TTK

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
O14950	T160	Sugiyama	MYL12B MRLC2 MYLC2B	DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
O14979	T165	Sugiyama	HNRNPDL HNRPDL JKTBP	QDDGKMFIGGLSWDTsKKDLtEyLSRFGEVVDCtIKTDPVT
O60566	S1043	EPSD\|PSP	BUB1B BUBR1 MAD3L SSK1	FDTTFQSHLNKALWKVGKLtsPGALLFQ_____________
O60566	S435	EPSD\|PSP	BUB1B BUBR1 MAD3L SSK1	IRAEVFRKKLKEQREAELLtsAEKRAEMQKQIEEMEKKLKE
O60566	S543	EPSD\|PSP	BUB1B BUBR1 MAD3L SSK1	GPsVPFSIFDEFLLSEKKNKsPPADPPRVLAQRRPLAVLKt
O60566	S670	EPSD\|PSP	BUB1B BUBR1 MAD3L SSK1	EDQQTACGtIysQtLsIKKLsPIIEDsREAtHSsGFsGSSA
O96017	T68	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CHEK2 CDS1 CHK2 RAD53	NSsQSSHSSSGTLSsLETVStQELYsIPEDQEPEDQEPEEP
P00519	T735	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	ABL1 ABL JTK7	RsCsAsCVPHGAKDTEWRSVtLPRDLQStGRQFDSstFGGH
P04637	T18	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	TP53 P53	___MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQ
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06733	T19	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	__MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGA
P06733	T26	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P07900	T115	EPSD\|PSP	HSP90AA1 HSP90A HSPC1 HSPCA	GIGMTKADLINNLGtIAKSGtKAFMEALQAGADISMIGQFG
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P19105	T159	Sugiyama	MYL12A MLCB MRLC3 RLC	DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27816	S928	SIGNOR\|PSP	MAP4	PTSAKPssttPRLSRLAtNtsAPDLKNVRsKVGstENIKHQ
P27816	T927	SIGNOR\|PSP	MAP4	KPTSAKPssttPRLSRLAtNtsAPDLKNVRsKVGstENIKH
P30305	S169	ELM	CDC25B CDC25HU2	FQsMPVRLLGHsPVLRNItNsQAPDGRRKsEAGSGAAssSG
P30305	S323	ELM	CDC25B CDC25HU2	KEEEKDLVMYSKCQRLFRsPsMPCSVIRPILKRLERPQDRD
P33981	S15	EPSD\|PSP\|Sugiyama	TTK MPS1 MPS1L1	______MESEDLsGRELtIDsIMNKVRDIKNKFKNEDLtDE
P33981	S214	SIGNOR	TTK MPS1 MPS1L1	LLSEEEKKNLSASTVLtAQEsFSGSLGHLQNRNNSCDSRGQ
P33981	S321	SIGNOR\|PSP\|Sugiyama	TTK MPS1 MPS1L1	TSRSECRDLVVPGSKPsGNDsCELRNLKSVQNsHFKEPLVS
P33981	S362	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	DEKsSELIITDSITLKNKtEssLLAKLEEtKEyQEPEVPEs
P33981	S363	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	EKsSELIITDSITLKNKtEssLLAKLEEtKEyQEPEVPEsN
P33981	S37	SIGNOR\|EPSD\|PSP\|Sugiyama	TTK MPS1 MPS1L1	MNKVRDIKNKFKNEDLtDELsLNKIsADttDNsGtVNQIMM
P33981	S436	EPSD\|PSP	TTK MPS1 MPS1L1	VNTEQKHTTFEQPVFSVSKQsPPISTSKWFDPKSICKtPss
P33981	S49	PSP	TTK MPS1 MPS1L1	NEDLtDELsLNKIsADttDNsGtVNQIMMMANNPEDWLSLL
P33981	S582	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	NQtLDSYRNEIAYLNKLQQHsDKIIRLYDYEItDQYIYMVM
P33981	S677	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	DGMLKLIDFGIANQMQPDttsVVKDSQVGtVNYMPPEAIKD
P33981	S7	PSP	TTK MPS1 MPS1L1	______________MESEDLsGRELtIDsIMNKVRDIKNKF
P33981	S742	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	CILYYMTYGKTPFQQIINQIsKLHAIIDPNHEIEFPDIPEK
P33981	S80	EPSD\|PSP\|Sugiyama	TTK MPS1 MPS1L1	NNPEDWLSLLLKLEKNSVPLsDALLNKLIGRYSQAIEALPP
P33981	S821	EPSD\|PSP	TTK MPS1 MPS1L1	MAKGttEEMKyVLGQLVGLNsPNsILKAAKTLyEHYsGGES
P33981	S824	EPSD\|PSP	TTK MPS1 MPS1L1	GttEEMKyVLGQLVGLNsPNsILKAAKTLyEHYsGGESHNs
P33981	S844	Sugiyama	TTK MPS1 MPS1L1	sILKAAKTLyEHYsGGESHNssssKtFEKKRGKK_______
P33981	S845	EPSD\|PSP	TTK MPS1 MPS1L1	ILKAAKTLyEHYsGGESHNssssKtFEKKRGKK________
P33981	S847	EPSD\|PSP	TTK MPS1 MPS1L1	KAAKTLyEHYsGGESHNssssKtFEKKRGKK__________
P33981	T12	SIGNOR\|EPSD\|PSP\|Sugiyama	TTK MPS1 MPS1L1	_________MESEDLsGRELtIDsIMNKVRDIKNKFKNEDL
P33981	T288	EPSD\|PSP	TTK MPS1 MPS1L1	SCPFGRVPVNLLNsPDCDVKtDDsVVPCFMKRQTSRSECRD
P33981	T33	SIGNOR\|EPSD\|PSP\|Sugiyama	TTK MPS1 MPS1L1	IDsIMNKVRDIKNKFKNEDLtDELsLNKIsADttDNsGtVN
P33981	T360	EPSD\|PSP	TTK MPS1 MPS1L1	VSDEKsSELIITDSITLKNKtEssLLAKLEEtKEyQEPEVP
P33981	T371	SIGNOR\|PSP	TTK MPS1 MPS1L1	TDSITLKNKtEssLLAKLEEtKEyQEPEVPEsNQKQWQSKR
P33981	T45	PSP	TTK MPS1 MPS1L1	NKFKNEDLtDELsLNKIsADttDNsGtVNQIMMMANNPEDW
P33981	T46	PSP	TTK MPS1 MPS1L1	KFKNEDLtDELsLNKIsADttDNsGtVNQIMMMANNPEDWL
P33981	T564	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	NEKKQIYAIKYVNLEEADNQtLDSYRNEIAYLNKLQQHsDK
P33981	T675	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	IVDGMLKLIDFGIANQMQPDttsVVKDSQVGtVNYMPPEAI
P33981	T676	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TTK MPS1 MPS1L1	VDGMLKLIDFGIANQMQPDttsVVKDSQVGtVNYMPPEAIK
P33981	T686	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TTK MPS1 MPS1L1	GIANQMQPDttsVVKDSQVGtVNYMPPEAIKDMSSSRENGK
P33981	T795	EPSD\|PSP	TTK MPS1 MPS1L1	DPKQRISIPELLAHPYVQIQtHPVNQMAKGttEEMKyVLGQ
P33981	T805	EPSD\|PSP	TTK MPS1 MPS1L1	LLAHPYVQIQtHPVNQMAKGttEEMKyVLGQLVGLNsPNsI
P33981	T806	SIGNOR\|EPSD\|PSP	TTK MPS1 MPS1L1	LAHPYVQIQtHPVNQMAKGttEEMKyVLGQLVGLNsPNsIL
P33981	T849	EPSD\|PSP	TTK MPS1 MPS1L1	AKTLyEHYsGGESHNssssKtFEKKRGKK____________
P33981	Y811	EPSD\|PSP	TTK MPS1 MPS1L1	VQIQtHPVNQMAKGttEEMKyVLGQLVGLNsPNsILKAAKT
P35221	S641	Sugiyama	CTNNA1	GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P38646	S65	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	HSPA9 GRP75 HSPA9B mt-HSP70	DyASEAIKGAVVGIDLGtTNsCVAVMEGKQAKVLENAEGAR
P38646	T62	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	HSPA9 GRP75 HSPA9B mt-HSP70	SRRDyASEAIKGAVVGIDLGtTNsCVAVMEGKQAKVLENAE
P54132	S1290	EPSD\|PSP	BLM RECQ2 RECQL3	KLEKYGAEVIsVLQKYSEWTsPAEDssPGIsLsSSRGPGRs
P54132	S1296	EPSD\|PSP	BLM RECQ2 RECQL3	AEVIsVLQKYSEWTsPAEDssPGIsLsSSRGPGRsAAEELD
P54132	S144	EPSD\|PSP	BLM RECQ2 RECQL3	NtPtVKKSRDTALKKLEFsssPDsLstINDWDDMDDFDTSE
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62424	T84	Sugiyama	RPL7A SURF-3 SURF3	QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62899	T26	Sugiyama	RPL31	KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P84098	T29	Sugiyama	RPL19	RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q14247	T328	Sugiyama	CTTN EMS1	GKyGVQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKts
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q53HL2	S238	GPS6\|EPSD\|PSP	CDCA8 PESCRG3	GsPLADsKEIFLtVPVGGGEsLRLLAsDLQRHsIAQLDPEA
Q53HL2	T169	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDCA8 PESCRG3	KKRTQsIQGKGKGKRSsRANtVTPAVGRLEVSMVKPTPGLT
Q53HL2	T230	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDCA8 PESCRG3	RIyNIsGNGsPLADsKEIFLtVPVGGGEsLRLLAsDLQRHs
Q53HL2	T88	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDCA8 PESCRG3	MNWLDYFALGGNKQALEEAAtADLDItEINKLTAEAIQtPL
Q53HL2	T94	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDCA8 PESCRG3	FALGGNKQALEEAAtADLDItEINKLTAEAIQtPLKsAKTR
Q6IBW4	S492	PSP	NCAPH2 CAPH2	RRNVELFIATSQKFVQETELsQRIRDWEDtVQPLLQEQEQH
Q96B36	T233	Sugiyama	AKT1S1 PRAS40	PDLDRIAAsMRALVLREAEDtQVFGDLPRPRLNtsDFQKLK
Q96E14	S112	EPSD\|PSP	RMI2 C16orf75	GRPCLVPGKYVMVMGVVQACsPEPCLQAVKMTDLSDNPIHE
Q96PE2	T1007	EPSD\|PSP	ARHGEF17 KIAA0337 TEM4	PIGFPTRAHPTLQAPsLEDVtKQYMLNLHSGEVPAPVPVDM
Q96PE2	T751	EPSD\|PSP	ARHGEF17 KIAA0337 TEM4	YRsLsDPIPQRHRAATSEEPtGFSVDSNLLGsLsPKTGLPA
Q96PE2	T944	EPSD\|PSP	ARHGEF17 KIAA0337 TEM4	KRPARSSHQELRRDEGSQDQtGsLSRARPSSRHVRHAsVPA
Q9BQ16	T118	Sugiyama	SPOCK3 TICN3 UNQ409/PRO771	HKVCIAQDSQTAVCISHRRLtHRMKEAGVDHRQWRGPILST
Q9H444	T103	Sugiyama	CHMP4B C20orf178 SHAX1	DGtLstIEFQREALENANtNtEVLKNMGYAAKAMKAAHDNM
Q9Y2T7	T143	Sugiyama	YBX2 CSDA3 MSY2	QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y5T5	S415	SIGNOR\|EPSD\|PSP	USP16 MSTP039	GKKSVNDKNLKKTVEDEDQDsEEEKDNDsYIKERSDIPSGT
Q9Y5T5	S552	EPSD\|PSP	USP16 MSTP039	TEEVDMKNINMDNDLEVLtssPtRNLNGAYLTEGSNGEVDI
Q9Y5T5	T554	SIGNOR\|EPSD\|PSP	USP16 MSTP039	EVDMKNINMDNDLEVLtssPtRNLNGAYLTEGSNGEVDISN
Q9Y6D9	S22	EPSD\|PSP	MAD1L1 MAD1 TXBP181	EDLGENtMVLSTLRsLNNFIsQRVEGGsGLDISTSAPGSLQ
Q9Y6D9	S598	EPSD\|PSP	MAD1L1 MAD1 TXBP181	MERGGTVPADLEAAAASLPSsKEVAELKKQVEsAELKNQRL
Q9Y6D9	S610	EPSD\|PSP	MAD1L1 MAD1 TXBP181	AAAASLPSsKEVAELKKQVEsAELKNQRLKEVFQtKIQEFR
Q9Y6D9	S62	EPSD\|PSP	MAD1L1 MAD1 TXBP181	QMQYQQSMQLEERAEQIRSKsHLIQVEREKMQMELsHKRAR
Q9Y6D9	T323	EPSD\|PSP	MAD1L1 MAD1 TXBP181	LELENERLLAKLQSWERLDQtMGLSIRTPEDLSRFVVELQQ
Q9Y6D9	T624	EPSD\|PSP	MAD1L1 MAD1 TXBP181	LKKQVEsAELKNQRLKEVFQtKIQEFRKACyTLTGYQIDIT
Q9Y6D9	T716	EPSD\|PSP	MAD1L1 MAD1 TXBP181	RQDsIPAFLSSLtLELFSRQtVA__________________
Q9Y6D9	T8	EPSD\|PSP	MAD1L1 MAD1 TXBP181	_____________MEDLGENtMVLSTLRsLNNFIsQRVEGG
Q9Y6R1	S12	PSP	SLC4A4 NBC NBC1 NBCE1	_________MEDEAVLDRGAsFLKHVCDEEEVEGHHTIYIG

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Nuclear Receptor transcription pathway	R-HSA-383280	1.027584e-07	6.988
Signaling by ERBB2	R-HSA-1227986	1.464327e-07	6.834
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.805273e-06	5.420
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.804332e-06	5.236
Cell Cycle	R-HSA-1640170	9.520482e-06	5.021
Apoptotic execution phase	R-HSA-75153	1.372160e-05	4.863
Signal Transduction	R-HSA-162582	2.536895e-05	4.596
Cellular responses to stimuli	R-HSA-8953897	7.212533e-05	4.142
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	1.891845e-04	3.723
DNA Double-Strand Break Repair	R-HSA-5693532	2.084942e-04	3.681
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.473008e-04	3.607
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.487595e-04	3.457
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.504640e-04	3.455
Signaling by ALK in cancer	R-HSA-9700206	3.504640e-04	3.455
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	5.763169e-04	3.239
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	5.763169e-04	3.239
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	5.763169e-04	3.239
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	5.763169e-04	3.239
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	5.763169e-04	3.239
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	5.763169e-04	3.239
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	5.763169e-04	3.239
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	5.763169e-04	3.239
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	5.763169e-04	3.239
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	5.763169e-04	3.239
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	5.763169e-04	3.239
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	4.852068e-04	3.314
Signaling by VEGF	R-HSA-194138	5.717351e-04	3.243
Cellular responses to stress	R-HSA-2262752	5.260210e-04	3.279
Unfolded Protein Response (UPR)	R-HSA-381119	6.038130e-04	3.219
Signaling by ERBB2 in Cancer	R-HSA-1227990	6.545198e-04	3.184
DNA Repair	R-HSA-73894	7.068506e-04	3.151
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	7.516258e-04	3.124
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	8.981773e-04	3.047
Cell Cycle Checkpoints	R-HSA-69620	8.723317e-04	3.059
Activation of ATR in response to replication stress	R-HSA-176187	1.037025e-03	2.984
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.031594e-03	2.986
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.040826e-03	2.983
Nuclear Envelope Breakdown	R-HSA-2980766	1.297868e-03	2.887
Cell Cycle, Mitotic	R-HSA-69278	1.286375e-03	2.891
M Phase	R-HSA-68886	1.692330e-03	2.772
XBP1(S) activates chaperone genes	R-HSA-381038	1.644690e-03	2.784
Regulation of PTEN gene transcription	R-HSA-8943724	1.758733e-03	2.755
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.968495e-03	2.706
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.968495e-03	2.706
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.958105e-03	2.708
EPHA-mediated growth cone collapse	R-HSA-3928663	2.192568e-03	2.659
Axon guidance	R-HSA-422475	2.220164e-03	2.654
Semaphorin interactions	R-HSA-373755	2.342162e-03	2.630
Ephrin signaling	R-HSA-3928664	2.381365e-03	2.623
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.381365e-03	2.623
Metabolism of RNA	R-HSA-8953854	2.526210e-03	2.598
Homology Directed Repair	R-HSA-5693538	2.671878e-03	2.573
IRE1alpha activates chaperones	R-HSA-381070	2.622011e-03	2.581
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.923868e-03	2.534
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.923868e-03	2.534
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.996576e-03	2.523
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	3.153989e-03	2.501
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.351370e-03	2.475
Processing of DNA double-strand break ends	R-HSA-5693607	3.242123e-03	2.489
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.289515e-03	2.483
Downregulation of ERBB2 signaling	R-HSA-8863795	3.351370e-03	2.475
Gene expression (Transcription)	R-HSA-74160	3.435000e-03	2.464
Nervous system development	R-HSA-9675108	3.568272e-03	2.448
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	4.104830e-03	2.387
Negative feedback regulation of MAPK pathway	R-HSA-5674499	4.104830e-03	2.387
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.996122e-03	2.398
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.996122e-03	2.398
Signaling by LTK	R-HSA-9842663	3.959691e-03	2.402
Regulation of CDH19 Expression and Function	R-HSA-9764302	4.104830e-03	2.387
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	4.059841e-03	2.391
Signaling by SCF-KIT	R-HSA-1433557	4.553160e-03	2.342
G2/M Checkpoints	R-HSA-69481	4.873227e-03	2.312
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	4.675365e-03	2.330
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	4.914060e-03	2.309
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	4.953254e-03	2.305
HIV Infection	R-HSA-162906	5.084977e-03	2.294
Mitotic Prometaphase	R-HSA-68877	5.265479e-03	2.279
Signaling by LTK in cancer	R-HSA-9842640	5.678094e-03	2.246
RNA Polymerase II Pre-transcription Events	R-HSA-674695	5.897074e-03	2.229
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	6.216994e-03	2.206
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.216994e-03	2.206
Regulation of KIT signaling	R-HSA-1433559	5.966247e-03	2.224
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.216994e-03	2.206
ISG15 antiviral mechanism	R-HSA-1169408	6.358198e-03	2.197
Diseases of DNA repair	R-HSA-9675135	6.152442e-03	2.211
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	7.200579e-03	2.143
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	6.753089e-03	2.170
Mitotic Anaphase	R-HSA-68882	6.825083e-03	2.166
Mitotic Metaphase and Anaphase	R-HSA-2555396	7.109118e-03	2.148
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.955106e-03	2.158
Transcriptional Regulation by TP53	R-HSA-3700989	6.819991e-03	2.166
Co-stimulation by CD28	R-HSA-389356	7.429711e-03	2.129
Platelet activation, signaling and aggregation	R-HSA-76002	7.483507e-03	2.126
IFNG signaling activates MAPKs	R-HSA-9732724	7.567472e-03	2.121
Mitotic Prophase	R-HSA-68875	7.864255e-03	2.104
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.906329e-03	2.102
EPH-Ephrin signaling	R-HSA-2682334	8.132494e-03	2.090
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	8.927087e-03	2.049
Cellular response to heat stress	R-HSA-3371556	8.306613e-03	2.081
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	8.618326e-03	2.065
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	9.092588e-03	2.041
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.227021e-03	2.035
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.236689e-03	2.034
Signaling by EGFR in Cancer	R-HSA-1643713	9.334626e-03	2.030
Myogenesis	R-HSA-525793	9.334626e-03	2.030
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	9.548832e-03	2.020
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.072717e-02	1.970
Intracellular signaling by second messengers	R-HSA-9006925	1.050859e-02	1.978
Ub-specific processing proteases	R-HSA-5689880	1.049466e-02	1.979
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.054953e-02	1.977
HIV Life Cycle	R-HSA-162587	1.089732e-02	1.963
Transcription of the HIV genome	R-HSA-167172	1.153582e-02	1.938
Late Phase of HIV Life Cycle	R-HSA-162599	1.231714e-02	1.909
Signaling by Hippo	R-HSA-2028269	1.178676e-02	1.929
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.234595e-02	1.908
Inactivation of CDC42 and RAC1	R-HSA-428543	1.234595e-02	1.908
GP1b-IX-V activation signalling	R-HSA-430116	1.234595e-02	1.908
Chromatin organization	R-HSA-4839726	1.180566e-02	1.928
RNA Polymerase II Transcription	R-HSA-73857	1.224763e-02	1.912
Cellular responses to mechanical stimuli	R-HSA-9855142	1.265593e-02	1.898
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.329483e-02	1.876
MAP2K and MAPK activation	R-HSA-5674135	1.399112e-02	1.854
Signaling by RAF1 mutants	R-HSA-9656223	1.399112e-02	1.854
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	1.430824e-02	1.844
Chromatin modifying enzymes	R-HSA-3247509	1.358185e-02	1.867
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.365959e-02	1.865
Apoptosis	R-HSA-109581	1.358811e-02	1.867
Cytokine Signaling in Immune system	R-HSA-1280215	1.432149e-02	1.844
Signaling by EGFR	R-HSA-177929	1.454780e-02	1.837
Signaling by FGFR1	R-HSA-5654736	1.454780e-02	1.837
Extra-nuclear estrogen signaling	R-HSA-9009391	1.475546e-02	1.831
ESR-mediated signaling	R-HSA-8939211	1.509724e-02	1.821
Interleukin-12 family signaling	R-HSA-447115	1.520329e-02	1.818
Regulation of CDH11 function	R-HSA-9762292	1.525335e-02	1.817
Signal attenuation	R-HSA-74749	1.525335e-02	1.817
PI Metabolism	R-HSA-1483255	1.559019e-02	1.807
Regulation of CDH1 Function	R-HSA-9764561	1.569333e-02	1.804
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.571136e-02	1.804
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.851401e-02	1.732
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.851401e-02	1.732
Signaling by FGFR4	R-HSA-5654743	1.667921e-02	1.778
G2/M DNA damage checkpoint	R-HSA-69473	1.735863e-02	1.760
Response of endothelial cells to shear stress	R-HSA-9860931	1.736427e-02	1.760
PECAM1 interactions	R-HSA-210990	1.851401e-02	1.732
Programmed Cell Death	R-HSA-5357801	1.866028e-02	1.729
Nucleotide Excision Repair	R-HSA-5696398	1.928314e-02	1.715
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.969322e-02	1.706
Interleukin-12 signaling	R-HSA-9020591	1.970019e-02	1.706
Signaling by FGFR3	R-HSA-5654741	1.970338e-02	1.705
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.988858e-02	1.701
Integrin signaling	R-HSA-354192	2.014720e-02	1.696
SARS-CoV-1-host interactions	R-HSA-9692914	2.029883e-02	1.693
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.384728e-02	1.623
Signaling by MAP2K mutants	R-HSA-9652169	2.384728e-02	1.623
Signaling downstream of RAS mutants	R-HSA-9649948	2.134684e-02	1.671
mRNA Splicing - Major Pathway	R-HSA-72163	2.396832e-02	1.620
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.134684e-02	1.671
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.134684e-02	1.671
PTEN Regulation	R-HSA-6807070	2.288912e-02	1.640
Signaling by RAS mutants	R-HSA-6802949	2.134684e-02	1.671
Eukaryotic Translation Elongation	R-HSA-156842	2.145903e-02	1.668
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	2.213084e-02	1.655
Signaling by NTRK3 (TRKC)	R-HSA-9034015	2.298649e-02	1.639
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.358011e-02	1.627
GPER1 signaling	R-HSA-9634597	2.490639e-02	1.604
Signaling by Interleukins	R-HSA-449147	2.527056e-02	1.597
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	2.579725e-02	1.588
Signaling by KIT in disease	R-HSA-9669938	2.579725e-02	1.588
SHC-related events triggered by IGF1R	R-HSA-2428933	2.610471e-02	1.583
Regulation of TP53 Activity	R-HSA-5633007	2.648376e-02	1.577
Signalling to ERKs	R-HSA-187687	2.657482e-02	1.576
Oncogene Induced Senescence	R-HSA-2559585	2.657482e-02	1.576
Degradation of CDH1	R-HSA-9766229	2.682613e-02	1.571
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.724328e-02	1.565
PIP3 activates AKT signaling	R-HSA-1257604	2.726262e-02	1.564
HSF1 activation	R-HSA-3371511	2.897631e-02	1.538
RET signaling	R-HSA-8853659	2.897631e-02	1.538
Formation of RNA Pol II elongation complex	R-HSA-112382	3.316483e-02	1.479
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.483458e-02	1.458
Amplification of signal from the kinetochores	R-HSA-141424	3.483458e-02	1.458
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	3.276341e-02	1.485
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.132269e-02	1.504
Mitotic Spindle Checkpoint	R-HSA-69618	3.402267e-02	1.468
Oncogenic MAPK signaling	R-HSA-6802957	3.304688e-02	1.481
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.163818e-02	1.500
Interleukin-6 signaling	R-HSA-1059683	3.043459e-02	1.517
HATs acetylate histones	R-HSA-3214847	3.242225e-02	1.489
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	3.163818e-02	1.500
Signaling by NTRKs	R-HSA-166520	3.429193e-02	1.465
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	3.043459e-02	1.517
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	3.316483e-02	1.479
mRNA Splicing	R-HSA-72172	3.484795e-02	1.458
NRIF signals cell death from the nucleus	R-HSA-205043	3.511780e-02	1.454
Interleukin-7 signaling	R-HSA-1266695	3.542289e-02	1.451
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.547570e-02	1.450
Smooth Muscle Contraction	R-HSA-445355	3.547570e-02	1.450
MAPK family signaling cascades	R-HSA-5683057	3.664768e-02	1.436
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	3.668663e-02	1.435
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.698466e-02	1.432
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	3.992695e-02	1.399
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	3.992695e-02	1.399
Aggrephagy	R-HSA-9646399	3.992695e-02	1.399
IRF3-mediated induction of type I IFN	R-HSA-3270619	4.015015e-02	1.396
Signaling by Activin	R-HSA-1502540	4.015015e-02	1.396
Spry regulation of FGF signaling	R-HSA-1295596	4.015015e-02	1.396
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.058696e-02	1.392
HIV elongation arrest and recovery	R-HSA-167287	4.686390e-02	1.329
Pausing and recovery of HIV elongation	R-HSA-167290	4.686390e-02	1.329
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	4.622719e-02	1.335
HIV Transcription Initiation	R-HSA-167161	4.622719e-02	1.335
RNA Polymerase II Transcription Initiation	R-HSA-75953	4.622719e-02	1.335
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	4.301913e-02	1.366
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	4.856651e-02	1.314
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.121768e-02	1.385
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	4.841141e-02	1.315
Neutrophil degranulation	R-HSA-6798695	4.181465e-02	1.379
Cellular response to starvation	R-HSA-9711097	4.925690e-02	1.308
Prolonged ERK activation events	R-HSA-169893	4.552610e-02	1.342
MAPK1/MAPK3 signaling	R-HSA-5684996	4.825884e-02	1.316
rRNA processing	R-HSA-72312	4.474269e-02	1.349
Autophagy	R-HSA-9612973	4.595866e-02	1.338
CD28 dependent PI3K/Akt signaling	R-HSA-389357	4.284782e-02	1.368
Deubiquitination	R-HSA-5688426	4.833150e-02	1.316
Signaling by ERBB4	R-HSA-1236394	4.593072e-02	1.338
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.686390e-02	1.329
Generic Transcription Pathway	R-HSA-212436	4.927970e-02	1.307
Ca-dependent events	R-HSA-111996	4.958647e-02	1.305
Host Interactions of HIV factors	R-HSA-162909	4.962869e-02	1.304
PTK6 promotes HIF1A stabilization	R-HSA-8857538	4.970188e-02	1.304
Nef and signal transduction	R-HSA-164944	4.970188e-02	1.304
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	4.970188e-02	1.304
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	7.572717e-02	1.121
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	7.572717e-02	1.121
Diseases of Telomere Maintenance	R-HSA-9673013	7.572717e-02	1.121
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	7.572717e-02	1.121
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	R-HSA-5619043	7.572717e-02	1.121
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	7.572717e-02	1.121
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	7.572717e-02	1.121
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	7.572717e-02	1.121
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	7.572717e-02	1.121
Hereditary fructose intolerance	R-HSA-5657560	7.572717e-02	1.121
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	7.572717e-02	1.121
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	7.572717e-02	1.121
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.982482e-02	1.223
RUNX3 regulates WNT signaling	R-HSA-8951430	5.982482e-02	1.223
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	5.982482e-02	1.223
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	5.982482e-02	1.223
Activated NTRK2 signals through FYN	R-HSA-9032500	7.058282e-02	1.151
Signaling by MRAS-complex mutants	R-HSA-9660537	7.058282e-02	1.151
Activation of RAS in B cells	R-HSA-1169092	7.058282e-02	1.151
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	7.058282e-02	1.151
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	8.191191e-02	1.087
MAPK1 (ERK2) activation	R-HSA-112411	8.191191e-02	1.087
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.031694e-02	1.153
Nephrin family interactions	R-HSA-373753	7.729134e-02	1.112
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.729134e-02	1.112
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.729134e-02	1.112
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.729134e-02	1.112
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.729134e-02	1.112
RNA Polymerase II Promoter Escape	R-HSA-73776	5.308571e-02	1.275
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	6.050425e-02	1.218
Metabolism of non-coding RNA	R-HSA-194441	5.149792e-02	1.288
snRNP Assembly	R-HSA-191859	5.149792e-02	1.288
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	6.428479e-02	1.192
Loss of Nlp from mitotic centrosomes	R-HSA-380259	6.428479e-02	1.192
AURKA Activation by TPX2	R-HSA-8854518	7.499264e-02	1.125
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.091940e-02	1.293
Formation of definitive endoderm	R-HSA-9823730	7.729134e-02	1.112
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	6.848113e-02	1.164
DNA Double Strand Break Response	R-HSA-5693606	7.877403e-02	1.104
ERK/MAPK targets	R-HSA-198753	8.455593e-02	1.073
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	8.172533e-02	1.088
EPHB-mediated forward signaling	R-HSA-3928662	5.672500e-02	1.246
Chaperone Mediated Autophagy	R-HSA-9613829	6.364343e-02	1.196
GAB1 signalosome	R-HSA-180292	6.364343e-02	1.196
DNA strand elongation	R-HSA-69190	6.493406e-02	1.188
Platelet Aggregation (Plug Formation)	R-HSA-76009	6.050425e-02	1.218
Cap-dependent Translation Initiation	R-HSA-72737	7.527421e-02	1.123
Eukaryotic Translation Initiation	R-HSA-72613	7.527421e-02	1.123
Separation of Sister Chromatids	R-HSA-2467813	6.011133e-02	1.221
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.493406e-02	1.188
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.364343e-02	1.196
Signaling by WNT in cancer	R-HSA-4791275	6.493406e-02	1.188
Meiosis	R-HSA-1500620	7.787998e-02	1.109
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	7.729134e-02	1.112
Recycling pathway of L1	R-HSA-437239	6.848113e-02	1.164
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	5.108180e-02	1.292
RAF/MAP kinase cascade	R-HSA-5673001	6.762743e-02	1.170
Co-stimulation by ICOS	R-HSA-9927354	7.058282e-02	1.151
Unwinding of DNA	R-HSA-176974	8.191191e-02	1.087
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.446310e-02	1.191
Rap1 signalling	R-HSA-392517	7.031694e-02	1.153
Regulation of signaling by CBL	R-HSA-912631	7.031694e-02	1.153
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.454437e-02	1.073
Signaling by NODAL	R-HSA-1181150	7.729134e-02	1.112
Regulated proteolysis of p75NTR	R-HSA-193692	8.191191e-02	1.087
Co-inhibition by CTLA4	R-HSA-389513	7.729134e-02	1.112
Signaling by FGFR2	R-HSA-5654738	6.207857e-02	1.207
L1CAM interactions	R-HSA-373760	7.527421e-02	1.123
Signaling by FGFR	R-HSA-190236	6.974185e-02	1.157
MAP kinase activation	R-HSA-450294	5.767856e-02	1.239
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	6.092841e-02	1.215
Signal transduction by L1	R-HSA-445144	7.729134e-02	1.112
STING mediated induction of host immune responses	R-HSA-1834941	7.031694e-02	1.153
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	8.152131e-02	1.089
Regulation of CDH1 Expression and Function	R-HSA-9764265	8.152131e-02	1.089
MECP2 regulates transcription factors	R-HSA-9022707	5.982482e-02	1.223
Adrenoceptors	R-HSA-390696	7.058282e-02	1.151
RSK activation	R-HSA-444257	7.058282e-02	1.151
Glycolysis	R-HSA-70171	7.559031e-02	1.122
Tie2 Signaling	R-HSA-210993	6.364343e-02	1.196
Maturation of nucleoprotein	R-HSA-9694631	7.031694e-02	1.153
Uptake and function of diphtheria toxin	R-HSA-5336415	5.982482e-02	1.223
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	5.982482e-02	1.223
Respiratory syncytial virus genome replication	R-HSA-9834752	8.191191e-02	1.087
Signaling by ROBO receptors	R-HSA-376176	6.020838e-02	1.220
Influenza Infection	R-HSA-168255	5.333400e-02	1.273
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.672500e-02	1.246
MITF-M-regulated melanocyte development	R-HSA-9730414	8.142065e-02	1.089
MITF-M-dependent gene expression	R-HSA-9856651	7.236728e-02	1.140
Interleukin-37 signaling	R-HSA-9008059	5.550051e-02	1.256
HSF1-dependent transactivation	R-HSA-3371571	8.608677e-02	1.065
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	8.611982e-02	1.065
Chromosome Maintenance	R-HSA-73886	8.974091e-02	1.047
Interleukin-17 signaling	R-HSA-448424	9.074803e-02	1.042
PTEN Loss of Function in Cancer	R-HSA-5674404	1.114156e-01	0.953
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	1.114156e-01	0.953
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	1.114156e-01	0.953
Defective SLC17A5 causes Salla disease (SD) and ISSD	R-HSA-5619035	1.114156e-01	0.953
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	1.114156e-01	0.953
XAV939 stabilizes AXIN	R-HSA-5545619	1.114156e-01	0.953
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	1.114156e-01	0.953
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	1.114156e-01	0.953
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	1.114156e-01	0.953
Signaling by TCF7L2 mutants	R-HSA-5339700	1.114156e-01	0.953
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	9.375212e-02	1.028
Folding of actin by CCT/TriC	R-HSA-390450	9.375212e-02	1.028
Activated NTRK3 signals through RAS	R-HSA-9034864	1.060472e-01	0.975
Activated NTRK2 signals through RAS	R-HSA-9026519	1.187446e-01	0.925
ERKs are inactivated	R-HSA-202670	1.187446e-01	0.925
Signaling by GSK3beta mutants	R-HSA-5339716	1.187446e-01	0.925
Leading Strand Synthesis	R-HSA-69109	1.317950e-01	0.880
Polymerase switching	R-HSA-69091	1.317950e-01	0.880
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.317950e-01	0.880
Scavenging by Class F Receptors	R-HSA-3000484	1.317950e-01	0.880
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.317950e-01	0.880
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.317950e-01	0.880
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.317950e-01	0.880
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.317950e-01	0.880
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	9.209950e-02	1.036
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.079769e-01	0.967
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.162866e-01	0.934
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.162866e-01	0.934
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.248273e-01	0.904
Vpr-mediated nuclear import of PICs	R-HSA-180910	9.782175e-02	1.010
Attenuation phase	R-HSA-3371568	1.166718e-01	0.933
Meiotic synapsis	R-HSA-1221632	9.569632e-02	1.019
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.369663e-01	0.863
Dual incision in TC-NER	R-HSA-6782135	1.219604e-01	0.914
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.036513e-01	0.984
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.036513e-01	0.984
Centrosome maturation	R-HSA-380287	1.127568e-01	0.948
Formation of a pool of free 40S subunits	R-HSA-72689	1.288280e-01	0.890
HIV Transcription Elongation	R-HSA-167169	1.166718e-01	0.933
RAF-independent MAPK1/3 activation	R-HSA-112409	9.991045e-02	1.000
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.079769e-01	0.967
Extension of Telomeres	R-HSA-180786	1.275796e-01	0.894
Sensing of DNA Double Strand Breaks	R-HSA-5693548	1.187446e-01	0.925
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	9.965678e-02	1.001
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.166718e-01	0.933
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.275796e-01	0.894
EGFR Transactivation by Gastrin	R-HSA-2179392	9.375212e-02	1.028
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	1.300493e-01	0.886
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.102215e-01	0.958
Peptide chain elongation	R-HSA-156902	9.205986e-02	1.036
MAPK3 (ERK1) activation	R-HSA-110056	9.375212e-02	1.028
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.110813e-01	0.954
Integration of provirus	R-HSA-162592	1.187446e-01	0.925
Regulation of PTEN mRNA translation	R-HSA-8943723	1.079769e-01	0.967
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	9.782175e-02	1.010
p75NTR recruits signalling complexes	R-HSA-209543	1.317950e-01	0.880
Polymerase switching on the C-strand of the telomere	R-HSA-174411	1.248273e-01	0.904
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.054419e-01	0.977
Negative regulation of MAPK pathway	R-HSA-5675221	1.300493e-01	0.886
MET activates RAS signaling	R-HSA-8851805	1.317950e-01	0.880
VEGFR2 mediated cell proliferation	R-HSA-5218921	1.248273e-01	0.904
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.595705e-02	1.018
Interleukin-6 family signaling	R-HSA-6783589	1.162866e-01	0.934
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	1.114156e-01	0.953
NF-kB is activated and signals survival	R-HSA-209560	1.187446e-01	0.925
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.166718e-01	0.933
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	9.991045e-02	1.000
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	1.335865e-01	0.874
Listeria monocytogenes entry into host cells	R-HSA-8876384	9.209950e-02	1.036
Breakdown of the nuclear lamina	R-HSA-352238	1.114156e-01	0.953
Signaling by PDGFR in disease	R-HSA-9671555	9.209950e-02	1.036
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.128503e-01	0.947
MyD88-independent TLR4 cascade	R-HSA-166166	1.128503e-01	0.947
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	9.485275e-02	1.023
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.369663e-01	0.863
Sema4D in semaphorin signaling	R-HSA-400685	1.248273e-01	0.904
Suppression of apoptosis	R-HSA-9635465	1.060472e-01	0.975
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.162866e-01	0.934
Cell-Cell communication	R-HSA-1500931	1.202147e-01	0.920
Selective autophagy	R-HSA-9663891	9.205986e-02	1.036
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	9.375212e-02	1.028
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	1.317950e-01	0.880
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.079769e-01	0.967
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.079769e-01	0.967
Macroautophagy	R-HSA-1632852	9.890642e-02	1.005
Calmodulin induced events	R-HSA-111933	9.188144e-02	1.037
CaM pathway	R-HSA-111997	9.188144e-02	1.037
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.050095e-01	0.979
Protein ubiquitination	R-HSA-8852135	1.127568e-01	0.948
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	1.300493e-01	0.886
Interferon Signaling	R-HSA-913531	1.237991e-01	0.907
Regulation of the apoptosome activity	R-HSA-9627069	9.375212e-02	1.028
Signaling by ALK	R-HSA-201556	1.102215e-01	0.958
Nuclear signaling by ERBB4	R-HSA-1251985	1.166718e-01	0.933
Formation of apoptosome	R-HSA-111458	9.375212e-02	1.028
RUNX2 regulates bone development	R-HSA-8941326	9.188144e-02	1.037
Neurodegenerative Diseases	R-HSA-8863678	1.162866e-01	0.934
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.162866e-01	0.934
Cytochrome c-mediated apoptotic response	R-HSA-111461	1.187446e-01	0.925
Epigenetic regulation of gene expression	R-HSA-212165	1.370116e-01	0.863
Telomere Maintenance	R-HSA-157579	1.378730e-01	0.861
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.382958e-01	0.859
PLC beta mediated events	R-HSA-112043	1.391639e-01	0.856
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.425089e-01	0.846
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.425089e-01	0.846
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.425089e-01	0.846
Processive synthesis on the C-strand of the telomere	R-HSA-174414	1.425517e-01	0.846
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.425517e-01	0.846
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.425517e-01	0.846
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.425517e-01	0.846
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	1.425517e-01	0.846
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.425517e-01	0.846
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.457281e-01	0.836
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	1.787176e-01	0.748
Axonal growth stimulation	R-HSA-209563	1.787176e-01	0.748
Defective ABCC2 causes DJS	R-HSA-5679001	1.787176e-01	0.748
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	2.104351e-01	0.677
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.104351e-01	0.677
Nucleotide catabolism defects	R-HSA-9735786	2.104351e-01	0.677
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.104351e-01	0.677
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.104351e-01	0.677
NTRK2 activates RAC1	R-HSA-9032759	2.409296e-01	0.618
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.409296e-01	0.618
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.409296e-01	0.618
Plus-strand DNA synthesis	R-HSA-164525	2.702481e-01	0.568
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.702481e-01	0.568
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	2.702481e-01	0.568
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	2.702481e-01	0.568
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	2.702481e-01	0.568
Signaling by MAPK mutants	R-HSA-9652817	2.702481e-01	0.568
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	1.451524e-01	0.838
CD28 dependent Vav1 pathway	R-HSA-389359	1.451524e-01	0.838
Adenylate cyclase activating pathway	R-HSA-170660	1.451524e-01	0.838
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.587736e-01	0.799
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.726185e-01	0.763
Adenylate cyclase inhibitory pathway	R-HSA-170670	1.726185e-01	0.763
Beta-catenin phosphorylation cascade	R-HSA-196299	1.726185e-01	0.763
SHC1 events in EGFR signaling	R-HSA-180336	1.726185e-01	0.763
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.866496e-01	0.729
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.008320e-01	0.697
PI3K events in ERBB2 signaling	R-HSA-1963642	2.151331e-01	0.667
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	2.151331e-01	0.667
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.151331e-01	0.667
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	1.517103e-01	0.819
Formation of the Early Elongation Complex	R-HSA-113418	1.517103e-01	0.819
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	2.295227e-01	0.639
DAP12 signaling	R-HSA-2424491	1.705579e-01	0.768
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.705579e-01	0.768
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.439726e-01	0.613
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.802220e-01	0.744
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.802220e-01	0.744
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.802220e-01	0.744
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.584569e-01	0.588
IPs transport between nucleus and cytosol	R-HSA-1855170	1.999700e-01	0.699
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.999700e-01	0.699
SHC-mediated cascade:FGFR3	R-HSA-5654704	2.729514e-01	0.564
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.729514e-01	0.564
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.100300e-01	0.678
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.100300e-01	0.678
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.100300e-01	0.678
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.660298e-01	0.780
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.660298e-01	0.780
SHC-mediated cascade:FGFR4	R-HSA-5654719	2.874337e-01	0.541
Dual Incision in GG-NER	R-HSA-5696400	2.201985e-01	0.657
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.451235e-01	0.838
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.304640e-01	0.637
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.476304e-01	0.831
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.722780e-01	0.565
Translation initiation complex formation	R-HSA-72649	2.296690e-01	0.639
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.828674e-01	0.548
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.828674e-01	0.548
Ribosomal scanning and start codon recognition	R-HSA-72702	2.464544e-01	0.608
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.046158e-01	0.689
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	2.107101e-01	0.676
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.356920e-01	0.628
Lagging Strand Synthesis	R-HSA-69186	2.729514e-01	0.564
Early Phase of HIV Life Cycle	R-HSA-162594	2.729514e-01	0.564
Activation of the pre-replicative complex	R-HSA-68962	1.705579e-01	0.768
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	1.866496e-01	0.729
PERK regulates gene expression	R-HSA-381042	2.304640e-01	0.637
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.828674e-01	0.548
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.512419e-01	0.600
Regulation of gap junction activity	R-HSA-191650	2.104351e-01	0.677
Formation of axial mesoderm	R-HSA-9796292	1.451524e-01	0.838
Germ layer formation at gastrulation	R-HSA-9754189	2.439726e-01	0.613
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	2.584569e-01	0.588
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.213871e-01	0.655
Signalling to RAS	R-HSA-167044	2.729514e-01	0.564
Resolution of D-Loop Structures	R-HSA-5693537	2.100300e-01	0.678
trans-Golgi Network Vesicle Budding	R-HSA-199992	2.101181e-01	0.678
TNFR1-mediated ceramide production	R-HSA-5626978	2.104351e-01	0.677
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.409296e-01	0.618
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	2.409296e-01	0.618
DCC mediated attractive signaling	R-HSA-418885	1.726185e-01	0.763
Activation of SMO	R-HSA-5635838	1.866496e-01	0.729
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.008320e-01	0.697
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.999700e-01	0.699
Fanconi Anemia Pathway	R-HSA-6783310	1.585656e-01	0.800
RAF activation	R-HSA-5673000	2.201985e-01	0.657
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	2.201985e-01	0.657
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.980983e-01	0.703
COPI-mediated anterograde transport	R-HSA-6807878	2.485118e-01	0.605
p75NTR signals via NF-kB	R-HSA-193639	1.726185e-01	0.763
Aryl hydrocarbon receptor signalling	R-HSA-8937144	2.702481e-01	0.568
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	2.151331e-01	0.667
Nuclear RNA decay	R-HSA-9930044	1.999700e-01	0.699
Transcriptional regulation by small RNAs	R-HSA-5578749	2.101181e-01	0.678
Eukaryotic Translation Termination	R-HSA-72764	2.420766e-01	0.616
Mismatch Repair	R-HSA-5358508	2.295227e-01	0.639
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	2.151331e-01	0.667
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	2.151331e-01	0.667
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.549953e-01	0.593
TCF dependent signaling in response to WNT	R-HSA-201681	1.782105e-01	0.749
Neurophilin interactions with VEGF and VEGFR	R-HSA-194306	1.457281e-01	0.836
ATP sensitive Potassium channels	R-HSA-1296025	2.104351e-01	0.677
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.409296e-01	0.618
Noncanonical activation of NOTCH3	R-HSA-9017802	2.702481e-01	0.568
CDC6 association with the ORC:origin complex	R-HSA-68689	2.702481e-01	0.568
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.151331e-01	0.667
PKA activation in glucagon signalling	R-HSA-164378	2.295227e-01	0.639
Viral Messenger RNA Synthesis	R-HSA-168325	2.894441e-01	0.538
Downstream signaling of activated FGFR3	R-HSA-5654708	1.610499e-01	0.793
Downstream signaling of activated FGFR4	R-HSA-5654716	1.705579e-01	0.768
Downstream signaling of activated FGFR2	R-HSA-5654696	2.304640e-01	0.637
Frs2-mediated activation	R-HSA-170968	1.451524e-01	0.838
Downstream signaling of activated FGFR1	R-HSA-5654687	2.304640e-01	0.637
Signaling by WNT	R-HSA-195721	1.935863e-01	0.713
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	2.828674e-01	0.548
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	2.828674e-01	0.548
Atorvastatin ADME	R-HSA-9754706	1.866496e-01	0.729
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.980983e-01	0.703
Signaling by TGFB family members	R-HSA-9006936	2.712471e-01	0.567
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.587736e-01	0.799
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.726185e-01	0.763
FGFR1 mutant receptor activation	R-HSA-1839124	1.999700e-01	0.699
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.100300e-01	0.678
NOD1/2 Signaling Pathway	R-HSA-168638	2.201985e-01	0.657
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.035321e-01	0.691
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	2.726539e-01	0.564
G-protein mediated events	R-HSA-112040	1.764751e-01	0.753
Platelet degranulation	R-HSA-114608	2.010638e-01	0.697
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	2.726539e-01	0.564
Cellular Senescence	R-HSA-2559583	2.622352e-01	0.581
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.258160e-01	0.646
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.430567e-01	0.614
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	1.787176e-01	0.748
VEGF binds to VEGFR leading to receptor dimerization	R-HSA-195399	2.702481e-01	0.568
Transport of connexons to the plasma membrane	R-HSA-190872	2.295227e-01	0.639
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	2.729514e-01	0.564
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	1.585656e-01	0.800
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.583995e-01	0.800
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	2.634970e-01	0.579
FCGR3A-mediated phagocytosis	R-HSA-9664422	2.807700e-01	0.552
Parasite infection	R-HSA-9664407	2.807700e-01	0.552
Leishmania phagocytosis	R-HSA-9664417	2.807700e-01	0.552
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.964130e-01	0.707
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	1.705579e-01	0.768
Downstream signal transduction	R-HSA-186763	1.802220e-01	0.744
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.585656e-01	0.800
Transcriptional Regulation by E2F6	R-HSA-8953750	2.722780e-01	0.565
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.610499e-01	0.793
Nuclear import of Rev protein	R-HSA-180746	2.201985e-01	0.657
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	2.380267e-01	0.623
Kinesins	R-HSA-983189	2.807513e-01	0.552
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.450868e-01	0.838
Selenocysteine synthesis	R-HSA-2408557	2.813621e-01	0.551
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.060748e-01	0.686
Aquaporin-mediated transport	R-HSA-445717	2.894441e-01	0.538
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.999700e-01	0.699
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.469164e-01	0.833
G2/M Transition	R-HSA-69275	1.899884e-01	0.721
Interferon gamma signaling	R-HSA-877300	2.661024e-01	0.575
Mitotic G2-G2/M phases	R-HSA-453274	1.980324e-01	0.703
FLT3 signaling through SRC family kinases	R-HSA-9706374	2.104351e-01	0.677
NrCAM interactions	R-HSA-447038	2.409296e-01	0.618
Reelin signalling pathway	R-HSA-8866376	2.409296e-01	0.618
VEGF ligand-receptor interactions	R-HSA-194313	2.702481e-01	0.568
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	1.866496e-01	0.729
PKA activation	R-HSA-163615	2.295227e-01	0.639
Interactions of Rev with host cellular proteins	R-HSA-177243	2.828674e-01	0.548
Adherens junctions interactions	R-HSA-418990	2.330627e-01	0.633
Heme signaling	R-HSA-9707616	1.451235e-01	0.838
GPVI-mediated activation cascade	R-HSA-114604	2.408154e-01	0.618
Cell-cell junction organization	R-HSA-421270	2.745598e-01	0.561
Signaling by MET	R-HSA-6806834	2.676301e-01	0.572
Hemostasis	R-HSA-109582	1.454422e-01	0.837
Signaling by PDGF	R-HSA-186797	1.451235e-01	0.838
Maturation of nucleoprotein	R-HSA-9683610	1.451524e-01	0.838
Cell junction organization	R-HSA-446728	2.893632e-01	0.539
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.517103e-01	0.819
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.610499e-01	0.793
Negative regulation of FGFR2 signaling	R-HSA-5654727	2.201985e-01	0.657
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	2.807513e-01	0.552
Immune System	R-HSA-168256	2.782260e-01	0.556
Viral Infection Pathways	R-HSA-9824446	2.044537e-01	0.689
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.999700e-01	0.699
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	2.874337e-01	0.541
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.617329e-01	0.582
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.722780e-01	0.565
Cell surface interactions at the vascular wall	R-HSA-202733	2.183303e-01	0.661
Estrogen-dependent gene expression	R-HSA-9018519	1.542507e-01	0.812
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.666567e-01	0.574
DAG and IP3 signaling	R-HSA-1489509	1.585656e-01	0.800
Glucose metabolism	R-HSA-70326	1.495146e-01	0.825
Signaling by Nuclear Receptors	R-HSA-9006931	2.559027e-01	0.592
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	1.451524e-01	0.838
SARS-CoV-2-host interactions	R-HSA-9705683	1.850632e-01	0.733
Signaling by NOTCH3	R-HSA-9012852	2.380267e-01	0.623
P2Y receptors	R-HSA-417957	1.587736e-01	0.799
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.874337e-01	0.541
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	2.702481e-01	0.568
PKA-mediated phosphorylation of CREB	R-HSA-111931	2.729514e-01	0.564
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	2.100300e-01	0.678
Nucleotide-like (purinergic) receptors	R-HSA-418038	2.295227e-01	0.639
Post NMDA receptor activation events	R-HSA-438064	1.809136e-01	0.743
PKR-mediated signaling	R-HSA-9833482	2.676301e-01	0.572
Detoxification of Reactive Oxygen Species	R-HSA-3299685	2.464544e-01	0.608
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.008320e-01	0.697
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.880496e-01	0.541
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	2.750627e-01	0.561
SARS-CoV-1 Infection	R-HSA-9678108	1.485964e-01	0.828
SARS-CoV Infections	R-HSA-9679506	2.661302e-01	0.575
Apoptotic factor-mediated response	R-HSA-111471	2.295227e-01	0.639
SARS-CoV-2 Infection	R-HSA-9694516	2.897949e-01	0.538
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.908493e-01	0.536
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.908493e-01	0.536
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.934913e-01	0.532
PKMTs methylate histone lysines	R-HSA-3214841	2.934913e-01	0.532
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.934913e-01	0.532
Transcriptional Regulation by VENTX	R-HSA-8853884	2.934913e-01	0.532
Viral mRNA Translation	R-HSA-192823	2.947704e-01	0.531
MHC class II antigen presentation	R-HSA-2132295	2.969762e-01	0.527
NCAM signaling for neurite out-growth	R-HSA-375165	2.981733e-01	0.526
tRNA processing in the nucleus	R-HSA-6784531	2.981733e-01	0.526
VLDL assembly	R-HSA-8866423	2.984359e-01	0.525
Chylomicron clearance	R-HSA-8964026	2.984359e-01	0.525
Autointegration results in viral DNA circles	R-HSA-177539	2.984359e-01	0.525
Uncoating of the HIV Virion	R-HSA-162585	2.984359e-01	0.525
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	2.984359e-01	0.525
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.984359e-01	0.525
Neurofascin interactions	R-HSA-447043	2.984359e-01	0.525
Lactose synthesis	R-HSA-5653890	2.984359e-01	0.525
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.984359e-01	0.525
Lipid particle organization	R-HSA-8964572	2.984359e-01	0.525
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.015221e-01	0.521
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.018832e-01	0.520
Notch-HLH transcription pathway	R-HSA-350054	3.018832e-01	0.520
mTORC1-mediated signalling	R-HSA-166208	3.018832e-01	0.520
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.018832e-01	0.520
Clathrin-mediated endocytosis	R-HSA-8856828	3.033533e-01	0.518
Signaling by FGFR1 in disease	R-HSA-5655302	3.041404e-01	0.517
Intra-Golgi traffic	R-HSA-6811438	3.041404e-01	0.517
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	3.092780e-01	0.510
GABA B receptor activation	R-HSA-977444	3.148056e-01	0.502
Activation of GABAB receptors	R-HSA-991365	3.148056e-01	0.502
Insulin receptor signalling cascade	R-HSA-74751	3.157201e-01	0.501
IGF1R signaling cascade	R-HSA-2428924	3.157201e-01	0.501
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	3.157201e-01	0.501
Interleukin receptor SHC signaling	R-HSA-912526	3.162808e-01	0.500
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	3.162808e-01	0.500
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	3.162808e-01	0.500
Growth hormone receptor signaling	R-HSA-982772	3.162808e-01	0.500
Toll-like Receptor Cascades	R-HSA-168898	3.165211e-01	0.500
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	3.245273e-01	0.489
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.254783e-01	0.487
Regulation of PTEN localization	R-HSA-8948747	3.255365e-01	0.487
VLDL clearance	R-HSA-8964046	3.255365e-01	0.487
Recycling of eIF2:GDP	R-HSA-72731	3.255365e-01	0.487
Cohesin Loading onto Chromatin	R-HSA-2470946	3.255365e-01	0.487
Disinhibition of SNARE formation	R-HSA-114516	3.255365e-01	0.487
PTK6 Expression	R-HSA-8849473	3.255365e-01	0.487
LDL remodeling	R-HSA-8964041	3.255365e-01	0.487
MET activates PI3K/AKT signaling	R-HSA-8851907	3.255365e-01	0.487
Ca2+ activated K+ channels	R-HSA-1296052	3.255365e-01	0.487
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	3.255365e-01	0.487
Netrin mediated repulsion signals	R-HSA-418886	3.255365e-01	0.487
Cation-coupled Chloride cotransporters	R-HSA-426117	3.255365e-01	0.487
CHL1 interactions	R-HSA-447041	3.255365e-01	0.487
ER to Golgi Anterograde Transport	R-HSA-199977	3.263204e-01	0.486
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	3.287885e-01	0.483
Synthesis of DNA	R-HSA-69239	3.287885e-01	0.483
Gene Silencing by RNA	R-HSA-211000	3.287885e-01	0.483
G alpha (q) signalling events	R-HSA-416476	3.305054e-01	0.481
SHC-mediated cascade:FGFR1	R-HSA-5654688	3.306091e-01	0.481
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	3.306091e-01	0.481
Plasma lipoprotein assembly	R-HSA-8963898	3.306091e-01	0.481
S Phase	R-HSA-69242	3.321113e-01	0.479
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.321113e-01	0.479
DAP12 interactions	R-HSA-2172127	3.361499e-01	0.473
Netrin-1 signaling	R-HSA-373752	3.361499e-01	0.473
SWI/SNF chromatin remodelers	R-HSA-9932451	3.448520e-01	0.462
ATP-dependent chromatin remodelers	R-HSA-9932444	3.448520e-01	0.462
Hyaluronan degradation	R-HSA-2160916	3.448520e-01	0.462
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	3.448520e-01	0.462
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	3.448520e-01	0.462
Glycogen breakdown (glycogenolysis)	R-HSA-70221	3.448520e-01	0.462
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.468126e-01	0.460
TCR signaling	R-HSA-202403	3.494434e-01	0.457
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.510244e-01	0.455
Downstream TCR signaling	R-HSA-202424	3.511398e-01	0.455
Reverse Transcription of HIV RNA	R-HSA-162589	3.515919e-01	0.454
Minus-strand DNA synthesis	R-HSA-164516	3.515919e-01	0.454
EGFR interacts with phospholipase C-gamma	R-HSA-212718	3.515919e-01	0.454
Activated NTRK2 signals through PI3K	R-HSA-9028335	3.515919e-01	0.454
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.515919e-01	0.454
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	3.515919e-01	0.454
FGFR1b ligand binding and activation	R-HSA-190370	3.515919e-01	0.454
ROBO receptors bind AKAP5	R-HSA-9010642	3.515919e-01	0.454
Axonal growth inhibition (RHOA activation)	R-HSA-193634	3.515919e-01	0.454
TGFBR3 PTM regulation	R-HSA-9839383	3.515919e-01	0.454
phospho-PLA2 pathway	R-HSA-111995	3.515919e-01	0.454
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	3.515919e-01	0.454
Downregulation of ERBB4 signaling	R-HSA-1253288	3.515919e-01	0.454
Reproduction	R-HSA-1474165	3.531475e-01	0.452
Interleukin-1 family signaling	R-HSA-446652	3.554281e-01	0.449
Signaling by TGFBR3	R-HSA-9839373	3.574584e-01	0.447
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.574584e-01	0.447
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.589947e-01	0.445
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.589947e-01	0.445
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	3.589947e-01	0.445
Urea cycle	R-HSA-70635	3.589947e-01	0.445
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.626294e-01	0.441
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.632756e-01	0.440
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.632756e-01	0.440
Organelle biogenesis and maintenance	R-HSA-1852241	3.641252e-01	0.439
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.671585e-01	0.435
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	3.680800e-01	0.434
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	3.687045e-01	0.433
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.687045e-01	0.433
SHC-mediated cascade:FGFR2	R-HSA-5654699	3.730238e-01	0.428
RNA Polymerase I Transcription Termination	R-HSA-73863	3.730238e-01	0.428
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.730238e-01	0.428
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.730238e-01	0.428
ARMS-mediated activation	R-HSA-170984	3.766422e-01	0.424
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	3.766422e-01	0.424
p75NTR regulates axonogenesis	R-HSA-193697	3.766422e-01	0.424
Calcineurin activates NFAT	R-HSA-2025928	3.766422e-01	0.424
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	3.766422e-01	0.424
Regulation of NPAS4 gene transcription	R-HSA-9768777	3.766422e-01	0.424
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	3.766422e-01	0.424
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.766422e-01	0.424
Cellular response to mitochondrial stress	R-HSA-9840373	3.766422e-01	0.424
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	3.766422e-01	0.424
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	3.766422e-01	0.424
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.766422e-01	0.424
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.766422e-01	0.424
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.766422e-01	0.424
NoRC negatively regulates rRNA expression	R-HSA-427413	3.775355e-01	0.423
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	3.775355e-01	0.423
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	3.782027e-01	0.422
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.786703e-01	0.422
Gluconeogenesis	R-HSA-70263	3.786703e-01	0.422
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.863546e-01	0.413
Telomere Extension By Telomerase	R-HSA-171319	3.869268e-01	0.412
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.869268e-01	0.412
DNA Damage Bypass	R-HSA-73893	3.892224e-01	0.410
Gap junction trafficking and regulation	R-HSA-157858	3.892224e-01	0.410
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.897052e-01	0.409
TP53 Regulates Metabolic Genes	R-HSA-5628897	3.910069e-01	0.408
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.951578e-01	0.403
Ca2+ pathway	R-HSA-4086398	3.951578e-01	0.403
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.951578e-01	0.403
Beta-catenin independent WNT signaling	R-HSA-3858494	3.975446e-01	0.401
mRNA Capping	R-HSA-72086	4.006927e-01	0.397
Termination of translesion DNA synthesis	R-HSA-5656169	4.006927e-01	0.397
Signaling by Erythropoietin	R-HSA-9006335	4.006927e-01	0.397
Signaling by CSF3 (G-CSF)	R-HSA-9674555	4.006927e-01	0.397
Binding and entry of HIV virion	R-HSA-173107	4.007263e-01	0.397
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.007263e-01	0.397
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	4.007263e-01	0.397
Interleukin-27 signaling	R-HSA-9020956	4.007263e-01	0.397
PI3K/AKT activation	R-HSA-198203	4.007263e-01	0.397
2-LTR circle formation	R-HSA-164843	4.007263e-01	0.397
Arachidonate production from DAG	R-HSA-426048	4.007263e-01	0.397
Pexophagy	R-HSA-9664873	4.007263e-01	0.397
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	4.007263e-01	0.397
Receptor Mediated Mitophagy	R-HSA-8934903	4.007263e-01	0.397
Signaling by FGFR in disease	R-HSA-1226099	4.039408e-01	0.394
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	4.051060e-01	0.392
Ribosome-associated quality control	R-HSA-9948299	4.102493e-01	0.387
Mitochondrial biogenesis	R-HSA-1592230	4.117952e-01	0.385
CLEC7A (Dectin-1) signaling	R-HSA-5607764	4.127895e-01	0.384
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.143114e-01	0.383
Transcriptional regulation by RUNX3	R-HSA-8878159	4.204581e-01	0.376
mRNA 3'-end processing	R-HSA-72187	4.205870e-01	0.376
RNA Polymerase I Promoter Escape	R-HSA-73772	4.205870e-01	0.376
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.205870e-01	0.376
Transcriptional Regulation by NPAS4	R-HSA-9634815	4.205870e-01	0.376
RNA Polymerase I Promoter Clearance	R-HSA-73854	4.214311e-01	0.375
Chylomicron assembly	R-HSA-8963888	4.238812e-01	0.373
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.238812e-01	0.373
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.238812e-01	0.373
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.238812e-01	0.373
vRNP Assembly	R-HSA-192905	4.238812e-01	0.373
Signaling by APC mutants	R-HSA-4839744	4.238812e-01	0.373
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.238812e-01	0.373
Interleukin-2 signaling	R-HSA-9020558	4.238812e-01	0.373
EGFR downregulation	R-HSA-182971	4.277736e-01	0.369
Budding and maturation of HIV virion	R-HSA-162588	4.277736e-01	0.369
Trafficking of AMPA receptors	R-HSA-399719	4.277736e-01	0.369
Cargo concentration in the ER	R-HSA-5694530	4.277736e-01	0.369
Post-translational protein phosphorylation	R-HSA-8957275	4.281093e-01	0.368
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	4.292736e-01	0.367
Translation of Structural Proteins	R-HSA-9694635	4.301309e-01	0.366
p75 NTR receptor-mediated signalling	R-HSA-193704	4.357403e-01	0.361
RNA Polymerase I Transcription	R-HSA-73864	4.387956e-01	0.358
G alpha (12/13) signalling events	R-HSA-416482	4.387956e-01	0.358
PCP/CE pathway	R-HSA-4086400	4.387956e-01	0.358
Nuclear events mediated by NFE2L2	R-HSA-9759194	4.393925e-01	0.357
Cilium Assembly	R-HSA-5617833	4.395419e-01	0.357
Diseases of mitotic cell cycle	R-HSA-9675126	4.410711e-01	0.355
Inwardly rectifying K+ channels	R-HSA-1296065	4.410711e-01	0.355
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	4.411956e-01	0.355
Scavenging by Class H Receptors	R-HSA-3000497	4.461428e-01	0.351
PI3K events in ERBB4 signaling	R-HSA-1250342	4.461428e-01	0.351
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.461428e-01	0.351
Signaling by AXIN mutants	R-HSA-4839735	4.461428e-01	0.351
Signaling by AMER1 mutants	R-HSA-4839748	4.461428e-01	0.351
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	4.461428e-01	0.351
Activation of RAC1	R-HSA-428540	4.461428e-01	0.351
Sensory processing of sound	R-HSA-9659379	4.474219e-01	0.349
HDACs deacetylate histones	R-HSA-3214815	4.513937e-01	0.345
G alpha (z) signalling events	R-HSA-418597	4.513937e-01	0.345
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	4.541966e-01	0.343
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	4.541966e-01	0.343
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	4.541966e-01	0.343
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	4.541966e-01	0.343
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	4.541966e-01	0.343
Regulation of necroptotic cell death	R-HSA-5675482	4.541966e-01	0.343
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.560064e-01	0.341
Regulation of endogenous retroelements	R-HSA-9842860	4.584881e-01	0.339
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	4.615147e-01	0.336
Striated Muscle Contraction	R-HSA-390522	4.671436e-01	0.331
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	4.671436e-01	0.331
Glucagon signaling in metabolic regulation	R-HSA-163359	4.671436e-01	0.331
Effects of PIP2 hydrolysis	R-HSA-114508	4.671436e-01	0.331
Miscellaneous transport and binding events	R-HSA-5223345	4.671436e-01	0.331
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	4.675455e-01	0.330
IRAK1 recruits IKK complex	R-HSA-937039	4.675455e-01	0.330
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.675455e-01	0.330
Repression of WNT target genes	R-HSA-4641265	4.675455e-01	0.330
GRB2 events in EGFR signaling	R-HSA-179812	4.675455e-01	0.330
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.675455e-01	0.330
Serotonin clearance from the synaptic cleft	R-HSA-380615	4.675455e-01	0.330
Interleukin-35 Signalling	R-HSA-8984722	4.675455e-01	0.330
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.675455e-01	0.330
Interleukin-15 signaling	R-HSA-8983432	4.675455e-01	0.330
Trafficking and processing of endosomal TLR	R-HSA-1679131	4.675455e-01	0.330
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	4.675455e-01	0.330
OAS antiviral response	R-HSA-8983711	4.675455e-01	0.330
Innate Immune System	R-HSA-168249	4.721847e-01	0.326
C-type lectin receptors (CLRs)	R-HSA-5621481	4.729348e-01	0.325
Opioid Signalling	R-HSA-111885	4.735088e-01	0.325
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	4.799062e-01	0.319
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	4.799062e-01	0.319
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	4.799062e-01	0.319
Hyaluronan metabolism	R-HSA-2142845	4.799062e-01	0.319
Signal amplification	R-HSA-392518	4.799062e-01	0.319
Gap junction assembly	R-HSA-190861	4.799062e-01	0.319
Mitophagy	R-HSA-5205647	4.799062e-01	0.319
NPAS4 regulates expression of target genes	R-HSA-9768919	4.799062e-01	0.319
Chylomicron remodeling	R-HSA-8963901	4.881224e-01	0.311
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.881224e-01	0.311
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.881224e-01	0.311
Diseases of nucleotide metabolism	R-HSA-9735804	4.881224e-01	0.311
FGFR1c ligand binding and activation	R-HSA-190373	4.881224e-01	0.311
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	4.881224e-01	0.311
Platelet Adhesion to exposed collagen	R-HSA-75892	4.881224e-01	0.311
Potential therapeutics for SARS	R-HSA-9679191	4.919134e-01	0.308
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	4.960478e-01	0.304
GABA receptor activation	R-HSA-977443	5.011431e-01	0.300
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	5.011431e-01	0.300
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	5.011431e-01	0.300
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	5.011431e-01	0.300
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	5.011431e-01	0.300
Signaling by NOTCH1 in Cancer	R-HSA-2644603	5.011431e-01	0.300
Vif-mediated degradation of APOBEC3G	R-HSA-180585	5.048586e-01	0.297
Lysosome Vesicle Biogenesis	R-HSA-432720	5.048586e-01	0.297
FLT3 signaling in disease	R-HSA-9682385	5.048586e-01	0.297
G1/S-Specific Transcription	R-HSA-69205	5.048586e-01	0.297
Regulation of TP53 Degradation	R-HSA-6804757	5.048586e-01	0.297
CRMPs in Sema3A signaling	R-HSA-399956	5.079054e-01	0.294
Removal of the Flap Intermediate	R-HSA-69166	5.079054e-01	0.294
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.079054e-01	0.294
cGMP effects	R-HSA-418457	5.079054e-01	0.294
Signaling by FGFR4 in disease	R-HSA-5655291	5.079054e-01	0.294
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.079054e-01	0.294
HDL assembly	R-HSA-8963896	5.079054e-01	0.294
Signal regulatory protein family interactions	R-HSA-391160	5.079054e-01	0.294
Zinc transporters	R-HSA-435354	5.079054e-01	0.294
RNA Polymerase II Transcription Termination	R-HSA-73856	5.108174e-01	0.292
Death Receptor Signaling	R-HSA-73887	5.164162e-01	0.287
TRAF6 mediated IRF7 activation	R-HSA-933541	5.170403e-01	0.286
Ovarian tumor domain proteases	R-HSA-5689896	5.170403e-01	0.286
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.203919e-01	0.284
Chaperonin-mediated protein folding	R-HSA-390466	5.228257e-01	0.282
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	5.267634e-01	0.278
Golgi-to-ER retrograde transport	R-HSA-8856688	5.267762e-01	0.278
RNA Polymerase III Chain Elongation	R-HSA-73780	5.269249e-01	0.278
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.269249e-01	0.278
Processive synthesis on the lagging strand	R-HSA-69183	5.269249e-01	0.278
Translesion synthesis by REV1	R-HSA-110312	5.269249e-01	0.278
Erythropoietin activates RAS	R-HSA-9027284	5.269249e-01	0.278
Telomere C-strand synthesis initiation	R-HSA-174430	5.269249e-01	0.278
p38MAPK events	R-HSA-171007	5.269249e-01	0.278
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	5.269249e-01	0.278
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.269249e-01	0.278
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.269249e-01	0.278
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.269249e-01	0.278
Protein methylation	R-HSA-8876725	5.269249e-01	0.278
Lysosphingolipid and LPA receptors	R-HSA-419408	5.269249e-01	0.278
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.269249e-01	0.278
Cell-extracellular matrix interactions	R-HSA-446353	5.269249e-01	0.278
RIPK1-mediated regulated necrosis	R-HSA-5213460	5.290212e-01	0.277
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.298637e-01	0.276
Signaling by PTK6	R-HSA-8848021	5.298637e-01	0.276
Disease	R-HSA-1643685	5.314723e-01	0.275
Inositol phosphate metabolism	R-HSA-1483249	5.391881e-01	0.268
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	5.404849e-01	0.267
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	5.407985e-01	0.267
Regulation of TP53 Expression and Degradation	R-HSA-6806003	5.407985e-01	0.267
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	5.407985e-01	0.267
Translesion synthesis by POLI	R-HSA-5656121	5.452104e-01	0.263
Phosphorylation of the APC/C	R-HSA-176412	5.452104e-01	0.263
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.452104e-01	0.263
Fructose catabolism	R-HSA-70350	5.452104e-01	0.263
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.452104e-01	0.263
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.452104e-01	0.263
Regulation of NF-kappa B signaling	R-HSA-9758274	5.452104e-01	0.263
Base Excision Repair	R-HSA-73884	5.468639e-01	0.262
Interleukin-2 family signaling	R-HSA-451927	5.523701e-01	0.258
Glycogen metabolism	R-HSA-8982491	5.523701e-01	0.258
Membrane Trafficking	R-HSA-199991	5.545697e-01	0.256
Transcriptional Regulation by MECP2	R-HSA-8986944	5.547358e-01	0.256
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	5.602345e-01	0.252
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.627902e-01	0.250
Translesion synthesis by POLK	R-HSA-5655862	5.627902e-01	0.250
Scavenging by Class B Receptors	R-HSA-3000471	5.627902e-01	0.250
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.627902e-01	0.250
TRAF3-dependent IRF activation pathway	R-HSA-918233	5.627902e-01	0.250
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	5.627902e-01	0.250
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.627902e-01	0.250
Acetylcholine regulates insulin secretion	R-HSA-399997	5.627902e-01	0.250
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	5.627902e-01	0.250
Passive transport by Aquaporins	R-HSA-432047	5.627902e-01	0.250
Fibronectin matrix formation	R-HSA-1566977	5.627902e-01	0.250
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	5.627902e-01	0.250
Galactose catabolism	R-HSA-70370	5.627902e-01	0.250
Biosynthesis of maresin-like SPMs	R-HSA-9027307	5.627902e-01	0.250
Muscle contraction	R-HSA-397014	5.629610e-01	0.250
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.637344e-01	0.249
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.637344e-01	0.249
FLT3 Signaling	R-HSA-9607240	5.637344e-01	0.249
Protein folding	R-HSA-391251	5.702578e-01	0.244
Signaling by Insulin receptor	R-HSA-74752	5.702578e-01	0.244
Late SARS-CoV-2 Infection Events	R-HSA-9772573	5.702578e-01	0.244
Scavenging by Class A Receptors	R-HSA-3000480	5.748900e-01	0.240
SLC-mediated transport of neurotransmitters	R-HSA-442660	5.748900e-01	0.240
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	5.748900e-01	0.240
Translation of Structural Proteins	R-HSA-9683701	5.748900e-01	0.240
Selenoamino acid metabolism	R-HSA-2408522	5.756271e-01	0.240
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	5.796915e-01	0.237
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	5.796915e-01	0.237
Regulation of NPAS4 gene expression	R-HSA-9768759	5.796915e-01	0.237
Regulation of FZD by ubiquitination	R-HSA-4641263	5.796915e-01	0.237
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	5.796915e-01	0.237
Phospholipid metabolism	R-HSA-1483257	5.850558e-01	0.233
MTOR signalling	R-HSA-165159	5.858362e-01	0.232
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.858362e-01	0.232
Incretin synthesis, secretion, and inactivation	R-HSA-400508	5.858362e-01	0.232
Adaptive Immune System	R-HSA-1280218	5.866943e-01	0.232
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	5.929635e-01	0.227
Degradation of beta-catenin by the destruction complex	R-HSA-195253	5.930917e-01	0.227
RNA Polymerase III Transcription Termination	R-HSA-73980	5.959404e-01	0.225
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	5.959404e-01	0.225
Platelet sensitization by LDL	R-HSA-432142	5.959404e-01	0.225
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	5.959404e-01	0.225
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	5.959404e-01	0.225
FGFR1 ligand binding and activation	R-HSA-190242	5.959404e-01	0.225
Regulation of TP53 Activity through Methylation	R-HSA-6804760	5.959404e-01	0.225
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	5.959404e-01	0.225
Vitamin D (calciferol) metabolism	R-HSA-196791	5.959404e-01	0.225
Response of Mtb to phagocytosis	R-HSA-9637690	5.965724e-01	0.224
Transcriptional regulation by RUNX2	R-HSA-8878166	6.008210e-01	0.221
RMTs methylate histone arginines	R-HSA-3214858	6.070985e-01	0.217
Gap junction trafficking	R-HSA-190828	6.070985e-01	0.217
Amine ligand-binding receptors	R-HSA-375280	6.070985e-01	0.217
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	6.077002e-01	0.216
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	6.101136e-01	0.215
PI-3K cascade:FGFR3	R-HSA-5654710	6.115621e-01	0.214
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.115621e-01	0.214
Translesion Synthesis by POLH	R-HSA-110320	6.115621e-01	0.214
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.115621e-01	0.214
Specification of the neural plate border	R-HSA-9834899	6.115621e-01	0.214
IKK complex recruitment mediated by RIP1	R-HSA-937041	6.115621e-01	0.214
E2F mediated regulation of DNA replication	R-HSA-113510	6.115621e-01	0.214
The NLRP3 inflammasome	R-HSA-844456	6.115621e-01	0.214
O2/CO2 exchange in erythrocytes	R-HSA-1480926	6.115621e-01	0.214
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	6.115621e-01	0.214
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.115621e-01	0.214
Crosslinking of collagen fibrils	R-HSA-2243919	6.115621e-01	0.214
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	6.174147e-01	0.209
Nucleosome assembly	R-HSA-774815	6.174147e-01	0.209
Asymmetric localization of PCP proteins	R-HSA-4608870	6.174147e-01	0.209
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	6.174147e-01	0.209
Switching of origins to a post-replicative state	R-HSA-69052	6.184441e-01	0.209
Mitotic G1 phase and G1/S transition	R-HSA-453279	6.257632e-01	0.204
PI-3K cascade:FGFR4	R-HSA-5654720	6.265807e-01	0.203
Post-chaperonin tubulin folding pathway	R-HSA-389977	6.265807e-01	0.203
Synthesis of Ketone Bodies	R-HSA-77111	6.265807e-01	0.203
Protein hydroxylation	R-HSA-9629569	6.265807e-01	0.203
Negative regulation of MET activity	R-HSA-6807004	6.265807e-01	0.203
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	6.265807e-01	0.203
Glycogen synthesis	R-HSA-3322077	6.265807e-01	0.203
mRNA Splicing - Minor Pathway	R-HSA-72165	6.275215e-01	0.202
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	6.275215e-01	0.202
FOXO-mediated transcription	R-HSA-9614085	6.291831e-01	0.201
Hedgehog 'off' state	R-HSA-5610787	6.361747e-01	0.196
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	6.374197e-01	0.196
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	6.374197e-01	0.196
Leishmania infection	R-HSA-9658195	6.388191e-01	0.195
Parasitic Infection Pathways	R-HSA-9824443	6.388191e-01	0.195
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	6.410196e-01	0.193
Vitamin C (ascorbate) metabolism	R-HSA-196836	6.410196e-01	0.193
Basigin interactions	R-HSA-210991	6.410196e-01	0.193
Transport to the Golgi and subsequent modification	R-HSA-948021	6.414246e-01	0.193
UCH proteinases	R-HSA-5689603	6.427040e-01	0.192
Signaling by NOTCH1	R-HSA-1980143	6.427040e-01	0.192
Interleukin-1 signaling	R-HSA-9020702	6.430803e-01	0.192
G1/S Transition	R-HSA-69206	6.453770e-01	0.190
Regulation of T cell activation by CD28 family	R-HSA-388841	6.466278e-01	0.189
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	6.514813e-01	0.186
KEAP1-NFE2L2 pathway	R-HSA-9755511	6.541366e-01	0.184
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.549010e-01	0.184
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	6.549010e-01	0.184
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	6.549010e-01	0.184
Ribavirin ADME	R-HSA-9755088	6.549010e-01	0.184
Assembly Of The HIV Virion	R-HSA-175474	6.549010e-01	0.184
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	6.565944e-01	0.183
Integrin cell surface interactions	R-HSA-216083	6.582626e-01	0.182
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	6.596500e-01	0.181
DNA Replication	R-HSA-69306	6.651084e-01	0.177
Signaling by FGFR2 in disease	R-HSA-5655253	6.658737e-01	0.177
PI-3K cascade:FGFR1	R-HSA-5654689	6.682464e-01	0.175
FGFR2 alternative splicing	R-HSA-6803529	6.682464e-01	0.175
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.682464e-01	0.175
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.682464e-01	0.175
LDL clearance	R-HSA-8964038	6.682464e-01	0.175
Cellular hexose transport	R-HSA-189200	6.682464e-01	0.175
Fructose metabolism	R-HSA-5652084	6.682464e-01	0.175
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	6.682464e-01	0.175
Meiotic recombination	R-HSA-912446	6.749497e-01	0.171
The phototransduction cascade	R-HSA-2514856	6.749497e-01	0.171
PPARA activates gene expression	R-HSA-1989781	6.758591e-01	0.170
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	6.810766e-01	0.167
Ketone body metabolism	R-HSA-74182	6.810766e-01	0.167
Biosynthesis of maresins	R-HSA-9018682	6.810766e-01	0.167
Syndecan interactions	R-HSA-3000170	6.810766e-01	0.167
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	6.810766e-01	0.167
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	6.838244e-01	0.165
Orc1 removal from chromatin	R-HSA-68949	6.838244e-01	0.165
Neurexins and neuroligins	R-HSA-6794361	6.838244e-01	0.165
Uptake and actions of bacterial toxins	R-HSA-5339562	6.838244e-01	0.165
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	6.863860e-01	0.163
Adipogenesis	R-HSA-9843745	6.866854e-01	0.163
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.878976e-01	0.162
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	6.924996e-01	0.160
Regulation of PTEN stability and activity	R-HSA-8948751	6.924996e-01	0.160
Complex III assembly	R-HSA-9865881	6.934112e-01	0.159
TRAF6 mediated NF-kB activation	R-HSA-933542	6.934112e-01	0.159
Deadenylation of mRNA	R-HSA-429947	6.934112e-01	0.159
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	6.934112e-01	0.159
Cellular response to chemical stress	R-HSA-9711123	6.972667e-01	0.157
Transmission across Chemical Synapses	R-HSA-112315	6.984755e-01	0.156
DNA Replication Pre-Initiation	R-HSA-69002	7.012885e-01	0.154
PI-3K cascade:FGFR2	R-HSA-5654695	7.052696e-01	0.152
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.052696e-01	0.152
Activation of G protein gated Potassium channels	R-HSA-1296041	7.052696e-01	0.152
G protein gated Potassium channels	R-HSA-1296059	7.052696e-01	0.152
Tight junction interactions	R-HSA-420029	7.052696e-01	0.152
TGFBR3 expression	R-HSA-9839394	7.052696e-01	0.152
Long-term potentiation	R-HSA-9620244	7.052696e-01	0.152
Acyl chain remodelling of PS	R-HSA-1482801	7.052696e-01	0.152
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.052696e-01	0.152
Formation of the nephric duct	R-HSA-9830364	7.052696e-01	0.152
MAPK6/MAPK4 signaling	R-HSA-5687128	7.088316e-01	0.149
Protein-protein interactions at synapses	R-HSA-6794362	7.088316e-01	0.149
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.092605e-01	0.149
MET activates PTK2 signaling	R-HSA-8874081	7.166700e-01	0.145
Metalloprotease DUBs	R-HSA-5689901	7.166700e-01	0.145
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.166700e-01	0.145
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	7.166700e-01	0.145
TRP channels	R-HSA-3295583	7.166700e-01	0.145
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.166700e-01	0.145
Sphingolipid catabolism	R-HSA-9845614	7.166700e-01	0.145
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.166700e-01	0.145
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.173508e-01	0.144
Ion homeostasis	R-HSA-5578775	7.173508e-01	0.144
TNF signaling	R-HSA-75893	7.173508e-01	0.144
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.173508e-01	0.144
FCERI mediated MAPK activation	R-HSA-2871796	7.190976e-01	0.143
Integration of energy metabolism	R-HSA-163685	7.194055e-01	0.143
Post-translational protein modification	R-HSA-597592	7.232016e-01	0.141
Developmental Biology	R-HSA-1266738	7.238961e-01	0.140
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	7.244269e-01	0.140
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	7.246151e-01	0.140
Interaction between L1 and Ankyrins	R-HSA-445095	7.276301e-01	0.138
Packaging Of Telomere Ends	R-HSA-171306	7.276301e-01	0.138
RNA Polymerase I Promoter Opening	R-HSA-73728	7.276301e-01	0.138
Cristae formation	R-HSA-8949613	7.276301e-01	0.138
Signaling by FGFR3 in disease	R-HSA-5655332	7.276301e-01	0.138
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	7.276301e-01	0.138
Signaling by Hedgehog	R-HSA-5358351	7.297550e-01	0.137
Infectious disease	R-HSA-5663205	7.329041e-01	0.135
Diseases of programmed cell death	R-HSA-9645723	7.350440e-01	0.134
SLC transporter disorders	R-HSA-5619102	7.356015e-01	0.133
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	7.381668e-01	0.132
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	7.381668e-01	0.132
Inflammasomes	R-HSA-622312	7.381668e-01	0.132
Pyrimidine salvage	R-HSA-73614	7.381668e-01	0.132
Prednisone ADME	R-HSA-9757110	7.381668e-01	0.132
Amino acid transport across the plasma membrane	R-HSA-352230	7.404917e-01	0.130
HCMV Early Events	R-HSA-9609690	7.418437e-01	0.130
Interferon alpha/beta signaling	R-HSA-909733	7.470156e-01	0.127
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	7.478376e-01	0.126
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.478376e-01	0.126
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	7.482966e-01	0.126
Nucleotide salvage	R-HSA-8956321	7.550041e-01	0.122
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.580350e-01	0.120
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	7.580350e-01	0.120
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	7.580350e-01	0.120
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	7.580350e-01	0.120
Neurotransmitter clearance	R-HSA-112311	7.580350e-01	0.120
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	7.580350e-01	0.120
G alpha (s) signalling events	R-HSA-418555	7.580541e-01	0.120
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.619943e-01	0.118
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	7.666343e-01	0.115
Leishmania parasite growth and survival	R-HSA-9664433	7.666343e-01	0.115
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	7.673973e-01	0.115
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.673973e-01	0.115
Evasion by RSV of host interferon responses	R-HSA-9833109	7.673973e-01	0.115
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	7.673973e-01	0.115
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	7.673973e-01	0.115
Assembly of the pre-replicative complex	R-HSA-68867	7.708228e-01	0.113
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	7.708228e-01	0.113
FCGR activation	R-HSA-2029481	7.708228e-01	0.113
Ion transport by P-type ATPases	R-HSA-936837	7.754571e-01	0.110
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	7.763978e-01	0.110
G0 and Early G1	R-HSA-1538133	7.763978e-01	0.110
Developmental Cell Lineages	R-HSA-9734767	7.827688e-01	0.106
Assembly of the ORC complex at the origin of replication	R-HSA-68616	7.850506e-01	0.105
G-protein beta:gamma signalling	R-HSA-397795	7.850506e-01	0.105
Recycling of bile acids and salts	R-HSA-159418	7.850506e-01	0.105
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	7.850506e-01	0.105
Cardiogenesis	R-HSA-9733709	7.850506e-01	0.105
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	7.850506e-01	0.105
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	7.850506e-01	0.105
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	7.882497e-01	0.103
Formation of the cornified envelope	R-HSA-6809371	7.918458e-01	0.101
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.924117e-01	0.101
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	7.924117e-01	0.101
Potassium Channels	R-HSA-1296071	7.924117e-01	0.101
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.933691e-01	0.101
Heme degradation	R-HSA-189483	7.933691e-01	0.101
SLC-mediated transport of amino acids	R-HSA-9958863	7.944022e-01	0.100
Regulated Necrosis	R-HSA-5218859	8.003963e-01	0.097
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	8.008937e-01	0.096
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	8.008937e-01	0.096
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	8.008937e-01	0.096
eNOS activation	R-HSA-203615	8.013661e-01	0.096
Signaling by NOTCH2	R-HSA-1980145	8.013661e-01	0.096
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.013661e-01	0.096
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.013661e-01	0.096
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	8.013661e-01	0.096
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.039513e-01	0.095
Neuronal System	R-HSA-112316	8.052398e-01	0.094
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.062348e-01	0.094
Regulation of Apoptosis	R-HSA-169911	8.090541e-01	0.092
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.090541e-01	0.092
COPII-mediated vesicle transport	R-HSA-204005	8.119210e-01	0.090
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.119210e-01	0.090
ABC-family proteins mediated transport	R-HSA-382556	8.122814e-01	0.090
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.164450e-01	0.088
RNA Polymerase III Transcription	R-HSA-74158	8.164450e-01	0.088
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.164450e-01	0.088
FGFR2 mutant receptor activation	R-HSA-1839126	8.164450e-01	0.088
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	8.174579e-01	0.088
Regulation of mitotic cell cycle	R-HSA-453276	8.174579e-01	0.088
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	8.174579e-01	0.088
Hedgehog 'on' state	R-HSA-5632684	8.174579e-01	0.088
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.174579e-01	0.088
Vesicle-mediated transport	R-HSA-5653656	8.213080e-01	0.085
Oxidative Stress Induced Senescence	R-HSA-2559580	8.215985e-01	0.085
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.228484e-01	0.085
Degradation of AXIN	R-HSA-4641257	8.235502e-01	0.084
Degradation of DVL	R-HSA-4641258	8.235502e-01	0.084
Cleavage of the damaged purine	R-HSA-110331	8.235502e-01	0.084
Beta-oxidation of very long chain fatty acids	R-HSA-390247	8.235502e-01	0.084
Metabolism of folate and pterines	R-HSA-196757	8.235502e-01	0.084
Disorders of transmembrane transporters	R-HSA-5619115	8.246698e-01	0.084
Aspirin ADME	R-HSA-9749641	8.280956e-01	0.082
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.303809e-01	0.081
MET promotes cell motility	R-HSA-8875878	8.303809e-01	0.081
Depurination	R-HSA-73927	8.303809e-01	0.081
Purine salvage	R-HSA-74217	8.303809e-01	0.081
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	8.303809e-01	0.081
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	8.303809e-01	0.081
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.303809e-01	0.081
Circadian clock	R-HSA-9909396	8.339433e-01	0.079
Plasma lipoprotein clearance	R-HSA-8964043	8.369475e-01	0.077
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	8.369475e-01	0.077
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.381722e-01	0.077
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.432602e-01	0.074
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	8.432602e-01	0.074
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	8.432602e-01	0.074
Generation of second messenger molecules	R-HSA-202433	8.432602e-01	0.074
Aflatoxin activation and detoxification	R-HSA-5423646	8.493290e-01	0.071
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.493290e-01	0.071
Maturation of spike protein	R-HSA-9694548	8.493290e-01	0.071
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.493290e-01	0.071
Stimuli-sensing channels	R-HSA-2672351	8.511596e-01	0.070
ABC transporter disorders	R-HSA-5619084	8.522869e-01	0.069
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.551631e-01	0.068
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.551631e-01	0.068
Cleavage of the damaged pyrimidine	R-HSA-110329	8.607716e-01	0.065
Depyrimidination	R-HSA-73928	8.607716e-01	0.065
TBC/RABGAPs	R-HSA-8854214	8.661634e-01	0.062
Cyclin D associated events in G1	R-HSA-69231	8.713466e-01	0.060
G1 Phase	R-HSA-69236	8.713466e-01	0.060
Surfactant metabolism	R-HSA-5683826	8.713466e-01	0.060
Somitogenesis	R-HSA-9824272	8.763294e-01	0.057
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.763294e-01	0.057
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.763294e-01	0.057
FCERI mediated NF-kB activation	R-HSA-2871837	8.807397e-01	0.055
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	8.811195e-01	0.055
Condensation of Prophase Chromosomes	R-HSA-2299718	8.811195e-01	0.055
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.811195e-01	0.055
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.811195e-01	0.055
Regulation of pyruvate metabolism	R-HSA-9861718	8.811195e-01	0.055
Regulation of TNFR1 signaling	R-HSA-5357905	8.811195e-01	0.055
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.857243e-01	0.053
Synthesis of PC	R-HSA-1483191	8.857243e-01	0.053
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	8.857243e-01	0.053
Intraflagellar transport	R-HSA-5620924	8.901511e-01	0.051
Plasma lipoprotein remodeling	R-HSA-8963899	8.901511e-01	0.051
NGF-stimulated transcription	R-HSA-9031628	8.901511e-01	0.051
Metal ion SLC transporters	R-HSA-425410	8.901511e-01	0.051
GPCR downstream signalling	R-HSA-388396	8.970709e-01	0.047
Regulation of RAS by GAPs	R-HSA-5658442	8.984975e-01	0.046
PI3K Cascade	R-HSA-109704	8.984975e-01	0.046
Azathioprine ADME	R-HSA-9748787	8.984975e-01	0.046
Translation	R-HSA-72766	9.006740e-01	0.045
Activation of NF-kappaB in B cells	R-HSA-1169091	9.024302e-01	0.045
HCMV Infection	R-HSA-9609646	9.067490e-01	0.043
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	9.098450e-01	0.041
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	9.098450e-01	0.041
Amino acids regulate mTORC1	R-HSA-9639288	9.098450e-01	0.041
Nucleotide biosynthesis	R-HSA-8956320	9.098450e-01	0.041
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.102715e-01	0.041
Ion channel transport	R-HSA-983712	9.121140e-01	0.040
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.133386e-01	0.039
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.133386e-01	0.039
Mitochondrial protein degradation	R-HSA-9837999	9.157966e-01	0.038
Paracetamol ADME	R-HSA-9753281	9.166971e-01	0.038
NRAGE signals death through JNK	R-HSA-193648	9.199256e-01	0.036
IRS-mediated signalling	R-HSA-112399	9.230292e-01	0.035
Dectin-2 family	R-HSA-5621480	9.230292e-01	0.035
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	9.230292e-01	0.035
Regulation of insulin secretion	R-HSA-422356	9.282434e-01	0.032
Peroxisomal protein import	R-HSA-9033241	9.288807e-01	0.032
Deadenylation-dependent mRNA decay	R-HSA-429914	9.288807e-01	0.032
Sialic acid metabolism	R-HSA-4085001	9.288807e-01	0.032
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.288807e-01	0.032
Degradation of the extracellular matrix	R-HSA-1474228	9.307317e-01	0.031
Formation of paraxial mesoderm	R-HSA-9793380	9.342880e-01	0.030
IRS-related events triggered by IGF1R	R-HSA-2428928	9.342880e-01	0.030
Endogenous sterols	R-HSA-211976	9.342880e-01	0.030
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.342880e-01	0.030
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.352441e-01	0.029
Metabolism of nucleotides	R-HSA-15869	9.373178e-01	0.028
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.392848e-01	0.027
G1/S DNA Damage Checkpoints	R-HSA-69615	9.392848e-01	0.027
tRNA processing	R-HSA-72306	9.395781e-01	0.027
Xenobiotics	R-HSA-211981	9.416390e-01	0.026
Signaling by NOTCH	R-HSA-157118	9.427719e-01	0.026
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	9.427782e-01	0.026
Activation of HOX genes during differentiation	R-HSA-5619507	9.427782e-01	0.026
RSV-host interactions	R-HSA-9833110	9.427782e-01	0.026
Platelet homeostasis	R-HSA-418346	9.463875e-01	0.024
Kidney development	R-HSA-9830369	9.481688e-01	0.023
Nicotinate metabolism	R-HSA-196807	9.481688e-01	0.023
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.481688e-01	0.023
Signaling by GPCR	R-HSA-372790	9.487151e-01	0.023
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	9.501791e-01	0.022
Cyclin E associated events during G1/S transition	R-HSA-69202	9.539691e-01	0.020
Retinoid metabolism and transport	R-HSA-975634	9.557547e-01	0.020
Metabolism of cofactors	R-HSA-8978934	9.557547e-01	0.020
Metabolism of porphyrins	R-HSA-189445	9.557547e-01	0.020
Purine catabolism	R-HSA-74259	9.574712e-01	0.019
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	9.574712e-01	0.019
Visual phototransduction	R-HSA-2187338	9.575793e-01	0.019
Diseases of carbohydrate metabolism	R-HSA-5663084	9.591212e-01	0.018
Gastrulation	R-HSA-9758941	9.600010e-01	0.018
Neddylation	R-HSA-8951664	9.604939e-01	0.018
Signaling by NOTCH4	R-HSA-9013694	9.607072e-01	0.017
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.611626e-01	0.017
Citric acid cycle (TCA cycle)	R-HSA-71403	9.622318e-01	0.017
Protein localization	R-HSA-9609507	9.644603e-01	0.016
Peptide hormone metabolism	R-HSA-2980736	9.650634e-01	0.015
Metabolism of proteins	R-HSA-392499	9.660700e-01	0.015
SLC-mediated transport of organic anions	R-HSA-9955298	9.664603e-01	0.015
Extracellular matrix organization	R-HSA-1474244	9.665034e-01	0.015
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.677621e-01	0.014
HCMV Late Events	R-HSA-9610379	9.684486e-01	0.014
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.694234e-01	0.013
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.702161e-01	0.013
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.702161e-01	0.013
Maternal to zygotic transition (MZT)	R-HSA-9816359	9.714021e-01	0.013
Cytoprotection by HMOX1	R-HSA-9707564	9.724836e-01	0.012
Peroxisomal lipid metabolism	R-HSA-390918	9.735518e-01	0.012
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.755658e-01	0.011
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.765145e-01	0.010
Pyruvate metabolism	R-HSA-70268	9.774265e-01	0.010
Keratinization	R-HSA-6805567	9.778519e-01	0.010
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.783032e-01	0.010
ER-Phagosome pathway	R-HSA-1236974	9.791458e-01	0.009
Cardiac conduction	R-HSA-5576891	9.795806e-01	0.009
Class B/2 (Secretin family receptors)	R-HSA-373080	9.799558e-01	0.009
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.805514e-01	0.009
Collagen formation	R-HSA-1474290	9.835581e-01	0.007
Drug ADME	R-HSA-9748784	9.842381e-01	0.007
Synthesis of bile acids and bile salts	R-HSA-192105	9.870380e-01	0.006
G alpha (i) signalling events	R-HSA-418594	9.871942e-01	0.006
Transcriptional regulation by RUNX1	R-HSA-8878171	9.874798e-01	0.005
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.907133e-01	0.004
Asparagine N-linked glycosylation	R-HSA-446203	9.909450e-01	0.004
Antigen processing-Cross presentation	R-HSA-1236975	9.912812e-01	0.004
Co-inhibition by PD-1	R-HSA-389948	9.918743e-01	0.004
Bile acid and bile salt metabolism	R-HSA-194068	9.919462e-01	0.004
Sphingolipid metabolism	R-HSA-428157	9.921279e-01	0.003
Antimicrobial peptides	R-HSA-6803157	9.922595e-01	0.003
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.938995e-01	0.003
Role of phospholipids in phagocytosis	R-HSA-2029485	9.938995e-01	0.003
Rab regulation of trafficking	R-HSA-9007101	9.943650e-01	0.002
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.944914e-01	0.002
Nucleotide catabolism	R-HSA-8956319	9.966373e-01	0.001
Bacterial Infection Pathways	R-HSA-9824439	9.967413e-01	0.001
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.970051e-01	0.001
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.970151e-01	0.001
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.970705e-01	0.001
Peptide ligand-binding receptors	R-HSA-375276	9.972782e-01	0.001
SLC-mediated transmembrane transport	R-HSA-425407	9.972963e-01	0.001
Glycosaminoglycan metabolism	R-HSA-1630316	9.978778e-01	0.001
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.982891e-01	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	9.985153e-01	0.001
Transport of small molecules	R-HSA-382551	9.986132e-01	0.001
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.990198e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.992926e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.993938e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.994392e-01	0.000
Respiratory electron transport	R-HSA-611105	9.995919e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.996787e-01	0.000
GPCR ligand binding	R-HSA-500792	9.998798e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999308e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999471e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999832e-01	0.000
Diseases of metabolism	R-HSA-5668914	9.999969e-01	0.000
Biological oxidations	R-HSA-211859	9.999999e-01	0.000
Metabolism of lipids	R-HSA-556833	9.999999e-01	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955
Cell Cycle, Mitotic	R-HSA-69278	1.110223e-16	15.955
Cell Cycle Checkpoints	R-HSA-69620	4.485301e-14	13.348
M Phase	R-HSA-68886	1.215694e-13	12.915
Separation of Sister Chromatids	R-HSA-2467813	3.060552e-12	11.514
Mitotic Anaphase	R-HSA-68882	6.872947e-12	11.163
Mitotic Metaphase and Anaphase	R-HSA-2555396	7.829293e-12	11.106
Mitotic Prometaphase	R-HSA-68877	5.678491e-11	10.246
G2/M Checkpoints	R-HSA-69481	6.147474e-10	9.211
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	8.674544e-10	9.062
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.932477e-09	8.533
ISG15 antiviral mechanism	R-HSA-1169408	3.926973e-09	8.406
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	7.394223e-09	8.131
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.045729e-07	6.981
G2/M Transition	R-HSA-69275	1.422058e-07	6.847
Mitotic G2-G2/M phases	R-HSA-453274	1.748232e-07	6.757
Aggrephagy	R-HSA-9646399	2.230942e-07	6.652
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.640561e-07	6.439
G2/M DNA damage checkpoint	R-HSA-69473	3.874613e-07	6.412
Regulation of CDH1 Function	R-HSA-9764561	3.895378e-07	6.409
Mitotic Spindle Checkpoint	R-HSA-69618	4.729772e-07	6.325
Interferon Signaling	R-HSA-913531	5.786560e-07	6.238
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	6.292346e-07	6.201
Amplification of signal from the kinetochores	R-HSA-141424	6.292346e-07	6.201
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.011049e-06	5.995
Transcriptional Regulation by TP53	R-HSA-3700989	1.487611e-06	5.828
Cellular responses to stimuli	R-HSA-8953897	1.521271e-06	5.818
Oncogenic MAPK signaling	R-HSA-6802957	2.237313e-06	5.650
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.226651e-06	5.491
Chaperone Mediated Autophagy	R-HSA-9613829	3.763067e-06	5.424
Signal Transduction	R-HSA-162582	4.033834e-06	5.394
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	5.804616e-06	5.236
NS1 Mediated Effects on Host Pathways	R-HSA-168276	6.089776e-06	5.215
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	6.275810e-06	5.202
Cellular responses to stress	R-HSA-2262752	7.579617e-06	5.120
DNA Double Strand Break Response	R-HSA-5693606	1.049041e-05	4.979
DNA Double-Strand Break Repair	R-HSA-5693532	1.197996e-05	4.922
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.271171e-05	4.896
Regulation of PTEN localization	R-HSA-8948747	1.513230e-05	4.820
Metabolism of RNA	R-HSA-8953854	1.479193e-05	4.830
Axon guidance	R-HSA-422475	2.163509e-05	4.665
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.523954e-05	4.598
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.568546e-05	4.590
Apoptosis	R-HSA-109581	2.690933e-05	4.570
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.897470e-05	4.538
Signaling downstream of RAS mutants	R-HSA-9649948	2.897470e-05	4.538
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.897470e-05	4.538
Signaling by RAS mutants	R-HSA-6802949	2.897470e-05	4.538
Cellular response to heat stress	R-HSA-3371556	2.984941e-05	4.525
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.220676e-05	4.492
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	3.263170e-05	4.486
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.314690e-05	4.480
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	3.899906e-05	4.409
Interactions of Rev with host cellular proteins	R-HSA-177243	3.899906e-05	4.409
Nuclear Envelope Breakdown	R-HSA-2980766	3.992927e-05	4.399
Transport of the SLBP independent Mature mRNA	R-HSA-159227	4.109166e-05	4.386
Gene expression (Transcription)	R-HSA-74160	4.496249e-05	4.347
Cytokine Signaling in Immune system	R-HSA-1280215	4.912037e-05	4.309
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	5.060772e-05	4.296
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	5.360623e-05	4.271
Selective autophagy	R-HSA-9663891	5.360623e-05	4.271
Signaling by RAF1 mutants	R-HSA-9656223	5.634960e-05	4.249
Nervous system development	R-HSA-9675108	5.795525e-05	4.237
Nuclear import of Rev protein	R-HSA-180746	6.194030e-05	4.208
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	6.425348e-05	4.192
Pexophagy	R-HSA-9664873	6.425348e-05	4.192
Processing of DNA double-strand break ends	R-HSA-5693607	7.175042e-05	4.144
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.384672e-05	4.077
Muscle contraction	R-HSA-397014	8.536110e-05	4.069
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.117623e-05	4.040
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	9.645608e-05	4.016
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.027860e-04	3.988
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.121780e-04	3.950
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.097156e-04	3.960
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.097156e-04	3.960
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.143777e-04	3.942
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.188910e-04	3.925
Host Interactions of HIV factors	R-HSA-162909	1.195711e-04	3.922
HIV Life Cycle	R-HSA-162587	1.311191e-04	3.882
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.313470e-04	3.882
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.455331e-04	3.837
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.455331e-04	3.837
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.455331e-04	3.837
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.564717e-04	3.806
SARS-CoV-1-host interactions	R-HSA-9692914	1.588141e-04	3.799
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.626255e-04	3.789
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.828021e-04	3.738
DNA Repair	R-HSA-73894	1.772650e-04	3.751
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.750460e-04	3.757
Signaling by ALK in cancer	R-HSA-9700206	1.750460e-04	3.757
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.855273e-04	3.732
Homology Directed Repair	R-HSA-5693538	2.001888e-04	3.699
IPs transport between nucleus and cytosol	R-HSA-1855170	2.138940e-04	3.670
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	2.208479e-04	3.656
Mitotic Prophase	R-HSA-68875	2.392427e-04	3.621
Hedgehog 'off' state	R-HSA-5610787	2.432339e-04	3.614
SARS-CoV-2-host interactions	R-HSA-9705683	2.440401e-04	3.613
Striated Muscle Contraction	R-HSA-390522	2.569855e-04	3.590
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.569855e-04	3.590
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	2.573719e-04	3.589
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.791715e-04	3.554
Myoclonic epilepsy of Lafora	R-HSA-3785653	2.815774e-04	3.550
Programmed Cell Death	R-HSA-5357801	3.039833e-04	3.517
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.366525e-04	3.473
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	3.435505e-04	3.464
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	3.648782e-04	3.438
NRIF signals cell death from the nucleus	R-HSA-205043	3.659723e-04	3.437
Signaling by NOTCH4	R-HSA-9013694	3.773348e-04	3.423
MAPK6/MAPK4 signaling	R-HSA-5687128	3.810451e-04	3.419
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.324060e-04	3.364
Regulation of TP53 Activity	R-HSA-5633007	4.209457e-04	3.376
Regulation of TP53 Degradation	R-HSA-6804757	4.314242e-04	3.365
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	4.567186e-04	3.340
Regulation of CDH1 Expression and Function	R-HSA-9764265	4.567186e-04	3.340
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.685316e-04	3.329
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	4.851825e-04	3.314
FLT3 signaling by CBL mutants	R-HSA-9706377	4.967938e-04	3.304
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	5.076421e-04	3.294
HIV Infection	R-HSA-162906	5.163969e-04	3.287
Apoptotic execution phase	R-HSA-75153	5.440393e-04	3.264
Downregulation of ERBB2 signaling	R-HSA-8863795	6.043409e-04	3.219
Macroautophagy	R-HSA-1632852	6.197263e-04	3.208
Stabilization of p53	R-HSA-69541	6.933107e-04	3.159
Adherens junctions interactions	R-HSA-418990	6.745956e-04	3.171
Regulation of BACH1 activity	R-HSA-9708530	6.326340e-04	3.199
Cell-Cell communication	R-HSA-1500931	6.791837e-04	3.168
Influenza Infection	R-HSA-168255	6.800132e-04	3.167
Autophagy	R-HSA-9612973	7.810517e-04	3.107
Maturation of protein E	R-HSA-9694493	8.143758e-04	3.089
Maturation of protein E	R-HSA-9683683	8.143758e-04	3.089
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	8.159482e-04	3.088
Regulation of localization of FOXO transcription factors	R-HSA-9614399	8.305336e-04	3.081
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	8.305336e-04	3.081
Cell junction organization	R-HSA-446728	8.591950e-04	3.066
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	9.035341e-04	3.044
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	9.309955e-04	3.031
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	9.908838e-04	3.004
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.005726e-03	2.998
MAP2K and MAPK activation	R-HSA-5674135	1.072489e-03	2.970
Switching of origins to a post-replicative state	R-HSA-69052	1.107581e-03	2.956
S Phase	R-HSA-69242	1.094755e-03	2.961
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.029778e-03	2.987
NF-kB is activated and signals survival	R-HSA-209560	1.125248e-03	2.949
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.125248e-03	2.949
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	1.194641e-03	2.923
Orc1 removal from chromatin	R-HSA-68949	1.194641e-03	2.923
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.288904e-03	2.890
Transport of connexons to the plasma membrane	R-HSA-190872	1.288904e-03	2.890
RNA Polymerase II Transcription	R-HSA-73857	1.332832e-03	2.875
PTEN Regulation	R-HSA-6807070	1.338350e-03	2.873
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.348126e-03	2.870
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.348126e-03	2.870
Smooth Muscle Contraction	R-HSA-445355	1.348126e-03	2.870
Dual Incision in GG-NER	R-HSA-5696400	1.375205e-03	2.862
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	1.375205e-03	2.862
p75NTR recruits signalling complexes	R-HSA-209543	1.491044e-03	2.827
VLDLR internalisation and degradation	R-HSA-8866427	1.491044e-03	2.827
Chaperonin-mediated protein folding	R-HSA-390466	1.553008e-03	2.809
Post NMDA receptor activation events	R-HSA-438064	1.553008e-03	2.809
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.595094e-03	2.797
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.595094e-03	2.797
Regulation of Apoptosis	R-HSA-169911	1.596535e-03	2.797
Cyclin D associated events in G1	R-HSA-69231	1.604291e-03	2.795
G1 Phase	R-HSA-69236	1.604291e-03	2.795
Gap junction trafficking	R-HSA-190828	1.604291e-03	2.795
EPHA-mediated growth cone collapse	R-HSA-3928663	1.697302e-03	2.770
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.697302e-03	2.770
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.703267e-03	2.769
Signaling by NOTCH3	R-HSA-9012852	1.703267e-03	2.769
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.953637e-03	2.709
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.953637e-03	2.709
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.953637e-03	2.709
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.953637e-03	2.709
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.907283e-03	2.720
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.953637e-03	2.709
Late Phase of HIV Life Cycle	R-HSA-162599	1.756319e-03	2.755
Glycogen synthesis	R-HSA-3322077	1.953637e-03	2.709
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.822361e-03	2.739
p75 NTR receptor-mediated signalling	R-HSA-193704	1.844388e-03	2.734
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.737653e-03	2.760
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.892083e-03	2.723
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.003898e-03	2.698
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	2.063508e-03	2.685
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.063508e-03	2.685
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.094478e-03	2.679
Transcriptional Regulation by MECP2	R-HSA-8986944	2.203899e-03	2.657
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.279427e-03	2.642
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.370001e-03	2.625
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.370001e-03	2.625
Late endosomal microautophagy	R-HSA-9615710	2.351676e-03	2.629
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.351676e-03	2.629
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	2.329426e-03	2.633
Protein folding	R-HSA-391251	2.605020e-03	2.584
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.583832e-03	2.588
EPH-Ephrin signaling	R-HSA-2682334	2.605020e-03	2.584
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	2.346277e-03	2.630
MAPK family signaling cascades	R-HSA-5683057	2.672618e-03	2.573
Recycling pathway of L1	R-HSA-437239	2.329426e-03	2.633
Downregulation of ERBB4 signaling	R-HSA-1253288	2.583832e-03	2.588
Metabolism of non-coding RNA	R-HSA-194441	2.640227e-03	2.578
snRNP Assembly	R-HSA-191859	2.640227e-03	2.578
MITF-M-regulated melanocyte development	R-HSA-9730414	2.359824e-03	2.627
Modulation by Mtb of host immune system	R-HSA-9637628	2.583832e-03	2.588
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.583832e-03	2.588
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.804845e-03	2.552
Regulation of mitotic cell cycle	R-HSA-453276	2.804845e-03	2.552
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	2.849808e-03	2.545
Developmental Biology	R-HSA-1266738	2.874841e-03	2.541
Kinesins	R-HSA-983189	2.929295e-03	2.533
DNA Damage Bypass	R-HSA-73893	2.942660e-03	2.531
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.942660e-03	2.531
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.942660e-03	2.531
Degradation of CDH1	R-HSA-9766229	2.942660e-03	2.531
Gap junction trafficking and regulation	R-HSA-157858	2.942660e-03	2.531
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	3.185068e-03	2.497
Regulation of RAS by GAPs	R-HSA-5658442	3.293652e-03	2.482
Cap-dependent Translation Initiation	R-HSA-72737	3.237942e-03	2.490
Eukaryotic Translation Initiation	R-HSA-72613	3.237942e-03	2.490
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	3.517420e-03	2.454
mTORC1-mediated signalling	R-HSA-166208	3.398801e-03	2.469
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.112436e-03	2.507
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	3.580392e-03	2.446
p75NTR signals via NF-kB	R-HSA-193639	3.112436e-03	2.507
Negative regulation of NOTCH4 signaling	R-HSA-9604323	3.159454e-03	2.500
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.583011e-03	2.446
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	3.398801e-03	2.469
Activation of BAD and translocation to mitochondria	R-HSA-111447	3.112436e-03	2.507
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.398801e-03	2.469
Spry regulation of FGF signaling	R-HSA-1295596	3.112436e-03	2.507
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	3.185068e-03	2.497
Cell-extracellular matrix interactions	R-HSA-446353	3.112436e-03	2.507
tRNA processing in the nucleus	R-HSA-6784531	3.583011e-03	2.446
Signaling by Hedgehog	R-HSA-5358351	2.992771e-03	2.524
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	3.580392e-03	2.446
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	3.112436e-03	2.507
Synthesis of DNA	R-HSA-69239	3.689594e-03	2.433
Cell-cell junction organization	R-HSA-421270	3.728955e-03	2.428
Regulation of NF-kappa B signaling	R-HSA-9758274	3.860816e-03	2.413
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.950614e-03	2.403
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.950614e-03	2.403
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	3.964819e-03	2.402
Negative regulation of MAPK pathway	R-HSA-5675221	4.043479e-03	2.393
Transcriptional regulation by RUNX3	R-HSA-8878159	4.179795e-03	2.379
Regulation of MECP2 expression and activity	R-HSA-9022692	4.226994e-03	2.374
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	4.226994e-03	2.374
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	4.807776e-03	2.318
Diseases of Telomere Maintenance	R-HSA-9673013	4.807776e-03	2.318
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	4.807776e-03	2.318
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	4.807776e-03	2.318
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	4.807776e-03	2.318
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	4.807776e-03	2.318
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	5.519545e-03	2.258
AURKA Activation by TPX2	R-HSA-8854518	5.234860e-03	2.281
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	4.657042e-03	2.332
DNA Damage Recognition in GG-NER	R-HSA-5696394	4.835721e-03	2.316
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	5.508170e-03	2.259
Resolution of D-Loop Structures	R-HSA-5693537	4.835721e-03	2.316
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	4.729848e-03	2.325
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	5.712928e-03	2.243
Generic Transcription Pathway	R-HSA-212436	4.825075e-03	2.316
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	4.729848e-03	2.325
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	4.729848e-03	2.325
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	4.729848e-03	2.325
Josephin domain DUBs	R-HSA-5689877	4.657042e-03	2.332
Signaling by Hippo	R-HSA-2028269	5.729425e-03	2.242
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	4.727755e-03	2.325
Neurodegenerative Diseases	R-HSA-8863678	4.727755e-03	2.325
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	5.508170e-03	2.259
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	5.038640e-03	2.298
Glycogen storage diseases	R-HSA-3229121	5.729425e-03	2.242
Vpu mediated degradation of CD4	R-HSA-180534	4.835721e-03	2.316
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	5.508170e-03	2.259
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	4.657042e-03	2.332
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.712928e-03	2.243
Glycolysis	R-HSA-70171	5.215200e-03	2.283
Signaling by ROBO receptors	R-HSA-376176	5.686672e-03	2.245
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.836098e-03	2.234
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	6.012893e-03	2.221
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	6.021692e-03	2.220
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	6.144204e-03	2.212
Signaling by EGFR	R-HSA-177929	6.144204e-03	2.212
PKR-mediated signaling	R-HSA-9833482	6.158838e-03	2.211
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	6.248300e-03	2.204
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	6.248300e-03	2.204
Oncogene Induced Senescence	R-HSA-2559585	6.248300e-03	2.204
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.248300e-03	2.204
Fanconi Anemia Pathway	R-HSA-6783310	6.372116e-03	2.196
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	6.372116e-03	2.196
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	6.372116e-03	2.196
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	6.372116e-03	2.196
Signaling by EGFR in Cancer	R-HSA-1643713	6.404119e-03	2.194
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	6.404119e-03	2.194
Metalloprotease DUBs	R-HSA-5689901	6.404119e-03	2.194
Vif-mediated degradation of APOBEC3G	R-HSA-180585	7.060087e-03	2.151
Diseases of DNA repair	R-HSA-9675135	7.087394e-03	2.150
Intracellular signaling by second messengers	R-HSA-9006925	7.092434e-03	2.149
Assembly of the pre-replicative complex	R-HSA-68867	7.385826e-03	2.132
Dual incision in TC-NER	R-HSA-6782135	7.427645e-03	2.129
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.430795e-03	2.129
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	7.430795e-03	2.129
Mitotic Telophase/Cytokinesis	R-HSA-68884	7.629105e-03	2.118
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	7.629105e-03	2.118
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	7.629105e-03	2.118
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	7.947512e-03	2.100
Ovarian tumor domain proteases	R-HSA-5689896	7.947512e-03	2.100
Degradation of DVL	R-HSA-4641258	7.947512e-03	2.100
Degradation of AXIN	R-HSA-4641257	7.947512e-03	2.100
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	7.947512e-03	2.100
HCMV Early Events	R-HSA-9609690	8.123783e-03	2.090
Translesion Synthesis by POLH	R-HSA-110320	8.158761e-03	2.088
Regulation of signaling by CBL	R-HSA-912631	8.158761e-03	2.088
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	8.697727e-03	2.061
Transcriptional regulation by small RNAs	R-HSA-5578749	8.766162e-03	2.057
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	8.766162e-03	2.057
SARS-CoV Infections	R-HSA-9679506	8.801287e-03	2.055
Signaling by ERBB2	R-HSA-1227986	8.906328e-03	2.050
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.914551e-03	2.050
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.119414e-03	2.040
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	9.607092e-03	2.017
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	9.499216e-03	2.022
Centrosome maturation	R-HSA-380287	1.110479e-02	1.954
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.110324e-02	1.955
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.110479e-02	1.954
PKMTs methylate histone lysines	R-HSA-3214841	1.233267e-02	1.909
Membrane binding and targetting of GAG proteins	R-HSA-174490	1.163609e-02	1.934
HSF1-dependent transactivation	R-HSA-3371571	1.160595e-02	1.935
Clathrin-mediated endocytosis	R-HSA-8856828	9.513623e-03	2.022
Chromatin modifying enzymes	R-HSA-3247509	1.224041e-02	1.912
Breakdown of the nuclear lamina	R-HSA-352238	1.046230e-02	1.980
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	1.160595e-02	1.935
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.597431e-03	2.018
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	9.495620e-03	2.022
DNA Replication Pre-Initiation	R-HSA-69002	1.022296e-02	1.990
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	9.607092e-03	2.017
G1/S DNA Damage Checkpoints	R-HSA-69615	1.152893e-02	1.938
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.965155e-03	2.002
Negative regulation of MET activity	R-HSA-6807004	9.607092e-03	2.017
Cilium Assembly	R-HSA-5617833	1.209458e-02	1.917
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	9.495620e-03	2.022
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	9.495620e-03	2.022
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.122299e-02	1.950
Regulation of RUNX3 expression and activity	R-HSA-8941858	1.110324e-02	1.955
Hh mutants are degraded by ERAD	R-HSA-5362768	1.233267e-02	1.909
Viral Messenger RNA Synthesis	R-HSA-168325	9.724377e-03	2.012
Activation of BH3-only proteins	R-HSA-114452	1.098729e-02	1.959
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.163609e-02	1.934
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	9.495620e-03	2.022
IRAK1 recruits IKK complex	R-HSA-937039	9.495620e-03	2.022
Semaphorin interactions	R-HSA-373755	1.152893e-02	1.938
SARS-CoV-1 Infection	R-HSA-9678108	1.188926e-02	1.925
EGFR downregulation	R-HSA-182971	1.242278e-02	1.906
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	1.242278e-02	1.906
Evasion by RSV of host interferon responses	R-HSA-9833109	1.242278e-02	1.906
mRNA 3'-end processing	R-HSA-72187	1.271824e-02	1.896
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	1.271824e-02	1.896
ER-Phagosome pathway	R-HSA-1236974	1.292755e-02	1.888
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.301479e-02	1.886
Estrogen-dependent gene expression	R-HSA-9018519	1.316836e-02	1.880
Degradation of CRY and PER proteins	R-HSA-9932298	1.365724e-02	1.865
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.365724e-02	1.865
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.365724e-02	1.865
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.365724e-02	1.865
Potential therapeutics for SARS	R-HSA-9679191	1.369182e-02	1.864
MITF-M-dependent gene expression	R-HSA-9856651	1.369182e-02	1.864
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.383119e-02	1.859
G alpha (12/13) signalling events	R-HSA-416482	1.388810e-02	1.857
Regulation of PTEN stability and activity	R-HSA-8948751	1.390670e-02	1.857
Diseases of mitotic cell cycle	R-HSA-9675126	1.398506e-02	1.854
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.406379e-02	1.852
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.406379e-02	1.852
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.406379e-02	1.852
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.406379e-02	1.852
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.491584e-02	1.826
Cohesin Loading onto Chromatin	R-HSA-2470946	1.491584e-02	1.826
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.508068e-02	1.822
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.511605e-02	1.821
Translation initiation complex formation	R-HSA-72649	1.517411e-02	1.819
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.567931e-02	1.805
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.567931e-02	1.805
DNA Replication	R-HSA-69306	1.586996e-02	1.799
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.601399e-02	1.796
Viral Infection Pathways	R-HSA-9824446	1.603392e-02	1.795
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.660663e-02	1.780
Hh mutants abrogate ligand secretion	R-HSA-5387390	1.660663e-02	1.780
Death Receptor Signaling	R-HSA-73887	1.665262e-02	1.779
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.679042e-02	1.775
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.679042e-02	1.775
Translesion synthesis by REV1	R-HSA-110312	1.679042e-02	1.775
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.679042e-02	1.775
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	1.679042e-02	1.775
RAF/MAP kinase cascade	R-HSA-5673001	1.707451e-02	1.768
Membrane Trafficking	R-HSA-199991	1.725916e-02	1.763
Ribosomal scanning and start codon recognition	R-HSA-72702	1.795670e-02	1.746
Ion homeostasis	R-HSA-5578775	1.795670e-02	1.746
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.799152e-02	1.745
Regulation of TP53 Expression	R-HSA-6804754	1.799152e-02	1.745
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.799152e-02	1.745
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.799152e-02	1.745
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.799152e-02	1.745
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.799152e-02	1.745
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.799152e-02	1.745
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.799152e-02	1.745
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.799152e-02	1.745
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.799152e-02	1.745
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.799152e-02	1.745
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.799152e-02	1.745
EPHB-mediated forward signaling	R-HSA-3928662	1.823861e-02	1.739
Glucose metabolism	R-HSA-70326	1.836827e-02	1.736
Formation of annular gap junctions	R-HSA-196025	1.913415e-02	1.718
RAF activation	R-HSA-5673000	1.948326e-02	1.710
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.948326e-02	1.710
Gap junction assembly	R-HSA-190861	1.948326e-02	1.710
Signaling by NOTCH2	R-HSA-1980145	1.948326e-02	1.710
Translesion synthesis by POLI	R-HSA-5656121	1.982602e-02	1.703
Negative regulation of FLT3	R-HSA-9706369	1.982602e-02	1.703
Cyclin E associated events during G1/S transition	R-HSA-69202	1.984299e-02	1.702
DAG and IP3 signaling	R-HSA-1489509	1.998005e-02	1.699
Defective CFTR causes cystic fibrosis	R-HSA-5678895	1.998005e-02	1.699
Asymmetric localization of PCP proteins	R-HSA-4608870	1.998005e-02	1.699
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.097646e-02	1.678
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.097646e-02	1.678
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	2.108729e-02	1.676
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.160219e-02	1.666
MAPK1/MAPK3 signaling	R-HSA-5684996	2.164910e-02	1.665
Chromatin organization	R-HSA-4839726	2.173079e-02	1.663
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	2.183424e-02	1.661
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	2.719653e-02	1.565
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	2.719653e-02	1.565
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.719653e-02	1.565
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.719653e-02	1.565
Gap junction degradation	R-HSA-190873	2.394434e-02	1.621
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	2.934691e-02	1.532
Disorders of Developmental Biology	R-HSA-9675151	2.317904e-02	1.635
Translesion synthesis by POLK	R-HSA-5655862	2.317904e-02	1.635
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	2.786198e-02	1.555
Regulation of PTEN gene transcription	R-HSA-8943724	2.458610e-02	1.609
Nonsense-Mediated Decay (NMD)	R-HSA-927802	2.697112e-02	1.569
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	2.697112e-02	1.569
Ribosome-associated quality control	R-HSA-9948299	2.965212e-02	1.528
Chromosome Maintenance	R-HSA-73886	2.273061e-02	1.643
Meiosis	R-HSA-1500620	2.237489e-02	1.650
UCH proteinases	R-HSA-5689603	2.984981e-02	1.525
Myogenesis	R-HSA-525793	2.486869e-02	1.604
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.286900e-02	1.641
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.285934e-02	1.641
Regulation of FZD by ubiquitination	R-HSA-4641263	2.685629e-02	1.571
RNA Polymerase II Transcription Termination	R-HSA-73856	2.647957e-02	1.577
Calmodulin induced events	R-HSA-111933	2.387145e-02	1.622
Cellular Senescence	R-HSA-2559583	2.835766e-02	1.547
CaM pathway	R-HSA-111997	2.387145e-02	1.622
ESR-mediated signaling	R-HSA-8939211	2.471001e-02	1.607
Negative regulation of FGFR3 signaling	R-HSA-5654732	3.107448e-02	1.508
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.086302e-02	1.511
Sema4D in semaphorin signaling	R-HSA-400685	2.209022e-02	1.656
Transcriptional regulation by RUNX1	R-HSA-8878171	2.914513e-02	1.535
Cellular responses to mechanical stimuli	R-HSA-9855142	2.992264e-02	1.524
Regulation of RUNX2 expression and activity	R-HSA-8939902	2.647957e-02	1.577
G1/S Transition	R-HSA-69206	2.921253e-02	1.534
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.107448e-02	1.508
FLT3 signaling in disease	R-HSA-9682385	2.387145e-02	1.622
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.853623e-02	1.545
ER Quality Control Compartment (ERQC)	R-HSA-901032	2.786198e-02	1.555
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.810417e-02	1.551
Activation of NF-kappaB in B cells	R-HSA-1169091	3.290178e-02	1.483
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.086302e-02	1.511
Hedgehog ligand biogenesis	R-HSA-5358346	3.290178e-02	1.483
Signaling by Interleukins	R-HSA-449147	3.217139e-02	1.493
Plasma lipoprotein clearance	R-HSA-8964043	3.161924e-02	1.500
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	3.450998e-02	1.462
Termination of translesion DNA synthesis	R-HSA-5656169	3.450998e-02	1.462
Negative regulation of FGFR4 signaling	R-HSA-5654733	3.450998e-02	1.462
Glycogen metabolism	R-HSA-8982491	3.452633e-02	1.462
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.477644e-02	1.459
Cellular response to hypoxia	R-HSA-1234174	3.506486e-02	1.455
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	3.506486e-02	1.455
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	3.520294e-02	1.453
IKK complex recruitment mediated by RIP1	R-HSA-937041	3.520294e-02	1.453
STING mediated induction of host immune responses	R-HSA-1834941	3.520294e-02	1.453
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	3.549347e-02	1.450
Opioid Signalling	R-HSA-111885	3.561304e-02	1.448
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.561304e-02	1.448
Response of endothelial cells to shear stress	R-HSA-9860931	3.561304e-02	1.448
L1CAM interactions	R-HSA-373760	3.651207e-02	1.438
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	3.760046e-02	1.425
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	3.789353e-02	1.421
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	3.789353e-02	1.421
Ub-specific processing proteases	R-HSA-5689880	3.937600e-02	1.405
Nucleotide Excision Repair	R-HSA-5696398	3.945275e-02	1.404
Formation of definitive endoderm	R-HSA-9823730	3.987825e-02	1.399
G-protein mediated events	R-HSA-112040	3.999169e-02	1.398
SARS-CoV-2 Infection	R-HSA-9694516	4.021275e-02	1.396
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.190726e-02	1.378
Budding and maturation of HIV virion	R-HSA-162588	4.206192e-02	1.376
Gene Silencing by RNA	R-HSA-211000	4.357124e-02	1.361
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.425907e-02	1.354
MTOR signalling	R-HSA-165159	4.425907e-02	1.354
Ca-dependent events	R-HSA-111996	4.425907e-02	1.354
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	4.471669e-02	1.350
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	4.475102e-02	1.349
Early Phase of HIV Life Cycle	R-HSA-162594	4.488974e-02	1.348
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.488974e-02	1.348
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	4.488974e-02	1.348
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	4.488974e-02	1.348
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	4.488974e-02	1.348
Deubiquitination	R-HSA-5688426	4.510937e-02	1.346
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.573742e-02	1.340
Antigen processing-Cross presentation	R-HSA-1236975	4.573742e-02	1.340
G0 and Early G1	R-HSA-1538133	4.618272e-02	1.336
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.618272e-02	1.336
Signaling by NOTCH	R-HSA-157118	4.670593e-02	1.331
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	4.719445e-02	1.326
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.821212e-02	1.317
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	4.904403e-02	1.309
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	4.904403e-02	1.309
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	4.947181e-02	1.306
Loss of Function of TP53 in Cancer	R-HSA-9723907	4.947181e-02	1.306
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	4.947181e-02	1.306
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	4.991271e-02	1.302
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.991271e-02	1.302
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.991271e-02	1.302
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.991271e-02	1.302
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	4.991271e-02	1.302
Nectin/Necl trans heterodimerization	R-HSA-420597	4.991271e-02	1.302
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	5.023683e-02	1.299
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	5.023683e-02	1.299
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	5.023683e-02	1.299
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	5.023683e-02	1.299
Assembly Of The HIV Virion	R-HSA-175474	5.023683e-02	1.299
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	5.023683e-02	1.299
Signaling by PDGFR in disease	R-HSA-9671555	5.023683e-02	1.299
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	5.023683e-02	1.299
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	5.023683e-02	1.299
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	5.046168e-02	1.297
Regulation of necroptotic cell death	R-HSA-5675482	5.053530e-02	1.296
Negative regulation of FGFR1 signaling	R-HSA-5654726	5.053530e-02	1.296
Activation of ATR in response to replication stress	R-HSA-176187	5.053530e-02	1.296
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	5.117908e-02	1.291
Cargo trafficking to the periciliary membrane	R-HSA-5620920	5.117908e-02	1.291
Hedgehog 'on' state	R-HSA-5632684	5.117908e-02	1.291
Glucagon signaling in metabolic regulation	R-HSA-163359	5.512027e-02	1.259
Inositol phosphate metabolism	R-HSA-1483249	5.513471e-02	1.259
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	5.554879e-02	1.255
Nucleosome assembly	R-HSA-774815	5.554879e-02	1.255
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	5.554879e-02	1.255
PIP3 activates AKT signaling	R-HSA-1257604	5.585869e-02	1.253
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	5.591766e-02	1.252
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.673228e-02	1.246
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	5.673228e-02	1.246
Signaling by VEGF	R-HSA-194138	5.732819e-02	1.242
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.993766e-02	1.222
Mitophagy	R-HSA-5205647	5.993766e-02	1.222
Calnexin/calreticulin cycle	R-HSA-901042	5.993766e-02	1.222
Diseases of programmed cell death	R-HSA-9645723	6.250412e-02	1.204
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	6.309742e-02	1.200
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.309742e-02	1.200
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	6.309742e-02	1.200
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.309742e-02	1.200
Regulation of CDH19 Expression and Function	R-HSA-9764302	6.309742e-02	1.200
Interleukin-1 signaling	R-HSA-9020702	6.312248e-02	1.200
HCMV Infection	R-HSA-9609646	6.322012e-02	1.199
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	6.395541e-02	1.194
Non-integrin membrane-ECM interactions	R-HSA-3000171	6.420828e-02	1.192
PLC beta mediated events	R-HSA-112043	6.493406e-02	1.188
Regulation of PD-L1(CD274) expression	R-HSA-9909648	6.716113e-02	1.173
rRNA processing in the nucleus and cytosol	R-HSA-8868773	6.716434e-02	1.173
Interleukin-12 signaling	R-HSA-9020591	6.775951e-02	1.169
Deadenylation of mRNA	R-HSA-429947	6.826700e-02	1.166
Intraflagellar transport	R-HSA-5620924	6.842392e-02	1.165
HSF1 activation	R-HSA-3371511	7.026688e-02	1.153
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	7.229418e-02	1.141
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.302093e-02	1.137
Signaling by PTK6	R-HSA-8848021	7.302093e-02	1.137
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	7.302093e-02	1.137
Reproduction	R-HSA-1474165	7.302588e-02	1.137
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	7.368855e-02	1.133
G beta:gamma signalling through BTK	R-HSA-8964315	7.368855e-02	1.133
Sema3A PAK dependent Axon repulsion	R-HSA-399954	7.368855e-02	1.133
Epigenetic regulation of gene expression	R-HSA-212165	7.489141e-02	1.126
SWI/SNF chromatin remodelers	R-HSA-9932451	7.492598e-02	1.125
ATP-dependent chromatin remodelers	R-HSA-9932444	7.492598e-02	1.125
Long-term potentiation	R-HSA-9620244	7.492598e-02	1.125
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	9.649901e-02	1.015
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	9.649901e-02	1.015
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	9.649901e-02	1.015
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	9.649901e-02	1.015
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	9.649901e-02	1.015
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	1.412023e-01	0.850
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	1.412023e-01	0.850
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	1.412023e-01	0.850
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	1.412023e-01	0.850
PTEN Loss of Function in Cancer	R-HSA-5674404	1.412023e-01	0.850
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	1.412023e-01	0.850
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	1.412023e-01	0.850
MECP2 regulates transcription factors	R-HSA-9022707	9.239709e-02	1.034
Recycling of eIF2:GDP	R-HSA-72731	9.239709e-02	1.034
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	9.239709e-02	1.034
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	1.082566e-01	0.966
Signaling by MRAS-complex mutants	R-HSA-9660537	1.082566e-01	0.966
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.082566e-01	0.966
ALK mutants bind TKIs	R-HSA-9700645	1.247693e-01	0.904
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.418320e-01	0.848
2-LTR circle formation	R-HSA-164843	1.418320e-01	0.848
Folding of actin by CCT/TriC	R-HSA-390450	1.418320e-01	0.848
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	8.291408e-02	1.081
G beta:gamma signalling through CDC42	R-HSA-8964616	9.260688e-02	1.033
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	9.260688e-02	1.033
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.132944e-01	0.946
PKA activation in glucagon signalling	R-HSA-164378	1.132944e-01	0.946
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.918121e-02	1.050
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.355440e-01	0.868
Phase 0 - rapid depolarisation	R-HSA-5576892	9.676225e-02	1.014
Meiotic synapsis	R-HSA-1221632	9.339784e-02	1.030
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.427405e-01	0.845
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	7.587801e-02	1.120
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.354301e-01	0.868
Formation of a pool of free 40S subunits	R-HSA-72689	9.488367e-02	1.023
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	1.405241e-01	0.852
Regulation of endogenous retroelements	R-HSA-9842860	1.257192e-01	0.901
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.127874e-01	0.948
G-protein beta:gamma signalling	R-HSA-397795	1.388323e-01	0.858
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.110105e-01	0.955
Regulation of CDH11 function	R-HSA-9762292	1.418320e-01	0.848
Attenuation phase	R-HSA-3371568	9.365238e-02	1.028
Peptide chain elongation	R-HSA-156902	1.246548e-01	0.904
GP1b-IX-V activation signalling	R-HSA-430116	1.247693e-01	0.904
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.488426e-01	0.827
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	7.730322e-02	1.112
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	1.027422e-01	0.988
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	9.260688e-02	1.033
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	1.027422e-01	0.988
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.127874e-01	0.948
DNA strand elongation	R-HSA-69190	1.298973e-01	0.886
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.031960e-01	0.986
Mismatch Repair	R-HSA-5358508	1.132944e-01	0.946
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	8.189978e-02	1.087
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.000503e-01	1.000
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	1.351396e-01	0.869
Neurofascin interactions	R-HSA-447043	7.730322e-02	1.112
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.000503e-01	1.000
TP53 Regulates Metabolic Genes	R-HSA-5628897	1.212613e-01	0.916
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	8.621677e-02	1.064
Signaling by TGFB family members	R-HSA-9006936	1.252785e-01	0.902
Formation of editosomes by ADAR proteins	R-HSA-77042	9.649901e-02	1.015
Inhibition of PKR	R-HSA-169131	9.649901e-02	1.015
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	1.412023e-01	0.850
Manipulation of host energy metabolism	R-HSA-9636667	1.412023e-01	0.850
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	1.412023e-01	0.850
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	1.412023e-01	0.850
Unwinding of DNA	R-HSA-176974	1.247693e-01	0.904
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.388323e-01	0.858
Golgi-to-ER retrograde transport	R-HSA-8856688	1.375365e-01	0.862
Developmental Cell Lineages	R-HSA-9734767	1.362555e-01	0.866
Aquaporin-mediated transport	R-HSA-445717	1.420630e-01	0.848
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	1.097820e-01	0.959
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.087911e-02	1.042
Regulation of TNFR1 signaling	R-HSA-5357905	1.427405e-01	0.845
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	9.155895e-02	1.038
Vesicle-mediated transport	R-HSA-5653656	1.209386e-01	0.917
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.247693e-01	0.904
Transcriptional Regulation by VENTX	R-HSA-8853884	1.000503e-01	1.000
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.195274e-01	0.923
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.505221e-01	0.822
ARMS-mediated activation	R-HSA-170984	1.247693e-01	0.904
Cellular response to mitochondrial stress	R-HSA-9840373	1.247693e-01	0.904
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.354301e-01	0.868
Beta-catenin independent WNT signaling	R-HSA-3858494	9.453668e-02	1.024
TNF signaling	R-HSA-75893	1.104383e-01	0.957
Interleukin-1 family signaling	R-HSA-446652	9.753241e-02	1.011
Oxidative Stress Induced Senescence	R-HSA-2559580	1.257192e-01	0.901
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.151171e-02	1.089
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.378683e-01	0.861
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.082566e-01	0.966
RSV-host interactions	R-HSA-9833110	1.403946e-01	0.853
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.388323e-01	0.858
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.045914e-01	0.981
NRAGE signals death through JNK	R-HSA-193648	1.104383e-01	0.957
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	1.418320e-01	0.848
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.189978e-02	1.087
Signaling by NOTCH1	R-HSA-1980143	1.391617e-01	0.856
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.127874e-01	0.948
Downstream TCR signaling	R-HSA-202424	1.351261e-01	0.869
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.354301e-01	0.868
Uptake and function of diphtheria toxin	R-HSA-5336415	9.239709e-02	1.034
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.082566e-01	0.966
Respiratory syncytial virus genome replication	R-HSA-9834752	1.247693e-01	0.904
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	8.918121e-02	1.050
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.898946e-02	1.004
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.354301e-01	0.868
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.354301e-01	0.868
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.354301e-01	0.868
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.354301e-01	0.868
Ion transport by P-type ATPases	R-HSA-936837	7.727774e-02	1.112
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	9.260688e-02	1.033
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.593972e-02	1.018
Nephrin family interactions	R-HSA-373753	1.355440e-01	0.868
Transcriptional regulation by RUNX2	R-HSA-8878166	8.073993e-02	1.093
Glucagon-type ligand receptors	R-HSA-420092	1.046341e-01	0.980
Signaling by FGFR4	R-HSA-5654743	1.205040e-01	0.919
Interferon alpha/beta signaling	R-HSA-909733	1.256418e-01	0.901
Suppression of phagosomal maturation	R-HSA-9637687	8.189978e-02	1.087
FLT3 Signaling	R-HSA-9607240	1.000503e-01	1.000
Signaling by FGFR3	R-HSA-5654741	1.351396e-01	0.869
Regulation of beta-cell development	R-HSA-186712	1.289478e-01	0.890
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.789402e-02	1.009
Response of Mtb to phagocytosis	R-HSA-9637690	1.205040e-01	0.919
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.104383e-01	0.957
Regulation of gene expression in beta cells	R-HSA-210745	1.046341e-01	0.980
Nuclear events mediated by NFE2L2	R-HSA-9759194	8.729218e-02	1.059
Signaling by CSF3 (G-CSF)	R-HSA-9674555	1.046341e-01	0.980
Interleukin-12 family signaling	R-HSA-447115	1.195846e-01	0.922
Organelle biogenesis and maintenance	R-HSA-1852241	1.505746e-01	0.822
ABC transporter disorders	R-HSA-5619084	1.513069e-01	0.820
PCP/CE pathway	R-HSA-4086400	1.513069e-01	0.820
Eukaryotic Translation Elongation	R-HSA-156842	1.516364e-01	0.819
Cellular response to chemical stress	R-HSA-9711123	1.522247e-01	0.818
Co-inhibition by PD-1	R-HSA-389948	1.526797e-01	0.816
TCF dependent signaling in response to WNT	R-HSA-201681	1.529704e-01	0.815
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.559040e-01	0.807
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.574054e-01	0.803
NOD1/2 Signaling Pathway	R-HSA-168638	1.574054e-01	0.803
GPER1 signaling	R-HSA-9634597	1.584777e-01	0.800
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.584777e-01	0.800
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	1.591424e-01	0.798
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.591424e-01	0.798
Formation of the posterior neural plate	R-HSA-9832991	1.593500e-01	0.798
vRNP Assembly	R-HSA-192905	1.593500e-01	0.798
ChREBP activates metabolic gene expression	R-HSA-163765	1.593500e-01	0.798
MHC class II antigen presentation	R-HSA-2132295	1.636750e-01	0.786
Signaling by MET	R-HSA-6806834	1.639275e-01	0.785
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	1.666009e-01	0.778
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.699474e-01	0.770
tRNA processing	R-HSA-72306	1.699474e-01	0.770
Neddylation	R-HSA-8951664	1.709018e-01	0.767
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	1.713804e-01	0.766
Cellular hexose transport	R-HSA-189200	1.713804e-01	0.766
Eukaryotic Translation Termination	R-HSA-72764	1.750710e-01	0.757
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	1.768361e-01	0.752
RNA Polymerase III Transcription	R-HSA-74158	1.768361e-01	0.752
Signaling by GSK3beta mutants	R-HSA-5339716	1.772366e-01	0.751
Integration of provirus	R-HSA-162592	1.772366e-01	0.751
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.772366e-01	0.751
COPI-mediated anterograde transport	R-HSA-6807878	1.811693e-01	0.742
Meiotic recombination	R-HSA-912446	1.833217e-01	0.737
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	1.836963e-01	0.736
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	1.836963e-01	0.736
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	1.836963e-01	0.736
mRNA Editing: A to I Conversion	R-HSA-75064	1.836963e-01	0.736
Neurophilin interactions with VEGF and VEGFR	R-HSA-194306	1.836963e-01	0.736
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.836963e-01	0.736
C6 deamination of adenosine	R-HSA-75102	1.836963e-01	0.736
Diseases of Cellular Senescence	R-HSA-9630747	1.836963e-01	0.736
Diseases of cellular response to stress	R-HSA-9675132	1.836963e-01	0.736
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	1.836963e-01	0.736
Regulation of PTEN mRNA translation	R-HSA-8943723	1.838757e-01	0.735
Regulated Necrosis	R-HSA-5218859	1.923695e-01	0.716
Regulation of insulin secretion	R-HSA-422356	1.936371e-01	0.713
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.954126e-01	0.709
Disorders of Nervous System Development	R-HSA-9697154	1.954126e-01	0.709
Pervasive developmental disorders	R-HSA-9005895	1.954126e-01	0.709
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.954126e-01	0.709
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.954126e-01	0.709
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.954126e-01	0.709
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.954126e-01	0.709
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.954126e-01	0.709
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.954126e-01	0.709
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	1.954126e-01	0.709
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.954126e-01	0.709
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.966021e-01	0.706
mRNA Splicing - Major Pathway	R-HSA-72163	1.998298e-01	0.699
FOXO-mediated transcription	R-HSA-9614085	2.000015e-01	0.699
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.006274e-01	0.698
ABC-family proteins mediated transport	R-HSA-382556	2.064496e-01	0.685
Transcriptional Regulation by E2F6	R-HSA-8953750	2.073740e-01	0.683
RAS processing	R-HSA-9648002	2.073740e-01	0.683
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.078553e-01	0.682
HDMs demethylate histones	R-HSA-3214842	2.095343e-01	0.679
TGFBR3 expression	R-HSA-9839394	2.095343e-01	0.679
Selenocysteine synthesis	R-HSA-2408557	2.129786e-01	0.672
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.138057e-01	0.670
Formation of axial mesoderm	R-HSA-9796292	2.138057e-01	0.670
Frs2-mediated activation	R-HSA-170968	2.138057e-01	0.670
rRNA processing	R-HSA-72312	2.162347e-01	0.665
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.178742e-01	0.662
HDACs deacetylate histones	R-HSA-3214815	2.184589e-01	0.661
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	2.226471e-01	0.652
trans-Golgi Network Vesicle Budding	R-HSA-199992	2.237648e-01	0.650
Axonal growth stimulation	R-HSA-209563	2.240901e-01	0.650
IRAK4 deficiency (TLR5)	R-HSA-5603037	2.240901e-01	0.650
MET interacts with TNS proteins	R-HSA-8875513	2.240901e-01	0.650
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	2.240901e-01	0.650
Viral mRNA Translation	R-HSA-192823	2.262685e-01	0.645
Signaling by FGFR1	R-HSA-5654736	2.275529e-01	0.643
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.278781e-01	0.642
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.323501e-01	0.634
Interaction between L1 and Ankyrins	R-HSA-445095	2.359164e-01	0.627
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	2.380268e-01	0.623
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	2.380268e-01	0.623
Disease	R-HSA-1643685	2.387365e-01	0.622
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	2.392806e-01	0.621
Translation of Structural Proteins	R-HSA-9683701	2.392806e-01	0.621
Regulation of T cell activation by CD28 family	R-HSA-388841	2.428489e-01	0.615
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.460591e-01	0.609
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	2.493185e-01	0.603
Processive synthesis on the lagging strand	R-HSA-69183	2.509858e-01	0.600
Beta-catenin phosphorylation cascade	R-HSA-196299	2.509858e-01	0.600
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.509858e-01	0.600
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.509858e-01	0.600
DCC mediated attractive signaling	R-HSA-418885	2.509858e-01	0.600
Formation of the anterior neural plate	R-HSA-9823739	2.509858e-01	0.600
mRNA Splicing	R-HSA-72172	2.524231e-01	0.598
Integration of energy metabolism	R-HSA-163685	2.536790e-01	0.596
Extension of Telomeres	R-HSA-180786	2.554559e-01	0.593
Deadenylation-dependent mRNA decay	R-HSA-429914	2.554559e-01	0.593
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.573765e-01	0.589
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.573765e-01	0.589
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.624874e-01	0.581
ATP sensitive Potassium channels	R-HSA-1296025	2.624874e-01	0.581
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.624874e-01	0.581
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.624874e-01	0.581
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.624874e-01	0.581
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	2.624874e-01	0.581
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.624874e-01	0.581
NADE modulates death signalling	R-HSA-205025	2.624874e-01	0.581
Sensory perception of sour taste	R-HSA-9729555	2.624874e-01	0.581
TNFR1-mediated ceramide production	R-HSA-5626978	2.624874e-01	0.581
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.628306e-01	0.580
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.628306e-01	0.580
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.696586e-01	0.569
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	2.696586e-01	0.569
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.696586e-01	0.569
Phosphorylation of the APC/C	R-HSA-176412	2.696586e-01	0.569
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	2.696586e-01	0.569
Prolonged ERK activation events	R-HSA-169893	2.696586e-01	0.569
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.696586e-01	0.569
Unfolded Protein Response (UPR)	R-HSA-381119	2.722115e-01	0.565
RMTs methylate histone arginines	R-HSA-3214858	2.722193e-01	0.565
Netrin-1 signaling	R-HSA-373752	2.722193e-01	0.565
RNA Polymerase I Transcription	R-HSA-73864	2.736227e-01	0.563
MAP kinase activation	R-HSA-450294	2.744987e-01	0.561
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	2.764307e-01	0.558
Activation of the pre-replicative complex	R-HSA-68962	2.764307e-01	0.558
RNA Polymerase III Transcription Initiation	R-HSA-76046	2.764307e-01	0.558
Interleukin-37 signaling	R-HSA-9008059	2.764307e-01	0.558
TCR signaling	R-HSA-202403	2.820974e-01	0.550
Somitogenesis	R-HSA-9824272	2.833714e-01	0.548
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.833714e-01	0.548
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	2.847911e-01	0.545
Cellular response to starvation	R-HSA-9711097	2.849923e-01	0.545
Disorders of transmembrane transporters	R-HSA-5619115	2.854509e-01	0.544
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.883192e-01	0.540
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.883192e-01	0.540
Synthesis of PG	R-HSA-1483148	2.883192e-01	0.540
Trafficking of AMPA receptors	R-HSA-399719	2.900976e-01	0.537
Signaling by FGFR2	R-HSA-5654738	2.908111e-01	0.536
Interferon gamma signaling	R-HSA-877300	2.910027e-01	0.536
Immune System	R-HSA-168256	2.937177e-01	0.532
Regulation of pyruvate metabolism	R-HSA-9861718	2.945901e-01	0.531
Infectious disease	R-HSA-5663205	2.955055e-01	0.529
Defective F9 activation	R-HSA-9673221	2.989867e-01	0.524
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	2.989867e-01	0.524
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.989867e-01	0.524
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	2.989867e-01	0.524
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	2.989867e-01	0.524
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	2.989867e-01	0.524
NrCAM interactions	R-HSA-447038	2.989867e-01	0.524
Amyloid fiber formation	R-HSA-977225	2.994881e-01	0.524
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	3.035717e-01	0.518
Inwardly rectifying K+ channels	R-HSA-1296065	3.038109e-01	0.517
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	3.038109e-01	0.517
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	3.038109e-01	0.517
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	3.058639e-01	0.514
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.069231e-01	0.513
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.069231e-01	0.513
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	3.069231e-01	0.513
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.069231e-01	0.513
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.069231e-01	0.513
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	3.069231e-01	0.513
Specification of primordial germ cells	R-HSA-9827857	3.069231e-01	0.513
Signaling by Nuclear Receptors	R-HSA-9006931	3.074930e-01	0.512
Telomere Maintenance	R-HSA-157579	3.104666e-01	0.508
Neutrophil degranulation	R-HSA-6798695	3.125168e-01	0.505
NGF-stimulated transcription	R-HSA-9031628	3.171816e-01	0.499
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.175513e-01	0.498
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.175513e-01	0.498
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.175513e-01	0.498
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.184648e-01	0.497
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.184648e-01	0.497
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.184648e-01	0.497
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.254303e-01	0.488
RNA Polymerase III Transcription Termination	R-HSA-73980	3.254303e-01	0.488
G beta:gamma signalling through PLC beta	R-HSA-418217	3.254303e-01	0.488
Polo-like kinase mediated events	R-HSA-156711	3.254303e-01	0.488
GAB1 signalosome	R-HSA-180292	3.254303e-01	0.488
Ephrin signaling	R-HSA-3928664	3.254303e-01	0.488
Presynaptic function of Kainate receptors	R-HSA-500657	3.254303e-01	0.488
Nephron development	R-HSA-9831926	3.254303e-01	0.488
HATs acetylate histones	R-HSA-3214847	3.264982e-01	0.486
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.313001e-01	0.480
Cardiac conduction	R-HSA-5576891	3.319554e-01	0.479
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	3.336818e-01	0.477
Noncanonical activation of NOTCH3	R-HSA-9017802	3.336818e-01	0.477
Cam-PDE 1 activation	R-HSA-111957	3.336818e-01	0.477
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	3.336818e-01	0.477
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	3.336818e-01	0.477
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.336818e-01	0.477
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	3.336818e-01	0.477
Signalling to p38 via RIT and RIN	R-HSA-187706	3.336818e-01	0.477
VEGF binds to VEGFR leading to receptor dimerization	R-HSA-195399	3.336818e-01	0.477
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.336818e-01	0.477
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	3.336818e-01	0.477
VEGF ligand-receptor interactions	R-HSA-194313	3.336818e-01	0.477
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.365523e-01	0.473
Circadian clock	R-HSA-9909396	3.389437e-01	0.470
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.429740e-01	0.465
Germ layer formation at gastrulation	R-HSA-9754189	3.438050e-01	0.464
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	3.438050e-01	0.464
O2/CO2 exchange in erythrocytes	R-HSA-1480926	3.438050e-01	0.464
Rap1 signalling	R-HSA-392517	3.438050e-01	0.464
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	3.450397e-01	0.462
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	3.450397e-01	0.462
Translation	R-HSA-72766	3.507396e-01	0.455
Signaling by WNT	R-HSA-195721	3.524007e-01	0.453
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	3.528908e-01	0.452
PERK regulates gene expression	R-HSA-381042	3.587534e-01	0.445
Signaling by NODAL	R-HSA-1181150	3.620148e-01	0.441
Common Pathway of Fibrin Clot Formation	R-HSA-140875	3.620148e-01	0.441
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	3.626774e-01	0.440
Interleukin-17 signaling	R-HSA-448424	3.628203e-01	0.440
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.666618e-01	0.436
Signaling by LTK in cancer	R-HSA-9842640	3.666618e-01	0.436
Autointegration results in viral DNA circles	R-HSA-177539	3.666618e-01	0.436
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.666618e-01	0.436
Integration of viral DNA into host genomic DNA	R-HSA-175567	3.666618e-01	0.436
NADPH regeneration	R-HSA-389542	3.666618e-01	0.436
HDL clearance	R-HSA-8964011	3.666618e-01	0.436
Ion channel transport	R-HSA-983712	3.671969e-01	0.435
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	3.724251e-01	0.429
RUNX2 regulates bone development	R-HSA-8941326	3.724251e-01	0.429
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.740568e-01	0.427
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.764223e-01	0.424
MyD88 deficiency (TLR2/4)	R-HSA-5602498	3.800313e-01	0.420
G-protein activation	R-HSA-202040	3.800313e-01	0.420
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	3.800313e-01	0.420
Lagging Strand Synthesis	R-HSA-69186	3.800313e-01	0.420
Transmission across Chemical Synapses	R-HSA-112315	3.814067e-01	0.419
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.833962e-01	0.416
Ca2+ pathway	R-HSA-4086398	3.926196e-01	0.406
Diseases of carbohydrate metabolism	R-HSA-5663084	3.926196e-01	0.406
HCMV Late Events	R-HSA-9610379	3.965360e-01	0.402
G alpha (z) signalling events	R-HSA-418597	3.967556e-01	0.401
Serine metabolism	R-HSA-977347	3.978289e-01	0.400
RUNX3 regulates WNT signaling	R-HSA-8951430	3.980112e-01	0.400
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.980112e-01	0.400
IFNG signaling activates MAPKs	R-HSA-9732724	3.980112e-01	0.400
PTK6 Expression	R-HSA-8849473	3.980112e-01	0.400
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	3.980112e-01	0.400
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	3.980112e-01	0.400
NOSTRIN mediated eNOS trafficking	R-HSA-203641	3.980112e-01	0.400
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.980112e-01	0.400
Cation-coupled Chloride cotransporters	R-HSA-426117	3.980112e-01	0.400
CHL1 interactions	R-HSA-447041	3.980112e-01	0.400
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.980112e-01	0.400
Signaling by ERBB4	R-HSA-1236394	4.025353e-01	0.395
Leishmania phagocytosis	R-HSA-9664417	4.026171e-01	0.395
FCGR3A-mediated phagocytosis	R-HSA-9664422	4.026171e-01	0.395
Parasite infection	R-HSA-9664407	4.026171e-01	0.395
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.032535e-01	0.394
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	4.079306e-01	0.389
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	4.080572e-01	0.389
Protein ubiquitination	R-HSA-8852135	4.124321e-01	0.385
Iron uptake and transport	R-HSA-917937	4.124321e-01	0.385
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	4.130434e-01	0.384
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	4.148228e-01	0.382
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	4.153852e-01	0.382
MyD88 dependent cascade initiated on endosome	R-HSA-975155	4.161023e-01	0.381
RNA Polymerase I Promoter Clearance	R-HSA-73854	4.223042e-01	0.374
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	4.242650e-01	0.372
MyD88-independent TLR4 cascade	R-HSA-166166	4.242650e-01	0.372
Inhibition of DNA recombination at telomere	R-HSA-9670095	4.264063e-01	0.370
Diseases of Immune System	R-HSA-5260271	4.264063e-01	0.370
Diseases associated with the TLR signaling cascade	R-HSA-5602358	4.264063e-01	0.370
Type I hemidesmosome assembly	R-HSA-446107	4.278107e-01	0.369
EGFR interacts with phospholipase C-gamma	R-HSA-212718	4.278107e-01	0.369
Regulation of NPAS4 mRNA translation	R-HSA-9768778	4.278107e-01	0.369
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.278107e-01	0.369
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	4.278107e-01	0.369
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	4.278107e-01	0.369
ROBO receptors bind AKAP5	R-HSA-9010642	4.278107e-01	0.369
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	4.326806e-01	0.364
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	4.326806e-01	0.364
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	4.326806e-01	0.364
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.396608e-01	0.357
Peroxisomal protein import	R-HSA-9033241	4.416728e-01	0.355
Integrin cell surface interactions	R-HSA-216083	4.419523e-01	0.355
Selenoamino acid metabolism	R-HSA-2408522	4.435565e-01	0.353
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.486667e-01	0.348
Thromboxane signalling through TP receptor	R-HSA-428930	4.496979e-01	0.347
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	4.496979e-01	0.347
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	4.496979e-01	0.347
Sensory processing of sound	R-HSA-9659379	4.517176e-01	0.345
MASTL Facilitates Mitotic Progression	R-HSA-2465910	4.561368e-01	0.341
Calcineurin activates NFAT	R-HSA-2025928	4.561368e-01	0.341
p75NTR regulates axonogenesis	R-HSA-193697	4.561368e-01	0.341
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.561368e-01	0.341
mRNA Editing	R-HSA-75072	4.561368e-01	0.341
AKT phosphorylates targets in the nucleus	R-HSA-198693	4.561368e-01	0.341
Regulation of CDH11 gene transcription	R-HSA-9762293	4.561368e-01	0.341
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.561368e-01	0.341
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	4.561368e-01	0.341
ER to Golgi Anterograde Transport	R-HSA-199977	4.594171e-01	0.338
Parasitic Infection Pathways	R-HSA-9824443	4.599594e-01	0.337
Leishmania infection	R-HSA-9658195	4.599594e-01	0.337
Formation of paraxial mesoderm	R-HSA-9793380	4.637667e-01	0.334
Activation of GABAB receptors	R-HSA-991365	4.658024e-01	0.332
GABA B receptor activation	R-HSA-977444	4.658024e-01	0.332
RNA Polymerase I Transcription Initiation	R-HSA-73762	4.658024e-01	0.332
Activation of G protein gated Potassium channels	R-HSA-1296041	4.664221e-01	0.331
G protein gated Potassium channels	R-HSA-1296059	4.664221e-01	0.331
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	4.664221e-01	0.331
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.664221e-01	0.331
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.664221e-01	0.331
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	4.664221e-01	0.331
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	4.728723e-01	0.325
Gastrulation	R-HSA-9758941	4.735038e-01	0.325
Heme signaling	R-HSA-9707616	4.746981e-01	0.324
Signaling by FGFR	R-HSA-190236	4.765600e-01	0.322
Signaling by FLT3 fusion proteins	R-HSA-9703465	4.828408e-01	0.316
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.828408e-01	0.316
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	4.828408e-01	0.316
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	4.828408e-01	0.316
Binding and entry of HIV virion	R-HSA-173107	4.830623e-01	0.316
EGFR Transactivation by Gastrin	R-HSA-2179392	4.830623e-01	0.316
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	4.830623e-01	0.316
MET activates RAP1 and RAC1	R-HSA-8875555	4.830623e-01	0.316
Defective factor IX causes hemophilia B	R-HSA-9668250	4.830623e-01	0.316
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.830623e-01	0.316
Class I MHC mediated antigen processing & presentation	R-HSA-983169	4.855520e-01	0.314
Proteasome assembly	R-HSA-9907900	4.913908e-01	0.309
Toll-like Receptor Cascades	R-HSA-168898	4.988130e-01	0.302
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	4.989431e-01	0.302
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	4.989431e-01	0.302
RNA Polymerase I Transcription Termination	R-HSA-73863	4.989431e-01	0.302
Signaling by BMP	R-HSA-201451	4.989431e-01	0.302
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.989431e-01	0.302
Extra-nuclear estrogen signaling	R-HSA-9009391	5.024629e-01	0.299
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.039566e-01	0.298
Signaling by APC mutants	R-HSA-4839744	5.086563e-01	0.294
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	5.086563e-01	0.294
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	5.086563e-01	0.294
Presynaptic depolarization and calcium channel opening	R-HSA-112308	5.086563e-01	0.294
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	5.086563e-01	0.294
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	5.086563e-01	0.294
PECAM1 interactions	R-HSA-210990	5.086563e-01	0.294
CD163 mediating an anti-inflammatory response	R-HSA-9662834	5.086563e-01	0.294
Protein-protein interactions at synapses	R-HSA-6794362	5.091798e-01	0.293
Neuronal System	R-HSA-112316	5.124273e-01	0.290
Telomere Extension By Telomerase	R-HSA-171319	5.147201e-01	0.288
HIV elongation arrest and recovery	R-HSA-167287	5.147201e-01	0.288
Pausing and recovery of HIV elongation	R-HSA-167290	5.147201e-01	0.288
Activation of kainate receptors upon glutamate binding	R-HSA-451326	5.147201e-01	0.288
Condensation of Prophase Chromosomes	R-HSA-2299718	5.163604e-01	0.287
mRNA Splicing - Minor Pathway	R-HSA-72165	5.163604e-01	0.287
Signaling by TGFBR3	R-HSA-9839373	5.163604e-01	0.287
DARPP-32 events	R-HSA-180024	5.301647e-01	0.276
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	5.329846e-01	0.273
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.329846e-01	0.273
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.329846e-01	0.273
Signaling by AMER1 mutants	R-HSA-4839748	5.329846e-01	0.273
Signaling by AXIN mutants	R-HSA-4839735	5.329846e-01	0.273
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.329846e-01	0.273
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.329846e-01	0.273
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	5.362594e-01	0.271
Activation of HOX genes during differentiation	R-HSA-5619507	5.362594e-01	0.271
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	5.368403e-01	0.270
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	5.382982e-01	0.269
Gluconeogenesis	R-HSA-70263	5.406565e-01	0.267
Maternal to zygotic transition (MZT)	R-HSA-9816359	5.435447e-01	0.265
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.452709e-01	0.263
Scavenging by Class F Receptors	R-HSA-3000484	5.561097e-01	0.255
Repression of WNT target genes	R-HSA-4641265	5.561097e-01	0.255
GRB2 events in EGFR signaling	R-HSA-179812	5.561097e-01	0.255
Regulation of IFNG signaling	R-HSA-877312	5.561097e-01	0.255
Trafficking and processing of endosomal TLR	R-HSA-1679131	5.561097e-01	0.255
Leading Strand Synthesis	R-HSA-69109	5.561097e-01	0.255
Polymerase switching	R-HSA-69091	5.561097e-01	0.255
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.561097e-01	0.255
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	5.586221e-01	0.253
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	5.662312e-01	0.247
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	5.662312e-01	0.247
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	5.662312e-01	0.247
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	5.682217e-01	0.245
NoRC negatively regulates rRNA expression	R-HSA-427413	5.686010e-01	0.245
Signaling by WNT in cancer	R-HSA-4791275	5.744525e-01	0.241
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	5.780910e-01	0.238
Adenylate cyclase activating pathway	R-HSA-170660	5.780910e-01	0.238
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.780910e-01	0.238
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	5.780910e-01	0.238
Processing of SMDT1	R-HSA-8949664	5.780910e-01	0.238
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.780910e-01	0.238
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	5.780910e-01	0.238
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.780910e-01	0.238
Platelet Adhesion to exposed collagen	R-HSA-75892	5.780910e-01	0.238
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	5.784534e-01	0.238
Platelet degranulation	R-HSA-114608	5.810641e-01	0.236
IRE1alpha activates chaperones	R-HSA-381070	5.816488e-01	0.235
RNA Polymerase I Promoter Escape	R-HSA-73772	5.870592e-01	0.231
Formation of RNA Pol II elongation complex	R-HSA-112382	5.870592e-01	0.231
Neurexins and neuroligins	R-HSA-6794361	5.870592e-01	0.231
Integrin signaling	R-HSA-354192	5.885227e-01	0.230
Nuclear RNA decay	R-HSA-9930044	5.885227e-01	0.230
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	5.885227e-01	0.230
SLC transporter disorders	R-HSA-5619102	5.950339e-01	0.225
RNA Polymerase II Pre-transcription Events	R-HSA-674695	5.977668e-01	0.223
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.981802e-01	0.223
Removal of the Flap Intermediate	R-HSA-69166	5.989851e-01	0.223
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.989851e-01	0.223
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.989851e-01	0.223
Regulation of KIT signaling	R-HSA-1433559	5.989851e-01	0.223
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	5.989851e-01	0.223
Zinc transporters	R-HSA-435354	5.989851e-01	0.223
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	6.091033e-01	0.215
Signal amplification	R-HSA-392518	6.156172e-01	0.211
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	6.156172e-01	0.211
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	6.156172e-01	0.211
SHC1 events in EGFR signaling	R-HSA-180336	6.188457e-01	0.208
RNA Polymerase III Chain Elongation	R-HSA-73780	6.188457e-01	0.208
ERBB2 Regulates Cell Motility	R-HSA-6785631	6.188457e-01	0.208
Adenylate cyclase inhibitory pathway	R-HSA-170670	6.188457e-01	0.208
Telomere C-strand synthesis initiation	R-HSA-174430	6.188457e-01	0.208
Signaling by Activin	R-HSA-1502540	6.188457e-01	0.208
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	6.188457e-01	0.208
Lysosphingolipid and LPA receptors	R-HSA-419408	6.188457e-01	0.208
Translation of Structural Proteins	R-HSA-9694635	6.257206e-01	0.204
C-type lectin receptors (CLRs)	R-HSA-5621481	6.263756e-01	0.203
Signalling to ERKs	R-HSA-187687	6.286425e-01	0.202
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	6.286425e-01	0.202
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.309310e-01	0.200
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	6.315037e-01	0.200
Nuclear Receptor transcription pathway	R-HSA-383280	6.347593e-01	0.197
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	6.377238e-01	0.195
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	6.377238e-01	0.195
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.377238e-01	0.195
Activation of SMO	R-HSA-5635838	6.377238e-01	0.195
PRC2 methylates histones and DNA	R-HSA-212300	6.413216e-01	0.193
G1/S-Specific Transcription	R-HSA-69205	6.413216e-01	0.193
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	6.524084e-01	0.185
TRAF6 mediated IRF7 activation	R-HSA-933541	6.536570e-01	0.185
NCAM1 interactions	R-HSA-419037	6.536570e-01	0.185
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	6.556680e-01	0.183
Phase 2 - plateau phase	R-HSA-5576893	6.556680e-01	0.183
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.556680e-01	0.183
Heme assimilation	R-HSA-9927020	6.556680e-01	0.183
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.556680e-01	0.183
Passive transport by Aquaporins	R-HSA-432047	6.556680e-01	0.183
Galactose catabolism	R-HSA-70370	6.556680e-01	0.183
tRNA modification in the mitochondrion	R-HSA-6787450	6.556680e-01	0.183
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	6.556680e-01	0.183
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	6.656515e-01	0.177
MET promotes cell motility	R-HSA-8875878	6.656515e-01	0.177
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	6.656515e-01	0.177
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.656515e-01	0.177
GABA receptor activation	R-HSA-977443	6.703930e-01	0.174
Sphingolipid de novo biosynthesis	R-HSA-1660661	6.703930e-01	0.174
Metabolism of polyamines	R-HSA-351202	6.703930e-01	0.174
PI3K events in ERBB2 signaling	R-HSA-1963642	6.727244e-01	0.172
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.727244e-01	0.172
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.727244e-01	0.172
Regulation of NPAS4 gene expression	R-HSA-9768759	6.727244e-01	0.172
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	6.773087e-01	0.169
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.773087e-01	0.169
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.773087e-01	0.169
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	6.773087e-01	0.169
PI Metabolism	R-HSA-1483255	6.785298e-01	0.168
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	6.886325e-01	0.162
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	6.886325e-01	0.162
HIV Transcription Elongation	R-HSA-167169	6.886325e-01	0.162
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.886325e-01	0.162
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.886325e-01	0.162
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.889369e-01	0.162
PKA activation	R-HSA-163615	6.889369e-01	0.162
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.889369e-01	0.162
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.889369e-01	0.162
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.889369e-01	0.162
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	6.889369e-01	0.162
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.889369e-01	0.162
NCAM signaling for neurite out-growth	R-HSA-375165	6.891866e-01	0.162
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.018616e-01	0.154
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	7.043472e-01	0.152
Specification of the neural plate border	R-HSA-9834899	7.043472e-01	0.152
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	7.043472e-01	0.152
The NLRP3 inflammasome	R-HSA-844456	7.043472e-01	0.152
Diseases of hemostasis	R-HSA-9671793	7.043472e-01	0.152
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	7.043472e-01	0.152
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	7.095895e-01	0.149
XBP1(S) activates chaperone genes	R-HSA-381038	7.095895e-01	0.149
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	7.102980e-01	0.149
Intra-Golgi traffic	R-HSA-6811438	7.102980e-01	0.149
FCERI mediated NF-kB activation	R-HSA-2871837	7.139553e-01	0.146
Platelet homeostasis	R-HSA-418346	7.141597e-01	0.146
Pyruvate metabolism	R-HSA-70268	7.171703e-01	0.144
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.189950e-01	0.143
Co-inhibition by CTLA4	R-HSA-389513	7.189950e-01	0.143
VxPx cargo-targeting to cilium	R-HSA-5620916	7.189950e-01	0.143
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.189950e-01	0.143
Signal transduction by L1	R-HSA-445144	7.189950e-01	0.143
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.206497e-01	0.142
Cytosolic tRNA aminoacylation	R-HSA-379716	7.206497e-01	0.142
Cleavage of the damaged pyrimidine	R-HSA-110329	7.206497e-01	0.142
Depyrimidination	R-HSA-73928	7.206497e-01	0.142
tRNA modification in the nucleus and cytosol	R-HSA-6782315	7.243342e-01	0.140
Stimuli-sensing channels	R-HSA-2672351	7.276042e-01	0.138
Platelet activation, signaling and aggregation	R-HSA-76002	7.276653e-01	0.138
Defective pyroptosis	R-HSA-9710421	7.306877e-01	0.136
TBC/RABGAPs	R-HSA-8854214	7.306877e-01	0.136
Signaling by NTRK1 (TRKA)	R-HSA-187037	7.318857e-01	0.136
Kidney development	R-HSA-9830369	7.326196e-01	0.135
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.329179e-01	0.135
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.329179e-01	0.135
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	7.329179e-01	0.135
Zygotic genome activation (ZGA)	R-HSA-9819196	7.329179e-01	0.135
Vitamin C (ascorbate) metabolism	R-HSA-196836	7.329179e-01	0.135
Base Excision Repair	R-HSA-73884	7.390348e-01	0.131
Class B/2 (Secretin family receptors)	R-HSA-373080	7.390348e-01	0.131
Transcription of the HIV genome	R-HSA-167172	7.407075e-01	0.130
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.461518e-01	0.127
Mitochondrial calcium ion transport	R-HSA-8949215	7.461518e-01	0.127
Hemostasis	R-HSA-109582	7.532401e-01	0.123
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	7.571628e-01	0.121
Leishmania parasite growth and survival	R-HSA-9664433	7.571628e-01	0.121
FGFR2 alternative splicing	R-HSA-6803529	7.587307e-01	0.120
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.587307e-01	0.120
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.587307e-01	0.120
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.587307e-01	0.120
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.587307e-01	0.120
Signaling by KIT in disease	R-HSA-9669938	7.587307e-01	0.120
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.587307e-01	0.120
Late SARS-CoV-2 Infection Events	R-HSA-9772573	7.595958e-01	0.119
Protein localization	R-HSA-9609507	7.635223e-01	0.117
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.678193e-01	0.115
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	7.704071e-01	0.113
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.706870e-01	0.113
Carnitine shuttle	R-HSA-200425	7.706870e-01	0.113
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.706870e-01	0.113
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.706870e-01	0.113
Interleukin receptor SHC signaling	R-HSA-912526	7.706870e-01	0.113
Syndecan interactions	R-HSA-3000170	7.706870e-01	0.113
G alpha (q) signalling events	R-HSA-416476	7.752764e-01	0.111
Co-stimulation by CD28	R-HSA-389356	7.763776e-01	0.110
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.820514e-01	0.107
Complex III assembly	R-HSA-9865881	7.820514e-01	0.107
Chemokine receptors bind chemokines	R-HSA-380108	7.846586e-01	0.105
Transport to the Golgi and subsequent modification	R-HSA-948021	7.882054e-01	0.103
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	7.924298e-01	0.101
Acyl chain remodelling of PS	R-HSA-1482801	7.928534e-01	0.101
Hyaluronan degradation	R-HSA-2160916	7.928534e-01	0.101
Formation of the nephric duct	R-HSA-9830364	7.928534e-01	0.101
Interleukin-7 signaling	R-HSA-1266695	7.928534e-01	0.101
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.928534e-01	0.101
Laminin interactions	R-HSA-3000157	7.928534e-01	0.101
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.928534e-01	0.101
Rab regulation of trafficking	R-HSA-9007101	7.933820e-01	0.101
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.986926e-01	0.098
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.031206e-01	0.095
TRP channels	R-HSA-3295583	8.031206e-01	0.095
Uptake and actions of bacterial toxins	R-HSA-5339562	8.079031e-01	0.093
Packaging Of Telomere Ends	R-HSA-171306	8.128794e-01	0.090
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.128794e-01	0.090
RNA Polymerase I Promoter Opening	R-HSA-73728	8.128794e-01	0.090
Cristae formation	R-HSA-8949613	8.128794e-01	0.090
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.128794e-01	0.090
Insulin processing	R-HSA-264876	8.128794e-01	0.090
Infection with Mycobacterium tuberculosis	R-HSA-9635486	8.139807e-01	0.089
G alpha (i) signalling events	R-HSA-418594	8.192219e-01	0.087
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.221321e-01	0.085
Formation of the Early Elongation Complex	R-HSA-113418	8.221552e-01	0.085
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	8.221552e-01	0.085
Inflammasomes	R-HSA-622312	8.221552e-01	0.085
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.221552e-01	0.085
Pyroptosis	R-HSA-5620971	8.221552e-01	0.085
DNA methylation	R-HSA-5334118	8.309716e-01	0.080
mRNA Capping	R-HSA-72086	8.309716e-01	0.080
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	8.309716e-01	0.080
Platelet calcium homeostasis	R-HSA-418360	8.309716e-01	0.080
DAP12 signaling	R-HSA-2424491	8.393515e-01	0.076
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.393515e-01	0.076
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.393515e-01	0.076
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.393515e-01	0.076
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.393515e-01	0.076
Cytoprotection by HMOX1	R-HSA-9707564	8.399372e-01	0.076
Synthesis of PA	R-HSA-1483166	8.417043e-01	0.075
Signaling by NTRKs	R-HSA-166520	8.458267e-01	0.073
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.473165e-01	0.072
Cargo concentration in the ER	R-HSA-5694530	8.473165e-01	0.072
Amino acid transport across the plasma membrane	R-HSA-352230	8.536459e-01	0.069
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.536459e-01	0.069
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.548869e-01	0.068
tRNA Aminoacylation	R-HSA-379724	8.593035e-01	0.066
Adaptive Immune System	R-HSA-1280218	8.594623e-01	0.066
FGFR1 mutant receptor activation	R-HSA-1839124	8.620825e-01	0.064
Assembly of the ORC complex at the origin of replication	R-HSA-68616	8.620825e-01	0.064
Cardiogenesis	R-HSA-9733709	8.620825e-01	0.064
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	8.620825e-01	0.064
Adipogenesis	R-HSA-9843745	8.660352e-01	0.062
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.689217e-01	0.061
Effects of PIP2 hydrolysis	R-HSA-114508	8.689217e-01	0.061
Acyl chain remodelling of PC	R-HSA-1482788	8.689217e-01	0.061
Heme degradation	R-HSA-189483	8.689217e-01	0.061
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.689217e-01	0.061
Mitochondrial protein import	R-HSA-1268020	8.700224e-01	0.060
Transcriptional regulation of granulopoiesis	R-HSA-9616222	8.700224e-01	0.060
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.700224e-01	0.060
Signaling by PDGF	R-HSA-186797	8.700224e-01	0.060
NPAS4 regulates expression of target genes	R-HSA-9768919	8.754221e-01	0.058
eNOS activation	R-HSA-203615	8.754221e-01	0.058
Hyaluronan metabolism	R-HSA-2142845	8.754221e-01	0.058
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.754221e-01	0.058
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	8.754221e-01	0.058
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.754221e-01	0.058
Acyl chain remodelling of PE	R-HSA-1482839	8.816005e-01	0.055
RET signaling	R-HSA-8853659	8.874729e-01	0.052
Glycosphingolipid transport	R-HSA-9845576	8.874729e-01	0.052
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.930543e-01	0.049
Cleavage of the damaged purine	R-HSA-110331	8.930543e-01	0.049
Collagen chain trimerization	R-HSA-8948216	8.930543e-01	0.049
SLC-mediated transport of amino acids	R-HSA-9958863	8.936144e-01	0.049
Mitochondrial protein degradation	R-HSA-9837999	8.975422e-01	0.047
Depurination	R-HSA-73927	8.983593e-01	0.047
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.034014e-01	0.044
Pentose phosphate pathway	R-HSA-71336	9.034014e-01	0.044
Extracellular matrix organization	R-HSA-1474244	9.035439e-01	0.044
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.057925e-01	0.043
Glycosphingolipid catabolism	R-HSA-9840310	9.057925e-01	0.043
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.078550e-01	0.042
Potassium Channels	R-HSA-1296071	9.078550e-01	0.042
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.081936e-01	0.042
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.081936e-01	0.042
Interleukin-2 family signaling	R-HSA-451927	9.081936e-01	0.042
Metabolism of cofactors	R-HSA-8978934	9.095536e-01	0.041
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.127484e-01	0.040
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.127484e-01	0.040
Post-translational protein phosphorylation	R-HSA-8957275	9.141982e-01	0.039
HIV Transcription Initiation	R-HSA-167161	9.170775e-01	0.038
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.170775e-01	0.038
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.170775e-01	0.038
Signaling by FGFR1 in disease	R-HSA-5655302	9.170775e-01	0.038
Scavenging by Class A Receptors	R-HSA-3000480	9.170775e-01	0.038
G alpha (s) signalling events	R-HSA-418555	9.192380e-01	0.037
Innate Immune System	R-HSA-168249	9.201236e-01	0.036
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.211920e-01	0.036
RNA Polymerase II Promoter Escape	R-HSA-73776	9.251026e-01	0.034
Signaling by SCF-KIT	R-HSA-1433557	9.251026e-01	0.034
DAP12 interactions	R-HSA-2172127	9.288194e-01	0.032
Interleukin-10 signaling	R-HSA-6783783	9.321899e-01	0.030
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.323520e-01	0.030
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.357094e-01	0.029
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.357094e-01	0.029
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.358676e-01	0.029
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.401502e-01	0.027
Metal ion SLC transporters	R-HSA-425410	9.419332e-01	0.026
Peptide ligand-binding receptors	R-HSA-375276	9.476996e-01	0.023
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.526334e-01	0.021
Amino acids regulate mTORC1	R-HSA-9639288	9.549853e-01	0.020
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.557110e-01	0.020
Role of phospholipids in phagocytosis	R-HSA-2029485	9.589290e-01	0.018
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.613638e-01	0.017
Mitochondrial biogenesis	R-HSA-1592230	9.619267e-01	0.017
Pre-NOTCH Transcription and Translation	R-HSA-1912408	9.623812e-01	0.017
Asparagine N-linked glycosylation	R-HSA-446203	9.629400e-01	0.016
GPCR downstream signalling	R-HSA-388396	9.647166e-01	0.016
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.651063e-01	0.015
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.651063e-01	0.015
Sialic acid metabolism	R-HSA-4085001	9.668395e-01	0.015
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.669089e-01	0.015
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.682981e-01	0.014
Collagen formation	R-HSA-1474290	9.682981e-01	0.014
RAB geranylgeranylation	R-HSA-8873719	9.684867e-01	0.014
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.697320e-01	0.013
Collagen degradation	R-HSA-1442490	9.700522e-01	0.013
Complex I biogenesis	R-HSA-6799198	9.729539e-01	0.012
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.729539e-01	0.012
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.740670e-01	0.011
Post-translational protein modification	R-HSA-597592	9.750215e-01	0.011
Synthesis of bile acids and bile salts	R-HSA-192105	9.755250e-01	0.011
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.790382e-01	0.009
COPII-mediated vesicle transport	R-HSA-204005	9.810701e-01	0.008
ECM proteoglycans	R-HSA-3000178	9.820111e-01	0.008
Metal ion assimilation from the host	R-HSA-9638482	9.820111e-01	0.008
Metabolism of porphyrins	R-HSA-189445	9.820111e-01	0.008
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.829053e-01	0.007
Purine catabolism	R-HSA-74259	9.829053e-01	0.007
Transport of small molecules	R-HSA-382551	9.845396e-01	0.007
Signaling by FGFR in disease	R-HSA-1226099	9.845627e-01	0.007
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.853303e-01	0.006
Citric acid cycle (TCA cycle)	R-HSA-71403	9.853303e-01	0.006
Bile acid and bile salt metabolism	R-HSA-194068	9.855076e-01	0.006
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.867528e-01	0.006
Sphingolipid metabolism	R-HSA-428157	9.869092e-01	0.006
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.873029e-01	0.006
SLC-mediated transport of organic anions	R-HSA-9955298	9.874116e-01	0.006
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.880376e-01	0.005
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.893631e-01	0.005
Peptide hormone metabolism	R-HSA-2980736	9.902671e-01	0.004
Phospholipid metabolism	R-HSA-1483257	9.904166e-01	0.004
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.911331e-01	0.004
Glycosphingolipid metabolism	R-HSA-1660662	9.925520e-01	0.003
Signaling by GPCR	R-HSA-372790	9.926263e-01	0.003
PPARA activates gene expression	R-HSA-1989781	9.927676e-01	0.003
Formation of the cornified envelope	R-HSA-6809371	9.928779e-01	0.003
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.933363e-01	0.003
Neurotransmitter release cycle	R-HSA-112310	9.935156e-01	0.003
Nucleotide catabolism	R-HSA-8956319	9.945599e-01	0.002
FCGR activation	R-HSA-2029481	9.947134e-01	0.002
Degradation of the extracellular matrix	R-HSA-1474228	9.954579e-01	0.002
Scavenging of heme from plasma	R-HSA-2168880	9.954643e-01	0.002
Mitochondrial translation elongation	R-HSA-5389840	9.956902e-01	0.002
Mitochondrial translation initiation	R-HSA-5368286	9.961087e-01	0.002
Metabolism of proteins	R-HSA-392499	9.964574e-01	0.002
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.969859e-01	0.001
Mitochondrial translation termination	R-HSA-5419276	9.978924e-01	0.001
Antimicrobial peptides	R-HSA-6803157	9.980973e-01	0.001
Bacterial Infection Pathways	R-HSA-9824439	9.989078e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.990796e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.991361e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.994427e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.994427e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.996301e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.997711e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.997915e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.998006e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.998159e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.998673e-01	0.000
Keratinization	R-HSA-6805567	9.998780e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.998973e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999571e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999685e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999802e-01	0.000
Infection with Enterobacteria	R-HSA-9640148	9.999881e-01	0.000
GPCR ligand binding	R-HSA-500792	9.999912e-01	0.000
Diseases of metabolism	R-HSA-5668914	9.999930e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999961e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999970e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999972e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999994e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999998e-01	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000