JAK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A1L429 Y10 Sugiyama GAGE12B; GAGE12C; GAGE12D; GAGE12E ___________MSWRGRsTyyWPRPRRYVQPPEMIGPMRPE
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
A6NDE8 Y10 Sugiyama GAGE12H ___________MSWRGRsTyyWPRPRRYVQPPEMIGPMRPE
A6NER3 Y10 Sugiyama GAGE12J ___________MSWRGRsTyyWPRPRPYVQPPEMIGPMRPE
O00299 Y233 Sugiyama CLIC1 G6 NCC27 AyAREEFAstCPDDEEIELAyEQVAKALK____________
O14910 S135 Sugiyama LIN7A MALS1 VELI1 DEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLKRGDQL
O14910 Y133 Sugiyama LIN7A MALS1 VELI1 KTDEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLKRGD
O14950 Y156 Sugiyama MYL12B MRLC2 MYLC2B DEEVDELyREAPIDKKGNFNyIEFtRILKHGAKDKDD____
O14979 Y167 Sugiyama HNRNPDL HNRPDL JKTBP DGKMFIGGLSWDTsKKDLtEyLSRFGEVVDCtIKTDPVTGR
O43707 Y212 Sugiyama ACTN4 WKDGLAFNALIHRHRPELIEyDKLRKDDPVTNLNNAFEVAE
O43852 Y263 Sugiyama CALU KNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNKDG
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60664 Y95 Sugiyama PLIN3 M6PRBP1 TIP47 VsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQPTE
O60739 Y30 Sugiyama EIF1B FDPFADATKGDDLLPAGTEDyIHIRIQQRNGRKtLttVQGI
O60814 Y41 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
O60814 Y43 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
O75347 Y75 Sugiyama TBCA EILQEsRMMIPDCQRRLEAAyLDLQRILENEKDLEEAEEyK
O76087 Y10 Sugiyama GAGE7 GAGE12I GAGE7B ___________MSWRGRsTyyWPRPRRYVQPPEMIGPMRPE
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
O95817 T242 Sugiyama BAG3 BIS QPsFHQAQKTHyPAQQGEyQtHQPVyHKIQGDDWEPRPLRA
P00338 Y239 Sugiyama LDHA PIG19 GtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVADL
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P02786 Y152 Sugiyama TFRC sEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVENQ
P04080 Y97 Sugiyama CSTB CST6 STFB NKPLtLsNyQTNKAKHDELtyF___________________
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05362 Y455 Sugiyama ICAM1 GtFPLPIGEsVtVtRDLEGtyLCRARSTQGEVTRKVTVNVL
P06733 Y189 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 MILPVGAANFREAMRIGAEVyHNLKNVIKEKyGKDAtNVGD
P06733 Y270 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P06733 Y280 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 DFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDD
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07437 Y51 Sugiyama TUBB TUBB5 OK/SW-cl.56 DPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPG
P07711 Y311 Sugiyama CTSL CTSL1 DNNKYWLVKNsWGEEWGMGGyVKMAKDRRNHCGIAsAAsyP
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900 Y313 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P07900 Y465 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IKLGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMK
P07900 Y466 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA KLGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKE
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238 Y472 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB sELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEsKE
P08238 Y484 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P08238 Y485 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB EMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRK
P08758 Y94 Sugiyama ANXA5 ANX5 ENX2 PP4 TGKFEKLIVALMKPSRLyDAyELKHALKGAGTNEKVLtEII
P09651 Y341 Sugiyama HNRNPA1 HNRPA1 QSSNFGPMKGGNFGGRssGPyGGGGQyFAKPRNQGGyGGss
P09651 Y347 Sugiyama HNRNPA1 HNRPA1 PMKGGNFGGRssGPyGGGGQyFAKPRNQGGyGGssssssyG
P0CL80 Y10 Sugiyama GAGE12F ___________MSWRGRsTyyWPRPRRYVQPPEMIGPMRPE
P0DSO3 Y10 Sugiyama GAGE4 ___________MSWRGRsTyyWPRPRRYVQPPEMIGPMRPE
P10721 S943 Sugiyama KIT SCFR LIEKQISEstNHIysNLANCsPNRQKPVVDHSVRINsVGst
P10721 Y936 Sugiyama KIT SCFR TFKQIVQLIEKQISEstNHIysNLANCsPNRQKPVVDHSVR
P10809 Y223 Sugiyama HSPD1 HSP60 DGKtLNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAy
P10809 Y227 Sugiyama HSPD1 HSP60 LNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLs
P10809 Y243 Sugiyama HSPD1 HSP60 yIsPyFINtsKGQKCEFQDAyVLLsEKKIssIQsIVPALEI
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 S544 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KYKAEDEKQRDKVssKNsLEsyAFNMKATVEDEKLQGKIND
P11142 Y134 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FYPEEVSSMVLTKMKEIAEAyLGKtVTNAVVtVPAyFNDsQ
P11142 Y545 Sugiyama HSPA8 HSC70 HSP73 HSPA10 YKAEDEKQRDKVssKNsLEsyAFNMKATVEDEKLQGKINDE
P11940 Y194 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 KSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLFGKF
P11940 Y291 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 ERQTELKRKFEQMKQDRITRyQGVNLyVKNLDDGIDDERLR
P11940 Y297 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 KRKFEQMKQDRITRyQGVNLyVKNLDDGIDDERLRKEFsPF
P13073 Y38 Sugiyama COX4I1 COX4 SVCVRAHESVVKsEDFsLPAyMDRRDHPLPEVAHVKHLSAS
P13639 Y443 Sugiyama EEF2 EF2 TGLKVRIMGPNytPGKKEDLyLKPIQRTILMMGRYVEPIED
P13674 Y282 Sugiyama P4HA1 P4HA ASDDQSDQKTTPKKKGVAVDyLPERQKyEMLCRGEGIKMTP
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 Y106 Sugiyama PRKCSH G19P1 yIPSNRVNDGVCDCCDGtDEyNsGVICENtCKEKGRKEREs
P14625 Y401 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 VTFKSILFVPTSAPRGLFDEyGsKKSDYIKLYVRRVFITDD
P14784 Y364 SIGNOR|iPTMNet|EPSD IL2RB IL15RB PEPASLSSNHSLTSCFTNQGyFFFHLPDALEIEACQVyFTy
P14784 Y418 SIGNOR IL2RB IL15RB GAPTGSSPQPLQPLSGEDDAyCTFPSRDDLLLFSPSLLGGP
P14784 Y536 SIGNOR IL2RB IL15RB PPGQGEFRALNARLPLNtDAyLSLQELQGQDPTHLV_____
P15260 Y457 GPS6|SIGNOR|ELM|iPTMNet|EPSD IFNGR1 EIKTEGQELITVIKAPTSFGyDKPHVLVDLLVDDSGKESLI
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17676 Y139 Sugiyama CEBPB TCF5 PP9092 SDLFSDDYGGKNCKKPAEyGyVsLGRLGAAKGALHPGCFAP
P18206 Y822 Sugiyama VCL KAVAGNIsDPGLQKsFLDsGyRILGAVAKVREAFQPQEPDF
P19105 Y155 Sugiyama MYL12A MLCB MRLC3 RLC DEEVDELyREAPIDKKGNFNyIEFtRILKHGAKDKDD____
P19338 Y462 Sugiyama NCL AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P19525 Y101 iPTMNet|EPSD EIF2AK2 PKR PRKR AVsPLLLtttNssEGLsMGNyIGLINRIAQKKRLTVNYEQC
P19525 Y293 iPTMNet|EPSD EIF2AK2 PKR PRKR IGSGGFGQVFKAKHRIDGKTyVIKRVKYNNEKAEREVKALA
P22234 Y22 Sugiyama PAICS ADE2 AIRC PAIS AtAEVLNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAG
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23434 Y139 Sugiyama GCSH EVTEINEALAENPGLVNKSCyEDGWLIKMtLsNPsELDELM
P23458 T901 Sugiyama JAK1 JAK1A JAK1B LGEGHFGKVELCRyDPEGDNtGEQVAVKSLKPESGGNHIAD
P23458 Y1034 Sugiyama JAK1 JAK1A JAK1B EHQVKIGDFGLTKAIETDKEyyTVKDDRDSPVFWYAPECLM
P23458 Y1035 Sugiyama JAK1 JAK1A JAK1B HQVKIGDFGLTKAIETDKEyyTVKDDRDSPVFWYAPECLMQ
P23458 Y894 Sugiyama JAK1 JAK1A JAK1B FLKRIRDLGEGHFGKVELCRyDPEGDNtGEQVAVKSLKPES
P23458 Y933 Sugiyama JAK1 JAK1A JAK1B ESGGNHIADLKKEIEILRNLyHENIVKYKGICTEDGGNGIK
P23458 Y993 Sugiyama JAK1 JAK1A JAK1B NKINLKQQLKYAVQICKGMDyLGSRQYVHRDLAARNVLVES
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23528 Y140 Sugiyama CFL1 CFL SKDAIKKKLtGIKHELQANCyEEVKDRCTLAEKLGGsAVIs
P24752 Y90 Sugiyama ACAT1 ACAT MAT IAIQGAIEKAGIPKEEVKEAyMGNVLQGGEGQAPTRQAVLG
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P27348 Y149 Sugiyama YWHAQ LAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHPIRLG
P27348 Y48 Sugiyama YWHAQ AVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSIEQK
P27540 Y561 Sugiyama ARNT BHLHE2 PLEKSDGLFAQDRDPRFsEIyHNINADQSKGISSSTVPATQ
P27695 Y128 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 LQELPGLSHQYWSAPsDKEGysGVGLLsRQCPLKVsyGIGD
P27797 Y109 Sugiyama CALR CRTC QTLVVQFTVKHEQNIDCGGGyVKLFPNSLDQTDMHGDSEYN
P27816 Y47 Sugiyama MAP4 AtLEAEAFDDVVGETVGKTDyIPLLDVDEKtGNsESKKKPC
P29353 Y427 Sugiyama SHC1 SHC SHCA RKQMPPPPPCPGRELFDDPsyVNVQNLDKARQAVGGAGPPN
P29597 Y1054 GPS6|SIGNOR|ELM|iPTMNet|EPSD TYK2 DRLVKIGDFGLAKAVPEGHEyyRVREDGDsPVFWyAPECLK
P29597 Y1055 GPS6|SIGNOR|ELM|iPTMNet|EPSD TYK2 RLVKIGDFGLAKAVPEGHEyyRVREDGDsPVFWyAPECLKE
P29692 Y26 Sugiyama EEF1D EF1D LAHEKIWFDKFKYDDAERRFyEQMNGPVAGAsRQENGAsVI
P30086 S104 Sugiyama PEBP1 PBP PEBP WHHFLVVNMKGNDIssGtVLsDyVGsGPPKGtGLHRyVWLV
P30086 Y176 Sugiyama PEBP1 PBP PEBP KKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK_________
P30086 Y64 Sugiyama PEBP1 PBP PEBP tQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREW
P30101 Y115 Sugiyama PDIA3 ERP57 ERP60 GRP58 yGVsGyPtLKIFRDGEEAGAyDGPRtADGIVsHLKKQAGPA
P30101 Y356 Sugiyama PDIA3 ERP57 ERP60 GRP58 FVMQEEFsRDGKALERFLQDyFDGNLKRyLKsEPIPESNDG
P30101 Y67 Sugiyama PDIA3 ERP57 ERP60 GRP58 LMLVEFFAPWCGHCKRLAPEyEAAAtRLKGIVPLAKVDCTA
P31943 Y266 Sugiyama HNRNPH1 HNRPH HNRPH1 yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P31946 Y50 Sugiyama YWHAB AVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P31947 Y48 Sugiyama SFN HME1 GAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsIEQK
P31948 Y354 Sugiyama STIP1 DVLKKCQQAEKILKEQERLAyINPDLALEEKNKGNECFQKG
P31948 Y41 Sugiyama STIP1 DDALQCysEAIKLDPHNHVLysNRsAAyAKKGDYQKAyEDG
P32119 Y115 Sugiyama PRDX2 NKEFB TDPX1 GLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFIIDGK
P32929 S61 Sugiyama CTH ISLSTTFKQGAPGQHsGFEysRsGNPTRNCLEKAVAALDGA
P32969 Y180 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P33316 Y167 Sugiyama DUT PPMEKAVVKTDIQIALPsGCyGRVAPRSGLAAKHFIDVGAG
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932 S31 Sugiyama HSPA4 APG2 HSPH2 QSCYVAVARAGGIETIANEysDRCtPACIsFGPKNRSIGAA
P34932 Y597 Sugiyama HSPA4 APG2 HSPH2 VDLPIENQLLWQIDREMLNLyIENEGKMIMQDKLEKERNDA
P35568 Y612 iPTMNet|EPSD IRS1 LERRGGHHRPDsstLHtDDGyMPMsPGVAPVPSGRKGsGDy
P35568 Y632 iPTMNet|EPSD IRS1 yMPMsPGVAPVPSGRKGsGDyMPMsPKsVSAPQQIINPIRR
P35568 Y662 iPTMNet|EPSD IRS1 APQQIINPIRRHPQRVDPNGyMMMSPSGGCSPDIGGGPSSS
P35568 Y732 iPTMNet|EPSD IRS1 PHPKPPVESSGGKLLPCTGDyMNMSPVGDSNTSSPSDCYYG
P37802 Y192 Sugiyama TAGLN2 KIAA0120 CDABP0035 NVIGLQMGtNRGAsQAGMtGyGMPRQIL_____________
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P40763 Y705 SIGNOR|EPSD STAT3 APRF KyCRPEsQEHPEADPGsAAPyLKTKFICVtPttCsNtIDLP
P41567 Y30 Sugiyama EIF1 SUI1 FDPFADAsKGDDLLPAGTEDyIHIRIQQRNGRKtLttVQGI
P42224 Y701 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP STAT1 YSRPKEAPEPMELDGPKGtGyIKtELIsVsEVHPSRLQttD
P42226 Y641 ELM STAT6 KDEAFRSHYKPEQMGKDGRGyVPATIKMTVERDQPLPTPEL
P42229 Y694 PSP STAT5A STAT5 PKDEVFSKYYTPVLAKAVDGyVKPQIKQVVPEFVNASADAG
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46776 Y52 Sugiyama RPL27A RGNAGGLHHHRINFDKyHPGyFGKVGMKHYHLKRNQsFCPt
P46777 Y207 Sugiyama RPL5 MSTP030 sKEFNAEVHRKHIMGQNVADyMRyLMEEDEDAyKKQFsQyI
P47224 Y114 Sugiyama RABIF MSS4 RASGRF3 CADCEIGPIGWHCLDDKNSFyVALERVSHE___________
P47756 Y232 Sugiyama CAPZB NIGRLVEDMENKIRstLNEIyFGKTKDIVNGLRSVQTFADK
P47914 Y98 Sugiyama RPL29 PKEVKPKIPKGVSRKLDRLAyIAHPKLGKRARARIAKGLRL
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49207 T35 Sugiyama RPL34 tASNKTRLSRTPGNRIVyLytKKVGKAPKSACGVCPGRLRG
P49207 Y32 Sugiyama RPL34 sYNtASNKTRLSRTPGNRIVyLytKKVGKAPKSACGVCPGR
P50990 Y30 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 GFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTTRTAYGPN
P52630 Y690 SIGNOR|ELM|iPTMNet|EPSD STAT2 RDEAFGCYYQEKVNLQERRKyLKHRLIVVSNRQVDELQQPL
P53634 Y438 Sugiyama CTSC CPPI SGMDYWIVKNsWGtGWGENGyFRIRRGtDECAIEsIAVAAt
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55060 Y369 Sugiyama CSE1L CAS XPO2 VPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAACDL
P55795 Y266 Sugiyama HNRNPH2 FTP3 HNRPH2 YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P57053 Y41 Sugiyama H2BC12L H2BFS H2BS1 KAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
P57053 Y43 Sugiyama H2BC12L H2BFS H2BS1 QKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
P58876 Y41 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
P58876 Y43 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
P60660 Y89 Sugiyama MYL6 HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60842 Y70 Sugiyama EIF4A1 DDX2A EIF4A yGFEKPsAIQQRAILPCIKGyDVIAQAQsGtGKTATFAISI
P61024 Y7 Sugiyama CKS1B CKS1 PNAS-143 PNAS-16 ______________MSHKQIyysDKyDDEEFEyRHVMLPKD
P61081 Y172 Sugiyama UBE2M UBC12 VLQNNRRLFEQNVQRSMRGGyIGstyFERCLK_________
P61081 Y177 Sugiyama UBE2M UBC12 RRLFEQNVQRSMRGGyIGstyFERCLK______________
P61247 Y256 Sugiyama RPS3A FTE1 MFTL sssGKAtGDEtGAKVERADGyEPPVQEsV____________
P61604 T79 Sugiyama HSPE1 EIQPVsVKVGDKVLLPEyGGtKVVLDDKDyFLFRDGDILGK
P61604 Y100 Sugiyama HSPE1 KVVLDDKDyFLFRDGDILGKyVD__________________
P61604 Y88 Sugiyama HSPE1 GDKVLLPEyGGtKVVLDDKDyFLFRDGDILGKyVD______
P61981 Y49 Sugiyama YWHAG NVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P62081 Y177 Sugiyama RPS7 HLDKAQQNNVEHKVEtFsGVyKKLTGKDVNFEFPEFQL___
P62258 Y152 Sugiyama YWHAE LAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHPIRLG
P62258 Y49 Sugiyama YWHAE KVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssIEQK
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62312 Y72 Sugiyama LSM6 VNGQLKNKyGDAFIRGNNVLyIstQKRRM____________
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62750 Y144 Sugiyama RPL23A VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P62807 Y41 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKAMG
P62807 Y43 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI QKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKAMGIM
P62826 Y146 Sugiyama RAN ARA24 OK/SW-cl.81 IKDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLAR
P62826 Y147 Sugiyama RAN ARA24 OK/SW-cl.81 KDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLARK
P62899 Y25 Sugiyama RPL31 KKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRA
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62979 Y148 Sugiyama RPS27A UBA80 UBCEP1 AGVFMAsHFDRHyCGKCCLtyCFNKPEDK____________
P63104 Y48 Sugiyama YWHAZ sVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssIEQK
P63220 Y53 Sugiyama RPS21 QMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRLA
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 Y197 Sugiyama YBX1 NSEP1 YB1 APEGQAQQRRPyRRRRFPPyyMRRPYGRRPQysNPPVQGEV
P67809 Y72 Sugiyama YBX1 NSEP1 YB1 KKVIATKVLGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIK
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68104 Y254 Sugiyama EEF1A1 EEF1A EF1A LENG7 CILPPtRPTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKP
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363 S439 Sugiyama TUBA1B SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P68431 Y42 EPSD H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J ATKAARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELL
P83731 Y11 Sugiyama RPL24 __________MKVELCsFsGyKIYPGHGRRYARTDGKVFQF
P98082 Y38 Sugiyama DAB2 DOC2 AAPKAPsKKEKKKGPEKTDEyLLARFKGDGVKYKAKLIGID
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01105 Y146 Sugiyama SET tEFEDIKsGyRIDFyFDENPyFENKVLSKEFHLNEsGDPss
Q01130 Y44 Sugiyama SRSF2 SFRS2 RtsPDtLRRVFEKYGRVGDVyIPRDRYTKESRGFAFVRFHD
Q04917 Y49 Sugiyama YWHAH YWHA1 AVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSIEQK
Q05639 Y254 Sugiyama EEF1A2 EEF1AL STN TILPPTRPTDKPLRLPLQDVyKIGGIGtVPVGRVETGILRP
Q06124 Y304 SIGNOR PTPN11 PTP2C SHPTP2 PFDHTRVVLHDGDPNEPVSDyINANIIMPEFETKCNNSKPK
Q06124 Y327 SIGNOR PTPN11 PTP2C SHPTP2 ANIIMPEFETKCNNSKPKKSyIATQGCLQNTVNDFWRMVFQ
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q07955 Y189 Sugiyama SRSF1 ASF SF2 SF2P33 SFRS1 OK/SW-cl.3 TYAVRKLDNTKFRsHEGEtAyIRVKVDGPRsPsyGRsRsRs
Q13069 Y10 Sugiyama GAGE5 ___________MSWRGRsTyyWPRPRRYVQPPEVIGPMRPE
Q13070 Y10 Sugiyama GAGE6 ___________MSWRGRsTyyWPRPRRYVQPPEVIGPMRPE
Q13310 Y194 Sugiyama PABPC4 APP1 PABP4 KSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELFsQF
Q13546 Y384 PSP RIPK1 RIP RIP1 EHPQEENEPSLQSKLQDEANyHLyGsRMDRQTKQQPRQNVA
Q13561 Y6 Sugiyama DCTN2 DCTN50 _______________MADPKyADLPGIARNEPDVYETSDLP
Q13573 Y176 Sugiyama SNW1 SKIIP SKIP SQKVAAAMPVRAADKLAPAQyIRytPsQQGVAFNsGAKQRV
Q13651 Y446 SIGNOR|iPTMNet|EPSD IL10RA IL10R SPPEPEVPGEEDPAAVAFQGyLRQTRCAEEKATKTGCLEEE
Q13651 Y496 SIGNOR|iPTMNet|EPSD IL10RA IL10R KFGRCLVDEAGLHPPALAKGyLKQDPLEMTLASSGAPTGQW
Q13765 Y120 Sugiyama NACA HSD48 KNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAAA
Q14152 Y697 Sugiyama EIF3A EIF3S10 KIAA0139 LEKEKKELQERLKNQEKKIDyFERAKRLEEIPLIKSAYEEQ
Q14240 Y71 Sugiyama EIF4A2 DDX2B EIF4F yGFEKPsAIQQRAIIPCIKGyDVIAQAQsGtGKTATFAISI
Q14247 Y141 Sugiyama CTTN EMS1 FGGKFGVQMDRVDQsAVGFEyQGKtEKHAsQKDyssGFGGK
Q14247 Y215 Sugiyama CTTN EMS1 FGGKyGIDKDKVDKsAVGFEyQGKtEKHESQKDyVKGFGGK
Q14247 Y334 Sugiyama CTTN EMS1 KDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKtsNIRANF
Q14257 Y311 Sugiyama RCN2 ERC55 NPDLFLtsEAtDyGRQLHDDyFyHDEL______________
Q14765 Y693 ELM STAT4 KHYSSQPCEVSRPTERGDKGyVPSVFIPISTIRSDSTEPHs
Q15293 Y140 Sugiyama RCN1 RCN VAKVWKDYDRDKDDKISWEEyKQAtyGyyLGNPAEFHDssD
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q15424 Y723 Sugiyama SAFB HAP HET SAFB1 EQERRPAVRRPYDLDRRDDAyWPEAKRAALDERYHSDFNRQ
Q15427 Y16 Sugiyama SF3B4 SAP49 _____MAAGPISERNQDAtVyVGGLDEKVSEPLLWELFLQA
Q15527 Y123 Sugiyama SURF2 GRRYQRALCKYEECQKQGVEyVPACLVHRRRRREDQMDGDG
Q15555 Y268 Sugiyama MAPRE2 RP1 NEQVHsLKLALEGVEKERDFyFGKLREIELLCQEHGQENDD
Q15691 Y217 Sugiyama MAPRE1 MQQVNVLKLtVEDLEKERDFyFGKLRNIELICQENEGENDP
Q16719 Y47 Sugiyama KYNU ERVALHLDEEDKLRHFRECFyIPKIQDLPPVDLSLVNKDEN
Q4VXU2 Y291 Sugiyama PABPC1L C20orf119 ERQNELKRRFEQMKQDRLRRyQGVNLyVKNLDDSIDDDKLR
Q4VXU2 Y297 Sugiyama PABPC1L C20orf119 KRRFEQMKQDRLRRyQGVNLyVKNLDDSIDDDKLRKEFSPY
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF3 Y58 Sugiyama HSP90B2P GRP94B GRP94P1 TRAP1 VTFKSILFVPTFVPRGLFDEyGsKKSDYIKLYVRCVFITDD
Q58FF8 Y260 Sugiyama HSP90AB2P HSP90BB VRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVW
Q58FF8 Y261 Sugiyama HSP90AB2P HSP90BB RYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVWK
Q5JTH9 Y1251 Sugiyama RRP12 KIAA0690 AEYKAKKAKGDVKKKGRPDPyAyIPLNRSKLNRRKKMKLQG
Q5JTH9 Y1253 Sugiyama RRP12 KIAA0690 YKAKKAKGDVKKKGRPDPyAyIPLNRSKLNRRKKMKLQGQF
Q5QNW6 Y41 Sugiyama H2BC18 HIST2H2BF KVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
Q5QNW6 Y43 Sugiyama H2BC18 HIST2H2BF QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q5T035 T62 Sugiyama FAM120A2P C9orf129 yPysLSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyER
Q5T035 Y67 Sugiyama FAM120A2P C9orf129 SEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPIN
Q5VTE0 Y254 Sugiyama EEF1A1P5 EEF1AL3 CILPPtRPTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKP
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6ZN18 S206 Sugiyama AEBP2 DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q71U36 S439 Sugiyama TUBA1A TUBA3 SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q86V81 Y250 Sugiyama ALYREF ALY BEF THOC4 AGRNSKQQLsAEELDAQLDAyNARMDts_____________
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8NI22 Y135 Sugiyama MCFD2 SDNSF DELINIIDGVLRDDDKNNDGyIDyAEFAKSLQ_________
Q8TDD1 Y681 Sugiyama DDX54 GPNRGAKRRREEARQRDQEFyIPyRPKDFDSERGLsIsGEG
Q93079 Y41 Sugiyama H2BC9 H2BFJ HIST1H2BH KAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
Q93079 Y43 Sugiyama H2BC9 H2BFJ HIST1H2BH QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q96C90 Y29 Sugiyama PPP1R14B PLCB3N PNG GAALAAPAPGPGsGGPGPRVyFQsPPGAAGEGPGGADDEGP
Q96CT7 Y38 Sugiyama CCDC124 RRAEAKAAADAKKQKELEDAyWKDDDKHVMRKEQRKEEKEK
Q96EB6 Y280 EPSD|PSP SIRT1 SIR2L1 TGAGVSVSCGIPDFRSRDGIyARLAVDFPDLPDPQAMFDIE
Q96EB6 Y301 EPSD|PSP SIRT1 SIR2L1 ARLAVDFPDLPDPQAMFDIEyFRKDPRPFFKFAKEIYPGQF
Q99470 Y187 Sugiyama SDF2 GRPISGQKEVHGMAQPSQNNyWKAMEGIFMKPSELLKAEAH
Q99683 Y718 EPSD|PSP MAP3K5 ASK1 MAPKKK5 MEKK5 RDLSNQVRIAIKEIPERDSRySQPLHEEIALHKHLKHKNIV
Q99733 Y95 Sugiyama NAP1L4 NAP2 VRCAHIEAKFyEEVHDLERKyAALyQPLFDKRREFItGDVE
Q99733 Y99 Sugiyama NAP1L4 NAP2 HIEAKFyEEVHDLERKyAALyQPLFDKRREFItGDVEPtDA
Q99877 Y41 Sugiyama H2BC15 H2BFD HIST1H2BN KAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
Q99877 Y43 Sugiyama H2BC15 H2BFD HIST1H2BN QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q99879 Y41 Sugiyama H2BC14 H2BFE HIST1H2BM KAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
Q99879 Y43 Sugiyama H2BC14 H2BFE HIST1H2BM QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q99880 Y41 Sugiyama H2BC13 H2BFC HIST1H2BL KAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
Q99880 Y43 Sugiyama H2BC13 H2BFC HIST1H2BL QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q9BRL6 Y44 Sugiyama SRSF8 SFRS2B SRP46 RtsPDsLRRVFEKYGRVGDVyIPREPHTKAPRGFAFVRFHD
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9HAP6 S120 Sugiyama LIN7B MALS2 VELI2 UNQ3116/PRO10200 DEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLKRGDQL
Q9HAP6 Y118 Sugiyama LIN7B MALS2 VELI2 UNQ3116/PRO10200 KTDEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLKRGD
Q9HB71 Y165 Sugiyama CACYBP S100A6BP SIP PNAS-107 VKTDTVLILCRKKVENTRWDyLtQVEKECKEKEKPsYDtEt
Q9HCN8 Y81 Sugiyama SDF2L1 UNQ1941/PRO4424 GSGSGQQSVtGVEAsDDANSyWRIRGGSEGGCPRGSPVRCG
Q9NRF2 Y439 GPS6 SH2B1 KIAA1299 SH2B PSQDLLLGPSESNDRLSQGAyGGLSDRPSASISPSSASIAA
Q9NRF2 Y494 GPS6 SH2B1 KIAA1299 SH2B PRIPIEEGPPTGTVHPLSAPyPPLDTPETATGSFLFQGEPE
Q9NUP9 S120 Sugiyama LIN7C MALS3 VELI3 EEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLKRGDQL
Q9NUP9 Y118 Sugiyama LIN7C MALS3 VELI3 KTEEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLKRGD
Q9NYF8 Y219 Sugiyama BCLAF1 BTF KIAA0164 IDEFNKssAtsGDIWPGLsAyDNsPRsPHsPsPIAtPPSQS
Q9NZB2 T413 Sugiyama FAM120A C9orf10 KIAA0183 OSSA yPysLSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyER
Q9NZB2 Y418 Sugiyama FAM120A C9orf10 KIAA0183 OSSA SEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPIN
Q9NZJ5 Y585 SIGNOR|PSP EIF2AK3 PEK PERK yDsVSGEANDSSWNDIKNSGyISRYLTDFEPIQCLGRGGFG
Q9NZJ5 Y619 SIGNOR|PSP EIF2AK3 PEK PERK LGRGGFGVVFEAKNKVDDCNyAIKRIRLPNRELAREKVMRE
Q9NZQ7 Y112 PSP CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1 LSLGNAALQITDVKLQDAGVyRCMISYGGADYKRITVKVNA
Q9UBR2 Y76 Sugiyama CTSZ YLSPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHA
Q9UI15 Y192 Sugiyama TAGLN3 NP25 NVIGLQMGSNKGAsQAGMtGyGMPRQIM_____________
Q9UJU6 Y16 Sugiyama DBNL CMAP SH3P7 PP5423 _____MAANLSRNGPALQEAyVRVVtEKsPtDWALFTyEGN
Q9UMX5 Y65 Sugiyama NENF CIR2 SPUF RLFtEEELARYGGEEEDQPIyLAVKGVVFDVtSGKEFYGRG
Q9Y2T7 Y107 Sugiyama YBX2 CSDA3 MSY2 KPVLAIQVLGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIK
Q9Y3U8 Y53 Sugiyama RPL36 LTKHTKFVRDMIREVCGFAPyERRAMELLKVSKDKRALKFI
Q9Y4H2 Y742 Sugiyama IRS2 ASGGGYKAssPAEssPEDsGyMRMWCGSKLSMEHADGKLLP
Q9Y5X2 Y126 SIGNOR|EPSD|PSP SNX8 VYRRYNDFVVFQEMLLHKFPyRMVPALPPKRMLGADREFIE
Q9Y5X2 Y95 SIGNOR|EPSD|PSP SNX8 DTVQVELIPEKKGLFLKHVEyEVSSQRFKSSVYRRYNDFVV
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.096546e-13 12.149 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.522094e-12 11.124 0 0
Signal Transduction R-HSA-162582 1.757834e-09 8.755 1 0
RAF/MAP kinase cascade R-HSA-5673001 7.347721e-09 8.134 1 1
MAPK1/MAPK3 signaling R-HSA-5684996 1.031923e-08 7.986 1 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.258257e-08 7.139 0 0
Signaling by ERBB2 R-HSA-1227986 6.420912e-08 7.192 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 8.012687e-08 7.096 0 0
Signaling by ALK in cancer R-HSA-9700206 8.012687e-08 7.096 0 0
Signaling by PTK6 R-HSA-8848021 9.216756e-08 7.035 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.216756e-08 7.035 0 0
MAPK family signaling cascades R-HSA-5683057 9.591667e-08 7.018 1 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.212883e-07 6.655 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.227063e-07 6.652 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.203332e-07 6.494 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.560811e-07 6.255 0 0
Long-term potentiation R-HSA-9620244 1.232712e-06 5.909 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.717782e-06 5.765 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.727512e-06 5.763 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.894149e-06 5.538 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.361817e-06 5.078 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.993677e-05 4.700 0 0
Signaling by ERBB4 R-HSA-1236394 3.211666e-05 4.493 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.443726e-05 4.463 0 0
Axon guidance R-HSA-422475 3.809045e-05 4.419 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.765879e-05 4.424 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.737330e-05 4.427 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.129107e-05 4.384 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.713291e-05 4.327 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.713291e-05 4.327 0 0
NrCAM interactions R-HSA-447038 6.368049e-05 4.196 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.855306e-05 4.164 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.360857e-05 4.078 0 0
Nervous system development R-HSA-9675108 8.493369e-05 4.071 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.988138e-05 4.001 0 0
EPH-Ephrin signaling R-HSA-2682334 1.240319e-04 3.906 0 0
Erythropoietin activates STAT5 R-HSA-9027283 1.332506e-04 3.875 0 0
Signaling by VEGF R-HSA-194138 1.430551e-04 3.844 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.971104e-04 3.705 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.395278e-04 3.621 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.494426e-04 3.603 0 0
Signaling by KIT in disease R-HSA-9669938 2.494426e-04 3.603 0 0
Signaling by FGFR in disease R-HSA-1226099 2.707560e-04 3.567 0 0
Growth hormone receptor signaling R-HSA-982772 2.846811e-04 3.546 0 0
Co-stimulation by CD28 R-HSA-389356 3.621055e-04 3.441 0 0
PI3K/AKT activation R-HSA-198203 3.892696e-04 3.410 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.892696e-04 3.410 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.892696e-04 3.410 0 0
Signaling by Leptin R-HSA-2586552 3.892696e-04 3.410 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.618979e-04 3.335 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.824233e-04 3.317 0 0
PECAM1 interactions R-HSA-210990 4.824233e-04 3.317 0 0
mRNA 3'-end processing R-HSA-72187 4.942047e-04 3.306 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.060539e-04 3.296 0 0
Signaling by Interleukins R-HSA-449147 5.704742e-04 3.244 1 0
L1CAM interactions R-HSA-373760 5.294857e-04 3.276 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.052683e-04 3.218 1 0
Post NMDA receptor activation events R-HSA-438064 6.174626e-04 3.209 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.090170e-04 3.149 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.577652e-04 3.067 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.210223e-04 3.036 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 9.210223e-04 3.036 0 0
Regulation of KIT signaling R-HSA-1433559 9.939702e-04 3.003 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.030690e-03 2.987 0 0
Erythropoietin activates RAS R-HSA-9027284 1.159975e-03 2.936 0 0
IGF1R signaling cascade R-HSA-2428924 1.110863e-03 2.954 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.180153e-03 2.928 0 0
GPVI-mediated activation cascade R-HSA-114604 1.226743e-03 2.911 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.353256e-03 2.869 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 1.353256e-03 2.869 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.542109e-03 2.812 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.417793e-03 2.848 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.694570e-03 2.771 0 0
Interleukin-2 family signaling R-HSA-451927 1.694570e-03 2.771 1 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.855193e-03 2.732 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.994879e-03 2.700 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.117883e-03 2.674 1 0
Signaling by SCF-KIT R-HSA-1433557 2.273820e-03 2.643 0 0
Regulation of signaling by CBL R-HSA-912631 2.249092e-03 2.648 0 0
Signaling by NTRKs R-HSA-166520 2.137396e-03 2.670 0 0
IRS activation R-HSA-74713 2.615708e-03 2.582 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.912148e-03 2.536 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.128933e-03 2.505 1 1
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.128933e-03 2.505 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.128933e-03 2.505 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.128933e-03 2.505 0 0
PI3K Cascade R-HSA-109704 3.592496e-03 2.445 0 0
Nef and signal transduction R-HSA-164944 4.264239e-03 2.370 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.497435e-03 2.347 0 0
Interleukin-7 signaling R-HSA-1266695 4.591867e-03 2.338 1 1
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.848746e-03 2.314 0 0
Signaling by FGFR1 R-HSA-5654736 5.072264e-03 2.295 0 0
SOS-mediated signalling R-HSA-112412 5.228077e-03 2.282 0 0
IRS-mediated signalling R-HSA-112399 5.353107e-03 2.271 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.919818e-03 2.228 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.282253e-03 2.202 0 0
Interleukin-21 signaling R-HSA-9020958 7.424773e-03 2.129 1 1
ALK mutants bind TKIs R-HSA-9700645 7.424773e-03 2.129 0 0
Signaling by Erythropoietin R-HSA-9006335 6.408184e-03 2.193 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.408184e-03 2.193 1 1
p75NTR regulates axonogenesis R-HSA-193697 7.424773e-03 2.129 0 0
Signaling by FGFR R-HSA-190236 6.468207e-03 2.189 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.455206e-03 2.128 1 1
Trafficking of AMPA receptors R-HSA-399719 7.455206e-03 2.128 0 0
Insulin receptor signalling cascade R-HSA-74751 7.613967e-03 2.118 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.124469e-03 2.090 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.597633e-03 2.066 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.597633e-03 2.066 0 0
Signal attenuation R-HSA-74749 8.653675e-03 2.063 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 1.136293e-02 1.945 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 1.136293e-02 1.945 0 0
mRNA Splicing R-HSA-72172 1.050506e-02 1.979 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.188229e-02 1.925 0 0
ChREBP activates metabolic gene expression R-HSA-163765 9.967028e-03 2.001 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.253026e-02 1.902 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.261410e-02 1.899 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.439495e-02 1.842 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.439495e-02 1.842 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.439495e-02 1.842 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.519469e-02 1.818 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.579543e-02 1.801 0 0
Malate-aspartate shuttle R-HSA-9856872 1.602741e-02 1.795 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.773513e-02 1.751 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.788832e-02 1.747 0 0
Netrin-1 signaling R-HSA-373752 1.845079e-02 1.734 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.951634e-02 1.710 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 2.329239e-02 1.633 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.035026e-02 1.691 0 0
FCGR activation R-HSA-2029481 2.483816e-02 1.605 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.133885e-02 1.671 0 0
Inhibition of PKR R-HSA-169131 2.101563e-02 1.677 0 0
Signaling by Hippo R-HSA-2028269 2.329239e-02 1.633 0 0
Signaling by Insulin receptor R-HSA-74752 2.407975e-02 1.618 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.136933e-02 1.670 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.136933e-02 1.670 0 0
FGFR1 ligand binding and activation R-HSA-190242 2.528387e-02 1.597 0 0
Developmental Biology R-HSA-1266738 2.652934e-02 1.576 0 0
Immune System R-HSA-168256 2.665967e-02 1.574 1 0
Neurexins and neuroligins R-HSA-6794361 2.667081e-02 1.574 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.688340e-02 1.571 0 0
Parasite infection R-HSA-9664407 2.688340e-02 1.571 0 0
Leishmania phagocytosis R-HSA-9664417 2.688340e-02 1.571 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.884575e-02 1.540 0 0
Signal transduction by L1 R-HSA-445144 2.946550e-02 1.531 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.135819e-02 1.504 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.135819e-02 1.504 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.135819e-02 1.504 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.140179e-02 1.503 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 3.621084e-02 1.441 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.854357e-02 1.414 0 0
Interleukin-20 family signaling R-HSA-8854691 3.857921e-02 1.414 1 1
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.857921e-02 1.414 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.926557e-02 1.406 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 4.159212e-02 1.381 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 4.159212e-02 1.381 0 0
MET activates STAT3 R-HSA-8875791 5.171856e-02 1.286 0 0
Axonal growth stimulation R-HSA-209563 5.171856e-02 1.286 0 0
Signalling to STAT3 R-HSA-198745 5.171856e-02 1.286 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 4.100505e-02 1.387 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 4.348688e-02 1.362 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.394583e-02 1.268 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.097224e-02 1.388 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.125413e-02 1.290 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.394583e-02 1.268 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.159212e-02 1.381 0 0
Semaphorin interactions R-HSA-373755 4.066459e-02 1.391 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.348688e-02 1.362 0 0
Myogenesis R-HSA-525793 4.602328e-02 1.337 0 0
Disease R-HSA-1643685 5.377910e-02 1.269 1 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.100505e-02 1.387 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.602328e-02 1.337 0 0
EGFR downregulation R-HSA-182971 5.947502e-02 1.226 0 0
Aspartate and asparagine metabolism R-HSA-8963693 5.947502e-02 1.226 0 0
Downstream signal transduction R-HSA-186763 5.947502e-02 1.226 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 6.173862e-02 1.209 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 6.173862e-02 1.209 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 6.173862e-02 1.209 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 6.173862e-02 1.209 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 6.173862e-02 1.209 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.230990e-02 1.205 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 6.447545e-02 1.191 0 0
Interferon Signaling R-HSA-913531 6.781005e-02 1.169 1 0
Effects of PIP2 hydrolysis R-HSA-114508 6.811382e-02 1.167 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.811382e-02 1.167 0 0
PKR-mediated signaling R-HSA-9833482 6.815196e-02 1.167 0 0
Signaling by FGFR2 R-HSA-5654738 6.815196e-02 1.167 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.108037e-02 1.148 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.108037e-02 1.148 0 0
NTRK2 activates RAC1 R-HSA-9032759 7.165341e-02 1.145 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 7.165341e-02 1.145 0 0
PTK6 Activates STAT3 R-HSA-8849474 7.165341e-02 1.145 0 0
Reelin signalling pathway R-HSA-8866376 7.165341e-02 1.145 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 7.165341e-02 1.145 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 8.146404e-02 1.089 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 8.146404e-02 1.089 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 8.146404e-02 1.089 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 8.146404e-02 1.089 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 9.117159e-02 1.040 0 0
Amplification of signal from the kinetochores R-HSA-141424 7.943069e-02 1.100 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 7.943069e-02 1.100 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.408835e-02 1.130 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.713658e-02 1.113 0 0
Signaling by MST1 R-HSA-8852405 8.146404e-02 1.089 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.651104e-02 1.063 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.146404e-02 1.089 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 8.146404e-02 1.089 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 8.146404e-02 1.089 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.970868e-02 1.047 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.970868e-02 1.047 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.007771e-01 0.997 0 0
Signaling by ALK R-HSA-201556 8.651104e-02 1.063 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 8.146404e-02 1.089 0 0
VLDL clearance R-HSA-8964046 1.007771e-01 0.997 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 9.117159e-02 1.040 0 0
Signaling by FGFR4 R-HSA-5654743 1.028342e-01 0.988 0 0
Signaling by FGFR3 R-HSA-5654741 1.095834e-01 0.960 0 0
VEGF ligand-receptor interactions R-HSA-194313 8.146404e-02 1.089 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 8.146404e-02 1.089 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.538870e-02 1.123 0 0
Glycosphingolipid transport R-HSA-9845576 7.713658e-02 1.113 0 0
RUNX2 regulates bone development R-HSA-8941326 7.713658e-02 1.113 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.022386e-02 1.096 0 0
Interleukin-12 family signaling R-HSA-447115 8.336020e-02 1.079 1 0
Transmission across Chemical Synapses R-HSA-112315 7.466505e-02 1.127 0 0
Parasitic Infection Pathways R-HSA-9824443 1.030514e-01 0.987 0 0
Leishmania infection R-HSA-9658195 1.030514e-01 0.987 0 0
Heme biosynthesis R-HSA-189451 9.620659e-02 1.017 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.282655e-02 1.082 1 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.061941e-01 0.974 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 1.102818e-01 0.957 0 0
Type I hemidesmosome assembly R-HSA-446107 1.102818e-01 0.957 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 1.102818e-01 0.957 0 0
FGFR1b ligand binding and activation R-HSA-190370 1.102818e-01 0.957 0 0
Interleukin-23 signaling R-HSA-9020933 1.102818e-01 0.957 0 0
Interleukin-9 signaling R-HSA-8985947 1.102818e-01 0.957 1 1
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 1.102818e-01 0.957 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.119683e-01 0.951 1 0
Death Receptor Signaling R-HSA-73887 1.119683e-01 0.951 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.382005e-01 0.859 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.382005e-01 0.859 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.382005e-01 0.859 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.382005e-01 0.859 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.473118e-01 0.832 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.563273e-01 0.806 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.563273e-01 0.806 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.563273e-01 0.806 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.563273e-01 0.806 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.563273e-01 0.806 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.740751e-01 0.759 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.828093e-01 0.738 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.828093e-01 0.738 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.828093e-01 0.738 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.828093e-01 0.738 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.914516e-01 0.718 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.084647e-01 0.681 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.251218e-01 0.648 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.084647e-01 0.681 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.084647e-01 0.681 0 0
Ephrin signaling R-HSA-3928664 2.168373e-01 0.664 0 0
Signaling by EGFR R-HSA-177929 1.485336e-01 0.828 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.168373e-01 0.664 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.652481e-01 0.782 0 0
GAB1 signalosome R-HSA-180292 2.168373e-01 0.664 0 0
Interferon alpha/beta signaling R-HSA-909733 1.586614e-01 0.800 1 1
Calcineurin activates NFAT R-HSA-2025928 1.196865e-01 0.922 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.563273e-01 0.806 0 0
FGFR1c ligand binding and activation R-HSA-190373 1.652481e-01 0.782 0 0
DCC mediated attractive signaling R-HSA-418885 1.828093e-01 0.738 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.876910e-01 0.727 1 1
Processing of SMDT1 R-HSA-8949664 1.652481e-01 0.782 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.153229e-01 0.938 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.000031e-01 0.699 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.251218e-01 0.648 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.289924e-01 0.889 0 0
Signaling by APC mutants R-HSA-4839744 1.382005e-01 0.859 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.473118e-01 0.832 0 0
Signaling by AXIN mutants R-HSA-4839735 1.473118e-01 0.832 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.563273e-01 0.806 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.828093e-01 0.738 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.251218e-01 0.648 0 0
Degradation of CDH1 R-HSA-9766229 1.234147e-01 0.909 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 2.084647e-01 0.681 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.708030e-01 0.768 0 0
Smooth Muscle Contraction R-HSA-445355 1.376400e-01 0.861 0 0
Mitotic Prometaphase R-HSA-68877 1.898187e-01 0.722 0 0
Signaling by TGFB family members R-HSA-9006936 1.225751e-01 0.912 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.740751e-01 0.759 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.251218e-01 0.648 0 0
Regulation of CDH1 Function R-HSA-9764561 1.522032e-01 0.818 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.740881e-01 0.759 0 0
Signaling by LTK R-HSA-9842663 1.563273e-01 0.806 0 0
Interleukin-6 signaling R-HSA-1059683 1.652481e-01 0.782 1 1
Signaling by Activin R-HSA-1502540 1.828093e-01 0.738 0 0
Interleukin-15 signaling R-HSA-8983432 1.563273e-01 0.806 1 1
Diseases associated with surfactant metabolism R-HSA-5687613 1.563273e-01 0.806 0 0
Interleukin-27 signaling R-HSA-9020956 1.289924e-01 0.889 1 1
Role of second messengers in netrin-1 signaling R-HSA-418890 1.563273e-01 0.806 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.363911e-01 0.865 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.089749e-01 0.680 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.115028e-01 0.675 0 0
G alpha (q) signalling events R-HSA-416476 1.859145e-01 0.731 0 0
LGI-ADAM interactions R-HSA-5682910 1.382005e-01 0.859 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 1.828093e-01 0.738 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.084647e-01 0.681 0 0
Metabolism of RNA R-HSA-8953854 2.005709e-01 0.698 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.206021e-01 0.656 1 1
Cellular response to mitochondrial stress R-HSA-9840373 1.196865e-01 0.922 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.473118e-01 0.832 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.084647e-01 0.681 0 0
Iron uptake and transport R-HSA-917937 2.206021e-01 0.656 0 0
Neuronal System R-HSA-112316 1.511133e-01 0.821 0 0
RSV-host interactions R-HSA-9833110 1.268685e-01 0.897 1 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.196865e-01 0.922 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.828093e-01 0.738 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.828093e-01 0.738 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.828093e-01 0.738 0 0
Methionine salvage pathway R-HSA-1237112 2.251218e-01 0.648 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.130639e-01 0.947 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.485336e-01 0.828 0 0
Cell-Cell communication R-HSA-1500931 1.494419e-01 0.826 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.225821e-01 0.653 0 0
Other interleukin signaling R-HSA-449836 2.251218e-01 0.648 1 1
Interleukin-35 Signalling R-HSA-8984722 1.563273e-01 0.806 1 1
AKT phosphorylates targets in the cytosol R-HSA-198323 1.563273e-01 0.806 0 0
Platelet sensitization by LDL R-HSA-432142 2.168373e-01 0.664 0 0
Interleukin-2 signaling R-HSA-9020558 1.382005e-01 0.859 1 1
C-type lectin receptors (CLRs) R-HSA-5621481 1.450064e-01 0.839 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.196865e-01 0.922 0 0
Signal regulatory protein family interactions R-HSA-391160 1.740751e-01 0.759 0 0
Deubiquitination R-HSA-5688426 1.699916e-01 0.770 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.168373e-01 0.664 0 0
Dectin-2 family R-HSA-5621480 1.522032e-01 0.818 0 0
NGF-stimulated transcription R-HSA-9031628 1.199176e-01 0.921 0 0
Leishmania parasite growth and survival R-HSA-9664433 1.488932e-01 0.827 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 1.488932e-01 0.827 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.168373e-01 0.664 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.236457e-01 0.650 0 0
Signaling by PDGF R-HSA-186797 1.708030e-01 0.768 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.089749e-01 0.680 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 1.485336e-01 0.828 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 1.633157e-01 0.787 0 0
Dissolution of Fibrin Clot R-HSA-75205 1.382005e-01 0.859 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.745682e-01 0.758 0 0
Metabolism of porphyrins R-HSA-189445 2.051135e-01 0.688 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.340499e-01 0.873 0 0
Apoptotic execution phase R-HSA-75153 1.130010e-01 0.947 0 0
Cellular response to chemical stress R-HSA-9711123 1.931622e-01 0.714 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.821378e-01 0.740 0 0
Interleukin-12 signaling R-HSA-9020591 2.244902e-01 0.649 1 1
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.283836e-01 0.641 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.309215e-01 0.637 0 0
Interleukin-10 signaling R-HSA-6783783 2.322817e-01 0.634 1 1
G alpha (12/13) signalling events R-HSA-416482 2.322817e-01 0.634 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 2.333192e-01 0.632 0 0
Formation of definitive endoderm R-HSA-9823730 2.333192e-01 0.632 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.333192e-01 0.632 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.333192e-01 0.632 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.333192e-01 0.632 0 0
Nephrin family interactions R-HSA-373753 2.333192e-01 0.632 0 0
Signaling by NODAL R-HSA-1181150 2.333192e-01 0.632 0 0
Sensory processing of sound R-HSA-9659379 2.361841e-01 0.627 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 2.361841e-01 0.627 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.365134e-01 0.626 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.400901e-01 0.620 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.414304e-01 0.617 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.414304e-01 0.617 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.449454e-01 0.611 0 0
Neutrophil degranulation R-HSA-6798695 2.469114e-01 0.607 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.494563e-01 0.603 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.494563e-01 0.603 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.494563e-01 0.603 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.494563e-01 0.603 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.573977e-01 0.589 1 1
FGFR2 alternative splicing R-HSA-6803529 2.573977e-01 0.589 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.573977e-01 0.589 0 0
LDL clearance R-HSA-8964038 2.573977e-01 0.589 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.652557e-01 0.576 1 1
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.652557e-01 0.576 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.652557e-01 0.576 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.652557e-01 0.576 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.652557e-01 0.576 0 0
Syndecan interactions R-HSA-3000170 2.652557e-01 0.576 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.652557e-01 0.576 0 0
Sulfur amino acid metabolism R-HSA-1614635 2.674937e-01 0.573 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.674937e-01 0.573 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.730309e-01 0.564 0 0
Interleukin-6 family signaling R-HSA-6783589 2.730309e-01 0.564 1 0
Sema4D in semaphorin signaling R-HSA-400685 2.807243e-01 0.552 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 2.807243e-01 0.552 0 0
TGFBR3 expression R-HSA-9839394 2.807243e-01 0.552 0 0
Laminin interactions R-HSA-3000157 2.807243e-01 0.552 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.870737e-01 0.542 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.877122e-01 0.541 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.883368e-01 0.540 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 2.883368e-01 0.540 0 0
TRP channels R-HSA-3295583 2.883368e-01 0.540 0 0
Urea cycle R-HSA-70635 2.883368e-01 0.540 0 0
IRE1alpha activates chaperones R-HSA-381070 2.909847e-01 0.536 0 0
ESR-mediated signaling R-HSA-8939211 2.918485e-01 0.535 0 0
Regulation of TP53 Activity R-HSA-5633007 2.934684e-01 0.532 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.958692e-01 0.529 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.958692e-01 0.529 0 0
Cristae formation R-HSA-8949613 2.958692e-01 0.529 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.958692e-01 0.529 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.958692e-01 0.529 0 0
Signaling by BMP R-HSA-201451 2.958692e-01 0.529 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.958692e-01 0.529 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.958692e-01 0.529 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 2.987987e-01 0.525 0 0
Apoptosis R-HSA-109581 2.992326e-01 0.524 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.033223e-01 0.518 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.033223e-01 0.518 0 0
HIV elongation arrest and recovery R-HSA-167287 3.033223e-01 0.518 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.033223e-01 0.518 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.033223e-01 0.518 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.033223e-01 0.518 0 0
Separation of Sister Chromatids R-HSA-2467813 3.050032e-01 0.516 0 0
mRNA Capping R-HSA-72086 3.106970e-01 0.508 0 0
Platelet calcium homeostasis R-HSA-418360 3.106970e-01 0.508 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 3.143837e-01 0.503 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.143837e-01 0.503 0 0
DAP12 signaling R-HSA-2424491 3.179941e-01 0.498 0 0
Interleukin-37 signaling R-HSA-9008059 3.179941e-01 0.498 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.182690e-01 0.497 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.252144e-01 0.488 0 0
Cargo concentration in the ER R-HSA-5694530 3.252144e-01 0.488 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 3.252144e-01 0.488 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.323587e-01 0.478 0 0
Signaling by WNT in cancer R-HSA-4791275 3.323587e-01 0.478 0 0
Ub-specific processing proteases R-HSA-5689880 3.339046e-01 0.476 0 0
PI Metabolism R-HSA-1483255 3.376129e-01 0.472 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.376129e-01 0.472 0 0
Integrin signaling R-HSA-354192 3.394277e-01 0.469 0 0
Cardiogenesis R-HSA-9733709 3.394277e-01 0.469 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.394277e-01 0.469 0 0
G-protein beta:gamma signalling R-HSA-397795 3.394277e-01 0.469 0 0
Cell Cycle Checkpoints R-HSA-69620 3.419430e-01 0.466 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.453062e-01 0.462 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.453062e-01 0.462 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.464224e-01 0.460 0 0
Glutamate and glutamine metabolism R-HSA-8964539 3.464224e-01 0.460 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 3.464224e-01 0.460 0 0
Hemostasis R-HSA-109582 3.517642e-01 0.454 0 0
RAF activation R-HSA-5673000 3.533434e-01 0.452 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.567915e-01 0.448 0 0
Platelet homeostasis R-HSA-418346 3.567915e-01 0.448 0 0
PERK regulates gene expression R-HSA-381042 3.601916e-01 0.443 0 0
Oncogene Induced Senescence R-HSA-2559585 3.601916e-01 0.443 0 0
Calmodulin induced events R-HSA-111933 3.669676e-01 0.435 0 0
CaM pathway R-HSA-111997 3.669676e-01 0.435 0 0
FGFR2 mutant receptor activation R-HSA-1839126 3.669676e-01 0.435 0 0
RET signaling R-HSA-8853659 3.669676e-01 0.435 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.736724e-01 0.428 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 3.736724e-01 0.428 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.868707e-01 0.412 0 0
Stabilization of p53 R-HSA-69541 3.868707e-01 0.412 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.868707e-01 0.412 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.868707e-01 0.412 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.868707e-01 0.412 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.868707e-01 0.412 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.870487e-01 0.412 0 0
Cell junction organization R-HSA-446728 3.899080e-01 0.409 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.933658e-01 0.405 0 0
HIV Transcription Elongation R-HSA-167169 3.933658e-01 0.405 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.933658e-01 0.405 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.933658e-01 0.405 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.933658e-01 0.405 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.933658e-01 0.405 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 3.982382e-01 0.400 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 3.982382e-01 0.400 0 0
FLT3 Signaling R-HSA-9607240 3.997925e-01 0.398 0 0
Mitochondrial biogenesis R-HSA-1592230 4.056457e-01 0.392 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.061515e-01 0.391 0 0
HIV Transcription Initiation R-HSA-167161 4.061515e-01 0.391 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.061515e-01 0.391 0 0
MAP2K and MAPK activation R-HSA-5674135 4.061515e-01 0.391 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.061515e-01 0.391 0 0
Intra-Golgi traffic R-HSA-6811438 4.061515e-01 0.391 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.061515e-01 0.391 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.061515e-01 0.391 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.124436e-01 0.385 0 0
Ca-dependent events R-HSA-111996 4.124436e-01 0.385 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 4.124436e-01 0.385 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.130096e-01 0.384 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.186693e-01 0.378 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.186693e-01 0.378 0 0
Cellular response to heat stress R-HSA-3371556 4.203286e-01 0.376 0 0
Cellular responses to stress R-HSA-2262752 4.247974e-01 0.372 0 0
DAP12 interactions R-HSA-2172127 4.248295e-01 0.372 0 0
Surfactant metabolism R-HSA-5683826 4.248295e-01 0.372 0 0
Cyclin D associated events in G1 R-HSA-69231 4.248295e-01 0.372 0 0
G1 Phase R-HSA-69236 4.248295e-01 0.372 0 0
Programmed Cell Death R-HSA-5357801 4.282104e-01 0.368 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.309248e-01 0.366 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.309248e-01 0.366 0 0
DAG and IP3 signaling R-HSA-1489509 4.309248e-01 0.366 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 4.309248e-01 0.366 0 0
Host Interactions of HIV factors R-HSA-162909 4.312197e-01 0.365 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.369558e-01 0.360 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.369558e-01 0.360 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.369558e-01 0.360 0 0
Signaling by RAS mutants R-HSA-6802949 4.369558e-01 0.360 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.369558e-01 0.360 0 0
Signaling by TGFBR3 R-HSA-9839373 4.369558e-01 0.360 0 0
Recycling pathway of L1 R-HSA-437239 4.429233e-01 0.354 0 0
Muscle contraction R-HSA-397014 4.476948e-01 0.349 0 0
Metal ion SLC transporters R-HSA-425410 4.488279e-01 0.348 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.546703e-01 0.342 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.546703e-01 0.342 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 4.546703e-01 0.342 0 0
RNA Polymerase II Transcription R-HSA-73857 4.586221e-01 0.339 0 0
Mitotic Anaphase R-HSA-68882 4.587114e-01 0.338 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.604511e-01 0.337 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.604511e-01 0.337 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 4.604511e-01 0.337 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.614513e-01 0.336 0 0
Adipogenesis R-HSA-9843745 4.632266e-01 0.334 0 0
Adherens junctions interactions R-HSA-418990 4.641853e-01 0.333 0 0
Innate Immune System R-HSA-168249 4.666316e-01 0.331 0 0
Cellular responses to stimuli R-HSA-8953897 4.692371e-01 0.329 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.718307e-01 0.326 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.718307e-01 0.326 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.774306e-01 0.321 0 0
Translation initiation complex formation R-HSA-72649 4.829715e-01 0.316 0 0
Integration of energy metabolism R-HSA-163685 4.839742e-01 0.315 0 0
HDACs deacetylate histones R-HSA-3214815 4.884541e-01 0.311 0 0
G alpha (z) signalling events R-HSA-418597 4.884541e-01 0.311 0 0
Paracetamol ADME R-HSA-9753281 4.884541e-01 0.311 0 0
Signaling by NOTCH3 R-HSA-9012852 4.884541e-01 0.311 0 0
HIV Infection R-HSA-162906 4.885129e-01 0.311 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.938788e-01 0.306 0 0
NRAGE signals death through JNK R-HSA-193648 4.938788e-01 0.306 0 0
TNF signaling R-HSA-75893 4.938788e-01 0.306 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.938788e-01 0.306 0 0
Synthesis of PA R-HSA-1483166 4.992463e-01 0.302 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.045572e-01 0.297 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.075476e-01 0.295 1 1
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 5.098121e-01 0.293 0 0
FCERI mediated NF-kB activation R-HSA-2871837 5.141541e-01 0.289 0 0
Cell surface interactions at the vascular wall R-HSA-202733 5.149075e-01 0.288 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.150117e-01 0.288 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.150117e-01 0.288 0 0
Glutathione conjugation R-HSA-156590 5.150117e-01 0.288 0 0
tRNA Aminoacylation R-HSA-379724 5.150117e-01 0.288 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.201563e-01 0.284 0 0
PLC beta mediated events R-HSA-112043 5.201563e-01 0.284 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.201563e-01 0.284 0 0
tRNA processing in the nucleus R-HSA-6784531 5.252468e-01 0.280 0 0
Mitochondrial protein import R-HSA-1268020 5.252468e-01 0.280 0 0
Heme signaling R-HSA-9707616 5.252468e-01 0.280 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.252468e-01 0.280 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.302835e-01 0.275 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.302835e-01 0.275 0 0
Gastrulation R-HSA-9758941 5.304145e-01 0.275 0 0
Potential therapeutics for SARS R-HSA-9679191 5.336222e-01 0.273 1 1
CD22 mediated BCR regulation R-HSA-5690714 5.352671e-01 0.271 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.368151e-01 0.270 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.401981e-01 0.267 0 0
Protein localization R-HSA-9609507 5.431560e-01 0.265 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.450772e-01 0.264 0 0
G-protein mediated events R-HSA-112040 5.499047e-01 0.260 0 0
Cell-cell junction organization R-HSA-421270 5.506157e-01 0.259 0 0
Transcription of the HIV genome R-HSA-167172 5.546813e-01 0.256 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.546813e-01 0.256 0 0
COPII-mediated vesicle transport R-HSA-204005 5.640839e-01 0.249 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.640839e-01 0.249 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.640839e-01 0.249 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.640839e-01 0.249 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 5.640839e-01 0.249 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.687109e-01 0.245 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.687109e-01 0.245 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.732890e-01 0.242 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.778189e-01 0.238 0 0
Developmental Cell Lineages R-HSA-9734767 5.799717e-01 0.237 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.823009e-01 0.235 0 0
Adaptive Immune System R-HSA-1280218 5.842297e-01 0.233 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.867357e-01 0.232 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.911236e-01 0.228 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.997610e-01 0.222 0 0
RNA Polymerase I Transcription R-HSA-73864 5.997610e-01 0.222 0 0
PCP/CE pathway R-HSA-4086400 5.997610e-01 0.222 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.060677e-01 0.217 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.060677e-01 0.217 0 0
Signaling by MET R-HSA-6806834 6.082169e-01 0.216 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.117071e-01 0.213 0 0
Amyloid fiber formation R-HSA-977225 6.123781e-01 0.213 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.123781e-01 0.213 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.164953e-01 0.210 0 0
Respiratory electron transport R-HSA-611105 6.200512e-01 0.208 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.205690e-01 0.207 0 0
M Phase R-HSA-68886 6.220874e-01 0.206 0 0
Influenza Infection R-HSA-168255 6.228019e-01 0.206 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.239302e-01 0.205 0 0
Cellular Senescence R-HSA-2559583 6.255374e-01 0.204 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.285878e-01 0.202 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.325338e-01 0.199 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.364381e-01 0.196 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.364381e-01 0.196 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.403012e-01 0.194 0 0
Peptide ligand-binding receptors R-HSA-375276 6.416298e-01 0.193 0 0
Phospholipid metabolism R-HSA-1483257 6.521575e-01 0.186 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.626375e-01 0.179 0 0
Protein folding R-HSA-391251 6.626375e-01 0.179 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.626375e-01 0.179 0 0
HCMV Early Events R-HSA-9609690 6.672402e-01 0.176 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.672402e-01 0.176 0 0
Mitochondrial protein degradation R-HSA-9837999 6.697721e-01 0.174 0 0
Collagen formation R-HSA-1474290 6.697721e-01 0.174 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.732829e-01 0.172 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.767567e-01 0.170 0 0
Sphingolipid metabolism R-HSA-428157 6.794855e-01 0.168 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.801937e-01 0.167 0 0
FOXO-mediated transcription R-HSA-9614085 6.902883e-01 0.161 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.968413e-01 0.157 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.000660e-01 0.155 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.000660e-01 0.155 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.021360e-01 0.154 0 0
Opioid Signalling R-HSA-111885 7.064134e-01 0.151 0 0
Signaling by GPCR R-HSA-372790 7.196982e-01 0.143 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.217036e-01 0.142 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.217036e-01 0.142 0 0
Stimuli-sensing channels R-HSA-2672351 7.217036e-01 0.142 0 0
Gene expression (Transcription) R-HSA-74160 7.233831e-01 0.141 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.333636e-01 0.135 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.333636e-01 0.135 0 0
FCERI mediated MAPK activation R-HSA-2871796 7.333636e-01 0.135 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.373582e-01 0.132 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 7.397726e-01 0.131 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.414211e-01 0.130 1 0
Transport of small molecules R-HSA-382551 7.427934e-01 0.129 0 0
GPCR downstream signalling R-HSA-388396 7.443121e-01 0.128 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.499491e-01 0.125 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.499491e-01 0.125 0 0
Cell Cycle, Mitotic R-HSA-69278 7.500899e-01 0.125 0 0
Rab regulation of trafficking R-HSA-9007101 7.526118e-01 0.123 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 7.611820e-01 0.119 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 7.680065e-01 0.115 0 0
Formation of the cornified envelope R-HSA-6809371 7.704781e-01 0.113 0 0
Platelet degranulation R-HSA-114608 7.801051e-01 0.108 0 0
HCMV Infection R-HSA-9609646 7.826813e-01 0.106 0 0
Viral Infection Pathways R-HSA-9824446 7.836781e-01 0.106 1 0
Cell Cycle R-HSA-1640170 7.902797e-01 0.102 0 0
Sensory perception of taste R-HSA-9717189 7.915763e-01 0.102 0 0
Cardiac conduction R-HSA-5576891 7.915763e-01 0.102 0 0
Generic Transcription Pathway R-HSA-212436 7.923410e-01 0.101 0 0
Circadian clock R-HSA-9909396 7.937981e-01 0.100 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.959964e-01 0.099 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.045589e-01 0.094 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.050606e-01 0.094 0 0
PTEN Regulation R-HSA-6807070 8.107454e-01 0.091 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.186923e-01 0.087 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 8.193862e-01 0.087 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.263073e-01 0.083 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.281609e-01 0.082 0 0
G alpha (i) signalling events R-HSA-418594 8.351612e-01 0.078 0 0
Arachidonate metabolism R-HSA-2142753 8.371377e-01 0.077 0 0
Interleukin-1 family signaling R-HSA-446652 8.371377e-01 0.077 0 0
Membrane Trafficking R-HSA-199991 8.420087e-01 0.075 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.422984e-01 0.075 0 0
HIV Life Cycle R-HSA-162587 8.456482e-01 0.073 0 0
HCMV Late Events R-HSA-9610379 8.456482e-01 0.073 0 0
Interferon gamma signaling R-HSA-877300 8.489273e-01 0.071 1 1
Signaling by WNT R-HSA-195721 8.532337e-01 0.069 0 0
Translation R-HSA-72766 8.591759e-01 0.066 0 0
SLC transporter disorders R-HSA-5619102 8.613653e-01 0.065 0 0
SARS-CoV Infections R-HSA-9679506 8.636413e-01 0.064 1 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.671970e-01 0.062 0 0
tRNA processing R-HSA-72306 8.671970e-01 0.062 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.700207e-01 0.060 0 0
Infectious disease R-HSA-5663205 8.801583e-01 0.055 1 0
Metabolism of steroids R-HSA-8957322 8.821174e-01 0.054 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.845172e-01 0.053 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.905637e-01 0.050 0 0
Ion channel transport R-HSA-983712 8.917347e-01 0.050 0 0
Cilium Assembly R-HSA-5617833 8.928932e-01 0.049 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.038216e-01 0.044 0 0
Co-inhibition by PD-1 R-HSA-389948 9.038216e-01 0.044 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.048736e-01 0.043 1 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.058704e-01 0.043 0 0
Signaling by ROBO receptors R-HSA-376176 9.068785e-01 0.042 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.068785e-01 0.042 0 0
Keratinization R-HSA-6805567 9.108046e-01 0.041 0 0
Drug ADME R-HSA-9748784 9.216225e-01 0.035 0 0
Neddylation R-HSA-8951664 9.241165e-01 0.034 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.303883e-01 0.031 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.311351e-01 0.031 0 0
rRNA processing R-HSA-72312 9.326049e-01 0.030 0 0
Chromatin modifying enzymes R-HSA-3247509 9.340435e-01 0.030 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.375079e-01 0.028 0 0
Signaling by NOTCH R-HSA-157118 9.381788e-01 0.028 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.426785e-01 0.026 0 0
Vesicle-mediated transport R-HSA-5653656 9.426799e-01 0.026 0 0
Fatty acid metabolism R-HSA-8978868 9.433835e-01 0.025 0 0
Chromatin organization R-HSA-4839726 9.439032e-01 0.025 0 0
GPCR ligand binding R-HSA-500792 9.589747e-01 0.018 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.676434e-01 0.014 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.748203e-01 0.011 0 0
Extracellular matrix organization R-HSA-1474244 9.769143e-01 0.010 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.838713e-01 0.007 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.888624e-01 0.005 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.915213e-01 0.004 0 0
Diseases of metabolism R-HSA-5668914 9.919719e-01 0.004 0 0
Metabolism of lipids R-HSA-556833 9.925046e-01 0.003 0 0
Metabolism of proteins R-HSA-392499 9.949142e-01 0.002 0 0
Biological oxidations R-HSA-211859 9.971958e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.978341e-01 0.001 0 0
Sensory Perception R-HSA-9709957 9.998909e-01 0.000 0 0
Metabolism R-HSA-1430728 9.999998e-01 0.000 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.000000e+00 0.000 1 1
RAF-independent MAPK1/3 activation R-HSA-112409 1.000000e+00 0.000 1 0
MAPK1 (ERK2) activation R-HSA-112411 1.000000e+00 0.000 1 1
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 1.000000e+00 0.000 1 1
Regulation of IFNG signaling R-HSA-877312 1.000000e+00 0.000 1 1
IFNG signaling activates MAPKs R-HSA-9732724 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
G2/M DNA damage checkpoint R-HSA-69473 1.110223e-16 15.955 0 0
G2/M Checkpoints R-HSA-69481 1.332268e-14 13.875 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.964295e-14 13.528 0 0
Packaging Of Telomere Ends R-HSA-171306 8.248957e-14 13.084 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.248957e-14 13.084 0 0
DNA methylation R-HSA-5334118 1.547651e-13 12.810 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.725908e-13 12.429 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.914957e-13 12.308 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.372192e-13 12.077 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.372192e-13 12.077 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.389333e-12 11.857 0 0
Cell Cycle Checkpoints R-HSA-69620 1.490141e-12 11.827 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.773581e-12 11.751 0 0
Cleavage of the damaged purine R-HSA-110331 1.773581e-12 11.751 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.981526e-12 11.703 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.981526e-12 11.703 0 0
Depurination R-HSA-73927 2.251310e-12 11.648 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.685296e-12 11.571 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.569589e-12 11.447 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.569589e-12 11.447 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.460765e-12 11.351 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.460765e-12 11.351 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.868506e-12 11.163 0 0
Depyrimidination R-HSA-73928 6.868506e-12 11.163 0 0
Signal Transduction R-HSA-162582 7.990941e-12 11.097 1 0
Defective pyroptosis R-HSA-9710421 8.466006e-12 11.072 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.303558e-12 11.031 0 0
Nucleosome assembly R-HSA-774815 1.270228e-11 10.896 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.270228e-11 10.896 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.244793e-11 10.905 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.294642e-11 10.888 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.546663e-11 10.811 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.267619e-11 10.644 0 0
Diseases of programmed cell death R-HSA-9645723 3.613321e-11 10.442 0 0
Meiotic recombination R-HSA-912446 3.922207e-11 10.406 0 0
Cell junction organization R-HSA-446728 4.207745e-11 10.376 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.677803e-11 10.330 0 0
Cell-Cell communication R-HSA-1500931 4.844691e-11 10.315 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.110135e-11 10.292 0 0
Meiotic synapsis R-HSA-1221632 5.561918e-11 10.255 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.891176e-11 10.230 0 0
Adherens junctions interactions R-HSA-418990 6.355649e-11 10.197 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 6.593626e-11 10.181 0 0
HDACs deacetylate histones R-HSA-3214815 7.794365e-11 10.108 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.266703e-10 9.897 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.481609e-10 9.829 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.728733e-10 9.762 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.219128e-10 9.654 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.336935e-10 9.631 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.159053e-10 9.381 0 0
Gene Silencing by RNA R-HSA-211000 4.253028e-10 9.371 0 0
DNA Double Strand Break Response R-HSA-5693606 4.779019e-10 9.321 0 0
Cell-cell junction organization R-HSA-421270 4.944353e-10 9.306 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.480673e-10 9.261 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.167438e-10 9.145 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.030238e-10 9.153 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.167438e-10 9.145 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.174117e-10 9.088 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.505580e-09 8.822 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.505580e-09 8.822 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.537140e-09 8.813 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.505580e-09 8.822 0 0
RNA Polymerase I Transcription R-HSA-73864 1.956878e-09 8.708 0 0
HATs acetylate histones R-HSA-3214847 2.071503e-09 8.684 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.476453e-09 8.606 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.779910e-09 8.556 0 0
Amyloid fiber formation R-HSA-977225 2.779910e-09 8.556 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.787148e-09 8.555 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.900020e-09 8.409 0 0
Meiosis R-HSA-1500620 4.354450e-09 8.361 0 0
Viral Infection Pathways R-HSA-9824446 4.531082e-09 8.344 1 0
Base Excision Repair R-HSA-73884 8.221097e-09 8.085 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.295434e-09 8.081 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.102551e-09 8.041 0 0
ESR-mediated signaling R-HSA-8939211 1.170374e-08 7.932 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.227536e-08 7.911 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.504224e-08 7.823 0 0
Mitotic Prophase R-HSA-68875 1.794719e-08 7.746 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.886705e-08 7.724 0 0
Telomere Maintenance R-HSA-157579 1.979656e-08 7.703 0 0
Cell Cycle R-HSA-1640170 2.915903e-08 7.535 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.118146e-08 7.506 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.052612e-08 7.392 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.052612e-08 7.392 0 0
M Phase R-HSA-68886 3.871128e-08 7.412 0 0
Infectious disease R-HSA-5663205 5.149243e-08 7.288 1 0
DNA Replication Pre-Initiation R-HSA-69002 6.172247e-08 7.210 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.525131e-08 7.069 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 9.225474e-08 7.035 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.065076e-07 6.973 0 0
Activation of BH3-only proteins R-HSA-114452 1.142106e-07 6.942 0 0
EPH-Ephrin signaling R-HSA-2682334 1.256962e-07 6.901 0 0
Homology Directed Repair R-HSA-5693538 1.460690e-07 6.835 0 0
Chromosome Maintenance R-HSA-73886 1.822146e-07 6.739 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.105148e-07 6.677 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.420277e-07 6.616 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.602751e-07 6.585 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.602751e-07 6.585 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.602751e-07 6.585 0 0
Disease R-HSA-1643685 3.420721e-07 6.466 1 0
Reproduction R-HSA-1474165 3.919610e-07 6.407 0 0
HCMV Early Events R-HSA-9609690 4.024903e-07 6.395 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.115786e-07 6.386 0 0
Co-inhibition by PD-1 R-HSA-389948 4.939469e-07 6.306 0 0
Signaling by NOTCH R-HSA-157118 5.608040e-07 6.251 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.981040e-07 6.223 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.751791e-07 6.171 0 0
Cell Cycle, Mitotic R-HSA-69278 6.809749e-07 6.167 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.125364e-06 5.949 0 0
Cellular Senescence R-HSA-2559583 1.172257e-06 5.931 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.366639e-06 5.864 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.794388e-06 5.746 0 0
DNA Replication R-HSA-69306 1.794388e-06 5.746 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.896693e-06 5.722 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.931761e-06 5.714 1 0
HCMV Late Events R-HSA-9610379 2.235000e-06 5.651 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.310700e-06 5.636 0 0
Cellular responses to stimuli R-HSA-8953897 2.443378e-06 5.612 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.657645e-06 5.576 0 0
Protein ubiquitination R-HSA-8852135 2.664544e-06 5.574 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.155210e-06 5.381 0 0
HCMV Infection R-HSA-9609646 4.813940e-06 5.317 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.053093e-06 5.296 0 0
Ub-specific processing proteases R-HSA-5689880 5.345777e-06 5.272 0 0
Immune System R-HSA-168256 5.411624e-06 5.267 1 0
Regulation of CDH1 Function R-HSA-9764561 5.584792e-06 5.253 0 0
Cellular responses to stress R-HSA-2262752 7.047050e-06 5.152 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.847495e-06 5.007 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.847495e-06 5.007 0 0
Semaphorin interactions R-HSA-373755 9.847495e-06 5.007 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.282615e-05 4.892 0 0
Chromatin modifying enzymes R-HSA-3247509 1.357669e-05 4.867 0 0
Membrane Trafficking R-HSA-199991 1.788924e-05 4.747 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.275698e-05 4.643 0 0
Chromatin organization R-HSA-4839726 2.372016e-05 4.625 0 0
Centrosome maturation R-HSA-380287 2.654062e-05 4.576 0 0
Signaling by WNT R-HSA-195721 2.658225e-05 4.575 0 0
SARS-CoV Infections R-HSA-9679506 2.730834e-05 4.564 1 0
Interleukin-12 signaling R-HSA-9020591 2.861821e-05 4.543 1 1
Deubiquitination R-HSA-5688426 2.933639e-05 4.533 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.346982e-05 4.475 1 0
Vesicle-mediated transport R-HSA-5653656 4.023907e-05 4.395 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.843223e-05 4.315 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.055915e-05 4.296 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.109133e-05 4.292 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.800722e-05 4.237 0 0
Interleukin-12 family signaling R-HSA-447115 6.584026e-05 4.182 1 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.019772e-05 4.154 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.962039e-05 4.099 0 0
HSF1 activation R-HSA-3371511 8.873223e-05 4.052 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.160584e-04 3.935 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.873220e-05 4.006 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.088365e-04 3.963 1 0
Apoptosis R-HSA-109581 1.089705e-04 3.963 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.178627e-04 3.929 1 0
Programmed Cell Death R-HSA-5357801 1.182100e-04 3.927 0 0
FOXO-mediated transcription R-HSA-9614085 1.516941e-04 3.819 0 0
Activation of TRKA receptors R-HSA-187015 1.603920e-04 3.795 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.623560e-04 3.790 0 0
MAP2K and MAPK activation R-HSA-5674135 1.623560e-04 3.790 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.896021e-04 3.722 0 0
Formation of annular gap junctions R-HSA-196025 2.118945e-04 3.674 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.132499e-04 3.671 0 0
Adaptive Immune System R-HSA-1280218 2.234764e-04 3.651 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.302157e-04 3.638 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.420549e-04 3.616 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.533772e-04 3.596 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.533772e-04 3.596 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.533772e-04 3.596 0 0
Signaling by RAS mutants R-HSA-6802949 2.533772e-04 3.596 0 0
Gap junction degradation R-HSA-190873 2.730523e-04 3.564 0 0
Gluconeogenesis R-HSA-70263 2.989980e-04 3.524 0 0
Potential therapeutics for SARS R-HSA-9679191 3.631987e-04 3.440 1 1
RAF/MAP kinase cascade R-HSA-5673001 3.634411e-04 3.440 1 1
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.942340e-04 3.404 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.946464e-04 3.404 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.201503e-04 3.377 0 0
MAPK family signaling cascades R-HSA-5683057 4.207805e-04 3.376 1 0
Smooth Muscle Contraction R-HSA-445355 4.402649e-04 3.356 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.515116e-04 3.345 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.546766e-04 3.342 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.915735e-04 3.308 0 0
Cellular response to heat stress R-HSA-3371556 5.152486e-04 3.288 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.615812e-04 3.251 0 0
DNA Repair R-HSA-73894 5.707510e-04 3.244 0 0
Integrin signaling R-HSA-354192 7.343705e-04 3.134 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.500216e-04 3.125 0 0
Signaling by VEGF R-HSA-194138 6.372361e-04 3.196 0 0
Axon guidance R-HSA-422475 7.349005e-04 3.134 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.811145e-04 3.107 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.043539e-04 3.219 1 1
Developmental Biology R-HSA-1266738 6.912696e-04 3.160 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.908475e-04 3.050 0 0
Extracellular matrix organization R-HSA-1474244 1.026730e-03 2.989 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.028794e-03 2.988 0 0
Glycolysis R-HSA-70171 1.046228e-03 2.980 0 0
Prolonged ERK activation events R-HSA-169893 1.191050e-03 2.924 0 0
TRKA activation by NGF R-HSA-187042 1.246215e-03 2.904 0 0
G2/M Transition R-HSA-69275 1.303572e-03 2.885 0 0
RSV-host interactions R-HSA-9833110 1.307569e-03 2.884 1 0
Nervous system development R-HSA-9675108 1.375747e-03 2.861 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.385155e-03 2.859 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.386021e-03 2.858 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.464090e-03 2.834 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.486697e-03 2.828 0 0
Signaling by ALK in cancer R-HSA-9700206 1.486697e-03 2.828 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.561917e-03 2.806 0 0
Mitotic Prometaphase R-HSA-68877 1.606969e-03 2.794 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.654533e-03 2.781 0 0
Signaling by NTRKs R-HSA-166520 1.687726e-03 2.773 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.771539e-03 2.752 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.241538e-03 2.649 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.244325e-03 2.649 0 0
mRNA Splicing R-HSA-72172 2.254995e-03 2.647 0 0
L1CAM interactions R-HSA-373760 2.307463e-03 2.637 0 0
Glucose metabolism R-HSA-70326 2.396173e-03 2.620 0 0
IRS activation R-HSA-74713 2.410191e-03 2.618 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.562356e-03 2.591 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.782163e-03 2.556 1 1
Regulation of IFNA/IFNB signaling R-HSA-912694 3.079996e-03 2.511 1 1
FGFR2 alternative splicing R-HSA-6803529 3.079996e-03 2.511 0 0
NGF-independant TRKA activation R-HSA-187024 3.127088e-03 2.505 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.672353e-03 2.435 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.699595e-03 2.432 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.789200e-03 2.421 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.931444e-03 2.405 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.948681e-03 2.404 1 0
Sema4D in semaphorin signaling R-HSA-400685 4.088135e-03 2.388 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.821436e-03 2.317 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.821436e-03 2.317 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.859211e-03 2.313 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.712395e-03 2.243 1 1
Signaling by MRAS-complex mutants R-HSA-9660537 5.795268e-03 2.237 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 5.795268e-03 2.237 0 0
Interleukin-23 signaling R-HSA-9020933 5.795268e-03 2.237 0 0
Cilium Assembly R-HSA-5617833 5.907242e-03 2.229 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.265285e-03 2.203 1 1
Signaling by Interleukins R-HSA-449147 6.627612e-03 2.179 1 0
ARMS-mediated activation R-HSA-170984 6.851169e-03 2.164 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.931945e-03 2.101 0 0
PI3K/AKT activation R-HSA-198203 7.987397e-03 2.098 0 0
Signalling to ERKs R-HSA-187687 9.375126e-03 2.028 0 0
Interleukin-2 signaling R-HSA-9020558 9.202236e-03 2.036 1 1
Developmental Lineages of the Mammary Gland R-HSA-9924644 9.440735e-03 2.025 0 0
Signal attenuation R-HSA-74749 7.987397e-03 2.098 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.375126e-03 2.028 0 0
Interleukin-27 signaling R-HSA-9020956 7.987397e-03 2.098 1 1
MAPK1 (ERK2) activation R-HSA-112411 6.851169e-03 2.164 1 1
MAPK3 (ERK1) activation R-HSA-110056 7.987397e-03 2.098 1 1
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.987397e-03 2.098 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.851169e-03 2.164 0 0
Muscle contraction R-HSA-397014 1.013026e-02 1.994 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.931945e-03 2.101 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.910959e-03 2.160 0 0
Generic Transcription Pathway R-HSA-212436 9.421314e-03 2.026 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.013306e-02 1.994 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.013306e-02 1.994 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.013306e-02 1.994 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.013306e-02 1.994 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.013306e-02 1.994 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.013306e-02 1.994 0 0
Interferon alpha/beta signaling R-HSA-909733 1.075855e-02 1.968 1 1
Platelet activation, signaling and aggregation R-HSA-76002 1.100194e-02 1.959 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.150761e-02 1.939 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.186101e-02 1.926 0 0
Interleukin-35 Signalling R-HSA-8984722 1.186101e-02 1.926 1 1
Sensory processing of sound R-HSA-9659379 1.250772e-02 1.903 0 0
Attenuation phase R-HSA-3371568 1.266431e-02 1.897 0 0
Frs2-mediated activation R-HSA-170968 1.330165e-02 1.876 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 1.330165e-02 1.876 1 1
Interleukin-6 signaling R-HSA-1059683 1.330165e-02 1.876 1 1
FLT3 Signaling R-HSA-9607240 1.339147e-02 1.873 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.481429e-02 1.829 0 0
RNA Polymerase II Transcription R-HSA-73857 1.485332e-02 1.828 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.491600e-02 1.826 1 0
PIP3 activates AKT signaling R-HSA-1257604 1.601923e-02 1.795 0 0
Gap junction trafficking R-HSA-190828 1.653472e-02 1.782 0 0
Gene expression (Transcription) R-HSA-74160 1.794515e-02 1.746 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.804926e-02 1.744 0 0
Recycling pathway of L1 R-HSA-437239 1.914053e-02 1.718 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.976848e-02 1.704 0 0
Inhibition of PKR R-HSA-169131 2.016407e-02 1.695 0 0
Gap junction trafficking and regulation R-HSA-157858 2.099671e-02 1.678 0 0
Signaling by Hippo R-HSA-2028269 2.155350e-02 1.666 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.172498e-02 1.663 1 1
HSF1-dependent transactivation R-HSA-3371571 2.294828e-02 1.639 0 0
Leishmania phagocytosis R-HSA-9664417 2.297962e-02 1.639 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.297962e-02 1.639 0 0
Parasite infection R-HSA-9664407 2.297962e-02 1.639 0 0
Ephrin signaling R-HSA-3928664 2.340282e-02 1.631 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.524533e-02 1.598 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.531498e-02 1.597 0 0
Rap1 signalling R-HSA-392517 2.531498e-02 1.597 0 0
Other interleukin signaling R-HSA-449836 2.531498e-02 1.597 1 1
Signal transduction by L1 R-HSA-445144 2.728852e-02 1.564 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.824434e-02 1.549 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.833735e-02 1.548 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.913883e-02 1.536 0 0
Metabolism of RNA R-HSA-8953854 2.916263e-02 1.535 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.932202e-02 1.533 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.937488e-02 1.532 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.009404e-02 1.522 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 3.009404e-02 1.522 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.141409e-02 1.503 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.290773e-02 1.483 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.295476e-02 1.482 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.356333e-02 1.474 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 3.356333e-02 1.474 1 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.512499e-02 1.454 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.538161e-02 1.451 0 0
Interleukin-20 family signaling R-HSA-8854691 3.576840e-02 1.447 1 1
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.576840e-02 1.447 0 0
Syndecan interactions R-HSA-3000170 3.576840e-02 1.447 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.665330e-02 1.436 0 0
Signaling by PTK6 R-HSA-8848021 3.665330e-02 1.436 0 0
Interleukin-6 family signaling R-HSA-6783589 3.802795e-02 1.420 1 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.802795e-02 1.420 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.802795e-02 1.420 0 0
Neurodegenerative Diseases R-HSA-8863678 3.802795e-02 1.420 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.992398e-02 1.399 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 3.992398e-02 1.399 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 3.992398e-02 1.399 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 3.992398e-02 1.399 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.992398e-02 1.399 0 0
NTF3 activates NTRK3 signaling R-HSA-9034013 3.992398e-02 1.399 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.992398e-02 1.399 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.992398e-02 1.399 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.992398e-02 1.399 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.992398e-02 1.399 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.992398e-02 1.399 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.992398e-02 1.399 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.992398e-02 1.399 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.992398e-02 1.399 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.992398e-02 1.399 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.992398e-02 1.399 0 0
Interleukin-7 signaling R-HSA-1266695 4.034068e-02 1.394 1 1
MET activates PTK2 signaling R-HSA-8874081 4.270527e-02 1.370 0 0
PLC-gamma1 signalling R-HSA-167021 4.965490e-02 1.304 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.965490e-02 1.304 0 0
Axonal growth stimulation R-HSA-209563 4.965490e-02 1.304 0 0
Signalling to STAT3 R-HSA-198745 4.965490e-02 1.304 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.928778e-02 1.227 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.928778e-02 1.227 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.882362e-02 1.162 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.826337e-02 1.106 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.826337e-02 1.106 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 7.826337e-02 1.106 0 0
Erythropoietin activates STAT5 R-HSA-9027283 8.760801e-02 1.057 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 8.760801e-02 1.057 0 0
Striated Muscle Contraction R-HSA-390522 6.334074e-02 1.198 0 0
Downstream signal transduction R-HSA-186763 5.526246e-02 1.258 0 0
RAF activation R-HSA-5673000 6.611722e-02 1.180 0 0
Interleukin-2 family signaling R-HSA-451927 8.357886e-02 1.078 1 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.611722e-02 1.180 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.882362e-02 1.162 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 7.826337e-02 1.106 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.009766e-02 1.300 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.265721e-02 1.279 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.265721e-02 1.279 0 0
MET interacts with TNS proteins R-HSA-8875513 4.965490e-02 1.304 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.512047e-02 1.346 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.178910e-02 1.144 0 0
MET promotes cell motility R-HSA-8875878 7.761243e-02 1.110 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 8.661322e-02 1.062 0 0
NADE modulates death signalling R-HSA-205025 5.928778e-02 1.227 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.057827e-02 1.094 0 0
Platelet degranulation R-HSA-114608 5.825363e-02 1.235 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.928778e-02 1.227 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.697418e-02 1.174 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 7.826337e-02 1.106 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.826337e-02 1.106 0 0
VLDL assembly R-HSA-8866423 8.760801e-02 1.057 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.526246e-02 1.258 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.913321e-02 1.309 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.369815e-02 1.270 1 1
Elastic fibre formation R-HSA-1566948 7.761243e-02 1.110 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 4.913321e-02 1.309 0 0
Signaling by NOTCH4 R-HSA-9013694 5.215448e-02 1.283 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.042149e-02 1.219 0 0
Signaling by FGFR2 R-HSA-5654738 6.174106e-02 1.209 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.512047e-02 1.346 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.791223e-02 1.237 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.057827e-02 1.094 0 0
Parasitic Infection Pathways R-HSA-9824443 8.874202e-02 1.052 0 0
Leishmania infection R-HSA-9658195 8.874202e-02 1.052 0 0
Negative regulation of MAPK pathway R-HSA-5675221 8.968035e-02 1.047 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.277929e-02 1.033 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.590910e-02 1.018 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.590910e-02 1.018 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 9.685848e-02 1.014 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 9.685848e-02 1.014 0 0
IFNG signaling activates MAPKs R-HSA-9732724 9.685848e-02 1.014 1 1
SOS-mediated signalling R-HSA-112412 9.685848e-02 1.014 0 0
LDL remodeling R-HSA-8964041 9.685848e-02 1.014 0 0
CHL1 interactions R-HSA-447041 9.685848e-02 1.014 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.906883e-02 1.004 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.000328e-01 1.000 1 0
Signaling by FGFR R-HSA-190236 1.010113e-01 0.996 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.030840e-01 0.987 0 0
Apoptotic execution phase R-HSA-75153 1.054744e-01 0.977 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 1.060157e-01 0.975 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.060157e-01 0.975 0 0
Interleukin-9 signaling R-HSA-8985947 1.060157e-01 0.975 1 1
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.060157e-01 0.975 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.119889e-01 0.951 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.136966e-01 0.944 0 0
Interleukin-21 signaling R-HSA-9020958 1.150807e-01 0.939 1 1
ALK mutants bind TKIs R-HSA-9700645 1.150807e-01 0.939 0 0
p75NTR regulates axonogenesis R-HSA-193697 1.150807e-01 0.939 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.150807e-01 0.939 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.150807e-01 0.939 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.150807e-01 0.939 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.150807e-01 0.939 0 0
Interferon Signaling R-HSA-913531 1.202939e-01 0.920 1 0
Hemostasis R-HSA-109582 1.211811e-01 0.917 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.240543e-01 0.906 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.240543e-01 0.906 0 0
Regulation of CDH11 function R-HSA-9762292 1.240543e-01 0.906 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 1.240543e-01 0.906 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.240543e-01 0.906 0 0
Signaling by Leptin R-HSA-2586552 1.240543e-01 0.906 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.253170e-01 0.902 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.329374e-01 0.876 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.329374e-01 0.876 0 0
vRNP Assembly R-HSA-192905 1.329374e-01 0.876 0 0
Chylomicron assembly R-HSA-8963888 1.329374e-01 0.876 0 0
PECAM1 interactions R-HSA-210990 1.329374e-01 0.876 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 1.329374e-01 0.876 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.384000e-01 0.859 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 1.390005e-01 0.857 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.417310e-01 0.849 0 0
Influenza Infection R-HSA-168255 1.447569e-01 0.839 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.504360e-01 0.823 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.504360e-01 0.823 0 0
Interleukin-15 signaling R-HSA-8983432 1.504360e-01 0.823 1 1
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.504360e-01 0.823 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.504360e-01 0.823 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.504360e-01 0.823 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.504360e-01 0.823 0 0
Regulation of IFNG signaling R-HSA-877312 1.504360e-01 0.823 1 1
VLDLR internalisation and degradation R-HSA-8866427 1.504360e-01 0.823 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.504360e-01 0.823 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.504360e-01 0.823 0 0
Signaling by ERBB2 R-HSA-1227986 1.529902e-01 0.815 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.565301e-01 0.805 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.590532e-01 0.798 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.590532e-01 0.798 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.590532e-01 0.798 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.590532e-01 0.798 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.590532e-01 0.798 0 0
Signaling by PDGF R-HSA-186797 1.600855e-01 0.796 0 0
MHC class II antigen presentation R-HSA-2132295 1.647335e-01 0.783 0 0
IGF1R signaling cascade R-HSA-2428924 1.672403e-01 0.777 0 0
Insulin receptor signalling cascade R-HSA-74751 1.672403e-01 0.777 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.675835e-01 0.776 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.675835e-01 0.776 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.675835e-01 0.776 0 0
Signal regulatory protein family interactions R-HSA-391160 1.675835e-01 0.776 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.708385e-01 0.767 0 0
Erythropoietin activates RAS R-HSA-9027284 1.760279e-01 0.754 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.760279e-01 0.754 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.760279e-01 0.754 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.760279e-01 0.754 0 0
DCC mediated attractive signaling R-HSA-418885 1.760279e-01 0.754 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.760279e-01 0.754 0 0
Protein lipoylation R-HSA-9857492 1.760279e-01 0.754 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.760279e-01 0.754 0 0
Protein methylation R-HSA-8876725 1.760279e-01 0.754 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.760279e-01 0.754 0 0
Other semaphorin interactions R-HSA-416700 1.760279e-01 0.754 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 1.843870e-01 0.734 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.843870e-01 0.734 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.843870e-01 0.734 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.843870e-01 0.734 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.843870e-01 0.734 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.926619e-01 0.715 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.926619e-01 0.715 0 0
Fibronectin matrix formation R-HSA-1566977 1.926619e-01 0.715 0 0
ECM proteoglycans R-HSA-3000178 1.926777e-01 0.715 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.000385e-01 0.699 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.000385e-01 0.699 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.008534e-01 0.697 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.008534e-01 0.697 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.008534e-01 0.697 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.008534e-01 0.697 0 0
Tie2 Signaling R-HSA-210993 2.089622e-01 0.680 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.089622e-01 0.680 0 0
Neutrophil degranulation R-HSA-6798695 2.163523e-01 0.665 0 0
Regulation of signaling by CBL R-HSA-912631 2.169892e-01 0.664 0 0
The NLRP3 inflammasome R-HSA-844456 2.169892e-01 0.664 0 0
Integrin cell surface interactions R-HSA-216083 2.185756e-01 0.660 0 0
Interleukin-10 signaling R-HSA-6783783 2.185756e-01 0.660 1 1
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.249353e-01 0.648 0 0
PKR-mediated signaling R-HSA-9833482 2.260335e-01 0.646 0 0
Signaling by MET R-HSA-6806834 2.260335e-01 0.646 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.328012e-01 0.633 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.328012e-01 0.633 0 0
Signalling to RAS R-HSA-167044 2.328012e-01 0.633 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.328012e-01 0.633 0 0
Basigin interactions R-HSA-210991 2.328012e-01 0.633 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.335100e-01 0.632 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.405878e-01 0.619 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.405878e-01 0.619 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.405878e-01 0.619 0 0
Ribavirin ADME R-HSA-9755088 2.405878e-01 0.619 0 0
mTORC1-mediated signalling R-HSA-166208 2.482959e-01 0.605 0 0
LDL clearance R-HSA-8964038 2.482959e-01 0.605 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.485041e-01 0.605 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.485041e-01 0.605 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.485041e-01 0.605 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.485041e-01 0.605 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.559261e-01 0.592 1 1
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.559261e-01 0.592 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.559261e-01 0.592 0 0
Formation of the ureteric bud R-HSA-9830674 2.559261e-01 0.592 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.559261e-01 0.592 0 0
Growth hormone receptor signaling R-HSA-982772 2.559261e-01 0.592 0 0
Death Receptor Signaling R-HSA-73887 2.561302e-01 0.592 0 0
Autophagy R-HSA-9612973 2.615835e-01 0.582 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 2.634794e-01 0.579 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.634794e-01 0.579 0 0
Mitochondrial RNA degradation R-HSA-9836573 2.634794e-01 0.579 0 0
Post-translational protein modification R-HSA-597592 2.638048e-01 0.579 0 0
Laminin interactions R-HSA-3000157 2.709565e-01 0.567 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.709565e-01 0.567 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.709565e-01 0.567 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 2.709565e-01 0.567 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.783581e-01 0.555 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 2.783581e-01 0.555 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.785602e-01 0.555 0 0
Signaling by Insulin receptor R-HSA-74752 2.785602e-01 0.555 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 2.785602e-01 0.555 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.856850e-01 0.544 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.856850e-01 0.544 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.856850e-01 0.544 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.856850e-01 0.544 0 0
Insulin processing R-HSA-264876 2.856850e-01 0.544 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 2.898218e-01 0.538 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.898218e-01 0.538 0 0
HIV elongation arrest and recovery R-HSA-167287 2.929380e-01 0.533 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.929380e-01 0.533 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.929380e-01 0.533 0 0
Insulin receptor recycling R-HSA-77387 2.929380e-01 0.533 0 0
Inflammasomes R-HSA-622312 2.929380e-01 0.533 0 0
Signaling by Erythropoietin R-HSA-9006335 3.001178e-01 0.523 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.001178e-01 0.523 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.010632e-01 0.521 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.048043e-01 0.516 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.072251e-01 0.513 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.072251e-01 0.513 0 0
DAP12 signaling R-HSA-2424491 3.072251e-01 0.513 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.072251e-01 0.513 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 3.072251e-01 0.513 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.122754e-01 0.505 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.142607e-01 0.503 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.142607e-01 0.503 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.142607e-01 0.503 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 3.142607e-01 0.503 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.212253e-01 0.493 0 0
Developmental Cell Lineages R-HSA-9734767 3.261552e-01 0.487 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.281195e-01 0.484 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.281195e-01 0.484 0 0
G-protein beta:gamma signalling R-HSA-397795 3.281195e-01 0.484 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.281195e-01 0.484 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.281195e-01 0.484 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.349442e-01 0.475 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.349442e-01 0.475 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.349442e-01 0.475 0 0
eNOS activation R-HSA-203615 3.416999e-01 0.466 0 0
Nuclear import of Rev protein R-HSA-180746 3.416999e-01 0.466 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.483875e-01 0.458 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.493344e-01 0.457 0 0
GPVI-mediated activation cascade R-HSA-114604 3.550075e-01 0.450 0 0
RET signaling R-HSA-8853659 3.550075e-01 0.450 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 3.569365e-01 0.447 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.615606e-01 0.442 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.615606e-01 0.442 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 3.680476e-01 0.434 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.680476e-01 0.434 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.680476e-01 0.434 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.712566e-01 0.430 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.744691e-01 0.427 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.744691e-01 0.427 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.744691e-01 0.427 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.744691e-01 0.427 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.808257e-01 0.419 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.808257e-01 0.419 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.808257e-01 0.419 0 0
HIV Transcription Elongation R-HSA-167169 3.808257e-01 0.419 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.808257e-01 0.419 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.808257e-01 0.419 0 0
Generation of second messenger molecules R-HSA-202433 3.808257e-01 0.419 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.808257e-01 0.419 0 0
Aggrephagy R-HSA-9646399 3.808257e-01 0.419 0 0
Rab regulation of trafficking R-HSA-9007101 3.857099e-01 0.414 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.871181e-01 0.412 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.871181e-01 0.412 0 0
MTOR signalling R-HSA-165159 3.995129e-01 0.398 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.000190e-01 0.398 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 4.000190e-01 0.398 0 0
Innate Immune System R-HSA-168249 4.017224e-01 0.396 0 0
Bacterial Infection Pathways R-HSA-9824439 4.078719e-01 0.389 0 0
Host Interactions of HIV factors R-HSA-162909 4.106491e-01 0.387 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.116585e-01 0.385 0 0
Cyclin D associated events in G1 R-HSA-69231 4.116585e-01 0.385 0 0
G1 Phase R-HSA-69236 4.116585e-01 0.385 0 0
Netrin-1 signaling R-HSA-373752 4.116585e-01 0.385 0 0
DAP12 interactions R-HSA-2172127 4.116585e-01 0.385 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.176394e-01 0.379 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.176394e-01 0.379 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.235599e-01 0.373 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.235599e-01 0.373 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.235599e-01 0.373 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.235599e-01 0.373 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.235599e-01 0.373 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.235599e-01 0.373 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.294205e-01 0.367 0 0
Co-stimulation by CD28 R-HSA-389356 4.352220e-01 0.361 0 0
GPER1 signaling R-HSA-9634597 4.352220e-01 0.361 0 0
Plasma lipoprotein remodeling R-HSA-8963899 4.352220e-01 0.361 0 0
Degradation of CDH1 R-HSA-9766229 4.409648e-01 0.356 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.409648e-01 0.356 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.409648e-01 0.356 0 0
PI3K Cascade R-HSA-109704 4.466495e-01 0.350 0 0
Azathioprine ADME R-HSA-9748787 4.466495e-01 0.350 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.522768e-01 0.345 0 0
Branched-chain amino acid catabolism R-HSA-70895 4.522768e-01 0.345 0 0
mRNA 3'-end processing R-HSA-72187 4.578473e-01 0.339 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.578473e-01 0.339 0 0
HIV Infection R-HSA-162906 4.611891e-01 0.336 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.633614e-01 0.334 0 0
Translation initiation complex formation R-HSA-72649 4.688197e-01 0.329 0 0
Signaling by Hedgehog R-HSA-5358351 4.690355e-01 0.329 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.742229e-01 0.324 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.795715e-01 0.319 0 0
NRAGE signals death through JNK R-HSA-193648 4.795715e-01 0.319 0 0
Metabolism of nucleotides R-HSA-15869 4.845996e-01 0.315 0 0
IRS-mediated signalling R-HSA-112399 4.848659e-01 0.314 0 0
Dectin-2 family R-HSA-5621480 4.848659e-01 0.314 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.848659e-01 0.314 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.855526e-01 0.314 0 0
Cell surface interactions at the vascular wall R-HSA-202733 4.871714e-01 0.312 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.901069e-01 0.310 0 0
snRNP Assembly R-HSA-191859 4.952948e-01 0.305 0 0
Metabolism of non-coding RNA R-HSA-194441 4.952948e-01 0.305 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.017500e-01 0.300 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.055138e-01 0.296 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.055138e-01 0.296 0 0
Mitochondrial protein import R-HSA-1268020 5.105459e-01 0.292 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.105459e-01 0.292 0 0
tRNA processing in the nucleus R-HSA-6784531 5.105459e-01 0.292 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 5.113111e-01 0.291 0 0
Complex I biogenesis R-HSA-6799198 5.155271e-01 0.288 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.155271e-01 0.288 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.204580e-01 0.284 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.269786e-01 0.278 0 0
HIV Life Cycle R-HSA-162587 5.331508e-01 0.273 0 0
Kidney development R-HSA-9830369 5.349532e-01 0.272 0 0
Transcription of the HIV genome R-HSA-167172 5.396875e-01 0.268 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 5.396875e-01 0.268 0 0
Regulated Necrosis R-HSA-5218859 5.396875e-01 0.268 0 0
Signaling by TGFB family members R-HSA-9006936 5.423062e-01 0.266 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.490128e-01 0.260 0 0
COPII-mediated vesicle transport R-HSA-204005 5.490128e-01 0.260 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.490128e-01 0.260 0 0
Metabolism of cofactors R-HSA-8978934 5.536048e-01 0.257 0 0
Separation of Sister Chromatids R-HSA-2467813 5.543200e-01 0.256 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.581503e-01 0.253 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.671039e-01 0.246 0 0
Signaling by ERBB4 R-HSA-1236394 5.671039e-01 0.246 0 0
UCH proteinases R-HSA-5689603 5.758770e-01 0.240 0 0
Leishmania parasite growth and survival R-HSA-9664433 5.833766e-01 0.234 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 5.833766e-01 0.234 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.844735e-01 0.233 0 0
PCP/CE pathway R-HSA-4086400 5.844735e-01 0.233 0 0
G alpha (12/13) signalling events R-HSA-416482 5.844735e-01 0.233 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.890191e-01 0.230 0 0
Metabolism of proteins R-HSA-392499 5.980721e-01 0.223 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.092374e-01 0.215 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.132197e-01 0.212 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.210636e-01 0.207 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.249260e-01 0.204 0 0
Pyruvate metabolism R-HSA-70268 6.249260e-01 0.204 0 0
Post NMDA receptor activation events R-HSA-438064 6.249260e-01 0.204 0 0
Peptide chain elongation R-HSA-156902 6.287494e-01 0.202 0 0
Selective autophagy R-HSA-9663891 6.287494e-01 0.202 0 0
Protein folding R-HSA-391251 6.472927e-01 0.189 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.508893e-01 0.186 0 0
FCGR activation R-HSA-2029481 6.508893e-01 0.186 0 0
Mitochondrial protein degradation R-HSA-9837999 6.544496e-01 0.184 0 0
Collagen formation R-HSA-1474290 6.544496e-01 0.184 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.547959e-01 0.184 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.596807e-01 0.181 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.614621e-01 0.179 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 6.649151e-01 0.177 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.649151e-01 0.177 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.649151e-01 0.177 0 0
Translation R-HSA-72766 6.751942e-01 0.171 0 0
Hedgehog 'off' state R-HSA-5610787 6.783807e-01 0.169 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.849104e-01 0.164 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 6.881257e-01 0.162 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.913084e-01 0.160 0 0
Mitotic Anaphase R-HSA-68882 6.945755e-01 0.158 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.967942e-01 0.157 0 0
Nucleotide Excision Repair R-HSA-5696398 6.975772e-01 0.156 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.067439e-01 0.151 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.067439e-01 0.151 0 0
TCR signaling R-HSA-202403 7.127011e-01 0.147 0 0
Inositol phosphate metabolism R-HSA-1483249 7.185380e-01 0.144 0 0
FCERI mediated MAPK activation R-HSA-2871796 7.185380e-01 0.144 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 7.223961e-01 0.141 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.326196e-01 0.135 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 7.326196e-01 0.135 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.353508e-01 0.134 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.353508e-01 0.134 0 0
Peptide hormone metabolism R-HSA-2980736 7.380542e-01 0.132 0 0
Formation of the cornified envelope R-HSA-6809371 7.562249e-01 0.121 0 0
G1/S Transition R-HSA-69206 7.611825e-01 0.119 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.636235e-01 0.117 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 7.800305e-01 0.108 0 0
Circadian clock R-HSA-9909396 7.800305e-01 0.108 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.910518e-01 0.102 0 0
Cellular response to chemical stress R-HSA-9711123 7.933529e-01 0.101 0 0
Mitochondrial translation R-HSA-5368287 7.953050e-01 0.099 0 0
Macroautophagy R-HSA-1632852 8.015241e-01 0.096 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.134043e-01 0.090 0 0
S Phase R-HSA-69242 8.172052e-01 0.088 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.209291e-01 0.086 0 0
Protein localization R-HSA-9609507 8.263740e-01 0.083 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.350856e-01 0.078 0 0
Interferon gamma signaling R-HSA-877300 8.367750e-01 0.077 1 1
Regulation of TP53 Activity R-HSA-5633007 8.384473e-01 0.077 0 0
SLC transporter disorders R-HSA-5619102 8.496858e-01 0.071 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.557553e-01 0.068 0 0
tRNA processing R-HSA-72306 8.557553e-01 0.068 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.572342e-01 0.067 0 0
G alpha (s) signalling events R-HSA-418555 8.572342e-01 0.067 0 0
Respiratory electron transport R-HSA-611105 8.671730e-01 0.062 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.801897e-01 0.055 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 8.844422e-01 0.053 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.973751e-01 0.047 0 0
Keratinization R-HSA-6805567 9.015284e-01 0.045 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.074472e-01 0.042 0 0
Drug ADME R-HSA-9748784 9.130122e-01 0.040 0 0
rRNA processing R-HSA-72312 9.247374e-01 0.034 0 0
Fatty acid metabolism R-HSA-8978868 9.339394e-01 0.030 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.355613e-01 0.029 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.418751e-01 0.026 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.532713e-01 0.021 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.551713e-01 0.020 0 0
Neuronal System R-HSA-112316 9.609602e-01 0.017 0 0
Transmission across Chemical Synapses R-HSA-112315 9.707245e-01 0.013 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.809027e-01 0.008 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.845014e-01 0.007 0 0
Diseases of metabolism R-HSA-5668914 9.902189e-01 0.004 0 0
Biological oxidations R-HSA-211859 9.964332e-01 0.002 0 0
GPCR downstream signalling R-HSA-388396 9.976427e-01 0.001 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.986936e-01 0.001 0 0
Signaling by GPCR R-HSA-372790 9.989380e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.991151e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.996844e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999982e-01 0.000 0 0
Metabolism R-HSA-1430728 9.999994e-01 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways