PKN2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O14617 S658 Sugiyama AP3D1 PRO0039 DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15553 S208 SIGNOR|EPSD|PSP MEFV MEF TRIM20 PGPCRALEGGQAEVRLRRNAssAGRLQGLAGGAPGQKECRP
O15553 S242 SIGNOR|EPSD|PSP MEFV MEF TRIM20 GQKECRPFEVYLPSGKMRPRsLEVTISTGEKAPANPEILLT
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O76021 S314 Sugiyama RSL1D1 CATX11 CSIG PBK1 L12 RNFEKQKERKKKRQQARKtAsVLsKDDVAPEsGDtTVKKPE
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95835 S464 Sugiyama LATS1 WARTS SPSSGHEIPTWQPNIPVRsNsFNNPLGNRASHSANSQPSAT
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09132 S69 Sugiyama SRP19 IQDVCSAVGLNVFLEKNKMYsREWNRDVQYRGRVRVQLKQE
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P15880 S190 Sugiyama RPS2 RPS4 WGNKIGKPHTVPCKVTGRCGsVLVRLIPAPRGtGIVsAPVP
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P29474 S1179 GPS6|PSP NOS3 IFGLTLRTQEVTSRIRtQsFsLQERQLRGAVPWAFDPPGSD
P32969 S182 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 QQATTVKNKDIRKFLDGIyVsEKGtVQQADE__________
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396 S457 Sugiyama ACLY FLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQD
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61313 Y6 Sugiyama RPL15 EC45 TCBAP0781 _______________MGAYKyIQELWRKKQSDVMRFLLRVR
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84098 S122 Sugiyama RPL19 LRRLLRRYRESKKIDRHMyHsLyLKVKGNVFKNKRILMEHI
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q14153 S167 Sugiyama FAM53B KIAA0140 SMP YsGGsVQRYSNGFSTMQRsssFSLPSRANVLssPCDQAGLH
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q16513 S183 Sugiyama PKN2 PRK2 PRKCL2 sNGSsKDRKLHGtAQQLLQDsKTKIEVIRMQILQAVQTNEL
Q16513 S360 Sugiyama PKN2 PRK2 PRKCL2 DILENVPGRSKATSVALPGWsPsEtRssFMsRTSKSKSGSS
Q16513 S362 Sugiyama PKN2 PRK2 PRKCL2 LENVPGRSKATSVALPGWsPsEtRssFMsRTSKSKSGSSRN
Q16513 S37 Sugiyama PKN2 PRK2 PRKCL2 GDsRsLPFSENVsAVQKLDFsDtMVQQKLDDIKDRIKREIR
Q16513 S370 Sugiyama PKN2 PRK2 PRKCL2 KATSVALPGWsPsEtRssFMsRTSKSKSGSSRNLLKTDDLS
Q16513 S582 Sugiyama PKN2 PRK2 PRKCL2 tVTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQD
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16513 S590 Sugiyama PKN2 PRK2 PRKCL2 LEPEPPPAPPRAssLGEIDEssELRVLDIPGQDsEtVFDIQ
Q16513 S603 Sugiyama PKN2 PRK2 PRKCL2 sLGEIDEssELRVLDIPGQDsEtVFDIQNDRNsILPKsQsE
Q16513 S615 Sugiyama PKN2 PRK2 PRKCL2 VLDIPGQDsEtVFDIQNDRNsILPKsQsEyKPDtPQsGLEy
Q16513 S631 Sugiyama PKN2 PRK2 PRKCL2 NDRNsILPKsQsEyKPDtPQsGLEysGIQELEDRRSQQRFQ
Q16513 S636 Sugiyama PKN2 PRK2 PRKCL2 ILPKsQsEyKPDtPQsGLEysGIQELEDRRSQQRFQFNLQD
Q16513 T121 Sugiyama PKN2 PRK2 PRKCL2 QELNAHIVVsDPEDItDCPRtPDtPNNDPRCSTSNNRLKAL
Q16513 T124 Sugiyama PKN2 PRK2 PRKCL2 NAHIVVsDPEDItDCPRtPDtPNNDPRCSTSNNRLKALQKQ
Q16513 T175 Sugiyama PKN2 PRK2 PRKCL2 AENMIQMYsNGSsKDRKLHGtAQQLLQDsKTKIEVIRMQIL
Q16513 T364 Sugiyama PKN2 PRK2 PRKCL2 NVPGRSKATSVALPGWsPsEtRssFMsRTSKSKSGSSRNLL
Q16513 T39 Sugiyama PKN2 PRK2 PRKCL2 sRsLPFSENVsAVQKLDFsDtMVQQKLDDIKDRIKREIRKE
Q16513 T628 Sugiyama PKN2 PRK2 PRKCL2 DIQNDRNsILPKsQsEyKPDtPQsGLEysGIQELEDRRSQQ
Q16513 T958 Sugiyama PKN2 PRK2 PRKCL2 RGREDVSNFDDEFtsEAPILtPPREPRILsEEEQEMFRDFD
Q16513 Y624 Sugiyama PKN2 PRK2 PRKCL2 EtVFDIQNDRNsILPKsQsEyKPDtPQsGLEysGIQELEDR
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5SYE7 S1495 Sugiyama NHSL1 C6orf63 KIAA1357 KNRRAQEEWAKNEGLMPRsLsFsGPRYGRSRTPPSAASSRY
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IZ21 S590 Sugiyama PHACTR4 PRO2963 SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q9BX95 S112 Sugiyama SGPP1 SPP1 GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9BX95 T114 Sugiyama SGPP1 SPP1 AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9NR19 S30 Sugiyama ACSS2 ACAS2 sGsGSRGQEEAGAGGRARsWsPPPEVsRSAHVPSLQRYREL
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9UKV8 S387 Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 2.584599e-13 12.588 1 0
Cell Cycle R-HSA-1640170 2.333356e-12 11.632 0 0
Cell Cycle, Mitotic R-HSA-69278 3.724897e-10 9.429 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 8.045067e-10 9.094 0 0
Cell Cycle Checkpoints R-HSA-69620 1.109205e-09 8.955 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.325163e-09 8.364 0 0
Axon guidance R-HSA-422475 5.027946e-09 8.299 0 0
Meiotic synapsis R-HSA-1221632 7.435116e-09 8.129 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.142743e-08 7.942 0 0
DNA methylation R-HSA-5334118 1.910711e-08 7.719 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.113617e-08 7.675 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.587198e-08 7.587 0 0
Packaging Of Telomere Ends R-HSA-171306 3.506868e-08 7.455 0 0
Chromatin modifying enzymes R-HSA-3247509 3.352973e-08 7.475 0 0
Apoptotic execution phase R-HSA-75153 3.386572e-08 7.470 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.506868e-08 7.455 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.783457e-08 7.422 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.940607e-08 7.404 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.076694e-08 7.216 0 0
HATs acetylate histones R-HSA-3214847 5.999055e-08 7.222 0 0
Meiosis R-HSA-1500620 7.022976e-08 7.153 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.430212e-08 7.129 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.354591e-07 6.868 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.539013e-07 6.813 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.539013e-07 6.813 0 0
M Phase R-HSA-68886 1.487394e-07 6.828 0 0
Nervous system development R-HSA-9675108 1.590729e-07 6.798 0 0
HDACs deacetylate histones R-HSA-3214815 1.832881e-07 6.737 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.208152e-07 6.656 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.208152e-07 6.656 0 0
Cellular Senescence R-HSA-2559583 2.149668e-07 6.668 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.459914e-07 6.609 0 0
NRAGE signals death through JNK R-HSA-193648 2.477601e-07 6.606 0 0
Chromatin organization R-HSA-4839726 2.666642e-07 6.574 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.191418e-07 6.496 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.388079e-07 6.470 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.101495e-07 6.387 0 0
Diseases of programmed cell death R-HSA-9645723 5.247065e-07 6.280 0 0
Meiotic recombination R-HSA-912446 6.261255e-07 6.203 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.252760e-07 6.204 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.728523e-07 6.112 0 0
Cleavage of the damaged purine R-HSA-110331 7.728523e-07 6.112 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.017804e-07 6.096 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 9.109128e-07 6.041 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.010253e-06 5.996 0 0
Depurination R-HSA-73927 1.095956e-06 5.960 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.177788e-06 5.929 0 0
Mitotic Prophase R-HSA-68875 1.182746e-06 5.927 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.227288e-06 5.911 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.438613e-06 5.842 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.584214e-06 5.800 0 0
Reproduction R-HSA-1474165 1.715616e-06 5.766 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.851107e-06 5.733 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.028714e-06 5.693 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.028714e-06 5.693 0 0
Signaling by Hippo R-HSA-2028269 2.167317e-06 5.664 0 0
Defective pyroptosis R-HSA-9710421 2.162993e-06 5.665 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.405024e-06 5.619 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.924521e-06 5.534 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.551990e-06 5.450 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.934927e-06 5.405 0 0
Nucleosome assembly R-HSA-774815 3.944710e-06 5.404 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.944710e-06 5.404 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.488668e-06 5.188 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.626526e-06 5.179 0 0
G alpha (12/13) signalling events R-HSA-416482 7.095940e-06 5.149 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.553335e-06 5.068 0 0
Mitotic Spindle Checkpoint R-HSA-69618 9.016209e-06 5.045 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.092847e-05 4.961 0 0
DNA Double Strand Break Response R-HSA-5693606 1.296305e-05 4.887 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.617705e-05 4.791 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.780905e-05 4.749 0 0
Depyrimidination R-HSA-73928 1.780905e-05 4.749 0 0
Death Receptor Signaling R-HSA-73887 1.869767e-05 4.728 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.410448e-05 4.618 0 0
mRNA 3'-end processing R-HSA-72187 2.563984e-05 4.591 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.058065e-05 4.515 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.044057e-05 4.517 0 0
Signaling by VEGF R-HSA-194138 3.781576e-05 4.422 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.084018e-05 4.389 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.175633e-05 4.286 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.294553e-05 4.276 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.795970e-05 4.168 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.874695e-05 4.163 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 7.068346e-05 4.151 0 0
Telomere Maintenance R-HSA-157579 7.069614e-05 4.151 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.394921e-05 4.076 0 0
Chromosome Maintenance R-HSA-73886 8.394921e-05 4.076 0 0
Netrin-1 signaling R-HSA-373752 9.212292e-05 4.036 0 0
Cell-Cell communication R-HSA-1500931 1.008022e-04 3.997 0 0
Apoptosis R-HSA-109581 1.047623e-04 3.980 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.081106e-04 3.966 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.097954e-04 3.959 0 0
Rap1 signalling R-HSA-392517 1.107560e-04 3.956 0 0
Homology Directed Repair R-HSA-5693538 1.161396e-04 3.935 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.159736e-04 3.936 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.159736e-04 3.936 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.149095e-04 3.940 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.419668e-04 3.848 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.514997e-04 3.820 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.515339e-04 3.819 0 0
Regulation of TP53 Activity R-HSA-5633007 1.596927e-04 3.797 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.671338e-04 3.777 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.804586e-04 3.744 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.961740e-04 3.707 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.983819e-04 3.702 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.986735e-04 3.702 0 0
Amyloid fiber formation R-HSA-977225 1.986735e-04 3.702 0 0
G2/M Checkpoints R-HSA-69481 2.177006e-04 3.662 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.217709e-04 3.654 0 0
Cell junction organization R-HSA-446728 2.373717e-04 3.625 0 0
RNA Polymerase I Transcription R-HSA-73864 2.796988e-04 3.553 0 0
Mitotic Anaphase R-HSA-68882 3.174508e-04 3.498 0 0
EPH-Ephrin signaling R-HSA-2682334 3.104858e-04 3.508 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.194691e-04 3.496 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.385751e-04 3.470 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.385751e-04 3.470 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.385751e-04 3.470 0 0
Programmed Cell Death R-HSA-5357801 3.393132e-04 3.469 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.491609e-04 3.457 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.608856e-04 3.443 0 0
Gene Silencing by RNA R-HSA-211000 3.682419e-04 3.434 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.891249e-04 3.410 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.989020e-04 3.399 0 0
ESR-mediated signaling R-HSA-8939211 4.300212e-04 3.367 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.826340e-04 3.316 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.920632e-04 3.308 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.081045e-04 3.294 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.081045e-04 3.294 0 0
Mitotic Prometaphase R-HSA-68877 5.263805e-04 3.279 0 0
mRNA Splicing R-HSA-72172 5.407622e-04 3.267 0 0
Semaphorin interactions R-HSA-373755 6.633093e-04 3.178 0 0
RET signaling R-HSA-8853659 7.634764e-04 3.117 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.327856e-04 3.079 0 0
Separation of Sister Chromatids R-HSA-2467813 8.547922e-04 3.068 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.187667e-04 3.037 0 0
RNA Polymerase II Transcription R-HSA-73857 9.299598e-04 3.032 0 0
Activation of RAC1 R-HSA-428540 9.903657e-04 3.004 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.077072e-03 2.968 0 0
Signaling by ROBO receptors R-HSA-376176 1.326247e-03 2.877 0 0
Metalloprotease DUBs R-HSA-5689901 1.363589e-03 2.865 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.579580e-03 2.801 0 0
Gene expression (Transcription) R-HSA-74160 1.743539e-03 2.759 0 0
RMTs methylate histone arginines R-HSA-3214858 1.859598e-03 2.731 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.910310e-03 2.719 0 0
Adherens junctions interactions R-HSA-418990 1.851268e-03 2.733 0 0
Base Excision Repair R-HSA-73884 1.933567e-03 2.714 0 0
Developmental Biology R-HSA-1266738 2.092300e-03 2.679 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.097742e-03 2.678 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.122166e-03 2.673 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.122166e-03 2.673 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.201220e-03 2.657 0 0
Integrin signaling R-HSA-354192 2.442835e-03 2.612 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.510242e-03 2.600 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.656787e-03 2.576 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.075610e-03 2.512 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.075610e-03 2.512 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.206104e-03 2.494 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.505561e-03 2.455 0 0
MAPK family signaling cascades R-HSA-5683057 3.729858e-03 2.428 0 0
TRP channels R-HSA-3295583 4.048888e-03 2.393 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.145201e-03 2.382 0 0
Signaling by WNT R-HSA-195721 4.262116e-03 2.370 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.539555e-03 2.343 0 0
Deubiquitination R-HSA-5688426 4.641112e-03 2.333 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.682757e-03 2.329 0 0
Interleukin-12 signaling R-HSA-9020591 4.713884e-03 2.327 0 0
Muscle contraction R-HSA-397014 4.883147e-03 2.311 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.444809e-03 2.264 0 0
Post NMDA receptor activation events R-HSA-438064 5.280291e-03 2.277 0 0
Generic Transcription Pathway R-HSA-212436 5.004269e-03 2.301 0 0
DNA Replication R-HSA-69306 4.903645e-03 2.309 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.059381e-03 2.296 0 0
Cell-cell junction organization R-HSA-421270 5.429428e-03 2.265 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.607948e-03 2.251 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.607948e-03 2.251 0 0
Ub-specific processing proteases R-HSA-5689880 6.209259e-03 2.207 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.470379e-03 2.189 0 0
FOXO-mediated transcription R-HSA-9614085 7.091950e-03 2.149 0 0
Neurodegenerative Diseases R-HSA-8863678 7.313110e-03 2.136 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 7.313110e-03 2.136 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.601960e-03 2.119 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.775050e-03 2.109 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.806520e-03 2.108 0 0
DNA Repair R-HSA-73894 7.871764e-03 2.104 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.013625e-03 2.096 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.059367e-03 2.094 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 8.132411e-03 2.090 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 8.613947e-03 2.065 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 8.613947e-03 2.065 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 8.613947e-03 2.065 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 8.613947e-03 2.065 0 0
HDMs demethylate histones R-HSA-3214842 9.054353e-03 2.043 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 9.207712e-03 2.036 0 0
snRNP Assembly R-HSA-191859 8.944071e-03 2.048 0 0
Metabolism of non-coding RNA R-HSA-194441 8.944071e-03 2.048 0 0
HCMV Early Events R-HSA-9609690 8.713452e-03 2.060 0 0
Signaling by NOTCH R-HSA-157118 9.237892e-03 2.034 0 0
Activation of BH3-only proteins R-HSA-114452 9.321493e-03 2.031 0 0
Specification of primordial germ cells R-HSA-9827857 9.636610e-03 2.016 0 0
Kinesins R-HSA-983189 1.022018e-02 1.991 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.061012e-02 1.974 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.083914e-02 1.965 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.107655e-02 1.956 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.107655e-02 1.956 0 0
HCMV Late Events R-HSA-9610379 1.129254e-02 1.947 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.138458e-02 1.944 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.139429e-02 1.943 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.177582e-02 1.929 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.211401e-02 1.917 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.229851e-02 1.910 0 0
Ephrin signaling R-HSA-3928664 1.229851e-02 1.910 0 0
FLT3 Signaling R-HSA-9607240 1.268661e-02 1.897 0 0
Calmodulin induced events R-HSA-111933 1.313778e-02 1.881 0 0
CaM pathway R-HSA-111997 1.313778e-02 1.881 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.441517e-02 1.841 0 0
DCC mediated attractive signaling R-HSA-418885 1.400522e-02 1.854 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.402445e-02 1.853 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.402445e-02 1.853 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.402445e-02 1.853 0 0
Signaling by RAS mutants R-HSA-6802949 1.402445e-02 1.853 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.532091e-02 1.815 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.542395e-02 1.812 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.605703e-02 1.794 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.605703e-02 1.794 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.605703e-02 1.794 0 0
Type I hemidesmosome assembly R-HSA-446107 1.605703e-02 1.794 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.605703e-02 1.794 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.636941e-02 1.786 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.710070e-02 1.767 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.797139e-02 1.745 0 0
Interleukin-12 family signaling R-HSA-447115 1.849015e-02 1.733 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.901611e-02 1.721 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.918044e-02 1.717 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 2.045034e-02 1.689 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.088350e-02 1.680 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.088350e-02 1.680 0 0
Nuclear import of Rev protein R-HSA-180746 2.197097e-02 1.658 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.207872e-02 1.656 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.222529e-02 1.653 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.222529e-02 1.653 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.222529e-02 1.653 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.222529e-02 1.653 0 0
Signaling by MAPK mutants R-HSA-9652817 2.222529e-02 1.653 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.287292e-02 1.641 0 0
Signaling by EGFR R-HSA-177929 2.498537e-02 1.602 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.496788e-02 1.603 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.577714e-02 1.589 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.234036e-02 1.651 0 0
DAG and IP3 signaling R-HSA-1489509 2.577714e-02 1.589 0 0
PLC beta mediated events R-HSA-112043 2.302007e-02 1.638 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.409734e-02 1.618 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.222529e-02 1.653 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.643157e-02 1.578 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.686561e-02 1.571 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.686561e-02 1.571 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.790210e-02 1.554 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.814764e-02 1.551 0 0
Metabolism of RNA R-HSA-8953854 2.816495e-02 1.550 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.845598e-02 1.546 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.900587e-02 1.538 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.900587e-02 1.538 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.900587e-02 1.538 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.900587e-02 1.538 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.900587e-02 1.538 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.900587e-02 1.538 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.916303e-02 1.535 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.953801e-02 1.530 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.003112e-02 1.522 0 0
Regulation of CDH11 function R-HSA-9762292 3.003112e-02 1.522 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.141536e-02 1.503 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.159009e-02 1.500 0 0
MAP2K and MAPK activation R-HSA-5674135 3.159009e-02 1.500 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.219232e-02 1.492 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.219232e-02 1.492 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.394980e-02 1.469 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.397897e-02 1.469 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.407501e-02 1.468 0 0
mTORC1-mediated signalling R-HSA-166208 3.407501e-02 1.468 0 0
Opioid Signalling R-HSA-111885 3.439453e-02 1.464 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.446183e-02 1.463 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.165070e-02 1.380 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.629746e-02 1.440 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.629746e-02 1.440 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.590526e-02 1.445 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.162266e-02 1.381 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.629746e-02 1.440 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.629746e-02 1.440 0 0
MTOR signalling R-HSA-165159 3.590526e-02 1.445 0 0
PECAM1 interactions R-HSA-210990 3.920655e-02 1.407 0 0
Ca-dependent events R-HSA-111996 3.590526e-02 1.445 0 0
Co-stimulation by CD28 R-HSA-389356 3.732507e-02 1.428 0 0
Signaling by NTRKs R-HSA-166520 3.599119e-02 1.444 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.162266e-02 1.381 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.178316e-02 1.379 0 0
Glycolysis R-HSA-70171 4.101079e-02 1.387 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.880726e-02 1.411 0 0
G-protein mediated events R-HSA-112040 4.336083e-02 1.363 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.375906e-02 1.359 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.412842e-02 1.355 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.439320e-02 1.353 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.439320e-02 1.353 0 0
DARPP-32 events R-HSA-180024 4.473614e-02 1.349 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.667086e-02 1.331 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.744199e-02 1.324 0 0
Potassium Channels R-HSA-1296071 4.887988e-02 1.311 0 0
HCMV Infection R-HSA-9609646 4.893081e-02 1.310 0 0
Formation of definitive endoderm R-HSA-9823730 4.974694e-02 1.303 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.991548e-02 1.302 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.991548e-02 1.302 0 0
Stimuli-sensing channels R-HSA-2672351 5.050637e-02 1.297 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.092428e-02 1.293 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.092428e-02 1.293 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.439230e-02 1.264 0 0
Long-term potentiation R-HSA-9620244 5.533468e-02 1.257 0 0
Formation of the nephric duct R-HSA-9830364 5.533468e-02 1.257 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.563119e-02 1.255 1 0
Cardiac conduction R-HSA-5576891 5.570148e-02 1.254 0 0
Signaling by TGFBR3 R-HSA-9839373 5.732536e-02 1.242 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.786995e-02 1.238 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.860943e-02 1.232 0 0
Adrenoceptors R-HSA-390696 5.883909e-02 1.230 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.883909e-02 1.230 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 5.994234e-02 1.222 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 5.994234e-02 1.222 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 5.994234e-02 1.222 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 5.994234e-02 1.222 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 6.217849e-02 1.206 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 6.217849e-02 1.206 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 6.217849e-02 1.206 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 6.217849e-02 1.206 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 6.217849e-02 1.206 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.302498e-02 1.200 0 0
Myogenesis R-HSA-525793 6.395427e-02 1.194 0 0
L1CAM interactions R-HSA-373760 6.492134e-02 1.188 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.604840e-02 1.180 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.604840e-02 1.180 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.604840e-02 1.180 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.604840e-02 1.180 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.604840e-02 1.180 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.727668e-02 1.172 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.727668e-02 1.172 0 0
Signaling by Interleukins R-HSA-449147 6.772374e-02 1.169 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.548286e-02 1.122 0 0
WNT mediated activation of DVL R-HSA-201688 7.548286e-02 1.122 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.548286e-02 1.122 0 0
ALK mutants bind TKIs R-HSA-9700645 7.548286e-02 1.122 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.874753e-02 1.163 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.336328e-02 1.135 0 0
Striated Muscle Contraction R-HSA-390522 8.566104e-02 1.067 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.967175e-02 1.099 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.548286e-02 1.122 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.548286e-02 1.122 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.612882e-02 1.118 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.598904e-02 1.119 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.865178e-02 1.104 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.624521e-02 1.118 1 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.360501e-02 1.133 0 0
Signaling by ALK in cancer R-HSA-9700206 7.360501e-02 1.133 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.589160e-02 1.066 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.928315e-02 1.159 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.336328e-02 1.135 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.274944e-02 1.138 0 0
Maturation of nucleoprotein R-HSA-9683610 7.598904e-02 1.119 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.652934e-02 1.063 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.898748e-02 1.051 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 8.982089e-02 1.047 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 8.982089e-02 1.047 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 8.982089e-02 1.047 0 0
Regulation of KIT signaling R-HSA-1433559 9.131537e-02 1.039 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.131537e-02 1.039 0 0
Removal of the Flap Intermediate R-HSA-69166 9.131537e-02 1.039 0 0
Signal regulatory protein family interactions R-HSA-391160 9.131537e-02 1.039 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.154307e-02 1.038 0 0
Signaling by NOTCH1 R-HSA-1980143 9.380031e-02 1.028 0 0
UCH proteinases R-HSA-5689603 9.380031e-02 1.028 0 0
Receptor Mediated Mitophagy R-HSA-8934903 9.422786e-02 1.026 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 9.422786e-02 1.026 0 0
Signaling by Leptin R-HSA-2586552 9.422786e-02 1.026 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.456084e-02 1.024 0 0
RAF activation R-HSA-5673000 9.587301e-02 1.018 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.587301e-02 1.018 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.587301e-02 1.018 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.604418e-02 1.018 0 0
Regulation of TP53 Expression R-HSA-6804754 9.797404e-02 1.009 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 9.797404e-02 1.009 0 0
Potassium transport channels R-HSA-1296067 9.797404e-02 1.009 0 0
IGF1R signaling cascade R-HSA-2428924 9.872673e-02 1.006 0 0
Specification of the neural plate border R-HSA-9834899 9.988148e-02 1.001 0 0
The NLRP3 inflammasome R-HSA-844456 9.988148e-02 1.001 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.026319e-01 0.989 0 0
Deadenylation of mRNA R-HSA-429947 1.043486e-01 0.982 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.230857e-01 0.910 0 0
KIT mutants bind TKIs R-HSA-9669921 1.230857e-01 0.910 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.230857e-01 0.910 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.230857e-01 0.910 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.230857e-01 0.910 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.230857e-01 0.910 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.230857e-01 0.910 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.230857e-01 0.910 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.230857e-01 0.910 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.230857e-01 0.910 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.230857e-01 0.910 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.230857e-01 0.910 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.408873e-01 0.851 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.408873e-01 0.851 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.408873e-01 0.851 0 0
Axonal growth stimulation R-HSA-209563 1.408873e-01 0.851 0 0
MET activates PTPN11 R-HSA-8865999 1.408873e-01 0.851 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.408873e-01 0.851 0 0
CREB phosphorylation R-HSA-199920 1.166007e-01 0.933 0 0
Signaling by APC mutants R-HSA-4839744 1.149370e-01 0.940 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.149370e-01 0.940 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.149370e-01 0.940 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.149370e-01 0.940 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.081029e-01 0.966 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.081029e-01 0.966 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.081029e-01 0.966 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.149937e-01 0.939 0 0
Activation of the pre-replicative complex R-HSA-68962 1.063394e-01 0.973 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.063394e-01 0.973 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.326680e-01 0.877 0 0
Trafficking of AMPA receptors R-HSA-399719 1.188877e-01 0.925 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.154381e-01 0.938 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.086258e-01 0.964 0 0
Signaling by FGFR4 R-HSA-5654743 1.399494e-01 0.854 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.081029e-01 0.966 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.311829e-01 0.882 0 0
G0 and Early G1 R-HSA-1538133 1.321858e-01 0.879 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.068860e-01 0.971 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.204317e-01 0.919 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.247943e-01 0.904 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.067599e-01 0.972 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.188200e-01 0.925 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.188200e-01 0.925 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.188200e-01 0.925 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.188200e-01 0.925 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.247943e-01 0.904 1 1
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.408873e-01 0.851 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.180667e-01 0.928 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.081029e-01 0.966 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.374419e-01 0.862 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.380741e-01 0.860 0 0
Adaptive Immune System R-HSA-1280218 1.403954e-01 0.853 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.383176e-01 0.859 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.374419e-01 0.862 0 0
Signaling by AXIN mutants R-HSA-4839735 1.374419e-01 0.862 0 0
TGFBR3 expression R-HSA-9839394 1.180667e-01 0.928 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.188200e-01 0.925 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.281147e-01 0.892 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.383113e-01 0.859 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.061512e-01 0.974 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.353119e-01 0.869 0 0
Interleukin-37 signaling R-HSA-9008059 1.063394e-01 0.973 0 0
Co-inhibition by PD-1 R-HSA-389948 1.414532e-01 0.849 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.420611e-01 0.848 0 0
Ion homeostasis R-HSA-5578775 1.429934e-01 0.845 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.429934e-01 0.845 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.457462e-01 0.836 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.457462e-01 0.836 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 1.457462e-01 0.836 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.459396e-01 0.836 0 0
Netrin mediated repulsion signals R-HSA-418886 1.459396e-01 0.836 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.459396e-01 0.836 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.459396e-01 0.836 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.459396e-01 0.836 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.462085e-01 0.835 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.462085e-01 0.835 0 0
G-protein beta:gamma signalling R-HSA-397795 1.462085e-01 0.835 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.462085e-01 0.835 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.462085e-01 0.835 0 0
Neuronal System R-HSA-112316 1.475095e-01 0.831 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.475569e-01 0.831 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.475569e-01 0.831 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.481155e-01 0.829 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.481155e-01 0.829 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.483927e-01 0.829 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.483927e-01 0.829 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.487211e-01 0.828 0 0
Glucose metabolism R-HSA-70326 1.494230e-01 0.826 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.534980e-01 0.814 0 0
S Phase R-HSA-69242 1.557048e-01 0.808 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.310277e-01 0.636 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.310277e-01 0.636 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.310277e-01 0.636 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.310277e-01 0.636 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.310277e-01 0.636 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.310277e-01 0.636 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.310277e-01 0.636 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.310277e-01 0.636 0 0
Regulation of gap junction activity R-HSA-191650 1.869054e-01 0.728 0 0
TNFR1-mediated ceramide production R-HSA-5626978 1.869054e-01 0.728 0 0
NADE modulates death signalling R-HSA-205025 1.869054e-01 0.728 0 0
HCN channels R-HSA-1296061 1.869054e-01 0.728 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.869054e-01 0.728 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.869054e-01 0.728 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.869054e-01 0.728 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.869054e-01 0.728 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.869054e-01 0.728 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.869054e-01 0.728 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.869054e-01 0.728 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.256882e-01 0.487 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.256882e-01 0.487 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.256882e-01 0.487 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.256882e-01 0.487 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.256882e-01 0.487 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.256882e-01 0.487 0 0
MPS IIID - Sanfilippo syndrome D R-HSA-2206305 3.256882e-01 0.487 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.256882e-01 0.487 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.256882e-01 0.487 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.256882e-01 0.487 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 3.256882e-01 0.487 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.256882e-01 0.487 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.256882e-01 0.487 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.256882e-01 0.487 0 0
Intestinal infectious diseases R-HSA-8942233 3.256882e-01 0.487 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.256882e-01 0.487 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.346148e-01 0.630 0 0
IRS activation R-HSA-74713 2.346148e-01 0.630 0 0
G2 Phase R-HSA-68911 2.346148e-01 0.630 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 1.773737e-01 0.751 0 0
FGFR1b ligand binding and activation R-HSA-190370 1.773737e-01 0.751 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.773737e-01 0.751 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.773737e-01 0.751 0 0
Polymerase switching R-HSA-69091 1.615509e-01 0.792 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.615509e-01 0.792 0 0
Leading Strand Synthesis R-HSA-69109 1.615509e-01 0.792 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.829026e-01 0.548 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.829026e-01 0.548 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.087008e-01 0.389 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.087008e-01 0.389 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.087008e-01 0.389 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.087008e-01 0.389 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.087008e-01 0.389 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.087008e-01 0.389 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.087008e-01 0.389 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.087008e-01 0.389 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.087008e-01 0.389 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.087008e-01 0.389 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.087008e-01 0.389 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.087008e-01 0.389 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.087008e-01 0.389 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.087008e-01 0.389 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.087008e-01 0.389 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.087008e-01 0.389 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.087008e-01 0.389 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.870573e-01 0.728 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.870573e-01 0.728 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.447124e-01 0.611 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.447124e-01 0.611 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 1.664049e-01 0.779 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.309041e-01 0.480 0 0
STAT5 Activation R-HSA-9645135 3.309041e-01 0.480 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.309041e-01 0.480 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.309041e-01 0.480 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.881365e-01 0.726 0 0
GAB1 signalosome R-HSA-180292 1.881365e-01 0.726 0 0
PKA activation in glucagon signalling R-HSA-164378 1.881365e-01 0.726 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.797676e-01 0.553 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.797676e-01 0.553 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.413982e-01 0.617 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 2.108166e-01 0.676 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.108166e-01 0.676 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.643655e-01 0.784 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.609256e-01 0.793 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.813684e-01 0.741 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.813684e-01 0.741 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.054515e-01 0.687 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 2.343156e-01 0.630 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.343156e-01 0.630 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.343156e-01 0.630 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.343156e-01 0.630 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.343156e-01 0.630 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.152354e-01 0.501 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.152354e-01 0.501 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.779584e-01 0.423 0 0
SOS-mediated signalling R-HSA-112412 3.779584e-01 0.423 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.779584e-01 0.423 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.779584e-01 0.423 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.779584e-01 0.423 0 0
Disinhibition of SNARE formation R-HSA-114516 3.779584e-01 0.423 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.763020e-01 0.754 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.763020e-01 0.754 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.990696e-01 0.701 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.585010e-01 0.588 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.507796e-01 0.455 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.507796e-01 0.455 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.507796e-01 0.455 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.507796e-01 0.455 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.507796e-01 0.455 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.507796e-01 0.455 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.832400e-01 0.548 0 0
Voltage gated Potassium channels R-HSA-1296072 2.259803e-01 0.646 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.689380e-01 0.570 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.689380e-01 0.570 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.689380e-01 0.570 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.689380e-01 0.570 0 0
RSK activation R-HSA-444257 4.235715e-01 0.373 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.235715e-01 0.373 0 0
Formation of annular gap junctions R-HSA-196025 4.235715e-01 0.373 0 0
Activation of RAS in B cells R-HSA-1169092 4.235715e-01 0.373 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 3.084011e-01 0.511 0 0
Notch-HLH transcription pathway R-HSA-350054 3.084011e-01 0.511 0 0
Translation initiation complex formation R-HSA-72649 1.982103e-01 0.703 0 0
HIV elongation arrest and recovery R-HSA-167287 2.911131e-01 0.536 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.911131e-01 0.536 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.861041e-01 0.413 0 0
Formation of axial mesoderm R-HSA-9796292 3.861041e-01 0.413 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.574461e-01 0.447 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.858921e-01 0.731 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.338565e-01 0.476 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.136420e-01 0.504 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.958790e-01 0.529 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.292571e-01 0.640 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.292571e-01 0.640 0 0
Centrosome maturation R-HSA-380287 2.091670e-01 0.680 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.835144e-01 0.736 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.684105e-01 0.571 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.164374e-01 0.500 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.164374e-01 0.500 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.364341e-01 0.473 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.594826e-01 0.444 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.868515e-01 0.412 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.868515e-01 0.412 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.209525e-01 0.376 0 0
cGMP effects R-HSA-418457 4.209525e-01 0.376 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.673854e-01 0.330 0 0
Lipophagy R-HSA-9613354 4.673854e-01 0.330 0 0
Gap junction degradation R-HSA-190873 4.673854e-01 0.330 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.846151e-01 0.546 0 0
G1/S-Specific Transcription R-HSA-69205 3.372359e-01 0.472 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 3.851621e-01 0.414 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.851621e-01 0.414 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.160738e-01 0.381 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.012190e-01 0.521 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.551066e-01 0.342 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.346870e-01 0.475 0 0
Cellular response to heat stress R-HSA-3371556 2.474192e-01 0.607 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 4.449688e-01 0.352 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.449688e-01 0.352 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.004094e-01 0.397 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.362466e-01 0.360 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.226198e-01 0.491 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.180950e-01 0.497 0 0
HIV Transcription Elongation R-HSA-167169 4.215145e-01 0.375 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.215145e-01 0.375 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.215145e-01 0.375 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.865183e-01 0.543 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 4.734084e-01 0.325 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.734084e-01 0.325 0 0
Signaling by FGFR2 R-HSA-5654738 3.734965e-01 0.428 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.983285e-01 0.400 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.634402e-01 0.334 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.417515e-01 0.355 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.022280e-01 0.520 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.597524e-01 0.585 0 0
RUNX2 regulates bone development R-HSA-8941326 3.372359e-01 0.472 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.911131e-01 0.536 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.923972e-01 0.534 0 0
Signaling by FGFR3 R-HSA-5654741 1.652467e-01 0.782 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.079268e-01 0.512 0 0
Hedgehog 'off' state R-HSA-5610787 2.956322e-01 0.529 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.557556e-01 0.592 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.881365e-01 0.726 0 0
Recycling pathway of L1 R-HSA-437239 1.925775e-01 0.715 0 0
p75NTR signals via NF-kB R-HSA-193639 2.413982e-01 0.617 0 0
Signaling by SCF-KIT R-HSA-1433557 3.563813e-01 0.448 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.881365e-01 0.726 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.610711e-01 0.793 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.012190e-01 0.521 0 0
Lagging Strand Synthesis R-HSA-69186 2.585010e-01 0.588 0 0
G1/S Transition R-HSA-69206 3.002764e-01 0.522 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.280170e-01 0.484 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.160738e-01 0.381 0 0
Telomere Extension By Telomerase R-HSA-171319 4.614538e-01 0.336 0 0
Signaling by FGFR1 R-HSA-5654736 2.259921e-01 0.646 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.615509e-01 0.792 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.987386e-01 0.525 0 0
IRS-mediated signalling R-HSA-112399 3.517443e-01 0.454 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.272701e-01 0.369 0 0
Insulin receptor signalling cascade R-HSA-74751 3.491703e-01 0.457 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.292571e-01 0.640 0 0
p75NTR regulates axonogenesis R-HSA-193697 2.104443e-01 0.677 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.372359e-01 0.472 0 0
Signaling by ERBB2 R-HSA-1227986 1.899548e-01 0.721 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.656323e-01 0.576 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.360537e-01 0.474 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.360537e-01 0.474 0 0
Developmental Cell Lineages R-HSA-9734767 4.030773e-01 0.395 0 0
Signal attenuation R-HSA-74749 2.447124e-01 0.611 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.922988e-01 0.716 0 0
Prolactin receptor signaling R-HSA-1170546 4.209525e-01 0.376 0 0
Extension of Telomeres R-HSA-180786 3.861938e-01 0.413 0 0
Frs2-mediated activation R-HSA-170968 3.861041e-01 0.413 0 0
MHC class II antigen presentation R-HSA-2132295 2.681042e-01 0.572 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.689380e-01 0.570 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.773737e-01 0.751 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.152354e-01 0.501 0 0
PI3K Cascade R-HSA-109704 2.369404e-01 0.625 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.552027e-01 0.593 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.634402e-01 0.334 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.932334e-01 0.405 0 0
G alpha (s) signalling events R-HSA-418555 4.434760e-01 0.353 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.869054e-01 0.728 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.829026e-01 0.548 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.664049e-01 0.779 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.697990e-01 0.569 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.779584e-01 0.423 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.763020e-01 0.754 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.472083e-01 0.607 0 0
DNA strand elongation R-HSA-69190 2.363269e-01 0.626 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.435709e-01 0.613 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 4.551066e-01 0.342 0 0
Signalling to RAS R-HSA-167044 4.449688e-01 0.352 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.285138e-01 0.368 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.861938e-01 0.413 0 0
Peptide chain elongation R-HSA-156902 3.983285e-01 0.400 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 4.089318e-01 0.388 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.860696e-01 0.544 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.619980e-01 0.441 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.217421e-01 0.654 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.868515e-01 0.412 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.756290e-01 0.560 0 0
Mismatch Repair R-HSA-5358508 3.574461e-01 0.447 0 0
Dopamine receptors R-HSA-390651 1.869054e-01 0.728 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.346148e-01 0.630 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.104443e-01 0.677 0 0
PKA activation R-HSA-163615 1.881365e-01 0.726 0 0
Telomere C-strand synthesis initiation R-HSA-174430 2.413982e-01 0.617 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.108166e-01 0.676 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.779584e-01 0.423 0 0
Passive transport by Aquaporins R-HSA-432047 2.987386e-01 0.525 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.557556e-01 0.592 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.476153e-01 0.349 0 0
Interleukin-2 signaling R-HSA-9020558 2.797676e-01 0.553 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.084011e-01 0.511 0 0
Neurexins and neuroligins R-HSA-6794361 2.684105e-01 0.571 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.514832e-01 0.454 0 0
Repression of WNT target genes R-HSA-4641265 1.615509e-01 0.792 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.005721e-01 0.698 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.514832e-01 0.454 0 0
GPER1 signaling R-HSA-9634597 2.069445e-01 0.684 0 0
TNF signaling R-HSA-75893 3.346870e-01 0.475 0 0
Signaling by WNT in cancer R-HSA-4791275 2.363269e-01 0.626 0 0
Signalling to ERKs R-HSA-187687 3.164374e-01 0.500 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.326557e-01 0.478 0 0
Calcineurin activates NFAT R-HSA-2025928 2.104443e-01 0.677 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.829026e-01 0.548 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.870573e-01 0.728 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.137458e-01 0.670 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.152354e-01 0.501 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.990696e-01 0.701 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.260159e-01 0.646 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.235715e-01 0.373 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.235715e-01 0.373 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.235715e-01 0.373 0 0
FGFR1c ligand binding and activation R-HSA-190373 3.861041e-01 0.413 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.958790e-01 0.529 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.472656e-01 0.607 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.374475e-01 0.624 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.551066e-01 0.342 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.843318e-01 0.546 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.513627e-01 0.345 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.887636e-01 0.410 0 0
Signaling by Hedgehog R-HSA-5358351 4.728305e-01 0.325 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.907484e-01 0.408 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.472083e-01 0.607 0 0
Cyclin D associated events in G1 R-HSA-69231 3.759000e-01 0.425 0 0
G1 Phase R-HSA-69236 3.759000e-01 0.425 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.327670e-01 0.364 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.987386e-01 0.525 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.756290e-01 0.560 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.971596e-01 0.401 0 0
Aquaporin-mediated transport R-HSA-445717 4.208562e-01 0.376 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.987386e-01 0.525 0 0
Transmission across Chemical Synapses R-HSA-112315 4.634811e-01 0.334 0 0
Membrane Trafficking R-HSA-199991 2.662786e-01 0.575 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.870573e-01 0.728 0 0
Platelet calcium homeostasis R-HSA-418360 3.136420e-01 0.504 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.997121e-01 0.700 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.164374e-01 0.500 0 0
G2/M Transition R-HSA-69275 3.004909e-01 0.522 0 0
Signaling by LTK R-HSA-9842663 1.615509e-01 0.792 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.104443e-01 0.677 0 0
Formation of intermediate mesoderm R-HSA-9761174 2.447124e-01 0.611 0 0
Polo-like kinase mediated events R-HSA-156711 1.881365e-01 0.726 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.697990e-01 0.569 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.235715e-01 0.373 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.557556e-01 0.592 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.856253e-01 0.544 0 0
p38MAPK events R-HSA-171007 4.551066e-01 0.342 0 0
Degradation of CDH1 R-HSA-9766229 4.735085e-01 0.325 0 0
Cardiogenesis R-HSA-9733709 2.557556e-01 0.592 0 0
Oncogene Induced Senescence R-HSA-2559585 1.922988e-01 0.716 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.619980e-01 0.441 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.425433e-01 0.354 0 0
Interleukin-2 family signaling R-HSA-451927 4.215145e-01 0.375 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.756290e-01 0.560 0 0
Rab regulation of trafficking R-HSA-9007101 4.558648e-01 0.341 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.584114e-01 0.588 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.954842e-01 0.403 0 0
HIV Life Cycle R-HSA-162587 2.256543e-01 0.647 0 0
DNA Damage Bypass R-HSA-73893 4.735085e-01 0.325 0 0
HIV Infection R-HSA-162906 2.872873e-01 0.542 0 0
NGF-stimulated transcription R-HSA-9031628 2.069445e-01 0.684 0 0
Inhibition of PKR R-HSA-169131 2.310277e-01 0.636 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.869054e-01 0.728 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.256882e-01 0.487 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.256882e-01 0.487 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.104443e-01 0.677 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.829026e-01 0.548 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.087008e-01 0.389 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.870573e-01 0.728 0 0
Bicarbonate transporters R-HSA-425381 2.797676e-01 0.553 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.813684e-01 0.741 0 0
Negative regulation of FLT3 R-HSA-9706369 2.697990e-01 0.569 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.779584e-01 0.423 0 0
Disorders of Developmental Biology R-HSA-9675151 2.987386e-01 0.525 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.652467e-01 0.782 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.832400e-01 0.548 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.235715e-01 0.373 0 0
Diseases of Immune System R-HSA-5260271 2.800012e-01 0.553 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.800012e-01 0.553 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.594826e-01 0.444 0 0
Unwinding of DNA R-HSA-176974 4.673854e-01 0.330 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.012190e-01 0.521 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.551066e-01 0.342 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.879327e-01 0.411 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.879327e-01 0.411 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.248334e-01 0.372 0 0
Signaling by ERBB4 R-HSA-1236394 2.860860e-01 0.544 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.715314e-01 0.566 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.430329e-01 0.614 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.472083e-01 0.607 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.248334e-01 0.372 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.715314e-01 0.566 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.800012e-01 0.553 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.003415e-01 0.522 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.715314e-01 0.566 0 0
Host Interactions of HIV factors R-HSA-162909 2.786847e-01 0.555 0 0
Cellular responses to stress R-HSA-2262752 2.105775e-01 0.677 0 0
Cellular responses to stimuli R-HSA-8953897 1.700423e-01 0.769 1 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.557556e-01 0.592 0 0
Amine ligand-binding receptors R-HSA-375280 3.759000e-01 0.425 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.706397e-01 0.327 0 0
Smooth Muscle Contraction R-HSA-445355 1.849173e-01 0.733 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.104443e-01 0.677 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.235715e-01 0.373 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.673854e-01 0.330 0 0
TBC/RABGAPs R-HSA-8854214 3.563813e-01 0.448 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 4.147016e-01 0.382 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.734084e-01 0.325 0 0
Pyroptosis R-HSA-5620971 1.643655e-01 0.784 0 0
Interleukin-1 processing R-HSA-448706 2.104443e-01 0.677 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.870573e-01 0.728 0 0
Nef and signal transduction R-HSA-164944 3.309041e-01 0.480 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.507796e-01 0.455 0 0
Disorders of Nervous System Development R-HSA-9697154 3.507796e-01 0.455 0 0
Pervasive developmental disorders R-HSA-9005895 3.507796e-01 0.455 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.235715e-01 0.373 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.673854e-01 0.330 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.673854e-01 0.330 0 0
Protein hydroxylation R-HSA-9629569 4.160738e-01 0.381 0 0
Heme signaling R-HSA-9707616 4.381821e-01 0.358 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.090065e-01 0.510 0 0
Sensory processing of sound R-HSA-9659379 3.586033e-01 0.445 0 0
Diseases of DNA repair R-HSA-9675135 1.786695e-01 0.748 0 0
Ion channel transport R-HSA-983712 3.985971e-01 0.399 0 0
Downstream signal transduction R-HSA-186763 3.594011e-01 0.444 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.330219e-01 0.478 0 0
PI Metabolism R-HSA-1483255 3.203656e-01 0.494 0 0
Signal transduction by L1 R-HSA-445144 4.160738e-01 0.381 0 0
Inflammasomes R-HSA-622312 2.911131e-01 0.536 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.429532e-01 0.465 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.259921e-01 0.646 0 0
Signaling by NOTCH3 R-HSA-9012852 3.177891e-01 0.498 0 0
Protein ubiquitination R-HSA-8852135 2.091670e-01 0.680 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.256882e-01 0.487 0 0
DSCAM interactions R-HSA-376172 4.087008e-01 0.389 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.447124e-01 0.611 0 0
Synthesis of PI R-HSA-1483226 2.797676e-01 0.553 0 0
Formation of the anterior neural plate R-HSA-9823739 2.413982e-01 0.617 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 3.084011e-01 0.511 0 0
Platelet sensitization by LDL R-HSA-432142 3.574461e-01 0.447 0 0
Syndecan interactions R-HSA-3000170 3.338565e-01 0.476 0 0
Physiological factors R-HSA-5578768 4.209525e-01 0.376 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.673854e-01 0.330 0 0
ARMS-mediated activation R-HSA-170984 4.673854e-01 0.330 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.792867e-01 0.421 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.150843e-01 0.382 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.274718e-01 0.369 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.364341e-01 0.473 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.338565e-01 0.476 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.492220e-01 0.348 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.393335e-01 0.621 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.824574e-01 0.417 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.585010e-01 0.588 0 0
Signaling by TGFB family members R-HSA-9006936 3.954504e-01 0.403 0 0
Signaling by ALK R-HSA-201556 2.615952e-01 0.582 0 0
tRNA processing in the nucleus R-HSA-6784531 3.170280e-01 0.499 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.055209e-01 0.392 0 0
Plasma lipoprotein assembly R-HSA-8963898 3.594826e-01 0.444 0 0
NrCAM interactions R-HSA-447038 2.346148e-01 0.630 0 0
Co-inhibition by BTLA R-HSA-9927353 2.346148e-01 0.630 0 0
Sodium/Proton exchangers R-HSA-425986 1.773737e-01 0.751 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.779584e-01 0.423 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.166968e-01 0.664 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.715532e-01 0.326 0 0
Zinc transporters R-HSA-435354 4.209525e-01 0.376 0 0
Inositol phosphate metabolism R-HSA-1483249 2.812620e-01 0.551 0 0
HDL assembly R-HSA-8963896 2.137458e-01 0.670 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.137458e-01 0.670 0 0
Maturation of nucleoprotein R-HSA-9694631 2.108166e-01 0.676 0 0
Metal ion SLC transporters R-HSA-425410 4.541414e-01 0.343 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.108166e-01 0.676 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 2.829026e-01 0.548 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 2.829026e-01 0.548 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.413982e-01 0.617 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.786695e-01 0.748 0 0
Influenza Infection R-HSA-168255 3.729606e-01 0.428 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.481718e-01 0.605 0 0
Growth hormone receptor signaling R-HSA-982772 1.856037e-01 0.731 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.861041e-01 0.413 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.313501e-01 0.365 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.667816e-01 0.574 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.814983e-01 0.317 0 0
Classical Kir channels R-HSA-1296053 4.814983e-01 0.317 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.814983e-01 0.317 0 0
Invadopodia formation R-HSA-8941237 4.814983e-01 0.317 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.814983e-01 0.317 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.814983e-01 0.317 0 0
MET interacts with TNS proteins R-HSA-8875513 4.814983e-01 0.317 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.814983e-01 0.317 0 0
Histamine receptors R-HSA-390650 4.814983e-01 0.317 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.814983e-01 0.317 0 0
Signaling by Erythropoietin R-HSA-9006335 4.863194e-01 0.313 0 0
Late endosomal microautophagy R-HSA-9615710 4.863194e-01 0.313 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.863194e-01 0.313 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.863194e-01 0.313 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 4.883845e-01 0.311 0 0
Phosphorylation of the APC/C R-HSA-176412 4.883845e-01 0.311 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.883845e-01 0.311 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 4.883845e-01 0.311 0 0
Prolonged ERK activation events R-HSA-169893 4.883845e-01 0.311 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.883845e-01 0.311 0 0
Killing mechanisms R-HSA-9664420 4.883845e-01 0.311 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 4.883845e-01 0.311 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.883845e-01 0.311 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.927118e-01 0.307 0 0
Ca2+ pathway R-HSA-4086398 4.965422e-01 0.304 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 5.012801e-01 0.300 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.012801e-01 0.300 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.075810e-01 0.294 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.091518e-01 0.293 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.091518e-01 0.293 0 0
DNA replication initiation R-HSA-68952 5.091518e-01 0.293 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.091518e-01 0.293 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.091518e-01 0.293 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.091518e-01 0.293 0 0
PI3K/AKT activation R-HSA-198203 5.091518e-01 0.293 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.091518e-01 0.293 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.091518e-01 0.293 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.096677e-01 0.293 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.107657e-01 0.292 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.107657e-01 0.292 0 0
HSF1-dependent transactivation R-HSA-3371571 5.117122e-01 0.291 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.119311e-01 0.291 0 0
Signaling by FGFR in disease R-HSA-1226099 5.126301e-01 0.290 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.135136e-01 0.289 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.143589e-01 0.289 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.183500e-01 0.285 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.183877e-01 0.285 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.206381e-01 0.283 0 0
Phase 2 - plateau phase R-HSA-5576893 5.206381e-01 0.283 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.228788e-01 0.282 0 0
Gastrulation R-HSA-9758941 5.231809e-01 0.281 0 0
Eukaryotic Translation Termination R-HSA-72764 5.276141e-01 0.278 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.284868e-01 0.277 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.284868e-01 0.277 0 0
GPCR downstream signalling R-HSA-388396 5.307029e-01 0.275 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.307407e-01 0.275 0 0
EGFR downregulation R-HSA-182971 5.347232e-01 0.272 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.359929e-01 0.271 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.359929e-01 0.271 0 0
MET promotes cell motility R-HSA-8875878 5.400291e-01 0.268 0 0
Regulated Necrosis R-HSA-5218859 5.401064e-01 0.268 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.415926e-01 0.266 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.415926e-01 0.266 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.447180e-01 0.264 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.453370e-01 0.263 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.453370e-01 0.263 0 0
Alanine metabolism R-HSA-8964540 5.453370e-01 0.263 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.453370e-01 0.263 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.453370e-01 0.263 0 0
Interferon gamma signaling R-HSA-877300 5.486976e-01 0.261 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.487108e-01 0.261 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.487108e-01 0.261 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.487108e-01 0.261 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 5.487108e-01 0.261 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.487108e-01 0.261 0 0
Formation of the posterior neural plate R-HSA-9832991 5.487108e-01 0.261 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.487108e-01 0.261 0 0
LGI-ADAM interactions R-HSA-5682910 5.487108e-01 0.261 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.487108e-01 0.261 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.489613e-01 0.260 0 0
Immune System R-HSA-168256 5.509755e-01 0.259 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.517501e-01 0.258 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.517501e-01 0.258 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.517501e-01 0.258 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.517501e-01 0.258 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.517501e-01 0.258 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.549461e-01 0.256 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.549461e-01 0.256 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.549461e-01 0.256 0 0
Leishmania infection R-HSA-9658195 5.559703e-01 0.255 0 0
Parasitic Infection Pathways R-HSA-9824443 5.559703e-01 0.255 0 0
Interleukin-1 family signaling R-HSA-446652 5.565223e-01 0.255 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.581311e-01 0.253 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.631315e-01 0.249 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.642436e-01 0.249 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.642436e-01 0.249 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 5.642436e-01 0.249 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 5.642436e-01 0.249 0 0
IRE1alpha activates chaperones R-HSA-381070 5.661969e-01 0.247 0 0
Signaling by FGFR R-HSA-190236 5.691245e-01 0.245 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.719310e-01 0.243 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.726516e-01 0.242 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.746301e-01 0.241 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 5.805899e-01 0.236 0 0
Interleukin-7 signaling R-HSA-1266695 5.805899e-01 0.236 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.809369e-01 0.236 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.816307e-01 0.235 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.816307e-01 0.235 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.816307e-01 0.235 0 0
Apoptotic factor-mediated response R-HSA-111471 5.816307e-01 0.235 0 0
FGFR1 ligand binding and activation R-HSA-190242 5.816307e-01 0.235 0 0
Tie2 Signaling R-HSA-210993 5.816307e-01 0.235 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.816307e-01 0.235 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.816307e-01 0.235 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.819713e-01 0.235 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.819713e-01 0.235 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.819713e-01 0.235 0 0
Aggrephagy R-HSA-9646399 5.819713e-01 0.235 0 0
Generation of second messenger molecules R-HSA-202433 5.819713e-01 0.235 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.859730e-01 0.232 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.859730e-01 0.232 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.859730e-01 0.232 0 0
ERKs are inactivated R-HSA-202670 5.859730e-01 0.232 0 0
NF-kB is activated and signals survival R-HSA-209560 5.859730e-01 0.232 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.859730e-01 0.232 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.859730e-01 0.232 0 0
Sodium/Calcium exchangers R-HSA-425561 5.859730e-01 0.232 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.859730e-01 0.232 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.859730e-01 0.232 0 0
Signaling by PTK6 R-HSA-8848021 5.867388e-01 0.232 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.867388e-01 0.232 0 0
Hedgehog 'on' state R-HSA-5632684 5.885506e-01 0.230 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.922660e-01 0.227 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.957554e-01 0.225 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.978508e-01 0.223 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 6.013190e-01 0.221 0 0
Activation of AMPA receptors R-HSA-399710 6.013190e-01 0.221 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.013190e-01 0.221 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.013190e-01 0.221 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.013190e-01 0.221 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.013190e-01 0.221 0 0
Activation of AKT2 R-HSA-165158 6.013190e-01 0.221 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.013190e-01 0.221 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.013190e-01 0.221 0 0
Suppression of autophagy R-HSA-9636569 6.013190e-01 0.221 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.013190e-01 0.221 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.013190e-01 0.221 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.013190e-01 0.221 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.013190e-01 0.221 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.013190e-01 0.221 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.020917e-01 0.220 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.021940e-01 0.220 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.030960e-01 0.220 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.035714e-01 0.219 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.041748e-01 0.219 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.053628e-01 0.218 0 0
Interleukin-1 signaling R-HSA-9020702 6.091586e-01 0.215 0 0
Selenocysteine synthesis R-HSA-2408557 6.091586e-01 0.215 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.102153e-01 0.215 0 0
Other interleukin signaling R-HSA-449836 6.102153e-01 0.215 0 0
Regulation of CDH1 Function R-HSA-9764561 6.196050e-01 0.208 0 0
Selective autophagy R-HSA-9663891 6.205074e-01 0.207 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.209041e-01 0.207 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.209041e-01 0.207 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.209041e-01 0.207 0 0
Interleukin-15 signaling R-HSA-8983432 6.209041e-01 0.207 0 0
OAS antiviral response R-HSA-8983711 6.209041e-01 0.207 0 0
Estrogen biosynthesis R-HSA-193144 6.209041e-01 0.207 0 0
Regulation of IFNG signaling R-HSA-877312 6.209041e-01 0.207 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.209041e-01 0.207 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.209041e-01 0.207 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.209041e-01 0.207 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.218744e-01 0.206 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.218744e-01 0.206 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.218744e-01 0.206 0 0
Translation of Structural Proteins R-HSA-9683701 6.218744e-01 0.206 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.245714e-01 0.204 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.285926e-01 0.202 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.292221e-01 0.201 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.292221e-01 0.201 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.292221e-01 0.201 0 0
Insulin processing R-HSA-264876 6.292221e-01 0.201 0 0
Interferon Signaling R-HSA-913531 6.318768e-01 0.199 0 0
Signaling by NOTCH4 R-HSA-9013694 6.345316e-01 0.198 0 0
Viral mRNA Translation R-HSA-192823 6.348678e-01 0.197 0 0
TCR signaling R-HSA-202403 6.353901e-01 0.197 0 0
Nephrin family interactions R-HSA-373753 6.374607e-01 0.196 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.409862e-01 0.193 0 0
PERK regulates gene expression R-HSA-381042 6.453332e-01 0.190 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.473979e-01 0.189 0 0
Adipogenesis R-HSA-9843745 6.486045e-01 0.188 0 0
PKB-mediated events R-HSA-109703 6.504110e-01 0.187 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.504110e-01 0.187 0 0
Cam-PDE 1 activation R-HSA-111957 6.504110e-01 0.187 0 0
PDE3B signalling R-HSA-165160 6.504110e-01 0.187 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.504110e-01 0.187 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.504110e-01 0.187 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.504110e-01 0.187 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.504110e-01 0.187 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.504110e-01 0.187 0 0
Signaling by MST1 R-HSA-8852405 6.504110e-01 0.187 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.504110e-01 0.187 0 0
NGF-independant TRKA activation R-HSA-187024 6.504110e-01 0.187 0 0
Ceramide signalling R-HSA-193681 6.504110e-01 0.187 0 0
Formation of the Editosome R-HSA-75094 6.504110e-01 0.187 0 0
Synthesis of PS R-HSA-1483101 6.504110e-01 0.187 0 0
Phosphorylation of Emi1 R-HSA-176417 6.504110e-01 0.187 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.504110e-01 0.187 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.504110e-01 0.187 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.504110e-01 0.187 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.504110e-01 0.187 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.504110e-01 0.187 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.504110e-01 0.187 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.504110e-01 0.187 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 6.521359e-01 0.186 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.521359e-01 0.186 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.521359e-01 0.186 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.521359e-01 0.186 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.521359e-01 0.186 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.521359e-01 0.186 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.521359e-01 0.186 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.535132e-01 0.185 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.535132e-01 0.185 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 6.535132e-01 0.185 0 0
FGFR4 ligand binding and activation R-HSA-190322 6.535132e-01 0.185 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.535132e-01 0.185 0 0
FGFR3 mutant receptor activation R-HSA-2033514 6.535132e-01 0.185 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.620765e-01 0.179 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.633430e-01 0.178 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.633430e-01 0.178 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.633430e-01 0.178 0 0
ERK/MAPK targets R-HSA-198753 6.633430e-01 0.178 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.633430e-01 0.178 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.633430e-01 0.178 0 0
Triglyceride catabolism R-HSA-163560 6.653585e-01 0.177 0 0
FLT3 signaling in disease R-HSA-9682385 6.653585e-01 0.177 0 0
GPVI-mediated activation cascade R-HSA-114604 6.653585e-01 0.177 0 0
Transcription of the HIV genome R-HSA-167172 6.656788e-01 0.177 0 0
Regulation of insulin secretion R-HSA-422356 6.726841e-01 0.172 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.740829e-01 0.171 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 6.740829e-01 0.171 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.740829e-01 0.171 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.740829e-01 0.171 0 0
Macroautophagy R-HSA-1632852 6.805182e-01 0.167 0 0
Platelet homeostasis R-HSA-418346 6.835899e-01 0.165 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.838425e-01 0.165 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.838425e-01 0.165 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.838425e-01 0.165 0 0
FGFR3c ligand binding and activation R-HSA-190372 6.838425e-01 0.165 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.838425e-01 0.165 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.838425e-01 0.165 0 0
MAP kinase activation R-HSA-450294 6.838945e-01 0.165 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.878547e-01 0.163 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.878547e-01 0.163 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.878547e-01 0.163 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.878547e-01 0.163 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.878547e-01 0.163 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.885373e-01 0.162 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.886624e-01 0.162 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.934604e-01 0.159 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.934604e-01 0.159 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 6.934604e-01 0.159 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.934604e-01 0.159 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.934604e-01 0.159 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.934604e-01 0.159 0 0
Abacavir transmembrane transport R-HSA-2161517 6.934604e-01 0.159 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.934604e-01 0.159 0 0
NADPH regeneration R-HSA-389542 6.934604e-01 0.159 0 0
Lipid particle organization R-HSA-8964572 6.934604e-01 0.159 0 0
VLDL assembly R-HSA-8866423 6.934604e-01 0.159 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.934604e-01 0.159 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.946294e-01 0.158 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 6.950506e-01 0.158 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.950506e-01 0.158 0 0
Synthesis of DNA R-HSA-69239 6.951649e-01 0.158 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.989238e-01 0.156 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.994677e-01 0.155 0 0
FGFR2 alternative splicing R-HSA-6803529 7.110020e-01 0.148 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.110020e-01 0.148 0 0
Integration of energy metabolism R-HSA-163685 7.112667e-01 0.148 0 0
Erythropoietin activates RAS R-HSA-9027284 7.119590e-01 0.148 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.119590e-01 0.148 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.119590e-01 0.148 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.119590e-01 0.148 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.119590e-01 0.148 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.119590e-01 0.148 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 7.119590e-01 0.148 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.119590e-01 0.148 0 0
Protein methylation R-HSA-8876725 7.119590e-01 0.148 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.139503e-01 0.146 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 7.150350e-01 0.146 0 0
Budding and maturation of HIV virion R-HSA-162588 7.150350e-01 0.146 0 0
G alpha (z) signalling events R-HSA-418597 7.195031e-01 0.143 0 0
Stabilization of p53 R-HSA-69541 7.208760e-01 0.142 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.274129e-01 0.138 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.312108e-01 0.136 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.312108e-01 0.136 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.312108e-01 0.136 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.312108e-01 0.136 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.312108e-01 0.136 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.312108e-01 0.136 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.312108e-01 0.136 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.312108e-01 0.136 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.312108e-01 0.136 0 0
VLDL clearance R-HSA-8964046 7.312108e-01 0.136 0 0
LDL remodeling R-HSA-8964041 7.312108e-01 0.136 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.312108e-01 0.136 0 0
Activation of TRKA receptors R-HSA-187015 7.312108e-01 0.136 0 0
Regulation of PTEN localization R-HSA-8948747 7.312108e-01 0.136 0 0
Glycoprotein hormones R-HSA-209822 7.312108e-01 0.136 0 0
CHL1 interactions R-HSA-447041 7.312108e-01 0.136 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.312108e-01 0.136 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.328028e-01 0.135 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.349996e-01 0.134 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.378427e-01 0.132 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.379475e-01 0.132 0 0
Differentiation of T cells R-HSA-9945266 7.379475e-01 0.132 0 0
Regulation of BACH1 activity R-HSA-9708530 7.379475e-01 0.132 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.379475e-01 0.132 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.379475e-01 0.132 0 0
Activation of SMO R-HSA-5635838 7.379475e-01 0.132 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.399428e-01 0.131 0 0
Leishmania phagocytosis R-HSA-9664417 7.490878e-01 0.125 0 0
Parasite infection R-HSA-9664407 7.490878e-01 0.125 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.490878e-01 0.125 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.511331e-01 0.124 0 0
Nuclear RNA decay R-HSA-9930044 7.520724e-01 0.124 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.532849e-01 0.123 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.532849e-01 0.123 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.540419e-01 0.123 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.540419e-01 0.123 0 0
Autophagy R-HSA-9612973 7.542996e-01 0.122 0 0
SARS-CoV Infections R-HSA-9679506 7.616838e-01 0.118 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.619057e-01 0.118 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.619057e-01 0.118 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.619057e-01 0.118 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.619057e-01 0.118 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.619057e-01 0.118 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.619057e-01 0.118 0 0
Synthesis of PG R-HSA-1483148 7.619057e-01 0.118 0 0
Hemostasis R-HSA-109582 7.624696e-01 0.118 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.643142e-01 0.117 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.643142e-01 0.117 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.643142e-01 0.117 0 0
MET receptor recycling R-HSA-8875656 7.643142e-01 0.117 0 0
Interleukin-9 signaling R-HSA-8985947 7.643142e-01 0.117 0 0
Regulation by c-FLIP R-HSA-3371378 7.643142e-01 0.117 0 0
Co-stimulation by ICOS R-HSA-9927354 7.643142e-01 0.117 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.643142e-01 0.117 0 0
Dimerization of procaspase-8 R-HSA-69416 7.643142e-01 0.117 0 0
Alpha-defensins R-HSA-1462054 7.643142e-01 0.117 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.643142e-01 0.117 0 0
Interleukin-23 signaling R-HSA-9020933 7.643142e-01 0.117 0 0
Kidney development R-HSA-9830369 7.666499e-01 0.115 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.691496e-01 0.114 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.691496e-01 0.114 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.694807e-01 0.114 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.694807e-01 0.114 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.716956e-01 0.113 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.724835e-01 0.112 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.724835e-01 0.112 0 0
G protein gated Potassium channels R-HSA-1296059 7.724835e-01 0.112 0 0
Tight junction interactions R-HSA-420029 7.724835e-01 0.112 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.724835e-01 0.112 0 0
Hyaluronan degradation R-HSA-2160916 7.724835e-01 0.112 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.724835e-01 0.112 0 0
Regulation of beta-cell development R-HSA-186712 7.749486e-01 0.111 0 0
Toll-like Receptor Cascades R-HSA-168898 7.795106e-01 0.108 0 0
Protein folding R-HSA-391251 7.816773e-01 0.107 0 0
Signaling by Insulin receptor R-HSA-74752 7.816773e-01 0.107 0 0
Translation of Structural Proteins R-HSA-9694635 7.829680e-01 0.106 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.839395e-01 0.106 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.839395e-01 0.106 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.839395e-01 0.106 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.839395e-01 0.106 0 0
Activation of GABAB receptors R-HSA-991365 7.841697e-01 0.106 0 0
GABA B receptor activation R-HSA-977444 7.841697e-01 0.106 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.852903e-01 0.105 0 0
Dual Incision in GG-NER R-HSA-5696400 7.852903e-01 0.105 0 0
Mitophagy R-HSA-5205647 7.852903e-01 0.105 0 0
Signaling by NOTCH2 R-HSA-1980145 7.852903e-01 0.105 0 0
rRNA processing R-HSA-72312 7.869734e-01 0.104 0 0
GABA receptor activation R-HSA-977443 7.874631e-01 0.104 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.890879e-01 0.103 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.904403e-01 0.102 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.904403e-01 0.102 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.904403e-01 0.102 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.933423e-01 0.101 0 0
CASP8 activity is inhibited R-HSA-5218900 7.933423e-01 0.101 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.933423e-01 0.101 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.933423e-01 0.101 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.933423e-01 0.101 0 0
Degradation of GABA R-HSA-916853 7.933423e-01 0.101 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.933423e-01 0.101 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.933423e-01 0.101 0 0
mRNA Editing R-HSA-75072 7.933423e-01 0.101 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.933423e-01 0.101 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.933423e-01 0.101 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.939439e-01 0.100 0 0
Orc1 removal from chromatin R-HSA-68949 7.980869e-01 0.098 0 0
Interleukin-17 signaling R-HSA-448424 8.016734e-01 0.096 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.041593e-01 0.095 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.041593e-01 0.095 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.041593e-01 0.095 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.041593e-01 0.095 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.041593e-01 0.095 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.072016e-01 0.093 0 0
Signaling by PDGF R-HSA-186797 8.109115e-01 0.091 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.109140e-01 0.091 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.124243e-01 0.090 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.124243e-01 0.090 0 0
PKR-mediated signaling R-HSA-9833482 8.145711e-01 0.089 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.148586e-01 0.089 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.148586e-01 0.089 0 0
2-LTR circle formation R-HSA-164843 8.187967e-01 0.087 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.187967e-01 0.087 0 0
Formation of apoptosome R-HSA-111458 8.187967e-01 0.087 0 0
Binding and entry of HIV virion R-HSA-173107 8.187967e-01 0.087 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.187967e-01 0.087 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.187967e-01 0.087 0 0
Maturation of spike protein R-HSA-9683686 8.187967e-01 0.087 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.187967e-01 0.087 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.187967e-01 0.087 0 0
Peptide hormone biosynthesis R-HSA-209952 8.187967e-01 0.087 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.187967e-01 0.087 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.187967e-01 0.087 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.218622e-01 0.085 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.226777e-01 0.085 0 0
Regulation of signaling by CBL R-HSA-912631 8.226777e-01 0.085 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.238849e-01 0.084 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.238849e-01 0.084 0 0
Signaling by GPCR R-HSA-372790 8.260992e-01 0.083 0 0
Degradation of DVL R-HSA-4641258 8.283418e-01 0.082 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.283418e-01 0.082 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.283418e-01 0.082 0 0
Cilium Assembly R-HSA-5617833 8.287480e-01 0.082 0 0
Ion transport by P-type ATPases R-HSA-936837 8.323103e-01 0.080 0 0
Platelet degranulation R-HSA-114608 8.326267e-01 0.080 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.331681e-01 0.079 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.373396e-01 0.077 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.396070e-01 0.076 0 0
Signaling by NODAL R-HSA-1181150 8.396070e-01 0.076 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.396070e-01 0.076 0 0
ChREBP activates metabolic gene expression R-HSA-163765 8.411171e-01 0.075 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.411171e-01 0.075 0 0
Chylomicron assembly R-HSA-8963888 8.411171e-01 0.075 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.411171e-01 0.075 0 0
Transport of RCbl within the body R-HSA-9758890 8.411171e-01 0.075 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.411171e-01 0.075 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.411171e-01 0.075 0 0
Suppression of apoptosis R-HSA-9635465 8.411171e-01 0.075 0 0
Prostanoid ligand receptors R-HSA-391908 8.411171e-01 0.075 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.495768e-01 0.071 0 0
Viral Infection Pathways R-HSA-9824446 8.505922e-01 0.070 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.508222e-01 0.070 0 0
DAP12 signaling R-HSA-2424491 8.508222e-01 0.070 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.508222e-01 0.070 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.508222e-01 0.070 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.528613e-01 0.069 0 0
G-protein activation R-HSA-202040 8.550575e-01 0.068 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.550575e-01 0.068 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.550575e-01 0.068 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.550575e-01 0.068 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.550575e-01 0.068 0 0
Intraflagellar transport R-HSA-5620924 8.574692e-01 0.067 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.606892e-01 0.065 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.606892e-01 0.065 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.606892e-01 0.065 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.606892e-01 0.065 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.606892e-01 0.065 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.606892e-01 0.065 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.606892e-01 0.065 0 0
Integration of provirus R-HSA-162592 8.606892e-01 0.065 0 0
Cargo concentration in the ER R-HSA-5694530 8.633197e-01 0.064 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.633197e-01 0.064 0 0
Attenuation phase R-HSA-3371568 8.639638e-01 0.064 0 0
PTEN Regulation R-HSA-6807070 8.684561e-01 0.061 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.691366e-01 0.061 0 0
G alpha (q) signalling events R-HSA-416476 8.712508e-01 0.060 0 0
Triglyceride metabolism R-HSA-8979227 8.721322e-01 0.059 0 0
Circadian clock R-HSA-9909396 8.726397e-01 0.059 0 0
Maturation of spike protein R-HSA-9694548 8.743402e-01 0.058 0 0
Integrin cell surface interactions R-HSA-216083 8.755464e-01 0.058 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.778513e-01 0.057 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.778513e-01 0.057 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.778513e-01 0.057 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.778513e-01 0.057 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.778513e-01 0.057 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.778513e-01 0.057 0 0
MET activates RAS signaling R-HSA-8851805 8.778513e-01 0.057 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.778513e-01 0.057 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.778513e-01 0.057 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.778513e-01 0.057 0 0
Signaling by KIT in disease R-HSA-9669938 8.819478e-01 0.055 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.819478e-01 0.055 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.819478e-01 0.055 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.819478e-01 0.055 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.819478e-01 0.055 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.819478e-01 0.055 0 0
LDL clearance R-HSA-8964038 8.819478e-01 0.055 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.819478e-01 0.055 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.829517e-01 0.054 0 0
Cellular response to starvation R-HSA-9711097 8.832099e-01 0.054 0 0
SLC transporter disorders R-HSA-5619102 8.849286e-01 0.053 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.851650e-01 0.053 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.855767e-01 0.053 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.873767e-01 0.052 0 0
Signaling by MET R-HSA-6806834 8.899881e-01 0.051 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.918915e-01 0.050 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.929001e-01 0.049 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 8.929001e-01 0.049 0 0
Acetylcholine binding and downstream events R-HSA-181431 8.929001e-01 0.049 0 0
Chylomicron remodeling R-HSA-8963901 8.929001e-01 0.049 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.929001e-01 0.049 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.929001e-01 0.049 0 0
Processing of SMDT1 R-HSA-8949664 8.929001e-01 0.049 0 0
Interleukin-6 signaling R-HSA-1059683 8.929001e-01 0.049 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.929001e-01 0.049 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.929001e-01 0.049 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.930528e-01 0.049 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.937592e-01 0.049 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.937592e-01 0.049 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.966679e-01 0.047 0 0
Nucleotide Excision Repair R-HSA-5696398 8.991498e-01 0.046 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.041556e-01 0.044 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.041556e-01 0.044 0 0
Complex III assembly R-HSA-9865881 9.041556e-01 0.044 0 0
Signal amplification R-HSA-392518 9.045377e-01 0.044 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.045377e-01 0.044 0 0
Hyaluronan metabolism R-HSA-2142845 9.045377e-01 0.044 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.060956e-01 0.043 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 9.060956e-01 0.043 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.060956e-01 0.043 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 9.060956e-01 0.043 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.060956e-01 0.043 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.060956e-01 0.043 0 0
P2Y receptors R-HSA-417957 9.060956e-01 0.043 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.060956e-01 0.043 0 0
Neutrophil degranulation R-HSA-6798695 9.089020e-01 0.041 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.090072e-01 0.041 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.092734e-01 0.041 0 0
Ribosome-associated quality control R-HSA-9948299 9.093399e-01 0.041 0 0
Regulation of Apoptosis R-HSA-169911 9.129104e-01 0.040 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 9.137342e-01 0.039 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 9.137342e-01 0.039 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.137342e-01 0.039 0 0
Interferon alpha/beta signaling R-HSA-909733 9.141531e-01 0.039 0 0
Cellular response to hypoxia R-HSA-1234174 9.161114e-01 0.038 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.165330e-01 0.038 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.176660e-01 0.037 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.176660e-01 0.037 0 0
Translesion synthesis by REV1 R-HSA-110312 9.176660e-01 0.037 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 9.176660e-01 0.037 0 0
Biotin transport and metabolism R-HSA-196780 9.176660e-01 0.037 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.176660e-01 0.037 0 0
Other semaphorin interactions R-HSA-416700 9.176660e-01 0.037 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.176660e-01 0.037 0 0
DNA Damage Reversal R-HSA-73942 9.176660e-01 0.037 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.177234e-01 0.037 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.177844e-01 0.037 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.206095e-01 0.036 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.206095e-01 0.036 0 0
RNA Polymerase III Transcription R-HSA-74158 9.206095e-01 0.036 0 0
Glycosphingolipid transport R-HSA-9845576 9.206095e-01 0.036 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.217733e-01 0.035 0 0
MET activates PTK2 signaling R-HSA-8874081 9.224082e-01 0.035 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.224082e-01 0.035 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.224082e-01 0.035 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.224082e-01 0.035 0 0
Sphingolipid catabolism R-HSA-9845614 9.224082e-01 0.035 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.232686e-01 0.035 0 0
Vesicle-mediated transport R-HSA-5653656 9.238387e-01 0.034 0 0
Collagen formation R-HSA-1474290 9.274413e-01 0.033 0 0
Translesion synthesis by POLI R-HSA-5656121 9.278113e-01 0.033 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.278113e-01 0.033 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.278113e-01 0.033 0 0
Fructose catabolism R-HSA-70350 9.278113e-01 0.033 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.278113e-01 0.033 0 0
Atorvastatin ADME R-HSA-9754706 9.278113e-01 0.033 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.295115e-01 0.032 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.295115e-01 0.032 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.326786e-01 0.030 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.341702e-01 0.030 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.361522e-01 0.029 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.367071e-01 0.028 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.367071e-01 0.028 0 0
Translesion synthesis by POLK R-HSA-5655862 9.367071e-01 0.028 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.367071e-01 0.028 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.367071e-01 0.028 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.367071e-01 0.028 0 0
Coenzyme A biosynthesis R-HSA-196783 9.367071e-01 0.028 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.367071e-01 0.028 0 0
Pyrimidine salvage R-HSA-73614 9.373469e-01 0.028 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.377985e-01 0.028 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.382751e-01 0.028 0 0
Gap junction trafficking and regulation R-HSA-157858 9.406385e-01 0.027 0 0
ER-Phagosome pathway R-HSA-1236974 9.427805e-01 0.026 0 0
mRNA Capping R-HSA-72086 9.437506e-01 0.025 0 0
Glucagon-type ligand receptors R-HSA-420092 9.437506e-01 0.025 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.445071e-01 0.025 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.445071e-01 0.025 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.445071e-01 0.025 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.445071e-01 0.025 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.445071e-01 0.025 0 0
Choline catabolism R-HSA-6798163 9.445071e-01 0.025 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.445071e-01 0.025 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.455644e-01 0.024 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.455644e-01 0.024 0 0
Glycogen metabolism R-HSA-8982491 9.455644e-01 0.024 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.462804e-01 0.024 0 0
Downstream TCR signaling R-HSA-202424 9.465707e-01 0.024 0 0
Collagen degradation R-HSA-1442490 9.474652e-01 0.023 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.475081e-01 0.023 0 0
Neurotransmitter clearance R-HSA-112311 9.495280e-01 0.022 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.501413e-01 0.022 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.501413e-01 0.022 0 0
The phototransduction cascade R-HSA-2514856 9.501413e-01 0.022 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.505472e-01 0.022 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.505472e-01 0.022 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.513462e-01 0.022 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 9.513462e-01 0.022 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.513462e-01 0.022 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.515789e-01 0.022 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.515789e-01 0.022 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.519306e-01 0.021 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.533818e-01 0.021 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.547361e-01 0.020 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.547361e-01 0.020 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.547361e-01 0.020 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.547361e-01 0.020 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.547361e-01 0.020 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.551017e-01 0.020 0 0
HIV Transcription Initiation R-HSA-167161 9.551017e-01 0.020 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.551017e-01 0.020 0 0
Intra-Golgi traffic R-HSA-6811438 9.551017e-01 0.020 0 0
Peptide hormone metabolism R-HSA-2980736 9.560316e-01 0.020 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.566399e-01 0.019 0 0
Pyrimidine biosynthesis R-HSA-500753 9.573428e-01 0.019 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.573428e-01 0.019 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.573428e-01 0.019 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.573428e-01 0.019 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.573428e-01 0.019 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.573428e-01 0.019 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.582278e-01 0.019 0 0
Nucleotide biosynthesis R-HSA-8956320 9.582278e-01 0.019 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.582278e-01 0.019 0 0
Phospholipid metabolism R-HSA-1483257 9.610793e-01 0.017 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 9.626006e-01 0.017 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.626006e-01 0.017 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.626006e-01 0.017 0 0
Keratan sulfate degradation R-HSA-2022857 9.626006e-01 0.017 0 0
Pregnenolone biosynthesis R-HSA-196108 9.626006e-01 0.017 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.626006e-01 0.017 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.630568e-01 0.016 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.636506e-01 0.016 0 0
Selenoamino acid metabolism R-HSA-2408522 9.649380e-01 0.016 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.650859e-01 0.015 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.653669e-01 0.015 0 0
PPARA activates gene expression R-HSA-1989781 9.656330e-01 0.015 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.663304e-01 0.015 0 0
Gap junction trafficking R-HSA-190828 9.665175e-01 0.015 0 0
DAP12 interactions R-HSA-2172127 9.665175e-01 0.015 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.672106e-01 0.014 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.672106e-01 0.014 0 0
Basigin interactions R-HSA-210991 9.672106e-01 0.014 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.674493e-01 0.014 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.681077e-01 0.014 0 0
PCP/CE pathway R-HSA-4086400 9.689123e-01 0.014 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.693872e-01 0.014 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.696706e-01 0.013 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.696706e-01 0.013 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.706745e-01 0.013 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.708641e-01 0.013 0 0
eNOS activation R-HSA-203615 9.708641e-01 0.013 0 0
Gap junction assembly R-HSA-190861 9.708641e-01 0.013 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.708641e-01 0.013 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.708641e-01 0.013 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.708641e-01 0.013 0 0
Synthesis of PA R-HSA-1483166 9.708840e-01 0.013 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.712527e-01 0.013 0 0
Serine metabolism R-HSA-977347 9.712527e-01 0.013 0 0
Glutathione synthesis and recycling R-HSA-174403 9.712527e-01 0.013 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.716557e-01 0.012 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.716710e-01 0.012 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.725412e-01 0.012 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.734328e-01 0.012 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.734328e-01 0.012 0 0
Cellular response to chemical stress R-HSA-9711123 9.735066e-01 0.012 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.739319e-01 0.011 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.747966e-01 0.011 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.747966e-01 0.011 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.747966e-01 0.011 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.747966e-01 0.011 0 0
Fructose metabolism R-HSA-5652084 9.747966e-01 0.011 0 0
COPII-mediated vesicle transport R-HSA-204005 9.752968e-01 0.011 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.766863e-01 0.010 0 0
Mitochondrial biogenesis R-HSA-1592230 9.769372e-01 0.010 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.779038e-01 0.010 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.779038e-01 0.010 0 0
Formation of the ureteric bud R-HSA-9830674 9.779038e-01 0.010 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.779038e-01 0.010 0 0
Carnitine shuttle R-HSA-200425 9.779038e-01 0.010 0 0
Interleukin-20 family signaling R-HSA-8854691 9.779038e-01 0.010 0 0
RAB geranylgeranylation R-HSA-8873719 9.779151e-01 0.010 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.779151e-01 0.010 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.791581e-01 0.009 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.791581e-01 0.009 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.791581e-01 0.009 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.791581e-01 0.009 0 0
Collagen chain trimerization R-HSA-8948216 9.791581e-01 0.009 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.796845e-01 0.009 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.798793e-01 0.009 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.806282e-01 0.008 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.806282e-01 0.008 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.806282e-01 0.008 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.806282e-01 0.008 0 0
Interleukin-6 family signaling R-HSA-6783589 9.806282e-01 0.008 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.813749e-01 0.008 0 0
Elastic fibre formation R-HSA-1566948 9.813749e-01 0.008 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.816777e-01 0.008 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.820149e-01 0.008 0 0
Neddylation R-HSA-8951664 9.822692e-01 0.008 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.830167e-01 0.007 0 0
Laminin interactions R-HSA-3000157 9.830167e-01 0.007 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.833620e-01 0.007 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.833620e-01 0.007 0 0
RAS processing R-HSA-9648002 9.833620e-01 0.007 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.833620e-01 0.007 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.840510e-01 0.007 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.850327e-01 0.007 0 0
Urea cycle R-HSA-70635 9.851109e-01 0.007 0 0
Abacavir ADME R-HSA-2161522 9.851109e-01 0.007 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.851109e-01 0.007 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.851425e-01 0.007 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.852008e-01 0.006 0 0
Potential therapeutics for SARS R-HSA-9679191 9.857465e-01 0.006 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.864560e-01 0.006 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.864937e-01 0.006 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.867370e-01 0.006 0 0
tRNA processing R-HSA-72306 9.869147e-01 0.006 0 0
Cristae formation R-HSA-8949613 9.869469e-01 0.006 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.869469e-01 0.006 0 0
Triglyceride biosynthesis R-HSA-75109 9.869469e-01 0.006 0 0
Synthesis of PE R-HSA-1483213 9.869469e-01 0.006 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.869469e-01 0.006 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.869469e-01 0.006 0 0
Signaling by BMP R-HSA-201451 9.869469e-01 0.006 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.869469e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.874597e-01 0.005 0 0
Cholesterol biosynthesis R-HSA-191273 9.878018e-01 0.005 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.878172e-01 0.005 0 0
Prednisone ADME R-HSA-9757110 9.885567e-01 0.005 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.885567e-01 0.005 0 0
Nicotinate metabolism R-HSA-196807 9.886065e-01 0.005 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.886870e-01 0.005 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.894413e-01 0.005 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.894413e-01 0.005 0 0
Thyroxine biosynthesis R-HSA-209968 9.899680e-01 0.004 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.899680e-01 0.004 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.899680e-01 0.004 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.900998e-01 0.004 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.905835e-01 0.004 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.905835e-01 0.004 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.905835e-01 0.004 0 0
Mucopolysaccharidoses R-HSA-2206281 9.912053e-01 0.004 0 0
Surfactant metabolism R-HSA-5683826 9.916047e-01 0.004 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.919334e-01 0.004 0 0
Dual incision in TC-NER R-HSA-6782135 9.919672e-01 0.004 0 0
Metabolism of cofactors R-HSA-8978934 9.922686e-01 0.003 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.922901e-01 0.003 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.925172e-01 0.003 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.925172e-01 0.003 0 0
Somitogenesis R-HSA-9824272 9.925172e-01 0.003 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.932411e-01 0.003 0 0
HS-GAG degradation R-HSA-2024096 9.932411e-01 0.003 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.933325e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.934918e-01 0.003 0 0
G alpha (i) signalling events R-HSA-418594 9.940309e-01 0.003 0 0
Synthesis of PC R-HSA-1483191 9.940605e-01 0.003 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.941418e-01 0.003 0 0
Nucleotide salvage R-HSA-8956321 9.941450e-01 0.003 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.947105e-01 0.002 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.948058e-01 0.002 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.948058e-01 0.002 0 0
Heme degradation R-HSA-189483 9.948058e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.952905e-01 0.002 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.954466e-01 0.002 0 0
Azathioprine ADME R-HSA-9748787 9.958079e-01 0.002 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.958636e-01 0.002 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.960084e-01 0.002 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.960084e-01 0.002 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.960084e-01 0.002 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.960718e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.961345e-01 0.002 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.962694e-01 0.002 0 0
HSF1 activation R-HSA-3371511 9.965009e-01 0.002 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.966809e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.969171e-01 0.001 0 0
Degradation of AXIN R-HSA-4641257 9.969327e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.969327e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.969327e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.971354e-01 0.001 0 0
Purine salvage R-HSA-74217 9.973112e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.973112e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.973315e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.973315e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.974105e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.976430e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.976430e-01 0.001 0 0
RSV-host interactions R-HSA-9833110 9.976902e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.977345e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.979197e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.979339e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.980017e-01 0.001 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.981889e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.982082e-01 0.001 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.982561e-01 0.001 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.984125e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.984522e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.984928e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.985441e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.985606e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.986168e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.987068e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.987103e-01 0.001 0 0
Defensins R-HSA-1461973 9.987802e-01 0.001 0 0
Proteasome assembly R-HSA-9907900 9.989308e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.989308e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.989773e-01 0.000 0 0
Mitochondrial protein import R-HSA-1268020 9.989803e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.990628e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.991148e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.991785e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.991965e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.992799e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.992799e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.993564e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.993812e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.994387e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.994468e-01 0.000 0 0
Disease R-HSA-1643685 9.995652e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.995750e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.996528e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.996528e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.996922e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.997120e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.997492e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.997802e-01 0.000 0 0
Digestion R-HSA-8935690 9.997802e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.997857e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.998073e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998146e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.998510e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.998520e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.998520e-01 0.000 0 0
Protein localization R-HSA-9609507 9.998653e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.998703e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.998703e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.998863e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998965e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999127e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999134e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999235e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999282e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999296e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999329e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999437e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999485e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999549e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999560e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999605e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999610e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999630e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.999653e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999693e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999695e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999696e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999767e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999813e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999815e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999836e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999894e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999921e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999950e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999963e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999967e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999971e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999974e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999982e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999984e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999988e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999992e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999994e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999996e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999996e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999997e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999997e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Translation R-HSA-72766 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 4.540812e-14 13.343 0 0
Cell Cycle Checkpoints R-HSA-69620 8.761070e-11 10.057 0 0
Chromatin organization R-HSA-4839726 1.384606e-10 9.859 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.772646e-10 9.169 0 0
Mitotic Prometaphase R-HSA-68877 3.299937e-09 8.481 0 0
Cellular responses to stimuli R-HSA-8953897 5.759846e-09 8.240 1 0
Chromatin modifying enzymes R-HSA-3247509 7.745778e-09 8.111 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.407053e-08 7.619 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.287556e-08 7.368 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.809325e-08 7.318 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.219318e-08 7.206 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.784971e-08 7.168 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.208609e-07 6.918 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.128571e-07 6.672 0 0
Cellular responses to stress R-HSA-2262752 2.084007e-07 6.681 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.921340e-07 6.160 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.289474e-07 6.137 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.205345e-06 5.919 0 0
Mitotic Anaphase R-HSA-68882 1.197744e-06 5.922 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.349639e-06 5.870 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.520583e-06 5.818 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.875915e-06 5.727 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.875915e-06 5.727 0 0
Mitotic Prophase R-HSA-68875 1.918492e-06 5.717 0 0
Separation of Sister Chromatids R-HSA-2467813 1.794572e-06 5.746 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.252235e-06 5.647 0 0
Cellular Senescence R-HSA-2559583 3.191451e-06 5.496 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.513934e-06 5.454 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.076055e-06 5.390 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.270644e-06 5.278 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.270644e-06 5.278 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.077663e-06 5.294 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.730312e-06 5.242 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.113771e-06 5.214 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.580208e-06 5.182 0 0
Nucleosome assembly R-HSA-774815 6.580208e-06 5.182 0 0
HDACs deacetylate histones R-HSA-3214815 6.592714e-06 5.181 0 0
Cell-Cell communication R-HSA-1500931 8.444145e-06 5.073 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 9.475548e-06 5.023 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.906236e-06 5.004 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.396627e-05 4.855 0 0
G2/M Transition R-HSA-69275 1.427580e-05 4.845 0 0
G2/M Checkpoints R-HSA-69481 1.579808e-05 4.801 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.738648e-05 4.760 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.791357e-05 4.747 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.101576e-05 4.677 0 0
Homology Directed Repair R-HSA-5693538 2.187892e-05 4.660 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.584402e-05 4.588 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.599798e-05 4.585 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.883313e-05 4.540 0 0
DNA Double Strand Break Response R-HSA-5693606 2.764231e-05 4.558 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.828055e-05 4.549 0 0
Meiotic recombination R-HSA-912446 2.807685e-05 4.552 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.706622e-05 4.568 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.931395e-05 4.533 0 0
DNA methylation R-HSA-5334118 3.268602e-05 4.486 0 0
Meiosis R-HSA-1500620 3.357468e-05 4.474 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.455087e-05 4.462 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.618496e-05 4.441 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.700605e-05 4.432 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.700605e-05 4.432 0 0
Meiotic synapsis R-HSA-1221632 4.351210e-05 4.361 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.728018e-05 4.325 0 0
Defective pyroptosis R-HSA-9710421 4.785462e-05 4.320 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.461852e-05 4.263 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.591337e-05 4.252 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.485260e-05 4.188 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.414748e-05 4.193 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.414748e-05 4.193 0 0
Diseases of programmed cell death R-HSA-9645723 6.485260e-05 4.188 0 0
AURKA Activation by TPX2 R-HSA-8854518 6.577299e-05 4.182 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.876396e-05 4.104 0 0
HATs acetylate histones R-HSA-3214847 7.540203e-05 4.123 0 0
Signal Transduction R-HSA-162582 8.178039e-05 4.087 1 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.451481e-05 4.025 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.165728e-05 4.038 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.165728e-05 4.038 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.985758e-05 4.001 0 0
mRNA Splicing R-HSA-72172 1.054584e-04 3.977 0 0
Metabolism of RNA R-HSA-8953854 1.089135e-04 3.963 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.193804e-04 3.923 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.241465e-04 3.906 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.289986e-04 3.889 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.343250e-04 3.872 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.402891e-04 3.853 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.452430e-04 3.838 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.628735e-04 3.788 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.628735e-04 3.788 0 0
Translation initiation complex formation R-HSA-72649 1.607046e-04 3.794 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.548488e-04 3.810 0 0
ESR-mediated signaling R-HSA-8939211 1.671620e-04 3.777 0 0
Kinesins R-HSA-983189 1.732580e-04 3.761 0 0
RNA Polymerase I Transcription R-HSA-73864 1.908232e-04 3.719 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.056176e-04 3.687 0 0
Polo-like kinase mediated events R-HSA-156711 2.195348e-04 3.658 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.213150e-04 3.655 0 0
DNA Replication R-HSA-69306 2.448359e-04 3.611 0 0
Cell junction organization R-HSA-446728 2.537293e-04 3.596 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.556538e-04 3.592 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.718868e-04 3.566 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.561317e-04 3.592 0 0
Packaging Of Telomere Ends R-HSA-171306 2.748395e-04 3.561 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.782082e-04 3.556 0 0
Centrosome maturation R-HSA-380287 3.038433e-04 3.517 0 0
Reproduction R-HSA-1474165 2.943699e-04 3.531 0 0
Apoptotic execution phase R-HSA-75153 2.905111e-04 3.537 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.202749e-04 3.494 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.513424e-04 3.454 1 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.543983e-04 3.451 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.545391e-04 3.450 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.538889e-04 3.343 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.558358e-04 3.341 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.200974e-04 3.284 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 5.224763e-04 3.282 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.496987e-04 3.260 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.496987e-04 3.260 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.680522e-04 3.246 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.523607e-04 3.258 0 0
Signal amplification R-HSA-392518 5.615538e-04 3.251 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.942884e-04 3.226 0 0
Signaling by ROBO receptors R-HSA-376176 5.933831e-04 3.227 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.615538e-04 3.251 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.074028e-04 3.217 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.093184e-04 3.215 1 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.113986e-04 3.214 0 0
Signaling by WNT R-HSA-195721 6.434626e-04 3.191 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.453875e-04 3.190 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 6.576617e-04 3.182 0 0
Signaling by Hippo R-HSA-2028269 6.843665e-04 3.165 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.985200e-04 3.156 0 0
DNA Repair R-HSA-73894 7.182572e-04 3.144 0 0
Adherens junctions interactions R-HSA-418990 6.811803e-04 3.167 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.244497e-04 3.140 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.295687e-04 3.137 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.330905e-04 3.135 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.833160e-04 3.106 0 0
Chromosome Maintenance R-HSA-73886 7.952441e-04 3.099 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.076884e-04 3.093 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.740443e-04 3.058 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.801031e-04 3.055 0 0
Peptide chain elongation R-HSA-156902 9.202500e-04 3.036 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.309986e-04 3.031 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 9.987010e-04 3.001 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.098319e-03 2.959 0 0
Axon guidance R-HSA-422475 1.026120e-03 2.989 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.185457e-03 2.926 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.225175e-03 2.912 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.273896e-03 2.895 0 0
Nervous system development R-HSA-9675108 1.304941e-03 2.884 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.422077e-03 2.847 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.494438e-03 2.826 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.494438e-03 2.826 1 1
Co-inhibition by PD-1 R-HSA-389948 1.510671e-03 2.821 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.516264e-03 2.819 0 0
Cell-cell junction organization R-HSA-421270 1.560334e-03 2.807 0 0
Opioid Signalling R-HSA-111885 1.665365e-03 2.778 0 0
Protein folding R-HSA-391251 1.708625e-03 2.767 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.948557e-03 2.710 0 0
Unwinding of DNA R-HSA-176974 1.964711e-03 2.707 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.069488e-03 2.684 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.302061e-03 2.638 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.308048e-03 2.637 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.434183e-03 2.614 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.604729e-03 2.584 0 0
G alpha (12/13) signalling events R-HSA-416482 2.623238e-03 2.581 0 0
Recycling pathway of L1 R-HSA-437239 2.706873e-03 2.568 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.954549e-03 2.530 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.910623e-03 2.536 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.149474e-03 2.502 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.029531e-03 2.519 0 0
Cleavage of the damaged purine R-HSA-110331 3.074432e-03 2.512 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.159833e-03 2.500 0 0
Depyrimidination R-HSA-73928 3.159833e-03 2.500 0 0
G-protein beta:gamma signalling R-HSA-397795 3.502827e-03 2.456 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.555177e-03 2.449 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 3.573504e-03 2.447 0 0
Presynaptic function of Kainate receptors R-HSA-500657 3.573504e-03 2.447 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.610504e-03 2.442 0 0
Depurination R-HSA-73927 3.665656e-03 2.436 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.794208e-03 2.421 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.794208e-03 2.421 0 0
Apoptosis R-HSA-109581 3.873033e-03 2.412 0 0
Protein ubiquitination R-HSA-8852135 4.031386e-03 2.395 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.225773e-03 2.374 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.225773e-03 2.374 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.320129e-03 2.365 0 0
G beta:gamma signalling through BTK R-HSA-8964315 4.604463e-03 2.337 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.040769e-03 2.298 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.040769e-03 2.298 0 0
Aggrephagy R-HSA-9646399 5.121961e-03 2.291 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.649244e-03 2.333 0 0
Base Excision Repair R-HSA-73884 5.441726e-03 2.264 0 0
Signaling by NOTCH R-HSA-157118 5.584789e-03 2.253 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.851425e-03 2.233 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.851425e-03 2.233 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.042056e-03 2.219 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.491963e-03 2.188 0 0
Gene expression (Transcription) R-HSA-74160 6.740470e-03 2.171 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.778388e-03 2.169 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.792284e-03 2.168 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 6.792284e-03 2.168 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.911905e-03 2.160 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.944734e-03 2.158 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.946157e-03 2.158 0 0
S Phase R-HSA-69242 7.199352e-03 2.143 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.774095e-03 2.109 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.764471e-03 2.110 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.764471e-03 2.110 0 0
DNA strand elongation R-HSA-69190 8.272103e-03 2.082 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.764471e-03 2.110 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.266004e-03 2.139 0 0
L1CAM interactions R-HSA-373760 7.332297e-03 2.135 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 8.379004e-03 2.077 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 9.638633e-03 2.016 0 0
ALK mutants bind TKIs R-HSA-9700645 9.638633e-03 2.016 0 0
Interleukin-12 signaling R-HSA-9020591 9.653967e-03 2.015 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.772082e-03 2.010 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 9.772082e-03 2.010 0 0
Signaling by ALK in cancer R-HSA-9700206 9.772082e-03 2.010 0 0
Selenocysteine synthesis R-HSA-2408557 9.864850e-03 2.006 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.910303e-03 2.004 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.025145e-02 1.989 0 0
Eukaryotic Translation Termination R-HSA-72764 1.088215e-02 1.963 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.128950e-02 1.947 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.149867e-02 1.939 0 0
Viral mRNA Translation R-HSA-192823 1.180122e-02 1.928 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.192874e-02 1.923 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.229316e-02 1.910 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.231562e-02 1.910 0 0
Telomere Maintenance R-HSA-157579 1.305393e-02 1.884 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.321292e-02 1.879 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.322054e-02 1.879 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.329066e-02 1.876 0 0
rRNA processing R-HSA-72312 1.379980e-02 1.860 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.593771e-02 1.798 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.492849e-02 1.826 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.649132e-02 1.783 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.649132e-02 1.783 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.649132e-02 1.783 0 0
Activation of BH3-only proteins R-HSA-114452 1.599189e-02 1.796 0 0
The NLRP3 inflammasome R-HSA-844456 1.515886e-02 1.819 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 1.515886e-02 1.819 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 1.593771e-02 1.798 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.646152e-02 1.784 0 0
Ribosome-associated quality control R-HSA-9948299 1.656732e-02 1.781 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.657920e-02 1.780 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.679679e-02 1.775 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.679993e-02 1.775 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.679993e-02 1.775 0 0
Programmed Cell Death R-HSA-5357801 1.760952e-02 1.754 0 0
Gene Silencing by RNA R-HSA-211000 1.798328e-02 1.745 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.847016e-02 1.734 0 0
Nephrin family interactions R-HSA-373753 1.847016e-02 1.734 0 0
HDMs demethylate histones R-HSA-3214842 1.894592e-02 1.722 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.942177e-02 1.712 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.942177e-02 1.712 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.942177e-02 1.712 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.942177e-02 1.712 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.942177e-02 1.712 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.946114e-02 1.711 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.095748e-02 1.679 0 0
Phosphorylation of the APC/C R-HSA-176412 2.095748e-02 1.679 0 0
NRAGE signals death through JNK R-HSA-193648 2.106982e-02 1.676 0 0
G0 and Early G1 R-HSA-1538133 2.171331e-02 1.663 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.202744e-02 1.657 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.225829e-02 1.653 0 0
G-protein activation R-HSA-202040 2.225829e-02 1.653 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 2.233893e-02 1.651 0 0
Myogenesis R-HSA-525793 2.233893e-02 1.651 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.659785e-02 1.575 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.263904e-02 1.645 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.282652e-02 1.642 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.282652e-02 1.642 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.282652e-02 1.642 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.655211e-02 1.576 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.318150e-02 1.635 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.506699e-02 1.601 0 0
Cilium Assembly R-HSA-5617833 2.697751e-02 1.569 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.279503e-02 1.642 0 0
Membrane Trafficking R-HSA-199991 2.345974e-02 1.630 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.263904e-02 1.645 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.506699e-02 1.601 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.506699e-02 1.601 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.341941e-02 1.630 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 2.659785e-02 1.575 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.613905e-02 1.583 0 0
Sensory processing of sound R-HSA-9659379 2.574084e-02 1.589 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.805421e-02 1.552 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 2.805421e-02 1.552 0 0
PKR-mediated signaling R-HSA-9833482 2.812991e-02 1.551 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.858288e-02 1.544 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.877232e-02 1.541 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.877232e-02 1.541 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.898117e-02 1.538 0 0
Post NMDA receptor activation events R-HSA-438064 2.995402e-02 1.524 0 0
Interleukin-12 family signaling R-HSA-447115 2.995402e-02 1.524 0 0
Deubiquitination R-HSA-5688426 3.003144e-02 1.522 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.010430e-02 1.521 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.036698e-02 1.518 0 0
Amyloid fiber formation R-HSA-977225 3.067986e-02 1.513 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.125420e-02 1.505 0 0
Specification of primordial germ cells R-HSA-9827857 3.125420e-02 1.505 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.144554e-02 1.502 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.144554e-02 1.502 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.144554e-02 1.502 0 0
Signaling by RAS mutants R-HSA-6802949 3.144554e-02 1.502 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.243879e-02 1.489 0 0
Selective autophagy R-HSA-9663891 3.250899e-02 1.488 0 0
Cellular response to heat stress R-HSA-3371556 3.370790e-02 1.472 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.434154e-02 1.464 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.434154e-02 1.464 0 0
FLT3 Signaling R-HSA-9607240 3.434154e-02 1.464 0 0
DARPP-32 events R-HSA-180024 3.504163e-02 1.455 0 0
Glucagon-type ligand receptors R-HSA-420092 3.504163e-02 1.455 0 0
Influenza Infection R-HSA-168255 3.514917e-02 1.454 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 3.913421e-02 1.407 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 3.913421e-02 1.407 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.913421e-02 1.407 0 0
Lipophagy R-HSA-9613354 3.993925e-02 1.399 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.609254e-02 1.443 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.609254e-02 1.443 0 0
Ephrin signaling R-HSA-3928664 3.745429e-02 1.426 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.745429e-02 1.426 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.438845e-02 1.353 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.438845e-02 1.353 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.215103e-02 1.375 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.855316e-02 1.414 0 0
GPER1 signaling R-HSA-9634597 3.908348e-02 1.408 0 0
Regulation of TP53 Activity R-HSA-5633007 4.322264e-02 1.364 0 0
MTOR signalling R-HSA-165159 4.310765e-02 1.365 0 0
Rap1 signalling R-HSA-392517 4.438845e-02 1.353 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.079305e-02 1.389 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.017987e-02 1.396 0 0
Cellular response to starvation R-HSA-9711097 3.863026e-02 1.413 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.745429e-02 1.426 0 0
Calmodulin induced events R-HSA-111933 4.215103e-02 1.375 0 0
CaM pathway R-HSA-111997 4.215103e-02 1.375 0 0
RNA Polymerase II Transcription R-HSA-73857 4.206329e-02 1.376 0 0
Signal regulatory protein family interactions R-HSA-391160 4.418942e-02 1.355 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.271271e-02 1.369 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.308450e-02 1.366 0 0
Interleukin-1 processing R-HSA-448706 3.993925e-02 1.399 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.017987e-02 1.396 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.855316e-02 1.414 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.308450e-02 1.366 0 0
Interleukin-37 signaling R-HSA-9008059 4.017987e-02 1.396 0 0
Signaling by VEGF R-HSA-194138 4.655168e-02 1.332 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.735068e-02 1.325 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.735068e-02 1.325 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.740891e-02 1.324 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.914478e-02 1.309 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.925774e-02 1.308 0 0
G protein gated Potassium channels R-HSA-1296059 4.925774e-02 1.308 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.925774e-02 1.308 0 0
Interleukin-7 signaling R-HSA-1266695 4.925774e-02 1.308 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.948403e-02 1.306 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.076808e-02 1.294 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.076808e-02 1.294 0 0
Regulation of CDH11 function R-HSA-9762292 5.076808e-02 1.294 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.076808e-02 1.294 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.156443e-02 1.288 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.190339e-02 1.285 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.207369e-02 1.283 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.207369e-02 1.283 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.207369e-02 1.283 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.207369e-02 1.283 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.207369e-02 1.283 0 0
Negative regulation of MET activity R-HSA-6807004 5.207369e-02 1.283 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 5.328341e-02 1.273 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.328868e-02 1.273 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.328868e-02 1.273 0 0
Protein methylation R-HSA-8876725 5.328868e-02 1.273 0 0
Ca2+ pathway R-HSA-4086398 5.341467e-02 1.272 0 0
Synthesis of DNA R-HSA-69239 5.373315e-02 1.270 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.415071e-02 1.266 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.415071e-02 1.266 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.415071e-02 1.266 0 0
HCMV Early Events R-HSA-9609690 5.552019e-02 1.256 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.760581e-02 1.240 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.782565e-02 1.238 0 0
DAG and IP3 signaling R-HSA-1489509 5.892074e-02 1.230 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.918513e-02 1.228 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.016058e-02 1.221 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.052064e-02 1.218 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.247750e-02 1.204 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 6.304218e-02 1.200 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.310780e-02 1.200 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.339550e-02 1.198 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 6.416395e-02 1.193 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.492943e-02 1.188 0 0
Signaling by NOTCH1 R-HSA-1980143 6.737399e-02 1.172 0 0
Regulation of TP53 Expression R-HSA-6804754 6.774183e-02 1.169 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.150540e-02 1.146 0 0
HIV elongation arrest and recovery R-HSA-167287 7.253798e-02 1.139 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.253798e-02 1.139 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.253798e-02 1.139 0 0
Inflammasomes R-HSA-622312 7.253798e-02 1.139 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 9.101164e-02 1.041 0 0
Disinhibition of SNARE formation R-HSA-114516 9.101164e-02 1.041 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.672694e-02 1.115 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 9.176796e-02 1.037 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 9.176796e-02 1.037 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 9.176796e-02 1.037 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 9.176796e-02 1.037 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 9.176796e-02 1.037 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.659732e-02 1.062 0 0
Notch-HLH transcription pathway R-HSA-350054 7.971079e-02 1.098 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.223591e-02 1.085 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.499063e-02 1.071 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.268893e-02 1.139 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.971079e-02 1.098 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.301138e-02 1.137 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 9.176796e-02 1.037 0 0
Activation of the pre-replicative complex R-HSA-68962 9.113081e-02 1.040 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.525966e-02 1.069 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.405658e-02 1.027 0 0
Integration of provirus R-HSA-162592 7.672694e-02 1.115 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.301138e-02 1.137 0 0
RET signaling R-HSA-8853659 9.005077e-02 1.046 0 0
MAP2K and MAPK activation R-HSA-5674135 8.009939e-02 1.096 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.450389e-02 1.128 0 0
Heme signaling R-HSA-9707616 7.301138e-02 1.137 0 0
PTEN Regulation R-HSA-6807070 7.380195e-02 1.132 0 0
Ion homeostasis R-HSA-5578775 8.223591e-02 1.085 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.577965e-02 1.120 0 0
Ca-dependent events R-HSA-111996 8.795082e-02 1.056 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.659732e-02 1.062 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.773348e-02 1.057 0 0
NGF-stimulated transcription R-HSA-9031628 7.809976e-02 1.107 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 7.672694e-02 1.115 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 9.412815e-02 1.026 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.499063e-02 1.071 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.380195e-02 1.132 0 0
MHC class II antigen presentation R-HSA-2132295 9.689535e-02 1.014 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 9.893553e-02 1.005 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 9.893553e-02 1.005 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 9.921685e-02 1.003 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.964959e-02 1.002 0 0
Mismatch Repair R-HSA-5358508 9.964959e-02 1.002 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.964959e-02 1.002 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.003036e-01 0.999 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.003036e-01 0.999 0 0
Defective SFTPA2 causes IPF R-HSA-5687868 1.003036e-01 0.999 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.003036e-01 0.999 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.003036e-01 0.999 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.003036e-01 0.999 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.003036e-01 0.999 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.003036e-01 0.999 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.003036e-01 0.999 0 0
Deadenylation of mRNA R-HSA-429947 1.019203e-01 0.992 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.019203e-01 0.992 0 0
Neurodegenerative Diseases R-HSA-8863678 1.019203e-01 0.992 0 0
RMTs methylate histone arginines R-HSA-3214858 1.049710e-01 0.979 0 0
Signaling by Hedgehog R-HSA-5358351 1.054438e-01 0.977 0 0
G-protein mediated events R-HSA-112040 1.062293e-01 0.974 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.080942e-01 0.966 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.080942e-01 0.966 0 0
Viral Infection Pathways R-HSA-9824446 1.087210e-01 0.964 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.090474e-01 0.962 0 0
mRNA 3'-end processing R-HSA-72187 1.090474e-01 0.962 0 0
Orc1 removal from chromatin R-HSA-68949 1.090474e-01 0.962 0 0
Neurexins and neuroligins R-HSA-6794361 1.090474e-01 0.962 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.091300e-01 0.962 0 0
Signaling by ERBB2 R-HSA-1227986 1.118860e-01 0.951 0 0
Inwardly rectifying K+ channels R-HSA-1296065 1.121429e-01 0.950 0 0
Type I hemidesmosome assembly R-HSA-446107 1.124533e-01 0.949 0 0
Formation of annular gap junctions R-HSA-196025 1.124533e-01 0.949 0 0
G1/S Transition R-HSA-69206 1.128170e-01 0.948 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.141201e-01 0.943 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.156767e-01 0.937 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.158223e-01 0.936 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.171766e-01 0.931 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.177382e-01 0.929 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.177382e-01 0.929 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.190549e-01 0.924 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.199847e-01 0.921 0 0
PLC beta mediated events R-HSA-112043 1.201461e-01 0.920 0 0
Aquaporin-mediated transport R-HSA-445717 1.201461e-01 0.920 0 0
Regulation of insulin secretion R-HSA-422356 1.222649e-01 0.913 0 0
IRE1alpha activates chaperones R-HSA-381070 1.226923e-01 0.911 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.227965e-01 0.911 0 0
Integrin signaling R-HSA-354192 1.235276e-01 0.908 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.235276e-01 0.908 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.235276e-01 0.908 0 0
Diseases of DNA repair R-HSA-9675135 1.237197e-01 0.908 0 0
Ub-specific processing proteases R-HSA-5689880 1.243932e-01 0.905 0 0
Regulation of KIT signaling R-HSA-1433559 1.256209e-01 0.901 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.270195e-01 0.896 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.332525e-01 0.875 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.332525e-01 0.875 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.332525e-01 0.875 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.337248e-01 0.874 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.354760e-01 0.868 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.355969e-01 0.868 0 0
Gap junction degradation R-HSA-190873 1.355969e-01 0.868 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.355969e-01 0.868 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.355969e-01 0.868 0 0
Hedgehog 'off' state R-HSA-5610787 1.360863e-01 0.866 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.362334e-01 0.866 0 0
G alpha (z) signalling events R-HSA-418597 1.362334e-01 0.866 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.362334e-01 0.866 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 1.905516e-01 0.720 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.905516e-01 0.720 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.905516e-01 0.720 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.905516e-01 0.720 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.905516e-01 0.720 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 1.905516e-01 0.720 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.905516e-01 0.720 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.905516e-01 0.720 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.905516e-01 0.720 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.905516e-01 0.720 0 0
IRS activation R-HSA-74713 1.697531e-01 0.770 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.602012e-01 0.795 0 0
2-LTR circle formation R-HSA-164843 1.602012e-01 0.795 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.860246e-01 0.730 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.860246e-01 0.730 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.860246e-01 0.730 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.442526e-01 0.841 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 1.844117e-01 0.734 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.606374e-01 0.794 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.405902e-01 0.852 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.405902e-01 0.852 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.057178e-01 0.687 0 0
Late endosomal microautophagy R-HSA-9615710 1.696110e-01 0.771 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.696110e-01 0.771 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.479679e-01 0.830 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.479679e-01 0.830 0 0
EGFR downregulation R-HSA-182971 2.008816e-01 0.697 0 0
Activation of GABAB receptors R-HSA-991365 1.644421e-01 0.784 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.884616e-01 0.725 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.640375e-01 0.785 0 0
EPH-Ephrin signaling R-HSA-2682334 1.982060e-01 0.703 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.382865e-01 0.859 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.382865e-01 0.859 0 0
Cellular response to hypoxia R-HSA-1234174 1.564543e-01 0.806 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.824402e-01 0.739 0 0
GABA B receptor activation R-HSA-977444 1.644421e-01 0.784 0 0
HSF1-dependent transactivation R-HSA-3371571 1.777013e-01 0.750 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.408339e-01 0.851 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.609802e-01 0.793 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.946434e-01 0.711 0 0
DCC mediated attractive signaling R-HSA-418885 1.442526e-01 0.841 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.028732e-01 0.693 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.764721e-01 0.753 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 1.860246e-01 0.730 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.606374e-01 0.794 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.744873e-01 0.758 0 0
RNA Polymerase III Transcription R-HSA-74158 1.744873e-01 0.758 0 0
mTORC1-mediated signalling R-HSA-166208 1.778194e-01 0.750 0 0
Signaling by EGFR R-HSA-177929 1.460236e-01 0.836 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.919984e-01 0.717 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.632699e-01 0.787 0 0
Regulation of CDH1 Function R-HSA-9764561 1.561639e-01 0.806 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.638859e-01 0.785 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.057178e-01 0.687 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.849857e-01 0.733 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.008816e-01 0.697 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.376584e-01 0.861 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.771151e-01 0.752 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.778194e-01 0.750 0 0
Signaling by MET R-HSA-6806834 1.466319e-01 0.834 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.696110e-01 0.771 0 0
Bicarbonate transporters R-HSA-425381 1.860246e-01 0.730 0 0
Signaling by APC mutants R-HSA-4839744 1.860246e-01 0.730 0 0
Negative regulation of FLT3 R-HSA-9706369 1.638859e-01 0.785 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.956544e-01 0.709 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.744873e-01 0.758 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.000039e-01 0.699 0 0
Generic Transcription Pathway R-HSA-212436 1.587228e-01 0.799 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.057290e-01 0.687 0 0
Integration of energy metabolism R-HSA-163685 1.405472e-01 0.852 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.470389e-01 0.833 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.602012e-01 0.795 0 0
Gap junction trafficking and regulation R-HSA-157858 1.549473e-01 0.810 0 0
Hemostasis R-HSA-109582 2.031735e-01 0.692 0 0
Gap junction trafficking R-HSA-190828 1.897356e-01 0.722 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.609802e-01 0.793 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.491896e-01 0.826 0 0
Syndecan interactions R-HSA-3000170 1.956544e-01 0.709 0 0
Potential therapeutics for SARS R-HSA-9679191 1.834595e-01 0.736 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 1.849857e-01 0.733 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.441720e-01 0.841 0 0
Growth hormone receptor signaling R-HSA-982772 1.956544e-01 0.709 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.460236e-01 0.836 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 1.697531e-01 0.770 0 0
Pentose phosphate pathway disease R-HSA-6791465 2.076548e-01 0.683 0 0
Phosphorylation of Emi1 R-HSA-176417 2.076548e-01 0.683 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 2.076548e-01 0.683 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 2.076548e-01 0.683 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.076548e-01 0.683 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.076548e-01 0.683 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.076548e-01 0.683 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.076548e-01 0.683 0 0
Death Receptor Signaling R-HSA-73887 2.122650e-01 0.673 0 0
Activation of RAC1 R-HSA-428540 2.128305e-01 0.672 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.128305e-01 0.672 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 2.128305e-01 0.672 0 0
Signaling by AXIN mutants R-HSA-4839735 2.128305e-01 0.672 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.128305e-01 0.672 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.128355e-01 0.672 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.140763e-01 0.669 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.165441e-01 0.664 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 2.165441e-01 0.664 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 2.165441e-01 0.664 0 0
Selenoamino acid metabolism R-HSA-2408522 2.220417e-01 0.654 0 0
Autophagy R-HSA-9612973 2.274244e-01 0.643 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.276903e-01 0.643 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.276903e-01 0.643 0 0
Platelet sensitization by LDL R-HSA-432142 2.276903e-01 0.643 0 0
Circadian clock R-HSA-9909396 2.278348e-01 0.642 0 0
SARS-CoV Infections R-HSA-9679506 2.287565e-01 0.641 0 0
Translation R-HSA-72766 2.304905e-01 0.637 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.328817e-01 0.633 0 0
Generation of second messenger molecules R-HSA-202433 2.328817e-01 0.633 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.328817e-01 0.633 0 0
TGFBR3 expression R-HSA-9839394 2.330168e-01 0.633 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.340593e-01 0.631 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.340593e-01 0.631 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.340593e-01 0.631 0 0
Ion transport by P-type ATPases R-HSA-936837 2.359529e-01 0.627 0 0
Macroautophagy R-HSA-1632852 2.388084e-01 0.622 0 0
Leading Strand Synthesis R-HSA-69109 2.403923e-01 0.619 0 0
Polymerase switching R-HSA-69091 2.403923e-01 0.619 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.403923e-01 0.619 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.403923e-01 0.619 0 0
Regulation of IFNG signaling R-HSA-877312 2.403923e-01 0.619 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.403923e-01 0.619 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.430313e-01 0.614 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.717518e-01 0.566 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 2.717518e-01 0.566 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.717518e-01 0.566 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.717518e-01 0.566 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.717518e-01 0.566 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.717518e-01 0.566 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.717518e-01 0.566 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 2.717518e-01 0.566 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.717518e-01 0.566 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.717518e-01 0.566 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.717518e-01 0.566 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.448106e-01 0.462 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.448106e-01 0.462 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.448106e-01 0.462 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.448106e-01 0.462 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.448106e-01 0.462 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.448106e-01 0.462 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.448106e-01 0.462 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.448106e-01 0.462 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.448106e-01 0.462 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.448106e-01 0.462 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.448106e-01 0.462 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.448106e-01 0.462 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.448106e-01 0.462 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.448106e-01 0.462 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.463097e-01 0.609 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.851858e-01 0.545 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.851858e-01 0.545 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.851858e-01 0.545 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.851858e-01 0.545 0 0
PTK6 Expression R-HSA-8849473 2.851858e-01 0.545 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.851858e-01 0.545 0 0
Axonal growth stimulation R-HSA-209563 4.105439e-01 0.387 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.105439e-01 0.387 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.105439e-01 0.387 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.105439e-01 0.387 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.105439e-01 0.387 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 4.105439e-01 0.387 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.105439e-01 0.387 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 4.105439e-01 0.387 0 0
Invadopodia formation R-HSA-8941237 4.105439e-01 0.387 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 4.105439e-01 0.387 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.105439e-01 0.387 0 0
MET activates PTPN11 R-HSA-8865999 4.105439e-01 0.387 0 0
MET receptor recycling R-HSA-8875656 3.238501e-01 0.490 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.238501e-01 0.490 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.238501e-01 0.490 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.502161e-01 0.602 0 0
Interleukin-21 signaling R-HSA-9020958 3.619540e-01 0.441 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.696859e-01 0.328 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.696859e-01 0.328 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 4.696859e-01 0.328 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.696859e-01 0.328 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 4.696859e-01 0.328 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.255436e-01 0.487 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.255436e-01 0.487 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.255436e-01 0.487 0 0
Lagging Strand Synthesis R-HSA-69186 2.964849e-01 0.528 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.992211e-01 0.399 0 0
Regulation of BACH1 activity R-HSA-9708530 3.541374e-01 0.451 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.541374e-01 0.451 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.200153e-01 0.495 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.200153e-01 0.495 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.642469e-01 0.578 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.825717e-01 0.417 0 0
PECAM1 interactions R-HSA-210990 4.354359e-01 0.361 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.354359e-01 0.361 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.354359e-01 0.361 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.354359e-01 0.361 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.330868e-01 0.477 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.330868e-01 0.477 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.673726e-01 0.435 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.228991e-01 0.491 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.910181e-01 0.408 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.704346e-01 0.328 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.704346e-01 0.328 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.704346e-01 0.328 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 4.704346e-01 0.328 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.597972e-01 0.444 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.597972e-01 0.444 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.950294e-01 0.403 0 0
HIV Transcription Elongation R-HSA-167169 3.783540e-01 0.422 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.783540e-01 0.422 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.783540e-01 0.422 0 0
snRNP Assembly R-HSA-191859 4.134587e-01 0.384 0 0
Metabolism of non-coding RNA R-HSA-194441 4.134587e-01 0.384 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.692123e-01 0.433 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.564228e-01 0.341 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.835602e-01 0.316 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.835602e-01 0.316 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.485070e-01 0.348 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.886151e-01 0.311 0 0
Neutrophil degranulation R-HSA-6798695 3.809313e-01 0.419 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.671202e-01 0.573 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 2.674910e-01 0.573 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.075701e-01 0.512 0 0
Downstream signal transduction R-HSA-186763 3.537025e-01 0.451 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.783540e-01 0.422 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.783540e-01 0.422 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.200153e-01 0.495 0 0
MET promotes cell motility R-HSA-8875878 3.412974e-01 0.467 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.524070e-01 0.598 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.299252e-01 0.482 0 0
DNA Damage Bypass R-HSA-73893 2.591734e-01 0.586 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 4.696859e-01 0.328 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.299252e-01 0.482 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.132261e-01 0.504 0 0
Interleukin-2 signaling R-HSA-9020558 4.354359e-01 0.361 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.619540e-01 0.441 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.255436e-01 0.487 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.316129e-01 0.365 0 0
Adipogenesis R-HSA-9843745 3.880037e-01 0.411 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.731837e-01 0.564 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.721773e-01 0.565 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.642469e-01 0.578 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.642469e-01 0.578 0 0
Attenuation phase R-HSA-3371568 3.783540e-01 0.422 0 0
Pyroptosis R-HSA-5620971 4.835602e-01 0.316 0 0
Activation of SMO R-HSA-5635838 3.541374e-01 0.451 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.886151e-01 0.311 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.717518e-01 0.566 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.619540e-01 0.441 0 0
Regulation of gap junction activity R-HSA-191650 4.696859e-01 0.328 0 0
RAF activation R-HSA-5673000 2.687751e-01 0.571 0 0
PKA activation R-HSA-163615 4.384429e-01 0.358 0 0
Proteasome assembly R-HSA-9907900 4.705535e-01 0.327 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.138628e-01 0.503 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.436758e-01 0.464 0 0
Nucleotide Excision Repair R-HSA-5696398 3.573980e-01 0.447 0 0
UCH proteinases R-HSA-5689603 3.965253e-01 0.402 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.953955e-01 0.530 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.953955e-01 0.530 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.953955e-01 0.530 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.953955e-01 0.530 0 0
Long-term potentiation R-HSA-9620244 4.145311e-01 0.382 0 0
Nuclear import of Rev protein R-HSA-180746 4.361068e-01 0.360 0 0
HSF1 activation R-HSA-3371511 4.765284e-01 0.322 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.813467e-01 0.551 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.316129e-01 0.365 0 0
Interleukin-9 signaling R-HSA-8985947 3.238501e-01 0.490 0 0
Cellular response to chemical stress R-HSA-9711123 2.810216e-01 0.551 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.684956e-01 0.571 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.731837e-01 0.564 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.783540e-01 0.422 0 0
GABA receptor activation R-HSA-977443 4.292200e-01 0.367 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.659989e-01 0.332 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.121208e-01 0.506 0 0
Platelet degranulation R-HSA-114608 2.511230e-01 0.600 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.410876e-01 0.467 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.255436e-01 0.487 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.409433e-01 0.467 0 0
HCMV Infection R-HSA-9609646 2.809093e-01 0.551 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.105439e-01 0.387 0 0
FasL/ CD95L signaling R-HSA-75157 4.105439e-01 0.387 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.696859e-01 0.328 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.696859e-01 0.328 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.673726e-01 0.435 0 0
HIV Life Cycle R-HSA-162587 3.092271e-01 0.510 0 0
Signal attenuation R-HSA-74749 3.992211e-01 0.399 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.619540e-01 0.441 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.825717e-01 0.417 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.274185e-01 0.485 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.138628e-01 0.503 0 0
Vesicle-mediated transport R-HSA-5653656 3.704992e-01 0.431 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.953955e-01 0.530 0 0
Nuclear RNA decay R-HSA-9930044 3.950294e-01 0.403 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.446758e-01 0.611 0 0
Interferon Signaling R-HSA-913531 4.411536e-01 0.355 0 0
HIV Infection R-HSA-162906 4.564692e-01 0.341 0 0
MAPK family signaling cascades R-HSA-5683057 3.224286e-01 0.492 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.717518e-01 0.566 0 0
Interleukin-33 signaling R-HSA-9014843 3.448106e-01 0.462 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.448106e-01 0.462 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.448106e-01 0.462 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.448106e-01 0.462 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.851858e-01 0.545 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.105439e-01 0.387 0 0
MET interacts with TNS proteins R-HSA-8875513 4.105439e-01 0.387 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.238501e-01 0.490 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.238501e-01 0.490 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.696859e-01 0.328 0 0
GABA synthesis R-HSA-888568 4.696859e-01 0.328 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 2.964849e-01 0.528 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.992211e-01 0.399 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.541374e-01 0.451 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.200153e-01 0.495 0 0
Insulin receptor recycling R-HSA-77387 2.922591e-01 0.534 0 0
Disorders of Developmental Biology R-HSA-9675151 3.825717e-01 0.417 0 0
NF-kB is activated and signals survival R-HSA-209560 4.704346e-01 0.328 0 0
PKA activation in glucagon signalling R-HSA-164378 4.384429e-01 0.358 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.384429e-01 0.358 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.348905e-01 0.475 0 0
TCR signaling R-HSA-202403 3.137412e-01 0.503 0 0
Degradation of CDH1 R-HSA-9766229 3.976540e-01 0.400 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.835602e-01 0.316 0 0
Signaling by Interleukins R-HSA-449147 3.395203e-01 0.469 0 0
Surfactant metabolism R-HSA-5683826 4.705535e-01 0.327 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.548522e-01 0.594 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.761567e-01 0.322 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.712741e-01 0.567 0 0
Smooth Muscle Contraction R-HSA-445355 3.194090e-01 0.496 0 0
Interleukin-1 family signaling R-HSA-446652 2.658770e-01 0.575 0 0
Hedgehog 'on' state R-HSA-5632684 3.274185e-01 0.485 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.803513e-01 0.552 0 0
Platelet homeostasis R-HSA-418346 2.717018e-01 0.566 0 0
Transmission across Chemical Synapses R-HSA-112315 4.728036e-01 0.325 0 0
Muscle contraction R-HSA-397014 4.885166e-01 0.311 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.851858e-01 0.545 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.238501e-01 0.490 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.696859e-01 0.328 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.255436e-01 0.487 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.378367e-01 0.359 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.436715e-01 0.353 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.743697e-01 0.427 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.656602e-01 0.332 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.537025e-01 0.451 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.463097e-01 0.609 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.105439e-01 0.387 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.619540e-01 0.441 0 0
Josephin domain DUBs R-HSA-5689877 3.992211e-01 0.399 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 3.910181e-01 0.408 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.704346e-01 0.328 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.597972e-01 0.444 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.783540e-01 0.422 0 0
Semaphorin interactions R-HSA-373755 3.384748e-01 0.470 0 0
Signaling by TGFB family members R-HSA-9006936 4.223203e-01 0.374 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.825887e-01 0.417 0 0
Signaling by PTK6 R-HSA-8848021 4.761567e-01 0.322 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.761567e-01 0.322 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.255436e-01 0.487 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.992211e-01 0.399 0 0
Suppression of apoptosis R-HSA-9635465 4.354359e-01 0.361 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.378367e-01 0.359 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.608669e-01 0.336 0 0
Signaling by NTRKs R-HSA-166520 4.886006e-01 0.311 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.255436e-01 0.487 0 0
Cytoprotection by HMOX1 R-HSA-9707564 3.691774e-01 0.433 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.886151e-01 0.311 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.886151e-01 0.311 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.105439e-01 0.387 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.619540e-01 0.441 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.541374e-01 0.451 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.950294e-01 0.403 0 0
Signaling by NOTCH4 R-HSA-9013694 3.686913e-01 0.433 0 0
p75NTR signals via NF-kB R-HSA-193639 3.255436e-01 0.487 0 0
Maturation of nucleoprotein R-HSA-9694631 2.502161e-01 0.602 0 0
Toxicity of tetanus toxin (tetX) R-HSA-5250982 4.696859e-01 0.328 0 0
LGI-ADAM interactions R-HSA-5682910 4.354359e-01 0.361 0 0
Signaling by ALK R-HSA-201556 3.597972e-01 0.444 0 0
Gap junction assembly R-HSA-190861 4.361068e-01 0.360 0 0
G1/S-Specific Transcription R-HSA-69205 3.046480e-01 0.516 0 0
Other interleukin signaling R-HSA-449836 2.502161e-01 0.602 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.339461e-01 0.363 0 0
Signaling by Leptin R-HSA-2586552 3.992211e-01 0.399 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.354359e-01 0.361 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.378367e-01 0.359 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.354359e-01 0.361 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.964849e-01 0.528 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.464040e-01 0.608 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.916119e-01 0.308 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.922772e-01 0.308 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.922772e-01 0.308 0 0
Formation of definitive endoderm R-HSA-9823730 4.922772e-01 0.308 0 0
Protein hydroxylation R-HSA-9629569 4.922772e-01 0.308 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.963816e-01 0.304 0 0
Signaling by NOTCH3 R-HSA-9012852 4.985121e-01 0.302 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.040967e-01 0.297 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.040967e-01 0.297 0 0
Interleukin-15 signaling R-HSA-8983432 5.040967e-01 0.297 0 0
Repression of WNT target genes R-HSA-4641265 5.040967e-01 0.297 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.040967e-01 0.297 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 5.040967e-01 0.297 0 0
Disorders of Nervous System Development R-HSA-9697154 5.040967e-01 0.297 0 0
Pervasive developmental disorders R-HSA-9005895 5.040967e-01 0.297 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.040967e-01 0.297 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 5.040967e-01 0.297 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 5.040967e-01 0.297 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.040967e-01 0.297 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.058617e-01 0.296 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.064733e-01 0.295 0 0
Glycolysis R-HSA-70171 5.077430e-01 0.294 0 0
Parasitic Infection Pathways R-HSA-9824443 5.109412e-01 0.292 0 0
Leishmania infection R-HSA-9658195 5.109412e-01 0.292 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.159440e-01 0.287 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.182202e-01 0.285 0 0
Rab regulation of trafficking R-HSA-9007101 5.195135e-01 0.284 0 0
Mitochondrial biogenesis R-HSA-1592230 5.195135e-01 0.284 0 0
Interleukin-1 signaling R-HSA-9020702 5.200706e-01 0.284 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.221211e-01 0.282 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.228971e-01 0.282 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.228971e-01 0.282 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.228971e-01 0.282 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.228971e-01 0.282 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.228971e-01 0.282 0 0
PTK6 Down-Regulation R-HSA-8849472 5.228971e-01 0.282 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.228971e-01 0.282 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.228971e-01 0.282 0 0
Activation of C3 and C5 R-HSA-174577 5.228971e-01 0.282 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.228971e-01 0.282 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.228971e-01 0.282 0 0
Reelin signalling pathway R-HSA-8866376 5.228971e-01 0.282 0 0
Inositol transporters R-HSA-429593 5.228971e-01 0.282 0 0
Interleukin-36 pathway R-HSA-9014826 5.228971e-01 0.282 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.228971e-01 0.282 0 0
Co-inhibition by BTLA R-HSA-9927353 5.228971e-01 0.282 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.228971e-01 0.282 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 5.228971e-01 0.282 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.228971e-01 0.282 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.228971e-01 0.282 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.228971e-01 0.282 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.240996e-01 0.281 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.240996e-01 0.281 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.256547e-01 0.279 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.256547e-01 0.279 0 0
Ion channel transport R-HSA-983712 5.275852e-01 0.278 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.277228e-01 0.278 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.277228e-01 0.278 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.277228e-01 0.278 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.342937e-01 0.272 0 0
Interleukin-6 signaling R-HSA-1059683 5.363381e-01 0.271 0 0
Frs2-mediated activation R-HSA-170968 5.363381e-01 0.271 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.363381e-01 0.271 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.363381e-01 0.271 0 0
Intraflagellar transport R-HSA-5620924 5.414674e-01 0.266 0 0
Co-stimulation by CD28 R-HSA-389356 5.414674e-01 0.266 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.425866e-01 0.266 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.434286e-01 0.265 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.434286e-01 0.265 0 0
Trafficking of AMPA receptors R-HSA-399719 5.491010e-01 0.260 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.491010e-01 0.260 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.491010e-01 0.260 0 0
Transcription of the HIV genome R-HSA-167172 5.519463e-01 0.258 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.540611e-01 0.256 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.540611e-01 0.256 0 0
Diseases of Immune System R-HSA-5260271 5.540611e-01 0.256 0 0
Neuronal System R-HSA-112316 5.579251e-01 0.253 0 0
Removal of the Flap Intermediate R-HSA-69166 5.671050e-01 0.246 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.671050e-01 0.246 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.671050e-01 0.246 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.671050e-01 0.246 0 0
Prolactin receptor signaling R-HSA-1170546 5.671050e-01 0.246 0 0
P2Y receptors R-HSA-417957 5.671050e-01 0.246 0 0
HDL assembly R-HSA-8963896 5.671050e-01 0.246 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.678531e-01 0.246 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.678531e-01 0.246 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.678531e-01 0.246 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 5.678531e-01 0.246 0 0
RSV-host interactions R-HSA-9833110 5.683665e-01 0.245 0 0
Signaling by WNT in cancer R-HSA-4791275 5.699599e-01 0.244 0 0
Developmental Biology R-HSA-1266738 5.700499e-01 0.244 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.704396e-01 0.244 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.707719e-01 0.244 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.707719e-01 0.244 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.707719e-01 0.244 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.707719e-01 0.244 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.707719e-01 0.244 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.707719e-01 0.244 0 0
TRAIL signaling R-HSA-75158 5.707719e-01 0.244 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 5.707719e-01 0.244 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.707719e-01 0.244 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.707719e-01 0.244 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.707719e-01 0.244 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.707719e-01 0.244 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.707719e-01 0.244 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.707719e-01 0.244 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.707719e-01 0.244 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.707719e-01 0.244 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.707719e-01 0.244 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.707719e-01 0.244 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.725568e-01 0.242 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.725568e-01 0.242 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.725568e-01 0.242 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.725568e-01 0.242 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.769811e-01 0.239 0 0
tRNA Aminoacylation R-HSA-379724 5.781617e-01 0.238 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.809804e-01 0.236 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 5.831758e-01 0.234 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.902685e-01 0.229 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.902685e-01 0.229 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.902685e-01 0.229 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.906435e-01 0.229 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.906435e-01 0.229 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.917912e-01 0.228 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.933575e-01 0.227 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.951620e-01 0.225 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.963688e-01 0.224 0 0
Protein lipoylation R-HSA-9857492 5.963688e-01 0.224 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.963688e-01 0.224 0 0
DNA Damage Reversal R-HSA-73942 5.963688e-01 0.224 0 0
Host Interactions of HIV factors R-HSA-162909 5.968290e-01 0.224 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.971042e-01 0.224 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.011882e-01 0.221 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.011882e-01 0.221 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.011882e-01 0.221 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.079072e-01 0.216 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.079072e-01 0.216 0 0
Signaling by PDGF R-HSA-186797 6.082711e-01 0.216 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.083002e-01 0.216 0 0
Striated Muscle Contraction R-HSA-390522 6.100012e-01 0.215 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.100012e-01 0.215 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.100012e-01 0.215 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.100012e-01 0.215 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.100012e-01 0.215 0 0
FOXO-mediated transcription R-HSA-9614085 6.130453e-01 0.213 0 0
Signaling by LTK in cancer R-HSA-9842640 6.138453e-01 0.212 0 0
Chylomicron clearance R-HSA-8964026 6.138453e-01 0.212 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.138453e-01 0.212 0 0
Defective CYP11A1 causes AICSR R-HSA-5579026 6.138453e-01 0.212 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.138453e-01 0.212 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.138453e-01 0.212 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.138453e-01 0.212 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.138453e-01 0.212 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.138453e-01 0.212 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.138453e-01 0.212 0 0
CREB phosphorylation R-HSA-199920 6.138453e-01 0.212 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.138453e-01 0.212 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.138453e-01 0.212 0 0
Nef and signal transduction R-HSA-164944 6.138453e-01 0.212 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.138453e-01 0.212 0 0
Neurofascin interactions R-HSA-447043 6.138453e-01 0.212 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.142071e-01 0.212 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.142071e-01 0.212 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.204769e-01 0.207 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.241212e-01 0.205 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.241212e-01 0.205 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.241212e-01 0.205 0 0
Prolonged ERK activation events R-HSA-169893 6.241212e-01 0.205 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.241212e-01 0.205 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.241212e-01 0.205 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.255088e-01 0.204 0 0
TBC/RABGAPs R-HSA-8854214 6.255088e-01 0.204 0 0
Signaling by SCF-KIT R-HSA-1433557 6.255088e-01 0.204 0 0
Dual Incision in GG-NER R-HSA-5696400 6.291374e-01 0.201 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.291374e-01 0.201 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.360881e-01 0.196 0 0
Tight junction interactions R-HSA-420029 6.360881e-01 0.196 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.360881e-01 0.196 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.383298e-01 0.195 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.398307e-01 0.194 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.422544e-01 0.192 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.476611e-01 0.189 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 6.476611e-01 0.189 0 0
PERK regulates gene expression R-HSA-381042 6.476611e-01 0.189 0 0
Transferrin endocytosis and recycling R-HSA-917977 6.476611e-01 0.189 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.493767e-01 0.188 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.503708e-01 0.187 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.503708e-01 0.187 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.503708e-01 0.187 0 0
Synthesis of PG R-HSA-1483148 6.503708e-01 0.187 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.525985e-01 0.185 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.525985e-01 0.185 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.525985e-01 0.185 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.525985e-01 0.185 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.525985e-01 0.185 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.525985e-01 0.185 0 0
SOS-mediated signalling R-HSA-112412 6.525985e-01 0.185 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.525985e-01 0.185 0 0
Recycling of eIF2:GDP R-HSA-72731 6.525985e-01 0.185 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.525985e-01 0.185 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.525985e-01 0.185 0 0
Electron transport from NADPH to Ferredoxin R-HSA-2395516 6.525985e-01 0.185 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.525985e-01 0.185 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.525985e-01 0.185 0 0
VLDL clearance R-HSA-8964046 6.525985e-01 0.185 0 0
Regulation of PTEN localization R-HSA-8948747 6.525985e-01 0.185 0 0
CHL1 interactions R-HSA-447041 6.525985e-01 0.185 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.570863e-01 0.182 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.570863e-01 0.182 0 0
Metalloprotease DUBs R-HSA-5689901 6.570863e-01 0.182 0 0
TRP channels R-HSA-3295583 6.570863e-01 0.182 0 0
Adaptive Immune System R-HSA-1280218 6.572546e-01 0.182 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.587587e-01 0.181 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.604936e-01 0.180 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 6.655605e-01 0.177 0 0
Triglyceride catabolism R-HSA-163560 6.655605e-01 0.177 0 0
FLT3 signaling in disease R-HSA-9682385 6.655605e-01 0.177 0 0
HCMV Late Events R-HSA-9610379 6.687061e-01 0.175 0 0
Signaling by TGFBR3 R-HSA-9839373 6.743100e-01 0.171 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.751398e-01 0.171 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.751398e-01 0.171 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.751398e-01 0.171 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.751398e-01 0.171 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.751398e-01 0.171 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.771967e-01 0.169 0 0
Cristae formation R-HSA-8949613 6.771967e-01 0.169 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.771967e-01 0.169 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.771967e-01 0.169 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.771967e-01 0.169 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.774048e-01 0.169 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.828279e-01 0.166 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.828279e-01 0.166 0 0
Cardiac conduction R-HSA-5576891 6.872326e-01 0.163 0 0
Regulation by c-FLIP R-HSA-3371378 6.874647e-01 0.163 0 0
RSK activation R-HSA-444257 6.874647e-01 0.163 0 0
Dimerization of procaspase-8 R-HSA-69416 6.874647e-01 0.163 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.874647e-01 0.163 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.874647e-01 0.163 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.874647e-01 0.163 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.874647e-01 0.163 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.874647e-01 0.163 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.874647e-01 0.163 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 6.874647e-01 0.163 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.896035e-01 0.161 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.928818e-01 0.159 0 0
Potassium Channels R-HSA-1296071 6.928818e-01 0.159 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.964203e-01 0.157 0 0
GAB1 signalosome R-HSA-180292 6.984609e-01 0.156 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.984609e-01 0.156 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.984609e-01 0.156 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.984609e-01 0.156 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.984609e-01 0.156 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 6.984609e-01 0.156 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.984609e-01 0.156 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.991708e-01 0.155 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.994590e-01 0.155 0 0
Toll-like Receptor Cascades R-HSA-168898 7.096826e-01 0.149 0 0
Regulation of beta-cell development R-HSA-186712 7.101252e-01 0.149 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.131871e-01 0.147 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.131871e-01 0.147 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.147632e-01 0.146 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.147632e-01 0.146 0 0
Signaling by Erythropoietin R-HSA-9006335 7.147632e-01 0.146 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.147632e-01 0.146 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.154530e-01 0.145 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.154530e-01 0.145 0 0
Stabilization of p53 R-HSA-69541 7.154530e-01 0.145 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.154530e-01 0.145 0 0
Downstream TCR signaling R-HSA-202424 7.176883e-01 0.144 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.186982e-01 0.143 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.186982e-01 0.143 0 0
CASP8 activity is inhibited R-HSA-5218900 7.188334e-01 0.143 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.188334e-01 0.143 0 0
Calcineurin activates NFAT R-HSA-2025928 7.188334e-01 0.143 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 7.188334e-01 0.143 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.188334e-01 0.143 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.188334e-01 0.143 0 0
ARMS-mediated activation R-HSA-170984 7.188334e-01 0.143 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.188334e-01 0.143 0 0
WNT mediated activation of DVL R-HSA-201688 7.188334e-01 0.143 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.188334e-01 0.143 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.188334e-01 0.143 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.188334e-01 0.143 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.188334e-01 0.143 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.188334e-01 0.143 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.188334e-01 0.143 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.203752e-01 0.142 0 0
Regulation of signaling by CBL R-HSA-912631 7.203752e-01 0.142 0 0
Translesion Synthesis by POLH R-HSA-110320 7.203752e-01 0.142 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.203752e-01 0.142 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.203752e-01 0.142 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.210625e-01 0.142 0 0
Glucose metabolism R-HSA-70326 7.277674e-01 0.138 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.307106e-01 0.136 0 0
Interleukin-2 family signaling R-HSA-451927 7.308118e-01 0.136 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.308118e-01 0.136 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.308118e-01 0.136 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.322362e-01 0.135 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.322362e-01 0.135 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.322362e-01 0.135 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.324963e-01 0.135 0 0
MAP kinase activation R-HSA-450294 7.357062e-01 0.133 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.368989e-01 0.133 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.397158e-01 0.131 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 7.397158e-01 0.131 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.409301e-01 0.130 0 0
Glycogen synthesis R-HSA-3322077 7.409301e-01 0.130 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.470554e-01 0.127 0 0
DNA replication initiation R-HSA-68952 7.470554e-01 0.127 0 0
PI3K/AKT activation R-HSA-198203 7.470554e-01 0.127 0 0
Binding and entry of HIV virion R-HSA-173107 7.470554e-01 0.127 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.470554e-01 0.127 0 0
Interleukin-27 signaling R-HSA-9020956 7.470554e-01 0.127 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.470554e-01 0.127 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.470554e-01 0.127 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.470554e-01 0.127 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.470554e-01 0.127 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.470554e-01 0.127 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.470554e-01 0.127 0 0
tRNA processing in the nucleus R-HSA-6784531 7.478783e-01 0.126 0 0
Budding and maturation of HIV virion R-HSA-162588 7.488542e-01 0.126 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.488542e-01 0.126 0 0
Inositol phosphate metabolism R-HSA-1483249 7.583253e-01 0.120 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.596451e-01 0.119 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.601777e-01 0.119 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.601777e-01 0.119 0 0
ERK/MAPK targets R-HSA-198753 7.601777e-01 0.119 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.601777e-01 0.119 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.601777e-01 0.119 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.646352e-01 0.117 0 0
Interferon gamma signaling R-HSA-877300 7.670402e-01 0.115 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.670842e-01 0.115 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.709130e-01 0.113 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.709130e-01 0.113 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.709130e-01 0.113 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.713865e-01 0.113 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.713865e-01 0.113 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.724216e-01 0.112 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.724460e-01 0.112 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.724460e-01 0.112 0 0
vRNA Synthesis R-HSA-192814 7.724460e-01 0.112 0 0
Synthesis of PI R-HSA-1483226 7.724460e-01 0.112 0 0
Transport of RCbl within the body R-HSA-9758890 7.724460e-01 0.112 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.724460e-01 0.112 0 0
Chylomicron assembly R-HSA-8963888 7.724460e-01 0.112 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.724460e-01 0.112 0 0
Prostanoid ligand receptors R-HSA-391908 7.724460e-01 0.112 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.774702e-01 0.109 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.781732e-01 0.109 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.781732e-01 0.109 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.781732e-01 0.109 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.781732e-01 0.109 0 0
Ribavirin ADME R-HSA-9755088 7.781732e-01 0.109 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.795998e-01 0.108 0 0
Signaling by FGFR4 R-HSA-5654743 7.860227e-01 0.105 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.860227e-01 0.105 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.920225e-01 0.101 0 0
Vpu mediated degradation of CD4 R-HSA-180534 7.937710e-01 0.100 0 0
FGFR2 alternative splicing R-HSA-6803529 7.949740e-01 0.100 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.949740e-01 0.100 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.949740e-01 0.100 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.949740e-01 0.100 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.949740e-01 0.100 0 0
LDL clearance R-HSA-8964038 7.949740e-01 0.100 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.952893e-01 0.099 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.952893e-01 0.099 0 0
ERKs are inactivated R-HSA-202670 7.952893e-01 0.099 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.952893e-01 0.099 0 0
G1 Phase R-HSA-69236 7.983187e-01 0.098 0 0
Cyclin D associated events in G1 R-HSA-69231 7.983187e-01 0.098 0 0
Netrin-1 signaling R-HSA-373752 7.983187e-01 0.098 0 0
ABC transporter disorders R-HSA-5619084 8.020021e-01 0.096 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.049702e-01 0.094 0 0
Signaling by FGFR1 R-HSA-5654736 8.049702e-01 0.094 0 0
TNF signaling R-HSA-75893 8.049702e-01 0.094 0 0
Signaling by NOTCH2 R-HSA-1980145 8.071737e-01 0.093 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.071737e-01 0.093 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.071737e-01 0.093 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.071737e-01 0.093 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.071737e-01 0.093 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.071737e-01 0.093 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.100374e-01 0.091 0 0
Signaling by FGFR3 R-HSA-5654741 8.100374e-01 0.091 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.100374e-01 0.091 0 0
Somitogenesis R-HSA-9824272 8.100374e-01 0.091 0 0
Interleukin-20 family signaling R-HSA-8854691 8.106386e-01 0.091 0 0
Regulated Necrosis R-HSA-5218859 8.123979e-01 0.090 0 0
Infectious disease R-HSA-5663205 8.155308e-01 0.089 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.158407e-01 0.088 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.158407e-01 0.088 0 0
Interleukin-35 Signalling R-HSA-8984722 8.158407e-01 0.088 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.158407e-01 0.088 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.158407e-01 0.088 0 0
Signaling by LTK R-HSA-9842663 8.158407e-01 0.088 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.158407e-01 0.088 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.158407e-01 0.088 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.158407e-01 0.088 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.158407e-01 0.088 0 0
Metallothioneins bind metals R-HSA-5661231 8.158407e-01 0.088 0 0
OAS antiviral response R-HSA-8983711 8.158407e-01 0.088 0 0
Neurotransmitter release cycle R-HSA-112310 8.195174e-01 0.086 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 8.195174e-01 0.086 0 0
Oncogene Induced Senescence R-HSA-2559585 8.198340e-01 0.086 0 0
Signalling to ERKs R-HSA-187687 8.198340e-01 0.086 0 0
Regulation of Apoptosis R-HSA-169911 8.198340e-01 0.086 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.211937e-01 0.086 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.252258e-01 0.083 0 0
Interleukin-6 family signaling R-HSA-6783589 8.252258e-01 0.083 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.252258e-01 0.083 0 0
ABC-family proteins mediated transport R-HSA-382556 8.275457e-01 0.082 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.301773e-01 0.081 0 0
Interleukin-17 signaling R-HSA-448424 8.307785e-01 0.081 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.318033e-01 0.080 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.343300e-01 0.079 0 0
Chylomicron remodeling R-HSA-8963901 8.343300e-01 0.079 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.343300e-01 0.079 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.343300e-01 0.079 0 0
Processing of SMDT1 R-HSA-8949664 8.343300e-01 0.079 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.343300e-01 0.079 0 0
Formation of axial mesoderm R-HSA-9796292 8.343300e-01 0.079 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.343300e-01 0.079 0 0
Maturation of nucleoprotein R-HSA-9683610 8.343300e-01 0.079 0 0
Extension of Telomeres R-HSA-180786 8.348830e-01 0.078 0 0
Triglyceride metabolism R-HSA-8979227 8.348830e-01 0.078 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.387938e-01 0.076 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.387938e-01 0.076 0 0
Signaling by Insulin receptor R-HSA-74752 8.429223e-01 0.074 0 0
Degradation of DVL R-HSA-4641258 8.430367e-01 0.074 0 0
Degradation of AXIN R-HSA-4641257 8.430367e-01 0.074 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.509639e-01 0.070 0 0
cGMP effects R-HSA-418457 8.509639e-01 0.070 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.509639e-01 0.070 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.509639e-01 0.070 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.509639e-01 0.070 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.509639e-01 0.070 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.509639e-01 0.070 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.509639e-01 0.070 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.509639e-01 0.070 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.509639e-01 0.070 0 0
Zinc transporters R-HSA-435354 8.509639e-01 0.070 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.514003e-01 0.070 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.514003e-01 0.070 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.514003e-01 0.070 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.514003e-01 0.070 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.514003e-01 0.070 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.514494e-01 0.070 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.526603e-01 0.069 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.536352e-01 0.069 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.596074e-01 0.066 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.596074e-01 0.066 0 0
Azathioprine ADME R-HSA-9748787 8.605205e-01 0.065 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.631016e-01 0.064 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.631016e-01 0.064 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.631016e-01 0.064 0 0
Insulin processing R-HSA-264876 8.631016e-01 0.064 0 0
Signaling by ERBB4 R-HSA-1236394 8.631937e-01 0.064 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.636030e-01 0.064 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.636030e-01 0.064 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.645983e-01 0.063 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.659286e-01 0.063 0 0
Erythropoietin activates RAS R-HSA-9027284 8.659286e-01 0.063 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.659286e-01 0.063 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.659286e-01 0.063 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.659286e-01 0.063 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.659286e-01 0.063 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.659286e-01 0.063 0 0
Translesion synthesis by REV1 R-HSA-110312 8.659286e-01 0.063 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.659286e-01 0.063 0 0
p38MAPK events R-HSA-171007 8.659286e-01 0.063 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.659286e-01 0.063 0 0
Other semaphorin interactions R-HSA-416700 8.659286e-01 0.063 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.688154e-01 0.061 0 0
Iron uptake and transport R-HSA-917937 8.704428e-01 0.060 0 0
Glycogen metabolism R-HSA-8982491 8.729685e-01 0.059 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.729685e-01 0.059 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.739522e-01 0.059 0 0
Translesion synthesis by POLI R-HSA-5656121 8.793915e-01 0.056 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.793915e-01 0.056 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.793915e-01 0.056 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.793915e-01 0.056 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.793915e-01 0.056 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.793915e-01 0.056 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.793915e-01 0.056 0 0
Attachment and Entry R-HSA-9678110 8.793915e-01 0.056 0 0
Atorvastatin ADME R-HSA-9754706 8.793915e-01 0.056 0 0
Virus Assembly and Release R-HSA-168268 8.793915e-01 0.056 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.817600e-01 0.055 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.840049e-01 0.054 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.840049e-01 0.054 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.840049e-01 0.054 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 8.840049e-01 0.054 0 0
Platelet calcium homeostasis R-HSA-418360 8.840049e-01 0.054 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.840049e-01 0.054 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.857568e-01 0.053 0 0
Stimuli-sensing channels R-HSA-2672351 8.857568e-01 0.053 0 0
Signaling by FGFR1 in disease R-HSA-5655302 8.900052e-01 0.051 0 0
Scavenging by Class A Receptors R-HSA-3000480 8.900052e-01 0.051 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.902890e-01 0.050 0 0
Integrin cell surface interactions R-HSA-216083 8.902890e-01 0.050 0 0
PCP/CE pathway R-HSA-4086400 8.902890e-01 0.050 0 0
Translesion synthesis by POLK R-HSA-5655862 8.915032e-01 0.050 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.915032e-01 0.050 0 0
Glycine degradation R-HSA-6783984 8.915032e-01 0.050 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.915032e-01 0.050 0 0
Passive transport by Aquaporins R-HSA-432047 8.915032e-01 0.050 0 0
Coenzyme A biosynthesis R-HSA-196783 8.915032e-01 0.050 0 0
Response to metal ions R-HSA-5660526 8.915032e-01 0.050 0 0
ER-Phagosome pathway R-HSA-1236974 8.915918e-01 0.050 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.942602e-01 0.049 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.942602e-01 0.049 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.963031e-01 0.048 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.996321e-01 0.046 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.019179e-01 0.045 0 0
Cargo concentration in the ER R-HSA-5694530 9.019179e-01 0.045 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.019179e-01 0.045 0 0
Signaling by FGFR2 R-HSA-5654738 9.020330e-01 0.045 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.023993e-01 0.045 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.023993e-01 0.045 0 0
Glycogen storage diseases R-HSA-3229121 9.023993e-01 0.045 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.023993e-01 0.045 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.023993e-01 0.045 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.023993e-01 0.045 0 0
Uptake and function of anthrax toxins R-HSA-5210891 9.023993e-01 0.045 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.049655e-01 0.043 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.051845e-01 0.043 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.085550e-01 0.042 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.098732e-01 0.041 0 0
Protein localization R-HSA-9609507 9.121708e-01 0.040 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.122017e-01 0.040 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.122017e-01 0.040 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.122017e-01 0.040 0 0
Apoptotic factor-mediated response R-HSA-111471 9.122017e-01 0.040 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.122017e-01 0.040 0 0
COPII-mediated vesicle transport R-HSA-204005 9.140401e-01 0.039 0 0
FGFR1 mutant receptor activation R-HSA-1839124 9.172205e-01 0.038 0 0
Cardiogenesis R-HSA-9733709 9.172205e-01 0.038 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.172205e-01 0.038 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.172780e-01 0.037 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.210201e-01 0.036 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.210201e-01 0.036 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.210201e-01 0.036 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.210201e-01 0.036 0 0
Specification of the neural plate border R-HSA-9834899 9.210201e-01 0.036 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.210201e-01 0.036 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.210201e-01 0.036 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.210201e-01 0.036 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.210201e-01 0.036 0 0
HDL remodeling R-HSA-8964058 9.210201e-01 0.036 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.210201e-01 0.036 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.239703e-01 0.034 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.239703e-01 0.034 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.240017e-01 0.034 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.240017e-01 0.034 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 9.241481e-01 0.034 0 0
RAB geranylgeranylation R-HSA-8873719 9.279015e-01 0.032 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.289533e-01 0.032 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.289533e-01 0.032 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.289533e-01 0.032 0 0
Pregnenolone biosynthesis R-HSA-196108 9.289533e-01 0.032 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.289533e-01 0.032 0 0
Creatine metabolism R-HSA-71288 9.289533e-01 0.032 0 0
Signal transduction by L1 R-HSA-445144 9.289533e-01 0.032 0 0
Signaling by NODAL R-HSA-1181150 9.289533e-01 0.032 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.289533e-01 0.032 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.302564e-01 0.031 0 0
eNOS activation R-HSA-203615 9.302564e-01 0.031 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.302564e-01 0.031 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.302564e-01 0.031 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.326881e-01 0.030 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.331869e-01 0.030 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.350002e-01 0.029 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.360901e-01 0.029 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.360901e-01 0.029 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.360901e-01 0.029 0 0
Signalling to RAS R-HSA-167044 9.360901e-01 0.029 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.360901e-01 0.029 0 0
Basigin interactions R-HSA-210991 9.360901e-01 0.029 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.370723e-01 0.028 0 0
G alpha (s) signalling events R-HSA-418555 9.371652e-01 0.028 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.371851e-01 0.028 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.371851e-01 0.028 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.404130e-01 0.027 0 0
Signaling by FGFR R-HSA-190236 9.410031e-01 0.026 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.413332e-01 0.026 0 0
GPVI-mediated activation cascade R-HSA-114604 9.413332e-01 0.026 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.413332e-01 0.026 0 0
RUNX2 regulates bone development R-HSA-8941326 9.413332e-01 0.026 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.425103e-01 0.026 0 0
Attachment and Entry R-HSA-9694614 9.425103e-01 0.026 0 0
Immune System R-HSA-168256 9.443718e-01 0.025 0 0
Translation of Structural Proteins R-HSA-9694635 9.449433e-01 0.025 0 0
Voltage gated Potassium channels R-HSA-1296072 9.462236e-01 0.024 0 0
The phototransduction cascade R-HSA-2514856 9.480643e-01 0.023 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.482859e-01 0.023 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.482859e-01 0.023 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.482859e-01 0.023 0 0
Ethanol oxidation R-HSA-71384 9.482859e-01 0.023 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.482859e-01 0.023 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.507238e-01 0.022 0 0
Elastic fibre formation R-HSA-1566948 9.507238e-01 0.022 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.525666e-01 0.021 0 0
PI Metabolism R-HSA-1483255 9.532636e-01 0.021 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.534816e-01 0.021 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.534816e-01 0.021 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.534816e-01 0.021 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.534816e-01 0.021 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.534816e-01 0.021 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.534816e-01 0.021 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.534816e-01 0.021 0 0
Carnitine shuttle R-HSA-200425 9.534816e-01 0.021 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 9.534816e-01 0.021 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.548630e-01 0.020 0 0
Pentose phosphate pathway R-HSA-71336 9.548630e-01 0.020 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.569902e-01 0.019 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.577258e-01 0.019 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.581555e-01 0.019 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.586682e-01 0.018 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.621647e-01 0.017 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.623601e-01 0.017 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.623601e-01 0.017 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.623601e-01 0.017 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.623601e-01 0.017 0 0
Formation of the nephric duct R-HSA-9830364 9.623601e-01 0.017 0 0
Laminin interactions R-HSA-3000157 9.623601e-01 0.017 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.630156e-01 0.016 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.653762e-01 0.015 0 0
HIV Transcription Initiation R-HSA-167161 9.653762e-01 0.015 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.653762e-01 0.015 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.653762e-01 0.015 0 0
MET activates PTK2 signaling R-HSA-8874081 9.661424e-01 0.015 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.661424e-01 0.015 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.661424e-01 0.015 0 0
Sphingolipid catabolism R-HSA-9845614 9.661424e-01 0.015 0 0
Synthesis of PA R-HSA-1483166 9.675650e-01 0.014 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.683245e-01 0.014 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.683245e-01 0.014 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.684327e-01 0.014 0 0
Leishmania phagocytosis R-HSA-9664417 9.684327e-01 0.014 0 0
Parasite infection R-HSA-9664407 9.684327e-01 0.014 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.689744e-01 0.014 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.695449e-01 0.013 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 9.695449e-01 0.013 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.695449e-01 0.013 0 0
Triglyceride biosynthesis R-HSA-75109 9.695449e-01 0.013 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.695449e-01 0.013 0 0
Synthesis of PE R-HSA-1483213 9.695449e-01 0.013 0 0
Signaling by BMP R-HSA-201451 9.695449e-01 0.013 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.695449e-01 0.013 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.695449e-01 0.013 0 0
Dual incision in TC-NER R-HSA-6782135 9.700510e-01 0.013 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.710302e-01 0.013 0 0
Peroxisomal protein import R-HSA-9033241 9.723559e-01 0.012 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.723559e-01 0.012 0 0
Telomere Extension By Telomerase R-HSA-171319 9.726056e-01 0.012 0 0
Pyrimidine salvage R-HSA-73614 9.726056e-01 0.012 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.726056e-01 0.012 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.726056e-01 0.012 0 0
Signaling by FGFR in disease R-HSA-1226099 9.734553e-01 0.012 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.735122e-01 0.012 0 0
PPARA activates gene expression R-HSA-1989781 9.742309e-01 0.011 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.742404e-01 0.011 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.744919e-01 0.011 0 0
Metabolism of polyamines R-HSA-351202 9.744919e-01 0.011 0 0
mRNA Capping R-HSA-72086 9.753588e-01 0.011 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.753588e-01 0.011 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.757881e-01 0.011 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.762275e-01 0.010 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.764706e-01 0.010 0 0
Formation of the cornified envelope R-HSA-6809371 9.776145e-01 0.010 0 0
DAP12 signaling R-HSA-2424491 9.778355e-01 0.010 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.778355e-01 0.010 0 0
Neurotransmitter clearance R-HSA-112311 9.778355e-01 0.010 0 0
Mitochondrial protein import R-HSA-1268020 9.783026e-01 0.010 0 0
G alpha (q) signalling events R-HSA-416476 9.791389e-01 0.009 0 0
Synthesis of PC R-HSA-1483191 9.797858e-01 0.009 0 0
Gluconeogenesis R-HSA-70263 9.815368e-01 0.008 0 0
Insulin receptor signalling cascade R-HSA-74751 9.815669e-01 0.008 0 0
IGF1R signaling cascade R-HSA-2428924 9.815669e-01 0.008 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.827507e-01 0.008 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.830176e-01 0.007 0 0
Disease R-HSA-1643685 9.833818e-01 0.007 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.838702e-01 0.007 0 0
Recycling of bile acids and salts R-HSA-159418 9.838702e-01 0.007 0 0
PI3K Cascade R-HSA-109704 9.846079e-01 0.007 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.846079e-01 0.007 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.854918e-01 0.006 0 0
Heme degradation R-HSA-189483 9.854918e-01 0.006 0 0
Complex IV assembly R-HSA-9864848 9.859510e-01 0.006 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.869505e-01 0.006 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.869505e-01 0.006 0 0
Mitophagy R-HSA-5205647 9.869505e-01 0.006 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.869505e-01 0.006 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.871797e-01 0.006 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.882626e-01 0.005 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.882626e-01 0.005 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.882626e-01 0.005 0 0
Nucleotide biosynthesis R-HSA-8956320 9.883035e-01 0.005 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.894428e-01 0.005 0 0
Metabolism of cofactors R-HSA-8978934 9.896756e-01 0.005 0 0
G alpha (i) signalling events R-HSA-418594 9.901587e-01 0.004 0 0
Paracetamol ADME R-HSA-9753281 9.902702e-01 0.004 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.905044e-01 0.004 0 0
Metabolism of folate and pterines R-HSA-196757 9.905044e-01 0.004 0 0
Neddylation R-HSA-8951664 9.905364e-01 0.004 0 0
Metabolism of proteins R-HSA-392499 9.909226e-01 0.004 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.911284e-01 0.004 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.912721e-01 0.004 0 0
Purine salvage R-HSA-74217 9.914593e-01 0.004 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.914593e-01 0.004 0 0
Gastrulation R-HSA-9758941 9.915926e-01 0.004 0 0
IRS-mediated signalling R-HSA-112399 9.919126e-01 0.004 0 0
RAS processing R-HSA-9648002 9.923183e-01 0.003 0 0
Post-translational protein modification R-HSA-597592 9.926064e-01 0.003 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.926287e-01 0.003 0 0
Tryptophan catabolism R-HSA-71240 9.930909e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.930957e-01 0.003 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.931246e-01 0.003 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.936336e-01 0.003 0 0
Maturation of spike protein R-HSA-9694548 9.937858e-01 0.003 0 0
Cholesterol biosynthesis R-HSA-191273 9.942889e-01 0.002 0 0
Intra-Golgi traffic R-HSA-6811438 9.944109e-01 0.002 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.944109e-01 0.002 0 0
Heme biosynthesis R-HSA-189451 9.944109e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9683701 9.944109e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.944247e-01 0.002 0 0
tRNA processing R-HSA-72306 9.951231e-01 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.951238e-01 0.002 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.951510e-01 0.002 0 0
Pyrimidine catabolism R-HSA-73621 9.954788e-01 0.002 0 0
DAP12 interactions R-HSA-2172127 9.959337e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.963428e-01 0.002 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.967108e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.967108e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.973394e-01 0.001 0 0
Metal ion SLC transporters R-HSA-425410 9.973394e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.976072e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.976072e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.976086e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.977054e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.977207e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.978249e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.978249e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.978249e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.978480e-01 0.001 0 0
Purine catabolism R-HSA-74259 9.980218e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.980646e-01 0.001 0 0
Developmental Cell Lineages R-HSA-9734767 9.980974e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.982012e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.985489e-01 0.001 0 0
Glucuronidation R-HSA-156588 9.985922e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.988106e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.988923e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.989398e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.989760e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.989791e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.990000e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.991111e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.991628e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.991718e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.992980e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.993036e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.993302e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.993302e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.993727e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.994822e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.995129e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.995129e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.995737e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.996201e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.996458e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.996458e-01 0.000 0 0
Kidney development R-HSA-9830369 9.996458e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.997424e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.997684e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.998041e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998538e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998591e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998760e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.998762e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998798e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998809e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.998899e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999010e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999264e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999289e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999409e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999527e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999577e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999631e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999768e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999819e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999821e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999838e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999854e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999925e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999935e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999938e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999949e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999955e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999957e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999959e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999961e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999963e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999968e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999970e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999972e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999986e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999986e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999988e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999989e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999994e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999998e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999998e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999998e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways