WNK3

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
A6NKT7 S980 Sugiyama RGPD3 RGP3 GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O14715 S979 Sugiyama RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3 GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O15212 T107 Sugiyama PFDN6 HKE2 PFD6 IKRYESQLRDLERQsEQQREtLAQLQQEFQRAQAAKAGAPG
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43707 S763 Sugiyama ACTN4 IARTINEVENQILtRDAKGIsQEQMQEFRASFNHFDKDHGG
O60739 T46 Sugiyama EIF1B GTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKKK
O60841 T78 Sugiyama EIF5B IF2 KIAA0741 ILKELEELsLEAQGIKADREtVAVKPTENNEEEFtsKDKKK
O75643 S17 Sugiyama SNRNP200 ASCC3L1 BRR2 HELIC2 KIAA0788 ____MADVTARsLQYEYKANsNLVLQADRsLIDRTRRDEPT
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 S319 Sugiyama LDHA PIG19 GISDLVKVTLtsEEEARLKKsADtLWGIQKELQF_______
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00491 S163 Sugiyama PNP NP GQNPLRGPNDERFGDRFPAMsDAyDRtMRQRALstWKQMGE
P00558 S174 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558 S175 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P04040 S515 Sugiyama CAT ALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL________
P04040 T511 Sugiyama CAT SHIQALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL____
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04406 S210 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05783 S305 Sugiyama KRT18 CYK18 PIG46 QSAEVGAAETTLTELRRtVQsLEIDLDsMRNLKAsLENsLR
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733 T19 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 __MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGA
P06733 T26 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S391 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08238 S383 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 T83 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB sKLDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLG
P08238 T85 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238 T94 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSGtKAFM
P08670 S325 Sugiyama VIM NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P08758 S116 Sugiyama ANXA5 ANX5 ENX2 PP4 LKHALKGAGTNEKVLtEIIAsRtPEELRAIKQVyEEEyGss
P08758 T111 Sugiyama ANXA5 ANX5 ENX2 PP4 yDAyELKHALKGAGTNEKVLtEIIAsRtPEELRAIKQVyEE
P0DJD0 S964 Sugiyama RGPD1 RANBP2L6 RGP1 GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412 S58 Sugiyama H1-4 H1F4 HIST1H1E PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 S85 Sugiyama HSPA8 HSC70 HSP73 HSPA10 NtVFDAKRLIGRRFDDAVVQsDMKHWPFMVVNDAGRPKVQV
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11279 S141 Sugiyama LAMP1 NLSDTHLFPNASSKEIKtVEsITDIRADIDKKYRCVSGTQV
P13639 S584 Sugiyama EEF2 EF2 DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13861 S58 Sugiyama PRKAR2A PKR2 PRKAR2 TRLREARAPAsVLPAAtPRQsLGHPPPEPGPDRVADAKGDs
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618 S205 Sugiyama PKM OIP3 PK2 PK3 PKM2 VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14618 S55 Sugiyama PKM OIP3 PK2 PK3 PKM2 IDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMNVARLN
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S172 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14625 S551 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKEKQDKIyFMAGsSRKEAEssPFVERLLKKGyEVIyLTEP
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402 S59 Sugiyama H1-3 H1F3 HIST1H1D PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S58 Sugiyama H1-2 H1F2 HIST1H1C PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S328 Sugiyama NCL NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S225 Sugiyama HNRNPA2B1 HNRPA2B1 GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P25398 S107 Sugiyama RPS12 EWVGLCKIDREGKPRKVVGCsCVVVKDYGKESQAKDVIEEy
P25705 S76 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM EERILGADtsVDLEETGRVLsIGDGIARVHGLRNVQAEEMV
P26232 S667 Sugiyama CTNNA2 CAPR YDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEEKAKIAEQV
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 S97 Sugiyama RPL13 BBC1 OK/SW-cl.46 sLEELRVAGIHKKVARTIGIsVDPRRRNKstEsLQANVQRL
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27695 S135 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 SHQYWSAPsDKEGysGVGLLsRQCPLKVsyGIGDEEHDQEG
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29144 S93 Sugiyama TPP2 SGDVNTATEVEPKDGEIVGLsGRVLKIPASWTNPSGKYHIG
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692 S60 Sugiyama EEF1D EF1D ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P29692 S65 Sugiyama EEF1D EF1D VILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRIA
P29692 S70 Sugiyama EEF1D EF1D IARARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVE
P29692 S74 Sugiyama EEF1D EF1D RENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVENQsL
P29692 T73 Sugiyama EEF1D EF1D ARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVENQs
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30101 S98 Sugiyama PDIA3 ERP57 ERP60 GRP58 VPLAKVDCTANTNTCNKyGVsGyPtLKIFRDGEEAGAyDGP
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30622 S383 Sugiyama CLIP1 CYLN1 RSN HIEQLLAERDLERAEVAKAtsHVGEIEQELALARDGHDQHV
P30622 T382 Sugiyama CLIP1 CYLN1 RSN QHIEQLLAERDLERAEVAKAtsHVGEIEQELALARDGHDQH
P31327 T45 Sugiyama CPS1 AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P31948 Y354 Sugiyama STIP1 DVLKKCQQAEKILKEQERLAyINPDLALEEKNKGNECFQKG
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P35221 S668 Sugiyama CTNNA1 FDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEQKAKIAEQV
P35241 S532 Sugiyama RDX EERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHA
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35579 S1916 Sugiyama MYH9 LQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMAR
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37802 T190 Sugiyama TAGLN2 KIAA0120 CDABP0035 GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P37802 Y192 Sugiyama TAGLN2 KIAA0120 CDABP0035 NVIGLQMGtNRGAsQAGMtGyGMPRQIL_____________
P38646 S212 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 tVPAyFNDsQRQAtKDAGQIsGLNVLRVINEPTAAALAyGL
P38646 S549 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 IVHVSAKDKGTGREQQIVIQssGGLsKDDIENMVKNAEKYA
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P41567 T46 Sugiyama EIF1 SUI1 GTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKKK
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46776 S106 Sugiyama RPL27A tRVNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKA
P46776 Y108 Sugiyama RPL27A VNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKAKF
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P47712 S729 Sugiyama PLA2G4A CPLA2 PLA2G4 KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA
P47914 S142 Sugiyama RPL29 KAKAKAKAKDQTKAQAAAPAsVPAQAPKRtQAPtKAsE___
P47914 T151 Sugiyama RPL29 DQTKAQAAAPAsVPAQAPKRtQAPtKAsE____________
P47914 T155 Sugiyama RPL29 AQAAAPAsVPAQAPKRtQAPtKAsE________________
P48643 S270 Sugiyama CCT5 CCTE KIAA0098 ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49792 S1955 Sugiyama RANBP2 NUP358 GVIFGQTSSTFTFADLAKstsGEGFQFGKKDPNFKGFSGAG
P50238 Y12 Sugiyama CRIP1 CRIP CRP1 _________MPKCPKCNKEVyFAERVTSLGKDWHRPCLKCE
P50991 S51 Sugiyama CCT4 CCTD SRB AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt
P50991 T50 Sugiyama CCT4 CCTD SRB PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P51116 T610 Sugiyama FXR2 FMR1L2 RRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLER
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P60174 S106 Sugiyama TPI1 TPI DCGAtWVVLGHsERRHVFGEsDELIGQKVAHALAEGLGVIA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709 T304 Sugiyama ACTB KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P60900 S175 Sugiyama PSMA6 PROS27 DPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTV
P60900 T173 Sugiyama PSMA6 PROS27 KCDPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQ
P61221 Y594 Sugiyama ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T22 Sugiyama RPL31 APAKKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRA
P62899 Y25 Sugiyama RPL31 KKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRA
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63220 S65 Sugiyama RPS21 RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261 T304 Sugiyama ACTG1 ACTG KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 Y72 Sugiyama YBX1 NSEP1 YB1 KKVIATKVLGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIK
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q06830 S152 Sugiyama PRDX1 PAGA PAGB TDPX2 IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q13263 S784 Sugiyama TRIM28 KAP1 RNF96 TIF1B DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13283 S67 Sugiyama G3BP1 G3BP sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13428 S1410 Sugiyama TCOF1 AKRDKASGDVKEKKGKGsLGsQGAKDEPEEELQKGMGTVEG
Q14204 S3257 Sugiyama DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 NDKLKKMVKDQQEAEKKKVMsQEIQEQLHKQQEVIADKQMS
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14847 S99 Sugiyama LASP1 MLN50 ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q15185 S82 Sugiyama PTGES3 P23 TEBP NDsKHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVD
Q15417 S259 Sugiyama CNN3 DNSTISLQMGTNKVAsQKGMsVyGLGRQVYDPKYCAAPTEP
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q562R1 T107 Sugiyama ACTBL2 WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q6DD87 S104 Sugiyama ZNF787 HQRTHtGERPNACADCGKTFsQSSHLVQHRRIHtGEKPYAC
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7Z3J3 S980 Sugiyama RGPD4 RGP4 GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
Q7Z4V5 S396 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 EDDEPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKKP
Q86V81 S145 Sugiyama ALYREF ALY BEF THOC4 LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBS9 S426 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 KKVSEHSGGRDLDSLHRFVLsQAKDEL______________
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q96C19 S74 Sugiyama EFHD2 SWS1 ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96C19 S76 Sugiyama EFHD2 SWS1 SAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQIKD
Q96CT7 S122 Sugiyama CCDC124 DtLRRDHQLREAPDTAEKAKsHLEVPLEENVNRRVLEEGsV
Q99666 S979 Sugiyama RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6 GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BYP7 S422 Sugiyama WNK3 KIAA1566 PRKWNK3 HAFFAEDTGLRVELAEEDDCsNssLALRLWVEDPKKLKGKH
Q9BYP7 S424 Sugiyama WNK3 KIAA1566 PRKWNK3 FFAEDTGLRVELAEEDDCsNssLALRLWVEDPKKLKGKHKD
Q9BYP7 S425 Sugiyama WNK3 KIAA1566 PRKWNK3 FAEDTGLRVELAEEDDCsNssLALRLWVEDPKKLKGKHKDN
Q9BYP7 S44 Sugiyama WNK3 KIAA1566 PRKWNK3 NRVPQVAATLTVEARLKEKNstFsAsGEtVERKRFFRKsVE
Q9BYP7 S47 Sugiyama WNK3 KIAA1566 PRKWNK3 PQVAATLTVEARLKEKNstFsAsGEtVERKRFFRKsVEMTE
Q9BYP7 S49 Sugiyama WNK3 KIAA1566 PRKWNK3 VAATLTVEARLKEKNstFsAsGEtVERKRFFRKsVEMTEDD
Q9BYP7 T45 Sugiyama WNK3 KIAA1566 PRKWNK3 RVPQVAATLTVEARLKEKNstFsAsGEtVERKRFFRKsVEM
Q9BYP7 T52 Sugiyama WNK3 KIAA1566 PRKWNK3 TLTVEARLKEKNstFsAsGEtVERKRFFRKsVEMTEDDKVA
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9H4A3 S382 SIGNOR|EPSD|PSP WNK1 HSN2 KDP KIAA0344 PRKWNK1 GsVKIGDLGLATLKRAsFAKsVIGtPEFMAPEMYEEKYDES
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NQZ2 S462 Sugiyama UTP3 CRLZ1 SAS10 RAKIRRRGQVREVRKEEQRYsGELsGIRAGVKKSIKLK___
Q9NYF8 S320 Sugiyama BCLAF1 BTF KIAA0164 sPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRF
Q9UHV9 S22 Sugiyama PFDN2 PFD2 HSPC231 AENSGRAGKssGSGAGKGAVsAEQVIAGFNRLRQEQRGLAS
Q9UHW9 S96 SIGNOR|EPSD|PSP SLC12A6 KCC3 DPPSDRTSHPQDVIEDLsQNsItGEHSQLLDDGHKKARNAY
Q9UHW9 T1048 SIGNOR|EPSD|PSP SLC12A6 KCC3 tsIGsDEDEEtETYQEKVHMtWTKDKYMASRGQKAKsMEGF
Q9UHW9 T991 SIGNOR|EPSD|PSP SLC12A6 KCC3 AEVEVVEMHDSDISAYTYERtLMMEQRSQMLRHMRLSKTER
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UI15 T190 Sugiyama TAGLN3 NP25 GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9UI15 Y192 Sugiyama TAGLN3 NP25 NVIGLQMGSNKGAsQAGMtGyGMPRQIM_____________
Q9UII2 S39 Sugiyama ATP5IF1 ATPI ATPIF1 TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF
Q9UII2 S63 Sugiyama ATP5IF1 ATPI ATPIF1 AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UNZ2 S192 Sugiyama NSFL1C UBXN2C KRQHssQDVHVVLKLWKsGFsLDNGELRSyQDPsNAQFLEs
Q9UNZ2 S74 Sugiyama NSFL1C UBXN2C SQATPssVsRGTAPSDNRVtsFRDLIHDQDEDEEEEEGQRF
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2L5 S377 Sugiyama TRAPPC8 KIAA1012 FRGLLPHIEKTIRQLNDQLIsRKGLSRSLFSATKKWFSGSK
Q9Y2T7 Y107 Sugiyama YBX2 CSDA3 MSY2 KPVLAIQVLGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIK
Q9Y5L4 S57 Sugiyama TIMM13 TIM13B TIMM13A TIMM13B ELLQRMTDKCFRKCIGKPGGsLDNSEQKCIAMCMDRyMDAW
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.316480e-12 11.635 0 0
Signal Transduction R-HSA-162582 2.666082e-09 8.574 0 0
Cell Cycle Checkpoints R-HSA-69620 3.953786e-08 7.403 0 0
Axon guidance R-HSA-422475 4.284159e-08 7.368 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.518685e-08 7.258 0 0
Cell Cycle, Mitotic R-HSA-69278 1.805048e-07 6.744 0 0
Nervous system development R-HSA-9675108 4.477144e-07 6.349 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 8.071365e-07 6.093 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.392965e-06 5.856 0 0
HSF1-dependent transactivation R-HSA-3371571 2.049701e-06 5.688 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.424506e-06 5.465 0 0
Mitotic Prometaphase R-HSA-68877 5.144700e-06 5.289 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.652680e-06 5.015 0 0
Regulation of TP53 Activity R-HSA-5633007 1.263746e-05 4.898 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.572317e-05 4.803 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.562789e-05 4.806 0 0
EPH-Ephrin signaling R-HSA-2682334 1.567455e-05 4.805 0 0
Apoptotic execution phase R-HSA-75153 1.471932e-05 4.832 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.659695e-05 4.780 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.748874e-05 4.757 0 0
Muscle contraction R-HSA-397014 1.755205e-05 4.756 0 0
Attenuation phase R-HSA-3371568 1.934402e-05 4.713 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.577038e-05 4.589 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.306936e-05 4.366 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.497255e-05 4.347 0 0
HSF1 activation R-HSA-3371511 6.033647e-05 4.219 0 0
FOXO-mediated transcription R-HSA-9614085 6.557114e-05 4.183 0 0
Post NMDA receptor activation events R-HSA-438064 6.820110e-05 4.166 0 0
PKMTs methylate histone lysines R-HSA-3214841 7.884001e-05 4.103 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 9.068535e-05 4.042 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.065682e-04 3.972 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.055479e-04 3.977 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.065682e-04 3.972 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.105243e-04 3.957 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.105243e-04 3.957 0 0
Kinesins R-HSA-983189 1.516387e-04 3.819 0 0
Ion homeostasis R-HSA-5578775 1.672187e-04 3.777 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.689379e-04 3.772 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.786944e-04 3.748 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.944602e-04 3.711 0 0
Semaphorin interactions R-HSA-373755 2.766023e-04 3.558 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.945144e-04 3.531 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.136560e-04 3.504 0 0
G alpha (12/13) signalling events R-HSA-416482 3.276385e-04 3.485 0 0
NRAGE signals death through JNK R-HSA-193648 4.223676e-04 3.374 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.279941e-04 3.369 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.784115e-04 3.320 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.328652e-04 3.273 0 0
Ephrin signaling R-HSA-3928664 5.328652e-04 3.273 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.232701e-04 3.281 0 0
Separation of Sister Chromatids R-HSA-2467813 5.378217e-04 3.269 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.791350e-04 3.237 0 0
Cellular response to heat stress R-HSA-3371556 5.864256e-04 3.232 0 0
L1CAM interactions R-HSA-373760 6.005958e-04 3.221 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.074927e-04 3.216 0 0
G2/M Checkpoints R-HSA-69481 7.305743e-04 3.136 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.125822e-04 3.147 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.876370e-04 3.104 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.751614e-04 3.111 0 0
M Phase R-HSA-68886 7.804260e-04 3.108 0 0
TRP channels R-HSA-3295583 7.886207e-04 3.103 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 9.368388e-04 3.028 0 0
ChREBP activates metabolic gene expression R-HSA-163765 9.824233e-04 3.008 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 9.673305e-04 3.014 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.002537e-03 2.999 0 0
G2/M Transition R-HSA-69275 1.053187e-03 2.977 0 0
Death Receptor Signaling R-HSA-73887 1.053041e-03 2.978 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.136861e-03 2.944 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.161650e-03 2.935 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.308423e-03 2.883 0 0
Cardiac conduction R-HSA-5576891 1.311966e-03 2.882 0 0
Generic Transcription Pathway R-HSA-212436 1.340541e-03 2.873 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.350515e-03 2.870 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.472302e-03 2.832 0 0
RNA Polymerase II Transcription R-HSA-73857 1.518546e-03 2.819 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.564248e-03 2.806 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.568561e-03 2.804 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.608222e-03 2.794 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.766868e-03 2.753 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.783674e-03 2.749 0 0
Diseases of DNA repair R-HSA-9675135 2.165155e-03 2.665 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.260693e-03 2.646 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.537811e-03 2.596 0 0
Rap1 signalling R-HSA-392517 2.537811e-03 2.596 0 0
Gene expression (Transcription) R-HSA-74160 2.474123e-03 2.607 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.507235e-03 2.601 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.717219e-03 2.566 0 0
Homology Directed Repair R-HSA-5693538 2.721021e-03 2.565 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.406922e-03 2.468 0 0
Meiosis R-HSA-1500620 4.122829e-03 2.385 0 0
Apoptosis R-HSA-109581 3.967192e-03 2.402 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.135190e-03 2.384 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.276337e-03 2.369 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.617749e-03 2.336 0 0
Platelet calcium homeostasis R-HSA-418360 4.765344e-03 2.322 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.698271e-03 2.244 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.928471e-03 2.227 0 0
Activation of RAC1 R-HSA-428540 5.952752e-03 2.225 0 0
Recycling pathway of L1 R-HSA-437239 5.974061e-03 2.224 0 0
Polo-like kinase mediated events R-HSA-156711 6.041776e-03 2.219 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.323799e-03 2.199 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.708729e-03 2.173 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.749498e-03 2.171 0 0
Cellular Senescence R-HSA-2559583 7.509975e-03 2.124 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.081412e-03 2.093 0 0
Aggrephagy R-HSA-9646399 7.996092e-03 2.097 0 0
Netrin-1 signaling R-HSA-373752 8.158459e-03 2.088 0 0
The NLRP3 inflammasome R-HSA-844456 7.848790e-03 2.105 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.160621e-03 2.088 0 0
Mitotic Anaphase R-HSA-68882 8.604504e-03 2.065 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 9.126326e-03 2.040 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 9.126326e-03 2.040 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 9.126326e-03 2.040 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.978581e-03 2.047 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.227979e-03 2.035 0 0
RET signaling R-HSA-8853659 9.227979e-03 2.035 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 9.235374e-03 2.035 0 0
RAB geranylgeranylation R-HSA-8873719 9.290038e-03 2.032 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 9.539538e-03 2.020 0 0
Nef and signal transduction R-HSA-164944 9.539538e-03 2.020 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.081869e-02 1.966 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.128764e-02 1.947 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.106087e-02 1.956 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.132187e-02 1.946 0 0
Neurodegenerative Diseases R-HSA-8863678 1.132187e-02 1.946 0 0
Reproduction R-HSA-1474165 1.096961e-02 1.960 0 0
DNA Double Strand Break Response R-HSA-5693606 1.174609e-02 1.930 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.228984e-02 1.910 0 0
Signaling by ALK in cancer R-HSA-9700206 1.228984e-02 1.910 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.244696e-02 1.905 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.271891e-02 1.896 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.317481e-02 1.880 0 0
Rab regulation of trafficking R-HSA-9007101 1.318129e-02 1.880 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.330088e-02 1.876 0 0
Signaling by Hippo R-HSA-2028269 1.394505e-02 1.856 0 0
Specification of primordial germ cells R-HSA-9827857 1.394505e-02 1.856 0 0
Interleukin-37 signaling R-HSA-9008059 1.469442e-02 1.833 0 0
Co-stimulation by CD28 R-HSA-389356 1.499643e-02 1.824 0 0
MAPK family signaling cascades R-HSA-5683057 1.522337e-02 1.817 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.526566e-02 1.816 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.576500e-02 1.802 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.576500e-02 1.802 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.624891e-02 1.789 0 0
Signaling by ROBO receptors R-HSA-376176 1.695322e-02 1.771 0 0
Neuronal System R-HSA-112316 1.725076e-02 1.763 0 0
Signaling by VEGF R-HSA-194138 1.759909e-02 1.755 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.798076e-02 1.745 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.798076e-02 1.745 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.944021e-02 1.711 0 0
mRNA Splicing R-HSA-72172 1.933946e-02 1.714 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.944021e-02 1.711 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.952361e-02 1.709 0 0
Diseases of cellular response to stress R-HSA-9675132 1.952361e-02 1.709 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.987979e-02 1.702 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.077518e-02 1.682 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.077518e-02 1.682 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.072726e-02 1.683 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.072726e-02 1.683 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.038627e-02 1.691 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.084827e-02 1.681 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.026021e-02 1.693 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.188531e-02 1.660 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.038627e-02 1.691 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.188531e-02 1.660 0 0
Developmental Biology R-HSA-1266738 2.143680e-02 1.669 0 0
Programmed Cell Death R-HSA-5357801 2.062990e-02 1.686 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.071473e-02 1.684 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.077518e-02 1.682 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.169040e-02 1.664 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.190212e-02 1.660 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.204977e-02 1.657 0 0
Selective autophagy R-HSA-9663891 2.209698e-02 1.656 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.329550e-02 1.633 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.329550e-02 1.633 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.329550e-02 1.633 0 0
Signaling by RAS mutants R-HSA-6802949 2.329550e-02 1.633 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.365158e-02 1.626 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.434216e-02 1.614 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.437774e-02 1.613 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.715010e-02 1.566 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.715010e-02 1.566 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.715010e-02 1.566 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.715010e-02 1.566 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.455363e-02 1.610 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.495252e-02 1.603 0 0
Sensory processing of sound R-HSA-9659379 2.484439e-02 1.605 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.452001e-02 1.610 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.722160e-02 1.565 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.722160e-02 1.565 0 0
Chromatin modifying enzymes R-HSA-3247509 2.729133e-02 1.564 0 0
PKR-mediated signaling R-HSA-9833482 2.750216e-02 1.561 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.753518e-02 1.560 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.753518e-02 1.560 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.753518e-02 1.560 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.838320e-02 1.547 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.838320e-02 1.547 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.870394e-02 1.542 0 0
ALK mutants bind TKIs R-HSA-9700645 2.870394e-02 1.542 0 0
Striated Muscle Contraction R-HSA-390522 2.871550e-02 1.542 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.882233e-02 1.540 0 0
DNA Repair R-HSA-73894 2.886728e-02 1.540 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.896415e-02 1.538 0 0
Centrosome maturation R-HSA-380287 2.918682e-02 1.535 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.281315e-02 1.484 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.281315e-02 1.484 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.281315e-02 1.484 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.301506e-02 1.481 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.030092e-02 1.519 0 0
Cellular responses to stimuli R-HSA-8953897 2.947544e-02 1.531 0 0
Potassium Channels R-HSA-1296071 3.302514e-02 1.481 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.365983e-02 1.473 0 0
HDMs demethylate histones R-HSA-3214842 3.383104e-02 1.471 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.383104e-02 1.471 0 0
Long-term potentiation R-HSA-9620244 3.383104e-02 1.471 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.385803e-02 1.470 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 3.493574e-02 1.457 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.493574e-02 1.457 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.493574e-02 1.457 0 0
Cellular responses to stress R-HSA-2262752 3.507105e-02 1.455 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.564035e-02 1.448 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.644174e-02 1.438 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.708083e-02 1.431 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.708083e-02 1.431 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.961704e-02 1.402 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.968706e-02 1.401 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.243274e-02 1.372 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.851235e-02 1.414 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.961704e-02 1.402 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.961704e-02 1.402 0 0
Meiotic recombination R-HSA-912446 4.331607e-02 1.363 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.031589e-02 1.395 0 0
Deubiquitination R-HSA-5688426 4.332996e-02 1.363 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.832007e-02 1.417 0 0
DAG and IP3 signaling R-HSA-1489509 4.053631e-02 1.392 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.095430e-02 1.388 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.823681e-02 1.418 0 0
Membrane Trafficking R-HSA-199991 4.392784e-02 1.357 0 0
Chromatin organization R-HSA-4839726 4.392997e-02 1.357 0 0
Signaling by TGFBR3 R-HSA-9839373 4.571454e-02 1.340 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.648395e-02 1.333 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.648395e-02 1.333 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.679939e-02 1.330 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.679939e-02 1.330 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.679939e-02 1.330 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.705026e-02 1.327 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.720183e-02 1.326 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.759448e-02 1.322 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.759448e-02 1.322 0 0
Signaling by PTK6 R-HSA-8848021 4.759448e-02 1.322 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.759448e-02 1.322 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.380017e-02 1.269 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.380017e-02 1.269 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.380017e-02 1.269 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.425361e-02 1.266 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.558782e-02 1.255 0 0
Integrin signaling R-HSA-354192 5.256820e-02 1.279 0 0
Voltage gated Potassium channels R-HSA-1296072 5.042533e-02 1.297 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.070980e-02 1.295 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.311825e-02 1.275 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.528032e-02 1.257 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.810650e-02 1.318 0 0
Neurexins and neuroligins R-HSA-6794361 4.844722e-02 1.315 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.810650e-02 1.318 0 0
MTOR signalling R-HSA-165159 5.427904e-02 1.265 0 0
Autophagy R-HSA-9612973 5.597832e-02 1.252 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.380017e-02 1.269 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.380017e-02 1.269 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.425361e-02 1.266 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.558782e-02 1.255 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.427178e-02 1.265 0 0
Formation of the anterior neural plate R-HSA-9823739 5.425361e-02 1.266 0 0
Inflammasomes R-HSA-622312 5.437441e-02 1.265 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.256820e-02 1.279 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.708386e-02 1.243 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.757871e-02 1.240 0 0
Translation initiation complex formation R-HSA-72649 5.994397e-02 1.222 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.007907e-02 1.221 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.184770e-02 1.209 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.270344e-02 1.203 0 0
DARPP-32 events R-HSA-180024 6.270438e-02 1.203 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.270438e-02 1.203 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.283394e-02 1.202 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.283394e-02 1.202 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.283394e-02 1.202 0 0
Signaling by ALK R-HSA-201556 6.460154e-02 1.190 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.742021e-02 1.171 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 6.742021e-02 1.171 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 6.742021e-02 1.171 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 6.742021e-02 1.171 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 6.742021e-02 1.171 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 6.742021e-02 1.171 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 6.742021e-02 1.171 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 6.742021e-02 1.171 0 0
IRS activation R-HSA-74713 7.729315e-02 1.112 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 7.729315e-02 1.112 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 7.729315e-02 1.112 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.146459e-02 1.146 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.775031e-02 1.109 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.775031e-02 1.109 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.775031e-02 1.109 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.775031e-02 1.109 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.775031e-02 1.109 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.592394e-02 1.181 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.616962e-02 1.179 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.180311e-02 1.144 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 7.315336e-02 1.136 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.716734e-02 1.113 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.716734e-02 1.113 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.641078e-02 1.178 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.641078e-02 1.178 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.641078e-02 1.178 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.315336e-02 1.136 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.667481e-02 1.115 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 6.582240e-02 1.182 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.667481e-02 1.115 0 0
Chromosome Maintenance R-HSA-73886 7.134168e-02 1.147 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 7.729315e-02 1.112 0 0
Macroautophagy R-HSA-1632852 6.492584e-02 1.188 0 0
Adrenoceptors R-HSA-390696 7.146459e-02 1.146 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.775031e-02 1.109 0 0
Signaling by LTK R-HSA-9842663 7.775031e-02 1.109 0 0
Oncogene Induced Senescence R-HSA-2559585 7.710302e-02 1.113 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.500586e-02 1.187 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.146459e-02 1.146 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.592394e-02 1.181 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.756969e-02 1.110 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.108249e-02 1.091 0 0
FLT3 Signaling R-HSA-9607240 8.114086e-02 1.091 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.167860e-02 1.088 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.382810e-02 1.077 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.419490e-02 1.075 0 0
mRNA 3'-end processing R-HSA-72187 8.647307e-02 1.063 0 0
Calmodulin induced events R-HSA-111933 8.663165e-02 1.062 0 0
CaM pathway R-HSA-111997 8.663165e-02 1.062 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.709099e-02 1.060 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.095787e-01 0.960 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.095787e-01 0.960 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.095787e-01 0.960 0 0
DSCAM interactions R-HSA-376172 1.095787e-01 0.960 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.095787e-01 0.960 0 0
C6 deamination of adenosine R-HSA-75102 1.095787e-01 0.960 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 1.095787e-01 0.960 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.095787e-01 0.960 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.095787e-01 0.960 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.095787e-01 0.960 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.095787e-01 0.960 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.095787e-01 0.960 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.095787e-01 0.960 0 0
Potassium transport channels R-HSA-1296067 1.095787e-01 0.960 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.095787e-01 0.960 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.095787e-01 0.960 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 1.095787e-01 0.960 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.095787e-01 0.960 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.044732e-01 0.981 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 1.044732e-01 0.981 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.044732e-01 0.981 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 9.109225e-02 1.041 0 0
ARMS-mediated activation R-HSA-170984 9.109225e-02 1.041 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 9.439544e-02 1.025 0 0
CD28 dependent Vav1 pathway R-HSA-389359 9.439544e-02 1.025 0 0
Formation of axial mesoderm R-HSA-9796292 9.439544e-02 1.025 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.089711e-01 0.963 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.038226e-01 0.984 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.684104e-02 1.014 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.000907e-01 1.000 0 0
Meiotic synapsis R-HSA-1221632 9.495837e-02 1.022 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 9.233292e-02 1.035 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 9.684104e-02 1.014 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.089711e-01 0.963 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.989607e-02 1.046 0 0
mRNA Editing R-HSA-75072 9.109225e-02 1.041 0 0
G-protein beta:gamma signalling R-HSA-397795 1.037622e-01 0.984 0 0
Apoptotic factor-mediated response R-HSA-111471 1.089711e-01 0.963 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.813266e-02 1.055 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 9.109225e-02 1.041 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.330689e-02 1.030 0 0
Peptide chain elongation R-HSA-156902 9.735989e-02 1.012 0 0
Signaling by NOTCH1 R-HSA-1980143 9.047857e-02 1.043 0 0
Ub-specific processing proteases R-HSA-5689880 1.061990e-01 0.974 0 0
G0 and Early G1 R-HSA-1538133 9.233292e-02 1.035 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.018888e-01 0.992 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.037622e-01 0.984 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.549545e-02 1.020 0 0
Diseases of programmed cell death R-HSA-9645723 9.735989e-02 1.012 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.044732e-01 0.981 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.044732e-01 0.981 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.929429e-02 1.049 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 1.095787e-01 0.960 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.439544e-02 1.025 0 0
Smooth Muscle Contraction R-HSA-445355 9.495837e-02 1.022 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.037360e-01 0.984 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 9.109225e-02 1.041 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.089711e-01 0.963 0 0
Glycolysis R-HSA-70171 1.097817e-01 0.959 0 0
ESR-mediated signaling R-HSA-8939211 1.100277e-01 0.958 0 0
HDL assembly R-HSA-8963896 1.126985e-01 0.948 0 0
Formation of apoptosome R-HSA-111458 1.129958e-01 0.947 0 0
Signal attenuation R-HSA-74749 1.129958e-01 0.947 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.129958e-01 0.947 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.129958e-01 0.947 0 0
PLC beta mediated events R-HSA-112043 1.139754e-01 0.943 0 0
Transmission across Chemical Synapses R-HSA-112315 1.152681e-01 0.938 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.173531e-01 0.931 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.183553e-01 0.927 0 0
Syndecan interactions R-HSA-3000170 1.184955e-01 0.926 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.193313e-01 0.923 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.232178e-01 0.909 0 0
Ion channel transport R-HSA-983712 1.233199e-01 0.909 1 0
TNF signaling R-HSA-75893 1.233629e-01 0.909 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.311086e-01 0.882 0 0
KIT mutants bind TKIs R-HSA-9669921 1.311086e-01 0.882 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.311086e-01 0.882 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.311086e-01 0.882 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.311086e-01 0.882 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.311086e-01 0.882 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.311086e-01 0.882 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.311086e-01 0.882 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.311086e-01 0.882 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.311086e-01 0.882 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.311086e-01 0.882 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.311086e-01 0.882 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.311086e-01 0.882 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.567155e-01 0.805 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.567155e-01 0.805 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.567155e-01 0.805 0 0
Axonal growth stimulation R-HSA-209563 1.567155e-01 0.805 0 0
Classical Kir channels R-HSA-1296053 1.567155e-01 0.805 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.567155e-01 0.805 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.567155e-01 0.805 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.567155e-01 0.805 0 0
CREB phosphorylation R-HSA-199920 1.348122e-01 0.870 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.348122e-01 0.870 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.369733e-01 0.863 0 0
Signaling by APC mutants R-HSA-4839744 1.369733e-01 0.863 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.369733e-01 0.863 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.369733e-01 0.863 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.369733e-01 0.863 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.627915e-01 0.788 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.627915e-01 0.788 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.325631e-01 0.878 0 0
Translesion synthesis by REV1 R-HSA-110312 1.325631e-01 0.878 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.325631e-01 0.878 0 0
Translesion synthesis by POLI R-HSA-5656121 1.538717e-01 0.813 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.538717e-01 0.813 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.439984e-01 0.842 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.393933e-01 0.856 0 0
RAF activation R-HSA-5673000 1.289011e-01 0.890 0 0
G1/S-Specific Transcription R-HSA-69205 1.569508e-01 0.804 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.330029e-01 0.876 0 0
Nucleosome assembly R-HSA-774815 1.330029e-01 0.876 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.327285e-01 0.877 0 0
Neutrophil degranulation R-HSA-6798695 1.251645e-01 0.903 0 0
G1/S Transition R-HSA-69206 1.382486e-01 0.859 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.330029e-01 0.876 0 0
Formation of definitive endoderm R-HSA-9823730 1.439984e-01 0.842 0 0
Prolonged ERK activation events R-HSA-169893 1.538717e-01 0.813 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 1.627915e-01 0.788 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.334408e-01 0.875 0 0
MHC class II antigen presentation R-HSA-2132295 1.645504e-01 0.784 0 0
MAP2K and MAPK activation R-HSA-5674135 1.578293e-01 0.802 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.261107e-01 0.899 0 0
Adipogenesis R-HSA-9843745 1.429113e-01 0.845 0 0
Signaling by TGFB family members R-HSA-9006936 1.361034e-01 0.866 0 0
Sodium/Calcium exchangers R-HSA-425561 1.627915e-01 0.788 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.538717e-01 0.813 0 0
Trafficking of AMPA receptors R-HSA-399719 1.548132e-01 0.810 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.443533e-01 0.841 0 0
Interleukin-2 signaling R-HSA-9020558 1.369733e-01 0.863 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.425744e-01 0.846 0 0
Signaling by WNT R-HSA-195721 1.518503e-01 0.819 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.281746e-01 0.892 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.538717e-01 0.813 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.325631e-01 0.878 0 0
Activation of BH3-only proteins R-HSA-114452 1.393933e-01 0.856 0 0
PECAM1 interactions R-HSA-210990 1.369733e-01 0.863 0 0
GPVI-mediated activation cascade R-HSA-114604 1.569508e-01 0.804 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.627915e-01 0.788 0 0
Signaling by AXIN mutants R-HSA-4839735 1.627915e-01 0.788 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.234870e-01 0.908 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.234870e-01 0.908 0 0
Ion transport by P-type ATPases R-HSA-936837 1.438299e-01 0.842 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.426427e-01 0.846 0 0
Stimuli-sensing channels R-HSA-2672351 1.302000e-01 0.885 1 1
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 1.538717e-01 0.813 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.659719e-01 0.780 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.677466e-01 0.775 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.677466e-01 0.775 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 1.677466e-01 0.775 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.677466e-01 0.775 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.677466e-01 0.775 0 0
PTK6 Expression R-HSA-8849473 1.677466e-01 0.775 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.677466e-01 0.775 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 1.677466e-01 0.775 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 1.677466e-01 0.775 0 0
Regulation of PTEN localization R-HSA-8948747 1.677466e-01 0.775 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.677466e-01 0.775 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.679101e-01 0.775 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.679101e-01 0.775 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.679101e-01 0.775 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.679101e-01 0.775 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.679101e-01 0.775 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.679101e-01 0.775 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.710047e-01 0.767 0 0
Ca-dependent events R-HSA-111996 1.719021e-01 0.765 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.719993e-01 0.764 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.750670e-01 0.757 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.759567e-01 0.755 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.764897e-01 0.753 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.764897e-01 0.753 0 0
Translesion synthesis by POLK R-HSA-5655862 1.764897e-01 0.753 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.764897e-01 0.753 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.764897e-01 0.753 0 0
G-protein mediated events R-HSA-112040 1.775151e-01 0.751 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.785040e-01 0.748 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.801691e-01 0.744 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.827654e-01 0.738 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.834660e-01 0.736 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.847936e-01 0.733 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.867832e-01 0.729 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.879219e-01 0.726 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.879219e-01 0.726 0 0
S Phase R-HSA-69242 1.901189e-01 0.721 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.901971e-01 0.721 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.901971e-01 0.721 0 0
Polymerase switching R-HSA-69091 1.901971e-01 0.721 0 0
Leading Strand Synthesis R-HSA-69109 1.901971e-01 0.721 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.901971e-01 0.721 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.901971e-01 0.721 0 0
Integration of energy metabolism R-HSA-163685 1.904452e-01 0.720 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.450344e-01 0.611 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.450344e-01 0.611 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.450344e-01 0.611 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.450344e-01 0.611 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.450344e-01 0.611 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.450344e-01 0.611 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.450344e-01 0.611 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.450344e-01 0.611 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.450344e-01 0.611 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.450344e-01 0.611 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.068017e-01 0.684 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.068017e-01 0.684 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.068017e-01 0.684 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.068017e-01 0.684 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.068017e-01 0.684 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.068017e-01 0.684 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.068017e-01 0.684 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.582546e-01 0.588 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.582546e-01 0.588 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.582546e-01 0.588 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.582546e-01 0.588 0 0
G2 Phase R-HSA-68911 2.582546e-01 0.588 0 0
Type I hemidesmosome assembly R-HSA-446107 2.027106e-01 0.693 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.189259e-01 0.660 0 0
PI3K/AKT activation R-HSA-198203 2.765809e-01 0.558 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 2.765809e-01 0.558 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.765809e-01 0.558 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.002699e-01 0.698 0 0
Regulation of KIT signaling R-HSA-1433559 2.487110e-01 0.604 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.250561e-01 0.648 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.250561e-01 0.648 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.046399e-01 0.689 0 0
DCC mediated attractive signaling R-HSA-418885 2.792895e-01 0.554 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.792895e-01 0.554 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.266379e-01 0.645 0 0
Deadenylation of mRNA R-HSA-429947 2.493517e-01 0.603 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.493517e-01 0.603 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.770009e-01 0.558 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.039685e-01 0.690 0 0
Activation of the pre-replicative complex R-HSA-68962 2.463646e-01 0.608 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.463646e-01 0.608 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.335639e-01 0.632 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.335639e-01 0.632 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.288544e-01 0.640 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.443887e-01 0.612 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.443887e-01 0.612 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.278080e-01 0.642 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.549536e-01 0.594 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.302076e-01 0.638 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.890971e-01 0.539 0 0
HATs acetylate histones R-HSA-3214847 2.906354e-01 0.537 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.759143e-01 0.559 0 0
Signaling by ERBB2 R-HSA-1227986 2.537053e-01 0.596 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.147064e-01 0.668 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.412305e-01 0.618 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.381565e-01 0.623 0 0
Extension of Telomeres R-HSA-180786 2.387317e-01 0.622 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.258512e-01 0.646 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.845939e-01 0.546 0 0
DNA Damage Bypass R-HSA-73893 2.844450e-01 0.546 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.726700e-01 0.564 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.412305e-01 0.618 0 0
Frs2-mediated activation R-HSA-170968 2.189259e-01 0.660 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.493517e-01 0.603 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.726700e-01 0.564 0 0
Cyclin D associated events in G1 R-HSA-69231 2.017246e-01 0.695 0 0
G1 Phase R-HSA-69236 2.017246e-01 0.695 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.149587e-01 0.668 0 0
Regulation of CDH11 function R-HSA-9762292 2.765809e-01 0.558 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.391587e-01 0.621 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.844450e-01 0.546 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.844450e-01 0.546 0 0
cGMP effects R-HSA-418457 2.487110e-01 0.604 0 0
Translesion Synthesis by POLH R-HSA-110320 2.506874e-01 0.601 0 0
Opioid Signalling R-HSA-111885 1.984596e-01 0.702 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.055140e-01 0.687 0 0
Signaling by WNT in cancer R-HSA-4791275 2.889462e-01 0.539 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.890971e-01 0.539 0 0
Sensory perception of sour taste R-HSA-9729555 2.068017e-01 0.684 0 0
TGFBR3 PTM regulation R-HSA-9839383 2.027106e-01 0.693 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.189259e-01 0.660 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.487110e-01 0.604 0 0
Signaling by NODAL R-HSA-1181150 2.770009e-01 0.558 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.237258e-01 0.650 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.420787e-01 0.616 0 0
Diseases of Immune System R-HSA-5260271 2.208076e-01 0.656 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.208076e-01 0.656 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.759725e-01 0.559 0 0
mTORC1-mediated signalling R-HSA-166208 2.046399e-01 0.689 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.671223e-01 0.573 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.381565e-01 0.623 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.765809e-01 0.558 0 0
Signaling by Activin R-HSA-1502540 2.792895e-01 0.554 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.792895e-01 0.554 0 0
Eukaryotic Translation Termination R-HSA-72764 2.418494e-01 0.616 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.250561e-01 0.648 0 0
Metabolism of RNA R-HSA-8953854 2.474255e-01 0.607 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 2.335639e-01 0.632 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 2.335639e-01 0.632 0 0
Specification of the neural plate border R-HSA-9834899 2.506874e-01 0.601 0 0
Inhibition of PKR R-HSA-169131 2.450344e-01 0.611 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.068017e-01 0.684 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.059648e-01 0.686 0 0
Gap junction trafficking and regulation R-HSA-157858 2.844450e-01 0.546 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.792895e-01 0.554 0 0
Signal transduction by L1 R-HSA-445144 2.770009e-01 0.558 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.741903e-01 0.562 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.979658e-01 0.703 0 0
Platelet homeostasis R-HSA-418346 2.299359e-01 0.638 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.391587e-01 0.621 0 0
Interleukin-1 processing R-HSA-448706 2.391587e-01 0.621 0 0
TGFBR3 expression R-HSA-9839394 2.726700e-01 0.564 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.046399e-01 0.689 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.391587e-01 0.621 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.765809e-01 0.558 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.147064e-01 0.668 0 0
NrCAM interactions R-HSA-447038 2.582546e-01 0.588 0 0
Gap junction assembly R-HSA-190861 2.237258e-01 0.650 0 0
Interleukin-7 signaling R-HSA-1266695 2.726700e-01 0.564 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.792895e-01 0.554 0 0
Signaling by Leptin R-HSA-2586552 2.765809e-01 0.558 0 0
Nephrin family interactions R-HSA-373753 2.770009e-01 0.558 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.040154e-01 0.690 0 0
Maturation of nucleoprotein R-HSA-9694631 2.506874e-01 0.601 0 0
Maturation of nucleoprotein R-HSA-9683610 2.189259e-01 0.660 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.964802e-01 0.528 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.964802e-01 0.528 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.964802e-01 0.528 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.964802e-01 0.528 0 0
Metalloprotease DUBs R-HSA-5689901 2.964802e-01 0.528 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.440284e-01 0.463 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.440284e-01 0.463 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.440284e-01 0.463 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.440284e-01 0.463 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.440284e-01 0.463 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.440284e-01 0.463 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.440284e-01 0.463 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.440284e-01 0.463 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.440284e-01 0.463 0 0
Defective CD320 causes MMATC R-HSA-3359485 3.440284e-01 0.463 0 0
Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 R-HSA-9916720 3.440284e-01 0.463 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.440284e-01 0.463 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.440284e-01 0.463 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.440284e-01 0.463 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.440284e-01 0.463 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.440284e-01 0.463 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.440284e-01 0.463 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.440284e-01 0.463 0 0
Intestinal infectious diseases R-HSA-8942233 3.440284e-01 0.463 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.098554e-01 0.509 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.098554e-01 0.509 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.098554e-01 0.509 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.098554e-01 0.509 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.300468e-01 0.366 0 0
Defective UGT1A4 causes hyperbilirubinemia R-HSA-5579016 4.300468e-01 0.366 0 0
Defective F8 sulfation at Y1699 R-HSA-9674519 4.300468e-01 0.366 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.300468e-01 0.366 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.300468e-01 0.366 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.300468e-01 0.366 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.300468e-01 0.366 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 4.300468e-01 0.366 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.300468e-01 0.366 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 3.606814e-01 0.443 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.606814e-01 0.443 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.606814e-01 0.443 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.145128e-01 0.502 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.104081e-01 0.508 0 0
Phosphorylation of the APC/C R-HSA-176412 3.104081e-01 0.508 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.525398e-01 0.453 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.100488e-01 0.387 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.100488e-01 0.387 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.100488e-01 0.387 0 0
SOS-mediated signalling R-HSA-112412 4.100488e-01 0.387 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.100488e-01 0.387 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.047899e-01 0.297 0 0
Invadopodia formation R-HSA-8941237 5.047899e-01 0.297 0 0
Defective ABCA1 causes TGD R-HSA-5682113 5.047899e-01 0.297 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.038350e-01 0.517 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.038350e-01 0.517 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.418267e-01 0.466 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.903002e-01 0.409 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.310319e-01 0.480 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.310319e-01 0.480 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.733222e-01 0.428 0 0
RSK activation R-HSA-444257 4.574665e-01 0.340 0 0
Regulation by c-FLIP R-HSA-3371378 4.574665e-01 0.340 0 0
Dimerization of procaspase-8 R-HSA-69416 4.574665e-01 0.340 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.574665e-01 0.340 0 0
Activation of RAS in B cells R-HSA-1169092 4.574665e-01 0.340 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.574665e-01 0.340 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.574665e-01 0.340 0 0
Notch-HLH transcription pathway R-HSA-350054 3.584395e-01 0.446 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.046900e-01 0.393 0 0
PKA activation in glucagon signalling R-HSA-164378 4.046900e-01 0.393 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.859136e-01 0.414 0 0
Dual Incision in GG-NER R-HSA-5696400 3.554569e-01 0.449 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.944341e-01 0.404 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.133186e-01 0.384 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.638301e-01 0.334 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.638301e-01 0.334 0 0
WNT mediated activation of DVL R-HSA-201688 5.025970e-01 0.299 0 0
CASP8 activity is inhibited R-HSA-5218900 5.025970e-01 0.299 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 5.025970e-01 0.299 0 0
HCN channels R-HSA-1296061 5.697350e-01 0.244 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.697350e-01 0.244 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.697350e-01 0.244 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.697350e-01 0.244 0 0
Defective MAT1A causes MATD R-HSA-5579024 5.697350e-01 0.244 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.696614e-01 0.432 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.005985e-01 0.397 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.663248e-01 0.331 0 0
Viral mRNA Translation R-HSA-192823 3.422683e-01 0.466 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.991264e-01 0.302 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.141803e-01 0.383 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.452249e-01 0.263 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.452249e-01 0.263 0 0
2-LTR circle formation R-HSA-164843 5.452249e-01 0.263 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.452249e-01 0.263 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.452249e-01 0.263 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.679847e-01 0.330 0 0
Dual incision in TC-NER R-HSA-6782135 4.488705e-01 0.348 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.939183e-01 0.306 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.939183e-01 0.306 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.939183e-01 0.306 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.939183e-01 0.306 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.939183e-01 0.306 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 5.332024e-01 0.273 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 5.332024e-01 0.273 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.499741e-01 0.347 0 0
HIV Transcription Elongation R-HSA-167169 4.900859e-01 0.310 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.900859e-01 0.310 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.900859e-01 0.310 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.900859e-01 0.310 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.884686e-01 0.311 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.869911e-01 0.312 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.199007e-01 0.284 0 0
HIV elongation arrest and recovery R-HSA-167287 5.199007e-01 0.284 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.199007e-01 0.284 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.119052e-01 0.291 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.088393e-01 0.293 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.037978e-01 0.298 0 0
HDACs deacetylate histones R-HSA-3214815 5.251271e-01 0.280 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.452962e-01 0.263 0 0
DNA methylation R-HSA-5334118 5.452962e-01 0.263 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.659271e-01 0.247 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.852305e-01 0.233 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.852305e-01 0.233 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.438309e-01 0.265 0 0
DAP12 signaling R-HSA-2424491 5.700345e-01 0.244 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.972044e-01 0.224 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 5.972044e-01 0.224 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.954981e-01 0.305 0 0
Protein folding R-HSA-391251 5.709648e-01 0.243 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.024035e-01 0.299 0 0
EGFR downregulation R-HSA-182971 4.190772e-01 0.378 0 0
Signaling by SCF-KIT R-HSA-1433557 4.262185e-01 0.370 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.902066e-01 0.229 0 0
Nucleotide Excision Repair R-HSA-5696398 5.769661e-01 0.239 0 0
IGF1R signaling cascade R-HSA-2428924 4.317982e-01 0.365 0 0
Pexophagy R-HSA-9664873 5.452249e-01 0.263 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.633791e-01 0.440 0 0
Telomere Maintenance R-HSA-157579 4.501519e-01 0.347 0 0
Lagging Strand Synthesis R-HSA-69186 3.038350e-01 0.517 0 0
RUNX2 regulates bone development R-HSA-8941326 5.614104e-01 0.251 0 0
Telomere Extension By Telomerase R-HSA-171319 3.451301e-01 0.462 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.191297e-01 0.378 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.488705e-01 0.348 0 0
Ribosome-associated quality control R-HSA-9948299 5.101746e-01 0.292 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.842953e-01 0.415 0 0
Activation of SMO R-HSA-5635838 5.332024e-01 0.273 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.659271e-01 0.247 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.104081e-01 0.508 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.199007e-01 0.284 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.614104e-01 0.251 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.038350e-01 0.517 0 0
Inwardly rectifying K+ channels R-HSA-1296065 4.435892e-01 0.353 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.329487e-01 0.364 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.659271e-01 0.247 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.240119e-01 0.281 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.493882e-01 0.347 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.859136e-01 0.414 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.452249e-01 0.263 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.452249e-01 0.263 0 0
Mitophagy R-HSA-5205647 5.155123e-01 0.288 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.525613e-01 0.258 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.525613e-01 0.258 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.418267e-01 0.466 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.262185e-01 0.370 0 0
RMTs methylate histone arginines R-HSA-3214858 5.953612e-01 0.225 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.098554e-01 0.509 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.100488e-01 0.387 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.178388e-01 0.498 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 4.900859e-01 0.310 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.384863e-01 0.269 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.554569e-01 0.449 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.944341e-01 0.404 0 0
Myogenesis R-HSA-525793 4.674303e-01 0.330 0 0
Signalling to ERKs R-HSA-187687 3.780006e-01 0.423 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.357455e-01 0.361 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.025970e-01 0.299 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.678842e-01 0.330 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 3.903002e-01 0.409 0 0
PKA activation R-HSA-163615 4.046900e-01 0.393 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.357455e-01 0.361 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.025970e-01 0.299 0 0
Regulation of gap junction activity R-HSA-191650 5.697350e-01 0.244 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.800724e-01 0.237 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.800664e-01 0.420 0 0
Host Interactions of HIV factors R-HSA-162909 4.753575e-01 0.323 0 0
Mitochondrial biogenesis R-HSA-1592230 5.697454e-01 0.244 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.633503e-01 0.249 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.633503e-01 0.249 0 0
Repression of WNT target genes R-HSA-4641265 3.903002e-01 0.409 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.425754e-01 0.465 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.425754e-01 0.465 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.842953e-01 0.415 0 0
TCR signaling R-HSA-202403 5.465770e-01 0.262 0 0
Mitotic Prophase R-HSA-68875 4.239681e-01 0.373 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.965690e-01 0.402 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.452249e-01 0.263 0 0
GPER1 signaling R-HSA-9634597 5.289422e-01 0.277 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.980940e-01 0.223 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.024035e-01 0.299 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.728235e-01 0.428 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.024035e-01 0.299 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.411600e-01 0.267 0 0
Abacavir transmembrane transport R-HSA-2161517 3.606814e-01 0.443 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 4.100488e-01 0.387 0 0
Ca2+ activated K+ channels R-HSA-1296052 4.100488e-01 0.387 0 0
mRNA Editing: C to U Conversion R-HSA-72200 4.100488e-01 0.387 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.574665e-01 0.340 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.574665e-01 0.340 0 0
Josephin domain DUBs R-HSA-5689877 5.452249e-01 0.263 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.228293e-01 0.374 0 0
Formation of the posterior neural plate R-HSA-9832991 5.852305e-01 0.233 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.544879e-01 0.256 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.411600e-01 0.267 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.972044e-01 0.224 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.972044e-01 0.224 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.645668e-01 0.333 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.806432e-01 0.236 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.645668e-01 0.333 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.645668e-01 0.333 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.842953e-01 0.415 0 0
Triglyceride catabolism R-HSA-163560 5.614104e-01 0.251 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.108480e-01 0.507 0 0
Cellular response to starvation R-HSA-9711097 4.258004e-01 0.371 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.903002e-01 0.409 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.025970e-01 0.299 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.395645e-01 0.268 0 0
Hedgehog 'off' state R-HSA-5610787 5.948326e-01 0.226 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.553060e-01 0.255 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.155123e-01 0.288 0 0
Leukotriene receptors R-HSA-391906 3.606814e-01 0.443 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.108480e-01 0.507 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.697350e-01 0.244 0 0
Mitochondrial protein degradation R-HSA-9837999 2.990586e-01 0.524 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.734925e-01 0.428 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.734925e-01 0.428 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.940559e-01 0.226 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.815513e-01 0.418 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 3.697524e-01 0.432 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.932682e-01 0.405 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.370335e-01 0.359 0 0
Interleukin-2 family signaling R-HSA-451927 3.425754e-01 0.465 0 0
Ca2+ pathway R-HSA-4086398 4.664886e-01 0.331 0 0
Signaling by NOTCH4 R-HSA-9013694 4.831552e-01 0.316 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.725222e-01 0.242 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.678842e-01 0.330 0 0
PERK regulates gene expression R-HSA-381042 5.387076e-01 0.269 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.673326e-01 0.330 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.494897e-01 0.347 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 3.733222e-01 0.428 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.584395e-01 0.446 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.317102e-01 0.479 0 0
Cell junction organization R-HSA-446728 3.911842e-01 0.408 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.440284e-01 0.463 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.098554e-01 0.509 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.098554e-01 0.509 0 0
Formation of the Editosome R-HSA-75094 3.098554e-01 0.509 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.300468e-01 0.366 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.300468e-01 0.366 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 4.300468e-01 0.366 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.100488e-01 0.387 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.100488e-01 0.387 0 0
Disorders of Developmental Biology R-HSA-9675151 3.418267e-01 0.466 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.574665e-01 0.340 0 0
Co-stimulation by ICOS R-HSA-9927354 4.574665e-01 0.340 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.274836e-01 0.369 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.046900e-01 0.393 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.025970e-01 0.299 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.697350e-01 0.244 0 0
Alanine metabolism R-HSA-8964540 5.697350e-01 0.244 0 0
Transmission across Electrical Synapses R-HSA-112307 5.697350e-01 0.244 0 0
Dopamine receptors R-HSA-390651 5.697350e-01 0.244 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.697350e-01 0.244 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.697350e-01 0.244 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.405291e-01 0.356 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.155123e-01 0.288 0 0
Intraflagellar transport R-HSA-5620924 5.289422e-01 0.277 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.452962e-01 0.263 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 5.852305e-01 0.233 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.852305e-01 0.233 0 0
Base Excision Repair R-HSA-73884 5.265769e-01 0.279 0 0
Cell-Cell communication R-HSA-1500931 3.083684e-01 0.511 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.615096e-01 0.442 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 5.813157e-01 0.236 0 0
Signaling by NTRKs R-HSA-166520 3.160182e-01 0.500 0 0
Regulation of beta-cell development R-HSA-186712 3.441346e-01 0.463 0 0
Platelet degranulation R-HSA-114608 4.369505e-01 0.360 0 0
Amine ligand-binding receptors R-HSA-375280 4.471080e-01 0.350 0 0
Transport of RCbl within the body R-HSA-9758890 5.852305e-01 0.233 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.574665e-01 0.340 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.697350e-01 0.244 0 0
TBC/RABGAPs R-HSA-8854214 4.262185e-01 0.370 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.452249e-01 0.263 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.452962e-01 0.263 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.659271e-01 0.247 0 0
FLT3 signaling in disease R-HSA-9682385 5.614104e-01 0.251 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 4.100488e-01 0.387 0 0
Gap junction trafficking R-HSA-190828 3.116656e-01 0.506 0 0
Signal regulatory protein family interactions R-HSA-391160 4.638301e-01 0.334 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.697350e-01 0.244 0 0
Glucose metabolism R-HSA-70326 3.021406e-01 0.520 0 0
LGI-ADAM interactions R-HSA-5682910 5.852305e-01 0.233 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.206704e-01 0.494 0 0
Hemostasis R-HSA-109582 3.323304e-01 0.478 0 0
Generation of second messenger molecules R-HSA-202433 4.900859e-01 0.310 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.412667e-01 0.267 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.525613e-01 0.258 0 0
Alpha-defensins R-HSA-1462054 4.574665e-01 0.340 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.025970e-01 0.299 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.052617e-01 0.392 0 0
LTC4-CYSLTR mediated IL4 production R-HSA-9664535 5.452249e-01 0.263 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.061685e-01 0.296 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.852305e-01 0.233 0 0
Synthesis of PI R-HSA-1483226 5.852305e-01 0.233 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.939183e-01 0.306 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.133186e-01 0.384 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.274836e-01 0.369 0 0
Carnitine shuttle R-HSA-200425 5.813157e-01 0.236 0 0
Other interleukin signaling R-HSA-449836 4.357455e-01 0.361 0 0
Histamine receptors R-HSA-390650 5.047899e-01 0.297 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.025970e-01 0.299 0 0
Selenocysteine synthesis R-HSA-2408557 3.161576e-01 0.500 0 0
Signaling by Interleukins R-HSA-449147 4.629507e-01 0.334 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.352277e-01 0.361 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.300468e-01 0.366 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.025970e-01 0.299 0 0
Maturation of spike protein R-HSA-9683686 5.452249e-01 0.263 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.155123e-01 0.288 0 0
PI Metabolism R-HSA-1483255 4.221116e-01 0.375 0 0
Influenza Infection R-HSA-168255 5.884086e-01 0.230 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.098554e-01 0.509 0 0
FasL/ CD95L signaling R-HSA-75157 5.047899e-01 0.297 0 0
Nephron development R-HSA-9831926 4.046900e-01 0.393 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.328216e-01 0.478 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.655558e-01 0.332 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.108480e-01 0.507 0 0
Growth hormone receptor signaling R-HSA-982772 5.813157e-01 0.236 0 0
IRE1alpha activates chaperones R-HSA-381070 5.563371e-01 0.255 0 0
Interleukin-12 signaling R-HSA-9020591 5.161459e-01 0.287 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.357455e-01 0.361 0 0
Interleukin-1 family signaling R-HSA-446652 6.005421e-01 0.221 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.005421e-01 0.221 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 6.013799e-01 0.221 0 0
Signaling by ERBB4 R-HSA-1236394 6.013799e-01 0.221 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.051405e-01 0.218 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.058961e-01 0.218 0 0
Vesicle-mediated transport R-HSA-5653656 6.073480e-01 0.217 0 0
PTEN Regulation R-HSA-6807070 6.076148e-01 0.216 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.077586e-01 0.216 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.077586e-01 0.216 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.077586e-01 0.216 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.084581e-01 0.216 0 0
Adaptive Immune System R-HSA-1280218 6.103395e-01 0.214 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.136457e-01 0.212 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.150621e-01 0.211 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.150621e-01 0.211 0 0
DNA strand elongation R-HSA-69190 6.173112e-01 0.209 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.173112e-01 0.209 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.225683e-01 0.206 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 6.225683e-01 0.206 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.225683e-01 0.206 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.225683e-01 0.206 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.225683e-01 0.206 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.225683e-01 0.206 0 0
Integration of provirus R-HSA-162592 6.225683e-01 0.206 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.241068e-01 0.205 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.260861e-01 0.203 0 0
Stabilization of p53 R-HSA-69541 6.260861e-01 0.203 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.261661e-01 0.203 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 6.261661e-01 0.203 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.261661e-01 0.203 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.261661e-01 0.203 0 0
Defective F9 activation R-HSA-9673221 6.261661e-01 0.203 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.261661e-01 0.203 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.261661e-01 0.203 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.261661e-01 0.203 0 0
Activation of AKT2 R-HSA-165158 6.261661e-01 0.203 0 0
Suppression of autophagy R-HSA-9636569 6.261661e-01 0.203 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.261661e-01 0.203 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.261661e-01 0.203 0 0
Inositol transporters R-HSA-429593 6.261661e-01 0.203 0 0
Co-inhibition by BTLA R-HSA-9927353 6.261661e-01 0.203 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.261661e-01 0.203 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.261661e-01 0.203 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.261661e-01 0.203 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 6.269687e-01 0.203 0 0
Platelet sensitization by LDL R-HSA-432142 6.269687e-01 0.203 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.324852e-01 0.199 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.331516e-01 0.198 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.331516e-01 0.198 0 0
G protein gated Potassium channels R-HSA-1296059 6.331516e-01 0.198 0 0
Tight junction interactions R-HSA-420029 6.331516e-01 0.198 0 0
PPARA activates gene expression R-HSA-1989781 6.331979e-01 0.198 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.397606e-01 0.194 0 0
Nuclear RNA decay R-HSA-9930044 6.397606e-01 0.194 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.397606e-01 0.194 0 0
Cardiogenesis R-HSA-9733709 6.397606e-01 0.194 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.451539e-01 0.190 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.463751e-01 0.190 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.463751e-01 0.190 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.463751e-01 0.190 0 0
Glycogen metabolism R-HSA-8982491 6.463751e-01 0.190 0 0
Gastrulation R-HSA-9758941 6.479766e-01 0.188 0 0
Heme signaling R-HSA-9707616 6.490307e-01 0.188 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 6.542615e-01 0.184 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.551812e-01 0.184 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.551812e-01 0.184 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.558237e-01 0.183 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.572499e-01 0.182 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.572499e-01 0.182 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.572499e-01 0.182 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.572499e-01 0.182 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 6.572499e-01 0.182 0 0
Regulation of IFNG signaling R-HSA-877312 6.572499e-01 0.182 0 0
Pervasive developmental disorders R-HSA-9005895 6.572499e-01 0.182 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.572499e-01 0.182 0 0
Disorders of Nervous System Development R-HSA-9697154 6.572499e-01 0.182 0 0
Interleukin-15 signaling R-HSA-8983432 6.572499e-01 0.182 0 0
Estrogen biosynthesis R-HSA-193144 6.572499e-01 0.182 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.572499e-01 0.182 0 0
OAS antiviral response R-HSA-8983711 6.572499e-01 0.182 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 6.574576e-01 0.182 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.574576e-01 0.182 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.613733e-01 0.180 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.613733e-01 0.180 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.613733e-01 0.180 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.613733e-01 0.180 0 0
RNA Polymerase I Transcription R-HSA-73864 6.622805e-01 0.179 0 0
Interferon Signaling R-HSA-913531 6.638206e-01 0.178 0 0
Regulation of insulin secretion R-HSA-422356 6.672480e-01 0.176 0 0
NGF-stimulated transcription R-HSA-9031628 6.708815e-01 0.173 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.732115e-01 0.172 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.751988e-01 0.171 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.751988e-01 0.171 0 0
PDE3B signalling R-HSA-165160 6.751988e-01 0.171 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.751988e-01 0.171 0 0
PKB-mediated events R-HSA-109703 6.751988e-01 0.171 0 0
Signaling by MAPK mutants R-HSA-9652817 6.751988e-01 0.171 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.751988e-01 0.171 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.751988e-01 0.171 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.751988e-01 0.171 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.751988e-01 0.171 0 0
NGF-independant TRKA activation R-HSA-187024 6.751988e-01 0.171 0 0
Phosphorylation of Emi1 R-HSA-176417 6.751988e-01 0.171 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.751988e-01 0.171 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.751988e-01 0.171 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.751988e-01 0.171 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.751988e-01 0.171 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.751988e-01 0.171 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.751988e-01 0.171 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.751988e-01 0.171 0 0
TRAIL signaling R-HSA-75158 6.751988e-01 0.171 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.751988e-01 0.171 0 0
Signaling by EGFR R-HSA-177929 6.758774e-01 0.170 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.778195e-01 0.169 0 0
Packaging Of Telomere Ends R-HSA-171306 6.806525e-01 0.167 0 0
Cristae formation R-HSA-8949613 6.806525e-01 0.167 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.806525e-01 0.167 0 0
Insulin receptor signalling cascade R-HSA-74751 6.808707e-01 0.167 0 0
rRNA processing R-HSA-72312 6.817658e-01 0.166 0 0
Protein hydroxylation R-HSA-9629569 6.818257e-01 0.166 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.821271e-01 0.166 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.821271e-01 0.166 0 0
Nuclear import of Rev protein R-HSA-180746 6.821271e-01 0.166 0 0
Signaling by NOTCH2 R-HSA-1980145 6.821271e-01 0.166 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.821271e-01 0.166 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.848889e-01 0.164 0 0
Translation of Structural Proteins R-HSA-9683701 6.848889e-01 0.164 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.858086e-01 0.164 0 0
Signaling by NOTCH R-HSA-157118 6.867102e-01 0.163 0 0
Adherens junctions interactions R-HSA-418990 6.887548e-01 0.162 0 0
Acetylcholine binding and downstream events R-HSA-181431 6.893297e-01 0.162 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 6.893297e-01 0.162 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.893297e-01 0.162 0 0
Processing of SMDT1 R-HSA-8949664 6.893297e-01 0.162 0 0
FGFR1c ligand binding and activation R-HSA-190373 6.893297e-01 0.162 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.893297e-01 0.162 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.893486e-01 0.162 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.906623e-01 0.161 0 0
Interleukin-12 family signaling R-HSA-447115 6.954169e-01 0.158 0 0
Cilium Assembly R-HSA-5617833 6.954703e-01 0.158 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.027242e-01 0.153 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.027242e-01 0.153 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.030807e-01 0.153 0 0
Depyrimidination R-HSA-73928 7.030807e-01 0.153 0 0
Amyloid fiber formation R-HSA-977225 7.042983e-01 0.152 0 0
PI3K Cascade R-HSA-109704 7.051632e-01 0.152 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.069053e-01 0.151 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.069053e-01 0.151 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.069053e-01 0.151 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.069053e-01 0.151 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.069053e-01 0.151 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.069053e-01 0.151 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.090350e-01 0.149 0 0
Cell-cell junction organization R-HSA-421270 7.150903e-01 0.146 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.178027e-01 0.144 0 0
STAT5 Activation R-HSA-9645135 7.178027e-01 0.144 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.178027e-01 0.144 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.178027e-01 0.144 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.178027e-01 0.144 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.178027e-01 0.144 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.178027e-01 0.144 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.178027e-01 0.144 0 0
NADPH regeneration R-HSA-389542 7.178027e-01 0.144 0 0
Neurofascin interactions R-HSA-447043 7.178027e-01 0.144 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 7.178027e-01 0.144 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.188936e-01 0.143 0 0
Removal of the Flap Intermediate R-HSA-69166 7.188936e-01 0.143 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 7.188936e-01 0.143 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 7.188936e-01 0.143 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 7.188936e-01 0.143 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.188936e-01 0.143 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.204302e-01 0.142 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.204302e-01 0.142 0 0
Signaling by FGFR4 R-HSA-5654743 7.205490e-01 0.142 0 0
Defective pyroptosis R-HSA-9710421 7.205490e-01 0.142 0 0
Signaling by Erythropoietin R-HSA-9006335 7.236708e-01 0.140 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.236708e-01 0.140 0 0
Late endosomal microautophagy R-HSA-9615710 7.236708e-01 0.140 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.236708e-01 0.140 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.276956e-01 0.138 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.304392e-01 0.136 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.304392e-01 0.136 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.315446e-01 0.136 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.315446e-01 0.136 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.358004e-01 0.133 0 0
GABA receptor activation R-HSA-977443 7.376783e-01 0.132 0 0
Cleavage of the damaged purine R-HSA-110331 7.391233e-01 0.131 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.434993e-01 0.129 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.460494e-01 0.127 0 0
Erythropoietin activates RAS R-HSA-9027284 7.460494e-01 0.127 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.460494e-01 0.127 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.460494e-01 0.127 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.460494e-01 0.127 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.460494e-01 0.127 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 7.460494e-01 0.127 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.460494e-01 0.127 0 0
p75NTR signals via NF-kB R-HSA-193639 7.460494e-01 0.127 0 0
Protein methylation R-HSA-8876725 7.460494e-01 0.127 0 0
Biotin transport and metabolism R-HSA-196780 7.460494e-01 0.127 0 0
Developmental Cell Lineages R-HSA-9734767 7.484153e-01 0.126 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.517843e-01 0.124 0 0
MAP kinase activation R-HSA-450294 7.517843e-01 0.124 0 0
Aquaporin-mediated transport R-HSA-445717 7.517843e-01 0.124 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.519763e-01 0.124 0 0
FGFR2 alternative splicing R-HSA-6803529 7.524595e-01 0.124 0 0
Ethanol oxidation R-HSA-71384 7.524595e-01 0.124 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.533024e-01 0.123 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.533024e-01 0.123 0 0
Signaling by FGFR3 R-HSA-5654741 7.533024e-01 0.123 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.533024e-01 0.123 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.533024e-01 0.123 0 0
Translation of Structural Proteins R-HSA-9694635 7.534857e-01 0.123 0 0
Signaling by Hedgehog R-HSA-5358351 7.546311e-01 0.122 0 0
Netrin mediated repulsion signals R-HSA-418886 7.548205e-01 0.122 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.548205e-01 0.122 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.548205e-01 0.122 0 0
Disinhibition of SNARE formation R-HSA-114516 7.548205e-01 0.122 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.548205e-01 0.122 0 0
Recycling of eIF2:GDP R-HSA-72731 7.548205e-01 0.122 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.548205e-01 0.122 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.548205e-01 0.122 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.548205e-01 0.122 0 0
VLDL clearance R-HSA-8964046 7.548205e-01 0.122 0 0
Activation of TRKA receptors R-HSA-187015 7.548205e-01 0.122 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.548205e-01 0.122 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.548205e-01 0.122 0 0
Maturation of replicase proteins R-HSA-9694301 7.548205e-01 0.122 0 0
Depurination R-HSA-73927 7.563620e-01 0.121 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.622246e-01 0.118 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.631721e-01 0.117 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.652288e-01 0.116 0 0
PCP/CE pathway R-HSA-4086400 7.657315e-01 0.116 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.663402e-01 0.116 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.675215e-01 0.115 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.709202e-01 0.113 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.709202e-01 0.113 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.709202e-01 0.113 0 0
Killing mechanisms R-HSA-9664420 7.709202e-01 0.113 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.709202e-01 0.113 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.709202e-01 0.113 0 0
Regulation of BACH1 activity R-HSA-9708530 7.709202e-01 0.113 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.709202e-01 0.113 0 0
Atorvastatin ADME R-HSA-9754706 7.709202e-01 0.113 0 0
Differentiation of T cells R-HSA-9945266 7.709202e-01 0.113 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.709202e-01 0.113 0 0
Negative regulation of FLT3 R-HSA-9706369 7.709202e-01 0.113 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.709202e-01 0.113 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.727320e-01 0.112 0 0
Termination of O-glycan biosynthesis R-HSA-977068 7.730089e-01 0.112 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.777029e-01 0.109 0 0
Co-inhibition by PD-1 R-HSA-389948 7.777832e-01 0.109 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.788168e-01 0.109 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.788168e-01 0.109 0 0
Signaling by NOTCH3 R-HSA-9012852 7.800878e-01 0.108 0 0
Synthesis of DNA R-HSA-69239 7.812872e-01 0.107 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.831629e-01 0.106 0 0
GPCR downstream signalling R-HSA-388396 7.860374e-01 0.105 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.869843e-01 0.104 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.869843e-01 0.104 0 0
Formation of annular gap junctions R-HSA-196025 7.869843e-01 0.104 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.869843e-01 0.104 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.869843e-01 0.104 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.869843e-01 0.104 0 0
Interleukin-9 signaling R-HSA-8985947 7.869843e-01 0.104 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.869843e-01 0.104 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.869843e-01 0.104 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.869843e-01 0.104 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.869843e-01 0.104 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.869843e-01 0.104 0 0
Sodium/Proton exchangers R-HSA-425986 7.869843e-01 0.104 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.882468e-01 0.103 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.882468e-01 0.103 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.895177e-01 0.103 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.895177e-01 0.103 0 0
G alpha (s) signalling events R-HSA-418555 7.904051e-01 0.102 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.921382e-01 0.101 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.921382e-01 0.101 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.921382e-01 0.101 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.921936e-01 0.101 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.932252e-01 0.101 0 0
Signaling by FGFR1 R-HSA-5654736 7.932252e-01 0.101 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.932252e-01 0.101 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.936381e-01 0.100 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.936381e-01 0.100 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.936381e-01 0.100 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.936381e-01 0.100 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 7.936381e-01 0.100 0 0
Phase 2 - plateau phase R-HSA-5576893 7.936381e-01 0.100 0 0
Passive transport by Aquaporins R-HSA-432047 7.936381e-01 0.100 0 0
tRNA modification in the mitochondrion R-HSA-6787450 7.936381e-01 0.100 0 0
Synthesis of PG R-HSA-1483148 7.936381e-01 0.100 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 7.936381e-01 0.100 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.964570e-01 0.099 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.964570e-01 0.099 0 0
Metal ion SLC transporters R-HSA-425410 7.970279e-01 0.099 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.009485e-01 0.096 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.017393e-01 0.096 0 0
Cellular response to hypoxia R-HSA-1234174 8.028163e-01 0.095 0 0
Maturation of spike protein R-HSA-9694548 8.029238e-01 0.095 0 0
Regulation of CDH1 Function R-HSA-9764561 8.057608e-01 0.094 0 0
IRS-mediated signalling R-HSA-112399 8.057608e-01 0.094 0 0
Nuclear Envelope Breakdown R-HSA-2980766 8.057608e-01 0.094 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.099046e-01 0.092 0 0
Degradation of CDH1 R-HSA-9766229 8.101989e-01 0.091 0 0
Signaling by FGFR in disease R-HSA-1226099 8.119102e-01 0.090 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.120222e-01 0.090 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.120222e-01 0.090 0 0
HIV Infection R-HSA-162906 8.122955e-01 0.090 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.125845e-01 0.090 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.143397e-01 0.089 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.143397e-01 0.089 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.143397e-01 0.089 0 0
Sulfide oxidation to sulfate R-HSA-1614517 8.143397e-01 0.089 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.143397e-01 0.089 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.143397e-01 0.089 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.143397e-01 0.089 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.149303e-01 0.089 0 0
Gap junction degradation R-HSA-190873 8.149303e-01 0.089 0 0
Calcineurin activates NFAT R-HSA-2025928 8.149303e-01 0.089 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.149303e-01 0.089 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 8.149303e-01 0.089 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.149303e-01 0.089 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.149303e-01 0.089 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.149303e-01 0.089 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.149303e-01 0.089 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 8.149303e-01 0.089 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 8.149303e-01 0.089 0 0
Lipophagy R-HSA-9613354 8.149303e-01 0.089 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.149303e-01 0.089 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 8.149303e-01 0.089 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.149303e-01 0.089 0 0
Intra-Golgi traffic R-HSA-6811438 8.167835e-01 0.088 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.167835e-01 0.088 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.167835e-01 0.088 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.167835e-01 0.088 0 0
Downstream TCR signaling R-HSA-202424 8.192826e-01 0.087 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.205394e-01 0.086 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.224092e-01 0.085 0 0
DNA Replication R-HSA-69306 8.227376e-01 0.085 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.263696e-01 0.083 0 0
Abacavir ADME R-HSA-2161522 8.263696e-01 0.083 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 8.263696e-01 0.083 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.265989e-01 0.083 0 0
Metabolism of non-coding RNA R-HSA-194441 8.290688e-01 0.081 0 0
snRNP Assembly R-HSA-191859 8.290688e-01 0.081 0 0
Triglyceride metabolism R-HSA-8979227 8.290688e-01 0.081 0 0
Activation of GABAB receptors R-HSA-991365 8.298492e-01 0.081 0 0
GABA B receptor activation R-HSA-977444 8.298492e-01 0.081 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.302076e-01 0.081 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.331631e-01 0.079 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 8.331631e-01 0.079 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.331631e-01 0.079 0 0
Mismatch Repair R-HSA-5358508 8.331631e-01 0.079 0 0
Tie2 Signaling R-HSA-210993 8.331631e-01 0.079 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.345210e-01 0.079 0 0
Binding and entry of HIV virion R-HSA-173107 8.392113e-01 0.076 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.392113e-01 0.076 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.392113e-01 0.076 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.392113e-01 0.076 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.392113e-01 0.076 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.392113e-01 0.076 0 0
Metabolism of serotonin R-HSA-380612 8.392113e-01 0.076 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.392113e-01 0.076 0 0
Arachidonate production from DAG R-HSA-426048 8.392113e-01 0.076 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.392113e-01 0.076 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.392113e-01 0.076 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.392113e-01 0.076 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.392113e-01 0.076 0 0
Serotonin receptors R-HSA-390666 8.392113e-01 0.076 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.398665e-01 0.076 0 0
Signaling by Retinoic Acid R-HSA-5362517 8.398665e-01 0.076 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.402248e-01 0.076 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.402248e-01 0.076 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.415975e-01 0.075 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.415975e-01 0.075 0 0
Signaling by BMP R-HSA-201451 8.415975e-01 0.075 0 0
Selenoamino acid metabolism R-HSA-2408522 8.442078e-01 0.074 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.457077e-01 0.073 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.457077e-01 0.073 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.457077e-01 0.073 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.457077e-01 0.073 0 0
G alpha (q) signalling events R-HSA-416476 8.476205e-01 0.072 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.502446e-01 0.070 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.502446e-01 0.070 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.502446e-01 0.070 0 0
Regulation of signaling by CBL R-HSA-912631 8.502446e-01 0.070 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.502446e-01 0.070 0 0
Diseases of hemostasis R-HSA-9671793 8.502446e-01 0.070 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.502446e-01 0.070 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.529395e-01 0.069 0 0
DAP12 interactions R-HSA-2172127 8.537009e-01 0.069 0 0
Interleukin-17 signaling R-HSA-448424 8.549380e-01 0.068 0 0
Leishmania infection R-HSA-9658195 8.553271e-01 0.068 0 0
Parasitic Infection Pathways R-HSA-9824443 8.553271e-01 0.068 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.556545e-01 0.068 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.556545e-01 0.068 0 0
Potential therapeutics for SARS R-HSA-9679191 8.561849e-01 0.067 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.562709e-01 0.067 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.598226e-01 0.066 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.603080e-01 0.065 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.603080e-01 0.065 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.603080e-01 0.065 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.603080e-01 0.065 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.603080e-01 0.065 0 0
Bicarbonate transporters R-HSA-425381 8.603080e-01 0.065 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.603080e-01 0.065 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.603080e-01 0.065 0 0
Suppression of apoptosis R-HSA-9635465 8.603080e-01 0.065 0 0
Interleukin-1 signaling R-HSA-9020702 8.604507e-01 0.065 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.647843e-01 0.063 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.647843e-01 0.063 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.657173e-01 0.063 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.657173e-01 0.063 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.657173e-01 0.063 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.657173e-01 0.063 0 0
Signaling by FGFR2 R-HSA-5654738 8.682637e-01 0.061 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.686075e-01 0.061 0 0
Toll-like Receptor Cascades R-HSA-168898 8.693792e-01 0.061 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.724200e-01 0.059 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.746995e-01 0.058 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.746995e-01 0.058 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.756122e-01 0.058 0 0
G alpha (z) signalling events R-HSA-418597 8.756122e-01 0.058 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.758010e-01 0.058 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.758010e-01 0.058 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.786377e-01 0.056 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.786377e-01 0.056 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.786377e-01 0.056 0 0
Plasmalogen biosynthesis R-HSA-75896 8.786377e-01 0.056 0 0
NF-kB is activated and signals survival R-HSA-209560 8.786377e-01 0.056 0 0
ERKs are inactivated R-HSA-202670 8.786377e-01 0.056 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.786377e-01 0.056 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.786377e-01 0.056 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.786377e-01 0.056 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.786377e-01 0.056 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.797090e-01 0.056 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.797090e-01 0.056 0 0
Signalling to RAS R-HSA-167044 8.797090e-01 0.056 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.797090e-01 0.056 0 0
ERK/MAPK targets R-HSA-198753 8.797090e-01 0.056 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.797090e-01 0.056 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 8.805229e-01 0.055 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.805229e-01 0.055 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.805229e-01 0.055 0 0
Neurotransmitter clearance R-HSA-112311 8.805229e-01 0.055 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.805229e-01 0.055 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.805229e-01 0.055 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.816768e-01 0.055 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.817888e-01 0.055 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.842021e-01 0.053 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.848326e-01 0.053 0 0
Pentose phosphate pathway R-HSA-71336 8.860320e-01 0.053 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.860320e-01 0.053 0 0
Inositol phosphate metabolism R-HSA-1483249 8.860431e-01 0.053 0 0
Downstream signal transduction R-HSA-186763 8.914664e-01 0.050 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.914664e-01 0.050 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.914664e-01 0.050 0 0
Cargo concentration in the ER R-HSA-5694530 8.914664e-01 0.050 0 0
Budding and maturation of HIV virion R-HSA-162588 8.914664e-01 0.050 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.923421e-01 0.049 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.923421e-01 0.049 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.923421e-01 0.049 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.923421e-01 0.049 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 8.923421e-01 0.049 0 0
Gluconeogenesis R-HSA-70263 8.930803e-01 0.049 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.938292e-01 0.049 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.945631e-01 0.048 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 8.945631e-01 0.048 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 8.945631e-01 0.048 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.945631e-01 0.048 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.945631e-01 0.048 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.945631e-01 0.048 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.945631e-01 0.048 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.945631e-01 0.048 0 0
MET activates RAS signaling R-HSA-8851805 8.945631e-01 0.048 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.945631e-01 0.048 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.945631e-01 0.048 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.945631e-01 0.048 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.953705e-01 0.048 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.955194e-01 0.048 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.955194e-01 0.048 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.962155e-01 0.048 0 0
Kidney development R-HSA-9830369 9.009313e-01 0.045 0 0
UCH proteinases R-HSA-5689603 9.022071e-01 0.045 0 0
Signaling by KIT in disease R-HSA-9669938 9.037320e-01 0.044 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.037320e-01 0.044 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.037320e-01 0.044 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.037320e-01 0.044 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.037320e-01 0.044 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.037320e-01 0.044 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.037320e-01 0.044 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.037320e-01 0.044 0 0
LDL clearance R-HSA-8964038 9.037320e-01 0.044 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.037320e-01 0.044 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.060509e-01 0.043 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.062182e-01 0.043 0 0
Transcription of the HIV genome R-HSA-167172 9.077908e-01 0.042 0 0
Regulated Necrosis R-HSA-5218859 9.077908e-01 0.042 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 9.083996e-01 0.042 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.083996e-01 0.042 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 9.083996e-01 0.042 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.083996e-01 0.042 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.083996e-01 0.042 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.083996e-01 0.042 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.083996e-01 0.042 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.083996e-01 0.042 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.083996e-01 0.042 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.083996e-01 0.042 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.083996e-01 0.042 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 9.083996e-01 0.042 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.083996e-01 0.042 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.090842e-01 0.041 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.106035e-01 0.041 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 9.106921e-01 0.041 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.139875e-01 0.039 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.139875e-01 0.039 0 0
Interleukin-20 family signaling R-HSA-8854691 9.139875e-01 0.039 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.139875e-01 0.039 0 0
The phototransduction cascade R-HSA-2514856 9.162695e-01 0.038 0 0
Immune System R-HSA-168256 9.183832e-01 0.037 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 9.190962e-01 0.037 0 0
Heme degradation R-HSA-189483 9.190962e-01 0.037 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.202949e-01 0.036 0 0
COPII-mediated vesicle transport R-HSA-204005 9.202949e-01 0.036 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.204210e-01 0.036 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.204210e-01 0.036 0 0
CRMPs in Sema3A signaling R-HSA-399956 9.204210e-01 0.036 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.204210e-01 0.036 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.204210e-01 0.036 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.204210e-01 0.036 0 0
Signaling by FGFR4 in disease R-HSA-5655291 9.204210e-01 0.036 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 9.204210e-01 0.036 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.204210e-01 0.036 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.204210e-01 0.036 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.204210e-01 0.036 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 9.204210e-01 0.036 0 0
Prolactin receptor signaling R-HSA-1170546 9.204210e-01 0.036 0 0
Malate-aspartate shuttle R-HSA-9856872 9.204210e-01 0.036 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.204210e-01 0.036 0 0
Ciprofloxacin ADME R-HSA-9793528 9.204210e-01 0.036 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.204210e-01 0.036 0 0
P2Y receptors R-HSA-417957 9.204210e-01 0.036 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.204210e-01 0.036 0 0
Orc1 removal from chromatin R-HSA-68949 9.229495e-01 0.035 0 0
Complex III assembly R-HSA-9865881 9.232100e-01 0.035 0 0
Circadian clock R-HSA-9909396 9.235011e-01 0.035 0 0
Hedgehog 'on' state R-HSA-5632684 9.259760e-01 0.033 0 0
RA biosynthesis pathway R-HSA-5365859 9.267718e-01 0.033 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.267718e-01 0.033 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.298472e-01 0.032 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.308654e-01 0.031 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.308654e-01 0.031 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.308654e-01 0.031 0 0
Protein lipoylation R-HSA-9857492 9.308654e-01 0.031 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 9.308654e-01 0.031 0 0
p38MAPK events R-HSA-171007 9.308654e-01 0.031 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.308654e-01 0.031 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 9.308654e-01 0.031 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.308654e-01 0.031 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.308654e-01 0.031 0 0
DNA Damage Reversal R-HSA-73942 9.308654e-01 0.031 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.314940e-01 0.031 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.314940e-01 0.031 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.314940e-01 0.031 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.314940e-01 0.031 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 9.314940e-01 0.031 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 9.314940e-01 0.031 0 0
Formation of the nephric duct R-HSA-9830364 9.314940e-01 0.031 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.332340e-01 0.030 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.337734e-01 0.030 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.342878e-01 0.030 0 0
Neurotransmitter release cycle R-HSA-112310 9.358136e-01 0.029 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.371501e-01 0.028 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.389270e-01 0.027 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.389270e-01 0.027 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.389270e-01 0.027 0 0
Sphingolipid catabolism R-HSA-9845614 9.389270e-01 0.027 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.389270e-01 0.027 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.391038e-01 0.027 0 0
SARS-CoV Infections R-HSA-9679506 9.391468e-01 0.027 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.399395e-01 0.027 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.399395e-01 0.027 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 9.399395e-01 0.027 0 0
Fructose catabolism R-HSA-70350 9.399395e-01 0.027 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.399395e-01 0.027 0 0
Attachment and Entry R-HSA-9678110 9.399395e-01 0.027 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.401527e-01 0.027 0 0
RNA Polymerase III Transcription R-HSA-74158 9.401527e-01 0.027 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.401527e-01 0.027 0 0
Signaling by FGFR R-HSA-190236 9.404284e-01 0.027 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.444998e-01 0.025 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.444998e-01 0.025 0 0
Protein ubiquitination R-HSA-8852135 9.453082e-01 0.024 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.455895e-01 0.024 0 0
Insulin processing R-HSA-264876 9.455895e-01 0.024 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.455895e-01 0.024 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.459585e-01 0.024 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.478231e-01 0.023 0 0
Glycine degradation R-HSA-6783984 9.478231e-01 0.023 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.478231e-01 0.023 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.478231e-01 0.023 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.478231e-01 0.023 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.478231e-01 0.023 0 0
Galactose catabolism R-HSA-70370 9.478231e-01 0.023 0 0
Signaling by Insulin receptor R-HSA-74752 9.479464e-01 0.023 0 0
Cellular response to chemical stress R-HSA-9711123 9.480794e-01 0.023 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.482793e-01 0.023 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.494553e-01 0.023 0 0
MET promotes cell motility R-HSA-8875878 9.512367e-01 0.022 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.515557e-01 0.022 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.515557e-01 0.022 0 0
Prednisone ADME R-HSA-9757110 9.515557e-01 0.022 0 0
Signaling by GPCR R-HSA-372790 9.537348e-01 0.021 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.546723e-01 0.020 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.546723e-01 0.020 0 0
Catecholamine biosynthesis R-HSA-209905 9.546723e-01 0.020 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.546723e-01 0.020 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.546723e-01 0.020 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.555214e-01 0.020 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.560304e-01 0.020 0 0
RAS processing R-HSA-9648002 9.560304e-01 0.020 0 0
HIV Life Cycle R-HSA-162587 9.563207e-01 0.019 0 0
Integrin cell surface interactions R-HSA-216083 9.567147e-01 0.019 0 0
mRNA Capping R-HSA-72086 9.568937e-01 0.019 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.568937e-01 0.019 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.568937e-01 0.019 0 0
Glucagon-type ligand receptors R-HSA-420092 9.568937e-01 0.019 0 0
Peroxisomal protein import R-HSA-9033241 9.578432e-01 0.019 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.578432e-01 0.019 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.600113e-01 0.018 0 0
GAB1 signalosome R-HSA-180292 9.606227e-01 0.017 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.606227e-01 0.017 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.606227e-01 0.017 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.606227e-01 0.017 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.606227e-01 0.017 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.606227e-01 0.017 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.616654e-01 0.017 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.643225e-01 0.016 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.643225e-01 0.016 0 0
ER-Phagosome pathway R-HSA-1236974 9.645866e-01 0.016 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.654728e-01 0.015 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.656684e-01 0.015 0 0
Pyrimidine biosynthesis R-HSA-500753 9.657923e-01 0.015 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.657923e-01 0.015 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.657923e-01 0.015 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.657923e-01 0.015 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.657923e-01 0.015 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.659275e-01 0.015 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.659275e-01 0.015 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.659275e-01 0.015 0 0
Protein localization R-HSA-9609507 9.667404e-01 0.015 0 0
Mitochondrial protein import R-HSA-1268020 9.677791e-01 0.014 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.686626e-01 0.014 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.702834e-01 0.013 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 9.702834e-01 0.013 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 9.702834e-01 0.013 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.702834e-01 0.013 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.702834e-01 0.013 0 0
Creatine metabolism R-HSA-71288 9.702834e-01 0.013 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.702834e-01 0.013 0 0
Pregnenolone biosynthesis R-HSA-196108 9.702834e-01 0.013 0 0
Glycogen synthesis R-HSA-3322077 9.702834e-01 0.013 0 0
Gene Silencing by RNA R-HSA-211000 9.703190e-01 0.013 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.710444e-01 0.013 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.715754e-01 0.013 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.731244e-01 0.012 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.740457e-01 0.011 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.740457e-01 0.011 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.740724e-01 0.011 0 0
G-protein activation R-HSA-202040 9.741852e-01 0.011 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.741852e-01 0.011 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.741852e-01 0.011 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.741852e-01 0.011 0 0
Abacavir metabolism R-HSA-2161541 9.741852e-01 0.011 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.741852e-01 0.011 0 0
Basigin interactions R-HSA-210991 9.741852e-01 0.011 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.742333e-01 0.011 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.761483e-01 0.010 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.761483e-01 0.010 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.761483e-01 0.010 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.761483e-01 0.010 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.761483e-01 0.010 0 0
Surfactant metabolism R-HSA-5683826 9.766849e-01 0.010 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.768841e-01 0.010 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.774064e-01 0.010 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.775748e-01 0.010 0 0
Ribavirin ADME R-HSA-9755088 9.775748e-01 0.010 0 0
Assembly Of The HIV Virion R-HSA-175474 9.775748e-01 0.010 0 0
Serine metabolism R-HSA-977347 9.775748e-01 0.010 0 0
Glutathione synthesis and recycling R-HSA-174403 9.775748e-01 0.010 0 0
Attachment and Entry R-HSA-9694614 9.775748e-01 0.010 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.776773e-01 0.010 0 0
Late Phase of HIV Life Cycle R-HSA-162599 9.782720e-01 0.010 0 0
eNOS activation R-HSA-203615 9.788417e-01 0.009 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.788417e-01 0.009 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.788417e-01 0.009 0 0
Hyaluronan metabolism R-HSA-2142845 9.788417e-01 0.009 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.788417e-01 0.009 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.788417e-01 0.009 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.790674e-01 0.009 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.790674e-01 0.009 0 0
Nicotinate metabolism R-HSA-196807 9.796638e-01 0.009 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.805196e-01 0.009 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.805196e-01 0.009 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.805196e-01 0.009 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.805196e-01 0.009 0 0
Fructose metabolism R-HSA-5652084 9.805196e-01 0.009 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.805196e-01 0.009 0 0
Cellular hexose transport R-HSA-189200 9.805196e-01 0.009 0 0
Dectin-2 family R-HSA-5621480 9.808735e-01 0.008 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.812165e-01 0.008 0 0
Regulation of Apoptosis R-HSA-169911 9.812393e-01 0.008 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.812393e-01 0.008 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.812393e-01 0.008 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.812393e-01 0.008 0 0
Innate Immune System R-HSA-168249 9.822054e-01 0.008 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.827015e-01 0.008 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.830777e-01 0.007 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.830777e-01 0.007 0 0
Formation of the ureteric bud R-HSA-9830674 9.830777e-01 0.007 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.830777e-01 0.007 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.830777e-01 0.007 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.833722e-01 0.007 0 0
Glycosphingolipid transport R-HSA-9845576 9.833722e-01 0.007 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.833722e-01 0.007 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.846746e-01 0.007 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.848185e-01 0.007 0 0
Degradation of DVL R-HSA-4641258 9.852686e-01 0.006 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.852686e-01 0.006 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.852686e-01 0.006 0 0
Collagen chain trimerization R-HSA-8948216 9.852686e-01 0.006 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.853001e-01 0.006 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.853001e-01 0.006 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.853001e-01 0.006 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.858726e-01 0.006 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.864701e-01 0.006 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.869538e-01 0.006 0 0
Elastic fibre formation R-HSA-1566948 9.869538e-01 0.006 0 0
Interferon gamma signaling R-HSA-877300 9.872038e-01 0.006 0 0
Hyaluronan degradation R-HSA-2160916 9.872308e-01 0.006 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.872308e-01 0.006 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.872308e-01 0.006 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.872308e-01 0.006 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.872308e-01 0.006 0 0
Laminin interactions R-HSA-3000157 9.872308e-01 0.006 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.872428e-01 0.006 0 0
ABC-family proteins mediated transport R-HSA-382556 9.875286e-01 0.005 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.878834e-01 0.005 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.884506e-01 0.005 0 0
Signaling by PDGF R-HSA-186797 9.884859e-01 0.005 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.884859e-01 0.005 0 0
tRNA processing in the nucleus R-HSA-6784531 9.884859e-01 0.005 0 0
HCMV Early Events R-HSA-9609690 9.886519e-01 0.005 0 0
Urea cycle R-HSA-70635 9.889079e-01 0.005 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.889079e-01 0.005 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.891542e-01 0.005 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.892514e-01 0.005 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.895658e-01 0.005 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.897794e-01 0.004 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.897794e-01 0.004 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.902961e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.903649e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.903649e-01 0.004 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.903649e-01 0.004 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.903649e-01 0.004 0 0
Collagen formation R-HSA-1474290 9.904447e-01 0.004 0 0
Phospholipid metabolism R-HSA-1483257 9.908323e-01 0.004 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.909585e-01 0.004 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.909585e-01 0.004 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.909585e-01 0.004 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.912138e-01 0.004 0 0
Nucleotide biosynthesis R-HSA-8956320 9.913215e-01 0.004 0 0
Insulin receptor recycling R-HSA-77387 9.916306e-01 0.004 0 0
Pyrimidine salvage R-HSA-73614 9.916306e-01 0.004 0 0
Pyroptosis R-HSA-5620971 9.916306e-01 0.004 0 0
RSV-host interactions R-HSA-9833110 9.918318e-01 0.004 0 0
Pyruvate metabolism R-HSA-70268 9.923572e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.927300e-01 0.003 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.927300e-01 0.003 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.928378e-01 0.003 0 0
Leishmania phagocytosis R-HSA-9664417 9.928378e-01 0.003 0 0
Parasite infection R-HSA-9664407 9.928378e-01 0.003 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.929313e-01 0.003 0 0
ABC transporter disorders R-HSA-5619084 9.929503e-01 0.003 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.931523e-01 0.003 0 0
Defensins R-HSA-1461973 9.937529e-01 0.003 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.938078e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.938365e-01 0.003 0 0
Synthesis of PA R-HSA-1483166 9.944712e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.944807e-01 0.002 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.945148e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.945148e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.945901e-01 0.002 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.951251e-01 0.002 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.951251e-01 0.002 0 0
Somitogenesis R-HSA-9824272 9.951251e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.951251e-01 0.002 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.952355e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.955168e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.955429e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.955429e-01 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.955975e-01 0.002 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.957836e-01 0.002 0 0
Recycling of bile acids and salts R-HSA-159418 9.958615e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.960735e-01 0.002 0 0
Synthesis of PC R-HSA-1483191 9.962002e-01 0.002 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.964993e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.964993e-01 0.002 0 0
G alpha (i) signalling events R-HSA-418594 9.965805e-01 0.001 0 0
Signal amplification R-HSA-392518 9.968777e-01 0.001 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.968777e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.970414e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.970476e-01 0.001 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.972881e-01 0.001 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.972881e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.972881e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.978164e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.978953e-01 0.001 0 0
Degradation of AXIN R-HSA-4641257 9.979541e-01 0.001 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.979541e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.979541e-01 0.001 0 0
Neddylation R-HSA-8951664 9.980055e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.982230e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.982542e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.982542e-01 0.001 0 0
Signaling by MET R-HSA-6806834 9.983097e-01 0.001 0 0
Viral Infection Pathways R-HSA-9824446 9.983474e-01 0.001 0 0
Glucuronidation R-HSA-156588 9.984241e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.984470e-01 0.001 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.984566e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.984566e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.984566e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.986116e-01 0.001 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.986595e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.986595e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.989087e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.989087e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.989087e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.989087e-01 0.000 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.989888e-01 0.000 0 0
HIV Transcription Initiation R-HSA-167161 9.989888e-01 0.000 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.989888e-01 0.000 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.989888e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.989888e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.989978e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.990304e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.990770e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.991062e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.991217e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.992231e-01 0.000 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.992372e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.992652e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.993208e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.993208e-01 0.000 0 0
Proteasome assembly R-HSA-9907900 9.993375e-01 0.000 0 0
Methylation R-HSA-156581 9.993375e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.993534e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.994124e-01 0.000 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.994246e-01 0.000 0 0
HCMV Infection R-HSA-9609646 9.995148e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.995227e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.995254e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.995254e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.995660e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.995664e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.995790e-01 0.000 0 0
Translation R-HSA-72766 9.996319e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.996508e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.996690e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.996727e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.997050e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.997157e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.997157e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.997168e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.997168e-01 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.997400e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.997531e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.997531e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.997697e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.998400e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998414e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998433e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.998624e-01 0.000 0 0
Digestion R-HSA-8935690 9.998781e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.998791e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999118e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999198e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999272e-01 0.000 0 0
tRNA processing R-HSA-72306 9.999273e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999277e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.999307e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.999398e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999450e-01 0.000 1 0
Peptide ligand-binding receptors R-HSA-375276 9.999539e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999546e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999546e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999606e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999606e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999634e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999658e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999694e-01 0.000 0 0
HCMV Late Events R-HSA-9610379 9.999712e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999770e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999831e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999870e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999882e-01 0.000 0 0
Disease R-HSA-1643685 9.999901e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999907e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999927e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999946e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999947e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999948e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999973e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999984e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999987e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999988e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999990e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999992e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999995e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999995e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999997e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999997e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999998e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 6.661338e-16 15.176 0 0
Nervous system development R-HSA-9675108 9.992007e-16 15.000 0 0
Cell Cycle Checkpoints R-HSA-69620 1.776357e-15 14.750 0 0
HSF1-dependent transactivation R-HSA-3371571 2.098322e-14 13.678 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.205480e-12 11.919 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.441403e-12 11.841 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.441403e-12 11.841 0 0
Signaling by ROBO receptors R-HSA-376176 1.686651e-12 11.773 0 0
Metabolism of RNA R-HSA-8953854 1.634248e-12 11.787 0 0
Attenuation phase R-HSA-3371568 1.857403e-12 11.731 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.314549e-12 11.365 0 0
Apoptosis R-HSA-109581 5.118128e-12 11.291 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.786460e-12 11.168 0 0
Mitotic Anaphase R-HSA-68882 8.246293e-12 11.084 0 0
Apoptotic execution phase R-HSA-75153 8.773204e-12 11.057 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 9.856782e-12 11.006 0 0
Cellular Senescence R-HSA-2559583 9.915180e-12 11.004 0 0
Cell-Cell communication R-HSA-1500931 1.204126e-11 10.919 0 0
Separation of Sister Chromatids R-HSA-2467813 2.285327e-11 10.641 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.882072e-11 10.540 0 0
Translation initiation complex formation R-HSA-72649 4.662681e-11 10.331 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.593914e-11 10.338 0 0
HSF1 activation R-HSA-3371511 4.599687e-11 10.337 0 0
Interleukin-12 signaling R-HSA-9020591 6.557488e-11 10.183 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.813839e-11 10.008 0 0
Interleukin-12 family signaling R-HSA-447115 1.598699e-10 9.796 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.917950e-10 9.717 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.131052e-10 9.671 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.317335e-10 9.635 0 0
Mitotic Prometaphase R-HSA-68877 2.997850e-10 9.523 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.205659e-10 9.207 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.032981e-10 9.153 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.779922e-10 9.010 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.173350e-09 8.931 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.173350e-09 8.931 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.133577e-09 8.946 0 0
Cell junction organization R-HSA-446728 1.446126e-09 8.840 0 0
Peptide chain elongation R-HSA-156902 2.598768e-09 8.585 0 0
Programmed Cell Death R-HSA-5357801 2.568227e-09 8.590 0 0
Influenza Infection R-HSA-168255 3.295605e-09 8.482 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.067853e-09 8.295 0 0
G2/M Checkpoints R-HSA-69481 7.199964e-09 8.143 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 8.104044e-09 8.091 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.369581e-09 8.077 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.530692e-09 8.069 0 0
Ribosome-associated quality control R-HSA-9948299 1.109687e-08 7.955 0 0
Signal Transduction R-HSA-162582 1.113723e-08 7.953 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.801406e-08 7.744 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.807704e-08 7.743 0 0
Eukaryotic Translation Termination R-HSA-72764 2.269576e-08 7.644 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.450679e-08 7.462 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.746496e-08 7.426 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.894650e-08 7.410 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.894650e-08 7.410 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.095043e-08 7.388 0 0
Adherens junctions interactions R-HSA-418990 4.200433e-08 7.377 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.423394e-08 7.354 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.465004e-08 7.350 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.268212e-08 7.278 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.639351e-08 7.249 0 0
Cell-cell junction organization R-HSA-421270 5.869700e-08 7.231 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.158915e-08 7.210 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.500040e-08 7.187 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.776163e-08 7.169 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.938418e-08 7.159 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.181410e-08 7.144 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.777045e-08 7.109 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.296936e-08 7.081 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.718973e-08 7.060 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.196440e-08 7.036 0 0
Recycling pathway of L1 R-HSA-437239 1.069734e-07 6.971 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.072602e-07 6.970 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.381483e-07 6.860 0 0
DNA Double Strand Break Response R-HSA-5693606 1.697899e-07 6.770 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.759153e-07 6.755 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.819378e-07 6.740 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.991778e-07 6.701 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.316921e-07 6.479 0 0
L1CAM interactions R-HSA-373760 3.427483e-07 6.465 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.265615e-07 6.370 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.456842e-07 6.351 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.475741e-07 6.349 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.767215e-07 6.322 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.583572e-07 6.253 0 0
Meiotic synapsis R-HSA-1221632 6.239918e-07 6.205 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.737236e-07 6.172 0 0
Selenocysteine synthesis R-HSA-2408557 6.905345e-07 6.161 0 0
Viral Infection Pathways R-HSA-9824446 7.094533e-07 6.149 0 0
G2/M Transition R-HSA-69275 7.819731e-07 6.107 0 0
Diseases of programmed cell death R-HSA-9645723 8.327306e-07 6.079 0 0
Viral mRNA Translation R-HSA-192823 1.006050e-06 5.997 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.020889e-06 5.991 0 0
HDACs deacetylate histones R-HSA-3214815 1.066759e-06 5.972 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.269237e-06 5.896 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.315645e-06 5.881 0 0
Mitotic Prophase R-HSA-68875 1.791154e-06 5.747 0 0
mRNA Splicing R-HSA-72172 1.846778e-06 5.734 0 0
Post NMDA receptor activation events R-HSA-438064 1.975728e-06 5.704 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.063183e-06 5.685 0 0
ESR-mediated signaling R-HSA-8939211 2.175502e-06 5.662 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.406021e-06 5.619 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.440082e-06 5.613 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.561688e-06 5.591 0 0
Meiosis R-HSA-1500620 3.126800e-06 5.505 0 0
Nucleosome assembly R-HSA-774815 3.228858e-06 5.491 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.228858e-06 5.491 0 0
Homology Directed Repair R-HSA-5693538 3.275262e-06 5.485 0 0
PKR-mediated signaling R-HSA-9833482 3.316303e-06 5.479 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.479928e-06 5.458 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.696100e-06 5.432 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.804319e-06 5.420 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.804319e-06 5.420 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.149817e-06 5.382 0 0
Interferon Signaling R-HSA-913531 4.330486e-06 5.363 0 0
rRNA processing R-HSA-72312 5.221359e-06 5.282 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.527348e-06 5.257 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.288220e-06 5.137 0 0
Aggrephagy R-HSA-9646399 8.054159e-06 5.094 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.054159e-06 5.094 0 0
HATs acetylate histones R-HSA-3214847 9.430923e-06 5.025 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.151196e-05 4.939 0 0
Signaling by ERBB2 R-HSA-1227986 1.167693e-05 4.933 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.226858e-05 4.911 0 0
DNA methylation R-HSA-5334118 1.245392e-05 4.905 0 0
DNA Replication R-HSA-69306 1.252469e-05 4.902 0 0
Striated Muscle Contraction R-HSA-390522 1.494676e-05 4.825 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.800396e-05 4.745 0 0
Selective autophagy R-HSA-9663891 1.816848e-05 4.741 0 0
Regulation of CDH1 Function R-HSA-9764561 1.860974e-05 4.730 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.888865e-05 4.724 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.931777e-05 4.714 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.100285e-05 4.678 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.202870e-05 4.657 0 0
Defective pyroptosis R-HSA-9710421 2.333991e-05 4.632 0 0
Chromatin modifying enzymes R-HSA-3247509 2.540446e-05 4.595 0 0
HCMV Early Events R-HSA-9609690 2.607431e-05 4.584 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.618490e-05 4.582 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.669325e-05 4.574 0 0
Gene expression (Transcription) R-HSA-74160 2.795229e-05 4.554 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.968111e-05 4.528 0 0
Translation R-HSA-72766 3.109212e-05 4.507 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.334555e-05 4.477 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.512467e-05 4.454 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.762940e-05 4.424 0 0
MAPK family signaling cascades R-HSA-5683057 3.603643e-05 4.443 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.857420e-05 4.414 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.867983e-05 4.413 0 0
Muscle contraction R-HSA-397014 3.968909e-05 4.401 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.061032e-05 4.391 0 0
Developmental Biology R-HSA-1266738 4.077608e-05 4.390 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.129829e-05 4.384 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.222299e-05 4.374 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.460864e-05 4.351 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.777245e-05 4.321 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.817330e-05 4.317 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.817330e-05 4.317 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.817330e-05 4.317 0 0
Signaling by RAS mutants R-HSA-6802949 4.817330e-05 4.317 0 0
Meiotic recombination R-HSA-912446 4.737961e-05 4.324 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.979823e-05 4.303 0 0
Cellular response to starvation R-HSA-9711097 5.031063e-05 4.298 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.952364e-05 4.225 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.267395e-05 4.203 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.442598e-05 4.191 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.442598e-05 4.191 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.481514e-05 4.188 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.703738e-05 4.174 0 0
Ephrin signaling R-HSA-3928664 6.703738e-05 4.174 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.999361e-05 4.155 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.896630e-05 4.103 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.876726e-05 4.052 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.289154e-05 4.032 0 0
Gene Silencing by RNA R-HSA-211000 9.317439e-05 4.031 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.703064e-05 4.013 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.743445e-05 4.011 0 0
Chromatin organization R-HSA-4839726 1.048870e-04 3.979 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.784454e-05 4.009 0 0
Packaging Of Telomere Ends R-HSA-171306 1.057703e-04 3.976 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.215244e-04 3.915 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.223086e-04 3.913 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.234025e-04 3.909 0 0
Reproduction R-HSA-1474165 1.283829e-04 3.891 0 0
RNA Polymerase I Transcription R-HSA-73864 1.296133e-04 3.887 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.451640e-04 3.838 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.489950e-04 3.827 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.504280e-04 3.823 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.617286e-04 3.791 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.623297e-04 3.790 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.672245e-04 3.777 0 0
Autophagy R-HSA-9612973 1.714244e-04 3.766 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.748838e-04 3.757 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.793019e-04 3.746 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.998107e-04 3.699 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.959914e-04 3.708 0 0
Protein ubiquitination R-HSA-8852135 2.024776e-04 3.694 0 0
Centrosome maturation R-HSA-380287 2.024776e-04 3.694 0 0
Signaling by Hippo R-HSA-2028269 2.116870e-04 3.674 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.112954e-04 3.675 0 0
Selenoamino acid metabolism R-HSA-2408522 2.010417e-04 3.697 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.128574e-04 3.672 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.145510e-04 3.668 0 0
Host Interactions of HIV factors R-HSA-162909 2.238071e-04 3.650 0 0
Long-term potentiation R-HSA-9620244 2.245441e-04 3.649 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.379924e-04 3.623 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.490019e-04 3.604 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.490019e-04 3.604 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.506611e-04 3.601 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.614433e-04 3.583 0 0
DNA Repair R-HSA-73894 2.758667e-04 3.559 0 0
Signaling by VEGF R-HSA-194138 2.845189e-04 3.546 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.108826e-04 3.507 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.110832e-04 3.507 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.216686e-04 3.493 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.216686e-04 3.493 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.216686e-04 3.493 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.216686e-04 3.493 0 0
Signaling by WNT R-HSA-195721 3.323530e-04 3.478 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.332720e-04 3.477 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.387595e-04 3.470 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.411350e-04 3.467 0 0
mTORC1-mediated signalling R-HSA-166208 3.571300e-04 3.447 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.731615e-04 3.428 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.838039e-04 3.416 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.000834e-04 3.398 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.860371e-04 3.413 0 0
Signaling by Interleukins R-HSA-449147 3.604039e-04 3.443 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.001242e-04 3.398 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.030845e-04 3.395 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.375690e-04 3.359 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.408044e-04 3.356 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.448310e-04 3.352 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.726350e-04 3.325 0 0
Signaling by ALK in cancer R-HSA-9700206 4.726350e-04 3.325 0 0
Signaling by PTK6 R-HSA-8848021 4.734863e-04 3.325 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.734863e-04 3.325 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.759728e-04 3.322 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.763719e-04 3.322 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.931179e-04 3.307 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.997841e-04 3.301 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 4.997841e-04 3.301 0 0
Macroautophagy R-HSA-1632852 5.043973e-04 3.297 0 0
Co-inhibition by PD-1 R-HSA-389948 5.355485e-04 3.271 0 0
HIV Infection R-HSA-162906 5.519408e-04 3.258 0 0
EPH-Ephrin signaling R-HSA-2682334 5.790611e-04 3.237 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.897537e-04 3.229 0 0
Smooth Muscle Contraction R-HSA-445355 5.906899e-04 3.229 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.272274e-04 3.203 0 0
HCMV Infection R-HSA-9609646 6.452335e-04 3.190 0 0
RNA Polymerase II Transcription R-HSA-73857 6.577511e-04 3.182 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.814211e-04 3.107 0 0
Neutrophil degranulation R-HSA-6798695 7.822881e-04 3.107 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.722802e-04 3.172 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.722802e-04 3.172 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.806344e-04 3.108 0 0
Chromosome Maintenance R-HSA-73886 6.979094e-04 3.156 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.043832e-04 3.152 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.975985e-04 3.156 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.095687e-04 3.149 0 0
Glycolysis R-HSA-70171 8.284557e-04 3.082 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.605143e-04 3.065 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.016616e-04 3.045 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.341856e-04 3.030 0 0
Oncogene Induced Senescence R-HSA-2559585 9.969872e-04 3.001 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.009668e-03 2.996 0 0
Ub-specific processing proteases R-HSA-5689880 1.017737e-03 2.992 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.067085e-03 2.972 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.136001e-03 2.945 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.188995e-03 2.925 0 0
Amyloid fiber formation R-HSA-977225 1.190554e-03 2.924 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.222101e-03 2.913 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.222101e-03 2.913 0 0
RET signaling R-HSA-8853659 1.226559e-03 2.911 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.242060e-03 2.906 0 0
Protein folding R-HSA-391251 1.285825e-03 2.891 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.326981e-03 2.877 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.335299e-03 2.874 0 0
MAP2K and MAPK activation R-HSA-5674135 1.373152e-03 2.862 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.395039e-03 2.855 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.428767e-03 2.845 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.480769e-03 2.830 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.498547e-03 2.824 0 0
Cleavage of the damaged purine R-HSA-110331 1.498547e-03 2.824 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.553188e-03 2.809 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.553896e-03 2.809 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.575143e-03 2.803 0 0
Membrane Trafficking R-HSA-199991 1.576354e-03 2.802 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.607119e-03 2.794 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.811180e-03 2.742 0 0
Nucleotide Excision Repair R-HSA-5696398 1.676134e-03 2.776 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.607119e-03 2.794 0 0
Deubiquitination R-HSA-5688426 1.586541e-03 2.800 0 0
Regulation of TP53 Activity R-HSA-5633007 1.822962e-03 2.739 0 0
Generic Transcription Pathway R-HSA-212436 1.731591e-03 2.762 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.899877e-03 2.721 0 0
Kinesins R-HSA-983189 1.856670e-03 2.731 0 0
Depurination R-HSA-73927 1.818749e-03 2.740 0 0
SARS-CoV Infections R-HSA-9679506 1.614997e-03 2.792 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.650288e-03 2.782 0 0
Depyrimidination R-HSA-73928 1.650288e-03 2.782 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.974524e-03 2.705 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.113218e-03 2.675 0 0
S Phase R-HSA-69242 2.122800e-03 2.673 0 0
Nephrin family interactions R-HSA-373753 2.137106e-03 2.670 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.137106e-03 2.670 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.153349e-03 2.667 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.193433e-03 2.659 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.193433e-03 2.659 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.254129e-03 2.647 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.326218e-03 2.633 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.327706e-03 2.633 0 0
Cellular response to chemical stress R-HSA-9711123 2.351823e-03 2.629 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.353958e-03 2.628 0 0
Cilium Assembly R-HSA-5617833 2.367582e-03 2.626 0 0
Dual Incision in GG-NER R-HSA-5696400 2.408025e-03 2.618 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.483092e-03 2.605 0 0
HIV Life Cycle R-HSA-162587 2.558844e-03 2.592 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.605249e-03 2.584 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.747640e-03 2.561 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.764522e-03 2.558 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.764522e-03 2.558 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.866210e-03 2.543 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.916093e-03 2.535 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.493612e-03 2.457 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.507496e-03 2.455 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.525370e-03 2.453 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.525370e-03 2.453 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.529299e-03 2.452 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.575066e-03 2.447 0 0
Hedgehog 'off' state R-HSA-5610787 3.611218e-03 2.442 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.714014e-03 2.430 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.714014e-03 2.430 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.714014e-03 2.430 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.877256e-03 2.411 0 0
Base Excision Repair R-HSA-73884 4.059715e-03 2.392 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.192598e-03 2.378 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.192598e-03 2.378 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.573376e-03 2.340 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.702459e-03 2.328 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.746548e-03 2.324 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.929456e-03 2.307 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 5.412865e-03 2.267 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.679050e-03 2.246 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.679050e-03 2.246 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.154371e-03 2.288 0 0
Late endosomal microautophagy R-HSA-9615710 6.257573e-03 2.204 0 0
Degradation of CDH1 R-HSA-9766229 5.179235e-03 2.286 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.895379e-03 2.229 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.994085e-03 2.222 0 0
DNA Damage Bypass R-HSA-73893 5.179235e-03 2.286 0 0
Translesion Synthesis by POLH R-HSA-110320 5.776211e-03 2.238 0 0
Rap1 signalling R-HSA-392517 5.776211e-03 2.238 0 0
Telomere Maintenance R-HSA-157579 5.265973e-03 2.279 0 0
RMTs methylate histone arginines R-HSA-3214858 5.994085e-03 2.222 0 0
Gap junction trafficking and regulation R-HSA-157858 5.179235e-03 2.286 0 0
Gap junction trafficking R-HSA-190828 5.994085e-03 2.222 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.179235e-03 2.286 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.179235e-03 2.286 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.474821e-03 2.262 0 0
Stabilization of p53 R-HSA-69541 5.882547e-03 2.230 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.265973e-03 2.279 0 0
Regulation of PTEN localization R-HSA-8948747 5.412865e-03 2.267 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.895379e-03 2.229 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.538329e-03 2.257 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.308609e-03 2.200 0 0
Semaphorin interactions R-HSA-373755 6.522059e-03 2.186 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.589189e-03 2.181 0 0
Nuclear import of Rev protein R-HSA-180746 6.691147e-03 2.174 0 0
Glucose metabolism R-HSA-70326 6.827892e-03 2.166 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.847699e-03 2.164 0 0
Neurodegenerative Diseases R-HSA-8863678 6.847699e-03 2.164 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.847699e-03 2.164 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 6.909151e-03 2.161 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.933672e-03 2.159 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.933672e-03 2.159 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.933672e-03 2.159 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.933672e-03 2.159 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.933672e-03 2.159 0 0
DAG and IP3 signaling R-HSA-1489509 6.963231e-03 2.157 0 0
Negative regulation of MET activity R-HSA-6807004 7.289400e-03 2.137 0 0
Phosphorylation of the APC/C R-HSA-176412 7.413079e-03 2.130 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.413079e-03 2.130 0 0
Negative regulation of FLT3 R-HSA-9706369 7.413079e-03 2.130 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.536098e-03 2.123 0 0
Activation of BH3-only proteins R-HSA-114452 7.536098e-03 2.123 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.919786e-03 2.101 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 7.938716e-03 2.100 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.977704e-03 2.098 0 0
Formation of annular gap junctions R-HSA-196025 7.977704e-03 2.098 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.977704e-03 2.098 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.977704e-03 2.098 0 0
Synthesis of DNA R-HSA-69239 7.980659e-03 2.098 0 0
FLT3 Signaling R-HSA-9607240 8.071812e-03 2.093 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.082438e-03 2.092 0 0
Cellular response to hypoxia R-HSA-1234174 8.345728e-03 2.079 0 0
Trafficking of AMPA receptors R-HSA-399719 9.007263e-03 2.045 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 9.007263e-03 2.045 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.007263e-03 2.045 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 9.007263e-03 2.045 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.007263e-03 2.045 0 0
Infectious disease R-HSA-5663205 9.101636e-03 2.041 0 0
Calmodulin induced events R-HSA-111933 9.316863e-03 2.031 0 0
CaM pathway R-HSA-111997 9.316863e-03 2.031 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 9.510383e-03 2.022 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.510383e-03 2.022 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 9.510383e-03 2.022 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.613401e-03 2.017 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.012709e-02 1.995 0 0
Metalloprotease DUBs R-HSA-5689901 1.012709e-02 1.995 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.019851e-02 1.991 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.022764e-02 1.990 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.022764e-02 1.990 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.022764e-02 1.990 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.022764e-02 1.990 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.028906e-02 1.988 0 0
Immune System R-HSA-168256 1.034171e-02 1.985 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.036803e-02 1.984 0 0
Signaling by MET R-HSA-6806834 1.040877e-02 1.983 0 0
TCR signaling R-HSA-202403 1.046061e-02 1.980 0 0
Signaling by NOTCH R-HSA-157118 1.047351e-02 1.980 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.076186e-02 1.968 0 0
Gap junction degradation R-HSA-190873 1.128321e-02 1.948 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.225708e-02 1.912 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.201113e-02 1.920 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.215349e-02 1.915 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.259817e-02 1.900 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.259817e-02 1.900 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.085203e-02 1.964 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.380915e-02 1.860 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.128321e-02 1.948 0 0
Degradation of DVL R-HSA-4641258 1.089669e-02 1.963 0 0
MTOR signalling R-HSA-165159 1.085203e-02 1.964 0 0
UCH proteinases R-HSA-5689603 1.373141e-02 1.862 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.246117e-02 1.904 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.128321e-02 1.948 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.225708e-02 1.912 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.292725e-02 1.888 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.446752e-02 1.840 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.167226e-02 1.933 0 0
Ion homeostasis R-HSA-5578775 1.319604e-02 1.880 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.404371e-02 1.853 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.176698e-02 1.929 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.089669e-02 1.963 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.215349e-02 1.915 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.259817e-02 1.900 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.225708e-02 1.912 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.319604e-02 1.880 0 0
Maturation of protein E R-HSA-9683683 1.246117e-02 1.904 0 0
Maturation of protein E R-HSA-9694493 1.246117e-02 1.904 0 0
G1/S Transition R-HSA-69206 1.448647e-02 1.839 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.470748e-02 1.832 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.475349e-02 1.831 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.541635e-02 1.812 0 0
Josephin domain DUBs R-HSA-5689877 1.541635e-02 1.812 0 0
Pexophagy R-HSA-9664873 1.541635e-02 1.812 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.541635e-02 1.812 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.578062e-02 1.802 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.578062e-02 1.802 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.578062e-02 1.802 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.633962e-02 1.787 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.633962e-02 1.787 0 0
PTEN Regulation R-HSA-6807070 1.635326e-02 1.786 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.644316e-02 1.784 0 0
Dual incision in TC-NER R-HSA-6782135 1.670087e-02 1.777 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.687773e-02 1.773 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.687773e-02 1.773 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.687773e-02 1.773 0 0
Platelet degranulation R-HSA-114608 1.688433e-02 1.773 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.709126e-02 1.767 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.709126e-02 1.767 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.709126e-02 1.767 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.717231e-02 1.765 0 0
Mitophagy R-HSA-5205647 1.717231e-02 1.765 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.717231e-02 1.765 0 0
mRNA 3'-end processing R-HSA-72187 1.767004e-02 1.753 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.837793e-02 1.736 0 0
Sensory processing of sound R-HSA-9659379 1.854062e-02 1.732 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.856855e-02 1.731 0 0
Metabolism of non-coding RNA R-HSA-194441 1.869974e-02 1.728 0 0
snRNP Assembly R-HSA-191859 1.869974e-02 1.728 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.933349e-02 1.714 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.933349e-02 1.714 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.933349e-02 1.714 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.965051e-02 1.707 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.987197e-02 1.702 0 0
Regulation of Apoptosis R-HSA-169911 1.987197e-02 1.702 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.994865e-02 1.700 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.994865e-02 1.700 0 0
Translesion synthesis by REV1 R-HSA-110312 1.994865e-02 1.700 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.004619e-02 1.698 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.004619e-02 1.698 0 0
Interleukin-37 signaling R-HSA-9008059 2.004619e-02 1.698 0 0
PECAM1 interactions R-HSA-210990 2.045372e-02 1.689 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.045372e-02 1.689 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.060198e-02 1.686 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.060198e-02 1.686 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.091128e-02 1.680 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.091128e-02 1.680 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.091128e-02 1.680 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.091128e-02 1.680 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.091128e-02 1.680 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.091128e-02 1.680 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.091128e-02 1.680 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.163450e-02 1.665 0 0
Signaling by ERBB4 R-HSA-1236394 2.209446e-02 1.656 0 0
Formation of definitive endoderm R-HSA-9823730 2.231681e-02 1.651 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.286937e-02 1.641 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.431733e-02 1.614 0 0
Translesion synthesis by POLI R-HSA-5656121 2.480753e-02 1.605 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.480753e-02 1.605 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.480753e-02 1.605 0 0
Ca-dependent events R-HSA-111996 2.502289e-02 1.602 0 0
Signaling by Hedgehog R-HSA-5358351 2.537173e-02 1.596 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.568313e-02 1.590 0 0
Activation of RAC1 R-HSA-428540 2.645984e-02 1.577 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.645984e-02 1.577 0 0
Integration of provirus R-HSA-162592 2.645984e-02 1.577 0 0
NF-kB is activated and signals survival R-HSA-209560 2.645984e-02 1.577 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.663103e-02 1.575 0 0
Basigin interactions R-HSA-210991 2.680361e-02 1.572 0 0
Signaling by EGFR R-HSA-177929 2.776635e-02 1.556 0 0
Signaling by FGFR4 R-HSA-5654743 2.828347e-02 1.548 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.902287e-02 1.537 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.941462e-02 1.531 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.941462e-02 1.531 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.982171e-02 1.525 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.380204e-02 1.359 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.315025e-02 1.365 0 0
WNT mediated activation of DVL R-HSA-201688 4.502809e-02 1.347 0 0
Translesion synthesis by POLK R-HSA-5655862 3.039777e-02 1.517 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.675337e-02 1.435 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.390135e-02 1.358 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.186759e-02 1.497 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.186759e-02 1.497 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.190152e-02 1.496 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.557658e-02 1.449 0 0
RAF activation R-HSA-5673000 4.047572e-02 1.393 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.047572e-02 1.393 0 0
Orc1 removal from chromatin R-HSA-68949 3.695824e-02 1.432 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.286260e-02 1.368 0 0
Generation of second messenger molecules R-HSA-202433 3.814961e-02 1.419 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.492301e-02 1.457 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.502809e-02 1.347 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.183836e-02 1.497 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.095951e-02 1.388 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.492301e-02 1.457 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.186759e-02 1.497 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.110041e-02 1.507 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.348598e-02 1.475 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.558681e-02 1.449 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.084274e-02 1.511 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.047572e-02 1.393 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.324119e-02 1.478 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.380204e-02 1.359 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.186759e-02 1.497 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.110041e-02 1.507 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.286260e-02 1.368 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.174371e-02 1.379 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.175554e-02 1.498 0 0
Signaling by FGFR3 R-HSA-5654741 3.569953e-02 1.447 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.248110e-02 1.372 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.095951e-02 1.388 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.753437e-02 1.426 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.380679e-02 1.471 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.170004e-02 1.499 0 0
Gap junction assembly R-HSA-190861 4.047572e-02 1.393 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.154345e-02 1.381 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.333475e-02 1.477 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.456924e-02 1.461 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.502809e-02 1.347 0 0
IRAK1 recruits IKK complex R-HSA-937039 3.348598e-02 1.475 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 3.348598e-02 1.475 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.186759e-02 1.497 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.814961e-02 1.419 0 0
HCMV Late Events R-HSA-9610379 3.494719e-02 1.457 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.753437e-02 1.426 0 0
Interleukin-6 signaling R-HSA-1059683 4.156960e-02 1.381 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.348598e-02 1.475 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.817890e-02 1.418 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.456924e-02 1.461 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.557658e-02 1.449 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.047572e-02 1.393 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.987813e-02 1.399 0 0
Signaling by NOTCH4 R-HSA-9013694 4.164733e-02 1.380 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.377770e-02 1.359 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.186759e-02 1.497 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.390135e-02 1.358 0 0
Assembly Of The HIV Virion R-HSA-175474 3.186759e-02 1.497 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.286260e-02 1.368 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.456924e-02 1.461 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.562807e-02 1.341 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.581166e-02 1.339 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.795691e-02 1.319 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.854869e-02 1.314 0 0
tRNA processing in the nucleus R-HSA-6784531 4.998379e-02 1.301 0 0
Signaling by NTRKs R-HSA-166520 5.007713e-02 1.300 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.073412e-02 1.295 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.073412e-02 1.295 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.073412e-02 1.295 0 0
FLT3 signaling in disease R-HSA-9682385 5.159639e-02 1.287 0 0
Regulation of signaling by CBL R-HSA-912631 5.186144e-02 1.285 0 0
Adaptive Immune System R-HSA-1280218 5.293254e-02 1.276 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.413169e-02 1.267 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.413169e-02 1.267 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.441677e-02 1.264 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.515261e-02 1.258 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.704450e-02 1.244 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.706143e-02 1.244 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.706143e-02 1.244 0 0
2-LTR circle formation R-HSA-164843 5.706143e-02 1.244 0 0
Signaling by Leptin R-HSA-2586552 5.706143e-02 1.244 0 0
PCP/CE pathway R-HSA-4086400 5.776197e-02 1.238 0 0
Degradation of AXIN R-HSA-4641257 5.783992e-02 1.238 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.783992e-02 1.238 0 0
Hedgehog 'on' state R-HSA-5632684 5.876771e-02 1.231 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.876771e-02 1.231 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.932721e-02 1.227 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 5.932721e-02 1.227 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.953316e-02 1.225 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.953316e-02 1.225 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.953316e-02 1.225 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.064597e-02 1.217 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.098916e-02 1.215 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.098916e-02 1.215 0 0
Protein methylation R-HSA-8876725 6.098916e-02 1.215 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.098916e-02 1.215 0 0
p75NTR signals via NF-kB R-HSA-193639 6.098916e-02 1.215 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.230258e-02 1.205 0 0
Netrin-1 signaling R-HSA-373752 6.561836e-02 1.183 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.585834e-02 1.181 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.588838e-02 1.181 0 0
Signaling by FGFR2 R-HSA-5654738 6.723318e-02 1.172 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.723318e-02 1.172 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.749104e-02 1.171 0 0
Developmental Cell Lineages R-HSA-9734767 6.910579e-02 1.160 0 0
Integrin signaling R-HSA-354192 7.000525e-02 1.155 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.000525e-02 1.155 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.000525e-02 1.155 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.025985e-02 1.153 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.025985e-02 1.153 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.212196e-02 1.142 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.232099e-02 1.141 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.232099e-02 1.141 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.232099e-02 1.141 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.232099e-02 1.141 0 0
Prolonged ERK activation events R-HSA-169893 7.233102e-02 1.141 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 7.233102e-02 1.141 0 0
Regulation of TP53 Expression R-HSA-6804754 7.254461e-02 1.139 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 7.254461e-02 1.139 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 7.254461e-02 1.139 0 0
Diseases of Cellular Senescence R-HSA-9630747 7.254461e-02 1.139 0 0
Diseases of cellular response to stress R-HSA-9675132 7.254461e-02 1.139 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 7.254461e-02 1.139 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 7.254461e-02 1.139 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.254461e-02 1.139 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.551465e-02 1.122 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.551465e-02 1.122 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.756402e-02 1.110 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.756402e-02 1.110 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.756402e-02 1.110 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.756402e-02 1.110 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.756402e-02 1.110 0 0
Vesicle-mediated transport R-HSA-5653656 7.814628e-02 1.107 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.826421e-02 1.106 0 0
CREB phosphorylation R-HSA-199920 7.838623e-02 1.106 0 0
Nef and signal transduction R-HSA-164944 7.838623e-02 1.106 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.943870e-02 1.100 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.070073e-02 1.093 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.474351e-02 1.072 0 0
Disorders of Developmental Biology R-HSA-9675151 8.474351e-02 1.072 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 8.474351e-02 1.072 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.474351e-02 1.072 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.474351e-02 1.072 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.474351e-02 1.072 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.474351e-02 1.072 0 0
MHC class II antigen presentation R-HSA-2132295 8.491154e-02 1.071 0 0
HIV elongation arrest and recovery R-HSA-167287 8.509850e-02 1.070 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.509850e-02 1.070 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.509850e-02 1.070 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.707995e-02 1.060 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.752773e-02 1.058 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.752773e-02 1.058 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.183018e-02 1.037 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.195920e-02 1.036 0 0
Interleukin-1 family signaling R-HSA-446652 9.271047e-02 1.033 0 0
Signaling by TGFB family members R-HSA-9006936 9.309313e-02 1.031 0 0
G alpha (z) signalling events R-HSA-418597 9.312344e-02 1.031 0 0
Platelet calcium homeostasis R-HSA-418360 9.534330e-02 1.021 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.614036e-02 1.017 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.644985e-02 1.016 0 0
Signalling to ERKs R-HSA-187687 9.644985e-02 1.016 0 0
IRE1alpha activates chaperones R-HSA-381070 9.779639e-02 1.010 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 9.819887e-02 1.008 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 9.819887e-02 1.008 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.819887e-02 1.008 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.819887e-02 1.008 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 9.948614e-02 1.002 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 9.948614e-02 1.002 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 9.948614e-02 1.002 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 9.948614e-02 1.002 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 9.948614e-02 1.002 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.972964e-02 1.001 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.972964e-02 1.001 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.972964e-02 1.001 0 0
TNF signaling R-HSA-75893 1.008642e-01 0.996 0 0
Signaling by FGFR1 R-HSA-5654736 1.008642e-01 0.996 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.022204e-01 0.990 0 0
Disorders of Nervous System Development R-HSA-9697154 1.022204e-01 0.990 0 0
Pervasive developmental disorders R-HSA-9005895 1.022204e-01 0.990 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.022204e-01 0.990 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.022204e-01 0.990 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.022204e-01 0.990 0 0
Regulation of IFNG signaling R-HSA-877312 1.022204e-01 0.990 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.022204e-01 0.990 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.022204e-01 0.990 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.041506e-01 0.982 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.041506e-01 0.982 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.041506e-01 0.982 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.041506e-01 0.982 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.041506e-01 0.982 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.052264e-01 0.978 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.056731e-01 0.976 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.056731e-01 0.976 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.056731e-01 0.976 0 0
MET activates PTPN11 R-HSA-8865999 1.056731e-01 0.976 0 0
Activation of the pre-replicative complex R-HSA-68962 1.062395e-01 0.974 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.065236e-01 0.973 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.082456e-01 0.966 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.974593e-01 0.705 0 0
MGMT-mediated DNA damage reversal R-HSA-5657655 1.974593e-01 0.705 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.974593e-01 0.705 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.974593e-01 0.705 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 1.974593e-01 0.705 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.974593e-01 0.705 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.974593e-01 0.705 0 0
Hereditary fructose intolerance R-HSA-5657560 1.974593e-01 0.705 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.974593e-01 0.705 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.974593e-01 0.705 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.974593e-01 0.705 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.974593e-01 0.705 0 0
Regulation of gap junction activity R-HSA-191650 1.419632e-01 0.848 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.419632e-01 0.848 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.419632e-01 0.848 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.419632e-01 0.848 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.803979e-01 0.744 0 0
Co-inhibition by BTLA R-HSA-9927353 1.803979e-01 0.744 0 0
IRS activation R-HSA-74713 1.803979e-01 0.744 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.803979e-01 0.744 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.803979e-01 0.744 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.225805e-01 0.912 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.225805e-01 0.912 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.225805e-01 0.912 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.474016e-01 0.831 0 0
ARMS-mediated activation R-HSA-170984 1.474016e-01 0.831 0 0
Lipophagy R-HSA-9613354 1.474016e-01 0.831 0 0
Calcineurin activates NFAT R-HSA-2025928 1.474016e-01 0.831 0 0
Formation of axial mesoderm R-HSA-9796292 1.200544e-01 0.921 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.200544e-01 0.921 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.736764e-01 0.760 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.391179e-01 0.857 0 0
GAB1 signalosome R-HSA-180292 1.126589e-01 0.948 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.011350e-01 0.697 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.592967e-01 0.798 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.443954e-01 0.840 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 1.804691e-01 0.744 0 0
EGFR downregulation R-HSA-182971 1.177734e-01 0.929 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.447574e-01 0.839 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.597458e-01 0.797 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.597458e-01 0.797 0 0
Notch-HLH transcription pathway R-HSA-350054 1.981167e-01 0.703 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.915914e-01 0.718 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.698804e-01 0.770 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.308523e-01 0.883 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.408361e-01 0.851 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.481438e-01 0.829 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.594944e-01 0.797 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.982792e-01 0.703 0 0
Adrenoceptors R-HSA-390696 1.225805e-01 0.912 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.574994e-01 0.803 0 0
Protein localization R-HSA-9609507 1.928554e-01 0.715 0 0
G alpha (12/13) signalling events R-HSA-416482 1.594944e-01 0.797 0 0
Myogenesis R-HSA-525793 1.447574e-01 0.839 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.597458e-01 0.797 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.426801e-01 0.846 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.981167e-01 0.703 0 0
Frs2-mediated activation R-HSA-170968 1.200544e-01 0.921 0 0
DCC mediated attractive signaling R-HSA-418885 1.592967e-01 0.798 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.208071e-01 0.918 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.794854e-01 0.746 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.803979e-01 0.744 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 1.803979e-01 0.744 0 0
Regulation of CDH11 function R-HSA-9762292 1.736764e-01 0.760 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.804691e-01 0.744 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.597458e-01 0.797 0 0
GPER1 signaling R-HSA-9634597 1.692430e-01 0.771 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.126589e-01 0.948 0 0
Budding and maturation of HIV virion R-HSA-162588 1.177734e-01 0.929 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.331078e-01 0.876 0 0
G0 and Early G1 R-HSA-1538133 1.299273e-01 0.886 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.331078e-01 0.876 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.543393e-01 0.812 0 0
FOXO-mediated transcription R-HSA-9614085 1.620079e-01 0.790 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.177815e-01 0.662 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.447574e-01 0.839 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.574994e-01 0.803 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.447574e-01 0.839 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.974593e-01 0.705 0 0
NADE modulates death signalling R-HSA-205025 1.419632e-01 0.848 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.803979e-01 0.744 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.803979e-01 0.744 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.200544e-01 0.921 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.352613e-01 0.869 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.900999e-01 0.721 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.574994e-01 0.803 0 0
G1 Phase R-HSA-69236 2.180437e-01 0.661 0 0
Cyclin D associated events in G1 R-HSA-69231 2.180437e-01 0.661 0 0
Interleukin-1 signaling R-HSA-9020702 1.787484e-01 0.748 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.915914e-01 0.718 0 0
Signal transduction by L1 R-HSA-445144 1.443954e-01 0.840 0 0
ER-Phagosome pathway R-HSA-1236974 1.296264e-01 0.887 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.607876e-01 0.794 0 0
MAP kinase activation R-HSA-450294 1.450192e-01 0.839 0 0
Signaling by SCF-KIT R-HSA-1433557 1.147805e-01 0.940 0 0
DARPP-32 events R-HSA-180024 1.915914e-01 0.718 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.212622e-01 0.916 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.900999e-01 0.721 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.736764e-01 0.760 0 0
Signaling by NOTCH1 R-HSA-1980143 1.416796e-01 0.849 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.304490e-01 0.885 0 0
Death Receptor Signaling R-HSA-73887 2.001413e-01 0.699 0 0
Inhibition of PKR R-HSA-169131 1.974593e-01 0.705 0 0
MTF1 activates gene expression R-HSA-5660489 1.419632e-01 0.848 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.803979e-01 0.744 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 1.803979e-01 0.744 0 0
Protein hydroxylation R-HSA-9629569 1.443954e-01 0.840 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.173734e-01 0.663 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.450192e-01 0.839 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.637932e-01 0.786 0 0
Opioid Signalling R-HSA-111885 1.394349e-01 0.856 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.161003e-01 0.935 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.756562e-01 0.755 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.025094e-01 0.694 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.067368e-01 0.685 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.552578e-01 0.809 0 0
G-protein mediated events R-HSA-112040 1.301827e-01 0.885 0 0
Transmission across Chemical Synapses R-HSA-112315 1.700135e-01 0.770 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.447574e-01 0.839 0 0
PLC beta mediated events R-HSA-112043 1.450192e-01 0.839 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.225805e-01 0.912 0 0
Hemostasis R-HSA-109582 1.171109e-01 0.931 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.620079e-01 0.790 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.450192e-01 0.839 0 0
Signaling by NOTCH3 R-HSA-9012852 1.619455e-01 0.791 0 0
Ethanol oxidation R-HSA-71384 1.981167e-01 0.703 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.393154e-01 0.856 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.794854e-01 0.746 0 0
Interleukin-7 signaling R-HSA-1266695 1.304490e-01 0.885 0 0
Glycogen metabolism R-HSA-8982491 1.513148e-01 0.820 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.560070e-01 0.807 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.108372e-01 0.676 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.615543e-01 0.792 0 0
Signal regulatory protein family interactions R-HSA-391160 1.391179e-01 0.857 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.199755e-01 0.658 0 0
Triglyceride catabolism R-HSA-163560 1.991424e-01 0.701 0 0
Gluconeogenesis R-HSA-70263 1.692430e-01 0.771 0 0
G1/S-Specific Transcription R-HSA-69205 1.991424e-01 0.701 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.543002e-01 0.812 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 1.891678e-01 0.723 0 0
NrCAM interactions R-HSA-447038 1.803979e-01 0.744 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.915914e-01 0.718 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.352613e-01 0.869 0 0
Growth hormone receptor signaling R-HSA-982772 2.173734e-01 0.663 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.592967e-01 0.798 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.038802e-01 0.691 0 0
Regulation of BACH1 activity R-HSA-9708530 1.804691e-01 0.744 0 0
Pentose phosphate pathway disease R-HSA-6791465 2.201374e-01 0.657 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.201374e-01 0.657 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.201374e-01 0.657 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.201374e-01 0.657 0 0
Phosphorylation of Emi1 R-HSA-176417 2.201374e-01 0.657 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.201374e-01 0.657 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 2.201374e-01 0.657 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.201374e-01 0.657 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.201374e-01 0.657 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.201374e-01 0.657 0 0
Regulated Necrosis R-HSA-5218859 2.207944e-01 0.656 0 0
Specification of primordial germ cells R-HSA-9827857 2.252896e-01 0.647 0 0
Glycogen storage diseases R-HSA-3229121 2.252896e-01 0.647 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.256129e-01 0.647 0 0
Downstream signal transduction R-HSA-186763 2.256129e-01 0.647 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.262513e-01 0.645 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.262513e-01 0.645 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.262513e-01 0.645 0 0
Signaling by FGFR R-HSA-190236 2.262513e-01 0.645 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.295167e-01 0.639 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.295167e-01 0.639 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 2.295167e-01 0.639 0 0
MET promotes cell motility R-HSA-8875878 2.301961e-01 0.638 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.301961e-01 0.638 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.325626e-01 0.633 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 2.325626e-01 0.633 0 0
Deadenylation of mRNA R-HSA-429947 2.371784e-01 0.625 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.371784e-01 0.625 0 0
Interleukin-6 family signaling R-HSA-6783589 2.371784e-01 0.625 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.371784e-01 0.625 0 0
Interleukin-17 signaling R-HSA-448424 2.449648e-01 0.611 0 0
ABC-family proteins mediated transport R-HSA-382556 2.465074e-01 0.608 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.474079e-01 0.607 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.486819e-01 0.604 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.486819e-01 0.604 0 0
PKA activation R-HSA-163615 2.486819e-01 0.604 0 0
Apoptotic factor-mediated response R-HSA-111471 2.486819e-01 0.604 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.486819e-01 0.604 0 0
PKA activation in glucagon signalling R-HSA-164378 2.486819e-01 0.604 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.486819e-01 0.604 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.535135e-01 0.596 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.574539e-01 0.589 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.574539e-01 0.589 0 0
HDMs demethylate histones R-HSA-3214842 2.574539e-01 0.589 0 0
Tight junction interactions R-HSA-420029 2.574539e-01 0.589 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.574539e-01 0.589 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.585739e-01 0.587 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.585739e-01 0.587 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.585739e-01 0.587 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.585739e-01 0.587 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.585739e-01 0.587 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.585739e-01 0.587 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.585739e-01 0.587 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.585739e-01 0.587 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.585739e-01 0.587 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.604935e-01 0.584 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.604935e-01 0.584 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.604935e-01 0.584 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 2.604935e-01 0.584 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 2.604935e-01 0.584 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.604935e-01 0.584 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.604935e-01 0.584 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.604935e-01 0.584 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.614008e-01 0.583 0 0
G-protein beta:gamma signalling R-HSA-397795 2.614008e-01 0.583 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.614008e-01 0.583 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.614008e-01 0.583 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.614008e-01 0.583 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.614008e-01 0.583 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.625497e-01 0.581 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.627443e-01 0.580 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.636250e-01 0.579 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.725605e-01 0.565 0 0
Other interleukin signaling R-HSA-449836 2.725605e-01 0.565 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.725605e-01 0.565 0 0
Ion transport by P-type ATPases R-HSA-936837 2.730214e-01 0.564 0 0
Disease R-HSA-1643685 2.733181e-01 0.563 0 0
Intraflagellar transport R-HSA-5620924 2.779577e-01 0.556 0 0
Co-stimulation by CD28 R-HSA-389356 2.779577e-01 0.556 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 2.781218e-01 0.556 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.781218e-01 0.556 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.798240e-01 0.553 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.810542e-01 0.551 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.810542e-01 0.551 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.810542e-01 0.551 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.810542e-01 0.551 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.810542e-01 0.551 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.810542e-01 0.551 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 2.810542e-01 0.551 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.810542e-01 0.551 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.810542e-01 0.551 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.810542e-01 0.551 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.810542e-01 0.551 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.810542e-01 0.551 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.810542e-01 0.551 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.810542e-01 0.551 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.810542e-01 0.551 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.810542e-01 0.551 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.810542e-01 0.551 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.810542e-01 0.551 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.810542e-01 0.551 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.880751e-01 0.540 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.880751e-01 0.540 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 2.880751e-01 0.540 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.880751e-01 0.540 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.968033e-01 0.528 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.968033e-01 0.528 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.968033e-01 0.528 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.968033e-01 0.528 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.968033e-01 0.528 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.968033e-01 0.528 0 0
Glycogen synthesis R-HSA-3322077 2.968033e-01 0.528 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.985279e-01 0.525 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.985279e-01 0.525 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.991048e-01 0.524 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.991048e-01 0.524 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 2.991048e-01 0.524 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.009070e-01 0.522 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.009070e-01 0.522 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.009070e-01 0.522 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.009070e-01 0.522 0 0
Recycling of eIF2:GDP R-HSA-72731 3.009070e-01 0.522 0 0
SOS-mediated signalling R-HSA-112412 3.009070e-01 0.522 0 0
Disinhibition of SNARE formation R-HSA-114516 3.009070e-01 0.522 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.009070e-01 0.522 0 0
Netrin mediated repulsion signals R-HSA-418886 3.009070e-01 0.522 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.009070e-01 0.522 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.054257e-01 0.515 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.075749e-01 0.512 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 3.136804e-01 0.504 0 0
Regulation of insulin secretion R-HSA-422356 3.168100e-01 0.499 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.178074e-01 0.498 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.178074e-01 0.498 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.178074e-01 0.498 0 0
Regulation of KIT signaling R-HSA-1433559 3.178074e-01 0.498 0 0
Malate-aspartate shuttle R-HSA-9856872 3.178074e-01 0.498 0 0
HDL assembly R-HSA-8963896 3.178074e-01 0.498 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.203268e-01 0.494 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.203268e-01 0.494 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 3.212928e-01 0.493 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.212928e-01 0.493 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.212928e-01 0.493 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.212928e-01 0.493 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.212928e-01 0.493 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.212928e-01 0.493 0 0
Transcription of the HIV genome R-HSA-167172 3.285308e-01 0.483 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.291796e-01 0.483 0 0
TBC/RABGAPs R-HSA-8854214 3.310625e-01 0.480 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 3.350906e-01 0.475 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.365646e-01 0.473 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.379477e-01 0.471 0 0
Type I hemidesmosome assembly R-HSA-446107 3.409285e-01 0.467 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.409285e-01 0.467 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 3.409285e-01 0.467 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.409285e-01 0.467 0 0
Interleukin-23 signaling R-HSA-9020933 3.409285e-01 0.467 0 0
Interleukin-9 signaling R-HSA-8985947 3.409285e-01 0.467 0 0
Neurexins and neuroligins R-HSA-6794361 3.416264e-01 0.466 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.416264e-01 0.466 0 0
Signaling by Erythropoietin R-HSA-9006335 3.417143e-01 0.466 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.417143e-01 0.466 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.417143e-01 0.466 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.448663e-01 0.462 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.459175e-01 0.461 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.475769e-01 0.459 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.475769e-01 0.459 0 0
p38MAPK events R-HSA-171007 3.475769e-01 0.459 0 0
Interferon alpha/beta signaling R-HSA-909733 3.489618e-01 0.457 0 0
ABC transporter disorders R-HSA-5619084 3.493404e-01 0.457 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.559460e-01 0.449 0 0
Defective ABCD1 causes ALD R-HSA-5684045 3.559460e-01 0.449 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.559460e-01 0.449 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 3.559460e-01 0.449 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.559460e-01 0.449 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.559460e-01 0.449 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.559460e-01 0.449 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 3.631958e-01 0.440 0 0
Mitochondrial protein import R-HSA-1268020 3.653661e-01 0.437 0 0
Circadian clock R-HSA-9909396 3.664052e-01 0.436 0 0
Pyruvate metabolism R-HSA-70268 3.679741e-01 0.434 0 0
FGFR2 alternative splicing R-HSA-6803529 3.705722e-01 0.431 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 3.705722e-01 0.431 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.705722e-01 0.431 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.705722e-01 0.431 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.705722e-01 0.431 0 0
Signaling by KIT in disease R-HSA-9669938 3.705722e-01 0.431 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.723040e-01 0.429 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.772096e-01 0.423 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.772096e-01 0.423 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.772096e-01 0.423 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.802014e-01 0.420 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.802014e-01 0.420 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 3.802014e-01 0.420 0 0
ALK mutants bind TKIs R-HSA-9700645 3.802014e-01 0.420 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 3.802014e-01 0.420 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.802014e-01 0.420 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.802014e-01 0.420 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.802014e-01 0.420 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.802014e-01 0.420 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.802014e-01 0.420 0 0
Interleukin-21 signaling R-HSA-9020958 3.802014e-01 0.420 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.802014e-01 0.420 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.802014e-01 0.420 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.936310e-01 0.405 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.936310e-01 0.405 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.944155e-01 0.404 0 0
Pentose phosphate pathway R-HSA-71336 3.944155e-01 0.404 0 0
Signaling by ALK R-HSA-201556 3.944155e-01 0.404 0 0
RAS processing R-HSA-9648002 3.944155e-01 0.404 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.944155e-01 0.404 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.951590e-01 0.403 0 0
Syndecan interactions R-HSA-3000170 3.951590e-01 0.403 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.951590e-01 0.403 0 0
Ca2+ pathway R-HSA-4086398 4.004862e-01 0.397 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.061723e-01 0.391 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.061723e-01 0.391 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 4.065508e-01 0.391 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.065508e-01 0.391 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.065508e-01 0.391 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 4.070619e-01 0.390 0 0
Downstream TCR signaling R-HSA-202424 4.073204e-01 0.390 0 0
HIV Transcription Elongation R-HSA-167169 4.137152e-01 0.383 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.137152e-01 0.383 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.184475e-01 0.378 0 0
Binding and entry of HIV virion R-HSA-173107 4.184475e-01 0.378 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.184475e-01 0.378 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.184475e-01 0.378 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.184475e-01 0.378 0 0
PI3K/AKT activation R-HSA-198203 4.184475e-01 0.378 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.184475e-01 0.378 0 0
Signal attenuation R-HSA-74749 4.184475e-01 0.378 0 0
Interleukin-27 signaling R-HSA-9020956 4.184475e-01 0.378 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.184475e-01 0.378 0 0
Integration of energy metabolism R-HSA-163685 4.192313e-01 0.378 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.195876e-01 0.377 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.195876e-01 0.377 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.195876e-01 0.377 0 0
Post-translational protein phosphorylation R-HSA-8957275 4.226304e-01 0.374 0 0
MET activates STAT3 R-HSA-8875791 4.230403e-01 0.374 0 0
PLC-gamma1 signalling R-HSA-167021 4.230403e-01 0.374 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.230403e-01 0.374 0 0
Axonal growth stimulation R-HSA-209563 4.230403e-01 0.374 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.230403e-01 0.374 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.230403e-01 0.374 0 0
Signalling to STAT3 R-HSA-198745 4.230403e-01 0.374 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.230403e-01 0.374 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.230403e-01 0.374 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.230403e-01 0.374 0 0
MET interacts with TNS proteins R-HSA-8875513 4.230403e-01 0.374 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.230403e-01 0.374 0 0
Histamine receptors R-HSA-390650 4.230403e-01 0.374 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.230403e-01 0.374 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.275083e-01 0.369 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.275083e-01 0.369 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.354651e-01 0.361 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.368692e-01 0.360 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.398438e-01 0.357 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.437752e-01 0.353 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.437752e-01 0.353 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.487542e-01 0.348 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.520678e-01 0.345 0 0
Translation of Structural Proteins R-HSA-9683701 4.520678e-01 0.345 0 0
Signaling by APC mutants R-HSA-4839744 4.554548e-01 0.342 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.554548e-01 0.342 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.554548e-01 0.342 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.554548e-01 0.342 0 0
Chylomicron assembly R-HSA-8963888 4.554548e-01 0.342 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.554548e-01 0.342 0 0
Bicarbonate transporters R-HSA-425381 4.554548e-01 0.342 0 0
vRNP Assembly R-HSA-192905 4.554548e-01 0.342 0 0
Suppression of apoptosis R-HSA-9635465 4.554548e-01 0.342 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.554548e-01 0.342 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.561533e-01 0.341 0 0
Regulation of beta-cell development R-HSA-186712 4.561533e-01 0.341 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.604458e-01 0.337 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.638353e-01 0.334 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.638353e-01 0.334 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.638353e-01 0.334 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.638353e-01 0.334 0 0
Metabolism of proteins R-HSA-392499 4.638920e-01 0.334 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.676468e-01 0.330 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.676468e-01 0.330 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.676468e-01 0.330 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.697572e-01 0.328 0 0
Signal amplification R-HSA-392518 4.697572e-01 0.328 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.697572e-01 0.328 0 0
Signaling by NOTCH2 R-HSA-1980145 4.697572e-01 0.328 0 0
tRNA Aminoacylation R-HSA-379724 4.723740e-01 0.326 0 0
Potential therapeutics for SARS R-HSA-9679191 4.824993e-01 0.317 0 0
Alternative complement activation R-HSA-173736 4.831487e-01 0.316 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.831487e-01 0.316 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.831487e-01 0.316 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.831487e-01 0.316 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.831487e-01 0.316 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.831487e-01 0.316 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.831487e-01 0.316 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.831487e-01 0.316 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.831487e-01 0.316 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.831487e-01 0.316 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.831487e-01 0.316 0 0
Dopamine receptors R-HSA-390651 4.831487e-01 0.316 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.831487e-01 0.316 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.831487e-01 0.316 0 0
Toxicity of tetanus toxin (tetX) R-HSA-5250982 4.831487e-01 0.316 0 0
Formation of paraxial mesoderm R-HSA-9793380 4.884815e-01 0.311 0 0
Aquaporin-mediated transport R-HSA-445717 4.884815e-01 0.311 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.891431e-01 0.311 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.905019e-01 0.309 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.910663e-01 0.309 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.910663e-01 0.309 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.910663e-01 0.309 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.910663e-01 0.309 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.910663e-01 0.309 0 0
Signaling by AXIN mutants R-HSA-4839735 4.910663e-01 0.309 0 0
Sodium/Calcium exchangers R-HSA-425561 4.910663e-01 0.309 0 0
Cristae formation R-HSA-8949613 4.911353e-01 0.309 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.911353e-01 0.309 0 0
Insulin processing R-HSA-264876 4.911353e-01 0.309 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.915615e-01 0.308 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.915615e-01 0.308 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.915615e-01 0.308 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.915615e-01 0.308 0 0
The NLRP3 inflammasome R-HSA-844456 4.915615e-01 0.308 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.915615e-01 0.308 0 0
Maturation of nucleoprotein R-HSA-9694631 4.915615e-01 0.308 0 0
Inositol phosphate metabolism R-HSA-1483249 4.969495e-01 0.304 0 0
Proteasome assembly R-HSA-9907900 5.083826e-01 0.294 0 0
Amine ligand-binding receptors R-HSA-375280 5.083826e-01 0.294 0 0
RSV-host interactions R-HSA-9833110 5.103235e-01 0.292 0 0
Pyroptosis R-HSA-5620971 5.141811e-01 0.289 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.177661e-01 0.286 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 5.177661e-01 0.286 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 5.185602e-01 0.285 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.185602e-01 0.285 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.185602e-01 0.285 0 0
Signaling by NODAL R-HSA-1181150 5.185602e-01 0.285 0 0
Creatine metabolism R-HSA-71288 5.185602e-01 0.285 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.185602e-01 0.285 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.251712e-01 0.280 0 0
Polymerase switching R-HSA-69091 5.251712e-01 0.280 0 0
Leading Strand Synthesis R-HSA-69109 5.251712e-01 0.280 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.251712e-01 0.280 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.251712e-01 0.280 0 0
Repression of WNT target genes R-HSA-4641265 5.251712e-01 0.280 0 0
Interleukin-35 Signalling R-HSA-8984722 5.251712e-01 0.280 0 0
Signaling by LTK R-HSA-9842663 5.251712e-01 0.280 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.251712e-01 0.280 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.251712e-01 0.280 0 0
Somitogenesis R-HSA-9824272 5.266891e-01 0.278 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.266891e-01 0.278 0 0
Toll-like Receptor Cascades R-HSA-168898 5.362434e-01 0.271 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.367319e-01 0.270 0 0
Glucagon-type ligand receptors R-HSA-420092 5.367319e-01 0.270 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.369980e-01 0.270 0 0
G2 Phase R-HSA-68911 5.369980e-01 0.270 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.369980e-01 0.270 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.369980e-01 0.270 0 0
Defective F9 activation R-HSA-9673221 5.369980e-01 0.270 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.369980e-01 0.270 0 0
Activation of C3 and C5 R-HSA-174577 5.369980e-01 0.270 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.369980e-01 0.270 0 0
PTK6 Activates STAT3 R-HSA-8849474 5.369980e-01 0.270 0 0
PTK6 Down-Regulation R-HSA-8849472 5.369980e-01 0.270 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.369980e-01 0.270 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.369980e-01 0.270 0 0
Pyrophosphate hydrolysis R-HSA-71737 5.369980e-01 0.270 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.369980e-01 0.270 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.369980e-01 0.270 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.369980e-01 0.270 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.369980e-01 0.270 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.387044e-01 0.269 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 5.434449e-01 0.265 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.447118e-01 0.264 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.447627e-01 0.264 0 0
Lagging Strand Synthesis R-HSA-69186 5.447627e-01 0.264 0 0
G-protein activation R-HSA-202040 5.447627e-01 0.264 0 0
ERK/MAPK targets R-HSA-198753 5.447627e-01 0.264 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.447627e-01 0.264 0 0
Signalling to RAS R-HSA-167044 5.447627e-01 0.264 0 0
Cardiac conduction R-HSA-5576891 5.502580e-01 0.259 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.507619e-01 0.259 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.507619e-01 0.259 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.524900e-01 0.258 0 0
NRAGE signals death through JNK R-HSA-193648 5.563441e-01 0.255 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.576971e-01 0.254 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.576971e-01 0.254 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.576971e-01 0.254 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.576971e-01 0.254 0 0
Maturation of nucleoprotein R-HSA-9683610 5.576971e-01 0.254 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.587427e-01 0.253 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.587427e-01 0.253 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.587427e-01 0.253 0 0
Neuronal System R-HSA-112316 5.620299e-01 0.250 0 0
Neddylation R-HSA-8951664 5.658988e-01 0.247 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.700701e-01 0.244 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.700701e-01 0.244 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.701141e-01 0.244 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.701141e-01 0.244 0 0
Serine metabolism R-HSA-977347 5.701141e-01 0.244 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.798018e-01 0.237 0 0
Plus-strand DNA synthesis R-HSA-164525 5.852398e-01 0.233 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.852398e-01 0.233 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.852398e-01 0.233 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.852398e-01 0.233 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.852398e-01 0.233 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.852398e-01 0.233 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.852398e-01 0.233 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.852398e-01 0.233 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.852398e-01 0.233 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.852398e-01 0.233 0 0
Signaling by MST1 R-HSA-8852405 5.852398e-01 0.233 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.852398e-01 0.233 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.852398e-01 0.233 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.852398e-01 0.233 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.852398e-01 0.233 0 0
Removal of the Flap Intermediate R-HSA-69166 5.886026e-01 0.230 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.886026e-01 0.230 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.889390e-01 0.230 0 0
Diseases of Immune System R-HSA-5260271 5.889390e-01 0.230 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.945720e-01 0.226 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.945720e-01 0.226 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.945720e-01 0.226 0 0
DNA strand elongation R-HSA-69190 6.009972e-01 0.221 0 0
Peroxisomal protein import R-HSA-9033241 6.040521e-01 0.219 0 0
Triglyceride metabolism R-HSA-8979227 6.040521e-01 0.219 0 0
Erythropoietin activates RAS R-HSA-9027284 6.178724e-01 0.209 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.178724e-01 0.209 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.178724e-01 0.209 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.178724e-01 0.209 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.178724e-01 0.209 0 0
DNA Damage Reversal R-HSA-73942 6.178724e-01 0.209 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.178724e-01 0.209 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.178724e-01 0.209 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.181054e-01 0.209 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.181054e-01 0.209 0 0
Interleukin-20 family signaling R-HSA-8854691 6.181054e-01 0.209 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.181054e-01 0.209 0 0
Cardiogenesis R-HSA-9733709 6.211832e-01 0.207 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.279092e-01 0.202 0 0
Chylomicron clearance R-HSA-8964026 6.284576e-01 0.202 0 0
Signaling by LTK in cancer R-HSA-9842640 6.284576e-01 0.202 0 0
STAT5 Activation R-HSA-9645135 6.284576e-01 0.202 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.284576e-01 0.202 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.284576e-01 0.202 0 0
Uncoating of the HIV Virion R-HSA-162585 6.284576e-01 0.202 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.284576e-01 0.202 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.284576e-01 0.202 0 0
NADPH regeneration R-HSA-389542 6.284576e-01 0.202 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.284576e-01 0.202 0 0
MET Receptor Activation R-HSA-6806942 6.284576e-01 0.202 0 0
Lipid particle organization R-HSA-8964572 6.284576e-01 0.202 0 0
VLDL assembly R-HSA-8866423 6.284576e-01 0.202 0 0
HDL clearance R-HSA-8964011 6.284576e-01 0.202 0 0
Neurofascin interactions R-HSA-447043 6.284576e-01 0.202 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.352834e-01 0.197 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.390961e-01 0.194 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.406934e-01 0.193 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.407127e-01 0.193 0 0
Platelet homeostasis R-HSA-418346 6.452971e-01 0.190 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.455117e-01 0.190 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.455117e-01 0.190 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.455117e-01 0.190 0 0
Activation of SMO R-HSA-5635838 6.455117e-01 0.190 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.455117e-01 0.190 0 0
Killing mechanisms R-HSA-9664420 6.455117e-01 0.190 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.455117e-01 0.190 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.455117e-01 0.190 0 0
Signaling by PDGF R-HSA-186797 6.489279e-01 0.188 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.528805e-01 0.185 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.623240e-01 0.179 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.623240e-01 0.179 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.623240e-01 0.179 0 0
G protein gated Potassium channels R-HSA-1296059 6.623240e-01 0.179 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.623240e-01 0.179 0 0
TGFBR3 expression R-HSA-9839394 6.623240e-01 0.179 0 0
Formation of the nephric duct R-HSA-9830364 6.623240e-01 0.179 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 6.623240e-01 0.179 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.671744e-01 0.176 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.671744e-01 0.176 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.671744e-01 0.176 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.671744e-01 0.176 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.671744e-01 0.176 0 0
PTK6 Expression R-HSA-8849473 6.671744e-01 0.176 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.671744e-01 0.176 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.671744e-01 0.176 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.671744e-01 0.176 0 0
LDL remodeling R-HSA-8964041 6.671744e-01 0.176 0 0
VLDL clearance R-HSA-8964046 6.671744e-01 0.176 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.671744e-01 0.176 0 0
CHL1 interactions R-HSA-447041 6.671744e-01 0.176 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.671744e-01 0.176 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.671744e-01 0.176 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.687355e-01 0.175 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.715425e-01 0.173 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.715425e-01 0.173 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 6.715425e-01 0.173 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.715425e-01 0.173 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.715425e-01 0.173 0 0
Response to metal ions R-HSA-5660526 6.715425e-01 0.173 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.777468e-01 0.169 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.777468e-01 0.169 0 0
PERK regulates gene expression R-HSA-381042 6.777468e-01 0.169 0 0
Ion channel transport R-HSA-983712 6.822088e-01 0.166 1 0
TRP channels R-HSA-3295583 6.829930e-01 0.166 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.829930e-01 0.166 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.915389e-01 0.160 0 0
Iron uptake and transport R-HSA-917937 6.915389e-01 0.160 0 0
Innate Immune System R-HSA-168249 6.926047e-01 0.160 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.952351e-01 0.158 0 0
RNA Polymerase III Transcription R-HSA-74158 6.952351e-01 0.158 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.959999e-01 0.157 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.959999e-01 0.157 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.959999e-01 0.157 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.959999e-01 0.157 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.959999e-01 0.157 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.959999e-01 0.157 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.018588e-01 0.154 0 0
Minus-strand DNA synthesis R-HSA-164516 7.018588e-01 0.154 0 0
RSK activation R-HSA-444257 7.018588e-01 0.154 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.018588e-01 0.154 0 0
MET receptor recycling R-HSA-8875656 7.018588e-01 0.154 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.018588e-01 0.154 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.018588e-01 0.154 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.018588e-01 0.154 0 0
Regulation by c-FLIP R-HSA-3371378 7.018588e-01 0.154 0 0
Fructose biosynthesis R-HSA-5652227 7.018588e-01 0.154 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.018588e-01 0.154 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.018588e-01 0.154 0 0
Dimerization of procaspase-8 R-HSA-69416 7.018588e-01 0.154 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.018588e-01 0.154 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.018588e-01 0.154 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.027034e-01 0.153 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.027034e-01 0.153 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.058491e-01 0.151 0 0
Signaling by TGFBR3 R-HSA-9839373 7.071257e-01 0.151 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.071257e-01 0.151 0 0
Diseases of DNA repair R-HSA-9675135 7.071257e-01 0.151 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.159557e-01 0.145 0 0
Translation of Structural Proteins R-HSA-9694635 7.159557e-01 0.145 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.160530e-01 0.145 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.189290e-01 0.143 0 0
Polo-like kinase mediated events R-HSA-156711 7.189290e-01 0.143 0 0
Platelet sensitization by LDL R-HSA-432142 7.189290e-01 0.143 0 0
Mismatch Repair R-HSA-5358508 7.189290e-01 0.143 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.189290e-01 0.143 0 0
Nephron development R-HSA-9831926 7.189290e-01 0.143 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.189290e-01 0.143 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.196451e-01 0.143 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.214638e-01 0.142 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.214638e-01 0.142 0 0
Inflammasomes R-HSA-622312 7.214638e-01 0.142 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.222524e-01 0.141 0 0
CASP8 activity is inhibited R-HSA-5218900 7.329304e-01 0.135 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.329304e-01 0.135 0 0
Unwinding of DNA R-HSA-176974 7.329304e-01 0.135 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.329304e-01 0.135 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.329304e-01 0.135 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.329304e-01 0.135 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.329304e-01 0.135 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.329304e-01 0.135 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.329304e-01 0.135 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.329304e-01 0.135 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.329304e-01 0.135 0 0
NGF-stimulated transcription R-HSA-9031628 7.361204e-01 0.133 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.389904e-01 0.131 0 0
mRNA Capping R-HSA-72086 7.392881e-01 0.131 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.403827e-01 0.131 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.403827e-01 0.131 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.403827e-01 0.131 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.403827e-01 0.131 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.403827e-01 0.131 0 0
Gastrulation R-HSA-9758941 7.425544e-01 0.129 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 7.435701e-01 0.129 0 0
Interferon gamma signaling R-HSA-877300 7.440090e-01 0.128 0 0
Extension of Telomeres R-HSA-180786 7.444430e-01 0.128 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.495225e-01 0.125 0 0
DAP12 signaling R-HSA-2424491 7.561944e-01 0.121 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.561944e-01 0.121 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.561944e-01 0.121 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.583205e-01 0.120 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.583205e-01 0.120 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.595072e-01 0.119 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.607655e-01 0.119 0 0
Formation of apoptosome R-HSA-111458 7.607655e-01 0.119 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.607655e-01 0.119 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.607655e-01 0.119 0 0
DNA replication initiation R-HSA-68952 7.607655e-01 0.119 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.607655e-01 0.119 0 0
Sperm Motility And Taxes R-HSA-1300642 7.607655e-01 0.119 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.607655e-01 0.119 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.607655e-01 0.119 0 0
PI3K Cascade R-HSA-109704 7.629615e-01 0.117 0 0
Stimuli-sensing channels R-HSA-2672351 7.658737e-01 0.116 1 1
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.661930e-01 0.116 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.686997e-01 0.114 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 7.724047e-01 0.112 0 0
Mitochondrial biogenesis R-HSA-1592230 7.738855e-01 0.111 0 0
The phototransduction cascade R-HSA-2514856 7.755849e-01 0.110 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.791014e-01 0.108 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.801671e-01 0.108 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 7.854302e-01 0.105 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.857009e-01 0.105 0 0
vRNA Synthesis R-HSA-192814 7.857009e-01 0.105 0 0
Conjugation of benzoate with glycine R-HSA-177135 7.857009e-01 0.105 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.857009e-01 0.105 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.857009e-01 0.105 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.857009e-01 0.105 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.857009e-01 0.105 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.857009e-01 0.105 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.858349e-01 0.105 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.858349e-01 0.105 0 0
Signaling by WNT in cancer R-HSA-4791275 7.873429e-01 0.104 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.873429e-01 0.104 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.911996e-01 0.102 0 0
Signaling by FGFR in disease R-HSA-1226099 7.955801e-01 0.099 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.964933e-01 0.099 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.964933e-01 0.099 0 0
Ribavirin ADME R-HSA-9755088 7.964933e-01 0.099 0 0
Activation of GABAB receptors R-HSA-991365 7.986251e-01 0.098 0 0
GABA B receptor activation R-HSA-977444 7.986251e-01 0.098 0 0
Nuclear RNA decay R-HSA-9930044 8.016368e-01 0.096 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.016368e-01 0.096 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.016368e-01 0.096 0 0
IGF1R signaling cascade R-HSA-2428924 8.018032e-01 0.096 0 0
Mitochondrial protein degradation R-HSA-9837999 8.054613e-01 0.094 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.080387e-01 0.093 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.080387e-01 0.093 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.080387e-01 0.093 0 0
Plasmalogen biosynthesis R-HSA-75896 8.080387e-01 0.093 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.080387e-01 0.093 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.080387e-01 0.093 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.094942e-01 0.092 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.119843e-01 0.090 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.126611e-01 0.090 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.126611e-01 0.090 0 0
Fructose metabolism R-HSA-5652084 8.126611e-01 0.090 0 0
LDL clearance R-HSA-8964038 8.126611e-01 0.090 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.126611e-01 0.090 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.151149e-01 0.089 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.182586e-01 0.087 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.276710e-01 0.082 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 8.276710e-01 0.082 0 0
eNOS activation R-HSA-203615 8.278074e-01 0.082 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.278074e-01 0.082 0 0
RA biosynthesis pathway R-HSA-5365859 8.278074e-01 0.082 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.278074e-01 0.082 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.280492e-01 0.082 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.280492e-01 0.082 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.280492e-01 0.082 0 0
Conjugation of salicylate with glycine R-HSA-177128 8.280492e-01 0.082 0 0
Interleukin-15 signaling R-HSA-8983432 8.280492e-01 0.082 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.280492e-01 0.082 0 0
Synthesis of GDP-mannose R-HSA-446205 8.280492e-01 0.082 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.280492e-01 0.082 0 0
OAS antiviral response R-HSA-8983711 8.280492e-01 0.082 0 0
Post-translational protein modification R-HSA-597592 8.296164e-01 0.081 0 0
Parasitic Infection Pathways R-HSA-9824443 8.372884e-01 0.077 0 0
Leishmania infection R-HSA-9658195 8.372884e-01 0.077 0 0
IRS-mediated signalling R-HSA-112399 8.406881e-01 0.075 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.415885e-01 0.075 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.437132e-01 0.074 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.437132e-01 0.074 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.459748e-01 0.073 0 0
Chylomicron remodeling R-HSA-8963901 8.459748e-01 0.073 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.459748e-01 0.073 0 0
Processing of SMDT1 R-HSA-8949664 8.459748e-01 0.073 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.459748e-01 0.073 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.459748e-01 0.073 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.459748e-01 0.073 0 0
Rab regulation of trafficking R-HSA-9007101 8.508267e-01 0.070 0 0
GPVI-mediated activation cascade R-HSA-114604 8.509606e-01 0.070 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.544783e-01 0.068 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.620327e-01 0.064 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.620327e-01 0.064 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.620327e-01 0.064 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.620327e-01 0.064 0 0
Prolactin receptor signaling R-HSA-1170546 8.620327e-01 0.064 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.620327e-01 0.064 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.620327e-01 0.064 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.620327e-01 0.064 0 0
MET activates PTK2 signaling R-HSA-8874081 8.664033e-01 0.062 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.664033e-01 0.062 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.669120e-01 0.062 0 0
Signaling by Retinoic Acid R-HSA-5362517 8.669120e-01 0.062 0 0
Metabolism of polyamines R-HSA-351202 8.669120e-01 0.062 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.711287e-01 0.060 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.713511e-01 0.060 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.764173e-01 0.057 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.764173e-01 0.057 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.764173e-01 0.057 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.764173e-01 0.057 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.764173e-01 0.057 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.764173e-01 0.057 0 0
Protein repair R-HSA-5676934 8.764173e-01 0.057 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 8.764173e-01 0.057 0 0
Signaling by Activin R-HSA-1502540 8.764173e-01 0.057 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.774245e-01 0.057 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 8.774245e-01 0.057 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 8.774245e-01 0.057 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.799815e-01 0.056 0 0
Azathioprine ADME R-HSA-9748787 8.799815e-01 0.056 0 0
Adipogenesis R-HSA-9843745 8.821879e-01 0.054 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.822941e-01 0.054 0 0
Telomere Extension By Telomerase R-HSA-171319 8.876008e-01 0.052 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.876008e-01 0.052 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.876008e-01 0.052 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.892336e-01 0.051 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.893029e-01 0.051 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.893029e-01 0.051 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.893029e-01 0.051 0 0
Fructose catabolism R-HSA-70350 8.893029e-01 0.051 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.893029e-01 0.051 0 0
Differentiation of T cells R-HSA-9945266 8.893029e-01 0.051 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.893029e-01 0.051 0 0
Attachment and Entry R-HSA-9678110 8.893029e-01 0.051 0 0
Virus Assembly and Release R-HSA-168268 8.893029e-01 0.051 0 0
Insulin receptor signalling cascade R-HSA-74751 8.961297e-01 0.048 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.969884e-01 0.047 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.006131e-01 0.045 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.008456e-01 0.045 0 0
Passive transport by Aquaporins R-HSA-432047 9.008456e-01 0.045 0 0
Galactose catabolism R-HSA-70370 9.008456e-01 0.045 0 0
Coenzyme A biosynthesis R-HSA-196783 9.008456e-01 0.045 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.008456e-01 0.045 0 0
Nucleotide biosynthesis R-HSA-8956320 9.021622e-01 0.045 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.048570e-01 0.043 0 0
HIV Transcription Initiation R-HSA-167161 9.048570e-01 0.043 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.048570e-01 0.043 0 0
Intra-Golgi traffic R-HSA-6811438 9.048570e-01 0.043 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.048570e-01 0.043 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.056412e-01 0.043 0 0
SLC transporter disorders R-HSA-5619102 9.091384e-01 0.041 0 0
Integrin cell surface interactions R-HSA-216083 9.100224e-01 0.041 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.111853e-01 0.040 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.111853e-01 0.040 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.111853e-01 0.040 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.111853e-01 0.040 0 0
Choline catabolism R-HSA-6798163 9.111853e-01 0.040 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.111853e-01 0.040 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.117575e-01 0.040 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.118963e-01 0.040 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.136102e-01 0.039 0 0
Kidney development R-HSA-9830369 9.142360e-01 0.039 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.152884e-01 0.038 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.184589e-01 0.037 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.204474e-01 0.036 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.204474e-01 0.036 0 0
Tie2 Signaling R-HSA-210993 9.204474e-01 0.036 0 0
DAP12 interactions R-HSA-2172127 9.245722e-01 0.034 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.250198e-01 0.034 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.253652e-01 0.034 0 0
Parasite infection R-HSA-9664407 9.253652e-01 0.034 0 0
Leishmania phagocytosis R-HSA-9664417 9.253652e-01 0.034 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.263367e-01 0.033 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.287441e-01 0.032 0 0
Specification of the neural plate border R-HSA-9834899 9.287441e-01 0.032 0 0
Amino Acid conjugation R-HSA-156587 9.287441e-01 0.032 0 0
Conjugation of carboxylic acids R-HSA-159424 9.287441e-01 0.032 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.287441e-01 0.032 0 0
Diseases of hemostasis R-HSA-9671793 9.287441e-01 0.032 0 0
HDL remodeling R-HSA-8964058 9.287441e-01 0.032 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.287441e-01 0.032 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.287441e-01 0.032 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.302626e-01 0.031 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.311523e-01 0.031 0 0
Heme degradation R-HSA-189483 9.338863e-01 0.030 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.338863e-01 0.030 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.361759e-01 0.029 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.361759e-01 0.029 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.361759e-01 0.029 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.361759e-01 0.029 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.361759e-01 0.029 0 0
Pregnenolone biosynthesis R-HSA-196108 9.361759e-01 0.029 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.395785e-01 0.027 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.400663e-01 0.027 0 0
GABA receptor activation R-HSA-977443 9.403897e-01 0.027 0 0
Synthesis of PC R-HSA-1483191 9.404752e-01 0.027 0 0
PPARA activates gene expression R-HSA-1989781 9.410884e-01 0.026 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.413570e-01 0.026 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.428330e-01 0.026 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.428330e-01 0.026 0 0
Abacavir metabolism R-HSA-2161541 9.428330e-01 0.026 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.428330e-01 0.026 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.448031e-01 0.025 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.450449e-01 0.025 0 0
Heme signaling R-HSA-9707616 9.484839e-01 0.023 0 0
Attachment and Entry R-HSA-9694614 9.487961e-01 0.023 0 0
RUNX2 regulates bone development R-HSA-8941326 9.495955e-01 0.022 0 0
Glycosphingolipid transport R-HSA-9845576 9.495955e-01 0.022 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.495955e-01 0.022 0 0
tRNA processing R-HSA-72306 9.533822e-01 0.021 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.539891e-01 0.020 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.541375e-01 0.020 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.541375e-01 0.020 0 0
G alpha (s) signalling events R-HSA-418555 9.555588e-01 0.020 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.580149e-01 0.019 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.589219e-01 0.018 0 0
Formation of the ureteric bud R-HSA-9830674 9.589219e-01 0.018 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.589219e-01 0.018 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.589219e-01 0.018 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.617018e-01 0.017 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.632075e-01 0.016 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.632075e-01 0.016 0 0
Complex III assembly R-HSA-9865881 9.632075e-01 0.016 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.632075e-01 0.016 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.633799e-01 0.016 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.650768e-01 0.015 0 0
Interleukin-2 family signaling R-HSA-451927 9.650768e-01 0.015 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.650768e-01 0.015 0 0
Tryptophan catabolism R-HSA-71240 9.650768e-01 0.015 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.670463e-01 0.015 0 0
Hyaluronan degradation R-HSA-2160916 9.670463e-01 0.015 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.670463e-01 0.015 0 0
Fertilization R-HSA-1187000 9.670463e-01 0.015 0 0
Laminin interactions R-HSA-3000157 9.670463e-01 0.015 0 0
Signaling by Insulin receptor R-HSA-74752 9.674753e-01 0.014 0 0
Extracellular matrix organization R-HSA-1474244 9.696802e-01 0.013 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.704847e-01 0.013 0 0
Urea cycle R-HSA-70635 9.704847e-01 0.013 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.704847e-01 0.013 0 0
Abacavir ADME R-HSA-2161522 9.704847e-01 0.013 0 0
Sphingolipid catabolism R-HSA-9845614 9.704847e-01 0.013 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.735645e-01 0.012 0 0
Dectin-2 family R-HSA-5621480 9.737230e-01 0.012 0 0
Insulin receptor recycling R-HSA-77387 9.763231e-01 0.010 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.763231e-01 0.010 0 0
Pyrimidine salvage R-HSA-73614 9.763231e-01 0.010 0 0
Prednisone ADME R-HSA-9757110 9.763231e-01 0.010 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.777893e-01 0.010 0 0
Surfactant metabolism R-HSA-5683826 9.780833e-01 0.010 0 0
Thyroxine biosynthesis R-HSA-209968 9.787940e-01 0.009 0 0
RAB geranylgeranylation R-HSA-8873719 9.795904e-01 0.009 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.807163e-01 0.008 0 0
Neurotransmitter clearance R-HSA-112311 9.810072e-01 0.008 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.810072e-01 0.008 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.825502e-01 0.008 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.829895e-01 0.007 0 0
Neurotransmitter release cycle R-HSA-112310 9.839434e-01 0.007 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.839434e-01 0.007 0 0
Formation of the cornified envelope R-HSA-6809371 9.840800e-01 0.007 0 0
Metal ion SLC transporters R-HSA-425410 9.849780e-01 0.007 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.863402e-01 0.006 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.863553e-01 0.006 0 0
Recycling of bile acids and salts R-HSA-159418 9.863553e-01 0.006 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.875818e-01 0.005 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.877797e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.877797e-01 0.005 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.882238e-01 0.005 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.882238e-01 0.005 0 0
Complex IV assembly R-HSA-9864848 9.887132e-01 0.005 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.888080e-01 0.005 0 0
Hyaluronan metabolism R-HSA-2142845 9.890554e-01 0.005 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.890554e-01 0.005 0 0
Peptide hormone metabolism R-HSA-2980736 9.891636e-01 0.005 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.901980e-01 0.004 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.901980e-01 0.004 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.912215e-01 0.004 0 0
Potassium Channels R-HSA-1296071 9.912260e-01 0.004 0 0
Retinoid metabolism and transport R-HSA-975634 9.921101e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.921101e-01 0.003 0 0
Voltage gated Potassium channels R-HSA-1296072 9.921381e-01 0.003 0 0
NCAM1 interactions R-HSA-419037 9.921381e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.921381e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.921381e-01 0.003 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.929590e-01 0.003 0 0
Elastic fibre formation R-HSA-1566948 9.929590e-01 0.003 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.929590e-01 0.003 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.934487e-01 0.003 0 0
Synthesis of PA R-HSA-1483166 9.936654e-01 0.003 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.943528e-01 0.002 0 0
PI Metabolism R-HSA-1483255 9.944906e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.946289e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.947830e-01 0.002 0 0
Maturation of spike protein R-HSA-9694548 9.949426e-01 0.002 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.954708e-01 0.002 0 0
Heme biosynthesis R-HSA-189451 9.954708e-01 0.002 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.954943e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.957622e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.957622e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.961258e-01 0.002 0 0
Pyrimidine catabolism R-HSA-73621 9.963676e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.965453e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.967470e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.967643e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.973057e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.974615e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.976163e-01 0.001 0 0
Metabolism of nucleotides R-HSA-15869 9.976325e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.976638e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.977076e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.978402e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.978402e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.979257e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.982275e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.982275e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.983947e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.983947e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.983947e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.986837e-01 0.001 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.988083e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.989058e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.989212e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.990340e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.990498e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.990712e-01 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.991025e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.991349e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.995020e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.995020e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.995620e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.996007e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.996065e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.996065e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.996174e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.996425e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.997133e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997433e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998523e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.998816e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999239e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999294e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999457e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999768e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999834e-01 0.000 1 0
FCGR activation R-HSA-2029481 9.999884e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999887e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999909e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999914e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999925e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999926e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999940e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999966e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999976e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999979e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999980e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999984e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999985e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999986e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999987e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999990e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999992e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999993e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999993e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999998e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999998e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999998e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways