SLK

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	T949	Sugiyama	POTEF A26C1B	TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
O43707	T443	Sugiyama	ACTN4	sIHEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDL
O43707	T445	Sugiyama	ACTN4	HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O75534	T761	Sugiyama	CSDE1 D1S155E KIAA0885 NRU UNR	GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN
O75821	T240	Sugiyama	EIF3G EIF3S4	DGAsRRGESMQPNRRADDNAtIRVtNLSEDTRETDLQELFR
O95373	T968	Sugiyama	IPO7 RANBP7	IIDDEDNPVDEYQIFKAIFQtIQNRNPVWyQALTHGLNEEQ
O95678	S162	Sugiyama	KRT75 K6HF KB18	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00441	S103	Sugiyama	SOD1	GDLGNVtADKDGVADVsIEDsVIsLsGDHCIIGRTLVVHEK
P00441	S106	Sugiyama	SOD1	GNVtADKDGVADVsIEDsVIsLsGDHCIIGRTLVVHEKADD
P00441	S99	Sugiyama	SOD1	ERHVGDLGNVtADKDGVADVsIEDsVIsLsGDHCIIGRTLV
P00558	S390	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	IIGGGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPG
P00558	S399	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558	T168	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P02538	S176	Sugiyama	KRT6A K6A KRT6D	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04259	S176	Sugiyama	KRT6B K6B KRTL1	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04406	T246	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05455	S325	Sugiyama	SSB	VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05787	S104	Sugiyama	KRT8 CYK8	IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205	S390	Sugiyama	PGK2 PGKB	VIGGGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPG
P07205	S399	Sugiyama	PGK2 PGKB	CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205	T168	Sugiyama	PGK2 PGKB	EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07900	S476	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	RKKLsELLRyytsAsGDEMVsLKDYCTRMKENQKHIyyItG
P07900	S63	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900	T88	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	sKLDsGKELHINLIPNKQDRtLtIVDtGIGMTKADLINNLG
P07900	T90	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LDsGKELHINLIPNKQDRtLtIVDtGIGMTKADLINNLGtI
P07900	Y465	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IKLGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMK
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	S58	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238	T637	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MGyMMAKKHLEINPDHPIVEtLRQKAEADKNDKAVKDLVVL
P08729	S104	Sugiyama	KRT7 SCL	LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7	S54	Sugiyama	TUBA3C TUBA2	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P0DPH7	T334	Sugiyama	TUBA3C TUBA2	ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
P0DPH7	T41	Sugiyama	TUBA3C TUBA2	WELYCLEHGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKH
P0DPH7	T51	Sugiyama	TUBA3C TUBA2	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P10809	T117	Sugiyama	HSPD1 HSP60	LVQDVANNtNEEAGDGtttAtVLARSIAKEGFEKISKGANP
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11940	T191	Sugiyama	PABPC1 PAB1 PABP PABP1 PABPC2	GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P12035	S211	Sugiyama	KRT3	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13647	S181	Sugiyama	KRT5	IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P14314	T469	Sugiyama	PRKCSH G19P1	WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618	T50	Sugiyama	PKM OIP3 PK2 PK3 PKM2	MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P15311	T567	PSP	EZR VIL2	RTHNDIIHNENMRQGRDKYKtLRQIRQGNTKQRIDEFEAL_
P18615	S135	Sugiyama	NELFE RD RDBP	sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P23246	S283	Sugiyama	SFPQ PSF	GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23526	S183	Sugiyama	AHCY SAHH	NLyKMMANGILKVPAINVNDsVtKsKFDNLyGCRESLIDGI
P23528	T63	Sugiyama	CFL1 CFL	DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528	T70	Sugiyama	CFL1 CFL	EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P25786	T11	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	__________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26038	T558	PSP	MSN	KTANDMIHAENMRLGRDKYKtLRQIRQGNTKQRIDEFEsM_
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26641	T287	Sugiyama	EEF1G EF1G PRO1608	EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P35241	T564	PSP	RDX	KTQNDVLHAENVKAGRDKYKtLRQIRQGNtKQRIDEFEAM_
P35269	T41	Sugiyama	GTF2F1 RAP74	NTTKKyNIMAFNAADKVNFAtWNQARLERDLSNKKIyQEEE
P35908	S191	Sugiyama	KRT2 KRT2A KRT2E	IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37108	T45	Sugiyama	SRP14	sVyItLKKYDGRTKPIPKKGtVEGFEPADNKCLLRATDGKK
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646	T120	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646	T398	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39019	T36	Sugiyama	RPS19	RALAAFLKKSGKLKVPEWVDtVKLAKHKELAPyDENWFytR
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P48668	S176	Sugiyama	KRT6C KRT6E	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	S60	Sugiyama	ACTB	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709	T249	Sugiyama	ACTB	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709	T304	Sugiyama	ACTB	KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P60709	T318	Sugiyama	ACTB	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709	Y294	Sugiyama	ACTB	IHETTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQ
P60709	Y53	Sugiyama	ACTB	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62273	S9	Sugiyama	RPS29	____________MGHQQLyWsHPRKFGQGSRSCRVCSNRHG
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62701	T247	Sugiyama	RPS4X CCG2 RPS4 SCAR	VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	S62	Sugiyama	ACTA2 ACTSA ACTVS GIG46	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736	T251	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736	T320	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736	Y55	Sugiyama	ACTA2 ACTSA ACTVS GIG46	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62826	T66	Sugiyama	RAN ARA24 OK/SW-cl.81	EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62899	T26	Sugiyama	RPL31	KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62917	S138	Sugiyama	RPL8	EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917	T135	Sugiyama	RPL8	CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917	T146	Sugiyama	RPL8	LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63173	T14	Sugiyama	RPL38	_______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	S60	Sugiyama	ACTG1 ACTG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261	T249	Sugiyama	ACTG1 ACTG	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261	T304	Sugiyama	ACTG1 ACTG	KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P63261	T318	Sugiyama	ACTG1 ACTG	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261	Y294	Sugiyama	ACTG1 ACTG	IHETTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQ
P63261	Y53	Sugiyama	ACTG1 ACTG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	S61	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267	T250	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267	T319	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267	Y54	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	S62	Sugiyama	ACTC1 ACTC	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032	T251	Sugiyama	ACTC1 ACTC	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032	T320	Sugiyama	ACTC1 ACTC	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032	Y55	Sugiyama	ACTC1 ACTC	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	S62	Sugiyama	ACTA1 ACTA	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133	T251	Sugiyama	ACTA1 ACTA	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133	T320	Sugiyama	ACTA1 ACTA	VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	Y55	Sugiyama	ACTA1 ACTA	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363	S439	Sugiyama	TUBA1B	SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363	S54	Sugiyama	TUBA1B	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P68363	T334	Sugiyama	TUBA1B	ACCLLyRGDVVPKDVNAAIAtIKtKRsIQFVDWCPTGFKVG
P68363	T41	Sugiyama	TUBA1B	WELYCLEHGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKH
P68363	T51	Sugiyama	TUBA1B	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q01518	T165	Sugiyama	CAP1 CAP	AMAPKPGPYVKEMNDAAMFytNRVLKEYKDVDKKHVDWVKA
Q01546	S196	Sugiyama	KRT76 KRT2B KRT2P	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q07020	T85	Sugiyama	RPL18	RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q13310	T191	Sugiyama	PABPC4 APP1 PABP4	GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q14CN4	S138	Sugiyama	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15293	T71	Sugiyama	RCN1 RCN	EDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRI
Q16658	T239	Sugiyama	FSCN1 FAN1 HSN SNL	GKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALEQs
Q16775	T292	Sugiyama	HAGH GLO2 HAGH1	FMRVREKTVQQHAGETDPVttMRAVRREKDQFKMPRD____
Q3SY84	S143	Sugiyama	KRT71 K6IRS1 KB34 KRT6IRS1	IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q562R1	T250	Sugiyama	ACTBL2	RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q58FF6	S34	Sugiyama	HSP90AB4P	IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7	S58	Sugiyama	HSP90AB3P HSP90BC	IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8	S58	Sugiyama	HSP90AB2P HSP90BB	IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FG1	T28	Sugiyama	HSP90AA4P HSP90AD HSPCAL2	SKLDSGKEPHISLIPNKQDRtLtIVDtGIGMTKADLINNLG
Q58FG1	T30	Sugiyama	HSP90AA4P HSP90AD HSPCAL2	LDSGKEPHISLIPNKQDRtLtIVDtGIGMTKADLINNLGTI
Q5T1R4	S1680	Sugiyama	HIVEP3 KBP1 KIAA1555 KRC ZAS3	ETYTMATAPHPEAGRLVPsSsRKPRMTEVHLPSLVSPEGQK
Q5XKE5	S155	Sugiyama	KRT79 K6L KB38 KRT6L	IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2	S54	Sugiyama	TUBA3E	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q6PEY2	T334	Sugiyama	TUBA3E	ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q6PEY2	T41	Sugiyama	TUBA3E	WELYCLEHGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKH
Q6PEY2	T51	Sugiyama	TUBA3E	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6S8J3	T949	Sugiyama	POTEE A26C1A POTE2	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q71U36	S439	Sugiyama	TUBA1A TUBA3	SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36	S54	Sugiyama	TUBA1A TUBA3	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q71U36	T334	Sugiyama	TUBA1A TUBA3	ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q71U36	T41	Sugiyama	TUBA1A TUBA3	WELYCLEHGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKH
Q71U36	T51	Sugiyama	TUBA1A TUBA3	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q7RTS7	S153	Sugiyama	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z794	S177	Sugiyama	KRT77 KRT1B	IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86Y46	S145	Sugiyama	KRT73 K6IRS3 KB36 KRT6IRS3	IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TD47	T247	Sugiyama	RPS4Y2 RPS4Y2P	VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q92688	T105	Sugiyama	ANP32B APRIL PHAPI2	EKLPNLTHLNLsGNKLKDIstLEPLKKLECLKsLDLFNCEV
Q99426	T120	Sugiyama	TBCB CG22 CKAP1	DVSRVEKytIsQEAyDQRQDtVRSFLKRsKLGRyNEEERAQ
Q99613	T880	Sugiyama	EIF3C EIF3S8	AEKLGsLVENNERVFDHKQGtyGGyFRDQKDGYRKNEGYMR
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3	S54	Sugiyama	TUBA1C TUBA6	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q9BQE3	T334	Sugiyama	TUBA1C TUBA6	ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q9BQE3	T41	Sugiyama	TUBA1C TUBA6	WELYCLEHGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKH
Q9BQE3	T51	Sugiyama	TUBA1C TUBA6	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BYX7	T249	Sugiyama	POTEKP ACTBL3 FKSG30	MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9H2G2	S189	PSP	SLK KIAA0204 STK2	IKLADFGVsAKNTRtIQRRDsFIGtPYWMAPEVVMCETSKD
Q9H2G2	S340	Sugiyama	SLK KIAA0204 STK2	EEDEEEEtENsLPIPAsKRAssDLsIAssEEDKLsQNACIL
Q9H2G2	S341	Sugiyama	SLK KIAA0204 STK2	EDEEEEtENsLPIPAsKRAssDLsIAssEEDKLsQNACILE
Q9H2G2	S344	Sugiyama	SLK KIAA0204 STK2	EEEtENsLPIPAsKRAssDLsIAssEEDKLsQNACILEsVS
Q9H2G2	S347	Sugiyama	SLK KIAA0204 STK2	tENsLPIPAsKRAssDLsIAssEEDKLsQNACILEsVSEKt
Q9H2G2	S362	Sugiyama	SLK KIAA0204 STK2	DLsIAssEEDKLsQNACILEsVSEKtERSNsEDKLNSKILN
Q9H2G2	S446	Sugiyama	SLK KIAA0204 STK2	KRPKLENLPDTEDQEtVDINsVsEGKENNIMITLETNIEHN
Q9H2G2	S448	Sugiyama	SLK KIAA0204 STK2	PKLENLPDTEDQEtVDINsVsEGKENNIMITLETNIEHNLK
Q9H2G2	S518	Sugiyama	SLK KIAA0204 STK2	tVDLVSQEtGEKEANIQAVDsEVGLTKEDtQEKLGEDDKTQ
Q9H2G2	S546	Sugiyama	SLK KIAA0204 STK2	DtQEKLGEDDKTQKDVIsNtsDVIGtCEAADVAQKVDEDsA
Q9H2G2	S565	Sugiyama	SLK KIAA0204 STK2	tsDVIGtCEAADVAQKVDEDsAEDtQsNDGKEVVEVGQKLI
Q9H2G2	S571	Sugiyama	SLK KIAA0204 STK2	tCEAADVAQKVDEDsAEDtQsNDGKEVVEVGQKLINKPMVG
Q9H2G2	S818	Sugiyama	SLK KIAA0204 STK2	FIVDGVEVSVTtSKIVtDsDsKtEELRFLRRQELRELRFLQ
Q9H2G2	T183	PSP	SLK KIAA0204 STK2	FTLDGDIKLADFGVsAKNTRtIQRRDsFIGtPYWMAPEVVM
Q9H2G2	T441	Sugiyama	SLK KIAA0204 STK2	ENEREKRPKLENLPDTEDQEtVDINsVsEGKENNIMITLET
Q9H2G2	T527	Sugiyama	SLK KIAA0204 STK2	GEKEANIQAVDsEVGLTKEDtQEKLGEDDKTQKDVIsNtsD
Q9H2G2	T676	Sugiyama	SLK KIAA0204 STK2	VVADTDQKALGsEVQDASKVtTQIDKEKKEIPVSIKKEPEV
Q9H2G2	T734	Sugiyama	SLK KIAA0204 STK2	NINSDSGENKEEIGSLSKTEtILPPESENPKENDNDSGTGS
Q9H2G2	T809	Sugiyama	SLK KIAA0204 STK2	KKTLKKTRKFIVDGVEVSVTtSKIVtDsDsKtEELRFLRRQ
Q9H2G2	T814	Sugiyama	SLK KIAA0204 STK2	KTRKFIVDGVEVSVTtSKIVtDsDsKtEELRFLRRQELREL
Q9H2G2	T820	Sugiyama	SLK KIAA0204 STK2	VDGVEVSVTtSKIVtDsDsKtEELRFLRRQELRELRFLQKE
Q9H2K8	T181	iPTMNet	TAOK3 DPK JIK KDS MAP3K18	VKLADFGsAsMAsPANsFVGtPyWMAPEVILAMDEGQYDGK
Q9H2K8	Y183	iPTMNet	TAOK3 DPK JIK KDS MAP3K18	LADFGsAsMAsPANsFVGtPyWMAPEVILAMDEGQYDGKVD
Q9NSB2	S178	Sugiyama	KRT84 KRTHB4	AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9UBR2	S78	Sugiyama	CTSZ	SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST
Q9Y597	T673	Sugiyama	KCTD3	sPLLARARRtEsFHSYRDFQtINLNRNVERAVPENGNLGPI

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path
Signal Transduction	R-HSA-162582	2.764357e-07	6.558	1
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.826849e-05	4.738	0
Signaling by ERBB2	R-HSA-1227986	3.064348e-05	4.514	0
RAB geranylgeranylation	R-HSA-8873719	3.064348e-05	4.514	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	5.508803e-05	4.259	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	6.987144e-05	4.156	0
Apoptotic execution phase	R-HSA-75153	7.064857e-05	4.151	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	8.465082e-05	4.072	0
Axon guidance	R-HSA-422475	9.920847e-05	4.003	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.057727e-04	3.976	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.715562e-04	3.766	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.134674e-04	3.671	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.134674e-04	3.671	0
Downregulation of ERBB4 signaling	R-HSA-1253288	2.035550e-04	3.691	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.946189e-04	3.711	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.432226e-04	3.614	0
Signaling by EGFR	R-HSA-177929	3.010408e-04	3.521	0
G alpha (12/13) signalling events	R-HSA-416482	3.024528e-04	3.519	0
NRAGE signals death through JNK	R-HSA-193648	3.010408e-04	3.521	0
Nervous system development	R-HSA-9675108	4.071813e-04	3.390	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	4.612031e-04	3.336	0
Signaling by VEGF	R-HSA-194138	4.880893e-04	3.312	0
Amplification of signal from the kinetochores	R-HSA-141424	6.855757e-04	3.164	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	6.855757e-04	3.164	0
Signaling by Hippo	R-HSA-2028269	7.161970e-04	3.145	0
Intracellular signaling by second messengers	R-HSA-9006925	7.116046e-04	3.148	0
PIP3 activates AKT signaling	R-HSA-1257604	6.728425e-04	3.172	0
Signaling by AMER1 mutants	R-HSA-4839748	8.226316e-04	3.085	0
Signaling by GSK3beta mutants	R-HSA-5339716	8.226316e-04	3.085	0
Sema4D in semaphorin signaling	R-HSA-400685	7.950034e-04	3.100	0
Interleukin-12 signaling	R-HSA-9020591	8.253507e-04	3.083	0
RAF activation	R-HSA-5673000	8.795468e-04	3.056	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.093094e-03	2.961	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.093094e-03	2.961	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.093094e-03	2.961	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.093094e-03	2.961	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.093094e-03	2.961	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	9.889500e-04	3.005	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.136632e-03	2.944	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.156091e-03	2.937	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.207770e-03	2.918	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.370374e-03	2.863	0
EPH-Ephrin signaling	R-HSA-2682334	1.415107e-03	2.849	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.583940e-03	2.800	0
Cell Cycle	R-HSA-1640170	1.564032e-03	2.806	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	1.824313e-03	2.739	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.802833e-03	2.744	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.853621e-03	2.732	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.003202e-03	2.698	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.927175e-03	2.715	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.977067e-03	2.704	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.093815e-03	2.679	0
Beta-catenin phosphorylation cascade	R-HSA-196299	2.300785e-03	2.638	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.300785e-03	2.638	0
Cell Cycle, Mitotic	R-HSA-69278	2.193463e-03	2.659	0
Semaphorin interactions	R-HSA-373755	2.404243e-03	2.619	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.404367e-03	2.619	0
Interleukin-12 family signaling	R-HSA-447115	2.479514e-03	2.606	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.861873e-03	2.543	0
Integrin signaling	R-HSA-354192	2.879808e-03	2.541	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.861873e-03	2.543	0
Mitotic Spindle Checkpoint	R-HSA-69618	2.910434e-03	2.536	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.363319e-03	2.473	0
TRAF6 mediated NF-kB activation	R-HSA-933542	3.363319e-03	2.473	0
Sensory processing of sound	R-HSA-9659379	3.382552e-03	2.471	0
MAPK family signaling cascades	R-HSA-5683057	3.233398e-03	2.490	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	3.515689e-03	2.454	0
Regulation of CDH11 function	R-HSA-9762292	3.629836e-03	2.440	0
PI3K events in ERBB2 signaling	R-HSA-1963642	4.270342e-03	2.370	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.705944e-03	2.327	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.705944e-03	2.327	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.705944e-03	2.327	0
Signaling by APC mutants	R-HSA-4839744	4.705944e-03	2.327	0
Ephrin signaling	R-HSA-3928664	5.133876e-03	2.290	0
Regulation of TP53 Degradation	R-HSA-6804757	4.864857e-03	2.313	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	5.144460e-03	2.289	0
Signaling by ALK in cancer	R-HSA-9700206	5.144460e-03	2.289	0
RET signaling	R-HSA-8853659	4.864857e-03	2.313	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	5.872823e-03	2.231	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	5.876596e-03	2.231	0
Signaling by AXIN mutants	R-HSA-4839735	5.977899e-03	2.223	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	6.781646e-03	2.169	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	6.634505e-03	2.178	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	6.781646e-03	2.169	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	6.781646e-03	2.169	0
Mitotic Prometaphase	R-HSA-68877	6.946032e-03	2.158	0
Platelet calcium homeostasis	R-HSA-418360	6.977924e-03	2.156	0
p75 NTR receptor-mediated signalling	R-HSA-193704	7.089520e-03	2.149	0
Signaling by LTK	R-HSA-9842663	7.460027e-03	2.127	0
Downregulation of ERBB2 signaling	R-HSA-8863795	7.947716e-03	2.100	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	7.510308e-03	2.124	0
Signaling by PTK6	R-HSA-8848021	7.510308e-03	2.124	0
Platelet activation, signaling and aggregation	R-HSA-76002	8.004566e-03	2.097	0
Cell Cycle Checkpoints	R-HSA-69620	8.019312e-03	2.096	0
mRNA 3'-end processing	R-HSA-72187	8.591308e-03	2.066	0
Death Receptor Signaling	R-HSA-73887	9.089412e-03	2.041	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	9.165611e-03	2.038	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	9.327628e-03	2.030	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	9.676753e-03	2.014	0
Signaling by WNT in cancer	R-HSA-4791275	1.017191e-02	1.993	0
MAPK1/MAPK3 signaling	R-HSA-5684996	9.923101e-03	2.003	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	9.832717e-03	2.007	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.050326e-02	1.979	0
Rab regulation of trafficking	R-HSA-9007101	1.087204e-02	1.964	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.143545e-02	1.942	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.199852e-02	1.921	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.218201e-02	1.914	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.218201e-02	1.914	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.226710e-02	1.911	0
Programmed Cell Death	R-HSA-5357801	1.237440e-02	1.907	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.280587e-02	1.893	0
Netrin-1 signaling	R-HSA-373752	1.288767e-02	1.890	0
Neutrophil degranulation	R-HSA-6798695	1.358519e-02	1.867	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.415721e-02	1.849	0
Nuclear import of Rev protein	R-HSA-180746	1.428744e-02	1.845	0
Mitophagy	R-HSA-5205647	1.428744e-02	1.845	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.334308e-02	1.875	0
RAF/MAP kinase cascade	R-HSA-5673001	1.387128e-02	1.858	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.437164e-02	1.842	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.437164e-02	1.842	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.303179e-02	1.885	0
Apoptosis	R-HSA-109581	1.342826e-02	1.872	0
mRNA Splicing - Major Pathway	R-HSA-72163	1.452993e-02	1.838	0
Signaling downstream of RAS mutants	R-HSA-9649948	1.551368e-02	1.809	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.551368e-02	1.809	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.551368e-02	1.809	0
Signaling by RAS mutants	R-HSA-6802949	1.551368e-02	1.809	0
Cellular Senescence	R-HSA-2559583	1.567233e-02	1.805	0
Regulation of TP53 Expression	R-HSA-6804754	1.575126e-02	1.803	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.588431e-02	1.799	0
Oncogene Induced Senescence	R-HSA-2559585	1.588431e-02	1.799	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	1.844808e-02	1.734	0
Co-stimulation by CD28	R-HSA-389356	1.849896e-02	1.733	0
Regulation of PTEN gene transcription	R-HSA-8943724	1.698419e-02	1.770	0
Long-term potentiation	R-HSA-9620244	1.686839e-02	1.773	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.834294e-02	1.737	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.844808e-02	1.734	0
TRP channels	R-HSA-3295583	1.904038e-02	1.720	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.943967e-02	1.711	0
Platelet degranulation	R-HSA-114608	1.964123e-02	1.707	0
WNT mediated activation of DVL	R-HSA-201688	1.994123e-02	1.700	0
EPHA-mediated growth cone collapse	R-HSA-3928663	2.138845e-02	1.670	0
mRNA Splicing	R-HSA-72172	2.259347e-02	1.646	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.386329e-02	1.622	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.468967e-02	1.607	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.350162e-02	1.629	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.573099e-02	1.590	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.455912e-02	1.610	0
AURKA Activation by TPX2	R-HSA-8854518	2.631832e-02	1.580	0
Receptor Mediated Mitophagy	R-HSA-8934903	2.450024e-02	1.611	0
Interactions of Rev with host cellular proteins	R-HSA-177243	2.573099e-02	1.590	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.450024e-02	1.611	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	2.573099e-02	1.590	0
Diseases of Immune System	R-HSA-5260271	2.573099e-02	1.590	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.350162e-02	1.629	0
Signaling by ALK	R-HSA-201556	2.350162e-02	1.629	0
Signaling by Interleukins	R-HSA-449147	2.547486e-02	1.594	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.663111e-02	1.575	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.748666e-02	1.561	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.809669e-02	1.551	0
Mitotic Prophase	R-HSA-68875	2.810842e-02	1.551	0
Rap1 signalling	R-HSA-392517	2.823311e-02	1.549	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.839808e-02	1.547	0
TNFR1-mediated ceramide production	R-HSA-5626978	3.332289e-02	1.477	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	3.332289e-02	1.477	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	3.332289e-02	1.477	0
Defective LFNG causes SCDO3	R-HSA-5083630	3.332289e-02	1.477	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.957302e-02	1.529	0
Co-inhibition by CTLA4	R-HSA-389513	3.206369e-02	1.494	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.953366e-02	1.530	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	3.262822e-02	1.486	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	3.262822e-02	1.486	0
Signaling by RAF1 mutants	R-HSA-9656223	3.060151e-02	1.514	0
EGFR downregulation	R-HSA-182971	3.262822e-02	1.486	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.318809e-02	1.479	0
MAP2K and MAPK activation	R-HSA-5674135	3.060151e-02	1.514	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	3.332289e-02	1.477	0
M Phase	R-HSA-68886	3.030222e-02	1.519	0
Negative regulation of MAPK pathway	R-HSA-5675221	3.060151e-02	1.514	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.909309e-02	1.536	0
Nephrin family interactions	R-HSA-373753	3.206369e-02	1.494	0
Ion homeostasis	R-HSA-5578775	3.445460e-02	1.463	0
Oncogenic MAPK signaling	R-HSA-6802957	3.514638e-02	1.454	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	3.515572e-02	1.454	0
Activation of RAC1	R-HSA-428540	3.515572e-02	1.454	0
G0 and Early G1	R-HSA-1538133	3.591758e-02	1.445	0
Signaling by FGFR4	R-HSA-5654743	3.603839e-02	1.443	0
TBC/RABGAPs	R-HSA-8854214	3.603839e-02	1.443	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	3.618404e-02	1.441	0
SHC-related events triggered by IGF1R	R-HSA-2428933	4.124131e-02	1.385	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	4.059565e-02	1.392	0
IPs transport between nucleus and cytosol	R-HSA-1855170	3.940409e-02	1.404	0
Striated Muscle Contraction	R-HSA-390522	4.308956e-02	1.366	0
snRNP Assembly	R-HSA-191859	4.225264e-02	1.374	0
Metabolism of non-coding RNA	R-HSA-194441	4.225264e-02	1.374	0
Signaling by ERBB4	R-HSA-1236394	4.361646e-02	1.360	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.940409e-02	1.404	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	4.398868e-02	1.357	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	4.124131e-02	1.385	0
Mitotic G2-G2/M phases	R-HSA-453274	4.055003e-02	1.392	0
G2/M Transition	R-HSA-69275	3.773490e-02	1.423	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	4.066528e-02	1.391	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.059565e-02	1.392	0
Signaling by FGFR3	R-HSA-5654741	4.205906e-02	1.376	0
Ub-specific processing proteases	R-HSA-5689880	4.290604e-02	1.367	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	4.059565e-02	1.392	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.940409e-02	1.404	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	4.308956e-02	1.366	0
Deubiquitination	R-HSA-5688426	4.116764e-02	1.385	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.940409e-02	1.404	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.711519e-02	1.430	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.711519e-02	1.430	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.711519e-02	1.430	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.398868e-02	1.357	0
Hemostasis	R-HSA-109582	4.499566e-02	1.347	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	4.616039e-02	1.336	0
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	4.616039e-02	1.336	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	4.616039e-02	1.336	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	4.616039e-02	1.336	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.782001e-02	1.320	0
Recycling pathway of L1	R-HSA-437239	4.867701e-02	1.313	0
GPER1 signaling	R-HSA-9634597	5.221308e-02	1.282	0
Cell-Cell communication	R-HSA-1500931	5.267109e-02	1.278	0
Muscle contraction	R-HSA-397014	5.329803e-02	1.273	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	5.430576e-02	1.265	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	5.430576e-02	1.265	0
G1/S DNA Damage Checkpoints	R-HSA-69615	5.430576e-02	1.265	0
Phosphorylation of Emi1	R-HSA-176417	5.572947e-02	1.254	0
IkBA variant leads to EDA-ID	R-HSA-5603029	5.572947e-02	1.254	0
Formation of lateral plate mesoderm	R-HSA-9758920	5.572947e-02	1.254	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.572947e-02	1.254	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.572947e-02	1.254	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	5.590169e-02	1.253	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	5.590169e-02	1.253	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.842356e-02	1.165	0
G2/M DNA replication checkpoint	R-HSA-69478	6.842356e-02	1.165	0
Spry regulation of FGF signaling	R-HSA-1295596	6.240588e-02	1.205	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	7.038284e-02	1.153	0
Transcriptional Regulation by E2F6	R-HSA-8953750	6.942518e-02	1.158	0
Myogenesis	R-HSA-525793	6.700318e-02	1.174	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	7.038284e-02	1.153	0
Killing mechanisms	R-HSA-9664420	7.038284e-02	1.153	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	7.038284e-02	1.153	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	6.700318e-02	1.174	0
Parasite infection	R-HSA-9664407	7.363425e-02	1.133	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	7.363425e-02	1.133	0
Leishmania phagocytosis	R-HSA-9664417	7.363425e-02	1.133	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.842356e-02	1.165	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	5.984162e-02	1.223	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	7.313758e-02	1.136	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	7.038284e-02	1.153	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	6.218370e-02	1.206	0
Regulated Necrosis	R-HSA-5218859	7.211582e-02	1.142	0
Mitotic Anaphase	R-HSA-68882	6.033044e-02	1.219	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.241663e-02	1.205	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.516004e-02	1.186	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	6.453324e-02	1.190	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	7.313758e-02	1.136	0
Nuclear signaling by ERBB4	R-HSA-1251985	7.451612e-02	1.128	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	7.451612e-02	1.128	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	7.604779e-02	1.119	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.689860e-02	1.114	0
Toll-like Receptor Cascades	R-HSA-168898	7.822311e-02	1.107	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	7.879305e-02	1.104	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	7.879305e-02	1.104	0
Pyroptosis	R-HSA-5620971	7.954667e-02	1.099	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	7.980436e-02	1.098	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	8.195817e-02	1.086	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	8.195817e-02	1.086	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	8.195817e-02	1.086	0
Netrin mediated repulsion signals	R-HSA-418886	8.195817e-02	1.086	0
MECP2 regulates transcription factors	R-HSA-9022707	8.195817e-02	1.086	0
Leishmania infection	R-HSA-9658195	8.407022e-02	1.075	0
Parasitic Infection Pathways	R-HSA-9824443	8.407022e-02	1.075	0
Regulation of TP53 Activity	R-HSA-5633007	8.453396e-02	1.073	0
Glycolysis	R-HSA-70171	8.460246e-02	1.073	0
Signaling by FGFR1	R-HSA-5654736	8.600794e-02	1.065	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	8.622487e-02	1.064	0
Signaling by Erythropoietin	R-HSA-9006335	8.622487e-02	1.064	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	8.651204e-02	1.063	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	8.761787e-02	1.057	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	8.761787e-02	1.057	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	8.761787e-02	1.057	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	8.761787e-02	1.057	0
Post NMDA receptor activation events	R-HSA-438064	8.902874e-02	1.050	0
Diseases of Telomere Maintenance	R-HSA-9673013	9.019266e-02	1.045	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	9.019266e-02	1.045	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	9.019266e-02	1.045	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	9.019266e-02	1.045	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	9.019266e-02	1.045	0
Inhibition of PKR	R-HSA-169131	9.019266e-02	1.045	0
Signaling by MRAS-complex mutants	R-HSA-9660537	9.622888e-02	1.017	0
Activation of RAS in B cells	R-HSA-1169092	9.622888e-02	1.017	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	9.622888e-02	1.017	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	1.111391e-01	0.954	0
GAB1 signalosome	R-HSA-180292	9.683771e-02	1.014	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.078087e-01	0.967	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	9.300455e-02	1.031	0
Centrosome maturation	R-HSA-380287	1.022121e-01	0.990	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.169136e-01	0.932	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.013717e-01	0.994	0
Germ layer formation at gastrulation	R-HSA-9754189	1.064322e-01	0.973	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	1.111391e-01	0.954	0
G1 Phase	R-HSA-69236	1.028827e-01	0.988	0
Cyclin D associated events in G1	R-HSA-69231	1.028827e-01	0.988	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	1.192375e-01	0.924	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.202496e-01	0.920	0
Selective autophagy	R-HSA-9663891	9.304118e-02	1.031	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.111391e-01	0.954	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.091188e-01	0.962	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.056887e-01	0.976	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.221250e-01	0.913	0
Oxidative Stress Induced Senescence	R-HSA-2559580	9.183832e-02	1.037	0
GP1b-IX-V activation signalling	R-HSA-430116	1.111391e-01	0.954	0
Formation of definitive endoderm	R-HSA-9823730	1.163804e-01	0.934	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.111391e-01	0.954	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.073642e-01	0.969	0
Cell junction organization	R-HSA-446728	1.199331e-01	0.921	0
Signaling by NTRKs	R-HSA-166520	9.994084e-02	1.000	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.111391e-01	0.954	0
Separation of Sister Chromatids	R-HSA-2467813	9.593095e-02	1.018	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	9.622888e-02	1.017	0
Interleukin-1 processing	R-HSA-448706	1.111391e-01	0.954	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.155342e-01	0.937	0
Platelet homeostasis	R-HSA-418346	1.114632e-01	0.953	0
ISG15 antiviral mechanism	R-HSA-1169408	1.022121e-01	0.990	0
Platelet sensitization by LDL	R-HSA-432142	9.683771e-02	1.014	0
Stimuli-sensing channels	R-HSA-2672351	1.199183e-01	0.921	0
Interleukin-37 signaling	R-HSA-9008059	9.316592e-02	1.031	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	1.234144e-01	0.909	0
Effects of PIP2 hydrolysis	R-HSA-114508	1.234144e-01	0.909	0
MET activates RAP1 and RAC1	R-HSA-8875555	1.265996e-01	0.898	0
Signal attenuation	R-HSA-74749	1.265996e-01	0.898	0
Formation of intermediate mesoderm	R-HSA-9761174	1.265996e-01	0.898	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.266611e-01	0.897	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.266611e-01	0.897	0
Signalling to RAS	R-HSA-167044	1.266611e-01	0.897	0
Early Phase of HIV Life Cycle	R-HSA-162594	1.266611e-01	0.897	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.280671e-01	0.893	0
Innate Immune System	R-HSA-168249	1.284789e-01	0.891	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.287117e-01	0.890	0
MyD88-independent TLR4 cascade	R-HSA-166166	1.287117e-01	0.890	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.287588e-01	0.890	0
IGF1R signaling cascade	R-HSA-2428924	1.293325e-01	0.888	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	1.321948e-01	0.879	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	1.321948e-01	0.879	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	1.321948e-01	0.879	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	1.321948e-01	0.879	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	1.349999e-01	0.870	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	1.353747e-01	0.868	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.354790e-01	0.868	0
Degradation of CDH1	R-HSA-9766229	1.358152e-01	0.867	0
Mitochondrial calcium ion transport	R-HSA-8949215	1.372525e-01	0.862	0
Signalling to ERKs	R-HSA-187687	1.399151e-01	0.854	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.415475e-01	0.849	0
Activated NTRK3 signals through RAS	R-HSA-9034864	1.425279e-01	0.846	0
RHOBTB3 ATPase cycle	R-HSA-9706019	1.425279e-01	0.846	0
Formation of the posterior neural plate	R-HSA-9832991	1.425279e-01	0.846	0
Interleukin-2 signaling	R-HSA-9020558	1.425279e-01	0.846	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.460586e-01	0.835	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.722603e-01	0.764	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.722603e-01	0.764	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.722603e-01	0.764	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.722603e-01	0.764	0
Potassium transport channels	R-HSA-1296067	1.722603e-01	0.764	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.722603e-01	0.764	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.722603e-01	0.764	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.722603e-01	0.764	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	1.722603e-01	0.764	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.722603e-01	0.764	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	1.722603e-01	0.764	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.722603e-01	0.764	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.722603e-01	0.764	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.722603e-01	0.764	0
MET activates PTPN11	R-HSA-8865999	2.104784e-01	0.677	0
Classical Kir channels	R-HSA-1296053	2.104784e-01	0.677	0
ATP sensitive Potassium channels	R-HSA-1296025	2.469341e-01	0.607	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	2.469341e-01	0.607	0
Nucleotide catabolism defects	R-HSA-9735786	2.469341e-01	0.607	0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	2.469341e-01	0.607	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.469341e-01	0.607	0
IRS activation	R-HSA-74713	2.817085e-01	0.550	0
G2 Phase	R-HSA-68911	2.817085e-01	0.550	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	1.588481e-01	0.799	0
Activated NTRK2 signals through RAS	R-HSA-9026519	1.588481e-01	0.799	0
PI3K events in ERBB4 signaling	R-HSA-1250342	1.588481e-01	0.799	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.754902e-01	0.756	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	3.148792e-01	0.502	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	3.148792e-01	0.502	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	3.148792e-01	0.502	0
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)	R-HSA-5619063	3.148792e-01	0.502	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.923898e-01	0.716	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.923898e-01	0.716	0
Signaling by LTK in cancer	R-HSA-9842640	3.465200e-01	0.460	0
STAT5 Activation	R-HSA-9645135	3.465200e-01	0.460	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.465200e-01	0.460	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.267299e-01	0.644	0
SHC1 events in EGFR signaling	R-HSA-180336	2.267299e-01	0.644	0
Phase 4 - resting membrane potential	R-HSA-5576886	2.440665e-01	0.612	0
Phosphorylation of the APC/C	R-HSA-176412	2.440665e-01	0.612	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.440665e-01	0.612	0
MET activates PI3K/AKT signaling	R-HSA-8851907	3.767014e-01	0.424	0
RUNX3 regulates WNT signaling	R-HSA-8951430	3.767014e-01	0.424	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.767014e-01	0.424	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.767014e-01	0.424	0
IFNG signaling activates MAPKs	R-HSA-9732724	3.767014e-01	0.424	0
SOS-mediated signalling	R-HSA-112412	3.767014e-01	0.424	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.061205e-01	0.686	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	4.054905e-01	0.392	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	4.054905e-01	0.392	0
MET receptor recycling	R-HSA-8875656	4.054905e-01	0.392	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	4.054905e-01	0.392	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	2.962088e-01	0.528	0
PKA activation in glucagon signalling	R-HSA-164378	2.962088e-01	0.528	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.430310e-01	0.614	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	3.135079e-01	0.504	0
CASP8 activity is inhibited	R-HSA-5218900	4.329516e-01	0.364	0
ALK mutants bind TKIs	R-HSA-9700645	4.329516e-01	0.364	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	3.307116e-01	0.481	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.477920e-01	0.459	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	3.477920e-01	0.459	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	3.477920e-01	0.459	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	3.647238e-01	0.438	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.793026e-01	0.746	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.814843e-01	0.419	0
Interleukin receptor SHC signaling	R-HSA-912526	3.980533e-01	0.400	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	4.144127e-01	0.383	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.264707e-01	0.486	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	3.830353e-01	0.417	0
Signaling by EGFR in Cancer	R-HSA-1643713	1.941157e-01	0.712	0
PKR-mediated signaling	R-HSA-9833482	2.397694e-01	0.620	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.670396e-01	0.777	0
DAP12 signaling	R-HSA-2424491	2.430310e-01	0.614	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	3.477920e-01	0.459	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	3.940085e-01	0.404	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.754902e-01	0.756	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	3.767014e-01	0.424	0
Inwardly rectifying K+ channels	R-HSA-1296065	2.681936e-01	0.572	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.282933e-01	0.484	0
Regulation of T cell activation by CD28 family	R-HSA-388841	2.387215e-01	0.622	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.817085e-01	0.550	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.440665e-01	0.612	0
VxPx cargo-targeting to cilium	R-HSA-5620916	3.307116e-01	0.481	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	3.575998e-01	0.447	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.182877e-01	0.661	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.962088e-01	0.528	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.305977e-01	0.637	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	3.064147e-01	0.514	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	3.064147e-01	0.514	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	2.636759e-01	0.579	0
Adipogenesis	R-HSA-9843745	2.633940e-01	0.579	0
Regulation of gap junction activity	R-HSA-191650	2.469341e-01	0.607	0
Erythropoietin activates RAS	R-HSA-9027284	2.267299e-01	0.644	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	2.182877e-01	0.661	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.962088e-01	0.528	0
PKA activation	R-HSA-163615	2.962088e-01	0.528	0
E2F mediated regulation of DNA replication	R-HSA-113510	3.135079e-01	0.504	0
Transcriptional Regulation by TP53	R-HSA-3700989	2.225918e-01	0.652	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	2.808872e-01	0.551	0
Insulin receptor signalling cascade	R-HSA-74751	4.424074e-01	0.354	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	3.477920e-01	0.459	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	2.456777e-01	0.610	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.386076e-01	0.622	0
Clathrin-mediated endocytosis	R-HSA-8856828	2.353309e-01	0.628	0
TNF signaling	R-HSA-75893	3.582742e-01	0.446	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.817085e-01	0.550	0
Tight junction interactions	R-HSA-420029	1.822937e-01	0.739	0
Calcineurin activates NFAT	R-HSA-2025928	4.329516e-01	0.364	0
MET promotes cell motility	R-HSA-8875878	3.575998e-01	0.447	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	4.082357e-01	0.389	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	4.207208e-01	0.376	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	1.923898e-01	0.716	0
FOXO-mediated transcription	R-HSA-9614085	1.542040e-01	0.812	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.706752e-01	0.768	0
Regulation of TNFR1 signaling	R-HSA-5357905	2.534209e-01	0.596	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	2.817085e-01	0.550	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	3.148792e-01	0.502	0
Lysosphingolipid and LPA receptors	R-HSA-419408	2.267299e-01	0.644	0
p38MAPK events	R-HSA-171007	2.267299e-01	0.644	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	3.767014e-01	0.424	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.941157e-01	0.712	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.329516e-01	0.364	0
GPVI-mediated activation cascade	R-HSA-114604	3.320244e-01	0.479	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	1.845943e-01	0.734	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	1.845943e-01	0.734	0
Regulation of signaling by CBL	R-HSA-912631	3.135079e-01	0.504	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.674829e-01	0.776	0
Regulation of CDH1 Function	R-HSA-9764561	1.966169e-01	0.706	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.329516e-01	0.364	0
Cyclin E associated events during G1/S transition	R-HSA-69202	3.099598e-01	0.509	0
Signaling by SCF-KIT	R-HSA-1433557	2.232095e-01	0.651	0
TRAF6 mediated IRF7 activation	R-HSA-933541	3.448233e-01	0.462	0
Specification of the neural plate border	R-HSA-9834899	3.135079e-01	0.504	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.305977e-01	0.637	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.521553e-01	0.598	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.427786e-01	0.615	0
Response of endothelial cells to shear stress	R-HSA-9860931	1.818450e-01	0.740	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.722603e-01	0.764	0
Dopamine receptors	R-HSA-390651	2.469341e-01	0.607	0
Reelin signalling pathway	R-HSA-8866376	2.817085e-01	0.550	0
Suppression of autophagy	R-HSA-9636569	2.817085e-01	0.550	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	1.588481e-01	0.799	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	3.148792e-01	0.502	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	3.465200e-01	0.460	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.267299e-01	0.644	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	1.822937e-01	0.739	0
Regulation by c-FLIP	R-HSA-3371378	4.054905e-01	0.392	0
Fructose biosynthesis	R-HSA-5652227	4.054905e-01	0.392	0
Co-stimulation by ICOS	R-HSA-9927354	4.054905e-01	0.392	0
Inactivation of CDC42 and RAC1	R-HSA-428543	4.329516e-01	0.364	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.647238e-01	0.438	0
Notch-HLH transcription pathway	R-HSA-350054	3.814843e-01	0.419	0
Signaling by MET	R-HSA-6806834	2.397694e-01	0.620	0
Signaling by FGFR1 in disease	R-HSA-5655302	4.082357e-01	0.389	0
Downstream signaling of activated FGFR3	R-HSA-5654708	2.305977e-01	0.637	0
Downstream signaling of activated FGFR4	R-HSA-5654716	2.430310e-01	0.614	0
Downstream signaling of activated FGFR2	R-HSA-5654696	3.192168e-01	0.496	0
Signaling by FGFR2	R-HSA-5654738	2.397694e-01	0.620	0
Regulation of mitotic cell cycle	R-HSA-453276	1.742609e-01	0.759	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.742609e-01	0.759	0
Polo-like kinase mediated events	R-HSA-156711	2.962088e-01	0.528	0
G-protein beta:gamma signalling	R-HSA-397795	2.808872e-01	0.551	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.375018e-01	0.472	0
Transcriptional Regulation by VENTX	R-HSA-8853884	1.940391e-01	0.712	0
Autophagy	R-HSA-9612973	4.387080e-01	0.358	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	1.706752e-01	0.768	0
Downstream signaling of activated FGFR1	R-HSA-5654687	3.192168e-01	0.496	0
Developmental Cell Lineages	R-HSA-9734767	3.629538e-01	0.440	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.397694e-01	0.620	0
Macroautophagy	R-HSA-1632852	3.331175e-01	0.477	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	2.817085e-01	0.550	0
Acetylcholine regulates insulin secretion	R-HSA-399997	2.614521e-01	0.583	0
Cellular responses to mechanical stimuli	R-HSA-9855142	2.492231e-01	0.603	0
FLT3 signaling in disease	R-HSA-9682385	1.484785e-01	0.828	0
Evasion by RSV of host interferon responses	R-HSA-9833109	2.555690e-01	0.592	0
Negative regulation of MET activity	R-HSA-6807004	3.307116e-01	0.481	0
G2/M DNA damage checkpoint	R-HSA-69473	3.467305e-01	0.460	0
Membrane Trafficking	R-HSA-199991	2.932137e-01	0.533	0
Neurodegenerative Diseases	R-HSA-8863678	1.706752e-01	0.768	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.706752e-01	0.768	0
Gastrulation	R-HSA-9758941	3.923195e-01	0.406	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.469341e-01	0.607	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.767014e-01	0.424	0
Potassium Channels	R-HSA-1296071	3.940085e-01	0.404	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	4.122093e-01	0.385	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.386076e-01	0.622	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	3.064147e-01	0.514	0
Regulation of BACH1 activity	R-HSA-9708530	2.440665e-01	0.612	0
Smooth Muscle Contraction	R-HSA-445355	3.264707e-01	0.486	0
Acyl chain remodelling of PS	R-HSA-1482801	4.305466e-01	0.366	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.320265e-01	0.364	0
Signaling by FGFR	R-HSA-190236	4.106311e-01	0.387	0
Interleukin-15 signaling	R-HSA-8983432	1.754902e-01	0.756	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	1.941157e-01	0.712	0
Diseases of programmed cell death	R-HSA-9645723	1.793026e-01	0.746	0
FLT3 Signaling	R-HSA-9607240	1.940391e-01	0.712	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.133569e-01	0.671	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.817085e-01	0.550	0
Signalling to p38 via RIT and RIN	R-HSA-187706	3.148792e-01	0.502	0
Ca2+ activated K+ channels	R-HSA-1296052	3.767014e-01	0.424	0
Dimerization of procaspase-8	R-HSA-69416	4.054905e-01	0.392	0
ARMS-mediated activation	R-HSA-170984	4.329516e-01	0.364	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.329516e-01	0.364	0
Regulation of necroptotic cell death	R-HSA-5675482	2.808872e-01	0.551	0
Viral Messenger RNA Synthesis	R-HSA-168325	2.300120e-01	0.638	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.370619e-01	0.472	0
Extra-nuclear estrogen signaling	R-HSA-9009391	2.813997e-01	0.551	0
Cardiac conduction	R-HSA-5576891	2.633940e-01	0.579	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.034188e-01	0.518	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	4.022257e-01	0.396	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.030463e-01	0.692	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.030463e-01	0.692	0
PLC beta mediated events	R-HSA-112043	4.111158e-01	0.386	0
G1/S Transition	R-HSA-69206	3.440498e-01	0.463	0
Cellular response to heat stress	R-HSA-3371556	3.093831e-01	0.510	0
Calmodulin induced events	R-HSA-111933	3.320244e-01	0.479	0
Cell-cell junction organization	R-HSA-421270	1.490807e-01	0.827	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	3.148792e-01	0.502	0
Cell-extracellular matrix interactions	R-HSA-446353	2.267299e-01	0.644	0
Adherens junctions interactions	R-HSA-418990	2.408554e-01	0.618	0
Transcriptional regulation by RUNX3	R-HSA-8878159	4.023235e-01	0.395	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.705385e-01	0.768	0
Immune System	R-HSA-168256	2.645505e-01	0.577	0
CaM pathway	R-HSA-111997	3.320244e-01	0.479	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	3.065368e-01	0.514	0
Neuronal System	R-HSA-112316	2.981962e-01	0.525	0
Developmental Biology	R-HSA-1266738	3.057278e-01	0.515	0
Histamine receptors	R-HSA-390650	2.104784e-01	0.677	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.465200e-01	0.460	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.647238e-01	0.438	0
L1CAM interactions	R-HSA-373760	2.755222e-01	0.560	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	3.575998e-01	0.447	0
MAPK6/MAPK4 signaling	R-HSA-5687128	2.789521e-01	0.554	0
Regulation of NF-kappa B signaling	R-HSA-9758274	2.440665e-01	0.612	0
Interleukin-2 family signaling	R-HSA-451927	3.830353e-01	0.417	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.481331e-01	0.829	0
Formation of the anterior neural plate	R-HSA-9823739	2.267299e-01	0.644	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.651071e-01	0.438	0
Ca-dependent events	R-HSA-111996	4.207208e-01	0.376	0
Interleukin-1 signaling	R-HSA-9020702	4.354735e-01	0.361	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	2.469341e-01	0.607	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	2.817085e-01	0.550	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.817085e-01	0.550	0
CLEC7A/inflammasome pathway	R-HSA-5660668	3.148792e-01	0.502	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	3.148792e-01	0.502	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.767014e-01	0.424	0
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)	R-HSA-9026762	3.767014e-01	0.424	0
Cation-coupled Chloride cotransporters	R-HSA-426117	3.767014e-01	0.424	0
Adrenoceptors	R-HSA-390696	4.054905e-01	0.392	0
Downstream signal transduction	R-HSA-186763	2.555690e-01	0.592	0
RUNX2 regulates bone development	R-HSA-8941326	3.320244e-01	0.479	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.980533e-01	0.400	0
TGFBR3 expression	R-HSA-9839394	4.305466e-01	0.366	0
Maturation of spike protein	R-HSA-9694548	3.956704e-01	0.403	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.941157e-01	0.712	0
Cytokine Signaling in Immune system	R-HSA-1280215	2.018463e-01	0.695	0
HDMs demethylate histones	R-HSA-3214842	4.305466e-01	0.366	0
PKMTs methylate histone lysines	R-HSA-3214841	1.940391e-01	0.712	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.754902e-01	0.756	0
HDL assembly	R-HSA-8963896	2.094878e-01	0.679	0
Azathioprine ADME	R-HSA-9748787	2.948583e-01	0.530	0
Ovarian tumor domain proteases	R-HSA-5689896	3.448233e-01	0.462	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.099598e-01	0.509	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	4.082357e-01	0.389	0
Formation of the nephric duct	R-HSA-9830364	1.822937e-01	0.739	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.148792e-01	0.502	0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	3.148792e-01	0.502	0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	3.148792e-01	0.502	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.923898e-01	0.716	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	3.465200e-01	0.460	0
Synthesis of PG	R-HSA-1483148	2.614521e-01	0.583	0
Regulated proteolysis of p75NTR	R-HSA-193692	4.329516e-01	0.364	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	4.329516e-01	0.364	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.099598e-01	0.509	0
Transcriptional regulation by small RNAs	R-HSA-5578749	3.282933e-01	0.484	0
Chromatin modifying enzymes	R-HSA-3247509	4.244476e-01	0.372	0
Transcriptional regulation by RUNX2	R-HSA-8878166	2.957246e-01	0.529	0
Interleukin-1 family signaling	R-HSA-446652	2.869500e-01	0.542	0
Signaling by ROBO receptors	R-HSA-376176	2.560575e-01	0.592	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.267299e-01	0.644	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	2.962088e-01	0.528	0
Signal transduction by L1	R-HSA-445144	3.307116e-01	0.481	0
G1/S-Specific Transcription	R-HSA-69205	1.484785e-01	0.828	0
Apoptotic factor-mediated response	R-HSA-111471	2.962088e-01	0.528	0
PTEN Regulation	R-HSA-6807070	2.082834e-01	0.681	0
Inositol phosphate metabolism	R-HSA-1483249	3.711388e-01	0.430	0
Ribavirin ADME	R-HSA-9755088	3.647238e-01	0.438	0
Potential therapeutics for SARS	R-HSA-9679191	2.751969e-01	0.560	0
STING mediated induction of host immune responses	R-HSA-1834941	3.135079e-01	0.504	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	2.386076e-01	0.622	0
MITF-M-dependent gene expression	R-HSA-9856651	2.751969e-01	0.560	0
Glucose metabolism	R-HSA-70326	1.722688e-01	0.764	0
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	2.817085e-01	0.550	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.148792e-01	0.502	0
ROBO receptors bind AKAP5	R-HSA-9010642	4.054905e-01	0.392	0
Activated NTRK2 signals through FYN	R-HSA-9032500	4.054905e-01	0.392	0
Tie2 Signaling	R-HSA-210993	2.962088e-01	0.528	0
Regulation of CDH11 gene transcription	R-HSA-9762293	4.329516e-01	0.364	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	4.329516e-01	0.364	0
tRNA processing in the nucleus	R-HSA-6784531	2.386076e-01	0.622	0
Syndecan interactions	R-HSA-3000170	3.980533e-01	0.400	0
Specification of primordial germ cells	R-HSA-9827857	2.788455e-01	0.555	0
Plasma lipoprotein assembly	R-HSA-8963898	4.144127e-01	0.383	0
Ion channel transport	R-HSA-983712	3.955265e-01	0.403	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	1.923898e-01	0.716	0
SLC transporter disorders	R-HSA-5619102	3.785466e-01	0.422	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	2.788455e-01	0.555	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.962088e-01	0.528	0
SARS-CoV Infections	R-HSA-9679506	3.905334e-01	0.408	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	2.094878e-01	0.679	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	3.135079e-01	0.504	0
Glutathione conjugation	R-HSA-156590	4.005985e-01	0.397	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	4.424074e-01	0.354	0
The NLRP3 inflammasome	R-HSA-844456	3.135079e-01	0.504	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.437163e-01	0.353	0
HIV Life Cycle	R-HSA-162587	4.453167e-01	0.351	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	4.454128e-01	0.351	0
DAP12 interactions	R-HSA-2172127	4.454128e-01	0.351	0
EPHB-mediated forward signaling	R-HSA-3928662	4.454128e-01	0.351	0
Amine ligand-binding receptors	R-HSA-375280	4.454128e-01	0.351	0
Protein-protein interactions at synapses	R-HSA-6794362	4.480803e-01	0.349	0
Signaling by NOTCH	R-HSA-157118	4.571035e-01	0.340	0
Nucleosome assembly	R-HSA-774815	4.576022e-01	0.340	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.576022e-01	0.340	0
DAG and IP3 signaling	R-HSA-1489509	4.576022e-01	0.340	0
2-LTR circle formation	R-HSA-164843	4.591459e-01	0.338	0
PI3K/AKT activation	R-HSA-198203	4.591459e-01	0.338	0
Binding and entry of HIV virion	R-HSA-173107	4.591459e-01	0.338	0
EGFR Transactivation by Gastrin	R-HSA-2179392	4.591459e-01	0.338	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.591459e-01	0.338	0
CASP4 inflammasome assembly	R-HSA-9948001	4.591459e-01	0.338	0
Pexophagy	R-HSA-9664873	4.591459e-01	0.338	0
Maturation of spike protein	R-HSA-9683686	4.591459e-01	0.338	0
MAPK3 (ERK1) activation	R-HSA-110056	4.591459e-01	0.338	0
Apoptosis induced DNA fragmentation	R-HSA-140342	4.591459e-01	0.338	0
Signaling by Leptin	R-HSA-2586552	4.591459e-01	0.338	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	4.591459e-01	0.338	0
RNA Polymerase I Transcription Termination	R-HSA-73863	4.620835e-01	0.335	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	4.620835e-01	0.335	0
Cristae formation	R-HSA-8949613	4.620835e-01	0.335	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	4.620835e-01	0.335	0
Triglyceride biosynthesis	R-HSA-75109	4.620835e-01	0.335	0
mRNA Splicing - Minor Pathway	R-HSA-72165	4.696764e-01	0.328	0
Condensation of Prophase Chromosomes	R-HSA-2299718	4.696764e-01	0.328	0
G-protein mediated events	R-HSA-112040	4.731832e-01	0.325	0
Host Interactions of HIV factors	R-HSA-162909	4.772345e-01	0.321	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.774635e-01	0.321	0
Inflammasomes	R-HSA-622312	4.774635e-01	0.321	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.786121e-01	0.320	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	4.841316e-01	0.315	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.841316e-01	0.315	0
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	4.841316e-01	0.315	0
Bicarbonate transporters	R-HSA-425381	4.841316e-01	0.315	0
PECAM1 interactions	R-HSA-210990	4.841316e-01	0.315	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.841316e-01	0.315	0
Dissolution of Fibrin Clot	R-HSA-75205	4.841316e-01	0.315	0
SARS-CoV-1-host interactions	R-HSA-9692914	4.845025e-01	0.315	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	4.847340e-01	0.314	0
Gene Silencing by RNA	R-HSA-211000	4.925534e-01	0.308	0
DARPP-32 events	R-HSA-180024	4.925719e-01	0.308	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	4.925719e-01	0.308	0
ER-Phagosome pathway	R-HSA-1236974	4.929853e-01	0.307	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	4.934509e-01	0.307	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	5.005625e-01	0.301	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.032999e-01	0.298	0
Chromatin organization	R-HSA-4839726	5.056372e-01	0.296	0
SARS-CoV-2-host interactions	R-HSA-9705683	5.066944e-01	0.295	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	5.074011e-01	0.295	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	5.079645e-01	0.294	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	5.079645e-01	0.294	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.079645e-01	0.294	0
NF-kB is activated and signals survival	R-HSA-209560	5.079645e-01	0.294	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.079645e-01	0.294	0
ERKs are inactivated	R-HSA-202670	5.079645e-01	0.294	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.079645e-01	0.294	0
Sodium/Calcium exchangers	R-HSA-425561	5.079645e-01	0.294	0
Integration of provirus	R-HSA-162592	5.079645e-01	0.294	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	5.079645e-01	0.294	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	5.131705e-01	0.290	0
PI3K Cascade	R-HSA-109704	5.166842e-01	0.287	0
Gene expression (Transcription)	R-HSA-74160	5.183881e-01	0.285	0
Trafficking of AMPA receptors	R-HSA-399719	5.219444e-01	0.282	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	5.219444e-01	0.282	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	5.229502e-01	0.282	0
Cilium Assembly	R-HSA-5617833	5.273132e-01	0.278	0
HSF1-dependent transactivation	R-HSA-3371571	5.280839e-01	0.277	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.306978e-01	0.275	0
IRAK1 recruits IKK complex	R-HSA-937039	5.306978e-01	0.275	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	5.306978e-01	0.275	0
GRB2 events in EGFR signaling	R-HSA-179812	5.306978e-01	0.275	0
VLDLR internalisation and degradation	R-HSA-8866427	5.306978e-01	0.275	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.306978e-01	0.275	0
MET activates RAS signaling	R-HSA-8851805	5.306978e-01	0.275	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.306978e-01	0.275	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.306978e-01	0.275	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.306978e-01	0.275	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	5.306978e-01	0.275	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	5.306978e-01	0.275	0
OAS antiviral response	R-HSA-8983711	5.306978e-01	0.275	0
FCERI mediated MAPK activation	R-HSA-2871796	5.321294e-01	0.274	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	5.361968e-01	0.271	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	5.393036e-01	0.268	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.393326e-01	0.268	0
Signaling by NOTCH4	R-HSA-9013694	5.422215e-01	0.266	0
MITF-M-regulated melanocyte development	R-HSA-9730414	5.423247e-01	0.266	0
C-type lectin receptors (CLRs)	R-HSA-5621481	5.423547e-01	0.266	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	5.459021e-01	0.263	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	5.486165e-01	0.261	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	5.501541e-01	0.260	0
FGFR1 mutant receptor activation	R-HSA-1839124	5.501541e-01	0.260	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.501541e-01	0.260	0
Adenylate cyclase activating pathway	R-HSA-170660	5.523820e-01	0.258	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	5.523820e-01	0.258	0
CD28 dependent Vav1 pathway	R-HSA-389359	5.523820e-01	0.258	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	5.523820e-01	0.258	0
Frs2-mediated activation	R-HSA-170968	5.523820e-01	0.258	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	5.523820e-01	0.258	0
Diseases of nucleotide metabolism	R-HSA-9735804	5.523820e-01	0.258	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.523820e-01	0.258	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.523820e-01	0.258	0
Formation of axial mesoderm	R-HSA-9796292	5.523820e-01	0.258	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	5.523820e-01	0.258	0
Transmission across Chemical Synapses	R-HSA-112315	5.551817e-01	0.256	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	5.610862e-01	0.251	0
UCH proteinases	R-HSA-5689603	5.610862e-01	0.251	0
Glucagon signaling in metabolic regulation	R-HSA-163359	5.638131e-01	0.249	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.638131e-01	0.249	0
SARS-CoV-1 Infection	R-HSA-9678108	5.671956e-01	0.246	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	5.699986e-01	0.244	0
HDACs deacetylate histones	R-HSA-3214815	5.721309e-01	0.243	0
Signaling by NOTCH3	R-HSA-9012852	5.721309e-01	0.243	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	5.721476e-01	0.242	0
Retrograde neurotrophin signalling	R-HSA-177504	5.730655e-01	0.242	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.730655e-01	0.242	0
CRMPs in Sema3A signaling	R-HSA-399956	5.730655e-01	0.242	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.730655e-01	0.242	0
Regulation of KIT signaling	R-HSA-1433559	5.730655e-01	0.242	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	5.730655e-01	0.242	0
Signaling by FGFR4 in disease	R-HSA-5655291	5.730655e-01	0.242	0
Non-canonical inflammasome activation	R-HSA-9686114	5.730655e-01	0.242	0
Malate-aspartate shuttle	R-HSA-9856872	5.730655e-01	0.242	0
Signal regulatory protein family interactions	R-HSA-391160	5.730655e-01	0.242	0
P2Y receptors	R-HSA-417957	5.730655e-01	0.242	0
Zinc transporters	R-HSA-435354	5.730655e-01	0.242	0
SARS-CoV-2 Infection	R-HSA-9694516	5.754119e-01	0.240	0
Signaling by NOTCH2	R-HSA-1980145	5.771715e-01	0.239	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	5.771715e-01	0.239	0
Calnexin/calreticulin cycle	R-HSA-901042	5.771715e-01	0.239	0
NOD1/2 Signaling Pathway	R-HSA-168638	5.771715e-01	0.239	0
RNA Polymerase I Transcription	R-HSA-73864	5.795207e-01	0.237	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.827364e-01	0.235	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	5.827364e-01	0.235	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	5.827364e-01	0.235	0
G alpha (q) signalling events	R-HSA-416476	5.837224e-01	0.234	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.902280e-01	0.229	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	5.902280e-01	0.229	0
Influenza Infection	R-HSA-168255	5.914448e-01	0.228	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	5.927945e-01	0.227	0
G beta:gamma signalling through BTK	R-HSA-8964315	5.927945e-01	0.227	0
DCC mediated attractive signaling	R-HSA-418885	5.927945e-01	0.227	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	5.927945e-01	0.227	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.927945e-01	0.227	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.927945e-01	0.227	0
Dopamine clearance from the synaptic cleft	R-HSA-379401	5.927945e-01	0.227	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.927945e-01	0.227	0
p75NTR signals via NF-kB	R-HSA-193639	5.927945e-01	0.227	0
Processive synthesis on the lagging strand	R-HSA-69183	5.927945e-01	0.227	0
IRS-mediated signalling	R-HSA-112399	5.931734e-01	0.227	0
PRC2 methylates histones and DNA	R-HSA-212300	6.029820e-01	0.220	0
Disorders of transmembrane transporters	R-HSA-5619115	6.084186e-01	0.216	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	6.116130e-01	0.214	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.116130e-01	0.214	0
Prolonged ERK activation events	R-HSA-169893	6.116130e-01	0.214	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	6.116130e-01	0.214	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.116130e-01	0.214	0
Differentiation of T cells	R-HSA-9945266	6.116130e-01	0.214	0
Negative regulation of FLT3	R-HSA-9706369	6.116130e-01	0.214	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.116130e-01	0.214	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	6.135334e-01	0.212	0
Triglyceride metabolism	R-HSA-8979227	6.135334e-01	0.212	0
Chromosome Maintenance	R-HSA-73886	6.141243e-01	0.212	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.150208e-01	0.211	0
TCF dependent signaling in response to WNT	R-HSA-201681	6.150365e-01	0.211	0
Degradation of DVL	R-HSA-4641258	6.154335e-01	0.211	0
Voltage gated Potassium channels	R-HSA-1296072	6.154335e-01	0.211	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	6.154335e-01	0.211	0
Metabolism of RNA	R-HSA-8953854	6.154903e-01	0.211	0
PI Metabolism	R-HSA-1483255	6.178109e-01	0.209	0
HIV Infection	R-HSA-162906	6.189875e-01	0.208	0
GPCR downstream signalling	R-HSA-388396	6.270420e-01	0.203	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.275833e-01	0.202	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	6.295628e-01	0.201	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.295628e-01	0.201	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	6.295628e-01	0.201	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	6.295628e-01	0.201	0
Vitamin B6 activation to pyridoxal phosphate	R-HSA-964975	6.295628e-01	0.201	0
Passive transport by Aquaporins	R-HSA-432047	6.295628e-01	0.201	0
Galactose catabolism	R-HSA-70370	6.295628e-01	0.201	0
Opioid Signalling	R-HSA-111885	6.330327e-01	0.199	0
IRS-related events triggered by IGF1R	R-HSA-2428928	6.331967e-01	0.198	0
Aquaporin-mediated transport	R-HSA-445717	6.331967e-01	0.198	0
MAP kinase activation	R-HSA-450294	6.331967e-01	0.198	0
Formation of the cornified envelope	R-HSA-6809371	6.350451e-01	0.197	0
Stabilization of p53	R-HSA-69541	6.394326e-01	0.194	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.394326e-01	0.194	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	6.427639e-01	0.192	0
Mitochondrial protein import	R-HSA-1268020	6.427639e-01	0.192	0
Signaling by PDGF	R-HSA-186797	6.427639e-01	0.192	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	6.427639e-01	0.192	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.466842e-01	0.189	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.466842e-01	0.189	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.466842e-01	0.189	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.466842e-01	0.189	0
Uptake and function of anthrax toxins	R-HSA-5210891	6.466842e-01	0.189	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	6.509832e-01	0.186	0
Epigenetic regulation of gene expression	R-HSA-212165	6.538644e-01	0.185	0
XBP1(S) activates chaperone genes	R-HSA-381038	6.566817e-01	0.183	0
RNA Polymerase II Transcription	R-HSA-73857	6.569194e-01	0.182	0
Ion transport by P-type ATPases	R-HSA-936837	6.613661e-01	0.180	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	6.622375e-01	0.179	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.622375e-01	0.179	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	6.622375e-01	0.179	0
G beta:gamma signalling through PLC beta	R-HSA-418217	6.630151e-01	0.178	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.630151e-01	0.178	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	6.630151e-01	0.178	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.630151e-01	0.178	0
Presynaptic function of Kainate receptors	R-HSA-500657	6.630151e-01	0.178	0
Chaperone Mediated Autophagy	R-HSA-9613829	6.630151e-01	0.178	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	6.630151e-01	0.178	0
Vitamin D (calciferol) metabolism	R-HSA-196791	6.630151e-01	0.178	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	6.630151e-01	0.178	0
Biosynthesis of DHA-derived sulfido conjugates	R-HSA-9026395	6.630151e-01	0.178	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	6.630151e-01	0.178	0
Mismatch Repair	R-HSA-5358508	6.630151e-01	0.178	0
Antigen processing-Cross presentation	R-HSA-1236975	6.694258e-01	0.174	0
ESR-mediated signaling	R-HSA-8939211	6.695915e-01	0.174	0
Intra-Golgi traffic	R-HSA-6811438	6.731981e-01	0.172	0
PI-3K cascade:FGFR3	R-HSA-5654710	6.785922e-01	0.168	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.785922e-01	0.168	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	6.785922e-01	0.168	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.785922e-01	0.168	0
Translesion Synthesis by POLH	R-HSA-110320	6.785922e-01	0.168	0
Activation of GABAB receptors	R-HSA-991365	6.838681e-01	0.165	0
GABA B receptor activation	R-HSA-977444	6.838681e-01	0.165	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.838681e-01	0.165	0
DNA Double Strand Break Response	R-HSA-5693606	6.879356e-01	0.162	0
Kidney development	R-HSA-9830369	6.879356e-01	0.162	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	6.934502e-01	0.159	0
PI-3K cascade:FGFR4	R-HSA-5654720	6.934502e-01	0.159	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	6.934502e-01	0.159	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.934502e-01	0.159	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	6.934502e-01	0.159	0
Pregnenolone biosynthesis	R-HSA-196108	6.934502e-01	0.159	0
Signaling by NODAL	R-HSA-1181150	6.934502e-01	0.159	0
Defective pyroptosis	R-HSA-9710421	6.942511e-01	0.158	0
Transcriptional Regulation by MECP2	R-HSA-8986944	6.952003e-01	0.158	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	6.964372e-01	0.157	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	6.967780e-01	0.157	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	6.967780e-01	0.157	0
IRE1alpha activates chaperones	R-HSA-381070	7.025215e-01	0.153	0
Surfactant metabolism	R-HSA-5683826	7.043506e-01	0.152	0
Co-inhibition by PD-1	R-HSA-389948	7.068185e-01	0.151	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	7.076221e-01	0.150	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.076221e-01	0.150	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.076221e-01	0.150	0
ERK/MAPK targets	R-HSA-198753	7.076221e-01	0.150	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	7.076221e-01	0.150	0
Zygotic genome activation (ZGA)	R-HSA-9819196	7.076221e-01	0.150	0
Lagging Strand Synthesis	R-HSA-69186	7.076221e-01	0.150	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	7.076221e-01	0.150	0
Eukaryotic Translation Elongation	R-HSA-156842	7.097149e-01	0.149	0
Signaling by Insulin receptor	R-HSA-74752	7.097149e-01	0.149	0
Adaptive Immune System	R-HSA-1280218	7.114504e-01	0.148	0
COPII-mediated vesicle transport	R-HSA-204005	7.129118e-01	0.147	0
Interleukin-17 signaling	R-HSA-448424	7.129118e-01	0.147	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.141707e-01	0.146	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	7.141707e-01	0.146	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.141707e-01	0.146	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.141707e-01	0.146	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.141707e-01	0.146	0
NoRC negatively regulates rRNA expression	R-HSA-427413	7.208867e-01	0.142	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.208867e-01	0.142	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	7.208867e-01	0.142	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.211397e-01	0.142	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.211397e-01	0.142	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.211397e-01	0.142	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	7.211397e-01	0.142	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	7.211397e-01	0.142	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.237157e-01	0.140	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.237157e-01	0.140	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.237157e-01	0.140	0
Signaling by TGFBR3	R-HSA-9839373	7.237157e-01	0.140	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	7.287211e-01	0.137	0
Role of phospholipids in phagocytosis	R-HSA-2029485	7.287211e-01	0.137	0
Beta-catenin independent WNT signaling	R-HSA-3858494	7.290288e-01	0.137	0
Signaling by GPCR	R-HSA-372790	7.334523e-01	0.135	0
PI-3K cascade:FGFR1	R-HSA-5654689	7.340331e-01	0.134	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.340331e-01	0.134	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.340331e-01	0.134	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.340331e-01	0.134	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.340331e-01	0.134	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.340331e-01	0.134	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.340331e-01	0.134	0
Signaling by KIT in disease	R-HSA-9669938	7.340331e-01	0.134	0
mTORC1-mediated signalling	R-HSA-166208	7.340331e-01	0.134	0
LDL clearance	R-HSA-8964038	7.340331e-01	0.134	0
Fructose metabolism	R-HSA-5652084	7.340331e-01	0.134	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	7.340331e-01	0.134	0
RAF-independent MAPK1/3 activation	R-HSA-112409	7.340331e-01	0.134	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.340331e-01	0.134	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	7.346400e-01	0.134	0
Ca2+ pathway	R-HSA-4086398	7.363175e-01	0.133	0
Signaling by WNT	R-HSA-195721	7.372033e-01	0.132	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	7.419981e-01	0.130	0
Metal ion SLC transporters	R-HSA-425410	7.419981e-01	0.130	0
Signaling by FGFR in disease	R-HSA-1226099	7.437763e-01	0.129	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.463311e-01	0.127	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.463311e-01	0.127	0
Free fatty acids regulate insulin secretion	R-HSA-400451	7.463311e-01	0.127	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	7.463311e-01	0.127	0
Interleukin-20 family signaling	R-HSA-8854691	7.463311e-01	0.127	0
Growth hormone receptor signaling	R-HSA-982772	7.463311e-01	0.127	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	7.502085e-01	0.125	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	7.507450e-01	0.125	0
DNA Damage Bypass	R-HSA-73893	7.507450e-01	0.125	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.510660e-01	0.124	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.510660e-01	0.124	0
Post-translational protein phosphorylation	R-HSA-8957275	7.565177e-01	0.121	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.580612e-01	0.120	0
Deadenylation of mRNA	R-HSA-429947	7.580612e-01	0.120	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.580612e-01	0.120	0
TNFs bind their physiological receptors	R-HSA-5669034	7.580612e-01	0.120	0
Signaling by NOTCH1	R-HSA-1980143	7.581884e-01	0.120	0
Regulation of RAS by GAPs	R-HSA-5658442	7.592354e-01	0.120	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	7.612692e-01	0.118	0
HATs acetylate histones	R-HSA-3214847	7.627032e-01	0.118	0
Translation of Structural Proteins	R-HSA-9694635	7.651454e-01	0.116	0
Late Phase of HIV Life Cycle	R-HSA-162599	7.665720e-01	0.115	0
Hedgehog 'off' state	R-HSA-5610787	7.687658e-01	0.114	0
PI-3K cascade:FGFR2	R-HSA-5654695	7.692496e-01	0.114	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.692496e-01	0.114	0
G protein gated Potassium channels	R-HSA-1296059	7.692496e-01	0.114	0
Activation of G protein gated Potassium channels	R-HSA-1296041	7.692496e-01	0.114	0
ATP-dependent chromatin remodelers	R-HSA-9932444	7.692496e-01	0.114	0
SWI/SNF chromatin remodelers	R-HSA-9932451	7.692496e-01	0.114	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.692496e-01	0.114	0
Interleukin-7 signaling	R-HSA-1266695	7.692496e-01	0.114	0
Nuclear Receptor transcription pathway	R-HSA-383280	7.719387e-01	0.112	0
PCP/CE pathway	R-HSA-4086400	7.719387e-01	0.112	0
Integrin cell surface interactions	R-HSA-216083	7.719387e-01	0.112	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	7.754669e-01	0.110	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.754669e-01	0.110	0
RNA Polymerase I Promoter Escape	R-HSA-73772	7.754669e-01	0.110	0
Orc1 removal from chromatin	R-HSA-68949	7.754669e-01	0.110	0
Neurexins and neuroligins	R-HSA-6794361	7.754669e-01	0.110	0
Vesicle-mediated transport	R-HSA-5653656	7.755587e-01	0.110	0
MET activates PTK2 signaling	R-HSA-8874081	7.799211e-01	0.108	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.799211e-01	0.108	0
Metalloprotease DUBs	R-HSA-5689901	7.799211e-01	0.108	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.799211e-01	0.108	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.799211e-01	0.108	0
Suppression of phagosomal maturation	R-HSA-9637687	7.799211e-01	0.108	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.832183e-01	0.106	0
Regulation of PTEN stability and activity	R-HSA-8948751	7.832183e-01	0.106	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.850429e-01	0.105	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	7.885487e-01	0.103	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	7.900998e-01	0.102	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	7.900998e-01	0.102	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	7.900998e-01	0.102	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.900998e-01	0.102	0
Signaling by FGFR3 in disease	R-HSA-5655332	7.900998e-01	0.102	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.900998e-01	0.102	0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	7.900998e-01	0.102	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	7.900998e-01	0.102	0
Maturation of hRSV A proteins	R-HSA-9828806	7.900998e-01	0.102	0
Translation initiation complex formation	R-HSA-72649	7.907338e-01	0.102	0
Processing of DNA double-strand break ends	R-HSA-5693607	7.913580e-01	0.102	0
Interferon Signaling	R-HSA-913531	7.944684e-01	0.100	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	7.952595e-01	0.099	0
S Phase	R-HSA-69242	7.955656e-01	0.099	0
HCMV Early Events	R-HSA-9609690	7.957132e-01	0.099	0
Generic Transcription Pathway	R-HSA-212436	7.967275e-01	0.099	0
RSV-host interactions	R-HSA-9833110	7.972723e-01	0.098	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.980184e-01	0.098	0
G alpha (z) signalling events	R-HSA-418597	7.980184e-01	0.098	0
Paracetamol ADME	R-HSA-9753281	7.980184e-01	0.098	0
HIV elongation arrest and recovery	R-HSA-167287	7.998083e-01	0.097	0
Pausing and recovery of HIV elongation	R-HSA-167290	7.998083e-01	0.097	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	7.998083e-01	0.097	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	7.998083e-01	0.097	0
Formation of the Early Elongation Complex	R-HSA-113418	7.998083e-01	0.097	0
Telomere Extension By Telomerase	R-HSA-171319	7.998083e-01	0.097	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	7.998083e-01	0.097	0
G2/M Checkpoints	R-HSA-69481	8.001762e-01	0.097	0
Nucleotide Excision Repair	R-HSA-5696398	8.026203e-01	0.095	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	8.035253e-01	0.095	0
Ribosomal scanning and start codon recognition	R-HSA-72702	8.050776e-01	0.094	0
Late endosomal microautophagy	R-HSA-9615710	8.090683e-01	0.092	0
Termination of translesion DNA synthesis	R-HSA-5656169	8.090683e-01	0.092	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	8.093821e-01	0.092	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	8.093821e-01	0.092	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	8.114824e-01	0.091	0
Synthesis of PA	R-HSA-1483166	8.119165e-01	0.090	0
DNA Double-Strand Break Repair	R-HSA-5693532	8.175457e-01	0.087	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.179006e-01	0.087	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.179006e-01	0.087	0
Activation of BH3-only proteins	R-HSA-114452	8.179006e-01	0.087	0
Neurotransmitter clearance	R-HSA-112311	8.179006e-01	0.087	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.185404e-01	0.087	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.185404e-01	0.087	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.206540e-01	0.086	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	8.217104e-01	0.085	0
Deadenylation-dependent mRNA decay	R-HSA-429914	8.249546e-01	0.084	0
Extension of Telomeres	R-HSA-180786	8.249546e-01	0.084	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.263247e-01	0.083	0
Cargo concentration in the ER	R-HSA-5694530	8.263247e-01	0.083	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.263247e-01	0.083	0
Molecules associated with elastic fibres	R-HSA-2129379	8.263247e-01	0.083	0
Golgi-to-ER retrograde transport	R-HSA-8856688	8.277434e-01	0.082	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	8.311643e-01	0.080	0
GABA receptor activation	R-HSA-977443	8.311643e-01	0.080	0
Kinesins	R-HSA-983189	8.311643e-01	0.080	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	8.311643e-01	0.080	0
Chaperonin-mediated protein folding	R-HSA-390466	8.313533e-01	0.080	0
HCMV Late Events	R-HSA-9610379	8.337536e-01	0.079	0
DNA strand elongation	R-HSA-69190	8.343597e-01	0.079	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	8.343597e-01	0.079	0
Peptide chain elongation	R-HSA-156902	8.364944e-01	0.078	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.371747e-01	0.077	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.420234e-01	0.075	0
Nuclear RNA decay	R-HSA-9930044	8.420234e-01	0.075	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.420234e-01	0.075	0
Cardiogenesis	R-HSA-9733709	8.420234e-01	0.075	0
Regulation of MECP2 expression and activity	R-HSA-9022692	8.420234e-01	0.075	0
Signaling by TGFB family members	R-HSA-9006936	8.451355e-01	0.073	0
Integration of energy metabolism	R-HSA-163685	8.482878e-01	0.071	0
Acyl chain remodelling of PC	R-HSA-1482788	8.493329e-01	0.071	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	8.493329e-01	0.071	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	8.500146e-01	0.071	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	8.511141e-01	0.070	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	8.557280e-01	0.068	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	8.563047e-01	0.067	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	8.563047e-01	0.067	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	8.563047e-01	0.067	0
Signal amplification	R-HSA-392518	8.563047e-01	0.067	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.602164e-01	0.065	0
Protein folding	R-HSA-391251	8.602164e-01	0.065	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.602164e-01	0.065	0
Acyl chain remodelling of PE	R-HSA-1482839	8.629543e-01	0.064	0
FCGR activation	R-HSA-2029481	8.645819e-01	0.063	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.692965e-01	0.061	0
RNA Polymerase III Transcription	R-HSA-74158	8.692965e-01	0.061	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.692965e-01	0.061	0
Glycosphingolipid transport	R-HSA-9845576	8.692965e-01	0.061	0
HSF1 activation	R-HSA-3371511	8.692965e-01	0.061	0
Triglyceride catabolism	R-HSA-163560	8.692965e-01	0.061	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.692965e-01	0.061	0
Homology Directed Repair	R-HSA-5693538	8.698626e-01	0.061	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	8.729543e-01	0.059	0
SLC-mediated transport of organic cations	R-HSA-549127	8.753456e-01	0.058	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	8.753456e-01	0.058	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	8.753456e-01	0.058	0
Formation of a pool of free 40S subunits	R-HSA-72689	8.769663e-01	0.057	0
Eukaryotic Translation Termination	R-HSA-72764	8.769663e-01	0.057	0
Phospholipid metabolism	R-HSA-1483257	8.783322e-01	0.056	0
Organelle biogenesis and maintenance	R-HSA-1852241	8.789493e-01	0.056	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	8.808656e-01	0.055	0
COPI-mediated anterograde transport	R-HSA-6807878	8.808656e-01	0.055	0
Purine salvage	R-HSA-74217	8.811151e-01	0.055	0
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	8.811151e-01	0.055	0
Elastic fibre formation	R-HSA-1566948	8.811151e-01	0.055	0
G alpha (s) signalling events	R-HSA-418555	8.844757e-01	0.053	0
Telomere Maintenance	R-HSA-157579	8.846545e-01	0.053	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	8.866179e-01	0.052	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	8.866179e-01	0.052	0
Plasma lipoprotein clearance	R-HSA-8964043	8.866179e-01	0.052	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	8.866179e-01	0.052	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.866179e-01	0.052	0
MHC class II antigen presentation	R-HSA-2132295	8.874085e-01	0.052	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	8.874172e-01	0.052	0
Hedgehog 'on' state	R-HSA-5632684	8.874172e-01	0.052	0
Cellular responses to stimuli	R-HSA-8953897	8.875642e-01	0.052	0
Regulation of insulin secretion	R-HSA-422356	8.883356e-01	0.051	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	8.901368e-01	0.051	0
Leishmania parasite growth and survival	R-HSA-9664433	8.901368e-01	0.051	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.915607e-01	0.050	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.915607e-01	0.050	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	8.915607e-01	0.050	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	8.918663e-01	0.050	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	8.918663e-01	0.050	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	8.918663e-01	0.050	0
HIV Transcription Elongation	R-HSA-167169	8.918663e-01	0.050	0
Aggrephagy	R-HSA-9646399	8.918663e-01	0.050	0
Attenuation phase	R-HSA-3371568	8.918663e-01	0.050	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.918663e-01	0.050	0
Generation of second messenger molecules	R-HSA-202433	8.918663e-01	0.050	0
Glycogen metabolism	R-HSA-8982491	8.918663e-01	0.050	0
ABC-family proteins mediated transport	R-HSA-382556	8.953841e-01	0.048	0
Switching of origins to a post-replicative state	R-HSA-69052	8.955622e-01	0.048	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.968720e-01	0.047	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	8.968720e-01	0.047	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.968720e-01	0.047	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.968720e-01	0.047	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	8.969149e-01	0.047	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	8.969149e-01	0.047	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	8.969149e-01	0.047	0
Selenocysteine synthesis	R-HSA-2408557	8.987564e-01	0.046	0
Cellular responses to stress	R-HSA-2262752	9.004638e-01	0.046	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.016464e-01	0.045	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.016464e-01	0.045	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.016464e-01	0.045	0
Heme biosynthesis	R-HSA-189451	9.016464e-01	0.045	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	9.016464e-01	0.045	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.016464e-01	0.045	0
Translation of Structural Proteins	R-HSA-9683701	9.016464e-01	0.045	0
Regulation of endogenous retroelements	R-HSA-9842860	9.020304e-01	0.045	0
Viral mRNA Translation	R-HSA-192823	9.052087e-01	0.043	0
Protein localization	R-HSA-9609507	9.061144e-01	0.043	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.061999e-01	0.043	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.061999e-01	0.043	0
MTOR signalling	R-HSA-165159	9.061999e-01	0.043	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.061999e-01	0.043	0
rRNA processing	R-HSA-72312	9.081957e-01	0.042	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.082934e-01	0.042	0
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.105430e-01	0.041	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.105430e-01	0.041	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.105430e-01	0.041	0
ABC transporter disorders	R-HSA-5619084	9.135859e-01	0.039	0
Interleukin-10 signaling	R-HSA-6783783	9.135859e-01	0.039	0
RMTs methylate histone arginines	R-HSA-3214858	9.146851e-01	0.039	0
Asymmetric localization of PCP proteins	R-HSA-4608870	9.186358e-01	0.037	0
Somitogenesis	R-HSA-9824272	9.186358e-01	0.037	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.186358e-01	0.037	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.186358e-01	0.037	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.197425e-01	0.036	0
Synthesis of DNA	R-HSA-69239	9.197425e-01	0.036	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.223933e-01	0.035	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.223933e-01	0.035	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.224037e-01	0.035	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.224037e-01	0.035	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.224037e-01	0.035	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.259973e-01	0.033	0
Synthesis of PC	R-HSA-1483191	9.259973e-01	0.033	0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.259973e-01	0.033	0
NGF-stimulated transcription	R-HSA-9031628	9.294248e-01	0.032	0
Estrogen-dependent gene expression	R-HSA-9018519	9.304051e-01	0.031	0
Gap junction trafficking and regulation	R-HSA-157858	9.326936e-01	0.030	0
Chemokine receptors bind chemokines	R-HSA-380108	9.326936e-01	0.030	0
Ribosome-associated quality control	R-HSA-9948299	9.345810e-01	0.029	0
Signaling by Hedgehog	R-HSA-5358351	9.345810e-01	0.029	0
Signaling by FGFR2 in disease	R-HSA-5655253	9.358113e-01	0.029	0
Unfolded Protein Response (UPR)	R-HSA-381119	9.365827e-01	0.028	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	9.366836e-01	0.028	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.387847e-01	0.027	0
Activation of NF-kappaB in B cells	R-HSA-1169091	9.387847e-01	0.027	0
The phototransduction cascade	R-HSA-2514856	9.387847e-01	0.027	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	9.388940e-01	0.027	0
HCMV Infection	R-HSA-9609646	9.403417e-01	0.027	0
Pyruvate metabolism	R-HSA-70268	9.412259e-01	0.026	0
Formation of RNA Pol II elongation complex	R-HSA-112382	9.416206e-01	0.026	0
Uptake and actions of bacterial toxins	R-HSA-5339562	9.416206e-01	0.026	0
Interferon alpha/beta signaling	R-HSA-909733	9.428795e-01	0.026	0
tRNA processing	R-HSA-72306	9.437060e-01	0.025	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.440172e-01	0.025	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	9.443253e-01	0.025	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	9.443253e-01	0.025	0
Meiotic synapsis	R-HSA-1221632	9.443253e-01	0.025	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	9.443253e-01	0.025	0
Amino acids regulate mTORC1	R-HSA-9639288	9.443253e-01	0.025	0
Nucleotide biosynthesis	R-HSA-8956320	9.443253e-01	0.025	0
Eukaryotic Translation Initiation	R-HSA-72613	9.448167e-01	0.025	0
Cap-dependent Translation Initiation	R-HSA-72737	9.448167e-01	0.025	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.469048e-01	0.024	0
Neurotransmitter release cycle	R-HSA-112310	9.477245e-01	0.023	0
Base Excision Repair	R-HSA-73884	9.477245e-01	0.023	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.504784e-01	0.022	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	9.517112e-01	0.021	0
ER to Golgi Anterograde Transport	R-HSA-199977	9.522434e-01	0.021	0
Dectin-2 family	R-HSA-5621480	9.539489e-01	0.020	0
Keratinization	R-HSA-6805567	9.557194e-01	0.020	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	9.560831e-01	0.020	0
Dual incision in TC-NER	R-HSA-6782135	9.560831e-01	0.020	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.560831e-01	0.020	0
Peroxisomal protein import	R-HSA-9033241	9.581184e-01	0.019	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.593241e-01	0.018	0
tRNA Aminoacylation	R-HSA-379724	9.600596e-01	0.018	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	9.600596e-01	0.018	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.600596e-01	0.018	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	9.600596e-01	0.018	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	9.600596e-01	0.018	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	9.600596e-01	0.018	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	9.600596e-01	0.018	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.603279e-01	0.018	0
Formation of paraxial mesoderm	R-HSA-9793380	9.619109e-01	0.017	0
Nucleotide salvage	R-HSA-8956321	9.619109e-01	0.017	0
Endogenous sterols	R-HSA-211976	9.619109e-01	0.017	0
Collagen degradation	R-HSA-1442490	9.619109e-01	0.017	0
Cellular response to chemical stress	R-HSA-9711123	9.621497e-01	0.017	0
PPARA activates gene expression	R-HSA-1989781	9.630932e-01	0.016	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.636765e-01	0.016	0
Post-translational protein modification	R-HSA-597592	9.643122e-01	0.016	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.654230e-01	0.015	0
Cellular response to starvation	R-HSA-9711097	9.665360e-01	0.015	0
G alpha (i) signalling events	R-HSA-418594	9.665565e-01	0.015	0
CD22 mediated BCR regulation	R-HSA-5690714	9.669662e-01	0.015	0
Xenobiotics	R-HSA-211981	9.669662e-01	0.015	0
Cellular response to hypoxia	R-HSA-1234174	9.684978e-01	0.014	0
Drug ADME	R-HSA-9748784	9.685678e-01	0.014	0
Reproduction	R-HSA-1474165	9.685732e-01	0.014	0
DNA Repair	R-HSA-73894	9.704278e-01	0.013	0
Neddylation	R-HSA-8951664	9.711949e-01	0.013	0
Metabolism of steroid hormones	R-HSA-196071	9.713514e-01	0.013	0
Signaling by Nuclear Receptors	R-HSA-9006931	9.724718e-01	0.012	0
Selenoamino acid metabolism	R-HSA-2408522	9.725428e-01	0.012	0
Transcription of the HIV genome	R-HSA-167172	9.726799e-01	0.012	0
Activation of HOX genes during differentiation	R-HSA-5619507	9.733951e-01	0.012	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	9.733951e-01	0.012	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.738307e-01	0.012	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.751551e-01	0.011	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.751551e-01	0.011	0
Disease	R-HSA-1643685	9.752722e-01	0.011	0
ECM proteoglycans	R-HSA-3000178	9.763074e-01	0.010	0
Metabolism of porphyrins	R-HSA-189445	9.763074e-01	0.010	0
Purine catabolism	R-HSA-74259	9.774063e-01	0.010	0
TCR signaling	R-HSA-202403	9.791237e-01	0.009	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	9.794538e-01	0.009	0
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.794538e-01	0.009	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.804070e-01	0.009	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.821828e-01	0.008	0
Cholesterol biosynthesis	R-HSA-191273	9.830095e-01	0.007	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.830095e-01	0.007	0
Viral Infection Pathways	R-HSA-9824446	9.844505e-01	0.007	0
Amyloid fiber formation	R-HSA-977225	9.852668e-01	0.006	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.852668e-01	0.006	0
Peptide hormone metabolism	R-HSA-2980736	9.855391e-01	0.006	0
Mitochondrial biogenesis	R-HSA-1592230	9.855391e-01	0.006	0
Peroxisomal lipid metabolism	R-HSA-390918	9.872245e-01	0.006	0
DNA Replication	R-HSA-69306	9.874158e-01	0.005	0
Meiosis	R-HSA-1500620	9.878176e-01	0.005	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	9.887027e-01	0.005	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.899272e-01	0.004	0
Downstream TCR signaling	R-HSA-202424	9.908409e-01	0.004	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.928294e-01	0.003	0
Degradation of the extracellular matrix	R-HSA-1474228	9.928437e-01	0.003	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.931147e-01	0.003	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.934448e-01	0.003	0
Infectious disease	R-HSA-5663205	9.934980e-01	0.003	0
Mitochondrial translation elongation	R-HSA-5389840	9.937396e-01	0.003	0
Transport of small molecules	R-HSA-382551	9.938082e-01	0.003	0
Mitochondrial translation initiation	R-HSA-5368286	9.943078e-01	0.002	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.945723e-01	0.002	0
SLC-mediated transmembrane transport	R-HSA-425407	9.946937e-01	0.002	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.955131e-01	0.002	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.960238e-01	0.002	0
Peptide ligand-binding receptors	R-HSA-375276	9.965672e-01	0.001	0
Mitochondrial translation termination	R-HSA-5419276	9.967847e-01	0.001	0
Bile acid and bile salt metabolism	R-HSA-194068	9.969342e-01	0.001	0
Antimicrobial peptides	R-HSA-6803157	9.970768e-01	0.001	0
Extracellular matrix organization	R-HSA-1474244	9.974863e-01	0.001	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.975819e-01	0.001	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.976166e-01	0.001	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.976963e-01	0.001	0
Interferon gamma signaling	R-HSA-877300	9.978966e-01	0.001	0
Phase II - Conjugation of compounds	R-HSA-156580	9.982045e-01	0.001	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.983496e-01	0.001	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.983496e-01	0.001	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.984997e-01	0.001	0
Regulation of Complement cascade	R-HSA-977606	9.986361e-01	0.001	0
Nucleotide catabolism	R-HSA-8956319	9.989254e-01	0.000	0
Sensory perception of taste	R-HSA-9717189	9.990686e-01	0.000	0
Circadian clock	R-HSA-9909396	9.991120e-01	0.000	0
Diseases of glycosylation	R-HSA-3781865	9.993127e-01	0.000	0
Mitochondrial translation	R-HSA-5368287	9.993641e-01	0.000	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.995225e-01	0.000	0
Complement cascade	R-HSA-166658	9.995659e-01	0.000	0
Visual phototransduction	R-HSA-2187338	9.996055e-01	0.000	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.998483e-01	0.000	0
Bacterial Infection Pathways	R-HSA-9824439	9.999032e-01	0.000	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999084e-01	0.000	0
Translation	R-HSA-72766	9.999133e-01	0.000	0
Respiratory electron transport	R-HSA-611105	9.999145e-01	0.000	0
Metabolism of nucleotides	R-HSA-15869	9.999328e-01	0.000	0
Metabolism of steroids	R-HSA-8957322	9.999331e-01	0.000	0
Asparagine N-linked glycosylation	R-HSA-446203	9.999706e-01	0.000	0
Sphingolipid metabolism	R-HSA-428157	9.999716e-01	0.000	0
Metabolism of proteins	R-HSA-392499	9.999775e-01	0.000	0
GPCR ligand binding	R-HSA-500792	9.999876e-01	0.000	0
Phase I - Functionalization of compounds	R-HSA-211945	9.999897e-01	0.000	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999933e-01	0.000	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999945e-01	0.000	0
Biological oxidations	R-HSA-211859	9.999994e-01	0.000	0
Fatty acid metabolism	R-HSA-8978868	9.999997e-01	0.000	0
Diseases of metabolism	R-HSA-5668914	9.999999e-01	0.000	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000	0
Sensory Perception	R-HSA-9709957	1.000000e+00	0.000	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path
M Phase	R-HSA-68886	1.110223e-16	15.955	0
Cell-Cell communication	R-HSA-1500931	1.110223e-16	15.955	0
Cell Cycle	R-HSA-1640170	8.881784e-16	15.051	0
Cell junction organization	R-HSA-446728	7.771561e-16	15.109	0
Cell Cycle, Mitotic	R-HSA-69278	4.884981e-15	14.311	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.632028e-14	13.787	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.632028e-14	13.787	0
HDACs deacetylate histones	R-HSA-3214815	3.597123e-14	13.444	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.130030e-14	13.384	0
Transcriptional regulation by small RNAs	R-HSA-5578749	1.491030e-13	12.827	0
Adherens junctions interactions	R-HSA-418990	3.345102e-13	12.476	0
Cell-cell junction organization	R-HSA-421270	6.101786e-13	12.215	0
Mitotic Anaphase	R-HSA-68882	9.503509e-13	12.022	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.093015e-12	11.961	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.032463e-12	11.518	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.530287e-12	11.452	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.030554e-12	11.395	0
Nucleosome assembly	R-HSA-774815	4.030554e-12	11.395	0
Cell Cycle Checkpoints	R-HSA-69620	5.136003e-12	11.289	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	5.661138e-12	11.247	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	7.515211e-12	11.124	0
Mitotic Prophase	R-HSA-68875	7.525314e-12	11.123	0
Gene Silencing by RNA	R-HSA-211000	9.294787e-12	11.032	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	8.940071e-12	11.049	0
Cellular responses to stress	R-HSA-2262752	9.031553e-12	11.044	0
Cellular responses to stimuli	R-HSA-8953897	1.226741e-11	10.911	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.788914e-11	10.555	0
Chromatin modifying enzymes	R-HSA-3247509	3.607270e-11	10.443	0
Axon guidance	R-HSA-422475	4.207945e-11	10.376	0
Cytokine Signaling in Immune system	R-HSA-1280215	4.540956e-11	10.343	0
Meiotic synapsis	R-HSA-1221632	5.171819e-11	10.286	0
Packaging Of Telomere Ends	R-HSA-171306	8.105883e-11	10.091	0
RNA Polymerase I Promoter Opening	R-HSA-73728	8.105883e-11	10.091	0
Interleukin-12 signaling	R-HSA-9020591	9.465506e-11	10.024	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.052809e-10	9.978	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.081116e-10	9.966	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.270838e-10	9.896	0
Cellular response to heat stress	R-HSA-3371556	1.828665e-10	9.738	0
DNA methylation	R-HSA-5334118	1.881937e-10	9.725	0
Chromatin organization	R-HSA-4839726	2.115567e-10	9.675	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.316501e-10	9.635	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.604824e-10	9.584	0
Separation of Sister Chromatids	R-HSA-2467813	2.587252e-10	9.587	0
Interleukin-12 family signaling	R-HSA-447115	2.563073e-10	9.591	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.748124e-10	9.561	0
Signal Transduction	R-HSA-162582	2.742321e-10	9.562	1
PRC2 methylates histones and DNA	R-HSA-212300	4.538495e-10	9.343	0
HCMV Early Events	R-HSA-9609690	4.561245e-10	9.341	0
G2/M Checkpoints	R-HSA-69481	5.858853e-10	9.232	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	6.046263e-10	9.219	0
Nervous system development	R-HSA-9675108	6.297221e-10	9.201	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	6.383738e-10	9.195	0
Chaperone Mediated Autophagy	R-HSA-9613829	7.738004e-10	9.111	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	8.904772e-10	9.050	0
NoRC negatively regulates rRNA expression	R-HSA-427413	9.016855e-10	9.045	0
Ub-specific processing proteases	R-HSA-5689880	1.016536e-09	8.993	0
Assembly of the pre-replicative complex	R-HSA-68867	1.047994e-09	8.980	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.234319e-09	8.909	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.278907e-09	8.893	0
Viral Infection Pathways	R-HSA-9824446	1.353677e-09	8.868	0
Selective autophagy	R-HSA-9663891	1.559015e-09	8.807	0
Aggrephagy	R-HSA-9646399	1.687933e-09	8.773	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.687933e-09	8.773	0
G2/M DNA damage checkpoint	R-HSA-69473	1.761877e-09	8.754	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.757738e-09	8.755	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.102772e-09	8.677	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	2.297396e-09	8.639	0
Co-inhibition by PD-1	R-HSA-389948	2.519255e-09	8.599	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.224261e-09	8.492	0
Mitotic Prometaphase	R-HSA-68877	3.632518e-09	8.440	0
HATs acetylate histones	R-HSA-3214847	3.817244e-09	8.418	0
Cleavage of the damaged purine	R-HSA-110331	4.689741e-09	8.329	0
Defective pyroptosis	R-HSA-9710421	5.548503e-09	8.256	0
Regulation of CDH1 Function	R-HSA-9764561	5.814452e-09	8.235	0
Interferon Signaling	R-HSA-913531	6.250858e-09	8.204	0
Depurination	R-HSA-73927	6.394565e-09	8.194	0
Amyloid fiber formation	R-HSA-977225	7.526694e-09	8.123	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	9.361056e-09	8.029	0
Metabolism of RNA	R-HSA-8953854	9.423222e-09	8.026	0
RNA Polymerase I Promoter Escape	R-HSA-73772	9.839507e-09	8.007	0
Estrogen-dependent gene expression	R-HSA-9018519	1.191538e-08	7.924	0
Condensation of Prophase Chromosomes	R-HSA-2299718	1.263434e-08	7.898	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.548125e-08	7.810	0
Meiosis	R-HSA-1500620	1.621077e-08	7.790	0
ESR-mediated signaling	R-HSA-8939211	1.649118e-08	7.783	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.985655e-08	7.702	0
SARS-CoV-2-host interactions	R-HSA-9705683	1.965639e-08	7.706	0
RNA Polymerase I Transcription	R-HSA-73864	2.011907e-08	7.696	0
HCMV Infection	R-HSA-9609646	2.047166e-08	7.689	0
DNA Replication Pre-Initiation	R-HSA-69002	2.382614e-08	7.623	0
Cleavage of the damaged pyrimidine	R-HSA-110329	2.694682e-08	7.569	0
Depyrimidination	R-HSA-73928	2.694682e-08	7.569	0
Regulation of endogenous retroelements	R-HSA-9842860	2.729446e-08	7.564	0
Oxidative Stress Induced Senescence	R-HSA-2559580	2.729446e-08	7.564	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	3.157041e-08	7.501	0
Deubiquitination	R-HSA-5688426	3.315074e-08	7.480	0
Diseases of programmed cell death	R-HSA-9645723	3.352285e-08	7.475	0
Regulation of T cell activation by CD28 family	R-HSA-388841	3.644733e-08	7.438	0
Meiotic recombination	R-HSA-912446	4.443236e-08	7.352	0
DNA Double Strand Break Response	R-HSA-5693606	5.359978e-08	7.271	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.482534e-08	7.188	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	6.559276e-08	7.183	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.601049e-08	7.018	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	9.601049e-08	7.018	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.111294e-07	6.954	0
Signaling by EGFR	R-HSA-177929	1.382653e-07	6.859	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.427022e-07	6.846	0
Autophagy	R-HSA-9612973	1.729118e-07	6.762	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.910921e-07	6.719	0
ISG15 antiviral mechanism	R-HSA-1169408	2.470288e-07	6.607	0
Macroautophagy	R-HSA-1632852	2.833472e-07	6.548	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.593018e-07	6.445	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	4.653886e-07	6.332	0
Recycling pathway of L1	R-HSA-437239	5.360977e-07	6.271	0
PKR-mediated signaling	R-HSA-9833482	5.855522e-07	6.232	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	6.468121e-07	6.189	0
Chromosome Maintenance	R-HSA-73886	6.488688e-07	6.188	0
HCMV Late Events	R-HSA-9610379	6.194503e-07	6.208	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	6.687442e-07	6.175	0
Influenza Infection	R-HSA-168255	7.527843e-07	6.123	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	8.356463e-07	6.078	0
SARS-CoV-1-host interactions	R-HSA-9692914	8.759925e-07	6.057	0
Host Interactions of HIV factors	R-HSA-162909	9.465007e-07	6.024	0
Apoptosis	R-HSA-109581	1.060910e-06	5.974	0
TCF dependent signaling in response to WNT	R-HSA-201681	1.122131e-06	5.950	0
Eukaryotic Translation Elongation	R-HSA-156842	1.285695e-06	5.891	0
HSF1-dependent transactivation	R-HSA-3371571	1.262278e-06	5.899	0
DNA Replication	R-HSA-69306	1.248829e-06	5.903	0
Programmed Cell Death	R-HSA-5357801	1.231844e-06	5.909	0
Cell-extracellular matrix interactions	R-HSA-446353	1.321326e-06	5.879	0
Signaling by NOTCH	R-HSA-157118	1.345774e-06	5.871	0
Homology Directed Repair	R-HSA-5693538	1.534825e-06	5.814	0
Metalloprotease DUBs	R-HSA-5689901	1.999770e-06	5.699	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	2.186787e-06	5.660	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.417612e-06	5.617	0
Activation of HOX genes during differentiation	R-HSA-5619507	2.417612e-06	5.617	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	2.419706e-06	5.616	0
Attenuation phase	R-HSA-3371568	2.591791e-06	5.586	0
Signaling by ROBO receptors	R-HSA-376176	2.592719e-06	5.586	0
Transcriptional regulation by RUNX1	R-HSA-8878171	2.877863e-06	5.541	0
Processing of DNA double-strand break ends	R-HSA-5693607	2.822276e-06	5.549	0
Base Excision Repair	R-HSA-73884	3.179893e-06	5.498	0
SARS-CoV-2 Infection	R-HSA-9694516	3.475941e-06	5.459	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.691737e-06	5.433	0
Signaling by RAF1 mutants	R-HSA-9656223	4.041455e-06	5.393	0
Cap-dependent Translation Initiation	R-HSA-72737	4.056278e-06	5.392	0
Eukaryotic Translation Initiation	R-HSA-72613	4.056278e-06	5.392	0
Late endosomal microautophagy	R-HSA-9615710	4.636719e-06	5.334	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.647116e-06	5.333	0
EPH-Ephrin signaling	R-HSA-2682334	4.832391e-06	5.316	0
HSF1 activation	R-HSA-3371511	5.705748e-06	5.244	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	5.705748e-06	5.244	0
UCH proteinases	R-HSA-5689603	5.236494e-06	5.281	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	5.347119e-06	5.272	0
SARS-CoV Infections	R-HSA-9679506	6.441437e-06	5.191	0
Signaling by Interleukins	R-HSA-449147	6.907311e-06	5.161	0
Signaling by WNT	R-HSA-195721	7.342081e-06	5.134	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	7.380882e-06	5.132	0
Epigenetic regulation of gene expression	R-HSA-212165	7.437674e-06	5.129	0
Immune System	R-HSA-168256	7.926453e-06	5.101	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	8.348053e-06	5.078	0
Developmental Biology	R-HSA-1266738	9.083269e-06	5.042	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.009099e-05	4.996	0
Signaling by RAS mutants	R-HSA-6802949	1.120386e-05	4.951	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.120386e-05	4.951	0
Signaling downstream of RAS mutants	R-HSA-9649948	1.120386e-05	4.951	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.120386e-05	4.951	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.082788e-05	4.965	0
G2/M Transition	R-HSA-69275	1.156659e-05	4.937	0
Spry regulation of FGF signaling	R-HSA-1295596	1.185101e-05	4.926	0
DNA Double-Strand Break Repair	R-HSA-5693532	1.111550e-05	4.954	0
Telomere Maintenance	R-HSA-157579	1.063477e-05	4.973	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.257362e-05	4.901	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.258651e-05	4.900	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.314892e-05	4.881	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.334648e-05	4.875	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.357141e-05	4.867	0
Mitotic G2-G2/M phases	R-HSA-453274	1.373381e-05	4.862	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.583076e-05	4.800	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.594356e-05	4.797	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.594356e-05	4.797	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.772955e-05	4.751	0
Oncogenic MAPK signaling	R-HSA-6802957	1.895802e-05	4.722	0
Ribosome-associated quality control	R-HSA-9948299	1.961423e-05	4.707	0
Nuclear import of Rev protein	R-HSA-180746	1.979543e-05	4.703	0
Infectious disease	R-HSA-5663205	2.039996e-05	4.690	0
Amplification of signal from the kinetochores	R-HSA-141424	2.164537e-05	4.665	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.164537e-05	4.665	0
Reproduction	R-HSA-1474165	2.351751e-05	4.629	0
MAPK family signaling cascades	R-HSA-5683057	3.324811e-05	4.478	0
SARS-CoV-1 Infection	R-HSA-9678108	3.199671e-05	4.495	0
RMTs methylate histone arginines	R-HSA-3214858	3.610172e-05	4.442	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	3.726266e-05	4.429	0
L1CAM interactions	R-HSA-373760	4.098903e-05	4.387	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.348381e-05	4.362	0
EGFR downregulation	R-HSA-182971	4.395148e-05	4.357	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	4.395148e-05	4.357	0
FLT3 signaling by CBL mutants	R-HSA-9706377	4.615146e-05	4.336	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.782371e-05	4.320	0
Cellular Senescence	R-HSA-2559583	4.831277e-05	4.316	0
Glycolysis	R-HSA-70171	5.074854e-05	4.295	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	5.200386e-05	4.284	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.471115e-05	4.262	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	5.519601e-05	4.258	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	5.519601e-05	4.258	0
Membrane Trafficking	R-HSA-199991	6.521893e-05	4.186	0
MAPK6/MAPK4 signaling	R-HSA-5687128	6.652882e-05	4.177	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	6.653974e-05	4.177	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	6.653974e-05	4.177	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	6.664991e-05	4.176	0
Interactions of Rev with host cellular proteins	R-HSA-177243	6.664991e-05	4.176	0
Signaling by EGFR in Cancer	R-HSA-1643713	7.777389e-05	4.109	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.495754e-05	4.071	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	8.608625e-05	4.065	0
Degradation of CDH1	R-HSA-9766229	8.533618e-05	4.069	0
Signaling by Nuclear Receptors	R-HSA-9006931	8.195706e-05	4.086	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	8.933396e-05	4.049	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.032677e-05	4.044	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	9.223726e-05	4.035	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.247726e-05	4.034	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.256334e-05	4.034	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	9.467239e-05	4.024	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	9.467239e-05	4.024	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	9.467239e-05	4.024	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	9.467239e-05	4.024	0
Post NMDA receptor activation events	R-HSA-438064	9.544887e-05	4.020	0
MAP2K and MAPK activation	R-HSA-5674135	9.576559e-05	4.019	0
Peptide chain elongation	R-HSA-156902	1.072766e-04	3.969	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.072766e-04	3.969	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.100271e-04	3.959	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.100271e-04	3.959	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.100271e-04	3.959	0
HIV Infection	R-HSA-162906	1.152248e-04	3.938	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.230177e-04	3.910	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.331853e-04	3.876	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.355065e-04	3.868	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.412212e-04	3.850	0
Mitotic Spindle Checkpoint	R-HSA-69618	1.583818e-04	3.800	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.781066e-04	3.749	0
Translation initiation complex formation	R-HSA-72649	1.839406e-04	3.735	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.858710e-04	3.731	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.300885e-04	3.638	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	2.186264e-04	3.660	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.269007e-04	3.644	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.269007e-04	3.644	0
Protein ubiquitination	R-HSA-8852135	2.261244e-04	3.646	0
Signaling by Hippo	R-HSA-2028269	2.300885e-04	3.638	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.126343e-04	3.672	0
Signaling by NOTCH4	R-HSA-9013694	2.003282e-04	3.698	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.965360e-04	3.707	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.161008e-04	3.665	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.194646e-04	3.659	0
Apoptotic execution phase	R-HSA-75153	2.194646e-04	3.659	0
Late Phase of HIV Life Cycle	R-HSA-162599	2.334830e-04	3.632	0
Regulation of PTEN localization	R-HSA-8948747	2.405128e-04	3.619	0
Ribosomal scanning and start codon recognition	R-HSA-72702	2.445290e-04	3.612	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.577424e-04	3.589	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	2.711019e-04	3.567	0
IRAK1 recruits IKK complex	R-HSA-937039	2.711019e-04	3.567	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.986954e-04	3.525	0
Translation	R-HSA-72766	2.994169e-04	3.524	0
Transport of connexons to the plasma membrane	R-HSA-190872	2.999582e-04	3.523	0
HIV Life Cycle	R-HSA-162587	3.003667e-04	3.522	0
IPs transport between nucleus and cytosol	R-HSA-1855170	3.316660e-04	3.479	0
MAPK1/MAPK3 signaling	R-HSA-5684996	3.334635e-04	3.477	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.492792e-04	3.457	0
Signaling by ALK in cancer	R-HSA-9700206	3.492792e-04	3.457	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	3.516002e-04	3.454	0
Metabolism of non-coding RNA	R-HSA-194441	3.667924e-04	3.436	0
snRNP Assembly	R-HSA-191859	3.667924e-04	3.436	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	3.706532e-04	3.431	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	3.706532e-04	3.431	0
Downregulation of ERBB4 signaling	R-HSA-1253288	3.706532e-04	3.431	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.706532e-04	3.431	0
Glucose metabolism	R-HSA-70326	3.742311e-04	3.427	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	3.973996e-04	3.401	0
Regulation of RAS by GAPs	R-HSA-5658442	3.978247e-04	3.400	0
Negative regulation of MAPK pathway	R-HSA-5675221	4.120930e-04	3.385	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	4.120930e-04	3.385	0
Platelet activation, signaling and aggregation	R-HSA-76002	4.257758e-04	3.371	0
RAF activation	R-HSA-5673000	4.735031e-04	3.325	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	4.735031e-04	3.325	0
Negative regulation of MET activity	R-HSA-6807004	4.905205e-04	3.309	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	5.021757e-04	3.299	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	5.101982e-04	3.292	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	5.250249e-04	3.280	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	5.263420e-04	3.279	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.640151e-04	3.178	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.640151e-04	3.178	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	6.184044e-04	3.209	0
GP1b-IX-V activation signalling	R-HSA-430116	5.480284e-04	3.261	0
DCC mediated attractive signaling	R-HSA-418885	6.640151e-04	3.178	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	5.480284e-04	3.261	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	6.184044e-04	3.209	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.646280e-04	3.248	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	5.925603e-04	3.227	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	6.781371e-04	3.169	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	7.444134e-04	3.128	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.444134e-04	3.128	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.472973e-04	3.127	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.472973e-04	3.127	0
mRNA Splicing - Major Pathway	R-HSA-72163	7.561434e-04	3.121	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	7.670162e-04	3.115	0
Josephin domain DUBs	R-HSA-5689877	7.825871e-04	3.106	0
Pexophagy	R-HSA-9664873	7.825871e-04	3.106	0
Eukaryotic Translation Termination	R-HSA-72764	8.324536e-04	3.080	0
Negative regulation of FLT3	R-HSA-9706369	8.635618e-04	3.064	0
Chaperonin-mediated protein folding	R-HSA-390466	9.235201e-04	3.035	0
RAF/MAP kinase cascade	R-HSA-5673001	9.416357e-04	3.026	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.451082e-04	3.025	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.644150e-04	3.016	0
Neutrophil degranulation	R-HSA-6798695	9.828291e-04	3.008	0
Maturation of protein E	R-HSA-9683683	1.017479e-03	2.992	0
Maturation of protein E	R-HSA-9694493	1.017479e-03	2.992	0
DNA Repair	R-HSA-73894	1.041151e-03	2.982	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	1.054831e-03	2.977	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.058244e-03	2.975	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.058244e-03	2.975	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.084931e-03	2.965	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.084931e-03	2.965	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.106389e-03	2.956	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	1.221521e-03	2.913	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	1.221521e-03	2.913	0
Signaling by FGFR2	R-HSA-5654738	1.236019e-03	2.908	0
Gene expression (Transcription)	R-HSA-74160	1.272033e-03	2.896	0
Gap junction trafficking and regulation	R-HSA-157858	1.280453e-03	2.893	0
Hedgehog 'off' state	R-HSA-5610787	1.303947e-03	2.885	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.341568e-03	2.872	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	1.348046e-03	2.870	0
Hh mutants are degraded by ERAD	R-HSA-5362768	1.408842e-03	2.851	0
FLT3 Signaling	R-HSA-9607240	1.408842e-03	2.851	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.408842e-03	2.851	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.466193e-03	2.834	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.466193e-03	2.834	0
mRNA Splicing	R-HSA-72172	1.468735e-03	2.833	0
Regulation of MECP2 expression and activity	R-HSA-9022692	1.469780e-03	2.833	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.469780e-03	2.833	0
Clathrin-mediated endocytosis	R-HSA-8856828	1.538533e-03	2.813	0
Viral Messenger RNA Synthesis	R-HSA-168325	1.591260e-03	2.798	0
rRNA processing	R-HSA-72312	1.603860e-03	2.795	0
Protein folding	R-HSA-391251	1.615027e-03	2.792	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.618603e-03	2.791	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.618603e-03	2.791	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.618603e-03	2.791	0
Striated Muscle Contraction	R-HSA-390522	1.718385e-03	2.765	0
Vpu mediated degradation of CD4	R-HSA-180534	1.718385e-03	2.765	0
Ephrin signaling	R-HSA-3928664	1.745751e-03	2.758	0
tRNA processing in the nucleus	R-HSA-6784531	1.777671e-03	2.750	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	1.937917e-03	2.713	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	1.937917e-03	2.713	0
Signaling by PTK6	R-HSA-8848021	1.981513e-03	2.703	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.981513e-03	2.703	0
Mitophagy	R-HSA-5205647	1.999088e-03	2.699	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.999088e-03	2.699	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.999088e-03	2.699	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.999088e-03	2.699	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	1.999088e-03	2.699	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.282923e-03	2.642	0
Formation of a pool of free 40S subunits	R-HSA-72689	2.281900e-03	2.642	0
PTEN Regulation	R-HSA-6807070	2.552717e-03	2.593	0
EPHB-mediated forward signaling	R-HSA-3928662	2.401818e-03	2.619	0
Translesion Synthesis by POLH	R-HSA-110320	2.154901e-03	2.667	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	2.632492e-03	2.580	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	2.314684e-03	2.636	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	2.314684e-03	2.636	0
Gap junction trafficking	R-HSA-190828	2.401818e-03	2.619	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.375913e-03	2.624	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	2.113083e-03	2.675	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	2.668071e-03	2.574	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	2.004816e-03	2.698	0
Signaling by FGFR4	R-HSA-5654743	2.113083e-03	2.675	0
FLT3 signaling in disease	R-HSA-9682385	2.668071e-03	2.574	0
Uptake and function of diphtheria toxin	R-HSA-5336415	2.282923e-03	2.642	0
Regulation of Apoptosis	R-HSA-169911	2.314684e-03	2.636	0
Smooth Muscle Contraction	R-HSA-445355	2.089197e-03	2.680	0
Nephrin family interactions	R-HSA-373753	2.632492e-03	2.580	0
Asymmetric localization of PCP proteins	R-HSA-4608870	2.721021e-03	2.565	0
Signaling by FGFR3	R-HSA-5654741	2.721021e-03	2.565	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	2.721021e-03	2.565	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	2.721021e-03	2.565	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	2.797773e-03	2.553	0
Ovarian tumor domain proteases	R-HSA-5689896	3.062241e-03	2.514	0
Degradation of DVL	R-HSA-4641258	3.062241e-03	2.514	0
Degradation of AXIN	R-HSA-4641257	3.062241e-03	2.514	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	3.062241e-03	2.514	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	3.185347e-03	2.497	0
NRIF signals cell death from the nucleus	R-HSA-205043	3.200231e-03	2.495	0
Signaling by MRAS-complex mutants	R-HSA-9660537	3.204633e-03	2.494	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.204633e-03	2.494	0
Modulation by Mtb of host immune system	R-HSA-9637628	3.204633e-03	2.494	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	3.274782e-03	2.485	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	3.459657e-03	2.461	0
Signaling by MET	R-HSA-6806834	3.540056e-03	2.451	0
Selenocysteine synthesis	R-HSA-2408557	3.695378e-03	2.432	0
Downregulation of ERBB2 signaling	R-HSA-8863795	3.811436e-03	2.419	0
Activation of BH3-only proteins	R-HSA-114452	3.811436e-03	2.419	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	3.820426e-03	2.418	0
Stabilization of p53	R-HSA-69541	3.985346e-03	2.400	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	4.014863e-03	2.396	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	4.014863e-03	2.396	0
Translesion synthesis by REV1	R-HSA-110312	4.014863e-03	2.396	0
Protein methylation	R-HSA-8876725	4.014863e-03	2.396	0
Viral mRNA Translation	R-HSA-192823	4.300676e-03	2.366	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.420840e-03	2.354	0
Signaling by ERBB2	R-HSA-1227986	4.455039e-03	2.351	0
mTORC1-mediated signalling	R-HSA-166208	4.544780e-03	2.342	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	4.632145e-03	2.334	0
Translesion synthesis by POLI	R-HSA-5656121	4.967809e-03	2.304	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	4.989332e-03	2.302	0
PKMTs methylate histone lysines	R-HSA-3214841	5.109572e-03	2.292	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	5.109572e-03	2.292	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.259062e-03	2.279	0
Intracellular signaling by second messengers	R-HSA-9006925	5.281871e-03	2.277	0
Activation of NF-kappaB in B cells	R-HSA-1169091	5.403156e-03	2.267	0
Hedgehog ligand biogenesis	R-HSA-5358346	5.403156e-03	2.267	0
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	5.404468e-03	2.267	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	5.724029e-03	2.242	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.748062e-03	2.240	0
Folding of actin by CCT/TriC	R-HSA-390450	5.748062e-03	2.240	0
Degradation of CRY and PER proteins	R-HSA-9932298	5.755379e-03	2.240	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	5.825520e-03	2.235	0
Regulation of necroptotic cell death	R-HSA-5675482	5.825520e-03	2.235	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	5.873123e-03	2.231	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	5.960511e-03	2.225	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	5.960511e-03	2.225	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	6.000392e-03	2.222	0
Translesion synthesis by POLK	R-HSA-5655862	6.070888e-03	2.217	0
Deadenylation of mRNA	R-HSA-429947	6.289746e-03	2.201	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.289746e-03	2.201	0
Adaptive Immune System	R-HSA-1280218	6.338322e-03	2.198	0
Transcriptional Regulation by TP53	R-HSA-3700989	6.423936e-03	2.192	0
MTOR signalling	R-HSA-165159	6.461494e-03	2.190	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.612947e-03	2.180	0
Regulation of PTEN stability and activity	R-HSA-8948751	6.647228e-03	2.177	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	6.647228e-03	2.177	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	6.647302e-03	2.177	0
Vesicle-mediated transport	R-HSA-5653656	6.729401e-03	2.172	0
Response of Mtb to phagocytosis	R-HSA-9637690	7.231342e-03	2.141	0
Signaling by FGFR	R-HSA-190236	7.304610e-03	2.136	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	7.335654e-03	2.135	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	7.335654e-03	2.135	0
Glycogen storage diseases	R-HSA-3229121	7.335654e-03	2.135	0
Signaling by NOTCH2	R-HSA-1980145	7.552233e-03	2.122	0
Gap junction assembly	R-HSA-190861	7.552233e-03	2.122	0
TCR signaling	R-HSA-202403	7.573451e-03	2.121	0
AURKA Activation by TPX2	R-HSA-8854518	7.835594e-03	2.106	0
Disease	R-HSA-1643685	7.881359e-03	2.103	0
ER-Phagosome pathway	R-HSA-1236974	8.010621e-03	2.096	0
PCP/CE pathway	R-HSA-4086400	8.029519e-03	2.095	0
Netrin-1 signaling	R-HSA-373752	8.068375e-03	2.093	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.068375e-03	2.093	0
PIP3 activates AKT signaling	R-HSA-1257604	8.097992e-03	2.092	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.100076e-03	2.092	0
Signaling by NOTCH3	R-HSA-9012852	8.100076e-03	2.092	0
Cellular response to starvation	R-HSA-9711097	8.458834e-03	2.073	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	8.476975e-03	2.072	0
GAB1 signalosome	R-HSA-180292	8.773311e-03	2.057	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	8.773311e-03	2.057	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.911332e-03	2.050	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.911332e-03	2.050	0
Signaling by FGFR1	R-HSA-5654736	8.911332e-03	2.050	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	8.911332e-03	2.050	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.976053e-03	2.047	0
Transcriptional Regulation by MECP2	R-HSA-8986944	9.285956e-03	2.032	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	9.318090e-03	2.031	0
NF-kB is activated and signals survival	R-HSA-209560	9.371306e-03	2.028	0
Manipulation of host energy metabolism	R-HSA-9636667	1.173651e-02	1.930	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	9.682662e-03	2.014	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.325450e-02	1.878	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.163628e-02	1.934	0
Regulation of signaling by CBL	R-HSA-912631	1.039462e-02	1.983	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	1.039462e-02	1.983	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.039462e-02	1.983	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	1.422870e-02	1.847	0
EPHA-mediated growth cone collapse	R-HSA-3928663	9.753902e-03	2.011	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.957840e-03	2.002	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.957840e-03	2.002	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.395953e-02	1.855	0
Nucleotide Excision Repair	R-HSA-5696398	1.253695e-02	1.902	0
Regulation of IFNG signaling	R-HSA-877312	1.163628e-02	1.934	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	1.422548e-02	1.847	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.183557e-02	1.927	0
Breakdown of the nuclear lamina	R-HSA-352238	1.173651e-02	1.930	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.101719e-02	1.958	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.163628e-02	1.934	0
Glycogen synthesis	R-HSA-3322077	1.220986e-02	1.913	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	1.013530e-02	1.994	0
Platelet degranulation	R-HSA-114608	1.176482e-02	1.929	0
Interleukin-6 signaling	R-HSA-1059683	1.422548e-02	1.847	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.081352e-02	1.966	0
Beta-catenin independent WNT signaling	R-HSA-3858494	1.036013e-02	1.985	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.209847e-02	1.917	0
Signaling by Hedgehog	R-HSA-5358351	1.158238e-02	1.936	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	1.422870e-02	1.847	0
Hedgehog 'on' state	R-HSA-5632684	1.193213e-02	1.923	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.392161e-02	1.856	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	1.113283e-02	1.953	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.193213e-02	1.923	0
VLDLR internalisation and degradation	R-HSA-8866427	1.163628e-02	1.934	0
Selenoamino acid metabolism	R-HSA-2408522	1.156263e-02	1.937	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.338228e-02	1.873	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.338228e-02	1.873	0
p75NTR recruits signalling complexes	R-HSA-209543	1.163628e-02	1.934	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.499267e-02	1.824	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.502576e-02	1.823	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	1.513289e-02	1.820	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	1.609836e-02	1.793	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.623421e-02	1.790	0
Centrosome maturation	R-HSA-380287	1.623421e-02	1.790	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.623421e-02	1.790	0
Budding and maturation of HIV virion	R-HSA-162588	1.623921e-02	1.789	0
Downstream signal transduction	R-HSA-186763	1.623921e-02	1.789	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	1.641999e-02	1.785	0
Semaphorin interactions	R-HSA-373755	1.641999e-02	1.785	0
G1/S DNA Damage Checkpoints	R-HSA-69615	1.641999e-02	1.785	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.646021e-02	1.784	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.646021e-02	1.784	0
Assembly Of The HIV Virion	R-HSA-175474	1.646021e-02	1.784	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.646021e-02	1.784	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.661078e-02	1.780	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	1.696868e-02	1.770	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.715285e-02	1.766	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.715285e-02	1.766	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.731990e-02	1.761	0
Cohesin Loading onto Chromatin	R-HSA-2470946	1.748224e-02	1.757	0
Orc1 removal from chromatin	R-HSA-68949	1.759625e-02	1.755	0
Metabolism of proteins	R-HSA-392499	1.791399e-02	1.747	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.823616e-02	1.739	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.891278e-02	1.723	0
Inositol phosphate metabolism	R-HSA-1483249	1.915036e-02	1.718	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.919163e-02	1.717	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.014146e-02	1.696	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.014146e-02	1.696	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.014146e-02	1.696	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.014146e-02	1.696	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.014146e-02	1.696	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.014146e-02	1.696	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.014146e-02	1.696	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.014146e-02	1.696	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.014146e-02	1.696	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.014146e-02	1.696	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.014146e-02	1.696	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	2.014146e-02	1.696	0
ABC transporter disorders	R-HSA-5619084	2.014591e-02	1.696	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.021017e-02	1.694	0
p75NTR signals via NF-kB	R-HSA-193639	2.043026e-02	1.690	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.053365e-02	1.688	0
Downstream TCR signaling	R-HSA-202424	2.053365e-02	1.688	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	2.088760e-02	1.680	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	2.088760e-02	1.680	0
Cilium Assembly	R-HSA-5617833	2.113301e-02	1.675	0
Sensory processing of sound	R-HSA-9659379	2.159110e-02	1.666	0
Signaling by VEGF	R-HSA-194138	2.204408e-02	1.657	0
Developmental Cell Lineages	R-HSA-9734767	2.205217e-02	1.657	0
Signaling by SCF-KIT	R-HSA-1433557	2.219949e-02	1.654	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	2.219949e-02	1.654	0
Formation of annular gap junctions	R-HSA-196025	2.237621e-02	1.650	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	2.268716e-02	1.644	0
Regulation of NF-kappa B signaling	R-HSA-9758274	2.406752e-02	1.619	0
Regulation of BACH1 activity	R-HSA-9708530	2.406752e-02	1.619	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	2.459320e-02	1.609	0
Dual Incision in GG-NER	R-HSA-5696400	2.521853e-02	1.598	0
Interferon alpha/beta signaling	R-HSA-909733	2.527953e-02	1.597	0
Long-term potentiation	R-HSA-9620244	2.766975e-02	1.558	0
Sema4D in semaphorin signaling	R-HSA-400685	2.766975e-02	1.558	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.775974e-02	1.557	0
Cyclin E associated events during G1/S transition	R-HSA-69202	2.775974e-02	1.557	0
Lipophagy	R-HSA-9613354	2.793925e-02	1.554	0
Gap junction degradation	R-HSA-190873	2.793925e-02	1.554	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	2.793925e-02	1.554	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	2.793925e-02	1.554	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.793925e-02	1.554	0
Disorders of Developmental Biology	R-HSA-9675151	2.807239e-02	1.552	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	2.807239e-02	1.552	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	2.807239e-02	1.552	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	2.897048e-02	1.538	0
Muscle contraction	R-HSA-397014	2.971400e-02	1.527	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.974054e-02	1.527	0
Regulation of mitotic cell cycle	R-HSA-453276	2.974054e-02	1.527	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	3.038479e-02	1.517	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	3.038479e-02	1.517	0
Regulation of TP53 Degradation	R-HSA-6804757	3.074778e-02	1.512	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.181802e-02	1.497	0
Antigen processing-Cross presentation	R-HSA-1236975	3.230342e-02	1.491	0
Regulation of FZD by ubiquitination	R-HSA-4641263	3.245064e-02	1.489	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.333638e-02	1.477	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.333638e-02	1.477	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.333638e-02	1.477	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.333638e-02	1.477	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.333638e-02	1.477	0
Kinesins	R-HSA-983189	3.333638e-02	1.477	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.416763e-02	1.466	0
Gluconeogenesis	R-HSA-70263	3.418686e-02	1.466	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.441138e-02	1.463	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.473321e-02	1.459	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.516911e-02	1.454	0
Transcriptional regulation by RUNX3	R-HSA-8878159	3.516911e-02	1.454	0
Signaling by ERBB4	R-HSA-1236394	3.627076e-02	1.440	0
DNA Damage Bypass	R-HSA-73893	3.701459e-02	1.432	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.720607e-02	1.429	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.720607e-02	1.429	0
p75 NTR receptor-mediated signalling	R-HSA-193704	3.922228e-02	1.406	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.043233e-02	1.393	0
Plasma lipoprotein clearance	R-HSA-8964043	4.043233e-02	1.393	0
Post-translational protein modification	R-HSA-597592	4.078044e-02	1.390	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	4.092625e-02	1.388	0
Signaling by NOTCH1	R-HSA-1980143	4.113248e-02	1.386	0
ABC-family proteins mediated transport	R-HSA-382556	4.136606e-02	1.383	0
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	4.225086e-02	1.374	0
Regulation of gap junction activity	R-HSA-191650	4.225086e-02	1.374	0
Termination of translesion DNA synthesis	R-HSA-5656169	4.281762e-02	1.368	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	4.281762e-02	1.368	0
Interleukin-1 signaling	R-HSA-9020702	4.358953e-02	1.361	0
Glycogen metabolism	R-HSA-8982491	4.404357e-02	1.356	0
mRNA 3'-end processing	R-HSA-72187	4.640497e-02	1.333	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	4.641608e-02	1.333	0
Cellular response to hypoxia	R-HSA-1234174	4.695874e-02	1.328	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	4.785021e-02	1.320	0
Signal transduction by L1	R-HSA-445144	4.785451e-02	1.320	0
Activation of RAC1	R-HSA-428540	4.857823e-02	1.314	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.857823e-02	1.314	0
Death Receptor Signaling	R-HSA-73887	4.998156e-02	1.301	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	5.074340e-02	1.295	0
RNA Polymerase II Transcription	R-HSA-73857	5.117089e-02	1.291	0
Evasion by RSV of host interferon responses	R-HSA-9833109	5.194320e-02	1.284	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.374615e-02	1.270	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	5.374615e-02	1.270	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	5.374615e-02	1.270	0
Defective F9 activation	R-HSA-9673221	5.554156e-02	1.255	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	5.554156e-02	1.255	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.554156e-02	1.255	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	5.598784e-02	1.252	0
C-type lectin receptors (CLRs)	R-HSA-5621481	5.654283e-02	1.248	0
Regulated Necrosis	R-HSA-5218859	5.665787e-02	1.247	0
Pervasive developmental disorders	R-HSA-9005895	5.672809e-02	1.246	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.672809e-02	1.246	0
Disorders of Nervous System Development	R-HSA-9697154	5.672809e-02	1.246	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	5.672809e-02	1.246	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	5.672809e-02	1.246	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.672809e-02	1.246	0
Hereditary fructose intolerance	R-HSA-5657560	1.022043e-01	0.991	0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	1.022043e-01	0.991	0
TICAM1 deficiency - HSE	R-HSA-5602566	1.022043e-01	0.991	0
SARS-CoV-1 targets PDZ proteins in cell-cell junction	R-HSA-9692912	1.022043e-01	0.991	0
MECP2 regulates transcription factors	R-HSA-9022707	1.022175e-01	0.990	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.022175e-01	0.990	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	7.480933e-02	1.126	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.509195e-02	1.022	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	9.509195e-02	1.022	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	6.001243e-02	1.222	0
FGFR2 alternative splicing	R-HSA-6803529	6.664873e-02	1.176	0
G beta:gamma signalling through CDC42	R-HSA-8964616	1.059867e-01	0.975	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	1.059867e-01	0.975	0
Regulation of PTEN mRNA translation	R-HSA-8943723	7.364904e-02	1.133	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	8.100609e-02	1.091	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	6.759694e-02	1.170	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	9.675542e-02	1.014	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.675542e-02	1.014	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	7.333589e-02	1.135	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	1.051277e-01	0.978	0
Interaction between L1 and Ankyrins	R-HSA-445095	1.051277e-01	0.978	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.051277e-01	0.978	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.051277e-01	0.978	0
HIV elongation arrest and recovery	R-HSA-167287	1.138168e-01	0.944	0
Pausing and recovery of HIV elongation	R-HSA-167290	1.138168e-01	0.944	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	8.005469e-02	1.097	0
Dual incision in TC-NER	R-HSA-6782135	6.941758e-02	1.159	0
Formation of RNA Pol II elongation complex	R-HSA-112382	1.089581e-01	0.963	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.153055e-01	0.938	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	7.333589e-02	1.135	0
Regulation of PTEN gene transcription	R-HSA-8943724	7.836809e-02	1.106	0
p38MAPK events	R-HSA-171007	8.468952e-02	1.072	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	7.933198e-02	1.101	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	6.985799e-02	1.156	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	6.302740e-02	1.200	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	6.664873e-02	1.176	0
Proteasome assembly	R-HSA-9907900	6.505780e-02	1.187	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	9.103885e-02	1.041	0
Deadenylation-dependent mRNA decay	R-HSA-429914	7.381260e-02	1.132	0
FOXO-mediated transcription	R-HSA-9614085	7.844639e-02	1.105	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	7.007504e-02	1.154	0
Intraflagellar transport	R-HSA-5620924	8.544911e-02	1.068	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	7.007504e-02	1.154	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.146866e-01	0.940	0
Inhibition of PKR	R-HSA-169131	1.022043e-01	0.991	0
Netrin mediated repulsion signals	R-HSA-418886	1.022175e-01	0.990	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	6.001243e-02	1.222	0
COPI-mediated anterograde transport	R-HSA-6807878	6.819985e-02	1.166	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.059867e-01	0.975	0
Transcriptional Regulation by E2F6	R-HSA-8953750	1.058179e-01	0.975	0
NOD1/2 Signaling Pathway	R-HSA-168638	7.333589e-02	1.135	0
Signalling to ERKs	R-HSA-187687	7.933198e-02	1.101	0
Extra-nuclear estrogen signaling	R-HSA-9009391	8.577910e-02	1.067	0
Regulation of TNFR1 signaling	R-HSA-5357905	7.485724e-02	1.126	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	8.100609e-02	1.091	0
Neurodegenerative Diseases	R-HSA-8863678	8.100609e-02	1.091	0
Nef and signal transduction	R-HSA-164944	8.568458e-02	1.067	0
Synthesis of PG	R-HSA-1483148	1.059867e-01	0.975	0
Switching of origins to a post-replicative state	R-HSA-69052	7.546630e-02	1.122	0
TNF signaling	R-HSA-75893	6.110911e-02	1.214	0
RAS processing	R-HSA-9648002	1.058179e-01	0.975	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	9.509195e-02	1.022	0
Generic Transcription Pathway	R-HSA-212436	1.116761e-01	0.952	0
Signaling by PDGFR in disease	R-HSA-9671555	6.001243e-02	1.222	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.818344e-02	1.008	0
Circadian clock	R-HSA-9909396	1.093174e-01	0.961	0
Signaling by KIT in disease	R-HSA-9669938	6.664873e-02	1.176	0
ER to Golgi Anterograde Transport	R-HSA-199977	1.155264e-01	0.937	0
Organelle biogenesis and maintenance	R-HSA-1852241	7.739217e-02	1.111	0
S Phase	R-HSA-69242	7.022447e-02	1.154	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	6.211751e-02	1.207	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	1.058179e-01	0.975	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	6.505780e-02	1.187	0
Interleukin-6 family signaling	R-HSA-6783589	8.100609e-02	1.091	0
Signaling by TGFB family members	R-HSA-9006936	1.066026e-01	0.972	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	6.110911e-02	1.214	0
RNA Polymerase II Transcription Termination	R-HSA-73856	8.308367e-02	1.080	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.558219e-02	1.068	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	7.364904e-02	1.133	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	1.051277e-01	0.978	0
Oncogene Induced Senescence	R-HSA-2559585	7.933198e-02	1.101	0
Cellular response to chemical stress	R-HSA-9711123	6.865019e-02	1.163	0
Signal regulatory protein family interactions	R-HSA-391160	7.480933e-02	1.126	0
Regulation of pyruvate metabolism	R-HSA-9861718	7.485724e-02	1.126	0
Formation of paraxial mesoderm	R-HSA-9793380	8.308367e-02	1.080	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	6.754238e-02	1.170	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	1.059867e-01	0.975	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	1.089581e-01	0.963	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.051277e-01	0.978	0
Somitogenesis	R-HSA-9824272	6.985799e-02	1.156	0
Transcriptional regulation by RUNX2	R-HSA-8878166	1.100635e-01	0.958	0
Potential therapeutics for SARS	R-HSA-9679191	7.562485e-02	1.121	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	9.208284e-02	1.036	0
Suppression of phagosomal maturation	R-HSA-9637687	9.675542e-02	1.014	0
Disorders of transmembrane transporters	R-HSA-5619115	9.185978e-02	1.037	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.173427e-01	0.931	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	1.195342e-01	0.923	0
Activated NTRK2 signals through FYN	R-HSA-9032500	1.195342e-01	0.923	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.195342e-01	0.923	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.204964e-01	0.919	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.228107e-01	0.911	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.228107e-01	0.911	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	1.230603e-01	0.910	0
Translation of Structural Proteins	R-HSA-9683701	1.281745e-01	0.892	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.291284e-01	0.889	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.320966e-01	0.879	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	1.338304e-01	0.873	0
Hemostasis	R-HSA-109582	1.350071e-01	0.870	0
Interleukin-1 family signaling	R-HSA-446652	1.352905e-01	0.869	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.360697e-01	0.866	0
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	1.375071e-01	0.862	0
ALK mutants bind TKIs	R-HSA-9700645	1.375071e-01	0.862	0
Calcineurin activates NFAT	R-HSA-2025928	1.375071e-01	0.862	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	1.375071e-01	0.862	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	1.375071e-01	0.862	0
ARMS-mediated activation	R-HSA-170984	1.375071e-01	0.862	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.375071e-01	0.862	0
Cellular response to mitochondrial stress	R-HSA-9840373	1.375071e-01	0.862	0
Respiratory syncytial virus genome replication	R-HSA-9834752	1.375071e-01	0.862	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.402913e-01	0.853	0
G1/S Transition	R-HSA-69206	1.408420e-01	0.851	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	1.413117e-01	0.850	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	1.413117e-01	0.850	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.413117e-01	0.850	0
Rap1 signalling	R-HSA-392517	1.413117e-01	0.850	0
Diseases of hemostasis	R-HSA-9671793	1.413117e-01	0.850	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	1.416611e-01	0.849	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.456789e-01	0.837	0
Interactions of Tat with host cellular proteins	R-HSA-176034	1.493241e-01	0.826	0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	1.493241e-01	0.826	0
TRAF3 deficiency - HSE	R-HSA-5602571	1.493241e-01	0.826	0
PTEN Loss of Function in Cancer	R-HSA-5674404	1.493241e-01	0.826	0
Transport of connexins along the secretory pathway	R-HSA-190827	1.493241e-01	0.826	0
Defective SERPING1 causes hereditary angioedema	R-HSA-9657689	1.493241e-01	0.826	0
Oligomerization of connexins into connexons	R-HSA-190704	1.493241e-01	0.826	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	1.514904e-01	0.820	0
Cyclin D associated events in G1	R-HSA-69231	1.524824e-01	0.817	0
G1 Phase	R-HSA-69236	1.524824e-01	0.817	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	1.538605e-01	0.813	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	1.538605e-01	0.813	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.538605e-01	0.813	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.560198e-01	0.807	0
Regulation of CDH11 function	R-HSA-9762292	1.560198e-01	0.807	0
EGFR Transactivation by Gastrin	R-HSA-2179392	1.560198e-01	0.807	0
MAPK3 (ERK1) activation	R-HSA-110056	1.560198e-01	0.807	0
Receptor Mediated Mitophagy	R-HSA-8934903	1.560198e-01	0.807	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	1.560198e-01	0.807	0
Defective factor IX causes hemophilia B	R-HSA-9668250	1.560198e-01	0.807	0
Integrin signaling	R-HSA-354192	1.615702e-01	0.792	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.615702e-01	0.792	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.615702e-01	0.792	0
Neddylation	R-HSA-8951664	1.622020e-01	0.790	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.667425e-01	0.778	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	1.667425e-01	0.778	0
Signalling to RAS	R-HSA-167044	1.667425e-01	0.778	0
Basigin interactions	R-HSA-210991	1.667425e-01	0.778	0
mRNA Splicing - Minor Pathway	R-HSA-72165	1.696733e-01	0.770	0
RHOBTB3 ATPase cycle	R-HSA-9706019	1.749664e-01	0.757	0
Suppression of apoptosis	R-HSA-9635465	1.749664e-01	0.757	0
PECAM1 interactions	R-HSA-210990	1.749664e-01	0.757	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	1.785403e-01	0.748	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.785403e-01	0.748	0
Signaling by PDGF	R-HSA-186797	1.801114e-01	0.744	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.805613e-01	0.743	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.807228e-01	0.743	0
Signal amplification	R-HSA-392518	1.824231e-01	0.739	0
Calnexin/calreticulin cycle	R-HSA-901042	1.824231e-01	0.739	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.875769e-01	0.727	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.931663e-01	0.714	0
PERK regulates gene expression	R-HSA-381042	1.931663e-01	0.714	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	1.933796e-01	0.714	0
Signaling by RAS GAP mutants	R-HSA-9753510	1.939736e-01	0.712	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	1.939736e-01	0.712	0
Defective AHCY causes HMAHCHD	R-HSA-5578997	1.939736e-01	0.712	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	1.939736e-01	0.712	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	1.939736e-01	0.712	0
Potassium transport channels	R-HSA-1296067	1.939736e-01	0.712	0
Regulation of cortical dendrite branching	R-HSA-8985801	1.939736e-01	0.712	0
Defective factor XII causes hereditary angioedema	R-HSA-9657688	1.939736e-01	0.712	0
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	1.939736e-01	0.712	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	1.942505e-01	0.712	0
Integration of provirus	R-HSA-162592	1.942505e-01	0.712	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	1.942505e-01	0.712	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.942505e-01	0.712	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.942505e-01	0.712	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	1.967745e-01	0.706	0
MITF-M-regulated melanocyte development	R-HSA-9730414	1.973481e-01	0.705	0
Synthesis of DNA	R-HSA-69239	1.976791e-01	0.704	0
Stimuli-sensing channels	R-HSA-2672351	2.040043e-01	0.690	0
GPVI-mediated activation cascade	R-HSA-114604	2.041008e-01	0.690	0
Calmodulin induced events	R-HSA-111933	2.041008e-01	0.690	0
CaM pathway	R-HSA-111997	2.041008e-01	0.690	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	2.070725e-01	0.684	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	2.070725e-01	0.684	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.070725e-01	0.684	0
MHC class II antigen presentation	R-HSA-2132295	2.097813e-01	0.678	0
GRB2 events in EGFR signaling	R-HSA-179812	2.137846e-01	0.670	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	2.137846e-01	0.670	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	2.209745e-01	0.656	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.241515e-01	0.649	0
Uptake and actions of bacterial toxins	R-HSA-5339562	2.252431e-01	0.647	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.334896e-01	0.632	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.334896e-01	0.632	0
Platelet Adhesion to exposed collagen	R-HSA-75892	2.334896e-01	0.632	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	2.334896e-01	0.632	0
Frs2-mediated activation	R-HSA-170968	2.334896e-01	0.632	0
Reversible hydration of carbon dioxide	R-HSA-1475029	2.334896e-01	0.632	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.334896e-01	0.632	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	2.334896e-01	0.632	0
SWI/SNF chromatin remodelers	R-HSA-9932451	2.350565e-01	0.629	0
ATP-dependent chromatin remodelers	R-HSA-9932444	2.350565e-01	0.629	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	2.350565e-01	0.629	0
Tight junction interactions	R-HSA-420029	2.350565e-01	0.629	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	2.350565e-01	0.629	0
HDMs demethylate histones	R-HSA-3214842	2.350565e-01	0.629	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	2.362821e-01	0.627	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.362821e-01	0.627	0
MET activates PTPN11	R-HSA-8865999	2.362821e-01	0.627	0
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	2.362821e-01	0.627	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.362821e-01	0.627	0
FasL/ CD95L signaling	R-HSA-75157	2.362821e-01	0.627	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	2.376690e-01	0.624	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.379002e-01	0.624	0
Cellular responses to mechanical stimuli	R-HSA-9855142	2.435927e-01	0.613	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.472651e-01	0.607	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	2.492901e-01	0.603	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	2.492901e-01	0.603	0
HIV Transcription Elongation	R-HSA-167169	2.494486e-01	0.603	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.494486e-01	0.603	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.494486e-01	0.603	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.526661e-01	0.597	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.532937e-01	0.596	0
Regulation of KIT signaling	R-HSA-1433559	2.532937e-01	0.596	0
Malate-aspartate shuttle	R-HSA-9856872	2.532937e-01	0.596	0
G alpha (z) signalling events	R-HSA-418597	2.548343e-01	0.594	0
Regulation of TP53 Activity	R-HSA-5633007	2.573405e-01	0.589	0
Pyruvate metabolism	R-HSA-70268	2.634066e-01	0.579	0
Cristae formation	R-HSA-8949613	2.636478e-01	0.579	0
RNA Polymerase I Transcription Termination	R-HSA-73863	2.636478e-01	0.579	0
NRAGE signals death through JNK	R-HSA-193648	2.649046e-01	0.577	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	2.731323e-01	0.564	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.731323e-01	0.564	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.731323e-01	0.564	0
SHC1 events in EGFR signaling	R-HSA-180336	2.731323e-01	0.564	0
G beta:gamma signalling through BTK	R-HSA-8964315	2.731323e-01	0.564	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	2.731323e-01	0.564	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	2.731323e-01	0.564	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.731323e-01	0.564	0
Diseases of carbohydrate metabolism	R-HSA-5663084	2.741202e-01	0.562	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.750628e-01	0.561	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	2.763723e-01	0.559	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	2.763723e-01	0.559	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.763723e-01	0.559	0
TNFR1-mediated ceramide production	R-HSA-5626978	2.763723e-01	0.559	0
NADE modulates death signalling	R-HSA-205025	2.763723e-01	0.559	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	2.773275e-01	0.557	0
Golgi-to-ER retrograde transport	R-HSA-8856688	2.800196e-01	0.553	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.832242e-01	0.548	0
Response of endothelial cells to shear stress	R-HSA-9860931	2.834115e-01	0.548	0
Opioid Signalling	R-HSA-111885	2.834115e-01	0.548	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.847341e-01	0.546	0
Ca-dependent events	R-HSA-111996	2.847341e-01	0.546	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.872064e-01	0.542	0
mRNA Capping	R-HSA-72086	2.926313e-01	0.534	0
Prolonged ERK activation events	R-HSA-169893	2.929475e-01	0.533	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	2.929475e-01	0.533	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.072075e-01	0.513	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	3.072075e-01	0.513	0
DAP12 signaling	R-HSA-2424491	3.072075e-01	0.513	0
Transmission across Chemical Synapses	R-HSA-112315	3.078915e-01	0.512	0
Translation of Structural Proteins	R-HSA-9694635	3.109040e-01	0.507	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	3.126870e-01	0.505	0
Passive transport by Aquaporins	R-HSA-432047	3.126870e-01	0.505	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	3.126870e-01	0.505	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	3.134150e-01	0.504	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	3.134150e-01	0.504	0
Integration of energy metabolism	R-HSA-163685	3.140168e-01	0.503	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.143603e-01	0.503	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	3.143603e-01	0.503	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	3.143603e-01	0.503	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	3.143603e-01	0.503	0
Nectin/Necl trans heterodimerization	R-HSA-420597	3.143603e-01	0.503	0
Reelin signalling pathway	R-HSA-8866376	3.143603e-01	0.503	0
NTRK2 activates RAC1	R-HSA-9032759	3.143603e-01	0.503	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	3.143603e-01	0.503	0
Muscarinic acetylcholine receptors	R-HSA-390648	3.143603e-01	0.503	0
Co-inhibition by BTLA	R-HSA-9927353	3.143603e-01	0.503	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	3.143603e-01	0.503	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	3.143603e-01	0.503	0
MAP kinase activation	R-HSA-450294	3.163940e-01	0.500	0
Protein localization	R-HSA-9609507	3.195727e-01	0.495	0
G alpha (12/13) signalling events	R-HSA-416482	3.202322e-01	0.495	0
Fanconi Anemia Pathway	R-HSA-6783310	3.206830e-01	0.494	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	3.206830e-01	0.494	0
DAG and IP3 signaling	R-HSA-1489509	3.206830e-01	0.494	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.223298e-01	0.492	0
tRNA processing	R-HSA-72306	3.241984e-01	0.489	0
NCAM signaling for neurite out-growth	R-HSA-375165	3.268571e-01	0.486	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.302354e-01	0.481	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	3.323043e-01	0.478	0
G0 and Early G1	R-HSA-1538133	3.364136e-01	0.473	0
Inwardly rectifying K+ channels	R-HSA-1296065	3.364136e-01	0.473	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	3.390581e-01	0.470	0
Plus-strand DNA synthesis	R-HSA-164525	3.503563e-01	0.455	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.503563e-01	0.455	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	3.503563e-01	0.455	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	3.503563e-01	0.455	0
Phosphorylation of Emi1	R-HSA-176417	3.503563e-01	0.455	0
Noncanonical activation of NOTCH3	R-HSA-9017802	3.503563e-01	0.455	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	3.503563e-01	0.455	0
Signalling to p38 via RIT and RIN	R-HSA-187706	3.503563e-01	0.455	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.503563e-01	0.455	0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	3.503563e-01	0.455	0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	3.503563e-01	0.455	0
TRAIL signaling	R-HSA-75158	3.503563e-01	0.455	0
G-protein beta:gamma signalling	R-HSA-397795	3.510006e-01	0.455	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.510006e-01	0.455	0
G beta:gamma signalling through PLC beta	R-HSA-418217	3.517579e-01	0.454	0
RNA Polymerase III Transcription Termination	R-HSA-73980	3.517579e-01	0.454	0
Polo-like kinase mediated events	R-HSA-156711	3.517579e-01	0.454	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.517579e-01	0.454	0
Presynaptic function of Kainate receptors	R-HSA-500657	3.517579e-01	0.454	0
Tie2 Signaling	R-HSA-210993	3.517579e-01	0.454	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	3.517579e-01	0.454	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.517579e-01	0.454	0
GPER1 signaling	R-HSA-9634597	3.569351e-01	0.447	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	3.621413e-01	0.441	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	3.655503e-01	0.437	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.710110e-01	0.431	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.710110e-01	0.431	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	3.710110e-01	0.431	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	3.710110e-01	0.431	0
The NLRP3 inflammasome	R-HSA-844456	3.710110e-01	0.431	0
Other interleukin signaling	R-HSA-449836	3.710110e-01	0.431	0
Maturation of nucleoprotein	R-HSA-9694631	3.710110e-01	0.431	0
Regulation of insulin secretion	R-HSA-422356	3.736280e-01	0.428	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.736280e-01	0.428	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.736280e-01	0.428	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.736280e-01	0.428	0
FCERI mediated NF-kB activation	R-HSA-2871837	3.771872e-01	0.423	0
G-protein mediated events	R-HSA-112040	3.795286e-01	0.421	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	3.800442e-01	0.420	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.844645e-01	0.415	0
STAT5 Activation	R-HSA-9645135	3.844645e-01	0.415	0
Autointegration results in viral DNA circles	R-HSA-177539	3.844645e-01	0.415	0
Uncoating of the HIV Virion	R-HSA-162585	3.844645e-01	0.415	0
G2/M DNA replication checkpoint	R-HSA-69478	3.844645e-01	0.415	0
Metabolism of ingested MeSeO2H into MeSeH	R-HSA-5263617	3.844645e-01	0.415	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.844645e-01	0.415	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.844645e-01	0.415	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	3.844645e-01	0.415	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	3.844645e-01	0.415	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.844645e-01	0.415	0
HDL clearance	R-HSA-8964011	3.844645e-01	0.415	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.844645e-01	0.415	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.862669e-01	0.413	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.900310e-01	0.409	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.900310e-01	0.409	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.900310e-01	0.409	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.900310e-01	0.409	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.900310e-01	0.409	0
Co-inhibition by CTLA4	R-HSA-389513	3.900310e-01	0.409	0
Creatine metabolism	R-HSA-71288	3.900310e-01	0.409	0
Transcription of the HIV genome	R-HSA-167172	3.900780e-01	0.409	0
Signaling by NTRKs	R-HSA-166520	4.056905e-01	0.392	0
Early Phase of HIV Life Cycle	R-HSA-162594	4.087894e-01	0.389	0
G-protein activation	R-HSA-202040	4.087894e-01	0.389	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	4.087959e-01	0.388	0
RNA Polymerase III Transcription	R-HSA-74158	4.087959e-01	0.388	0
G1/S-Specific Transcription	R-HSA-69205	4.087959e-01	0.388	0
RET signaling	R-HSA-8853659	4.087959e-01	0.388	0
Interleukin-17 signaling	R-HSA-448424	4.111312e-01	0.386	0
Transport to the Golgi and subsequent modification	R-HSA-948021	4.139647e-01	0.383	0
TRIF-mediated programmed cell death	R-HSA-2562578	4.167839e-01	0.380	0
IFNG signaling activates MAPKs	R-HSA-9732724	4.167839e-01	0.380	0
Recycling of eIF2:GDP	R-HSA-72731	4.167839e-01	0.380	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.167839e-01	0.380	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	4.167839e-01	0.380	0
SOS-mediated signalling	R-HSA-112412	4.167839e-01	0.380	0
VLDL clearance	R-HSA-8964046	4.167839e-01	0.380	0
CHL1 interactions	R-HSA-447041	4.167839e-01	0.380	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	4.167839e-01	0.380	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.171485e-01	0.380	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.201710e-01	0.377	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	4.265691e-01	0.370	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	4.265691e-01	0.370	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	4.272612e-01	0.369	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	4.272612e-01	0.369	0
Mitochondrial calcium ion transport	R-HSA-8949215	4.272612e-01	0.369	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	4.272612e-01	0.369	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	4.320766e-01	0.364	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	4.342378e-01	0.362	0
RSV-host interactions	R-HSA-9833110	4.343695e-01	0.362	0
MET promotes cell motility	R-HSA-8875878	4.371292e-01	0.359	0
Ca2+ pathway	R-HSA-4086398	4.424922e-01	0.354	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	4.426443e-01	0.354	0
Notch-HLH transcription pathway	R-HSA-350054	4.454249e-01	0.351	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	4.454249e-01	0.351	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	4.454249e-01	0.351	0
Fructose metabolism	R-HSA-5652084	4.454249e-01	0.351	0
RAF-independent MAPK1/3 activation	R-HSA-112409	4.454249e-01	0.351	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.454249e-01	0.351	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	4.454249e-01	0.351	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	4.454249e-01	0.351	0
Reverse Transcription of HIV RNA	R-HSA-162589	4.474081e-01	0.349	0
Minus-strand DNA synthesis	R-HSA-164516	4.474081e-01	0.349	0
Type I hemidesmosome assembly	R-HSA-446107	4.474081e-01	0.349	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	4.474081e-01	0.349	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	4.474081e-01	0.349	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	4.474081e-01	0.349	0
Activation of RAS in B cells	R-HSA-1169092	4.474081e-01	0.349	0
Fructose biosynthesis	R-HSA-5652227	4.474081e-01	0.349	0
Interleukin-9 signaling	R-HSA-8985947	4.474081e-01	0.349	0
TGFBR3 PTM regulation	R-HSA-9839383	4.474081e-01	0.349	0
Alpha-defensins	R-HSA-1462054	4.474081e-01	0.349	0
Adrenoceptors	R-HSA-390696	4.474081e-01	0.349	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.506593e-01	0.346	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.506593e-01	0.346	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.511040e-01	0.346	0
Pentose phosphate pathway	R-HSA-71336	4.511040e-01	0.346	0
Signaling by ALK	R-HSA-201556	4.511040e-01	0.346	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	4.511040e-01	0.346	0
Signaling by FGFR in disease	R-HSA-1226099	4.528612e-01	0.344	0
Iron uptake and transport	R-HSA-917937	4.631777e-01	0.334	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	4.632620e-01	0.334	0
Interleukin-20 family signaling	R-HSA-8854691	4.632620e-01	0.334	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.632620e-01	0.334	0
Unfolded Protein Response (UPR)	R-HSA-381119	4.646065e-01	0.333	0
Generation of second messenger molecules	R-HSA-202433	4.649345e-01	0.333	0
Nuclear signaling by ERBB4	R-HSA-1251985	4.649345e-01	0.333	0
Leishmania phagocytosis	R-HSA-9664417	4.720823e-01	0.326	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	4.720823e-01	0.326	0
Parasite infection	R-HSA-9664407	4.720823e-01	0.326	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	4.764261e-01	0.322	0
Interleukin-21 signaling	R-HSA-9020958	4.764261e-01	0.322	0
MAPK1 (ERK2) activation	R-HSA-112411	4.764261e-01	0.322	0
Regulation of CDH11 gene transcription	R-HSA-9762293	4.764261e-01	0.322	0
Inactivation of CDC42 and RAC1	R-HSA-428543	4.764261e-01	0.322	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	4.764261e-01	0.322	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	4.764261e-01	0.322	0
Regulated proteolysis of p75NTR	R-HSA-193692	4.764261e-01	0.322	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	4.764261e-01	0.322	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	4.764261e-01	0.322	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.786093e-01	0.320	0
Thromboxane signalling through TP receptor	R-HSA-428930	4.807566e-01	0.318	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	4.807566e-01	0.318	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.807566e-01	0.318	0
Interferon gamma signaling	R-HSA-877300	4.838637e-01	0.315	0
MyD88-independent TLR4 cascade	R-HSA-166166	4.857773e-01	0.314	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	4.857773e-01	0.314	0
Peroxisomal protein import	R-HSA-9033241	4.874955e-01	0.312	0
Intra-Golgi traffic	R-HSA-6811438	4.921182e-01	0.308	0
Signaling by FGFR1 in disease	R-HSA-5655302	4.921182e-01	0.308	0
G protein gated Potassium channels	R-HSA-1296059	4.978956e-01	0.303	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	4.978956e-01	0.303	0
Activation of G protein gated Potassium channels	R-HSA-1296041	4.978956e-01	0.303	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.978956e-01	0.303	0
TGFBR3 expression	R-HSA-9839394	4.978956e-01	0.303	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	4.978956e-01	0.303	0
Acyl chain remodelling of PS	R-HSA-1482801	4.978956e-01	0.303	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	4.978956e-01	0.303	0
RAB geranylgeranylation	R-HSA-8873719	4.988983e-01	0.302	0
Metabolism of polyamines	R-HSA-351202	4.988983e-01	0.302	0
Binding and entry of HIV virion	R-HSA-173107	5.039219e-01	0.298	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	5.039219e-01	0.298	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	5.039219e-01	0.298	0
Formation of intermediate mesoderm	R-HSA-9761174	5.039219e-01	0.298	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	5.039219e-01	0.298	0
2-LTR circle formation	R-HSA-164843	5.039219e-01	0.298	0
Interleukin-27 signaling	R-HSA-9020956	5.039219e-01	0.298	0
MET activates RAP1 and RAC1	R-HSA-8875555	5.039219e-01	0.298	0
Apoptosis induced DNA fragmentation	R-HSA-140342	5.039219e-01	0.298	0
Signaling by Leptin	R-HSA-2586552	5.039219e-01	0.298	0
Activation of GABAB receptors	R-HSA-991365	5.054518e-01	0.296	0
GABA B receptor activation	R-HSA-977444	5.054518e-01	0.296	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	5.054518e-01	0.296	0
Aquaporin-mediated transport	R-HSA-445717	5.101903e-01	0.292	0
PLC beta mediated events	R-HSA-112043	5.101903e-01	0.292	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	5.102018e-01	0.292	0
MET activates PTK2 signaling	R-HSA-8874081	5.146681e-01	0.288	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.146681e-01	0.288	0
Myogenesis	R-HSA-525793	5.146681e-01	0.288	0
Mitochondrial protein import	R-HSA-1268020	5.213654e-01	0.283	0
Heme signaling	R-HSA-9707616	5.213654e-01	0.283	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	5.299754e-01	0.276	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	5.299754e-01	0.276	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	5.299754e-01	0.276	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	5.299754e-01	0.276	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	5.299754e-01	0.276	0
Signaling by APC mutants	R-HSA-4839744	5.299754e-01	0.276	0
vRNP Assembly	R-HSA-192905	5.299754e-01	0.276	0
Bicarbonate transporters	R-HSA-425381	5.299754e-01	0.276	0
Activated NTRK3 signals through RAS	R-HSA-9034864	5.299754e-01	0.276	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	5.299754e-01	0.276	0
LGI-ADAM interactions	R-HSA-5682910	5.299754e-01	0.276	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	5.299754e-01	0.276	0
Dissolution of Fibrin Clot	R-HSA-75205	5.299754e-01	0.276	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	5.310653e-01	0.275	0
Insulin processing	R-HSA-264876	5.310653e-01	0.275	0
DAP12 interactions	R-HSA-2172127	5.315600e-01	0.274	0
Post-translational protein phosphorylation	R-HSA-8957275	5.345964e-01	0.272	0
SLC transporter disorders	R-HSA-5619102	5.392743e-01	0.268	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	5.443199e-01	0.264	0
Gastrulation	R-HSA-9758941	5.452730e-01	0.263	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.470803e-01	0.262	0
Formation of the Early Elongation Complex	R-HSA-113418	5.470803e-01	0.262	0
Phase 0 - rapid depolarisation	R-HSA-5576892	5.470803e-01	0.262	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.470803e-01	0.262	0
Inflammasomes	R-HSA-622312	5.470803e-01	0.262	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	5.470803e-01	0.262	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	5.470803e-01	0.262	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	5.546620e-01	0.256	0
Signaling by GSK3beta mutants	R-HSA-5339716	5.546620e-01	0.256	0
Signaling by AMER1 mutants	R-HSA-4839748	5.546620e-01	0.256	0
Signaling by AXIN mutants	R-HSA-4839735	5.546620e-01	0.256	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.546620e-01	0.256	0
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	5.546620e-01	0.256	0
Activated NTRK2 signals through RAS	R-HSA-9026519	5.546620e-01	0.256	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.546620e-01	0.256	0
Innate Immune System	R-HSA-168249	5.551791e-01	0.256	0
Signaling by TGFBR3	R-HSA-9839373	5.568754e-01	0.254	0
Rab regulation of trafficking	R-HSA-9007101	5.600216e-01	0.252	0
Downstream signaling of activated FGFR3	R-HSA-5654708	5.627082e-01	0.250	0
Signaling by Erythropoietin	R-HSA-9006335	5.627082e-01	0.250	0
Glucagon-type ligand receptors	R-HSA-420092	5.627082e-01	0.250	0
Ion channel transport	R-HSA-983712	5.660631e-01	0.247	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	5.717035e-01	0.243	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	5.779453e-01	0.238	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	5.779453e-01	0.238	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	5.779453e-01	0.238	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	5.779453e-01	0.238	0
Downstream signaling of activated FGFR4	R-HSA-5654716	5.779453e-01	0.238	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	5.779453e-01	0.238	0
Interleukin-37 signaling	R-HSA-9008059	5.779453e-01	0.238	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.780535e-01	0.238	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	5.780535e-01	0.238	0
Scavenging by Class F Receptors	R-HSA-3000484	5.780535e-01	0.238	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	5.780535e-01	0.238	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	5.780535e-01	0.238	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	5.780535e-01	0.238	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	5.780535e-01	0.238	0
Leading Strand Synthesis	R-HSA-69109	5.780535e-01	0.238	0
Polymerase switching	R-HSA-69091	5.780535e-01	0.238	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.780535e-01	0.238	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.780535e-01	0.238	0
Interleukin-35 Signalling	R-HSA-8984722	5.780535e-01	0.238	0
MET activates RAS signaling	R-HSA-8851805	5.780535e-01	0.238	0
SHC-related events triggered by IGF1R	R-HSA-2428933	5.780535e-01	0.238	0
Estrogen biosynthesis	R-HSA-193144	5.780535e-01	0.238	0
OAS antiviral response	R-HSA-8983711	5.780535e-01	0.238	0
Toll-like Receptor Cascades	R-HSA-168898	5.786687e-01	0.238	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.810061e-01	0.236	0
Co-stimulation by CD28	R-HSA-389356	5.813521e-01	0.236	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	5.927897e-01	0.227	0
Trafficking of AMPA receptors	R-HSA-399719	5.927897e-01	0.227	0
Processing of SMDT1	R-HSA-8949664	6.002177e-01	0.222	0
Formation of axial mesoderm	R-HSA-9796292	6.002177e-01	0.222	0
CD28 dependent Vav1 pathway	R-HSA-389359	6.002177e-01	0.222	0
Maturation of nucleoprotein	R-HSA-9683610	6.002177e-01	0.222	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	6.029605e-01	0.220	0
Signaling by FGFR2 in disease	R-HSA-5655253	6.049548e-01	0.218	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.212188e-01	0.207	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.212188e-01	0.207	0
Prolactin receptor signaling	R-HSA-1170546	6.212188e-01	0.207	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	6.212188e-01	0.207	0
Zinc transporters	R-HSA-435354	6.212188e-01	0.207	0
Signaling by FGFR4 in disease	R-HSA-5655291	6.212188e-01	0.207	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	6.212981e-01	0.207	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	6.212981e-01	0.207	0
FGFR1 mutant receptor activation	R-HSA-1839124	6.212981e-01	0.207	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	6.212981e-01	0.207	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	6.212981e-01	0.207	0
Neurexins and neuroligins	R-HSA-6794361	6.276585e-01	0.202	0
Neuronal System	R-HSA-112316	6.332319e-01	0.198	0
IRE1alpha activates chaperones	R-HSA-381070	6.344407e-01	0.198	0
Resolution of D-Loop Structures	R-HSA-5693537	6.349640e-01	0.197	0
Effects of PIP2 hydrolysis	R-HSA-114508	6.349640e-01	0.197	0
Glucagon signaling in metabolic regulation	R-HSA-163359	6.349640e-01	0.197	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	6.411180e-01	0.193	0
Beta-catenin phosphorylation cascade	R-HSA-196299	6.411180e-01	0.193	0
RNA Polymerase III Chain Elongation	R-HSA-73780	6.411180e-01	0.193	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	6.411180e-01	0.193	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	6.411180e-01	0.193	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	6.411180e-01	0.193	0
Erythropoietin activates RAS	R-HSA-9027284	6.411180e-01	0.193	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.482404e-01	0.188	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.482404e-01	0.188	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	6.506927e-01	0.187	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	6.512933e-01	0.186	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	6.539379e-01	0.184	0
Parasitic Infection Pathways	R-HSA-9824443	6.549818e-01	0.184	0
Leishmania infection	R-HSA-9658195	6.549818e-01	0.184	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	6.595322e-01	0.181	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.598699e-01	0.181	0
Defective GALNT3 causes HFTC	R-HSA-5083625	6.599729e-01	0.180	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	6.599729e-01	0.180	0
Activation of SMO	R-HSA-5635838	6.599729e-01	0.180	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.599729e-01	0.180	0
Phosphorylation of the APC/C	R-HSA-176412	6.599729e-01	0.180	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.599729e-01	0.180	0
Killing mechanisms	R-HSA-9664420	6.599729e-01	0.180	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.599729e-01	0.180	0
Induction of Cell-Cell Fusion	R-HSA-9733458	6.599729e-01	0.180	0
Fructose catabolism	R-HSA-70350	6.599729e-01	0.180	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.599729e-01	0.180	0
Differentiation of T cells	R-HSA-9945266	6.599729e-01	0.180	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.599729e-01	0.180	0
Attachment and Entry	R-HSA-9678110	6.599729e-01	0.180	0
Downstream signaling of activated FGFR2	R-HSA-5654696	6.611306e-01	0.180	0
Downstream signaling of activated FGFR1	R-HSA-5654687	6.611306e-01	0.180	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.646807e-01	0.177	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	6.703118e-01	0.174	0
Ion homeostasis	R-HSA-5578775	6.703118e-01	0.174	0
FGFR2 mutant receptor activation	R-HSA-1839126	6.736386e-01	0.172	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.778383e-01	0.169	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.778383e-01	0.169	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	6.778383e-01	0.169	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	6.778383e-01	0.169	0
Galactose catabolism	R-HSA-70370	6.778383e-01	0.169	0
Acetylcholine regulates insulin secretion	R-HSA-399997	6.778383e-01	0.169	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	6.801244e-01	0.167	0
Dectin-2 family	R-HSA-5621480	6.803972e-01	0.167	0
Synthesis of PA	R-HSA-1483166	6.803972e-01	0.167	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	6.902517e-01	0.161	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	6.902517e-01	0.161	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	6.947661e-01	0.158	0
PI3K events in ERBB2 signaling	R-HSA-1963642	6.947661e-01	0.158	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.947661e-01	0.158	0
Regulation of NPAS4 gene expression	R-HSA-9768759	6.947661e-01	0.158	0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	6.947661e-01	0.158	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.975264e-01	0.156	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	6.978431e-01	0.156	0
Mitochondrial biogenesis	R-HSA-1592230	7.081077e-01	0.150	0
GABA receptor activation	R-HSA-977443	7.092713e-01	0.149	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	7.108053e-01	0.148	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	7.108053e-01	0.148	0
Synaptic adhesion-like molecules	R-HSA-8849932	7.108053e-01	0.148	0
Platelet sensitization by LDL	R-HSA-432142	7.108053e-01	0.148	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	7.108053e-01	0.148	0
Apoptotic factor-mediated response	R-HSA-111471	7.108053e-01	0.148	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	7.199470e-01	0.143	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	7.199470e-01	0.143	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	7.199470e-01	0.143	0
Diseases of Immune System	R-HSA-5260271	7.199470e-01	0.143	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.199470e-01	0.143	0
PI-3K cascade:FGFR3	R-HSA-5654710	7.260027e-01	0.139	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	7.260027e-01	0.139	0
E2F mediated regulation of DNA replication	R-HSA-113510	7.260027e-01	0.139	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	7.260027e-01	0.139	0
Protein-protein interactions at synapses	R-HSA-6794362	7.376052e-01	0.132	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	7.404023e-01	0.131	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	7.404023e-01	0.131	0
PI-3K cascade:FGFR4	R-HSA-5654720	7.404023e-01	0.131	0
VxPx cargo-targeting to cilium	R-HSA-5620916	7.404023e-01	0.131	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.404023e-01	0.131	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	7.404023e-01	0.131	0
Pregnenolone biosynthesis	R-HSA-196108	7.404023e-01	0.131	0
Protein hydroxylation	R-HSA-9629569	7.404023e-01	0.131	0
Signaling by NODAL	R-HSA-1181150	7.404023e-01	0.131	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.409505e-01	0.130	0
HIV Transcription Initiation	R-HSA-167161	7.409505e-01	0.130	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.409505e-01	0.130	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	7.468681e-01	0.127	0
Cytosolic tRNA aminoacylation	R-HSA-379716	7.509378e-01	0.124	0
XBP1(S) activates chaperone genes	R-HSA-381038	7.523596e-01	0.124	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.540460e-01	0.123	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.540460e-01	0.123	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.540460e-01	0.123	0
Lagging Strand Synthesis	R-HSA-69186	7.540460e-01	0.123	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	7.540460e-01	0.123	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	7.540460e-01	0.123	0
Vitamin C (ascorbate) metabolism	R-HSA-196836	7.540460e-01	0.123	0
RNA Polymerase II Promoter Escape	R-HSA-73776	7.605918e-01	0.119	0
TBC/RABGAPs	R-HSA-8854214	7.605918e-01	0.119	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.669734e-01	0.115	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	7.669734e-01	0.115	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	7.669734e-01	0.115	0
Serine metabolism	R-HSA-977347	7.669734e-01	0.115	0
Attachment and Entry	R-HSA-9694614	7.669734e-01	0.115	0
Ribavirin ADME	R-HSA-9755088	7.669734e-01	0.115	0
Amine ligand-binding receptors	R-HSA-375280	7.699199e-01	0.114	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.789297e-01	0.109	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.789297e-01	0.109	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.792220e-01	0.108	0
PI-3K cascade:FGFR1	R-HSA-5654689	7.792220e-01	0.108	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.792220e-01	0.108	0
LDL clearance	R-HSA-8964038	7.792220e-01	0.108	0
Neurotoxicity of clostridium toxins	R-HSA-168799	7.792220e-01	0.108	0
Extracellular matrix organization	R-HSA-1474244	7.828123e-01	0.106	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.876289e-01	0.104	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.876289e-01	0.104	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	7.876289e-01	0.104	0
Diseases of DNA repair	R-HSA-9675135	7.876289e-01	0.104	0
Termination of O-glycan biosynthesis	R-HSA-977068	7.908276e-01	0.102	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.908276e-01	0.102	0
Growth hormone receptor signaling	R-HSA-982772	7.908276e-01	0.102	0
Formation of the ureteric bud	R-HSA-9830674	7.908276e-01	0.102	0
Syndecan interactions	R-HSA-3000170	7.908276e-01	0.102	0
COPII-mediated vesicle transport	R-HSA-204005	7.910536e-01	0.102	0
MITF-M-dependent gene expression	R-HSA-9856651	7.996777e-01	0.097	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.018237e-01	0.096	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.018237e-01	0.096	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	8.018237e-01	0.096	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	8.018237e-01	0.096	0
Mitochondrial RNA degradation	R-HSA-9836573	8.018237e-01	0.096	0
Complex III assembly	R-HSA-9865881	8.018237e-01	0.096	0
Adipogenesis	R-HSA-9843745	8.029404e-01	0.095	0
NGF-stimulated transcription	R-HSA-9031628	8.041263e-01	0.095	0
Mitochondrial protein degradation	R-HSA-9837999	8.109271e-01	0.091	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.122424e-01	0.090	0
PI-3K cascade:FGFR2	R-HSA-5654695	8.122424e-01	0.090	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.122424e-01	0.090	0
Hyaluronan degradation	R-HSA-2160916	8.122424e-01	0.090	0
Interleukin-7 signaling	R-HSA-1266695	8.122424e-01	0.090	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.122424e-01	0.090	0
Azathioprine ADME	R-HSA-9748787	8.194746e-01	0.086	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.221140e-01	0.085	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.221140e-01	0.085	0
TRP channels	R-HSA-3295583	8.221140e-01	0.085	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.221140e-01	0.085	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	8.221140e-01	0.085	0
Role of phospholipids in phagocytosis	R-HSA-2029485	8.238268e-01	0.084	0
The phototransduction cascade	R-HSA-2514856	8.267373e-01	0.083	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.277459e-01	0.082	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.314671e-01	0.080	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	8.314671e-01	0.080	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.314671e-01	0.080	0
Signaling by FGFR3 in disease	R-HSA-5655332	8.314671e-01	0.080	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	8.361443e-01	0.078	0
Telomere Extension By Telomerase	R-HSA-171319	8.403289e-01	0.076	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.403289e-01	0.076	0
Pyroptosis	R-HSA-5620971	8.403289e-01	0.076	0
Amino acids regulate mTORC1	R-HSA-9639288	8.404783e-01	0.075	0
Nuclear Receptor transcription pathway	R-HSA-383280	8.418501e-01	0.075	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.487254e-01	0.071	0
DARPP-32 events	R-HSA-180024	8.487254e-01	0.071	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	8.487254e-01	0.071	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.566807e-01	0.067	0
PI Metabolism	R-HSA-1483255	8.576633e-01	0.067	0
IRS-mediated signalling	R-HSA-112399	8.650349e-01	0.063	0
Cytoprotection by HMOX1	R-HSA-9707564	8.678633e-01	0.062	0
Signaling by WNT in cancer	R-HSA-4791275	8.713596e-01	0.060	0
DNA strand elongation	R-HSA-69190	8.713596e-01	0.060	0
Extension of Telomeres	R-HSA-180786	8.759679e-01	0.058	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	8.781259e-01	0.056	0
tRNA Aminoacylation	R-HSA-379724	8.811228e-01	0.055	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.845367e-01	0.053	0
Acyl chain remodelling of PC	R-HSA-1482788	8.845367e-01	0.053	0
IRS-related events triggered by IGF1R	R-HSA-2428928	8.860791e-01	0.053	0
eNOS activation	R-HSA-203615	8.906106e-01	0.050	0
Hyaluronan metabolism	R-HSA-2142845	8.906106e-01	0.050	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.906106e-01	0.050	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.906106e-01	0.050	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.908433e-01	0.050	0
Leishmania parasite growth and survival	R-HSA-9664433	8.918154e-01	0.050	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	8.918154e-01	0.050	0
Bacterial Infection Pathways	R-HSA-9824439	8.920632e-01	0.050	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	8.963653e-01	0.048	0
Acyl chain remodelling of PE	R-HSA-1482839	8.963653e-01	0.048	0
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	8.963653e-01	0.048	0
G alpha (q) signalling events	R-HSA-416476	8.978325e-01	0.047	0
IGF1R signaling cascade	R-HSA-2428924	8.998213e-01	0.046	0
Insulin receptor signalling cascade	R-HSA-74751	8.998213e-01	0.046	0
Ion transport by P-type ATPases	R-HSA-936837	8.998213e-01	0.046	0
FCERI mediated MAPK activation	R-HSA-2871796	9.010828e-01	0.045	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.018177e-01	0.045	0
RUNX2 regulates bone development	R-HSA-8941326	9.018177e-01	0.045	0
Triglyceride catabolism	R-HSA-163560	9.018177e-01	0.045	0
PPARA activates gene expression	R-HSA-1989781	9.038987e-01	0.044	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.040477e-01	0.044	0
NCAM1 interactions	R-HSA-419037	9.069835e-01	0.042	0
Metabolism of folate and pterines	R-HSA-196757	9.069835e-01	0.042	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.093894e-01	0.041	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.118778e-01	0.040	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.118778e-01	0.040	0
Metabolism of steroid hormones	R-HSA-196071	9.120052e-01	0.040	0
Asparagine N-linked glycosylation	R-HSA-446203	9.121159e-01	0.040	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.165148e-01	0.038	0
Interleukin-2 family signaling	R-HSA-451927	9.209081e-01	0.036	0
Tryptophan catabolism	R-HSA-71240	9.209081e-01	0.036	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.209081e-01	0.036	0
Transcriptional Regulation by VENTX	R-HSA-8853884	9.250705e-01	0.034	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.250705e-01	0.034	0
Potassium Channels	R-HSA-1296071	9.274741e-01	0.033	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.290141e-01	0.032	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.290141e-01	0.032	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	9.292731e-01	0.032	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.292731e-01	0.032	0
Defensins	R-HSA-1461973	9.362901e-01	0.029	0
Formation of the cornified envelope	R-HSA-6809371	9.391903e-01	0.027	0
Methylation	R-HSA-156581	9.396438e-01	0.027	0
Surfactant metabolism	R-HSA-5683826	9.396438e-01	0.027	0
G alpha (s) signalling events	R-HSA-418555	9.425546e-01	0.026	0
Metabolism of amino acids and derivatives	R-HSA-71291	9.451666e-01	0.024	0
Interleukin-10 signaling	R-HSA-6783783	9.457721e-01	0.024	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.481383e-01	0.023	0
Synthesis of PC	R-HSA-1483191	9.486833e-01	0.023	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.513853e-01	0.022	0
Metal ion SLC transporters	R-HSA-425410	9.513853e-01	0.022	0
G alpha (i) signalling events	R-HSA-418594	9.516480e-01	0.022	0
Phospholipid metabolism	R-HSA-1483257	9.519838e-01	0.021	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.525786e-01	0.021	0
Platelet homeostasis	R-HSA-418346	9.528734e-01	0.021	0
Chemokine receptors bind chemokines	R-HSA-380108	9.539451e-01	0.020	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.543809e-01	0.020	0
PI3K Cascade	R-HSA-109704	9.563703e-01	0.019	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.608447e-01	0.017	0
Nucleotide biosynthesis	R-HSA-8956320	9.629070e-01	0.016	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.638221e-01	0.016	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.667498e-01	0.015	0
Neurotransmitter release cycle	R-HSA-112310	9.698437e-01	0.013	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.698437e-01	0.013	0
Triglyceride metabolism	R-HSA-8979227	9.731915e-01	0.012	0
Regulation of beta-cell development	R-HSA-186712	9.731915e-01	0.012	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.731915e-01	0.012	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.731915e-01	0.012	0
Signaling by Insulin receptor	R-HSA-74752	9.737136e-01	0.012	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.746040e-01	0.011	0
FCGR activation	R-HSA-2029481	9.748935e-01	0.011	0
Collagen degradation	R-HSA-1442490	9.759423e-01	0.011	0
Complex I biogenesis	R-HSA-6799198	9.784111e-01	0.009	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.784111e-01	0.009	0
CD22 mediated BCR regulation	R-HSA-5690714	9.795489e-01	0.009	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.816009e-01	0.008	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.816480e-01	0.008	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.818311e-01	0.008	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.826154e-01	0.008	0
Kidney development	R-HSA-9830369	9.826154e-01	0.008	0
O-linked glycosylation of mucins	R-HSA-913709	9.835318e-01	0.007	0
Cardiac conduction	R-HSA-5576891	9.857097e-01	0.006	0
Peptide ligand-binding receptors	R-HSA-375276	9.858383e-01	0.006	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.860017e-01	0.006	0
Metabolism of cofactors	R-HSA-8978934	9.860017e-01	0.006	0
ECM proteoglycans	R-HSA-3000178	9.860017e-01	0.006	0
Retinoid metabolism and transport	R-HSA-975634	9.860017e-01	0.006	0
Degradation of the extracellular matrix	R-HSA-1474228	9.863027e-01	0.006	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.863766e-01	0.006	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.887290e-01	0.005	0
Bile acid and bile salt metabolism	R-HSA-194068	9.896378e-01	0.005	0
Antimicrobial peptides	R-HSA-6803157	9.901152e-01	0.004	0
Integrin cell surface interactions	R-HSA-216083	9.904200e-01	0.004	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.909254e-01	0.004	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.918576e-01	0.004	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.925597e-01	0.003	0
Peptide hormone metabolism	R-HSA-2980736	9.932346e-01	0.003	0
Visual phototransduction	R-HSA-2187338	9.934059e-01	0.003	0
Sulfur amino acid metabolism	R-HSA-1614635	9.941185e-01	0.003	0
Collagen formation	R-HSA-1474290	9.963902e-01	0.002	0
Mitochondrial translation elongation	R-HSA-5389840	9.969324e-01	0.001	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.969324e-01	0.001	0
Mitochondrial translation initiation	R-HSA-5368286	9.972479e-01	0.001	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.979021e-01	0.001	0
Keratinization	R-HSA-6805567	9.981073e-01	0.001	0
Respiratory electron transport	R-HSA-611105	9.984092e-01	0.001	0
Mitochondrial translation termination	R-HSA-5419276	9.985654e-01	0.001	0
GPCR downstream signalling	R-HSA-388396	9.990022e-01	0.000	0
Transport of small molecules	R-HSA-382551	9.996548e-01	0.000	0
O-linked glycosylation	R-HSA-5173105	9.997615e-01	0.000	0
Mitochondrial translation	R-HSA-5368287	9.997741e-01	0.000	0
Metabolism of steroids	R-HSA-8957322	9.998061e-01	0.000	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.998887e-01	0.000	0
Metabolism of nucleotides	R-HSA-15869	9.998970e-01	0.000	0
Signaling by GPCR	R-HSA-372790	9.999002e-01	0.000	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999617e-01	0.000	0
Diseases of metabolism	R-HSA-5668914	9.999642e-01	0.000	0
Drug ADME	R-HSA-9748784	9.999658e-01	0.000	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999805e-01	0.000	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999814e-01	0.000	0
Diseases of glycosylation	R-HSA-3781865	9.999835e-01	0.000	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999899e-01	0.000	0
Sphingolipid metabolism	R-HSA-428157	9.999935e-01	0.000	0
Phase I - Functionalization of compounds	R-HSA-211945	9.999984e-01	0.000	0
Metabolism of vitamins and cofactors	R-HSA-196854	9.999985e-01	0.000	0
Phase II - Conjugation of compounds	R-HSA-156580	9.999992e-01	0.000	0
GPCR ligand binding	R-HSA-500792	9.999998e-01	0.000	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000	0
Biological oxidations	R-HSA-211859	1.000000e+00	0.000	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0