MEK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O00170 T48 Sugiyama AIP XAP2 FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF
O14818 T152 Sugiyama PSMA7 HSPC LIVGFDFDGTPRLyQtDPsGtyHAWKANAIGRGAKSVREFL
O14979 T165 Sugiyama HNRNPDL HNRPDL JKTBP QDDGKMFIGGLSWDTsKKDLtEyLSRFGEVVDCtIKTDPVT
O15042 S485 Sugiyama U2SURP KIAA0332 SR140 NQTPAHVYYRWKLYsILQGDsPtKWRTEDFRMFKNGSFWRP
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O94826 S91 Sugiyama TOMM70 KIAA0719 TOM70 TOMM70A RGDASGLKRNSERKtPEGRAsPAPGsGHPEGPGAHLDMNsL
O95273 S313 GPS6 CCNDBP1 DIP1 GCIP HHM LSIYPPMCHLTVRINSAKLVsVLKKALEITKASHVTPQPED
O95273 S356 GPS6 CCNDBP1 DIP1 GCIP HHM IPLLINAIDHCMNRIKELTQsELEL________________
O95373 T968 Sugiyama IPO7 RANBP7 IIDDEDNPVDEYQIFKAIFQtIQNRNPVWyQALTHGLNEEQ
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04049 T638 Sugiyama RAF1 RAF RsAsEPsLHRAAHtEDINACtLttsPRLPVF__________
P04049 T640 Sugiyama RAF1 RAF AsEPsLHRAAHtEDINACtLttsPRLPVF____________
P04049 T641 Sugiyama RAF1 RAF sEPsLHRAAHtEDINACtLttsPRLPVF_____________
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075 T49 Sugiyama ALDOA ALDA GILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtADDR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T246 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05455 T120 Sugiyama SSB VTDEyKNDVKNRsVYIKGFPtDAtLDDIKEWLEDKGQVLNI
P05787 S74 EPSD|PSP KRT8 CYK8 YGGASGMGGITAVtVNQSLLsPLVLEVDPNIQAVRTQEKEQ
P06733 T100 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 KKLNVtEQEKIDKLMIEMDGtENKsKFGANAILGVsLAVCK
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 T18 Sugiyama LDHB ___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07237 T453 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB EAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKFLESG
P07437 T35 Sugiyama TUBB TUBB5 OK/SW-cl.56 QIGAKFWEVISDEHGIDPTGtyHGDsDLQLDRIsVyyNEAt
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0DPH7 T51 Sugiyama TUBA3C TUBA2 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P10809 T422 Sugiyama HSPD1 HSP60 AVLKVGGtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGC
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T38 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P13987 T76 Sugiyama CD59 MIC11 MIN1 MIN2 MIN3 MSK21 AGLQVYNKCWKFEHCNFNDVtTRLRENELtyyCCKKDLCNF
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P14625 T148 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GNEELTVKIKCDKEKNLLHVtDtGVGMtREELVKNLGTIAK
P14625 T519 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17542 S122 SIGNOR TAL1 BHLHA17 SCL TCL5 APAPASVTAELPGDGRMVQLsPPALAAPAAPGRALLYSLSQ
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18669 Y26 Sugiyama PGAM1 PGAMA CDABP0006 LVLIRHGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALR
P21333 S1084 Sugiyama FLNA FLN FLN1 PTKPSKVKAFGPGLQGGsAGsPARFtIDTKGAGTGGLGLTV
P21980 T368 Sugiyama TGM2 QPGYEGWQALDPTPQEKsEGtyCCGPVPVRAIKEGDLstKy
P22059 S190 Sugiyama OSBP OSBP1 QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23381 T362 Sugiyama WARS1 IFI53 WARS WRS ALQGAQTKMsAsDPNssIFLtDtAKQIKTKVNKHAFsGGRD
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P24752 T185 Sugiyama ACAT1 ACAT MAT RGSTPYGGVKLEDLIVKDGLtDVyNKIHMGsCAENTAKKLN
P25786 T11 Sugiyama PSMA1 HC2 NU PROS30 PSC2 __________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27361 T202 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK3 ERK1 PRKM3 ICDFGLARIADPEHDHtGFLtEyVAtRWyRAPEIMLNSKGY
P27361 Y204 SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK3 ERK1 PRKM3 DFGLARIADPEHDHtGFLtEyVAtRWyRAPEIMLNSKGYTK
P28482 T185 GPS6|SIGNOR|ELM|EPSD MAPK1 ERK2 PRKM1 PRKM2 ICDFGLARVADPDHDHtGFLtEyVAtRWyRAPEIMLNSKGY
P28482 Y187 SIGNOR MAPK1 ERK2 PRKM1 PRKM2 DFGLARVADPDHDHtGFLtEyVAtRWyRAPEIMLNSKGYTK
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P30086 T167 Sugiyama PEBP1 PBP PEBP GKFKVAsFRKKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK
P30101 Y115 Sugiyama PDIA3 ERP57 ERP60 GRP58 yGVsGyPtLKIFRDGEEAGAyDGPRtADGIVsHLKKQAGPA
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931 T40 Sugiyama HSPA1L VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269 T156 Sugiyama GTF2F1 RAP74 EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35269 T41 Sugiyama GTF2F1 RAP74 NTTKKyNIMAFNAADKVNFAtWNQARLERDLSNKKIyQEEE
P35568 S307 SIGNOR IRS1 HHLNNPPPSQVGLTRRsRtEsItAtsPAsMVGGKPGsFRVR
P36507 S222 Sugiyama MAP2K2 MEK2 MKK2 PRKMK2 VNSRGEIKLCDFGVsGQLIDsMANsFVGtRSYMAPERLQGT
P36507 S226 iPTMNet|EPSD|Sugiyama MAP2K2 MEK2 MKK2 PRKMK2 GEIKLCDFGVsGQLIDsMANsFVGtRSYMAPERLQGTHYSV
P36507 S26 iPTMNet|EPSD MAP2K2 MEK2 MKK2 PRKMK2 KPVLPALTINPtIAEGPsPtsEGAsEANLVDLQKKLEELEL
P36507 T396 iPTMNet|EPSD MAP2K2 MEK2 MKK2 PRKMK2 EVDFAGWLCKTLRLNQPGtPtRtAV________________
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P38646 T87 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P41091 T21 Sugiyama EIF2S3 EIF2G MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P42166 S159 Sugiyama TMPO LAP2 RKLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsND
P42166 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167 S159 Sugiyama TMPO LAP2 RKLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSND
P42167 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43034 T150 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA ATIKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSA
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P45984 S407 ELM MAPK9 JNK2 PRKM9 SAPK1A PSQSSSINDISSMSTEQtLAsDTDSSLDASTGPLEGCR___
P45984 T404 ELM MAPK9 JNK2 PRKM9 SAPK1A NATPSQSSSINDISSMSTEQtLAsDTDSSLDASTGPLEGCR
P46937 S109 Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P47712 S724 Sugiyama PLA2G4A CPLA2 PLA2G4 NIDVIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFL
P47756 T202 Sugiyama CAPZB SGsGtMNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMEN
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 Y216 SIGNOR|Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P51149 T168 Sugiyama RAB7A RAB7 NIPyFEtSAKEAINVEQAFQtIARNALKQETEVELyNEFPE
P53779 T221 ELM MAPK10 JNK3 JNK3A PRKM10 SAPK1B CTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYK
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T39 Sugiyama HSPA2 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P55036 T264 Sugiyama PSMD4 MCB1 AEAGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEE
P55211 T125 SIGNOR|iPTMNet|EPSD CASP9 MCH6 NLtPVVLRPEIRKPEVLRPEtPRPVDIGSGGFGDVGALEsL
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60660 T103 Sugiyama MYL6 QGtyEDyVEGLRVFDKEGNGtVMGAEIRHVLVtLGEKMTEE
P60660 T85 Sugiyama MYL6 LDFEHFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVM
P60660 Y89 Sugiyama MYL6 HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P60709 T201 Sugiyama ACTB AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL
P60709 T202 Sugiyama ACTB GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62942 T28 Sugiyama FKBP1A FKBP1 FKBP12 IsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPFK
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63220 T52 Sugiyama RPS21 IQMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRL
P63261 T201 Sugiyama ACTG1 ACTG AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL
P63261 T202 Sugiyama ACTG1 ACTG GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68104 T261 Sugiyama EEF1A1 EEF1A EF1A LENG7 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
P68363 T51 Sugiyama TUBA1B QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P78527 T2645 Sugiyama PRKDC HYRC HYRC1 LSARWPVAGQIRAtQQQHDFtLtQtADGRssFDWLTGsstD
P78527 T2647 Sugiyama PRKDC HYRC HYRC1 ARWPVAGQIRAtQQQHDFtLtQtADGRssFDWLTGsstDPL
P98179 Y118 Sugiyama RBM3 RNPL GRGRSYSRGGGDQGYGSGRyyDsRPGGyGyGyGRSRDYNGR
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q00613 T349 Sugiyama HSF1 HSTF1 ALIDsILREsEPAPAsVTALtDARGHTDtEGRPPsPPPtst
Q00613 T357 Sugiyama HSF1 HSTF1 EsEPAPAsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVA
Q00613 T369 Sugiyama HSF1 HSTF1 tDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLD
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q02750 S218 ELM|Sugiyama MAP2K1 MEK1 PRKMK1 VNSRGEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGT
Q02750 S222 Sugiyama MAP2K1 MEK1 PRKMK1 GEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGTHYSV
Q02750 S24 ELM MAP2K1 MEK1 PRKMK1 KKPTPIQLNPAPDGSAVNGtssAETNLEALQKKLEELELDE
Q02750 S25 ELM MAP2K1 MEK1 PRKMK1 KPTPIQLNPAPDGSAVNGtssAETNLEALQKKLEELELDEQ
Q02750 S298 ELM MAP2K1 MEK1 PRKMK1 QVEGDAAEtPPRPRtPGRPLssyGMDsRPPMAIFELLDYIV
Q02750 T23 ELM MAP2K1 MEK1 PRKMK1 KKKPTPIQLNPAPDGSAVNGtssAETNLEALQKKLEELELD
Q05639 T261 Sugiyama EEF1A2 EEF1AL STN PTDKPLRLPLQDVyKIGGIGtVPVGRVETGILRPGMVVTFA
Q06830 T166 Sugiyama PRDX1 PAGA PAGB TDPX2 DLPVGRsVDEtLRLVQAFQFtDKHGEVCPAGWKPGsDtIKP
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q07666 S20 Sugiyama KHDRBS1 SAM68 _MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q12906 T300 Sugiyama ILF3 DRBF MPHOSPH4 NF90 ASGIVMPDGSGIYDPCEKEAtDAIGHLDRQQREDItQsAQH
Q13009 S329 SIGNOR TIAM1 SNsMQGRRAKttQDVNAGEGsEFADsGIEGAtTDTDLLSRR
Q13247 S303 Sugiyama SRSF6 SFRS6 SRP55 ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283 S231 Sugiyama G3BP1 G3BP QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q13283 T241 Sugiyama G3BP1 G3BP ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q15056 T100 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 KFKGFCyVEFDEVDsLKEALtyDGALLGDRsLRVDIAEGRK
Q15293 S69 Sugiyama RCN1 RCN PPEDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVD
Q15293 T100 Sugiyama RCN1 RCN sKERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNV
Q15293 T71 Sugiyama RCN1 RCN EDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRI
Q15427 T14 Sugiyama SF3B4 SAP49 _______MAAGPISERNQDAtVyVGGLDEKVSEPLLWELFL
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q16539 T180 ELM MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A EDCELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHY
Q16539 Y182 ELM MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A CELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHYNQ
Q2VIR3 T21 Sugiyama EIF2S3B MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q53EL6 S94 Sugiyama PDCD4 H731 GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q53EL6 T93 Sugiyama PDCD4 H731 RGDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLP
Q562R1 T107 Sugiyama ACTBL2 WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q5VTE0 T261 Sugiyama EEF1A1P5 EEF1AL3 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
Q6GYQ0 S1000 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 VATITGSESASPVHSPLGSRsQtPsPSTLNIDHMEQKDLQL
Q6PEY2 T51 Sugiyama TUBA3E QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6PKG0 T747 Sugiyama LARP1 KIAA0731 LARP PPVDPNQEVPPGPPRFQQVPtDALANKLFGAPEPstIARsL
Q6UN15 S492 Sugiyama FIP1L1 FIP1 RHE DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15 T494 Sugiyama FIP1L1 FIP1 RHE DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q71U36 T51 Sugiyama TUBA1A TUBA3 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q7L2J0 S216 Sugiyama MEPCE BCDIN3 NLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDIt
Q7L2J0 S217 Sugiyama MEPCE BCDIN3 LNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDItD
Q7L2J0 S69 Sugiyama MEPCE BCDIN3 RGPGRCAPsAGsPAAAVGREsPGAAAtsSSGPQAQQHRGGG
Q7L2J0 T213 Sugiyama MEPCE BCDIN3 DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q8IWX8 S815 Sugiyama CHERP DAN26 SCAF6 RSQSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIP
Q8IWX8 S817 Sugiyama CHERP DAN26 SCAF6 QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8 T819 Sugiyama CHERP DAN26 SCAF6 RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8N684 S205 Sugiyama CPSF7 IPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLPYF
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8NBS9 T248 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 EQLALGLEHSETVKIGKVDCtQHyELCsGNQVRGyPtLLWF
Q96AE4 Y625 Sugiyama FUBP1 PGGQPDYSAAWAEYYRQQAAyyAQtsPQGMPQHPPAPQGQ_
Q99733 T28 Sugiyama NAP1L4 NAP2 DGVPsDsVEAAKNAsNtEKLtDQVMQNPRVLAALQERLDNV
Q9BQ70 T86 Sugiyama TCF25 KIAA1049 NULP1 FKSG26 NIDDLEDDPVVNGERsGCALtDAVAPGNKGRGQRGNtEsKt
Q9BQE3 T51 Sugiyama TUBA1C TUBA6 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BTA9 S525 Sugiyama WAC KIAA1844 QGHEPVsPRSLQRsssQRsPsPGPNHtsNssNAsNATVVPQ
Q9C0C2 S672 Sugiyama TNKS1BP1 KIAA1741 TAB182 TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H2H8 T153 Sugiyama PPIL3 KLPVNEKtyRPLNDVHIKDItIHANPFAQ____________
Q9H6F5 S91 Sugiyama CCDC86 CYCLON RLQQGAGLEsPQGQPEPGAAsPQRQQDLHLEsPQRQPEysP
Q9H7N4 S498 Sugiyama SCAF1 SFRS19 SRA1 GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4 S500 Sugiyama SCAF1 SFRS19 SRA1 LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9NZZ3 S16 Sugiyama CHMP5 C9orf83 SNF7DC2 CGI-34 HSPC177 PNAS-114 PNAS-2 _____MNRLFGKAKPKAPPPsLtDCIGtVDsRAEsIDKKIS
Q9NZZ3 T18 Sugiyama CHMP5 C9orf83 SNF7DC2 CGI-34 HSPC177 PNAS-114 PNAS-2 ___MNRLFGKAKPKAPPPsLtDCIGtVDsRAEsIDKKISRL
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S1648 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35 S1652 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 LPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTARRGs
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ35 S876 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 tsPQANEQsVtPQRRsCFEssPDPELKsRtPsRHsCsGssP
Q9Y2B0 S74 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 GsFRINPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGE
Q9Y2V2 S30 Sugiyama CARHSP1 QPPtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRt
Q9Y2V2 S32 Sugiyama CARHSP1 PtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRtFs
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Interleukin-37 signaling R-HSA-9008059 1.026016e-07 6.989 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.953641e-07 6.403 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.633311e-06 5.579 0 0
RAB geranylgeranylation R-HSA-8873719 2.742024e-06 5.562 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.416919e-06 5.466 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.949613e-06 5.403 0 0
Cell Cycle R-HSA-1640170 1.130887e-05 4.947 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.441593e-05 4.612 0 0
Selective autophagy R-HSA-9663891 3.438548e-05 4.464 0 0
Aggrephagy R-HSA-9646399 5.441957e-05 4.264 0 0
Regulation of TP53 Activity R-HSA-5633007 5.487753e-05 4.261 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.294616e-05 4.201 0 0
Mitotic Prometaphase R-HSA-68877 8.586249e-05 4.066 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.805656e-05 4.108 0 0
Separation of Sister Chromatids R-HSA-2467813 7.459363e-05 4.127 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.277952e-05 4.082 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.377448e-04 3.861 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.398676e-04 3.854 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.571886e-04 3.804 0 0
Neutrophil degranulation R-HSA-6798695 1.902000e-04 3.721 0 0
Membrane Trafficking R-HSA-199991 2.027591e-04 3.693 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.346692e-04 3.630 0 0
Cellular Senescence R-HSA-2559583 2.469663e-04 3.607 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.191550e-04 3.659 0 0
Kinesins R-HSA-983189 2.537583e-04 3.596 0 0
Cell Cycle, Mitotic R-HSA-69278 2.453407e-04 3.610 0 0
M Phase R-HSA-68886 2.676494e-04 3.572 0 0
Rab regulation of trafficking R-HSA-9007101 2.801733e-04 3.553 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.014268e-04 3.521 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.231387e-04 3.491 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.099216e-04 3.387 0 0
Diseases of programmed cell death R-HSA-9645723 4.354721e-04 3.361 0 0
Signaling by Hippo R-HSA-2028269 4.714890e-04 3.327 0 0
TBC/RABGAPs R-HSA-8854214 4.912353e-04 3.309 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.103972e-04 3.292 0 0
Platelet sensitization by LDL R-HSA-432142 5.936036e-04 3.227 0 0
Oncogene Induced Senescence R-HSA-2559585 6.118527e-04 3.213 0 0
Interleukin-1 family signaling R-HSA-446652 6.401563e-04 3.194 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.113982e-04 3.148 0 0
Cell Cycle Checkpoints R-HSA-69620 6.976345e-04 3.156 0 0
Generic Transcription Pathway R-HSA-212436 8.114208e-04 3.091 0 0
Autophagy R-HSA-9612973 8.307019e-04 3.081 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.057474e-03 2.976 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.075101e-03 2.969 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.075101e-03 2.969 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.075101e-03 2.969 0 0
Cell-Cell communication R-HSA-1500931 1.078552e-03 2.967 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.008912e-03 2.996 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.008912e-03 2.996 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.004325e-03 2.998 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.495529e-04 3.022 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.174420e-03 2.930 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.135009e-03 2.945 0 0
Post NMDA receptor activation events R-HSA-438064 1.281226e-03 2.892 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.373517e-03 2.862 0 0
Cellular responses to stimuli R-HSA-8953897 1.354899e-03 2.868 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.395945e-03 2.855 0 0
Notch-HLH transcription pathway R-HSA-350054 1.611595e-03 2.793 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.556830e-03 2.808 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.592623e-03 2.798 1 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.615894e-03 2.792 0 0
Cellular responses to stress R-HSA-2262752 1.626475e-03 2.789 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.844402e-03 2.734 0 0
Cell junction organization R-HSA-446728 1.782396e-03 2.749 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.844402e-03 2.734 0 0
Macroautophagy R-HSA-1632852 1.944508e-03 2.711 0 0
Immune System R-HSA-168256 1.932421e-03 2.714 0 0
PKR-mediated signaling R-HSA-9833482 2.005072e-03 2.698 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.122423e-03 2.673 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.089832e-03 2.680 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.140569e-03 2.669 0 0
Mitotic Anaphase R-HSA-68882 2.037888e-03 2.691 0 0
RAF activation R-HSA-5673000 2.431753e-03 2.614 1 1
Innate Immune System R-HSA-168249 2.377264e-03 2.624 0 0
Gap junction assembly R-HSA-190861 2.431753e-03 2.614 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.917435e-03 2.535 1 1
Signaling downstream of RAS mutants R-HSA-9649948 2.917435e-03 2.535 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.917435e-03 2.535 1 1
Condensation of Prophase Chromosomes R-HSA-2299718 2.917435e-03 2.535 0 0
Signaling by RAS mutants R-HSA-6802949 2.917435e-03 2.535 1 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.886174e-03 2.540 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.881972e-03 2.540 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.582532e-03 2.446 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.582532e-03 2.446 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.761413e-03 2.425 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.570553e-03 2.447 1 1
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.761413e-03 2.425 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.316569e-03 2.479 0 0
RNA Polymerase II Transcription R-HSA-73857 3.607319e-03 2.443 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.544859e-03 2.450 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.106068e-03 2.387 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.529212e-03 2.344 0 0
Signaling by Interleukins R-HSA-449147 4.680697e-03 2.330 0 0
G2/M Transition R-HSA-69275 4.687037e-03 2.329 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.711450e-03 2.327 0 0
Interferon alpha/beta signaling R-HSA-909733 5.129278e-03 2.290 0 0
Adherens junctions interactions R-HSA-418990 4.788993e-03 2.320 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.160642e-03 2.287 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.172382e-03 2.286 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.187504e-03 2.285 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.437751e-03 2.265 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.454510e-03 2.263 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.670320e-03 2.246 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.650864e-03 2.248 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.670320e-03 2.246 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.093853e-03 2.215 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.315548e-03 2.200 1 1
MAP2K and MAPK activation R-HSA-5674135 6.315548e-03 2.200 1 1
Negative regulation of MAPK pathway R-HSA-5675221 6.315548e-03 2.200 1 0
ER to Golgi Anterograde Transport R-HSA-199977 6.929007e-03 2.159 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.938371e-03 2.159 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 7.832495e-03 2.106 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.917036e-03 2.101 0 0
Signal Transduction R-HSA-162582 7.798055e-03 2.108 1 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.133812e-03 2.090 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 8.341277e-03 2.079 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.498239e-03 2.071 0 0
Gap junction trafficking R-HSA-190828 8.580205e-03 2.067 0 0
Meiosis R-HSA-1500620 8.673711e-03 2.062 0 0
Cell-cell junction organization R-HSA-421270 9.324062e-03 2.030 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.471714e-03 2.024 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 9.963915e-03 2.002 0 0
Vesicle-mediated transport R-HSA-5653656 9.530917e-03 2.021 0 0
Diseases of DNA repair R-HSA-9675135 1.038930e-02 1.983 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.850805e-03 2.007 0 0
Hedgehog 'off' state R-HSA-5610787 1.073070e-02 1.969 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.098751e-02 1.959 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.139112e-02 1.943 0 0
Recycling pathway of L1 R-HSA-437239 1.139112e-02 1.943 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.353165e-02 1.869 0 0
Regulation of TP53 Expression R-HSA-6804754 1.353165e-02 1.869 0 0
Diseases of cellular response to stress R-HSA-9675132 1.353165e-02 1.869 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.353165e-02 1.869 0 0
C6 deamination of adenosine R-HSA-75102 1.353165e-02 1.869 0 0
HDMs demethylate histones R-HSA-3214842 1.232967e-02 1.909 0 0
Co-stimulation by CD28 R-HSA-389356 1.246106e-02 1.904 0 0
Intraflagellar transport R-HSA-5620924 1.246106e-02 1.904 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.284685e-02 1.891 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.360151e-02 1.866 0 0
Gap junction trafficking and regulation R-HSA-157858 1.360151e-02 1.866 0 0
Myogenesis R-HSA-525793 1.395642e-02 1.855 0 0
Disorders of Developmental Biology R-HSA-9675151 1.416777e-02 1.849 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.475076e-02 1.831 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.548393e-02 1.810 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.572152e-02 1.804 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.611028e-02 1.793 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.615785e-02 1.792 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.906437e-02 1.720 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.719071e-02 1.765 0 0
Gene expression (Transcription) R-HSA-74160 1.773696e-02 1.751 0 0
Smooth Muscle Contraction R-HSA-445355 1.891499e-02 1.723 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.777105e-02 1.750 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.704509e-02 1.768 0 0
Signaling by ALK in cancer R-HSA-9700206 1.704509e-02 1.768 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.968457e-02 1.706 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.990324e-02 1.701 0 0
FLT3 Signaling R-HSA-9607240 1.996059e-02 1.700 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.054898e-02 1.687 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.083803e-02 1.681 0 0
Interferon Signaling R-HSA-913531 2.097696e-02 1.678 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.185934e-02 1.660 0 0
Signaling by NOTCH3 R-HSA-9012852 2.205369e-02 1.657 0 0
Signaling by NOTCH R-HSA-157118 2.212274e-02 1.655 0 0
Programmed Cell Death R-HSA-5357801 2.229163e-02 1.652 0 0
NRAGE signals death through JNK R-HSA-193648 2.375082e-02 1.624 0 0
PECAM1 interactions R-HSA-210990 2.408600e-02 1.618 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.741016e-02 1.562 0 0
Signaling by WNT in cancer R-HSA-4791275 2.676980e-02 1.572 0 0
Defective pyroptosis R-HSA-9710421 2.582006e-02 1.588 0 0
Regulation of CDH1 Function R-HSA-9764561 2.553570e-02 1.593 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.785328e-02 1.555 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.699369e-02 1.569 0 0
Interleukin-12 family signaling R-HSA-447115 2.699369e-02 1.569 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.761126e-02 1.559 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.870611e-02 1.542 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.870611e-02 1.542 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.876196e-02 1.541 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.876196e-02 1.541 0 0
Pervasive developmental disorders R-HSA-9005895 3.376090e-02 1.472 0 0
Disorders of Nervous System Development R-HSA-9697154 3.376090e-02 1.472 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.376090e-02 1.472 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.376090e-02 1.472 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.376090e-02 1.472 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.376090e-02 1.472 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.376090e-02 1.472 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.376090e-02 1.472 0 0
Striated Muscle Contraction R-HSA-390522 3.229163e-02 1.491 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.937594e-02 1.532 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.944905e-02 1.531 0 0
Regulation of IFNG signaling R-HSA-877312 3.376090e-02 1.472 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.376090e-02 1.472 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.143470e-02 1.503 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.143470e-02 1.503 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.143470e-02 1.503 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.143470e-02 1.503 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.143470e-02 1.503 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 3.376090e-02 1.472 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.301648e-02 1.481 0 0
Signaling by NOTCH1 R-HSA-1980143 3.310559e-02 1.480 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.143470e-02 1.503 0 0
Co-inhibition by PD-1 R-HSA-389948 3.372974e-02 1.472 0 0
L1CAM interactions R-HSA-373760 2.978693e-02 1.526 1 0
Interleukin-12 signaling R-HSA-9020591 3.310559e-02 1.480 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.529976e-02 1.452 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.529976e-02 1.452 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.529976e-02 1.452 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.529976e-02 1.452 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.529976e-02 1.452 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.544883e-02 1.450 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.575768e-02 1.447 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 4.265908e-02 1.370 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 4.265908e-02 1.370 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 4.265908e-02 1.370 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 4.265908e-02 1.370 0 0
Defective OGG1 Localization R-HSA-9657050 4.265908e-02 1.370 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 4.265908e-02 1.370 0 0
Activation of AKT2 R-HSA-165158 3.805611e-02 1.420 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.924533e-02 1.406 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.317395e-02 1.365 1 1
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.715572e-02 1.430 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.016883e-02 1.396 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.172105e-02 1.380 0 0
GPVI-mediated activation cascade R-HSA-114604 4.181984e-02 1.379 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 3.805611e-02 1.420 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.805611e-02 1.420 0 0
Protein folding R-HSA-391251 3.733506e-02 1.428 0 0
Cilium Assembly R-HSA-5617833 4.408603e-02 1.356 0 0
Signaling by Hedgehog R-HSA-5358351 4.232919e-02 1.373 0 0
Interleukin-6 signaling R-HSA-1059683 3.924533e-02 1.406 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.425960e-02 1.354 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.425960e-02 1.354 0 0
Death Receptor Signaling R-HSA-73887 4.172105e-02 1.380 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 3.805611e-02 1.420 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.847531e-02 1.415 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.387042e-02 1.358 0 0
Co-inhibition by BTLA R-HSA-9927353 3.805611e-02 1.420 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.946122e-02 1.404 0 0
MHC class II antigen presentation R-HSA-2132295 4.079671e-02 1.389 0 0
Toll-like Receptor Cascades R-HSA-168898 4.558253e-02 1.341 0 0
Meiotic recombination R-HSA-912446 4.669032e-02 1.331 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.832451e-02 1.316 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.832451e-02 1.316 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.832451e-02 1.316 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.832451e-02 1.316 1 1
Diseases of Base Excision Repair R-HSA-9605308 4.832451e-02 1.316 0 0
DNA Double Strand Break Response R-HSA-5693606 4.856705e-02 1.314 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.902018e-02 1.310 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.986533e-02 1.302 0 0
G2/M Checkpoints R-HSA-69481 5.020589e-02 1.299 0 0
Regulated Necrosis R-HSA-5218859 5.141698e-02 1.289 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.147286e-02 1.288 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.147286e-02 1.288 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.147286e-02 1.288 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.147286e-02 1.288 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.147286e-02 1.288 0 0
Chromatin organization R-HSA-4839726 5.158139e-02 1.288 0 0
Stabilization of p53 R-HSA-69541 5.287736e-02 1.277 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.310697e-02 1.275 0 0
Meiotic synapsis R-HSA-1221632 5.316974e-02 1.274 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.390286e-02 1.268 1 0
Apoptosis R-HSA-109581 5.567684e-02 1.254 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.660413e-02 1.247 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.139163e-02 1.146 0 0
PTK6 Expression R-HSA-8849473 7.139163e-02 1.146 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.139163e-02 1.146 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.798724e-02 1.237 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.871606e-02 1.163 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.531140e-02 1.185 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.798724e-02 1.237 0 0
Chromatin modifying enzymes R-HSA-3247509 5.716583e-02 1.243 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.798724e-02 1.237 0 0
MTOR signalling R-HSA-165159 7.001989e-02 1.155 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.110664e-02 1.214 0 0
Signaling by NOTCH4 R-HSA-9013694 7.070130e-02 1.151 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.742712e-02 1.241 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.001989e-02 1.155 0 0
Reproduction R-HSA-1474165 5.871420e-02 1.231 0 0
Depyrimidination R-HSA-73928 7.001989e-02 1.155 0 0
Neurofascin interactions R-HSA-447043 5.946737e-02 1.226 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.819652e-02 1.235 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.445647e-02 1.191 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.990168e-02 1.156 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.386420e-02 1.195 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.158512e-02 1.145 0 0
Mitotic Prophase R-HSA-68875 7.261811e-02 1.139 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.412333e-02 1.130 0 0
Activation of BH3-only proteins R-HSA-114452 7.443746e-02 1.128 0 0
Signaling by SCF-KIT R-HSA-1433557 7.473089e-02 1.126 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.483800e-02 1.126 0 0
Hemostasis R-HSA-109582 7.624544e-02 1.118 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.716534e-02 1.113 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 7.994902e-02 1.097 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.039172e-02 1.095 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.066170e-02 1.093 0 0
Stimuli-sensing channels R-HSA-2672351 8.347520e-02 1.078 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 8.350085e-02 1.078 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 8.350085e-02 1.078 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 8.350085e-02 1.078 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 8.350085e-02 1.078 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 8.350085e-02 1.078 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 8.350085e-02 1.078 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 8.350085e-02 1.078 0 0
PTEN Regulation R-HSA-6807070 8.397007e-02 1.076 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 8.401056e-02 1.076 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 8.401056e-02 1.076 0 0
SLC-mediated bile acid transport R-HSA-9958517 8.401056e-02 1.076 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 8.401056e-02 1.076 0 0
Cellular response to chemical stress R-HSA-9711123 8.485512e-02 1.071 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.657436e-02 1.063 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.657436e-02 1.063 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.886826e-02 1.051 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.886826e-02 1.051 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.886826e-02 1.051 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.971881e-02 1.047 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.986417e-02 1.046 0 0
Apoptotic execution phase R-HSA-75153 8.986417e-02 1.046 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.029638e-02 1.044 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.029638e-02 1.044 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.029638e-02 1.044 0 0
Signaling by VEGF R-HSA-194138 9.029638e-02 1.044 0 0
Interferon gamma signaling R-HSA-877300 9.136386e-02 1.039 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.226026e-01 0.912 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.226026e-01 0.912 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.226026e-01 0.912 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.226026e-01 0.912 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 1.226026e-01 0.912 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 1.226026e-01 0.912 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 1.226026e-01 0.912 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.226026e-01 0.912 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 1.226026e-01 0.912 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.226026e-01 0.912 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.226026e-01 0.912 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 1.226026e-01 0.912 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.226026e-01 0.912 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.226026e-01 0.912 0 0
ARMS-mediated activation R-HSA-170984 9.724338e-02 1.012 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 9.724338e-02 1.012 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.110149e-01 0.955 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.062669e-01 0.974 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.064410e-01 0.973 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.207262e-01 0.918 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.336738e-02 1.030 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.336738e-02 1.030 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.079183e-01 0.967 0 0
Processing of DNA double-strand break ends R-HSA-5693607 9.796387e-02 1.009 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.298044e-02 1.032 0 0
Integrin signaling R-HSA-354192 9.298044e-02 1.032 0 0
Regulation of CDH11 function R-HSA-9762292 1.110149e-01 0.955 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 9.740866e-02 1.011 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.042071e-01 0.982 0 0
mRNA Editing R-HSA-75072 9.724338e-02 1.012 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.111923e-01 0.954 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.111923e-01 0.954 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.064550e-01 0.973 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.064550e-01 0.973 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.182292e-01 0.927 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.960458e-02 1.002 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.130138e-01 0.947 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.134837e-01 0.945 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.226026e-01 0.912 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 1.110149e-01 0.955 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.110149e-01 0.955 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.110149e-01 0.955 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.154264e-01 0.938 0 0
Lipophagy R-HSA-9613354 9.724338e-02 1.012 0 0
RUNX2 regulates bone development R-HSA-8941326 1.207262e-01 0.918 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 1.064410e-01 0.973 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.121679e-01 0.950 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.375772e-02 1.028 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.248706e-01 0.904 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.252553e-01 0.902 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.252553e-01 0.902 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.252553e-01 0.902 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.252553e-01 0.902 0 0
Signaling by APC mutants R-HSA-4839744 1.252553e-01 0.902 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.252553e-01 0.902 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.252553e-01 0.902 0 0
Homology Directed Repair R-HSA-5693538 1.275979e-01 0.894 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 1.281617e-01 0.892 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.317477e-01 0.880 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.317477e-01 0.880 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.340213e-01 0.873 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.345826e-01 0.871 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.600384e-01 0.796 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 1.600384e-01 0.796 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 1.600384e-01 0.796 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 1.958791e-01 0.708 0 0
Defective ABCC2 causes DJS R-HSA-5679001 1.958791e-01 0.708 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.958791e-01 0.708 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.958791e-01 0.708 0 0
MET activates PTPN11 R-HSA-8865999 1.958791e-01 0.708 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.398996e-01 0.854 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.398996e-01 0.854 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.398996e-01 0.854 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.548876e-01 0.810 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.701633e-01 0.769 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.013753e-01 0.696 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.757676e-01 0.755 0 0
DNA methylation R-HSA-5334118 1.975267e-01 0.704 0 0
Late endosomal microautophagy R-HSA-9615710 1.975267e-01 0.704 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.460332e-01 0.836 0 0
Centrosome maturation R-HSA-380287 1.579186e-01 0.802 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.357833e-01 0.867 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.596918e-01 0.797 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.398996e-01 0.854 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.504018e-01 0.823 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.975267e-01 0.704 0 0
Telomere Extension By Telomerase R-HSA-171319 1.865638e-01 0.729 0 0
Adipogenesis R-HSA-9843745 1.968066e-01 0.706 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.386354e-01 0.858 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.386354e-01 0.858 0 0
RMTs methylate histone arginines R-HSA-3214858 1.937203e-01 0.713 0 0
TNF signaling R-HSA-75893 1.504018e-01 0.823 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 1.530502e-01 0.815 0 0
Leishmania phagocytosis R-HSA-9664417 1.530502e-01 0.815 0 0
Parasite infection R-HSA-9664407 1.530502e-01 0.815 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.701633e-01 0.769 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.773038e-01 0.751 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.997904e-01 0.699 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.515558e-01 0.819 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.515558e-01 0.819 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.857252e-01 0.731 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.600384e-01 0.796 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.958791e-01 0.708 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.398996e-01 0.854 0 0
Signaling by AXIN mutants R-HSA-4839735 1.398996e-01 0.854 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 1.701633e-01 0.769 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.757676e-01 0.755 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.515558e-01 0.819 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.006322e-01 0.698 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.006322e-01 0.698 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.446151e-01 0.840 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.445453e-01 0.840 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.446151e-01 0.840 0 0
TRP channels R-HSA-3295583 1.651547e-01 0.782 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.975267e-01 0.704 0 0
TGFBR3 expression R-HSA-9839394 1.547416e-01 0.810 0 0
Pyroptosis R-HSA-5620971 1.865638e-01 0.729 0 0
Depurination R-HSA-73927 1.357833e-01 0.867 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.495918e-01 0.825 0 0
Intracellular oxygen transport R-HSA-8981607 1.958791e-01 0.708 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.893595e-01 0.723 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.435838e-01 0.843 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.013753e-01 0.696 0 0
Platelet degranulation R-HSA-114608 1.721525e-01 0.764 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.019095e-01 0.695 0 0
Base Excision Repair R-HSA-73884 1.454796e-01 0.837 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.019095e-01 0.695 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.019095e-01 0.695 0 0
Interleukin-6 family signaling R-HSA-6783589 1.445453e-01 0.840 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.889067e-01 0.724 0 0
Activation of RAC1 R-HSA-428540 1.398996e-01 0.854 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.701633e-01 0.769 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 1.701633e-01 0.769 0 0
Regulation of KIT signaling R-HSA-1433559 1.856752e-01 0.731 0 0
Axon guidance R-HSA-422475 1.608189e-01 0.794 1 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.596918e-01 0.797 0 0
EPH-Ephrin signaling R-HSA-2682334 1.615504e-01 0.792 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.937203e-01 0.713 0 0
Neurodegenerative Diseases R-HSA-8863678 1.445453e-01 0.840 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.445453e-01 0.840 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.835618e-01 0.736 0 0
Formation of the nephric duct R-HSA-9830364 1.547416e-01 0.810 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.398996e-01 0.854 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.013753e-01 0.696 0 0
G alpha (12/13) signalling events R-HSA-416482 1.765011e-01 0.753 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.013753e-01 0.696 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.000301e-01 0.699 0 0
Interleukin-7 signaling R-HSA-1266695 1.547416e-01 0.810 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.931277e-01 0.714 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.548876e-01 0.810 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.701633e-01 0.769 0 0
Signal regulatory protein family interactions R-HSA-391160 1.856752e-01 0.731 0 0
Regulation of beta-cell development R-HSA-186712 1.712443e-01 0.766 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.025591e-01 0.693 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.053259e-01 0.688 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.070672e-01 0.684 0 0
FOXO-mediated transcription R-HSA-9614085 2.079719e-01 0.682 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.086403e-01 0.681 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 2.086403e-01 0.681 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.086403e-01 0.681 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.301926e-01 0.638 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.301926e-01 0.638 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.301926e-01 0.638 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 2.301926e-01 0.638 0 0
Signaling by LRP5 mutants R-HSA-5339717 2.301926e-01 0.638 0 0
NrCAM interactions R-HSA-447038 2.630438e-01 0.580 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.630438e-01 0.580 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.944951e-01 0.531 0 0
Signaling by RNF43 mutants R-HSA-5340588 2.944951e-01 0.531 0 0
STAT5 Activation R-HSA-9645135 3.246059e-01 0.489 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.172195e-01 0.663 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.534334e-01 0.452 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.534334e-01 0.452 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.534334e-01 0.452 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.534334e-01 0.452 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.534334e-01 0.452 0 0
Recycling of eIF2:GDP R-HSA-72731 3.534334e-01 0.452 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.491799e-01 0.603 0 0
Type I hemidesmosome assembly R-HSA-446107 3.810321e-01 0.419 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.810321e-01 0.419 0 0
phospho-PLA2 pathway R-HSA-111995 3.810321e-01 0.419 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.812676e-01 0.551 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.074543e-01 0.390 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.074543e-01 0.390 0 0
CASP8 activity is inhibited R-HSA-5218900 4.074543e-01 0.390 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.972814e-01 0.527 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.972814e-01 0.527 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.972814e-01 0.527 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.972814e-01 0.527 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.132388e-01 0.504 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.291155e-01 0.483 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.291155e-01 0.483 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.297436e-01 0.639 0 0
FGFR2 alternative splicing R-HSA-6803529 3.448894e-01 0.462 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.448894e-01 0.462 0 0
RET signaling R-HSA-8853659 2.893705e-01 0.539 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.893705e-01 0.539 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.914025e-01 0.407 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.065824e-01 0.391 0 0
Packaging Of Telomere Ends R-HSA-171306 4.215768e-01 0.375 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.447793e-01 0.462 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.184098e-01 0.378 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.404294e-01 0.468 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.710393e-01 0.431 0 0
Formation of definitive endoderm R-HSA-9823730 2.972814e-01 0.527 0 0
Cellular response to hypoxia R-HSA-1234174 3.936496e-01 0.405 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.065824e-01 0.391 0 0
Chromosome Maintenance R-HSA-73886 2.397420e-01 0.620 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.252197e-01 0.488 0 0
Telomere Maintenance R-HSA-157579 3.328140e-01 0.478 0 0
Extension of Telomeres R-HSA-180786 3.349979e-01 0.475 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.215768e-01 0.375 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.011519e-01 0.521 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.452931e-01 0.610 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.944951e-01 0.531 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.331669e-01 0.632 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.074543e-01 0.390 0 0
mTORC1-mediated signalling R-HSA-166208 3.448894e-01 0.462 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.365854e-01 0.473 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.483882e-01 0.458 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.630438e-01 0.580 0 0
Calcineurin activates NFAT R-HSA-2025928 4.074543e-01 0.390 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.914025e-01 0.407 0 0
HCMV Early Events R-HSA-9609690 2.334346e-01 0.632 0 0
Mitophagy R-HSA-5205647 2.659262e-01 0.575 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.261434e-01 0.646 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.331669e-01 0.632 0 0
Prolonged ERK activation events R-HSA-169893 2.172195e-01 0.663 1 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.556140e-01 0.592 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.301926e-01 0.638 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 2.301926e-01 0.638 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.301926e-01 0.638 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.944951e-01 0.531 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.810321e-01 0.419 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.074543e-01 0.390 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.011519e-01 0.521 0 0
HATs acetylate histones R-HSA-3214847 3.480628e-01 0.458 0 0
Proteasome assembly R-HSA-9907900 3.952818e-01 0.403 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.011519e-01 0.521 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.427282e-01 0.615 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.652241e-01 0.576 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.291155e-01 0.483 0 0
GABA synthesis R-HSA-888568 2.301926e-01 0.638 0 0
Reelin signalling pathway R-HSA-8866376 2.630438e-01 0.580 0 0
Suppression of autophagy R-HSA-9636569 2.630438e-01 0.580 0 0
Phosphorylation of Emi1 R-HSA-176417 2.944951e-01 0.531 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.944951e-01 0.531 0 0
PKB-mediated events R-HSA-109703 2.944951e-01 0.531 0 0
PDE3B signalling R-HSA-165160 2.944951e-01 0.531 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.944951e-01 0.531 0 0
NADPH regeneration R-HSA-389542 3.246059e-01 0.489 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.534334e-01 0.452 0 0
Regulation by c-FLIP R-HSA-3371378 3.810321e-01 0.419 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.652241e-01 0.576 0 0
Unwinding of DNA R-HSA-176974 4.074543e-01 0.390 0 0
Signaling by NODAL R-HSA-1181150 2.972814e-01 0.527 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.291155e-01 0.483 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.672531e-01 0.573 0 0
Metalloprotease DUBs R-HSA-5689901 4.065824e-01 0.391 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.101076e-01 0.508 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.328140e-01 0.478 0 0
Hedgehog 'on' state R-HSA-5632684 2.637603e-01 0.579 0 0
Somitogenesis R-HSA-9824272 4.068794e-01 0.391 0 0
DNA Repair R-HSA-73894 3.937500e-01 0.405 0 0
Polo-like kinase mediated events R-HSA-156711 2.652241e-01 0.576 0 0
Interleukin-9 signaling R-HSA-8985947 3.810321e-01 0.419 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.184952e-01 0.497 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.194940e-01 0.659 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.534334e-01 0.452 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.252197e-01 0.488 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.810321e-01 0.419 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.972814e-01 0.527 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.055771e-01 0.392 1 0
HCMV Infection R-HSA-9609646 3.975790e-01 0.401 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.301926e-01 0.638 0 0
Muscarinic acetylcholine receptors R-HSA-390648 2.630438e-01 0.580 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.534334e-01 0.452 0 0
Interleukin-21 signaling R-HSA-9020958 4.074543e-01 0.390 0 0
Circadian clock R-HSA-9909396 3.198608e-01 0.495 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.190853e-01 0.496 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.306300e-01 0.481 0 0
Ephrin signaling R-HSA-3928664 2.652241e-01 0.576 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.427282e-01 0.615 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.448894e-01 0.462 0 0
Signaling by EGFR R-HSA-177929 3.057539e-01 0.515 0 0
Deubiquitination R-HSA-5688426 2.253592e-01 0.647 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.205787e-01 0.656 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.914025e-01 0.407 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.914025e-01 0.407 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.282155e-01 0.642 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.301926e-01 0.638 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.944951e-01 0.531 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.246059e-01 0.489 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.534334e-01 0.452 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.534334e-01 0.452 0 0
Dimerization of procaspase-8 R-HSA-69416 3.810321e-01 0.419 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.810321e-01 0.419 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.074543e-01 0.390 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.074543e-01 0.390 1 1
Cleavage of the damaged purine R-HSA-110331 3.011519e-01 0.521 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.561773e-01 0.448 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.719237e-01 0.566 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.545664e-01 0.450 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.198886e-01 0.658 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.768041e-01 0.558 0 0
Interleukin-1 signaling R-HSA-9020702 3.633709e-01 0.440 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.776243e-01 0.557 0 0
Glycolysis R-HSA-70171 2.141020e-01 0.669 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.068794e-01 0.391 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.491799e-01 0.603 1 1
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.246059e-01 0.489 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.246059e-01 0.489 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.804869e-01 0.552 0 0
Developmental Biology R-HSA-1266738 4.166252e-01 0.380 1 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.172195e-01 0.663 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.968809e-01 0.527 0 0
Interleukin-20 family signaling R-HSA-8854691 3.605404e-01 0.443 0 0
Muscle contraction R-HSA-397014 2.180279e-01 0.661 0 0
Transmission across Chemical Synapses R-HSA-112315 3.302690e-01 0.481 0 0
Adaptive Immune System R-HSA-1280218 2.218611e-01 0.654 0 0
Post-translational protein modification R-HSA-597592 2.549389e-01 0.594 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.785982e-01 0.555 0 0
Dopamine receptors R-HSA-390651 2.301926e-01 0.638 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.301926e-01 0.638 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.944951e-01 0.531 0 0
Relaxin receptors R-HSA-444821 2.944951e-01 0.531 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.246059e-01 0.489 0 0
Negative regulation of FLT3 R-HSA-9706369 2.172195e-01 0.663 0 0
Netrin mediated repulsion signals R-HSA-418886 3.534334e-01 0.452 0 0
RSK activation R-HSA-444257 3.810321e-01 0.419 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.074543e-01 0.390 0 0
Glucose metabolism R-HSA-70326 3.471755e-01 0.459 0 0
Semaphorin interactions R-HSA-373755 3.741330e-01 0.427 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.132388e-01 0.504 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.914025e-01 0.407 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.155046e-01 0.501 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.056794e-01 0.515 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.074543e-01 0.390 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 4.074543e-01 0.390 0 0
RSV-host interactions R-HSA-9833110 3.940658e-01 0.404 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.263225e-01 0.486 0 0
Nervous system development R-HSA-9675108 2.556251e-01 0.592 1 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.074543e-01 0.390 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.944951e-01 0.531 0 0
Nef and signal transduction R-HSA-164944 3.246059e-01 0.489 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.074543e-01 0.390 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.074543e-01 0.390 0 0
Platelet homeostasis R-HSA-418346 2.587073e-01 0.587 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.670004e-01 0.573 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.914025e-01 0.407 0 0
Interleukin-2 family signaling R-HSA-451927 3.365854e-01 0.473 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.719178e-01 0.430 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.427282e-01 0.615 0 0
Ion channel transport R-HSA-983712 3.013324e-01 0.521 0 0
Gluconeogenesis R-HSA-70263 2.297436e-01 0.639 0 0
Signaling by TGFBR3 R-HSA-9839373 2.115146e-01 0.675 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.228140e-01 0.652 1 0
Cellular response to mitochondrial stress R-HSA-9840373 4.074543e-01 0.390 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.074543e-01 0.390 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.605404e-01 0.443 0 0
Mitochondrial biogenesis R-HSA-1592230 2.165758e-01 0.664 0 0
NGF-stimulated transcription R-HSA-9031628 2.297436e-01 0.639 0 0
Signaling by KIT in disease R-HSA-9669938 3.448894e-01 0.462 0 0
Signaling by NTRKs R-HSA-166520 3.017109e-01 0.520 1 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.719650e-01 0.565 0 0
Growth hormone receptor signaling R-HSA-982772 3.605404e-01 0.443 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.215768e-01 0.375 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.297436e-01 0.639 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.215768e-01 0.375 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.476480e-01 0.459 0 0
Heme signaling R-HSA-9707616 3.643530e-01 0.438 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.074543e-01 0.390 0 0
Apoptotic factor-mediated response R-HSA-111471 2.652241e-01 0.576 0 0
Ribavirin ADME R-HSA-9755088 3.291155e-01 0.483 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.410599e-01 0.467 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.312563e-01 0.636 0 0
Signaling by ALK R-HSA-201556 3.247710e-01 0.488 0 0
G-protein beta:gamma signalling R-HSA-397795 2.427282e-01 0.615 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.369408e-01 0.625 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.445814e-01 0.612 0 0
IRE1alpha activates chaperones R-HSA-381070 2.802818e-01 0.552 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.643530e-01 0.438 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.298653e-01 0.367 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.313922e-01 0.365 1 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.323556e-01 0.364 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.327502e-01 0.364 0 0
2-LTR circle formation R-HSA-164843 4.327502e-01 0.364 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.327502e-01 0.364 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.327502e-01 0.364 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.327502e-01 0.364 0 0
Interleukin-27 signaling R-HSA-9020956 4.327502e-01 0.364 0 0
Maturation of spike protein R-HSA-9683686 4.327502e-01 0.364 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.327502e-01 0.364 0 0
Sperm Motility And Taxes R-HSA-1300642 4.327502e-01 0.364 0 0
Signaling by Leptin R-HSA-2586552 4.327502e-01 0.364 0 0
MAPK family signaling cascades R-HSA-5683057 4.339459e-01 0.363 1 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.363738e-01 0.360 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.363738e-01 0.360 0 0
COPII-mediated vesicle transport R-HSA-204005 4.419340e-01 0.355 0 0
ESR-mediated signaling R-HSA-8939211 4.452350e-01 0.351 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.509629e-01 0.346 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.509629e-01 0.346 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.509629e-01 0.346 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.509629e-01 0.346 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.514638e-01 0.345 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.514638e-01 0.345 0 0
Degradation of CDH1 R-HSA-9766229 4.525233e-01 0.344 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.569677e-01 0.340 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.569677e-01 0.340 0 0
Bicarbonate transporters R-HSA-425381 4.569677e-01 0.340 0 0
Interleukin-2 signaling R-HSA-9020558 4.569677e-01 0.340 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.580070e-01 0.339 0 0
Ub-specific processing proteases R-HSA-5689880 4.592789e-01 0.338 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.609405e-01 0.336 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.609405e-01 0.336 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.609405e-01 0.336 0 0
PI3K Cascade R-HSA-109704 4.637127e-01 0.334 0 0
Neurotransmitter clearance R-HSA-112311 4.653351e-01 0.332 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.653351e-01 0.332 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.663377e-01 0.331 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.748009e-01 0.323 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 4.776867e-01 0.321 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.790517e-01 0.320 1 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.794821e-01 0.319 0 0
Budding and maturation of HIV virion R-HSA-162588 4.794821e-01 0.319 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.794821e-01 0.319 0 0
Downstream signal transduction R-HSA-186763 4.794821e-01 0.319 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.801527e-01 0.319 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 4.801527e-01 0.319 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.801527e-01 0.319 0 0
ERKs are inactivated R-HSA-202670 4.801527e-01 0.319 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.801527e-01 0.319 0 0
Integration of provirus R-HSA-162592 4.801527e-01 0.319 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.857825e-01 0.314 0 0
Neurexins and neuroligins R-HSA-6794361 4.857825e-01 0.314 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 4.890113e-01 0.311 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.890113e-01 0.311 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.933971e-01 0.307 0 0
DNA strand elongation R-HSA-69190 4.933971e-01 0.307 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.966522e-01 0.304 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.966522e-01 0.304 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.982356e-01 0.303 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.023491e-01 0.299 0 0
Leading Strand Synthesis R-HSA-69109 5.023491e-01 0.299 0 0
Polymerase switching R-HSA-69091 5.023491e-01 0.299 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.023491e-01 0.299 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.023491e-01 0.299 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.023491e-01 0.299 0 0
Interleukin-35 Signalling R-HSA-8984722 5.023491e-01 0.299 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.023491e-01 0.299 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 5.023491e-01 0.299 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.023491e-01 0.299 0 0
Repression of WNT target genes R-HSA-4641265 5.023491e-01 0.299 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.023491e-01 0.299 0 0
OAS antiviral response R-HSA-8983711 5.023491e-01 0.299 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.070740e-01 0.295 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.070740e-01 0.295 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.070740e-01 0.295 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.070740e-01 0.295 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.070740e-01 0.295 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.070740e-01 0.295 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.070740e-01 0.295 0 0
Cardiogenesis R-HSA-9733709 5.070740e-01 0.295 0 0
Translation initiation complex formation R-HSA-72649 5.074054e-01 0.295 0 0
Signaling by TGFB family members R-HSA-9006936 5.136438e-01 0.289 0 0
RNA Polymerase I Transcription R-HSA-73864 5.164644e-01 0.287 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.205079e-01 0.284 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.205079e-01 0.284 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.205079e-01 0.284 0 0
Glutamate and glutamine metabolism R-HSA-8964539 5.205079e-01 0.284 0 0
Signaling by WNT R-HSA-195721 5.218860e-01 0.282 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.235991e-01 0.281 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.235991e-01 0.281 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.235991e-01 0.281 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.235991e-01 0.281 0 0
Frs2-mediated activation R-HSA-170968 5.235991e-01 0.281 1 1
Formation of axial mesoderm R-HSA-9796292 5.235991e-01 0.281 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.235991e-01 0.281 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.235991e-01 0.281 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.285446e-01 0.277 0 0
Signaling by NOTCH2 R-HSA-1980145 5.336946e-01 0.273 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.336946e-01 0.273 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.336946e-01 0.273 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.336946e-01 0.273 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 5.336946e-01 0.273 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.336946e-01 0.273 0 0
Signal amplification R-HSA-392518 5.336946e-01 0.273 0 0
Signaling by FGFR2 R-HSA-5654738 5.343791e-01 0.272 0 0
SARS-CoV Infections R-HSA-9679506 5.369631e-01 0.270 0 0
IRS-mediated signalling R-HSA-112399 5.389229e-01 0.268 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.430405e-01 0.265 0 0
Amyloid fiber formation R-HSA-977225 5.432114e-01 0.265 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.439430e-01 0.264 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.439430e-01 0.264 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.439430e-01 0.264 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 5.439430e-01 0.264 0 0
Hydrolysis of LPC R-HSA-1483115 5.439430e-01 0.264 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.439430e-01 0.264 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.439430e-01 0.264 0 0
Prolactin receptor signaling R-HSA-1170546 5.439430e-01 0.264 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.439430e-01 0.264 0 0
Acyl chain remodeling of CL R-HSA-1482798 5.439430e-01 0.264 0 0
Zinc transporters R-HSA-435354 5.439430e-01 0.264 0 0
Regulation of Apoptosis R-HSA-169911 5.466307e-01 0.262 0 0
Signalling to ERKs R-HSA-187687 5.466307e-01 0.262 1 0
PI Metabolism R-HSA-1483255 5.470371e-01 0.262 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.491692e-01 0.260 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.505521e-01 0.259 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.538314e-01 0.257 0 0
Formation of the cornified envelope R-HSA-6809371 5.575911e-01 0.254 0 0
Neuronal System R-HSA-112316 5.580781e-01 0.253 0 0
FLT3 signaling in disease R-HSA-9682385 5.593135e-01 0.252 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 5.606133e-01 0.251 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.634192e-01 0.249 0 0
Translesion synthesis by REV1 R-HSA-110312 5.634192e-01 0.249 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.634192e-01 0.249 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.634192e-01 0.249 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.634192e-01 0.249 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.634192e-01 0.249 0 0
Signaling by Activin R-HSA-1502540 5.634192e-01 0.249 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.634192e-01 0.249 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.634192e-01 0.249 0 0
Protein methylation R-HSA-8876725 5.634192e-01 0.249 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 5.634192e-01 0.249 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.634192e-01 0.249 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.634192e-01 0.249 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.634192e-01 0.249 0 0
Signaling by ERBB2 R-HSA-1227986 5.692533e-01 0.245 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.712043e-01 0.243 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.717411e-01 0.243 0 0
Metabolism of folate and pterines R-HSA-196757 5.717411e-01 0.243 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.776494e-01 0.238 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.790859e-01 0.237 0 0
MAP kinase activation R-HSA-450294 5.790859e-01 0.237 0 0
Translesion synthesis by POLI R-HSA-5656121 5.820649e-01 0.235 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 5.820649e-01 0.235 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 5.820649e-01 0.235 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.820649e-01 0.235 0 0
Phosphorylation of the APC/C R-HSA-176412 5.820649e-01 0.235 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.820649e-01 0.235 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.820649e-01 0.235 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 5.820649e-01 0.235 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.820649e-01 0.235 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 5.820649e-01 0.235 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.820649e-01 0.235 0 0
Differentiation of T cells R-HSA-9945266 5.820649e-01 0.235 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.820649e-01 0.235 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.820649e-01 0.235 0 0
Killing mechanisms R-HSA-9664420 5.820649e-01 0.235 0 0
Activation of SMO R-HSA-5635838 5.820649e-01 0.235 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.820649e-01 0.235 0 0
Atorvastatin ADME R-HSA-9754706 5.820649e-01 0.235 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.824268e-01 0.235 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.839122e-01 0.234 0 0
S Phase R-HSA-69242 5.858450e-01 0.232 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.887760e-01 0.230 0 0
Gastrulation R-HSA-9758941 5.921113e-01 0.228 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.958260e-01 0.225 0 0
Pentose phosphate pathway R-HSA-71336 5.958260e-01 0.225 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.998858e-01 0.222 0 0
Translesion synthesis by POLK R-HSA-5655862 5.999153e-01 0.222 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.999153e-01 0.222 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.999153e-01 0.222 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.999153e-01 0.222 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 5.999153e-01 0.222 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.999153e-01 0.222 0 0
Passive transport by Aquaporins R-HSA-432047 5.999153e-01 0.222 0 0
Fibronectin matrix formation R-HSA-1566977 5.999153e-01 0.222 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.999153e-01 0.222 0 0
Galactose catabolism R-HSA-70370 5.999153e-01 0.222 0 0
tRNA modification in the mitochondrion R-HSA-6787450 5.999153e-01 0.222 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.053421e-01 0.218 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.071471e-01 0.217 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.074822e-01 0.216 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.074822e-01 0.216 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.074822e-01 0.216 0 0
Diseases of Immune System R-HSA-5260271 6.074822e-01 0.216 0 0
Glycogen metabolism R-HSA-8982491 6.074822e-01 0.216 0 0
IGF1R signaling cascade R-HSA-2428924 6.077210e-01 0.216 0 0
Insulin receptor signalling cascade R-HSA-74751 6.077210e-01 0.216 0 0
TCR signaling R-HSA-202403 6.143322e-01 0.212 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.169729e-01 0.210 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.170044e-01 0.210 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.170044e-01 0.210 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.170044e-01 0.210 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.170044e-01 0.210 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 6.170044e-01 0.210 0 0
Downstream TCR signaling R-HSA-202424 6.264137e-01 0.203 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.300236e-01 0.201 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.300236e-01 0.201 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.300236e-01 0.201 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.300236e-01 0.201 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 6.300236e-01 0.201 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.300236e-01 0.201 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.333645e-01 0.198 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.333645e-01 0.198 0 0
GAB1 signalosome R-HSA-180292 6.333645e-01 0.198 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.333645e-01 0.198 0 0
Tie2 Signaling R-HSA-210993 6.333645e-01 0.198 0 0
Kidney development R-HSA-9830369 6.350295e-01 0.197 0 0
Viral Infection Pathways R-HSA-9824446 6.388014e-01 0.195 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.409105e-01 0.193 0 0
Ca-dependent events R-HSA-111996 6.409105e-01 0.193 0 0
mRNA Splicing R-HSA-72172 6.415817e-01 0.193 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.438325e-01 0.191 0 0
Translesion Synthesis by POLH R-HSA-110320 6.490267e-01 0.188 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.490267e-01 0.188 0 0
Pyrimidine biosynthesis R-HSA-500753 6.490267e-01 0.188 0 0
Regulation of signaling by CBL R-HSA-912631 6.490267e-01 0.188 0 0
Specification of the neural plate border R-HSA-9834899 6.490267e-01 0.188 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.490267e-01 0.188 0 0
Rap1 signalling R-HSA-392517 6.490267e-01 0.188 0 0
Signaling by FGFR4 R-HSA-5654743 6.515435e-01 0.186 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.515435e-01 0.186 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.609853e-01 0.180 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.609853e-01 0.180 0 0
Interleukin-17 signaling R-HSA-448424 6.609853e-01 0.180 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.609853e-01 0.180 0 0
G1 Phase R-HSA-69236 6.619244e-01 0.179 0 0
Cyclin D associated events in G1 R-HSA-69231 6.619244e-01 0.179 0 0
Amine ligand-binding receptors R-HSA-375280 6.619244e-01 0.179 0 0
Netrin-1 signaling R-HSA-373752 6.619244e-01 0.179 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.623581e-01 0.179 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.640208e-01 0.178 0 0
Nephrin family interactions R-HSA-373753 6.640208e-01 0.178 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.640208e-01 0.178 0 0
Negative regulation of MET activity R-HSA-6807004 6.640208e-01 0.178 0 0
Creatine metabolism R-HSA-71288 6.640208e-01 0.178 0 0
Acyl chain remodelling of PI R-HSA-1482922 6.640208e-01 0.178 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.640208e-01 0.178 0 0
Protein hydroxylation R-HSA-9629569 6.640208e-01 0.178 0 0
Glycogen synthesis R-HSA-3322077 6.640208e-01 0.178 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.693346e-01 0.174 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.693346e-01 0.174 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.693346e-01 0.174 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.720553e-01 0.173 0 0
Nucleosome assembly R-HSA-774815 6.720553e-01 0.173 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.720553e-01 0.173 0 0
Signaling by FGFR3 R-HSA-5654741 6.720553e-01 0.173 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.720553e-01 0.173 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.720553e-01 0.173 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.720553e-01 0.173 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 6.775325e-01 0.169 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.783751e-01 0.169 0 0
Lagging Strand Synthesis R-HSA-69186 6.783751e-01 0.169 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.783751e-01 0.169 0 0
ERK/MAPK targets R-HSA-198753 6.783751e-01 0.169 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 6.783751e-01 0.169 0 0
Acyl chain remodelling of PG R-HSA-1482925 6.783751e-01 0.169 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.783751e-01 0.169 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.783751e-01 0.169 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.817796e-01 0.166 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.915768e-01 0.160 0 0
Synthesis of PC R-HSA-1483191 6.915768e-01 0.160 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.921171e-01 0.160 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.921171e-01 0.160 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.921171e-01 0.160 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.921171e-01 0.160 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.921171e-01 0.160 0 0
Assembly Of The HIV Virion R-HSA-175474 6.921171e-01 0.160 0 0
Glutathione synthesis and recycling R-HSA-174403 6.921171e-01 0.160 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.921171e-01 0.160 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.921171e-01 0.160 0 0
Signaling by FGFR R-HSA-190236 6.993090e-01 0.155 0 0
Cellular response to heat stress R-HSA-3371556 7.003917e-01 0.155 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 7.012200e-01 0.154 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.052726e-01 0.152 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.052726e-01 0.152 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.052726e-01 0.152 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.052726e-01 0.152 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.052726e-01 0.152 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.052726e-01 0.152 1 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.052726e-01 0.152 0 0
UCH proteinases R-HSA-5689603 7.088154e-01 0.149 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.101303e-01 0.149 0 0
Termination of O-glycan biosynthesis R-HSA-977068 7.178669e-01 0.144 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.178669e-01 0.144 0 0
Biosynthesis of maresins R-HSA-9018682 7.178669e-01 0.144 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.178669e-01 0.144 0 0
Formation of the ureteric bud R-HSA-9830674 7.178669e-01 0.144 0 0
Syndecan interactions R-HSA-3000170 7.178669e-01 0.144 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.178669e-01 0.144 0 0
Host Interactions of HIV factors R-HSA-162909 7.182374e-01 0.144 0 0
Azathioprine ADME R-HSA-9748787 7.190519e-01 0.143 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.193183e-01 0.143 0 0
Integrin cell surface interactions R-HSA-216083 7.235597e-01 0.141 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.277411e-01 0.138 0 0
HSF1-dependent transactivation R-HSA-3371571 7.277411e-01 0.138 0 0
CYP2E1 reactions R-HSA-211999 7.299237e-01 0.137 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.299237e-01 0.137 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.299237e-01 0.137 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.299237e-01 0.137 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.299237e-01 0.137 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.299237e-01 0.137 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.299237e-01 0.137 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.299237e-01 0.137 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.299237e-01 0.137 0 0
Sensory processing of sound R-HSA-9659379 7.307105e-01 0.136 0 0
Asparagine N-linked glycosylation R-HSA-446203 7.348810e-01 0.134 0 0
Orc1 removal from chromatin R-HSA-68949 7.362016e-01 0.133 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.362016e-01 0.133 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.362016e-01 0.133 1 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.377152e-01 0.132 0 0
Signaling by MET R-HSA-6806834 7.377152e-01 0.132 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.378504e-01 0.132 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.378504e-01 0.132 0 0
Long-term potentiation R-HSA-9620244 7.414659e-01 0.130 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.414659e-01 0.130 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.414659e-01 0.130 0 0
Tight junction interactions R-HSA-420029 7.414659e-01 0.130 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.414659e-01 0.130 0 0
Hyaluronan degradation R-HSA-2160916 7.414659e-01 0.130 0 0
Fertilization R-HSA-1187000 7.414659e-01 0.130 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.414659e-01 0.130 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.414659e-01 0.130 0 0
Laminin interactions R-HSA-3000157 7.414659e-01 0.130 0 0
Nucleotide biosynthesis R-HSA-8956320 7.444370e-01 0.128 0 0
HIV Infection R-HSA-162906 7.487640e-01 0.126 0 0
Disease R-HSA-1643685 7.511397e-01 0.124 1 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.511971e-01 0.124 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.524510e-01 0.124 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.525155e-01 0.123 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.525155e-01 0.123 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.525155e-01 0.123 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.525155e-01 0.123 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.525155e-01 0.123 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 7.525155e-01 0.123 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.525155e-01 0.123 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.525155e-01 0.123 0 0
DNA Replication R-HSA-69306 7.550187e-01 0.122 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.578641e-01 0.120 0 0
HDACs deacetylate histones R-HSA-3214815 7.602477e-01 0.119 0 0
Paracetamol ADME R-HSA-9753281 7.602477e-01 0.119 0 0
Leishmania infection R-HSA-9658195 7.610965e-01 0.119 0 0
Parasitic Infection Pathways R-HSA-9824443 7.610965e-01 0.119 0 0
Gene Silencing by RNA R-HSA-211000 7.613979e-01 0.118 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.630936e-01 0.117 0 0
Cristae formation R-HSA-8949613 7.630936e-01 0.117 0 0
Signaling by BMP R-HSA-201451 7.630936e-01 0.117 0 0
Triglyceride biosynthesis R-HSA-75109 7.630936e-01 0.117 0 0
Signaling by FGFR1 R-HSA-5654736 7.678308e-01 0.115 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.678308e-01 0.115 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.678308e-01 0.115 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.705898e-01 0.113 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.732201e-01 0.112 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.732201e-01 0.112 0 0
Dectin-2 family R-HSA-5621480 7.752044e-01 0.111 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.752044e-01 0.111 0 0
Synthesis of PA R-HSA-1483166 7.752044e-01 0.111 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.767450e-01 0.110 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.784153e-01 0.109 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.815745e-01 0.107 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.827639e-01 0.106 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.829143e-01 0.106 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.829143e-01 0.106 0 0
Platelet calcium homeostasis R-HSA-418360 7.829143e-01 0.106 0 0
DARPP-32 events R-HSA-180024 7.829143e-01 0.106 0 0
Metabolism of non-coding RNA R-HSA-194441 7.893393e-01 0.103 0 0
snRNP Assembly R-HSA-191859 7.893393e-01 0.103 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.921947e-01 0.101 0 0
Activation of the pre-replicative complex R-HSA-68962 7.921947e-01 0.101 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.921947e-01 0.101 0 0
DAP12 signaling R-HSA-2424491 7.921947e-01 0.101 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.921947e-01 0.101 0 0
Peptide chain elongation R-HSA-156902 7.943999e-01 0.100 0 0
Integration of energy metabolism R-HSA-163685 7.960471e-01 0.099 0 0
Glutathione conjugation R-HSA-156590 7.961088e-01 0.099 0 0
Metabolism of polyamines R-HSA-351202 7.961088e-01 0.099 0 0
ER-Phagosome pathway R-HSA-1236974 8.000203e-01 0.097 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.010790e-01 0.096 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.010790e-01 0.096 0 0
EGFR downregulation R-HSA-182971 8.010790e-01 0.096 0 0
Cargo concentration in the ER R-HSA-5694530 8.010790e-01 0.096 0 0
PLC beta mediated events R-HSA-112043 8.026851e-01 0.095 0 0
Aquaporin-mediated transport R-HSA-445717 8.026851e-01 0.095 0 0
Neurotransmitter release cycle R-HSA-112310 8.055115e-01 0.094 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.090724e-01 0.092 0 0
Mitochondrial protein import R-HSA-1268020 8.090724e-01 0.092 0 0
Signaling by PDGF R-HSA-186797 8.090724e-01 0.092 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.152748e-01 0.089 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 8.152748e-01 0.089 0 0
Signaling by PTK6 R-HSA-8848021 8.152748e-01 0.089 0 0
SLC transporter disorders R-HSA-5619102 8.162229e-01 0.088 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.177256e-01 0.087 0 0
Defective B3GALTL causes PpS R-HSA-5083635 8.177256e-01 0.087 0 0
Nuclear RNA decay R-HSA-9930044 8.177256e-01 0.087 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.177256e-01 0.087 0 0
Signaling by Insulin receptor R-HSA-74752 8.212284e-01 0.086 0 0
Ion transport by P-type ATPases R-HSA-936837 8.212965e-01 0.086 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.212965e-01 0.086 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.255198e-01 0.083 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.255198e-01 0.083 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.255198e-01 0.083 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.255198e-01 0.083 0 0
Heme degradation R-HSA-189483 8.255198e-01 0.083 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.262214e-01 0.083 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.313130e-01 0.080 0 0
Dual Incision in GG-NER R-HSA-5696400 8.329811e-01 0.079 0 0
Nuclear import of Rev protein R-HSA-180746 8.329811e-01 0.079 0 0
Hyaluronan metabolism R-HSA-2142845 8.329811e-01 0.079 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.329811e-01 0.079 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.329811e-01 0.079 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 8.329811e-01 0.079 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.358502e-01 0.078 0 0
G-protein mediated events R-HSA-112040 8.383179e-01 0.077 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.389343e-01 0.076 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.401237e-01 0.076 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.401237e-01 0.076 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.401237e-01 0.076 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.401237e-01 0.076 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.401237e-01 0.076 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.401237e-01 0.076 0 0
PERK regulates gene expression R-HSA-381042 8.401237e-01 0.076 0 0
RNA Polymerase III Transcription R-HSA-74158 8.469614e-01 0.072 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.469614e-01 0.072 0 0
Calmodulin induced events R-HSA-111933 8.469614e-01 0.072 0 0
CaM pathway R-HSA-111997 8.469614e-01 0.072 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.469614e-01 0.072 0 0
Glycosphingolipid transport R-HSA-9845576 8.469614e-01 0.072 0 0
HSF1 activation R-HSA-3371511 8.469614e-01 0.072 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.469614e-01 0.072 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.473108e-01 0.072 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.474656e-01 0.072 0 0
Signaling by ROBO receptors R-HSA-376176 8.500302e-01 0.071 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 8.535069e-01 0.069 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.535069e-01 0.069 0 0
Degradation of DVL R-HSA-4641258 8.535069e-01 0.069 0 0
Degradation of AXIN R-HSA-4641257 8.535069e-01 0.069 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.535069e-01 0.069 0 0
SLC-mediated transport of organic cations R-HSA-549127 8.535069e-01 0.069 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 8.538587e-01 0.069 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 8.587286e-01 0.066 0 0
G1/S Transition R-HSA-69206 8.589168e-01 0.066 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.597730e-01 0.066 0 0
MET promotes cell motility R-HSA-8875878 8.597730e-01 0.066 0 0
ABC-family proteins mediated transport R-HSA-382556 8.620224e-01 0.064 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.634496e-01 0.064 0 0
Purine catabolism R-HSA-74259 8.634496e-01 0.064 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.657713e-01 0.063 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.657713e-01 0.063 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.657713e-01 0.063 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.657713e-01 0.063 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.657713e-01 0.063 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.660096e-01 0.062 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.680257e-01 0.061 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.680257e-01 0.061 0 0
Aspirin ADME R-HSA-9749641 8.680257e-01 0.061 0 0
Developmental Cell Lineages R-HSA-9734767 8.680865e-01 0.061 0 0
Cell surface interactions at the vascular wall R-HSA-202733 8.715044e-01 0.060 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.715134e-01 0.060 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.715134e-01 0.060 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.715134e-01 0.060 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 8.715134e-01 0.060 0 0
Attenuation phase R-HSA-3371568 8.715134e-01 0.060 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.715134e-01 0.060 0 0
Generation of second messenger molecules R-HSA-202433 8.715134e-01 0.060 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.715134e-01 0.060 0 0
SLC-mediated transmembrane transport R-HSA-425407 8.716544e-01 0.060 0 0
PPARA activates gene expression R-HSA-1989781 8.723225e-01 0.059 0 0
Signaling by FGFR in disease R-HSA-1226099 8.724605e-01 0.059 0 0
Protein ubiquitination R-HSA-8852135 8.767579e-01 0.057 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.770103e-01 0.057 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.770103e-01 0.057 0 0
Maturation of spike protein R-HSA-9694548 8.770103e-01 0.057 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.770103e-01 0.057 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.770103e-01 0.057 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.770103e-01 0.057 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.770103e-01 0.057 0 0
Opioid Signalling R-HSA-111885 8.773685e-01 0.057 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.784228e-01 0.056 0 0
HIV Life Cycle R-HSA-162587 8.784228e-01 0.056 0 0
Cellular response to starvation R-HSA-9711097 8.813788e-01 0.055 0 0
HIV Transcription Initiation R-HSA-167161 8.822722e-01 0.054 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.822722e-01 0.054 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.822722e-01 0.054 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.822722e-01 0.054 0 0
Scavenging by Class A Receptors R-HSA-3000480 8.822722e-01 0.054 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.822722e-01 0.054 0 0
Translation of Structural Proteins R-HSA-9683701 8.822722e-01 0.054 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.849546e-01 0.053 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.873094e-01 0.052 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.873199e-01 0.052 0 0
PCP/CE pathway R-HSA-4086400 8.888611e-01 0.051 0 0
ABC transporter disorders R-HSA-5619084 8.888611e-01 0.051 0 0
Interleukin-10 signaling R-HSA-6783783 8.888611e-01 0.051 0 0
SLC-mediated transport of organic anions R-HSA-9955298 8.888611e-01 0.051 0 0
Synthesis of DNA R-HSA-69239 8.911810e-01 0.050 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.921313e-01 0.050 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.921313e-01 0.050 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.921313e-01 0.050 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.944092e-01 0.048 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.944092e-01 0.048 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.944092e-01 0.048 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.954862e-01 0.048 0 0
DAP12 interactions R-HSA-2172127 8.967472e-01 0.047 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.967472e-01 0.047 0 0
Methylation R-HSA-156581 8.967472e-01 0.047 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.967472e-01 0.047 0 0
Extracellular matrix organization R-HSA-1474244 8.980239e-01 0.047 0 0
Neddylation R-HSA-8951664 9.004160e-01 0.046 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.011658e-01 0.045 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.011658e-01 0.045 0 0
DAG and IP3 signaling R-HSA-1489509 9.011658e-01 0.045 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.011658e-01 0.045 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.011658e-01 0.045 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.011658e-01 0.045 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.032873e-01 0.044 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.053956e-01 0.043 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.053956e-01 0.043 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.053956e-01 0.043 0 0
Ribosome-associated quality control R-HSA-9948299 9.057443e-01 0.043 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.064782e-01 0.043 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.064782e-01 0.043 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.064782e-01 0.043 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.094446e-01 0.041 0 0
Metal ion SLC transporters R-HSA-425410 9.133206e-01 0.039 0 0
DNA Damage Bypass R-HSA-73893 9.170309e-01 0.038 0 0
Late Phase of HIV Life Cycle R-HSA-162599 9.179726e-01 0.037 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.205826e-01 0.036 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.222510e-01 0.035 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.222510e-01 0.035 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.224532e-01 0.035 0 0
Metabolism of proteins R-HSA-392499 9.236339e-01 0.035 0 0
Complex IV assembly R-HSA-9864848 9.239824e-01 0.034 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.239824e-01 0.034 0 0
mRNA 3'-end processing R-HSA-72187 9.272369e-01 0.033 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.272369e-01 0.033 0 0
Keratinization R-HSA-6805567 9.285047e-01 0.032 0 0
Metabolism of nucleotides R-HSA-15869 9.293007e-01 0.032 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.303523e-01 0.031 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.303523e-01 0.031 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.303523e-01 0.031 0 0
Phospholipid metabolism R-HSA-1483257 9.312279e-01 0.031 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.320579e-01 0.031 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.333345e-01 0.030 0 0
Infectious disease R-HSA-5663205 9.341218e-01 0.030 1 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.344411e-01 0.029 0 0
Potential therapeutics for SARS R-HSA-9679191 9.346059e-01 0.029 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.361891e-01 0.029 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.367450e-01 0.028 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.372193e-01 0.028 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.382565e-01 0.028 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.389217e-01 0.027 0 0
Ion homeostasis R-HSA-5578775 9.389217e-01 0.027 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.389217e-01 0.027 0 0
Mitochondrial protein degradation R-HSA-9837999 9.411244e-01 0.026 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.415374e-01 0.026 0 0
Dual incision in TC-NER R-HSA-6782135 9.440412e-01 0.025 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.452148e-01 0.024 0 0
Eukaryotic Translation Termination R-HSA-72764 9.452148e-01 0.024 0 0
Peroxisomal protein import R-HSA-9033241 9.464380e-01 0.024 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.464380e-01 0.024 0 0
Triglyceride metabolism R-HSA-8979227 9.464380e-01 0.024 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.464380e-01 0.024 0 0
HCMV Late Events R-HSA-9610379 9.465865e-01 0.024 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.471572e-01 0.024 0 0
Transport of small molecules R-HSA-382551 9.485604e-01 0.023 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.487322e-01 0.023 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.509284e-01 0.022 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 9.509284e-01 0.022 0 0
tRNA processing in the nucleus R-HSA-6784531 9.530305e-01 0.021 0 0
Metabolism of RNA R-HSA-8953854 9.556417e-01 0.020 0 0
Selenocysteine synthesis R-HSA-2408557 9.559239e-01 0.020 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.560840e-01 0.020 0 0
Xenobiotics R-HSA-211981 9.569689e-01 0.019 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.569689e-01 0.019 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.575018e-01 0.019 0 0
Viral mRNA Translation R-HSA-192823 9.590256e-01 0.018 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.605775e-01 0.017 0 0
Nicotinate metabolism R-HSA-196807 9.622668e-01 0.017 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.626799e-01 0.017 0 0
rRNA processing R-HSA-72312 9.632161e-01 0.016 0 0
O-linked glycosylation of mucins R-HSA-913709 9.638838e-01 0.016 0 0
Transcription of the HIV genome R-HSA-167172 9.638838e-01 0.016 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.658913e-01 0.015 0 0
Metabolism of cofactors R-HSA-8978934 9.683314e-01 0.014 0 0
Metabolism of porphyrins R-HSA-189445 9.683314e-01 0.014 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.696889e-01 0.013 0 0
Ca2+ pathway R-HSA-4086398 9.709882e-01 0.013 0 0
Inositol phosphate metabolism R-HSA-1483249 9.716437e-01 0.012 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.722320e-01 0.012 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.722320e-01 0.012 0 0
Signaling by ERBB4 R-HSA-1236394 9.722320e-01 0.012 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.734225e-01 0.012 0 0
Translation of Structural Proteins R-HSA-9694635 9.756527e-01 0.011 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.764549e-01 0.010 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.776961e-01 0.010 0 0
Peptide hormone metabolism R-HSA-2980736 9.781496e-01 0.010 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.787861e-01 0.009 0 0
Protein localization R-HSA-9609507 9.794899e-01 0.009 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.795681e-01 0.009 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.808314e-01 0.008 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.811919e-01 0.008 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.820862e-01 0.008 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.842943e-01 0.007 0 0
Pyruvate metabolism R-HSA-70268 9.849681e-01 0.007 0 0
Selenoamino acid metabolism R-HSA-2408522 9.858980e-01 0.006 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.864005e-01 0.006 0 0
Nucleotide catabolism R-HSA-8956319 9.866103e-01 0.006 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.873649e-01 0.006 0 0
tRNA processing R-HSA-72306 9.889234e-01 0.005 0 0
FCGR activation R-HSA-2029481 9.889424e-01 0.005 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.894171e-01 0.005 0 0
Collagen formation R-HSA-1474290 9.894171e-01 0.005 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.903063e-01 0.004 0 0
Mitochondrial translation elongation R-HSA-5389840 9.907225e-01 0.004 0 0
O-linked glycosylation R-HSA-5173105 9.908545e-01 0.004 0 0
Mitochondrial translation initiation R-HSA-5368286 9.915021e-01 0.004 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.918671e-01 0.004 0 0
Influenza Infection R-HSA-168255 9.919064e-01 0.004 0 0
Drug ADME R-HSA-9748784 9.924741e-01 0.003 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.931768e-01 0.003 0 0
Diseases of glycosylation R-HSA-3781865 9.932113e-01 0.003 0 0
Nucleotide Excision Repair R-HSA-5696398 9.940190e-01 0.003 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.949359e-01 0.002 0 0
Mitochondrial translation termination R-HSA-5419276 9.949826e-01 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.951982e-01 0.002 0 0
Antimicrobial peptides R-HSA-6803157 9.954046e-01 0.002 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.964695e-01 0.002 0 0
Metabolism of steroids R-HSA-8957322 9.974036e-01 0.001 0 0
Translation R-HSA-72766 9.976095e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.979169e-01 0.001 0 0
Cardiac conduction R-HSA-5576891 9.984001e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.987523e-01 0.001 0 0
Mitochondrial translation R-HSA-5368287 9.988749e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.991090e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.991361e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.993653e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.994188e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.995580e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.996958e-01 0.000 1 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.997000e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.997486e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.997594e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.997797e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.997797e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.997867e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.997995e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998233e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998272e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999089e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999360e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999489e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999713e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999724e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999793e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999862e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999926e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999988e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999994e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Signal transduction by L1 R-HSA-445144 1.000000e+00 0.000 1 1
Signaling by MAP2K mutants R-HSA-9652169 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Attenuation phase R-HSA-3371568 1.110223e-16 15.955 0 0
HSF1-dependent transactivation R-HSA-3371571 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.110223e-16 15.955 0 0
HSF1 activation R-HSA-3371511 4.440892e-16 15.353 0 0
Cellular responses to stress R-HSA-2262752 9.148238e-13 12.039 0 0
Cellular responses to stimuli R-HSA-8953897 3.399614e-12 11.469 0 0
Aggrephagy R-HSA-9646399 2.133068e-09 8.671 0 0
M Phase R-HSA-68886 3.115734e-09 8.506 0 0
Cell Cycle R-HSA-1640170 3.060359e-09 8.514 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.499046e-09 8.260 0 0
L1CAM interactions R-HSA-373760 1.010304e-08 7.996 1 0
Recycling pathway of L1 R-HSA-437239 1.671158e-08 7.777 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.854529e-08 7.732 1 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.962754e-08 7.402 0 0
Cell Cycle, Mitotic R-HSA-69278 5.444702e-08 7.264 0 0
Signaling by VEGF R-HSA-194138 1.582231e-07 6.801 0 0
Signal Transduction R-HSA-162582 2.050683e-07 6.688 1 0
PKR-mediated signaling R-HSA-9833482 2.524329e-07 6.598 0 0
Mitotic Prometaphase R-HSA-68877 4.015229e-07 6.396 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 8.839712e-07 6.054 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.430923e-07 6.025 0 0
Selective autophagy R-HSA-9663891 9.430923e-07 6.025 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.057894e-06 5.976 0 0
MAP kinase activation R-HSA-450294 1.624108e-06 5.789 0 0
Signalling to ERKs R-HSA-187687 1.962068e-06 5.707 1 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.105955e-06 5.677 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.680090e-06 5.572 0 0
Mitotic Anaphase R-HSA-68882 2.926031e-06 5.534 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.081389e-06 5.511 1 1
Mitotic Metaphase and Anaphase R-HSA-2555396 3.157984e-06 5.501 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.343974e-06 5.362 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.380406e-06 5.358 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.774488e-06 5.321 0 0
Autophagy R-HSA-9612973 5.237965e-06 5.281 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.469077e-06 5.262 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.626450e-06 5.250 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.725656e-06 5.242 0 0
Interleukin-17 signaling R-HSA-448424 6.471257e-06 5.189 0 0
Transport of connexons to the plasma membrane R-HSA-190872 6.574518e-06 5.182 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.276424e-06 5.082 1 1
Signaling by Interleukins R-HSA-449147 9.723835e-06 5.012 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.192820e-05 4.923 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.223216e-05 4.912 1 0
Axon guidance R-HSA-422475 1.322700e-05 4.879 1 0
Macroautophagy R-HSA-1632852 1.364010e-05 4.865 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.421345e-05 4.847 0 0
Nervous system development R-HSA-9675108 1.450265e-05 4.839 1 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.529132e-05 4.816 0 0
Post NMDA receptor activation events R-HSA-438064 1.541243e-05 4.812 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.643709e-05 4.784 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.905294e-05 4.720 1 1
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.860580e-05 4.730 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.007521e-05 4.697 1 1
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.007521e-05 4.697 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.007521e-05 4.697 1 1
Signaling by RAS mutants R-HSA-6802949 2.007521e-05 4.697 1 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.380097e-05 4.623 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.391389e-05 4.621 1 1
Separation of Sister Chromatids R-HSA-2467813 3.197285e-05 4.495 0 0
Signaling by ERBB2 R-HSA-1227986 3.420895e-05 4.466 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.391439e-05 4.357 0 0
MAP2K and MAPK activation R-HSA-5674135 4.663079e-05 4.331 1 1
Oncogenic MAPK signaling R-HSA-6802957 4.357030e-05 4.361 1 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.501482e-05 4.347 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.214432e-05 4.283 0 0
Mitotic Prophase R-HSA-68875 5.749267e-05 4.240 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.392036e-05 4.194 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.392036e-05 4.194 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.392036e-05 4.194 0 0
Cell junction organization R-HSA-446728 6.352028e-05 4.197 0 0
Gap junction trafficking R-HSA-190828 7.578391e-05 4.120 0 0
Cell-Cell communication R-HSA-1500931 8.635591e-05 4.064 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 9.463173e-05 4.024 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.463173e-05 4.024 0 0
Signal transduction by L1 R-HSA-445144 9.530985e-05 4.021 1 1
Apoptotic execution phase R-HSA-75153 1.028167e-04 3.988 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.233431e-04 3.909 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.233431e-04 3.909 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.250001e-04 3.903 1 1
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.375039e-04 3.862 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.382200e-04 3.859 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.491366e-04 3.826 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.491366e-04 3.826 0 0
p38MAPK events R-HSA-171007 1.582369e-04 3.801 0 0
Gap junction trafficking and regulation R-HSA-157858 1.584130e-04 3.800 0 0
G2/M Transition R-HSA-69275 1.640859e-04 3.785 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.703140e-04 3.769 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.703140e-04 3.769 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.792173e-04 3.747 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.798989e-04 3.745 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.798989e-04 3.745 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.866582e-04 3.729 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.140810e-04 3.669 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.963469e-04 3.707 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.140810e-04 3.669 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.177239e-04 3.662 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.177239e-04 3.662 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.247480e-04 3.648 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.341770e-04 3.630 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.388707e-04 3.622 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.393630e-04 3.621 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.758426e-04 3.559 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.867023e-04 3.543 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.707470e-04 3.431 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.523874e-04 3.453 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.749454e-04 3.426 1 0
Gap junction assembly R-HSA-190861 3.536097e-04 3.451 0 0
Myogenesis R-HSA-525793 4.200582e-04 3.377 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.340203e-04 3.362 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.986615e-04 3.302 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.986615e-04 3.302 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.031651e-04 3.298 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.399763e-04 3.268 0 0
Cilium Assembly R-HSA-5617833 5.429370e-04 3.265 0 0
Membrane Trafficking R-HSA-199991 5.761725e-04 3.239 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.500026e-04 3.187 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.500026e-04 3.187 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.500026e-04 3.187 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.500026e-04 3.187 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.500026e-04 3.187 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.500026e-04 3.187 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.500026e-04 3.187 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.500026e-04 3.187 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.500026e-04 3.187 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.500026e-04 3.187 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.500026e-04 3.187 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.883018e-04 3.230 0 0
Apoptosis R-HSA-109581 6.156641e-04 3.211 0 0
Signaling by NTRKs R-HSA-166520 6.665395e-04 3.176 1 0
mRNA Splicing - Major Pathway R-HSA-72163 6.831975e-04 3.165 0 0
Cellular Senescence R-HSA-2559583 7.585636e-04 3.120 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.662140e-04 3.116 0 0
Frs2-mediated activation R-HSA-170968 7.662140e-04 3.116 1 1
MAPK family signaling cascades R-HSA-5683057 7.901890e-04 3.102 1 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.912318e-04 3.102 0 0
Signalling to RAS R-HSA-167044 8.172909e-04 3.088 0 0
Interferon Signaling R-HSA-913531 8.456534e-04 3.073 0 0
Developmental Cell Lineages R-HSA-9734767 8.599833e-04 3.066 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 8.602141e-04 3.065 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 8.602141e-04 3.065 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 9.862274e-04 3.006 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.056968e-03 2.976 0 0
Developmental Biology R-HSA-1266738 1.126197e-03 2.948 1 0
AURKA Activation by TPX2 R-HSA-8854518 1.168330e-03 2.932 0 0
mTORC1-mediated signalling R-HSA-166208 1.190716e-03 2.924 0 0
mRNA Splicing R-HSA-72172 1.240822e-03 2.906 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.249991e-03 2.903 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.249991e-03 2.903 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.249991e-03 2.903 0 0
Programmed Cell Death R-HSA-5357801 1.306811e-03 2.884 0 0
Prolonged ERK activation events R-HSA-169893 1.562532e-03 2.806 1 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.648221e-03 2.783 0 0
Regulation of CDH1 Function R-HSA-9764561 1.721007e-03 2.764 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.742300e-03 2.759 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.773848e-03 2.751 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.818039e-03 2.740 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.899850e-03 2.721 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.928995e-03 2.715 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.979745e-03 2.703 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.979745e-03 2.703 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.054820e-03 2.687 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.244838e-03 2.649 0 0
MHC class II antigen presentation R-HSA-2132295 1.956010e-03 2.709 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.264198e-03 2.645 0 0
Kinesins R-HSA-983189 2.322224e-03 2.634 0 0
Cell-cell junction organization R-HSA-421270 2.349858e-03 2.629 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.354613e-03 2.628 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.452627e-03 2.610 0 0
Adherens junctions interactions R-HSA-418990 2.476848e-03 2.606 0 0
Centrosome maturation R-HSA-380287 2.667214e-03 2.574 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.844675e-03 2.546 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.844675e-03 2.546 0 0
Interleukin-12 signaling R-HSA-9020591 2.901022e-03 2.537 0 0
Cell Cycle Checkpoints R-HSA-69620 3.171445e-03 2.499 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.180879e-03 2.497 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.180879e-03 2.497 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.186723e-03 2.497 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.186723e-03 2.497 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.186723e-03 2.497 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.186723e-03 2.497 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.186723e-03 2.497 0 0
Protein folding R-HSA-391251 3.850590e-03 2.414 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.583150e-03 2.339 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.039395e-03 2.394 0 0
ERK/MAPK targets R-HSA-198753 4.754651e-03 2.323 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.597617e-03 2.337 1 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.406227e-03 2.356 0 0
Signaling by ALK in cancer R-HSA-9700206 4.406227e-03 2.356 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.119225e-03 2.291 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.339584e-03 2.272 1 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.416371e-03 2.266 0 0
NRAGE signals death through JNK R-HSA-193648 5.554522e-03 2.255 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.555495e-03 2.255 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.604779e-03 2.251 0 0
Death Receptor Signaling R-HSA-73887 5.881421e-03 2.231 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.255119e-03 2.204 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.255119e-03 2.204 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.285080e-03 2.202 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.285080e-03 2.202 0 0
Signaling by LTK in cancer R-HSA-9842640 6.364998e-03 2.196 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.559810e-03 2.183 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.733359e-03 2.172 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.885895e-03 2.162 1 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.888037e-03 2.162 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 6.888037e-03 2.162 0 0
Manipulation of host energy metabolism R-HSA-9636667 6.978764e-03 2.156 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.068348e-03 2.151 0 0
Interleukin-12 family signaling R-HSA-447115 7.191108e-03 2.143 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.847313e-03 2.105 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 7.847313e-03 2.105 0 0
DCC mediated attractive signaling R-HSA-418885 8.283468e-03 2.082 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.283468e-03 2.082 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 8.472702e-03 2.072 0 0
IFNG signaling activates MAPKs R-HSA-9732724 8.472702e-03 2.072 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.793887e-03 2.056 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.014641e-03 2.045 0 0
Neutrophil degranulation R-HSA-6798695 9.559741e-03 2.020 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.047917e-02 1.980 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.207670e-02 1.918 0 0
Type I hemidesmosome assembly R-HSA-446107 1.094409e-02 1.961 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.094409e-02 1.961 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.353923e-02 1.868 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.154602e-02 1.938 0 0
ESR-mediated signaling R-HSA-8939211 1.139903e-02 1.943 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.160176e-02 1.935 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.378966e-02 1.860 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.397430e-02 1.855 0 0
Smooth Muscle Contraction R-HSA-445355 1.411222e-02 1.850 0 0
Toll-like Receptor Cascades R-HSA-168898 1.492651e-02 1.826 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.552034e-02 1.809 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.552857e-02 1.809 0 0
Signal attenuation R-HSA-74749 1.701676e-02 1.769 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.701676e-02 1.769 0 0
Josephin domain DUBs R-HSA-5689877 1.701676e-02 1.769 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.709029e-02 1.767 0 0
Chromatin organization R-HSA-4839726 1.744175e-02 1.758 0 0
Vesicle-mediated transport R-HSA-5653656 1.745012e-02 1.758 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.800226e-02 1.745 0 0
Hedgehog 'off' state R-HSA-5610787 1.806076e-02 1.743 0 0
Glycolysis R-HSA-70171 1.806076e-02 1.743 0 0
MTOR signalling R-HSA-165159 1.835203e-02 1.736 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.836966e-02 1.736 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.920578e-02 1.717 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.026858e-02 1.693 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.065688e-02 1.685 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.328320e-02 1.633 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.355024e-02 1.628 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.355024e-02 1.628 0 0
Integrin signaling R-HSA-354192 2.357049e-02 1.628 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.371250e-02 1.625 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.575357e-02 1.589 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.624046e-02 1.581 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.624046e-02 1.581 0 0
EPH-Ephrin signaling R-HSA-2682334 2.703415e-02 1.568 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.755060e-02 1.560 0 0
RAF activation R-HSA-5673000 2.836177e-02 1.547 1 1
NOD1/2 Signaling Pathway R-HSA-168638 2.836177e-02 1.547 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.844778e-02 1.546 0 0
Semaphorin interactions R-HSA-373755 2.906337e-02 1.537 0 0
Signaling by PTK6 R-HSA-8848021 2.906337e-02 1.537 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.906337e-02 1.537 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.941291e-02 1.531 1 0
Intraflagellar transport R-HSA-5620924 2.965359e-02 1.528 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.965359e-02 1.528 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.098555e-02 1.509 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.107693e-02 1.508 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.268480e-02 1.486 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.280274e-02 1.484 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.303107e-02 1.481 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.413078e-02 1.467 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.379358e-02 1.471 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.288879e-02 1.368 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.454950e-02 1.462 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.196751e-02 1.377 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.372852e-02 1.472 0 0
HCMV Early Events R-HSA-9609690 3.506773e-02 1.455 0 0
Long-term potentiation R-HSA-9620244 4.024001e-02 1.395 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.663249e-02 1.436 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.288879e-02 1.368 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.923844e-02 1.406 0 0
Protein methylation R-HSA-8876725 4.447814e-02 1.352 0 0
Metabolism of RNA R-HSA-8953854 4.033383e-02 1.394 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.052774e-02 1.392 0 0
HDMs demethylate histones R-HSA-3214842 4.024001e-02 1.395 0 0
RUNX2 regulates bone development R-HSA-8941326 3.372852e-02 1.472 0 0
Chromatin modifying enzymes R-HSA-3247509 3.631197e-02 1.440 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.447814e-02 1.352 0 0
Immune System R-HSA-168256 3.518352e-02 1.454 0 0
Translation initiation complex formation R-HSA-72649 4.476388e-02 1.349 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.624320e-02 1.335 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.624320e-02 1.335 0 0
Glucose metabolism R-HSA-70326 4.695435e-02 1.328 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.853764e-02 1.314 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.892924e-02 1.310 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.946364e-02 1.306 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.963034e-02 1.304 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.974937e-02 1.303 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.037559e-02 1.298 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.037559e-02 1.298 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.069807e-02 1.295 0 0
Signaling by EGFR R-HSA-177929 5.069807e-02 1.295 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.069807e-02 1.295 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.350443e-02 1.272 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.350443e-02 1.272 0 0
CREB phosphorylation R-HSA-199920 5.350443e-02 1.272 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.350443e-02 1.272 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.663211e-02 1.247 0 0
Ca-dependent events R-HSA-111996 5.721819e-02 1.242 0 0
HCMV Infection R-HSA-9609646 5.745047e-02 1.241 0 0
Late endosomal microautophagy R-HSA-9615710 5.774955e-02 1.238 0 0
Signaling by Hedgehog R-HSA-5358351 5.854309e-02 1.233 0 0
PTEN Regulation R-HSA-6807070 6.067239e-02 1.217 0 0
HIV Life Cycle R-HSA-162587 6.103434e-02 1.214 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.118080e-02 1.213 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.323800e-02 1.199 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.323800e-02 1.199 0 0
Signaling by Hippo R-HSA-2028269 6.323800e-02 1.199 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.323800e-02 1.199 1 1
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.394770e-02 1.194 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.433460e-02 1.192 0 0
EGFR downregulation R-HSA-182971 6.780438e-02 1.169 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.969506e-02 1.157 0 0
Ephrin signaling R-HSA-3928664 7.018263e-02 1.154 0 0
GAB1 signalosome R-HSA-180292 7.018263e-02 1.154 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.314902e-02 1.136 0 0
Signaling by FGFR2 R-HSA-5654738 7.374425e-02 1.132 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.397594e-02 1.131 0 0
phospho-PLA2 pathway R-HSA-111995 7.582492e-02 1.120 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.582492e-02 1.120 0 0
Formation of annular gap junctions R-HSA-196025 7.582492e-02 1.120 0 0
RSK activation R-HSA-444257 7.582492e-02 1.120 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.582492e-02 1.120 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.745452e-02 1.111 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.745452e-02 1.111 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.854049e-02 1.105 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.870096e-02 1.104 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.870096e-02 1.104 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 7.882164e-02 1.103 0 0
Inhibition of PKR R-HSA-169131 7.882164e-02 1.103 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.158745e-01 0.936 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.158745e-01 0.936 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.158745e-01 0.936 0 0
Gap junction degradation R-HSA-190873 8.790493e-02 1.056 0 0
MAPK1 (ERK2) activation R-HSA-112411 8.790493e-02 1.056 1 1
Binding and entry of HIV virion R-HSA-173107 1.005088e-01 0.998 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.005088e-01 0.998 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.005088e-01 0.998 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.005088e-01 0.998 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.135750e-01 0.945 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 8.504154e-02 1.070 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 9.293097e-02 1.032 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 9.293097e-02 1.032 0 0
FGFR2 alternative splicing R-HSA-6803529 1.095640e-01 0.960 0 0
Striated Muscle Contraction R-HSA-390522 8.445656e-02 1.073 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.445656e-02 1.073 0 0
mRNA 3'-end processing R-HSA-72187 1.035452e-01 0.985 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.089689e-01 0.963 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.141996e-02 1.039 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.141996e-02 1.039 0 0
Nucleotide Excision Repair R-HSA-5696398 1.128178e-01 0.948 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.504154e-02 1.070 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.811521e-02 1.055 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.504154e-02 1.070 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.005088e-01 0.998 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.011096e-01 0.995 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.098415e-01 0.959 0 0
Calcineurin activates NFAT R-HSA-2025928 8.790493e-02 1.056 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 1.168583e-01 0.932 0 0
Parasite infection R-HSA-9664407 1.168583e-01 0.932 0 0
Leishmania phagocytosis R-HSA-9664417 1.168583e-01 0.932 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.656238e-02 1.015 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.155167e-01 0.937 0 0
Unwinding of DNA R-HSA-176974 8.790493e-02 1.056 0 0
Bicarbonate transporters R-HSA-425381 1.135750e-01 0.945 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.158745e-01 0.936 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.098415e-01 0.959 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 8.790493e-02 1.056 0 0
Suppression of apoptosis R-HSA-9635465 1.135750e-01 0.945 0 0
PECAM1 interactions R-HSA-210990 1.135750e-01 0.945 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 9.656238e-02 1.015 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 8.790493e-02 1.056 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.005088e-01 0.998 0 0
RET signaling R-HSA-8853659 1.029036e-01 0.988 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.051107e-01 0.978 0 0
Gluconeogenesis R-HSA-70263 8.325277e-02 1.080 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.095640e-01 0.960 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 8.790493e-02 1.056 0 0
Syndecan interactions R-HSA-3000170 1.182802e-01 0.927 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.005088e-01 0.998 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.182802e-01 0.927 0 0
Mitochondrial biogenesis R-HSA-1592230 9.466455e-02 1.024 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.597618e-02 1.018 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.079859e-01 0.967 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.293097e-02 1.032 0 0
Formation of apoptosome R-HSA-111458 1.005088e-01 0.998 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.083042e-01 0.965 0 0
Growth hormone receptor signaling R-HSA-982772 1.182802e-01 0.927 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.035452e-01 0.985 1 0
Epigenetic regulation of gene expression R-HSA-212165 1.194219e-01 0.923 0 0
Transmission across Chemical Synapses R-HSA-112315 1.194219e-01 0.923 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.196234e-01 0.922 0 0
Signaling by NOTCH R-HSA-157118 1.214193e-01 0.916 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.230201e-01 0.910 0 0
Signaling by ERBB4 R-HSA-1236394 1.246713e-01 0.904 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.246713e-01 0.904 0 0
Signaling by NOTCH4 R-HSA-9013694 1.246713e-01 0.904 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.249497e-01 0.903 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.260425e-01 0.899 0 0
TNF signaling R-HSA-75893 1.260425e-01 0.899 0 0
ERKs are inactivated R-HSA-202670 1.270460e-01 0.896 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 1.270460e-01 0.896 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.270460e-01 0.896 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.270460e-01 0.896 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.270460e-01 0.896 0 0
Deadenylation of mRNA R-HSA-429947 1.272443e-01 0.895 0 0
Innate Immune System R-HSA-168249 1.292324e-01 0.889 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 1.300717e-01 0.886 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.300717e-01 0.886 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.310681e-01 0.883 0 0
G2/M Checkpoints R-HSA-69481 1.346672e-01 0.871 0 0
UCH proteinases R-HSA-5689603 1.350728e-01 0.869 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.372868e-01 0.862 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.380652e-01 0.860 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.398811e-01 0.854 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.408684e-01 0.851 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.408684e-01 0.851 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.408684e-01 0.851 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.408684e-01 0.851 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 1.408684e-01 0.851 0 0
Cellular response to chemical stress R-HSA-9711123 1.409943e-01 0.851 0 0
HIV Infection R-HSA-162906 1.441910e-01 0.841 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 1.446593e-01 0.840 0 0
HIV Transcription Initiation R-HSA-167161 1.446593e-01 0.840 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 1.446593e-01 0.840 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.458593e-01 0.836 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.458593e-01 0.836 0 0
G alpha (12/13) signalling events R-HSA-416482 1.458693e-01 0.836 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.469029e-01 0.833 0 0
Sensory processing of sound R-HSA-9659379 1.514106e-01 0.820 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.514391e-01 0.820 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 1.514391e-01 0.820 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 1.514391e-01 0.820 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.514391e-01 0.820 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 1.514391e-01 0.820 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 1.514391e-01 0.820 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.521830e-01 0.818 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.549922e-01 0.810 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.554818e-01 0.808 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.554818e-01 0.808 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.554818e-01 0.808 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.855752e-01 0.731 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.855752e-01 0.731 0 0
MET activates PTPN11 R-HSA-8865999 1.855752e-01 0.731 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.855752e-01 0.731 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.855752e-01 0.731 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.183400e-01 0.661 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.183400e-01 0.661 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.183400e-01 0.661 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.183400e-01 0.661 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.183400e-01 0.661 0 0
IRS activation R-HSA-74713 2.497886e-01 0.602 0 0
Defective F9 activation R-HSA-9673221 2.497886e-01 0.602 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 2.497886e-01 0.602 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.497886e-01 0.602 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 2.497886e-01 0.602 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.799738e-01 0.553 0 0
Plus-strand DNA synthesis R-HSA-164525 2.799738e-01 0.553 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.799738e-01 0.553 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.799738e-01 0.553 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.799738e-01 0.553 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.799738e-01 0.553 0 0
Signaling by MAPK mutants R-HSA-9652817 2.799738e-01 0.553 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.089462e-01 0.510 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.089462e-01 0.510 0 0
Uncoating of the HIV Virion R-HSA-162585 3.089462e-01 0.510 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.839610e-01 0.735 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.839610e-01 0.735 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.136185e-01 0.670 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.652955e-01 0.782 0 0
HIV elongation arrest and recovery R-HSA-167287 1.652955e-01 0.782 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.652955e-01 0.782 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.652955e-01 0.782 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 2.587771e-01 0.587 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 2.738882e-01 0.562 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 1.598515e-01 0.796 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 1.755976e-01 0.755 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.836620e-01 0.736 0 0
Dual Incision in GG-NER R-HSA-5696400 2.381838e-01 0.623 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.001404e-01 0.699 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.343093e-01 0.630 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.430653e-01 0.614 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.041584e-01 0.517 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.041584e-01 0.517 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.041584e-01 0.517 0 0
Transcription of the HIV genome R-HSA-167172 2.048657e-01 0.689 0 0
HIV Transcription Elongation R-HSA-167169 3.041584e-01 0.517 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.853801e-01 0.545 0 0
Killing mechanisms R-HSA-9664420 1.987227e-01 0.702 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 1.987227e-01 0.702 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.041584e-01 0.517 0 0
G0 and Early G1 R-HSA-1538133 2.061824e-01 0.686 0 0
MET promotes cell motility R-HSA-8875878 2.819832e-01 0.550 0 0
COPII-mediated vesicle transport R-HSA-204005 2.193556e-01 0.659 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.930569e-01 0.533 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.497886e-01 0.602 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.799738e-01 0.553 0 0
Budding and maturation of HIV virion R-HSA-162588 1.957432e-01 0.708 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.889845e-01 0.539 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.497886e-01 0.602 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.264678e-01 0.645 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.799738e-01 0.553 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.693708e-01 0.771 0 0
DNA strand elongation R-HSA-69190 2.061824e-01 0.686 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.061824e-01 0.686 0 0
Regulation of Apoptosis R-HSA-169911 2.490366e-01 0.604 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.864436e-01 0.729 0 0
Degradation of DVL R-HSA-4641258 2.709478e-01 0.567 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.640486e-01 0.785 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 1.855752e-01 0.731 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.855752e-01 0.731 0 0
Suppression of autophagy R-HSA-9636569 2.497886e-01 0.602 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.799738e-01 0.553 0 0
Regulation of KIT signaling R-HSA-1433559 1.693708e-01 0.771 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.089462e-01 0.510 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.839610e-01 0.735 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.587771e-01 0.587 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.569971e-01 0.804 0 0
Orc1 removal from chromatin R-HSA-68949 2.343093e-01 0.630 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.819832e-01 0.550 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.416484e-01 0.617 0 0
PCP/CE pathway R-HSA-4086400 2.800203e-01 0.553 0 0
FCERI mediated MAPK activation R-HSA-2871796 2.505640e-01 0.601 0 0
Signaling by FGFR R-HSA-190236 1.650063e-01 0.782 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.693708e-01 0.771 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.598515e-01 0.796 0 0
Platelet degranulation R-HSA-114608 2.321178e-01 0.634 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.727346e-01 0.564 0 0
Insulin receptor signalling cascade R-HSA-74751 1.769234e-01 0.752 0 0
Signaling by FGFR4 R-HSA-5654743 1.598515e-01 0.796 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.041584e-01 0.517 0 0
Regulation of signaling by CBL R-HSA-912631 2.587771e-01 0.587 0 0
Rap1 signalling R-HSA-392517 2.587771e-01 0.587 0 0
TBC/RABGAPs R-HSA-8854214 1.598515e-01 0.796 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.167441e-01 0.664 0 0
Signaling by FGFR3 R-HSA-5654741 1.755976e-01 0.755 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 2.799738e-01 0.553 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 1.662168e-01 0.779 0 0
RAB geranylgeranylation R-HSA-8873719 3.060247e-01 0.514 0 0
Signaling by FGFR in disease R-HSA-1226099 2.492119e-01 0.603 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.784241e-01 0.555 0 0
Signaling by FGFR1 R-HSA-5654736 2.697413e-01 0.569 0 0
Activation of BH3-only proteins R-HSA-114452 1.854400e-01 0.732 0 0
Parasitic Infection Pathways R-HSA-9824443 2.595612e-01 0.586 0 0
Leishmania infection R-HSA-9658195 2.595612e-01 0.586 0 0
PERK regulates gene expression R-HSA-381042 2.490366e-01 0.604 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 2.697413e-01 0.569 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.167441e-01 0.664 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.930569e-01 0.533 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.193556e-01 0.659 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.041584e-01 0.517 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.628943e-01 0.580 0 0
DNA Repair R-HSA-73894 2.229308e-01 0.652 0 0
Gene expression (Transcription) R-HSA-74160 2.087905e-01 0.680 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.598275e-01 0.796 0 0
Oncogene Induced Senescence R-HSA-2559585 2.490366e-01 0.604 0 0
Rab regulation of trafficking R-HSA-9007101 2.944094e-01 0.531 0 0
RNA Polymerase II Transcription R-HSA-73857 2.983011e-01 0.525 0 0
Netrin-1 signaling R-HSA-373752 1.676586e-01 0.776 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.652955e-01 0.782 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.752862e-01 0.756 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.381838e-01 0.623 0 0
Signaling by FGFR2 in disease R-HSA-5655253 2.170406e-01 0.663 0 0
Muscle contraction R-HSA-397014 1.640037e-01 0.785 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.163888e-01 0.665 0 0
The NLRP3 inflammasome R-HSA-844456 2.587771e-01 0.587 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.167441e-01 0.664 0 0
Signaling by TGFB family members R-HSA-9006936 3.111421e-01 0.507 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.183400e-01 0.661 0 0
PLC beta mediated events R-HSA-112043 1.569971e-01 0.804 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.568349e-01 0.590 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.327444e-01 0.633 0 0
Platelet sensitization by LDL R-HSA-432142 2.436765e-01 0.613 0 0
Calmodulin induced events R-HSA-111933 2.599618e-01 0.585 0 0
FLT3 signaling in disease R-HSA-9682385 2.599618e-01 0.585 0 0
CaM pathway R-HSA-111997 2.599618e-01 0.585 0 0
Interleukin-38 signaling R-HSA-9007892 2.183400e-01 0.661 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.799738e-01 0.553 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.799738e-01 0.553 0 0
Leukotriene receptors R-HSA-391906 3.089462e-01 0.510 0 0
Viral Infection Pathways R-HSA-9824446 2.993358e-01 0.524 0 0
G-protein mediated events R-HSA-112040 1.977445e-01 0.704 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.436765e-01 0.613 0 0
RMTs methylate histone arginines R-HSA-3214858 1.676586e-01 0.776 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.755976e-01 0.755 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.755976e-01 0.755 0 0
Formation of definitive endoderm R-HSA-9823730 2.738882e-01 0.562 0 0
Interleukin-1 family signaling R-HSA-446652 2.673635e-01 0.573 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.072473e-01 0.513 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.693708e-01 0.771 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.035959e-01 0.518 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.787479e-01 0.555 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.697413e-01 0.569 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.961897e-01 0.707 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.274155e-01 0.643 0 0
Specification of primordial germ cells R-HSA-9827857 2.286138e-01 0.641 0 0
Signaling by Activin R-HSA-1502540 1.839610e-01 0.735 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.040429e-01 0.517 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.839610e-01 0.735 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.436765e-01 0.613 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.587771e-01 0.587 0 0
Signaling by NODAL R-HSA-1181150 2.738882e-01 0.562 0 0
Regulation of TP53 Activity R-HSA-5633007 3.111421e-01 0.507 0 0
IRE1alpha activates chaperones R-HSA-381070 2.376286e-01 0.624 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.836620e-01 0.736 0 0
DNA Damage Reversal R-HSA-73942 1.839610e-01 0.735 0 0
Apoptotic factor-mediated response R-HSA-111471 2.436765e-01 0.613 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 2.930569e-01 0.533 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.115226e-01 0.507 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.135492e-01 0.504 0 0
Interleukin-1 signaling R-HSA-9020702 3.135492e-01 0.504 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.151824e-01 0.501 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 3.152774e-01 0.501 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.152774e-01 0.501 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.152774e-01 0.501 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.152774e-01 0.501 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.152774e-01 0.501 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 3.190419e-01 0.496 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.190419e-01 0.496 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.190419e-01 0.496 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.190419e-01 0.496 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.195947e-01 0.495 0 0
Chromosome Maintenance R-HSA-73886 3.201926e-01 0.495 0 0
NCAM signaling for neurite out-growth R-HSA-375165 3.243631e-01 0.489 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.243631e-01 0.489 0 0
Heme signaling R-HSA-9707616 3.243631e-01 0.489 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.264040e-01 0.486 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.264040e-01 0.486 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.264040e-01 0.486 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.335611e-01 0.477 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.339620e-01 0.476 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.339620e-01 0.476 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.339620e-01 0.476 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.349604e-01 0.475 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.349604e-01 0.475 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.367545e-01 0.473 0 0
SOS-mediated signalling R-HSA-112412 3.367545e-01 0.473 0 0
Recycling of eIF2:GDP R-HSA-72731 3.367545e-01 0.473 0 0
Disinhibition of SNARE formation R-HSA-114516 3.367545e-01 0.473 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 3.367545e-01 0.473 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.367545e-01 0.473 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.367545e-01 0.473 0 0
VLDL clearance R-HSA-8964046 3.367545e-01 0.473 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.367545e-01 0.473 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.367545e-01 0.473 0 0
CHL1 interactions R-HSA-447041 3.367545e-01 0.473 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.367545e-01 0.473 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.367545e-01 0.473 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.368506e-01 0.473 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.375288e-01 0.472 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.434677e-01 0.464 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.486426e-01 0.458 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.487854e-01 0.457 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.487854e-01 0.457 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.487854e-01 0.457 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.487854e-01 0.457 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.514948e-01 0.454 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.514948e-01 0.454 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.514948e-01 0.454 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.565338e-01 0.448 0 0
Neuronal System R-HSA-112316 3.612249e-01 0.442 0 0
Reverse Transcription of HIV RNA R-HSA-162589 3.634454e-01 0.440 0 0
Minus-strand DNA synthesis R-HSA-164516 3.634454e-01 0.440 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.634454e-01 0.440 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.634454e-01 0.440 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.634454e-01 0.440 0 0
MET receptor recycling R-HSA-8875656 3.634454e-01 0.440 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.634454e-01 0.440 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.634454e-01 0.440 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.634454e-01 0.440 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.634454e-01 0.440 0 0
Adrenoceptors R-HSA-390696 3.634454e-01 0.440 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.634454e-01 0.440 0 0
Sodium/Proton exchangers R-HSA-425986 3.634454e-01 0.440 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.634454e-01 0.440 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 3.634957e-01 0.440 0 0
TGFBR3 expression R-HSA-9839394 3.634957e-01 0.440 0 0
Tight junction interactions R-HSA-420029 3.634957e-01 0.440 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.634957e-01 0.440 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 3.634957e-01 0.440 0 0
Synthesis of DNA R-HSA-69239 3.637485e-01 0.439 0 0
Asparagine N-linked glycosylation R-HSA-446203 3.644801e-01 0.438 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.708027e-01 0.431 0 0
Nucleosome assembly R-HSA-774815 3.708027e-01 0.431 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 3.708027e-01 0.431 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 3.708027e-01 0.431 0 0
DAG and IP3 signaling R-HSA-1489509 3.708027e-01 0.431 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.780779e-01 0.422 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.780779e-01 0.422 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.780779e-01 0.422 0 0
TRP channels R-HSA-3295583 3.780779e-01 0.422 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.796206e-01 0.421 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.818327e-01 0.418 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.818327e-01 0.418 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.818327e-01 0.418 0 0
Signaling by TGFBR3 R-HSA-9839373 3.818327e-01 0.418 0 0
Hemostasis R-HSA-109582 3.879094e-01 0.411 0 0
Lipophagy R-HSA-9613354 3.890637e-01 0.410 0 0
WNT mediated activation of DVL R-HSA-201688 3.890637e-01 0.410 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.890637e-01 0.410 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.890637e-01 0.410 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.890637e-01 0.410 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.890637e-01 0.410 0 0
Interleukin-1 processing R-HSA-448706 3.890637e-01 0.410 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.890637e-01 0.410 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.890637e-01 0.410 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.890637e-01 0.410 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.916964e-01 0.407 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.925187e-01 0.406 0 0
Signaling by FGFR3 in disease R-HSA-5655332 3.925187e-01 0.406 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.925187e-01 0.406 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.928192e-01 0.406 0 0
Co-stimulation by CD28 R-HSA-389356 4.037548e-01 0.394 0 0
NGF-stimulated transcription R-HSA-9031628 4.037548e-01 0.394 0 0
Circadian clock R-HSA-9909396 4.058195e-01 0.392 0 0
Inflammasomes R-HSA-622312 4.068058e-01 0.391 0 0
Hedgehog 'on' state R-HSA-5632684 4.071296e-01 0.390 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.077446e-01 0.390 0 0
Signaling by Insulin receptor R-HSA-74752 4.077446e-01 0.390 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.136526e-01 0.383 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.136526e-01 0.383 0 0
PI3K/AKT activation R-HSA-198203 4.136526e-01 0.383 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.136526e-01 0.383 0 0
Regulation of CDH11 function R-HSA-9762292 4.136526e-01 0.383 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.136526e-01 0.383 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.136526e-01 0.383 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 4.136526e-01 0.383 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.136526e-01 0.383 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.136526e-01 0.383 0 0
Signaling by Leptin R-HSA-2586552 4.136526e-01 0.383 0 0
DNA Damage Bypass R-HSA-73893 4.146328e-01 0.382 0 0
Degradation of CDH1 R-HSA-9766229 4.146328e-01 0.382 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.157488e-01 0.381 0 0
Signaling by Erythropoietin R-HSA-9006335 4.209282e-01 0.376 0 0
mRNA Capping R-HSA-72086 4.209282e-01 0.376 0 0
DNA methylation R-HSA-5334118 4.209282e-01 0.376 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.209282e-01 0.376 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.209282e-01 0.376 0 0
Influenza Infection R-HSA-168255 4.253601e-01 0.371 0 0
PI3K Cascade R-HSA-109704 4.254466e-01 0.371 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 4.275400e-01 0.369 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.287218e-01 0.368 0 0
Signaling by WNT R-HSA-195721 4.328750e-01 0.364 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.343908e-01 0.362 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.348761e-01 0.362 0 0
Activation of the pre-replicative complex R-HSA-68962 4.348761e-01 0.362 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.348761e-01 0.362 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.348761e-01 0.362 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.348761e-01 0.362 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.348761e-01 0.362 0 0
Interleukin-37 signaling R-HSA-9008059 4.348761e-01 0.362 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.361900e-01 0.360 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.361900e-01 0.360 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.372532e-01 0.359 0 0
vRNA Synthesis R-HSA-192814 4.372532e-01 0.359 0 0
vRNP Assembly R-HSA-192905 4.372532e-01 0.359 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.372532e-01 0.359 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.372532e-01 0.359 0 0
Interleukin-2 signaling R-HSA-9020558 4.372532e-01 0.359 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.372532e-01 0.359 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.388502e-01 0.358 0 0
Generic Transcription Pathway R-HSA-212436 4.446161e-01 0.352 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.454279e-01 0.351 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.468574e-01 0.350 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.468574e-01 0.350 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.468574e-01 0.350 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.468574e-01 0.350 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.468574e-01 0.350 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.486406e-01 0.348 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.486406e-01 0.348 0 0
Trafficking of AMPA receptors R-HSA-399719 4.486406e-01 0.348 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.486406e-01 0.348 0 0
Cargo concentration in the ER R-HSA-5694530 4.486406e-01 0.348 0 0
Deubiquitination R-HSA-5688426 4.553972e-01 0.342 0 0
Homology Directed Repair R-HSA-5693538 4.573371e-01 0.340 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.574431e-01 0.340 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.574431e-01 0.340 0 0
Meiotic synapsis R-HSA-1221632 4.574431e-01 0.340 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.599053e-01 0.337 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.599053e-01 0.337 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.599053e-01 0.337 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 4.599053e-01 0.337 0 0
Activation of RAC1 R-HSA-428540 4.599053e-01 0.337 0 0
Integration of provirus R-HSA-162592 4.599053e-01 0.337 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.622139e-01 0.335 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.622139e-01 0.335 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.679420e-01 0.330 0 0
FOXO-mediated transcription R-HSA-9614085 4.711340e-01 0.327 0 0
Extracellular matrix organization R-HSA-1474244 4.731879e-01 0.325 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.755891e-01 0.323 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.755891e-01 0.323 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.755891e-01 0.323 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.755891e-01 0.323 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.783494e-01 0.320 0 0
Signaling by NOTCH3 R-HSA-9012852 4.783494e-01 0.320 0 0
ABC-family proteins mediated transport R-HSA-382556 4.789214e-01 0.320 0 0
Disease R-HSA-1643685 4.814860e-01 0.317 1 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.816469e-01 0.317 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.816469e-01 0.317 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.816469e-01 0.317 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.816469e-01 0.317 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.816469e-01 0.317 0 0
Repression of WNT target genes R-HSA-4641265 4.816469e-01 0.317 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.816469e-01 0.317 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.816469e-01 0.317 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.816469e-01 0.317 0 0
Polymerase switching R-HSA-69091 4.816469e-01 0.317 0 0
Leading Strand Synthesis R-HSA-69109 4.816469e-01 0.317 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.816469e-01 0.317 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.816469e-01 0.317 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.816469e-01 0.317 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.886608e-01 0.311 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.886608e-01 0.311 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.887602e-01 0.311 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.887602e-01 0.311 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.887602e-01 0.311 0 0
Vpu mediated degradation of CD4 R-HSA-180534 4.887602e-01 0.311 0 0
Glutamate and glutamine metabolism R-HSA-8964539 4.887602e-01 0.311 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.887602e-01 0.311 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.925918e-01 0.308 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.964371e-01 0.304 0 0
IRS-mediated signalling R-HSA-112399 4.988718e-01 0.302 0 0
Host Interactions of HIV factors R-HSA-162909 4.995551e-01 0.301 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.017220e-01 0.300 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.017220e-01 0.300 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 5.017220e-01 0.300 0 0
Nuclear import of Rev protein R-HSA-180746 5.017220e-01 0.300 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 5.017220e-01 0.300 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.017220e-01 0.300 0 0
Signal amplification R-HSA-392518 5.017220e-01 0.300 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.017220e-01 0.300 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.025145e-01 0.299 0 0
Formation of axial mesoderm R-HSA-9796292 5.025145e-01 0.299 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.025145e-01 0.299 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.025145e-01 0.299 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.025145e-01 0.299 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.025145e-01 0.299 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.025145e-01 0.299 0 0
Dual incision in TC-NER R-HSA-6782135 5.089786e-01 0.293 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.096615e-01 0.293 0 0
Opioid Signalling R-HSA-111885 5.096615e-01 0.293 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.102074e-01 0.292 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.144699e-01 0.289 0 0
Transferrin endocytosis and recycling R-HSA-917977 5.144699e-01 0.289 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.144699e-01 0.289 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.144699e-01 0.289 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.144699e-01 0.289 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 5.144699e-01 0.289 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.189776e-01 0.285 0 0
snRNP Assembly R-HSA-191859 5.189776e-01 0.285 0 0
Metabolism of non-coding RNA R-HSA-194441 5.189776e-01 0.285 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.189776e-01 0.285 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 5.189776e-01 0.285 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.193498e-01 0.285 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.221404e-01 0.282 0 0
Removal of the Flap Intermediate R-HSA-69166 5.225433e-01 0.282 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.225433e-01 0.282 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.225433e-01 0.282 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.225433e-01 0.282 0 0
Hydrolysis of LPC R-HSA-1483115 5.225433e-01 0.282 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.225433e-01 0.282 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.225433e-01 0.282 0 0
Malate-aspartate shuttle R-HSA-9856872 5.225433e-01 0.282 0 0
Signal regulatory protein family interactions R-HSA-391160 5.225433e-01 0.282 0 0
Acyl chain remodeling of CL R-HSA-1482798 5.225433e-01 0.282 0 0
S Phase R-HSA-69242 5.228688e-01 0.282 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.270002e-01 0.278 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.270002e-01 0.278 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 5.270002e-01 0.278 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.270002e-01 0.278 0 0
FGFR2 mutant receptor activation R-HSA-1839126 5.270002e-01 0.278 0 0
Infectious disease R-HSA-5663205 5.323878e-01 0.274 1 0
Potential therapeutics for SARS R-HSA-9679191 5.354070e-01 0.271 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.386391e-01 0.269 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.393097e-01 0.268 0 0
Degradation of AXIN R-HSA-4641257 5.393097e-01 0.268 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.393097e-01 0.268 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.393097e-01 0.268 0 0
Gene Silencing by RNA R-HSA-211000 5.396439e-01 0.268 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.417669e-01 0.266 0 0
Erythropoietin activates RAS R-HSA-9027284 5.417669e-01 0.266 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.417669e-01 0.266 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.417669e-01 0.266 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.417669e-01 0.266 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.417669e-01 0.266 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.417669e-01 0.266 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.417669e-01 0.266 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.417669e-01 0.266 0 0
p75NTR signals via NF-kB R-HSA-193639 5.417669e-01 0.266 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.427325e-01 0.265 0 0
Mitochondrial protein import R-HSA-1268020 5.482956e-01 0.261 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.482956e-01 0.261 0 0
Signaling by PDGF R-HSA-186797 5.482956e-01 0.261 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.513960e-01 0.259 0 0
Protein localization R-HSA-9609507 5.539624e-01 0.257 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.543130e-01 0.256 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.602176e-01 0.252 0 0
Phosphorylation of the APC/C R-HSA-176412 5.602176e-01 0.252 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.602176e-01 0.252 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.602176e-01 0.252 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.602176e-01 0.252 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.602176e-01 0.252 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.602176e-01 0.252 0 0
Differentiation of T cells R-HSA-9945266 5.602176e-01 0.252 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.602176e-01 0.252 0 0
Attachment and Entry R-HSA-9678110 5.602176e-01 0.252 0 0
TCR signaling R-HSA-202403 5.615612e-01 0.251 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 5.632570e-01 0.249 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.632570e-01 0.249 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 5.632570e-01 0.249 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.632570e-01 0.249 0 0
Stabilization of p53 R-HSA-69541 5.632570e-01 0.249 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.661517e-01 0.247 0 0
IGF1R signaling cascade R-HSA-2428924 5.672474e-01 0.246 0 0
ER-Phagosome pathway R-HSA-1236974 5.715642e-01 0.243 0 0
Adaptive Immune System R-HSA-1280218 5.718884e-01 0.243 0 0
Diseases of Immune System R-HSA-5260271 5.748912e-01 0.240 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.748912e-01 0.240 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.748912e-01 0.240 0 0
Generation of second messenger molecules R-HSA-202433 5.748912e-01 0.240 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.765382e-01 0.239 0 0
Translation R-HSA-72766 5.767436e-01 0.239 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.779265e-01 0.238 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.779265e-01 0.238 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.779265e-01 0.238 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.779265e-01 0.238 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.779265e-01 0.238 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.779265e-01 0.238 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.779265e-01 0.238 0 0
Disorders of Developmental Biology R-HSA-9675151 5.779265e-01 0.238 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.779265e-01 0.238 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 5.779265e-01 0.238 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.829422e-01 0.234 0 0
Cellular response to starvation R-HSA-9711097 5.841440e-01 0.233 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.857031e-01 0.232 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.862978e-01 0.232 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.862978e-01 0.232 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.862978e-01 0.232 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.899436e-01 0.229 0 0
Interferon gamma signaling R-HSA-877300 5.900598e-01 0.229 0 0
DNA Double Strand Break Response R-HSA-5693606 5.947403e-01 0.226 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.949234e-01 0.226 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.949234e-01 0.226 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.949234e-01 0.226 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.949234e-01 0.226 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 5.949234e-01 0.226 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.949234e-01 0.226 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.949234e-01 0.226 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.974762e-01 0.224 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.974762e-01 0.224 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 5.974762e-01 0.224 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.084262e-01 0.216 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.112367e-01 0.214 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.112367e-01 0.214 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.112367e-01 0.214 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.112367e-01 0.214 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.112367e-01 0.214 0 0
Polo-like kinase mediated events R-HSA-156711 6.112367e-01 0.214 0 0
Mismatch Repair R-HSA-5358508 6.112367e-01 0.214 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.112367e-01 0.214 0 0
Mitochondrial protein degradation R-HSA-9837999 6.179958e-01 0.209 0 0
Signaling by SCF-KIT R-HSA-1433557 6.191481e-01 0.208 0 0
Defective pyroptosis R-HSA-9710421 6.191481e-01 0.208 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.210728e-01 0.207 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.210728e-01 0.207 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.268941e-01 0.203 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.268941e-01 0.203 0 0
Translesion Synthesis by POLH R-HSA-110320 6.268941e-01 0.203 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.268941e-01 0.203 0 0
Diseases of hemostasis R-HSA-9671793 6.268941e-01 0.203 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.268941e-01 0.203 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.295869e-01 0.201 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.295869e-01 0.201 0 0
Proteasome assembly R-HSA-9907900 6.296426e-01 0.201 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.296426e-01 0.201 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.327551e-01 0.199 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.379681e-01 0.195 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.379681e-01 0.195 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.399105e-01 0.194 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.399105e-01 0.194 0 0
Somitogenesis R-HSA-9824272 6.399105e-01 0.194 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.419217e-01 0.193 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.419217e-01 0.193 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.419217e-01 0.193 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.419217e-01 0.193 0 0
Acyl chain remodelling of PI R-HSA-1482922 6.419217e-01 0.193 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.419217e-01 0.193 0 0
Nephrin family interactions R-HSA-373753 6.419217e-01 0.193 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.419217e-01 0.193 0 0
Ca2+ pathway R-HSA-4086398 6.462156e-01 0.190 0 0
Telomere Maintenance R-HSA-157579 6.471423e-01 0.189 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 6.499139e-01 0.187 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.499530e-01 0.187 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.499530e-01 0.187 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.499530e-01 0.187 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.563450e-01 0.183 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.563450e-01 0.183 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.563450e-01 0.183 0 0
Lagging Strand Synthesis R-HSA-69186 6.563450e-01 0.183 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.563450e-01 0.183 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.563450e-01 0.183 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 6.563450e-01 0.183 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.563450e-01 0.183 0 0
Acyl chain remodelling of PG R-HSA-1482925 6.563450e-01 0.183 0 0
Basigin interactions R-HSA-210991 6.563450e-01 0.183 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.563450e-01 0.183 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.597718e-01 0.181 0 0
HATs acetylate histones R-HSA-3214847 6.611520e-01 0.180 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.623086e-01 0.179 0 0
Iron uptake and transport R-HSA-917937 6.623086e-01 0.179 0 0
Protein ubiquitination R-HSA-8852135 6.623086e-01 0.179 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.681178e-01 0.175 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.701537e-01 0.174 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.701882e-01 0.174 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.701882e-01 0.174 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.701882e-01 0.174 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.701882e-01 0.174 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.701882e-01 0.174 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.701882e-01 0.174 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.701882e-01 0.174 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 6.701882e-01 0.174 0 0
Attachment and Entry R-HSA-9694614 6.701882e-01 0.174 0 0
Assembly Of The HIV Virion R-HSA-175474 6.701882e-01 0.174 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.787448e-01 0.168 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.787448e-01 0.168 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.787448e-01 0.168 0 0
G1/S Transition R-HSA-69206 6.807249e-01 0.167 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.834745e-01 0.165 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.834745e-01 0.165 0 0
Notch-HLH transcription pathway R-HSA-350054 6.834745e-01 0.165 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.834745e-01 0.165 0 0
Signaling by KIT in disease R-HSA-9669938 6.834745e-01 0.165 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.834745e-01 0.165 0 0
LDL clearance R-HSA-8964038 6.834745e-01 0.165 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.834745e-01 0.165 0 0
Integrin cell surface interactions R-HSA-216083 6.854412e-01 0.164 0 0
RNA Polymerase I Transcription R-HSA-73864 6.854412e-01 0.164 0 0
ABC transporter disorders R-HSA-5619084 6.854412e-01 0.164 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.879033e-01 0.162 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.889123e-01 0.162 0 0
Signaling by ROBO receptors R-HSA-376176 6.908123e-01 0.161 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.961866e-01 0.157 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.962264e-01 0.157 0 0
Organic anion transport by SLCO transporters R-HSA-879518 6.962264e-01 0.157 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.968461e-01 0.157 0 0
Signaling by MET R-HSA-6806834 7.001933e-01 0.155 0 0
DNA Replication R-HSA-69306 7.031130e-01 0.153 0 0
Neurexins and neuroligins R-HSA-6794361 7.055758e-01 0.151 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.083153e-01 0.150 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.084653e-01 0.150 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.084653e-01 0.150 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.084653e-01 0.150 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.084653e-01 0.150 0 0
Complex III assembly R-HSA-9865881 7.084653e-01 0.150 0 0
Neurodegenerative Diseases R-HSA-8863678 7.084653e-01 0.150 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 7.084653e-01 0.150 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.140949e-01 0.146 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.140949e-01 0.146 0 0
Reproduction R-HSA-1474165 7.152292e-01 0.146 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.202118e-01 0.143 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.202118e-01 0.143 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.202118e-01 0.143 0 0
Hyaluronan degradation R-HSA-2160916 7.202118e-01 0.143 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.202118e-01 0.143 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.202118e-01 0.143 0 0
Laminin interactions R-HSA-3000157 7.202118e-01 0.143 0 0
Interleukin-7 signaling R-HSA-1266695 7.202118e-01 0.143 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.213261e-01 0.142 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.254430e-01 0.139 0 0
Stimuli-sensing channels R-HSA-2672351 7.254430e-01 0.139 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.285004e-01 0.138 0 0
G alpha (q) signalling events R-HSA-416476 7.286691e-01 0.137 0 0
G alpha (z) signalling events R-HSA-418597 7.305129e-01 0.136 0 0
MET activates PTK2 signaling R-HSA-8874081 7.314857e-01 0.136 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.314857e-01 0.136 0 0
Sphingolipid catabolism R-HSA-9845614 7.314857e-01 0.136 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.314857e-01 0.136 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.314857e-01 0.136 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.314857e-01 0.136 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.347590e-01 0.134 0 0
Meiosis R-HSA-1500620 7.347590e-01 0.134 0 0
Ion homeostasis R-HSA-5578775 7.384177e-01 0.132 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.412814e-01 0.130 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.423059e-01 0.129 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.423059e-01 0.129 0 0
Cristae formation R-HSA-8949613 7.423059e-01 0.129 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.423059e-01 0.129 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.423059e-01 0.129 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.423059e-01 0.129 0 0
Insulin processing R-HSA-264876 7.423059e-01 0.129 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.423059e-01 0.129 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.526908e-01 0.123 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.526908e-01 0.123 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.526908e-01 0.123 0 0
Pyroptosis R-HSA-5620971 7.526908e-01 0.123 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.536343e-01 0.123 0 0
Diseases of programmed cell death R-HSA-9645723 7.600849e-01 0.119 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.626578e-01 0.118 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.626578e-01 0.118 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.626578e-01 0.118 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.626578e-01 0.118 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.626578e-01 0.118 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.666539e-01 0.115 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.680817e-01 0.115 0 0
Metabolism of polyamines R-HSA-351202 7.680817e-01 0.115 0 0
SLC transporter disorders R-HSA-5619102 7.702635e-01 0.113 0 0
Neurotransmitter release cycle R-HSA-112310 7.719958e-01 0.112 0 0
Base Excision Repair R-HSA-73884 7.719958e-01 0.112 0 0
Downstream TCR signaling R-HSA-202424 7.719958e-01 0.112 0 0
DAP12 signaling R-HSA-2424491 7.722237e-01 0.112 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.722237e-01 0.112 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.722237e-01 0.112 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.722237e-01 0.112 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.722237e-01 0.112 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.736436e-01 0.111 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.750252e-01 0.111 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.750252e-01 0.111 0 0
Interferon alpha/beta signaling R-HSA-909733 7.751433e-01 0.111 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.814046e-01 0.107 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.814046e-01 0.107 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.814046e-01 0.107 0 0
Downstream signal transduction R-HSA-186763 7.814046e-01 0.107 0 0
tRNA processing in the nucleus R-HSA-6784531 7.817863e-01 0.107 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.930699e-01 0.101 0 0
Co-inhibition by PD-1 R-HSA-389948 7.941365e-01 0.100 0 0
Ion transport by P-type ATPases R-HSA-936837 7.947754e-01 0.100 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.986727e-01 0.098 0 0
G-protein beta:gamma signalling R-HSA-397795 7.986727e-01 0.098 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.986727e-01 0.098 0 0
Nuclear RNA decay R-HSA-9930044 7.986727e-01 0.098 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.986727e-01 0.098 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 7.986727e-01 0.098 0 0
Recycling of bile acids and salts R-HSA-159418 7.986727e-01 0.098 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.986727e-01 0.098 0 0
Ub-specific processing proteases R-HSA-5689880 7.992961e-01 0.097 0 0
Collagen formation R-HSA-1474290 7.996633e-01 0.097 0 0
Cellular response to hypoxia R-HSA-1234174 8.010102e-01 0.096 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.048466e-01 0.094 0 0
SARS-CoV Infections R-HSA-9679506 8.052533e-01 0.094 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.067891e-01 0.093 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.067891e-01 0.093 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.099166e-01 0.092 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.129775e-01 0.090 0 0
Signaling by NOTCH2 R-HSA-1980145 8.145787e-01 0.089 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.145787e-01 0.089 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.145787e-01 0.089 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.145787e-01 0.089 0 0
eNOS activation R-HSA-203615 8.145787e-01 0.089 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.145787e-01 0.089 0 0
Hyaluronan metabolism R-HSA-2142845 8.145787e-01 0.089 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.145787e-01 0.089 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.145787e-01 0.089 0 0
Mitophagy R-HSA-5205647 8.145787e-01 0.089 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.145787e-01 0.089 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.145787e-01 0.089 0 0
Gastrulation R-HSA-9758941 8.148122e-01 0.089 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.148751e-01 0.089 0 0
Formation of the cornified envelope R-HSA-6809371 8.174742e-01 0.088 0 0
Regulated Necrosis R-HSA-5218859 8.187169e-01 0.087 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.220547e-01 0.085 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.220547e-01 0.085 0 0
GPVI-mediated activation cascade R-HSA-114604 8.292297e-01 0.081 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.292297e-01 0.081 0 0
G1/S-Specific Transcription R-HSA-69205 8.292297e-01 0.081 0 0
Voltage gated Potassium channels R-HSA-1296072 8.361158e-01 0.078 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.361158e-01 0.078 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.361158e-01 0.078 0 0
Collagen chain trimerization R-HSA-8948216 8.361158e-01 0.078 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.427246e-01 0.074 0 0
Elastic fibre formation R-HSA-1566948 8.427246e-01 0.074 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.427246e-01 0.074 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.427246e-01 0.074 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.490674e-01 0.071 0 0
Pentose phosphate pathway R-HSA-71336 8.490674e-01 0.071 0 0
Signaling by ALK R-HSA-201556 8.490674e-01 0.071 0 0
Adipogenesis R-HSA-9843745 8.530308e-01 0.069 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.546518e-01 0.068 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.547452e-01 0.068 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.547452e-01 0.068 0 0
RSV-host interactions R-HSA-9833110 8.547452e-01 0.068 0 0
Ion channel transport R-HSA-983712 8.549413e-01 0.068 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.551547e-01 0.068 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.551547e-01 0.068 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.551547e-01 0.068 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.551547e-01 0.068 0 0
Interleukin-2 family signaling R-HSA-451927 8.551547e-01 0.068 0 0
Signaling by NOTCH1 R-HSA-1980143 8.592197e-01 0.066 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.609968e-01 0.065 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.609968e-01 0.065 0 0
FLT3 Signaling R-HSA-9607240 8.609968e-01 0.065 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.666037e-01 0.062 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.666037e-01 0.062 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.679639e-01 0.061 0 0
Interleukin-10 signaling R-HSA-6783783 8.679639e-01 0.061 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.719847e-01 0.059 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.719847e-01 0.059 0 0
Depyrimidination R-HSA-73928 8.719847e-01 0.059 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.721465e-01 0.059 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.762068e-01 0.057 0 0
Ribosome-associated quality control R-HSA-9948299 8.795313e-01 0.056 0 0
DAP12 interactions R-HSA-2172127 8.821052e-01 0.054 0 0
G1 Phase R-HSA-69236 8.821052e-01 0.054 0 0
Cyclin D associated events in G1 R-HSA-69231 8.821052e-01 0.054 0 0
Amine ligand-binding receptors R-HSA-375280 8.821052e-01 0.054 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 8.821052e-01 0.054 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.876850e-01 0.052 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.912438e-01 0.050 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.914268e-01 0.050 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.914268e-01 0.050 0 0
Diseases of DNA repair R-HSA-9675135 8.914268e-01 0.050 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.958078e-01 0.048 0 0
Metal ion SLC transporters R-HSA-425410 9.000123e-01 0.046 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.040474e-01 0.044 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.040474e-01 0.044 0 0
Pyruvate metabolism R-HSA-70268 9.046461e-01 0.044 0 0
Peptide chain elongation R-HSA-156902 9.077379e-01 0.042 0 0
Post-translational protein modification R-HSA-597592 9.107741e-01 0.041 0 0
Complex IV assembly R-HSA-9864848 9.116363e-01 0.040 0 0
The phototransduction cascade R-HSA-2514856 9.116363e-01 0.040 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.152030e-01 0.038 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.164596e-01 0.038 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.191906e-01 0.037 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.219108e-01 0.035 0 0
FCGR activation R-HSA-2029481 9.244026e-01 0.034 0 0
HDACs deacetylate histones R-HSA-3214815 9.250633e-01 0.034 0 0
Paracetamol ADME R-HSA-9753281 9.250633e-01 0.034 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.265893e-01 0.033 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.265893e-01 0.033 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.265893e-01 0.033 0 0
HCMV Late Events R-HSA-9610379 9.283771e-01 0.032 0 0
Neddylation R-HSA-8951664 9.302042e-01 0.031 0 0
Dectin-2 family R-HSA-5621480 9.309922e-01 0.031 0 0
Synthesis of PA R-HSA-1483166 9.309922e-01 0.031 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.337786e-01 0.030 0 0
Peroxisomal protein import R-HSA-9033241 9.364527e-01 0.029 0 0
Extension of Telomeres R-HSA-180786 9.364527e-01 0.029 0 0
Regulation of beta-cell development R-HSA-186712 9.364527e-01 0.029 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.364527e-01 0.029 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.382005e-01 0.028 0 0
tRNA Aminoacylation R-HSA-379724 9.390189e-01 0.027 0 0
Collagen degradation R-HSA-1442490 9.414817e-01 0.026 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.438451e-01 0.025 0 0
Complex I biogenesis R-HSA-6799198 9.461132e-01 0.024 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.461132e-01 0.024 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.461132e-01 0.024 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.510766e-01 0.022 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.543070e-01 0.020 0 0
Platelet homeostasis R-HSA-418346 9.545010e-01 0.020 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.560348e-01 0.020 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.561531e-01 0.019 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.596249e-01 0.018 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.603450e-01 0.018 0 0
ECM proteoglycans R-HSA-3000178 9.612565e-01 0.017 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.612565e-01 0.017 0 0
Metabolism of cofactors R-HSA-8978934 9.612565e-01 0.017 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.621514e-01 0.017 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.628222e-01 0.016 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.629902e-01 0.016 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.629902e-01 0.016 0 0
Inositol phosphate metabolism R-HSA-1483249 9.629902e-01 0.016 0 0
Aspirin ADME R-HSA-9749641 9.643248e-01 0.016 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.666428e-01 0.015 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.671504e-01 0.015 0 0
Peptide ligand-binding receptors R-HSA-375276 9.688254e-01 0.014 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.688826e-01 0.014 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.697525e-01 0.013 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.704680e-01 0.013 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.705634e-01 0.013 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.709754e-01 0.013 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.732749e-01 0.012 0 0
Bacterial Infection Pathways R-HSA-9824439 9.735092e-01 0.012 1 0
Amyloid fiber formation R-HSA-977225 9.743555e-01 0.011 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.748266e-01 0.011 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.795682e-01 0.009 0 0
Selenoamino acid metabolism R-HSA-2408522 9.797734e-01 0.009 0 0
Keratinization R-HSA-6805567 9.831086e-01 0.007 0 0
Cardiac conduction R-HSA-5576891 9.834797e-01 0.007 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.837168e-01 0.007 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.840566e-01 0.007 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.850080e-01 0.007 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.853223e-01 0.006 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.853223e-01 0.006 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.856147e-01 0.006 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.867556e-01 0.006 0 0
Eukaryotic Translation Termination R-HSA-72764 9.872917e-01 0.006 0 0
Respiratory electron transport R-HSA-611105 9.875175e-01 0.005 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.878061e-01 0.005 0 0
Potassium Channels R-HSA-1296071 9.878061e-01 0.005 0 0
Metabolism of proteins R-HSA-392499 9.879095e-01 0.005 0 0
Regulation of insulin secretion R-HSA-422356 9.887734e-01 0.005 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.892279e-01 0.005 0 0
GPCR downstream signalling R-HSA-388396 9.893494e-01 0.005 0 0
Selenocysteine synthesis R-HSA-2408557 9.900826e-01 0.004 0 0
Viral mRNA Translation R-HSA-192823 9.908696e-01 0.004 0 0
G alpha (i) signalling events R-HSA-418594 9.915769e-01 0.004 0 0
rRNA processing R-HSA-72312 9.923147e-01 0.003 0 0
Arachidonate metabolism R-HSA-2142753 9.927684e-01 0.003 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.934161e-01 0.003 0 0
Antimicrobial peptides R-HSA-6803157 9.937070e-01 0.003 0 0
Sphingolipid metabolism R-HSA-428157 9.941512e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.950903e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.954803e-01 0.002 0 0
tRNA processing R-HSA-72306 9.963882e-01 0.002 0 0
Nucleotide catabolism R-HSA-8956319 9.973615e-01 0.001 0 0
Signaling by GPCR R-HSA-372790 9.978697e-01 0.001 0 0
Integration of energy metabolism R-HSA-163685 9.981827e-01 0.001 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.983223e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.988950e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.990243e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.991048e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.992071e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.992702e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.994138e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.996085e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.996093e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.997038e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.997069e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.997719e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.998431e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998965e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999469e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999664e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999678e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999957e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999979e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999980e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999983e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999990e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999996e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways