1-1 H1F1 HIST1H1A AGyDVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNK
Q02539 T95 Sugiyama H1-1 H1F1 HIST1H1A DVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNKKAS
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q02952 S648 Sugiyama AKAP12 AKAP250 EsDKEDELDKVKsAtLsstEstAsEMQEEMKGsVEEPKPEE
Q04637 S1238 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q04760 T107 SIGNOR|EPSD|PSP GLO1 EKIAWALSRKATLELTHNWGtEDDEtQsyHNGNsDPRGFGH
Q05397 S677 Sugiyama PTK2 FAK FAK1 KCWAYDPSRRPRFTELKAQLsTILEEEKAQQEERMRMEsRR
Q05397 S843 SIGNOR PTK2 FAK FAK1 QRWLEKEERFLKPDVRLsRGsIDREDGsLQGPIGNQHIyQP
Q05469 S855 SIGNOR LIPE SGRKSQKMSEPIAEPMRRsVsEAALAQPQGPLGTDSLKNLT
Q05682 S643 SIGNOR CALD1 CAD CDM PEDGLsDDKKPFKCFTPKGSsLKIEERAEFLNKsVQKsSGV
Q05682 S656 SIGNOR CALD1 CAD CDM CFTPKGSsLKIEERAEFLNKsVQKsSGVKSTHQAAIVSKID
Q06210 S261 SIGNOR|EPSD|PSP|Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06830 S152 Sugiyama PRDX1 PAGA PAGB TDPX2 IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q07157 S1051 Sugiyama TJP1 ZO1 PDKEPNLTyEPQLPYVEKQAsRDLEQPtyRyEsssytDQFs
Q07666 S20 Sugiyama KHDRBS1 SAM68 _MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q08945 S657 Sugiyama SSRP1 FACT80 MEKKSTPSRGsSSKSsSRQLsEsFKSKEFVssDEsssGENK
Q08AD1 S464 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q12830 S1310 Sugiyama BPTF FAC1 FALZ DRVLDDVsIRsPEtKCPKQNsIENDIEEKVSDLASRGQEPS
Q12879 S1291 iPTMNet GRIN2A NMDAR2A WAQNNALQLQKNKLRISRQHsyDNIVDKPRELDLSRPSRSI
Q12879 S1459 PSP GRIN2A NMDAR2A YSTPRVLNSCSNRRVYKKMPsIESDV_______________
Q12959 S232 SIGNOR|ELM|iPTMNet DLG1 YVNGTDADYEYEEITLERGNsGLGFSIAGGTDNPHIGDDSS
Q13206 S831 Sugiyama DDX10 DMENKISDTKKKQGMKKRsNsEVEDVGPTsHNRKKARWDTL
Q13224 S1303 SIGNOR|iPTMNet|EPSD|PSP GRIN2B NMDAR2B QSPTNSKAQKKNRNKLRRQHsYDTFVDLQKEEAALAPRSVs
Q13224 S383 iPTMNet GRIN2B NMDAR2B VIILLNKERKWERVGKWKDKsLQMKYYVWPRMCPETEEQED
Q13263 S473 Sugiyama TRIM28 KAP1 RNF96 TIF1B sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13283 S250 Sugiyama G3BP1 G3BP sssPAPADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGI
Q13283 S253 Sugiyama G3BP1 G3BP PAPADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGIPPH
Q13442 S19 Sugiyama PDAP1 HASPP28 __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13554 S26 Sugiyama CAMK2B CAM2 CAMK2 CAMKB TCTRFTDEYQLYEDIGKGAFsVVRRCVKLCTGHEYAAKIIN
Q13554 T306 Sugiyama CAMK2B CAM2 CAMK2 CAMKB EtVECLKKFNARRKLKGAILttMLAtRNFSVGRQTtAPAtM
Q13554 T307 Sugiyama CAMK2B CAM2 CAMK2 CAMKB tVECLKKFNARRKLKGAILttMLAtRNFSVGRQTtAPAtMS
Q13555 S26 Sugiyama CAMK2G CAMK CAMK-II CAMKG TCTRFTDDYQLFEELGKGAFsVVRRCVKKTstQEYAAKIIN
Q13557 S26 Sugiyama CAMK2D CAMKD TCTRFTDEyQLFEELGKGAFsVVRRCMKIPTGQEYAAKIIN
Q13557 T306 Sugiyama CAMK2D CAMKD EtVDCLKKFNARRKLKGAILttMLAtRNFsAAKsLLKKPDG
Q13557 T307 Sugiyama CAMK2D CAMKD tVDCLKKFNARRKLKGAILttMLAtRNFsAAKsLLKKPDGV
Q13596 S368 Sugiyama SNX1 AKSLAMLGSSEDNTALSRALsQLAEVEEKIEQLHQEQANND
Q13698 S1575 SIGNOR CACNA1S CACH1 CACN1 CACNL1A3 IQAGLRTIEEEAAPEICRtVsGDLAAEEELERAMVEAAMEE
Q14126 S551 Sugiyama DSG2 CDHF5 FSVIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFL
Q14151 S613 Sugiyama SAFB2 KIAA0138 ERSSKSQDRKSESKEKRDILsFDKIKEQRERERQRQREREI
Q14152 S492 Sugiyama EIF3A EIF3S10 KIAA0139 VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14157 T239 Sugiyama UBAP2L KIAA0144 NICE4 GNTWNNTGHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIF
Q14157 T241 Sugiyama UBAP2L KIAA0144 NICE4 TWNNTGHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIFtA
Q14247 S282 Sugiyama CTTN EMS1 QKDyKTGFGGKFGVQsERQDsAAVGFDyKEKLAKHEsQQDy
Q14444 S307 Sugiyama CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 SEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEVVNSL
Q14457 S90 EPSD|PSP BECN1 GT197 IETPRQDGVSRRFIPPARMMsTEsANsFTLIGEASDGGtME
Q14457 S93 PSP BECN1 GT197 PRQDGVSRRFIPPARMMsTEsANsFTLIGEASDGGtMENLS
Q14457 S96 PSP BECN1 GT197 DGVSRRFIPPARMMsTEsANsFTLIGEASDGGtMENLSRRL
Q14498 S337 Sugiyama RBM39 HCC1 RNPC2 AGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGRL
Q14524 S1003 PSP SCN5A GLLRQRPQKPAALAAQGQLPsCIATPYSPPPPETEKVPPTR
Q14524 S11 PSP SCN5A __________MANFLLPRGTssFRRFtREsLAAIEKRMAEK
Q14524 S12 PSP SCN5A _________MANFLLPRGTssFRRFtREsLAAIEKRMAEKQ
Q14524 S1503 PSP SCN5A QDIFMTEEQKKyyNAMKKLGsKKPQKPIPRPLNKYQGFIFD
Q14524 S1865 PSP SCN5A GDRIHCMDILFAFTKRVLGEsGEMDALKIQMEEKFMAANPs
Q14524 S1885 PSP SCN5A sGEMDALKIQMEEKFMAANPsKISYEPITTTLRRKHEEVSA
Q14524 S1920 PSP SCN5A HEEVSAMVIQRAFRRHLLQRsLKHAsFLFRQQAGsGLsEED
Q14524 S1925 PSP SCN5A AMVIQRAFRRHLLQRsLKHAsFLFRQQAGsGLsEEDAPERE
Q14524 S1934 PSP SCN5A RHLLQRsLKHAsFLFRQQAGsGLsEEDAPEREGLIAYVMSE
Q14524 S1937 PSP SCN5A LQRsLKHAsFLFRQQAGsGLsEEDAPEREGLIAYVMSENFS
Q14524 S1998 PSP SCN5A DSVTRATsDNLQVRGSDYSHsEDLADFPPsPDRDRESIV__
Q14524 S20 PSP SCN5A _MANFLLPRGTssFRRFtREsLAAIEKRMAEKQARGsTTLQ
Q14524 S2007 PSP SCN5A NLQVRGSDYSHsEDLADFPPsPDRDRESIV___________
Q14524 S42 PSP SCN5A AAIEKRMAEKQARGsTTLQEsREGLPEEEAPRPQLDLQAsK
Q14524 S457 PSP SCN5A AMEMLKKEHEALTIRGVDtVsRssLEMsPLAPVNsHERRSK
Q14524 S460 PSP SCN5A MLKKEHEALTIRGVDtVsRssLEMsPLAPVNsHERRSKRRK
Q14524 S464 PSP SCN5A EHEALTIRGVDtVsRssLEMsPLAPVNsHERRSKRRKRMss
Q14524 S471 PSP SCN5A RGVDtVsRssLEMsPLAPVNsHERRSKRRKRMssGtEECGE
Q14524 S483 PSP SCN5A MsPLAPVNsHERRSKRRKRMssGtEECGEDRLPKsDsEDGP
Q14524 S484 PSP SCN5A sPLAPVNsHERRSKRRKRMssGtEECGEDRLPKsDsEDGPR
Q14524 S497 PSP SCN5A KRRKRMssGtEECGEDRLPKsDsEDGPRAMNHLsLTRGLsR
Q14524 S499 PSP SCN5A RKRMssGtEECGEDRLPKsDsEDGPRAMNHLsLTRGLsRTS
Q14524 S510 PSP SCN5A GEDRLPKsDsEDGPRAMNHLsLTRGLsRTSMKPRssRGsIF
Q14524 S516 SIGNOR|PSP SCN5A KsDsEDGPRAMNHLsLTRGLsRTSMKPRssRGsIFTFRRRD
Q14524 S528 PSP SCN5A HLsLTRGLsRTSMKPRssRGsIFTFRRRDLGsEADFADDEN
Q14524 S539 PSP SCN5A SMKPRssRGsIFTFRRRDLGsEADFADDENSTAGESESHHT
Q14524 S571 SIGNOR|PSP SCN5A AGESESHHTSLLVPWPLRRtsAQGQPsPGTSAPGHALHGKK
Q14524 S577 PSP SCN5A HHTSLLVPWPLRRtsAQGQPsPGTSAPGHALHGKKNStVDC
Q14524 S61 PSP SCN5A EsREGLPEEEAPRPQLDLQAsKKLPDLYGNPPQELIGEPLE
Q14524 S664 PSP SCN5A TSQAPCVDGFEEPGARQRALsAVsVLtsALEELEESRHKCP
Q14524 S667 PSP SCN5A APCVDGFEEPGARQRALsAVsVLtsALEELEESRHKCPPCW
Q14524 T17 PSP SCN5A ____MANFLLPRGTssFRRFtREsLAAIEKRMAEKQARGsT
Q14524 T455 PSP SCN5A QEAMEMLKKEHEALTIRGVDtVsRssLEMsPLAPVNsHERR
Q14524 T570 PSP SCN5A TAGESESHHTSLLVPWPLRRtsAQGQPsPGTSAPGHALHGK
Q14524 T594 SIGNOR SCN5A GQPsPGTSAPGHALHGKKNStVDCNGVVSLLGAGDPEATSP
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14654 T180 EPSD|PSP KCNJ11 NAIMLGCIFMKTAQAHRRAEtLIFSKHAVIALRHGRLCFML
Q14654 T224 EPSD|PSP KCNJ11 DLRKSMIISATIHMQVVRKTtSPEGEVVPLHQVDIPMENGV
Q14674 S1501 EPSD|PSP ESPL1 ESP1 KIAA0165 GPEIMRTIPEEELTDNWRKMsFEILRGsDGEDsASGGKTPA
Q14677 S163 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 DRLREERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSK
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14684 S422 Sugiyama RRP1B KIAA0179 KKKKKHHLQPENPGPGGAAPsLEQNRGREPEASGLKALKAR
Q14738 S598 Sugiyama PPP2R5D DVyTIKALEAHKRAEEFLTAsQEAL________________
Q14847 S146 Sugiyama LASP1 MLN50 FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q14847 S99 Sugiyama LASP1 MLN50 ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14966 S1228 Sugiyama ZNF638 NP220 ZFML DLEKKGAEIINPKTALLPSDsVFAEERNLKGILEEsPsEAE
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15121 S116 SIGNOR|ELM PEA15 DtKLtRIPsAKKYKDIIRQPsEEEIIKLAPPPKKA______
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15293 S69 Sugiyama RCN1 RCN PPEDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVD
Q15398 T54 Sugiyama DLGAP5 DLG7 KIAA0008 NRHKEYERNRHFGLKDVNIPtLEGRILVELDETsQGLVPEK
Q15459 S690 Sugiyama SF3A1 SAP114 VHPPPPMEDEPTSKKLKTEDsLMPEEEFLRRNKGPVSIKVQ
Q15796 S110 SIGNOR|iPTMNet|EPSD|PSP SMAD2 MADH2 MADR2 PNTIDQWDTTGLYSFSEQTRsLDGRLQVSHRKGLPHVIyCR
Q15796 S240 SIGNOR|iPTMNet|EPSD|PSP SMAD2 MADH2 MADR2 tPPPGYISEDGETSDQQLNQsMDtGsPAELsPTTLsPVNHs
Q15796 S260 SIGNOR|iPTMNet|EPSD|PSP SMAD2 MADH2 MADR2 sMDtGsPAELsPTTLsPVNHsLDLQPVTYSEPAFWCSIAYY
Q15906 T137 ELM VPS72 TCFL1 YL1 LLPLELQDDGsDsRKsMRQStAEHTRQTFLRVQERQGQSRR
Q15906 T168 ELM VPS72 TCFL1 YL1 VQERQGQSRRRKGPHCERPLtQEELLREAKITEELNLRSLE
Q15906 T86 ELM VPS72 TCFL1 YL1 GDEPSsDGEAEEPRRKRRVVtKAYKEPLKSLRPRKVNTPAG
Q16204 S323 Sugiyama CCDC6 D10S170 TST1 RLQRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQ
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16626 S163 Sugiyama MEA1 MEA RTMAGVSLPAPGVPAWAREIsDAQWEDVVQKALQARQAsPA
Q27J81 S1194 Sugiyama INF2 C14orf151 C14orf173 EDEEDtAPEsALDtsLDKsFsEDAVtDssGsGtLPRARGRA
Q2VIR3 T464 Sugiyama EIF2S3B SRRVEKHWRLIGWGQIRRGVtIKPtVDDD____________
Q2VIR3 T468 Sugiyama EIF2S3B EKHWRLIGWGQIRRGVtIKPtVDDD________________
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q4G163 S192 SIGNOR FBXO43 EMI2 QNSSLESSISQVINLEKNIPsSASGFSRANNFSPLVTSTLK
Q4G163 T234 EPSD|PSP FBXO43 EMI2 EEVTSCSQKLRLNFSQQKTStIDDSKDDCSLFEVECISPIQ
Q53EL6 S76 Sugiyama PDCD4 H731 NAKAKRRLRKNssRDsGRGDsVsDsGsDALRSGLtVPtsPK
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q5H9R7 S579 Sugiyama PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q5VT52 S1177 Sugiyama RPRD2 KIAA0460 HSPC099 GGLTGFKTAPYKERAPQFQEsVGsFRsNsFNstFEHHLPPs
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q69YH5 S205 Sugiyama CDCA2 LSACQQSGFPAVLssKRRRIsYQRDsDENLTDAEGKVIGLQ
Q69YH5 S210 Sugiyama CDCA2 QSGFPAVLssKRRRIsYQRDsDENLTDAEGKVIGLQIFNID
Q6GYQ0 S797 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 EtGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDM
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7L2E3 S226 Sugiyama DHX30 DDX30 KIAA0890 DFLSMTQQDSHAPLRDSRGssFEMTDDDSAIRALTQFPLPK
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z4V5 S396 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 EDDEPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKKP
Q7Z4V5 S399 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 EPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKKPQSS
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86UF2 S140 Sugiyama CTAGE6 CTAGE6P AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86UR5 S242 SIGNOR RIMS1 KIAA0340 RAB3IP2 RIM1 Nbla00761 LSTAAASSQDAAPPSAPPDRsKGAEPSQQALGPEQKQASSR
Q86UR5 S288 SIGNOR RIMS1 KIAA0340 RAB3IP2 RIM1 Nbla00761 PRERKKTPGLSEQNGKGALKsERKRVPKTSAQPVEGAVEER
Q86V81 S145 Sugiyama ALYREF ALY BEF THOC4 LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86V81 S239 Sugiyama ALYREF ALY BEF THOC4 tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86V81 S8 Sugiyama ALYREF ALY BEF THOC4 _____________MADKMDMsLDDIIKLNRSQRGGRGGGRG
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IX94 S140 Sugiyama CTAGE4 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8IZ21 S590 Sugiyama PHACTR4 PRO2963 SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8N6H7 S368 Sugiyama ARFGAP2 ZNF289 Nbla10535 VGTFASGPPKYKDNPFsLGEsFGsRWDTDAAWGMDRVEEKE
Q8N6H7 S432 Sugiyama ARFGAP2 ZNF289 Nbla10535 RssGLEssEARQKFAGAKAIssDMFFGREVDAEyEARSRLQ
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBJ7 S281 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 ADGsANHRARVttRMGNtPDsAsDNLGFRCAADAGRPPGEL
Q8NE71 S140 Sugiyama ABCF1 ABC50 PRGGKKTKGGNVFAALIQDQsEEEEEEEKHPPKPAKPEKNR
Q8NE71 S166 Sugiyama ABCF1 ABC50 EEKHPPKPAKPEKNRINKAVsEEQQPALKGKKGKEEKSKGK
Q8NE71 T108 Sugiyama ABCF1 ABC50 VDDDGEEKELMERLKKLsVPtsDEEDEVPAPKPRGGKKTKG
Q8NHV4 S396 Sugiyama NEDD1 RsINTDtLSKEtDsGKNQDFssFDDtGKssLGDMFsPIRDD
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TEQ6 S757 Sugiyama GEMIN5 PKAKPKKKKKPTLRtPVKLEsIDGNEEEsMKENsGPVENGV
Q8WWI1 S805 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 LQDRESQNQKSTVPSRRRMysFDDVLEEGKRPPtMtVSEAS
Q8WWI1 T932 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 VtPRPFGsQtRGISsLPRsYtMDDAWKYNGDVEDIKRtPNN
Q8WX93 S479 Sugiyama PALLD KIAA0992 CGI-151 VLECRVRGAPPLQVQWFRQGsEIQDsPDFRILQKKPRSTAE
Q92736 S2808 ELM|EPSD|PSP RYR2 RIERTREGDSMALYNRTRRIsQTSQVsVDAAHGYSPRAIDM
Q92736 S2814 EPSD|PSP RYR2 EGDSMALYNRTRRIsQTSQVsVDAAHGYSPRAIDMSNVTLS
Q92804 S289 Sugiyama TAF15 RBP56 TAF2N PMINLYTDKDTGKPKGEAtVsFDDPPsAKAAIDWFDGKEFH
Q92804 T287 Sugiyama TAF15 RBP56 TAF2N GKPMINLYTDKDTGKPKGEAtVsFDDPPsAKAAIDWFDGKE
Q96A00 S130 ELM|EPSD|PSP PPP1R14A CPI17 PPP1INL ELLAKLQGLHRQPGLRQPsPsHDGsLsPLQDRARTAHP___
Q96AT1 S146 Sugiyama KIAA1143 VNQDsVKKNSQKQIKNssLLsFDNEDENE____________
Q96CT7 S141 Sugiyama CCDC124 KsHLEVPLEENVNRRVLEEGsVEARTIEDAIAVLsVAEEAA
Q96E11 S239 Sugiyama MRRF LKKSKDTVsEDtIRLIEKQIsQMADDtVAELDRHLAVKTKE
Q96IR7 S360 Sugiyama HPDL GLOXD1 LIQRQGATGFGQGNIRALWQsVQEQsARSQEA_________
Q96NW7 S1439 SIGNOR|iPTMNet LRRC7 KIAA1365 LAP1 SQATRGPQPGRCLIQTKGQRsMDGYPEQFCVRIEKNPGLGF
Q96PH1 S521 SIGNOR NOX5 KDTIWLHIRSQGQWTNRLYEsFKASDPLGRGSKRLsRSVtM
Q96PH1 S544 SIGNOR NOX5 ASDPLGRGSKRLsRSVtMRKsQRssKGSEILLEKHKFCNIK
Q96PH1 S547 SIGNOR NOX5 PLGRGSKRLsRSVtMRKsQRssKGSEILLEKHKFCNIKCYI
Q96PH1 S548 SIGNOR NOX5 LGRGSKRLsRSVtMRKsQRssKGSEILLEKHKFCNIKCYID
Q96PH1 T540 SIGNOR NOX5 EsFKASDPLGRGSKRLsRSVtMRKsQRssKGSEILLEKHKF
Q96PM5 S155 SIGNOR|EPSD|PSP RCHY1 ARNIP CHIMP PIRH2 RNF199 ZNF363 KCIENVSRQNCPICLEDIHtsRVVAHVLPCGHLLHRTCYEE
Q96PM5 T154 SIGNOR|EPSD|PSP RCHY1 ARNIP CHIMP PIRH2 RNF199 ZNF363 HKCIENVSRQNCPICLEDIHtsRVVAHVLPCGHLLHRTCYE
Q96PV0 S1073 SIGNOR|iPTMNet SYNGAP1 KIAA1938 SGGGSGGGGGGQPPPLQRGKsQQLtVSAAQKPRPSSGNLLQ
Q96PV0 S1138 SIGNOR|iPTMNet SYNGAP1 KIAA1938 SGGSGGGGGGGLKPSITKQHsQTPSTLNPTMPASERTVAWV
Q96PV0 S779 SIGNOR SYNGAP1 KIAA1938 MMRDLNSSIDLQSFMARGLNssMDMARLPSPTKEKPPPPPP
Q96PV0 S780 SIGNOR SYNGAP1 KIAA1938 MRDLNSSIDLQSFMARGLNssMDMARLPSPTKEKPPPPPPG
Q96PV0 T1077 SIGNOR|iPTMNet SYNGAP1 KIAA1938 SGGGGGGQPPPLQRGKsQQLtVSAAQKPRPSSGNLLQSPEP
Q96ST3 S158 Sugiyama SIN3A GSQPQVYNDFLDIMKEFKSQsIDtPGVISRVSQLFKGHPDL
Q99613 S39 Sugiyama EIF3C EIF3S8 GEELVTKPVGGNyGKQPLLLsEDEEDTKRVVRSAKDKRFEE
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99618 S94 Sugiyama CDCA3 C8 GRCC8 TOME1 ARtPMKTSsGDPPsPLVKQLsEVFETEDSKSNLPPEPVLPP
Q99755 S486 Sugiyama PIP5K1A GssFSRRAGssGNsCItyQPsVsGEHKAQVTTKAEVEPGVH
Q99848 T261 Sugiyama EBNA1BP2 EBP2 RRYKNQKFGFGGKKKGSKWNtREsyDDVssFRAKTAHGRGL
Q99848 Y265 Sugiyama EBNA1BP2 EBP2 NQKFGFGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPG
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BTE6 S174 Sugiyama AARSD1 IEQSVNEKIRDRLPVNVRELsLDDPEVEQVsGRGLPDDHAG
Q9BVJ6 S77 Sugiyama UTP14A SDCCAG16 NRRKLAERSEASLKVSEFNVssEGsGEKLVLADLLEPVKTS
Q9BXL7 S116 EPSD|PSP CARD11 CARMA1 EFYYPELYKLVTGKEPTRRFsTIVVEEGHEGLTHFLMNEVI
Q9BXS6 S198 Sugiyama NUSAP1 ANKT BM-037 PRO0310 TAITtPNFKKLHEAHFKEMEsIDQYIERKKKHFEEHNSMNE
Q9BXS6 S363 Sugiyama NUSAP1 ANKT BM-037 PRO0310 TtEAtQtPVsNKKPVFDLKAsLsRPLNyEPHKGKLKPWGQS
Q9BXS6 S365 Sugiyama NUSAP1 ANKT BM-037 PRO0310 EAtQtPVsNKKPVFDLKAsLsRPLNyEPHKGKLKPWGQSKE
Q9BY44 S526 Sugiyama EIF2A CDA02 MSTP004 MSTP089 sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9C0C2 S221 Sugiyama TNKS1BP1 KIAA1741 TAB182 TyGtTTAPRDEDGstLFRGWsQEGPVKsPAECREEHsKtPE
Q9C0C2 S437 Sugiyama TNKS1BP1 KIAA1741 TAB182 HLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQGsQ
Q9C0C2 S899 Sugiyama TNKS1BP1 KIAA1741 TAB182 RDVsLGDWEFGKRDsLGAyAsQDANEQGQDLGKRDHHGRys
Q9C0C2 S920 Sugiyama TNKS1BP1 KIAA1741 TAB182 QDANEQGQDLGKRDHHGRyssQDADEQDWEFQKRDVsLGTy
Q9GZZ9 S45 Sugiyama UBA5 UBE1DC1 LQVPRSGDGGGGRVRIEKMssEVVDSNPysRLMALKRMGIV
Q9H1E3 S113 Sugiyama NUCKS1 NUCKS JC7 RQAASKAASKQREMLMEDVGsEEEQEEEDEAPFQEKDsGsD
Q9H254 S2254 PSP SPTBN4 KIAA1642 SPTBN3 QEsADRAEELPRRRRPERQEsVDQSEEAARRRRPERQESAE
Q9H6S3 S693 Sugiyama EPS8L2 EPS8R2 PP13181 EGVRVySQLTMQKAFLEKQQsGSELEELMNKFHSMNQRRGE
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9NP61 S366 Sugiyama ARFGAP3 ARFGAP1 DDsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKD
Q9NQC7 S362 SIGNOR|PSP CYLD CYLD1 KIAA0849 HSPC057 STSDPGNRNRSELFYTLNGSsVDSQPQSKSKNTWYIDEVAE
Q9NQC7 S418 PSP CYLD CYLD1 KIAA0849 HSPC057 ssPPLQPPPVNSLTTENRFHsLPFsLtKMPNTNGsIGHsPL
Q9NQC7 S772 SIGNOR|PSP CYLD CYLD1 KIAA0849 HSPC057 LIIQMPRFGKDFKLFKKIFPsLELNITDLLEDTPRQCRICG
Q9NQW6 S225 Sugiyama ANLN LAATICsWEDDVNHsFAKQNsVQEQPGTACLSKFSSASGAs
Q9NR30 S706 Sugiyama DDX21 PTASVTEIQEKWHDSRRWQLsVATEQPELEGPREGYGGFRG
Q9NSA2 S555 PSP KCND1 RRAKRRAIRLANSTASVSRGsMQELDMLAGLRRsHAPQSRS
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NSC5 S120 SIGNOR HOMER3 TQFAEKFQEVKEAARLAREKsQDGGELtsPALGLAsHQVPP
Q9NSC5 S159 SIGNOR HOMER3 PPsPLVSANGPGEEKLFRsQsADAPGPTERERLKKMLsEGS
Q9NSC5 S176 SIGNOR HOMER3 RsQsADAPGPTERERLKKMLsEGSVGEVQWEAEFFALQDSN
Q9NUU7 T467 Sugiyama DDX19A DDX19L SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9NZV8 S438 ELM KCND2 KIAA1044 RADKRRAQKKARLARIRAAKsGSANAYMQSKRNGLLSNQLQ
Q9NZV8 S459 ELM KCND2 KIAA1044 GSANAYMQSKRNGLLSNQLQsSEDEQAFVSKSGSSFETQHH
Q9P0L9 T591 SIGNOR PKD2L1 PKD2L PKDL TRPP3 LAGQKDELQLsDLLKQGYNKtLLRLRLRKERVSDVQKVLQG
Q9UBS5 S868 SIGNOR GABBR1 GPRC3A TLVVLFVPKMRRLITRGEWQsEAQDtMKTGSstNNNEEEKS
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKV3 S661 Sugiyama ACIN1 ACINUS KIAA0670 SRSRSRSASSNSRKsLsPGVsRDsstsytEtKDPssGQEVA
Q9ULD2 S1203 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9UMR2 T468 Sugiyama DDX19B DBP5 DDX19 TDBP SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UNZ2 S192 Sugiyama NSFL1C UBXN2C KRQHssQDVHVVLKLWKsGFsLDNGELRSyQDPsNAQFLEs
Q9UPQ0 S201 Sugiyama LIMCH1 KIAA1102 DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQ35 S1537 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sGsEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERs
Q9UQ35 S1653 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 PRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTARRGsR
Q9UQ35 S854 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sHSsssPHPKVKsGtPPRQGsItsPQANEQsVtPQRRsCFE
Q9UQ35 T848 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 KtPsRQsHSsssPHPKVKsGtPPRQGsItsPQANEQsVtPQ
Q9UQD0 S541 PSP SCN8A MED EDGMRRKAFRLPDNRIGRKFsIMNQSLLSIPGSPFLSRHNs
Q9UQD0 S561 SIGNOR|PSP SCN8A MED sIMNQSLLSIPGSPFLSRHNsKSSIFSFRGPGRFRDPGSEN
Q9UQD0 S641 SIGNOR|PSP SCN8A MED SQGSRSSRIFPSLRRSVKRNstVDCNGVVSLIGGPGSHIGG
Q9UQD0 T642 SIGNOR|PSP SCN8A MED QGSRSSRIFPSLRRSVKRNstVDCNGVVSLIGGPGSHIGGR
Q9UQL6 S259 EPSD|PSP HDAC5 KIAA0600 KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9UQL6 S498 EPSD|PSP HDAC5 KIAA0600 ATSMRTVGKLPRHRPLSRtQssPLPQSPQALQQLVMQQQHQ
Q9UQM7 S25 Sugiyama CAMK2A CAMKA KIAA0968 TCTRFTEEYQLFEELGKGAFsVVRRCVKVLAGQEYAAKIIN
Q9UQM7 S314 SIGNOR CAMK2A CAMKA KIAA0968 NARRKLKGAILttMLAtRNFsGGKSGGNKKSDGVKEssEst
Q9UQM7 T261 Sugiyama CAMK2A CAMKA KIAA0968 TPEAKDLINKMLtINPsKRItAAEALKHPWISHRStVAsCM
Q9UQM7 T286 SIGNOR|ELM|EPSD|PSP CAMK2A CAMKA KIAA0968 LKHPWISHRStVAsCMHRQEtVDCLKKFNARRKLKGAILtt
Q9UQM7 T305 SIGNOR|EPSD|PSP|Sugiyama CAMK2A CAMKA KIAA0968 EtVDCLKKFNARRKLKGAILttMLAtRNFsGGKSGGNKKSD
Q9UQM7 T306 SIGNOR|EPSD|PSP|Sugiyama CAMK2A CAMKA KIAA0968 tVDCLKKFNARRKLKGAILttMLAtRNFsGGKSGGNKKSDG
Q9Y281 S24 ELM CFL2 GVtVNDEVIKVFNDMKVRKsstQEEIKKRKKAVLFCLSDDK
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0 S178 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 NVKDKLCSKRtDLCDHALHIsHDEL________________
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7 S137 Sugiyama YBX2 CSDA3 MSY2 EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y2X7 S592 Sugiyama GIT1 PLLsCsQEGsRHtsKLsRHGsGADsDyENtQSGDPLLGLEG
Q9Y383 S347 Sugiyama LUC7L2 CGI-59 CGI-74 SRERSKRRSSKERFRDQDLAsCDRDRssRDRSPRDRDRKDK
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y496 S687 EPSD|PSP KIF3A KIF3 LERPRtSKGKARPKTGRRKRsAKPEtVIDSLLQ________
Q9Y4D2 S782 SIGNOR|EPSD|PSP DAGLA C11orf11 KIAA0659 NSDDR TQERLAAELQARRAPLATMEsLSDTESLYSFDSRRSsGFRS
Q9Y4D2 S808 SIGNOR|EPSD|PSP DAGLA C11orf11 KIAA0659 NSDDR SLYSFDSRRSsGFRSIRGsPsLHAVLERDEGHLFYIDPAIP
Q9Y4P3 T433 Sugiyama TBL2 WBSCR13 UNQ563/PRO1125 QGHLKRASNESTRQRLQQQLtQAQETLKSLGALKK______
Q9Y4W2 S641 Sugiyama LAS1L MSTP060 ENARLLAQKRGALQGsAWQVssEDVRWDTFPLGRMPGQTED
Q9Y5B9 S650 Sugiyama SUPT16H FACT140 FACTP140 KRYKTREAEEKEKEGIVKQDsLVINLNRsNPKLKDLYIRPN
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y618 S2426 SIGNOR|PSP NCOR2 CTG26 PsSRKAKsPAPGLASGDRPPsVSSVHSEGDCNRRTPLTNRV
Q9Y618 S2453 PSP NCOR2 CTG26 EGDCNRRTPLTNRVWEDRPSsAGSTPFPYNPLIMRLQAGVM
Q9Y6K9 S196 Sugiyama IKBKG FIP3 NEMO AASEQARQLESEREALQQQHsVQVDQLRMQGQSVEAALRME
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.221479e-08 7.913 0 0
Cell Cycle Checkpoints R-HSA-69620 9.818097e-08 7.008 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.355963e-07 6.271 0 0
Cell Cycle, Mitotic R-HSA-69278 1.143341e-06 5.942 0 0
NRAGE signals death through JNK R-HSA-193648 1.466455e-06 5.834 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.329720e-06 5.633 0 0
M Phase R-HSA-68886 3.244286e-06 5.489 0 0
Chromatin organization R-HSA-4839726 4.839737e-06 5.315 0 0
Chromatin modifying enzymes R-HSA-3247509 6.952948e-06 5.158 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.521582e-06 5.069 0 0
Mitotic Prophase R-HSA-68875 9.292517e-06 5.032 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.013282e-05 4.696 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.785766e-05 4.422 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.347893e-05 4.362 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.898475e-05 4.310 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.462570e-05 4.263 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.675803e-05 4.175 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.495854e-05 4.187 0 0
G alpha (12/13) signalling events R-HSA-416482 6.087633e-05 4.216 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 6.294185e-05 4.201 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.631601e-05 4.117 0 0
Axon guidance R-HSA-422475 1.241743e-04 3.906 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.135985e-04 3.670 0 0
Nervous system development R-HSA-9675108 2.115500e-04 3.675 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.270603e-04 3.644 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.257219e-04 3.646 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.479910e-04 3.606 1 0
Processing of DNA double-strand break ends R-HSA-5693607 2.515802e-04 3.599 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.555997e-04 3.592 1 0
Nucleosome assembly R-HSA-774815 2.900742e-04 3.537 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.900742e-04 3.537 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.247182e-04 3.488 1 0
Signaling by RAF1 mutants R-HSA-9656223 3.561499e-04 3.448 1 1
Ub-specific processing proteases R-HSA-5689880 3.412422e-04 3.467 0 0
Apoptotic execution phase R-HSA-75153 3.575551e-04 3.447 0 0
Mitotic Prometaphase R-HSA-68877 3.810266e-04 3.419 0 0
Signaling by Hippo R-HSA-2028269 3.828740e-04 3.417 0 0
Homology Directed Repair R-HSA-5693538 3.797496e-04 3.421 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.157079e-04 3.381 0 0
HATs acetylate histones R-HSA-3214847 4.568619e-04 3.340 0 0
Meiotic synapsis R-HSA-1221632 5.159274e-04 3.287 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.430405e-04 3.265 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.791111e-04 3.237 0 0
G2/M Checkpoints R-HSA-69481 6.112346e-04 3.214 0 0
mRNA Splicing R-HSA-72172 6.381762e-04 3.195 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 6.641130e-04 3.178 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.732381e-04 3.172 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.853893e-04 3.164 0 0
Post NMDA receptor activation events R-HSA-438064 7.160107e-04 3.145 1 0
mRNA Splicing - Major Pathway R-HSA-72163 7.556327e-04 3.122 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.660591e-04 3.116 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.799947e-04 3.108 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.244537e-04 3.084 0 0
DNA Double Strand Break Response R-HSA-5693606 8.983703e-04 3.047 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.015938e-03 2.993 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.820681e-04 3.008 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.820681e-04 3.008 1 1
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.820681e-04 3.008 1 1
Regulation of MECP2 expression and activity R-HSA-9022692 1.015938e-03 2.993 1 1
Signaling by RAS mutants R-HSA-6802949 9.820681e-04 3.008 1 0
Deubiquitination R-HSA-5688426 9.677434e-04 3.014 0 0
Death Receptor Signaling R-HSA-73887 1.062689e-03 2.974 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.110039e-03 2.955 0 0
Neurexins and neuroligins R-HSA-6794361 1.118947e-03 2.951 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.201272e-03 2.920 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.201272e-03 2.920 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.559438e-03 2.807 1 1
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.759196e-03 2.755 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.759196e-03 2.755 1 1
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.759196e-03 2.755 1 1
HDACs deacetylate histones R-HSA-3214815 1.854530e-03 2.732 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.178086e-03 2.662 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.288054e-03 2.641 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.270678e-03 2.644 1 0
Meiosis R-HSA-1500620 2.270678e-03 2.644 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.179847e-03 2.662 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.279289e-03 2.642 0 0
Cellular Senescence R-HSA-2559583 2.144199e-03 2.669 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.314336e-03 2.636 0 0
RET signaling R-HSA-8853659 2.362574e-03 2.627 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.959292e-03 2.529 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.857826e-03 2.544 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.854489e-03 2.544 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.857826e-03 2.544 1 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.964991e-03 2.528 0 0
Gene Silencing by RNA R-HSA-211000 2.811122e-03 2.551 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.285260e-03 2.483 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.414362e-03 2.467 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.480977e-03 2.458 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.692508e-03 2.433 0 0
DNA methylation R-HSA-5334118 3.709534e-03 2.431 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.963608e-03 2.402 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.771325e-03 2.424 0 0
Cell-Cell communication R-HSA-1500931 3.772064e-03 2.423 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.084814e-03 2.389 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.555028e-03 2.342 0 0
Long-term potentiation R-HSA-9620244 4.620227e-03 2.335 1 1
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.726401e-03 2.325 0 0
Signal Transduction R-HSA-162582 5.014163e-03 2.300 1 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.232898e-03 2.281 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.546684e-03 2.256 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.546684e-03 2.256 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.715900e-03 2.243 1 1
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.981896e-03 2.223 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.981896e-03 2.223 0 0
Meiotic recombination R-HSA-912446 5.638730e-03 2.249 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.814951e-03 2.235 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.559028e-03 2.255 0 0
Centrosome maturation R-HSA-380287 6.052983e-03 2.218 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.229290e-03 2.206 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.373338e-03 2.196 0 0
Signaling by VEGF R-HSA-194138 6.425354e-03 2.192 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.383889e-03 2.132 0 0
Packaging Of Telomere Ends R-HSA-171306 7.018710e-03 2.154 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.454138e-03 2.128 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.454138e-03 2.128 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.339758e-03 2.134 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.018710e-03 2.154 0 0
Mitotic Anaphase R-HSA-68882 7.620052e-03 2.118 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.035369e-03 2.095 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.143530e-03 2.089 0 0
DCC mediated attractive signaling R-HSA-418885 8.421277e-03 2.075 0 0
Protein-protein interactions at synapses R-HSA-6794362 9.403636e-03 2.027 0 0
Gene expression (Transcription) R-HSA-74160 9.421508e-03 2.026 1 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.028818e-02 1.988 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.028818e-02 1.988 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 9.831600e-03 2.007 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.028346e-02 1.988 0 0
Striated Muscle Contraction R-HSA-390522 9.567241e-03 2.019 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 9.567241e-03 2.019 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.030685e-02 1.987 0 0
PI Metabolism R-HSA-1483255 1.041902e-02 1.982 0 0
Reproduction R-HSA-1474165 1.077708e-02 1.967 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.078132e-02 1.967 1 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.080927e-02 1.966 0 0
RSK activation R-HSA-444257 1.080927e-02 1.966 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.080927e-02 1.966 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.091585e-02 1.962 0 0
RAF activation R-HSA-5673000 1.131470e-02 1.946 1 1
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.113489e-02 1.953 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.201778e-02 1.920 0 0
Nephrin family interactions R-HSA-373753 1.113915e-02 1.953 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.122978e-02 1.950 0 0
Nuclear import of Rev protein R-HSA-180746 1.131470e-02 1.946 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.131470e-02 1.946 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.229123e-02 1.910 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.252841e-02 1.902 0 0
DNA Repair R-HSA-73894 1.284884e-02 1.891 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.365242e-02 1.865 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.398599e-02 1.854 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.443819e-02 1.840 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.459136e-02 1.836 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.518567e-02 1.819 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.561062e-02 1.807 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.601254e-02 1.796 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.685760e-02 1.773 0 0
G0 and Early G1 R-HSA-1538133 1.719220e-02 1.765 0 0
MAP2K and MAPK activation R-HSA-5674135 1.608472e-02 1.794 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.624953e-02 1.789 0 0
RNA Polymerase I Transcription R-HSA-73864 1.683532e-02 1.774 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.786904e-02 1.748 0 0
Signaling by ALK in cancer R-HSA-9700206 1.786904e-02 1.748 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.719220e-02 1.765 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.885816e-02 1.725 0 0
MAPK family signaling cascades R-HSA-5683057 1.958713e-02 1.708 1 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.012018e-02 1.696 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.061056e-02 1.686 1 1
Separation of Sister Chromatids R-HSA-2467813 2.073753e-02 1.683 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.244394e-02 1.649 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.341060e-02 1.631 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.156772e-02 1.666 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.339648e-02 1.631 0 0
CREB phosphorylation R-HSA-199920 2.341060e-02 1.631 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.082458e-02 1.681 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.392187e-02 1.621 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.392187e-02 1.621 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.402512e-02 1.619 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.407385e-02 1.618 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.472853e-02 1.607 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.632435e-02 1.580 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.716511e-02 1.566 0 0
DAG and IP3 signaling R-HSA-1489509 2.722165e-02 1.565 1 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.734163e-02 1.563 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.734163e-02 1.563 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.174969e-02 1.498 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.174969e-02 1.498 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.174969e-02 1.498 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.174969e-02 1.498 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.174969e-02 1.498 0 0
mRNA 3'-end processing R-HSA-72187 3.005046e-02 1.522 0 0
Metabolism of non-coding RNA R-HSA-194441 3.245354e-02 1.489 0 0
snRNP Assembly R-HSA-191859 3.245354e-02 1.489 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.109997e-02 1.507 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.258276e-02 1.487 0 0
Cell junction organization R-HSA-446728 3.364891e-02 1.473 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.141356e-02 1.503 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.109997e-02 1.507 0 0
Recycling pathway of L1 R-HSA-437239 3.452271e-02 1.462 0 0
Activation of RAC1 R-HSA-428540 3.491258e-02 1.457 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.491258e-02 1.457 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.521215e-02 1.453 1 1
Trafficking of AMPA receptors R-HSA-399719 3.523985e-02 1.453 1 1
Membrane Trafficking R-HSA-199991 3.527911e-02 1.452 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.551305e-02 1.450 0 0
Calmodulin induced events R-HSA-111933 3.551305e-02 1.450 1 0
CaM pathway R-HSA-111997 3.551305e-02 1.450 1 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 3.559307e-02 1.449 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.559307e-02 1.449 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.559307e-02 1.449 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.565795e-02 1.448 0 0
G2/M Transition R-HSA-69275 3.577137e-02 1.446 0 0
Chromosome Maintenance R-HSA-73886 3.650214e-02 1.438 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.757696e-02 1.425 0 0
Type I hemidesmosome assembly R-HSA-446107 4.357894e-02 1.361 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.389741e-02 1.358 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.389741e-02 1.358 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.389741e-02 1.358 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.389741e-02 1.358 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.389741e-02 1.358 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.138991e-02 1.383 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.975501e-02 1.401 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.157873e-02 1.381 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.982191e-02 1.400 0 0
L1CAM interactions R-HSA-373760 4.169560e-02 1.380 0 0
Ca-dependent events R-HSA-111996 3.969234e-02 1.401 1 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 4.037429e-02 1.394 0 0
tRNA processing in the nucleus R-HSA-6784531 4.381337e-02 1.358 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.998206e-02 1.398 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.801634e-02 1.420 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.357894e-02 1.361 0 0
Cleavage of the damaged purine R-HSA-110331 4.037429e-02 1.394 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.969234e-02 1.401 0 0
Depyrimidination R-HSA-73928 3.969234e-02 1.401 0 0
Defective pyroptosis R-HSA-9710421 4.455359e-02 1.351 0 0
Metabolism of RNA R-HSA-8953854 4.482316e-02 1.348 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.558870e-02 1.341 0 0
Depurination R-HSA-73927 4.567291e-02 1.340 0 0
Signaling by EGFR R-HSA-177929 4.590550e-02 1.338 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.612514e-02 1.336 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.629108e-02 1.335 1 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.971538e-02 1.304 0 0
Specification of primordial germ cells R-HSA-9827857 4.971538e-02 1.304 0 0
Netrin-1 signaling R-HSA-373752 4.980762e-02 1.303 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.190182e-02 1.285 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.245772e-02 1.280 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.546477e-02 1.256 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.641044e-02 1.249 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.829424e-02 1.234 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.862759e-02 1.232 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.862759e-02 1.232 0 0
Regulation of TP53 Activity R-HSA-5633007 5.864076e-02 1.232 0 0
Ephrin signaling R-HSA-3928664 5.899772e-02 1.229 0 0
Polo-like kinase mediated events R-HSA-156711 5.899772e-02 1.229 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.899772e-02 1.229 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.118587e-02 1.148 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 7.118587e-02 1.148 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 7.118587e-02 1.148 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.104594e-02 1.148 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.104594e-02 1.148 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.984681e-02 1.156 0 0
Deadenylation of mRNA R-HSA-429947 6.984681e-02 1.156 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.060226e-02 1.218 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.452972e-02 1.190 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.216883e-02 1.206 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.511016e-02 1.186 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.983891e-02 1.156 0 0
PI3K/AKT activation R-HSA-198203 7.104594e-02 1.148 0 0
Cilium Assembly R-HSA-5617833 6.469979e-02 1.189 0 0
S Phase R-HSA-69242 6.703213e-02 1.174 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.431467e-02 1.192 0 0
Rap1 signalling R-HSA-392517 6.924514e-02 1.160 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.060226e-02 1.218 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.118587e-02 1.148 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 7.118587e-02 1.148 0 0
Rab regulation of trafficking R-HSA-9007101 7.043603e-02 1.152 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.680124e-02 1.175 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.153387e-02 1.211 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.603115e-02 1.180 0 0
PLC beta mediated events R-HSA-112043 7.286715e-02 1.137 1 0
RAF/MAP kinase cascade R-HSA-5673001 7.418119e-02 1.130 1 1
Diseases of programmed cell death R-HSA-9645723 7.629671e-02 1.117 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 7.843865e-02 1.105 0 0
Heme signaling R-HSA-9707616 7.927944e-02 1.101 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.976621e-02 1.098 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.976621e-02 1.098 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.976621e-02 1.098 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.020053e-02 1.096 0 0
Regulation of cortical dendrite branching R-HSA-8985801 8.260994e-02 1.083 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 8.277358e-02 1.082 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 8.277358e-02 1.082 0 0
Signaling by ROBO receptors R-HSA-376176 8.414551e-02 1.075 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.604104e-02 1.065 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.700473e-02 1.060 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.713518e-02 1.060 0 0
Signaling by APC mutants R-HSA-4839744 8.742101e-02 1.058 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 8.742101e-02 1.058 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 8.742101e-02 1.058 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 8.742101e-02 1.058 0 0
Cellular response to heat stress R-HSA-3371556 8.922289e-02 1.050 1 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.119056e-01 0.951 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.119056e-01 0.951 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.119056e-01 0.951 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.119056e-01 0.951 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.119056e-01 0.951 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.119056e-01 0.951 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.119056e-01 0.951 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 9.318582e-02 1.031 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 9.318582e-02 1.031 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 9.318582e-02 1.031 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.054427e-01 0.977 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.244659e-02 1.034 0 0
Differentiation of T cells R-HSA-9945266 9.244659e-02 1.034 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 9.244659e-02 1.034 0 0
Disorders of Developmental Biology R-HSA-9675151 1.076441e-01 0.968 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.076441e-01 0.968 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.076441e-01 0.968 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.045898e-02 1.044 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.019159e-01 0.992 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.084044e-01 0.965 0 0
Integrin signaling R-HSA-354192 9.727243e-02 1.012 0 0
EPH-Ephrin signaling R-HSA-2682334 1.063793e-01 0.973 0 0
RNA Polymerase II Transcription R-HSA-73857 9.244566e-02 1.034 1 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.079777e-01 0.967 0 0
Regulation of CDH1 Function R-HSA-9764561 9.194957e-02 1.036 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.358052e-02 1.029 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.057135e-01 0.976 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.115306e-01 0.953 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.054427e-01 0.977 0 0
Signaling by AXIN mutants R-HSA-4839735 1.054427e-01 0.977 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.636533e-02 1.016 1 0
Muscle contraction R-HSA-397014 9.389949e-02 1.027 1 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.076441e-01 0.968 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.585813e-02 1.018 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.194957e-02 1.036 0 0
IRE1alpha activates chaperones R-HSA-381070 9.985177e-02 1.001 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.141218e-01 0.943 1 1
G-protein mediated events R-HSA-112040 1.165989e-01 0.933 1 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.175948e-01 0.930 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.175948e-01 0.930 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.175948e-01 0.930 0 0
Regulation of PTEN localization R-HSA-8948747 1.175948e-01 0.930 0 0
Disinhibition of SNARE formation R-HSA-114516 1.175948e-01 0.930 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.175948e-01 0.930 0 0
Glycolysis R-HSA-70171 1.185177e-01 0.926 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.194492e-01 0.923 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.194492e-01 0.923 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.197016e-01 0.922 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.197016e-01 0.922 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.197016e-01 0.922 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.197016e-01 0.922 0 0
Notch-HLH transcription pathway R-HSA-350054 1.197113e-01 0.922 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.197113e-01 0.922 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.249951e-01 0.903 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.249951e-01 0.903 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.254289e-01 0.902 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.255414e-01 0.901 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.302804e-01 0.885 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.314625e-01 0.881 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.339385e-01 0.873 0 0
Co-stimulation by CD28 R-HSA-389356 1.350959e-01 0.869 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.599825e-01 0.796 0 0
TNFR1-mediated ceramide production R-HSA-5626978 1.599825e-01 0.796 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.599825e-01 0.796 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.599825e-01 0.796 0 0
Formation of annular gap junctions R-HSA-196025 1.440801e-01 0.841 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.440801e-01 0.841 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.440801e-01 0.841 0 0
Lipophagy R-HSA-9613354 1.722993e-01 0.764 0 0
Gap junction degradation R-HSA-190873 1.722993e-01 0.764 0 0
Calcineurin activates NFAT R-HSA-2025928 1.722993e-01 0.764 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.459445e-01 0.836 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.459445e-01 0.836 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.681443e-01 0.774 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.681443e-01 0.774 0 0
GAB1 signalosome R-HSA-180292 1.413748e-01 0.850 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.597650e-01 0.797 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.790623e-01 0.747 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.790623e-01 0.747 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.855039e-01 0.732 0 0
Downstream signal transduction R-HSA-186763 1.550049e-01 0.810 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.413748e-01 0.850 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.597650e-01 0.797 0 0
EGFR downregulation R-HSA-182971 1.550049e-01 0.810 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.722993e-01 0.764 0 0
Platelet sensitization by LDL R-HSA-432142 1.413748e-01 0.850 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.837526e-01 0.736 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 1.667249e-01 0.778 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.722993e-01 0.764 0 0
PI3K Cascade R-HSA-109704 1.574727e-01 0.803 0 0
Telomere Maintenance R-HSA-157579 1.508770e-01 0.821 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.869824e-01 0.728 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.597650e-01 0.797 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.599825e-01 0.796 0 0
Dopamine receptors R-HSA-390651 1.599825e-01 0.796 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.599825e-01 0.796 0 0
Adrenoceptors R-HSA-390696 1.440801e-01 0.841 0 0
Nuclear RNA decay R-HSA-9930044 1.855039e-01 0.732 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.502633e-01 0.823 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.709693e-01 0.767 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.460638e-01 0.835 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.460638e-01 0.835 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.406942e-01 0.852 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.406942e-01 0.852 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.855039e-01 0.732 0 0
DNA Replication R-HSA-69306 1.724183e-01 0.763 0 0
MTOR signalling R-HSA-165159 1.456658e-01 0.837 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.554724e-01 0.808 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 1.839058e-01 0.735 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.478476e-01 0.830 0 0
Signaling by SCF-KIT R-HSA-1433557 1.578903e-01 0.802 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.527888e-01 0.816 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.855039e-01 0.732 0 0
Neurodegenerative Diseases R-HSA-8863678 1.502633e-01 0.823 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.502633e-01 0.823 0 0
HDMs demethylate histones R-HSA-3214842 1.667249e-01 0.778 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.440801e-01 0.841 0 0
Co-stimulation by ICOS R-HSA-9927354 1.440801e-01 0.841 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 1.722993e-01 0.764 0 0
TBC/RABGAPs R-HSA-8854214 1.578903e-01 0.802 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.837526e-01 0.736 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.855039e-01 0.732 0 0
FLT3 signaling in disease R-HSA-9682385 1.440688e-01 0.841 0 0
Negative regulation of MET activity R-HSA-6807004 1.790623e-01 0.747 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.457861e-01 0.836 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.459445e-01 0.836 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.597531e-01 0.797 0 0
Amyloid fiber formation R-HSA-977225 1.792819e-01 0.746 0 0
Apoptosis R-HSA-109581 1.818302e-01 0.740 0 0
Interleukin-7 signaling R-HSA-1266695 1.667249e-01 0.778 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.722993e-01 0.764 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.722993e-01 0.764 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.896281e-01 0.722 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.914393e-01 0.718 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.914393e-01 0.718 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.914393e-01 0.718 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.914393e-01 0.718 0 0
p75NTR signals via NF-kB R-HSA-193639 1.914393e-01 0.718 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.914393e-01 0.718 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.939241e-01 0.712 0 0
Protein ubiquitination R-HSA-8852135 1.939241e-01 0.712 0 0
Smooth Muscle Contraction R-HSA-445355 1.941906e-01 0.712 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.951174e-01 0.710 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.973462e-01 0.705 0 0
Diseases of DNA repair R-HSA-9675135 1.973462e-01 0.705 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.984002e-01 0.702 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.112941e-01 0.675 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.112941e-01 0.675 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.112941e-01 0.675 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.112941e-01 0.675 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.112941e-01 0.675 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.112941e-01 0.675 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.112941e-01 0.675 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.112941e-01 0.675 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.112941e-01 0.675 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.112941e-01 0.675 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.112941e-01 0.675 0 0
FGFR4 mutant receptor activation R-HSA-1839128 2.995651e-01 0.524 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.995651e-01 0.524 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.995651e-01 0.524 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.995651e-01 0.524 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.995651e-01 0.524 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.995651e-01 0.524 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.995651e-01 0.524 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.995651e-01 0.524 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.022752e-01 0.694 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.022752e-01 0.694 0 0
IRS activation R-HSA-74713 2.022752e-01 0.694 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.022752e-01 0.694 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.022752e-01 0.694 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.022752e-01 0.694 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.022752e-01 0.694 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.456256e-01 0.610 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.456256e-01 0.610 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.456256e-01 0.610 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.456256e-01 0.610 0 0
Phosphorylation of Emi1 R-HSA-176417 2.456256e-01 0.610 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.779614e-01 0.423 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.779614e-01 0.423 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.779614e-01 0.423 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.779614e-01 0.423 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.779614e-01 0.423 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.779614e-01 0.423 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.779614e-01 0.423 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.779614e-01 0.423 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.779614e-01 0.423 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.779614e-01 0.423 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.779614e-01 0.423 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.779614e-01 0.423 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.779614e-01 0.423 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.779614e-01 0.423 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.779614e-01 0.423 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 3.779614e-01 0.423 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.779614e-01 0.423 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.779614e-01 0.423 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.779614e-01 0.423 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.779614e-01 0.423 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.019128e-01 0.695 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.019128e-01 0.695 0 0
Chylomicron clearance R-HSA-8964026 2.892680e-01 0.539 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 2.892680e-01 0.539 0 0
PECAM1 interactions R-HSA-210990 2.325928e-01 0.633 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.325928e-01 0.633 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.156699e-01 0.666 0 0
Phosphorylation of the APC/C R-HSA-176412 2.156699e-01 0.666 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.156699e-01 0.666 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.325943e-01 0.478 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.325943e-01 0.478 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.325943e-01 0.478 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.325943e-01 0.478 0 0
VLDL clearance R-HSA-8964046 3.325943e-01 0.478 0 0
SOS-mediated signalling R-HSA-112412 3.325943e-01 0.478 0 0
MET activates PTPN11 R-HSA-8865999 4.475873e-01 0.349 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.991767e-01 0.701 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.406752e-01 0.619 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.406752e-01 0.619 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.959358e-01 0.529 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.959358e-01 0.529 0 0
Pervasive developmental disorders R-HSA-9005895 2.959358e-01 0.529 0 0
Disorders of Nervous System Development R-HSA-9697154 2.959358e-01 0.529 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.959358e-01 0.529 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.017472e-01 0.695 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.017472e-01 0.695 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 2.662959e-01 0.575 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.662959e-01 0.575 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.751289e-01 0.426 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.751289e-01 0.426 0 0
HIV elongation arrest and recovery R-HSA-167287 2.201869e-01 0.657 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.201869e-01 0.657 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.280492e-01 0.484 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.280492e-01 0.484 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.923772e-01 0.534 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.858914e-01 0.544 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.601338e-01 0.444 0 0
ARMS-mediated activation R-HSA-170984 4.165067e-01 0.380 0 0
WNT mediated activation of DVL R-HSA-201688 4.165067e-01 0.380 0 0
ALK mutants bind TKIs R-HSA-9700645 4.165067e-01 0.380 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.094234e-01 0.293 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.094234e-01 0.293 0 0
betaKlotho-mediated ligand binding R-HSA-1307965 5.094234e-01 0.293 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 5.094234e-01 0.293 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.094234e-01 0.293 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.094234e-01 0.293 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.094234e-01 0.293 0 0
RUNX2 regulates bone development R-HSA-8941326 2.528426e-01 0.597 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.528426e-01 0.597 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.086469e-01 0.511 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.453332e-01 0.462 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 3.453332e-01 0.462 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.919803e-01 0.407 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.919803e-01 0.407 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.919803e-01 0.407 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.919803e-01 0.407 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.101217e-01 0.678 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.564537e-01 0.341 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.564537e-01 0.341 0 0
2-LTR circle formation R-HSA-164843 4.564537e-01 0.341 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.074106e-01 0.512 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.469580e-01 0.607 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.396779e-01 0.469 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.396779e-01 0.469 0 0
HIV Transcription Elongation R-HSA-167169 3.261081e-01 0.487 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.261081e-01 0.487 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.261081e-01 0.487 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.984500e-01 0.400 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.779882e-01 0.423 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.779882e-01 0.423 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.779882e-01 0.423 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.067979e-01 0.513 0 0
Late endosomal microautophagy R-HSA-9615710 4.011699e-01 0.397 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 4.247682e-01 0.372 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.947721e-01 0.306 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.643410e-01 0.248 0 0
Defective F9 activation R-HSA-9673221 5.643410e-01 0.248 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.643410e-01 0.248 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.643410e-01 0.248 0 0
HCMV Early Events R-HSA-9609690 2.099048e-01 0.678 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.838367e-01 0.416 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.843873e-01 0.315 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.201279e-01 0.495 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.313260e-01 0.275 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.172153e-01 0.380 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.369302e-01 0.360 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.136987e-01 0.289 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.136987e-01 0.289 0 0
Tight junction interactions R-HSA-420029 5.015668e-01 0.300 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.535007e-01 0.343 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.632174e-01 0.334 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.894187e-01 0.310 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.261768e-01 0.279 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 5.420966e-01 0.266 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.420966e-01 0.266 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.420966e-01 0.266 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.660303e-01 0.247 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.660303e-01 0.247 0 0
Polymerase switching R-HSA-69091 5.660303e-01 0.247 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.660303e-01 0.247 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.660303e-01 0.247 0 0
Leading Strand Synthesis R-HSA-69109 5.660303e-01 0.247 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.243725e-01 0.280 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.501818e-01 0.259 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.695096e-01 0.244 0 0
Lagging Strand Synthesis R-HSA-69186 5.958835e-01 0.225 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.958835e-01 0.225 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.856096e-01 0.232 0 0
FOXO-mediated transcription R-HSA-9614085 5.432249e-01 0.265 0 0
RNA Polymerase III Transcription R-HSA-74158 2.528426e-01 0.597 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.958835e-01 0.225 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.958835e-01 0.225 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.246081e-01 0.489 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.620223e-01 0.335 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.620223e-01 0.335 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.843873e-01 0.315 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.843873e-01 0.315 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.436129e-01 0.353 0 0
DNA strand elongation R-HSA-69190 4.698307e-01 0.328 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.586000e-01 0.587 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.028484e-01 0.693 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.987320e-01 0.399 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.662959e-01 0.575 0 0
Circadian clock R-HSA-9909396 5.861609e-01 0.232 0 0
Prolonged ERK activation events R-HSA-169893 4.234058e-01 0.373 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.987320e-01 0.399 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.987320e-01 0.399 0 0
IRS-mediated signalling R-HSA-112399 2.482477e-01 0.605 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.719341e-01 0.430 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.011699e-01 0.397 0 0
Activation of the pre-replicative complex R-HSA-68962 4.242517e-01 0.372 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.156699e-01 0.666 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.449763e-01 0.462 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.542527e-01 0.343 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.242517e-01 0.372 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.787837e-01 0.555 0 0
Integration of provirus R-HSA-162592 5.313260e-01 0.275 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.856096e-01 0.232 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.894108e-01 0.230 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.923772e-01 0.534 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.775385e-01 0.321 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.528426e-01 0.597 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.564537e-01 0.341 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.936895e-01 0.405 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.353293e-01 0.628 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.414777e-01 0.617 0 0
Synthesis of DNA R-HSA-69239 5.488780e-01 0.261 0 0
Signaling by FGFR4 R-HSA-5654743 5.629577e-01 0.250 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.165067e-01 0.380 0 0
Regulation of CDH11 function R-HSA-9762292 4.564537e-01 0.341 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.234058e-01 0.373 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.082338e-01 0.681 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.247682e-01 0.372 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.947721e-01 0.306 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.313260e-01 0.275 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.358172e-01 0.271 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.469580e-01 0.607 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.229198e-01 0.374 0 0
Signalling to ERKs R-HSA-187687 5.569718e-01 0.254 0 0
TCR signaling R-HSA-202403 4.803000e-01 0.318 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.727444e-01 0.564 0 0
Semaphorin interactions R-HSA-373755 2.281246e-01 0.642 0 0
NF-kB is activated and signals survival R-HSA-209560 2.640295e-01 0.578 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.751289e-01 0.426 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.923772e-01 0.534 0 0
Unwinding of DNA R-HSA-176974 4.165067e-01 0.380 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.165067e-01 0.380 0 0
Regulation of gap junction activity R-HSA-191650 5.094234e-01 0.293 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.215818e-01 0.654 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.643410e-01 0.248 0 0
HSF1-dependent transactivation R-HSA-3371571 4.015456e-01 0.396 1 1
Role of second messengers in netrin-1 signaling R-HSA-418890 5.660303e-01 0.247 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.735301e-01 0.241 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.776368e-01 0.238 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.776368e-01 0.238 0 0
Signaling by PDGF R-HSA-186797 5.894108e-01 0.230 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.072790e-01 0.512 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.072790e-01 0.512 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.074106e-01 0.512 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.720436e-01 0.326 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.723912e-01 0.326 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.196142e-01 0.495 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.858271e-01 0.232 0 0
Generic Transcription Pathway R-HSA-212436 2.710627e-01 0.567 1 0
Oncogene Induced Senescence R-HSA-2559585 5.569718e-01 0.254 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.858271e-01 0.232 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.513279e-01 0.454 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.045737e-01 0.297 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.456256e-01 0.610 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.406752e-01 0.619 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.280492e-01 0.484 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.234058e-01 0.373 0 0
Killing mechanisms R-HSA-9664420 4.234058e-01 0.373 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.643410e-01 0.248 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.643410e-01 0.248 0 0
Activation of AKT2 R-HSA-165158 5.643410e-01 0.248 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.643410e-01 0.248 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.830288e-01 0.417 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.843873e-01 0.315 0 0
Aggrephagy R-HSA-9646399 4.844862e-01 0.315 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.660303e-01 0.247 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.120208e-01 0.291 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.292541e-01 0.640 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.816697e-01 0.317 0 0
Mismatch Repair R-HSA-5358508 2.923772e-01 0.534 0 0
IGF1R signaling cascade R-HSA-2428924 2.412055e-01 0.618 0 0
DNA Damage Bypass R-HSA-73893 5.148348e-01 0.288 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.498705e-01 0.602 0 0
mTORC1-mediated signalling R-HSA-166208 2.414777e-01 0.617 0 0
Regulation of KIT signaling R-HSA-1433559 3.601338e-01 0.444 0 0
HCMV Infection R-HSA-9609646 5.270735e-01 0.278 0 0
ESR-mediated signaling R-HSA-8939211 2.848962e-01 0.545 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.325943e-01 0.478 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.843873e-01 0.315 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.684889e-01 0.434 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.261768e-01 0.279 0 0
Signaling by WNT R-HSA-195721 5.706866e-01 0.244 1 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.545556e-01 0.594 0 0
Co-inhibition by PD-1 R-HSA-389948 2.387912e-01 0.622 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.773614e-01 0.557 1 0
Autophagy R-HSA-9612973 4.117591e-01 0.385 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.022752e-01 0.694 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.751289e-01 0.426 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.449763e-01 0.462 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.229198e-01 0.374 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.670868e-01 0.435 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.958835e-01 0.225 0 0
HIV Life Cycle R-HSA-162587 2.657260e-01 0.576 0 0
Signaling by WNT in cancer R-HSA-4791275 4.698307e-01 0.328 0 0
Insulin receptor signalling cascade R-HSA-74751 3.526789e-01 0.453 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.923772e-01 0.534 0 0
Signaling by FGFR in disease R-HSA-1226099 2.727444e-01 0.564 0 0
Signal transduction by L1 R-HSA-445144 5.695096e-01 0.244 0 0
G1/S Transition R-HSA-69206 5.935017e-01 0.227 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.200142e-01 0.658 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.832407e-01 0.234 0 0
MAP kinase activation R-HSA-450294 5.733710e-01 0.242 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.307266e-01 0.637 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.281381e-01 0.484 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.221323e-01 0.653 0 0
Macroautophagy R-HSA-1632852 5.079762e-01 0.294 0 0
Opioid Signalling R-HSA-111885 4.980163e-01 0.303 1 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.995651e-01 0.524 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.995651e-01 0.524 0 0
Interleukin-33 signaling R-HSA-9014843 3.779614e-01 0.423 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.779614e-01 0.423 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.475873e-01 0.349 0 0
MET interacts with TNS proteins R-HSA-8875513 4.475873e-01 0.349 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.017472e-01 0.695 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.751289e-01 0.426 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.280492e-01 0.484 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.187700e-01 0.497 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.601338e-01 0.444 0 0
Transmission across Electrical Synapses R-HSA-112307 5.094234e-01 0.293 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.094234e-01 0.293 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.919803e-01 0.407 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.919803e-01 0.407 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.011699e-01 0.397 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.643410e-01 0.248 0 0
Reelin signalling pathway R-HSA-8866376 5.643410e-01 0.248 0 0
PKA activation R-HSA-163615 5.136987e-01 0.289 0 0
PKA activation in glucagon signalling R-HSA-164378 5.136987e-01 0.289 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.142116e-01 0.289 0 0
HIV Infection R-HSA-162906 5.483775e-01 0.261 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.372506e-01 0.472 0 0
Signaling by PTK6 R-HSA-8848021 3.372506e-01 0.472 0 0
Selective autophagy R-HSA-9663891 3.681679e-01 0.434 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.605315e-01 0.584 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.151227e-01 0.667 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.775385e-01 0.321 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.764130e-01 0.322 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.843873e-01 0.315 0 0
FLT3 Signaling R-HSA-9607240 2.151227e-01 0.667 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.892680e-01 0.539 0 0
ERK/MAPK targets R-HSA-198753 3.719341e-01 0.430 0 0
Signal attenuation R-HSA-74749 4.564537e-01 0.341 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.542527e-01 0.343 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.881803e-01 0.311 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.187700e-01 0.497 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.723912e-01 0.326 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.507864e-01 0.346 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.015668e-01 0.300 0 0
Ion homeostasis R-HSA-5578775 4.894187e-01 0.310 1 1
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.986102e-01 0.525 0 0
CHL1 interactions R-HSA-447041 3.325943e-01 0.478 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.325943e-01 0.478 0 0
Signaling by LTK R-HSA-9842663 2.959358e-01 0.529 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.643410e-01 0.248 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.313260e-01 0.275 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.537602e-01 0.451 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.197816e-01 0.658 0 0
Amine ligand-binding receptors R-HSA-375280 5.816801e-01 0.235 0 0
Signaling by NTRKs R-HSA-166520 2.557718e-01 0.592 0 0
Cell-cell junction organization R-HSA-421270 2.166191e-01 0.664 0 0
Adherens junctions interactions R-HSA-418990 2.066846e-01 0.685 0 0
HCMV Late Events R-HSA-9610379 4.220833e-01 0.375 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.021185e-01 0.396 0 0
GPVI-mediated activation cascade R-HSA-114604 4.021236e-01 0.396 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.414777e-01 0.617 0 0
NGF-stimulated transcription R-HSA-9031628 4.964600e-01 0.304 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.200142e-01 0.658 0 0
Signaling by KIT in disease R-HSA-9669938 2.414777e-01 0.617 0 0
Regulation of beta-cell development R-HSA-186712 4.006166e-01 0.397 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.298506e-01 0.276 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.995651e-01 0.524 0 0
Inhibition of membrane repair R-HSA-9635644 2.995651e-01 0.524 0 0
DSCAM interactions R-HSA-376172 3.779614e-01 0.423 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.475873e-01 0.349 0 0
NADE modulates death signalling R-HSA-205025 5.094234e-01 0.293 0 0
Sensory perception of sour taste R-HSA-9729555 5.094234e-01 0.293 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.190452e-01 0.496 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.547845e-01 0.450 0 0
Synthesis of PI R-HSA-1483226 4.947721e-01 0.306 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.947721e-01 0.306 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.643410e-01 0.248 0 0
Interleukin-36 pathway R-HSA-9014826 5.643410e-01 0.248 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.921994e-01 0.308 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.894187e-01 0.310 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.958835e-01 0.225 0 0
Base Excision Repair R-HSA-73884 2.051249e-01 0.688 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.547845e-01 0.450 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.441901e-01 0.612 0 0
Sensory processing of sound R-HSA-9659379 3.404621e-01 0.468 0 0
Signal regulatory protein family interactions R-HSA-391160 3.601338e-01 0.444 0 0
Host Interactions of HIV factors R-HSA-162909 3.759623e-01 0.425 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.892680e-01 0.539 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.892680e-01 0.539 0 0
Cellular responses to stimuli R-HSA-8953897 2.621799e-01 0.581 1 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.843873e-01 0.315 0 0
Cellular responses to stress R-HSA-2262752 3.105413e-01 0.508 1 0
MITF-M-dependent gene expression R-HSA-9856651 2.737411e-01 0.563 0 0
Interleukin-2 family signaling R-HSA-451927 4.844862e-01 0.315 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.456256e-01 0.610 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.456256e-01 0.610 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.779614e-01 0.423 0 0
Signaling by LTK in cancer R-HSA-9842640 2.892680e-01 0.539 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.475873e-01 0.349 0 0
Interleukin-18 signaling R-HSA-9012546 3.751289e-01 0.426 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.165067e-01 0.380 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.094234e-01 0.293 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.074106e-01 0.512 0 0
NrCAM interactions R-HSA-447038 5.643410e-01 0.248 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 5.695096e-01 0.244 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.755961e-01 0.240 0 0
Inositol phosphate metabolism R-HSA-1483249 2.267916e-01 0.644 0 0
Nephron development R-HSA-9831926 2.923772e-01 0.534 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.502887e-01 0.347 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.683782e-01 0.245 0 0
Programmed Cell Death R-HSA-5357801 5.030203e-01 0.298 0 0
Zinc transporters R-HSA-435354 3.601338e-01 0.444 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.190452e-01 0.496 0 0
Glucose metabolism R-HSA-70326 2.203404e-01 0.657 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.142116e-01 0.289 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.601338e-01 0.444 0 0
Interleukin-1 processing R-HSA-448706 4.165067e-01 0.380 0 0
Mitochondrial calcium ion transport R-HSA-8949215 3.984500e-01 0.400 0 0
Interleukin-12 family signaling R-HSA-447115 5.865413e-01 0.232 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.923772e-01 0.534 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.187700e-01 0.497 0 0
Interleukin-15 signaling R-HSA-8983432 5.660303e-01 0.247 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.247682e-01 0.372 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.682066e-01 0.434 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 4.165067e-01 0.380 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.342515e-01 0.630 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.643410e-01 0.248 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.958835e-01 0.225 0 0
Signaling by Leptin R-HSA-2586552 4.564537e-01 0.341 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.858939e-01 0.313 0 0
Interleukin-12 signaling R-HSA-9020591 5.384508e-01 0.269 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.660303e-01 0.247 0 0
Signaling by Erythropoietin R-HSA-9006335 5.961789e-01 0.225 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.961789e-01 0.225 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.961789e-01 0.225 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.961789e-01 0.225 0 0
Signaling by MET R-HSA-6806834 5.966320e-01 0.224 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.988410e-01 0.223 0 0
Frs2-mediated activation R-HSA-170968 5.988410e-01 0.223 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.988410e-01 0.223 0 0
Formation of axial mesoderm R-HSA-9796292 5.988410e-01 0.223 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.988410e-01 0.223 0 0
Interleukin-6 signaling R-HSA-1059683 5.988410e-01 0.223 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.988410e-01 0.223 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.999856e-01 0.222 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.999856e-01 0.222 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 5.999856e-01 0.222 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.024945e-01 0.220 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.051536e-01 0.218 0 0
Vesicle-mediated transport R-HSA-5653656 6.117891e-01 0.213 0 0
Cam-PDE 1 activation R-HSA-111957 6.131136e-01 0.212 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.131136e-01 0.212 0 0
PDE3B signalling R-HSA-165160 6.131136e-01 0.212 0 0
PKB-mediated events R-HSA-109703 6.131136e-01 0.212 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.131136e-01 0.212 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.131136e-01 0.212 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.131136e-01 0.212 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.131136e-01 0.212 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 6.131136e-01 0.212 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.131136e-01 0.212 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.131136e-01 0.212 0 0
Synthesis of PS R-HSA-1483101 6.131136e-01 0.212 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.131136e-01 0.212 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.131136e-01 0.212 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.131136e-01 0.212 0 0
Relaxin receptors R-HSA-444821 6.131136e-01 0.212 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.131136e-01 0.212 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.131136e-01 0.212 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.133854e-01 0.212 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.178509e-01 0.209 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.178509e-01 0.209 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.180934e-01 0.209 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.180934e-01 0.209 0 0
Activation of BH3-only proteins R-HSA-114452 6.180934e-01 0.209 0 0
Interleukin-37 signaling R-HSA-9008059 6.180934e-01 0.209 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.190133e-01 0.208 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.211797e-01 0.207 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.297471e-01 0.201 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.297471e-01 0.201 0 0
Removal of the Flap Intermediate R-HSA-69166 6.297471e-01 0.201 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.297471e-01 0.201 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.297471e-01 0.201 0 0
Nucleotide Excision Repair R-HSA-5696398 6.307997e-01 0.200 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.307997e-01 0.200 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 6.351491e-01 0.197 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.352559e-01 0.197 0 0
Stabilization of p53 R-HSA-69541 6.363839e-01 0.196 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.409225e-01 0.193 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.409225e-01 0.193 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.409225e-01 0.193 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.453727e-01 0.190 0 0
FGFR2 alternative splicing R-HSA-6803529 6.453727e-01 0.190 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.453727e-01 0.190 0 0
LDL clearance R-HSA-8964038 6.453727e-01 0.190 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.453727e-01 0.190 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.511259e-01 0.186 0 0
Generation of second messenger molecules R-HSA-202433 6.548052e-01 0.184 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.555474e-01 0.183 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.564286e-01 0.183 0 0
VLDL assembly R-HSA-8866423 6.564286e-01 0.183 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.564286e-01 0.183 0 0
STAT5 Activation R-HSA-9645135 6.564286e-01 0.183 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.564286e-01 0.183 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.564286e-01 0.183 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.564286e-01 0.183 0 0
Defective CYP11A1 causes AICSR R-HSA-5579026 6.564286e-01 0.183 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.564286e-01 0.183 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.564286e-01 0.183 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.564286e-01 0.183 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.564286e-01 0.183 0 0
Agmatine biosynthesis R-HSA-351143 6.564286e-01 0.183 0 0
Neurofascin interactions R-HSA-447043 6.564286e-01 0.183 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.564286e-01 0.183 0 0
NADPH regeneration R-HSA-389542 6.564286e-01 0.183 0 0
Nef and signal transduction R-HSA-164944 6.564286e-01 0.183 0 0
HDL clearance R-HSA-8964011 6.564286e-01 0.183 0 0
Translesion synthesis by REV1 R-HSA-110312 6.587638e-01 0.181 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.587638e-01 0.181 0 0
Protein methylation R-HSA-8876725 6.587638e-01 0.181 0 0
Other semaphorin interactions R-HSA-416700 6.587638e-01 0.181 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.587638e-01 0.181 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.587638e-01 0.181 0 0
Formation of the anterior neural plate R-HSA-9823739 6.587638e-01 0.181 0 0
DNA Damage Reversal R-HSA-73942 6.587638e-01 0.181 0 0
UCH proteinases R-HSA-5689603 6.642145e-01 0.178 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.643396e-01 0.178 0 0
Signaling by Insulin receptor R-HSA-74752 6.643396e-01 0.178 0 0
Hedgehog 'off' state R-HSA-5610787 6.648734e-01 0.177 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.656226e-01 0.177 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.684495e-01 0.175 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 6.684495e-01 0.175 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.684495e-01 0.175 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.684495e-01 0.175 0 0
Syndecan interactions R-HSA-3000170 6.684495e-01 0.175 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.684495e-01 0.175 0 0
Growth hormone receptor signaling R-HSA-982772 6.684495e-01 0.175 0 0
Degradation of CDH1 R-HSA-9766229 6.686212e-01 0.175 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.726178e-01 0.172 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.768146e-01 0.170 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.788363e-01 0.168 0 0
G-protein beta:gamma signalling R-HSA-397795 6.791994e-01 0.168 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.791994e-01 0.168 0 0
Cardiogenesis R-HSA-9733709 6.791994e-01 0.168 0 0
Translesion synthesis by POLI R-HSA-5656121 6.859268e-01 0.164 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.859268e-01 0.164 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.859268e-01 0.164 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.859268e-01 0.164 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.859268e-01 0.164 0 0
Negative regulation of FLT3 R-HSA-9706369 6.859268e-01 0.164 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.859268e-01 0.164 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.859268e-01 0.164 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.898115e-01 0.161 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.898115e-01 0.161 0 0
Interleukin-6 family signaling R-HSA-6783589 6.904071e-01 0.161 0 0
TNFs bind their physiological receptors R-HSA-5669034 6.904071e-01 0.161 0 0
PCP/CE pathway R-HSA-4086400 6.905210e-01 0.161 0 0
Netrin mediated repulsion signals R-HSA-418886 6.948964e-01 0.158 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.948964e-01 0.158 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.948964e-01 0.158 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.948964e-01 0.158 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.948964e-01 0.158 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.948964e-01 0.158 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.948964e-01 0.158 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.948964e-01 0.158 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.948964e-01 0.158 0 0
PTK6 Expression R-HSA-8849473 6.948964e-01 0.158 0 0
LDL remodeling R-HSA-8964041 6.948964e-01 0.158 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.948964e-01 0.158 0 0
Electron transport from NADPH to Ferredoxin R-HSA-2395516 6.948964e-01 0.158 0 0
Glycoprotein hormones R-HSA-209822 6.948964e-01 0.158 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.948964e-01 0.158 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.948964e-01 0.158 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.948964e-01 0.158 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.948964e-01 0.158 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.979776e-01 0.156 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.058848e-01 0.151 0 0
Interleukin-17 signaling R-HSA-448424 7.058848e-01 0.151 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.063792e-01 0.151 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.063792e-01 0.151 0 0
Signaling by TGFB family members R-HSA-9006936 7.087692e-01 0.149 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.090705e-01 0.149 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.090705e-01 0.149 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.112517e-01 0.148 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.112517e-01 0.148 0 0
Formation of the nephric duct R-HSA-9830364 7.112517e-01 0.148 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 7.112873e-01 0.148 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.112873e-01 0.148 0 0
Translesion synthesis by POLK R-HSA-5655862 7.112873e-01 0.148 0 0
Phase 2 - plateau phase R-HSA-5576893 7.112873e-01 0.148 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.112873e-01 0.148 0 0
Synthesis of PG R-HSA-1483148 7.112873e-01 0.148 0 0
Platelet activation, signaling and aggregation R-HSA-76002 7.125355e-01 0.147 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.148932e-01 0.146 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.148932e-01 0.146 0 0
Orc1 removal from chromatin R-HSA-68949 7.148932e-01 0.146 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.159528e-01 0.145 0 0
Dual Incision in GG-NER R-HSA-5696400 7.159528e-01 0.145 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.159528e-01 0.145 0 0
Mitophagy R-HSA-5205647 7.159528e-01 0.145 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.159528e-01 0.145 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.172975e-01 0.144 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.193690e-01 0.143 0 0
Signaling by NOTCH R-HSA-157118 7.225210e-01 0.141 0 0
Neuronal System R-HSA-112316 7.226520e-01 0.141 1 0
Influenza Infection R-HSA-168255 7.261683e-01 0.139 0 0
Integration of energy metabolism R-HSA-163685 7.266786e-01 0.139 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.290592e-01 0.137 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.290592e-01 0.137 0 0
phospho-PLA2 pathway R-HSA-111995 7.290592e-01 0.137 0 0
MET receptor recycling R-HSA-8875656 7.290592e-01 0.137 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.290592e-01 0.137 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.290592e-01 0.137 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.290592e-01 0.137 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.290592e-01 0.137 0 0
Sodium/Proton exchangers R-HSA-425986 7.290592e-01 0.137 0 0
Interleukin-9 signaling R-HSA-8985947 7.290592e-01 0.137 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.290592e-01 0.137 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.290592e-01 0.137 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.290592e-01 0.137 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.290592e-01 0.137 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.290592e-01 0.137 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.309970e-01 0.136 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.309970e-01 0.136 0 0
Myogenesis R-HSA-525793 7.309970e-01 0.136 0 0
TRP channels R-HSA-3295583 7.309970e-01 0.136 0 0
Downstream TCR signaling R-HSA-202424 7.357493e-01 0.133 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.376267e-01 0.132 0 0
Adaptive Immune System R-HSA-1280218 7.413843e-01 0.130 0 0
Transmission across Chemical Synapses R-HSA-112315 7.428369e-01 0.129 1 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.488636e-01 0.126 0 0
Ion transport by P-type ATPases R-HSA-936837 7.491331e-01 0.125 1 1
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.493165e-01 0.125 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 7.495092e-01 0.125 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.496631e-01 0.125 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.496631e-01 0.125 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.496631e-01 0.125 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.523087e-01 0.124 0 0
Signaling by FGFR3 R-HSA-5654741 7.523087e-01 0.124 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.568616e-01 0.121 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.568616e-01 0.121 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.568616e-01 0.121 0 0
Tie2 Signaling R-HSA-210993 7.568616e-01 0.121 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.572086e-01 0.121 0 0
Developmental Biology R-HSA-1266738 7.572262e-01 0.121 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.576996e-01 0.121 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.593985e-01 0.120 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.593985e-01 0.120 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.593985e-01 0.120 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.593985e-01 0.120 0 0
Interleukin-21 signaling R-HSA-9020958 7.593985e-01 0.120 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.593985e-01 0.120 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.593985e-01 0.120 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.602758e-01 0.119 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.607195e-01 0.119 0 0
Signaling by Interleukins R-HSA-449147 7.610952e-01 0.119 0 0
Degradation of DVL R-HSA-4641258 7.651080e-01 0.116 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.666467e-01 0.115 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.672756e-01 0.115 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.672756e-01 0.115 0 0
TNF signaling R-HSA-75893 7.693485e-01 0.114 0 0
Signaling by FGFR1 R-HSA-5654736 7.693485e-01 0.114 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.715880e-01 0.113 0 0
Specification of the neural plate border R-HSA-9834899 7.772241e-01 0.109 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.772241e-01 0.109 0 0
Regulation of signaling by CBL R-HSA-912631 7.772241e-01 0.109 0 0
Maturation of nucleoprotein R-HSA-9694631 7.772241e-01 0.109 0 0
Other interleukin signaling R-HSA-449836 7.772241e-01 0.109 0 0
The NLRP3 inflammasome R-HSA-844456 7.772241e-01 0.109 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.798149e-01 0.108 0 0
MET promotes cell motility R-HSA-8875878 7.799378e-01 0.108 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.799378e-01 0.108 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.838640e-01 0.106 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.838640e-01 0.106 0 0
Platelet calcium homeostasis R-HSA-418360 7.838640e-01 0.106 0 0
DARPP-32 events R-HSA-180024 7.838640e-01 0.106 0 0
Kidney development R-HSA-9830369 7.846434e-01 0.105 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.863421e-01 0.104 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.863421e-01 0.104 0 0
DNA replication initiation R-HSA-68952 7.863421e-01 0.104 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.863421e-01 0.104 0 0
Arachidonate production from DAG R-HSA-426048 7.863421e-01 0.104 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.863421e-01 0.104 0 0
Interleukin-27 signaling R-HSA-9020956 7.863421e-01 0.104 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.863421e-01 0.104 0 0
Peptide hormone biosynthesis R-HSA-209952 7.863421e-01 0.104 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.863421e-01 0.104 0 0
Intraflagellar transport R-HSA-5620924 7.926559e-01 0.101 0 0
Metal ion SLC transporters R-HSA-425410 7.926559e-01 0.101 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.926559e-01 0.101 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.932719e-01 0.101 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.932719e-01 0.101 0 0
Dual incision in TC-NER R-HSA-6782135 7.934962e-01 0.100 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.940151e-01 0.100 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.940151e-01 0.100 0 0
Signaling by ALK R-HSA-201556 7.940151e-01 0.100 0 0
Transcription of the HIV genome R-HSA-167172 7.956077e-01 0.099 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.956077e-01 0.099 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.960769e-01 0.099 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 7.960769e-01 0.099 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.994617e-01 0.097 0 0
DAP12 signaling R-HSA-2424491 7.994617e-01 0.097 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.994617e-01 0.097 0 0
Extension of Telomeres R-HSA-180786 8.048196e-01 0.094 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.049032e-01 0.094 0 0
Gap junction trafficking and regulation R-HSA-157858 8.049032e-01 0.094 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.054604e-01 0.094 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.073585e-01 0.093 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.073585e-01 0.093 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.073585e-01 0.093 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.073585e-01 0.093 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.083404e-01 0.092 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.102698e-01 0.091 0 0
Chylomicron assembly R-HSA-8963888 8.102698e-01 0.091 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 8.102698e-01 0.091 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.102698e-01 0.091 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.102698e-01 0.091 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.102698e-01 0.091 0 0
LGI-ADAM interactions R-HSA-5682910 8.102698e-01 0.091 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.102698e-01 0.091 0 0
vRNA Synthesis R-HSA-192814 8.102698e-01 0.091 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.102698e-01 0.091 0 0
Bicarbonate transporters R-HSA-425381 8.102698e-01 0.091 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.102698e-01 0.091 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.102698e-01 0.091 0 0
Suppression of apoptosis R-HSA-9635465 8.102698e-01 0.091 0 0
Transport of RCbl within the body R-HSA-9758890 8.102698e-01 0.091 0 0
Interleukin-2 signaling R-HSA-9020558 8.102698e-01 0.091 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.102698e-01 0.091 0 0
Peptide chain elongation R-HSA-156902 8.110915e-01 0.091 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 8.135026e-01 0.090 0 0
Signalling to RAS R-HSA-167044 8.135026e-01 0.090 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.135026e-01 0.090 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.135026e-01 0.090 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.135026e-01 0.090 0 0
Basigin interactions R-HSA-210991 8.135026e-01 0.090 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.135026e-01 0.090 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.141044e-01 0.089 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.141044e-01 0.089 0 0
Budding and maturation of HIV virion R-HSA-162588 8.141044e-01 0.089 0 0
Signaling by ERBB2 R-HSA-1227986 8.156538e-01 0.088 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.162576e-01 0.088 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.165695e-01 0.088 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.170695e-01 0.088 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.170695e-01 0.088 0 0
Signaling by FGFR2 R-HSA-5654738 8.178256e-01 0.087 0 0
PKR-mediated signaling R-HSA-9833482 8.178256e-01 0.087 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.191295e-01 0.087 0 0
PTEN Regulation R-HSA-6807070 8.248917e-01 0.084 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.255234e-01 0.083 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.259566e-01 0.083 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.265418e-01 0.083 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.269454e-01 0.083 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.276689e-01 0.082 0 0
Cardiac conduction R-HSA-5576891 8.281111e-01 0.082 1 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.295844e-01 0.081 0 0
Assembly Of The HIV Virion R-HSA-175474 8.295844e-01 0.081 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.307793e-01 0.081 0 0
Signaling by FGFR R-HSA-190236 8.307793e-01 0.081 0 0
Regulation of insulin secretion R-HSA-422356 8.307793e-01 0.081 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.315191e-01 0.080 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.315191e-01 0.080 0 0
Scavenging by Class H Receptors R-HSA-3000497 8.315191e-01 0.080 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.315191e-01 0.080 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.315191e-01 0.080 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.315191e-01 0.080 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.315191e-01 0.080 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.319279e-01 0.080 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.319279e-01 0.080 0 0
Intra-Golgi traffic R-HSA-6811438 8.319279e-01 0.080 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.319279e-01 0.080 0 0
Mitochondrial protein import R-HSA-1268020 8.358944e-01 0.078 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.358944e-01 0.078 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.406770e-01 0.075 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.407160e-01 0.075 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.430515e-01 0.074 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.430515e-01 0.074 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.444046e-01 0.073 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.444046e-01 0.073 0 0
Mitochondrial biogenesis R-HSA-1592230 8.499209e-01 0.071 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.503896e-01 0.070 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.503896e-01 0.070 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.503896e-01 0.070 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.503896e-01 0.070 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.503896e-01 0.070 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.503896e-01 0.070 0 0
Regulation of IFNG signaling R-HSA-877312 8.503896e-01 0.070 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.503896e-01 0.070 0 0
Interleukin-35 Signalling R-HSA-8984722 8.503896e-01 0.070 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.503896e-01 0.070 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.503896e-01 0.070 0 0
Estrogen biosynthesis R-HSA-193144 8.503896e-01 0.070 0 0
OAS antiviral response R-HSA-8983711 8.503896e-01 0.070 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.524137e-01 0.069 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.526859e-01 0.069 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.526859e-01 0.069 0 0
Interleukin-1 signaling R-HSA-9020702 8.534888e-01 0.069 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.534888e-01 0.069 0 0
Interleukin-1 family signaling R-HSA-446652 8.536593e-01 0.069 0 0
Developmental Cell Lineages R-HSA-9734767 8.563973e-01 0.067 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.580441e-01 0.066 0 0
Carnitine shuttle R-HSA-200425 8.580441e-01 0.066 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.607715e-01 0.065 0 0
Interferon Signaling R-HSA-913531 8.630971e-01 0.064 1 0
G1 Phase R-HSA-69236 8.638367e-01 0.064 0 0
Cyclin D associated events in G1 R-HSA-69231 8.638367e-01 0.064 0 0
Gap junction trafficking R-HSA-190828 8.638367e-01 0.064 0 0
RMTs methylate histone arginines R-HSA-3214858 8.638367e-01 0.064 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.638966e-01 0.064 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.638966e-01 0.064 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.638966e-01 0.064 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.671475e-01 0.062 0 0
Chylomicron remodeling R-HSA-8963901 8.671475e-01 0.062 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.671475e-01 0.062 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.671475e-01 0.062 0 0
Maturation of nucleoprotein R-HSA-9683610 8.671475e-01 0.062 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.671475e-01 0.062 0 0
Processing of SMDT1 R-HSA-8949664 8.671475e-01 0.062 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.671475e-01 0.062 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.671475e-01 0.062 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.671475e-01 0.062 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.672989e-01 0.062 0 0
Neutrophil degranulation R-HSA-6798695 8.675094e-01 0.062 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.705813e-01 0.060 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.705813e-01 0.060 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.705813e-01 0.060 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.705813e-01 0.060 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.705813e-01 0.060 0 0
Complex III assembly R-HSA-9865881 8.705813e-01 0.060 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.732528e-01 0.059 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.737187e-01 0.059 0 0
Phospholipid metabolism R-HSA-1483257 8.741928e-01 0.058 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.743495e-01 0.058 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.743495e-01 0.058 0 0
Regulation of Apoptosis R-HSA-169911 8.743495e-01 0.058 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.743495e-01 0.058 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.752193e-01 0.058 0 0
Signaling by Hedgehog R-HSA-5358351 8.775931e-01 0.057 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.802039e-01 0.055 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.820292e-01 0.055 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.820292e-01 0.055 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.820292e-01 0.055 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.820292e-01 0.055 0 0
Hydrolysis of LPC R-HSA-1483115 8.820292e-01 0.055 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.820292e-01 0.055 0 0
cGMP effects R-HSA-418457 8.820292e-01 0.055 0 0
Physiological factors R-HSA-5578768 8.820292e-01 0.055 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.820292e-01 0.055 0 0
HDL assembly R-HSA-8963896 8.820292e-01 0.055 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.820292e-01 0.055 0 0
TGFBR3 expression R-HSA-9839394 8.820921e-01 0.054 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.820921e-01 0.054 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.820921e-01 0.054 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.820921e-01 0.054 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.821009e-01 0.054 0 0
G1/S-Specific Transcription R-HSA-69205 8.840844e-01 0.054 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.864135e-01 0.052 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.864135e-01 0.052 0 0
Parasite infection R-HSA-9664407 8.880046e-01 0.052 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.880046e-01 0.052 0 0
Leishmania phagocytosis R-HSA-9664417 8.880046e-01 0.052 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.904067e-01 0.050 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.904067e-01 0.050 0 0
Platelet homeostasis R-HSA-418346 8.916336e-01 0.050 0 0
Metalloprotease DUBs R-HSA-5689901 8.926489e-01 0.049 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 8.926489e-01 0.049 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.926489e-01 0.049 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.926489e-01 0.049 0 0
Sphingolipid catabolism R-HSA-9845614 8.926489e-01 0.049 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.929360e-01 0.049 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.931404e-01 0.049 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.931404e-01 0.049 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.931404e-01 0.049 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.952447e-01 0.048 0 0
Erythropoietin activates RAS R-HSA-9027284 8.952447e-01 0.048 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.952447e-01 0.048 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.952447e-01 0.048 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.952447e-01 0.048 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.952447e-01 0.048 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.952447e-01 0.048 0 0
p38MAPK events R-HSA-171007 8.952447e-01 0.048 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.952447e-01 0.048 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.952447e-01 0.048 0 0
Protein lipoylation R-HSA-9857492 8.952447e-01 0.048 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.952447e-01 0.048 0 0
tRNA processing R-HSA-72306 9.005565e-01 0.045 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.015560e-01 0.045 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.023211e-01 0.045 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.023211e-01 0.045 0 0
Signaling by BMP R-HSA-201451 9.023211e-01 0.045 0 0
Cristae formation R-HSA-8949613 9.023211e-01 0.045 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.023211e-01 0.045 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.023211e-01 0.045 0 0
Stimuli-sensing channels R-HSA-2672351 9.023696e-01 0.045 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.047701e-01 0.043 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.047701e-01 0.043 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.047701e-01 0.043 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.047701e-01 0.043 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.047701e-01 0.043 0 0
Kinesins R-HSA-983189 9.047701e-01 0.043 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.052372e-01 0.043 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.069805e-01 0.042 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.069805e-01 0.042 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.069805e-01 0.042 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.069805e-01 0.042 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 9.069805e-01 0.042 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.069805e-01 0.042 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.069805e-01 0.042 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.069805e-01 0.042 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.070993e-01 0.042 1 0
Platelet degranulation R-HSA-114608 9.108855e-01 0.041 0 0
Telomere Extension By Telomerase R-HSA-171319 9.111742e-01 0.040 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.111742e-01 0.040 0 0
Inflammasomes R-HSA-622312 9.111742e-01 0.040 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.149803e-01 0.039 1 0
Glycogen metabolism R-HSA-8982491 9.166139e-01 0.038 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.166139e-01 0.038 0 0
Diseases of Immune System R-HSA-5260271 9.166139e-01 0.038 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.174021e-01 0.037 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.174021e-01 0.037 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.174021e-01 0.037 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.174021e-01 0.037 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 9.174021e-01 0.037 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.174021e-01 0.037 0 0
Coenzyme A biosynthesis R-HSA-196783 9.174021e-01 0.037 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.174021e-01 0.037 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.187071e-01 0.037 0 0
mRNA Capping R-HSA-72086 9.192704e-01 0.037 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.192704e-01 0.037 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.192704e-01 0.037 0 0
Signaling by NOTCH4 R-HSA-9013694 9.225582e-01 0.035 0 0
SLC transporter disorders R-HSA-5619102 9.229588e-01 0.035 0 0
Maturation of spike protein R-HSA-9694548 9.233273e-01 0.035 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.241696e-01 0.034 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.246731e-01 0.034 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.266566e-01 0.033 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.266566e-01 0.033 0 0
Glycogen storage diseases R-HSA-3229121 9.266566e-01 0.033 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.266566e-01 0.033 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.266566e-01 0.033 0 0
Choline catabolism R-HSA-6798163 9.266566e-01 0.033 0 0
Uptake and function of anthrax toxins R-HSA-5210891 9.266566e-01 0.033 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.266681e-01 0.033 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.266681e-01 0.033 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.266681e-01 0.033 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.295422e-01 0.032 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.302422e-01 0.031 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.302422e-01 0.031 0 0
Adipogenesis R-HSA-9843745 9.308429e-01 0.031 0 0
MHC class II antigen presentation R-HSA-2132295 9.318176e-01 0.031 0 0
Signaling by NOTCH1 R-HSA-1980143 9.322141e-01 0.030 0 0
Potential therapeutics for SARS R-HSA-9679191 9.331535e-01 0.030 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.331863e-01 0.030 0 0
Ion channel transport R-HSA-983712 9.332213e-01 0.030 1 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.334221e-01 0.030 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.334221e-01 0.030 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.334221e-01 0.030 0 0
Eukaryotic Translation Termination R-HSA-72764 9.335509e-01 0.030 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.348747e-01 0.029 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.348747e-01 0.029 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.348747e-01 0.029 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.348747e-01 0.029 0 0
Apoptotic factor-mediated response R-HSA-111471 9.348747e-01 0.029 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.348747e-01 0.029 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.352905e-01 0.029 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 9.352905e-01 0.029 0 0
Translation initiation complex formation R-HSA-72649 9.354363e-01 0.029 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.359228e-01 0.029 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.363568e-01 0.029 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.366968e-01 0.028 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.374720e-01 0.028 0 0
Toll-like Receptor Cascades R-HSA-168898 9.389219e-01 0.027 0 0
DAG1 glycosylations R-HSA-8931838 9.395838e-01 0.027 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.395838e-01 0.027 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.406031e-01 0.027 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.406031e-01 0.027 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.407887e-01 0.027 0 0
Integrin cell surface interactions R-HSA-216083 9.407887e-01 0.027 0 0
Interleukin-10 signaling R-HSA-6783783 9.407887e-01 0.027 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.417629e-01 0.026 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.421724e-01 0.026 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.421724e-01 0.026 0 0
Diseases of hemostasis R-HSA-9671793 9.421724e-01 0.026 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.421724e-01 0.026 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.422199e-01 0.026 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.447846e-01 0.025 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.452011e-01 0.024 0 0
Proteasome assembly R-HSA-9907900 9.455089e-01 0.024 0 0
DAP12 interactions R-HSA-2172127 9.455089e-01 0.024 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.486527e-01 0.023 0 0
Glycogen synthesis R-HSA-3322077 9.486527e-01 0.023 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.486527e-01 0.023 0 0
Pregnenolone biosynthesis R-HSA-196108 9.486527e-01 0.023 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.486527e-01 0.023 0 0
Creatine metabolism R-HSA-71288 9.486527e-01 0.023 0 0
Formation of definitive endoderm R-HSA-9823730 9.486527e-01 0.023 0 0
Protein hydroxylation R-HSA-9629569 9.486527e-01 0.023 0 0
Signaling by NODAL R-HSA-1181150 9.486527e-01 0.023 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.500358e-01 0.022 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.500358e-01 0.022 0 0
Somitogenesis R-HSA-9824272 9.500358e-01 0.022 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.500358e-01 0.022 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.503186e-01 0.022 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.503186e-01 0.022 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.503186e-01 0.022 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.503186e-01 0.022 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.528792e-01 0.021 0 0
COPII-mediated vesicle transport R-HSA-204005 9.534703e-01 0.021 0 0
Selenocysteine synthesis R-HSA-2408557 9.541783e-01 0.020 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.544072e-01 0.020 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.544072e-01 0.020 0 0
G-protein activation R-HSA-202040 9.544072e-01 0.020 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.544072e-01 0.020 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.544072e-01 0.020 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.544072e-01 0.020 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.544072e-01 0.020 0 0
Ribosome-associated quality control R-HSA-9948299 9.548173e-01 0.020 0 0
Signaling by NOTCH2 R-HSA-1980145 9.549777e-01 0.020 0 0
eNOS activation R-HSA-203615 9.549777e-01 0.020 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.549777e-01 0.020 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.549777e-01 0.020 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.549777e-01 0.020 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.549777e-01 0.020 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.549777e-01 0.020 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.553063e-01 0.020 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.559803e-01 0.020 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.565032e-01 0.019 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.565032e-01 0.019 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.568101e-01 0.019 0 0
Hedgehog 'on' state R-HSA-5632684 9.568101e-01 0.019 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.568101e-01 0.019 0 0
Protein folding R-HSA-391251 9.572440e-01 0.019 0 0
Interferon gamma signaling R-HSA-877300 9.575645e-01 0.019 1 1
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.581364e-01 0.019 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.592169e-01 0.018 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.592169e-01 0.018 0 0
PERK regulates gene expression R-HSA-381042 9.592169e-01 0.018 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.595171e-01 0.018 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.595171e-01 0.018 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.595171e-01 0.018 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.595171e-01 0.018 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.595171e-01 0.018 0 0
Glutathione synthesis and recycling R-HSA-174403 9.595171e-01 0.018 0 0
Viral mRNA Translation R-HSA-192823 9.596586e-01 0.018 0 0
GPER1 signaling R-HSA-9634597 9.615973e-01 0.017 0 0
Gluconeogenesis R-HSA-70263 9.615973e-01 0.017 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.621715e-01 0.017 0 0
Ca2+ pathway R-HSA-4086398 9.628408e-01 0.016 1 1
Formation of paraxial mesoderm R-HSA-9793380 9.629906e-01 0.016 0 0
Aquaporin-mediated transport R-HSA-445717 9.629906e-01 0.016 0 0
HSF1 activation R-HSA-3371511 9.630717e-01 0.016 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.630717e-01 0.016 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.630717e-01 0.016 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.640545e-01 0.016 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.640545e-01 0.016 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.640545e-01 0.016 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.640545e-01 0.016 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.640545e-01 0.016 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.640545e-01 0.016 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.640545e-01 0.016 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.646663e-01 0.016 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.648561e-01 0.016 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.650732e-01 0.015 0 0
Signaling by ERBB4 R-HSA-1236394 9.655566e-01 0.015 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.658862e-01 0.015 0 0
Voltage gated Potassium channels R-HSA-1296072 9.665751e-01 0.015 0 0
Degradation of AXIN R-HSA-4641257 9.665751e-01 0.015 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.665751e-01 0.015 0 0
NCAM1 interactions R-HSA-419037 9.665751e-01 0.015 0 0
Collagen chain trimerization R-HSA-8948216 9.665751e-01 0.015 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.680836e-01 0.014 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.680836e-01 0.014 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.680836e-01 0.014 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.680836e-01 0.014 0 0
Interleukin-20 family signaling R-HSA-8854691 9.680836e-01 0.014 0 0
Formation of the ureteric bud R-HSA-9830674 9.680836e-01 0.014 0 0
Biosynthesis of maresins R-HSA-9018682 9.680836e-01 0.014 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.710549e-01 0.013 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.716613e-01 0.012 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.716613e-01 0.012 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.716613e-01 0.012 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.716613e-01 0.012 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.726433e-01 0.012 0 0
Translation of Structural Proteins R-HSA-9694635 9.726433e-01 0.012 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.726463e-01 0.012 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.748381e-01 0.011 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.748381e-01 0.011 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.748381e-01 0.011 0 0
Laminin interactions R-HSA-3000157 9.748381e-01 0.011 0 0
Attenuation phase R-HSA-3371568 9.752679e-01 0.011 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.752679e-01 0.011 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.752679e-01 0.011 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.752679e-01 0.011 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.774512e-01 0.010 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.775892e-01 0.010 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.776457e-01 0.010 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.776457e-01 0.010 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.776457e-01 0.010 0 0
MET activates PTK2 signaling R-HSA-8874081 9.776590e-01 0.010 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.776590e-01 0.010 0 0
Urea cycle R-HSA-70635 9.776590e-01 0.010 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.776590e-01 0.010 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.776590e-01 0.010 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.776590e-01 0.010 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.789924e-01 0.009 0 0
Signaling by NOTCH3 R-HSA-9012852 9.795428e-01 0.009 0 0
Paracetamol ADME R-HSA-9753281 9.795428e-01 0.009 0 0
G alpha (z) signalling events R-HSA-418597 9.795428e-01 0.009 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.801638e-01 0.009 0 0
Insulin processing R-HSA-264876 9.801638e-01 0.009 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.812220e-01 0.008 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.812220e-01 0.008 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.813333e-01 0.008 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.823878e-01 0.008 0 0
Insulin receptor recycling R-HSA-77387 9.823878e-01 0.008 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.823878e-01 0.008 0 0
Pyroptosis R-HSA-5620971 9.823878e-01 0.008 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.825841e-01 0.008 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.829364e-01 0.007 0 0
Synthesis of PA R-HSA-1483166 9.829734e-01 0.007 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.830690e-01 0.007 0 0
Collagen formation R-HSA-1474290 9.838534e-01 0.007 0 0
RSV-host interactions R-HSA-9833110 9.838738e-01 0.007 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.843627e-01 0.007 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.844750e-01 0.007 0 0
Parasitic Infection Pathways R-HSA-9824443 9.850335e-01 0.007 0 0
Leishmania infection R-HSA-9658195 9.850335e-01 0.007 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.851265e-01 0.007 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.861162e-01 0.006 0 0
Neurotransmitter clearance R-HSA-112311 9.861162e-01 0.006 0 0
Cellular response to starvation R-HSA-9711097 9.866970e-01 0.006 0 0
rRNA processing R-HSA-72312 9.870669e-01 0.006 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.870823e-01 0.006 0 0
tRNA Aminoacylation R-HSA-379724 9.871063e-01 0.006 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.871063e-01 0.006 0 0
Metabolism of polyamines R-HSA-351202 9.871063e-01 0.006 0 0
Cargo concentration in the ER R-HSA-5694530 9.876731e-01 0.005 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.876731e-01 0.005 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.876731e-01 0.005 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.878888e-01 0.005 0 0
Signaling by TGFBR3 R-HSA-9839373 9.878888e-01 0.005 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.878888e-01 0.005 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.878888e-01 0.005 0 0
Collagen degradation R-HSA-1442490 9.882557e-01 0.005 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.886145e-01 0.005 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.890556e-01 0.005 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.901484e-01 0.004 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.902657e-01 0.004 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.902830e-01 0.004 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.902830e-01 0.004 0 0
ER-Phagosome pathway R-HSA-1236974 9.903304e-01 0.004 0 0
Neurotransmitter release cycle R-HSA-112310 9.910965e-01 0.004 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.912900e-01 0.004 0 0
Heme degradation R-HSA-189483 9.913729e-01 0.004 0 0
SARS-CoV Infections R-HSA-9679506 9.922259e-01 0.003 0 0
RA biosynthesis pathway R-HSA-5365859 9.923406e-01 0.003 0 0
Gap junction assembly R-HSA-190861 9.923406e-01 0.003 0 0
Signal amplification R-HSA-392518 9.923406e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.926717e-01 0.003 0 0
Neddylation R-HSA-8951664 9.926903e-01 0.003 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.927860e-01 0.003 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.927860e-01 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.931998e-01 0.003 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.935007e-01 0.003 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.938616e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.938809e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.939443e-01 0.003 0 0
Triglyceride catabolism R-HSA-163560 9.939626e-01 0.003 0 0
Mitochondrial protein degradation R-HSA-9837999 9.941356e-01 0.003 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.942722e-01 0.002 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.946400e-01 0.002 0 0
Lysine catabolism R-HSA-71064 9.946400e-01 0.002 0 0
Metabolism of folate and pterines R-HSA-196757 9.946400e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.950015e-01 0.002 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.952413e-01 0.002 0 0
Elastic fibre formation R-HSA-1566948 9.952413e-01 0.002 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.952413e-01 0.002 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.954084e-01 0.002 0 0
Retinoid metabolism and transport R-HSA-975634 9.954606e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.954606e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.957752e-01 0.002 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.957752e-01 0.002 0 0
G alpha (q) signalling events R-HSA-416476 9.959480e-01 0.002 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.962493e-01 0.002 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.962493e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.966052e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.966702e-01 0.001 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.966702e-01 0.001 0 0
Cellular response to chemical stress R-HSA-9711123 9.967709e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.967727e-01 0.001 0 0
GPCR downstream signalling R-HSA-388396 9.968350e-01 0.001 1 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.970439e-01 0.001 0 0
HIV Transcription Initiation R-HSA-167161 9.970439e-01 0.001 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.970439e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.970439e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9683701 9.970439e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.973756e-01 0.001 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.976702e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.977035e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.977035e-01 0.001 0 0
Gastrulation R-HSA-9758941 9.977502e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.978122e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.979317e-01 0.001 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.981638e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.982911e-01 0.001 0 0
Protein localization R-HSA-9609507 9.983352e-01 0.001 0 0
Cellular response to hypoxia R-HSA-1234174 9.983557e-01 0.001 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.983699e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.985699e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.986726e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.987018e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.987727e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.988076e-01 0.001 0 0
Regulated Necrosis R-HSA-5218859 9.988076e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.989221e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.989791e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.989818e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.989877e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.991013e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.991364e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.992866e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.992918e-01 0.000 0 0
Hemostasis R-HSA-109582 9.993120e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.993809e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.994394e-01 0.000 0 0
Immune System R-HSA-168256 9.994531e-01 0.000 1 0
Dectin-2 family R-HSA-5621480 9.995603e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.995773e-01 0.000 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.996097e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.996535e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.996535e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.996775e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.996925e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.996925e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.996925e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.997270e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.997366e-01 0.000 1 0
Viral Infection Pathways R-HSA-9824446 9.997712e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.997849e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.998642e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.998665e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998870e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999171e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999347e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999359e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999517e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999596e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999640e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999681e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999710e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999714e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999749e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999768e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999824e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999848e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999877e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999923e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999924e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999924e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999939e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999956e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999957e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999971e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999977e-01 0.000 0 0
Translation R-HSA-72766 9.999982e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999984e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999984e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999985e-01 0.000 1 0
Innate Immune System R-HSA-168249 9.999986e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999987e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999990e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999994e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999995e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999995e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999995e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999996e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999997e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999998e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 1 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 1 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 7.165379e-13 12.145 0 0
Cell Cycle, Mitotic R-HSA-69278 2.781442e-12 11.556 0 0
Cell Cycle Checkpoints R-HSA-69620 1.593714e-11 10.798 0 0
M Phase R-HSA-68886 2.687606e-11 10.571 0 0
Apoptotic execution phase R-HSA-75153 1.889240e-10 9.724 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.279274e-08 7.642 0 0
Metabolism of RNA R-HSA-8953854 2.446160e-08 7.612 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.409196e-07 6.851 0 0
Mitotic Prometaphase R-HSA-68877 2.131436e-07 6.671 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.437248e-07 6.613 0 0
G2/M Checkpoints R-HSA-69481 4.180856e-07 6.379 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.702282e-07 6.328 0 0
Apoptosis R-HSA-109581 4.975071e-07 6.303 0 0
Mitotic Prophase R-HSA-68875 8.031995e-07 6.095 0 0
Mitotic Anaphase R-HSA-68882 8.522179e-07 6.069 0 0
mRNA Splicing R-HSA-72172 9.942710e-07 6.002 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 9.600446e-07 6.018 0 0
Muscle contraction R-HSA-397014 1.171256e-06 5.931 1 0
Cell-Cell communication R-HSA-1500931 1.250804e-06 5.903 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.809387e-06 5.742 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.067954e-06 5.684 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.771774e-06 5.557 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.591455e-06 5.586 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.591455e-06 5.586 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.740330e-06 5.562 0 0
Cellular Senescence R-HSA-2559583 2.660373e-06 5.575 0 0
Signal Transduction R-HSA-162582 2.924912e-06 5.534 1 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.787855e-06 5.422 0 0
Nucleosome assembly R-HSA-774815 3.787855e-06 5.422 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.643442e-06 5.438 0 0
Separation of Sister Chromatids R-HSA-2467813 3.706996e-06 5.431 0 0
DNA Double Strand Break Response R-HSA-5693606 4.953155e-06 5.305 0 0
Striated Muscle Contraction R-HSA-390522 5.702210e-06 5.244 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.716437e-06 5.243 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.716437e-06 5.243 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 6.141885e-06 5.212 0 0
Cellular response to heat stress R-HSA-3371556 6.352211e-06 5.197 1 0
Mitotic Spindle Checkpoint R-HSA-69618 6.741183e-06 5.171 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.703936e-06 5.174 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.291291e-06 5.137 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.710491e-06 5.113 0 0
Smooth Muscle Contraction R-HSA-445355 7.779190e-06 5.109 0 0
Cell junction organization R-HSA-446728 7.615481e-06 5.118 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 8.130632e-06 5.090 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.660986e-06 5.062 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.041447e-05 4.982 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.575766e-05 4.803 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.647530e-05 4.783 0 0
Axon guidance R-HSA-422475 1.926140e-05 4.715 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.095440e-05 4.679 1 0
Meiotic synapsis R-HSA-1221632 2.580894e-05 4.588 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.580894e-05 4.588 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.504258e-05 4.601 0 0
Homology Directed Repair R-HSA-5693538 2.516628e-05 4.599 0 0
Chromatin organization R-HSA-4839726 2.801853e-05 4.553 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.129428e-05 4.505 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.325358e-05 4.478 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.534412e-05 4.452 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.569312e-05 4.447 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.789209e-05 4.421 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.112876e-05 4.386 0 0
Nervous system development R-HSA-9675108 4.356068e-05 4.361 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.743732e-05 4.324 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.743732e-05 4.324 0 0
Chromatin modifying enzymes R-HSA-3247509 5.125600e-05 4.290 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.158191e-05 4.288 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.495062e-05 4.260 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.338784e-05 4.198 1 1
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.374717e-05 4.196 0 0
Protein ubiquitination R-HSA-8852135 6.718291e-05 4.173 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.722148e-05 4.172 1 1
Apoptosis induced DNA fragmentation R-HSA-140342 7.079358e-05 4.150 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.854756e-05 4.105 0 0
Adherens junctions interactions R-HSA-418990 8.547796e-05 4.068 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.856226e-05 4.053 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 9.132507e-05 4.039 1 1
Programmed Cell Death R-HSA-5357801 9.652062e-05 4.015 0 0
Signaling by Hippo R-HSA-2028269 1.126684e-04 3.948 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.089911e-04 3.963 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.074349e-04 3.969 0 0
G2/M Transition R-HSA-69275 1.090164e-04 3.963 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.107516e-04 3.956 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.054724e-04 3.977 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.105962e-04 3.956 0 0
Cellular responses to stimuli R-HSA-8953897 1.269838e-04 3.896 1 0
Mitotic G2-G2/M phases R-HSA-453274 1.327226e-04 3.877 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.488769e-04 3.827 0 0
Signaling by ROBO receptors R-HSA-376176 1.426311e-04 3.846 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.598023e-04 3.796 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.810000e-04 3.742 0 0
Regulation of CDH1 Function R-HSA-9764561 1.759481e-04 3.755 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.759481e-04 3.755 0 0
Membrane Trafficking R-HSA-199991 1.778871e-04 3.750 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.755497e-04 3.756 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.885892e-04 3.724 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.885892e-04 3.724 1 1
Signaling downstream of RAS mutants R-HSA-9649948 1.885892e-04 3.724 1 1
Condensation of Prophase Chromosomes R-HSA-2299718 1.885892e-04 3.724 0 0
Signaling by RAS mutants R-HSA-6802949 1.885892e-04 3.724 1 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.928898e-04 3.715 0 0
mRNA 3'-end processing R-HSA-72187 2.024165e-04 3.694 0 0
Cell-cell junction organization R-HSA-421270 2.241531e-04 3.649 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.295162e-04 3.639 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.446478e-04 3.611 0 0
RNA Polymerase I Transcription R-HSA-73864 2.878832e-04 3.541 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.729860e-04 3.564 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.201954e-04 3.495 1 0
Meiosis R-HSA-1500620 3.201954e-04 3.495 0 0
DNA methylation R-HSA-5334118 3.257043e-04 3.487 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.257043e-04 3.487 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.275313e-04 3.485 0 0
HDACs deacetylate histones R-HSA-3214815 3.510531e-04 3.455 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.550614e-04 3.450 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.489648e-04 3.457 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.558050e-04 3.449 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.622972e-04 3.441 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.663790e-04 3.436 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.136201e-04 3.383 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.386066e-04 3.358 0 0
HSF1-dependent transactivation R-HSA-3371571 4.894737e-04 3.310 1 1
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.027542e-04 3.299 0 0
Cellular responses to stress R-HSA-2262752 5.211116e-04 3.283 1 0
Eukaryotic Translation Initiation R-HSA-72613 5.383286e-04 3.269 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.383286e-04 3.269 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.398289e-04 3.268 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.478990e-04 3.261 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.572126e-04 3.254 1 1
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.153710e-04 3.211 0 0
Glycolysis R-HSA-70171 6.196534e-04 3.208 0 0
Regulation of PTEN localization R-HSA-8948747 6.406635e-04 3.193 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.427893e-04 3.192 0 0
Packaging Of Telomere Ends R-HSA-171306 7.126090e-04 3.147 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.431311e-04 3.129 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.880672e-04 3.103 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 8.194274e-04 3.086 1 0
Cell-extracellular matrix interactions R-HSA-446353 8.686591e-04 3.061 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.699659e-04 3.060 0 0
Defective pyroptosis R-HSA-9710421 9.536059e-04 3.021 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.042471e-03 2.982 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.042471e-03 2.982 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.042471e-03 2.982 0 0
Regulation of TP53 Activity R-HSA-5633007 9.652745e-04 3.015 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.100098e-03 2.959 0 0
Late endosomal microautophagy R-HSA-9615710 1.136715e-03 2.944 0 0
Centrosome maturation R-HSA-380287 1.147989e-03 2.940 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.151029e-03 2.939 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.225469e-03 2.912 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.332606e-03 2.875 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.262473e-03 2.899 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.262473e-03 2.899 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.255439e-03 2.901 0 0
Meiotic recombination R-HSA-912446 1.355182e-03 2.868 0 0
ESR-mediated signaling R-HSA-8939211 1.370834e-03 2.863 0 0
Diseases of programmed cell death R-HSA-9645723 1.287553e-03 2.890 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.398059e-03 2.854 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.550924e-03 2.809 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.590815e-03 2.798 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.599722e-03 2.796 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.599722e-03 2.796 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.863823e-03 2.730 0 0
Chromosome Maintenance R-HSA-73886 1.903860e-03 2.720 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.948629e-03 2.710 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.955007e-03 2.709 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.032272e-03 2.692 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.102738e-03 2.677 1 1
Opioid Signalling R-HSA-111885 2.126058e-03 2.672 1 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.144716e-03 2.669 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.151491e-03 2.667 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.397527e-03 2.620 0 0
Josephin domain DUBs R-HSA-5689877 2.397527e-03 2.620 0 0
Translation initiation complex formation R-HSA-72649 2.165577e-03 2.664 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.397527e-03 2.620 1 1
Eukaryotic Translation Elongation R-HSA-156842 2.320425e-03 2.634 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.397527e-03 2.620 0 0
Amyloid fiber formation R-HSA-977225 2.476498e-03 2.606 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.497700e-03 2.602 0 0
Post NMDA receptor activation events R-HSA-438064 2.548684e-03 2.594 1 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.609092e-03 2.584 0 0
HIV Life Cycle R-HSA-162587 2.647453e-03 2.577 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.781977e-03 2.556 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.857369e-03 2.544 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.903055e-03 2.537 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.132732e-03 2.504 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.132732e-03 2.504 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.151429e-03 2.501 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.437097e-03 2.464 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.586229e-03 2.445 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.193334e-03 2.496 0 0
Signaling by WNT R-HSA-195721 3.392125e-03 2.470 1 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.211114e-03 2.493 0 0
Signaling by ALK in cancer R-HSA-9700206 3.211114e-03 2.493 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.353299e-03 2.475 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.727325e-03 2.429 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.780770e-03 2.422 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.836058e-03 2.416 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.066843e-03 2.391 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.202078e-03 2.377 0 0
Metabolism of non-coding RNA R-HSA-194441 4.387090e-03 2.358 0 0
snRNP Assembly R-HSA-191859 4.387090e-03 2.358 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.423039e-03 2.354 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.444352e-03 2.352 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.506631e-03 2.346 0 0
Oncogene Induced Senescence R-HSA-2559585 4.506631e-03 2.346 0 0
Deubiquitination R-HSA-5688426 4.521595e-03 2.345 0 0
L1CAM interactions R-HSA-373760 4.624712e-03 2.335 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.779414e-03 2.321 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.125474e-03 2.290 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.125474e-03 2.290 0 0
Long-term potentiation R-HSA-9620244 5.125474e-03 2.290 1 1
Recycling pathway of L1 R-HSA-437239 4.976185e-03 2.303 0 0
CaM pathway R-HSA-111997 5.338966e-03 2.273 1 0
Calmodulin induced events R-HSA-111933 5.338966e-03 2.273 1 0
G-protein mediated events R-HSA-112040 5.217730e-03 2.283 1 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.779414e-03 2.321 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.202418e-03 2.284 1 1
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.110901e-03 2.292 0 0
Signaling by NOTCH R-HSA-157118 4.761864e-03 2.322 0 0
Glucose metabolism R-HSA-70326 5.062638e-03 2.296 0 0
Ub-specific processing proteases R-HSA-5689880 5.496321e-03 2.260 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.553801e-03 2.255 0 0
PLC beta mediated events R-HSA-112043 5.682456e-03 2.245 1 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.779187e-03 2.238 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 5.779187e-03 2.238 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.797838e-03 2.237 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.867587e-03 2.232 0 0
Ca-dependent events R-HSA-111996 6.059960e-03 2.218 1 0
Peptide chain elongation R-HSA-156902 6.061275e-03 2.217 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.061815e-03 2.217 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.061815e-03 2.217 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.288121e-03 2.201 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.288121e-03 2.201 0 0
Cleavage of the damaged purine R-HSA-110331 6.288121e-03 2.201 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.327342e-03 2.199 0 0
DNA Replication R-HSA-69306 6.331313e-03 2.199 0 0
Gene Silencing by RNA R-HSA-211000 6.386116e-03 2.195 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.189933e-03 2.143 1 1
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.189933e-03 2.143 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.549330e-03 2.122 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.170422e-03 2.144 1 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.426964e-03 2.129 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.471954e-03 2.189 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.025683e-03 2.153 0 0
Ion homeostasis R-HSA-5578775 7.004159e-03 2.155 1 1
Semaphorin interactions R-HSA-373755 7.270101e-03 2.138 0 0
Death Receptor Signaling R-HSA-73887 6.825131e-03 2.166 0 0
NRAGE signals death through JNK R-HSA-193648 7.004159e-03 2.155 0 0
Assembly Of The HIV Virion R-HSA-175474 7.189933e-03 2.143 0 0
Depurination R-HSA-73927 7.364782e-03 2.133 0 0
Interleukin-12 signaling R-HSA-9020591 6.718086e-03 2.173 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.567504e-03 2.121 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.085760e-03 2.092 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.227221e-03 2.085 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.311676e-03 2.080 0 0
G alpha (12/13) signalling events R-HSA-416482 8.343264e-03 2.079 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.562166e-03 2.067 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.820182e-03 2.055 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.839122e-03 2.054 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.923555e-03 2.049 0 0
DAG and IP3 signaling R-HSA-1489509 9.317731e-03 2.031 1 0
Reproduction R-HSA-1474165 9.536735e-03 2.021 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 9.556477e-03 2.020 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 9.556477e-03 2.020 0 0
Maturation of protein E R-HSA-9694493 9.556477e-03 2.020 0 0
Maturation of protein E R-HSA-9683683 9.556477e-03 2.020 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.579489e-03 2.019 1 0
Attenuation phase R-HSA-3371568 9.944740e-03 2.002 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.944740e-03 2.002 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.944740e-03 2.002 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.026929e-02 1.988 0 0
RAF activation R-HSA-5673000 1.045823e-02 1.981 1 1
Dual Incision in GG-NER R-HSA-5696400 1.045823e-02 1.981 0 0
Nuclear import of Rev protein R-HSA-180746 1.045823e-02 1.981 0 0
HATs acetylate histones R-HSA-3214847 1.060713e-02 1.974 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.066259e-02 1.972 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.109653e-02 1.955 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.109653e-02 1.955 0 0
Interleukin-12 family signaling R-HSA-447115 1.115946e-02 1.952 0 0
Co-inhibition by PD-1 R-HSA-389948 1.168445e-02 1.932 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.411969e-02 1.850 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.411969e-02 1.850 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.411969e-02 1.850 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.270956e-02 1.896 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.307480e-02 1.884 0 0
MAP2K and MAPK activation R-HSA-5674135 1.316892e-02 1.880 0 0
rRNA processing R-HSA-72312 1.230158e-02 1.910 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.411969e-02 1.850 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.271618e-02 1.896 0 0
FLT3 signaling in disease R-HSA-9682385 1.411952e-02 1.850 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.411969e-02 1.850 0 0
Influenza Infection R-HSA-168255 1.393667e-02 1.856 0 0
HCMV Early Events R-HSA-9609690 1.485897e-02 1.828 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.490665e-02 1.827 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.490665e-02 1.827 0 0
Budding and maturation of HIV virion R-HSA-162588 1.490665e-02 1.827 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.505121e-02 1.822 0 0
Depyrimidination R-HSA-73928 1.505121e-02 1.822 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.510757e-02 1.821 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.518316e-02 1.819 0 0
Nephrin family interactions R-HSA-373753 1.525020e-02 1.817 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.577997e-02 1.802 0 0
Signaling by EGFR R-HSA-177929 1.586975e-02 1.799 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.612936e-02 1.792 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.627925e-02 1.788 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.627925e-02 1.788 0 0
Host Interactions of HIV factors R-HSA-162909 1.654070e-02 1.781 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.767361e-02 1.753 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.780423e-02 1.749 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.804089e-02 1.744 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.804089e-02 1.744 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.804089e-02 1.744 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.804089e-02 1.744 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.804089e-02 1.744 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.804089e-02 1.744 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.848274e-02 1.733 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.866317e-02 1.729 0 0
Signaling by VEGF R-HSA-194138 1.913707e-02 1.718 0 0
EPH-Ephrin signaling R-HSA-2682334 1.918723e-02 1.717 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.925233e-02 1.716 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.925233e-02 1.716 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.991512e-02 1.701 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.012041e-02 1.696 1 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.012041e-02 1.696 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.504960e-02 1.601 0 0
Aggrephagy R-HSA-9646399 2.419796e-02 1.616 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.409053e-02 1.618 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.404565e-02 1.619 0 0
HIV Infection R-HSA-162906 2.265551e-02 1.645 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.059248e-02 1.686 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.123873e-02 1.673 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.206509e-02 1.656 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.206509e-02 1.656 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.504960e-02 1.601 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.504960e-02 1.601 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.317028e-02 1.635 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.130008e-02 1.672 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.504960e-02 1.601 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.551143e-02 1.593 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.615872e-02 1.582 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.631730e-02 1.580 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.662192e-02 1.575 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.700892e-02 1.568 0 0
Formation of annular gap junctions R-HSA-196025 2.700892e-02 1.568 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.700892e-02 1.568 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.700892e-02 1.568 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.700892e-02 1.568 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.736938e-02 1.563 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.919735e-02 1.535 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.023378e-02 1.520 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.024124e-02 1.519 0 0
DNA Repair R-HSA-73894 3.036009e-02 1.518 0 0
Signaling by NOTCH3 R-HSA-9012852 3.043679e-02 1.517 0 0
Syndecan interactions R-HSA-3000170 3.074172e-02 1.512 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.082634e-02 1.511 0 0
Ribosome-associated quality control R-HSA-9948299 3.086363e-02 1.511 0 0
Telomere Maintenance R-HSA-157579 3.106702e-02 1.508 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.129233e-02 1.505 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.129233e-02 1.505 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.171302e-02 1.499 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.188561e-02 1.496 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.188561e-02 1.496 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.263889e-02 1.486 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.312940e-02 1.480 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.365509e-02 1.473 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.365509e-02 1.473 0 0
HSF1 activation R-HSA-3371511 3.427585e-02 1.465 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.427585e-02 1.465 0 0
Degradation of CDH1 R-HSA-9766229 3.431180e-02 1.465 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.448358e-02 1.462 0 0
Lipophagy R-HSA-9613354 3.539491e-02 1.451 0 0
Gap junction degradation R-HSA-190873 3.539491e-02 1.451 0 0
Calcineurin activates NFAT R-HSA-2025928 3.539491e-02 1.451 0 0
Unwinding of DNA R-HSA-176974 3.539491e-02 1.451 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.539491e-02 1.451 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.548007e-02 1.450 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.548007e-02 1.450 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.583481e-02 1.446 0 0
Autophagy R-HSA-9612973 3.663041e-02 1.436 0 0
EGFR downregulation R-HSA-182971 3.788081e-02 1.422 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.790647e-02 1.421 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.790647e-02 1.421 0 0
Rap1 signalling R-HSA-392517 3.790647e-02 1.421 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.799177e-02 1.420 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.799177e-02 1.420 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.923272e-02 1.308 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.460691e-02 1.351 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.460691e-02 1.351 0 0
Orc1 removal from chromatin R-HSA-68949 4.638316e-02 1.334 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.638316e-02 1.334 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.097899e-02 1.293 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.073279e-02 1.295 0 0
HDMs demethylate histones R-HSA-3214842 4.145585e-02 1.382 0 0
Translesion synthesis by REV1 R-HSA-110312 4.648293e-02 1.333 0 0
Neurexins and neuroligins R-HSA-6794361 4.638316e-02 1.334 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.680190e-02 1.330 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.097899e-02 1.293 0 0
Protein methylation R-HSA-8876725 4.648293e-02 1.333 0 0
Eukaryotic Translation Termination R-HSA-72764 4.732873e-02 1.325 0 0
Cilium Assembly R-HSA-5617833 4.100162e-02 1.387 0 0
Vesicle-mediated transport R-HSA-5653656 4.648034e-02 1.333 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.870430e-02 1.312 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.842938e-02 1.415 0 0
Kinesins R-HSA-983189 4.895463e-02 1.310 0 0
Selective autophagy R-HSA-9663891 4.338077e-02 1.363 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.761966e-02 1.322 0 0
MAPK family signaling cascades R-HSA-5683057 4.951973e-02 1.305 1 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 4.446568e-02 1.352 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.772336e-02 1.321 0 0
Negative regulation of MET activity R-HSA-6807004 4.460691e-02 1.351 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.867531e-02 1.413 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.648293e-02 1.333 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.648293e-02 1.333 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.169714e-02 1.380 0 0
Base Excision Repair R-HSA-73884 5.023984e-02 1.299 0 0
p75NTR signals via NF-kB R-HSA-193639 4.648293e-02 1.333 0 0
Pexophagy R-HSA-9664873 4.512448e-02 1.346 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.200173e-02 1.284 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.200173e-02 1.284 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.412507e-02 1.267 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.433786e-02 1.265 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.433786e-02 1.265 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.433786e-02 1.265 0 0
Translesion synthesis by POLI R-HSA-5656121 5.546500e-02 1.256 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.546500e-02 1.256 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.587188e-02 1.253 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.619787e-02 1.250 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.813832e-02 1.236 0 0
tRNA processing in the nucleus R-HSA-6784531 5.815125e-02 1.235 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.977342e-02 1.223 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.005416e-02 1.221 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.010033e-02 1.221 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.135764e-02 1.212 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.161880e-02 1.210 1 1
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.315494e-02 1.200 0 0
Signaling by PTK6 R-HSA-8848021 6.315494e-02 1.200 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.325183e-02 1.199 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 6.325183e-02 1.199 0 0
HCMV Infection R-HSA-9609646 6.469466e-02 1.189 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.519191e-02 1.186 0 0
Disorders of Developmental Biology R-HSA-9675151 6.537774e-02 1.185 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.537774e-02 1.185 0 0
Translesion synthesis by POLK R-HSA-5655862 6.537774e-02 1.185 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.537774e-02 1.185 0 0
Sensory processing of sound R-HSA-9659379 6.549496e-02 1.184 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.575402e-02 1.182 0 0
Hedgehog 'off' state R-HSA-5610787 6.606424e-02 1.180 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.638347e-02 1.178 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.638347e-02 1.178 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.638347e-02 1.178 0 0
Ion transport by P-type ATPases R-HSA-936837 6.843430e-02 1.165 1 1
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.859460e-02 1.164 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.859460e-02 1.164 0 0
Integration of provirus R-HSA-162592 6.859460e-02 1.164 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 6.859460e-02 1.164 0 0
NF-kB is activated and signals survival R-HSA-209560 6.859460e-02 1.164 0 0
mTORC1-mediated signalling R-HSA-166208 6.890673e-02 1.162 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.946750e-02 1.158 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.946750e-02 1.158 0 0
DARPP-32 events R-HSA-180024 6.946750e-02 1.158 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.964540e-02 1.157 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.993504e-02 1.155 0 0
Selenocysteine synthesis R-HSA-2408557 7.033971e-02 1.153 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.034513e-02 1.153 0 0
Interferon Signaling R-HSA-913531 7.108381e-02 1.148 1 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.130203e-02 1.147 1 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.236961e-02 1.140 0 0
MTOR signalling R-HSA-165159 7.311704e-02 1.136 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.495885e-02 1.125 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 9.660838e-02 1.015 0 0
PDGFR mutants bind TKIs R-HSA-9674428 9.660838e-02 1.015 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 9.660838e-02 1.015 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 9.660838e-02 1.015 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 9.660838e-02 1.015 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 9.660838e-02 1.015 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 9.660838e-02 1.015 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.660838e-02 1.015 0 0
MET interacts with TNS proteins R-HSA-8875513 9.261025e-02 1.033 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 9.261025e-02 1.033 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 9.261025e-02 1.033 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 8.320321e-02 1.080 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 8.320321e-02 1.080 0 0
Type I hemidesmosome assembly R-HSA-446107 1.030828e-01 0.987 0 0
Pervasive developmental disorders R-HSA-9005895 8.227590e-02 1.085 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.227590e-02 1.085 0 0
Disorders of Nervous System Development R-HSA-9697154 8.227590e-02 1.085 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.227590e-02 1.085 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.227590e-02 1.085 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.227590e-02 1.085 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.227590e-02 1.085 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.227590e-02 1.085 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.621384e-02 1.118 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.863252e-02 1.052 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.041181e-01 0.982 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.777692e-02 1.010 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.777692e-02 1.010 0 0
Viral mRNA Translation R-HSA-192823 7.943744e-02 1.100 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.013059e-01 0.994 0 0
Nucleotide Excision Repair R-HSA-5696398 9.447384e-02 1.025 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.635193e-02 1.064 0 0
Translesion Synthesis by POLH R-HSA-110320 1.005834e-01 0.997 0 0
DNA strand elongation R-HSA-69190 9.642056e-02 1.016 0 0
Metalloprotease DUBs R-HSA-5689901 1.111083e-01 0.954 0 0
Nuclear RNA decay R-HSA-9930044 1.065245e-01 0.973 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.132828e-01 0.946 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.132828e-01 0.946 0 0
Trafficking of AMPA receptors R-HSA-399719 8.687162e-02 1.061 1 1
Clathrin-mediated endocytosis R-HSA-8856828 1.041816e-01 0.982 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.118874e-01 0.951 1 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.927487e-02 1.049 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.927487e-02 1.049 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.387388e-02 1.076 0 0
S Phase R-HSA-69242 8.844011e-02 1.053 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.575947e-02 1.019 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.575947e-02 1.019 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.575947e-02 1.019 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.112078e-01 0.954 0 0
Signaling by NOTCH1 R-HSA-1980143 9.243426e-02 1.034 0 0
CHL1 interactions R-HSA-447041 8.320321e-02 1.080 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.111083e-01 0.954 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.593407e-02 1.120 1 1
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.065245e-01 0.973 0 0
Cellular response to starvation R-HSA-9711097 9.478872e-02 1.023 0 0
PIP3 activates AKT signaling R-HSA-1257604 9.353560e-02 1.029 0 0
Platelet sensitization by LDL R-HSA-432142 8.795716e-02 1.056 0 0
Gene expression (Transcription) R-HSA-74160 8.555655e-02 1.068 1 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.575947e-02 1.019 0 0
G1/S Transition R-HSA-69206 8.507925e-02 1.070 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.170901e-02 1.038 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.227590e-02 1.085 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 9.642056e-02 1.016 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.106438e-01 0.956 0 0
Signaling by TGFB family members R-HSA-9006936 1.036116e-01 0.985 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.128770e-01 0.947 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.687162e-02 1.061 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.227590e-02 1.085 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.227590e-02 1.085 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.065245e-01 0.973 1 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.028261e-02 1.044 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.056254e-01 0.976 0 0
Neurodegenerative Diseases R-HSA-8863678 8.863252e-02 1.052 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 8.863252e-02 1.052 0 0
Glycogen metabolism R-HSA-8982491 1.106438e-01 0.956 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.132828e-01 0.946 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.780505e-02 1.056 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.687162e-02 1.061 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 8.289674e-02 1.081 0 0
Signaling by ERBB4 R-HSA-1236394 8.052715e-02 1.094 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.041181e-01 0.982 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.564917e-02 1.019 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.138253e-01 0.944 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.138747e-01 0.944 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.140608e-01 0.943 0 0
Glycogen synthesis R-HSA-3322077 1.140608e-01 0.943 0 0
SARS-CoV Infections R-HSA-9679506 1.174227e-01 0.930 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.192113e-01 0.924 0 0
PKR-mediated signaling R-HSA-9833482 1.193381e-01 0.923 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.218872e-01 0.914 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.223725e-01 0.912 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.223725e-01 0.912 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.233349e-01 0.909 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.233349e-01 0.909 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.233349e-01 0.909 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.233349e-01 0.909 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.246285e-01 0.904 0 0
Regulation of gap junction activity R-HSA-191650 1.250404e-01 0.903 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.250404e-01 0.903 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.250404e-01 0.903 0 0
NADE modulates death signalling R-HSA-205025 1.250404e-01 0.903 0 0
RNA Polymerase II Transcription R-HSA-73857 1.271038e-01 0.896 1 0
NOD1/2 Signaling Pathway R-HSA-168638 1.283504e-01 0.892 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.283512e-01 0.892 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.283512e-01 0.892 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.283512e-01 0.892 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.291662e-01 0.889 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.291662e-01 0.889 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.291662e-01 0.889 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.304178e-01 0.885 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.304178e-01 0.885 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.304178e-01 0.885 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.304178e-01 0.885 0 0
HCMV Late Events R-HSA-9610379 1.316348e-01 0.881 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.325186e-01 0.878 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.328048e-01 0.877 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.359883e-01 0.866 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.361894e-01 0.866 0 0
HIV elongation arrest and recovery R-HSA-167287 1.361894e-01 0.866 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.361894e-01 0.866 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.361894e-01 0.866 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.361894e-01 0.866 0 0
Signaling by NOTCH4 R-HSA-9013694 1.367221e-01 0.864 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.400420e-01 0.854 0 0
Dual incision in TC-NER R-HSA-6782135 1.404869e-01 0.852 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.414915e-01 0.849 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.434105e-01 0.843 0 0
2-LTR circle formation R-HSA-164843 1.476280e-01 0.831 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.476280e-01 0.831 0 0
Regulation of CDH11 function R-HSA-9762292 1.476280e-01 0.831 0 0
Viral Infection Pathways R-HSA-9824446 1.484000e-01 0.829 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.485715e-01 0.828 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.485715e-01 0.828 0 0
Regulation of BACH1 activity R-HSA-9708530 1.485715e-01 0.828 0 0
Negative regulation of FLT3 R-HSA-9706369 1.485715e-01 0.828 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.496441e-01 0.825 0 0
Regulation of insulin secretion R-HSA-422356 1.506528e-01 0.822 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.517806e-01 0.819 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.526688e-01 0.816 0 0
UCH proteinases R-HSA-5689603 1.537019e-01 0.813 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.562399e-01 0.806 1 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.586289e-01 0.800 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.591898e-01 0.798 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.596756e-01 0.797 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.596756e-01 0.797 0 0
Muscarinic acetylcholine receptors R-HSA-390648 1.596756e-01 0.797 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.596756e-01 0.797 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.596756e-01 0.797 0 0
Signaling by ERBB2 R-HSA-1227986 1.599135e-01 0.796 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.599135e-01 0.796 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.599135e-01 0.796 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.599135e-01 0.796 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.599135e-01 0.796 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.599135e-01 0.796 0 0
Synthesis of DNA R-HSA-69239 1.613669e-01 0.792 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.624275e-01 0.789 0 0
Activation of the pre-replicative complex R-HSA-68962 1.636677e-01 0.786 0 0
Activation of BH3-only proteins R-HSA-114452 1.636677e-01 0.786 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.639537e-01 0.785 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.648878e-01 0.783 0 0
Degradation of DVL R-HSA-4641258 1.648878e-01 0.783 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.838887e-01 0.735 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.838887e-01 0.735 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.838887e-01 0.735 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.838887e-01 0.735 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.838887e-01 0.735 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.838887e-01 0.735 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.838887e-01 0.735 0 0
Hereditary fructose intolerance R-HSA-5657560 1.838887e-01 0.735 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.627412e-01 0.580 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.627412e-01 0.580 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.627412e-01 0.580 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.627412e-01 0.580 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 2.627412e-01 0.580 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.627412e-01 0.580 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.627412e-01 0.580 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.627412e-01 0.580 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.627412e-01 0.580 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.957878e-01 0.708 0 0
Cam-PDE 1 activation R-HSA-111957 1.957878e-01 0.708 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.957878e-01 0.708 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.957878e-01 0.708 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.957878e-01 0.708 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.957878e-01 0.708 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.339792e-01 0.476 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.339792e-01 0.476 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.339792e-01 0.476 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.339792e-01 0.476 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.339792e-01 0.476 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.339792e-01 0.476 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.339792e-01 0.476 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.339792e-01 0.476 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.339792e-01 0.476 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.339792e-01 0.476 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.339792e-01 0.476 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.339792e-01 0.476 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.339792e-01 0.476 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.339792e-01 0.476 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.339792e-01 0.476 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.327687e-01 0.633 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.327687e-01 0.633 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.327687e-01 0.633 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.327687e-01 0.633 0 0
PECAM1 interactions R-HSA-210990 1.718661e-01 0.765 0 0
Signaling by APC mutants R-HSA-4839744 1.718661e-01 0.765 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.718661e-01 0.765 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.718661e-01 0.765 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.718661e-01 0.765 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.971299e-01 0.705 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.701139e-01 0.568 0 0
Recycling of eIF2:GDP R-HSA-72731 2.701139e-01 0.568 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 2.701139e-01 0.568 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.701139e-01 0.568 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.874911e-01 0.727 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.074082e-01 0.512 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.074082e-01 0.512 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.074082e-01 0.512 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.074082e-01 0.512 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.499172e-01 0.602 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.499172e-01 0.602 0 0
Formation of axial mesoderm R-HSA-9796292 2.499172e-01 0.602 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.080593e-01 0.682 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.926935e-01 0.715 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.292320e-01 0.640 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.292320e-01 0.640 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.770576e-01 0.557 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.782264e-01 0.749 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.509089e-01 0.600 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.509089e-01 0.600 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.509089e-01 0.600 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.509089e-01 0.600 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.932838e-01 0.714 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.044608e-01 0.516 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.915316e-01 0.718 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.247402e-01 0.648 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.319679e-01 0.479 0 0
HIV Transcription Elongation R-HSA-167169 2.054640e-01 0.687 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.054640e-01 0.687 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.054640e-01 0.687 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.884992e-01 0.725 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.011729e-01 0.696 0 0
FGFR2 alternative splicing R-HSA-6803529 3.179892e-01 0.498 0 0
Notch-HLH transcription pathway R-HSA-350054 3.179892e-01 0.498 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.179892e-01 0.498 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.493629e-01 0.603 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.045077e-01 0.516 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.957756e-01 0.529 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.284052e-01 0.641 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.080593e-01 0.682 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.197663e-01 0.658 0 0
Integrin signaling R-HSA-354192 2.088017e-01 0.680 0 0
DNA Damage Bypass R-HSA-73893 2.274934e-01 0.643 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.053653e-01 0.687 0 0
Polo-like kinase mediated events R-HSA-156711 2.080593e-01 0.682 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.800775e-01 0.553 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.247402e-01 0.648 0 0
DCC mediated attractive signaling R-HSA-418885 3.044608e-01 0.516 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.088017e-01 0.680 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.761988e-01 0.754 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.177998e-01 0.662 0 0
GAB1 signalosome R-HSA-180292 2.080593e-01 0.682 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.690695e-01 0.570 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.957756e-01 0.529 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.821192e-01 0.740 0 0
PKA activation R-HSA-163615 2.080593e-01 0.682 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.044608e-01 0.516 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.493629e-01 0.603 0 0
Ca2+ pathway R-HSA-4086398 2.070370e-01 0.684 1 1
Myogenesis R-HSA-525793 2.284052e-01 0.641 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.729908e-01 0.564 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.469381e-01 0.607 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.884992e-01 0.725 0 0
Gap junction trafficking and regulation R-HSA-157858 2.274934e-01 0.643 0 0
PTEN Regulation R-HSA-6807070 1.763027e-01 0.754 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.965088e-01 0.707 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.957878e-01 0.708 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.080593e-01 0.682 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.509089e-01 0.600 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.197663e-01 0.658 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.197663e-01 0.658 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.577138e-01 0.589 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.577138e-01 0.589 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.493629e-01 0.603 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.761988e-01 0.754 0 0
Gap junction trafficking R-HSA-190828 2.800775e-01 0.553 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.847469e-01 0.733 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.773941e-01 0.751 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.171389e-01 0.663 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.847469e-01 0.733 0 0
Formation of definitive endoderm R-HSA-9823730 2.509089e-01 0.600 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.957878e-01 0.708 0 0
Stabilization of p53 R-HSA-69541 1.915316e-01 0.718 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.327687e-01 0.633 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.915316e-01 0.718 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.884992e-01 0.725 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.088017e-01 0.680 0 0
Integration of energy metabolism R-HSA-163685 2.981610e-01 0.526 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.850503e-01 0.545 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.838887e-01 0.735 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.627412e-01 0.580 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.339792e-01 0.476 0 0
Interleukin-33 signaling R-HSA-9014843 3.339792e-01 0.476 0 0
C6 deamination of adenosine R-HSA-75102 3.339792e-01 0.476 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.339792e-01 0.476 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.971299e-01 0.705 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.971299e-01 0.705 0 0
Signaling by AXIN mutants R-HSA-4839735 1.971299e-01 0.705 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.874911e-01 0.727 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.080593e-01 0.682 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.054640e-01 0.687 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.658402e-01 0.575 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.410582e-01 0.618 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.700971e-01 0.769 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.805806e-01 0.743 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.274934e-01 0.643 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.274934e-01 0.643 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.746645e-01 0.561 0 0
TBC/RABGAPs R-HSA-8854214 2.645960e-01 0.577 0 0
Degradation of AXIN R-HSA-4641257 2.918678e-01 0.535 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.800775e-01 0.553 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.268630e-01 0.486 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.979066e-01 0.526 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.853296e-01 0.545 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.988803e-01 0.525 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.449425e-01 0.611 0 0
Rab regulation of trafficking R-HSA-9007101 2.637197e-01 0.579 0 0
Signaling by TGFBR3 R-HSA-9839373 3.116588e-01 0.506 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.882371e-01 0.725 0 0
Macroautophagy R-HSA-1632852 1.903877e-01 0.720 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.088017e-01 0.680 0 0
TNF signaling R-HSA-75893 2.083266e-01 0.681 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.241530e-01 0.489 0 0
Signaling by Hedgehog R-HSA-5358351 2.361483e-01 0.627 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.676284e-01 0.776 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.249880e-01 0.648 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.249880e-01 0.648 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.249880e-01 0.648 0 0
Atorvastatin ADME R-HSA-9754706 3.319679e-01 0.479 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.545091e-01 0.594 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.096903e-01 0.678 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.701139e-01 0.568 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.074082e-01 0.512 0 0
Basigin interactions R-HSA-210991 2.729908e-01 0.564 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.247402e-01 0.648 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.319679e-01 0.479 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.410582e-01 0.618 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.410582e-01 0.618 0 0
Regulation of Apoptosis R-HSA-169911 2.577138e-01 0.589 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.433940e-01 0.614 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.410582e-01 0.618 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.967001e-01 0.528 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 2.701139e-01 0.568 0 0
Hedgehog 'on' state R-HSA-5632684 1.862260e-01 0.730 0 0
MAP kinase activation R-HSA-450294 2.719514e-01 0.566 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.627412e-01 0.580 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.957878e-01 0.708 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.327687e-01 0.633 0 0
RAS processing R-HSA-9648002 3.268630e-01 0.486 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.045077e-01 0.516 0 0
Mitophagy R-HSA-5205647 2.410582e-01 0.618 0 0
Cardiac conduction R-HSA-5576891 2.448272e-01 0.611 1 0
Signaling by MET R-HSA-6806834 2.866309e-01 0.543 0 0
Signaling by NOTCH2 R-HSA-1980145 2.410582e-01 0.618 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.088017e-01 0.680 0 0
Interleukin-18 signaling R-HSA-9012546 3.074082e-01 0.512 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.088017e-01 0.680 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.666968e-01 0.574 1 0
Insulin processing R-HSA-264876 2.469381e-01 0.607 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.981807e-01 0.703 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.915316e-01 0.718 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 2.469381e-01 0.607 0 0
Signaling by Interleukins R-HSA-449147 1.919980e-01 0.717 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.676284e-01 0.776 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.044608e-01 0.516 0 0
Ion channel transport R-HSA-983712 2.253931e-01 0.647 1 0
FLT3 Signaling R-HSA-9607240 2.197663e-01 0.658 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.493629e-01 0.603 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.729908e-01 0.564 0 0
Inositol phosphate metabolism R-HSA-1483249 2.840043e-01 0.547 0 0
Regulation of signaling by CBL R-HSA-912631 2.292320e-01 0.640 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.729908e-01 0.564 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.850503e-01 0.545 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.083266e-01 0.681 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.729908e-01 0.564 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.953818e-01 0.530 0 0
Glycogen storage diseases R-HSA-3229121 1.874911e-01 0.727 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.385090e-01 0.470 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.407244e-01 0.468 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.423502e-01 0.466 0 0
GPER1 signaling R-HSA-9634597 3.438541e-01 0.464 0 0
Gluconeogenesis R-HSA-70263 3.438541e-01 0.464 0 0
G0 and Early G1 R-HSA-1538133 3.439283e-01 0.464 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.443129e-01 0.463 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.443129e-01 0.463 0 0
WNT mediated activation of DVL R-HSA-201688 3.443129e-01 0.463 0 0
ALK mutants bind TKIs R-HSA-9700645 3.443129e-01 0.463 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.443129e-01 0.463 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.443129e-01 0.463 0 0
ARMS-mediated activation R-HSA-170984 3.443129e-01 0.463 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.443129e-01 0.463 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.443129e-01 0.463 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.445716e-01 0.463 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.487785e-01 0.457 0 0
Interleukin-1 signaling R-HSA-9020702 3.531279e-01 0.452 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.594339e-01 0.444 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.594339e-01 0.444 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.594339e-01 0.444 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.594339e-01 0.444 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.594339e-01 0.444 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.594339e-01 0.444 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 3.601042e-01 0.444 0 0
TCR signaling R-HSA-202403 3.604781e-01 0.443 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.623666e-01 0.441 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.623666e-01 0.441 0 0
Deadenylation of mRNA R-HSA-429947 3.635037e-01 0.439 0 0
G-protein beta:gamma signalling R-HSA-397795 3.637780e-01 0.439 0 0
Cardiogenesis R-HSA-9733709 3.637780e-01 0.439 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.671085e-01 0.435 0 0
Interleukin-1 family signaling R-HSA-446652 3.695346e-01 0.432 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.724840e-01 0.429 0 0
Platelet degranulation R-HSA-114608 3.731362e-01 0.428 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.778037e-01 0.423 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.778037e-01 0.423 0 0
PCP/CE pathway R-HSA-4086400 3.779256e-01 0.423 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.802087e-01 0.420 0 0
Translation of Structural Proteins R-HSA-9683701 3.802087e-01 0.420 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.805554e-01 0.420 0 0
Binding and entry of HIV virion R-HSA-173107 3.805554e-01 0.420 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.805554e-01 0.420 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.805554e-01 0.420 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.805554e-01 0.420 0 0
Tandem pore domain potassium channels R-HSA-1296346 3.805554e-01 0.420 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.805554e-01 0.420 0 0
Signaling by Leptin R-HSA-2586552 3.805554e-01 0.420 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.826874e-01 0.417 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.836484e-01 0.416 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.862484e-01 0.413 0 0
TGFBR3 expression R-HSA-9839394 3.862484e-01 0.413 0 0
Interleukin-7 signaling R-HSA-1266695 3.862484e-01 0.413 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.867283e-01 0.413 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.867283e-01 0.413 0 0
Specification of primordial germ cells R-HSA-9827857 3.867283e-01 0.413 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.927577e-01 0.406 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.957001e-01 0.403 0 0
Interleukin-17 signaling R-HSA-448424 3.968873e-01 0.401 0 0
Axonal growth stimulation R-HSA-209563 3.983376e-01 0.400 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.983376e-01 0.400 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.983376e-01 0.400 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.983376e-01 0.400 0 0
MET activates PTPN11 R-HSA-8865999 3.983376e-01 0.400 0 0
Defective ABCC2 causes DJS R-HSA-5679001 3.983376e-01 0.400 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 3.983376e-01 0.400 0 0
Invadopodia formation R-HSA-8941237 3.983376e-01 0.400 0 0
Histamine receptors R-HSA-390650 3.983376e-01 0.400 0 0
The NLRP1 inflammasome R-HSA-844455 3.983376e-01 0.400 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.034885e-01 0.394 0 0
Signaling by FGFR2 R-HSA-5654738 4.047238e-01 0.393 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.052579e-01 0.392 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.088853e-01 0.388 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.088853e-01 0.388 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.088853e-01 0.388 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.100977e-01 0.387 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.100977e-01 0.387 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.111020e-01 0.386 0 0
ER-Phagosome pathway R-HSA-1236974 4.114893e-01 0.386 0 0
Adaptive Immune System R-HSA-1280218 4.120962e-01 0.385 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.137348e-01 0.383 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.137348e-01 0.383 0 0
PKA activation in glucagon signalling R-HSA-164378 4.137348e-01 0.383 0 0
Ephrin signaling R-HSA-3928664 4.137348e-01 0.383 0 0
Mismatch Repair R-HSA-5358508 4.137348e-01 0.383 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.137348e-01 0.383 0 0
Signaling by FGFR4 R-HSA-5654743 4.158842e-01 0.381 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.158842e-01 0.381 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.159192e-01 0.381 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.159192e-01 0.381 0 0
Suppression of apoptosis R-HSA-9635465 4.159192e-01 0.381 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.174227e-01 0.379 0 0
MHC class II antigen presentation R-HSA-2132295 4.209041e-01 0.376 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.229061e-01 0.374 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.232499e-01 0.373 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.254230e-01 0.371 0 0
Post-translational protein phosphorylation R-HSA-8957275 4.295914e-01 0.367 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.313468e-01 0.365 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.313468e-01 0.365 0 0
Cristae formation R-HSA-8949613 4.313468e-01 0.365 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.313468e-01 0.365 0 0
Developmental Cell Lineages R-HSA-9734767 4.323259e-01 0.364 0 0
G1 Phase R-HSA-69236 4.336460e-01 0.363 0 0
Cyclin D associated events in G1 R-HSA-69231 4.336460e-01 0.363 0 0
RMTs methylate histone arginines R-HSA-3214858 4.336460e-01 0.363 0 0
Netrin-1 signaling R-HSA-373752 4.336460e-01 0.363 0 0
Generic Transcription Pathway R-HSA-212436 4.397399e-01 0.357 1 0
Germ layer formation at gastrulation R-HSA-9754189 4.403508e-01 0.356 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.403508e-01 0.356 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.403508e-01 0.356 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.403508e-01 0.356 0 0
The NLRP3 inflammasome R-HSA-844456 4.403508e-01 0.356 0 0
Other interleukin signaling R-HSA-449836 4.403508e-01 0.356 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 4.403508e-01 0.356 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.403508e-01 0.356 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.428872e-01 0.354 0 0
RNA Polymerase III Transcription R-HSA-74158 4.428872e-01 0.354 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.428872e-01 0.354 0 0
G1/S-Specific Transcription R-HSA-69205 4.428872e-01 0.354 0 0
Neuronal System R-HSA-112316 4.442059e-01 0.352 1 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.502359e-01 0.347 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.502359e-01 0.347 0 0
Sodium/Calcium exchangers R-HSA-425561 4.502359e-01 0.347 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.502359e-01 0.347 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.513123e-01 0.346 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.513123e-01 0.346 0 0
Signaling by FGFR3 R-HSA-5654741 4.513123e-01 0.346 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.513123e-01 0.346 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.535708e-01 0.343 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.535708e-01 0.343 0 0
Inflammasomes R-HSA-622312 4.535708e-01 0.343 0 0
ABC-family proteins mediated transport R-HSA-382556 4.538950e-01 0.343 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.564804e-01 0.341 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.564804e-01 0.341 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.564804e-01 0.341 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.564804e-01 0.341 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.564804e-01 0.341 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.564804e-01 0.341 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.564804e-01 0.341 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.564804e-01 0.341 0 0
Sensory perception of sour taste R-HSA-9729555 4.564804e-01 0.341 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.564804e-01 0.341 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.664868e-01 0.331 0 0
Signal transduction by L1 R-HSA-445144 4.664868e-01 0.331 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.688516e-01 0.329 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.755008e-01 0.323 0 0
Platelet calcium homeostasis R-HSA-418360 4.755008e-01 0.323 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.816222e-01 0.317 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.833777e-01 0.316 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.833777e-01 0.316 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.833777e-01 0.316 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 4.833777e-01 0.316 0 0
Polymerase switching R-HSA-69091 4.833777e-01 0.316 0 0
Leading Strand Synthesis R-HSA-69109 4.833777e-01 0.316 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.833777e-01 0.316 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.833777e-01 0.316 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.833777e-01 0.316 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.833777e-01 0.316 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.848768e-01 0.314 0 0
Lagging Strand Synthesis R-HSA-69186 4.920659e-01 0.308 0 0
G-protein activation R-HSA-202040 4.920659e-01 0.308 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 4.920659e-01 0.308 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.970863e-01 0.304 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.970863e-01 0.304 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.970863e-01 0.304 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.970863e-01 0.304 0 0
Interleukin-37 signaling R-HSA-9008059 4.970863e-01 0.304 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.980762e-01 0.303 0 0
Intraflagellar transport R-HSA-5620924 5.034331e-01 0.298 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.034331e-01 0.298 0 0
Co-stimulation by CD28 R-HSA-389356 5.034331e-01 0.298 0 0
Translation R-HSA-72766 5.036178e-01 0.298 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.057515e-01 0.296 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.077530e-01 0.294 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.090075e-01 0.293 0 0
IRS activation R-HSA-74713 5.090075e-01 0.293 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.090075e-01 0.293 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.090075e-01 0.293 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.090075e-01 0.293 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.090075e-01 0.293 0 0
Inositol transporters R-HSA-429593 5.090075e-01 0.293 0 0
Interleukin-36 pathway R-HSA-9014826 5.090075e-01 0.293 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.090075e-01 0.293 0 0
NrCAM interactions R-HSA-447038 5.090075e-01 0.293 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.090075e-01 0.293 0 0
Co-inhibition by BTLA R-HSA-9927353 5.090075e-01 0.293 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.090075e-01 0.293 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.090075e-01 0.293 0 0
Transmission across Chemical Synapses R-HSA-112315 5.128122e-01 0.290 1 0
RSV-host interactions R-HSA-9833110 5.139522e-01 0.289 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.152512e-01 0.288 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.152512e-01 0.288 0 0
Frs2-mediated activation R-HSA-170968 5.152512e-01 0.288 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.152512e-01 0.288 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.152512e-01 0.288 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.153484e-01 0.288 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.170227e-01 0.286 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.182819e-01 0.285 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.182819e-01 0.285 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.193901e-01 0.285 0 0
Diseases of Immune System R-HSA-5260271 5.193901e-01 0.285 0 0
Peroxisomal protein import R-HSA-9033241 5.214004e-01 0.283 0 0
Platelet homeostasis R-HSA-418346 5.374831e-01 0.270 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.378300e-01 0.269 0 0
Signaling by WNT in cancer R-HSA-4791275 5.390477e-01 0.268 0 0
Potential therapeutics for SARS R-HSA-9679191 5.393451e-01 0.268 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.413030e-01 0.267 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.413030e-01 0.267 0 0
Cellular hexose transport R-HSA-189200 5.413030e-01 0.267 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.413030e-01 0.267 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 5.413030e-01 0.267 0 0
Removal of the Flap Intermediate R-HSA-69166 5.457921e-01 0.263 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.457921e-01 0.263 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.457921e-01 0.263 0 0
Signal regulatory protein family interactions R-HSA-391160 5.457921e-01 0.263 0 0
Zinc transporters R-HSA-435354 5.457921e-01 0.263 0 0
HDL assembly R-HSA-8963896 5.457921e-01 0.263 0 0
Downstream TCR signaling R-HSA-202424 5.497114e-01 0.260 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.521189e-01 0.258 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 5.536757e-01 0.257 0 0
Plus-strand DNA synthesis R-HSA-164525 5.564611e-01 0.255 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.564611e-01 0.255 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.564611e-01 0.255 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.564611e-01 0.255 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.564611e-01 0.255 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.564611e-01 0.255 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.564611e-01 0.255 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.564611e-01 0.255 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.564611e-01 0.255 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.564611e-01 0.255 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.564611e-01 0.255 0 0
Intestinal hexose absorption R-HSA-8981373 5.564611e-01 0.255 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.564611e-01 0.255 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.564611e-01 0.255 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.564611e-01 0.255 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.564611e-01 0.255 0 0
Toll-like Receptor Cascades R-HSA-168898 5.585796e-01 0.253 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.593489e-01 0.252 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.593489e-01 0.252 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.593489e-01 0.252 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.593489e-01 0.252 0 0
Stimuli-sensing channels R-HSA-2672351 5.606234e-01 0.251 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.648625e-01 0.248 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 5.749602e-01 0.240 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.749602e-01 0.240 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.749602e-01 0.240 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.749602e-01 0.240 0 0
Selenoamino acid metabolism R-HSA-2408522 5.773135e-01 0.239 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.791557e-01 0.237 0 0
Protein folding R-HSA-391251 5.870796e-01 0.231 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 5.870796e-01 0.231 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.876662e-01 0.231 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.876662e-01 0.231 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.876662e-01 0.231 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.876662e-01 0.231 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.876662e-01 0.231 0 0
Plasma lipoprotein assembly R-HSA-8963898 5.876662e-01 0.231 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.984427e-01 0.223 0 0
Signal amplification R-HSA-392518 5.984427e-01 0.223 0 0
Gap junction assembly R-HSA-190861 5.984427e-01 0.223 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.984427e-01 0.223 0 0
Developmental Biology R-HSA-1266738 5.990266e-01 0.223 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.993309e-01 0.222 0 0
Signaling by LTK in cancer R-HSA-9842640 5.993309e-01 0.222 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.993309e-01 0.222 0 0
STAT5 Activation R-HSA-9645135 5.993309e-01 0.222 0 0
Uncoating of the HIV Virion R-HSA-162585 5.993309e-01 0.222 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 5.993309e-01 0.222 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 5.993309e-01 0.222 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 5.993309e-01 0.222 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.993309e-01 0.222 0 0
Neurofascin interactions R-HSA-447043 5.993309e-01 0.222 0 0
Lactose synthesis R-HSA-5653890 5.993309e-01 0.222 0 0
Abacavir transmembrane transport R-HSA-2161517 5.993309e-01 0.222 0 0
CREB phosphorylation R-HSA-199920 5.993309e-01 0.222 0 0
NADPH regeneration R-HSA-389542 5.993309e-01 0.222 0 0
Nef and signal transduction R-HSA-164944 5.993309e-01 0.222 0 0
VLDL assembly R-HSA-8866423 5.993309e-01 0.222 0 0
Phosphorylation of the APC/C R-HSA-176412 6.027357e-01 0.220 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.027357e-01 0.220 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.027357e-01 0.220 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.027357e-01 0.220 0 0
Prolonged ERK activation events R-HSA-169893 6.027357e-01 0.220 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.027357e-01 0.220 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.027357e-01 0.220 0 0
Activation of SMO R-HSA-5635838 6.027357e-01 0.220 0 0
Iron uptake and transport R-HSA-917937 6.060959e-01 0.217 0 0
Tight junction interactions R-HSA-420029 6.096875e-01 0.215 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.096875e-01 0.215 0 0
Neutrophil degranulation R-HSA-6798695 6.100849e-01 0.215 0 0
Cellular response to hypoxia R-HSA-1234174 6.107831e-01 0.214 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.148674e-01 0.211 0 0
G alpha (z) signalling events R-HSA-418597 6.167457e-01 0.210 0 0
PERK regulates gene expression R-HSA-381042 6.171893e-01 0.210 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.245846e-01 0.204 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.272091e-01 0.203 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.291152e-01 0.201 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.291152e-01 0.201 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.291152e-01 0.201 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.291152e-01 0.201 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.309074e-01 0.200 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.309074e-01 0.200 0 0
Signaling by FGFR1 R-HSA-5654736 6.317054e-01 0.199 0 0
Triglyceride catabolism R-HSA-163560 6.353786e-01 0.197 0 0
RET signaling R-HSA-8853659 6.353786e-01 0.197 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.376627e-01 0.195 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.380595e-01 0.195 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.380595e-01 0.195 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.380595e-01 0.195 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.380595e-01 0.195 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.380595e-01 0.195 0 0
SOS-mediated signalling R-HSA-112412 6.380595e-01 0.195 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.380595e-01 0.195 0 0
Disinhibition of SNARE formation R-HSA-114516 6.380595e-01 0.195 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.380595e-01 0.195 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.380595e-01 0.195 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.380595e-01 0.195 0 0
LDL remodeling R-HSA-8964041 6.380595e-01 0.195 0 0
VLDL clearance R-HSA-8964046 6.380595e-01 0.195 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.380595e-01 0.195 0 0
Netrin mediated repulsion signals R-HSA-418886 6.380595e-01 0.195 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.380595e-01 0.195 0 0
Maturation of replicase proteins R-HSA-9694301 6.380595e-01 0.195 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.393377e-01 0.194 0 0
ABC transporter disorders R-HSA-5619084 6.450235e-01 0.190 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.502265e-01 0.187 0 0
Transcription of the HIV genome R-HSA-167172 6.519468e-01 0.186 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.541090e-01 0.184 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.541090e-01 0.184 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.541090e-01 0.184 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.541090e-01 0.184 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.541090e-01 0.184 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.564079e-01 0.183 0 0
Interferon alpha/beta signaling R-HSA-909733 6.583377e-01 0.182 0 0
Signaling by FGFR R-HSA-190236 6.682162e-01 0.175 0 0
MET promotes cell motility R-HSA-8875878 6.700380e-01 0.174 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.700380e-01 0.174 0 0
Elastic fibre formation R-HSA-1566948 6.700380e-01 0.174 0 0
Insulin receptor recycling R-HSA-77387 6.709002e-01 0.173 0 0
NGF-stimulated transcription R-HSA-9031628 6.716535e-01 0.173 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.730466e-01 0.172 0 0
Minus-strand DNA synthesis R-HSA-164516 6.730466e-01 0.172 0 0
RSK activation R-HSA-444257 6.730466e-01 0.172 0 0
phospho-PLA2 pathway R-HSA-111995 6.730466e-01 0.172 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.730466e-01 0.172 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.730466e-01 0.172 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.730466e-01 0.172 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.730466e-01 0.172 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.730466e-01 0.172 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.730466e-01 0.172 0 0
Intestinal absorption R-HSA-8963676 6.730466e-01 0.172 0 0
Interleukin-23 signaling R-HSA-9020933 6.730466e-01 0.172 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.777385e-01 0.169 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.777385e-01 0.169 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.777385e-01 0.169 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.777385e-01 0.169 0 0
Nephron development R-HSA-9831926 6.777385e-01 0.169 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.777385e-01 0.169 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.777385e-01 0.169 0 0
Cellular response to chemical stress R-HSA-9711123 6.887980e-01 0.162 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.896665e-01 0.161 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.896665e-01 0.161 0 0
Glucagon-type ligand receptors R-HSA-420092 6.896665e-01 0.161 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.000340e-01 0.155 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.000340e-01 0.155 0 0
Specification of the neural plate border R-HSA-9834899 7.000340e-01 0.155 0 0
Generation of second messenger molecules R-HSA-202433 7.023589e-01 0.153 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.025964e-01 0.153 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.046535e-01 0.152 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.046535e-01 0.152 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.046535e-01 0.152 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.046535e-01 0.152 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.046535e-01 0.152 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.046535e-01 0.152 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.046535e-01 0.152 0 0
mRNA Editing R-HSA-75072 7.046535e-01 0.152 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.046535e-01 0.152 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.046535e-01 0.152 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.046535e-01 0.152 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.046535e-01 0.152 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.046535e-01 0.152 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.046535e-01 0.152 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.046535e-01 0.152 0 0
Interleukin-1 processing R-HSA-448706 7.046535e-01 0.152 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.046535e-01 0.152 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.046535e-01 0.152 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.046535e-01 0.152 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.064447e-01 0.151 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.076164e-01 0.150 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.123582e-01 0.147 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.141848e-01 0.146 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.176366e-01 0.144 0 0
Protein hydroxylation R-HSA-9629569 7.210324e-01 0.142 0 0
Downstream signal transduction R-HSA-186763 7.247582e-01 0.140 0 0
Cargo concentration in the ER R-HSA-5694530 7.247582e-01 0.140 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.323278e-01 0.135 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.323278e-01 0.135 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.332067e-01 0.135 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.332067e-01 0.135 0 0
PI3K/AKT activation R-HSA-198203 7.332067e-01 0.135 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.332067e-01 0.135 0 0
Metabolism of serotonin R-HSA-380612 7.332067e-01 0.135 0 0
Signal attenuation R-HSA-74749 7.332067e-01 0.135 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.332067e-01 0.135 0 0
CASP4 inflammasome assembly R-HSA-9948001 7.332067e-01 0.135 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.332067e-01 0.135 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.332067e-01 0.135 0 0
Interleukin-27 signaling R-HSA-9020956 7.332067e-01 0.135 0 0
Maturation of spike protein R-HSA-9683686 7.332067e-01 0.135 0 0
Circadian clock R-HSA-9909396 7.365314e-01 0.133 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.407762e-01 0.130 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.407762e-01 0.130 0 0
ERK/MAPK targets R-HSA-198753 7.407762e-01 0.130 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.407762e-01 0.130 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 7.407762e-01 0.130 0 0
Activation of GABAB receptors R-HSA-991365 7.464370e-01 0.127 0 0
GABA B receptor activation R-HSA-977444 7.464370e-01 0.127 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.475287e-01 0.126 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.497142e-01 0.125 0 0
Pyruvate metabolism R-HSA-70268 7.575190e-01 0.121 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.587061e-01 0.120 0 0
Translation of Structural Proteins R-HSA-9694635 7.587061e-01 0.120 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.590010e-01 0.120 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.590010e-01 0.120 0 0
vRNA Synthesis R-HSA-192814 7.590010e-01 0.120 0 0
Chylomicron assembly R-HSA-8963888 7.590010e-01 0.120 0 0
Bicarbonate transporters R-HSA-425381 7.590010e-01 0.120 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.590010e-01 0.120 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.590010e-01 0.120 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 7.590010e-01 0.120 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.590010e-01 0.120 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.593115e-01 0.120 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.593115e-01 0.120 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.655397e-01 0.116 0 0
Integrin cell surface interactions R-HSA-216083 7.689549e-01 0.114 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.714663e-01 0.113 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.714663e-01 0.113 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.714663e-01 0.113 0 0
Proteasome assembly R-HSA-9907900 7.729365e-01 0.112 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.766875e-01 0.110 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.766875e-01 0.110 0 0
LDL clearance R-HSA-8964038 7.766875e-01 0.110 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.766875e-01 0.110 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.771242e-01 0.110 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.823027e-01 0.107 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.823027e-01 0.107 0 0
Activation of RAC1 R-HSA-428540 7.823027e-01 0.107 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.823027e-01 0.107 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.823027e-01 0.107 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.823027e-01 0.107 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.823027e-01 0.107 0 0
Plasmalogen biosynthesis R-HSA-75896 7.823027e-01 0.107 0 0
ERKs are inactivated R-HSA-202670 7.823027e-01 0.107 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.823027e-01 0.107 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.823027e-01 0.107 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.855205e-01 0.105 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.929550e-01 0.101 0 0
Carnitine shuttle R-HSA-200425 7.929550e-01 0.101 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.929550e-01 0.101 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.929550e-01 0.101 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.929550e-01 0.101 0 0
Biosynthesis of maresins R-HSA-9018682 7.929550e-01 0.101 0 0
Interleukin-20 family signaling R-HSA-8854691 7.929550e-01 0.101 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.972061e-01 0.098 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.972061e-01 0.098 0 0
Diseases of DNA repair R-HSA-9675135 7.972061e-01 0.098 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.980017e-01 0.098 0 0
Transferrin endocytosis and recycling R-HSA-917977 7.988508e-01 0.098 0 0
tRNA processing R-HSA-72306 7.995880e-01 0.097 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.008579e-01 0.096 0 0
IRE1alpha activates chaperones R-HSA-381070 8.032440e-01 0.095 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.033527e-01 0.095 0 0
Repression of WNT target genes R-HSA-4641265 8.033527e-01 0.095 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.033527e-01 0.095 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.033527e-01 0.095 0 0
Signaling by LTK R-HSA-9842663 8.033527e-01 0.095 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.033527e-01 0.095 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.033527e-01 0.095 0 0
Synthesis of GDP-mannose R-HSA-446205 8.033527e-01 0.095 0 0
Regulation of IFNG signaling R-HSA-877312 8.033527e-01 0.095 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.033527e-01 0.095 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.033527e-01 0.095 0 0
OAS antiviral response R-HSA-8983711 8.033527e-01 0.095 0 0
Interleukin-35 Signalling R-HSA-8984722 8.033527e-01 0.095 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.033527e-01 0.095 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.081659e-01 0.092 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.081659e-01 0.092 0 0
Complex III assembly R-HSA-9865881 8.081659e-01 0.092 0 0
Extension of Telomeres R-HSA-180786 8.092345e-01 0.092 0 0
RUNX2 regulates bone development R-HSA-8941326 8.114798e-01 0.091 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.133532e-01 0.090 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.154233e-01 0.089 0 0
Metal ion SLC transporters R-HSA-425410 8.193378e-01 0.087 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.223685e-01 0.085 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.223685e-01 0.085 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.223685e-01 0.085 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.223685e-01 0.085 0 0
Interleukin-6 signaling R-HSA-1059683 8.223685e-01 0.085 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.223685e-01 0.085 0 0
Maturation of nucleoprotein R-HSA-9683610 8.223685e-01 0.085 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.223685e-01 0.085 0 0
G protein gated Potassium channels R-HSA-1296059 8.223724e-01 0.085 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.223724e-01 0.085 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.223724e-01 0.085 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.223724e-01 0.085 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.223724e-01 0.085 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.223724e-01 0.085 0 0
Laminin interactions R-HSA-3000157 8.223724e-01 0.085 0 0
Hyaluronan degradation R-HSA-2160916 8.223724e-01 0.085 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.285165e-01 0.082 0 0
Aquaporin-mediated transport R-HSA-445717 8.285165e-01 0.082 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.295580e-01 0.081 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.347289e-01 0.078 0 0
MET activates PTK2 signaling R-HSA-8874081 8.356264e-01 0.078 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.356264e-01 0.078 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.356264e-01 0.078 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.356264e-01 0.078 0 0
TRP channels R-HSA-3295583 8.356264e-01 0.078 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.375470e-01 0.077 0 0
Signaling by FGFR in disease R-HSA-1226099 8.379140e-01 0.077 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.395464e-01 0.076 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.395464e-01 0.076 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.395464e-01 0.076 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.395464e-01 0.076 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.395464e-01 0.076 0 0
Hydrolysis of LPC R-HSA-1483115 8.395464e-01 0.076 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.395464e-01 0.076 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.395464e-01 0.076 0 0
cGMP effects R-HSA-418457 8.395464e-01 0.076 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.395464e-01 0.076 0 0
Prolactin receptor signaling R-HSA-1170546 8.395464e-01 0.076 0 0
Malate-aspartate shuttle R-HSA-9856872 8.395464e-01 0.076 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.395464e-01 0.076 0 0
Regulation of KIT signaling R-HSA-1433559 8.395464e-01 0.076 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.395464e-01 0.076 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.395464e-01 0.076 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.395464e-01 0.076 0 0
SLC transporter disorders R-HSA-5619102 8.409496e-01 0.075 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.453983e-01 0.073 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.453983e-01 0.073 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.479792e-01 0.072 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.479792e-01 0.072 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.526448e-01 0.069 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.550640e-01 0.068 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.550640e-01 0.068 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.550640e-01 0.068 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.550640e-01 0.068 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.550640e-01 0.068 0 0
Other semaphorin interactions R-HSA-416700 8.550640e-01 0.068 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.550640e-01 0.068 0 0
DNA Damage Reversal R-HSA-73942 8.550640e-01 0.068 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.554642e-01 0.068 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.554642e-01 0.068 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.576297e-01 0.067 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.576297e-01 0.067 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.578854e-01 0.067 0 0
Interferon gamma signaling R-HSA-877300 8.579151e-01 0.067 1 1
Signaling by NTRKs R-HSA-166520 8.593565e-01 0.066 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.594812e-01 0.066 0 0
Prednisone ADME R-HSA-9757110 8.594812e-01 0.066 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.594812e-01 0.066 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.649520e-01 0.063 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.660467e-01 0.062 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.664717e-01 0.062 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.666948e-01 0.062 0 0
FOXO-mediated transcription R-HSA-9614085 8.686530e-01 0.061 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.690818e-01 0.061 0 0
Killing mechanisms R-HSA-9664420 8.690818e-01 0.061 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.690818e-01 0.061 0 0
Fructose catabolism R-HSA-70350 8.690818e-01 0.061 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.690818e-01 0.061 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.690818e-01 0.061 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.690818e-01 0.061 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.690818e-01 0.061 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.690818e-01 0.061 0 0
Virus Assembly and Release R-HSA-168268 8.690818e-01 0.061 0 0
mRNA Capping R-HSA-72086 8.701813e-01 0.060 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.738870e-01 0.059 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.801270e-01 0.055 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.801270e-01 0.055 0 0
Neurotransmitter clearance R-HSA-112311 8.801270e-01 0.055 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.817445e-01 0.055 0 0
Fibronectin matrix formation R-HSA-1566977 8.817445e-01 0.055 0 0
Coenzyme A biosynthesis R-HSA-196783 8.817445e-01 0.055 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.817445e-01 0.055 0 0
Regulated Necrosis R-HSA-5218859 8.838375e-01 0.054 0 0
Protein localization R-HSA-9609507 8.840318e-01 0.054 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.877148e-01 0.052 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.893641e-01 0.051 0 0
Signaling by SCF-KIT R-HSA-1433557 8.901980e-01 0.051 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.918774e-01 0.050 0 0
Neddylation R-HSA-8951664 8.922521e-01 0.050 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.931832e-01 0.049 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.931832e-01 0.049 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 8.931832e-01 0.049 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.931832e-01 0.049 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.931832e-01 0.049 0 0
Choline catabolism R-HSA-6798163 8.931832e-01 0.049 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.931832e-01 0.049 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.931832e-01 0.049 0 0
Amine ligand-binding receptors R-HSA-375280 8.976230e-01 0.047 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.979366e-01 0.047 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.979366e-01 0.047 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.979366e-01 0.047 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.019882e-01 0.045 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.035160e-01 0.044 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.035160e-01 0.044 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.035160e-01 0.044 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.035160e-01 0.044 0 0
Apoptotic factor-mediated response R-HSA-111471 9.035160e-01 0.044 0 0
Tie2 Signaling R-HSA-210993 9.035160e-01 0.044 0 0
Somitogenesis R-HSA-9824272 9.045927e-01 0.044 0 0
Triglyceride metabolism R-HSA-8979227 9.080588e-01 0.042 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.111304e-01 0.040 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.128498e-01 0.040 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.128498e-01 0.040 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.128498e-01 0.040 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.128498e-01 0.040 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.128498e-01 0.040 0 0
Maturation of nucleoprotein R-HSA-9694631 9.128498e-01 0.040 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.128498e-01 0.040 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.132542e-01 0.039 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.132542e-01 0.039 0 0
Heme degradation R-HSA-189483 9.132542e-01 0.039 0 0
GABA receptor activation R-HSA-977443 9.137931e-01 0.039 0 0
tRNA Aminoacylation R-HSA-379724 9.137931e-01 0.039 0 0
Mitochondrial biogenesis R-HSA-1592230 9.144346e-01 0.039 0 0
Gastrulation R-HSA-9758941 9.152489e-01 0.038 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.172584e-01 0.038 0 0
Immune System R-HSA-168256 9.184888e-01 0.037 1 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.200778e-01 0.036 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.200778e-01 0.036 0 0
Hyaluronan metabolism R-HSA-2142845 9.200778e-01 0.036 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.200778e-01 0.036 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.200778e-01 0.036 0 0
Infectious disease R-HSA-5663205 9.205776e-01 0.036 0 0
Hemostasis R-HSA-109582 9.209484e-01 0.036 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.212812e-01 0.036 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.212812e-01 0.036 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.212812e-01 0.036 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.212812e-01 0.036 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.212812e-01 0.036 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.212812e-01 0.036 0 0
Signaling by NODAL R-HSA-1181150 9.212812e-01 0.036 0 0
Creatine metabolism R-HSA-71288 9.212812e-01 0.036 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.212812e-01 0.036 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.212812e-01 0.036 0 0
Signaling by PDGF R-HSA-186797 9.243127e-01 0.034 0 0
Mitochondrial protein import R-HSA-1268020 9.243127e-01 0.034 0 0
Heme signaling R-HSA-9707616 9.243127e-01 0.034 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.253594e-01 0.034 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.263935e-01 0.033 0 0
Signalling to ERKs R-HSA-187687 9.263935e-01 0.033 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.288973e-01 0.032 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.288973e-01 0.032 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.288973e-01 0.032 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.288973e-01 0.032 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.288973e-01 0.032 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.288973e-01 0.032 0 0
GPVI-mediated activation cascade R-HSA-114604 9.322358e-01 0.030 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.322358e-01 0.030 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.322358e-01 0.030 0 0
Azathioprine ADME R-HSA-9748787 9.333984e-01 0.030 0 0
Parasitic Infection Pathways R-HSA-9824443 9.352516e-01 0.029 0 0
Leishmania infection R-HSA-9658195 9.352516e-01 0.029 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.357770e-01 0.029 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.357770e-01 0.029 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.357770e-01 0.029 0 0
Serine metabolism R-HSA-977347 9.357770e-01 0.029 0 0
Glutathione synthesis and recycling R-HSA-174403 9.357770e-01 0.029 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.357770e-01 0.029 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.357770e-01 0.029 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.357770e-01 0.029 0 0
Voltage gated Potassium channels R-HSA-1296072 9.376371e-01 0.028 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.376371e-01 0.028 0 0
The phototransduction cascade R-HSA-2514856 9.380980e-01 0.028 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.419541e-01 0.026 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.419914e-01 0.026 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.419914e-01 0.026 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.419914e-01 0.026 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.419914e-01 0.026 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.419914e-01 0.026 0 0
Fructose metabolism R-HSA-5652084 9.419914e-01 0.026 0 0
Ethanol oxidation R-HSA-71384 9.419914e-01 0.026 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.419914e-01 0.026 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.419914e-01 0.026 0 0
G alpha (i) signalling events R-HSA-418594 9.420760e-01 0.026 1 0
Kidney development R-HSA-9830369 9.457349e-01 0.024 0 0
Nucleotide biosynthesis R-HSA-8956320 9.465898e-01 0.024 0 0
Pentose phosphate pathway R-HSA-71336 9.472375e-01 0.024 0 0
Signaling by ALK R-HSA-201556 9.472375e-01 0.024 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.472375e-01 0.024 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.476048e-01 0.023 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.476048e-01 0.023 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.476048e-01 0.023 0 0
Formation of the ureteric bud R-HSA-9830674 9.476048e-01 0.023 0 0
Growth hormone receptor signaling R-HSA-982772 9.476048e-01 0.023 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.479161e-01 0.023 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.514924e-01 0.022 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.520272e-01 0.021 0 0
Mitochondrial protein degradation R-HSA-9837999 9.520272e-01 0.021 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.526753e-01 0.021 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.526753e-01 0.021 0 0
Interleukin-6 family signaling R-HSA-6783589 9.526753e-01 0.021 0 0
Maturation of spike protein R-HSA-9694548 9.554183e-01 0.020 0 0
COPII-mediated vesicle transport R-HSA-204005 9.557642e-01 0.020 0 0
Leishmania phagocytosis R-HSA-9664417 9.563742e-01 0.019 0 0
Parasite infection R-HSA-9664407 9.563742e-01 0.019 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.563742e-01 0.019 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.572553e-01 0.019 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.572553e-01 0.019 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.572553e-01 0.019 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.572553e-01 0.019 0 0
Formation of the nephric duct R-HSA-9830364 9.572553e-01 0.019 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.575654e-01 0.019 0 0
ECM proteoglycans R-HSA-3000178 9.587075e-01 0.018 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.590390e-01 0.018 0 0
Potassium Channels R-HSA-1296071 9.599479e-01 0.018 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.613924e-01 0.017 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.613924e-01 0.017 0 0
Urea cycle R-HSA-70635 9.613924e-01 0.017 0 0
Abacavir ADME R-HSA-2161522 9.613924e-01 0.017 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.623767e-01 0.017 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.636280e-01 0.016 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.651293e-01 0.015 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.651293e-01 0.015 0 0
Regulation of beta-cell development R-HSA-186712 9.659962e-01 0.015 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.659962e-01 0.015 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.661967e-01 0.015 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.664844e-01 0.015 0 0
Surfactant metabolism R-HSA-5683826 9.682852e-01 0.014 0 0
DAP12 interactions R-HSA-2172127 9.682852e-01 0.014 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.684990e-01 0.014 0 0
Telomere Extension By Telomerase R-HSA-171319 9.685046e-01 0.014 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.685046e-01 0.014 0 0
Pyrimidine salvage R-HSA-73614 9.685046e-01 0.014 0 0
Pyroptosis R-HSA-5620971 9.685046e-01 0.014 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.687576e-01 0.014 0 0
Formation of the cornified envelope R-HSA-6809371 9.692477e-01 0.014 0 0
G alpha (s) signalling events R-HSA-418555 9.706823e-01 0.013 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.715535e-01 0.013 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.715535e-01 0.013 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.715535e-01 0.013 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.715535e-01 0.013 0 0
DAP12 signaling R-HSA-2424491 9.743073e-01 0.011 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.743073e-01 0.011 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.743073e-01 0.011 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.747307e-01 0.011 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.750029e-01 0.011 0 0
Extracellular matrix organization R-HSA-1474244 9.757220e-01 0.011 0 0
Post-translational protein modification R-HSA-597592 9.766078e-01 0.010 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.767947e-01 0.010 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.767947e-01 0.010 0 0
Signaling by Insulin receptor R-HSA-74752 9.772148e-01 0.010 0 0
Peptide hormone metabolism R-HSA-2980736 9.788050e-01 0.009 0 0
DAG1 glycosylations R-HSA-8931838 9.790415e-01 0.009 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.791497e-01 0.009 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.794033e-01 0.009 0 0
PI3K Cascade R-HSA-109704 9.811204e-01 0.008 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.811204e-01 0.008 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.829037e-01 0.007 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.829037e-01 0.007 0 0
eNOS activation R-HSA-203615 9.845593e-01 0.007 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.845593e-01 0.007 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.860546e-01 0.006 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.860546e-01 0.006 0 0
Metabolism of porphyrins R-HSA-189445 9.866786e-01 0.006 0 0
HS-GAG biosynthesis R-HSA-2022928 9.874052e-01 0.006 0 0
NCAM1 interactions R-HSA-419037 9.886250e-01 0.005 0 0
Lysine catabolism R-HSA-71064 9.886250e-01 0.005 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.897268e-01 0.004 0 0
Purine salvage R-HSA-74217 9.897268e-01 0.004 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.897268e-01 0.004 0 0
IRS-mediated signalling R-HSA-112399 9.897957e-01 0.004 0 0
Neurotransmitter release cycle R-HSA-112310 9.902511e-01 0.004 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.907219e-01 0.004 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.916207e-01 0.004 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.916207e-01 0.004 0 0
Tryptophan catabolism R-HSA-71240 9.916207e-01 0.004 0 0
RAB geranylgeranylation R-HSA-8873719 9.921835e-01 0.003 0 0
Metabolism of polyamines R-HSA-351202 9.921835e-01 0.003 0 0
Adipogenesis R-HSA-9843745 9.922494e-01 0.003 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.924325e-01 0.003 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.928505e-01 0.003 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.930141e-01 0.003 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.931656e-01 0.003 0 0
HIV Transcription Initiation R-HSA-167161 9.931656e-01 0.003 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.931656e-01 0.003 0 0
Intra-Golgi traffic R-HSA-6811438 9.931656e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.931656e-01 0.003 0 0
Heme biosynthesis R-HSA-189451 9.931656e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.933183e-01 0.003 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.934618e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.935934e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.935934e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.938278e-01 0.003 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.940683e-01 0.003 0 0
GPCR downstream signalling R-HSA-388396 9.941876e-01 0.003 1 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.944259e-01 0.002 0 0
Insulin receptor signalling cascade R-HSA-74751 9.945346e-01 0.002 0 0
IGF1R signaling cascade R-HSA-2428924 9.945346e-01 0.002 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.946880e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.949660e-01 0.002 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.949676e-01 0.002 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.950043e-01 0.002 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.954538e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.954538e-01 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.957852e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.959325e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.963863e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.966517e-01 0.001 0 0
PI Metabolism R-HSA-1483255 9.966620e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.968192e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.969762e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.970951e-01 0.001 0 0
Metabolism of proteins R-HSA-392499 9.972447e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.974126e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.975340e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.975780e-01 0.001 0 0
Disease R-HSA-1643685 9.979181e-01 0.001 1 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.979817e-01 0.001 0 0
Glucuronidation R-HSA-156588 9.981840e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.983588e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.983601e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.984660e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.984660e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.984660e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.986279e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.986627e-01 0.001 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.988354e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.988906e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.989095e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.989095e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.990153e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.990784e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.991108e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.991108e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.992691e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.992749e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.992749e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.993453e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.995180e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.995180e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.995647e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.995787e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.996378e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.996815e-01 0.000 1 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.996818e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997107e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.997107e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.997811e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998039e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.998044e-01 0.000 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.998432e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.998584e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.998692e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998866e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999076e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999151e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999375e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999414e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999559e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999724e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999726e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999757e-01 0.000 1 0
Mitochondrial translation R-HSA-5368287 9.999808e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999894e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999910e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999922e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999948e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999951e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999957e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999964e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999971e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999976e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999976e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999987e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999990e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999992e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999995e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999995e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999995e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999996e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999997e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999998e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phospholipid metabolism R-HSA-1483257 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways