CLK3

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O00488	S93	Sugiyama	ZNF593 ZT86	STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O43823	S124	Sugiyama	AKAP8 AKAP95	SKEGGRGGsGGGGEGIQDREssFRFQPFESYDSRPCLPEHN
O43852	T65	Sugiyama	CALU	FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60292	S158	Sugiyama	SIPA1L3 KIAA0545 SPAL3	FHRLSRRRsKDVEFQDGWPRsPGRAFLPLRHRsssEItLSE
O60343	S588	Sugiyama	TBC1D4 AS160 KIAA0603	tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04264	S21	Sugiyama	KRT1 KRTA	MSRQFSSRSGYRSGGGFSSGsAGIINYQRRTTSSSTRRSGG
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P07237	S449	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	ANEVEAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKF
P08195	S607	Sugiyama	SLC3A2 MDU1	ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P13639	S584	Sugiyama	EEF2 EF2	DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625	S64	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P15311	S539	Sugiyama	EZR VIL2	TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P17480	S546	Sugiyama	UBTF UBF UBF1	EKLMWIKKAAEDQKRYERELsEMRAPPAATNSSKKMKFQGE
P17812	S573	Sugiyama	CTPS1 CTPS	HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P21333	S1084	Sugiyama	FLNA FLN FLN1	PTKPSKVKAFGPGLQGGsAGsPARFtIDTKGAGTGGLGLTV
P22234	S27	Sugiyama	PAICS ADE2 AIRC PAIS	LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P29692	S133	Sugiyama	EEF1D EF1D	NVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPAEDDE
P30101	T485	Sugiyama	PDIA3 ERP57 ERP60 GRP58	KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P35613	S279	Sugiyama	BSG UNQ6505/PRO21383	TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P36578	S295	Sugiyama	RPL4 RPL1	sNyNLPMHKMINtDLsRILKsPEIQRALRAPRKKIHRRVLK
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P41252	S1047	Sugiyama	IARS1 IARS	ESHTEFIFTTIKAPLKPYPVsPsDKVLIQEKTQLKGSELEI
P42166	S159	Sugiyama	TMPO LAP2	RKLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsND
P42167	S159	Sugiyama	TMPO LAP2	RKLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSND
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243	S195	Sugiyama	MATR3 KIAA0723	RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P53999	S56	Sugiyama	SUB1 PC4 RPO2TC1	PVKKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRD
P54105	S102	Sugiyama	CLNS1A CLCI ICLN	VNAKFEEEsKEPVADEEEEDsDDDVEPITEFRFVPSDKSAL
P55081	S132	Sugiyama	MFAP1	VVGEsDsEVEGDAWRMEREDssEEEEEEIDDEEIERRRGMM
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62917	S14	Sugiyama	RPL8	_______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62942	S9	Sugiyama	FKBP1A FKBP1 FKBP12	____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P78345	S253	Sugiyama	RPP38	DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P84103	S95	Sugiyama	SRSF3 SFRS3 SRP20	RVRVELSNGEKRSRNRGPPPsWGRRPRDDYRRRSPPPRRRS
Q05519	S231	Sugiyama	SRSF11 SFRS11	KsDTsSKEIEEAMKRVREAQsLISAAIEPDKKEEKRRHSRS
Q13242	S211	Sugiyama	SRSF9 SFRS9 SRP30C	GYsRsRSGsRGRDsPyQsRGsPHyFsPFRPy__________
Q13242	S216	Sugiyama	SRSF9 SFRS9 SRP30C	RSGsRGRDsPyQsRGsPHyFsPFRPy_______________
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13442	S19	Sugiyama	PDAP1 HASPP28	__MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q14152	S1308	Sugiyama	EIF3A EIF3S10 KIAA0139	DLRDDRDRRGPPLRSEREEVsSWRRADDRKDDRVEERDPPR
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152	S895	Sugiyama	EIF3A EIF3S10 KIAA0139	ERRLGDssLSRKDSRWGDRDsEGtWRKGPEADsEWRRGPPE
Q14155	S518	Sugiyama	ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314	ERYLLLFPNVLLMLSASPRMsGFIyQGKLPtTGMTITKLED
Q15052	S488	Sugiyama	ARHGEF6 COOL2 KIAA0006 PIXA	ERYLMLFSNVLIMLSASPRMsGFIYQGKIPIAGTVVTRLDE
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16643	S255	Sugiyama	DBN1 D0S117E	HRRKQQTLEAEEAKRRLKEQsIFGDHRDEEEEtHMKKsEsE
Q16643	T267	Sugiyama	DBN1 D0S117E	AKRRLKEQsIFGDHRDEEEEtHMKKsEsEVEEAAAIIAQRP
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q4G0J3	S285	Sugiyama	LARP7 HDCMA18P	stEPQKQCSKKKKKRDRVEAssLPEVRTGKRKRsssEDAEs
Q4G0J3	S286	Sugiyama	LARP7 HDCMA18P	tEPQKQCSKKKKKRDRVEAssLPEVRTGKRKRsssEDAEsL
Q63ZY3	S356	Sugiyama	KANK2 ANKRD25 KIAA1518 MXRA3 SIP	PREVEVVASTAAGAPAQRAQsLEPYGtGLRALAMPGRPEsP
Q6PCE3	S175	Sugiyama	PGM2L1 BM32A	PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6UN15	S492	Sugiyama	FIP1L1 FIP1 RHE	DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15	S496	Sugiyama	FIP1L1 FIP1 RHE	DRERERTRERERERDHsPtPsVFNsDEERyRYREYAERGYE
Q6UN15	T494	Sugiyama	FIP1L1 FIP1 RHE	DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q86X29	S493	Sugiyama	LSR ILDR3 LISCH	QEPAREQAGGGWRARRPRARsVDALDDLtPPstAEsGsRsP
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBS9	S426	Sugiyama	TXNDC5 TLP46 UNQ364/PRO700	KKVSEHSGGRDLDSLHRFVLsQAKDEL______________
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q92995	Y708	GPS6\|SIGNOR\|PSP	USP13 ISOT3	NWIIVHMEEPDFAEPLTMPGyGGAASAGASVFGASGLDNQP
Q96C19	S74	Sugiyama	EFHD2 SWS1	ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96D46	S462	Sugiyama	NMD3 CGI-07	FLEDLEEDEAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAE
Q96EP5	S195	Sugiyama	DAZAP1	FHDIMGKKVEVKRAEPRDsKsQAPGQPGAsQWGsRVVPNAA
Q96JP5	S83	Sugiyama	ZFP91 ZNF757 FKSG11	AAAAAVSRRRKAEYPRRRRssPsARPPDVPGQQPQAAKsPs
Q96MH2	S76	Sugiyama	HEXIM2 L3	EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q96QK1	S786	Sugiyama	VPS35 MEM3 TCCCTA00141	INKHFHNtLEHLRLRREsPEsEGPIyEGLIL__________
Q96S44	T8	Sugiyama	TP53RK C20orf64 PRPK	_____________MAAARAttPADGEEPAPEAEALAAARER
Q96T37	T568	Sugiyama	RBM15 OTT OTT1	LVTDAFGHRAPDPLRGARDRtPPLLYRDRDRDLYPDSDWVP
Q9BQE3	S439	Sugiyama	TUBA1C TUBA6	SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BRS2	S507	Sugiyama	RIOK1 RIO1	ENQVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHTTDP
Q9BRS2	T509	Sugiyama	RIOK1 RIO1	QVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHTTDPDI
Q9BW71	S357	Sugiyama	HIRIP3	EDsGKGEPTAKGSRKMARLGstsGEEsDLEREVsDsEAGGG
Q9BXP5	S493	Sugiyama	SRRT ARS2 ASR2	VNIKEICWNLQNIRLRECELsPGVNRDLTRRVRNINGITQH
Q9BY44	S524	Sugiyama	EIF2A CDA02 MSTP004 MSTP089	DKsPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKL
Q9C0C2	S672	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H1E3	S204	Sugiyama	NUCKS1 NUCKS JC7	KGKGKVGRPTAsKAsKEKtPsPKEEDEEPEsPPEKKtstsP
Q9H1E3	T202	Sugiyama	NUCKS1 NUCKS JC7	PVKGKGKVGRPTAsKAsKEKtPsPKEEDEEPEsPPEKKtst
Q9H7D7	S121	Sugiyama	WDR26 CDW2 MIP2 PRO0852	ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9H7N4	S498	Sugiyama	SCAF1 SFRS19 SRA1	GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4	S500	Sugiyama	SCAF1 SFRS19 SRA1	LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9NYF8	S196	Sugiyama	BCLAF1 BTF KIAA0164	EsPLKsKsQEEPKDtFEHDPsEsIDEFNKssAtsGDIWPGL
Q9NYF8	S319	Sugiyama	BCLAF1 BTF KIAA0164	RsPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKR
Q9NYF8	S320	Sugiyama	BCLAF1 BTF KIAA0164	sPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRF
Q9NYV4	S249	Sugiyama	CDK12 CRK7 CRKRS KIAA0904	DSSKQDDsPsGAsYGQDyDLsPsRsHtssNYDsYKKsPGsT
Q9NZN8	S242	Sugiyama	CNOT2 CDC36 NOT2 HSPC131 MSTP046	VTGLDLSDFPALADRNRREGsGNPtPLINPLAGRAPYVGMV
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35	S1542	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDss
Q9UQ35	S1648	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	S2692	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ35	S323	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	RGEGDAPFsEPGttstQRPssPEtAtKQPssPYEDKDKDKK
Q9UQ35	S351	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	PssPYEDKDKDKKEKsAtRPsPsPERsstGPEPPAPtPLLA
Q9UQ35	S353	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPYEDKDKDKKEKsAtRPsPsPERsstGPEPPAPtPLLAER
Q9UQ35	S358	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	KDKDKKEKsAtRPsPsPERsstGPEPPAPtPLLAERHGGsP
Q9UQ35	T359	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	DKDKKEKsAtRPsPsPERsstGPEPPAPtPLLAERHGGsPQ
Q9Y2B0	S115	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y3U8	S91	Sugiyama	RPL36	KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y5S9	S56	Sugiyama	RBM8A RBM8 HSPC114 MDS014	KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.507484e-09	8.601
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	8.452476e-08	7.073
Cell Cycle	R-HSA-1640170	1.379094e-07	6.860
Cell Cycle, Mitotic	R-HSA-69278	3.543398e-07	6.451
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.128890e-07	6.384
Chromatin organization	R-HSA-4839726	5.029779e-07	6.298
Chromatin modifying enzymes	R-HSA-3247509	4.283742e-06	5.368
Apoptotic execution phase	R-HSA-75153	3.997955e-06	5.398
mRNA Splicing	R-HSA-72172	7.121111e-06	5.147
mRNA Splicing - Major Pathway	R-HSA-72163	9.685183e-06	5.014
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.240521e-05	4.906
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	3.297461e-05	4.482
mRNA 3'-end processing	R-HSA-72187	5.526150e-05	4.258
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	7.496185e-05	4.125
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	8.298712e-05	4.081
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	9.158001e-05	4.038
Nuclear import of Rev protein	R-HSA-180746	9.671652e-05	4.014
RNA Polymerase II Transcription Termination	R-HSA-73856	1.051654e-04	3.978
Interactions of Rev with host cellular proteins	R-HSA-177243	1.154232e-04	3.938
Polo-like kinase mediated events	R-HSA-156711	1.427715e-04	3.845
M Phase	R-HSA-68886	1.772905e-04	3.751
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.126735e-04	3.672
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.476554e-04	3.606
Mitotic Prometaphase	R-HSA-68877	3.106190e-04	3.508
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.662994e-04	3.436
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	3.862407e-04	3.413
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.862407e-04	3.413
Apoptosis induced DNA fragmentation	R-HSA-140342	4.026184e-04	3.395
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	4.252273e-04	3.371
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.252273e-04	3.371
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	4.652696e-04	3.332
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	4.652696e-04	3.332
G0 and Early G1	R-HSA-1538133	5.858638e-04	3.232
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.858638e-04	3.232
Epigenetic regulation of gene expression	R-HSA-212165	6.125030e-04	3.213
Vpr-mediated nuclear import of PICs	R-HSA-180910	6.502464e-04	3.187
IPs transport between nucleus and cytosol	R-HSA-1855170	7.316618e-04	3.136
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	9.066280e-04	3.043
NRAGE signals death through JNK	R-HSA-193648	9.753737e-04	3.011
NS1 Mediated Effects on Host Pathways	R-HSA-168276	9.682212e-04	3.014
Nuclear Envelope Breakdown	R-HSA-2980766	1.141390e-03	2.943
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.170589e-03	2.932
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.281868e-03	2.892
Signaling by ALK in cancer	R-HSA-9700206	1.281868e-03	2.892
Mitotic G2-G2/M phases	R-HSA-453274	1.351133e-03	2.869
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.407046e-03	2.852
PKMTs methylate histone lysines	R-HSA-3214841	1.407046e-03	2.852
Regulation of TP53 Activity	R-HSA-5633007	1.460602e-03	2.835
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.959228e-03	2.708
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.973413e-03	2.705
HATs acetylate histones	R-HSA-3214847	2.197564e-03	2.658
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.333935e-03	2.632
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.333935e-03	2.632
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.442087e-03	2.463
G2/M Transition	R-HSA-69275	3.727816e-03	2.429
Gene expression (Transcription)	R-HSA-74160	3.581210e-03	2.446
Late Phase of HIV Life Cycle	R-HSA-162599	3.978848e-03	2.400
Cell Cycle Checkpoints	R-HSA-69620	4.227231e-03	2.374
Activation of RAC1	R-HSA-428540	4.455310e-03	2.351
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	4.529302e-03	2.344
ATP-dependent chromatin remodelers	R-HSA-9932444	4.669435e-03	2.331
SWI/SNF chromatin remodelers	R-HSA-9932451	4.669435e-03	2.331
G1/S-Specific Transcription	R-HSA-69205	4.800081e-03	2.319
Mitotic Spindle Checkpoint	R-HSA-69618	5.057293e-03	2.296
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	5.661611e-03	2.247
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	5.698628e-03	2.244
Mitotic Anaphase	R-HSA-68882	6.158136e-03	2.211
Mitotic Metaphase and Anaphase	R-HSA-2555396	6.559161e-03	2.183
Transcriptional regulation by RUNX1	R-HSA-8878171	6.968829e-03	2.157
HIV Life Cycle	R-HSA-162587	7.044160e-03	2.152
Transcriptional Regulation by MECP2	R-HSA-8986944	7.085101e-03	2.150
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	7.751597e-03	2.111
Amplification of signal from the kinetochores	R-HSA-141424	7.982761e-03	2.098
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	7.982761e-03	2.098
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	8.364733e-03	2.078
Metabolism of non-coding RNA	R-HSA-194441	9.006785e-03	2.045
snRNP Assembly	R-HSA-191859	9.006785e-03	2.045
Inositol phosphate metabolism	R-HSA-1483249	8.487397e-03	2.071
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	9.087077e-03	2.042
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	9.091287e-03	2.041
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	9.091287e-03	2.041
Apoptosis	R-HSA-109581	1.004098e-02	1.998
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	9.583967e-03	2.018
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.010772e-02	1.995
Mitotic Prophase	R-HSA-68875	1.040554e-02	1.983
ISG15 antiviral mechanism	R-HSA-1169408	1.121703e-02	1.950
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.126659e-02	1.948
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.155647e-02	1.937
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.334390e-02	1.875
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.418509e-02	1.848
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.420674e-02	1.848
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.420674e-02	1.848
G alpha (12/13) signalling events	R-HSA-416482	1.512758e-02	1.820
Metabolism of RNA	R-HSA-8953854	1.609251e-02	1.793
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.754954e-02	1.756
MECP2 regulates transcription factors	R-HSA-9022707	1.901481e-02	1.721
Cohesin Loading onto Chromatin	R-HSA-2470946	1.901481e-02	1.721
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.901481e-02	1.721
AURKA Activation by TPX2	R-HSA-8854518	1.943135e-02	1.711
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.889870e-02	1.724
Regulation of MECP2 expression and activity	R-HSA-9022692	1.850983e-02	1.733
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.681870e-02	1.774
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.827167e-02	1.738
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.901481e-02	1.721
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.850983e-02	1.733
S Phase	R-HSA-69242	1.931350e-02	1.714
Signaling by NTRKs	R-HSA-166520	1.931350e-02	1.714
Transcriptional Regulation by TP53	R-HSA-3700989	1.837105e-02	1.736
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.949045e-02	1.710
Formation of RNA Pol II elongation complex	R-HSA-112382	2.002447e-02	1.698
Cellular response to heat stress	R-HSA-3371556	2.019301e-02	1.695
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.370966e-02	1.625
mRNA Splicing - Minor Pathway	R-HSA-72165	2.246059e-02	1.649
RNA Polymerase II Transcription Elongation	R-HSA-75955	2.237034e-02	1.650
Centrosome maturation	R-HSA-380287	2.280626e-02	1.642
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	2.226684e-02	1.652
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.370966e-02	1.625
Regulation of PTEN gene transcription	R-HSA-8943724	2.200993e-02	1.657
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.364560e-02	1.626
Programmed Cell Death	R-HSA-5357801	2.178630e-02	1.662
Viral Messenger RNA Synthesis	R-HSA-168325	2.436798e-02	1.613
RAF activation	R-HSA-5673000	2.447067e-02	1.611
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.476573e-02	1.606
Signaling by MRAS-complex mutants	R-HSA-9660537	2.577966e-02	1.589
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.577966e-02	1.589
Heme signaling	R-HSA-9707616	2.690760e-02	1.570
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.828733e-02	1.548
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.850589e-02	1.545
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	3.078912e-02	1.512
Frs2-mediated activation	R-HSA-170968	2.965171e-02	1.528
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.976506e-02	1.526
p75 NTR receptor-mediated signalling	R-HSA-193704	3.197842e-02	1.495
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.380585e-02	1.471
Inactivation of CDC42 and RAC1	R-HSA-428543	3.382070e-02	1.471
AKT phosphorylates targets in the nucleus	R-HSA-198693	3.382070e-02	1.471
Transcriptional regulation by small RNAs	R-HSA-5578749	3.406219e-02	1.468
RNA Polymerase II Transcription	R-HSA-73857	3.447760e-02	1.462
Regulation of endogenous retroelements	R-HSA-9842860	3.968381e-02	1.401
Diseases of mitotic cell cycle	R-HSA-9675126	4.011919e-02	1.397
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.086596e-02	1.389
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.316396e-02	1.365
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.491570e-02	1.348
Cardiogenesis	R-HSA-9733709	4.542137e-02	1.343
Nuclear RNA decay	R-HSA-9930044	4.542137e-02	1.343
DNA Double-Strand Break Repair	R-HSA-5693532	4.251621e-02	1.371
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	4.475668e-02	1.349
Death Receptor Signaling	R-HSA-73887	4.491570e-02	1.348
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.634163e-02	1.334
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	4.750121e-02	1.323
Negative feedback regulation of MAPK pathway	R-HSA-5674499	4.750121e-02	1.323
Homology Directed Repair	R-HSA-5693538	4.806103e-02	1.318
Separation of Sister Chromatids	R-HSA-2467813	4.902997e-02	1.310
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.273147e-02	1.278
Prolonged ERK activation events	R-HSA-169893	5.273147e-02	1.278
tRNA processing in the nucleus	R-HSA-6784531	5.328999e-02	1.273
Formation of the posterior neural plate	R-HSA-9832991	5.381353e-02	1.269
Regulation of cortical dendrite branching	R-HSA-8985801	6.164521e-02	1.210
Signaling by PDGFR in disease	R-HSA-9671555	5.680575e-02	1.246
HIV elongation arrest and recovery	R-HSA-167287	5.791360e-02	1.237
Pausing and recovery of HIV elongation	R-HSA-167290	5.791360e-02	1.237
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.985469e-02	1.223
Regulation of TP53 Expression	R-HSA-6804754	6.164521e-02	1.210
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	5.680575e-02	1.246
Sensory processing of sound	R-HSA-9659379	5.962805e-02	1.225
Disorders of Developmental Biology	R-HSA-9675151	6.222320e-02	1.206
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.222320e-02	1.206
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.222320e-02	1.206
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	6.222320e-02	1.206
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	6.222320e-02	1.206
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.222320e-02	1.206
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	6.296282e-02	1.201
G2/M DNA replication checkpoint	R-HSA-69478	6.296282e-02	1.201
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	6.372447e-02	1.196
Signalling to ERKs	R-HSA-187687	6.399683e-02	1.194
Signaling by AXIN mutants	R-HSA-4839735	6.575358e-02	1.182
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	6.575358e-02	1.182
Mitotic Telophase/Cytokinesis	R-HSA-68884	6.575358e-02	1.182
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	6.665148e-02	1.176
PI Metabolism	R-HSA-1483255	6.749722e-02	1.171
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	6.864079e-02	1.163
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	7.261456e-02	1.139
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	7.336568e-02	1.135
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.866423e-02	1.104
Cellular Senescence	R-HSA-2559583	7.394626e-02	1.131
RET signaling	R-HSA-8853659	7.109992e-02	1.148
Pervasive developmental disorders	R-HSA-9005895	7.895051e-02	1.103
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	7.895051e-02	1.103
Disorders of Nervous System Development	R-HSA-9697154	7.895051e-02	1.103
DNA Double Strand Break Response	R-HSA-5693606	7.922685e-02	1.101
SOS-mediated signalling	R-HSA-112412	8.043854e-02	1.095
Cation-coupled Chloride cotransporters	R-HSA-426117	8.043854e-02	1.095
Displacement of DNA glycosylase by APEX1	R-HSA-110357	8.043854e-02	1.095
Drug resistance of PDGFR mutants	R-HSA-9674415	9.526091e-02	1.021
PDGFR mutants bind TKIs	R-HSA-9674428	9.526091e-02	1.021
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.526091e-02	1.021
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	9.526091e-02	1.021
Imatinib-resistant PDGFR mutants	R-HSA-9674396	9.526091e-02	1.021
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	9.526091e-02	1.021
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	9.526091e-02	1.021
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	9.526091e-02	1.021
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	9.526091e-02	1.021
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	9.034059e-02	1.044
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	9.034059e-02	1.044
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	9.335535e-02	1.030
Deadenylation of mRNA	R-HSA-429947	8.404944e-02	1.075
Nucleosome assembly	R-HSA-774815	8.953470e-02	1.048
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	8.953470e-02	1.048
Transcription of the HIV genome	R-HSA-167172	8.522928e-02	1.069
FOXO-mediated transcription of cell death genes	R-HSA-9614657	8.389271e-02	1.076
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.404944e-02	1.075
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	9.335535e-02	1.030
Protein-protein interactions at synapses	R-HSA-6794362	8.992699e-02	1.046
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	9.034059e-02	1.044
Deubiquitination	R-HSA-5688426	9.349656e-02	1.029
Sema4D in semaphorin signaling	R-HSA-400685	9.448906e-02	1.025
G2/M Checkpoints	R-HSA-69481	8.469481e-02	1.072
HIV Infection	R-HSA-162906	8.870725e-02	1.052
Transcriptional regulation of granulopoiesis	R-HSA-9616222	9.858192e-02	1.006
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	9.975577e-02	1.001
Activation of ATR in response to replication stress	R-HSA-176187	1.006727e-01	0.997
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.038313e-01	0.984
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.048910e-01	0.979
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.055894e-01	0.976
HDACs deacetylate histones	R-HSA-3214815	1.062285e-01	0.974
Host Interactions of HIV factors	R-HSA-162909	1.064036e-01	0.973
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.089061e-01	0.963
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.089061e-01	0.963
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.090192e-01	0.962
Signal Transduction	R-HSA-162582	1.107707e-01	0.956
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.108552e-01	0.955
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.119950e-01	0.951
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.143316e-01	0.942
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.814523e-01	0.741
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.814523e-01	0.741
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.814523e-01	0.741
Diseases of Telomere Maintenance	R-HSA-9673013	1.814523e-01	0.741
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.814523e-01	0.741
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.814523e-01	0.741
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	1.814523e-01	0.741
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	1.814523e-01	0.741
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.814523e-01	0.741
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.814523e-01	0.741
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.220855e-01	0.913
Regulation of HMOX1 expression and activity	R-HSA-9707587	1.220855e-01	0.913
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.220855e-01	0.913
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.220855e-01	0.913
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.220855e-01	0.913
Signaling by MAP2K mutants	R-HSA-9652169	1.220855e-01	0.913
Interactions of Tat with host cellular proteins	R-HSA-176034	2.594371e-01	0.586
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.594371e-01	0.586
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	2.594371e-01	0.586
Signaling by TCF7L2 mutants	R-HSA-5339700	2.594371e-01	0.586
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.594371e-01	0.586
PTEN Loss of Function in Cancer	R-HSA-5674404	2.594371e-01	0.586
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.594371e-01	0.586
Defective SLC9A9 causes autism 16 (AUTS16)	R-HSA-5619052	2.594371e-01	0.586
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.560393e-01	0.807
IRS activation	R-HSA-74713	1.560393e-01	0.807
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.560393e-01	0.807
G2 Phase	R-HSA-68911	1.560393e-01	0.807
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.560393e-01	0.807
ALK mutants bind TKIs	R-HSA-9700645	1.207231e-01	0.918
Signalling to p38 via RIT and RIN	R-HSA-187706	1.914937e-01	0.718
Phosphorylation of Emi1	R-HSA-176417	1.914937e-01	0.718
PDE3B signalling	R-HSA-165160	1.914937e-01	0.718
PKB-mediated events	R-HSA-109703	1.914937e-01	0.718
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	1.914937e-01	0.718
Synthesis of PS	R-HSA-1483101	1.914937e-01	0.718
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	3.299963e-01	0.481
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	3.299963e-01	0.481
Defective PAPSS2 causes SEMD-PA	R-HSA-3560796	3.299963e-01	0.481
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	3.299963e-01	0.481
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	3.299963e-01	0.481
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	3.299963e-01	0.481
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.299963e-01	0.481
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	3.299963e-01	0.481
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	3.299963e-01	0.481
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	3.299963e-01	0.481
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	3.299963e-01	0.481
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	3.299963e-01	0.481
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	3.299963e-01	0.481
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	3.299963e-01	0.481
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	3.299963e-01	0.481
MET activates RAP1 and RAC1	R-HSA-8875555	1.431386e-01	0.844
Signaling by APC mutants	R-HSA-4839744	1.667966e-01	0.778
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.667966e-01	0.778
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.667966e-01	0.778
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.667966e-01	0.778
Condensation of Prometaphase Chromosomes	R-HSA-2514853	1.914924e-01	0.718
Signaling by GSK3beta mutants	R-HSA-5339716	1.914924e-01	0.718
Regulation of PTEN localization	R-HSA-8948747	2.646296e-01	0.577
Activation of BIM and translocation to mitochondria	R-HSA-111446	3.938365e-01	0.405
Defective MMACHC causes MAHCC	R-HSA-3359474	3.938365e-01	0.405
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	3.938365e-01	0.405
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.938365e-01	0.405
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.938365e-01	0.405
Invadopodia formation	R-HSA-8941237	3.938365e-01	0.405
MET activates PTPN11	R-HSA-8865999	3.938365e-01	0.405
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.228050e-01	0.911
Repression of WNT target genes	R-HSA-4641265	2.170269e-01	0.663
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.170269e-01	0.663
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.170269e-01	0.663
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.170269e-01	0.663
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.170269e-01	0.663
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.170269e-01	0.663
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.173328e-01	0.931
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.173328e-01	0.931
Formation of annular gap junctions	R-HSA-196025	3.014086e-01	0.521
Notch-HLH transcription pathway	R-HSA-350054	1.526221e-01	0.816
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.432090e-01	0.614
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.432090e-01	0.614
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.010453e-01	0.697
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.217136e-01	0.654
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.217136e-01	0.654
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.217136e-01	0.654
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.378577e-01	0.471
Gap junction degradation	R-HSA-190873	3.378577e-01	0.471
TNFR1-mediated ceramide production	R-HSA-5626978	4.515973e-01	0.345
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.515973e-01	0.345
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.515973e-01	0.345
Signaling by LRP5 mutants	R-HSA-5339717	4.515973e-01	0.345
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	2.429055e-01	0.615
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.429055e-01	0.615
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.429055e-01	0.615
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.429055e-01	0.615
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.429055e-01	0.615
Erythropoietin activates RAS	R-HSA-9027284	2.968055e-01	0.528
Beta-catenin phosphorylation cascade	R-HSA-196299	2.968055e-01	0.528
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.737061e-01	0.427
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.315434e-01	0.881
EPHA-mediated growth cone collapse	R-HSA-3928663	2.379144e-01	0.624
Differentiation of T cells	R-HSA-9945266	3.238954e-01	0.490
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	3.238954e-01	0.490
Phosphorylation of the APC/C	R-HSA-176412	3.238954e-01	0.490
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.958127e-01	0.708
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.958127e-01	0.708
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.500575e-01	0.824
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.751507e-01	0.560
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	3.509852e-01	0.455
Activation of the pre-replicative complex	R-HSA-68962	2.942035e-01	0.531
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	3.534783e-01	0.452
ERKs are inactivated	R-HSA-202670	4.427826e-01	0.354
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	3.149808e-01	0.502
Ephrin signaling	R-HSA-3928664	4.046622e-01	0.393
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	3.759142e-01	0.425
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	2.595351e-01	0.586
Nuclear Receptor transcription pathway	R-HSA-383280	2.483729e-01	0.605
HIV Transcription Elongation	R-HSA-167169	3.323490e-01	0.478
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	3.323490e-01	0.478
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.719890e-01	0.429
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.982772e-01	0.400
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.757111e-01	0.323
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.757111e-01	0.323
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	4.757111e-01	0.323
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.511397e-01	0.259
Signaling by MAPK mutants	R-HSA-9652817	5.511397e-01	0.259
Signaling by RNF43 mutants	R-HSA-5340588	5.511397e-01	0.259
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.116041e-01	0.506
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.915621e-01	0.407
Interaction between L1 and Ankyrins	R-HSA-445095	4.205000e-01	0.376
Co-inhibition by CTLA4	R-HSA-389513	4.569638e-01	0.340
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.425207e-01	0.354
Formation of the Early Elongation Complex	R-HSA-113418	4.425207e-01	0.354
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.108208e-01	0.386
Signaling by Erythropoietin	R-HSA-9006335	4.642826e-01	0.333
Late endosomal microautophagy	R-HSA-9615710	4.642826e-01	0.333
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.642826e-01	0.333
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.498127e-01	0.347
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	4.549706e-01	0.342
Signaling downstream of RAS mutants	R-HSA-9649948	4.549706e-01	0.342
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	4.549706e-01	0.342
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.072179e-01	0.295
Erythropoietin activates STAT5	R-HSA-9027283	5.939187e-01	0.226
STAT5 Activation	R-HSA-9645135	5.939187e-01	0.226
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.939187e-01	0.226
Attenuation phase	R-HSA-3371568	5.064988e-01	0.295
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	5.064988e-01	0.295
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.669719e-01	0.246
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.669719e-01	0.246
Translesion synthesis by REV1	R-HSA-110312	5.669719e-01	0.246
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.669719e-01	0.246
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.549330e-01	0.256
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.549330e-01	0.256
MAP2K and MAPK activation	R-HSA-5674135	5.429595e-01	0.265
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	5.429595e-01	0.265
HIV Transcription Initiation	R-HSA-167161	5.429595e-01	0.265
RNA Polymerase II Transcription Initiation	R-HSA-75953	5.429595e-01	0.265
HSF1-dependent transactivation	R-HSA-3371571	5.394146e-01	0.268
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.344884e-01	0.272
Regulation of mitotic cell cycle	R-HSA-453276	5.344884e-01	0.272
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	5.517162e-01	0.258
Orc1 removal from chromatin	R-HSA-68949	5.556387e-01	0.255
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	5.556387e-01	0.255
Translesion synthesis by POLI	R-HSA-5656121	5.947337e-01	0.226
RUNX3 regulates WNT signaling	R-HSA-8951430	6.326230e-01	0.199
MET activates PI3K/AKT signaling	R-HSA-8851907	6.326230e-01	0.199
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.326230e-01	0.199
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.326230e-01	0.199
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	6.326230e-01	0.199
Disinhibition of SNARE formation	R-HSA-114516	6.326230e-01	0.199
DAG1 core M1 glycosylations	R-HSA-8932506	6.326230e-01	0.199
Golgi Associated Vesicle Biogenesis	R-HSA-432722	5.715931e-01	0.243
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	5.715931e-01	0.243
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	5.715931e-01	0.243
RNA Polymerase II Promoter Escape	R-HSA-73776	5.781003e-01	0.238
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.026261e-01	0.220
Translesion synthesis by POLK	R-HSA-5655862	6.211396e-01	0.207
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	6.117521e-01	0.213
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	6.176760e-01	0.209
PRC2 methylates histones and DNA	R-HSA-212300	6.239749e-01	0.205
Condensation of Prophase Chromosomes	R-HSA-2299718	6.279781e-01	0.202
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	6.279781e-01	0.202
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	6.467831e-01	0.189
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	6.437868e-01	0.191
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.676403e-01	0.175
DAG1 core M2 glycosylations	R-HSA-8932504	6.676403e-01	0.175
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.676403e-01	0.175
MET receptor recycling	R-HSA-8875656	6.676403e-01	0.175
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.676403e-01	0.175
G beta:gamma signalling through PLC beta	R-HSA-418217	6.699197e-01	0.174
DNA methylation	R-HSA-5334118	6.801378e-01	0.167
PTEN Regulation	R-HSA-6807070	2.257049e-01	0.646
Degradation of beta-catenin by the destruction complex	R-HSA-195253	3.806403e-01	0.419
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	5.375875e-01	0.270
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.797076e-01	0.553
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	5.375875e-01	0.270
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	5.375875e-01	0.270
Processing of DNA double-strand break ends	R-HSA-5693607	1.171291e-01	0.931
Adipogenesis	R-HSA-9843745	2.266572e-01	0.645
Downstream signal transduction	R-HSA-186763	5.068306e-01	0.295
Aggrephagy	R-HSA-9646399	3.323490e-01	0.478
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	5.064988e-01	0.295
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	5.064988e-01	0.295
IRS-related events triggered by IGF1R	R-HSA-2428928	1.597844e-01	0.796
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.074267e-01	0.295
Oncogenic MAPK signaling	R-HSA-6802957	1.472943e-01	0.832
DNA Damage Bypass	R-HSA-73893	5.062342e-01	0.296
EPH-Ephrin signaling	R-HSA-2682334	5.686170e-01	0.245
mRNA Capping	R-HSA-72086	6.801378e-01	0.167
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	4.402791e-01	0.356
Telomere Extension By Telomerase	R-HSA-171319	6.612377e-01	0.180
PIP3 activates AKT signaling	R-HSA-1257604	1.841060e-01	0.735
IRS-mediated signalling	R-HSA-112399	2.088831e-01	0.680
p75NTR recruits signalling complexes	R-HSA-209543	4.757111e-01	0.323
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.170269e-01	0.663
DNA Replication Pre-Initiation	R-HSA-69002	5.517134e-01	0.258
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	4.226392e-01	0.374
FOXO-mediated transcription	R-HSA-9614085	5.419105e-01	0.266
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	2.646296e-01	0.577
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.205000e-01	0.376
Signaling by RAF1 mutants	R-HSA-9656223	5.429595e-01	0.265
Type I hemidesmosome assembly	R-HSA-446107	3.014086e-01	0.521
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.998664e-01	0.699
PI3K Cascade	R-HSA-109704	2.295003e-01	0.639
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.074267e-01	0.295
Interleukin receptor SHC signaling	R-HSA-912526	5.549330e-01	0.256
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	6.539050e-01	0.184
Assembly of the pre-replicative complex	R-HSA-68867	3.388149e-01	0.470
Germ layer formation at gastrulation	R-HSA-9754189	2.217136e-01	0.654
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.509852e-01	0.455
UCH proteinases	R-HSA-5689603	3.350247e-01	0.475
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	5.072179e-01	0.295
Signaling by WNT in cancer	R-HSA-4791275	1.848276e-01	0.733
Nucleotide Excision Repair	R-HSA-5696398	5.054465e-01	0.296
LGI-ADAM interactions	R-HSA-5682910	1.667966e-01	0.778
PI3K/AKT activation	R-HSA-198203	3.737061e-01	0.427
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	2.977627e-01	0.526
Switching of origins to a post-replicative state	R-HSA-69052	2.966494e-01	0.528
G1/S Transition	R-HSA-69206	1.172092e-01	0.931
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	5.869097e-01	0.231
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.915621e-01	0.407
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	2.679875e-01	0.572
Signaling by RAS mutants	R-HSA-6802949	4.549706e-01	0.342
Resolution of D-Loop Structures	R-HSA-5693537	3.719890e-01	0.429
p75NTR signals via NF-kB	R-HSA-193639	5.669719e-01	0.246
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.024733e-01	0.694
IGF1R signaling cascade	R-HSA-2428924	1.907331e-01	0.720
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.725201e-01	0.429
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.725201e-01	0.429
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.725201e-01	0.429
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.725201e-01	0.429
Insulin receptor signalling cascade	R-HSA-74751	2.981105e-01	0.526
NTRK3 as a dependence receptor	R-HSA-9603505	2.594371e-01	0.586
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.560393e-01	0.807
Reelin signalling pathway	R-HSA-8866376	1.560393e-01	0.807
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	2.170269e-01	0.663
Adrenoceptors	R-HSA-390696	3.014086e-01	0.521
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.432090e-01	0.614
Regulation of gap junction activity	R-HSA-191650	4.515973e-01	0.345
TGFBR3 expression	R-HSA-9839394	3.759142e-01	0.425
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	3.524152e-01	0.453
E2F mediated regulation of DNA replication	R-HSA-113510	4.310315e-01	0.365
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.757111e-01	0.323
Trafficking of AMPA receptors	R-HSA-399719	5.068306e-01	0.295
TRAF6 mediated NF-kB activation	R-HSA-933542	5.777285e-01	0.238
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.676403e-01	0.175
Signaling by FGFR1 in disease	R-HSA-5655302	1.233363e-01	0.909
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.857346e-01	0.314
Signaling by ERBB2 ECD mutants	R-HSA-9665348	4.046622e-01	0.393
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.163344e-01	0.665
Intracellular signaling by second messengers	R-HSA-9006925	2.854554e-01	0.544
Signal attenuation	R-HSA-74749	1.431386e-01	0.844
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	3.779460e-01	0.423
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	4.757111e-01	0.323
Clathrin-mediated endocytosis	R-HSA-8856828	2.666331e-01	0.574
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	6.026261e-01	0.220
Downstream signaling of activated FGFR3	R-HSA-5654708	6.801378e-01	0.167
Neurexins and neuroligins	R-HSA-6794361	1.530319e-01	0.815
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.016027e-01	0.696
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	1.560393e-01	0.807
Calcineurin activates NFAT	R-HSA-2025928	1.207231e-01	0.918
Josephin domain DUBs	R-HSA-5689877	3.737061e-01	0.427
Activation of AKT2	R-HSA-165158	5.038571e-01	0.298
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.038571e-01	0.298
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.427826e-01	0.354
Circadian clock	R-HSA-9909396	1.667513e-01	0.778
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	4.757111e-01	0.323
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	4.757111e-01	0.323
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.725201e-01	0.429
RAF-independent MAPK1/3 activation	R-HSA-112409	5.314171e-01	0.275
PTK6 Expression	R-HSA-8849473	6.326230e-01	0.199
Phase 2 - plateau phase	R-HSA-5576893	6.211396e-01	0.207
TCF dependent signaling in response to WNT	R-HSA-201681	6.382023e-01	0.195
Signaling by ROBO receptors	R-HSA-376176	1.786777e-01	0.748
Signaling by ERBB2 KD Mutants	R-HSA-9664565	6.801378e-01	0.167
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.751507e-01	0.560
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	5.675982e-01	0.246
FGFR1 mutant receptor activation	R-HSA-1839124	3.524152e-01	0.453
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.998664e-01	0.699
mTORC1-mediated signalling	R-HSA-166208	3.086821e-01	0.510
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.234076e-01	0.205
Cilium Assembly	R-HSA-5617833	3.525218e-01	0.453
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	3.433620e-01	0.464
Golgi-to-ER retrograde transport	R-HSA-8856688	1.667513e-01	0.778
DNA Repair	R-HSA-73894	1.836244e-01	0.736
Chromosome Maintenance	R-HSA-73886	3.780101e-01	0.422
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.914937e-01	0.718
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.667966e-01	0.778
Inhibition of nitric oxide production	R-HSA-9636249	3.938365e-01	0.405
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.515973e-01	0.345
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.515973e-01	0.345
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.086821e-01	0.510
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.038571e-01	0.298
Elevation of cytosolic Ca2+ levels	R-HSA-139853	3.779460e-01	0.423
Negative regulation of the PI3K/AKT network	R-HSA-199418	4.842558e-01	0.315
Estrogen-dependent gene expression	R-HSA-9018519	2.777589e-01	0.556
Cyclin D associated events in G1	R-HSA-69231	2.682435e-01	0.571
G1 Phase	R-HSA-69236	2.682435e-01	0.571
TNF signaling	R-HSA-75893	4.588707e-01	0.338
COPI-mediated anterograde transport	R-HSA-6807878	3.861973e-01	0.413
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.560393e-01	0.807
Neurofascin interactions	R-HSA-447043	2.278552e-01	0.642
Downregulation of ERBB2 signaling	R-HSA-8863795	1.561895e-01	0.806
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	4.427826e-01	0.354
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.248818e-01	0.280
RNA Polymerase I Transcription	R-HSA-73864	6.289290e-01	0.201
Signaling by Hippo	R-HSA-2028269	1.809971e-01	0.742
Signaling by ERBB2	R-HSA-1227986	1.500575e-01	0.824
Signaling by SCF-KIT	R-HSA-1433557	5.781003e-01	0.238
Signaling by EGFR	R-HSA-177929	6.176760e-01	0.209
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	3.378577e-01	0.471
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.698127e-01	0.770
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	4.619565e-01	0.335
MTOR signalling	R-HSA-165159	3.849669e-01	0.415
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.797076e-01	0.553
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.096543e-01	0.678
Mismatch Repair	R-HSA-5358508	6.699197e-01	0.174
Rab regulation of trafficking	R-HSA-9007101	3.361641e-01	0.473
NGF-stimulated transcription	R-HSA-9031628	2.034659e-01	0.692
Regulation of TNFR1 signaling	R-HSA-5357905	4.549706e-01	0.342
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	6.590920e-01	0.181
Transcriptional regulation by RUNX3	R-HSA-8878159	6.393600e-01	0.194
Formation of editosomes by ADAR proteins	R-HSA-77042	1.814523e-01	0.741
SDK interactions	R-HSA-373756	1.814523e-01	0.741
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	2.594371e-01	0.586
Unwinding of DNA	R-HSA-176974	1.207231e-01	0.918
mRNA Editing: A to I Conversion	R-HSA-75064	3.299963e-01	0.481
C6 deamination of adenosine	R-HSA-75102	3.299963e-01	0.481
Interleukin-33 signaling	R-HSA-9014843	3.299963e-01	0.481
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.299963e-01	0.481
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	2.278552e-01	0.642
Signaling by AMER1 mutants	R-HSA-4839748	1.914924e-01	0.718
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	3.938365e-01	0.405
MET interacts with TNS proteins	R-HSA-8875513	3.938365e-01	0.405
Signaling by LTK	R-HSA-9842663	2.170269e-01	0.663
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.515973e-01	0.345
Bicarbonate transporters	R-HSA-425381	4.087377e-01	0.389
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.038571e-01	0.298
Deadenylation-dependent mRNA decay	R-HSA-429914	2.332587e-01	0.632
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.427826e-01	0.354
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	4.046622e-01	0.393
CDC6 association with the ORC:origin complex	R-HSA-68689	5.511397e-01	0.259
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.915621e-01	0.407
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.947337e-01	0.226
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	5.947337e-01	0.226
Cell junction organization	R-HSA-446728	5.862358e-01	0.232
Cell-cell junction organization	R-HSA-421270	6.863446e-01	0.163
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.461958e-01	0.190
Regulation of FZD by ubiquitination	R-HSA-4641263	6.461958e-01	0.190
MET promotes cell motility	R-HSA-8875878	6.588596e-01	0.181
Activation of kainate receptors upon glutamate binding	R-HSA-451326	6.612377e-01	0.180
Presynaptic function of Kainate receptors	R-HSA-500657	6.699197e-01	0.174
Membrane Trafficking	R-HSA-199991	2.419004e-01	0.616
Adherens junctions interactions	R-HSA-418990	6.750045e-01	0.171
Transcriptional Regulation by E2F6	R-HSA-8953750	1.823492e-01	0.739
Signaling by FGFR in disease	R-HSA-1226099	4.366262e-01	0.360
Synthesis of DNA	R-HSA-69239	6.442924e-01	0.191
Axon guidance	R-HSA-422475	2.124438e-01	0.673
Activation of BH3-only proteins	R-HSA-114452	1.561895e-01	0.806
Chaperone Mediated Autophagy	R-HSA-9613829	4.046622e-01	0.393
Oncogene Induced Senescence	R-HSA-2559585	4.110868e-01	0.386
Negative regulation of MAPK pathway	R-HSA-5675221	2.238469e-01	0.650
Cell-Cell communication	R-HSA-1500931	5.678349e-01	0.246
Regulation of CDH1 Expression and Function	R-HSA-9764265	6.415517e-01	0.193
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	6.415517e-01	0.193
Signaling by FGFR4 in disease	R-HSA-5655291	2.698581e-01	0.569
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	5.549330e-01	0.256
Transcriptional Regulation by VENTX	R-HSA-8853884	2.096543e-01	0.678
Signaling by NOTCH1	R-HSA-1980143	3.350247e-01	0.475
Generic Transcription Pathway	R-HSA-212436	3.637904e-01	0.439
Nervous system development	R-HSA-9675108	2.082940e-01	0.681
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	1.255299e-01	0.901
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	5.415666e-01	0.266
Transcriptional regulation of testis differentiation	R-HSA-9690406	6.211396e-01	0.207
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.461958e-01	0.190
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	3.480226e-01	0.458
Regulation of CDH11 gene transcription	R-HSA-9762293	1.207231e-01	0.918
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.378577e-01	0.471
ERK/MAPK targets	R-HSA-198753	2.645257e-01	0.578
Kinesins	R-HSA-983189	1.500575e-01	0.824
Acetylcholine regulates insulin secretion	R-HSA-399997	3.509852e-01	0.455
Ovarian tumor domain proteases	R-HSA-5689896	2.807348e-01	0.552
Myogenesis	R-HSA-525793	3.982772e-01	0.400
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	6.676403e-01	0.175
Oxidative Stress Induced Senescence	R-HSA-2559580	5.773119e-01	0.239
Ub-specific processing proteases	R-HSA-5689880	6.415517e-01	0.193
FLT3 signaling in disease	R-HSA-9682385	2.639375e-01	0.578
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	3.073354e-01	0.512
Organelle biogenesis and maintenance	R-HSA-1852241	5.260129e-01	0.279
G2/M DNA damage checkpoint	R-HSA-69473	2.048742e-01	0.689
Evasion by RSV of host interferon responses	R-HSA-9833109	5.068306e-01	0.295
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.699197e-01	0.174
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	1.914937e-01	0.718
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	1.914937e-01	0.718
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.914937e-01	0.718
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.515973e-01	0.345
Cyclin E associated events during G1/S transition	R-HSA-69202	1.650436e-01	0.782
Release of Hh-Np from the secreting cell	R-HSA-5362798	5.511397e-01	0.259
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	4.689319e-01	0.329
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	4.904429e-01	0.309
G-protein beta:gamma signalling	R-HSA-397795	5.477960e-01	0.261
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.326230e-01	0.199
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.029995e-01	0.220
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	6.676403e-01	0.175
Constitutive Signaling by EGFRvIII	R-HSA-5637810	6.461958e-01	0.190
Signaling by EGFRvIII in Cancer	R-HSA-5637812	6.461958e-01	0.190
Nephrin family interactions	R-HSA-373753	4.569638e-01	0.340
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	2.646296e-01	0.577
Regulation of KIT signaling	R-HSA-1433559	2.698581e-01	0.569
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.757111e-01	0.323
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.425207e-01	0.354
Selective autophagy	R-HSA-9663891	6.342431e-01	0.198
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	6.415408e-01	0.193
Platelet calcium homeostasis	R-HSA-418360	6.801378e-01	0.167
Signaling by NTRK3 (TRKC)	R-HSA-9034015	5.072179e-01	0.295
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	6.210503e-01	0.207
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.431386e-01	0.844
TBC/RABGAPs	R-HSA-8854214	5.781003e-01	0.238
HDMs demethylate histones	R-HSA-3214842	3.759142e-01	0.425
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.373543e-01	0.862
Formation of the anterior neural plate	R-HSA-9823739	1.255299e-01	0.901
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	1.431457e-01	0.844
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.938365e-01	0.405
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.698581e-01	0.569
Sensory perception of sour taste	R-HSA-9729555	4.515973e-01	0.345
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.566593e-01	0.805
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.998664e-01	0.699
Regulation of the apoptosome activity	R-HSA-9627069	3.737061e-01	0.427
Activation of SMO	R-HSA-5635838	3.238954e-01	0.490
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.509852e-01	0.455
Interleukin-36 pathway	R-HSA-9014826	5.038571e-01	0.298
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	4.427826e-01	0.354
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.511397e-01	0.259
RNA Polymerase I Transcription Initiation	R-HSA-73762	3.849669e-01	0.415
Retrograde neurotrophin signalling	R-HSA-177504	5.378616e-01	0.269
DNA strand elongation	R-HSA-69190	5.275297e-01	0.278
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.477960e-01	0.261
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	5.947337e-01	0.226
Ca2+ activated K+ channels	R-HSA-1296052	6.326230e-01	0.199
VLDL clearance	R-HSA-8964046	6.326230e-01	0.199
Metalloprotease DUBs	R-HSA-5689901	6.210503e-01	0.207
Signaling by FGFR3 in disease	R-HSA-5655332	6.415408e-01	0.193
TGFBR3 PTM regulation	R-HSA-9839383	6.676403e-01	0.175
Regulation of gene expression in beta cells	R-HSA-210745	6.801378e-01	0.167
Interferon Signaling	R-HSA-913531	6.126892e-01	0.213
Semaphorin interactions	R-HSA-373755	2.847661e-01	0.546
RUNX2 regulates bone development	R-HSA-8941326	4.305178e-01	0.366
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	5.223704e-01	0.282
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.034659e-01	0.692
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.486091e-01	0.604
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	5.997747e-01	0.222
Signaling by TGFBR3	R-HSA-9839373	6.279781e-01	0.202
FLT3 Signaling	R-HSA-9607240	3.498281e-01	0.456
Formation of apoptosome	R-HSA-111458	3.737061e-01	0.427
Cell-extracellular matrix interactions	R-HSA-446353	5.669719e-01	0.246
SARS-CoV-2-host interactions	R-HSA-9705683	5.938632e-01	0.226
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.582284e-01	0.588
L1CAM interactions	R-HSA-373760	6.490535e-01	0.188
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.278552e-01	0.642
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	2.698581e-01	0.569
Rap1 signalling	R-HSA-392517	4.310315e-01	0.365
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	4.110868e-01	0.386
PI3K/AKT Signaling in Cancer	R-HSA-2219528	5.607501e-01	0.251
Diseases of DNA repair	R-HSA-9675135	4.549706e-01	0.342
Specification of primordial germ cells	R-HSA-9827857	3.779460e-01	0.423
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	3.719890e-01	0.429
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.878385e-01	0.312
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	3.378577e-01	0.471
Dopamine receptors	R-HSA-390651	4.515973e-01	0.345
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	3.238954e-01	0.490
NrCAM interactions	R-HSA-447038	5.038571e-01	0.298
Cytochrome c-mediated apoptotic response	R-HSA-111461	4.427826e-01	0.354
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	5.511397e-01	0.259
Formation of axial mesoderm	R-HSA-9796292	5.074267e-01	0.295
NADPH regeneration	R-HSA-389542	5.939187e-01	0.226
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.939187e-01	0.226
Class I MHC mediated antigen processing & presentation	R-HSA-983169	6.126892e-01	0.213
Alpha-defensins	R-HSA-1462054	6.676403e-01	0.175
Sodium/Proton exchangers	R-HSA-425986	6.676403e-01	0.175
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	6.699197e-01	0.174
Signaling by NOTCH3	R-HSA-9012852	6.026261e-01	0.220
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	4.205000e-01	0.376
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	5.607065e-01	0.251
Signaling by NTRK2 (TRKB)	R-HSA-9006115	6.415408e-01	0.193
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.238954e-01	0.490
Zygotic genome activation (ZGA)	R-HSA-9819196	4.823815e-01	0.317
MITF-M-regulated melanocyte development	R-HSA-9730414	5.552187e-01	0.256
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.008939e-01	0.697
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.857346e-01	0.314
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.685590e-01	0.773
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	2.698581e-01	0.569
Intrinsic Pathway for Apoptosis	R-HSA-109606	3.134871e-01	0.504
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	6.211396e-01	0.207
Glycolysis	R-HSA-70171	1.534574e-01	0.814
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.375873e-01	0.359
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.971005e-01	0.705
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.526221e-01	0.816
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	3.086821e-01	0.510
Signaling by ALK	R-HSA-201556	3.149808e-01	0.502
Phospholipid metabolism	R-HSA-1483257	5.626751e-01	0.250
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.314171e-01	0.275
MITF-M-dependent gene expression	R-HSA-9856651	2.480989e-01	0.605
Signaling by TGFB family members	R-HSA-9006936	5.147410e-01	0.288
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.560393e-01	0.807
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.014086e-01	0.521
Uptake and function of anthrax toxins	R-HSA-5210891	3.779460e-01	0.423
HDL clearance	R-HSA-8964011	5.939187e-01	0.226
CHL1 interactions	R-HSA-447041	6.326230e-01	0.199
Interleukin-7 signaling	R-HSA-1266695	5.997747e-01	0.222
Regulation of beta-cell development	R-HSA-186712	6.608213e-01	0.180
SLC-mediated transport of inorganic anions	R-HSA-9958790	4.689319e-01	0.329
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	4.642826e-01	0.333
MAP kinase activation	R-HSA-450294	6.878308e-01	0.163
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.010453e-01	0.697
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.951213e-01	0.225
RMTs methylate histone arginines	R-HSA-3214858	5.951213e-01	0.225
Interleukin-15 signaling	R-HSA-8983432	2.170269e-01	0.663
Gene Silencing by RNA	R-HSA-211000	2.194302e-01	0.659
Interleukin-2 family signaling	R-HSA-451927	5.064988e-01	0.295
Physiological factors	R-HSA-5578768	2.698581e-01	0.569
Depolymerization of the Nuclear Lamina	R-HSA-4419969	4.046622e-01	0.393
Miscellaneous transport and binding events	R-HSA-5223345	3.719890e-01	0.429
Pyroptosis	R-HSA-5620971	6.612377e-01	0.180
ChREBP activates metabolic gene expression	R-HSA-163765	4.087377e-01	0.389
Neurodegenerative Diseases	R-HSA-8863678	3.534783e-01	0.452
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.534783e-01	0.452
Nectin/Necl trans heterodimerization	R-HSA-420597	5.038571e-01	0.298
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.205000e-01	0.376
Glucose metabolism	R-HSA-70326	3.361641e-01	0.473
Acyl chain remodelling of PS	R-HSA-1482801	5.997747e-01	0.222
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.823815e-01	0.317
Apoptotic factor-mediated response	R-HSA-111471	6.699197e-01	0.174
Signaling by Leptin	R-HSA-2586552	3.737061e-01	0.427
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.326865e-01	0.274
Interleukin-37 signaling	R-HSA-9008059	1.561895e-01	0.806
Nephron development	R-HSA-9831926	6.699197e-01	0.174
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	4.046622e-01	0.393
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	5.314171e-01	0.275
Cytoprotection by HMOX1	R-HSA-9707564	6.894656e-01	0.161
Signaling by Insulin receptor	R-HSA-74752	6.911631e-01	0.160
PI-3K cascade:FGFR3	R-HSA-5654710	6.923376e-01	0.160
Regulation of signaling by CBL	R-HSA-912631	6.923376e-01	0.160
Gastrulation	R-HSA-9758941	6.972214e-01	0.157
SHC1 events in ERBB2 signaling	R-HSA-1250196	6.982427e-01	0.156
Downstream signaling of activated FGFR4	R-HSA-5654716	6.982427e-01	0.156
DAP12 signaling	R-HSA-2424491	6.982427e-01	0.156
MAPK1 (ERK2) activation	R-HSA-112411	6.993218e-01	0.155
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.993218e-01	0.155
MASTL Facilitates Mitotic Progression	R-HSA-2465910	6.993218e-01	0.155
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.993218e-01	0.155
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	6.993218e-01	0.155
mRNA Editing	R-HSA-75072	6.993218e-01	0.155
ARMS-mediated activation	R-HSA-170984	6.993218e-01	0.155
Lipophagy	R-HSA-9613354	6.993218e-01	0.155
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.133858e-01	0.147
PI-3K cascade:FGFR4	R-HSA-5654720	7.134828e-01	0.147
Formation of definitive endoderm	R-HSA-9823730	7.134828e-01	0.147
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.134828e-01	0.147
Negative regulation of MET activity	R-HSA-6807004	7.134828e-01	0.147
Signal transduction by L1	R-HSA-445144	7.134828e-01	0.147
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.155584e-01	0.145
EGFR downregulation	R-HSA-182971	7.155584e-01	0.145
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	7.161778e-01	0.145
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	7.162906e-01	0.145
Signaling by WNT	R-HSA-195721	7.184054e-01	0.144
Activation of HOX genes during differentiation	R-HSA-5619507	7.229984e-01	0.141
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	7.229984e-01	0.141
Protein ubiquitination	R-HSA-8852135	7.235383e-01	0.141
MAPK3 (ERK1) activation	R-HSA-110056	7.279850e-01	0.138
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.279850e-01	0.138
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.279850e-01	0.138
Folding of actin by CCT/TriC	R-HSA-390450	7.279850e-01	0.138
Regulation of CDH11 function	R-HSA-9762292	7.279850e-01	0.138
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.279850e-01	0.138
EGFR Transactivation by Gastrin	R-HSA-2179392	7.279850e-01	0.138
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.279850e-01	0.138
Receptor Mediated Mitophagy	R-HSA-8934903	7.279850e-01	0.138
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.333943e-01	0.135
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.333943e-01	0.135
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.333943e-01	0.135
Signalling to RAS	R-HSA-167044	7.333943e-01	0.135
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.333943e-01	0.135
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	7.333943e-01	0.135
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	7.333943e-01	0.135
Cellular response to hypoxia	R-HSA-1234174	7.374654e-01	0.132
HCMV Early Events	R-HSA-9609690	7.375180e-01	0.132
VEGFA-VEGFR2 Pathway	R-HSA-4420097	7.418529e-01	0.130
Translation initiation complex formation	R-HSA-72649	7.421700e-01	0.129
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	7.421700e-01	0.129
Influenza Viral RNA Transcription and Replication	R-HSA-168273	7.452461e-01	0.128
Assembly of the ORC complex at the origin of replication	R-HSA-68616	7.478627e-01	0.126
Regulation of necroptotic cell death	R-HSA-5675482	7.478627e-01	0.126
Signaling by FGFR4	R-HSA-5654743	7.499057e-01	0.125
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.499057e-01	0.125
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.521151e-01	0.124
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.521151e-01	0.124
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.521151e-01	0.124
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.521151e-01	0.124
SLC transporter disorders	R-HSA-5619102	7.538304e-01	0.123
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.539173e-01	0.123
DAG1 core M3 glycosylations	R-HSA-8932505	7.539173e-01	0.123
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.539173e-01	0.123
Presynaptic depolarization and calcium channel opening	R-HSA-112308	7.539173e-01	0.123
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.539173e-01	0.123
Ionotropic activity of kainate receptors	R-HSA-451306	7.539173e-01	0.123
Activated NTRK3 signals through RAS	R-HSA-9034864	7.539173e-01	0.123
Synthesis of PI	R-HSA-1483226	7.539173e-01	0.123
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.539173e-01	0.123
Chylomicron assembly	R-HSA-8963888	7.539173e-01	0.123
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.539173e-01	0.123
PECAM1 interactions	R-HSA-210990	7.539173e-01	0.123
Suppression of apoptosis	R-HSA-9635465	7.539173e-01	0.123
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.539173e-01	0.123
Interleukin-2 signaling	R-HSA-9020558	7.539173e-01	0.123
Mitochondrial biogenesis	R-HSA-1592230	7.590274e-01	0.120
HCMV Late Events	R-HSA-9610379	7.600956e-01	0.119
Effects of PIP2 hydrolysis	R-HSA-114508	7.628791e-01	0.118
DAP12 interactions	R-HSA-2172127	7.631033e-01	0.117
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	7.661664e-01	0.116
Ribosomal scanning and start codon recognition	R-HSA-72702	7.662689e-01	0.116
ER to Golgi Anterograde Transport	R-HSA-199977	7.668652e-01	0.115
PI-3K cascade:FGFR1	R-HSA-5654689	7.696912e-01	0.114
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.696912e-01	0.114
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.696912e-01	0.114
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.696912e-01	0.114
Signaling by KIT in disease	R-HSA-9669938	7.696912e-01	0.114
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.696912e-01	0.114
Regulated Necrosis	R-HSA-5218859	7.708168e-01	0.113
Base Excision Repair	R-HSA-73884	7.724344e-01	0.112
Transcriptional regulation by RUNX2	R-HSA-8878166	7.754005e-01	0.110
Signaling by FGFR3	R-HSA-5654741	7.757520e-01	0.110
Signaling by MET	R-HSA-6806834	7.760375e-01	0.110
Signaling by NOTCH2	R-HSA-1980145	7.771610e-01	0.109
Mitophagy	R-HSA-5205647	7.771610e-01	0.109
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	7.771610e-01	0.109
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	7.771610e-01	0.109
Anchoring fibril formation	R-HSA-2214320	7.773787e-01	0.109
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	7.773787e-01	0.109
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.773787e-01	0.109
Activated NTRK2 signals through RAS	R-HSA-9026519	7.773787e-01	0.109
NF-kB is activated and signals survival	R-HSA-209560	7.773787e-01	0.109
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.773787e-01	0.109
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.773787e-01	0.109
Integration of provirus	R-HSA-162592	7.773787e-01	0.109
Pre-NOTCH Transcription and Translation	R-HSA-1912408	7.815706e-01	0.107
Regulation of PTEN mRNA translation	R-HSA-8943723	7.861705e-01	0.104
Formation of the ureteric bud	R-HSA-9830674	7.861705e-01	0.104
Carnitine shuttle	R-HSA-200425	7.861705e-01	0.104
Free fatty acids regulate insulin secretion	R-HSA-400451	7.861705e-01	0.104
Growth hormone receptor signaling	R-HSA-982772	7.861705e-01	0.104
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	7.907275e-01	0.102
Downstream signaling of activated FGFR2	R-HSA-5654696	7.907275e-01	0.102
Downstream signaling of activated FGFR1	R-HSA-5654687	7.907275e-01	0.102
Interleukin-17 signaling	R-HSA-448424	7.912294e-01	0.102
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	7.948488e-01	0.100
Macroautophagy	R-HSA-1632852	7.957782e-01	0.099
IRAK1 recruits IKK complex	R-HSA-937039	7.986046e-01	0.098
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	7.986046e-01	0.098
GRB2 events in EGFR signaling	R-HSA-179812	7.986046e-01	0.098
RUNX3 regulates p14-ARF	R-HSA-8951936	7.986046e-01	0.098
Polymerase switching	R-HSA-69091	7.986046e-01	0.098
Leading Strand Synthesis	R-HSA-69109	7.986046e-01	0.098
Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77285	7.986046e-01	0.098
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	7.986046e-01	0.098
MET activates RAS signaling	R-HSA-8851805	7.986046e-01	0.098
SHC-related events triggered by IGF1R	R-HSA-2428933	7.986046e-01	0.098
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.986046e-01	0.098
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.986046e-01	0.098
OAS antiviral response	R-HSA-8983711	7.986046e-01	0.098
Estrogen biosynthesis	R-HSA-193144	7.986046e-01	0.098
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.986046e-01	0.098
Extension of Telomeres	R-HSA-180786	7.991523e-01	0.097
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.994422e-01	0.097
Recycling pathway of L1	R-HSA-437239	7.994422e-01	0.097
NoRC negatively regulates rRNA expression	R-HSA-427413	8.009000e-01	0.096
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	8.016026e-01	0.096
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.016026e-01	0.096
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.016026e-01	0.096
CD209 (DC-SIGN) signaling	R-HSA-5621575	8.016026e-01	0.096
Plasma lipoprotein assembly	R-HSA-8963898	8.016026e-01	0.096
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	8.016026e-01	0.096
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.035995e-01	0.095
RNA Polymerase III Transcription	R-HSA-74158	8.035995e-01	0.095
Regulation of TP53 Degradation	R-HSA-6804757	8.035995e-01	0.095
Calmodulin induced events	R-HSA-111933	8.035995e-01	0.095
CaM pathway	R-HSA-111997	8.035995e-01	0.095
Maternal to zygotic transition (MZT)	R-HSA-9816359	8.057518e-01	0.094
DNA Replication	R-HSA-69306	8.081993e-01	0.092
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.102201e-01	0.091
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.102201e-01	0.091
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.157989e-01	0.088
TRAF6 mediated IRF7 activation	R-HSA-933541	8.157989e-01	0.088
Collagen chain trimerization	R-HSA-8948216	8.157989e-01	0.088
PI-3K cascade:FGFR2	R-HSA-5654695	8.160371e-01	0.088
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.160371e-01	0.088
Tight junction interactions	R-HSA-420029	8.160371e-01	0.088
Adenylate cyclase activating pathway	R-HSA-170660	8.178079e-01	0.087
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	8.178079e-01	0.087
Chylomicron remodeling	R-HSA-8963901	8.178079e-01	0.087
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.178079e-01	0.087
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.178079e-01	0.087
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.178079e-01	0.087
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.178079e-01	0.087
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.178079e-01	0.087
PLC beta mediated events	R-HSA-112043	8.189730e-01	0.087
Ca2+ pathway	R-HSA-4086398	8.191951e-01	0.087
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	8.225764e-01	0.085
Signaling by VEGF	R-HSA-194138	8.264524e-01	0.083
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.273485e-01	0.082
Signaling by PDGF	R-HSA-186797	8.282768e-01	0.082
Interferon alpha/beta signaling	R-HSA-909733	8.294727e-01	0.081
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.295240e-01	0.081
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.295240e-01	0.081
Signaling by EGFR in Cancer	R-HSA-1643713	8.295240e-01	0.081
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.295240e-01	0.081
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.295240e-01	0.081
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.295240e-01	0.081
TRP channels	R-HSA-3295583	8.295240e-01	0.081
Regulation of RAS by GAPs	R-HSA-5658442	8.311357e-01	0.080
Signaling by FGFR2 in disease	R-HSA-5655253	8.311357e-01	0.080
cGMP effects	R-HSA-418457	8.351811e-01	0.078
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.351811e-01	0.078
CRMPs in Sema3A signaling	R-HSA-399956	8.351811e-01	0.078
Synthesis of IPs in the nucleus	R-HSA-1855191	8.351811e-01	0.078
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77310	8.351811e-01	0.078
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77350	8.351811e-01	0.078
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77348	8.351811e-01	0.078
Malate-aspartate shuttle	R-HSA-9856872	8.351811e-01	0.078
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.351811e-01	0.078
HDL assembly	R-HSA-8963896	8.351811e-01	0.078
Signal regulatory protein family interactions	R-HSA-391160	8.351811e-01	0.078
Acyl chain remodeling of CL	R-HSA-1482798	8.351811e-01	0.078
P2Y receptors	R-HSA-417957	8.351811e-01	0.078
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.351811e-01	0.078
Influenza Infection	R-HSA-168255	8.356365e-01	0.078
rRNA modification in the nucleus and cytosol	R-HSA-6790901	8.371883e-01	0.077
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.407285e-01	0.075
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	8.421126e-01	0.075
Maturation of hRSV A proteins	R-HSA-9828806	8.421126e-01	0.075
tRNA processing	R-HSA-72306	8.476174e-01	0.072
Formation of Incision Complex in GG-NER	R-HSA-5696395	8.485931e-01	0.071
Nuclear signaling by ERBB4	R-HSA-1251985	8.485931e-01	0.071
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.508986e-01	0.070
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	8.508986e-01	0.070
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.508986e-01	0.070
G beta:gamma signalling through BTK	R-HSA-8964315	8.508986e-01	0.070
SHC1 events in EGFR signaling	R-HSA-180336	8.508986e-01	0.070
p38MAPK events	R-HSA-171007	8.508986e-01	0.070
Transport and metabolism of PAPS	R-HSA-174362	8.508986e-01	0.070
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	8.508986e-01	0.070
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	8.508986e-01	0.070
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.508986e-01	0.070
Lysosphingolipid and LPA receptors	R-HSA-419408	8.508986e-01	0.070
Spry regulation of FGF signaling	R-HSA-1295596	8.508986e-01	0.070
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	8.508986e-01	0.070
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	8.508986e-01	0.070
DCC mediated attractive signaling	R-HSA-418885	8.508986e-01	0.070
DNA Damage Reversal	R-HSA-73942	8.508986e-01	0.070
Diseases of programmed cell death	R-HSA-9645723	8.512945e-01	0.070
MyD88 cascade initiated on plasma membrane	R-HSA-975871	8.518861e-01	0.070
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	8.518861e-01	0.070
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	8.518861e-01	0.070
Activation of AMPK downstream of NMDARs	R-HSA-9619483	8.538517e-01	0.069
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.538517e-01	0.069
Phase 0 - rapid depolarisation	R-HSA-5576892	8.538517e-01	0.069
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.538517e-01	0.069
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.538517e-01	0.069
Vesicle-mediated transport	R-HSA-5653656	8.582219e-01	0.066
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.583360e-01	0.066
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.583360e-01	0.066
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.583360e-01	0.066
Regulation of PTEN stability and activity	R-HSA-8948751	8.585427e-01	0.066
Smooth Muscle Contraction	R-HSA-445355	8.585427e-01	0.066
Termination of translesion DNA synthesis	R-HSA-5656169	8.647887e-01	0.063
DARPP-32 events	R-HSA-180024	8.647887e-01	0.063
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.647887e-01	0.063
Class I peroxisomal membrane protein import	R-HSA-9603798	8.651181e-01	0.063
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	8.651181e-01	0.063
Induction of Cell-Cell Fusion	R-HSA-9733458	8.651181e-01	0.063
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.651181e-01	0.063
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.651181e-01	0.063
Negative regulation of FLT3	R-HSA-9706369	8.651181e-01	0.063
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.667939e-01	0.062
G-protein mediated events	R-HSA-112040	8.691086e-01	0.061
PKR-mediated signaling	R-HSA-9833482	8.729162e-01	0.059
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.749698e-01	0.058
Cleavage of the damaged pyrimidine	R-HSA-110329	8.761839e-01	0.057
Depyrimidination	R-HSA-73928	8.761839e-01	0.057
Ca-dependent events	R-HSA-111996	8.761839e-01	0.057
MHC class II antigen presentation	R-HSA-2132295	8.774300e-01	0.057
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.779823e-01	0.057
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	8.779823e-01	0.057
SHC1 events in ERBB4 signaling	R-HSA-1250347	8.779823e-01	0.057
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	R-HSA-77288	8.779823e-01	0.057
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	8.779823e-01	0.057
Fibronectin matrix formation	R-HSA-1566977	8.779823e-01	0.057
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77346	8.779823e-01	0.057
Scavenging by Class B Receptors	R-HSA-3000471	8.779823e-01	0.057
Synthesis of PG	R-HSA-1483148	8.779823e-01	0.057
tRNA modification in the mitochondrion	R-HSA-6787450	8.779823e-01	0.057
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.820610e-01	0.055
Signaling by FGFR1	R-HSA-5654736	8.820610e-01	0.055
Defective pyroptosis	R-HSA-9710421	8.843367e-01	0.053
Budding and maturation of HIV virion	R-HSA-162588	8.844397e-01	0.053
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.844397e-01	0.053
Autophagy	R-HSA-9612973	8.860780e-01	0.053
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	8.877719e-01	0.052
PI3K events in ERBB2 signaling	R-HSA-1963642	8.896202e-01	0.051
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	8.896202e-01	0.051
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.896202e-01	0.051
Regulation of NPAS4 gene expression	R-HSA-9768759	8.896202e-01	0.051
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.896202e-01	0.051
EPHB-mediated forward signaling	R-HSA-3928662	8.920070e-01	0.050
Amine ligand-binding receptors	R-HSA-375280	8.920070e-01	0.050
Netrin-1 signaling	R-HSA-373752	8.920070e-01	0.050
TP53 Regulates Metabolic Genes	R-HSA-5628897	8.923443e-01	0.049
RSV-host interactions	R-HSA-9833110	8.929874e-01	0.049
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.932413e-01	0.049
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	8.932413e-01	0.049
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	8.944766e-01	0.048
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	8.952066e-01	0.048
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.955733e-01	0.048
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	8.955733e-01	0.048
Hedgehog 'on' state	R-HSA-5632684	8.955733e-01	0.048
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.957827e-01	0.048
ESR-mediated signaling	R-HSA-8939211	8.959335e-01	0.048
Fanconi Anemia Pathway	R-HSA-6783310	8.992179e-01	0.046
DAG and IP3 signaling	R-HSA-1489509	8.992179e-01	0.046
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.996855e-01	0.046
GAB1 signalosome	R-HSA-180292	9.001488e-01	0.046
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	9.001488e-01	0.046
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.001488e-01	0.046
Synaptic adhesion-like molecules	R-HSA-8849932	9.001488e-01	0.046
RNA Polymerase III Transcription Termination	R-HSA-73980	9.001488e-01	0.046
PKA activation in glucagon signalling	R-HSA-164378	9.001488e-01	0.046
PKA activation	R-HSA-163615	9.001488e-01	0.046
Tie2 Signaling	R-HSA-210993	9.001488e-01	0.046
Platelet sensitization by LDL	R-HSA-432142	9.001488e-01	0.046
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.001488e-01	0.046
HCMV Infection	R-HSA-9609646	9.013853e-01	0.045
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.014160e-01	0.045
Negative regulation of FGFR1 signaling	R-HSA-5654726	9.014160e-01	0.045
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.015001e-01	0.045
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.021019e-01	0.045
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.059917e-01	0.043
Striated Muscle Contraction	R-HSA-390522	9.090033e-01	0.041
Translesion Synthesis by POLH	R-HSA-110320	9.096736e-01	0.041
Signaling by FGFR2 IIIa TM	R-HSA-8851708	9.096736e-01	0.041
Specification of the neural plate border	R-HSA-9834899	9.096736e-01	0.041
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	9.096736e-01	0.041
Methionine salvage pathway	R-HSA-1237112	9.096736e-01	0.041
HDL remodeling	R-HSA-8964058	9.096736e-01	0.041
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.096736e-01	0.041
The NLRP3 inflammasome	R-HSA-844456	9.096736e-01	0.041
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.096736e-01	0.041
Potential therapeutics for SARS	R-HSA-9679191	9.097929e-01	0.041
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.118600e-01	0.040
Signaling by NOTCH4	R-HSA-9013694	9.122591e-01	0.040
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.123507e-01	0.040
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.134700e-01	0.039
Leishmania phagocytosis	R-HSA-9664417	9.134700e-01	0.039
Parasite infection	R-HSA-9664407	9.134700e-01	0.039
Collagen degradation	R-HSA-1442490	9.137318e-01	0.039
Formation of paraxial mesoderm	R-HSA-9793380	9.137318e-01	0.039
Telomere Maintenance	R-HSA-157579	9.140183e-01	0.039
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	9.146481e-01	0.039
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	9.146481e-01	0.039
Dual Incision in GG-NER	R-HSA-5696400	9.160407e-01	0.038
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.160407e-01	0.038
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.161086e-01	0.038
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.170908e-01	0.038
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.172763e-01	0.037
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.182904e-01	0.037
VxPx cargo-targeting to cilium	R-HSA-5620916	9.182904e-01	0.037
Acyl chain remodelling of PI	R-HSA-1482922	9.182904e-01	0.037
Co-stimulation by CD28	R-HSA-389356	9.183160e-01	0.037
Regulation of Apoptosis	R-HSA-169911	9.225641e-01	0.035
Gap junction trafficking and regulation	R-HSA-157858	9.239085e-01	0.034
p53-Dependent G1 DNA Damage Response	R-HSA-69563	9.239085e-01	0.034
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	9.239085e-01	0.034
G1/S DNA Damage Checkpoints	R-HSA-69615	9.241129e-01	0.034
Signaling by PTK6	R-HSA-8848021	9.241129e-01	0.034
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	9.241129e-01	0.034
SARS-CoV-2 Infection	R-HSA-9694516	9.243411e-01	0.034
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	9.260450e-01	0.033
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	9.260450e-01	0.033
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.260857e-01	0.033
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.260857e-01	0.033
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	9.260857e-01	0.033
Lagging Strand Synthesis	R-HSA-69186	9.260857e-01	0.033
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.260857e-01	0.033
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.260857e-01	0.033
Basigin interactions	R-HSA-210991	9.260857e-01	0.033
Early Phase of HIV Life Cycle	R-HSA-162594	9.260857e-01	0.033
HSF1 activation	R-HSA-3371511	9.286076e-01	0.032
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.286076e-01	0.032
Triglyceride catabolism	R-HSA-163560	9.286076e-01	0.032
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.313891e-01	0.031
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.313891e-01	0.031
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	9.331376e-01	0.030
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	9.331376e-01	0.030
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.331376e-01	0.030
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	9.331376e-01	0.030
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	9.331376e-01	0.030
Molybdenum cofactor biosynthesis	R-HSA-947581	9.331376e-01	0.030
Degradation of AXIN	R-HSA-4641257	9.342032e-01	0.030
Voltage gated Potassium channels	R-HSA-1296072	9.342032e-01	0.030
Cleavage of the damaged purine	R-HSA-110331	9.342032e-01	0.030
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.386448e-01	0.027
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.386448e-01	0.027
Uptake and actions of bacterial toxins	R-HSA-5339562	9.386448e-01	0.027
Signaling by FGFR2	R-HSA-5654738	9.387438e-01	0.027
Depurination	R-HSA-73927	9.393815e-01	0.027
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.395172e-01	0.027
FGFR2 alternative splicing	R-HSA-6803529	9.395172e-01	0.027
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	9.395172e-01	0.027
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.395172e-01	0.027
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.395172e-01	0.027
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.395172e-01	0.027
LDL clearance	R-HSA-8964038	9.395172e-01	0.027
Opioid Signalling	R-HSA-111885	9.407612e-01	0.027
Kidney development	R-HSA-9830369	9.415680e-01	0.026
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.422732e-01	0.026
RAF/MAP kinase cascade	R-HSA-5673001	9.426625e-01	0.026
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.441710e-01	0.025
Stabilization of p53	R-HSA-69541	9.441710e-01	0.025
Plasma lipoprotein clearance	R-HSA-8964043	9.441710e-01	0.025
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.441710e-01	0.025
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.452884e-01	0.024
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.452884e-01	0.024
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.452884e-01	0.024
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	9.452884e-01	0.024
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.452884e-01	0.024
ABC transporters in lipid homeostasis	R-HSA-1369062	9.452884e-01	0.024
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.453180e-01	0.024
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	9.469090e-01	0.024
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.482653e-01	0.023
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.485988e-01	0.023
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.485988e-01	0.023
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.485988e-01	0.023
Diseases of Immune System	R-HSA-5260271	9.485988e-01	0.023
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	9.505092e-01	0.022
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.505092e-01	0.022
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.505092e-01	0.022
TNFs bind their physiological receptors	R-HSA-5669034	9.505092e-01	0.022
G alpha (z) signalling events	R-HSA-418597	9.507009e-01	0.022
Interleukin-1 family signaling	R-HSA-446652	9.521325e-01	0.021
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	9.521588e-01	0.021
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.521650e-01	0.021
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	9.521650e-01	0.021
VEGFR2 mediated vascular permeability	R-HSA-5218920	9.526903e-01	0.021
Maturation of spike protein	R-HSA-9694548	9.526903e-01	0.021
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.534063e-01	0.021
Polymerase switching on the C-strand of the telomere	R-HSA-174411	9.552321e-01	0.020
Long-term potentiation	R-HSA-9620244	9.552321e-01	0.020
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.552321e-01	0.020
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.552321e-01	0.020
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.552321e-01	0.020
Laminin interactions	R-HSA-3000157	9.552321e-01	0.020
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.552321e-01	0.020
MAPK1/MAPK3 signaling	R-HSA-5684996	9.552476e-01	0.020
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.564694e-01	0.019
Degradation of CRY and PER proteins	R-HSA-9932298	9.564694e-01	0.019
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.564694e-01	0.019
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.564694e-01	0.019
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	9.564694e-01	0.019
Synthesis of PA	R-HSA-1483166	9.574689e-01	0.019
Developmental Lineages of the Mammary Gland	R-HSA-9924644	9.582151e-01	0.019
Suppression of phagosomal maturation	R-HSA-9637687	9.595045e-01	0.018
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.595045e-01	0.018
Urea cycle	R-HSA-70635	9.595045e-01	0.018
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	9.598601e-01	0.018
MyD88-independent TLR4 cascade	R-HSA-166166	9.598601e-01	0.018
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.599583e-01	0.018
Chaperonin-mediated protein folding	R-HSA-390466	9.628457e-01	0.016
Response of Mtb to phagocytosis	R-HSA-9637690	9.631781e-01	0.016
Amino acid transport across the plasma membrane	R-HSA-352230	9.633581e-01	0.016
Triglyceride metabolism	R-HSA-8979227	9.633581e-01	0.016
RNA Polymerase I Transcription Termination	R-HSA-73863	9.633695e-01	0.016
Packaging Of Telomere Ends	R-HSA-171306	9.633695e-01	0.016
CD28 dependent PI3K/Akt signaling	R-HSA-389357	9.633695e-01	0.016
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.633695e-01	0.016
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.633695e-01	0.016
Cristae formation	R-HSA-8949613	9.633695e-01	0.016
RNA Polymerase I Promoter Opening	R-HSA-73728	9.633695e-01	0.016
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	9.633695e-01	0.016
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.633695e-01	0.016
Triglyceride biosynthesis	R-HSA-75109	9.633695e-01	0.016
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.633695e-01	0.016
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.633695e-01	0.016
Signaling by ERBB4	R-HSA-1236394	9.635507e-01	0.016
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.641868e-01	0.016
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.641868e-01	0.016
Interferon gamma signaling	R-HSA-877300	9.658636e-01	0.015
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.659744e-01	0.015
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.660063e-01	0.015
Proteasome assembly	R-HSA-9907900	9.661482e-01	0.015
Surfactant metabolism	R-HSA-5683826	9.661482e-01	0.015
Gap junction trafficking	R-HSA-190828	9.661482e-01	0.015
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.668657e-01	0.015
Pyrimidine salvage	R-HSA-73614	9.668657e-01	0.015
Inflammasomes	R-HSA-622312	9.668657e-01	0.015
Signaling by Nuclear Receptors	R-HSA-9006931	9.669208e-01	0.015
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.679901e-01	0.014
Neddylation	R-HSA-8951664	9.683328e-01	0.014
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.684732e-01	0.014
Beta-catenin independent WNT signaling	R-HSA-3858494	9.688468e-01	0.014
Integration of energy metabolism	R-HSA-163685	9.688468e-01	0.014
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.688871e-01	0.014
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.688871e-01	0.014
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.688871e-01	0.014
Asymmetric localization of PCP proteins	R-HSA-4608870	9.688871e-01	0.014
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.700285e-01	0.013
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.700285e-01	0.013
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.700285e-01	0.013
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.700285e-01	0.013
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.700285e-01	0.013
Disorders of transmembrane transporters	R-HSA-5619115	9.703678e-01	0.013
Regulation of pyruvate metabolism	R-HSA-9861718	9.714118e-01	0.013
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	9.728895e-01	0.012
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.737382e-01	0.012
Synthesis of PC	R-HSA-1483191	9.737382e-01	0.012
Transport to the Golgi and subsequent modification	R-HSA-948021	9.744902e-01	0.011
MAPK family signaling cascades	R-HSA-5683057	9.747239e-01	0.011
Cap-dependent Translation Initiation	R-HSA-72737	9.747452e-01	0.011
Eukaryotic Translation Initiation	R-HSA-72613	9.747452e-01	0.011
Protein folding	R-HSA-391251	9.748185e-01	0.011
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.748185e-01	0.011
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.754776e-01	0.011
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.754776e-01	0.011
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.754776e-01	0.011
Cargo concentration in the ER	R-HSA-5694530	9.754776e-01	0.011
Molecules associated with elastic fibres	R-HSA-2129379	9.754776e-01	0.011
Glycerophospholipid biosynthesis	R-HSA-1483206	9.756517e-01	0.011
Plasma lipoprotein remodeling	R-HSA-8963899	9.758811e-01	0.011
Metal ion SLC transporters	R-HSA-425410	9.758811e-01	0.011
Signaling by NOTCH	R-HSA-157118	9.763218e-01	0.010
Toll-like Receptor Cascades	R-HSA-168898	9.763841e-01	0.010
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.764245e-01	0.010
SARS-CoV-1-host interactions	R-HSA-9692914	9.774883e-01	0.010
DAG1 glycosylations	R-HSA-8931838	9.778187e-01	0.010
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.778187e-01	0.010
Degradation of CDH1	R-HSA-9766229	9.778544e-01	0.010
PPARA activates gene expression	R-HSA-1989781	9.783902e-01	0.009
Azathioprine ADME	R-HSA-9748787	9.796709e-01	0.009
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	9.799365e-01	0.009
Recycling of bile acids and salts	R-HSA-159418	9.799365e-01	0.009
Integrin signaling	R-HSA-354192	9.799365e-01	0.009
SLC-mediated transport of amino acids	R-HSA-9958863	9.800642e-01	0.009
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.801494e-01	0.009
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.801494e-01	0.009
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.801494e-01	0.009
Stimuli-sensing channels	R-HSA-2672351	9.801494e-01	0.009
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.805785e-01	0.009
Meiotic recombination	R-HSA-912446	9.813426e-01	0.008
Cytosolic sulfonation of small molecules	R-HSA-156584	9.813426e-01	0.008
Hedgehog ligand biogenesis	R-HSA-5358346	9.813426e-01	0.008
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.815485e-01	0.008
Glucagon signaling in metabolic regulation	R-HSA-163359	9.818522e-01	0.008
Vpu mediated degradation of CD4	R-HSA-180534	9.818522e-01	0.008
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.818522e-01	0.008
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.818522e-01	0.008
Heme degradation	R-HSA-189483	9.818522e-01	0.008
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.819399e-01	0.008
SARS-CoV Infections	R-HSA-9679506	9.824962e-01	0.008
RNA Polymerase I Promoter Escape	R-HSA-73772	9.828805e-01	0.007
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.828805e-01	0.007
MAPK6/MAPK4 signaling	R-HSA-5687128	9.831897e-01	0.007
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.835850e-01	0.007
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.835850e-01	0.007
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.835850e-01	0.007
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.835850e-01	0.007
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.835850e-01	0.007
Calnexin/calreticulin cycle	R-HSA-901042	9.835850e-01	0.007
Hyaluronan metabolism	R-HSA-2142845	9.835850e-01	0.007
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.835850e-01	0.007
NOD1/2 Signaling Pathway	R-HSA-168638	9.835850e-01	0.007
NPAS4 regulates expression of target genes	R-HSA-9768919	9.835850e-01	0.007
COPII-mediated vesicle transport	R-HSA-204005	9.842064e-01	0.007
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.842064e-01	0.007
Signaling by FGFR	R-HSA-190236	9.842193e-01	0.007
Regulation of insulin secretion	R-HSA-422356	9.842193e-01	0.007
Meiotic synapsis	R-HSA-1221632	9.842949e-01	0.007
Amino acids regulate mTORC1	R-HSA-9639288	9.842949e-01	0.007
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.851525e-01	0.006
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.851525e-01	0.006
PERK regulates gene expression	R-HSA-381042	9.851525e-01	0.006
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	9.851525e-01	0.006
XBP1(S) activates chaperone genes	R-HSA-381038	9.854507e-01	0.006
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.855885e-01	0.006
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.855955e-01	0.006
Developmental Biology	R-HSA-1266738	9.863095e-01	0.006
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.865704e-01	0.006
Lysosome Vesicle Biogenesis	R-HSA-432720	9.865704e-01	0.006
GPVI-mediated activation cascade	R-HSA-114604	9.865704e-01	0.006
FGFR2 mutant receptor activation	R-HSA-1839126	9.865704e-01	0.006
Interleukin-1 signaling	R-HSA-9020702	9.871364e-01	0.006
Cytokine Signaling in Immune system	R-HSA-1280215	9.877110e-01	0.005
Degradation of DVL	R-HSA-4641258	9.878530e-01	0.005
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.878530e-01	0.005
SLC-mediated transport of organic cations	R-HSA-549127	9.878530e-01	0.005
Metabolism of folate and pterines	R-HSA-196757	9.878530e-01	0.005
Ion homeostasis	R-HSA-5578775	9.878895e-01	0.005
ER-Phagosome pathway	R-HSA-1236974	9.883080e-01	0.005
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.888784e-01	0.005
Regulation of CDH1 Function	R-HSA-9764561	9.888988e-01	0.005
Elastic fibre formation	R-HSA-1566948	9.890132e-01	0.005
Neurotransmitter release cycle	R-HSA-112310	9.891353e-01	0.005
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.893413e-01	0.005
Dual incision in TC-NER	R-HSA-6782135	9.898259e-01	0.004
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.900626e-01	0.004
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.900626e-01	0.004
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.900626e-01	0.004
IRE1alpha activates chaperones	R-HSA-381070	9.906252e-01	0.004
Generation of second messenger molecules	R-HSA-202433	9.910118e-01	0.004
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.910118e-01	0.004
Glycogen metabolism	R-HSA-8982491	9.910118e-01	0.004
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.910374e-01	0.004
Cardiac conduction	R-HSA-5576891	9.910943e-01	0.004
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.914448e-01	0.004
Signaling by Retinoic Acid	R-HSA-5362517	9.914588e-01	0.004
Platelet homeostasis	R-HSA-418346	9.915106e-01	0.004
PCP/CE pathway	R-HSA-4086400	9.916049e-01	0.004
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.918704e-01	0.004
Hh mutants are degraded by ERAD	R-HSA-5362768	9.918704e-01	0.004
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.918704e-01	0.004
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.918704e-01	0.004
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.921585e-01	0.003
Muscle contraction	R-HSA-397014	9.922148e-01	0.003
Co-inhibition by PD-1	R-HSA-389948	9.923624e-01	0.003
Collagen formation	R-HSA-1474290	9.924992e-01	0.003
Antigen processing-Cross presentation	R-HSA-1236975	9.926230e-01	0.003
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.926470e-01	0.003
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.926470e-01	0.003
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.926470e-01	0.003
NCAM signaling for neurite out-growth	R-HSA-375165	9.928346e-01	0.003
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.928346e-01	0.003
Mitochondrial protein import	R-HSA-1268020	9.928346e-01	0.003
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.928479e-01	0.003
SARS-CoV-1 Infection	R-HSA-9678108	9.932704e-01	0.003
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	9.933495e-01	0.003
Activation of GABAB receptors	R-HSA-991365	9.933495e-01	0.003
GABA B receptor activation	R-HSA-977444	9.933495e-01	0.003
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.933495e-01	0.003
Cytosolic tRNA aminoacylation	R-HSA-379716	9.933495e-01	0.003
Formation of a pool of free 40S subunits	R-HSA-72689	9.935428e-01	0.003
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.935428e-01	0.003
Defensins	R-HSA-1461973	9.939849e-01	0.003
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.939849e-01	0.003
Pyrimidine catabolism	R-HSA-73621	9.939849e-01	0.003
Ion transport by P-type ATPases	R-HSA-936837	9.939926e-01	0.003
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.939926e-01	0.003
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.944659e-01	0.002
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.945007e-01	0.002
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.945597e-01	0.002
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.945597e-01	0.002
Signaling by Hedgehog	R-HSA-5358351	9.946755e-01	0.002
Cellular responses to stress	R-HSA-2262752	9.949243e-01	0.002
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.949666e-01	0.002
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	9.950795e-01	0.002
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.950795e-01	0.002
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.950795e-01	0.002
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.950795e-01	0.002
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.950795e-01	0.002
Somitogenesis	R-HSA-9824272	9.950795e-01	0.002
Platelet Aggregation (Plug Formation)	R-HSA-76009	9.950795e-01	0.002
Meiosis	R-HSA-1500620	9.952258e-01	0.002
Platelet degranulation	R-HSA-114608	9.953470e-01	0.002
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.955497e-01	0.002
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.955497e-01	0.002
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.955497e-01	0.002
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.955497e-01	0.002
ABC-family proteins mediated transport	R-HSA-382556	9.955766e-01	0.002
Hedgehog 'off' state	R-HSA-5610787	9.955766e-01	0.002
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.955991e-01	0.002
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.959750e-01	0.002
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	9.961440e-01	0.002
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	9.962032e-01	0.002
Post NMDA receptor activation events	R-HSA-438064	9.962625e-01	0.002
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.962811e-01	0.002
Intraflagellar transport	R-HSA-5620924	9.963597e-01	0.002
GPER1 signaling	R-HSA-9634597	9.963597e-01	0.002
Signaling by Interleukins	R-HSA-449147	9.963942e-01	0.002
Reproduction	R-HSA-1474165	9.964674e-01	0.002
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.967076e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.967076e-01	0.001
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.967436e-01	0.001
Response of endothelial cells to shear stress	R-HSA-9860931	9.967436e-01	0.001
Adaptive Immune System	R-HSA-1280218	9.968546e-01	0.001
Regulation of T cell activation by CD28 family	R-HSA-388841	9.968809e-01	0.001
Complex IV assembly	R-HSA-9864848	9.973069e-01	0.001
Activation of NF-kappaB in B cells	R-HSA-1169091	9.973069e-01	0.001
The phototransduction cascade	R-HSA-2514856	9.973069e-01	0.001
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.974969e-01	0.001
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.975235e-01	0.001
Eukaryotic Translation Elongation	R-HSA-156842	9.977204e-01	0.001
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.977204e-01	0.001
Nucleotide biosynthesis	R-HSA-8956320	9.977972e-01	0.001
Interleukin-12 signaling	R-HSA-9020591	9.979390e-01	0.001
Translation of Structural Proteins	R-HSA-9694635	9.981163e-01	0.001
Protein localization	R-HSA-9609507	9.981703e-01	0.001
Paracetamol ADME	R-HSA-9753281	9.981983e-01	0.001
ABC transporter disorders	R-HSA-5619084	9.982786e-01	0.001
SLC-mediated transport of organic anions	R-HSA-9955298	9.982786e-01	0.001
Cholesterol biosynthesis	R-HSA-191273	9.982786e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.982786e-01	0.001
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.983706e-01	0.001
Potassium Channels	R-HSA-1296071	9.984969e-01	0.001
Cellular responses to mechanical stimuli	R-HSA-9855142	9.986186e-01	0.001
Amyloid fiber formation	R-HSA-977225	9.986873e-01	0.001
rRNA processing	R-HSA-72312	9.988402e-01	0.001
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.989048e-01	0.000
GABA receptor activation	R-HSA-977443	9.989100e-01	0.000
Metabolism of polyamines	R-HSA-351202	9.989100e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.989100e-01	0.000
Endogenous sterols	R-HSA-211976	9.990143e-01	0.000
Aquaporin-mediated transport	R-HSA-445717	9.990143e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.990143e-01	0.000
Cellular response to chemical stress	R-HSA-9711123	9.992602e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.993050e-01	0.000
Interleukin-12 family signaling	R-HSA-447115	9.993050e-01	0.000
Peptide chain elongation	R-HSA-156902	9.993657e-01	0.000
Ribosome-associated quality control	R-HSA-9948299	9.994446e-01	0.000
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.994549e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.994608e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.994608e-01	0.000
Downstream TCR signaling	R-HSA-202424	9.994716e-01	0.000
Unfolded Protein Response (UPR)	R-HSA-381119	9.994858e-01	0.000
C-type lectin receptors (CLRs)	R-HSA-5621481	9.995149e-01	0.000
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.995178e-01	0.000
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.995337e-01	0.000
TCR signaling	R-HSA-202403	9.995782e-01	0.000
Cellular responses to stimuli	R-HSA-8953897	9.995783e-01	0.000
Ion channel transport	R-HSA-983712	9.995809e-01	0.000
Cellular response to starvation	R-HSA-9711097	9.995921e-01	0.000
Neuronal System	R-HSA-112316	9.996149e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.996394e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.996394e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.996394e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.996394e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.996394e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.996447e-01	0.000
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.996953e-01	0.000
Eukaryotic Translation Termination	R-HSA-72764	9.997221e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.997334e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.997466e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.997589e-01	0.000
Iron uptake and transport	R-HSA-917937	9.997589e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.997651e-01	0.000
Post-translational protein phosphorylation	R-HSA-8957275	9.997893e-01	0.000
Integrin cell surface interactions	R-HSA-216083	9.998217e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.998388e-01	0.000
Selenocysteine synthesis	R-HSA-2408557	9.998403e-01	0.000
Extra-nuclear estrogen signaling	R-HSA-9009391	9.998403e-01	0.000
Leishmania infection	R-HSA-9658195	9.998611e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.998611e-01	0.000
Viral mRNA Translation	R-HSA-192823	9.998673e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.998682e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.998944e-01	0.000
Platelet activation, signaling and aggregation	R-HSA-76002	9.999173e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999280e-01	0.000
Transmission across Chemical Synapses	R-HSA-112315	9.999362e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999425e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999477e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999518e-01	0.000
Viral Infection Pathways	R-HSA-9824446	9.999574e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999605e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999672e-01	0.000
FCGR activation	R-HSA-2029481	9.999678e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999737e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999813e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999841e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999894e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999920e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999932e-01	0.000
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.999938e-01	0.000
Developmental Cell Lineages	R-HSA-9734767	9.999939e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999943e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999953e-01	0.000
Neutrophil degranulation	R-HSA-6798695	9.999965e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.999979e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999981e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999987e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999989e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999992e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999992e-01	0.000
Hemostasis	R-HSA-109582	9.999995e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999996e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999996e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999998e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999998e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999999e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999999e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.999999e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999999e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999999e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999999e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999999e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000
Translation	R-HSA-72766	1.000000e+00	0.000
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000
Immune System	R-HSA-168256	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Innate Immune System	R-HSA-168249	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	4.884981e-15	14.311
mRNA Splicing - Major Pathway	R-HSA-72163	3.459455e-13	12.461
mRNA Splicing	R-HSA-72172	2.137068e-12	11.670
Metabolism of RNA	R-HSA-8953854	2.289253e-10	9.640
mRNA 3'-end processing	R-HSA-72187	3.202747e-08	7.494
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	8.858475e-08	7.053
RNA Polymerase II Transcription Termination	R-HSA-73856	2.871664e-07	6.542
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.184564e-06	5.497
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.981855e-06	5.223
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.336148e-05	4.874
Apoptotic execution phase	R-HSA-75153	1.380639e-05	4.860
SWI/SNF chromatin remodelers	R-HSA-9932451	2.196478e-05	4.658
ATP-dependent chromatin remodelers	R-HSA-9932444	2.196478e-05	4.658
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	6.208644e-05	4.207
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.079882e-04	3.967
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.640719e-04	3.785
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.735114e-04	3.761
Cell Cycle	R-HSA-1640170	1.765824e-04	3.753
Chromatin organization	R-HSA-4839726	2.070715e-04	3.684
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.227808e-04	3.491
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	6.634610e-04	3.178
rRNA processing in the nucleus and cytosol	R-HSA-8868773	7.230346e-04	3.141
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	9.075771e-04	3.042
Nuclear Envelope Breakdown	R-HSA-2980766	1.113290e-03	2.953
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.272973e-03	2.895
MTOR signalling	R-HSA-165159	1.249020e-03	2.903
Mitotic Anaphase	R-HSA-68882	1.330145e-03	2.876
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.418291e-03	2.848
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.495492e-03	2.825
Eukaryotic Translation Initiation	R-HSA-72613	1.591085e-03	2.798
Cap-dependent Translation Initiation	R-HSA-72737	1.591085e-03	2.798
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.646647e-03	2.783
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.692448e-03	2.771
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.961031e-03	2.708
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.185255e-03	2.660
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.220725e-03	2.654
Translation initiation complex formation	R-HSA-72649	2.213037e-03	2.655
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	2.277120e-03	2.643
Cell Cycle, Mitotic	R-HSA-69278	2.205437e-03	2.657
Chromatin modifying enzymes	R-HSA-3247509	2.132116e-03	2.671
Regulation of MECP2 expression and activity	R-HSA-9022692	2.450578e-03	2.611
rRNA modification in the nucleus and cytosol	R-HSA-6790901	2.384551e-03	2.623
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.585336e-03	2.587
Epigenetic regulation of gene expression	R-HSA-212165	2.555406e-03	2.593
Cell-extracellular matrix interactions	R-HSA-446353	2.847013e-03	2.546
Ribosomal scanning and start codon recognition	R-HSA-72702	2.850744e-03	2.545
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.900716e-03	2.537
PKMTs methylate histone lysines	R-HSA-3214841	2.996367e-03	2.523
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.153343e-03	2.501
Signaling by ALK in cancer	R-HSA-9700206	3.153343e-03	2.501
M Phase	R-HSA-68886	3.192021e-03	2.496
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	3.434106e-03	2.464
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.572393e-03	2.340
mTORC1-mediated signalling	R-HSA-166208	4.698986e-03	2.328
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.024056e-03	2.299
Signaling by Hippo	R-HSA-2028269	5.736602e-03	2.241
Cohesin Loading onto Chromatin	R-HSA-2470946	6.329587e-03	2.199
EGFR downregulation	R-HSA-182971	6.085365e-03	2.216
rRNA processing	R-HSA-72312	6.242855e-03	2.205
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	9.426831e-03	2.026
Diseases of Telomere Maintenance	R-HSA-9673013	9.426831e-03	2.026
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	9.426831e-03	2.026
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	9.426831e-03	2.026
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	9.426831e-03	2.026
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	9.426831e-03	2.026
Regulation of endogenous retroelements	R-HSA-9842860	9.331238e-03	2.030
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	8.763146e-03	2.057
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	9.748626e-03	2.011
Negative regulation of MET activity	R-HSA-6807004	1.033695e-02	1.986
ALK mutants bind TKIs	R-HSA-9700645	1.173803e-02	1.930
Unwinding of DNA	R-HSA-176974	1.173803e-02	1.930
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.103881e-02	1.957
MITF-M-dependent gene expression	R-HSA-9856651	1.219572e-02	1.914
MITF-M-regulated melanocyte development	R-HSA-9730414	1.253028e-02	1.902
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.375784e-02	1.861
Mitotic Prometaphase	R-HSA-68877	1.305466e-02	1.884
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.299530e-02	1.886
IRS activation	R-HSA-74713	1.468728e-02	1.833
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.468728e-02	1.833
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.529299e-02	1.816
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.636878e-02	1.786
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.625192e-02	1.789
Estrogen-dependent gene expression	R-HSA-9018519	1.751499e-02	1.757
Axon guidance	R-HSA-422475	1.751865e-02	1.756
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	2.080488e-02	1.682
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.910502e-02	1.719
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.003996e-02	1.698
mRNA Splicing - Minor Pathway	R-HSA-72165	1.808126e-02	1.743
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.808126e-02	1.743
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.111498e-02	1.675
Amplification of signal from the kinetochores	R-HSA-141424	2.111498e-02	1.675
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	2.080488e-02	1.682
Breakdown of the nuclear lamina	R-HSA-352238	2.023210e-02	1.694
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.106935e-02	1.676
Mitotic Prophase	R-HSA-68875	1.980286e-02	1.703
Signaling by EGFR	R-HSA-177929	1.956719e-02	1.708
Transcriptional Regulation by E2F6	R-HSA-8953750	2.003996e-02	1.698
Nervous system development	R-HSA-9675108	1.796645e-02	1.746
Signal Transduction	R-HSA-162582	1.952956e-02	1.709
ISG15 antiviral mechanism	R-HSA-1169408	1.933702e-02	1.714
NRAGE signals death through JNK	R-HSA-193648	1.956719e-02	1.708
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.217746e-02	1.654
Interactions of Rev with host cellular proteins	R-HSA-177243	2.239984e-02	1.650
Formation of a pool of free 40S subunits	R-HSA-72689	2.416612e-02	1.617
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.424026e-02	1.615
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.463688e-02	1.608
Nuclear RNA decay	R-HSA-9930044	2.463688e-02	1.608
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.811652e-02	1.551
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	2.972758e-02	1.527
Pervasive developmental disorders	R-HSA-9005895	2.972758e-02	1.527
Disorders of Nervous System Development	R-HSA-9697154	2.972758e-02	1.527
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.770923e-02	1.557
Regulation of PTEN gene transcription	R-HSA-8943724	2.800456e-02	1.553
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.972758e-02	1.527
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.847557e-02	1.546
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.010913e-02	1.521
Nuclear import of Rev protein	R-HSA-180746	3.103152e-02	1.508
p75 NTR receptor-mediated signalling	R-HSA-193704	3.149310e-02	1.502
Eukaryotic Translation Elongation	R-HSA-156842	3.685566e-02	1.433
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	3.634862e-02	1.440
Mitotic Spindle Checkpoint	R-HSA-69618	3.355338e-02	1.474
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	3.461095e-02	1.461
Transcriptional regulation by RUNX1	R-HSA-8878171	3.718190e-02	1.430
Signaling by ROBO receptors	R-HSA-376176	3.547627e-02	1.450
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.871209e-02	1.412
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.871209e-02	1.412
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	4.145619e-02	1.382
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	4.525017e-02	1.344
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	5.118078e-02	1.291
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	5.118078e-02	1.291
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	5.118078e-02	1.291
Type I hemidesmosome assembly	R-HSA-446107	4.627726e-02	1.335
G alpha (12/13) signalling events	R-HSA-416482	5.073598e-02	1.295
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	5.118078e-02	1.291
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	4.695300e-02	1.328
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.767837e-02	1.322
SARS-CoV-1-host interactions	R-HSA-9692914	5.076953e-02	1.294
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	4.895849e-02	1.310
NS1 Mediated Effects on Host Pathways	R-HSA-168276	5.161800e-02	1.287
Peptide chain elongation	R-HSA-156902	5.224486e-02	1.282
NGF-stimulated transcription	R-HSA-9031628	5.287041e-02	1.277
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	5.404294e-02	1.267
Sensory processing of sound	R-HSA-9659379	5.416450e-02	1.266
Influenza Infection	R-HSA-168255	5.473729e-02	1.262
Transcriptional Regulation by TP53	R-HSA-3700989	5.588681e-02	1.253
Nuclear signaling by ERBB4	R-HSA-1251985	5.656466e-02	1.247
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	5.974400e-02	1.224
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	6.126485e-02	1.213
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	6.950493e-02	1.158
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	7.036352e-02	1.153
Regulation of gap junction activity	R-HSA-191650	7.036352e-02	1.153
Inhibition of TSC complex formation by PKB	R-HSA-165181	7.036352e-02	1.153
GRB7 events in ERBB2 signaling	R-HSA-1306955	7.036352e-02	1.153
Deadenylation of mRNA	R-HSA-429947	6.817554e-02	1.166
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	6.618301e-02	1.179
Disorders of Developmental Biology	R-HSA-9675151	6.713100e-02	1.173
Activation of ATR in response to replication stress	R-HSA-176187	6.570106e-02	1.182
Signal attenuation	R-HSA-74749	6.892104e-02	1.162
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	6.179543e-02	1.209
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	6.817554e-02	1.166
Regulation of TP53 Activity	R-HSA-5633007	6.196045e-02	1.208
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	6.892104e-02	1.162
tRNA processing in the nucleus	R-HSA-6784531	7.047476e-02	1.152
Striated Muscle Contraction	R-HSA-390522	7.219650e-02	1.141
RNA Polymerase I Transcription Initiation	R-HSA-73762	7.311486e-02	1.136
Separation of Sister Chromatids	R-HSA-2467813	7.316921e-02	1.136
Sema4D in semaphorin signaling	R-HSA-400685	7.593804e-02	1.120
Cell Cycle Checkpoints	R-HSA-69620	7.699110e-02	1.114
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	7.772216e-02	1.109
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	7.805180e-02	1.108
Death Receptor Signaling	R-HSA-73887	7.805180e-02	1.108
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	7.904656e-02	1.102
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.129612e-02	1.090
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	8.235383e-02	1.084
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.415727e-02	1.075
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	8.557904e-02	1.068
RMTs methylate histone arginines	R-HSA-3214858	8.557904e-02	1.068
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	8.582247e-02	1.066
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	9.146396e-02	1.039
Post NMDA receptor activation events	R-HSA-438064	9.199926e-02	1.036
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	9.741051e-02	1.011
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.087043e-01	0.964
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.016917e-01	0.993
HATs acetylate histones	R-HSA-3214847	1.057756e-01	0.976
DNA Double Strand Break Response	R-HSA-5693606	9.707844e-02	1.013
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	9.561203e-02	1.019
Mitochondrial biogenesis	R-HSA-1592230	9.712956e-02	1.013
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.341828e-01	0.872
SARS-CoV-1 targets PDZ proteins in cell-cell junction	R-HSA-9692912	1.341828e-01	0.872
Defective MMADHC causes MMAHCD	R-HSA-3359473	1.943686e-01	0.711
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	1.943686e-01	0.711
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	1.943686e-01	0.711
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.503740e-01	0.601
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.503740e-01	0.601
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	2.503740e-01	0.601
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.503740e-01	0.601
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.503740e-01	0.601
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	2.503740e-01	0.601
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.503740e-01	0.601
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.503740e-01	0.601
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.503740e-01	0.601
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	2.503740e-01	0.601
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.503740e-01	0.601
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.503740e-01	0.601
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.503740e-01	0.601
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.503740e-01	0.601
MECP2 regulates transcription factors	R-HSA-9022707	1.628828e-01	0.788
SOS-mediated signalling	R-HSA-112412	1.628828e-01	0.788
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.628828e-01	0.788
Defective MMACHC causes MAHCC	R-HSA-3359474	3.024892e-01	0.519
Invadopodia formation	R-HSA-8941237	3.024892e-01	0.519
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.103072e-01	0.957
Signaling by MRAS-complex mutants	R-HSA-9660537	1.884527e-01	0.725
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.884527e-01	0.725
ARMS-mediated activation	R-HSA-170984	2.145147e-01	0.669
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	3.509842e-01	0.455
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	3.509842e-01	0.455
PLCG1 events in ERBB2 signaling	R-HSA-1251932	3.509842e-01	0.455
Defective LFNG causes SCDO3	R-HSA-5083630	3.509842e-01	0.455
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	2.408771e-01	0.618
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	1.329319e-01	0.876
Signaling by APC mutants	R-HSA-4839744	2.673722e-01	0.573
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.673722e-01	0.573
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.673722e-01	0.573
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.673722e-01	0.573
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	3.961102e-01	0.402
FLT3 signaling by CBL mutants	R-HSA-9706377	3.961102e-01	0.402
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.214095e-01	0.916
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.317531e-01	0.880
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.317531e-01	0.880
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	2.938546e-01	0.532
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.938546e-01	0.532
Signaling by GSK3beta mutants	R-HSA-5339716	2.938546e-01	0.532
Ephrin signaling	R-HSA-3928664	2.313634e-01	0.636
IPs transport between nucleus and cytosol	R-HSA-1855170	1.535672e-01	0.814
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	3.201979e-01	0.495
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	3.201979e-01	0.495
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	3.201979e-01	0.495
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	3.201979e-01	0.495
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	3.201979e-01	0.495
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	3.201979e-01	0.495
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	3.201979e-01	0.495
Nef Mediated CD8 Down-regulation	R-HSA-182218	4.381011e-01	0.358
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	4.381011e-01	0.358
Signaling by RNF43 mutants	R-HSA-5340588	4.381011e-01	0.358
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.163918e-01	0.665
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.163918e-01	0.665
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	2.695802e-01	0.569
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.888277e-01	0.724
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.315057e-01	0.635
HIV elongation arrest and recovery	R-HSA-167287	2.315057e-01	0.635
Formation of the Early Elongation Complex	R-HSA-113418	2.315057e-01	0.635
Pausing and recovery of HIV elongation	R-HSA-167290	2.315057e-01	0.635
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	3.462938e-01	0.461
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	2.011784e-01	0.696
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.468680e-01	0.608
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.137925e-01	0.670
Erythropoietin activates STAT5	R-HSA-9027283	4.771746e-01	0.321
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	4.771746e-01	0.321
Autointegration results in viral DNA circles	R-HSA-177539	4.771746e-01	0.321
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	4.771746e-01	0.321
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	1.129307e-01	0.947
FGFR2 alternative splicing	R-HSA-6803529	3.279330e-01	0.484
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	3.279330e-01	0.484
Notch-HLH transcription pathway	R-HSA-350054	3.279330e-01	0.484
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.940960e-01	0.532
Beta-catenin phosphorylation cascade	R-HSA-196299	3.973858e-01	0.401
RNA Polymerase III Chain Elongation	R-HSA-73780	3.973858e-01	0.401
snRNP Assembly	R-HSA-191859	2.125576e-01	0.673
Metabolism of non-coding RNA	R-HSA-194441	2.125576e-01	0.673
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	3.474333e-01	0.459
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	3.474333e-01	0.459
Signaling by RAF1 mutants	R-HSA-9656223	2.800529e-01	0.553
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.824881e-01	0.739
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.567864e-01	0.805
Formation of RNA Pol II elongation complex	R-HSA-112382	2.668188e-01	0.574
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.261962e-01	0.487
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	4.222371e-01	0.374
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	5.135331e-01	0.289
IFNG signaling activates MAPKs	R-HSA-9732724	5.135331e-01	0.289
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	5.135331e-01	0.289
Recycling of eIF2:GDP	R-HSA-72731	5.135331e-01	0.289
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	5.135331e-01	0.289
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	5.135331e-01	0.289
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	2.332314e-01	0.632
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.544618e-01	0.594
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.544618e-01	0.594
RNA Polymerase II Transcription Elongation	R-HSA-75955	2.789181e-01	0.555
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.789181e-01	0.555
RAF activation	R-HSA-5673000	3.423351e-01	0.466
Viral mRNA Translation	R-HSA-192823	2.050502e-01	0.688
Centrosome maturation	R-HSA-380287	2.527728e-01	0.597
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	2.503013e-01	0.602
AURKA Activation by TPX2	R-HSA-8854518	2.873521e-01	0.542
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	4.054096e-01	0.392
Signaling downstream of RAS mutants	R-HSA-9649948	3.496393e-01	0.456
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	3.496393e-01	0.456
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	3.496393e-01	0.456
Interaction between L1 and Ankyrins	R-HSA-445095	4.244238e-01	0.372
EPHA-mediated growth cone collapse	R-HSA-3928663	4.244238e-01	0.372
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	5.473652e-01	0.262
Formation of annular gap junctions	R-HSA-196025	5.473652e-01	0.262
Myoclonic epilepsy of Lafora	R-HSA-3785653	5.473652e-01	0.262
Activation of AMPK downstream of NMDARs	R-HSA-9619483	4.432228e-01	0.353
RNA Polymerase III Transcription Termination	R-HSA-73980	4.933788e-01	0.307
Late endosomal microautophagy	R-HSA-9615710	4.617759e-01	0.336
Attenuation phase	R-HSA-3371568	4.386385e-01	0.358
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.386385e-01	0.358
HSF1-dependent transactivation	R-HSA-3371571	4.199977e-01	0.377
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.800555e-01	0.319
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.800555e-01	0.319
Regulation of signaling by CBL	R-HSA-912631	5.158338e-01	0.287
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	5.788463e-01	0.237
WNT mediated activation of DVL	R-HSA-201688	5.788463e-01	0.237
Gap junction degradation	R-HSA-190873	5.788463e-01	0.237
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	3.994202e-01	0.399
Meiotic synapsis	R-HSA-1221632	4.478496e-01	0.349
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	4.853679e-01	0.314
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	6.081396e-01	0.216
Developmental Lineages of the Mammary Gland	R-HSA-9924644	5.158426e-01	0.287
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.593944e-01	0.252
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	5.988176e-01	0.223
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	6.353971e-01	0.197
HSF1 activation	R-HSA-3371511	5.986263e-01	0.223
PRC2 methylates histones and DNA	R-HSA-212300	5.986263e-01	0.223
Condensation of Prometaphase Chromosomes	R-HSA-2514853	6.607600e-01	0.180
Synthesis of diphthamide-EEF2	R-HSA-5358493	6.607600e-01	0.180
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.578874e-01	0.182
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.578874e-01	0.182
Transcription of the HIV genome	R-HSA-167172	6.390824e-01	0.194
PKR-mediated signaling	R-HSA-9833482	6.077089e-01	0.216
RNA Polymerase III Transcription	R-HSA-74158	2.011784e-01	0.696
Signaling by NOTCH2	R-HSA-1980145	5.665852e-01	0.247
Transcriptional Regulation by MECP2	R-HSA-8986944	2.974840e-01	0.527
Nucleotide Excision Repair	R-HSA-5696398	6.057407e-01	0.218
HIV Transcription Elongation	R-HSA-167169	4.386385e-01	0.358
Recycling pathway of L1	R-HSA-437239	2.086830e-01	0.681
EPH-Ephrin signaling	R-HSA-2682334	3.169528e-01	0.499
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	4.933788e-01	0.307
RNA Polymerase III Transcription Initiation	R-HSA-76046	1.214095e-01	0.916
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	5.587157e-01	0.253
Oncogenic MAPK signaling	R-HSA-6802957	1.397568e-01	0.855
mRNA Capping	R-HSA-72086	4.617759e-01	0.336
Ribosome-associated quality control	R-HSA-9948299	2.334223e-01	0.632
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.386385e-01	0.358
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	4.937042e-01	0.307
Prolonged ERK activation events	R-HSA-169893	1.763423e-01	0.754
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.504081e-01	0.187
Activation of the pre-replicative complex	R-HSA-68962	2.624435e-01	0.581
G0 and Early G1	R-HSA-1538133	2.940960e-01	0.532
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.386385e-01	0.358
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	5.665852e-01	0.247
Aggrephagy	R-HSA-9646399	4.386385e-01	0.358
Cellular response to heat stress	R-HSA-3371556	2.718108e-01	0.566
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.214095e-01	0.916
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	4.915857e-01	0.308
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.400045e-01	0.194
Frs2-mediated activation	R-HSA-170968	3.462938e-01	0.461
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	4.954676e-01	0.305
Metalloprotease DUBs	R-HSA-5689901	2.015621e-01	0.696
MAP2K and MAPK activation	R-HSA-5674135	2.800529e-01	0.553
TRAF3-dependent IRF activation pathway	R-HSA-918233	4.465482e-01	0.350
UCH proteinases	R-HSA-5689603	5.629221e-01	0.250
PI3K/AKT activation	R-HSA-198203	2.408771e-01	0.618
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	1.458042e-01	0.836
Diseases of mitotic cell cycle	R-HSA-9675126	2.940960e-01	0.532
WNT5A-dependent internalization of FZD4	R-HSA-5099900	4.222371e-01	0.374
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.627323e-01	0.580
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.702742e-01	0.328
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.227783e-01	0.374
VxPx cargo-targeting to cilium	R-HSA-5620916	5.376179e-01	0.270
LGI-ADAM interactions	R-HSA-5682910	6.353971e-01	0.197
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	5.830551e-01	0.234
RNA Polymerase I Transcription	R-HSA-73864	2.829856e-01	0.548
Cellular response to starvation	R-HSA-9711097	2.076008e-01	0.683
Signaling by RAS mutants	R-HSA-6802949	3.496393e-01	0.456
Regulation of TP53 Degradation	R-HSA-6804757	5.986263e-01	0.223
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.787202e-01	0.422
Adipogenesis	R-HSA-9843745	2.666380e-01	0.574
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.942831e-01	0.712
PKA activation	R-HSA-163615	2.313634e-01	0.636
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.273610e-01	0.895
VLDLR internalisation and degradation	R-HSA-8866427	3.201979e-01	0.495
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	4.381011e-01	0.358
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	2.468680e-01	0.608
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	3.474333e-01	0.459
Nucleosome assembly	R-HSA-774815	3.355827e-01	0.474
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	3.355827e-01	0.474
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	5.473652e-01	0.262
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	5.788463e-01	0.237
Trafficking of AMPA receptors	R-HSA-399719	4.980368e-01	0.303
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.481580e-01	0.349
Binding and entry of HIV virion	R-HSA-173107	6.081396e-01	0.216
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.969811e-01	0.304
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	5.986263e-01	0.223
TRAF6 mediated NF-kB activation	R-HSA-933542	6.361131e-01	0.196
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.154429e-01	0.938
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.919120e-01	0.407
Repression of WNT target genes	R-HSA-4641265	3.201979e-01	0.495
Clathrin-mediated endocytosis	R-HSA-8856828	1.268536e-01	0.897
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.244238e-01	0.372
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.270689e-01	0.370
Integration of provirus	R-HSA-162592	6.607600e-01	0.180
Deadenylation-dependent mRNA decay	R-HSA-429914	3.535509e-01	0.452
Chaperone Mediated Autophagy	R-HSA-9613829	2.313634e-01	0.636
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.141233e-01	0.943
Formation of the posterior neural plate	R-HSA-9832991	2.673722e-01	0.573
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	3.961102e-01	0.402
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	3.201979e-01	0.495
Defects in biotin (Btn) metabolism	R-HSA-3323169	5.788463e-01	0.237
Late Phase of HIV Life Cycle	R-HSA-162599	3.697043e-01	0.432
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	5.587157e-01	0.253
Regulation of TP53 Expression and Degradation	R-HSA-6806003	6.436865e-01	0.191
Circadian clock	R-HSA-9909396	1.874253e-01	0.727
Signaling by WNT in cancer	R-HSA-4791275	5.156983e-01	0.288
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.884527e-01	0.725
Lipophagy	R-HSA-9613354	2.145147e-01	0.669
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	3.961102e-01	0.402
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	4.381011e-01	0.358
Aryl hydrocarbon receptor signalling	R-HSA-8937144	4.381011e-01	0.358
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	4.771746e-01	0.321
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	4.771746e-01	0.321
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.279330e-01	0.484
Eukaryotic Translation Termination	R-HSA-72764	1.489822e-01	0.827
Nef Mediated CD4 Down-regulation	R-HSA-167590	5.135331e-01	0.289
HDACs deacetylate histones	R-HSA-3214815	3.034676e-01	0.518
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	4.702742e-01	0.328
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	5.788463e-01	0.237
HIV Life Cycle	R-HSA-162587	2.015912e-01	0.696
Apoptosis induced DNA fragmentation	R-HSA-140342	6.081396e-01	0.216
Neurexins and neuroligins	R-HSA-6794361	1.464866e-01	0.834
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	1.273610e-01	0.895
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	1.273610e-01	0.895
Negative regulation of FGFR3 signaling	R-HSA-5654732	4.432228e-01	0.353
Negative regulation of FGFR4 signaling	R-HSA-5654733	4.617759e-01	0.336
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.665852e-01	0.247
Signalling to ERKs	R-HSA-187687	5.828013e-01	0.234
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	5.788463e-01	0.237
Chromosome Maintenance	R-HSA-73886	2.718108e-01	0.566
HIV Infection	R-HSA-162906	3.300165e-01	0.481
Signaling by FGFR2	R-HSA-5654738	6.077089e-01	0.216
Polo-like kinase mediated events	R-HSA-156711	4.933788e-01	0.307
Negative regulation of FGFR1 signaling	R-HSA-5654726	5.330208e-01	0.273
Telomere Maintenance	R-HSA-157579	6.597847e-01	0.181
Inhibition of PKR	R-HSA-169131	1.341828e-01	0.872
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	1.943686e-01	0.711
Transport of connexins along the secretory pathway	R-HSA-190827	1.943686e-01	0.711
Manipulation of host energy metabolism	R-HSA-9636667	1.943686e-01	0.711
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	2.503740e-01	0.601
MET interacts with TNS proteins	R-HSA-8875513	3.024892e-01	0.519
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.258042e-01	0.900
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	2.408771e-01	0.618
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	2.673722e-01	0.573
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	3.961102e-01	0.402
Reelin signalling pathway	R-HSA-8866376	3.961102e-01	0.402
Signaling by AMER1 mutants	R-HSA-4839748	2.938546e-01	0.532
Signaling by AXIN mutants	R-HSA-4839735	2.938546e-01	0.532
PKA activation in glucagon signalling	R-HSA-164378	2.313634e-01	0.636
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.273610e-01	0.895
Noncanonical activation of NOTCH3	R-HSA-9017802	4.381011e-01	0.358
Kinesins	R-HSA-983189	2.227917e-01	0.652
Viral Messenger RNA Synthesis	R-HSA-168325	2.331943e-01	0.632
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.355827e-01	0.474
Adrenoceptors	R-HSA-390696	5.473652e-01	0.262
Axonal growth inhibition (RHOA activation)	R-HSA-193634	5.473652e-01	0.262
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	4.933788e-01	0.307
G2/M DNA damage checkpoint	R-HSA-69473	3.787202e-01	0.422
G2/M Checkpoints	R-HSA-69481	3.291644e-01	0.483
Orc1 removal from chromatin	R-HSA-68949	4.339607e-01	0.363
Signaling by FGFR2 IIIa TM	R-HSA-8851708	5.158338e-01	0.287
Inactivation of CDC42 and RAC1	R-HSA-428543	5.788463e-01	0.237
MASTL Facilitates Mitotic Progression	R-HSA-2465910	5.788463e-01	0.237
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	6.081396e-01	0.216
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	6.081396e-01	0.216
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.499878e-01	0.260
Switching of origins to a post-replicative state	R-HSA-69052	5.278037e-01	0.278
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	5.791174e-01	0.237
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.791174e-01	0.237
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	5.665852e-01	0.247
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	6.607600e-01	0.180
NF-kB is activated and signals survival	R-HSA-209560	6.607600e-01	0.180
Autophagy	R-HSA-9612973	2.775299e-01	0.557
Mitotic G1 phase and G1/S transition	R-HSA-453279	6.339716e-01	0.198
Oncogene Induced Senescence	R-HSA-2559585	5.828013e-01	0.234
Mismatch Repair	R-HSA-5358508	4.933788e-01	0.307
Hedgehog 'off' state	R-HSA-5610787	5.469656e-01	0.262
Selective autophagy	R-HSA-9663891	2.688837e-01	0.570
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	2.408771e-01	0.618
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.409438e-01	0.467
Spry regulation of FGF signaling	R-HSA-1295596	3.973858e-01	0.401
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	5.158338e-01	0.287
CD209 (DC-SIGN) signaling	R-HSA-5621575	6.361131e-01	0.196
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	6.178154e-01	0.209
Macroautophagy	R-HSA-1632852	2.544268e-01	0.594
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.578874e-01	0.182
DNA Double-Strand Break Repair	R-HSA-5693532	3.520600e-01	0.453
ESR-mediated signaling	R-HSA-8939211	3.103136e-01	0.508
Membrane Trafficking	R-HSA-199991	2.147752e-01	0.668
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.138869e-01	0.944
Early Phase of HIV Life Cycle	R-HSA-162594	2.889530e-01	0.539
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	3.961102e-01	0.402
PKA-mediated phosphorylation of CREB	R-HSA-111931	2.889530e-01	0.539
NRIF signals cell death from the nucleus	R-HSA-205043	3.720493e-01	0.429
Host Interactions of HIV factors	R-HSA-162909	2.960172e-01	0.529
Organelle biogenesis and maintenance	R-HSA-1852241	4.063433e-01	0.391
DCC mediated attractive signaling	R-HSA-418885	3.973858e-01	0.401
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.232918e-01	0.651
Regulation of TP53 Activity through Methylation	R-HSA-6804760	4.933788e-01	0.307
Interferon Signaling	R-HSA-913531	6.077603e-01	0.216
Deubiquitination	R-HSA-5688426	1.444468e-01	0.840
Processing of DNA double-strand break ends	R-HSA-5693607	3.140702e-01	0.503
Negative regulation of MAPK pathway	R-HSA-5675221	4.699523e-01	0.328
Signaling by NOTCH1	R-HSA-1980143	5.629221e-01	0.250
Transcriptional regulation of granulopoiesis	R-HSA-9616222	2.437547e-01	0.613
Gene expression (Transcription)	R-HSA-74160	1.820775e-01	0.740
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.650016e-01	0.783
Heme signaling	R-HSA-9707616	1.373990e-01	0.862
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.135331e-01	0.289
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	5.788463e-01	0.237
Activation of the AP-1 family of transcription factors	R-HSA-450341	5.788463e-01	0.237
Transcriptional regulation by small RNAs	R-HSA-5578749	5.158426e-01	0.287
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.543698e-01	0.343
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.215368e-01	0.915
Calmodulin induced events	R-HSA-111933	2.011784e-01	0.696
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.828013e-01	0.234
DNA Repair	R-HSA-73894	6.313206e-01	0.200
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	6.159975e-01	0.210
TGFBR3 expression	R-HSA-9839394	1.870526e-01	0.728
CaM pathway	R-HSA-111997	2.011784e-01	0.696
p75NTR regulates axonogenesis	R-HSA-193697	5.788463e-01	0.237
Rab regulation of trafficking	R-HSA-9007101	4.701707e-01	0.328
Cellular Senescence	R-HSA-2559583	2.728191e-01	0.564
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	4.465482e-01	0.350
Protein-protein interactions at synapses	R-HSA-6794362	3.564607e-01	0.448
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	6.390824e-01	0.194
TBC/RABGAPs	R-HSA-8854214	1.658949e-01	0.780
DAG and IP3 signaling	R-HSA-1489509	1.868087e-01	0.729
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	6.140525e-01	0.212
RNA Polymerase II Transcription	R-HSA-73857	5.345845e-01	0.272
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.575151e-01	0.803
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	5.593944e-01	0.252
Ub-specific processing proteases	R-HSA-5689880	6.258152e-01	0.204
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.146347e-01	0.941
G2/M Transition	R-HSA-69275	5.108620e-01	0.292
Oligomerization of connexins into connexons	R-HSA-190704	1.943686e-01	0.711
Inhibition of membrane repair	R-HSA-9635644	1.943686e-01	0.711
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.024892e-01	0.519
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.258042e-01	0.900
GP1b-IX-V activation signalling	R-HSA-430116	2.145147e-01	0.669
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.145147e-01	0.669
Cellular response to mitochondrial stress	R-HSA-9840373	2.145147e-01	0.669
Sensory perception of sour taste	R-HSA-9729555	3.509842e-01	0.455
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	3.509842e-01	0.455
Signalling to p38 via RIT and RIN	R-HSA-187706	4.381011e-01	0.358
Integration of viral DNA into host genomic DNA	R-HSA-175567	4.771746e-01	0.321
Ca-dependent events	R-HSA-111996	2.937897e-01	0.532
VLDL clearance	R-HSA-8964046	5.135331e-01	0.289
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	2.911394e-01	0.536
TGFBR3 PTM regulation	R-HSA-9839383	5.473652e-01	0.262
Regulation of signaling by NODAL	R-HSA-1433617	5.788463e-01	0.237
Evasion by RSV of host interferon responses	R-HSA-9833109	4.980368e-01	0.303
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	3.278098e-01	0.484
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.330208e-01	0.273
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	6.081396e-01	0.216
2-LTR circle formation	R-HSA-164843	6.081396e-01	0.216
Mitotic G2-G2/M phases	R-HSA-453274	5.258633e-01	0.279
RHOBTB3 ATPase cycle	R-HSA-9706019	6.353971e-01	0.197
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.361131e-01	0.196
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	6.607600e-01	0.180
Maternal to zygotic transition (MZT)	R-HSA-9816359	4.005007e-01	0.397
L1CAM interactions	R-HSA-373760	5.920359e-01	0.228
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	1.145342e-01	0.941
Smooth Muscle Contraction	R-HSA-445355	6.400045e-01	0.194
Cellular responses to mechanical stimuli	R-HSA-9855142	5.549447e-01	0.256
S Phase	R-HSA-69242	2.232369e-01	0.651
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.778227e-01	0.423
Pexophagy	R-HSA-9664873	6.081396e-01	0.216
Protein hydroxylation	R-HSA-9629569	2.695802e-01	0.569
Oxidative Stress Induced Senescence	R-HSA-2559580	4.270689e-01	0.370
Carnitine shuttle	R-HSA-200425	6.178154e-01	0.209
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	6.607600e-01	0.180
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.549447e-01	0.256
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	3.440564e-01	0.463
Semaphorin interactions	R-HSA-373755	2.544618e-01	0.594
Homology Directed Repair	R-HSA-5693538	4.795880e-01	0.319
Regulation of NFE2L2 gene expression	R-HSA-9818749	4.771746e-01	0.321
Selenocysteine synthesis	R-HSA-2408557	1.902454e-01	0.721
Receptor Mediated Mitophagy	R-HSA-8934903	6.081396e-01	0.216
PLC beta mediated events	R-HSA-112043	5.546835e-01	0.256
Cell junction organization	R-HSA-446728	1.374257e-01	0.862
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.133374e-01	0.504
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.133374e-01	0.504
MHC class II antigen presentation	R-HSA-2132295	5.260438e-01	0.279
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	6.178154e-01	0.209
Netrin-1 signaling	R-HSA-373752	5.156314e-01	0.288
Signaling by NTRKs	R-HSA-166520	3.134701e-01	0.504
Glycolysis	R-HSA-70171	4.068954e-01	0.391
Mitophagy	R-HSA-5205647	5.665852e-01	0.247
Cell-Cell communication	R-HSA-1500931	1.391852e-01	0.856
SARS-CoV-2-host interactions	R-HSA-9705683	5.193039e-01	0.285
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	2.503740e-01	0.601
Displacement of DNA glycosylase by APEX1	R-HSA-110357	1.628828e-01	0.788
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.628828e-01	0.788
FLT3 signaling through SRC family kinases	R-HSA-9706374	3.509842e-01	0.455
Bicarbonate transporters	R-HSA-425381	2.673722e-01	0.573
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	3.961102e-01	0.402
DARPP-32 events	R-HSA-180024	2.468680e-01	0.608
NADPH regeneration	R-HSA-389542	4.771746e-01	0.321
LDL clearance	R-HSA-8964038	3.279330e-01	0.484
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.664487e-01	0.574
Cation-coupled Chloride cotransporters	R-HSA-426117	5.135331e-01	0.289
Regulation of PTEN localization	R-HSA-8948747	5.135331e-01	0.289
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.728211e-01	0.762
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	5.473652e-01	0.262
Sodium/Proton exchangers	R-HSA-425986	5.473652e-01	0.262
Plasma lipoprotein clearance	R-HSA-8964043	4.227783e-01	0.374
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	5.788463e-01	0.237
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	6.272607e-01	0.203
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.436865e-01	0.191
MicroRNA (miRNA) biogenesis	R-HSA-203927	6.537161e-01	0.185
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.100222e-01	0.215
Zygotic genome activation (ZGA)	R-HSA-9819196	5.587157e-01	0.253
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	6.272607e-01	0.203
FLT3 signaling in disease	R-HSA-9682385	5.986263e-01	0.223
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.236664e-01	0.650
Neurodegenerative Diseases	R-HSA-8863678	1.728993e-01	0.762
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.728993e-01	0.762
Intracellular signaling by second messengers	R-HSA-9006925	2.434744e-01	0.614
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.820815e-01	0.317
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.591381e-01	0.798
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	5.499878e-01	0.260
Sensing of DNA Double Strand Breaks	R-HSA-5693548	6.607600e-01	0.180
G-protein mediated events	R-HSA-112040	6.276480e-01	0.202
Signaling by MET	R-HSA-6806834	3.036265e-01	0.518
Regulation of CDH11 gene transcription	R-HSA-9762293	2.145147e-01	0.669
Myogenesis	R-HSA-525793	4.054096e-01	0.392
Ovarian tumor domain proteases	R-HSA-5689896	6.140525e-01	0.212
Adherens junctions interactions	R-HSA-418990	5.469400e-01	0.262
Signaling by ERBB4	R-HSA-1236394	3.787202e-01	0.422
Inositol phosphate metabolism	R-HSA-1483249	5.358993e-01	0.271
STING mediated induction of host immune responses	R-HSA-1834941	5.158338e-01	0.287
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.163918e-01	0.665
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.329319e-01	0.876
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.961102e-01	0.402
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	2.938546e-01	0.532
DNA strand elongation	R-HSA-69190	1.424781e-01	0.846
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	4.381011e-01	0.358
Formation of the anterior neural plate	R-HSA-9823739	3.973858e-01	0.401
IRF3-mediated induction of type I IFN	R-HSA-3270619	3.973858e-01	0.401
Uptake and function of diphtheria toxin	R-HSA-5336415	5.135331e-01	0.289
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.496393e-01	0.456
Regulated proteolysis of p75NTR	R-HSA-193692	5.788463e-01	0.237
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	5.788463e-01	0.237
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	6.353971e-01	0.197
Glucose metabolism	R-HSA-70326	6.010785e-01	0.221
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	3.973858e-01	0.401
PIP3 activates AKT signaling	R-HSA-1257604	4.190356e-01	0.378
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	6.504081e-01	0.187
Signaling by TGFBR3	R-HSA-9839373	3.496393e-01	0.456
Apoptosis	R-HSA-109581	2.324302e-01	0.634
Signaling by PDGFR in disease	R-HSA-9671555	1.329319e-01	0.876
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	5.788463e-01	0.237
Josephin domain DUBs	R-HSA-5689877	6.081396e-01	0.216
Glucagon signaling in metabolic regulation	R-HSA-163359	5.499878e-01	0.260
Hyaluronan degradation	R-HSA-2160916	6.537161e-01	0.185
PTEN Regulation	R-HSA-6807070	4.492175e-01	0.348
Nephrin family interactions	R-HSA-373753	2.695802e-01	0.569
Formation of definitive endoderm	R-HSA-9823730	5.376179e-01	0.270
Interleukin-27 signaling	R-HSA-9020956	6.081396e-01	0.216
Gene Silencing by RNA	R-HSA-211000	4.871073e-01	0.312
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	3.973858e-01	0.401
ROBO receptors bind AKAP5	R-HSA-9010642	5.473652e-01	0.262
Signaling by ALK	R-HSA-201556	4.227783e-01	0.374
Suppression of apoptosis	R-HSA-9635465	6.353971e-01	0.197
Collagen chain trimerization	R-HSA-8948216	6.140525e-01	0.212
Specification of the neural plate border	R-HSA-9834899	5.158338e-01	0.287
Programmed Cell Death	R-HSA-5357801	4.548254e-01	0.342
RET signaling	R-HSA-8853659	3.746432e-01	0.426
Maturation of spike protein	R-HSA-9683686	6.081396e-01	0.216
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	4.222371e-01	0.374
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	5.288538e-01	0.277
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.612897e-01	0.792
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	4.465482e-01	0.350
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	5.587157e-01	0.253
Miscellaneous transport and binding events	R-HSA-5223345	5.499878e-01	0.260
XBP1(S) activates chaperone genes	R-HSA-381038	1.533721e-01	0.814
Signaling by Leptin	R-HSA-2586552	2.408771e-01	0.618
Specification of primordial germ cells	R-HSA-9827857	4.702742e-01	0.328
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.988176e-01	0.223
Interleukin-2 signaling	R-HSA-9020558	6.353971e-01	0.197
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	3.462938e-01	0.461
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.290739e-01	0.201
IRE1alpha activates chaperones	R-HSA-381070	1.979282e-01	0.703
SARS-CoV-1 Infection	R-HSA-9678108	2.408632e-01	0.618
Unfolded Protein Response (UPR)	R-HSA-381119	2.403449e-01	0.619
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	5.791174e-01	0.237
Selenoamino acid metabolism	R-HSA-2408522	6.591602e-01	0.181
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.853679e-01	0.314
Interleukin-12 family signaling	R-HSA-447115	2.595394e-01	0.586
Interleukin-7 signaling	R-HSA-1266695	3.862143e-01	0.413
Interleukin-12 signaling	R-HSA-9020591	2.627323e-01	0.580
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	6.537161e-01	0.185
Assembly of Viral Components at the Budding Site	R-HSA-168316	3.961102e-01	0.402
Growth hormone receptor signaling	R-HSA-982772	6.178154e-01	0.209
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.612878e-01	0.180
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.612878e-01	0.180
Cell-cell junction organization	R-HSA-421270	6.671217e-01	0.176
Signaling by FLT3 fusion proteins	R-HSA-9703465	6.706325e-01	0.174
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	6.706325e-01	0.174
NoRC negatively regulates rRNA expression	R-HSA-427413	6.720527e-01	0.173
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	6.764947e-01	0.170
TNF signaling	R-HSA-75893	6.764947e-01	0.170
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	6.795795e-01	0.168
trans-Golgi Network Vesicle Budding	R-HSA-199992	6.825891e-01	0.166
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	6.825891e-01	0.166
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	6.843601e-01	0.165
Scavenging by Class F Receptors	R-HSA-3000484	6.843601e-01	0.165
RUNX3 regulates p14-ARF	R-HSA-8951936	6.843601e-01	0.165
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	6.843601e-01	0.165
RUNX3 regulates NOTCH signaling	R-HSA-8941856	6.843601e-01	0.165
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.843601e-01	0.165
Serotonin clearance from the synaptic cleft	R-HSA-380615	6.843601e-01	0.165
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	6.843601e-01	0.165
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	6.843601e-01	0.165
p75NTR recruits signalling complexes	R-HSA-209543	6.843601e-01	0.165
Signaling by LTK	R-HSA-9842663	6.843601e-01	0.165
Trafficking and processing of endosomal TLR	R-HSA-1679131	6.843601e-01	0.165
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	6.843601e-01	0.165
MET activates RAS signaling	R-HSA-8851805	6.843601e-01	0.165
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	6.843601e-01	0.165
Interleukin-35 Signalling	R-HSA-8984722	6.843601e-01	0.165
OAS antiviral response	R-HSA-8983711	6.843601e-01	0.165
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	6.850508e-01	0.164
HIV Transcription Initiation	R-HSA-167161	6.850508e-01	0.164
RNA Polymerase II Transcription Initiation	R-HSA-75953	6.850508e-01	0.164
Signaling by FGFR1 in disease	R-HSA-5655302	6.850508e-01	0.164
SLC-mediated transport of neurotransmitters	R-HSA-442660	6.850508e-01	0.164
RNA Polymerase I Transcription Termination	R-HSA-73863	6.868727e-01	0.163
Cristae formation	R-HSA-8949613	6.868727e-01	0.163
Triglyceride biosynthesis	R-HSA-75109	6.868727e-01	0.163
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	6.868727e-01	0.163
Cellular responses to stimuli	R-HSA-8953897	6.904414e-01	0.161
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	6.928955e-01	0.159
Platelet degranulation	R-HSA-114608	6.934429e-01	0.159
Cellular responses to stress	R-HSA-2262752	6.937710e-01	0.159
TCF dependent signaling in response to WNT	R-HSA-201681	6.950181e-01	0.158
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	6.972486e-01	0.157
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	6.980147e-01	0.156
Diseases of programmed cell death	R-HSA-9645723	6.984644e-01	0.156
Telomere Extension By Telomerase	R-HSA-171319	7.024489e-01	0.153
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	7.024489e-01	0.153
Signaling by FGFR in disease	R-HSA-1226099	7.029705e-01	0.153
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	7.063197e-01	0.151
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	7.063197e-01	0.151
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	7.063197e-01	0.151
Formation of axial mesoderm	R-HSA-9796292	7.063197e-01	0.151
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	7.063197e-01	0.151
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	7.063197e-01	0.151
PI5P Regulates TP53 Acetylation	R-HSA-6811555	7.063197e-01	0.151
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	7.063197e-01	0.151
Reversible hydration of carbon dioxide	R-HSA-1475029	7.063197e-01	0.151
Processing of SMDT1	R-HSA-8949664	7.063197e-01	0.151
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	7.063197e-01	0.151
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	7.063197e-01	0.151
Maturation of nucleoprotein	R-HSA-9683610	7.063197e-01	0.151
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	7.063197e-01	0.151
Interleukin-6 signaling	R-HSA-1059683	7.063197e-01	0.151
Vesicle-mediated transport	R-HSA-5653656	7.077092e-01	0.150
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	7.084853e-01	0.150
Developmental Biology	R-HSA-1266738	7.102269e-01	0.149
Extension of Telomeres	R-HSA-180786	7.103312e-01	0.149
RNA Polymerase II Promoter Escape	R-HSA-73776	7.105694e-01	0.148
Signaling by FGFR4	R-HSA-5654743	7.105694e-01	0.148
Response of Mtb to phagocytosis	R-HSA-9637690	7.105694e-01	0.148
Signaling by SCF-KIT	R-HSA-1433557	7.105694e-01	0.148
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.128134e-01	0.147
Protein ubiquitination	R-HSA-8852135	7.128134e-01	0.147
Regulation of gene expression in beta cells	R-HSA-210745	7.173747e-01	0.144
Regulation of CDH11 Expression and Function	R-HSA-9759475	7.173747e-01	0.144
Response of endothelial cells to shear stress	R-HSA-9860931	7.210167e-01	0.142
Signaling by ERBB2	R-HSA-1227986	7.210179e-01	0.142
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	7.210179e-01	0.142
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	7.210179e-01	0.142
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	7.210179e-01	0.142
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	7.210179e-01	0.142
Signaling by NOTCH1 in Cancer	R-HSA-2644603	7.210179e-01	0.142
Retrograde neurotrophin signalling	R-HSA-177504	7.267527e-01	0.139
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.267527e-01	0.139
CRMPs in Sema3A signaling	R-HSA-399956	7.267527e-01	0.139
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	7.267527e-01	0.139
Signaling by FGFR4 in disease	R-HSA-5655291	7.267527e-01	0.139
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	7.267527e-01	0.139
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	7.267527e-01	0.139
Regulation of KIT signaling	R-HSA-1433559	7.267527e-01	0.139
Zinc transporters	R-HSA-435354	7.267527e-01	0.139
IRS-related events triggered by IGF1R	R-HSA-2428928	7.314098e-01	0.136
Signaling by ERBB2 in Cancer	R-HSA-1227990	7.316654e-01	0.136
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	7.316654e-01	0.136
Downregulation of ERBB2 signaling	R-HSA-8863795	7.316654e-01	0.136
Interleukin-37 signaling	R-HSA-9008059	7.316654e-01	0.136
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.344656e-01	0.134
Asymmetric localization of PCP proteins	R-HSA-4608870	7.344656e-01	0.134
Signaling by FGFR3	R-HSA-5654741	7.344656e-01	0.134
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.344656e-01	0.134
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.344656e-01	0.134
Golgi-to-ER retrograde transport	R-HSA-8856688	7.377476e-01	0.132
PCP/CE pathway	R-HSA-4086400	7.409478e-01	0.130
NCAM signaling for neurite out-growth	R-HSA-375165	7.415085e-01	0.130
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	7.446912e-01	0.128
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.453369e-01	0.128
Erythropoietin activates RAS	R-HSA-9027284	7.457652e-01	0.127
ERBB2 Regulates Cell Motility	R-HSA-6785631	7.457652e-01	0.127
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	7.457652e-01	0.127
p75NTR signals via NF-kB	R-HSA-193639	7.457652e-01	0.127
Biotin transport and metabolism	R-HSA-196780	7.457652e-01	0.127
DNA Damage Reversal	R-HSA-73942	7.457652e-01	0.127
Processive synthesis on the lagging strand	R-HSA-69183	7.457652e-01	0.127
Protein methylation	R-HSA-8876725	7.457652e-01	0.127
Regulation of TNFR1 signaling	R-HSA-5357905	7.458162e-01	0.127
Assembly of the pre-replicative complex	R-HSA-68867	7.505388e-01	0.125
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	7.513162e-01	0.124
Signaling by PTK6	R-HSA-8848021	7.513162e-01	0.124
Synthesis of DNA	R-HSA-69239	7.524427e-01	0.124
Collagen formation	R-HSA-1474290	7.585475e-01	0.120
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	7.585476e-01	0.120
Insulin receptor signalling cascade	R-HSA-74751	7.608355e-01	0.119
IGF1R signaling cascade	R-HSA-2428924	7.608355e-01	0.119
Gastrulation	R-HSA-9758941	7.615933e-01	0.118
Phosphorylation of the APC/C	R-HSA-176412	7.634559e-01	0.117
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	7.634559e-01	0.117
Killing mechanisms	R-HSA-9664420	7.634559e-01	0.117
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	7.634559e-01	0.117
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.634559e-01	0.117
Class I peroxisomal membrane protein import	R-HSA-9603798	7.634559e-01	0.117
Negative regulation of FLT3	R-HSA-9706369	7.634559e-01	0.117
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.634559e-01	0.117
Activation of SMO	R-HSA-5635838	7.634559e-01	0.117
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	7.634559e-01	0.117
Virus Assembly and Release	R-HSA-168268	7.634559e-01	0.117
GPER1 signaling	R-HSA-9634597	7.673510e-01	0.115
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	7.700694e-01	0.113
Cellular response to hypoxia	R-HSA-1234174	7.700694e-01	0.113
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	7.708910e-01	0.113
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	7.708910e-01	0.113
FGFR1 mutant receptor activation	R-HSA-1839124	7.708910e-01	0.113
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	7.708910e-01	0.113
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	7.708910e-01	0.113
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	7.708910e-01	0.113
HCMV Early Events	R-HSA-9609690	7.725711e-01	0.112
DNA Damage Bypass	R-HSA-73893	7.775482e-01	0.109
G beta:gamma signalling through CDC42	R-HSA-8964616	7.799166e-01	0.108
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.799166e-01	0.108
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	7.799166e-01	0.108
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	7.799166e-01	0.108
Transcriptional regulation of testis differentiation	R-HSA-9690406	7.799166e-01	0.108
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	7.799166e-01	0.108
Synthesis of PG	R-HSA-1483148	7.799166e-01	0.108
Acetylcholine regulates insulin secretion	R-HSA-399997	7.799166e-01	0.108
Coenzyme A biosynthesis	R-HSA-196783	7.799166e-01	0.108
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	7.799166e-01	0.108
Signaling by Nuclear Receptors	R-HSA-9006931	7.813473e-01	0.107
COPI-mediated anterograde transport	R-HSA-6807878	7.814360e-01	0.107
SARS-CoV Infections	R-HSA-9679506	7.823994e-01	0.107
Effects of PIP2 hydrolysis	R-HSA-114508	7.828093e-01	0.106
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	7.828093e-01	0.106
Regulation of RAS by GAPs	R-HSA-5658442	7.873748e-01	0.104
Signaling by FGFR2 in disease	R-HSA-5655253	7.873748e-01	0.104
PI3K Cascade	R-HSA-109704	7.873748e-01	0.104
G1/S Transition	R-HSA-69206	7.885274e-01	0.103
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	7.910211e-01	0.102
Dual Incision in GG-NER	R-HSA-5696400	7.941794e-01	0.100
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	7.941794e-01	0.100
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	7.941794e-01	0.100
Hyaluronan metabolism	R-HSA-2142845	7.941794e-01	0.100
NPAS4 regulates expression of target genes	R-HSA-9768919	7.941794e-01	0.100
PI3K events in ERBB2 signaling	R-HSA-1963642	7.952328e-01	0.100
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	7.952328e-01	0.100
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	7.952328e-01	0.100
Regulation of FZD by ubiquitination	R-HSA-4641263	7.952328e-01	0.100
Glycogen storage diseases	R-HSA-3229121	7.952328e-01	0.100
Elevation of cytosolic Ca2+ levels	R-HSA-139853	7.952328e-01	0.100
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	7.952328e-01	0.100
Signaling by EGFRvIII in Cancer	R-HSA-5637812	7.952328e-01	0.100
Constitutive Signaling by EGFRvIII	R-HSA-5637810	7.952328e-01	0.100
Uptake and function of anthrax toxins	R-HSA-5210891	7.952328e-01	0.100
Signaling by FGFR	R-HSA-190236	7.957594e-01	0.099
Meiosis	R-HSA-1500620	7.985839e-01	0.098
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.042240e-01	0.095
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	8.050198e-01	0.094
Defects in vitamin and cofactor metabolism	R-HSA-3296482	8.050198e-01	0.094
PERK regulates gene expression	R-HSA-381042	8.050198e-01	0.094
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	8.059294e-01	0.094
RNA Polymerase I Promoter Escape	R-HSA-73772	8.059476e-01	0.094
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	8.059476e-01	0.094
Uptake and actions of bacterial toxins	R-HSA-5339562	8.059476e-01	0.094
Translation	R-HSA-72766	8.078082e-01	0.093
Signaling by ERBB2 ECD mutants	R-HSA-9665348	8.094839e-01	0.092
Transport of connexons to the plasma membrane	R-HSA-190872	8.094839e-01	0.092
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.094839e-01	0.092
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.094839e-01	0.092
FOXO-mediated transcription of cell death genes	R-HSA-9614657	8.094839e-01	0.092
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	8.094839e-01	0.092
Platelet sensitization by LDL	R-HSA-432142	8.094839e-01	0.092
Tie2 Signaling	R-HSA-210993	8.094839e-01	0.092
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	8.094839e-01	0.092
Cyclin E associated events during G1/S transition	R-HSA-69202	8.120883e-01	0.090
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	8.127265e-01	0.090
RUNX2 regulates bone development	R-HSA-8941326	8.153492e-01	0.089
Glycosphingolipid transport	R-HSA-9845576	8.153492e-01	0.089
G1/S-Specific Transcription	R-HSA-69205	8.153492e-01	0.089
FGFR2 mutant receptor activation	R-HSA-1839126	8.153492e-01	0.089
Negative regulation of the PI3K/AKT network	R-HSA-199418	8.184613e-01	0.087
Hedgehog 'on' state	R-HSA-5632684	8.196923e-01	0.086
Cilium Assembly	R-HSA-5617833	8.206335e-01	0.086
Pre-NOTCH Processing in Golgi	R-HSA-1912420	8.227440e-01	0.085
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	8.227440e-01	0.085
PI-3K cascade:FGFR3	R-HSA-5654710	8.227440e-01	0.085
Translesion Synthesis by POLH	R-HSA-110320	8.227440e-01	0.085
Other interleukin signaling	R-HSA-449836	8.227440e-01	0.085
O2/CO2 exchange in erythrocytes	R-HSA-1480926	8.227440e-01	0.085
Rap1 signalling	R-HSA-392517	8.227440e-01	0.085
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	8.227440e-01	0.085
Maturation of nucleoprotein	R-HSA-9694631	8.227440e-01	0.085
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.251863e-01	0.083
TRAF6 mediated IRF7 activation	R-HSA-933541	8.251863e-01	0.083
Degradation of DVL	R-HSA-4641258	8.251863e-01	0.083
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	8.251863e-01	0.083
NCAM1 interactions	R-HSA-419037	8.251863e-01	0.083
Opioid Signalling	R-HSA-111885	8.343964e-01	0.079
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.345494e-01	0.079
PI-3K cascade:FGFR4	R-HSA-5654720	8.350819e-01	0.078
Co-inhibition by CTLA4	R-HSA-389513	8.350819e-01	0.078
Glycogen synthesis	R-HSA-3322077	8.350819e-01	0.078
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.350819e-01	0.078
Signaling by NODAL	R-HSA-1181150	8.350819e-01	0.078
Signaling by FGFR1	R-HSA-5654736	8.390048e-01	0.076
Ion homeostasis	R-HSA-5578775	8.390048e-01	0.076
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	8.390048e-01	0.076
Activation of HOX genes during differentiation	R-HSA-5619507	8.402274e-01	0.076
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	8.402274e-01	0.076
SARS-CoV-2 Infection	R-HSA-9694516	8.409454e-01	0.075
Signaling by NOTCH4	R-HSA-9013694	8.409927e-01	0.075
Stabilization of p53	R-HSA-69541	8.434568e-01	0.074
IRS-mediated signalling	R-HSA-112399	8.464683e-01	0.072
Regulation of CDH1 Function	R-HSA-9764561	8.464683e-01	0.072
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	8.465617e-01	0.072
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.465617e-01	0.072
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.465617e-01	0.072
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.465617e-01	0.072
Basigin interactions	R-HSA-210991	8.465617e-01	0.072
Lagging Strand Synthesis	R-HSA-69186	8.465617e-01	0.072
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	8.465617e-01	0.072
Generation of second messenger molecules	R-HSA-202433	8.519267e-01	0.070
Interleukin-2 family signaling	R-HSA-451927	8.519267e-01	0.070
Potential therapeutics for SARS	R-HSA-9679191	8.529082e-01	0.069
Dual incision in TC-NER	R-HSA-6782135	8.536292e-01	0.069
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.536292e-01	0.069
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	8.572430e-01	0.067
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	8.572430e-01	0.067
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.572430e-01	0.067
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	8.572430e-01	0.067
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	8.572430e-01	0.067
Glutathione synthesis and recycling	R-HSA-174403	8.572430e-01	0.067
Signaling by NTRK3 (TRKC)	R-HSA-9034015	8.572430e-01	0.067
Mitochondrial calcium ion transport	R-HSA-8949215	8.572430e-01	0.067
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.599766e-01	0.066
Maturation of spike protein	R-HSA-9694548	8.599766e-01	0.066
Transcriptional Regulation by VENTX	R-HSA-8853884	8.599766e-01	0.066
FLT3 Signaling	R-HSA-9607240	8.599766e-01	0.066
Regulation of beta-cell development	R-HSA-186712	8.604968e-01	0.065
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	8.624734e-01	0.064
Nuclear Receptor transcription pathway	R-HSA-383280	8.660673e-01	0.062
DNA Replication Pre-Initiation	R-HSA-69002	8.669315e-01	0.062
PI-3K cascade:FGFR1	R-HSA-5654689	8.671814e-01	0.062
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.671814e-01	0.062
Neurotoxicity of clostridium toxins	R-HSA-168799	8.671814e-01	0.062
WNT ligand biogenesis and trafficking	R-HSA-3238698	8.671814e-01	0.062
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.671814e-01	0.062
Ethanol oxidation	R-HSA-71384	8.671814e-01	0.062
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	8.671814e-01	0.062
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	8.671814e-01	0.062
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	8.671814e-01	0.062
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.676242e-01	0.062
Degradation of CRY and PER proteins	R-HSA-9932298	8.676242e-01	0.062
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.676242e-01	0.062
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.676242e-01	0.062
Translation of Structural Proteins	R-HSA-9683701	8.676242e-01	0.062
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	8.681638e-01	0.061
Signaling by Hedgehog	R-HSA-5358351	8.684071e-01	0.061
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.717792e-01	0.060
tRNA processing	R-HSA-72306	8.725473e-01	0.059
MAP kinase activation	R-HSA-450294	8.733876e-01	0.059
Aquaporin-mediated transport	R-HSA-445717	8.733876e-01	0.059
HCMV Infection	R-HSA-9609646	8.740932e-01	0.058
Cleavage of the damaged pyrimidine	R-HSA-110329	8.748862e-01	0.058
Depyrimidination	R-HSA-73928	8.748862e-01	0.058
Interleukin receptor SHC signaling	R-HSA-912526	8.764285e-01	0.057
Organic anion transport by SLCO transporters	R-HSA-879518	8.764285e-01	0.057
Syndecan interactions	R-HSA-3000170	8.764285e-01	0.057
Mitochondrial protein import	R-HSA-1268020	8.794288e-01	0.056
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.794288e-01	0.056
Signaling by PDGF	R-HSA-186797	8.794288e-01	0.056
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	8.794288e-01	0.056
Defective pyroptosis	R-HSA-9710421	8.817793e-01	0.055
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	8.817793e-01	0.055
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	8.850322e-01	0.053
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.850322e-01	0.053
Interleukin-6 family signaling	R-HSA-6783589	8.850322e-01	0.053
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.852123e-01	0.053
G1/S DNA Damage Checkpoints	R-HSA-69615	8.852123e-01	0.053
Signaling by TGF-beta Receptor Complex	R-HSA-170834	8.878650e-01	0.052
EPHB-mediated forward signaling	R-HSA-3928662	8.883197e-01	0.051
Cyclin D associated events in G1	R-HSA-69231	8.883197e-01	0.051
G1 Phase	R-HSA-69236	8.883197e-01	0.051
Regulation of insulin secretion	R-HSA-422356	8.923764e-01	0.049
PI-3K cascade:FGFR2	R-HSA-5654695	8.930375e-01	0.049
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.930375e-01	0.049
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.930375e-01	0.049
Long-term potentiation	R-HSA-9620244	8.930375e-01	0.049
Tight junction interactions	R-HSA-420029	8.930375e-01	0.049
Acyl chain remodelling of PS	R-HSA-1482801	8.930375e-01	0.049
Defects in cobalamin (B12) metabolism	R-HSA-3296469	8.930375e-01	0.049
HDMs demethylate histones	R-HSA-3214842	8.930375e-01	0.049
Laminin interactions	R-HSA-3000157	8.930375e-01	0.049
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.945230e-01	0.048
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.945230e-01	0.048
Fanconi Anemia Pathway	R-HSA-6783310	8.945230e-01	0.048
RAF/MAP kinase cascade	R-HSA-5673001	8.952596e-01	0.048
FOXO-mediated transcription	R-HSA-9614085	8.967303e-01	0.047
TP53 Regulates Metabolic Genes	R-HSA-5628897	8.979899e-01	0.047
Reproduction	R-HSA-1474165	9.002944e-01	0.046
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.004045e-01	0.046
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.004045e-01	0.046
Diseases of DNA repair	R-HSA-9675135	9.004045e-01	0.046
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.004045e-01	0.046
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	9.004857e-01	0.046
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.004857e-01	0.046
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.004857e-01	0.046
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	9.004857e-01	0.046
TRP channels	R-HSA-3295583	9.004857e-01	0.046
Signaling by EGFR in Cancer	R-HSA-1643713	9.004857e-01	0.046
Suppression of phagosomal maturation	R-HSA-9637687	9.004857e-01	0.046
Interleukin-1 signaling	R-HSA-9020702	9.049822e-01	0.043
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.059789e-01	0.043
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.059789e-01	0.043
Synthesis of PC	R-HSA-1483191	9.059789e-01	0.043
Muscle contraction	R-HSA-397014	9.061991e-01	0.043
RNA Polymerase I Promoter Opening	R-HSA-73728	9.074157e-01	0.042
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.074157e-01	0.042
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	9.074157e-01	0.042
Signaling by FGFR3 in disease	R-HSA-5655332	9.074157e-01	0.042
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	9.074157e-01	0.042
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.074157e-01	0.042
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.074157e-01	0.042
Synthesis of PE	R-HSA-1483213	9.074157e-01	0.042
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.103459e-01	0.041
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.105660e-01	0.041
Gluconeogenesis	R-HSA-70263	9.112603e-01	0.040
Metal ion SLC transporters	R-HSA-425410	9.112603e-01	0.040
MAPK1/MAPK3 signaling	R-HSA-5684996	9.127003e-01	0.040
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.138635e-01	0.039
Insulin receptor recycling	R-HSA-77387	9.138635e-01	0.039
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	9.138635e-01	0.039
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.138635e-01	0.039
Pyrimidine salvage	R-HSA-73614	9.138635e-01	0.039
Pyroptosis	R-HSA-5620971	9.138635e-01	0.039
Gap junction trafficking and regulation	R-HSA-157858	9.162626e-01	0.038
Degradation of CDH1	R-HSA-9766229	9.162626e-01	0.038
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	9.162626e-01	0.038
p53-Dependent G1 DNA Damage Response	R-HSA-69563	9.162626e-01	0.038
Signaling by WNT	R-HSA-195721	9.172203e-01	0.038
Interleukin-17 signaling	R-HSA-448424	9.191991e-01	0.037
RSV-host interactions	R-HSA-9833110	9.197748e-01	0.036
Signaling by Erythropoietin	R-HSA-9006335	9.198627e-01	0.036
Signaling by ERBB2 KD Mutants	R-HSA-9664565	9.198627e-01	0.036
Impaired BRCA2 binding to RAD51	R-HSA-9709570	9.198627e-01	0.036
Downstream signaling of activated FGFR3	R-HSA-5654708	9.198627e-01	0.036
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.198627e-01	0.036
DNA methylation	R-HSA-5334118	9.198627e-01	0.036
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.198627e-01	0.036
Platelet calcium homeostasis	R-HSA-418360	9.198627e-01	0.036
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	9.198627e-01	0.036
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.226225e-01	0.035
Downstream signaling of activated FGFR4	R-HSA-5654716	9.254443e-01	0.034
DAP12 signaling	R-HSA-2424491	9.254443e-01	0.034
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.254443e-01	0.034
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	9.254443e-01	0.034
Neurotransmitter clearance	R-HSA-112311	9.254443e-01	0.034
Base Excision Repair	R-HSA-73884	9.254557e-01	0.034
Activation of NF-kappaB in B cells	R-HSA-1169091	9.254822e-01	0.034
Cytosolic sulfonation of small molecules	R-HSA-156584	9.254822e-01	0.034
The phototransduction cascade	R-HSA-2514856	9.254822e-01	0.034
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	9.270647e-01	0.033
Pre-NOTCH Transcription and Translation	R-HSA-1912408	9.288563e-01	0.032
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.297246e-01	0.032
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.297246e-01	0.032
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.306375e-01	0.031
Budding and maturation of HIV virion	R-HSA-162588	9.306375e-01	0.031
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.306375e-01	0.031
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.306375e-01	0.031
Downstream signal transduction	R-HSA-186763	9.306375e-01	0.031
Stimuli-sensing channels	R-HSA-2672351	9.324946e-01	0.030
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	9.337379e-01	0.030
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.337379e-01	0.030
Transmission across Chemical Synapses	R-HSA-112315	9.346328e-01	0.029
HCMV Late Events	R-HSA-9610379	9.348630e-01	0.029
Signaling by Insulin receptor	R-HSA-74752	9.352405e-01	0.029
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.352405e-01	0.029
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.354692e-01	0.029
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	9.354692e-01	0.029
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	9.368668e-01	0.028
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	9.368668e-01	0.028
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	9.368668e-01	0.028
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.375334e-01	0.028
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.375334e-01	0.028
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.375521e-01	0.028
G-protein beta:gamma signalling	R-HSA-397795	9.399647e-01	0.027
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	9.399647e-01	0.027
Cardiogenesis	R-HSA-9733709	9.399647e-01	0.027
Integrin signaling	R-HSA-354192	9.399647e-01	0.027
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.411220e-01	0.026
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.411220e-01	0.026
Signaling by NOTCH3	R-HSA-9012852	9.411220e-01	0.026
Signaling by TGFB family members	R-HSA-9006936	9.417488e-01	0.026
Generic Transcription Pathway	R-HSA-212436	9.434849e-01	0.025
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.437499e-01	0.025
Translation of Structural Proteins	R-HSA-9694635	9.437499e-01	0.025
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.441472e-01	0.025
Acyl chain remodelling of PC	R-HSA-1482788	9.441472e-01	0.025
Vpu mediated degradation of CD4	R-HSA-180534	9.441472e-01	0.025
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.441472e-01	0.025
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	9.445141e-01	0.025
Developmental Cell Lineages	R-HSA-9734767	9.451960e-01	0.024
Cholesterol biosynthesis	R-HSA-191273	9.466301e-01	0.024
MAPK family signaling cascades	R-HSA-5683057	9.469619e-01	0.024
Gap junction assembly	R-HSA-190861	9.480386e-01	0.023
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	9.480386e-01	0.023
Calnexin/calreticulin cycle	R-HSA-901042	9.480386e-01	0.023
NOD1/2 Signaling Pathway	R-HSA-168638	9.480386e-01	0.023
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.480386e-01	0.023
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.480386e-01	0.023
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.480386e-01	0.023
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	9.480386e-01	0.023
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.480386e-01	0.023
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.480386e-01	0.023
Transcriptional regulation by RUNX3	R-HSA-8878159	9.513943e-01	0.022
Downstream signaling of activated FGFR2	R-HSA-5654696	9.516590e-01	0.022
Downstream signaling of activated FGFR1	R-HSA-5654687	9.516590e-01	0.022
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.516590e-01	0.022
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.516590e-01	0.022
Acyl chain remodelling of PE	R-HSA-1482839	9.516590e-01	0.022
Regulation of Apoptosis	R-HSA-169911	9.516590e-01	0.022
Triglyceride metabolism	R-HSA-8979227	9.536085e-01	0.021
MyD88 cascade initiated on plasma membrane	R-HSA-975871	9.536956e-01	0.021
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	9.536956e-01	0.021
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	9.536956e-01	0.021
VEGFA-VEGFR2 Pathway	R-HSA-4420097	9.547498e-01	0.020
GPVI-mediated activation cascade	R-HSA-114604	9.550274e-01	0.020
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.550274e-01	0.020
Lysosome Vesicle Biogenesis	R-HSA-432720	9.550274e-01	0.020
SLC transporter disorders	R-HSA-5619102	9.553773e-01	0.020
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.563097e-01	0.019
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	9.568318e-01	0.019
Degradation of AXIN	R-HSA-4641257	9.581613e-01	0.019
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.581613e-01	0.019
SLC-mediated transport of organic cations	R-HSA-549127	9.581613e-01	0.019
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.588600e-01	0.018
Formation of paraxial mesoderm	R-HSA-9793380	9.588600e-01	0.018
Collagen degradation	R-HSA-1442490	9.588600e-01	0.018
Cytoprotection by HMOX1	R-HSA-9707564	9.590803e-01	0.018
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.591817e-01	0.018
Interleukin-1 family signaling	R-HSA-446652	9.608183e-01	0.017
tRNA processing in the mitochondrion	R-HSA-6785470	9.610770e-01	0.017
MET promotes cell motility	R-HSA-8875878	9.610770e-01	0.017
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.610770e-01	0.017
Platelet activation, signaling and aggregation	R-HSA-76002	9.611987e-01	0.017
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.612672e-01	0.017
PI Metabolism	R-HSA-1483255	9.619316e-01	0.017
DNA Replication	R-HSA-69306	9.623954e-01	0.017
Protein localization	R-HSA-9609507	9.623954e-01	0.017
MAPK6/MAPK4 signaling	R-HSA-5687128	9.632516e-01	0.016
Beta-catenin independent WNT signaling	R-HSA-3858494	9.635933e-01	0.016
Integration of energy metabolism	R-HSA-163685	9.635933e-01	0.016
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.637896e-01	0.016
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.637896e-01	0.016
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.647105e-01	0.016
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.651448e-01	0.015
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.651839e-01	0.015
PPARA activates gene expression	R-HSA-1989781	9.653782e-01	0.015
Glycogen metabolism	R-HSA-8982491	9.663134e-01	0.015
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.663134e-01	0.015
rRNA processing in the mitochondrion	R-HSA-8868766	9.663134e-01	0.015
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.681445e-01	0.014
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.686614e-01	0.014
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.686614e-01	0.014
Hh mutants are degraded by ERAD	R-HSA-5362768	9.686614e-01	0.014
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.686614e-01	0.014
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.686614e-01	0.014
Aflatoxin activation and detoxification	R-HSA-5423646	9.686614e-01	0.014
Chaperonin-mediated protein folding	R-HSA-390466	9.687648e-01	0.014
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	9.687909e-01	0.014
Formation of the cornified envelope	R-HSA-6809371	9.701094e-01	0.013
Interferon gamma signaling	R-HSA-877300	9.707077e-01	0.013
Intra-Golgi traffic	R-HSA-6811438	9.708459e-01	0.013
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.708459e-01	0.013
Scavenging by Class A Receptors	R-HSA-3000480	9.708459e-01	0.013
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.708459e-01	0.013
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.708459e-01	0.013
HDR through Homologous Recombination (HRR)	R-HSA-5685942	9.714094e-01	0.013
Signaling by VEGF	R-HSA-194138	9.727907e-01	0.012
Cytosolic tRNA aminoacylation	R-HSA-379716	9.728782e-01	0.012
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.731047e-01	0.012
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.731587e-01	0.012
Neurotransmitter release cycle	R-HSA-112310	9.734897e-01	0.012
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.744825e-01	0.011
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.747689e-01	0.011
Pyrimidine catabolism	R-HSA-73621	9.747689e-01	0.011
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	9.757449e-01	0.011
MyD88-independent TLR4 cascade	R-HSA-166166	9.757449e-01	0.011
TCR signaling	R-HSA-202403	9.757449e-01	0.011
Neutrophil degranulation	R-HSA-6798695	9.758815e-01	0.011
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.762088e-01	0.010
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.762088e-01	0.010
Gap junction trafficking	R-HSA-190828	9.765280e-01	0.010
DAP12 interactions	R-HSA-2172127	9.765280e-01	0.010
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.765280e-01	0.010
Amine ligand-binding receptors	R-HSA-375280	9.765280e-01	0.010
Proteasome assembly	R-HSA-9907900	9.765280e-01	0.010
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.765280e-01	0.010
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.775311e-01	0.010
Protein folding	R-HSA-391251	9.775311e-01	0.010
Regulation of mitotic cell cycle	R-HSA-453276	9.776279e-01	0.010
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	9.776279e-01	0.010
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.776279e-01	0.010
Viral Infection Pathways	R-HSA-9824446	9.780167e-01	0.010
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.781645e-01	0.010
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.781645e-01	0.010
Platelet Aggregation (Plug Formation)	R-HSA-76009	9.781645e-01	0.010
Somitogenesis	R-HSA-9824272	9.781645e-01	0.010
ER to Golgi Anterograde Transport	R-HSA-199977	9.786358e-01	0.009
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.787427e-01	0.009
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.789650e-01	0.009
Purine catabolism	R-HSA-74259	9.789650e-01	0.009
Neddylation	R-HSA-8951664	9.790707e-01	0.009
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.791889e-01	0.009
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.791889e-01	0.009
Condensation of Prophase Chromosomes	R-HSA-2299718	9.796870e-01	0.009
Regulation of pyruvate metabolism	R-HSA-9861718	9.796870e-01	0.009
Ca2+ pathway	R-HSA-4086398	9.802244e-01	0.009
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.809816e-01	0.008
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	9.821680e-01	0.008
Intraflagellar transport	R-HSA-5620924	9.824212e-01	0.008
Co-stimulation by CD28	R-HSA-389356	9.824212e-01	0.008
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.825277e-01	0.008
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.829943e-01	0.007
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.829995e-01	0.007
Interferon alpha/beta signaling	R-HSA-909733	9.830680e-01	0.007
G alpha (s) signalling events	R-HSA-418555	9.832609e-01	0.007
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.836471e-01	0.007
Chemokine receptors bind chemokines	R-HSA-380108	9.836471e-01	0.007
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.847876e-01	0.007
Post-translational protein phosphorylation	R-HSA-8957275	9.848022e-01	0.007
SLC-mediated transport of organic anions	R-HSA-9955298	9.855014e-01	0.006
Complex IV assembly	R-HSA-9864848	9.858486e-01	0.006
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.858486e-01	0.006
Hedgehog ligand biogenesis	R-HSA-5358346	9.858486e-01	0.006
Transcriptional regulation by RUNX2	R-HSA-8878166	9.862553e-01	0.006
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	9.862553e-01	0.006
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	9.862553e-01	0.006
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.863785e-01	0.006
Amino acids regulate mTORC1	R-HSA-9639288	9.877540e-01	0.005
Regulation of PTEN stability and activity	R-HSA-8948751	9.877540e-01	0.005
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.880541e-01	0.005
Parasite infection	R-HSA-9664407	9.880541e-01	0.005
Leishmania phagocytosis	R-HSA-9664417	9.880541e-01	0.005
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	9.882623e-01	0.005
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	9.882623e-01	0.005
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.886331e-01	0.005
Co-inhibition by PD-1	R-HSA-389948	9.889719e-01	0.005
Neuronal System	R-HSA-112316	9.892689e-01	0.005
G alpha (z) signalling events	R-HSA-418597	9.894030e-01	0.005
Paracetamol ADME	R-HSA-9753281	9.894030e-01	0.005
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.901423e-01	0.004
Signaling by NOTCH	R-HSA-157118	9.901428e-01	0.004
Dectin-2 family	R-HSA-5621480	9.908301e-01	0.004
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.910008e-01	0.004
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.914700e-01	0.004
Nucleotide catabolism	R-HSA-8956319	9.923383e-01	0.003
tRNA Aminoacylation	R-HSA-379724	9.926189e-01	0.003
Glutathione conjugation	R-HSA-156590	9.926189e-01	0.003
Metabolism of polyamines	R-HSA-351202	9.926189e-01	0.003
Signaling by Retinoic Acid	R-HSA-5362517	9.926189e-01	0.003
Nucleotide salvage	R-HSA-8956321	9.931341e-01	0.003
Cellular response to chemical stress	R-HSA-9711123	9.931817e-01	0.003
Downstream TCR signaling	R-HSA-202424	9.936063e-01	0.003
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.936133e-01	0.003
Degradation of the extracellular matrix	R-HSA-1474228	9.938278e-01	0.003
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.943047e-01	0.002
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.944737e-01	0.002
Ion transport by P-type ATPases	R-HSA-936837	9.944737e-01	0.002
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.945939e-01	0.002
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.952184e-01	0.002
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.954490e-01	0.002
Hemostasis	R-HSA-109582	9.955443e-01	0.002
Nicotinate metabolism	R-HSA-196807	9.955522e-01	0.002
Regulated Necrosis	R-HSA-5218859	9.958627e-01	0.002
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.961710e-01	0.002
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.966231e-01	0.001
ECM proteoglycans	R-HSA-3000178	9.966703e-01	0.001
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.966703e-01	0.001
Metabolism of cofactors	R-HSA-8978934	9.966703e-01	0.001
Disorders of transmembrane transporters	R-HSA-5619115	9.968312e-01	0.001
ABC-family proteins mediated transport	R-HSA-382556	9.970347e-01	0.001
Diseases of carbohydrate metabolism	R-HSA-5663084	9.971191e-01	0.001
Extra-nuclear estrogen signaling	R-HSA-9009391	9.972199e-01	0.001
Ion channel transport	R-HSA-983712	9.973001e-01	0.001
ROS and RNS production in phagocytes	R-HSA-1222556	9.973203e-01	0.001
Citric acid cycle (TCA cycle)	R-HSA-71403	9.975075e-01	0.001
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.977162e-01	0.001
C-type lectin receptors (CLRs)	R-HSA-5621481	9.978218e-01	0.001
Cytokine Signaling in Immune system	R-HSA-1280215	9.978322e-01	0.001
Regulation of T cell activation by CD28 family	R-HSA-388841	9.978931e-01	0.001
ABC transporter disorders	R-HSA-5619084	9.979942e-01	0.001
Integrin cell surface interactions	R-HSA-216083	9.979942e-01	0.001
Platelet homeostasis	R-HSA-418346	9.981147e-01	0.001
Antigen processing-Cross presentation	R-HSA-1236975	9.983445e-01	0.001
Cardiac conduction	R-HSA-5576891	9.983510e-01	0.001
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.986036e-01	0.001
Transport to the Golgi and subsequent modification	R-HSA-948021	9.986119e-01	0.001
FCERI mediated MAPK activation	R-HSA-2871796	9.987244e-01	0.001
Pyruvate metabolism	R-HSA-70268	9.990280e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.990802e-01	0.000
ER-Phagosome pathway	R-HSA-1236974	9.991592e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.992180e-01	0.000
Toll-like Receptor Cascades	R-HSA-168898	9.992638e-01	0.000
Leishmania infection	R-HSA-9658195	9.993475e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.993475e-01	0.000
Signaling by Interleukins	R-HSA-449147	9.993776e-01	0.000
FCGR activation	R-HSA-2029481	9.994148e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.994846e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.994846e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.994938e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.995585e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.995621e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.996221e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.996478e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.996691e-01	0.000
Keratinization	R-HSA-6805567	9.996982e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.997365e-01	0.000
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.997454e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.997847e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.998525e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.998629e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.998970e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999113e-01	0.000
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.999130e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999157e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999311e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999490e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999497e-01	0.000
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.999694e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999760e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999827e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999842e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999866e-01	0.000
Infectious disease	R-HSA-5663205	9.999870e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999922e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999938e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999955e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999965e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999972e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999974e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999980e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999986e-01	0.000
Adaptive Immune System	R-HSA-1280218	9.999993e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999994e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999996e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999996e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999999e-01	0.000
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
G alpha (q) signalling events	R-HSA-416476	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Innate Immune System	R-HSA-168249	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Immune System	R-HSA-168256	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000