MSK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O43318 S439 Sugiyama MAP3K7 TAK1 GNILDVPEIVISGNGQPRRRsIQDLtVtGTEPGQVssRsss
O60343 S588 Sugiyama TBC1D4 AS160 KIAA0603 tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60664 S93 Sugiyama PLIN3 M6PRBP1 TIP47 AAVsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQP
O60841 S178 Sugiyama EIF5B IF2 KIAA0741 NKKWDGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRK
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75534 T582 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR VEYSLSKGKGNKVSAEKVNKtHsVNGItEEADPTIysGKVI
O75676 S196 SIGNOR|EPSD|PSP RPS6KA4 MSK2 VLTDFGLSKEFLTEEKERtFsFCGTIEYMAPEIIRSKTGHG
O75676 S324 Sugiyama RPS6KA4 MSK2 LDWVALAARKIPAPFRPQIRsELDVGNFAEEFTRLEPVysP
O75676 S343 Sugiyama RPS6KA4 MSK2 RsELDVGNFAEEFTRLEPVysPPGsPPPGDPRIFQGYsFVA
O75676 S347 Sugiyama RPS6KA4 MSK2 DVGNFAEEFTRLEPVysPPGsPPPGDPRIFQGYsFVAPsIL
O75676 S396 Sugiyama RPS6KA4 MSK2 TDGLEAPGAGDRPGRAAVARsAMMQDsPFFQQYELDLREPA
O75676 S402 Sugiyama RPS6KA4 MSK2 PGAGDRPGRAAVARsAMMQDsPFFQQYELDLREPALGQGsF
O75676 S421 Sugiyama RPS6KA4 MSK2 DsPFFQQYELDLREPALGQGsFSVCRRCRQRQsGQEFAVKI
O75676 S433 Sugiyama RPS6KA4 MSK2 REPALGQGsFSVCRRCRQRQsGQEFAVKILSRRLEANtQRE
O75676 S502 Sugiyama RPS6KA4 MSK2 VLELLRGGELLEHIRKKRHFsESEAsQILRSLVSAVSFMHE
O75676 S507 Sugiyama RPS6KA4 MSK2 RGGELLEHIRKKRHFsESEAsQILRSLVSAVSFMHEEAGVV
O75676 S678 Sugiyama RPS6KA4 MSK2 DPAKRLKLEGLRGSSWLQDGsARssPPLRtPDVLEssGPAV
O75676 S682 Sugiyama RPS6KA4 MSK2 RLKLEGLRGSSWLQDGsARssPPLRtPDVLEssGPAVRsGL
O75676 S693 Sugiyama RPS6KA4 MSK2 WLQDGsARssPPLRtPDVLEssGPAVRsGLNAtFMAFNRGK
O75676 S694 Sugiyama RPS6KA4 MSK2 LQDGsARssPPLRtPDVLEssGPAVRsGLNAtFMAFNRGKR
O75676 S700 Sugiyama RPS6KA4 MSK2 RssPPLRtPDVLEssGPAVRsGLNAtFMAFNRGKREGFFLK
O75676 S745 Sugiyama RPS6KA4 MSK2 APLAKRRKQKLRsATASRRGsPAPANPGRAPVAsKGAPRRA
O75676 S758 Sugiyama RPS6KA4 MSK2 ATASRRGsPAPANPGRAPVAsKGAPRRANGPLPPS______
O75676 S87 Sugiyama RPS6KA4 MSK2 LRKAALVQRAKTQEHTRTERsVLELVRQAPFLVTLHYAFQT
O75676 T22 Sugiyama RPS6KA4 MSK2 GDEDDDESCAVELRITEANLtGHEEKVSVENFELLKVLGTG
O75676 T450 Sugiyama RPS6KA4 MSK2 QRQsGQEFAVKILSRRLEANtQREVAALRLCQSHPNVVNLH
O75676 T656 Sugiyama RPS6KA4 MSK2 DGEAWQGVSEEAKELVRGLLtVDPAKRLKLEGLRGSSWLQD
O75676 T687 EPSD|Sugiyama RPS6KA4 MSK2 GLRGSSWLQDGsARssPPLRtPDVLEssGPAVRsGLNAtFM
O75676 T705 Sugiyama RPS6KA4 MSK2 LRtPDVLEssGPAVRsGLNAtFMAFNRGKREGFFLKsVENA
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
P01100 S362 SIGNOR FOS G0S7 VFTYPEADSFPSCAAAHRKGsSsNEPSSDSLSsPTLLAL__
P01100 S374 SIGNOR FOS G0S7 CAAAHRKGsSsNEPSSDSLSsPTLLAL______________
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05114 S7 SIGNOR|iPTMNet|EPSD HMGN1 HMG14 ______________MPKRKVssAEGAAKEEPKRRsARLsAK
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05388 S307 Sugiyama RPLP0 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
P05783 S93 Sugiyama KRT18 CYK18 PIG46 GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07900 S399 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08238 S391 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 S497 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0DPH7 T51 Sugiyama TUBA3C TUBA2 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P11142 S329 Sugiyama HSPA8 HSC70 HSP73 HSPA10 LFRGtLDPVEKALRDAKLDKsQIHDIVLVGGstRIPKIQKL
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12270 S2155 Sugiyama TPR PstPtLVVPHRtDGFAEAIHsPQVAGVPRFRFGPPEDMPQT
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13861 S58 Sugiyama PRKAR2A PKR2 PRKAR2 TRLREARAPAsVLPAAtPRQsLGHPPPEPGPDRVADAKGDs
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P15336 T69 Sugiyama ATF2 CREB2 CREBP1 HEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELA
P15336 T71 Sugiyama ATF2 CREB2 CREBP1 MtLKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELAsP
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15880 S190 Sugiyama RPS2 RPS4 WGNKIGKPHTVPCKVTGRCGsVLVRLIPAPRGtGIVsAPVP
P16220 S119 SIGNOR|PSP CREB1 EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16333 S85 Sugiyama NCK1 NCK ASIVKNLKDTLGIGKVKRKPsVPDsAsPADDsFVDPGERLy
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18669 S31 Sugiyama PGAM1 PGAMA CDABP0006 HGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALRDAGyE
P18846 S63 SIGNOR|iPTMNet|EPSD ATF1 DsSDsIGssQKAHGILARRPsYRKILKDLsSEDTRGRKGDG
P18858 S901 Sugiyama LIG1 DKQPEQATTSAQVACLYRKQsQIQNQQGEDsGsDPEDTY__
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20618 Y158 Sugiyama PSMB1 PSC5 IGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLD
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P23588 S311 Sugiyama EIF4B YRGGGDRYEDRYDRRDDRsWssRDDysRDDYRRDDRGPPQR
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P27348 S63 Sugiyama YWHAQ LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P28482 Y187 Sugiyama MAPK1 ERK2 PRKM1 PRKM2 DFGLARVADPDHDHtGFLtEyVAtRWyRAPEIMLNSKGYTK
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30533 S247 Sugiyama LRPAP1 A2MRAP KLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQSA
P30533 Y246 Sugiyama LRPAP1 A2MRAP EKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQS
P31946 S65 Sugiyama YWHAB LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35221 S641 Sugiyama CTNNA1 GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37108 S25 Sugiyama SRP14 EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243 T150 Sugiyama MATR3 KIAA0723 EDKItPENLPQILLQLKRRRtEEGPtLsyGRDGRsAtREPP
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 S648 Sugiyama MKI67 RVSISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLG
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46776 Y108 Sugiyama RPL27A VNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKAKF
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46937 S109 Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P46937 T114 Sugiyama YAP1 YAP65 sFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQL
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P51116 S504 Sugiyama FXR2 FMR1L2 PTGGRGRGPPPAPRPTSRYNsSsISSVLKDPDsNPYSLLDt
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P52948 S623 Sugiyama NUP98 ADAR2 KNLNNsNLFsPVNRDsENLAsPsEyPENGERFsFLSKPVDE
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P54253 S775 PSP ATXN1 ATX1 SCA1 APFLTKIEPSKPAATRKRRWsAPESRKLEKSEDEPPLTLPK
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60484 T382 Sugiyama PTEN MMAC1 TEP1 sTSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQItK
P60484 T383 Sugiyama PTEN MMAC1 TEP1 TSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQItKV
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61081 S175 Sugiyama UBE2M UBC12 NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S64 Sugiyama YWHAG LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S138 Sugiyama RPL8 EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62979 S123 Sugiyama RPS27A UBA80 UBCEP1 LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 S439 Sugiyama TUBA1B SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68363 T51 Sugiyama TUBA1B QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P68431 S11 GPS6|EPSD H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J __________MARtKQtARKstGGKAPRKQLATKAARKsAP
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84243 S11 GPS6 H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B __________MARtKQTARKstGGKAPRKQLATKAARKsAP
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q04206 S276 GPS6|SIGNOR|EPSD|PSP RELA NFKB3 PYADPsLQAPVRVsMQLRRPsDRELsEPMEFQYLPDTDDRH
Q04917 S64 Sugiyama YWHAH YWHA1 LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA
Q06210 T263 Sugiyama GFPT1 GFAT GFPT QGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDASA
Q07866 S524 Sugiyama KLC1 KLC KNS2 QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q12965 T936 Sugiyama MYO1E MYO1C LQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAP
Q13206 S829 Sugiyama DDX10 sEDMENKISDTKKKQGMKKRsNsEVEDVGPTsHNRKKARWD
Q13283 S231 Sugiyama G3BP1 G3BP QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14847 S146 Sugiyama LASP1 MLN50 FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15293 T76 Sugiyama RCN1 RCN FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16695 S11 SIGNOR H3-4 H3FT HIST3H3 __________MARtKQTARKsTGGKAPRKQLATKVARKsAP
Q16695 S29 SIGNOR H3-4 H3FT HIST3H3 RKsTGGKAPRKQLATKVARKsAPATGGVKKPHRyRPGtVAL
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3KQU3 S112 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 KsRGPtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEV
Q3KQU3 S116 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 PtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEVKKAG
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q4G0J3 S300 Sugiyama LARP7 HDCMA18P DRVEAssLPEVRTGKRKRsssEDAEsLAPRSKVKKIIQKDI
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S370 Sugiyama HSP90AB3P HSP90BC KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5SW79 S881 Sugiyama CEP170 FAM68A KAB KIAA0470 sstPssLALtsAsRIRERsEsLDPDssMDTtLILKDTEAVM
Q5T0N5 S488 Sugiyama FNBP1L C1orf39 TOCA1 NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD
Q5TCZ1 S1038 Sugiyama SH3PXD2A FISH KIAA0418 SH3MD1 TKS5 FSTARSAAAEAKGRLAERAAsQGsDsPLLPAQRNsIPVsPV
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6GYQ0 S864 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 AERLRSGNASTMTRRGssPGsLEIPKDLPDILNKQNQMRPI
Q6P6C2 S96 Sugiyama ALKBH5 ABH5 OFOXD1 LQKEEEARKVKSGIRQMRLFsQDECAKIEARIDEVVSRAEK
Q6PEY2 T51 Sugiyama TUBA3E QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6PKG0 S824 Sugiyama LARP1 KIAA0731 LARP VKEGRTLDAKMPRKRKtRHssNPPLEsHVGWVMDSREHRPR
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6VY07 S528 Sugiyama PACS1 KIAA1175 KRSTPLKERQLsKPLsERtNssDsERsPDLGHsTQIPRKVV
Q6ZN18 S206 Sugiyama AEBP2 DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q71DI3 S11 GPS6 H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D __________MARtKQTARKsTGGKAPRKQLATKAARKsAP
Q71U36 S439 Sugiyama TUBA1A TUBA3 SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q71U36 T51 Sugiyama TUBA1A TUBA3 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8N201 S495 Sugiyama INTS1 KIAA1440 UNQ1821/PRO3434 KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NHW5 S307 Sugiyama RPLP0P6 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q92597 S330 Sugiyama NDRG1 CAP43 DRG1 RTP QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92766 S1167 Sugiyama RREB1 FINB AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q96G46 T240 Sugiyama DUS3L KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96RU3 S497 Sugiyama FNBP1 FBP17 KIAA0554 AWLAEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREs
Q9BQE3 T51 Sugiyama TUBA1C TUBA6 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BTC0 S1456 Sugiyama DIDO1 C20orf158 DATF1 KIAA0333 EAKVTVDDLPNRMCADVRRNsVERPAEPVAGAAtPsLVEQQ
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9C0C2 S1616 Sugiyama TNKS1BP1 KIAA1741 TAB182 LSEAADsDAHLFQDSTEPRAsRVPssDEEVVEEPQsRRTRM
Q9C0C2 S1666 Sugiyama TNKS1BP1 KIAA1741 TAB182 NLFPGLsPsALKAKLRPRNRsAEEGELAESKssQKESAVQR
Q9C0C2 S429 Sugiyama TNKS1BP1 KIAA1741 TAB182 EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9C0C2 S920 Sugiyama TNKS1BP1 KIAA1741 TAB182 QDANEQGQDLGKRDHHGRyssQDADEQDWEFQKRDVsLGTy
Q9H1K0 S548 Sugiyama RBSN ZFYVE20 RELEREREQFRVASLHTRTRsLDFREIGPFQLEPSREPRTH
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NVW2 S191 Sugiyama RLIM RNF12 NSQRQVENPRSESTSARPSRsERNstEALTEVPPTRGQRRA
Q9UBP6 S27 Sugiyama METTL1 C12orf1 NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2 S338 Sugiyama NDRG3 SASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDGtQES
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKJ3 S890 Sugiyama GPATCH8 GPATC8 KIAA0553 YSSSSDASSDQSCYSRQRSYsDDSYSDYSDRSRRHSKRSHD
Q9UKV3 T563 Sugiyama ACIN1 ACINUS KIAA0670 TEECLKQPsLEQKEGRRAsHtLLPSHRLKQSADSSSSRSSS
Q9ULL1 S611 Sugiyama PLEKHG1 KIAA1209 GQMESTETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTREL
Q9UNF1 S264 Sugiyama MAGED2 BCG1 sLRsPKARRGKARRRAAKLQssQEPEAPPPRDVALLQGRAN
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7 S137 Sugiyama YBX2 CSDA3 MSY2 EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA
Q9Y4H2 S560 Sugiyama IRS2 YGyMtMDRPLsHCGRSYRRVsGDAAQDLDRGLRKRtYsLtT
Q9Y5L4 S57 Sugiyama TIMM13 TIM13B TIMM13A TIMM13B ELLQRMTDKCFRKCIGKPGGsLDNSEQKCIAMCMDRyMDAW
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 3.001871e-08 7.523 0 0
NRAGE signals death through JNK R-HSA-193648 2.677199e-08 7.572 0 0
G alpha (12/13) signalling events R-HSA-416482 2.681115e-07 6.572 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.503461e-07 6.601 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.833561e-06 5.737 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.929180e-06 5.533 0 0
Chromatin modifying enzymes R-HSA-3247509 9.706643e-06 5.013 0 0
Death Receptor Signaling R-HSA-73887 1.262838e-05 4.899 0 0
Chromatin organization R-HSA-4839726 4.526318e-05 4.344 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.535214e-05 4.257 0 0
Meiotic synapsis R-HSA-1221632 5.677209e-05 4.246 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.149120e-04 3.940 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.289005e-04 3.890 0 0
Cell Cycle Checkpoints R-HSA-69620 1.862901e-04 3.730 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.227861e-04 3.652 0 0
Regulation of TP53 Activity R-HSA-5633007 2.286515e-04 3.641 0 0
Post NMDA receptor activation events R-HSA-438064 2.643135e-04 3.578 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.358072e-04 3.474 0 0
Signaling by Hippo R-HSA-2028269 3.487140e-04 3.458 0 0
Cell Cycle R-HSA-1640170 3.649040e-04 3.438 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.051822e-04 3.392 0 0
Axon guidance R-HSA-422475 4.341622e-04 3.362 1 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.694318e-04 3.328 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.149034e-04 3.211 0 0
Packaging Of Telomere Ends R-HSA-171306 6.794280e-04 3.168 0 0
Rap1 signalling R-HSA-392517 6.766871e-04 3.170 0 0
RET signaling R-HSA-8853659 7.398167e-04 3.131 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 7.998243e-04 3.097 0 0
HATs acetylate histones R-HSA-3214847 8.269070e-04 3.083 0 0
Apoptotic execution phase R-HSA-75153 8.676302e-04 3.062 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 8.967460e-04 3.047 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.084492e-03 2.965 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.065291e-03 2.973 0 0
DARPP-32 events R-HSA-180024 1.116358e-03 2.952 0 0
MTOR signalling R-HSA-165159 1.097117e-03 2.960 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.277163e-03 2.894 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.307878e-03 2.883 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.297930e-03 2.887 0 0
Nervous system development R-HSA-9675108 1.413625e-03 2.850 1 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.416146e-03 2.849 0 0
Mitotic Prophase R-HSA-68875 1.613625e-03 2.792 0 0
Cellular Senescence R-HSA-2559583 1.744714e-03 2.758 0 0
Nucleosome assembly R-HSA-774815 1.912977e-03 2.718 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.912977e-03 2.718 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.122836e-03 2.673 0 0
Calmodulin induced events R-HSA-111933 2.132068e-03 2.671 0 0
CaM pathway R-HSA-111997 2.132068e-03 2.671 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.034807e-03 2.691 0 0
Meiosis R-HSA-1500620 1.965142e-03 2.707 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.189049e-03 2.660 0 0
M Phase R-HSA-68886 2.341330e-03 2.631 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.450064e-03 2.611 0 0
mRNA 3'-end processing R-HSA-72187 2.472962e-03 2.607 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.784746e-03 2.555 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.784746e-03 2.555 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.865423e-03 2.543 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.865423e-03 2.543 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.086368e-03 2.511 0 0
Diseases of programmed cell death R-HSA-9645723 3.224219e-03 2.492 0 0
DNA methylation R-HSA-5334118 3.392799e-03 2.469 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.396004e-03 2.469 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.741835e-03 2.427 0 0
Cell Cycle, Mitotic R-HSA-69278 3.759891e-03 2.425 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.175991e-03 2.379 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.059281e-03 2.392 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.096147e-03 2.388 0 0
DNA Double Strand Break Response R-HSA-5693606 4.137833e-03 2.383 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.427118e-03 2.354 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.457623e-03 2.351 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.661786e-03 2.331 0 0
DAG and IP3 signaling R-HSA-1489509 4.814946e-03 2.317 0 0
Reproduction R-HSA-1474165 5.251846e-03 2.280 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.279739e-03 2.277 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.300080e-03 2.276 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.632298e-03 2.249 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.872789e-03 2.231 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.090769e-03 2.215 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 6.775905e-03 2.169 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.531844e-03 2.185 0 0
PKA activation R-HSA-163615 6.531844e-03 2.185 0 0
PKA activation in glucagon signalling R-HSA-164378 6.531844e-03 2.185 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.773677e-03 2.169 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.773677e-03 2.169 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.259198e-03 2.203 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 6.478293e-03 2.189 0 0
Cleavage of the damaged purine R-HSA-110331 6.813141e-03 2.167 0 0
Ca-dependent events R-HSA-111996 7.286517e-03 2.137 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.286517e-03 2.137 0 0
Depyrimidination R-HSA-73928 7.286517e-03 2.137 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.384652e-03 2.132 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.846150e-03 2.105 0 0
DCC mediated attractive signaling R-HSA-418885 7.914910e-03 2.102 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.044351e-03 2.095 0 0
Depurination R-HSA-73927 8.044351e-03 2.095 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.307358e-03 2.081 0 0
Activation of RAC1 R-HSA-428540 9.305055e-03 2.031 0 0
Estrogen-dependent gene expression R-HSA-9018519 9.553614e-03 2.020 0 0
Netrin-1 signaling R-HSA-373752 9.853324e-03 2.006 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.027126e-02 1.988 0 0
Signaling by ROBO receptors R-HSA-376176 9.942605e-03 2.002 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.009773e-02 1.996 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.009773e-02 1.996 0 0
Neurodegenerative Diseases R-HSA-8863678 1.009773e-02 1.996 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.029621e-02 1.987 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.030309e-02 1.987 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.030309e-02 1.987 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 9.738796e-03 2.011 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 9.139374e-03 2.039 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.102376e-02 1.958 0 0
G2/M Checkpoints R-HSA-69481 1.161134e-02 1.935 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.192210e-02 1.924 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.213185e-02 1.916 0 0
FOXO-mediated transcription R-HSA-9614085 1.270756e-02 1.896 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.310063e-02 1.883 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.226275e-02 1.911 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.244461e-02 1.905 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.393482e-02 1.856 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.406004e-02 1.852 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.539021e-02 1.813 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 1.539021e-02 1.813 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.433939e-02 1.843 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.449049e-02 1.839 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.444625e-02 1.840 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.453555e-02 1.838 0 0
TRP channels R-HSA-3295583 1.475710e-02 1.831 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.530924e-02 1.815 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.539021e-02 1.813 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.580816e-02 1.801 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.580816e-02 1.801 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.605462e-02 1.794 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.742139e-02 1.759 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.769495e-02 1.752 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.769495e-02 1.752 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.757993e-02 1.755 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.624996e-02 1.789 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.667063e-02 1.778 0 0
Kinesins R-HSA-983189 1.658855e-02 1.780 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.760571e-02 1.754 0 0
Specification of primordial germ cells R-HSA-9827857 1.644984e-02 1.784 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.658855e-02 1.780 0 0
PLC beta mediated events R-HSA-112043 1.860199e-02 1.730 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.870212e-02 1.728 0 0
HDACs deacetylate histones R-HSA-3214815 1.905407e-02 1.720 0 0
mTORC1-mediated signalling R-HSA-166208 1.914899e-02 1.718 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.931917e-02 1.714 0 0
Opioid Signalling R-HSA-111885 1.981215e-02 1.703 0 0
CREB phosphorylation R-HSA-199920 2.252453e-02 1.647 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.216625e-02 1.654 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.141016e-02 1.669 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.154646e-02 1.667 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.154646e-02 1.667 0 0
Heme signaling R-HSA-9707616 2.079641e-02 1.682 0 0
RAF activation R-HSA-5673000 2.519350e-02 1.599 0 0
mRNA Splicing R-HSA-72172 2.678920e-02 1.572 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.536432e-02 1.596 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.616863e-02 1.582 0 0
Homology Directed Repair R-HSA-5693538 2.611620e-02 1.583 0 0
RNA Polymerase II Transcription R-HSA-73857 2.589091e-02 1.587 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.616863e-02 1.582 0 0
Meiotic recombination R-HSA-912446 2.465748e-02 1.608 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.727099e-02 1.564 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.784394e-02 1.555 0 0
Signaling by VEGF R-HSA-194138 2.833471e-02 1.548 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.853431e-02 1.545 0 0
Interleukin-37 signaling R-HSA-9008059 2.853431e-02 1.545 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.855808e-02 1.544 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.004355e-02 1.522 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.004565e-02 1.522 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 3.453570e-02 1.462 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 3.453570e-02 1.462 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.138149e-02 1.503 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.342255e-02 1.476 0 0
ESR-mediated signaling R-HSA-8939211 3.304463e-02 1.481 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.214126e-02 1.493 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.453570e-02 1.462 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.453570e-02 1.462 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.302345e-02 1.481 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.444891e-02 1.463 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.453570e-02 1.462 0 0
Dopamine receptors R-HSA-390651 3.453570e-02 1.462 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.420748e-02 1.466 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.418372e-02 1.466 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.236103e-02 1.490 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.450899e-02 1.462 0 0
G-protein mediated events R-HSA-112040 3.480391e-02 1.458 0 0
Co-stimulation by CD28 R-HSA-389356 3.582979e-02 1.446 0 0
NGF-stimulated transcription R-HSA-9031628 3.582979e-02 1.446 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.755395e-02 1.425 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.774377e-02 1.423 0 0
Signaling by NTRKs R-HSA-166520 3.926547e-02 1.406 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.939417e-02 1.405 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.943392e-02 1.404 0 0
Cell junction organization R-HSA-446728 4.004264e-02 1.397 0 0
Gene expression (Transcription) R-HSA-74160 4.061579e-02 1.391 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.201675e-02 1.377 0 0
Type I hemidesmosome assembly R-HSA-446107 4.201675e-02 1.377 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.206855e-02 1.376 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 4.908492e-02 1.309 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 4.908492e-02 1.309 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.354635e-02 1.361 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.354635e-02 1.361 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.351125e-02 1.361 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.817974e-02 1.317 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.333533e-02 1.363 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.351125e-02 1.361 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.690398e-02 1.329 0 0
Membrane Trafficking R-HSA-199991 4.409424e-02 1.356 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.690398e-02 1.329 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.817974e-02 1.317 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.949108e-02 1.305 0 0
HIV elongation arrest and recovery R-HSA-167287 5.013671e-02 1.300 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.013671e-02 1.300 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.040943e-02 1.297 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.040943e-02 1.297 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.040943e-02 1.297 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.040943e-02 1.297 0 0
NrCAM interactions R-HSA-447038 5.040943e-02 1.297 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.180555e-02 1.286 0 0
HIV Transcription Elongation R-HSA-167169 5.405909e-02 1.267 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.405909e-02 1.267 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.405909e-02 1.267 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.444384e-02 1.264 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.444384e-02 1.264 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 5.459256e-02 1.263 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.459256e-02 1.263 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.464018e-02 1.262 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.530655e-02 1.257 0 0
Ephrin signaling R-HSA-3928664 5.633017e-02 1.249 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.633017e-02 1.249 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.039327e-02 1.219 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.753840e-02 1.240 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.753840e-02 1.240 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.753840e-02 1.240 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.666997e-02 1.247 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.769345e-02 1.239 0 0
Signaling by RAS mutants R-HSA-6802949 5.753840e-02 1.240 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.039327e-02 1.219 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.475968e-02 1.189 0 0
Regulation of KIT signaling R-HSA-1433559 6.305854e-02 1.200 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.616123e-02 1.251 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.243383e-02 1.205 0 0
Rab regulation of trafficking R-HSA-9007101 6.382810e-02 1.195 0 0
FLT3 Signaling R-HSA-9607240 6.039327e-02 1.219 0 0
Cell-Cell communication R-HSA-1500931 5.589397e-02 1.253 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.531141e-02 1.185 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.645392e-02 1.177 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.719025e-02 1.173 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.863831e-02 1.163 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.863831e-02 1.163 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.920584e-02 1.160 0 0
Glycolysis R-HSA-70171 6.971166e-02 1.157 0 0
Mitotic Anaphase R-HSA-68882 7.121638e-02 1.147 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.122039e-02 1.147 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.122039e-02 1.147 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.122039e-02 1.147 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 7.433290e-02 1.129 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.446082e-02 1.128 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.540578e-02 1.123 0 0
Long-term potentiation R-HSA-9620244 7.597218e-02 1.119 0 0
HDMs demethylate histones R-HSA-3214842 7.597218e-02 1.119 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.867628e-02 1.104 0 0
Semaphorin interactions R-HSA-373755 8.023582e-02 1.096 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 8.092813e-02 1.092 0 0
Regulation of cortical dendrite branching R-HSA-8985801 8.092813e-02 1.092 0 0
Potassium transport channels R-HSA-1296067 8.092813e-02 1.092 0 0
Regulation of TP53 Expression R-HSA-6804754 8.092813e-02 1.092 0 0
Generic Transcription Pathway R-HSA-212436 8.201670e-02 1.086 0 0
Defective pyroptosis R-HSA-9710421 8.219413e-02 1.085 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.321982e-02 1.080 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.359557e-02 1.078 0 0
Apoptosis R-HSA-109581 8.503940e-02 1.070 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.732602e-02 1.059 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 9.068006e-02 1.042 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.013556e-01 0.994 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 9.243112e-02 1.034 0 0
Metabolism of non-coding RNA R-HSA-194441 1.013239e-01 0.994 0 0
snRNP Assembly R-HSA-191859 1.013239e-01 0.994 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.014499e-01 0.994 0 0
Prolonged ERK activation events R-HSA-169893 8.896269e-02 1.051 0 0
EPH-Ephrin signaling R-HSA-2682334 9.839342e-02 1.007 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.020712e-01 0.991 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.040648e-02 1.044 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.004590e-01 0.998 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 9.068006e-02 1.042 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.727229e-02 1.012 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.027780e-01 0.988 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 9.068006e-02 1.042 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.013556e-01 0.994 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.051293e-01 0.978 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.051293e-01 0.978 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.100391e-02 1.041 0 0
Generation of second messenger molecules R-HSA-202433 1.062285e-01 0.974 0 0
Signaling by ERBB4 R-HSA-1236394 1.084973e-01 0.965 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.095038e-01 0.961 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.137423e-01 0.944 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.145398e-01 0.941 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.145398e-01 0.941 0 0
SOS-mediated signalling R-HSA-112412 1.145398e-01 0.941 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.145398e-01 0.941 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.145398e-01 0.941 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 1.145398e-01 0.941 0 0
Regulation of PTEN localization R-HSA-8948747 1.145398e-01 0.941 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.148932e-01 0.940 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.148932e-01 0.940 0 0
Programmed Cell Death R-HSA-5357801 1.172485e-01 0.931 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.173660e-01 0.930 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.173660e-01 0.930 0 0
Aquaporin-mediated transport R-HSA-445717 1.180582e-01 0.928 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.211158e-01 0.917 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.214870e-01 0.915 0 0
Chromosome Maintenance R-HSA-73886 1.214870e-01 0.915 0 0
Signaling by Erythropoietin R-HSA-9006335 1.215178e-01 0.915 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.215178e-01 0.915 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.090377e-01 0.680 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.090377e-01 0.680 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.090377e-01 0.680 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.090377e-01 0.680 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.090377e-01 0.680 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.090377e-01 0.680 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.090377e-01 0.680 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.090377e-01 0.680 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.090377e-01 0.680 0 0
Regulation of gap junction activity R-HSA-191650 1.569933e-01 0.804 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 1.569933e-01 0.804 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.569933e-01 0.804 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.569933e-01 0.804 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 2.965570e-01 0.528 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.965570e-01 0.528 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.965570e-01 0.528 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.965570e-01 0.528 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.965570e-01 0.528 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.965570e-01 0.528 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.965570e-01 0.528 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.965570e-01 0.528 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.965570e-01 0.528 0 0
Intestinal infectious diseases R-HSA-8942233 2.965570e-01 0.528 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.965570e-01 0.528 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.965570e-01 0.528 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 2.965570e-01 0.528 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.965570e-01 0.528 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.986591e-01 0.702 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.986591e-01 0.702 0 0
IRS activation R-HSA-74713 1.986591e-01 0.702 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.986591e-01 0.702 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.986591e-01 0.702 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.404660e-01 0.852 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.404660e-01 0.852 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.404660e-01 0.852 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.404660e-01 0.852 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.681290e-01 0.774 0 0
ARMS-mediated activation R-HSA-170984 1.681290e-01 0.774 0 0
Calcineurin activates NFAT R-HSA-2025928 1.681290e-01 0.774 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.414280e-01 0.617 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.414280e-01 0.617 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.414280e-01 0.617 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.414280e-01 0.617 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.414280e-01 0.617 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.743969e-01 0.427 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.743969e-01 0.427 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.743969e-01 0.427 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.743969e-01 0.427 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.743969e-01 0.427 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.743969e-01 0.427 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.743969e-01 0.427 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.743969e-01 0.427 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.743969e-01 0.427 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.743969e-01 0.427 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.743969e-01 0.427 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.743969e-01 0.427 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.743969e-01 0.427 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.743969e-01 0.427 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.743969e-01 0.427 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.743969e-01 0.427 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 3.743969e-01 0.427 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.743969e-01 0.427 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.743969e-01 0.427 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.743969e-01 0.427 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.743969e-01 0.427 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.415503e-01 0.849 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.845463e-01 0.546 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.845463e-01 0.546 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.364541e-01 0.865 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.273616e-01 0.643 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.273616e-01 0.643 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.273616e-01 0.643 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.860229e-01 0.730 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.860229e-01 0.730 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.860229e-01 0.730 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.543542e-01 0.811 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.543542e-01 0.811 0 0
Deadenylation of mRNA R-HSA-429947 1.445048e-01 0.840 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.731641e-01 0.762 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.731641e-01 0.762 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.731641e-01 0.762 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.731641e-01 0.762 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.731641e-01 0.762 0 0
Differentiation of T cells R-HSA-9945266 2.097595e-01 0.678 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 2.097595e-01 0.678 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.097595e-01 0.678 0 0
Phosphorylation of the APC/C R-HSA-176412 2.097595e-01 0.678 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.583110e-01 0.588 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.583110e-01 0.588 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.274135e-01 0.485 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.274135e-01 0.485 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.274135e-01 0.485 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.274135e-01 0.485 0 0
Netrin mediated repulsion signals R-HSA-418886 3.274135e-01 0.485 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.274135e-01 0.485 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.274135e-01 0.485 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.274135e-01 0.485 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.436275e-01 0.353 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.436275e-01 0.353 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.436275e-01 0.353 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.436275e-01 0.353 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.436275e-01 0.353 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.436275e-01 0.353 0 0
Defective ABCA3 causes SMDP3 R-HSA-5688399 4.436275e-01 0.353 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.436275e-01 0.353 0 0
MET activates PTPN11 R-HSA-8865999 4.436275e-01 0.353 0 0
Invadopodia formation R-HSA-8941237 4.436275e-01 0.353 0 0
Defective ABCA3 causes SMDP3 R-HSA-5683678 4.436275e-01 0.353 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.436275e-01 0.353 0 0
Tight junction interactions R-HSA-420029 1.604937e-01 0.795 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.927986e-01 0.715 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.342899e-01 0.630 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.342899e-01 0.630 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.897676e-01 0.538 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.897676e-01 0.538 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.897676e-01 0.538 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.897676e-01 0.538 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.897676e-01 0.538 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.897676e-01 0.538 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.897676e-01 0.538 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.897676e-01 0.538 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.945838e-01 0.711 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.945838e-01 0.711 0 0
RSK activation R-HSA-444257 3.695577e-01 0.432 0 0
Regulation by c-FLIP R-HSA-3371378 3.695577e-01 0.432 0 0
Dimerization of procaspase-8 R-HSA-69416 3.695577e-01 0.432 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.695577e-01 0.432 0 0
Integrin signaling R-HSA-354192 1.781301e-01 0.749 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.125710e-01 0.672 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.125710e-01 0.672 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.557386e-01 0.592 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.311050e-01 0.636 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.099693e-01 0.678 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.501223e-01 0.602 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.111224e-01 0.507 0 0
CASP8 activity is inhibited R-HSA-5218900 4.106141e-01 0.387 0 0
ALK mutants bind TKIs R-HSA-9700645 4.106141e-01 0.387 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.052004e-01 0.297 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.052004e-01 0.297 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.052004e-01 0.297 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.052004e-01 0.297 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.052004e-01 0.297 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 5.052004e-01 0.297 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.695580e-01 0.569 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.695580e-01 0.569 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.001229e-01 0.523 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.370466e-01 0.625 0 0
Transcription of the HIV genome R-HSA-167172 1.879384e-01 0.726 0 0
Erythropoietin activates RAS R-HSA-9027284 3.847292e-01 0.415 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.847292e-01 0.415 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.847292e-01 0.415 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.847292e-01 0.415 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.227625e-01 0.491 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.992432e-01 0.701 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.171701e-01 0.663 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.171701e-01 0.663 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.108435e-01 0.676 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.094236e-01 0.509 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.503076e-01 0.346 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.503076e-01 0.346 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.503076e-01 0.346 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.455804e-01 0.461 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 4.158894e-01 0.381 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.158894e-01 0.381 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.472713e-01 0.607 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.501834e-01 0.456 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.501834e-01 0.456 0 0
Centrosome maturation R-HSA-380287 2.727538e-01 0.564 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.707415e-01 0.431 0 0
Late endosomal microautophagy R-HSA-9615710 3.914128e-01 0.407 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.465196e-01 0.350 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.884372e-01 0.311 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.884372e-01 0.311 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.884372e-01 0.311 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.884372e-01 0.311 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 5.599624e-01 0.252 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.599624e-01 0.252 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.599624e-01 0.252 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.599624e-01 0.252 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.599624e-01 0.252 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.599624e-01 0.252 0 0
Defective F9 activation R-HSA-9673221 5.599624e-01 0.252 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.599624e-01 0.252 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.599624e-01 0.252 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.582373e-01 0.588 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.764854e-01 0.322 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.764854e-01 0.322 0 0
Trafficking of AMPA receptors R-HSA-399719 4.369857e-01 0.360 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.248630e-01 0.280 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.248630e-01 0.280 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.239590e-01 0.373 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.056742e-01 0.296 0 0
GAB1 signalosome R-HSA-180292 5.056742e-01 0.296 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.056742e-01 0.296 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.036642e-01 0.298 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 5.339938e-01 0.272 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.339938e-01 0.272 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.339938e-01 0.272 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.594952e-01 0.252 0 0
Cam-PDE 1 activation R-HSA-111957 6.086664e-01 0.216 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.086664e-01 0.216 0 0
PDE3B signalling R-HSA-165160 6.086664e-01 0.216 0 0
PKB-mediated events R-HSA-109703 6.086664e-01 0.216 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.086664e-01 0.216 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.086664e-01 0.216 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.086664e-01 0.216 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.086664e-01 0.216 0 0
Signaling by MAPK mutants R-HSA-9652817 6.086664e-01 0.216 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.086664e-01 0.216 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.652774e-01 0.332 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.127357e-01 0.290 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.127357e-01 0.290 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.127357e-01 0.290 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.252117e-01 0.280 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.866544e-01 0.313 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.866544e-01 0.313 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 5.613704e-01 0.251 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.613704e-01 0.251 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.204988e-01 0.284 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.640606e-01 0.249 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.640606e-01 0.249 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.922845e-01 0.227 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.922845e-01 0.227 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.557349e-01 0.255 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.598418e-01 0.252 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.877470e-01 0.231 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.867286e-01 0.232 0 0
Voltage gated Potassium channels R-HSA-1296072 5.871824e-01 0.231 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.997000e-01 0.222 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.062951e-01 0.217 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.927346e-01 0.307 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.392306e-01 0.856 0 0
RUNX2 regulates bone development R-HSA-8941326 3.913384e-01 0.407 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.324223e-01 0.364 0 0
Mitotic Prometaphase R-HSA-68877 1.287416e-01 0.890 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.640606e-01 0.249 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.094236e-01 0.509 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.414557e-01 0.355 0 0
Specification of the neural plate border R-HSA-9834899 1.543542e-01 0.811 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.111027e-01 0.507 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.364541e-01 0.865 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.857861e-01 0.544 0 0
Formation of definitive endoderm R-HSA-9823730 5.613704e-01 0.251 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.302537e-01 0.885 0 0
MET promotes cell motility R-HSA-8875878 2.790343e-01 0.554 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.943482e-01 0.531 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.613704e-01 0.251 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.381743e-01 0.269 0 0
Telomere Extension By Telomerase R-HSA-171319 5.640606e-01 0.249 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.851194e-01 0.545 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.342899e-01 0.630 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.930409e-01 0.714 0 0
IRS-mediated signalling R-HSA-112399 3.545965e-01 0.450 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.594952e-01 0.252 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.867286e-01 0.232 0 0
Telomere Maintenance R-HSA-157579 2.066840e-01 0.685 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.364541e-01 0.865 0 0
Hedgehog 'off' state R-HSA-5610787 1.647852e-01 0.783 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.396652e-01 0.469 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.753027e-01 0.756 0 0
Polo-like kinase mediated events R-HSA-156711 1.364541e-01 0.865 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.373306e-01 0.472 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.344037e-01 0.872 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.729953e-01 0.242 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.580138e-01 0.801 0 0
Frs2-mediated activation R-HSA-170968 1.415503e-01 0.849 0 0
p75NTR signals via NF-kB R-HSA-193639 1.860229e-01 0.730 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.937878e-01 0.713 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.868971e-01 0.231 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.769278e-01 0.424 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.681290e-01 0.774 0 0
MAP2K and MAPK activation R-HSA-5674135 1.272584e-01 0.895 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.781301e-01 0.749 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.214736e-01 0.493 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.503076e-01 0.346 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.503076e-01 0.346 0 0
PI3K Cascade R-HSA-109704 3.714938e-01 0.430 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.248630e-01 0.280 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.127357e-01 0.290 0 0
Signaling by FGFR2 R-HSA-5654738 5.815566e-01 0.235 0 0
Circadian clock R-HSA-9909396 4.700126e-01 0.328 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 1.604937e-01 0.795 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 1.681290e-01 0.774 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 1.972003e-01 0.705 0 0
Regulation of CDH11 function R-HSA-9762292 1.972003e-01 0.705 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.274135e-01 0.485 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.594601e-01 0.586 0 0
Nuclear RNA decay R-HSA-9930044 1.781301e-01 0.749 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.893469e-01 0.539 0 0
Formation of apoptosome R-HSA-111458 4.503076e-01 0.346 0 0
PI3K/AKT activation R-HSA-198203 4.503076e-01 0.346 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.653171e-01 0.576 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.501834e-01 0.456 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.170797e-01 0.286 0 0
Myogenesis R-HSA-525793 5.167689e-01 0.287 0 0
Signaling by FGFR4 R-HSA-5654743 3.904002e-01 0.408 0 0
IGF1R signaling cascade R-HSA-2428924 3.393006e-01 0.469 0 0
Insulin receptor signalling cascade R-HSA-74751 4.689955e-01 0.329 0 0
TNF signaling R-HSA-75893 3.384043e-01 0.471 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.569933e-01 0.804 0 0
Sodium/Proton exchangers R-HSA-425986 1.404660e-01 0.852 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.681290e-01 0.774 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.414280e-01 0.617 0 0
NF-kB is activated and signals survival R-HSA-209560 2.583110e-01 0.588 0 0
Adrenoceptors R-HSA-390696 3.695577e-01 0.432 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.695577e-01 0.432 0 0
Unwinding of DNA R-HSA-176974 4.106141e-01 0.387 0 0
Separation of Sister Chromatids R-HSA-2467813 1.804762e-01 0.744 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.599624e-01 0.252 0 0
TGFBR3 expression R-HSA-9839394 4.922435e-01 0.308 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.594952e-01 0.252 0 0
Formation of axial mesoderm R-HSA-9796292 5.922845e-01 0.227 0 0
Signaling by FGFR3 R-HSA-5654741 4.280836e-01 0.368 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.385440e-01 0.858 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.936429e-01 0.226 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.974529e-01 0.303 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.025810e-01 0.519 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.227625e-01 0.491 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.164627e-01 0.287 0 0
Signal attenuation R-HSA-74749 1.972003e-01 0.705 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.272584e-01 0.895 0 0
RNA Polymerase I Transcription R-HSA-73864 2.158884e-01 0.666 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.707415e-01 0.431 0 0
Regulation of signaling by CBL R-HSA-912631 5.339938e-01 0.272 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.594952e-01 0.252 0 0
TCR signaling R-HSA-202403 2.703522e-01 0.568 0 0
Ion homeostasis R-HSA-5578775 2.236737e-01 0.650 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.227625e-01 0.491 0 0
DAP12 signaling R-HSA-2424491 4.142684e-01 0.383 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.937980e-01 0.713 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.375514e-01 0.862 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.324223e-01 0.364 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.064680e-01 0.391 0 0
Signalling to ERKs R-HSA-187687 2.266310e-01 0.645 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.545576e-01 0.450 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.550382e-01 0.593 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.618622e-01 0.335 0 0
Interleukin-1 signaling R-HSA-9020702 5.517026e-01 0.258 0 0
DNA Damage Bypass R-HSA-73893 5.022558e-01 0.299 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.727685e-01 0.242 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.970220e-01 0.705 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.618622e-01 0.335 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.414280e-01 0.617 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.753027e-01 0.756 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.111224e-01 0.507 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.531966e-01 0.452 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.503076e-01 0.346 0 0
Formation of the posterior neural plate R-HSA-9832991 4.884372e-01 0.311 0 0
Activation of AKT2 R-HSA-165158 5.599624e-01 0.252 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.599624e-01 0.252 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.142684e-01 0.383 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.142684e-01 0.383 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.764854e-01 0.322 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.817425e-01 0.317 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.567353e-01 0.340 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.135718e-01 0.289 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.506388e-01 0.259 0 0
Developmental Biology R-HSA-1266738 1.666142e-01 0.778 1 0
DNA Replication Pre-Initiation R-HSA-69002 1.855817e-01 0.731 0 0
Signaling by WNT R-HSA-195721 2.384992e-01 0.623 0 0
Integration of energy metabolism R-HSA-163685 2.636084e-01 0.579 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.654697e-01 0.332 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.272584e-01 0.895 0 0
Triglyceride catabolism R-HSA-163560 3.913384e-01 0.407 0 0
Signaling by Hedgehog R-HSA-5358351 3.641351e-01 0.439 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.297235e-01 0.482 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.036642e-01 0.298 0 0
G alpha (s) signalling events R-HSA-418555 4.671863e-01 0.331 0 0
Signaling by SCF-KIT R-HSA-1433557 2.529813e-01 0.597 0 0
Cilium Assembly R-HSA-5617833 5.683551e-01 0.245 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.384143e-01 0.859 0 0
Signaling by FGFR in disease R-HSA-1226099 3.686806e-01 0.433 0 0
Neurexins and neuroligins R-HSA-6794361 1.726656e-01 0.763 0 0
Glycogen metabolism R-HSA-8982491 3.155059e-01 0.501 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.311050e-01 0.636 0 0
Signaling by WNT in cancer R-HSA-4791275 4.594976e-01 0.338 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.769278e-01 0.424 0 0
Signaling by EGFR R-HSA-177929 2.236737e-01 0.650 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.407258e-01 0.267 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.972003e-01 0.705 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.626017e-01 0.335 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.556668e-01 0.255 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.888588e-01 0.724 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.569933e-01 0.804 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.860229e-01 0.730 0 0
GPER1 signaling R-HSA-9634597 2.159939e-01 0.666 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.094236e-01 0.509 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.167689e-01 0.287 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.086664e-01 0.216 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.127824e-01 0.290 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.924643e-01 0.406 0 0
MAP kinase activation R-HSA-450294 5.598418e-01 0.252 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.127824e-01 0.290 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.127824e-01 0.290 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.922435e-01 0.308 0 0
G2/M Transition R-HSA-69275 2.978096e-01 0.526 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.269832e-01 0.896 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.522690e-01 0.258 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.583110e-01 0.588 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.930036e-01 0.307 0 0
ERK/MAPK targets R-HSA-198753 5.877470e-01 0.231 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.493880e-01 0.347 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.149636e-01 0.502 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.389285e-01 0.857 0 0
Co-inhibition by PD-1 R-HSA-389948 4.227257e-01 0.374 0 0
Autophagy R-HSA-9612973 1.297175e-01 0.887 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.433145e-01 0.265 0 0
Vesicle-mediated transport R-HSA-5653656 6.050285e-01 0.218 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.355149e-01 0.271 0 0
Cardiac conduction R-HSA-5576891 3.662278e-01 0.436 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.527383e-01 0.344 0 0
Metabolism of RNA R-HSA-8953854 4.075545e-01 0.390 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.672119e-01 0.330 0 0
Triglyceride metabolism R-HSA-8979227 5.269369e-01 0.278 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.037762e-01 0.219 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.898502e-01 0.409 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.865267e-01 0.729 0 0
Transmission across Chemical Synapses R-HSA-112315 4.717641e-01 0.326 0 0
DNA Repair R-HSA-73894 4.336411e-01 0.363 0 0
Ub-specific processing proteases R-HSA-5689880 1.958745e-01 0.708 0 0
Interleukin-1 family signaling R-HSA-446652 3.500531e-01 0.456 0 0
Adaptive Immune System R-HSA-1280218 5.536830e-01 0.257 0 0
G0 and Early G1 R-HSA-1538133 4.594976e-01 0.338 0 0
Neuronal System R-HSA-112316 3.292799e-01 0.482 0 0
DNA Replication R-HSA-69306 5.345811e-01 0.272 0 0
MTF1 activates gene expression R-HSA-5660489 1.569933e-01 0.804 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.404660e-01 0.852 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.404660e-01 0.852 0 0
Interleukin-33 signaling R-HSA-9014843 3.743969e-01 0.427 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.097595e-01 0.678 0 0
MET interacts with TNS proteins R-HSA-8875513 4.436275e-01 0.353 0 0
Signaling by LTK R-HSA-9842663 2.897676e-01 0.538 0 0
Co-stimulation by ICOS R-HSA-9927354 3.695577e-01 0.432 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.851194e-01 0.545 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.915463e-01 0.718 0 0
cGMP effects R-HSA-418457 3.531966e-01 0.452 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.106141e-01 0.387 0 0
Cristae formation R-HSA-8949613 3.455804e-01 0.461 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.684911e-01 0.434 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.914128e-01 0.407 0 0
Disorders of Developmental Biology R-HSA-9675151 4.465196e-01 0.350 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.465196e-01 0.350 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.884372e-01 0.311 0 0
Signaling by APC mutants R-HSA-4839744 4.884372e-01 0.311 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.599624e-01 0.252 0 0
Reelin signalling pathway R-HSA-8866376 5.599624e-01 0.252 0 0
Suppression of autophagy R-HSA-9636569 5.599624e-01 0.252 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.119168e-01 0.385 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.387661e-01 0.470 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.248630e-01 0.280 0 0
Signaling by AXIN mutants R-HSA-4839735 5.248630e-01 0.280 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.086664e-01 0.216 0 0
Formation of the Editosome R-HSA-75094 6.086664e-01 0.216 0 0
Synthesis of PS R-HSA-1483101 6.086664e-01 0.216 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.086664e-01 0.216 0 0
Phosphorylation of Emi1 R-HSA-176417 6.086664e-01 0.216 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.252117e-01 0.280 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.922845e-01 0.227 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.922845e-01 0.227 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.922845e-01 0.227 0 0
Platelet calcium homeostasis R-HSA-418360 5.867286e-01 0.232 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.867286e-01 0.232 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.883620e-01 0.230 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.263977e-01 0.645 0 0
Macroautophagy R-HSA-1632852 2.373698e-01 0.625 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.463397e-01 0.263 0 0
Mitochondrial biogenesis R-HSA-1592230 3.704708e-01 0.431 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.531966e-01 0.452 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.817425e-01 0.317 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.921726e-01 0.716 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.340570e-01 0.476 0 0
FLT3 signaling in disease R-HSA-9682385 5.670083e-01 0.246 0 0
MAPK family signaling cascades R-HSA-5683057 1.259738e-01 0.900 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.056365e-01 0.296 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.817425e-01 0.317 0 0
HIV Life Cycle R-HSA-162587 4.003610e-01 0.398 0 0
Cellular response to heat stress R-HSA-3371556 5.164627e-01 0.287 0 0
Selective autophagy R-HSA-9663891 4.652774e-01 0.332 0 0
Cardiogenesis R-HSA-9733709 1.781301e-01 0.749 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.817425e-01 0.317 0 0
Interleukin-2 family signaling R-HSA-451927 4.730123e-01 0.325 0 0
GPVI-mediated activation cascade R-HSA-114604 5.670083e-01 0.246 0 0
Downstream signal transduction R-HSA-186763 2.695580e-01 0.569 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.131679e-01 0.671 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.695577e-01 0.432 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.503076e-01 0.346 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.465196e-01 0.350 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.760495e-01 0.322 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 5.594952e-01 0.252 0 0
TBC/RABGAPs R-HSA-8854214 5.512735e-01 0.259 0 0
tRNA processing in the nucleus R-HSA-6784531 5.759207e-01 0.240 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.867286e-01 0.232 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 5.867286e-01 0.232 0 0
HIV Infection R-HSA-162906 5.967655e-01 0.224 0 0
Cell-cell junction organization R-HSA-421270 2.473415e-01 0.607 0 0
Regulation of insulin secretion R-HSA-422356 5.127824e-01 0.290 0 0
Adherens junctions interactions R-HSA-418990 3.698677e-01 0.432 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.385440e-01 0.858 0 0
Cellular responses to stimuli R-HSA-8953897 5.023129e-01 0.299 0 0
Deubiquitination R-HSA-5688426 5.412432e-01 0.267 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.681290e-01 0.774 0 0
Interleukin-1 processing R-HSA-448706 1.681290e-01 0.774 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.414280e-01 0.617 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.106141e-01 0.387 0 0
Protein hydroxylation R-HSA-9629569 3.373306e-01 0.472 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.847292e-01 0.415 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.297235e-01 0.482 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.159284e-01 0.381 0 0
Disorders of Nervous System Development R-HSA-9697154 5.594952e-01 0.252 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.594952e-01 0.252 0 0
Pervasive developmental disorders R-HSA-9005895 5.594952e-01 0.252 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.086664e-01 0.216 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.086664e-01 0.216 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.086664e-01 0.216 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.288942e-01 0.277 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.945838e-01 0.711 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.772605e-01 0.751 0 0
PI Metabolism R-HSA-1483255 1.821544e-01 0.740 0 0
Signaling by TGFBR3 R-HSA-9839373 6.062951e-01 0.217 0 0
Kidney development R-HSA-9830369 1.769423e-01 0.752 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.108435e-01 0.676 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.106141e-01 0.387 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.833040e-01 0.416 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.364541e-01 0.865 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.847292e-01 0.415 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.022558e-01 0.299 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.022558e-01 0.299 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.972003e-01 0.705 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.781301e-01 0.749 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.030302e-01 0.692 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.965570e-01 0.528 0 0
DSCAM interactions R-HSA-376172 3.743969e-01 0.427 0 0
Tandem pore domain potassium channels R-HSA-1296346 1.972003e-01 0.705 0 0
Synthesis of PI R-HSA-1483226 2.273616e-01 0.643 0 0
Alpha-defensins R-HSA-1462054 3.695577e-01 0.432 0 0
The NLRP3 inflammasome R-HSA-844456 3.111224e-01 0.507 0 0
Sensory perception of sour taste R-HSA-9729555 5.052004e-01 0.297 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.158894e-01 0.381 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.898502e-01 0.409 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.465196e-01 0.350 0 0
PTK6 Down-Regulation R-HSA-8849472 5.599624e-01 0.252 0 0
Interleukin-36 pathway R-HSA-9014826 5.599624e-01 0.252 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.086664e-01 0.216 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.435070e-01 0.265 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.877470e-01 0.231 0 0
Formation of the nephric duct R-HSA-9830364 3.001229e-01 0.523 0 0
Stimuli-sensing channels R-HSA-2672351 2.494889e-01 0.603 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.120093e-01 0.385 0 0
Sensory processing of sound R-HSA-9659379 5.672683e-01 0.246 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.681290e-01 0.774 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.922845e-01 0.227 0 0
Nephron development R-HSA-9831926 1.364541e-01 0.865 0 0
Nuclear import of Rev protein R-HSA-180746 3.501834e-01 0.456 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.393034e-01 0.621 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.328029e-01 0.273 0 0
Signaling by ALK in cancer R-HSA-9700206 2.393034e-01 0.621 0 0
Formation of the anterior neural plate R-HSA-9823739 3.847292e-01 0.415 0 0
Syndecan interactions R-HSA-3000170 4.417462e-01 0.355 0 0
Diseases of DNA repair R-HSA-9675135 6.062951e-01 0.217 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.072360e-01 0.217 0 0
Signaling by Interleukins R-HSA-449147 5.971236e-01 0.224 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.817425e-01 0.317 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.414280e-01 0.617 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.743969e-01 0.427 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.274135e-01 0.485 0 0
Protein ubiquitination R-HSA-8852135 2.727538e-01 0.564 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.730123e-01 0.325 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.730123e-01 0.325 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.930036e-01 0.307 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.086664e-01 0.216 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.922845e-01 0.227 0 0
Amyloid fiber formation R-HSA-977225 1.686747e-01 0.773 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.227625e-01 0.491 0 0
Interleukin-7 signaling R-HSA-1266695 4.922435e-01 0.308 0 0
Regulation of beta-cell development R-HSA-186712 5.269369e-01 0.278 0 0
Glucose metabolism R-HSA-70326 1.448447e-01 0.839 0 0
Maturation of nucleoprotein R-HSA-9683610 3.214736e-01 0.493 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.531966e-01 0.452 0 0
Maturation of nucleoprotein R-HSA-9694631 3.111224e-01 0.507 0 0
Inflammasomes R-HSA-622312 5.640606e-01 0.249 0 0
Activation of BH3-only proteins R-HSA-114452 4.142684e-01 0.383 0 0
Lipophagy R-HSA-9613354 1.681290e-01 0.774 0 0
FasL/ CD95L signaling R-HSA-75157 4.436275e-01 0.353 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.374686e-01 0.862 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.214736e-01 0.493 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.599624e-01 0.252 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.324223e-01 0.364 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.086664e-01 0.216 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.557349e-01 0.255 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.062951e-01 0.217 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.917245e-01 0.228 0 0
Interleukin-15 signaling R-HSA-8983432 5.594952e-01 0.252 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.877470e-01 0.231 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.528036e-01 0.344 0 0
TRAIL signaling R-HSA-75158 6.086664e-01 0.216 0 0
Base Excision Repair R-HSA-73884 2.773343e-01 0.557 0 0
OAS antiviral response R-HSA-8983711 5.594952e-01 0.252 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.372867e-01 0.359 0 0
IRE1alpha activates chaperones R-HSA-381070 5.204988e-01 0.284 0 0
HDL assembly R-HSA-8963896 3.531966e-01 0.452 0 0
Signaling by Leptin R-HSA-2586552 4.503076e-01 0.346 0 0
Gene Silencing by RNA R-HSA-211000 2.393034e-01 0.621 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.086933e-01 0.216 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.086933e-01 0.216 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.086933e-01 0.216 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.117328e-01 0.213 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.130819e-01 0.212 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.130819e-01 0.212 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.136656e-01 0.212 0 0
Muscle contraction R-HSA-397014 6.179919e-01 0.209 0 0
Signaling by FGFR1 R-HSA-5654736 6.227594e-01 0.206 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.227594e-01 0.206 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.232147e-01 0.205 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.232147e-01 0.205 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.232147e-01 0.205 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.232147e-01 0.205 0 0
Signal regulatory protein family interactions R-HSA-391160 6.232147e-01 0.205 0 0
Recycling pathway of L1 R-HSA-437239 6.237913e-01 0.205 1 1
Signaling by ALK R-HSA-201556 6.259326e-01 0.203 0 0
EGFR downregulation R-HSA-182971 6.299257e-01 0.201 0 0
Budding and maturation of HIV virion R-HSA-162588 6.299257e-01 0.201 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.373467e-01 0.196 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.373467e-01 0.196 0 0
FGFR2 alternative splicing R-HSA-6803529 6.373467e-01 0.196 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.373467e-01 0.196 0 0
MHC class II antigen presentation R-HSA-2132295 6.390861e-01 0.194 0 0
Metal ion SLC transporters R-HSA-425410 6.408324e-01 0.193 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.408324e-01 0.193 0 0
Aggrephagy R-HSA-9646399 6.444628e-01 0.191 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.490951e-01 0.188 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.504039e-01 0.187 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.504039e-01 0.187 0 0
Adipogenesis R-HSA-9843745 6.504480e-01 0.187 0 0
STAT5 Activation R-HSA-9645135 6.519824e-01 0.186 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.519824e-01 0.186 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.519824e-01 0.186 0 0
Defective CYP11A1 causes AICSR R-HSA-5579026 6.519824e-01 0.186 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.519824e-01 0.186 0 0
Neurofascin interactions R-HSA-447043 6.519824e-01 0.186 0 0
NADPH regeneration R-HSA-389542 6.519824e-01 0.186 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.519824e-01 0.186 0 0
Lipid particle organization R-HSA-8964572 6.519824e-01 0.186 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.522956e-01 0.186 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.522956e-01 0.186 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.522956e-01 0.186 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.522956e-01 0.186 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.522956e-01 0.186 0 0
Degradation of CDH1 R-HSA-9766229 6.574032e-01 0.182 0 0
L1CAM interactions R-HSA-373760 6.603664e-01 0.180 1 0
Formation of the ureteric bud R-HSA-9830674 6.605251e-01 0.180 0 0
Growth hormone receptor signaling R-HSA-982772 6.605251e-01 0.180 0 0
S Phase R-HSA-69242 6.616073e-01 0.179 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.624066e-01 0.179 0 0
Regulated Necrosis R-HSA-5218859 6.660738e-01 0.176 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.701124e-01 0.174 0 0
G-protein beta:gamma signalling R-HSA-397795 6.701124e-01 0.174 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.701124e-01 0.174 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.724264e-01 0.172 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.734914e-01 0.172 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.734914e-01 0.172 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.770757e-01 0.169 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.795575e-01 0.168 0 0
Killing mechanisms R-HSA-9664420 6.795575e-01 0.168 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.795575e-01 0.168 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.795575e-01 0.168 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.795575e-01 0.168 0 0
Negative regulation of FLT3 R-HSA-9706369 6.795575e-01 0.168 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 6.795575e-01 0.168 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.795575e-01 0.168 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.797517e-01 0.168 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.826109e-01 0.166 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.826109e-01 0.166 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.826109e-01 0.166 0 0
TNFs bind their physiological receptors R-HSA-5669034 6.826109e-01 0.166 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.826109e-01 0.166 0 0
Signaling by ERBB2 R-HSA-1227986 6.837904e-01 0.165 0 0
HSF1-dependent transactivation R-HSA-3371571 6.890872e-01 0.162 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.899243e-01 0.161 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.905060e-01 0.161 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.905060e-01 0.161 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.905060e-01 0.161 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.905060e-01 0.161 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.905060e-01 0.161 0 0
Disinhibition of SNARE formation R-HSA-114516 6.905060e-01 0.161 0 0
mRNA Editing: C to U Conversion R-HSA-72200 6.905060e-01 0.161 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.905060e-01 0.161 0 0
Electron transport from NADPH to Ferredoxin R-HSA-2395516 6.905060e-01 0.161 0 0
VLDL clearance R-HSA-8964046 6.905060e-01 0.161 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.905060e-01 0.161 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.905060e-01 0.161 0 0
Glycoprotein hormones R-HSA-209822 6.905060e-01 0.161 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.905060e-01 0.161 0 0
CHL1 interactions R-HSA-447041 6.905060e-01 0.161 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.905060e-01 0.161 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.921118e-01 0.160 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.921118e-01 0.160 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.934139e-01 0.159 0 0
Interleukin-17 signaling R-HSA-448424 6.934139e-01 0.159 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.980204e-01 0.156 0 0
Signaling by MET R-HSA-6806834 7.024510e-01 0.153 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.036073e-01 0.153 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.036073e-01 0.153 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.036073e-01 0.153 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.036073e-01 0.153 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.037993e-01 0.153 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.050469e-01 0.152 0 0
Phase 2 - plateau phase R-HSA-5576893 7.050469e-01 0.152 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.050469e-01 0.152 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.050469e-01 0.152 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.050469e-01 0.152 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.050469e-01 0.152 0 0
Passive transport by Aquaporins R-HSA-432047 7.050469e-01 0.152 0 0
Synthesis of PG R-HSA-1483148 7.050469e-01 0.152 0 0
Response to metal ions R-HSA-5660526 7.050469e-01 0.152 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.065368e-01 0.151 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.065368e-01 0.151 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.071873e-01 0.150 0 0
Mitophagy R-HSA-5205647 7.071873e-01 0.150 0 0
Potassium Channels R-HSA-1296071 7.080370e-01 0.150 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.118250e-01 0.148 0 0
Signaling by PDGF R-HSA-186797 7.118250e-01 0.148 0 0
Ion channel transport R-HSA-983712 7.144738e-01 0.146 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.146513e-01 0.146 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.220460e-01 0.141 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.220460e-01 0.141 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.235248e-01 0.141 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.235248e-01 0.141 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.245499e-01 0.140 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.245499e-01 0.140 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.247673e-01 0.140 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.247673e-01 0.140 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.247673e-01 0.140 0 0
Activation of RAS in B cells R-HSA-1169092 7.247673e-01 0.140 0 0
MET receptor recycling R-HSA-8875656 7.247673e-01 0.140 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.247673e-01 0.140 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.247673e-01 0.140 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.247673e-01 0.140 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.247673e-01 0.140 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.247673e-01 0.140 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.247673e-01 0.140 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.247673e-01 0.140 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.247673e-01 0.140 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.252002e-01 0.140 0 0
DAP12 interactions R-HSA-2172127 7.281245e-01 0.138 0 0
Amine ligand-binding receptors R-HSA-375280 7.281245e-01 0.138 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.288219e-01 0.137 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.288219e-01 0.137 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.288219e-01 0.137 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.288219e-01 0.137 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.288219e-01 0.137 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.288219e-01 0.137 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.288219e-01 0.137 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.288219e-01 0.137 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.288219e-01 0.137 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.288219e-01 0.137 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.316650e-01 0.136 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.339940e-01 0.134 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.378064e-01 0.132 0 0
Host Interactions of HIV factors R-HSA-162909 7.409547e-01 0.130 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.411343e-01 0.130 0 0
G1/S-Specific Transcription R-HSA-69205 7.411343e-01 0.130 0 0
HCMV Late Events R-HSA-9610379 7.420946e-01 0.130 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.423807e-01 0.129 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.423807e-01 0.129 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.430209e-01 0.129 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.430209e-01 0.129 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.467275e-01 0.127 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.467275e-01 0.127 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.506544e-01 0.125 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.509498e-01 0.124 0 0
Apoptotic factor-mediated response R-HSA-111471 7.509498e-01 0.124 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.509498e-01 0.124 0 0
Mismatch Repair R-HSA-5358508 7.509498e-01 0.124 0 0
Tie2 Signaling R-HSA-210993 7.509498e-01 0.124 0 0
Platelet sensitization by LDL R-HSA-432142 7.509498e-01 0.124 0 0
Cellular responses to stress R-HSA-2262752 7.512047e-01 0.124 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.548385e-01 0.122 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.552376e-01 0.122 0 0
Interleukin-21 signaling R-HSA-9020958 7.552376e-01 0.122 0 0
WNT mediated activation of DVL R-HSA-201688 7.552376e-01 0.122 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.552376e-01 0.122 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.552376e-01 0.122 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.552376e-01 0.122 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.552376e-01 0.122 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.552376e-01 0.122 0 0
mRNA Editing R-HSA-75072 7.552376e-01 0.122 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.552376e-01 0.122 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.552376e-01 0.122 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.552376e-01 0.122 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.569488e-01 0.121 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.573070e-01 0.121 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.573070e-01 0.121 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.573070e-01 0.121 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.595120e-01 0.119 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.595120e-01 0.119 0 0
Potential therapeutics for SARS R-HSA-9679191 7.601129e-01 0.119 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.601977e-01 0.119 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.601977e-01 0.119 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.650525e-01 0.116 0 0
HCMV Early Events R-HSA-9609690 7.670160e-01 0.115 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.706594e-01 0.113 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.709884e-01 0.113 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.709884e-01 0.113 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.715037e-01 0.113 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.715037e-01 0.113 0 0
Regulation of CDH1 Function R-HSA-9764561 7.720819e-01 0.112 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.770028e-01 0.110 0 0
mRNA Capping R-HSA-72086 7.770028e-01 0.110 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.770028e-01 0.110 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.774010e-01 0.109 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.823362e-01 0.107 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.823362e-01 0.107 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.823362e-01 0.107 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.823362e-01 0.107 0 0
Pexophagy R-HSA-9664873 7.823362e-01 0.107 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.823362e-01 0.107 0 0
Maturation of spike protein R-HSA-9683686 7.823362e-01 0.107 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.823362e-01 0.107 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.823362e-01 0.107 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.823362e-01 0.107 0 0
Peptide hormone biosynthesis R-HSA-209952 7.823362e-01 0.107 0 0
Josephin domain DUBs R-HSA-5689877 7.823362e-01 0.107 0 0
Inositol phosphate metabolism R-HSA-1483249 7.837665e-01 0.106 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.884468e-01 0.103 0 0
Leishmania infection R-HSA-9658195 7.896536e-01 0.103 0 0
Parasitic Infection Pathways R-HSA-9824443 7.896536e-01 0.103 0 0
Pregnenolone biosynthesis R-HSA-196108 7.905610e-01 0.102 0 0
Signaling by NODAL R-HSA-1181150 7.905610e-01 0.102 0 0
Nephrin family interactions R-HSA-373753 7.905610e-01 0.102 0 0
Activation of the pre-replicative complex R-HSA-68962 7.928268e-01 0.101 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.928268e-01 0.101 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.928268e-01 0.101 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.928268e-01 0.101 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.938872e-01 0.100 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.999045e-01 0.097 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.999045e-01 0.097 0 0
Diseases of Immune System R-HSA-5260271 7.999045e-01 0.097 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.999045e-01 0.097 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.999045e-01 0.097 0 0
Peptide chain elongation R-HSA-156902 8.002561e-01 0.097 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.064360e-01 0.093 0 0
LGI-ADAM interactions R-HSA-5682910 8.064360e-01 0.093 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.064360e-01 0.093 0 0
Interleukin-2 signaling R-HSA-9020558 8.064360e-01 0.093 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.064360e-01 0.093 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.064360e-01 0.093 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.064360e-01 0.093 0 0
Bicarbonate transporters R-HSA-425381 8.064360e-01 0.093 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.064360e-01 0.093 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.064360e-01 0.093 0 0
PECAM1 interactions R-HSA-210990 8.064360e-01 0.093 0 0
Suppression of apoptosis R-HSA-9635465 8.064360e-01 0.093 0 0
Transport of RCbl within the body R-HSA-9758890 8.064360e-01 0.093 0 0
Prostanoid ligand receptors R-HSA-391908 8.064360e-01 0.093 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.067829e-01 0.093 0 0
GABA receptor activation R-HSA-977443 8.068300e-01 0.093 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.077033e-01 0.093 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.077033e-01 0.093 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.082009e-01 0.092 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.082009e-01 0.092 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.082009e-01 0.092 0 0
Signalling to RAS R-HSA-167044 8.082009e-01 0.092 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.082009e-01 0.092 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.082009e-01 0.092 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.082009e-01 0.092 0 0
Basigin interactions R-HSA-210991 8.082009e-01 0.092 0 0
PTEN Regulation R-HSA-6807070 8.115967e-01 0.091 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.116197e-01 0.091 0 0
Hedgehog 'on' state R-HSA-5632684 8.167524e-01 0.088 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.198510e-01 0.086 0 0
Signaling by FGFR R-HSA-190236 8.200463e-01 0.086 0 0
DNA strand elongation R-HSA-69190 8.216678e-01 0.085 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.245037e-01 0.084 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.245037e-01 0.084 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.245037e-01 0.084 0 0
Attachment and Entry R-HSA-9694614 8.245037e-01 0.084 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.245037e-01 0.084 0 0
Assembly Of The HIV Virion R-HSA-175474 8.245037e-01 0.084 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.249743e-01 0.084 0 0
HIV Transcription Initiation R-HSA-167161 8.249743e-01 0.084 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.249743e-01 0.084 0 0
Intra-Golgi traffic R-HSA-6811438 8.249743e-01 0.084 0 0
Translation of Structural Proteins R-HSA-9683701 8.249743e-01 0.084 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.263172e-01 0.083 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.269120e-01 0.083 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.276036e-01 0.082 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.278688e-01 0.082 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.278688e-01 0.082 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.278688e-01 0.082 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.278688e-01 0.082 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.278688e-01 0.082 0 0
ERKs are inactivated R-HSA-202670 8.278688e-01 0.082 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.278688e-01 0.082 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.278688e-01 0.082 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.278688e-01 0.082 0 0
Sodium/Calcium exchangers R-HSA-425561 8.278688e-01 0.082 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.278688e-01 0.082 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.306605e-01 0.081 0 0
Orc1 removal from chromatin R-HSA-68949 8.306605e-01 0.081 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.306605e-01 0.081 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.318345e-01 0.080 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.318345e-01 0.080 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.347576e-01 0.078 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.348961e-01 0.078 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 8.373013e-01 0.077 0 0
Signaling by PTK6 R-HSA-8848021 8.373013e-01 0.077 0 0
Notch-HLH transcription pathway R-HSA-350054 8.395491e-01 0.076 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.395491e-01 0.076 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.395491e-01 0.076 0 0
Signaling by KIT in disease R-HSA-9669938 8.395491e-01 0.076 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 8.395491e-01 0.076 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.395491e-01 0.076 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.395491e-01 0.076 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.401527e-01 0.076 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.409356e-01 0.075 0 0
Smooth Muscle Contraction R-HSA-445355 8.409356e-01 0.075 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.409356e-01 0.075 0 0
Signaling by Insulin receptor R-HSA-74752 8.431031e-01 0.074 0 0
Signaling by NOTCH4 R-HSA-9013694 8.442643e-01 0.074 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.469294e-01 0.072 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.469294e-01 0.072 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.469294e-01 0.072 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.469294e-01 0.072 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.469294e-01 0.072 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.469294e-01 0.072 0 0
MET activates RAS signaling R-HSA-8851805 8.469294e-01 0.072 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.469294e-01 0.072 0 0
Repression of WNT target genes R-HSA-4641265 8.469294e-01 0.072 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.469294e-01 0.072 0 0
Polymerase switching R-HSA-69091 8.469294e-01 0.072 0 0
Leading Strand Synthesis R-HSA-69109 8.469294e-01 0.072 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.469294e-01 0.072 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.469294e-01 0.072 0 0
Estrogen biosynthesis R-HSA-193144 8.469294e-01 0.072 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.469294e-01 0.072 0 0
Striated Muscle Contraction R-HSA-390522 8.470107e-01 0.072 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.470107e-01 0.072 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.470107e-01 0.072 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.470107e-01 0.072 0 0
Neutrophil degranulation R-HSA-6798695 8.472389e-01 0.072 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.473838e-01 0.072 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.473838e-01 0.072 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.473838e-01 0.072 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.506921e-01 0.070 0 0
Toll-like Receptor Cascades R-HSA-168898 8.516527e-01 0.070 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.526636e-01 0.069 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.534156e-01 0.069 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.534156e-01 0.069 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.534156e-01 0.069 0 0
Carnitine shuttle R-HSA-200425 8.534156e-01 0.069 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.534156e-01 0.069 0 0
Cellular response to hypoxia R-HSA-1234174 8.553737e-01 0.068 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.576486e-01 0.067 0 0
Dual Incision in GG-NER R-HSA-5696400 8.584659e-01 0.066 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.589808e-01 0.066 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.599462e-01 0.066 0 0
Signaling by NOTCH3 R-HSA-9012852 8.599462e-01 0.066 0 0
Interleukin-12 signaling R-HSA-9020591 8.606924e-01 0.065 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.628746e-01 0.064 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.629117e-01 0.064 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.638805e-01 0.064 0 0
FGFR2c ligand binding and activation R-HSA-190375 8.638805e-01 0.064 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.638805e-01 0.064 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.638805e-01 0.064 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.638805e-01 0.064 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 8.638805e-01 0.064 0 0
Chylomicron remodeling R-HSA-8963901 8.638805e-01 0.064 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.638805e-01 0.064 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.638805e-01 0.064 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.638805e-01 0.064 0 0
FGFR3 mutant receptor activation R-HSA-2033514 8.638805e-01 0.064 0 0
Processing of SMDT1 R-HSA-8949664 8.638805e-01 0.064 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.638805e-01 0.064 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.638805e-01 0.064 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 8.638805e-01 0.064 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.638805e-01 0.064 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.638805e-01 0.064 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.638805e-01 0.064 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.651277e-01 0.063 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.651277e-01 0.063 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.661798e-01 0.062 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.661798e-01 0.062 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.662675e-01 0.062 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.673187e-01 0.062 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.673187e-01 0.062 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.673187e-01 0.062 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.673187e-01 0.062 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.684807e-01 0.061 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.687147e-01 0.061 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.691619e-01 0.061 0 0
Eukaryotic Translation Termination R-HSA-72764 8.718908e-01 0.060 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.728023e-01 0.059 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.764187e-01 0.057 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.779157e-01 0.057 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.779157e-01 0.057 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.779157e-01 0.057 0 0
Removal of the Flap Intermediate R-HSA-69166 8.789552e-01 0.056 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.789552e-01 0.056 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.789552e-01 0.056 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.789552e-01 0.056 0 0
Prolactin receptor signaling R-HSA-1170546 8.789552e-01 0.056 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.789552e-01 0.056 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.789552e-01 0.056 0 0
FGFR3c ligand binding and activation R-HSA-190372 8.789552e-01 0.056 0 0
Physiological factors R-HSA-5578768 8.789552e-01 0.056 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.789552e-01 0.056 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.791375e-01 0.056 0 0
RNA Polymerase III Transcription R-HSA-74158 8.791375e-01 0.056 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.791375e-01 0.056 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.791375e-01 0.056 0 0
Dual incision in TC-NER R-HSA-6782135 8.848641e-01 0.053 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.849731e-01 0.053 0 0
Signaling by TGFB family members R-HSA-9006936 8.850141e-01 0.053 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.884308e-01 0.051 0 0
Degradation of DVL R-HSA-4641258 8.884308e-01 0.051 0 0
SLC-mediated transport of organic cations R-HSA-549127 8.884308e-01 0.051 0 0
MET activates PTK2 signaling R-HSA-8874081 8.886944e-01 0.051 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.886944e-01 0.051 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.886944e-01 0.051 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.886944e-01 0.051 0 0
Sphingolipid catabolism R-HSA-9845614 8.886944e-01 0.051 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.892002e-01 0.051 0 0
Extension of Telomeres R-HSA-180786 8.922798e-01 0.049 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.923613e-01 0.049 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 8.923613e-01 0.049 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.923613e-01 0.049 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.923613e-01 0.049 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.923613e-01 0.049 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.923613e-01 0.049 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.923613e-01 0.049 0 0
Translesion synthesis by REV1 R-HSA-110312 8.923613e-01 0.049 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.923613e-01 0.049 0 0
Signaling by Activin R-HSA-1502540 8.923613e-01 0.049 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.923613e-01 0.049 0 0
p38MAPK events R-HSA-171007 8.923613e-01 0.049 0 0
Biotin transport and metabolism R-HSA-196780 8.923613e-01 0.049 0 0
FGFR3 ligand binding and activation R-HSA-190239 8.923613e-01 0.049 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.923613e-01 0.049 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.923613e-01 0.049 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.923613e-01 0.049 0 0
Protein lipoylation R-HSA-9857492 8.923613e-01 0.049 0 0
Protein methylation R-HSA-8876725 8.923613e-01 0.049 0 0
DNA Damage Reversal R-HSA-73942 8.923613e-01 0.049 0 0
Downstream TCR signaling R-HSA-202424 8.926087e-01 0.049 0 0
Intraflagellar transport R-HSA-5620924 8.930064e-01 0.049 0 0
G1/S Transition R-HSA-69206 8.932836e-01 0.049 0 0
COPII-mediated vesicle transport R-HSA-204005 8.934144e-01 0.049 0 0
Phospholipid metabolism R-HSA-1483257 8.946825e-01 0.048 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.970792e-01 0.047 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 8.982655e-01 0.047 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.985840e-01 0.046 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.985840e-01 0.046 0 0
Signaling by BMP R-HSA-201451 8.985840e-01 0.046 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.985840e-01 0.046 0 0
Triglyceride biosynthesis R-HSA-75109 8.985840e-01 0.046 0 0
Synthesis of PE R-HSA-1483213 8.985840e-01 0.046 0 0
RAB geranylgeranylation R-HSA-8873719 8.992797e-01 0.046 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.999029e-01 0.046 0 0
Signaling by NOTCH R-HSA-157118 9.027689e-01 0.044 0 0
HCMV Infection R-HSA-9609646 9.040670e-01 0.044 0 0
Translesion synthesis by POLI R-HSA-5656121 9.042833e-01 0.044 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.042833e-01 0.044 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.042833e-01 0.044 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.042833e-01 0.044 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 9.042833e-01 0.044 0 0
Activation of SMO R-HSA-5635838 9.042833e-01 0.044 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.042833e-01 0.044 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 9.042833e-01 0.044 0 0
Attachment and Entry R-HSA-9678110 9.042833e-01 0.044 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.051194e-01 0.043 0 0
Stabilization of p53 R-HSA-69541 9.051194e-01 0.043 0 0
Selenocysteine synthesis R-HSA-2408557 9.068803e-01 0.042 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.072121e-01 0.042 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.076492e-01 0.042 0 0
Pyroptosis R-HSA-5620971 9.076492e-01 0.042 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.118486e-01 0.040 0 0
Ca2+ pathway R-HSA-4086398 9.118672e-01 0.040 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.121016e-01 0.040 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.125867e-01 0.040 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.125867e-01 0.040 0 0
GPCR downstream signalling R-HSA-388396 9.138300e-01 0.039 0 0
Translesion synthesis by POLK R-HSA-5655862 9.148854e-01 0.039 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.148854e-01 0.039 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.148854e-01 0.039 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.148854e-01 0.039 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.148854e-01 0.039 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.148854e-01 0.039 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.148854e-01 0.039 0 0
Coenzyme A biosynthesis R-HSA-196783 9.148854e-01 0.039 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.148854e-01 0.039 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.148854e-01 0.039 0 0
Ribosome-associated quality control R-HSA-9948299 9.155461e-01 0.038 0 0
Viral mRNA Translation R-HSA-192823 9.165901e-01 0.038 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.195156e-01 0.036 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.195156e-01 0.036 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.211125e-01 0.036 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.222121e-01 0.035 0 0
Gastrulation R-HSA-9758941 9.226853e-01 0.035 0 0
Ion transport by P-type ATPases R-HSA-936837 9.234672e-01 0.035 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.235477e-01 0.035 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.235477e-01 0.035 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.235477e-01 0.035 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.243137e-01 0.034 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.243137e-01 0.034 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.243137e-01 0.034 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.243137e-01 0.034 0 0
Glycogen storage diseases R-HSA-3229121 9.243137e-01 0.034 0 0
Catecholamine biosynthesis R-HSA-209905 9.243137e-01 0.034 0 0
Choline catabolism R-HSA-6798163 9.243137e-01 0.034 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.259391e-01 0.033 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.259391e-01 0.033 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.261959e-01 0.033 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.268103e-01 0.033 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.269946e-01 0.033 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.288120e-01 0.032 0 0
Cellular response to chemical stress R-HSA-9711123 9.292827e-01 0.032 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.304932e-01 0.031 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.304932e-01 0.031 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.304932e-01 0.031 0 0
Cargo concentration in the ER R-HSA-5694530 9.304932e-01 0.031 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.304932e-01 0.031 0 0
Translation initiation complex formation R-HSA-72649 9.315995e-01 0.031 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.315995e-01 0.031 0 0
Interleukin-12 family signaling R-HSA-447115 9.318675e-01 0.031 0 0
Activation of GABAB receptors R-HSA-991365 9.318890e-01 0.031 0 0
GABA B receptor activation R-HSA-977444 9.318890e-01 0.031 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.318890e-01 0.031 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.318890e-01 0.031 0 0
Translation of Structural Proteins R-HSA-9694635 9.321153e-01 0.031 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.326982e-01 0.030 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.326982e-01 0.030 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.326982e-01 0.030 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.326982e-01 0.030 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.326982e-01 0.030 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.326982e-01 0.030 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.326982e-01 0.030 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.326982e-01 0.030 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.330150e-01 0.030 0 0
Platelet homeostasis R-HSA-418346 9.334385e-01 0.030 0 0
PCP/CE pathway R-HSA-4086400 9.364857e-01 0.028 0 0
Interleukin-10 signaling R-HSA-6783783 9.364857e-01 0.028 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.368387e-01 0.028 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.368387e-01 0.028 0 0
Synthesis of DNA R-HSA-69239 9.371580e-01 0.028 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.373290e-01 0.028 0 0
Pyrimidine biosynthesis R-HSA-500753 9.401542e-01 0.027 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.401542e-01 0.027 0 0
Translesion Synthesis by POLH R-HSA-110320 9.401542e-01 0.027 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.401542e-01 0.027 0 0
Diseases of hemostasis R-HSA-9671793 9.401542e-01 0.027 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.401542e-01 0.027 0 0
Other interleukin signaling R-HSA-449836 9.401542e-01 0.027 0 0
Developmental Cell Lineages R-HSA-9734767 9.411011e-01 0.026 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.413454e-01 0.026 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.413454e-01 0.026 0 0
PPARA activates gene expression R-HSA-1989781 9.421456e-01 0.026 0 0
Proteasome assembly R-HSA-9907900 9.424880e-01 0.026 0 0
Cyclin D associated events in G1 R-HSA-69231 9.424880e-01 0.026 0 0
G1 Phase R-HSA-69236 9.424880e-01 0.026 0 0
RMTs methylate histone arginines R-HSA-3214858 9.424880e-01 0.026 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.424880e-01 0.026 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.426318e-01 0.026 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.467847e-01 0.024 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.467847e-01 0.024 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 9.467847e-01 0.024 0 0
Glycogen synthesis R-HSA-3322077 9.467847e-01 0.024 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.467847e-01 0.024 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.467847e-01 0.024 0 0
Negative regulation of MET activity R-HSA-6807004 9.467847e-01 0.024 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.467847e-01 0.024 0 0
Somitogenesis R-HSA-9824272 9.471938e-01 0.024 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.471938e-01 0.024 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.476194e-01 0.023 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.479170e-01 0.023 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.479170e-01 0.023 0 0
Heme degradation R-HSA-189483 9.479170e-01 0.023 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.479170e-01 0.023 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.498085e-01 0.022 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.498085e-01 0.022 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.515390e-01 0.022 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.526808e-01 0.021 0 0
G-protein activation R-HSA-202040 9.526808e-01 0.021 0 0
Lagging Strand Synthesis R-HSA-69186 9.526808e-01 0.021 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.526808e-01 0.021 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.526808e-01 0.021 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.526808e-01 0.021 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.526808e-01 0.021 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.526808e-01 0.021 0 0
Signal amplification R-HSA-392518 9.527357e-01 0.021 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.527357e-01 0.021 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.527357e-01 0.021 0 0
Signaling by NOTCH2 R-HSA-1980145 9.527357e-01 0.021 0 0
Influenza Infection R-HSA-168255 9.533065e-01 0.021 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.536057e-01 0.021 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.536132e-01 0.021 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.547927e-01 0.020 0 0
Leishmania phagocytosis R-HSA-9664417 9.550985e-01 0.020 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.550985e-01 0.020 0 0
Parasite infection R-HSA-9664407 9.550985e-01 0.020 0 0
Oncogene Induced Senescence R-HSA-2559585 9.571264e-01 0.019 0 0
PERK regulates gene expression R-HSA-381042 9.571264e-01 0.019 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.571264e-01 0.019 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.571264e-01 0.019 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.571264e-01 0.019 0 0
Regulation of Apoptosis R-HSA-169911 9.571264e-01 0.019 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.571366e-01 0.019 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.579240e-01 0.019 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.579240e-01 0.019 0 0
Glutathione synthesis and recycling R-HSA-174403 9.579240e-01 0.019 0 0
Collagen formation R-HSA-1474290 9.593382e-01 0.018 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.604177e-01 0.018 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.611247e-01 0.017 0 0
HSF1 activation R-HSA-3371511 9.611247e-01 0.017 0 0
Glycosphingolipid transport R-HSA-9845576 9.611247e-01 0.017 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.618817e-01 0.017 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.622459e-01 0.017 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.625865e-01 0.017 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.625865e-01 0.017 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.625865e-01 0.017 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.625865e-01 0.017 0 0
Ethanol oxidation R-HSA-71384 9.625865e-01 0.017 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.625865e-01 0.017 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.625865e-01 0.017 0 0
LDL clearance R-HSA-8964038 9.625865e-01 0.017 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.625865e-01 0.017 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.626527e-01 0.017 0 0
SARS-CoV Infections R-HSA-9679506 9.626874e-01 0.017 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.645393e-01 0.016 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.647637e-01 0.016 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.647637e-01 0.016 0 0
Degradation of AXIN R-HSA-4641257 9.647637e-01 0.016 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.647637e-01 0.016 0 0
NCAM1 interactions R-HSA-419037 9.647637e-01 0.016 0 0
Collagen chain trimerization R-HSA-8948216 9.647637e-01 0.016 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.655633e-01 0.015 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.667326e-01 0.015 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.667326e-01 0.015 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.667326e-01 0.015 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.667326e-01 0.015 0 0
Biosynthesis of maresins R-HSA-9018682 9.667326e-01 0.015 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.667326e-01 0.015 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.667326e-01 0.015 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.667326e-01 0.015 0 0
Elastic fibre formation R-HSA-1566948 9.680738e-01 0.014 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.686780e-01 0.014 0 0
The phototransduction cascade R-HSA-2514856 9.686780e-01 0.014 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.692796e-01 0.014 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.695531e-01 0.013 0 0
CYP2E1 reactions R-HSA-211999 9.704194e-01 0.013 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.704194e-01 0.013 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.704194e-01 0.013 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.704194e-01 0.013 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.704194e-01 0.013 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.704194e-01 0.013 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.704194e-01 0.013 0 0
Pentose phosphate pathway R-HSA-71336 9.710833e-01 0.013 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.710833e-01 0.013 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.710833e-01 0.013 0 0
Cellular response to starvation R-HSA-9711097 9.714954e-01 0.013 0 0
ABC transporter disorders R-HSA-5619084 9.725724e-01 0.012 0 0
Integrin cell surface interactions R-HSA-216083 9.725724e-01 0.012 0 0
G protein gated Potassium channels R-HSA-1296059 9.736979e-01 0.012 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.736979e-01 0.012 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.736979e-01 0.012 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.736979e-01 0.012 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.736979e-01 0.012 0 0
Hyaluronan degradation R-HSA-2160916 9.736979e-01 0.012 0 0
Laminin interactions R-HSA-3000157 9.736979e-01 0.012 0 0
Neddylation R-HSA-8951664 9.738028e-01 0.012 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.738181e-01 0.012 0 0
Attenuation phase R-HSA-3371568 9.738181e-01 0.012 0 0
ABC-family proteins mediated transport R-HSA-382556 9.746906e-01 0.011 0 0
Maturation of spike protein R-HSA-9694548 9.763022e-01 0.010 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.763022e-01 0.010 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.763022e-01 0.010 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.766131e-01 0.010 0 0
Metalloprotease DUBs R-HSA-5689901 9.766131e-01 0.010 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.766131e-01 0.010 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.776146e-01 0.010 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.780794e-01 0.010 0 0
G alpha (z) signalling events R-HSA-418597 9.780794e-01 0.010 0 0
Paracetamol ADME R-HSA-9753281 9.780794e-01 0.010 0 0
Signaling by GPCR R-HSA-372790 9.782385e-01 0.010 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.785574e-01 0.009 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.792054e-01 0.009 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.792054e-01 0.009 0 0
Insulin processing R-HSA-264876 9.792054e-01 0.009 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.815105e-01 0.008 0 0
RSV-host interactions R-HSA-9833110 9.821700e-01 0.008 0 0
Defensins R-HSA-1461973 9.824605e-01 0.008 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.824605e-01 0.008 0 0
ECM proteoglycans R-HSA-3000178 9.825741e-01 0.008 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.827923e-01 0.008 0 0
SLC transporter disorders R-HSA-5619102 9.828730e-01 0.008 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.832950e-01 0.007 0 0
Nucleotide Excision Repair R-HSA-5696398 9.833945e-01 0.007 0 0
Thyroxine biosynthesis R-HSA-209968 9.835602e-01 0.007 0 0
Glucagon-type ligand receptors R-HSA-420092 9.835602e-01 0.007 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.835602e-01 0.007 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.835602e-01 0.007 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.835629e-01 0.007 0 0
Surfactant metabolism R-HSA-5683826 9.841439e-01 0.007 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.847525e-01 0.007 0 0
rRNA processing R-HSA-72312 9.848571e-01 0.007 0 0
Interferon gamma signaling R-HSA-877300 9.857462e-01 0.006 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.860876e-01 0.006 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.860876e-01 0.006 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.860876e-01 0.006 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.860876e-01 0.006 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.860876e-01 0.006 0 0
tRNA Aminoacylation R-HSA-379724 9.860876e-01 0.006 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.860876e-01 0.006 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.864400e-01 0.006 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.870034e-01 0.006 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.870034e-01 0.006 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.870523e-01 0.006 0 0
Collagen degradation R-HSA-1442490 9.873101e-01 0.006 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.874841e-01 0.005 0 0
Iron uptake and transport R-HSA-917937 9.875862e-01 0.005 0 0
Synthesis of PC R-HSA-1483191 9.883045e-01 0.005 0 0
Mitochondrial protein import R-HSA-1268020 9.884290e-01 0.005 0 0
HS-GAG degradation R-HSA-2024096 9.884444e-01 0.005 0 0
Signaling by NOTCH1 R-HSA-1980143 9.886054e-01 0.005 0 0
UCH proteinases R-HSA-5689603 9.886054e-01 0.005 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.886630e-01 0.005 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.886630e-01 0.005 0 0
ER-Phagosome pathway R-HSA-1236974 9.893484e-01 0.005 0 0
Neurotransmitter release cycle R-HSA-112310 9.901787e-01 0.004 0 0
Cholesterol biosynthesis R-HSA-191273 9.904093e-01 0.004 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.904646e-01 0.004 0 0
Gap junction trafficking and regulation R-HSA-157858 9.904646e-01 0.004 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.904646e-01 0.004 0 0
G alpha (i) signalling events R-HSA-418594 9.906464e-01 0.004 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.908650e-01 0.004 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.908650e-01 0.004 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.918780e-01 0.004 0 0
eNOS activation R-HSA-203615 9.918780e-01 0.004 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.918780e-01 0.004 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.918780e-01 0.004 0 0
Hyaluronan metabolism R-HSA-2142845 9.918780e-01 0.004 0 0
RA biosynthesis pathway R-HSA-5365859 9.918780e-01 0.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.918780e-01 0.004 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.920261e-01 0.003 0 0
Complex IV assembly R-HSA-9864848 9.922332e-01 0.003 0 0
Protein folding R-HSA-391251 9.923160e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.923160e-01 0.003 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.923597e-01 0.003 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.927403e-01 0.003 0 0
Metabolism of steroid hormones R-HSA-196071 9.927403e-01 0.003 0 0
Nicotinate metabolism R-HSA-196807 9.927403e-01 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.927788e-01 0.003 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.927788e-01 0.003 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.933924e-01 0.003 0 0
HS-GAG biosynthesis R-HSA-2022928 9.935797e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.935797e-01 0.003 0 0
Hemostasis R-HSA-109582 9.938489e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.942918e-01 0.002 0 0
Lysine catabolism R-HSA-71064 9.942918e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.945306e-01 0.002 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.948407e-01 0.002 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.949250e-01 0.002 0 0
Purine salvage R-HSA-74217 9.949250e-01 0.002 0 0
Selenoamino acid metabolism R-HSA-2408522 9.950152e-01 0.002 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.950260e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.950260e-01 0.002 0 0
Immune System R-HSA-168256 9.951977e-01 0.002 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.953674e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.954879e-01 0.002 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.954879e-01 0.002 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.954879e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.957681e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.958248e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.958248e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.959885e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.959885e-01 0.002 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.959885e-01 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.962416e-01 0.002 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.963219e-01 0.002 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.963995e-01 0.002 0 0
Formation of the cornified envelope R-HSA-6809371 9.965413e-01 0.002 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.966063e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.966106e-01 0.001 0 0
tRNA processing R-HSA-72306 9.968970e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.969469e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.971810e-01 0.001 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.973016e-01 0.001 0 0
Pyrimidine catabolism R-HSA-73621 9.974938e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.977719e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.980192e-01 0.001 0 0
Protein localization R-HSA-9609507 9.980562e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.980720e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.984345e-01 0.001 0 0
Interferon Signaling R-HSA-913531 9.985086e-01 0.001 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.985528e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.986082e-01 0.001 0 0
Gluconeogenesis R-HSA-70263 9.986082e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.986849e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.988255e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.989001e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.990435e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.990435e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.991401e-01 0.000 0 0
Platelet degranulation R-HSA-114608 9.991621e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.992270e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.992272e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.992768e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.993052e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.993670e-01 0.000 0 0
Digestion R-HSA-8935690 9.994571e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.995471e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.995932e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.995932e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.996187e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.996191e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.996610e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.996719e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.996738e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.996812e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.996987e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.996987e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.997394e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.997619e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.997884e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.998119e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998165e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998487e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.998514e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999052e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999267e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999268e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999421e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999534e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999586e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999626e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.999664e-01 0.000 0 0
PKR-mediated signaling R-HSA-9833482 9.999679e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999714e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999730e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999784e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999800e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999819e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999820e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999842e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999883e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999896e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999900e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999912e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999945e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999976e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999983e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999987e-01 0.000 0 0
Translation R-HSA-72766 9.999989e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999992e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999993e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999994e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999997e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999999e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 3.330669e-16 15.477 0 0
M Phase R-HSA-68886 1.665335e-14 13.778 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.195844e-14 13.284 0 0
Cellular responses to stress R-HSA-2262752 1.836309e-13 12.736 0 0
Cellular responses to stimuli R-HSA-8953897 3.548273e-13 12.450 0 0
HSF1-dependent transactivation R-HSA-3371571 6.058487e-13 12.218 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.724731e-12 11.763 0 0
Attenuation phase R-HSA-3371568 4.460543e-12 11.351 0 0
HDACs deacetylate histones R-HSA-3214815 1.512201e-11 10.820 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.749223e-11 10.757 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.721434e-11 10.565 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.691924e-11 10.570 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.788880e-11 10.421 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.311940e-11 10.365 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.118006e-11 10.148 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.393719e-11 10.076 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.926993e-11 10.003 0 0
Mitotic Prophase R-HSA-68875 1.394543e-10 9.856 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.714496e-10 9.766 0 0
Meiotic synapsis R-HSA-1221632 1.906028e-10 9.720 0 0
HSF1 activation R-HSA-3371511 1.714496e-10 9.766 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.792697e-10 9.746 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.255059e-10 9.647 0 0
Cell Cycle Checkpoints R-HSA-69620 2.224577e-10 9.653 0 0
Cellular Senescence R-HSA-2559583 2.700177e-10 9.569 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.400575e-10 9.356 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.759014e-10 9.240 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.622645e-10 9.118 0 0
DNA methylation R-HSA-5334118 1.138062e-09 8.944 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.314601e-09 8.881 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.775464e-09 8.751 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.385348e-09 8.622 0 0
G2/M Checkpoints R-HSA-69481 2.309079e-09 8.637 0 0
Metabolism of RNA R-HSA-8953854 2.734281e-09 8.563 0 0
Packaging Of Telomere Ends R-HSA-171306 2.868952e-09 8.542 0 0
DNA Double Strand Break Response R-HSA-5693606 3.060503e-09 8.514 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.184968e-09 8.497 0 0
Cell-Cell communication R-HSA-1500931 3.606326e-09 8.443 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.891932e-09 8.410 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.599988e-09 8.337 0 0
Meiosis R-HSA-1500620 4.944825e-09 8.306 0 0
Axon guidance R-HSA-422475 5.868934e-09 8.231 1 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.763304e-09 8.239 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.763304e-09 8.239 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.580247e-09 8.182 0 0
Chromatin organization R-HSA-4839726 6.933341e-09 8.159 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.844462e-09 8.165 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.024173e-09 8.096 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.258812e-09 8.033 0 0
Gene Silencing by RNA R-HSA-211000 9.394239e-09 8.027 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.346207e-08 7.871 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.391067e-08 7.857 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.626476e-08 7.789 0 0
HATs acetylate histones R-HSA-3214847 1.683838e-08 7.774 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.393403e-08 7.621 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.698392e-08 7.569 0 0
Nucleosome assembly R-HSA-774815 3.462973e-08 7.461 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.462973e-08 7.461 0 0
Chromatin modifying enzymes R-HSA-3247509 3.770776e-08 7.424 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.852225e-08 7.414 0 0
Meiotic recombination R-HSA-912446 4.690251e-08 7.329 0 0
Apoptotic execution phase R-HSA-75153 4.714575e-08 7.327 0 0
Nervous system development R-HSA-9675108 5.839503e-08 7.234 1 0
Defective pyroptosis R-HSA-9710421 8.545580e-08 7.068 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 8.554220e-08 7.068 0 0
Cell junction organization R-HSA-446728 8.894564e-08 7.051 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.163501e-07 6.934 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.286121e-07 6.891 0 0
Signaling by ROBO receptors R-HSA-376176 1.457959e-07 6.836 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.474065e-07 6.831 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.547422e-07 6.810 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.084715e-07 6.681 0 0
Signal Transduction R-HSA-162582 2.051183e-07 6.688 0 0
Cleavage of the damaged purine R-HSA-110331 2.030031e-07 6.692 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.742259e-07 6.562 0 0
DNA Replication R-HSA-69306 2.742259e-07 6.562 0 0
Depurination R-HSA-73927 2.798693e-07 6.553 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.843433e-07 6.546 0 0
Depyrimidination R-HSA-73928 2.843433e-07 6.546 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.289891e-07 6.483 0 0
Metalloprotease DUBs R-HSA-5689901 3.896783e-07 6.409 0 0
Separation of Sister Chromatids R-HSA-2467813 4.855884e-07 6.314 0 0
RNA Polymerase I Transcription R-HSA-73864 5.993603e-07 6.222 0 0
Influenza Infection R-HSA-168255 6.264201e-07 6.203 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.830591e-07 6.166 0 0
Mitotic Anaphase R-HSA-68882 7.822695e-07 6.107 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.213619e-07 6.085 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.762506e-07 6.057 0 0
Deubiquitination R-HSA-5688426 9.361717e-07 6.029 0 0
Homology Directed Repair R-HSA-5693538 8.897676e-07 6.051 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.878418e-07 6.052 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.403172e-07 6.027 0 0
Adherens junctions interactions R-HSA-418990 9.807050e-07 6.008 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.049751e-06 5.979 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.032139e-06 5.986 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.902042e-07 6.004 0 0
Reproduction R-HSA-1474165 9.907287e-07 6.004 0 0
mRNA Splicing R-HSA-72172 1.063530e-06 5.973 0 0
Protein ubiquitination R-HSA-8852135 1.091768e-06 5.962 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.333263e-06 5.875 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.337886e-06 5.874 0 0
Interleukin-12 signaling R-HSA-9020591 1.337886e-06 5.874 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.619352e-06 5.791 0 0
Ub-specific processing proteases R-HSA-5689880 1.761469e-06 5.754 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.821516e-06 5.740 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.821516e-06 5.740 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.884633e-06 5.725 0 0
HCMV Early Events R-HSA-9609690 2.041071e-06 5.690 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.730809e-06 5.564 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.918829e-06 5.535 0 0
Mitotic Prometaphase R-HSA-68877 3.352558e-06 5.475 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.352820e-06 5.475 0 0
Amyloid fiber formation R-HSA-977225 3.519487e-06 5.454 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.806532e-06 5.419 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.942823e-06 5.404 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.942823e-06 5.404 0 0
DNA Repair R-HSA-73894 4.967057e-06 5.304 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.147613e-06 5.288 0 0
Cell-cell junction organization R-HSA-421270 6.221465e-06 5.206 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 6.223032e-06 5.206 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.196023e-06 5.143 0 0
HCMV Late Events R-HSA-9610379 7.411274e-06 5.130 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.891797e-06 5.103 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.305549e-06 5.081 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.630496e-06 5.016 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.011126e-05 4.995 0 0
Interleukin-12 family signaling R-HSA-447115 1.203086e-05 4.920 0 0
Apoptosis R-HSA-109581 1.337104e-05 4.874 0 0
Diseases of programmed cell death R-HSA-9645723 1.418609e-05 4.848 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.463110e-05 4.835 0 0
ESR-mediated signaling R-HSA-8939211 1.508997e-05 4.821 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.053028e-05 4.688 0 0
Translation initiation complex formation R-HSA-72649 2.177886e-05 4.662 0 0
Telomere Maintenance R-HSA-157579 2.799551e-05 4.553 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.841493e-05 4.546 0 0
Aggrephagy R-HSA-9646399 3.613747e-05 4.442 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.613747e-05 4.442 0 0
Peptide chain elongation R-HSA-156902 4.020394e-05 4.396 0 0
UCH proteinases R-HSA-5689603 4.096643e-05 4.388 0 0
HCMV Infection R-HSA-9609646 4.831375e-05 4.316 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.859647e-05 4.313 0 0
Base Excision Repair R-HSA-73884 5.438442e-05 4.265 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.610859e-05 4.251 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.692883e-05 4.174 0 0
Chromosome Maintenance R-HSA-73886 6.351676e-05 4.197 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.280376e-05 4.138 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.288517e-05 4.137 0 0
Cell-extracellular matrix interactions R-HSA-446353 7.396174e-05 4.131 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.480746e-05 4.126 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.766982e-05 4.110 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.541866e-05 4.068 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.541866e-05 4.068 0 0
HIV Life Cycle R-HSA-162587 8.972947e-05 4.047 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.608635e-05 4.017 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.608635e-05 4.017 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.012003e-04 3.995 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.059060e-04 3.975 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.004200e-04 3.998 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.652276e-05 4.015 0 0
Ribosome-associated quality control R-HSA-9948299 1.180707e-04 3.928 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.241872e-04 3.906 0 0
Regulation of CDH1 Function R-HSA-9764561 1.260983e-04 3.899 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.260983e-04 3.899 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.318947e-04 3.880 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.418657e-04 3.848 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.441598e-04 3.841 0 0
Signaling by WNT R-HSA-195721 1.589736e-04 3.799 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.633215e-04 3.787 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.656810e-04 3.781 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.685006e-04 3.773 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.817932e-04 3.740 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.817932e-04 3.740 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.903957e-04 3.720 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.960790e-04 3.708 0 0
Recycling pathway of L1 R-HSA-437239 1.981642e-04 3.703 1 1
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.143200e-04 3.669 0 0
Programmed Cell Death R-HSA-5357801 2.481004e-04 3.605 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.698184e-04 3.569 0 0
Selective autophagy R-HSA-9663891 2.850167e-04 3.545 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.909539e-04 3.536 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.909539e-04 3.536 0 0
Signaling by NOTCH R-HSA-157118 3.002563e-04 3.523 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.010548e-04 3.521 0 0
RMTs methylate histone arginines R-HSA-3214858 3.613512e-04 3.442 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.637071e-04 3.439 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.637071e-04 3.439 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.730135e-04 3.428 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.837213e-04 3.416 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.212074e-04 3.376 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.212074e-04 3.376 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.262424e-04 3.370 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.339384e-04 3.363 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.897826e-04 3.310 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.003212e-04 3.301 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.950162e-04 3.305 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.003212e-04 3.301 0 0
Host Interactions of HIV factors R-HSA-162909 4.801104e-04 3.319 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.505948e-04 3.346 0 0
Nuclear import of Rev protein R-HSA-180746 4.512800e-04 3.346 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.208914e-04 3.283 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.208914e-04 3.283 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.208914e-04 3.283 0 0
Signaling by RAS mutants R-HSA-6802949 5.208914e-04 3.283 0 0
Nephrin family interactions R-HSA-373753 5.443565e-04 3.264 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.559870e-04 3.255 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.588485e-04 3.181 0 0
Glycolysis R-HSA-70171 6.622243e-04 3.179 0 0
G2/M Transition R-HSA-69275 6.927645e-04 3.159 0 0
HIV Infection R-HSA-162906 7.345636e-04 3.134 0 0
Mitotic G2-G2/M phases R-HSA-453274 8.143509e-04 3.089 0 0
tRNA processing in the nucleus R-HSA-6784531 8.230347e-04 3.085 0 0
Eukaryotic Translation Termination R-HSA-72764 8.707862e-04 3.060 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.778177e-04 3.057 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.778177e-04 3.057 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.157973e-04 3.038 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.515811e-04 3.022 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.011992e-03 2.995 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.011992e-03 2.995 0 0
Signaling by Hippo R-HSA-2028269 1.021737e-03 2.991 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.254450e-03 2.902 0 0
Striated Muscle Contraction R-HSA-390522 1.254450e-03 2.902 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.266136e-03 2.898 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.266136e-03 2.898 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.266136e-03 2.898 0 0
Gene expression (Transcription) R-HSA-74160 1.120263e-03 2.951 0 0
Co-inhibition by PD-1 R-HSA-389948 1.091179e-03 2.962 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.088668e-03 2.963 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.316151e-03 2.881 0 0
Josephin domain DUBs R-HSA-5689877 1.316151e-03 2.881 0 0
Orc1 removal from chromatin R-HSA-68949 1.399325e-03 2.854 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.424369e-03 2.846 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.424369e-03 2.846 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.427143e-03 2.846 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.436099e-03 2.843 0 0
Viral Infection Pathways R-HSA-9824446 1.510308e-03 2.821 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.515707e-03 2.819 0 0
Autophagy R-HSA-9612973 1.528998e-03 2.816 0 0
Late endosomal microautophagy R-HSA-9615710 1.555864e-03 2.808 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.556239e-03 2.808 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.576995e-03 2.802 0 0
Signaling by NOTCH4 R-HSA-9013694 1.619998e-03 2.790 0 0
Selenocysteine synthesis R-HSA-2408557 1.684690e-03 2.773 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.704975e-03 2.768 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.704975e-03 2.768 0 0
Membrane Trafficking R-HSA-199991 1.767550e-03 2.753 0 0
Oncogene Induced Senescence R-HSA-2559585 1.829541e-03 2.738 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.899239e-03 2.721 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.904608e-03 2.720 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.904608e-03 2.720 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.926618e-03 2.715 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.998400e-03 2.699 0 0
Viral mRNA Translation R-HSA-192823 2.071104e-03 2.684 0 0
L1CAM interactions R-HSA-373760 2.165495e-03 2.664 1 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.172974e-03 2.663 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.306500e-03 2.637 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.338461e-03 2.631 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.603211e-03 2.584 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.789480e-03 2.554 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.789480e-03 2.554 0 0
DNA Damage Bypass R-HSA-73893 2.468648e-03 2.608 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.673253e-03 2.573 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.673253e-03 2.573 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.457766e-03 2.609 0 0
Signaling by VEGF R-HSA-194138 2.616746e-03 2.582 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.561925e-03 2.591 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.625184e-03 2.581 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.833162e-03 2.548 0 0
S Phase R-HSA-69242 3.008508e-03 2.522 0 0
rRNA processing R-HSA-72312 3.288068e-03 2.483 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.332935e-03 2.477 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.348571e-03 2.475 0 0
Post NMDA receptor activation events R-HSA-438064 3.459613e-03 2.461 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.500973e-03 2.456 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.500973e-03 2.456 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.570715e-03 2.447 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.621786e-03 2.441 0 0
Metabolism of non-coding RNA R-HSA-194441 3.725660e-03 2.429 0 0
snRNP Assembly R-HSA-191859 3.725660e-03 2.429 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.754182e-03 2.425 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.763151e-03 2.424 0 0
mRNA 3'-end processing R-HSA-72187 3.779310e-03 2.423 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.841713e-03 2.415 0 0
Kinesins R-HSA-983189 4.229450e-03 2.374 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.277774e-03 2.369 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.281116e-03 2.368 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.363073e-03 2.360 0 0
mTORC1-mediated signalling R-HSA-166208 4.422069e-03 2.354 0 0
RAF activation R-HSA-5673000 4.717675e-03 2.326 0 0
Signaling by NOTCH2 R-HSA-1980145 4.717675e-03 2.326 0 0
Glucose metabolism R-HSA-70326 4.843519e-03 2.315 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.878552e-03 2.312 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 4.878552e-03 2.312 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.878552e-03 2.312 0 0
Transport of connexons to the plasma membrane R-HSA-190872 5.412235e-03 2.267 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.722330e-03 2.242 0 0
Activation of the pre-replicative complex R-HSA-68962 6.128773e-03 2.213 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.333876e-03 2.198 0 0
Maturation of protein E R-HSA-9694493 6.333876e-03 2.198 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.333876e-03 2.198 0 0
Maturation of protein E R-HSA-9683683 6.333876e-03 2.198 0 0
TNF signaling R-HSA-75893 6.348067e-03 2.197 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.380932e-03 2.195 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.584266e-03 2.181 0 0
MTOR signalling R-HSA-165159 6.603325e-03 2.180 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.193883e-03 2.087 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.193883e-03 2.087 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.758332e-03 2.170 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.926695e-03 2.101 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.926695e-03 2.101 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 7.256588e-03 2.139 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.554561e-03 2.122 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.404870e-03 2.130 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.978691e-03 2.156 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 8.338289e-03 2.079 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.193883e-03 2.087 0 0
Negative regulation of MET activity R-HSA-6807004 8.338289e-03 2.079 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.295934e-03 2.081 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.193883e-03 2.087 0 0
PKR-mediated signaling R-HSA-9833482 7.404870e-03 2.130 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.759978e-03 2.170 0 0
Developmental Biology R-HSA-1266738 8.586776e-03 2.066 1 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 9.980689e-03 2.001 0 0
Activation of ATR in response to replication stress R-HSA-176187 9.980689e-03 2.001 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.017429e-02 1.992 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.017429e-02 1.992 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.017429e-02 1.992 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.017429e-02 1.992 0 0
Negative regulation of FLT3 R-HSA-9706369 1.034989e-02 1.985 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.034989e-02 1.985 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.055570e-02 1.977 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.062573e-02 1.974 0 0
Macroautophagy R-HSA-1632852 1.076709e-02 1.968 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.132509e-02 1.946 0 0
Cellular response to starvation R-HSA-9711097 1.135955e-02 1.945 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.205792e-02 1.919 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.228824e-02 1.911 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.228824e-02 1.911 0 0
Assembly Of The HIV Virion R-HSA-175474 1.228824e-02 1.911 0 0
Activation of RAC1 R-HSA-428540 1.235024e-02 1.908 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.235024e-02 1.908 0 0
Regulation of TP53 Activity R-HSA-5633007 1.291771e-02 1.889 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.319351e-02 1.880 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.319351e-02 1.880 0 0
Dual Incision in GG-NER R-HSA-5696400 1.341138e-02 1.873 0 0
Regulation of PTEN localization R-HSA-8948747 1.344889e-02 1.871 0 0
Signaling by NOTCH3 R-HSA-9012852 1.349903e-02 1.870 0 0
Synthesis of DNA R-HSA-69239 1.359537e-02 1.867 0 0
Hedgehog 'off' state R-HSA-5610787 1.390803e-02 1.857 0 0
Semaphorin interactions R-HSA-373755 1.400388e-02 1.854 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.438713e-02 1.842 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.470150e-02 1.833 0 0
MAP2K and MAPK activation R-HSA-5674135 1.499944e-02 1.824 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.499944e-02 1.824 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.506789e-02 1.822 0 0
Signaling by EGFR R-HSA-177929 1.506789e-02 1.822 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.572047e-02 1.804 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.581524e-02 1.801 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.586817e-02 1.799 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.586817e-02 1.799 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.586817e-02 1.799 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.586817e-02 1.799 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.586817e-02 1.799 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.608540e-02 1.794 0 0
Degradation of CDH1 R-HSA-9766229 1.608540e-02 1.794 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.727202e-02 1.763 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.743468e-02 1.759 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.743468e-02 1.759 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.764644e-02 1.753 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.789305e-02 1.747 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.836984e-02 1.736 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.836984e-02 1.736 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.836984e-02 1.736 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.836984e-02 1.736 0 0
Regulation of signaling by CBL R-HSA-912631 2.300789e-02 1.638 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.300789e-02 1.638 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.064658e-02 1.685 0 0
Nucleotide Excision Repair R-HSA-5696398 2.206981e-02 1.656 0 0
EGFR downregulation R-HSA-182971 2.064658e-02 1.685 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.226207e-02 1.652 0 0
Translesion Synthesis by POLH R-HSA-110320 2.300789e-02 1.638 0 0
Budding and maturation of HIV virion R-HSA-162588 2.064658e-02 1.685 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.477224e-02 1.606 0 0
Unwinding of DNA R-HSA-176974 2.427819e-02 1.615 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.275345e-02 1.643 0 0
Muscle contraction R-HSA-397014 2.190628e-02 1.659 0 0
Signaling by ERBB2 R-HSA-1227986 2.275345e-02 1.643 0 0
RNA Polymerase II Transcription R-HSA-73857 2.189141e-02 1.660 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.477224e-02 1.606 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.083462e-02 1.681 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.168592e-02 1.664 0 0
Smooth Muscle Contraction R-HSA-445355 2.480343e-02 1.605 0 0
Protein folding R-HSA-391251 2.544575e-02 1.594 0 0
EPH-Ephrin signaling R-HSA-2682334 2.544575e-02 1.594 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.547661e-02 1.594 0 0
Signaling by ALK in cancer R-HSA-9700206 2.547661e-02 1.594 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.571266e-02 1.590 0 0
Death Receptor Signaling R-HSA-73887 2.614951e-02 1.583 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.618458e-02 1.582 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.688500e-02 1.570 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.688500e-02 1.570 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.688500e-02 1.570 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.688500e-02 1.570 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.703046e-02 1.568 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.730225e-02 1.564 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.731455e-02 1.564 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.732212e-02 1.563 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.774377e-02 1.557 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.890230e-02 1.539 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.890230e-02 1.539 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.890230e-02 1.539 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.989648e-02 1.524 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.017826e-02 1.520 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.017826e-02 1.520 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.022324e-02 1.520 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.022324e-02 1.520 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.022324e-02 1.520 0 0
p75NTR signals via NF-kB R-HSA-193639 3.022324e-02 1.520 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.052206e-02 1.515 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.063251e-02 1.514 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.104046e-02 1.508 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.121272e-02 1.506 0 0
Regulation of CDH11 function R-HSA-9762292 3.121272e-02 1.506 0 0
Pexophagy R-HSA-9664873 3.121272e-02 1.506 0 0
TCR signaling R-HSA-202403 3.131193e-02 1.504 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.212277e-02 1.493 0 0
G1/S Transition R-HSA-69206 3.229386e-02 1.491 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.235915e-02 1.490 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.235915e-02 1.490 0 0
FLT3 Signaling R-HSA-9607240 3.235915e-02 1.490 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.506623e-02 1.455 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.609233e-02 1.443 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.654071e-02 1.437 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.662556e-02 1.436 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.667987e-02 1.436 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.744985e-02 1.427 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.744985e-02 1.427 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.845376e-02 1.415 0 0
Regulation of Apoptosis R-HSA-169911 3.898534e-02 1.409 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.898534e-02 1.409 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.920640e-02 1.407 0 0
Dual incision in TC-NER R-HSA-6782135 3.998016e-02 1.398 0 0
Ca-dependent events R-HSA-111996 4.011022e-02 1.397 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.011022e-02 1.397 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.014607e-02 1.396 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.129344e-02 1.384 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.155787e-02 1.381 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.155787e-02 1.381 0 0
Calmodulin induced events R-HSA-111933 4.364747e-02 1.360 0 0
CaM pathway R-HSA-111997 4.364747e-02 1.360 0 0
FLT3 signaling in disease R-HSA-9682385 4.364747e-02 1.360 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.442042e-02 1.352 0 0
Signaling by NOTCH1 R-HSA-1980143 4.460458e-02 1.351 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.611239e-02 1.336 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.754861e-02 1.323 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.754861e-02 1.323 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.754861e-02 1.323 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.754861e-02 1.323 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.754861e-02 1.323 0 0
Integration of provirus R-HSA-162592 4.823854e-02 1.317 0 0
NF-kB is activated and signals survival R-HSA-209560 4.823854e-02 1.317 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.842526e-02 1.315 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.856063e-02 1.314 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.856063e-02 1.314 0 0
Degradation of DVL R-HSA-4641258 4.866263e-02 1.313 0 0
Gap junction trafficking R-HSA-190828 4.902969e-02 1.310 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.118578e-02 1.291 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.118578e-02 1.291 0 0
Diseases of Cellular Senescence R-HSA-9630747 5.118578e-02 1.291 0 0
Diseases of cellular response to stress R-HSA-9675132 5.118578e-02 1.291 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.118578e-02 1.291 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.118578e-02 1.291 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.118578e-02 1.291 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.118578e-02 1.291 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.118578e-02 1.291 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.118578e-02 1.291 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.118578e-02 1.291 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.118578e-02 1.291 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.118578e-02 1.291 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 7.547972e-02 1.122 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.287532e-02 1.202 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.287532e-02 1.202 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.946332e-02 1.158 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.821148e-02 1.166 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.596467e-02 1.181 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.305973e-02 1.275 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.305973e-02 1.275 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.286453e-02 1.202 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.817730e-02 1.166 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.725142e-02 1.172 0 0
Ephrin signaling R-HSA-3928664 5.915711e-02 1.228 0 0
Myogenesis R-HSA-525793 7.224545e-02 1.141 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.596467e-02 1.181 0 0
Frs2-mediated activation R-HSA-170968 6.946332e-02 1.158 0 0
DAG and IP3 signaling R-HSA-1489509 5.394391e-02 1.268 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.915711e-02 1.228 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.782640e-02 1.238 0 0
MAPK family signaling cascades R-HSA-5683057 7.236834e-02 1.140 0 0
Signaling by Hedgehog R-HSA-5358351 7.378304e-02 1.132 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.224545e-02 1.141 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.915711e-02 1.228 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.287532e-02 1.202 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.946332e-02 1.158 0 0
Vpu mediated degradation of CD4 R-HSA-180534 7.317663e-02 1.136 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.288027e-02 1.277 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 5.833324e-02 1.234 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 5.833324e-02 1.234 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.977787e-02 1.223 0 0
Stabilization of p53 R-HSA-69541 5.977787e-02 1.223 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.833324e-02 1.234 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.833324e-02 1.234 0 0
Interferon Signaling R-HSA-913531 6.671847e-02 1.176 0 0
Gap junction trafficking and regulation R-HSA-157858 7.673519e-02 1.115 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.673519e-02 1.115 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.673519e-02 1.115 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.673519e-02 1.115 0 0
Centrosome maturation R-HSA-380287 7.718877e-02 1.112 0 0
PTEN Regulation R-HSA-6807070 7.744377e-02 1.111 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.790154e-02 1.108 0 0
Formation of annular gap junctions R-HSA-196025 7.849920e-02 1.105 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.849920e-02 1.105 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.849920e-02 1.105 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.849920e-02 1.105 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.849920e-02 1.105 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.922442e-02 1.101 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.922442e-02 1.101 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.922442e-02 1.101 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 8.034488e-02 1.095 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.083581e-02 1.092 0 0
Gap junction assembly R-HSA-190861 8.083581e-02 1.092 0 0
Mitophagy R-HSA-5205647 8.083581e-02 1.092 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.083581e-02 1.092 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.083581e-02 1.092 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.083581e-02 1.092 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.083581e-02 1.092 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.086573e-02 1.092 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.086573e-02 1.092 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.086573e-02 1.092 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.146270e-02 1.089 0 0
Regulation of KIT signaling R-HSA-1433559 8.160030e-02 1.088 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 8.160030e-02 1.088 0 0
Vesicle-mediated transport R-HSA-5653656 8.184213e-02 1.087 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.291230e-02 1.081 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.322932e-02 1.080 0 0
Drug resistance of KIT mutants R-HSA-9669937 8.611280e-02 1.065 0 0
KIT mutants bind TKIs R-HSA-9669921 8.611280e-02 1.065 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 8.611280e-02 1.065 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 8.611280e-02 1.065 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 8.611280e-02 1.065 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 8.611280e-02 1.065 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 8.611280e-02 1.065 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 8.611280e-02 1.065 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 8.611280e-02 1.065 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 8.611280e-02 1.065 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 8.611280e-02 1.065 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 8.611280e-02 1.065 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.847609e-02 1.053 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.847609e-02 1.053 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.894018e-02 1.051 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.894018e-02 1.051 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.003426e-02 1.046 0 0
HIV elongation arrest and recovery R-HSA-167287 9.003426e-02 1.046 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.003426e-02 1.046 0 0
Pausing and recovery of HIV elongation R-HSA-167290 9.003426e-02 1.046 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.003426e-02 1.046 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.004358e-02 1.046 0 0
PCP/CE pathway R-HSA-4086400 9.376032e-02 1.028 0 0
Translesion synthesis by REV1 R-HSA-110312 9.470607e-02 1.024 0 0
Protein methylation R-HSA-8876725 9.470607e-02 1.024 0 0
DCC mediated attractive signaling R-HSA-418885 9.470607e-02 1.024 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 9.470607e-02 1.024 0 0
Lipophagy R-HSA-9613354 9.562903e-02 1.019 0 0
Gap junction degradation R-HSA-190873 9.562903e-02 1.019 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 9.562903e-02 1.019 0 0
Calcineurin activates NFAT R-HSA-2025928 9.562903e-02 1.019 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 9.562903e-02 1.019 0 0
Generic Transcription Pathway R-HSA-212436 9.571780e-02 1.019 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.717702e-02 1.012 0 0
Neurexins and neuroligins R-HSA-6794361 9.717702e-02 1.012 0 0
RET signaling R-HSA-8853659 9.748576e-02 1.011 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.748576e-02 1.011 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.965638e-02 1.001 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.965638e-02 1.001 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.965638e-02 1.001 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.968164e-02 1.001 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 9.968164e-02 1.001 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.974248e-02 1.001 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.974248e-02 1.001 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.020229e-01 0.991 0 0
Cyclin D associated events in G1 R-HSA-69231 1.020229e-01 0.991 0 0
G1 Phase R-HSA-69236 1.020229e-01 0.991 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.020229e-01 0.991 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.034896e-01 0.985 0 0
Translation R-HSA-72766 1.041475e-01 0.982 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.046277e-01 0.980 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.046277e-01 0.980 0 0
Selenoamino acid metabolism R-HSA-2408522 1.055237e-01 0.977 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.059062e-01 0.975 0 0
Signaling by MET R-HSA-6806834 1.059239e-01 0.975 0 0
Signaling by FGFR2 R-HSA-5654738 1.059239e-01 0.975 0 0
Hedgehog 'on' state R-HSA-5632684 1.062505e-01 0.974 0 0
Degradation of AXIN R-HSA-4641257 1.064666e-01 0.973 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.064666e-01 0.973 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.064666e-01 0.973 0 0
Translesion synthesis by POLI R-HSA-5656121 1.087343e-01 0.964 0 0
Prolonged ERK activation events R-HSA-169893 1.087343e-01 0.964 0 0
Regulation of BACH1 activity R-HSA-9708530 1.087343e-01 0.964 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.103574e-01 0.957 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.103574e-01 0.957 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.103574e-01 0.957 0 0
FGFR2 alternative splicing R-HSA-6803529 1.115075e-01 0.953 0 0
SARS-CoV Infections R-HSA-9679506 1.128190e-01 0.948 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.131682e-01 0.946 0 0
Signaling by PTK6 R-HSA-8848021 1.131682e-01 0.946 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.131682e-01 0.946 0 0
2-LTR circle formation R-HSA-164843 1.141271e-01 0.943 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.141271e-01 0.943 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.141271e-01 0.943 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.158751e-01 0.936 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.174204e-01 0.930 0 0
Disorders of Developmental Biology R-HSA-9675151 1.236317e-01 0.908 0 0
Translesion synthesis by POLK R-HSA-5655862 1.236317e-01 0.908 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.236317e-01 0.908 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.236317e-01 0.908 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.240143e-01 0.907 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.257015e-01 0.901 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.273683e-01 0.895 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.274252e-01 0.895 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.276670e-01 0.894 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.280981e-01 0.892 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.285525e-01 0.891 0 0
IRS activation R-HSA-74713 1.319549e-01 0.880 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.319549e-01 0.880 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.319549e-01 0.880 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.319784e-01 0.879 0 0
Signaling by WNT in cancer R-HSA-4791275 1.319784e-01 0.879 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.648149e-01 0.783 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.648149e-01 0.783 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.648149e-01 0.783 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.648149e-01 0.783 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.648149e-01 0.783 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.648149e-01 0.783 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.648149e-01 0.783 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.648149e-01 0.783 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.648149e-01 0.783 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.648149e-01 0.783 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.648149e-01 0.783 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.648149e-01 0.783 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.367435e-01 0.626 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.367435e-01 0.626 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.367435e-01 0.626 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.367435e-01 0.626 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.367435e-01 0.626 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.367435e-01 0.626 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.367435e-01 0.626 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.367435e-01 0.626 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.367435e-01 0.626 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.367435e-01 0.626 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.367435e-01 0.626 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.628889e-01 0.788 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.628889e-01 0.788 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.949348e-01 0.710 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.949348e-01 0.710 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.546418e-01 0.811 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.546418e-01 0.811 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.546418e-01 0.811 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.276722e-01 0.643 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.276722e-01 0.643 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.276722e-01 0.643 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.276722e-01 0.643 0 0
SOS-mediated signalling R-HSA-112412 2.276722e-01 0.643 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.763594e-01 0.754 0 0
Disorders of Nervous System Development R-HSA-9697154 1.763594e-01 0.754 0 0
Pervasive developmental disorders R-HSA-9005895 1.763594e-01 0.754 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.763594e-01 0.754 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.763594e-01 0.754 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.763594e-01 0.754 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.763594e-01 0.754 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.763594e-01 0.754 0 0
Type I hemidesmosome assembly R-HSA-446107 2.607446e-01 0.584 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.988531e-01 0.701 0 0
Formation of axial mesoderm R-HSA-9796292 1.988531e-01 0.701 0 0
HDMs demethylate histones R-HSA-3214842 1.508071e-01 0.822 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.456015e-01 0.610 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.456015e-01 0.610 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.089666e-01 0.680 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.558915e-01 0.807 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.689411e-01 0.772 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.663858e-01 0.574 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.663858e-01 0.574 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.519358e-01 0.599 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.306437e-01 0.637 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.553795e-01 0.809 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.968271e-01 0.706 0 0
HIV Transcription Elongation R-HSA-167169 2.519358e-01 0.599 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.650465e-01 0.782 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.519358e-01 0.599 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.557942e-01 0.807 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.620461e-01 0.582 0 0
Generation of second messenger molecules R-HSA-202433 1.359348e-01 0.867 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.372538e-01 0.625 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.807201e-01 0.743 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.807201e-01 0.743 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.676388e-01 0.776 0 0
Trafficking of AMPA receptors R-HSA-399719 2.430608e-01 0.614 0 0
G alpha (12/13) signalling events R-HSA-416482 2.517481e-01 0.599 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.763594e-01 0.754 0 0
Rap1 signalling R-HSA-392517 1.729297e-01 0.762 0 0
Long-term potentiation R-HSA-9620244 1.508071e-01 0.822 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.650465e-01 0.782 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.415605e-01 0.617 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.628889e-01 0.788 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.266869e-01 0.645 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.050695e-01 0.688 0 0
Cellular response to hypoxia R-HSA-1234174 2.168178e-01 0.664 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.949225e-01 0.710 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.562392e-01 0.806 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.954876e-01 0.709 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.360883e-01 0.866 0 0
DNA strand elongation R-HSA-69190 2.597350e-01 0.585 0 0
Circadian clock R-HSA-9909396 2.652734e-01 0.576 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.087382e-01 0.680 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.714412e-01 0.766 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.729297e-01 0.762 0 0
Platelet degranulation R-HSA-114608 2.169781e-01 0.664 0 0
PLC beta mediated events R-HSA-112043 1.751082e-01 0.757 0 0
Ion transport by P-type ATPases R-HSA-936837 2.060395e-01 0.686 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.367435e-01 0.626 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.367435e-01 0.626 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.367435e-01 0.626 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.367435e-01 0.626 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.628889e-01 0.788 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.685125e-01 0.773 0 0
Intraflagellar transport R-HSA-5620924 1.374899e-01 0.862 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.611345e-01 0.583 0 0
Interleukin-1 signaling R-HSA-9020702 1.410560e-01 0.851 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.927367e-01 0.715 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.902586e-01 0.721 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.437059e-01 0.843 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.892697e-01 0.723 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.685125e-01 0.773 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.120037e-01 0.674 0 0
G-protein mediated events R-HSA-112040 2.390050e-01 0.622 0 0
Nef and signal transduction R-HSA-164944 1.949348e-01 0.710 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.676388e-01 0.776 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.106562e-01 0.676 0 0
Cilium Assembly R-HSA-5617833 1.934584e-01 0.713 0 0
TGFBR3 expression R-HSA-9839394 1.508071e-01 0.822 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.620461e-01 0.582 0 0
Signaling by FGFR4 R-HSA-5654743 1.806603e-01 0.743 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.367435e-01 0.626 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.367435e-01 0.626 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.949348e-01 0.710 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.763594e-01 0.754 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.465622e-01 0.834 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.597350e-01 0.585 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.237479e-01 0.650 0 0
Signaling by FGFR1 R-HSA-5654736 2.237479e-01 0.650 0 0
Signaling by FGFR3 R-HSA-5654741 2.050695e-01 0.688 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.266869e-01 0.645 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.806603e-01 0.743 0 0
Signaling by FGFR R-HSA-190236 1.905586e-01 0.720 0 0
Formation of definitive endoderm R-HSA-9823730 1.906772e-01 0.720 0 0
Signaling by TGFBR3 R-HSA-9839373 2.177210e-01 0.662 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.060395e-01 0.686 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.807201e-01 0.743 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.949348e-01 0.710 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.468905e-01 0.607 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.050695e-01 0.688 0 0
NRAGE signals death through JNK R-HSA-193648 2.237479e-01 0.650 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.349641e-01 0.870 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.430608e-01 0.614 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 1.797945e-01 0.745 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.465622e-01 0.834 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.050695e-01 0.688 0 0
Specification of primordial germ cells R-HSA-9827857 1.393394e-01 0.856 0 0
Co-stimulation by CD28 R-HSA-389356 2.438165e-01 0.613 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.276722e-01 0.643 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.456015e-01 0.610 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.456015e-01 0.610 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.553795e-01 0.809 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.885610e-01 0.725 0 0
Signaling by Interleukins R-HSA-449147 1.967471e-01 0.706 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.557942e-01 0.807 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.089666e-01 0.680 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.988531e-01 0.701 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.806603e-01 0.743 0 0
Inositol phosphate metabolism R-HSA-1483249 2.335929e-01 0.632 0 0
MHC class II antigen presentation R-HSA-2132295 1.800327e-01 0.745 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.089666e-01 0.680 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.106562e-01 0.676 0 0
Translation of Structural Proteins R-HSA-9683701 1.575694e-01 0.803 0 0
IRE1alpha activates chaperones R-HSA-381070 2.056683e-01 0.687 0 0
Glycogen metabolism R-HSA-8982491 2.519358e-01 0.599 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.421837e-01 0.616 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.237479e-01 0.650 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.277277e-01 0.643 0 0
Glycogen storage diseases R-HSA-3229121 1.393394e-01 0.856 0 0
Glycogen synthesis R-HSA-3322077 1.906772e-01 0.720 0 0
Phosphorylation of the APC/C R-HSA-176412 2.695885e-01 0.569 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.695885e-01 0.569 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.695885e-01 0.569 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.695885e-01 0.569 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.695885e-01 0.569 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.719302e-01 0.566 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.736717e-01 0.563 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.766667e-01 0.558 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.766667e-01 0.558 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.766667e-01 0.558 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.766667e-01 0.558 0 0
MAP kinase activation R-HSA-450294 2.856064e-01 0.544 0 0
Deadenylation of mRNA R-HSA-429947 2.861462e-01 0.543 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.861462e-01 0.543 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.938183e-01 0.532 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.938183e-01 0.532 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.938183e-01 0.532 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.938183e-01 0.532 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.938183e-01 0.532 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.938518e-01 0.532 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.938518e-01 0.532 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.938518e-01 0.532 0 0
ARMS-mediated activation R-HSA-170984 2.938518e-01 0.532 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 2.938518e-01 0.532 0 0
Cellular response to mitochondrial stress R-HSA-9840373 2.938518e-01 0.532 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.938518e-01 0.532 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 2.938518e-01 0.532 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.975509e-01 0.526 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.985780e-01 0.525 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.024814e-01 0.519 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.024814e-01 0.519 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.024814e-01 0.519 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.024814e-01 0.519 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.024814e-01 0.519 0 0
Interleukin-33 signaling R-HSA-9014843 3.024814e-01 0.519 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.024814e-01 0.519 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.024814e-01 0.519 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.092981e-01 0.510 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.092981e-01 0.510 0 0
Signaling by SCF-KIT R-HSA-1433557 3.128028e-01 0.505 0 0
TBC/RABGAPs R-HSA-8854214 3.128028e-01 0.505 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.181767e-01 0.497 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.181767e-01 0.497 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.181767e-01 0.497 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.262028e-01 0.487 0 0
Binding and entry of HIV virion R-HSA-173107 3.267427e-01 0.486 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.267427e-01 0.486 0 0
PI3K/AKT activation R-HSA-198203 3.267427e-01 0.486 0 0
Signal attenuation R-HSA-74749 3.267427e-01 0.486 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.267427e-01 0.486 0 0
Signaling by Leptin R-HSA-2586552 3.267427e-01 0.486 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.284070e-01 0.484 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.285856e-01 0.483 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.421861e-01 0.466 0 0
GAB1 signalosome R-HSA-180292 3.425585e-01 0.465 0 0
Polo-like kinase mediated events R-HSA-156711 3.425585e-01 0.465 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.425585e-01 0.465 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.425585e-01 0.465 0 0
Opioid Signalling R-HSA-111885 3.439851e-01 0.463 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.441082e-01 0.463 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.461301e-01 0.461 0 0
RNA Polymerase III Transcription R-HSA-74158 3.461301e-01 0.461 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.463757e-01 0.460 0 0
Cristae formation R-HSA-8949613 3.463757e-01 0.460 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.463757e-01 0.460 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.463757e-01 0.460 0 0
Ion homeostasis R-HSA-5578775 3.555985e-01 0.449 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.592092e-01 0.445 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.592092e-01 0.445 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.592092e-01 0.445 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.592092e-01 0.445 0 0
Signaling by APC mutants R-HSA-4839744 3.592092e-01 0.445 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.592092e-01 0.445 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.625609e-01 0.441 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.625609e-01 0.441 0 0
MET activates PTPN11 R-HSA-8865999 3.625609e-01 0.441 0 0
Defective ABCC2 causes DJS R-HSA-5679001 3.625609e-01 0.441 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.625609e-01 0.441 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.625609e-01 0.441 0 0
Invadopodia formation R-HSA-8941237 3.625609e-01 0.441 0 0
MET interacts with TNS proteins R-HSA-8875513 3.625609e-01 0.441 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.625609e-01 0.441 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.665676e-01 0.436 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.668671e-01 0.435 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.668671e-01 0.435 0 0
The NLRP3 inflammasome R-HSA-844456 3.668671e-01 0.435 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.668671e-01 0.435 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.697587e-01 0.432 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.700435e-01 0.432 0 0
ABC transporter disorders R-HSA-5619084 3.716582e-01 0.430 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.756897e-01 0.425 0 0
Transcription of the HIV genome R-HSA-167172 3.779174e-01 0.423 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.779174e-01 0.423 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.813429e-01 0.419 0 0
MET promotes cell motility R-HSA-8875878 3.813429e-01 0.419 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.867244e-01 0.413 0 0
mRNA Capping R-HSA-72086 3.867244e-01 0.413 0 0
ER-Phagosome pathway R-HSA-1236974 3.894034e-01 0.410 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.910151e-01 0.408 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.910151e-01 0.408 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.910151e-01 0.408 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.910151e-01 0.408 0 0
Signal transduction by L1 R-HSA-445144 3.910151e-01 0.408 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.910151e-01 0.408 0 0
Protein hydroxylation R-HSA-9629569 3.910151e-01 0.408 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.910805e-01 0.408 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.910805e-01 0.408 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.910805e-01 0.408 0 0
Signaling by AXIN mutants R-HSA-4839735 3.910805e-01 0.408 0 0
Gluconeogenesis R-HSA-70263 3.915159e-01 0.407 0 0
NGF-stimulated transcription R-HSA-9031628 3.915159e-01 0.407 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.915159e-01 0.407 0 0
Adaptive Immune System R-HSA-1280218 3.936208e-01 0.405 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.937418e-01 0.405 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.937418e-01 0.405 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.937418e-01 0.405 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.974330e-01 0.401 0 0
RAS processing R-HSA-9648002 3.989384e-01 0.399 0 0
Peroxisomal protein import R-HSA-9033241 3.990145e-01 0.399 0 0
Downstream TCR signaling R-HSA-202424 4.012914e-01 0.397 0 0
Interleukin-17 signaling R-HSA-448424 4.048013e-01 0.393 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.067954e-01 0.391 0 0
Activation of BH3-only proteins R-HSA-114452 4.067954e-01 0.391 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.082109e-01 0.389 0 0
Basigin interactions R-HSA-210991 4.149234e-01 0.382 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.153990e-01 0.382 0 0
ABC-family proteins mediated transport R-HSA-382556 4.163360e-01 0.381 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.164807e-01 0.380 0 0
Regulation of gap junction activity R-HSA-191650 4.174689e-01 0.379 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.174689e-01 0.379 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.174689e-01 0.379 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.174689e-01 0.379 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.174689e-01 0.379 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.174689e-01 0.379 0 0
GABA synthesis R-HSA-888568 4.174689e-01 0.379 0 0
NADE modulates death signalling R-HSA-205025 4.174689e-01 0.379 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.174689e-01 0.379 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.174689e-01 0.379 0 0
Dopamine receptors R-HSA-390651 4.174689e-01 0.379 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.182463e-01 0.379 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.222184e-01 0.374 0 0
Repression of WNT target genes R-HSA-4641265 4.222184e-01 0.374 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.222184e-01 0.374 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.222184e-01 0.374 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 4.222184e-01 0.374 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.222184e-01 0.374 0 0
OAS antiviral response R-HSA-8983711 4.222184e-01 0.374 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.267333e-01 0.370 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.279612e-01 0.369 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.327509e-01 0.364 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.339375e-01 0.363 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.339375e-01 0.363 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.346053e-01 0.362 0 0
Signaling by TGFB family members R-HSA-9006936 4.368370e-01 0.360 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.385214e-01 0.358 0 0
Ca2+ pathway R-HSA-4086398 4.450658e-01 0.352 0 0
G0 and Early G1 R-HSA-1538133 4.464943e-01 0.350 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.512784e-01 0.346 0 0
HIV Transcription Initiation R-HSA-167161 4.512784e-01 0.346 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.512784e-01 0.346 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.512784e-01 0.346 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.513426e-01 0.345 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.525129e-01 0.344 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.525129e-01 0.344 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.525129e-01 0.344 0 0
Maturation of nucleoprotein R-HSA-9683610 4.525129e-01 0.344 0 0
Signaling by FGFR in disease R-HSA-1226099 4.584109e-01 0.339 0 0
Signaling by ERBB4 R-HSA-1236394 4.584109e-01 0.339 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.614674e-01 0.336 0 0
LDL clearance R-HSA-8964038 4.617469e-01 0.336 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.617469e-01 0.336 0 0
Interleukin-1 family signaling R-HSA-446652 4.635641e-01 0.334 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.660382e-01 0.332 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.660382e-01 0.332 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.676501e-01 0.330 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 4.676501e-01 0.330 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.676501e-01 0.330 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.676501e-01 0.330 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.676501e-01 0.330 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.676501e-01 0.330 0 0
Reelin signalling pathway R-HSA-8866376 4.676501e-01 0.330 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.676501e-01 0.330 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.676501e-01 0.330 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.676501e-01 0.330 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.676501e-01 0.330 0 0
Interleukin-36 pathway R-HSA-9014826 4.676501e-01 0.330 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.676501e-01 0.330 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.676501e-01 0.330 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 4.676501e-01 0.330 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.684748e-01 0.329 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.724795e-01 0.326 0 0
RSV-host interactions R-HSA-9833110 4.726863e-01 0.325 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.818782e-01 0.317 0 0
Zinc transporters R-HSA-435354 4.818782e-01 0.317 0 0
Infectious disease R-HSA-5663205 4.839088e-01 0.315 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.845451e-01 0.315 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.845451e-01 0.315 0 0
Syndecan interactions R-HSA-3000170 4.845451e-01 0.315 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.853281e-01 0.314 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.854999e-01 0.314 0 0
Developmental Cell Lineages R-HSA-9734767 4.857538e-01 0.314 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.967296e-01 0.304 0 0
Translation of Structural Proteins R-HSA-9694635 4.980229e-01 0.303 0 0
Proteasome assembly R-HSA-9907900 5.023290e-01 0.299 0 0
Netrin-1 signaling R-HSA-373752 5.023290e-01 0.299 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.043305e-01 0.297 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.043305e-01 0.297 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.043305e-01 0.297 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.068687e-01 0.295 0 0
Erythropoietin activates RAS R-HSA-9027284 5.102498e-01 0.292 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.102498e-01 0.292 0 0
DNA Damage Reversal R-HSA-73942 5.102498e-01 0.292 0 0
Plus-strand DNA synthesis R-HSA-164525 5.135113e-01 0.289 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.135113e-01 0.289 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.135113e-01 0.289 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.135113e-01 0.289 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.135113e-01 0.289 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.135113e-01 0.289 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.135113e-01 0.289 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.135113e-01 0.289 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.135113e-01 0.289 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.135113e-01 0.289 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.135113e-01 0.289 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.157792e-01 0.288 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.170564e-01 0.286 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.189391e-01 0.285 0 0
PERK regulates gene expression R-HSA-381042 5.230156e-01 0.281 0 0
Signalling to ERKs R-HSA-187687 5.230156e-01 0.281 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.236874e-01 0.281 0 0
Sensory processing of sound R-HSA-9659379 5.239512e-01 0.281 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.257239e-01 0.279 0 0
Regulated Necrosis R-HSA-5218859 5.270146e-01 0.278 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.286773e-01 0.277 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.286773e-01 0.277 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.286773e-01 0.277 0 0
Formation of the nephric duct R-HSA-9830364 5.286773e-01 0.277 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 5.286773e-01 0.277 0 0
Interleukin-7 signaling R-HSA-1266695 5.286773e-01 0.277 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.294667e-01 0.276 0 0
Disorders of transmembrane transporters R-HSA-5619115 5.312707e-01 0.275 0 0
Diseases of DNA repair R-HSA-9675135 5.353093e-01 0.271 0 0
Regulation of pyruvate metabolism R-HSA-9861718 5.353093e-01 0.271 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.361225e-01 0.271 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.361225e-01 0.271 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.367364e-01 0.270 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.375808e-01 0.270 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.375808e-01 0.270 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.375808e-01 0.270 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.375808e-01 0.270 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.375808e-01 0.270 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.375808e-01 0.270 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.375808e-01 0.270 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.375808e-01 0.270 0 0
RUNX2 regulates bone development R-HSA-8941326 5.413564e-01 0.267 0 0
G1/S-Specific Transcription R-HSA-69205 5.413564e-01 0.267 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.433149e-01 0.265 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.499367e-01 0.260 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.499367e-01 0.260 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 5.499367e-01 0.260 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.514203e-01 0.259 0 0
Signaling by LTK in cancer R-HSA-9842640 5.554241e-01 0.255 0 0
STAT5 Activation R-HSA-9645135 5.554241e-01 0.255 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.554241e-01 0.255 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.554241e-01 0.255 0 0
Uncoating of the HIV Virion R-HSA-162585 5.554241e-01 0.255 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.554241e-01 0.255 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 5.554241e-01 0.255 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 5.554241e-01 0.255 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 5.554241e-01 0.255 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.554241e-01 0.255 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.554241e-01 0.255 0 0
Lactose synthesis R-HSA-5653890 5.554241e-01 0.255 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.554241e-01 0.255 0 0
HDL clearance R-HSA-8964011 5.554241e-01 0.255 0 0
CREB3 factors activate genes R-HSA-8874211 5.554241e-01 0.255 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.554241e-01 0.255 0 0
Neurofascin interactions R-HSA-447043 5.554241e-01 0.255 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.599563e-01 0.252 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.600519e-01 0.252 0 0
Adipogenesis R-HSA-9843745 5.632733e-01 0.249 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.636528e-01 0.249 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.638401e-01 0.249 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.638401e-01 0.249 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.638401e-01 0.249 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.638401e-01 0.249 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.668393e-01 0.247 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.668393e-01 0.247 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.706190e-01 0.244 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.706190e-01 0.244 0 0
Neutrophil degranulation R-HSA-6798695 5.852999e-01 0.233 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.890095e-01 0.230 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.890095e-01 0.230 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.890095e-01 0.230 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.907016e-01 0.229 0 0
Inflammasomes R-HSA-622312 5.907016e-01 0.229 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 5.937283e-01 0.226 0 0
TRIF-mediated programmed cell death R-HSA-2562578 5.937283e-01 0.226 0 0
Recycling of eIF2:GDP R-HSA-72731 5.937283e-01 0.226 0 0
Disinhibition of SNARE formation R-HSA-114516 5.937283e-01 0.226 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 5.937283e-01 0.226 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.937283e-01 0.226 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.937283e-01 0.226 0 0
VLDL clearance R-HSA-8964046 5.937283e-01 0.226 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 5.937283e-01 0.226 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 5.937283e-01 0.226 0 0
CHL1 interactions R-HSA-447041 5.937283e-01 0.226 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.937283e-01 0.226 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.940921e-01 0.226 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.940921e-01 0.226 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.940921e-01 0.226 0 0
Cellular response to chemical stress R-HSA-9711123 6.003582e-01 0.222 0 0
Signaling by Erythropoietin R-HSA-9006335 6.101670e-01 0.215 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.101670e-01 0.215 0 0
DARPP-32 events R-HSA-180024 6.101670e-01 0.215 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.108491e-01 0.214 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.108491e-01 0.214 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.108491e-01 0.214 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.130818e-01 0.212 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.130818e-01 0.212 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.130818e-01 0.212 0 0
Mismatch Repair R-HSA-5358508 6.130818e-01 0.212 0 0
Platelet sensitization by LDL R-HSA-432142 6.130818e-01 0.212 0 0
Apoptotic factor-mediated response R-HSA-111471 6.130818e-01 0.212 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.252617e-01 0.204 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.275431e-01 0.202 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.287342e-01 0.202 0 0
Minus-strand DNA synthesis R-HSA-164516 6.287342e-01 0.202 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 6.287342e-01 0.202 0 0
phospho-PLA2 pathway R-HSA-111995 6.287342e-01 0.202 0 0
MET receptor recycling R-HSA-8875656 6.287342e-01 0.202 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.287342e-01 0.202 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.287342e-01 0.202 0 0
Regulation by c-FLIP R-HSA-3371378 6.287342e-01 0.202 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.287342e-01 0.202 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.287342e-01 0.202 0 0
Dimerization of procaspase-8 R-HSA-69416 6.287342e-01 0.202 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.287342e-01 0.202 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.287342e-01 0.202 0 0
Adrenoceptors R-HSA-390696 6.287342e-01 0.202 0 0
Sodium/Proton exchangers R-HSA-425986 6.287342e-01 0.202 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.290025e-01 0.201 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.290025e-01 0.201 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.290025e-01 0.201 0 0
tRNA processing R-HSA-72306 6.313060e-01 0.200 0 0
Rab regulation of trafficking R-HSA-9007101 6.318151e-01 0.199 0 0
Signaling by NTRKs R-HSA-166520 6.327202e-01 0.199 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.360591e-01 0.197 0 0
Maturation of nucleoprotein R-HSA-9694631 6.360591e-01 0.197 0 0
Downstream signal transduction R-HSA-186763 6.471993e-01 0.189 0 0
Potential therapeutics for SARS R-HSA-9679191 6.499273e-01 0.187 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.511156e-01 0.186 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.579515e-01 0.182 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.579515e-01 0.182 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.579515e-01 0.182 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.607259e-01 0.180 0 0
WNT mediated activation of DVL R-HSA-201688 6.607259e-01 0.180 0 0
CASP8 activity is inhibited R-HSA-5218900 6.607259e-01 0.180 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.607259e-01 0.180 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.607259e-01 0.180 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.607259e-01 0.180 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.607259e-01 0.180 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.607259e-01 0.180 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.607259e-01 0.180 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.607259e-01 0.180 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 6.607259e-01 0.180 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.607259e-01 0.180 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.607259e-01 0.180 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.607259e-01 0.180 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.633146e-01 0.178 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.647527e-01 0.177 0 0
G alpha (z) signalling events R-HSA-418597 6.692608e-01 0.174 0 0
Protein localization R-HSA-9609507 6.749206e-01 0.171 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.787753e-01 0.168 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 6.787753e-01 0.168 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.816612e-01 0.166 0 0
Ion channel transport R-HSA-983712 6.880556e-01 0.162 0 0
MAPK3 (ERK1) activation R-HSA-110056 6.899625e-01 0.161 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.899625e-01 0.161 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.899625e-01 0.161 0 0
DNA replication initiation R-HSA-68952 6.899625e-01 0.161 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.899625e-01 0.161 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.899625e-01 0.161 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.899625e-01 0.161 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.899625e-01 0.161 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 6.899625e-01 0.161 0 0
Maturation of spike protein R-HSA-9683686 6.899625e-01 0.161 0 0
Tandem pore domain potassium channels R-HSA-1296346 6.899625e-01 0.161 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.899625e-01 0.161 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 6.899625e-01 0.161 0 0
SLC transporter disorders R-HSA-5619102 6.923408e-01 0.160 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.979265e-01 0.156 0 0
Acyl chain remodelling of PC R-HSA-1482788 6.979265e-01 0.156 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.979265e-01 0.156 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.980570e-01 0.156 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 6.980570e-01 0.156 0 0
Ribavirin ADME R-HSA-9755088 6.985521e-01 0.156 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.985521e-01 0.156 0 0
Neuronal System R-HSA-112316 6.996637e-01 0.155 0 0
Somitogenesis R-HSA-9824272 7.020099e-01 0.154 0 0
Toll-like Receptor Cascades R-HSA-168898 7.024251e-01 0.153 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.077846e-01 0.150 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.135528e-01 0.147 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.142512e-01 0.146 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.166813e-01 0.145 0 0
LGI-ADAM interactions R-HSA-5682910 7.166813e-01 0.145 0 0
vRNA Synthesis R-HSA-192814 7.166813e-01 0.145 0 0
vRNP Assembly R-HSA-192905 7.166813e-01 0.145 0 0
Synthesis of PI R-HSA-1483226 7.166813e-01 0.145 0 0
Propionyl-CoA catabolism R-HSA-71032 7.166813e-01 0.145 0 0
Bicarbonate transporters R-HSA-425381 7.166813e-01 0.145 0 0
Suppression of apoptosis R-HSA-9635465 7.166813e-01 0.145 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.166813e-01 0.145 0 0
Interleukin-2 signaling R-HSA-9020558 7.166813e-01 0.145 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.166813e-01 0.145 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.173076e-01 0.144 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.173076e-01 0.144 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.216666e-01 0.142 0 0
Transmission across Chemical Synapses R-HSA-112315 7.249430e-01 0.140 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.251988e-01 0.140 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.285470e-01 0.138 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.350710e-01 0.134 0 0
Growth hormone receptor signaling R-HSA-982772 7.350710e-01 0.134 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.410990e-01 0.130 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.410990e-01 0.130 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.410990e-01 0.130 0 0
Plasmalogen biosynthesis R-HSA-75896 7.410990e-01 0.130 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 7.410990e-01 0.130 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.410990e-01 0.130 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.410990e-01 0.130 0 0
FGFR2 mutant receptor activation R-HSA-1839126 7.429177e-01 0.129 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.430500e-01 0.129 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.430500e-01 0.129 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.518738e-01 0.124 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.518738e-01 0.124 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.518738e-01 0.124 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 7.518738e-01 0.124 0 0
Neurodegenerative Diseases R-HSA-8863678 7.518738e-01 0.124 0 0
Heme signaling R-HSA-9707616 7.540824e-01 0.123 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.566756e-01 0.121 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.580085e-01 0.120 0 0
Pyruvate metabolism R-HSA-70268 7.596878e-01 0.119 0 0
Maple Syrup Urine Disease R-HSA-9865114 7.634135e-01 0.117 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.634135e-01 0.117 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.634135e-01 0.117 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.634135e-01 0.117 0 0
Signaling by LTK R-HSA-9842663 7.634135e-01 0.117 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.634135e-01 0.117 0 0
Regulation of IFNG signaling R-HSA-877312 7.634135e-01 0.117 0 0
Leading Strand Synthesis R-HSA-69109 7.634135e-01 0.117 0 0
Polymerase switching R-HSA-69091 7.634135e-01 0.117 0 0
Estrogen biosynthesis R-HSA-193144 7.634135e-01 0.117 0 0
Interleukin-15 signaling R-HSA-8983432 7.634135e-01 0.117 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.647569e-01 0.116 0 0
Azathioprine ADME R-HSA-9748787 7.653593e-01 0.116 0 0
PI3K Cascade R-HSA-109704 7.653593e-01 0.116 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.653593e-01 0.116 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.677498e-01 0.115 0 0
Tight junction interactions R-HSA-420029 7.677498e-01 0.115 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.677498e-01 0.115 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.677498e-01 0.115 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.698328e-01 0.114 0 0
IGF1R signaling cascade R-HSA-2428924 7.750767e-01 0.111 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.800753e-01 0.108 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.824028e-01 0.107 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 7.827337e-01 0.106 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.827337e-01 0.106 0 0
Urea cycle R-HSA-70635 7.827337e-01 0.106 0 0
Processing of SMDT1 R-HSA-8949664 7.838060e-01 0.106 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 7.838060e-01 0.106 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.838060e-01 0.106 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 7.838060e-01 0.106 0 0
FGFR1c ligand binding and activation R-HSA-190373 7.838060e-01 0.106 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.838060e-01 0.106 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 7.838060e-01 0.106 0 0
Interleukin-6 signaling R-HSA-1059683 7.838060e-01 0.106 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.838060e-01 0.106 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.850458e-01 0.105 0 0
Interleukin-2 family signaling R-HSA-451927 7.944001e-01 0.100 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.968614e-01 0.099 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.968614e-01 0.099 0 0
Removal of the Flap Intermediate R-HSA-69166 8.024419e-01 0.096 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.024419e-01 0.096 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.024419e-01 0.096 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.024419e-01 0.096 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.024419e-01 0.096 0 0
Hydrolysis of LPC R-HSA-1483115 8.024419e-01 0.096 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.024419e-01 0.096 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 8.024419e-01 0.096 0 0
Physiological factors R-HSA-5578768 8.024419e-01 0.096 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.024419e-01 0.096 0 0
Malate-aspartate shuttle R-HSA-9856872 8.024419e-01 0.096 0 0
Signal regulatory protein family interactions R-HSA-391160 8.024419e-01 0.096 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.024419e-01 0.096 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.024419e-01 0.096 0 0
Telomere Extension By Telomerase R-HSA-171319 8.101691e-01 0.091 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.101691e-01 0.091 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.124573e-01 0.090 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.167390e-01 0.088 0 0
Neddylation R-HSA-8951664 8.168999e-01 0.088 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.194724e-01 0.086 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.194724e-01 0.086 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.194724e-01 0.086 0 0
Biotin transport and metabolism R-HSA-196780 8.194724e-01 0.086 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.194724e-01 0.086 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.215134e-01 0.085 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.271136e-01 0.082 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.344698e-01 0.079 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.344698e-01 0.079 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.344698e-01 0.079 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.344698e-01 0.079 0 0
Interleukin-37 signaling R-HSA-9008059 8.344698e-01 0.079 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.350357e-01 0.078 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.350357e-01 0.078 0 0
Killing mechanisms R-HSA-9664420 8.350357e-01 0.078 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.350357e-01 0.078 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.350357e-01 0.078 0 0
Activation of SMO R-HSA-5635838 8.350357e-01 0.078 0 0
Attachment and Entry R-HSA-9678110 8.350357e-01 0.078 0 0
Atorvastatin ADME R-HSA-9754706 8.350357e-01 0.078 0 0
Virus Assembly and Release R-HSA-168268 8.350357e-01 0.078 0 0
IRS-mediated signalling R-HSA-112399 8.357368e-01 0.078 0 0
Stimuli-sensing channels R-HSA-2672351 8.447784e-01 0.073 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.455348e-01 0.073 0 0
Amine ligand-binding receptors R-HSA-375280 8.463582e-01 0.072 0 0
Phase 2 - plateau phase R-HSA-5576893 8.492581e-01 0.071 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.492581e-01 0.071 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.492581e-01 0.071 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.492581e-01 0.071 0 0
Passive transport by Aquaporins R-HSA-432047 8.492581e-01 0.071 0 0
Synthesis of PG R-HSA-1483148 8.492581e-01 0.071 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.492581e-01 0.071 0 0
Coenzyme A biosynthesis R-HSA-196783 8.492581e-01 0.071 0 0
Cardiac conduction R-HSA-5576891 8.504476e-01 0.070 0 0
Immune System R-HSA-168256 8.510306e-01 0.070 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.519186e-01 0.070 0 0
Extension of Telomeres R-HSA-180786 8.522744e-01 0.069 0 0
Regulation of beta-cell development R-HSA-186712 8.522744e-01 0.069 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.552632e-01 0.068 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.559231e-01 0.068 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.599997e-01 0.066 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.613459e-01 0.065 0 0
Hemostasis R-HSA-109582 8.614291e-01 0.065 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.622551e-01 0.064 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.622551e-01 0.064 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.622551e-01 0.064 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.622551e-01 0.064 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.622551e-01 0.064 0 0
Sulfide oxidation to sulfate R-HSA-1614517 8.622551e-01 0.064 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.622551e-01 0.064 0 0
Choline catabolism R-HSA-6798163 8.622551e-01 0.064 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.622551e-01 0.064 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.622551e-01 0.064 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.637135e-01 0.064 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.637135e-01 0.064 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.637135e-01 0.064 0 0
Post-translational protein modification R-HSA-597592 8.643805e-01 0.063 0 0
FOXO-mediated transcription R-HSA-9614085 8.646279e-01 0.063 0 0
Integrin signaling R-HSA-354192 8.656693e-01 0.063 0 0
G-protein beta:gamma signalling R-HSA-397795 8.656693e-01 0.063 0 0
Nuclear RNA decay R-HSA-9930044 8.656693e-01 0.063 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.656693e-01 0.063 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.741322e-01 0.058 0 0
PKA activation R-HSA-163615 8.741322e-01 0.058 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.741322e-01 0.058 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.741322e-01 0.058 0 0
PKA activation in glucagon signalling R-HSA-164378 8.741322e-01 0.058 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.741322e-01 0.058 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.741322e-01 0.058 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.741322e-01 0.058 0 0
Mitochondrial protein import R-HSA-1268020 8.744182e-01 0.058 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.744182e-01 0.058 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.744182e-01 0.058 0 0
Signaling by PDGF R-HSA-186797 8.744182e-01 0.058 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.748067e-01 0.058 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.748067e-01 0.058 0 0
Heme degradation R-HSA-189483 8.748067e-01 0.058 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.748067e-01 0.058 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.781797e-01 0.056 0 0
Metal ion SLC transporters R-HSA-425410 8.793200e-01 0.056 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.794151e-01 0.056 0 0
eNOS activation R-HSA-203615 8.833680e-01 0.054 0 0
Signal amplification R-HSA-392518 8.833680e-01 0.054 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.833680e-01 0.054 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.849858e-01 0.053 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.849858e-01 0.053 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.849858e-01 0.053 0 0
Specification of the neural plate border R-HSA-9834899 8.849858e-01 0.053 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.849858e-01 0.053 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.849858e-01 0.053 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.849858e-01 0.053 0 0
Insulin receptor signalling cascade R-HSA-74751 8.875348e-01 0.052 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.911021e-01 0.050 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.913843e-01 0.050 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.949042e-01 0.048 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.949042e-01 0.048 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.949042e-01 0.048 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 8.949042e-01 0.048 0 0
Signaling by NODAL R-HSA-1181150 8.949042e-01 0.048 0 0
Creatine metabolism R-HSA-71288 8.949042e-01 0.048 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.949042e-01 0.048 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.949042e-01 0.048 0 0
Leishmania phagocytosis R-HSA-9664417 8.980661e-01 0.047 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.980661e-01 0.047 0 0
Parasite infection R-HSA-9664407 8.980661e-01 0.047 0 0
Glycosphingolipid transport R-HSA-9845576 8.988862e-01 0.046 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.988862e-01 0.046 0 0
Triglyceride catabolism R-HSA-163560 8.988862e-01 0.046 0 0
The phototransduction cascade R-HSA-2514856 8.997535e-01 0.046 0 0
Mitochondrial biogenesis R-HSA-1592230 9.021233e-01 0.045 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.038217e-01 0.044 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.039677e-01 0.044 0 0
G-protein activation R-HSA-202040 9.039677e-01 0.044 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.039677e-01 0.044 0 0
Lagging Strand Synthesis R-HSA-69186 9.039677e-01 0.044 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.039677e-01 0.044 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.039677e-01 0.044 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.039677e-01 0.044 0 0
NCAM1 interactions R-HSA-419037 9.059025e-01 0.043 0 0
PPARA activates gene expression R-HSA-1989781 9.082217e-01 0.042 0 0
Disease R-HSA-1643685 9.109329e-01 0.041 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.122501e-01 0.040 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.122501e-01 0.040 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.122501e-01 0.040 0 0
Serine metabolism R-HSA-977347 9.122501e-01 0.040 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.122501e-01 0.040 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.122501e-01 0.040 0 0
Attachment and Entry R-HSA-9694614 9.122501e-01 0.040 0 0
Elastic fibre formation R-HSA-1566948 9.124614e-01 0.040 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.124614e-01 0.040 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.151363e-01 0.039 0 0
Pentose phosphate pathway R-HSA-71336 9.185893e-01 0.037 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.185893e-01 0.037 0 0
Signaling by ALK R-HSA-201556 9.185893e-01 0.037 0 0
Signaling by KIT in disease R-HSA-9669938 9.198186e-01 0.036 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.198186e-01 0.036 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.198186e-01 0.036 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.198186e-01 0.036 0 0
Notch-HLH transcription pathway R-HSA-350054 9.198186e-01 0.036 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.198186e-01 0.036 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.198186e-01 0.036 0 0
Cellular hexose transport R-HSA-189200 9.198186e-01 0.036 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.198186e-01 0.036 0 0
Diseases of Immune System R-HSA-5260271 9.243120e-01 0.034 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.243120e-01 0.034 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.246273e-01 0.034 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.250482e-01 0.034 0 0
Regulation of insulin secretion R-HSA-422356 9.262569e-01 0.033 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.267347e-01 0.033 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.267347e-01 0.033 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.267347e-01 0.033 0 0
Formation of the ureteric bud R-HSA-9830674 9.267347e-01 0.033 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.267347e-01 0.033 0 0
Carnitine shuttle R-HSA-200425 9.267347e-01 0.033 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.269671e-01 0.033 0 0
Maturation of spike protein R-HSA-9694548 9.296536e-01 0.032 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.296536e-01 0.032 0 0
Integration of energy metabolism R-HSA-163685 9.317420e-01 0.031 0 0
Gastrulation R-HSA-9758941 9.323552e-01 0.030 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.327911e-01 0.030 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.330547e-01 0.030 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.330547e-01 0.030 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.330547e-01 0.030 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.330547e-01 0.030 0 0
Complex III assembly R-HSA-9865881 9.330547e-01 0.030 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.330547e-01 0.030 0 0
Interleukin-6 family signaling R-HSA-6783589 9.330547e-01 0.030 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.346373e-01 0.029 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.346373e-01 0.029 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.388298e-01 0.027 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.388298e-01 0.027 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.388298e-01 0.027 0 0
G protein gated Potassium channels R-HSA-1296059 9.388298e-01 0.027 0 0
Hyaluronan degradation R-HSA-2160916 9.388298e-01 0.027 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.388298e-01 0.027 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.388298e-01 0.027 0 0
Laminin interactions R-HSA-3000157 9.388298e-01 0.027 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.392851e-01 0.027 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.392851e-01 0.027 0 0
PI Metabolism R-HSA-1483255 9.398852e-01 0.027 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.402816e-01 0.027 0 0
Iron uptake and transport R-HSA-917937 9.402816e-01 0.027 0 0
Metabolism of polyamines R-HSA-351202 9.436605e-01 0.025 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.441071e-01 0.025 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.441071e-01 0.025 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.441071e-01 0.025 0 0
TRP channels R-HSA-3295583 9.441071e-01 0.025 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.441071e-01 0.025 0 0
Sphingolipid catabolism R-HSA-9845614 9.441071e-01 0.025 0 0
Aquaporin-mediated transport R-HSA-445717 9.472412e-01 0.024 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.489293e-01 0.023 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.489293e-01 0.023 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.489293e-01 0.023 0 0
Insulin processing R-HSA-264876 9.489293e-01 0.023 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.489293e-01 0.023 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.500985e-01 0.022 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 9.514159e-01 0.022 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.514159e-01 0.022 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.533358e-01 0.021 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.566385e-01 0.019 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.573623e-01 0.019 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.573623e-01 0.019 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.573623e-01 0.019 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.573623e-01 0.019 0 0
Glucagon-type ligand receptors R-HSA-420092 9.573623e-01 0.019 0 0
Platelet calcium homeostasis R-HSA-418360 9.573623e-01 0.019 0 0
Synthesis of PC R-HSA-1483191 9.581772e-01 0.019 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.586113e-01 0.018 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.601834e-01 0.018 0 0
DAP12 signaling R-HSA-2424491 9.610416e-01 0.017 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.610416e-01 0.017 0 0
Neurotransmitter clearance R-HSA-112311 9.610416e-01 0.017 0 0
GPER1 signaling R-HSA-9634597 9.612101e-01 0.017 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.640312e-01 0.016 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.640312e-01 0.016 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.644036e-01 0.016 0 0
Cargo concentration in the ER R-HSA-5694530 9.644036e-01 0.016 0 0
Formation of the cornified envelope R-HSA-6809371 9.645125e-01 0.016 0 0
Kidney development R-HSA-9830369 9.646365e-01 0.016 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.657178e-01 0.015 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.674610e-01 0.014 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.674757e-01 0.014 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.687714e-01 0.014 0 0
Cardiogenesis R-HSA-9733709 9.702827e-01 0.013 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.713312e-01 0.013 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.713596e-01 0.013 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.726959e-01 0.012 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.728477e-01 0.012 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.728477e-01 0.012 0 0
Nucleotide biosynthesis R-HSA-8956320 9.734651e-01 0.012 0 0
Interferon alpha/beta signaling R-HSA-909733 9.745984e-01 0.011 0 0
Metabolism of proteins R-HSA-392499 9.747136e-01 0.011 0 0
Hyaluronan metabolism R-HSA-2142845 9.751914e-01 0.011 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.751914e-01 0.011 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.751914e-01 0.011 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.751914e-01 0.011 0 0
Paracetamol ADME R-HSA-9753281 9.772366e-01 0.010 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.773330e-01 0.010 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.773330e-01 0.010 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.773330e-01 0.010 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.773330e-01 0.010 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.792898e-01 0.009 0 0
GPVI-mediated activation cascade R-HSA-114604 9.792898e-01 0.009 0 0
Synthesis of PA R-HSA-1483166 9.804867e-01 0.009 0 0
Platelet homeostasis R-HSA-418346 9.809007e-01 0.008 0 0
Lysine catabolism R-HSA-71064 9.810778e-01 0.008 0 0
Signaling by Insulin receptor R-HSA-74752 9.816366e-01 0.008 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.819382e-01 0.008 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.827115e-01 0.008 0 0
Triglyceride metabolism R-HSA-8979227 9.832846e-01 0.007 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.832846e-01 0.007 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.832846e-01 0.007 0 0
Cholesterol biosynthesis R-HSA-191273 9.834151e-01 0.007 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.842042e-01 0.007 0 0
tRNA Aminoacylation R-HSA-379724 9.845333e-01 0.007 0 0
Tryptophan catabolism R-HSA-71240 9.855682e-01 0.006 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.865720e-01 0.006 0 0
Intra-Golgi traffic R-HSA-6811438 9.879531e-01 0.005 0 0
Activation of GABAB receptors R-HSA-991365 9.889935e-01 0.005 0 0
GABA B receptor activation R-HSA-977444 9.889935e-01 0.005 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.889939e-01 0.005 0 0
DAP12 interactions R-HSA-2172127 9.908127e-01 0.004 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.910578e-01 0.004 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.916063e-01 0.004 0 0
Parasitic Infection Pathways R-HSA-9824443 9.920395e-01 0.003 0 0
Leishmania infection R-HSA-9658195 9.920395e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.934390e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.934823e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.934823e-01 0.003 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.939798e-01 0.003 0 0
Extracellular matrix organization R-HSA-1474244 9.941532e-01 0.003 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.946575e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.948656e-01 0.002 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.950969e-01 0.002 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.951191e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.957648e-01 0.002 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.959263e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.962708e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.965583e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.970722e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.971624e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.973913e-01 0.001 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.975057e-01 0.001 0 0
GABA receptor activation R-HSA-977443 9.978365e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.979156e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.980069e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.980236e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.983506e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.984933e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.986148e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.986919e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.986962e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.988089e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.988514e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.988853e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.989507e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.991244e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.991333e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.991333e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.992002e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.992015e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.992694e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.993223e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.993326e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.997467e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.997534e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.998121e-01 0.000 0 0
Keratinization R-HSA-6805567 9.998158e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998393e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.998906e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998906e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999231e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999312e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999367e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999367e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999472e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999547e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999580e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999654e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999664e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999669e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999703e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999822e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999852e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999952e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999952e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999953e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999958e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999966e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999967e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999968e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999970e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999971e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999978e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999981e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999983e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999988e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999989e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999991e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999992e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways